Kornimate/medical-research-clean huggingface dataset:
utmb research on severe asthma (urosa) study

Conditions: Asthma

Summary: to identify and understand biologic aspects of severe asthma compared to subjects with mild to moderate asthma and subjects without asthma (normal or healthy volunteers).

it has been shown that severe asthma differs from milder asthma in its pathophysiology; in particular we are interested in examining why patients with severe asthma have disease that is resistant to corticosteroids. while we will be studying patients with severe asthma, we also need to study subjects to act as controls. to this end we will recruit subjects into the following groups: normal volunteers; mild asthmatics not taking inhaled corticosteroids; mild to moderate asthmatics requiring and using inhaled corticosteroids and severe asthmatics. subjects between the ages of 18 and 65 will be enrolled in this study. we aim to recruit enough subjects such that 120 male and female participants (30 in each of the above groups) will complete the bronchoscopy.

Eligibility criteria:
inclusion criteria: * all participants must be in good general health (with exception to asthma). • normal controls / healthy volunteers (nc) subjects with no past history of asthma or other lung disease. to determine this, subjects must have an fev1 equal to or greater than 80% of predicted value and have a normal fev1/fvc ratio. asthma subjects eligible asthmatic participants must have a physician diagnosis of asthma for at least 1 year. participants must either have historical evidence of reversibility of fev1 of at least 12%, or demonstrate such a change during the study visits, or must have historical evidence of a pc20 for methacholine \< 8mg/ml. * mild asthma with no corticosteroids (manc) will be defined as control of asthma with short acting β2-agonists or leukotrine antagonist or both, but not requiring inhaled corticosteroids. * mild to moderate asthma (mma) will be defined as control of asthma with an inhaled corticosteroid (less than or equal to 250 mcg daily inhaled fluticasone equivalent) in addition to the medications listed in the manc group or long acting β2-agonists. * severe asthma (sa) will be defined according to the ats criteria for refractory asthma (10) exclusion criteria: * exclusion criteria apply for all subjects: * current smoker, or former smoker with \>10 pack years history or having quit within the past year * asthma exacerbation, requiring a new or increased dose of oral corticosteroids, within the past 30 days * pregnant or lactating female * significant/uncontrolled medical condition (uncontrolled diabetes, coronary artery disease, uncontrolled hypertension) * diagnosis of emphysema or other significant pulmonary disease * if, in the opinion of the pi (wjc) the subject has co-morbid conditions that make them unsafe to undergo bronchoscopy, subjects will be given the choice to withdraw from the study or allowed to complete visits 1-3 only.
lung functions in menopausal obese women after covid 19 recovery

Conditions: Lung Function Decreased; Obesity; Menopause; Covid19

Summary: the covid-19 pandemic has presented considerable challenges to global health services and dictates almost every aspect of medical practice and policy. the menopausal transition may have significant consequences for respiratory health as covid 19 symptoms subsides, lung function testing should be done to assess the consequences of this virus on lung health especially in menopausal woman.

the study group will consist of (40) obese menopausal women whom were recently recovered from mild-moderate covid 19 for one month. the control group will consist of (40) obese menopausal women; whom will not affected by covid 19. using incentive spirometer, we will measure forced vital capacity fvc, forced expiratory volume fev, tiffano index ti and peak expiratory force pef in both groups.

Eligibility criteria:
inclusion criteria: * participants recovered from mild to moderated signs and symptoms of covid- 19 after one month. * ability to perform pulmonary function tests correctly. * covid-19 was diagnosed by positive polymerase chain reaction (pcr) testing on nasopharyngeal swab, oxygen saturation was ranged between 92-96% during illness period. * ct chest shows ground glass opacity. * their d-dimer was less than 0.5 μg/ml. * two successive negative pcr were before included in study. * participants were in home isolation during illness period. exclusion criteria: * chronic respiratory disease. * chronic heart disease. * diabetes mellitus. * smoking. * centralized isolation. * severe covid-19.

Keywords: lung funnctions menopause obesity covid19
compassion focused therapy and breathing pattern retraining after cancer recurrence

Conditions: Psychological Distress; Cancer Recurrence

Summary: the purpose of this study is to investigate how effective a particular psychological intervention is at reducing psychological distress for people who were diagnosed with cancer 'recurrence' since the beginning of the covid pandemic.

this study plans to study how effective a particular psychological intervention is at reducing psychological distress for people who were diagnosed with cancer 'recurrence' since the beginning of the pandemic, having previously been diagnosed with cancer. we know that a cancer diagnosis can often result in significant psychological distress. after or during treatment for cancer, individuals often experience a 'fear of recurrence', which should it occur, often results in a state of mental anguish that is described as being more punishing than the initial diagnosis itself. being diagnosed with a cancer recurrence diagnosis can trigger marked negative psychological symptoms, including distress, uncertainty, traumatic distress and adjustment problems, with psychological recovery from this diagnosis often being slower than that of the initial cancer diagnosis. the covid-19 pandemic has affected these patients further, in terms of restricted access to healthcare, reduced social supports, and greater levels of treatment uncertainty. our research team has designed a psychological intervention that is specifically aimed to help some of these issues. it's a 6-week online group intervention using a 'compassion focused therapy' approach, coupled with specialised breathing techniques to reduce bodily distress. it is being done online due to ongoing concerns around covid but also to eliminate geographical and/or commuting barriers. it is our expectation that those receiving the psychological intervention will experience noticeable reductions in measures of psychological distress compared to those who are receiving regular treatment. it is our hope that the outcomes of this study will inform how best to help patients facing into cancer recurrence at a national level.

Eligibility criteria:
inclusion criteria: * adults aged 18 or older * pre-existing cancer diagnosis * diagnosis of cancer recurrence during covid-19 (march 2020 onwards) * living in ireland * english speaking / fluency * access to web / tech support exclusion criteria: * a score \<4 on the distress thermometer * patient non-consent * the presence of a severe mental illness (such as schizophrenia, personality disorder or active illness) * known or suspected drug or alcohol abuse problems within past 3 months * inability to follow the study procedures e.g. dementia or non-fluency of english * life expectancy \<3 months
effects of vitamin a supplementation on intestinal parasitic reinfections

Conditions: Intestinal Parasitic Infections; Malnutrition; Anemia

Summary: intestinal parasitic infections, malnutrition and iron deficiency anaemia (ida) are still considered as public health problems in rural malaysia especially among orang asli children. despite intermittent control programmes, the prevalence of these problems is still high suggesting the need of other control and interventions measures. this randomized double-blind, placebo-controlled trial was carried out among orang asli schoolchildren from sekolah kebangsaan betau in pos betau, pahang (200 km northeast kuala lumpur) to investigate the effects of vitamin a supplementation on intestinal parasitic reinfections, growth, iron status and educational achievement. hypotheses 1. vitamin a supplementation has a negative effect on intestinal parasitic reinfections and the worm burden of infections among orang asli schoolchildren in pos betau, kuala lipis, pahang. 2. vitamin a supplementation has a positive effect on growth (weight and height) among orang asli schoolchildren. 3. vitamin a supplementation is effective in improving serum iron status among orang asli schoolchildren. 4. vitamin a supplementation has a positive effect on cognitive function and educational achievement among orang asli schoolchildren.

children from sekolah kebangsaan betau in pos betau, kuala lipis, pahang served as the target population for this study. the selection criteria for study subjects were the following: * age 7-12 years (according to birth date in birth certificate). * non-menstruating females (age \<13) * no history or evidence of underlying haematological-related diseases such as thalassaemia and ovalocytosis. * no evidence of concomitant severe and/or chronic illness such as acute respiratory tract infections, mental retardation and neurological deficits. * consent of parent to participate in the study.

Eligibility criteria:
inclusion criteria: * age 7-12 years (according to birth date in birth certificate). * no evidence of concomitant severe and/or chronic illness such as acute respiratory tract infections, mental retardation and neurological deficits. * consent of parent to participate in the study. exclusion criteria: * history or evidence of underlying haematological-related diseases such as thalassaemia and ovalocytosis. * menstruating females (age \>13)

Keywords: intestinal parasitic infections malnutrition anemia
project get fit with ms: guidelines for exercise training and fitness outcomes in ms

Conditions: Multiple Sclerosis

Summary: the purpose of this study is to test different types of exercise training for people with multiple sclerosis (ms). the exercise program is based on physical activity guidelines that have been developed specifically for people with ms. the investigators believe these guidelines will be effective for improving physical fitness and function in persons with mild-to-moderate ms.

most adults with multiple sclerosis (ms) are physically inactive. one approach to address physical inactivity in this population has involved the provision of physical activity guidelines. such physical activity guidelines are an important tool for exercise prescription, promotion, and monitoring, and recommend that people with ms "participate in at least 30 minutes of moderate intensity aerobic activity 2 times per week and strength training exercises for major muscle groups 2 times per week." the guidelines were developed from a systematic literature review and have yet to be tested for efficacy in improving fitness or other outcomes. this study will test that efficacy of aerobic and resistance training alone and in combination (based on the ms physical activity guidelines) for improving physical fitness and other outcomes (e.g., walking, thinking, ms symptoms) in persons with ms who have mild-to-moderate disability. such an examination will be important to confirm the efficacy of the exercise prescription for people with ms and health-care providers. the investigators will further perform an exploratory analysis of blood biomarkers and eye imaging parameters to examine some of the mechanisms of exercise training effects in persons with ms.

Eligibility criteria:
inclusion criteria: * a definite diagnosis of ms * self-reported expanded disability status scale (edss) score \< 6.0 or patient determined disability steps (pdds) scale score ≤ 3.0 * relapse free in past 30 days * willing and able to visit the university of illinois at urbana-champaign for on seven occasions (two testing visits; five training visits) and participate in a 6-month home-based exercise program * non-exerciser * asymptomatic and physician approval for undertaking exercise testing and training exclusion criteria: * currently pregnant

Keywords: multiple sclerosis exercise home-based training fitness
cross cultural validation of the italian version of the bt-dux

Conditions: Quality of Life; Bone Neoplasm

Summary: the purpose of the presented study is to translate the english bt-dux (bt-dux-eng) questionnaire into the italian language and then examine the validity of the italian version of the bt-dux (bt-dux-it).

validation of the italian bt-dux: cross sectional study among patients of the istituto ortopedico rizzoli, bologna, italy, will carry out. all patients who underwent a surgical intervention due to a malignant bone tumour in the leg will be identified through hospital records and a survey consisting of different qol questionnaires will be executed: bt-dux, eortc qlq c-30, the toronto extremity salvage score (tess).

Eligibility criteria:
inclusion criteria: * patients are eligible if they're aged between 15 and 25 years at the time of the selection, if the time since surgery is ranged between 12 and 60 months, if the malignant bone tumour (osteosarcoma or ewing's sarcoma) was located around the hip or the knee and the surgical intervention consisted of limb sparing or ablative surgery. exclusion criteria: * patients will be excluded if other medical conditions limit their physical activities.
open-label extension study of enlicitide decanoate (mk-0616/enlicitide oral pcsk9 inhibitor) in adults with hypercholesterolemia (mk-0616-019) coralreef extension

Conditions: Hypercholesterolemia

Summary: this is an extension study to evaluate the longer-term safety and efficacy of enlicitide decanoate in adults with hypercholesterolemia who completed either study mk-0616-013 (nct05952856), study mk-0616-017 (nct05952869), or study mk-0616-018 (nct06450366).


Eligibility criteria:
inclusion criteria: * has completed an enlicitide decanoate (also known as enlictide and mk-0616) parent study \[mk-0616-013 (nct05952856), mk-0616-017 (nct05952869), and mk-0616-018 (nct06450366)\] per protocol (including the final assessments/procedures of their parent study) * had an overall study intervention compliance ≥80% while participating in their parent study exclusion criteria: * has discontinued study intervention in their parent study * has an ongoing serious adverse event considered related to study intervention by the investigator in the parent study * is planning to begin treatment with a nonstudy protein convertase subtilisin/kexin type 9 inhibitor (pcsk9i) while enrolled in the study * is currently participating in an interventional clinical study other than an enlicitide decanoate parent study
therapy for depressed elders with thought problems

Conditions: Depression; Cognition Disorders

Summary: this study will compare the effectiveness of problem solving therapy and brief supportive therapy in treating elderly patients with major depression and thought problems.

patients who suffer from a combination of major depression and executive dysfunction symptoms often respond poorly to treatment with antidepressants. it is important, therefore, to find effective alternative therapies to treat these symptoms. patients are randomly assigned to receive 12 sessions (1 session/week for 12 weeks) of either pst or bst. following treatment, patients are followed for 6 months to determine functional and clinical outcomes. depression scales, disability scales, and scales that measure problem solving skills are used to assess patients.

Eligibility criteria:
inclusion criteria: * nonpsychotic, unipolar major depression * cognitive impairment * english speaking exclusion criteria: * high suicide risk * dementia * acute or severe medical illness * current psychotherapy

Keywords: geriatrics
discovering trends in chronic fatigue syndrome patients' clinical study experiences

Conditions: Chronic Fatigue Syndrome

Summary: the study seeks to delve into the firsthand experiences of patients diagnosed with chronic fatigue syndrome who partake in a separate clinical trial featuring a specific medical intervention. the primary emphasis will be on meticulously tracking the rates of trial completion and withdrawal among these individuals. the data collected from this study will help improve future outcomes for all chronic fatigue syndrome patients as well as those in under-represented demographic groups.


Eligibility criteria:
inclusion criteria: * signed written informed consent * aged ≥ 18 years old * no prior treatment for chronic fatigue syndrome exclusion criteria: * participant is actively receiving study therapy in another * inability to provide written informed consent * women of childbearing potential without a negative pregnancy test; or women who are lactating.

Keywords: chronic fatigue syndrome
improving evidence-based care for cancer patients

Conditions: Head and Neck Cancer; Prostate Cancer; Breast Cancer; Lung Cancer; Gynecologic Cancer; Gastrointestinal Cancer

Summary: the purpose of this study is to improve cancer care and the delivery of cancer care. researchers are interested in studying patient reported information and examining how different factors may impact cancer care.


Eligibility criteria:
inclusion criteria: * diagnosed with head/neck, lung, breast, prostate, gastrointestinal or gynecologic cancer * 21 years of age or older at time of study registration * must have been referred to musc radiation oncology for treatment with curative radiation therapy * must report current smoking defined as self-reporting smoking within the past 30 days using a structured intake questionnaire. exclusion criteria: * patients with primary central nervous system malignancies will be excluded. * patients that have other cancer disease types will be excluded due to either significant differences in standard radiation therapy approaches or rarity of disease required radiation. * patients who are currently participating in the medical university of south carolina hollings cancer center smoking cessation program * patients who are unable to provide informed consent
high dose chemotherapy and allogeneic hematopoietic cell transplant for non-hodgkin's lymphoma

Conditions: Lymphoma, Non-Hodgkin; Blood and Marrow Transplant (BMT); Lymphomas: Non-Hodgkin

Summary: to evaluate the role of allogeneic hematopoietic cell transplantation in the treatment of nhl.

to determine safety and toxicity of a regimen of high dose chemotherapy with allogeneic peripheral blood progenitor cell transplantation; determine the efficacy of the procedure by following clinical outcomes and quality of life measures; and evaluate graft versus host disease incidence and severity with regimen.

Eligibility criteria:
inclusion criteria:morphologically confirmed relapsed non-hodgkin's lymphoma age: \>18 and \<61 years of age signed informed consent exclusion criteria:hepatic dysfunction defined by serum transaminases \>2.5x normal values serum creatinine of \> 2 mg/dl or creatinine clearance \< 60 ml/min diseases other than non-hodgkin's lymphoma prior bone marrow transplant procedure severe psychological or medical illness
tcd detection of ophthalmic artery blood flow velocity prediction feasibility study of intracranial pressure

Conditions: Traumatic Brain Injury; Cerebral Hemorrhage; Increased Intracranial Pressure

Summary: increased intracranial pressure is a cause of disease progression in patients with brain disease, a common cause of poor prognosis. intracranial pressure monitoring is the observation of the disease, treatment, evaluation and important way to improve the prognosis. non-invasive intracranial pressure monitoring can be used to stroke, intracranial hemorrhage, brain trauma, encephalitis and other patients. ophthalmic artery originated from the internal carotid artery, the optic canal into the orbit, the entire process can be divided into intracranial optic tube segment and orbital segment. investigators' preliminary experiments show that when intracranial pressure, intracranial ophthalmic artery segment velocity increases with increasing velocity difference orbital segment. accordingly, the investigators speculate, may be judged by the level of intracranial pressure intracranial and orbital velocity difference between the ophthalmic artery segment, and accordingly calculate the specific values of intracranial pressure. the investigators will collect brain trauma surgery, performed invasive intracranial pressure monitoring cases, the use of transcranial doppler ultrasound velocity and different segments of the ophthalmic artery pulsatility index, the invasive intracranial pressure and comparing the measured values to calculate the the critical value of the ophthalmic artery segment intraorbital and intracranial velocity difference when intracranial pressure, thus fitting based on projections of mathematical formulas intracranial pressure. this study will provide a non-invasive intracranial pressure monitor new approach.

2014/08/28

Eligibility criteria:
inclusion criteria: 1. age 18-75 years of age (including 18 and 75 years), gender, ethnic limitation; 2. have been carried out invasive intracranial pressure monitoring; 3. the patient or his agent informed consent. - exclusion criteria: 1. the patient does not fit, measured by tcd can not be completed; 2. tcd failed to detect the satisfaction of the ophthalmic artery flow signals were; 3. patients with ocular trauma or a history of intraocular pressure -

Keywords: tcd traumatic brain injury increased intracranial pressure
researching axium coiling experience and recanalization (racer)

Conditions: Aneurysms; Vascular Diseases; Cerebrovascular Disorders; Intracranial Arterial Diseases

Summary: the data collected in this study will be used to support international regulatory submissions. the study objective is to evaluate the continued safety and efficacy of the axium progressive coil system. this device has been used clinically at approximately 150 institutions under fda 510(k) clearance since april 24, 2007. the device received ce authorization on june 30, 2007. through december 2007, more than 1000 patients have been treated with the axium coils.


Eligibility criteria:
inclusion criteria: * patient or patient's legally authorized representative has signed and dated an informed consent form * must be at least 18 years of age * aneurysm location, angio-architecture, morphology, or medical condition, is considered by the neurosurgical / interventional team to be at very high risk for management by traditional operative techniques, or aneurysm is considered to be inoperable * patient is willing to conduct follow-up visits exclusion criteria: * aneurysm was previously treated * patient has a cerebral aneurysm with a location, angioarchitecture or morphology that presents an unacceptable risk of morbidity due to the study procedures * patient is participating in another clinical research study * patient has a medical, social or psychological condition, which precludes the patient from receiving study required treatment, evaluation, procedures and follow-up * female patient is pregnant or breast-feeding

Keywords: ev3 neurovascular aneurysms cerebrovascular endovascular neurovascular therapies racer axium the axium progressive coil system ev3 mti micro therapeutics fx detachable coil system k060747 brain diseases
phase i study on monoclonal antibody tb-403 directed against plgf in patients with solid tumours

Conditions: Solid Tumors

Summary: tb-403 is a monoclonal antibody directed against placental growth factor (plgf). the antibody binds to plgf and inhibits the binding to it's receptor, vegf-1. by preventing this binding, growth of tumor vessels are inhibited and tumor growth prevented. in this study we are investigating the tolerability and safety of tb-403 in patients with solid tumors who receives multiple intravenous doses of tb-403.


Eligibility criteria:
inclusion criteria: * confirmed malignity * measurable disease * performance status 1 or less (ecog) exclusion criteria: * acute illness or infection * concurrent second malignancy

Keywords: placental growth factor monoclonal antibody phase i solid tumors patients with solid tumors