Kornimate/medical-research-clean huggingface dataset:
digital based home care service for ostomy patients

Conditions: Colorectal Neoplasms; Stoma Colostomy; Stoma Ileostomy

Summary: this study aims to enhance the physical, psychological, and social aspects of stoma care by providing a self-management service via a smartphone application, and to evaluate the impact of this digital-based application on patients' quality of life.

this study will include patients who have undergone colorectal cancer surgery and received either a colostomy or ileostomy, provided they are comfortable using digital devices like smartphones. patients will be randomly assigned to either the intervention group, receiving stoma care through a smartphone application, or the conventional group, receiving standard outpatient-based care. the intervention group will use a mobile application where patients input their stoma condition, allowing healthcare professionals to monitor and manage their care. the app provides patients with information on diet, physical activity, stoma care, emotional support, and daily living needs. both groups will be assessed for outcomes at the time of enrollment, and at 1 and 6 months. outcome measures include stoma-related complications such as peristomal dermatitis, dehydration, acute renal failure, readmission due to stoma-related issues, and quality of life and emotional state assessments using eq-5d-5l and stoma quality of life questionnaires.

Eligibility criteria:
inclusion criteria: * patients aged 19 years or older * patients who have a colostomy or ileostomy after surgery for colon cancer * patients who do not have difficulty using a smartphone exclusion criteria: * patients younger than 19 years * patients aged 80 years or older * patients who do not know how to use a smartphone * patients with cognitive impairments * patients with pre-existing psychiatric disorders * patients who have undergone emergency surgery * patients who already have stoma-related complications

Keywords: stoma colorectal neoplasms quality of life
evaluation of safety and tolerability of creon micro in children younger than four years with pancreatic exocrine insufficiency

Conditions: Pancreatic Exocrine Insufficiency

Summary: the purpose of this study is to evaluate the safety and tolerability of creon micro in children younger than four years with pancreatic exocrine insufficiency.

a prospective open-label, multi-center study evaluating safety and tolerability of creon micro in pediatric subjects from at least one month to less than four years of age with pancreatic exocrine insufficiency (pei) due to cystic fibrosis (cf). referring to the european medicines agency (emea) pediatric age criteria for the purpose of the study, subjects are categorized as infants and toddlers (\< 2 years) and children, (2 years to \< 4 years). in total, 40 subjects will be enrolled (20 subjects in each age subgroup). subjects receive their prescribed pancreatic enzyme supplementation at the individual dose until start of treatment with creon micro, if the subjects were on pancreatic enzyme supplementation before start of the study. subjects will be treated with creon micro during the study. the treatment duration is 3 months.

Eligibility criteria:
inclusion criteria: * children younger than four years with confirmed cystic fibrosis diagnosis and a body weight of at least 2 kilograms exclusion criteria: * ileus or acute abdomen * history of fibrosing colonopathy * history of distal ileal obstruction without surgery * solid organ transplant or surgery affecting the large bowel, other than appendectomy

Keywords: cystic fibrosis
evaluation of the efficacy and safety of alv003 in symptomatic in celiac disease patients

Conditions: Celiac Disease

Summary: to determine the effects of 12 weeks administration of different dose levels of alv003 on the mucosal lining of the small intestine and symptoms in celiac disease patients.


Eligibility criteria:
inclusion criteria: * ages 18 to 80 years * physician diagnosed celiac disease * adherence to a gluten-free diet * experiencing symptoms of celiac disease over a 1-month period * willing to take study medication for 12 weeks * willing to comply with all study procedures * sign informed consent exclusion criteria: * active inflammatory bowel disease * active dermatitis herpetiformis * use of certain specific medications prior to entry * history of alcohol or illicit drug abuse in previous 6 months * pregnant or lactating * received any experimental drug within 30 days of enrollment * uncontrolled chronic disease or condition

Keywords: celiac disease gluten-free diet coeliac disease celiac sprue
london asthma diagnostics study

Conditions: Asthma

Summary: the goal of this trial is to learn if the addition of oscillometry with reversibility testing increases diagnostic accuracy in adult asthma diagnosis, when added to current standard of care tests: spirometry with reversibility testing and fractional exhaled nitric oxide (feno). the main question it aims to answer is: - does oscillometry with reversibility testing increase diagnostic accuracy in detection of asthma in adults when added to spirometry with reversibility and feno? researchers will evaluate the diagnostic accuracy of this approach with the reference standard, which is a clinically adjudicated diagnosis of asthma by two respiratory clinicians based on history and investigation results. participants will * undergo oscillometry testing alongside their routine asthma investigations within their scheduled clinic visit * optionally participate in our sub-studies on new breath and nasal swab tests for asthma * optionally participate in our qualitative substudy on patients views and attitudes to asthma testing and oscillometry


Eligibility criteria:
inclusion criteria: * patients referred by gp with either (a) possible incident asthma or (b) a diagnostic label of asthma without prior confirmatory objective diagnosis * age≥18 years * willing to allow his or her general practitioner and consultant, if appropriate, to be notified of participation in the study * able to give informed consent exclusion criteria: * age \<18 years * a chest infection or exacerbation requiring antibiotics or steroids within 4 weeks of testing * contraindications to spirometry testing * established or coded diagnosis of copd * pregnancy or lactating * other medical condition that in the opinion of the investigator would preclude compliance with the study protocoll * inability to understand english * involvement in clinical trial of an investigational medicinal product
evaluation of the effectiveness of dry needling versus foam roller

Conditions: Myofascial Pain Syndromes; Dry Needling

Summary: to compare the effects of dry needling and foam roller in myofascial trigger points. needling has been shown to decrease pain in the short term; however, its effects on muscle force production are unclear. there are differences between dry needling and foam roller after treatment?

background: it has been shown that the decrease of the range of motion in the ankle, due to the presence of latent trigger points in the gastro-sole complex, can affect performance, as well as being a predisposing factor to injury. objective: to compare the effects of dry needling and foam roller in healthy athletes with limited dorsal ankle flexion by the presence of latent trigger points. material and methods: this is a clinical trial, single-blind experimental study. the sample will have a total of 44 students, volunteers, healthy of the degree of physiotherapy of the the investigator's university (ucv). participants who meet the inclusion criteria will be randomly assigned in two groups: group 1 or dry needling (n = 22) and group 2 or foam roller (n = 22). the range of motion of ankle will be assessed through the leg motion system (check your motion®, albacete, spain). assessed thought ankle test (post-intervention and 24 hours later). the reference values to consider the decreased ankle rom will be \<11.5 cm, \<35º measured with easy angle® digital goniometer (meloq ab, sweden) and/or if it has a difference of 1.5 cm between both extremities. thus, the effect on previous activity performance will be assessed thought the counter movement jump. data analysis: once the distribution of the sample is determined, a descriptive analysis of the data will be carried out and an anova of repeated measures. will be used to compare the data found in the two groups that make up the study taking into account a 95% ci and an error less than 0.05.

Eligibility criteria:
inclusion criteria: * students of physiotherapy degree of the university * all participants who present restriction on active ankle dorsiflexion (\<35º). * they must be diagnosed through manual therapy of latent pg in the gastro-soleus complex. exclusion criteria: * subjects suffering from belonephobia * pathology of connective tissue * coagulation problems * lymphatic disorders * diabetes * surgical history in the lower limb (last 12 months) * prior treatment with dry needling (last 6 months)

Keywords: dry needling myofascial pain syndromes ankle joint
a study in adults to test the effects of low dose thimerosal on symptoms of covid-19

Conditions: SARS-CoV-2 Infection

Summary: clinical trial to compare sublingual low does thimerosal in adults that have symptoms of sars-cov-2 infection against placebo to show a difference in physical characteristics and viral levels.


Eligibility criteria:
inclusion criteria: * 40 years of age or older * provide written informed consent * have a sars-cov-19 diagnostic test with positive results exclusion criteria: * having an oxygen saturation level below 92% at baseline or currently on oxygen therapy * subjects currently hospitalized * subjects who have received a covid vaccination * subjects with a diagnosis of immunodeficiency

Keywords: treatment for covid-19
internal hernias after gastric bypass can be prevented safely with primary closure of all mesenteric defects with clips

Conditions: Internal Hernias

Summary: the purpose of this study is to determine whether closure of all mesenteric defects with clips at the time of gastric bypass, can avoid the complication of late bowel obstruction- internal hernias


Eligibility criteria:
inclusion criteria: * all patients who meet the requirements for a gastric bypass at køge hospital. exclusion criteria: * patients who do not meet the inclusion criteria * patients who converted to open surgeon

Keywords: internal hernias clips gastric bypass avoid
clinical study evaluating an acetabular cup system after total hip replacement

Conditions: Osteoarthritis; Rheumatoid Arthritis; Arthritis; Avascular Necrosis; Acute Fracture

Summary: this study is a clinical evaluation of survivorship of an acetabular cup system after total hip replacement using patient examinations and questionnaires.

the primary objective of this investigation is to evaluate survivorship at five years of the pinnacle™ acetabular cup system in primary total hip arthroplasty.

Eligibility criteria:
inclusion criteria: * primary hip replacement * sufficient bone stock to support implant * signed informed patient consent form exclusion criteria: * prior renal transplant * history of active joint sepsis * recent high dose of corticosteroids * primary or secondary carcinoma in the last 5 years * neurological disease * psychosocial disease that would limit rehabilitation * use of structural bone graft * simultaneous participation in another hip study

Keywords: total hip replacement post-traumatic arthritis
itch sensation induced by simultaneous application of pruritogens (spatial summation)

Conditions: Histamine; Cowhage

Summary: in this experiment, the investigators would like to design a new itch model based on the spatial summation of pruritic stimuli. the hypothesis behind this study (spatial summation) is that two simultaneous applications of pruritogens will result in higher itch sensation compared with a single application of pruritogen.

chronic itch affects approximately a fifth of the global population and is associated with substantial negative consequences for the affected individuals. furthermore, there is a lack of efficient treatment options for chronic itch. in order to mimic a clinical itch condition as presented in patients, the aim of the project is to investigate a new itch model based on the spatial summation of pruritic stimuli. the aim of this experiment is to assess the itch sensation induced by simultaneous application of pruritogens (spatial summation). in particular, the purpose is to evaluate if a single application of cowhage/histamine (non-histaminergic and histaminergic itch respectively) results in a lower itch sensation compared to two simultaneous applications of the pruritogens, on the same arm or in different arms.

Eligibility criteria:
inclusion criteria: * healthy men and women * 18-60 years * speak and understand english exclusion criteria: * pregnancy or lactation * drug addiction defined as any use of cannabis, opioids, or other addictive drugs * previous or current history of neurological (e.g. neuropathy), immunological (e.g. asthma, immune deficiencies, arthritis) musculoskeletal (e.g. muscular pain in the upper extremities,), cardiac disorder, or mental illnesses that may affect the results * lack of ability to cooperate * current use of medications that may affect the trial such as antihistamines, antipsychotics, and pain killers, as well as systemic or topical steroids * skin diseases (e.g. atopic dermatitis, pruritus nodularis, eczema, psoriasis) * moles, scars, or tattoos in the area to be treated or tested. * consumption of alcohol or painkillers 24 hours before the study days and between these * acute or chronic pain * participation in other trials within one week of study entry (four weeks in the case of pharmaceutical trials)
analysis of foot plantar pressure behavior of children with obstetric brachial plexus paralysis

Conditions: Brachial Plexus Palsy; Gait Disorders in Children

Summary: the aim of this study was to investigate the foot plantar pressure behavior alterations during gait for children with obstetric brachial plexus (obbp). 19 children with obbp and 10 healthy children will be included in the study. the inclusion criteria of the study were to be between the ages of 7-15, not have a history of surgery or botox in the last 6 months, and not have any other disease. foot plantar pressures of all participants will be analyzed with a pedobarography device. for arm swing analysis, a video camera will be recorded during walking and arm flexion/extension angles will be measured with kinovea software.


Eligibility criteria:
inclusion criteria: - between the ages of 7-15. no other disease exclusion criteria: - having undergone surgery or botox intervention for orthopedic problems in the last 6 months. having health problems in the unaffected extremity or adversely affecting general body health. the participant's parent has not signed the consent form.

Keywords: brachial plexus palsy gait disorders in children biomechanics gait analysis
pulmonary assessment in thoracic insufficiency syndrome patients

Conditions: Thoracic Insufficiency Syndrome

Summary: thoracic insufficiency syndrome (tis) is a complex condition that involves chest wall deformities that can affect normal breathing and lung growth. in most cases, children with tis are also born with spine disorders such as scoliosis. the inability of the thorax to support normal respiration or lung growth can cause respiratory distress and even mortality. investigators aim to validate mri imaging sequences to use as an assessment tool for pulmonary function.


Eligibility criteria:
inclusion criteria: * males or females 6 to 18 years old diagnosed with thoracic insufficiency syndrome who are undergoing surgery exclusion criteria: * patients not diagnosed with thoracic insufficiency syndrome

Keywords: hyperpolarized mri dynamic lung mri
clinical trial of ridaforolimus compared to progestin or chemotherapy for advanced endometrial carcinoma (mk-8669-007 am6)

Conditions: Endometrial Cancer

Summary: the purpose of this study is to compare progression-free survival (pfs) of patients with advanced, recurrent or metastatic endometrial cancer who have received one, but not more than two, prior lines of chemotherapy either as adjuvant therapy or treatment for advanced disease, and then when treated with ridaforolimus or the investigators' choice of progestin or chemotherapy.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * endometrial cancer * patients must have been treated with at least one line of chemotherapy, but not more than two lines of chemotherapy, and experienced progressive disease * at least one measurable lesion * ecog performance status less than or equal to 1 * minimum life expectancy of 3 months * adequate renal and hepatic function * adequate bone marrow function * serum cholesterol \<350 mg/dl and triglycerides \< 400 mg/dl * able to understand and give written informed consent * females of childbearing potential must have a negative pregnancy test and use approved contraception from screening to 30 days after the last study drug is given exclusion criteria: * two lines of chemotherapy for recurrent or metastatic disease * chemotherapy for recurrent or metastatic disease administered within six months of adjuvant therapy * more than two lines of chemotherapy of any type * prior therapy with hormonal agents * women who are pregnant or lactating * presence of brain or other central nervous system metastases * prior therapy with rapamycin, rapamycin analogues or tacrolimus or known sensitivity to these agents * anticancer treatment (chemotherapy, radiotherapy) within 4 weeks prior to randomization * ongoing toxicity associated with prior anticancer therapy * inadequate recovery from any prior surgical procedure or having undergone any major surgical procedure within 2 weeks prior to randomization. * another primary malignancy within the past five years (except for non-melanoma skin cancer and cervical carcinoma in situ) * known grade 3 or 4 hypersensitivity to macrolide antibiotics * significant uncontrolled cardiovascular disease * active infection * known hiv infection * known hepatitis b or c infection * newly diagnosed (within 3 months before enrollment) or poorly controlled type 1 or 2 diabetes * concurrent treatment with immunosuppressive agents * a requirement for concurrent treatment with medication that strongly induce or inhibit cytochrome p450 (cyp3a)
cerebral hemodynamics and oxygenation in critically ill patients

Conditions: Septic Shock

Summary: critically-ill patients frequently experience marked changes in mean arterial pressure and carbon dioxide partial arterial pressure, the two major determinants of the cerebral blood flow. in addition, many therapeutics (fluids, vasopressors or inotropes administration, blood transfusion, prone positioning...) can influence these two determinants of cerebral blood flow and thus cerebral blood flow, especially in patients with altered cerebral autoregulation. nevertheless, cerebral hemodynamics and oxygenation, as well as the effects of the different therapeutics on it have been poorly studied in critically-ill patients. in addition, it has been suggested that impaired cerebral blood flow and impaired cerebral microcirculation may be involved in the pathophysiology of septic encephalopathy in patients with sepsis and/or septic shock. in this study, we aimed to characterize and investigate the effects of different therapeutics on cerebral hemodynamics and oxygenation in critically-ill patients.


Eligibility criteria:
inclusion criteria : * patients under mechanical ventilation and sedated within the first 72h of ventilation onset * indication to one of the studied therapeutics left at the discretion of the attending physician exclusion criteria * age \< 18 years * pregnancy * inability to obtain a doppler signal * medical history or clinical evidence of neurological disease * known severe carotid stenosis (\>70%) * significant cardiac arrhythmias * care-limitation decision.
determination of the effect of puzzle use in elderly patients

Conditions: Quality of Life; Surgery; Postoperative Confusion; Cognitive Dysfunction

Summary: the aim of this study is to determine the effects of the use of a simple, reliable and cost-effective puzzle on post-operative cognitive function changes, postoperative recovery, and quality of life using questionnaires and face-to-face interview techniques.

aging is a process involving biological, physiological and psychological changes. with aging, deterioration in brain, behavior and cognitive functions is observed. in this process, physical and cognitive deficiencies and slow thinking can be seen. the independence of elderly individuals in meeting their self-care decreases. over time, individuals become unable to meet their needs and this reduces the quality of life of individuals. with the developing technology, perioperative care techniques began to develop and the number of surgical procedures applied to elderly patients began to increase.one of the most important goals in the field of health today and in the future will be to increase the quality of life of individuals. it is becoming increasingly important to determine the effective factors to protect cognitive functions in elderly individuals.after surgical procedures, patients may experience memory loss and decrease in concentration. symptoms indicating a decrease in cognitive functions were named as postoperative cognitive dysfunction. compared to other individuals undergoing surgery, the rate of cognitive changes in the early period is higher in the elderly.especially, elderly patients who underwent orthopedic surgery are thought to be a risky patient group for postoperative cognitive impairment.solving jigsaw puzzles is a low-cost, motivating, visuospatial cognitive-challenging activity.this study will be conducted in order to determine the effect of this strain on the cognitive functions of the individual and to investigate the effect of focusing on completing the puzzle on post-operative recovery and quality of life, as it will focus the individual's perception on a certain point.

Eligibility criteria:
inclusion criteria: * 65 years and older, * having been hospitalized in the orthopedic service for at least three days after the operation, * having undergone orthopedic surgery, * no hearing or vision problems, * able to communicate, * no cognitive or psychiatric problems, * at least primary school graduate, * patients who agreed to participate in the study exclusion criteria: * using jigsaw puzzles regularly, * using drugs that affect memory and thinking these drugs are: 1. sedative and hypnotic drugs * benzodiazepines * barbiturates * non-barbiturate * other sedative and hypnotics (zolpidem, buspirone, hydroxyzine) 2. anticonvulsant drugs 3. drugs used in parkinson's treatment 4. drugs used in the treatment of psychiatric diseases 5. drugs with narcotic analgesic effects 6. anesthetic drugs 7. neuromuscular blocking drugs - patients with cerebrovascular accident or head injury

Keywords: postoperative recovery, cognitive function, surgery, quality of life, elderly patient
the inflammatory burden in hemodialysis vs. peritoneal dialysis patients: the role of alpha-defensin

Conditions: Kidney Failure; Inflammation

Summary: the aim of this study is to determine the levels of alpha-defensin throughout the hemodialysis course compared to the levels at the end of a course of peritoneal dialysis, as a reflection of the inflammatory burden.


Eligibility criteria:
inclusion criteria: * kidney failure patients undergoing hemodialysis or peritoneal dialysis exclusion criteria: * active inflammatory or infectious disease