Kornimate/medical-research-clean huggingface dataset:
efficacy of korean manupuncture on pain in women with endometriosis: a parallel-group randomized controlled trial

Conditions: Endometriosis; Pain

Summary: endometriosis is defined as the presence and development of hormone-dependent endometrial tissue comprising both glands and stroma outside the endometrium and myometrium. it affects 10-15% of women of childbearing age; of these, 25% are diagnosed following a consultation for infertility, and 25% following a consultation for pelvic pain. this disease has a strong functional (pain and infertility) and organic impact, its numerous symptoms can have a considerable effect on quality of life. individualized analgesic management with multidisciplinary care (medical, surgical and psychological) can improve quality of life for women with endometriosis, but current treatment remains insufficient. korean manupuncture is a complementary treatment technique that does not interact with current treatments. it's a holistic discipline that draws up a highly detailed map of the body's correspondence on the hand. each body zone corresponds to a zone on the hand. the aim of this research is to evaluate the effect of korean manupuncture on endometriosis-related pain. patients will be randomly assigned to 2 groups, 30 to the "korean manupuncture" group and 30 to the "placebo/control" group. patients will be blinded to their assigned group.


Eligibility criteria:
inclusion criteria: * person having given oral consent * woman of legal age * woman diagnosed with endometriosis consulting for pain management exclusion criteria: * not affiliated to the national health insurance system * person under legal protection (curatorship, guardianship) * person under court order * pregnant or breast-feeding women * menopausal women (menopause is defined as amenorrhea lasting more than 12 consecutive months) * an adult unable to give consent * women who have had a hysterectomy * women who cannot speak or read french * hands not accessible for treatment * inability to follow the entire protocol * cognitive impairment
a study of ro4917838 (bitopertin) in patients with acute exacerbation of schizophrenia

Conditions: Schizophrenia

Summary: this randomized, double-blind, placebo- and active-controlled, parallel group study will evaluate the safety and efficacy of ro4917838 (bitopertin) in patients with acute exacerbation of schizophrenia. patients will be randomized to receive either ro4917838 10 mg or ro4917838 30 mg or olanzapine 15 mg or placebo orally daily for 4 weeks as inpatients, with a 4-week follow-up period.


Eligibility criteria:
inclusion criteria: * adult patients, 18-65 years of age * diagnosis of schizophrenia (diagnostic and statistical manual of mental disorders dsm iv-tr) * acute exacerbation which began within the prior 8 weeks * female patients must be surgically sterile or post-menopausal, or agree to use effective contraception for the duration of the study exclusion criteria: * current psychiatric diagnosis other than schizophrenia * alcohol or substance dependence within 3 months or abuse within 1 month (except for nicotine) * electro-convulsive therapy (ect) within the prior 6 months * previous treatment with ro4917838 or another glyt inhibitor * current treatment with olanzapine, or previous treatment with intolerability or lack of response * treatment with long-acting injectable antipsychotic within 2 dosing intervals * treatment with \> 2 antipsychotics within 3 months * history of neuroleptic malignant syndrome * have treatment-resistant schizophrenia as judged by treating physician or have failed two trials according to criteria in protocol
diagnosis and management of enhanced myometrial vascularity associated with retained products of conception

Conditions: Hypervascularized Uterine Retentions

Summary: background: hypervascularized products of conception remain a topic debated in terms of definitions (ultrasound criteria, need complement by angio mri) and management. the different uterine vascular lesions are often confused. this is a recurrent problem and care are heterogeneous. the aim of the study is to evaluate the management of these entities in chu of montpellier and determine more homogeneous care. the investigators further aimed to evaluate clinical presentation, ultrasound criteria, complications and the gynaecological and obstetrical outcomes of patients •methods: this study will be conducted in compliance of ethic comitee. the investigators will collect data from 64 individuals, aged 18 to 50, suffering from uterine vascular lesions associated or not with products of conception between 2013 and 2019. caracterisitics of the population, ultrasound and angio mri data will be collected. management wll be described as expectative, surgery or embolization of uterine arteries and the success or not will be noted. the investigators will question patients on their gynaecologic and obstetrical outcomes by telephone. •discussion: the investigators aim to define and characterize the different lesions, establish ultrasound criteria that would guide treatments. describe the current treatments and compare them in terms of efficiency and safety in order to establish a homogeneous treatment protocol in our center

* data are collected by computer software and patient phone calls * ultrasounds criteria are reviewed by two clinicians * statistical analysis is realized by a independent clinician * the consent and agreement of the ethics committee has been sought

Eligibility criteria:
inclusion criteria: * women * aged between 18 and 50 years * managed in chu montpellier * diagnosis of hypervascularized products of conception * available ultrasound pictures exclusion criteria: * subject unable to understand the study * subject with another diagnosis of bleeding * subject who have retained products of conception with no vascularity or immediate curettage with uterine vacuity * subject who have no available ultrasound pictures

Keywords: women retained products of conception, arterio venous malformation color doppler ultrasound embolization fertility
infrahepatic inferior vena cava clamping during hepatectomy

Conditions: Hemorrhage

Summary: intraoperative blood loss is a major concern during hepatic resection, as it has been shown to adversely affect patients' perioperative outcome. reduction of central venous pressure during parenchymal transection has been shown to effectively lower liver hemorrhage. while cvp reduction is mainly achieved via fluid restriction and diuretics, dehydration may impair organ function. moreover, it may lead to hemodynamic instability, particularly in case of severe bleeding. for this reason the technique of infrahepatic inferior vena cava clamping has been suggested which is able to lower cvp without the need for fluid restriction. in the present study the two strategies to reduce cvp and by this intraoperative bleeding, namely fluid restriction and inferior vena cava clamping are compared with intraoperative blood loss as primary endpoint.


Eligibility criteria:
inclusion criteria: * aged 18 years * scheduled for elective hepatic resection due to any reason * american society of anesthesiologists (asa) score i to iii * written informed consent exclusion criteria: * medical conditions exposing patient at increased risk for not tolerating liver resection: * cirrhosis (child-pugh b and c) * (hereditary) coagulopathy * medical conditions exposing patient at increased risk for not tolerating this trial's study interventions: * severe heart disease (e.g. severe cad requiring intervention, nyha iv) * pulmonary hypertension * renal insufficiency (serum creatinin \>2mg/dl or \>177µmol/l; conversion factor 88.4 or requiring dialysis) * severe hypernatremia (serum sodium \>155mmol/l) * severe hyperchloremia * for female subjects: pregnancy and lactation * impaired mental state or language problems * participation in other clinical trials or observation period of competing trials interfering with the endpoints of this trial * former participation in the clinical trial * expected lack of compliance

Keywords: elective hepatic resection due to any reason.
short-term investigation of resveratrol on fat metabolism in morbidly obese women undergoing gastric bypass surgery

Conditions: Obesity

Summary: the purpose of this study is to investigate potential metabolic effects of resveratrol in morbidly obese women undergoing gastric bypass surgery. the investigators hypothesize that resveratrol will: * decrease hepatic very-low-density-lipoprotein-triglyceride (vldl-tg) secretion * decrease hepatic and adipose tissue vldl-tg uptake * increase insulin sensitivity the investigators will look at changes in: * lipid turnover (vldl-tg kinetics, palmitate kinetics,calorimetry) * vldl-tg uptake in different tissues (subcutaneous femoral adipose tissue, subcutaneous abdominal adipose tissue, visceral adipose tissue and liver tissue) * insulin sensitivity (glucose kinetics during hyperinsulinaemic euglycaemic clamp) * regulation of liver fat handling * lipoprotein lipase activity and fat cell size (abdominal and femoral adipose tissue)


Eligibility criteria:
inclusion criteria: * female * 25-60 years * obesity (bmi \> 35 kg/m2) * have at least one element of the metabolic syndrome either hypertension and/or hypercholesterolemia (high triglyceride, low hdl-cholesterol) * undergoing gastric bypass surgery * written informed consent exclusion criteria: * any other relevant disease (e.g. diabetes, thyroid or parathyroid disease, heart, kidney or liver disease) * may have arthrosis or depression * any present or previous malignancy * history of smoking * alcohol dependency (more than 14 units of alcohol per week) * participation in studies with radioactive isotope within the last six months * hemoglobin under the normal range regarding to sex (under 7.3 mmol/l for women)

Keywords: obesity gastric bypass surgery resveratrol insulin sensitivity lipid turnover vldl-triglyceride uptake liver
effectiveness of a group intervention for the treatment of shoulder pathologies

Conditions: Shoulder Pain

Summary: the investigators determined the effectiveness of a group intervention for the treatment of shoulder pathologies.

the investigators performed a two-armed prospective clinical trial study, analyzing a sample formed by 76 patients with shoulder pain. the patients were allocated to one group randomly (intervention or control group). the data was obtained in the san juan de alicante hospital between november 2014 and july 2015.

Eligibility criteria:
inclusion criteria: -patients who came to the rehabilitation service of the san juan de alicante hospital between november 2014 and july 2015 with one of the diagnosed diseases indicated in the 726.10 icd-9-cm code (nontraumatic rotator cuff tear, bursitis, tendinitis, and medical diagnostics impingement syndrome of any severity depending stadiums neer (1990) unilateral or bilateral joint balance with free or minimally limited internal rotation). exclusion criteria: * patients who cannot perform the exercises correctly (example: psychiatry disorders) * patients with shoulder surgery * patients whose shoulder pain is above 7 according vas pain.
safety and efficacy study of de-104 ophthalmic solution to treat open-angle glaucoma or ocular hypertension

Conditions: Open-Angle Glaucoma; Ocular Hypertension

Summary: to investigate the dose-response relationship of de-104 ophthalmic solution in lowering intraocular pressure (iop) in subjects with primary open-angle glaucoma or ocular hypertension


Eligibility criteria:
inclusion criteria: * diagnosed with primary open-angle glaucoma or ocular hypertension. * provided signed, written informed consent. * if a subject is a female of childbearing potential, she must utilize reliable contraceptive throughout the study, and must have a negative urine pregnancy test prior to enrollment into this study. exclusion criteria: * females who are pregnant, nursing or planning a pregnancy, or females of childbearing potential who are not using a reliable method of contraception. * presence of any abnormality or significant illness that could be expected to interfere with the study.
study of epigallocatechin-3-gallate (egcg) for skin prevention in patients with breast cancer receiving adjuvant radiotherapy

Conditions: Breast Neoplasms; Dermatitis; Prevention & Control; Epigallocatechin Gallate

Summary: the investigators conduct this phase ii study of egcg therapy protection of the skin from damage induced by radiotherapy in breast cancer. in order to observe the effectiveness of egcg, investigators will utilize both clinician assessments and patient self-assessments. physician's skin assessments will be scored utilizing the radiation therapy oncology group (rtog) score. patient reported symptom scores are adapted from the skin toxicity assessment tool (stat) as pain, burning, itching, pulling, and tenderness in the treatment area. the scales are translated into chinese and guides in chinese are developed instructing how to use the scales and perform the assessments.


Eligibility criteria:
inclusion criteria: * age ≥ eighteen years * eastern cooperative oncology group performance status of 0-1 * normal hematologic, hepatic function and renal values * forced expiratory volume 1 \>800 cc exclusion criteria: * the presence of rash or unhealed wound in the radiation field * a known allergy or hypersensitivity to egcg * pregnancy or lactation * history of/current connective tissue disorder * prior radiation to the thorax

Keywords: breast neoplasms prevention & control epigallocatechin gallate dermatitis
effects of radial extracorporeal shock wave and kinesio taping treatments in patients with carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome (CTS)

Summary: carpal tunnel syndrome (cts) is a common upper extremity nerve compression syndrome that causes significant economic and social burden to affected individuals. although the severity may vary among patients, symptoms such as night pain, transient numbness, tingling, constant pain, muscle weakness, and sleep disturbance may be observed. the treatment of cts can be grouped as nonsurgical and surgical treatments. the aim of this study is to investigate the effects of treatment with sound waves and a healing method called extracorporeal shock wave therapy and a therapeutic flexible tape called kinesiology taping on pain, grip strength, quality of life, depression symptoms, hand functions, and ultrasonographic median nerve cross-sectional area in patients with cts.

carpal tunnel syndrome is the most common nerve entrapment syndrome, typically affecting the dominant extremity. symptoms often become more pronounced at night, and may include numbness, tingling, electric shock sensations, pain, and other related symptoms. diagnosis can be made based on patient history, physical examination, electrodiagnostic tests, and ultrasonography. treatment options include splinting, exercise therapy, physical therapy modalities, various injections, and surgical methods. in our study, we compared the effects of extracorporeal shock wave therapy (eswt) and kinesiology taping (kt) on carpal tunnel syndrome. the study involved four randomized groups: group 1 received both eswt and kt, group 2 received only eswt, group 3 received only kt, and group 4 received exercise therapy alone. evaluations were conducted using the visual analog scale, boston carpal tunnel questionnaire, douleur neuropathique 4 questions, nottingham health profile, grip strength measurements, and median nerve cross-sectional area via ultrasonography. evaluations were performed three times: before treatment, at week 3, and at week 6.

Eligibility criteria:
inclusion criteria: * mild to moderate unilateral carpal tunnel syndrome confirmed by electroneuromyography (enmg) * patients over 18 years of age * symptom duration of at least 3 months * those who have not received any medical treatment other than analgesics in the last 3 months exclusion criteria: * bilateral carpal tunnel syndrome (cts) * severe cts detected by enmg * operated cts * corticosteroid injection within the last 3 months * history of peripheral nerve damage * secondary cts causes (thyroid dysfunction, connective tissue diseases) * cervical disc herniation * dequervain tenosynovitis, trigger finger, dupuytren contracture * inflammatory disorder * bleeding disorder * pregnancy * malignancy

Keywords: carpal tunnel syndrome extracorporeal shock wave therapy kinesio taping
improving night shift nurses' health and reducing burnout

Conditions: Healthy

Summary: healthy and happy nurses are essential to ensuring optimal patient outcomes and organizational success. the evidence on the negative impacts of night shift on nurses' health and cognitive function, and their implications on patient outcomes and organizational costs, reflect the need for interventions to mitigate these detrimental outcomes. this pilot, feasibility, clinical trial will examine the feasibility of two fatigue countermeasure interventions (access to napping/relaxation room and use of blue/green light blocking glass during night shift) and explore the interventions effects on nurses' health, missed care, and burnout.

aim 1 (primary): examine the feasibility of a larger study and hospital-wide implementation of two fatigue countermeasure interventions (access to napping/relaxation rooms and use of blue/green light blocking glass during night shift). aim 2 (exploratory): explore the effects of the interventions on melatonin levels, overall health, sleep, fatigue, cognitive function, missed care, nurse burnout, and salivary melatonin levels.

Eligibility criteria:
inclusion criteria: * being a registered nurse at upmc shadyside (pittsburgh, pa) * working full-time night or rotating shifts * willing to wear a fitbit around-the-clock during the study * willing to use nap/relaxation room and glasses only when assigned to that condition * willing to provide saliva samples exclusion criteria: * having a diagnosed sleep disorder (e.g., obstructive sleep apnea, insomnia, restless leg syndrome, or shift work disorder) * currently being treated for a serious mental illness * needing to use eye glasses to complete work related activities (note: contact lenses are acceptable) * use of prescription or over-the-counter sleep aides including melatonin

Keywords: sleep fatigue burnout night shift
comparative effectiveness of hot versus cold snare polypectomy of small colorectal polyps

Conditions: Colonic Polyps; Colorectal Neoplasms; Adenoma

Summary: this study aims to investigate the comparative effectiveness between polyp removal with or without electrical current. the investigators want to include 600 polyps in the trial. it is known that polyps have the potential to develop to cancer if left in situ, but the investigators do not know the best way to remove them completely.

in this study the investigators want to compare to widely used methods for polyp removal; hot and cold snare polypectomy. there has not been performed any big studies on this subject earlier, but current knowledge indicates that hot polypectomy (i.e. with use of electrical current) is somewhat better with regard to complete resection of polyps compared to cold polypectomy (without electrical current). in this project the patients will be randomized to either hot or cold polypectomy. the investigators will distribute videos of how the polypectomies should be performed, and a gastroenterologist in the project group will instruct the doctors examining the patients to make sure that everyone performs polypectomy according to current guidelines. the study is designed as a non-inferiority trial.

Eligibility criteria:
inclusion criteria: * outpatient colonoscopy * signed, written informed consent * at least one flat/sessile polyp sized 4-9 mm identified during colonoscopy exclusion criteria: * implanted cardiac electro converter * severe comorbidity (nyha 3-4) * known coagulopathy (inr \> 1,8) or resent use of any of the new oral anti-coagulant medications * platelet count \< 100 * resent use of clopidogrel or other non-acetylsalicylic acid platelet inhibitor (last dose \< 5 days before the procedure) * previous biopsy or attempt of polypectomy of the polyp considered for inclusion in the trial
comparison between symbicort® and prednisolone in copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: to assess if symbicort forte turbuhaler (during two weeks) is as effective as an oral course of prednisolone + oxis turbuhaler (during two weeks) for the treatment of an acute exacerbation of chronic obstructive pulmonary disease (copd).


Eligibility criteria:
inclusion criteria: * patients with chronic obstructive pulmonary disease and an acute exacerbation * after the acute treatment a simple pulmonary function test shows a value of 30%-60% of the predicted normal value. * patients, who, based on the clinical examination after the initial acute treatment, are candidates for a course of oral steroids for the treatment of acute symptoms due to chronic obstructive pulmonary disease exclusion criteria: * diagnosis/history of asthma * oxygen uptake (saturation) is \<92% after the initial acute treatment * a requirement for regular use of oxygen therapy * regular treatment with any inhaled steroid \>1 000 µg/day at study entry additional inclusion and exclusion criteria will be evaluated by the investigator

Keywords: copd