Kornimate/medical-research-clean huggingface dataset:
streaming web-based exercise at home: a pilot study

Conditions: Prostate Cancer; Breast Cancer Female

Summary: this is a single-arm pilot study to evaluate the use of web-based video conferencing as a method of exercise training delivery. this study will include 10 female breast cancer survivors and 10 male prostate cancer survivors. for the first 12 weeks on study (part 1), participants will train with an exercise physiologist (ep) for 150 minutes/week. this training will be delivered by web-based video conferencing. for the next 12 weeks (part 2), participants will be instructed to do patient-directed exercise.


Eligibility criteria:
inclusion criteria: * male previously diagnosed with prostate cancer or female previously diagnosed with breast cancer. * for breast cancer, minimum of 3 months post-active treatment completion. active treatment includes chemotherapy, biologic therapy, radiation therapy, surgery, and any combination. long-term hormonal/biologic treatments are acceptable. * for prostate cancer, minimum of 3 months post-active treatment completion. active treatment includes chemotherapy, biologic therapy, radiation therapy, surgery, and any combination. long-term hormonal/biologic treatments are acceptable, except for androgen receptor-targeted therapies (such as enzalutamide, apalutamide, darolutamide, or abiraterone). patients currently on active surveillance are eligible even if they have not received prior anti-cancer treatment. * has access to tablet, laptop, or desktop computer with video capabilities connected to the internet with a screen at least 13 inches across. * physically able to complete modified bruce submaximal treadmill test, leg strength test, grip strength test, and inbody per patient self-assessment. * physician clearance to participate in this study. can be done through review of patients' medical records. * ability to read, write, and understand english. * has a chair at home to use for exercise that is not on wheels and has a solid back (not a reclining chair). * ambulatory without assistance. * has a clear 5 x 6-foot space at home in which to exercise. * age \>18 years. * written informed consent obtained from subject and ability for subject to comply with the requirements of the study. exclusion criteria: * active treatment planned within the next 6 months. active treatment includes chemotherapy, biologic therapy, radiation therapy, surgery, and any combination. long-term hormonal/biologic treatments are acceptable, except for ar-targeted therapies for prostate cancer. * known metastatic disease. * grade 3 or higher peripheral neuropathy. * major surgery within 3 months of baseline visit. * positive pregnancy test for women of child-bearing potential. * answers yes to any question on the physical activity readiness questionnaire unless study participation is cleared by a physician. * known allergy to fitbit device. * currently meeting physical activity guidelines (score of \>23 on godin-shephard leisure-time physical activity questionnaire).

Keywords: exercise breast cancer survivor prostate cancer survivor
effect of alexander technique on neck pain and quality of life in lactating women

Conditions: Neck Pain

Summary: this study will be conducted to investigate the effect of the alexander technique on neck pain and quality of life in lactating women.

during breastfeeding, incorrect positioning and placement of hands to support the baby's weight can irritate the musculature of the hands. repeating the same position frequently can lead to radiating pain in the elbows and hands. additionally, adopting different postures to compensate for the pain while sitting, standing, or lying down can cause mechanical changes in the cervical, thoracic, and lumbar spine, altering the body's correct posture. the alexander technique is a non-exercise approach focused on improving the modulation of postural muscle activity. it offers an individualized approach to developing skills that help people recognize, understand, and avoid poor habits that affect postural tone and neuromuscular coordination. its lessons are associated with clinically relevant long-term reductions in neck pain and disability. some previous studies examined effect of alexander technique on neck pain and on quality of life in different population, but in our knowledge this is the first study will be conducted to investigate effect of alexander technique on neck pain and quality of life in lactating women, so this study will be conducted to provide an insight about the beneficial effect of the alexander technique on neck pain and quality of life in lactating women which will be of valuable benefits in the women's health field.

Eligibility criteria:
inclusion criteria: * lactating females experiencing neck pain (six weeks to 1year postpartum). * able to understand and follow the alexander technique instructions. * their age will be ranged from 20-35 years old. * their bmi will be less than 30 kg/m2 . * their pain level is ≥ 4 on numeric pain rating scale. * they have mild disability on neck disability index questionnaire (ndi). * they have limited cervical range of motion (the normal flexion range of motion is 80° to 90°, extension 70°, lateral flexion 20° to 45°, and rotation up to 90°). exclusion criteria: * neck pain as consequence of disc protrusion or prolapse, whiplash, congenital deformity of the spine, spinal stenosis, neoplasm, inflammatory rheumatic disease, neurological disorder, and psychosis. * women who had invasive treatment of the spine within the previous three weeks, or spinal surgery or presence of neck history of trauma. * presence of contraindications to spinal movement, such as fracture or dislocation.
psycho-emotional impact of preoperative counselling in cervico-carcinoma screening programs

Conditions: Physiological Stress; HPV Infection; Papilloma Viral Infection

Summary: the communication of an altered pap smear or positive hpv test has a strong impact on patients on a psychological level. hpv positive women are more likely to have higher level of stress, anxiety, depression and impaired sexual life. the examiner want to establish this impact through different surveys (dass-21 (depression anxiety stress scales); pcl-5 (posttraumatic stress disorder checklist); dts (dyadic trust scale), cddq (cervical dysplasia distress questionnaire) and mpi (match patient inventory) from the moment the patient receives the news until after completing treatment for her intraepithelial neoplasia.


Eligibility criteria:
inclusion criteria: * patients accessing our colposcopy service from prevenzione serena program with an altered pap smear or a two-times positive hpv test * patients with biopsy result of hsil * ability to fill in surveys via e-mail exclusion criteria: * previous access in our colposcopy service * patients not enrolled in prevenzione serena * pregnant patients * inability to fill in surveys via email * partial or total language barrier * denied consent to participate
prospective evaluation of aeromedical ems ultrasound in major trauma victims

Conditions: Major Trauma Patients

Summary: the purpose of this study is to investigate the use of ultrasound by aeromedical prehospital providers.

this study will be divided into three parts. the first portion involves the education/inservices of the aeromedical prehospital providers to document the knowledge and skills necessary to perform and interpret efast exams using ultrasound pre hospitalization. the second portion involves testing the logistics of utilization of prehospital ultrasound. data will be collected by the participating aeromedical prehospital providers to rate the durability of the equipment, difficulty in preforming the efast exam, interference with other actions and ability of retention of images. the third portion will involve the aeromedical prehospital providers performing the efast exam using the ultrasound prehospital and comparing their findings with the gold standard exam, ct scan, while patient is in the emergency department.

Eligibility criteria:
inclusion criteria: * code 3 trauma activation admitted directly from scene transported via life flight (aeromedical ambulance) exclusion criteria: * transfer from outside hospital

Keywords: code iii trauma (highest acuity) life flight aeromedical ambulance service
factors affecting medical student learning in simulation scenarios

Conditions: Learning

Summary: simulation is used to teach undergraduate and postgraduate healthcare professionals, however it is not known how best to use this resource. using qualitative methods, this study aims to investigate how medical students learn during simulation scenarios and will compare students who are paired with peers with those who are solo during their scenarios. video and audio data from simulations will be collected and analysed with anxiety and empathy questionnaire data and semi-structured interviews.

medical students attending a simulation day will either perform their simulation paired with another student from the group or solo. video data from the scenario and audio data from the feedback session will be retained. one week later students will perform a second scenario and the feedback following this will be retained. students will also have a semi-structured interview and complete anxiety and empathy questionnaires.

Eligibility criteria:
inclusion criteria: * all final year medical students at the study university who are allocated to attend the anaesthesia special study module exclusion criteria: * non-english speakers * visiting students who will be unable to complete the study * students who refuse to participate

Keywords: simulation learning medical students empathy anxiety
risperidone treatment in dually-diagnosed individuals - 2

Conditions: Cocaine-Related Disorders

Summary: the purpose of this study is to evaluate the safety and efficacy of risperidone for cocaine dependence in individuals with schizophrenia/schizoaffective illness.


Eligibility criteria:
please contact site for information.

Keywords: cocaine dependence
efficacy of the sleeve gastroplasty with the endoscopic system overstich sx on weight loss and reduction of co-morbidity for obese patients

Conditions: Obesity

Summary: the overstitch ™ sx system (apollo endosurgery inc., austin, tx, usa) is a new generation of endoscopic suturing device. it is inserted into an endoscope allowing the approximation of luc karsentys soft tissue by placement of sutures. it is as effective a suture system as a surgical system. the overstitch ™ sx allows suturing in the upper and lower gi with a flexible single channel endoscope. previously, the ™ overstich was only compatible with an olympus dual channel endoscope. thus, a wide range of interventions are possible, including gastric endoplastic sleeve (esg), rygb revision, anastomotic fistula repair and / or sleeve revision. in each of these indications, the overstitch (overstitch) ™ system has shown its effectiveness and safety. the overstitch endoscopic ™ suture system allows the entire digestive wall to be sutured through a flexible endoscope. thus, a wide range of interventions are possible, including gastric pocket repair after gastric bypass surgery, anastomotic fistula repair, endoscopic treatment of digestive perforation, and endoscopic sleeve surgery. in each of these indications, the overstitch system has demonstrated its effectiveness and safety. but this technique is recent, especially in france. in addition, no data has yet been released regarding the new overstitch ™ sx device compatible with all single channel endoscopes. an observational study including patients in french centers that are experts in therapeutic endoscopy seems essential to us to better assess this new device and this new technique in practice


Eligibility criteria:
inclusion criteria: * patient over 18, male or female * patient with obesity with a bmi\> 30 or bmi\> 40 (if surgery contraindicated or refused by the patient) * patient with a weight gain after sleeve gastroplasty or sleeve gastrectomy * informed and written consent of the patient obtained * complete clinical examination * lack of participation in another clinical study * patient able to follow, understand the study and answer the questionnaire exclusion criteria: * haemorrhagic disease, haemostasis and coagulation disorder and platelets \<60000 / mm3). * breastfeeding women * toxicomany, alcoolism * patient known for gastric lesion requiring surveillance or familial history of gastric neoplasia * hiatus hernia\> 4 cm high
a single dose trial of recombinant factor viii (n8) in japanese subjects with haemophilia a: an extension to trial nn7008-3543

Conditions: Congenital Bleeding Disorder; Haemophilia A

Summary: this trial is conducted in japan. the aim of this clinical trial is to investigate the pharmacokinetics (the effect of the investigated drug on the body) and safety of turoctocog alfa (recombinant factor viii (n8)) in japanese subjects with haemophilia a.


Eligibility criteria:
inclusion criteria: * japanese subjects who have completed nn7008-3543 * no detectable inhibitors to factor viii exclusion criteria: * congenital or acquired coagulation disorders other than haemophilia a * planned surgery during the trial period * receipt of any investigational drug other than recombinant factor viii (n8) within 30 days of trial product administration
developing an integrated system approach for the management of hypertension: a pilot study

Conditions: Hypertension

Summary: hypertension has become a public health concern worldwide due to its significant contribution to the global health burden and its role as a prominent risk factor for the development of a number of chronic diseases such as cardiovascular diseases (cvd), the leading cause of mortality in pakistan and worldwide. according to who, about 7.5 million deaths worldwide is attributable to hypertension i.e. about 12.8% of the total of all deaths. this accounts for 57 million disability adjusted life years (dalys) or 3.7% of total dalys. studies suggest that hypertension is among the top five most common presenting complaints to private general practice clinics. therefore, primary care physicians/family physicians are the first line service providers and; thus it is important to manage hypertensive patients early, through lifestyle and treatment interventions that may prevent the complications such as development of cvds etc.

to the best of authors' knowledge limited evidence is available from pakistan on management of hypertension through an integrated approach. therefore, the aim of the trial is to develop a health delivery system that effectively manages hypertension at primary care level. hypothesis: the development of an integrated management approach will be effective in managing hypertension at all levels among hypertensive patients.

Eligibility criteria:
inclusion criteria: * individuals aged 40 years or over visiting the selected ims centre with known hypertension or with consistently elevated bp on two separate visits (mean of last two of three measurements of systolic pressure ≥140 mm hg or mean diastolic pressure ≥90 mm hg) or already receiving treatment will be eligible for inclusion in the study. exclusion criteria: * those patients who require intensive care unit or coronary care unit admissions, or are diagnosed to have cognitive impairment, are agitated due to severe pain, non-resident of karachi, or having language barrier will be excluded from the study. * a screening form will be designed for the collection of the above mentioned information. the rationale of excluding all the participants with above mentioned condition is that the participants having these health concerns will either not be able to respond to our questionnaire or their presence may confound our results.

Keywords: hypertension uncontrolled hypertension
evaluating the safety and efficacy of proellex® in premenopausal women with symptomatic uterine fibroids

Conditions: Uterine Fibroids

Summary: premenopausal women with symptomatic uterine fibroids will be randomized to either proellex 25mg or 50mg or placebo for one treatment cycle (four months). safety and effectiveness between 50 mg versus placebo, and between 25mg and placebo will be analyzed.

subjects with documented uterine fibroids, screening ufs-qol severity score of at least 40, and meeting other eligibility criteria will be enrolled in the study. following screening and a pre-treatment endometrial biopsy, subjects will be assessed monthly for the four (4) month double-blinded treatment phase. the study duration is approximately six months, comprised of a one-month screening period, 4 month treatment period and one month follow-up period. subjects' blood will be drawn in a fasting state to obtain the pre-dose trough (pk) levels of study drug at each study drug dosing/dispensation visit to determine the potential for drug accumulation.

Eligibility criteria:
inclusion criteria: * speak, read and understand english or spanish; * not have undergone hysterectomy, uterine arterial embolization or endometrial ablation therapy (previous myomectomy is acceptable) for any cause and no surgical interventions for uterine fibroids (e.g. hysterectomy, myomectomy, uterine arterial embolization) are planned or anticipated during the study; * one uterine fibroid must be identifiable and measurable by transvaginal ultrasound; * menstrual cycle lasting from 24 to 36 days; * history of excessive menstrual bleeding; * negative urine pregnancy test at screening. exclusion criteria: * six months or more (immediately prior to screening visit) without a menstrual period; * prior hysterectomy; * prior bilateral oophorectomy; * pregnant or lactating females or women who are attempting or expecting to become pregnant at any time during the study; * documented endometriosis, active pelvic inflammatory disease (pid), platelet dysfunction, or von willebrand's disease; * any history or diagnosis of gynecological cancer or cervical dysplasia of any grade including atypical squamous cells of undetermined significance (ascus) associated with human papilloma virus (hpv); * subject with diagnosed or suspected carcinoma of the breast, reproductive organs or any other organ system; * subject with known active infection with hiv, hepatitis a, b or c, gonorrhea, or chlamydia or previous history of auto-immune disease or positive serum antinuclear antibodies.

Keywords: uterine fibroids
the study of cardiovascular outcomes in women with preeclampsia using echocardiography: the scope study

Conditions: Preeclampsia

Summary: this study will evaluate the differences in cardiovascular parameters between women with severe preterm preeclampsia and those without preeclampsia using echocardiography and maternal blood. the investigators will also look at associations of abnormal cardiovascular findings and immediate complications among a high risk cohort of pregnant african american women.

this will be a prospective cohort study. exposed cases will be admitted to the inpatient obstetrical unit (labor \& delivery or antepartum unit) at the hospital of the university of pennsylvania with concern for severe preterm preeclampsia. unexposed controls will be matched by gestational age and other clinical factors and will be obtained from the outpatient setting (helen o dickens clinic or penn obgyn associates at 3701 market street). the investigators will compare cardiovascular risk factors between these two groups.

Eligibility criteria:
exposed cases: inclusion criteria: * african american women who are admitted to the obstetrical unit with a concern for severe preeclampsia. patients must be preterm (23-36 6/7 weeks) with a live singleton gestation and at least 18 years old. women will baseline chronic hypertension and women on magnesium will be included. exclusion criteria: * non-african american women, and african women with concern for severe preeclampsia who are admitted 23 weeks or 37 weeks. women in labor will be excluded. women with preexisting cardiovascular disease and women who are current smokers will be excluded. unexposed controls: inclusion criteria: * african american women obtaining prenatal care in our outpatient setting who meet matching criteria as noted above. exclusion criteria: * non-african american women and women who are not receiving care at our institution. * all women who do not speak english and who are unable to be consented will be excluded.
a study to evaluate the effect of analgesics on a walking model of knee pain (0000-105)(completed)

Conditions: Osteoarthritis

Summary: this study will evaluate a walking model of osteoarthritis for use in testing of new therapeutic agents. the primary hypothesis is that participants treated with naproxen or ultracet will have lower pain intensity (pi) than those treated with placebo during self-paced walks on day 3 of treatment.


Eligibility criteria:
inclusion criteria: * has osteoarthritis of the knee and primary source of pain is knee * females must not be pregnant or nursing and must agree to use birth control throughout the study * is willing to limit alcohol and caffeine intake * is willing to abstain from smoking during study visits * must be able to walk on a treadmill at a pace of at least 1 mile/hour exclusion criteria: * has a medical/arthritic disease that would interfere with evaluation * is unable to take naproxen or ultracet * has congestive heart failure or angina * has a history of stroke * has a history of uncontrolled high blood pressure * has a history of cancer * regularly uses a walker or cane