Kornimate/medical-research-clean huggingface dataset:
adult intensive care units database of national taiwan university hospital

Conditions: Critical Illness

Summary: australian and new zealand intensive care society (anzics) has built an center of outcome and resource evaluation (core) adult patients database (apd) of adult critically ill patients. anzics core apd has built an international collaboration of intensive care unit (icu) database. national taiwan university hospital has joined this international collaboration and built the data according to the apd data dictionary with same value domain attributes and data element attributes. this database also add expansion of data include hourly vital signs data, more laboratory data, more diagnoses at admission and discharge, data after 24 hours till discharge, and extended information of clinical outcomes more than 30 days after admission to icu . this database will retrospectively collect the data of patients discharged from intensive care after march 1, 2019 and will prospectively continue the retrospective collection of data till the patients discharged before june 30, 2043. the data will be used for the evaluation of quality and resource allocation, quality improvement, education of data science, datathon, and research to predict the clinical outcomes and assist the treatment strategies.


Eligibility criteria:
inclusion criteria: * critically ill patients admitted to intensive care units exclusion criteria: * patients aged less than 20 years
a study to evaluate the safety & effectiveness of a nasal spray to treat seasonal allergies

Conditions: Seasonal Allergic Rhinitis

Summary: the purpose of this study is to determine if one allergy medication (0.15% azelastine hydrochloride) is more effective than placebo alone


Eligibility criteria:
inclusion criteria: * male and female patients 12 years of age and older with a 2 year history of moderate to severe seasonal allergic rhinitis * must be in generally good health * must meet minimum symptom requirements, as specified in the protocol * must be willing and able to provide informed consent and to participate in all study procedures * positive skin test to a prevalent fall allergen exclusion criteria: * on focused nasal examination, the presence of any nasal mucosal erosion, nasal ulceration, or nasal septal perforation at either the screening visit or randomization visit will disqualify the subject from the study. * other nasal disease(s)likely to affect deposition of intranasal medication, such as sinusitis, rhinitis medicamentosa, clinically significant polyposis, or nasal structural abnormalities. * nasal surgery or sinus surgery within the previous year * chronic sinusitis-more than 3 episodes a year * planned travel outside of the study area during the study period * the use of any investigational drug within 30 days prior to screening. no investigational products are permitted for use during the conduct of the study. * presence of any hypersensitivity to drugs similar to azelastine and to either sorbital or sucralose (splenda brand sweetener) * women who are pregnant or nursing * women of childbearing potential who are not abstinent or not practicing medically acceptable method of contraception * respiratory tract infection within 14 days prior to screening * respiratory tract infections requiring antibiotic treatment 14 days prior to screening * asthma (with the exception of mild, intermittent asthma). subjects with mild, intermittent asthma who only require short-acting inhaled bronchodilators (not for more often tha twice a week) and who do not have nocturnal awakening as a result of asthma are eligible for enrollment * significant pulmonary disease including copd * clinically significant arrythmia or symptomatic cardiac conditions * a known history of alcohol or drug abuse within the last 2 years * existence of any surgical or medical condition or physical laboratory findings, which in the opinion of the investigator or sponsor's medical monitor, might significantly alter the absorption, distribution, metabolism, or excretion of study drug; that might significantly affect the subject's ability to complete this trial; or their safety in this trial * clinically relevant abnormal physical findings which, in the opinion of the investigator, would interfere with the objectives of the study or that may preclude compliance with the study procedures.
effects of deep breathing excercises with and without pmr on depression & qol in females with hystrectomy

Conditions: Post-Hysterectomy Vaginal Vault Prolapse

Summary: to find out the effects of deep breathing exercises with and without progressive muscle relaxation technique on depression and quality of life in females with hysterotomy


Eligibility criteria:
inclusion criteria: * age 35-55 * females gone through all types of hysterotomy * hysterotomy done due to heavy menstrual bleeding, fibroids, pelvic pain, endometriosis and map ( morbidly adherent placenta ). exclusion criteria: * females with hormonal replacement therapy * any history of cancer * diagnosed patient of any psychiatric illness

Keywords: depression, hysterectomy, progressive muscle relaxation technique
quality of life in head and neck patients

Conditions: Head and Neck Cancer

Summary: evaluation of health-related quality of life of head and neck cancer patients undergoing immunotherapy

introduction: the treatment of head and neck neoplasms, as well as the evolution of the disease, can affect a variety of body functions, including breathing, swallowing and speech, with great potential to cause various physical, emotional, and social problems to the patient, leading to considerable impairment of their quality of life. several instruments were developed to measure this variable. such evaluation is currently considered fundamental to report therapeutic results, but there is no consensus regarding the instrument to be employed. the university of washington questionnaire has been the most widely used so far. eortc (european organization for cancer research and treatment) recently published a new questionnaire specifically for patients treated for head and neck cancer (eortc qlq-h \& n43), already validated in portuguese for brazil. objectives: the aim of this prospective and multi-institutional study is to evaluate the quality of life of patients with metastatic head and neck cancer undergoing immunotherapy in different regions of brazil. other endpoints will also be evaluated such as disease-free survival and overall survival. procedures: eortc qlq-30 and eortc qlq-h \& n43 questionnaires, validated in portuguese for brazil, will be applied to all patients with metastatic head and neck neoplasms undergoing immunotherapy at participating institutions. these will be evaluated before the beginning of the treatment and then every 2 months, for an estimated period of 2 years or until death or on demand, in case of symptomatology that justifies it.

Eligibility criteria:
inclusion criteria: patients with a diagnosis of recurrent or metastatic squamous cell carcinoma of the head and neck region, whose planned treatment is immunotherapy, will be included. we will consider, separately, patients that had been treated with platinum before (platinum-refractory) and patients that were not submitted to this treatment (platinum naïve). primary site: patients with primary pharyngeal tumors (oro or hypopharynx), oral cavity and larynx will be included. exclusion criteria: * patients with cognitive impairment that prevents the proper application of questionnaires * brain metastasis * autoimmune disease * systemic immunosuppressive treatment * hepatitis b, c or hiv infection * prior immunotherapy

Keywords: head and neck immunotherapy quality of life
pain management following sinus surgery

Conditions: Nasal Sinus; Inflammation; Opioid Abuse; Pain, Postoperative

Summary: this study evaluates the effect of adding non-steroidal anti-inflammatories (nsaids) to the post-operative pain management of sinus surgery patients and wether or not this addition reduces or eliminates the need for narcotic pain medications. patients will be instructed to take an nsaid regimen after surgery and will be instructed to take narcotics only for breakthrough pain.

national attention has been given to the concerning rise of opioid abuse in this country, with prescriptions for this medications more than quadrupaling in the last 17 years. little is known as to the appropriate use of opioid analgesics in the post-operative recovery of patients undergoing sinus surgery. furthermore, most pain protocols include only tylenol based opioid analgesics. no study has prospectively evaluated the volume of use of tylenol based opioid analgesics and whether the addition of nsaids decreased the need for opioid analgesics. this study will compare opioid use with and without the addition of nsaids following sinus surgery. post-operative opioid use is a great public health concern, relatively unstudied, and an area with an opportunity for potential intervention to significantly reduce risks, morbidity, and mortality to our postoperative patients by better formulating a postoperative pain management plan using evidence-based practices. appropriate opioid prescribing practices can reduce the risk of addiction, drug overdose, death, and undertreated pain. by optimizing post-operative pain management protocols, the need for opioids following sinus surgery should be minimized.

Eligibility criteria:
inclusion criteria: • all patients age 18-65 undergoing functional endoscopic sinus surgery +/- nasal airway surgery (septoplasty and/or inferior turbinate reduction). exclusion criteria: * not taking anti-coagulation medications including aspirin * clinical diagnosis of aspirin-exacerbated respiratory disease * clinical diagnosis of cystic fibrosis * clinical diagnosis of primary ciliary dyskinesia * inclusion of a draf iii frontal sinusotomy * clinical diagnosis of liver/kidney failure * clinical diagnosis of thrombocytopenia * clinical diagnosis of poorly controlled hypertension * clinical diagnosis of recent gi ulcers or gastritis * clinical diagnosis of chronic pain as defined by a narcotic prescription with 6 months or involvement in a pain management program * clinical diagnosis of primary headache disorder * the use of nasal decongestants in the post-operative period. * the use of nasal packing or absorbable biomaterials.

Keywords: nsaids post-operative pain post-operative hemorrhage functional endoscopic sinus surgery
prevention of persistent alopecia following docetaxel by means of scalp cooling

Conditions: Alopecia; Breast Cancer

Summary: persistent alopecia following adjuvant docetaxel for breast cancer is a side-effect that has been recently described. this pilot trial explores the capacity of a cooling cap (elasto-gel) to prevent persistent alopecia in breast cancer patients treated with adjuvant docetaxel regimens.

persistent alopecia following adjuvant docetaxel for breast cancer is a side-effect that has been recently described. docetaxel is toxic to skin and skin annexes and can produce nail toxicity and persistent alopecia. nail toxicity has been successfully prevented by means of hypothermic gloves and slippers (elasto-gel, southwest technologies, inc, north kansas city, mo). this pilot trial explores the capacity of a cooling cap (elasto-gel) to prevent persistent alopecia in breast cancer patients treated with adjuvant docetaxel regimens.

Eligibility criteria:
inclusion criteria: * age 18-75 * breast cancer stages ii-iii * adjuvant or neoadjuvant chemotherapy with docetaxel regimens (tac or anthracyclines followed by docetaxel 100 mg/m2 x 4) exclusion criteria: * contraindications for adjuvant docetaxel and or anthracyclines

Keywords: persistent alopecia docetaxel breast cancer
new therapeutical perspectives in cases of phonological disorders

Conditions: Speech Sound Disorders

Summary: the aim of this study is to verify phonological and auditory aspects of children submitted to traditional phonological therapy, phonological therapy using a software and placebo therapy in children with phonological disorders.

the study will provide different therapeutic approaches for cases of phonological disorders, the classical approach would be mediated by cycles model, innovated approach is performed by means of an intervention speech software-sifala, there will still be the group that does not receive any of the proposals therapies that will be the placebo group.the study will provide 25 sessions for each group, with 30 minutes in each group. at the end of these sessions, the placebo group will receive one of the therapeutic approaches. with these three study groups, the investigators understand in what manner to obtain correct sounds is more effective.

Eligibility criteria:
inclusion criteria: * parents/guardians and child agree to participate and have signed the informed consent form; * have age between 4:0 to 8:11 (years:months); * present diagnosis of phonological disorders; * present hearing thresholds within the normal range exclusion criteria: * present neurological impairment, emotional and/or cognitive clearly diagnosed, or have complaint; * present any degree of hearing loss is the type conductive, mixed or sensorineural, and middle ear disorders in time of selection, as well as having presented otitis complaints; * present language impairment associated with speech sound disorder; * present commitment in the stomatognathic system that can interfere in the speech production; * have been received speech and language therapy before.

Keywords: speech speech therapy speech sound disorders phonological disorders auditory perception
tonsillectomy versus tonsillotomy in the treatment of recurrent acute tonsillitis

Conditions: Tonsillitis Recurrent

Summary: background: recurrent acute tonsillitis (rt) is a frequent condition affecting teenagers and adults. patients suffer from recurring throat symptoms, fever and impaired quality of life (qol). tonsillectomy (te) is the only well-known treatment, but studies indicate that tonsillotomy (to) is associated with less morbidity (eg. pain and bleeding) and equal efficiency (e.g. reduced number of sore throat episodes and improved qol). the investigator aim to clarify whether to is a non-inferior alternative to te. methods: inclusion and randomization of 250 adult rt patients for te or to with a 12 month follow up. comparisons will be made between groups, and outcome measures includes number of sore throat episodes, qol and postoperative pain. discussion: the study has the potential to improve the treatment of a prevalent disease by enhancing knowledge of an alternative procedure (to) associated with less discomfort and risk than the current standard procedure (te) and a presumably low risk of insufficiency.


Eligibility criteria:
inclusion criteria: * adults (age ≥15 years) with rt, defined as a minimum of five tonsillitis episodes in one year or a minimum of three tonsillitis episodes per year for two years (danish national guidelines criteria * the ability to understand danish orally and in writing. exclusion criteria: * previous te or to. * suspected tonsillar malignancy. * history of malignant tumor in the oral cavity, the pharynx or the larynx. * previous radiation therapy on head or neck. * hemorrhagic diathesis or anticoagulant therapy.

Keywords: tonsillectomy tonsillotomy quality of life
effect of iron source on the growth of enteric pathogens

Conditions: Iron-deficiency; Iron Deficiency Anemia; Iron Deficiency Anemia Treatment

Summary: the world health organization recommends daily iron supplementation for infants and children (6 months-12 years). based on the low cost and high bioavailability and efficacy, ferrous sulfate is typically the first choice for supplementation and fortification. the recommended dose of iron is set high to deliver adequate absorbed iron due to low rates of dietary iron absorption, which is typically \<10%. thus, the majority of dietary iron is not absorbed and travels to the colon. unabsorbed iron in the colon may select for enteric pathogens at the expense of beneficial commensal bacteria and increase infection risk, including the clinical incidence of diarrhea. the objective of this study is to compare the effects of iron as ferrous sulfate (feso4) or feso4-enriched aspergillus oryzae (ao iron) on the growth and virulence of common enteric pathogens using an in vitro fecal fermentation model. stool samples will be collected from children following ingestion of an iron supplement as either feso4 or ao iron. stool samples will be spiked with common enteric pathogens and outcome measures will be determined following in vitro fecal fermentation.


Eligibility criteria:
inclusion criteria: * healthy children 5-12 y * willing to donate stool sample exclusion criteria: * currently taking antibiotics * currently taking a vitamin and mineral supplement containing iron * wards of the state, including children in foster care
accurate screening tools for dysphagia in amyotrophic lateral sclerosis (als)

Conditions: Amyotrophic Lateral Sclerosis

Summary: individuals with th amyotrophic lateral sclerosis are at high risk for swallowing impairment (dysphagia) which leads to malnutrition, decreased pulmonary health, aspiration and aspiration pneumonia. these sequelae necessitate timely identification of at risk individuals to ensure optimal management of oral intake and pulmonary function. the purpose of this study is to evaluate the discriminant ability of several non-invasive screening tools at detecting swallowing impairment in individuals with als.

this research study is being performed to determine how accurate different screening tools or tests are at identifying swallowing problems associated with amyotrophic lateral sclerosis (als). as a participant one evaluation will be performed at the university of florida swallowing systems core laboratory located at shands hospital, gainesville will take place. this will take approximately two-hours. during this evaluation an videofluoroscopy (x-ray of swallowing), cough tests, tongue function test and questionnaires will be completed.

Eligibility criteria:
inclusion criteria: * diagnosis of probable or definite als exclusion criteria: * allergies to barium or capsaicin * tracheotomy or mechanical ventilation * absence of diaphragmatic pacer * respiratory disease (copd).
f-18 fdg pet/ct and ct in initial staging of non-small lung cancer

Conditions: Lung Cancer

Summary: is to compare f-18 fdg pet/ct to routine ct in staging of non-small lung cancer and effect on change management.

* the optimal treatment of non-small cell lung cancer (nsclc) relies on accurate disease staging that is based on the tnm system which relies on tumor size, regional nodal involvement, and the presence of metastasis. * ct is the standard modality used to assess the intra-thoracic spread but false negative ct scans have been reported and were related to the presence of metastasis in normal sized lymph nodes and false positive findings have been related to lymph node enlargement due to benign process. pet is most widely used in thoracic oncology because of its superiority over other imaging techniques in staging nodal and metastatic disease, however, the poor anatomic details of pet can lead to errors in diagnosis and staging. • to solve this problem, ct is combined with pet to provide matched morphological and functional data. the diagnostic capability of pet/ct in the preoperative staging of lung cancer is superior to that of ct alone and pet alone as it has the advantage of a more accurate assignment of tumor stage (t stage) and defining the lymph node stage (n stage) as well as reduction of the number of useless thoracotomies

Eligibility criteria:
inclusion criteria: * patients with pathologically proven nsclc who underwent initial pet/ct images. * all patients ≥ 18 years. exclusion criteria: * patients who had started treatment before initial pet/ct. patients with glucose level \< 200 mg/dl. patients with another malignant condition.
treatment with intravitreal avastin for large uveal melanomas

Conditions: Uveal Melanoma

Summary: the purpose of this study is to test the safety and effectiveness of avastin introduced into the inside of the eyeball in causing shrinkage of the uveal melanoma (tumor of the eye). avastin is an anti-cancer drug specially designed to shrink blood vessels within tumors.


Eligibility criteria:
inclusion criteria: * patients diagnosed with large uveal melanomas who elect to undergo enucleation. * patients diagnosed with uveal melanomas with tumor thickness \> 10 mm or basal diameter \> 16 mm, as measured by ultrasound examination, funduscopic examination, or transillumination. exclusion criteria: * cases that do not meet the above criteria for tumor size will be ineligible to participate in the study. * patients with history of metastatic cancer (other than melanoma). * patients not able to provide consent for the study. * patients with clinical or radiographic evidence of extraocular extension of the tumor. * patients with a previous history of an adverse reaction to intravitreal injection. * patients with a poor view of the fundus due to cataract or vitreous hemorrhage. * patients with intravitreal silicone oil or gas tamponade. * patients \< 18 years of age. * women known to be pregnant.

Keywords: melanoma eye avastin
efficacy of rezum® in reducing prostate volume

Conditions: Benign Hyperplasia of Prostate

Summary: this study aimed to assess the efficacy of rezum® water vapor therapy in reducing prostate volume in patients aged 40 years or older with benign prostate hyperplasia (bph) at unibe hospital in costa rica. a retrospective analysis will be conducted on 289 patient records, focusing on prostate volume, international prostate symptom score (ipss), and urinary flow rate. statistical analyses included two-sample mean comparisons, effect size estimation, and linear regression.

abstract: aim to estimate the effect size of the prostate volume reduction after application of water vapor injections (rezum®) in 40 years or older patients, that have been diagnosed with benign prostate hyperplasia (bph) and are registered at unibe hospital. this contrast provides a retrospective efficacy of the minimally invasive treatment valid for the local population. methods: a retrospective study will be conducted to review patient records, attended at unibe hospital, in costa rica. prostate volume was established as the main variable to assess bph reversion. other variables like the international prostate symptome score (ipss) and urinary flow rate were also evaluated for each patient. two sample mean comparisons of baseline and follow up measures for prostate volume and ipss will be calculated to estimate a mean difference. effect size parameters like cohen's d, hedges's g and glass's delta were also estimated and compared based on the standard deviation assessment. a linear regression model will also adjuste to obtain values of the statistical contribution from each of the variables included to evaluate the clinical reversal of a benign prostate hyperplasia diagnosis.

Eligibility criteria:
inclusion criteria: * men who received rezum therapy * men who have been treated at the unibe hospital in urology by dr. gonzález exclusion criteria: * patients without complete data for the previous variables

Keywords: prostate urology ipss score clinical efficacy rezum
sitagliptin versus glipizide in participants with type 2 diabetes mellitus and chronic renal insufficiency (mk-0431-063 am1)

Conditions: Diabetes Mellitus, Type 2; Renal Insufficiency, Chronic

Summary: the purpose of the study is to compare how sitagliptin and glipizide lower blood glucose levels in participants with moderate or severe renal insufficiency.


Eligibility criteria:
inclusion criteria: * has type 2 diabetes mellitus * has moderate or severe renal insufficiency exclusion criteria: * has type 1 diabetes mellitus or a history of ketoacidosis * is on a new weight loss program * has active liver disease * is on dialysis or is likely to need dialysis during the study