Kornimate/medical-research-clean huggingface dataset:
physical therapy management of the patient with central sensitization

Conditions: Central Sensitisation; Musculoskeletal Diseases; Pain

Summary: in the literature there is still debate about the concept of central sensitization, as a pain mechanism that can support a neuromusculoskeletal pathology and which for woolf corresponds to an amplification of neural signaling within the central nervous system causing hypersensitivity to pain. this mechanism is often confused with the concept of chronic pain, as in many conditions such as fibromyalgia, traumatic neck pain, low back pain or osteoarthritis, central sensitization supports its maintenance beyond 6 months. we believe it is important to investigate among italian physiotherapists the management of the patient in which the presence of a central pain sensitization phenomenon is suspected, in order to provide consistent data to direct the education of health professionals towards more effective management of this problem. to achieve this goal we aim to: * conduct a delphi study in order to reach consensus, into a panel of experts, on the methods useful for the management, in each phase of the physiotherapy process, of the patient with neuromusculoskeletal problems with pain underlying central sensitization mechanism * investigate, through a survey among italian physiotherapists, their clinical approach to the patient in question * develop a free online course available to clinical professionals and/or students who wish to deepen this issue.


Eligibility criteria:
inclusion criteria: * italian physiotherapists who will decide to fill in the questionnaire exclusion criteria: * no exclusion criteria

Keywords: patient management central sensitisation muscoloskeletal disease pain
effect of smartphone addiction on pregnancy

Conditions: Smartphone Addiction; Neck Disability; Stress

Summary: this study will investigate the effect of smartphone addiction on neck disability during pregnancy and its mediating role on stress. the study will be conducted between september 2023 and april 2024. data will be collected using the information form, smartphone addiction scale-short version (sas-sv), perceived stress scale (pss-10) and neck disability index (ndi). multiple regression and structural equation modeling will be used in the analysis of the data.

objective: after reviewing the relevant studies, we thought that smartphone addiction may negatively affect neck injury and perceived stress may play a mediating role in this relationship. in this context, our research questions are as follows: * do smartphone addiction and certain characteristics significantly predict stress in pregnant women? * do smartphone addiction and certain characteristics significantly predict neck injury in pregnant women? * does stress have a mediating effect on the relationship between smartphone addiction and neck injury in pregnant women? the research is a cross-sectional, analytical and screening study. the research will be conducted face-to-face with pregnant participants who apply to the pregnancy follow-up clinic of a public hospital and meet the research criteria and voluntarily participate in the research. verbal and written consent will be obtained from all participants before data collection. the principles of the declaration of helsinki will be followed throughout the study. data of the study will be collected using the information form, smartphone addiction scale-short version (sas-sv), perceived stress scale-10 (pss-10) and neck disability index (ndi). statistical analyses will be given as mean, standard deviation, median, minimum and maximum. t-tests will be used to compare categorical variables with scale scores, pearson correlation to examine the relationship between scales and anova to compare scale scores with three or more groups of categorical variables. linear regression analysis will be used to examine the effects of sas-sv scores and sociodemographic characteristics on pss-10 and ndi. in addition, the mediating effect of pss-10 on sas-sv and ndi will be examined using a linear regression model. analysis results will be considered significant at p \< 0.05.

Eligibility criteria:
inclusion criteria: * individuals aged between 18 and 49 years, * with a gestational age of 20 weeks or more, * no pregnancy complications, exclusion criteria: * those with musculoskeletal system diseases (such as rheumatoid arthritis, ankylosing spondylitis, scheuermann's disease, ehlers-danlos syndrome, spinal surgeries, nerve root compression, spondylolisthesis comorbidities) * those with diagnosed mental disorders

Keywords: mediation analysis pregnant women smartphone addiction neck disability stress
to quantify the range of main psychosocial factors affecting patients and caregivers in their daily lives

Conditions: Congenital Bleeding Disorder; Haemophilia A; Haemophilia B; Haemophilia A With Inhibitors; Haemophilia B With Inhibitors; Relatives to/Carers of Patients

Summary: this survey is conducted in south america. the purpose is to identify the key psychosocial issues affecting patients with haemophilia.


Eligibility criteria:
inclusion criteria: * men aged 18 years or above with haemophilia a or b (with or without inhibitors) or parents/caregivers of children/adolescents younger than 18 years with haemophilia a or b (with or without inhibitors); only one subject per household will be able to participate * patients currently receiving one of the following treatments: a. replacement factor viii therapy, b. replacement factor ix therapy, c. bypassing agents (recombinant factor viia or apcc) or patients with haemophilia, not receiving any kind of treatment with replacement factor viii or ix or a bypassing agent (as appropriate), but who have had at least one spontaneous haemorrhage into one or more joints within the last 12 months * the participants (patients with haemophilia and parents/caregivers for patients under 18 years old) must be able to complete a paper questionnaire in order to participate in the study * providing informed consent before the start of any study-related activities exclusion criteria: * inability for the patients or parents/caregivers to understand and comply with verbal instructions, unless assisted by a member of the htc (haemophilia treatment center) or by a relative. (no other conditions were established for patients who cannot read or write to be able to participate in this study in addition to the need of help from a member of htc or by a relative.)
the effect of perioperative dexamethasone on postoperative complications after pancreaticoduodenectomy

Conditions: Pancreaticoduodenectomy

Summary: the primary objective of this clinical trial is evaluate the effect of dexamethasone on postoperative complications after pancreaticoduodenectomy.

this is a multicentric, prospective, randomized, double-blind, pragmatic, placebo-control study. patients who are going to receive elective pancreaticoduodenectomy will be randomized to receive 0.2 mg/kg dexamethasone or saline placebo, administered as an intravenous bolus within 5 minutes after induction of anesthesia. the primary outcome is the comprehensive complication index (cci) score within 30 days after the operation, which will be compared between these two groups .

Eligibility criteria:
inclusion criteria: 1. adult patients ≥18 years of age; 2. an indication for elective pd surgery; 3. patients understand the nature of this trial and are willing to comply; 4. patients are able to provide written informed consent; exclusion criteria: 1. current or recent (within preceding 1 month) systemic use of glucocorticoids; 2. distant metastases including peritoneal carcinomatosis, liver metastases, distant lymph node metastases, and involvement of other organs; 3. patients may undergo left, central, or total pancreatectomy other than pd; 4. palliative surgery； 5. patients with high operative risk, as defined by the american society of anesthesiologists (asa), with a score ≥ 4; 6. synchronous malignancy in other organs or second cancer requiring resection during the same procedure; 7. pregnant and lactating women.

Keywords: pancreaticoduodenectomy dexamethasone postoperative complications double-blind pragmatic superiority trial
non-interventional study to investigate the short and long term real-life safety, effectiveness, and adherence of velphoro® in patients with hyperphosphataemia undergoing haemodialysis (hd) or peritoneal dialysis (pd)

Conditions: Hyperphosphatemia

Summary: an oral highly potent p binder velphoro is a mixture of polynuclear iron(iii) oxyhydroxide, sucrose, and starches. it was well tolerated in the clinical development program. the approved indication in the european union (eu) is to control serums phosphorus (sp) levels in adult ckd (chronic kidney disease) patients on hd (haemodialysis) or pd (peritoneal dialysis). it is of major interest to observe the drug in daily use outside of controlled trial settings. the marketing authorisation holder wishes to obtain further systematic data within a non-interventional study to investigate short and long-term safety. effectiveness and treatment adherence during real-life use will be evaluated.


Eligibility criteria:
inclusion criteria: * age ≥18 years * signed informed consent * indication for velphoro treatment in accordance with the smpc * prevalent dialysis patients with a dialysis vintage of at least 6 months (hd or pd) * treatment-naïve or pre-treated with anti-hyperphosphataemic therapy exclusion criteria: * prior participation in this nis (non-interventional study) * parallel participation in an interventional study * enrolment in a prior clinical trial with velphoro
long-term effectiveness of a recombinant hepatitis e vaccine

Conditions: Hepatitis E

Summary: this test-negative study is designed to evaluate the long-term effectiveness of hepatitis e vaccine (hecolin®) and to explore the prevalence of rat hepatitis e in dongtai city.

in this negative test study, residual clinical serum will be collected from 13 hospitals in dongtai, if it was from patients born between 1941-1991 from 11 towns in dongtai, who tested positive for alt levels higher than 2.5 times the upper limit of normal (uln). detection of hev igm, igg, antigen, rna will be performed to diagnose hepatitis e (he) in each individual. in addition, he vaccination history will be collect. all the information above will be used to evaluate the long-term effectiveness of he vaccine. based on the study design, virological and serological detection (igm, igg, antigen, and rna) of hepatitis e virus species c (hev-c) will be performed to analyze the prevalence of rat hepatitis e infection in dongtai.

Eligibility criteria:
inclusion criteria: 1. from 11 townships（anfeng、fuan、tangyang、hougang、liangduo、qingdong、shiyan、shenzao、wulie、xuhe、xinjie） 2. alt ≥ 2.5 uln 3. born between 1941 and 1991

Keywords: hepatitis e test-negative design effectiveness vaccine rat hepatitis e virus infection
endoscopic radiofrequency ablation of celiac ganglion for pain management and improvement of quality of life in patients with unresectable pancreatic cancer

Conditions: Pancreatic Cancer

Summary: this study aims to evaluate the eus-rfa in terms of efficacy for pain management and improvement in quality-of-life parameters for patients with advanced inoperable pancreatic cancer. the primary objectives of this study are to 1) evaluate the utility of eus-rfa for pain control and improvement in quality-of-life parameters for patients with advanced pancreatic cancer; 2) to measure the reduction of analgesic medications' requirements in patients affected by inoperable pancreatic cancer.


Eligibility criteria:
inclusion criteria: * diagnosis of pancreatic cancer based on clinical, radiological, or pathological assessment; * referred for abdominal and/or back pain due to pancreatic cancer; * no prior history of rfa; * cancer pain unresponsive to the who 3-step analgesic ladder; * willingness to consent to participate in the study. exclusion criteria: * patients who are not willing to give informed consent or agree to participate in the study * surgically resectable pancreatic cancer; * abdominal pain with etiology other than pancreatic malignancy; * evidence of concurrent infection; * patients with irreversible coagulopathy international normalized ratio \>1.5 or platelet count \<50,000/mm3), * patients with a preliminary diagnosis of adenocarcinoma are not possible established with intraprocedural at eus-guided fna.
role of salbutamol and furosemide in ttn

Conditions: Transient Tachypnea of the Newborn

Summary: to see the effects of slabutamol and iv furosemide in the treatment of transient tachypnea of newborn


Eligibility criteria:
inclusion criteria: * all newborn babies with clinically diagnosed ttn exclusion criteria: * babies less than 34 weeks babies with congenital malformations and chd
effects of personalized training at home combining endurance and resistance in patients suffering from marfan syndrome

Conditions: Marfan Syndrome

Summary: marfan syndrome (ms) is an autosomal dominant genetic disorder caused by a mutation in the fibrillin-1 gene (fbn1) encoding the protein fibrillin-1. fibrillin is the main component of microfibrils, elements found in all of the body's tissues, and this pathology is characterized by the multitude of its clinical manifestations. these patients may develop aneurysms in the aortic root and one of the main factors of morbidity in patients with ms is aortic dissection. prevention mainly involves preventive aortic surgery. however, the repercussions are global and can affect the functioning of other tissues such as skeletal muscle tissue, bone tissue, lung tissue and the eyes. the association of skeletal (scoliosis, hyperlaxity), muscular and ocular disorders is clearly associated with an impairment in the quality of life. these disorders are associated with pain and disability which affect professional activity, leisure and family life. physical activity could represent a relevant alternative for these patients. a recent animal study suggests that moderate training is beneficial.

the main objective is to show that the quality of life of patients with marfan syndrome can be improved by personalized training at home. the goal is to be able to offer new non-drug management based on physical activity to these patients. improved quality of life; improvement of muscle strength by a muscle strengthening protocol; improvement of cardiovascular function parameters. regular coaching throughout the study. 1. / assessment of muscular capacities 2. / assessment of cardiovascular and respiratory capacities 3. / response to psychometric questionnaires 4. / participation in a training circuit (training protocol)

Eligibility criteria:
inclusion criteria: * patient with marfan syndrome and followed up at bichat claude bernard hospital, paris. marfan syndrome should be diagnosed according to the ghent nosology revised in 2010 * patient taking protective treatment for the aorta (beta blocker, calcium channel blocker, ace inhibitor, angiotensin ii receptor antagonist). * valid patient, able to return to consultation and carry out functional assessments and personalized physical training at home. * patients operated prophylactically on the ascending aorta may be included at a distance \> 6 months from their surgery. exclusion criteria: * myocardial pathology other than marfan syndrome. * thoracic aorta dissection. * aortic diameter \> 45 millimeters. * uncontrolled high blood pressure at rest (systolic blood pressure \> 140 millimeter of mercury and diastolic blood pressure \> 90 millimeter of mercury) * increase in systolic blood pressure \> 160 millimeter of mercury during exercise. * pregnancy at the time of the study

Keywords: physical training
bioavailability of ubiquinol in huntington disease

Conditions: Huntington Disease

Summary: the death of brain cells in huntington disease (hd) is thought to be associated with a lack of normal cell energy and harmful brain substances called free radicals. coenzyme q10 (coq) is a marketed nutritional supplement that may prove useful in hd because it increases cell energy and combats free radicals. most studies of coq have looked at only one formulation of coq ("ubiquinone") in hd. the purpose of the study is to find out if people that switch from the common formulation of coq ("ubiquinone") to a different formulation ("ubiquinol") have higher levels of coq in their blood after taking the same dose. the investigators also want to find out if this different formulation is tolerable for individuals with hd.


Eligibility criteria:
inclusion criteria: * have manifest huntington disease * be 18 years of age or older * be taking an oxidized formulation of coq for at least 30 days prior to the baseline visit * be on a steady dose of all concomitant medications for at least 30 days prior to the baseline visit exclusion criteria: * have a history of intolerability of sensitivity to coq * have an unstable medical or psychiatric illness * be pregnant or breastfeeding; women of childbearing age must use reliable contraception

Keywords: ubiquinol coenzyme q10 huntington disease
the role of music stimulation in disorders of consciousness state: an fmri study

Conditions: Vegetative State; Minimally Conscious State

Summary: the aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (uws) and minimally conscious state (mcs) by using functional magnetic resonance imaging (fmri).

background: sensory stimulations were used widely to evaluate the preserved cerebral functions for these patients with disorders of consciousness. among these, the most alerting or common stimuli are probably familiar voice and music. objective: the aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (uws) and minimally conscious state (mcs) by using functional magnetic resonance imaging (fmri). methods: eleven severely brain-damaged patients (6 uws and 5 mcs) were assessed by functional magnetic resonance imaging while they were exposed under the condition of their personal music. to examine the prognostic value of these patients, longitudinal behavioral assessments were repeatedly conducted by means of the crs-r after fmri acquisition.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old; * no administration of neuromuscular blockers or sedation within the 24 hours of enrolment; * brain damage with eye opening (indicating wakefulness and rest cycles) exclusion criteria: * coma; * neurodegenerative disease; * psychiatric or neurologic illness; * with intracranial metal or other body metal.

Keywords: disorders of consciousness music stimulation functional magnetic resonance imaging
a two-way crossover study of the effect of food on the pharmacokinetics of pazopanib in cancer patients

Conditions: Carcinoma, Renal Cell

Summary: this is two-part study (part i/part ii). part i is designed to determine the effect of a low and high fat meal on the pharmacokinetics of single dose pazopanib (gw572016). part ii is designed to allow patients continued access to study drug in a multiple dosing regimen. patients who are receiving clinical benefit on that regimen will go into the long term rollover study veg105430 provided they are stable for 8 weeks.


Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed diagnosis of advanced solid tumors that have progressed following treatment with standard agents. patients may have either measurable disease by recist or may be followed by a tumor marker for assessment of disease. * eastern cooperative oncology group performance status of 0 or 1. * adequate bone marrow function: anc greater than or equal to 1,500 mm cubed; platelets count greater than or equal to 100,000 mm cubed; hgb greater than or equal to 9 g per dl * adequate renal function as determined by a creatinine clearance greater than 50ml per min calculated by the cockcroft-gault formula; measured creatinine clearance greater than or equal to 50ml per min by 24-hour urine collection will be acceptable in lieu of a calculated value. * urine creatinine ratio of less than 1 as assessed in a random or spot urine sample. * adequate hepatic function: total bilirubin less than or equal to 1.5 times the upper limit of normal; ast and alt less than or equal to 2.5 times the upper limit of normal. * pt, inr, ptt less than or equal to 1.2 times upper limit of normal. * male or female at least 18 years of age. * a woman is eligible to enter and participate in the study if she is of: non-childbearing potential; childbearing potential, has a negative serum pregnancy test at screening, and agrees to use adequate contraception per protocol. a man with a female partner of childbearing potential is eligible to enter and participate in the study if he uses a barrier method of contraception or abstinence during the study. if sexually active, patients will continue the recommended contraceptive measures for the duration of the treatment and for 28 days following discontinuation of therapy. * predicted life expectancy of at least 12 weeks. * written informed consent. * able to swallow and retain oral medications. exclusion criteria: * patients with certain heart problems or history of bleeding within a month.

Keywords: pazopanib gw786034 advanced cancer metastatic cancer
cesarean wound closure: dermabond versus steri strips

Conditions: Scar

Summary: the purpose of this study is to determine overall patient satisfaction with their cesarean section scar with application of steri-strips vs. dermabond following subcuticular skin closure of pfannenstiel incision


Eligibility criteria:
inclusion criteria: * women age 18-45 who are undergoing planned or unscheduled cesarean section at regional one health * gestational age \> 24 weeks * planned pfannenstiel incision * willing to consent to the study exclusion criteria: * emergency or urgent cesarean section * vertical skin incision * intrapartum intraamniotic infection * diabetes * unwilling to consent to the study