Kornimate/medical-research-clean huggingface dataset:
clinical and biological markers of response to cognitive behavioural therapy for depression

Conditions: Depression

Summary: the purpose of this study is to locate clinical markers (for example, interviews, questionnaires, and computer tasks) and biological markers (for example, physiological, blood-based, or electroencephalography measurements) that predict response to cognitive behavioral therapy for depression.

forty adult outpatients with major depressive disorder or persistent depressive disorder will receive up to 20 sessions of cognitive behavioral therapy for depression over 16 weeks. participants will complete clinical measures (interviews, questionnaires, and computer-based tasks) and biological measures (blood tests, physiological measurements, electroencephalography ) before, during, and after treatment.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of major depressive disorder or persistent depressive disorder according to the diagnostic and statistical manual of mental disorders, fifth edition * must be fluent in english * must be capable to give informed consent exclusion criteria: * lifetime diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder * current alcohol or drug use disorder (except tobacco or caffeine) * current psychotic symptoms * acute suicide risk * psychological treatment for depression initiated during the past three months * pharmacological treatment for depression initiated/changed during the past three months * previous non-response to two or more adequate trials of pharmacotherapy * current significant neurological disorder, head trauma, or unstable medical conditions.

Keywords: major depression major depressive disorder persistent depressive disorder cognitive behavioral therapy biomarkers
posture exercises in parkinson's disease

Conditions: Parkinson

Summary: the research was planned as a quasi-experimental study to investigate the effects of postural exercises on body image and neck and trunk position sense in parkinson's patients. it was decided to conduct the study with parkinson's patients over the age of 50 who applied to the neurology clinic. after the power analysis for the research, it was planned to reach 36 participants. participants' consent to participate in the study will be obtained through the informed volunteer consent form prepared by the researchers. demographic information of participants who consent to participate in the study will be collected. then, the disease levels and severity of the participants will be determined using the modified hoehn yahr staging scale and the unified parkinson's disease assessment scale. subjective visual vertical perception, subjective postural perception and subjective haptic perception evaluations to evaluate the body image of patients; clinometer application and neck and trunk proprioception evaluations will be applied as preliminary tests to evaluate neck and trunk position sense. posture exercises planned by the researchers will be applied to the participants, whose pre-tests are completed, three days a week for eight weeks. preliminary tests performed after eight weeks of exercise will be repeated. all data obtained will be recorded in the participant data record form. differences in changes in tests performed at eight-week intervals will be investigated with appropriate statistical methods.


Eligibility criteria:
inclusion criteria: * being over 50 years old, * being diagnosed with parkinson's disease by a physician, * stage 1-4 according to the modified hoehn-yahr staging scale * having received 24≥ from the mini mental test exclusion criteria: * presence of another accompanying neurological disease, * having significant musculoskeletal system problems, * having any known cognitive problem or having a score of ≤23 on the mini mental test

Keywords: parkinson postural exercises verticality position sense
assessing models of exposure therapy

Conditions: Obsessive-compulsive Disorders and Symptoms

Summary: the objective of this study is to learn how to improve treatment for clients who are working hard in treatment at the mclean hospital obsessive compulsive disorder institute (ocdi), but who are not making the progress that would typically be expected. therefore, the investigators will be comparing the performance of such clients in a treatment as usual (tau)-exposure and response prevention (erp) session with their performance in an acceptance and commitment therapy (act)-focused erp session that follows an act booster session. the investigators hypothesize that clients will perform significantly better in the act-focused erp session than they will in the tau-erp session. more specifically, the investigators hypothesize that clients and an independent rater will report that in the act-focused erp session, clients performed significantly fewer rituals and/or avoidance behaviors, experienced comparable levels of distress, exerted significantly more effort, had significantly less difficulty getting started with the erp, were significantly less influenced by their uncomfortable thoughts/feelings, were significantly more willing to experience discomfort, were significantly more focused on working towards what is important to the client. the investigators also hypothesize that an independent rater will rate clients as significantly more compliant with the act-focused erp session than with the tau-erp session. the investigators also hypothesize that clients will rate the act-focused erp session as significantly more preferable and acceptable than the tau-erp session, and that they will report being significantly more willing to do the act-focused erp session again.


Eligibility criteria:
inclusion criteria: * participants will be adults at least 18 years of age currently enrolled in the residential or day treatment program at the ocdi.
effect of age on prf quality; assessed by evaluating healing outcomes of arp

Conditions: Healing Wound

Summary: this study will examine whether using prf and your age are going to affect the healing and regeneration benefits gained from prf.

platelet-rich fibrin (prf) is commonly used to enhance gum tissue healing and reducing pain after tooth extraction and before placing a dental implant. 44 patients requiring a tooth extraction will be recruited and randomized to receive a collagen plug with or without platelet-rich fibrin.

Eligibility criteria:
inclusion criteria: 1. age range: 20 to 80 years. 2. patients must require tooth extraction (molars) as a result of caries, periodontal disease, tooth fracture or deemed unrestorable. 3. non-infected sockets with intact buccal bone (≥1.5 mm in thickness measured through calipers) 4. patients interested in implant placement following tooth extraction. exclusion criteria: 1. allergies or hypersensitivities to study related medications. 2. hematologic disorders/blood dyscrasias. 3. active infectious diseases of any kind. 4. liver or kidney dysfunction/failure. 5. uncontrolled diabetes (hba1c \> 8). 6. active cancer treatment - such as active chemotherapy or radiation therapy. 7. taking medications that will affect their bone healing (for example, bisphosphonates, long-term nsaids use, steroid). 8. metabolic bone diseases that affect bone healing such as osteoporosis. 9. pregnant or lactating women (self-reported). 10. smoke 10 or more cigarettes per day (self-reported). 11. poor oral hygiene. 12. systemic diseases that compromise the immune system 13. anti-coagulant therapy
efficacy and safety of gemcabene in hypercholesterolemic patients on stable statin therapy

Conditions: Hypercholesterolemia

Summary: the purpose of this study is to evaluate the effect of gemcabene on ldl-c and other lipid parameters in hypercholesterolemic patients on a stable dose of a statin.


Eligibility criteria:
inclusion criteria: * males and females * 18 to 65 years of age * baseline ldl-c ≥ 130 mg/dl (3.4 mmol/l) exclusion criteria: * if female, postmenopausal or surgically menopausal * triglycerides (tg) \>400 mg/dl * creatine phosphokinase (cpk) \>3 × the upper limit of normal (uln) * body mass index (bmi) \>35 kg/m2 * uncontrolled diabetes mellitus (hba1c \>10%) * renal dysfunction (blood urea nitrogen \[bun\] or creatinine \>2 × uln) * hepatic dysfunction (aspartate aminotransferase \[ast\] or alanine aminotransferase \[alt\] \>2 × uln) * myocardial infarction, severe or unstable angina pectoris, coronary angioplasty, coronary artery bypass graft, or any other major cardiovascular event resulting in hospitalization in previous month

Keywords: ldl-c lipid regulator
effect of peep on intraoperative hypothermia

Conditions: Spinal Diseases

Summary: intraoperative hypothermia is associated with many clinical adverse outcomes. many techniques were applied to prevent intraoperative hypothermia, and positive end-expiratory pressure (peep) has been known to blunt intraoperative hypothermia by increasing thermoregulatory vasoconstriction threshold. the investigators assessed the effect of peep on the prevention of intraoperative hypothermia during spine surgery in prone position.

it is well known that intraoperative hypothermia is associated with postoperative adverse clinical outcomes in various study populations. intraoperative hypothermia has various adverse effects including impaired drug clearance, cold diuresis and hypovolemia, immunosuppression with increased infection risk, electrolyte disorders, coagulopathy with impaired platelet function, negative nitrogen balance, shivering, insulin resistance, and myocardial events. numerous methods have been introduced to prevent intraoperative hypothermia, such as warming of infusion fluid, forced-air warming, heat-pads, heated water mattress, and heated humidifiers. however, in patients undergoing lumbar spine surgery in the prone position, these methods to prevent intraoperative hypothermia may partially effective because these methods, in clinical practice, have a significant limitation in their application. positive end-expiratory pressure (peep) reduces the venous return by increasing intrathoracic pressure. this causes carotid unloading, which leads to a secondary peripheral vasoconstriction by increasing thermoregulatory vasoconstriction threshold and blunts intraoperative hypothermia. previous studies demonstrated that intraoperative peep significantly attenuated the extent of intraoperative hypothermia in patients undergoing tympanoplasty. however, the beneficial effect of peep on thermoregulation is not investigated in patients with the prone position for spinal surgery. the investigators hypothesized that peep can reduce the extent of intraoperative hypothermia via thermoregulatory modulation. in this study, the investigators investigated the effect of peep on intraoperative core body temperature and the incidence of intraoperative hypothermia in patients undergoing spinal surgery

Eligibility criteria:
inclusion criteria: * patients who were scheduled for elective spine surgery requiring more than 3 hours exclusion criteria: * patients who do not agree to the study * patients with or american society of anesthesiologists (asa) physical status class 3 or more * patients with thyroid disease, peripheral vascular diseases, uncontrolled diabetes or hypertension * patients with morbid obesity (bmi \>35 kg/m2) * patients with clinically severe pulmonary disease * patients undergoing simultaneous anterior and posterior lumbar fusion surgery were also excluded. * patients with taking non-steroidal anti-inflammatory drug within two weeks * patients with preoperative fever or hypothermia * patients with intraoperative intentional hypothermia for neuroprotection
single versus long-term intravesical instillation chemotherapy for recurrence after nephroureterectomy for upper tract urothelial carcinoma

Conditions: Intravesical Instillation

Summary: up to 30-40% of the patients may develop bladder recurrance after radical nephroureterectomy for primary upper tract urothelial carcinoma. bladder tumor needs transurethral resection, which is associated with costs of treatment and potential poor prognosis. although several randomized controlled trial have shown that prophylactic intravesical chemotherapy could prevent bladder tumor recurrence, the optimal schedule and duration of treatment are unkown. the investigators want to determine the efficiacy of single instillation versus long-term intravesical instillation of pirarubicin for bladder recurrence after radical nephrouretectomy for primary upper tract urothelial carcinoma.


Eligibility criteria:
inclusion criteria: * clinically diagnosed with upper tract urothelial carcinoma * have no distant metastasis * have an ecog 0 to 2 * expected to receive radical nephroureterectomy exclusion criteria: * a prior history of bladder or synchronous bladder cancer * administration of neoadjuvant chemotherapy * the presence of severe complications * deny to receive cytoscopy * patients with advanced stage (t4) * patients with contralateral utucs

Keywords: urothelial cancer bladder cancer nephroureterectomy
treatment of malignant glaucoma by anterior vitrectomy from two different approaches

Conditions: Glaucoma Secondary

Summary: to compare the surgical outcomes of treating phacoemulsification with intraocular lens implantation combined with goniosynechialysis (phaco-iol-gsl) associated malignant glaucoma (mg), using different incision sites in anterior vitrectomy combined with hyaloidotomy, zonulectomy, and iridectomy (vhzi).


Eligibility criteria:
inclusion criteria: * mg was diagnosed based on the presence of a central and peripheral shallow anterior chamber with normal or elevated intraocular pressure (iop). exclusion criteria: * the diagnosis was made only after confirming the absence of choroidal detachment or hemorrhage and posterior segment mass lesion, using b-scan ultrasonography or ophthalmoscopy
the effect of a single intravitreal anti-vegf therapy on optic nerve head perfusion

Conditions: Macular Degeneration; Regional Blood Flow; Vascular Endothelial Growth Factor

Summary: age related macula degeneration is one of the most common sight threatening diseases of the elderly. the so called wet form of amd is caused by choroidal neovascularisation (cnv) of pathological vessels, which lead to leakage, bleeding and macular edema. several lines of evidence suggest that vascular endothelial growth factor (vegf) plays a key role in the induction cnv. recent evidence indicates that overexpression of vegf in the retinal pigment epithelium may lead to the development of cnv in experimental models, and intravitreal injection of a vegf blocker prevents the development of experimental cnv. this hypothesis is also supported by the promising effects of anti-vegf treatment in patients with choroidal neovascularisation. the substances currently in clinical use include ranibizumab (lucentis®), bevacizumab (avastin®) and pegaptanib (macugen®). however, from a physiological point of view, vegf also serves as a survival factor for existing vessels and for neuronal cells. moreover, it has been reported that vegf induces vasodilatation, most probably by an increased production of nitric oxide. accordingly one may hypothesize that anti-vegf treatment is associated with ocular vasoconstriction with unknown long term results. thus, in the current study, the investigators set out to investigate whether the ocular perfusion is affected by a single intravitreal anti-vegf.


Eligibility criteria:
inclusion criteria: * 40 subjects ≥ 50 years of age * subjects with all angiographic subtypes of neovascular wet amd, already scheduled for intravitreal anti-vegf therapy in one eye * good central or eccentric fixation exclusion criteria: * history or previous anti-vegf therapy * history or previous intravitreal injection with any drug * intraocular pressure ≥ 25 * glaucoma * history or presence of thromboembolic events * diabetes mellitus * blood donation during the previous 3 weeks * ametropy ≥ 6 dpt

Keywords: age-related macular degeneration anti-vegf
cognitive functions in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: approximately 65% of multiple sclerosis (ms) patients appear to have problems in their cognitive function. long-term memory is one of the most frequently affected functions in ms patients. many factors play a role in the deterioration of cognitive functions because of many symptoms of ms. the aim of this study is to investigate the relationship of cognitive function with physical factors such as balance, functional exercise capacity and personal factors such as fatigue level, mood, sleep quality in patients with ms.

patients with ms between 0-5,5 score according to the extended disability status scale (edss) and healthy individuals of similar age and sex to patients will be included in the study. the cognitive function, balance, functional exercise capacity, fatigue, mood, sleep quality will be evaluated once. investigators will use descriptive statistics and t-tests to compare variables between groups. investigators will examine the correlations between variables using pearson bivariate correlations. the significance level is set at p\<0,05.

Eligibility criteria:
inclusion criteria: * participants who 18-65 years of age * ms patients who are ambulatory (expanded disability status scale score ≤ 5,5 ) in a stable phase of the disease, without relapses in the last 3 month. exclusion criteria: * participants who have orthopedic, vision, hearing, or perception problems

Keywords: multiple sclerosis balance cognition functional exercise capacity fatigue sleep quality
using bupivacaine locally in the mastectomy drains to control postoperative pain

Conditions: Pain, Postoperative; Breast Cancer

Summary: in this study we are investigating the role of instillation of bupivacaine through surgical drains at the end of mastectomy surgeries in controlling post operative pain and decreasing their pain killers requirement in the early postoperative period

patients were enrolled into 2 groups. in one group the wound was installed by 40ml of 0.25% bupivacaine through axillary and chest wall drains (20ml in each drain). then, the drains were clamped for 20 minutes. in the other group the wound was installed by 40ml of 0.9% normal saline through axillary and chest wall drains (20ml in each drain). then, the drains were clamped for 20 minutes. (placebo group) patients and health care providers were blinded as regard the study group patients enrolled in. visual analog pain scale which is a score for detection of how much the patient is annoyed from the pain- was assessed two and four hours post-operative then every four hours thereafter.

Eligibility criteria:
inclusion criteria: female patients with unilateral breast cancer candidates for total mastectomy and axillary dissection exclusion criteria: 1. male patients 2. bilateral breast cancer. 3. patients with a history of a long duration of nsaid intake or other painkillers, drug abuse 4. patients with chest wall pain like tietze syndrome, history of angina pectoris or recent hzv infection. 5. patients with known psychological or mental problems. 6. patients who were not exposed to axillary dissection

Keywords: bupivacaine post-mastectomy acute pain wound instillation
effect of lumbrical stretching on carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: symptoms of cts occur when any condition decreases the size of the carpal canal or increases the volume of the structures within the carpal canal, compressing the median nerve. one cause of the symptoms of cts is the incursion of the lumbrical muscles of the hand into the carpal canal. individuals with cts tend to have tight lumbrical muscles which increase this incursion, thereby increasing cts symptoms. an intervention designed to reduce the incursion of the lumbrical muscles should have an effect on the symptoms of cts. the purpose of this study is to systematically examine the effect of an intensive lumbrical muscle intervention, splinting to prevent lumbrical muscle incursion and lumbrical muscle exercises, on the symptoms of cts. this project will be a randomized clinical trial to evaluate the effectiveness of a home program targeting the lumbrical muscles. one hundred and twenty subjects will be assigned to one of 4 groups: group 1 will receive a home program of lumbrical muscle stretches combined with a lumbrical positioning splint; group 2 will receive a home program of lumbrical muscle stretches combined with a night wrist cock-up splint; group 3 will receive a home program of general stretches combined with a lumbrical positioning splint; and group 4 will receive a home program of general stretches combined with a night wrist cock-up splint. after 1 month, 3 months, and 6 months the groups will be compared to determine if there is a significant reduction in symptoms between the groups.


Eligibility criteria:
inclusion criteria: * at least 18 yo * clinical symptoms of carpal tunnel syndrome (cts) * positive tinel's, phalen's, or durkin's test * absence of thenar atrophy * 2 pt discrimination of 5mm or less exclusion criteria: * persons needing immediate cts surgery * pregnancy * compressive neuropathy in the ipsilateral arm * diabetes * prior cts release * non-english speaking

Keywords: carpal tunnel syndrome splint hand exercises
reassessement after hospitalization for sars-cov-2 disorder

Conditions: Sars-CoV2

Summary: currently, the sequelae and short-term medical and psychological impact of the sars-cov-2 infection ("covid-19") remain poorly described. the clinical and functional sequelae that may persist after acute sars-cov-2 ("covid-19") infection are essential to explore, in order to ensure the best possible follow-up of patients after discharge from hospital.

since sars-cov-2 ("covid-19") is a newly defined infection, its sequelae and short-term medical and psychological impact remain poorly described.the clinical and functional sequelae that may persist after acute sars-cov-2 ("covid-19") infection are essential to explore, in order to ensure the best possible follow-up of patients after discharge from hospital. indeed, some patients may develop chronic respiratory failure, pulmonary fibrosis, or other comorbidities including cardiovascular or metabolic diseases. the psychological impact is also essential to assess. the sequelae and comorbidities of patients could also vary depending on the severity of the initial acute involvement. investigators propose to explore the sequelae of patients who have been hospitalized for acute sars-cov-2 infection, between 3 to 6 months after discharge from hospital, by characterizing the incidence of chronic respiratory failure and fibrosis, as well as of various comorbidities such as cardiovascular, metabolic, and psychological diseases.

Eligibility criteria:
inclusion criteria: * patient who was hospitalized within 3 to 6 months for a sars-cov infection exclusion criteria: * absence of signed informed consent * pregnancy or breastfeeding * patient under guardianship or curatorship

Keywords: comorbidities sars-cov2 sequelae patient outcome assessment covid19 quality of life
effect of sitagliptin on progression of coronary intermediate lesion

Conditions: Atherosclerosis; Type 2 Diabetes Mellitus

Summary: this study was to investigate the effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on progression of coronary intermediate lesion.


Eligibility criteria:
inclusion criteria: * patients \> 18, \< 80 years old, with type 2 diabetes mellitus and angiographically proven coronary intermediate lesion. exclusion criteria: * allergy or hypersensitivity to any of the drug's components. * severe liver failure, moderate or severe kidney failure * malignant disease. * active infectious disease. * pregnancy or breastfeeding.