Kornimate/medical-research-clean huggingface dataset:
high intensity body-weight circuit training feasibility and efficacy for in middle aged persons with type 2 diabetes

Conditions: Type2diabetes

Summary: this research study proposes to quantify the efficacy of the novel high intensity body-weight circuit (hibc) training intervention on metabolic profile, body composition, and health related fitness exercise in middle aged persons with type-2 diabetes (t2dm). this research project is extremely relevant to public health, in that prevalence of t2dm continues to rise on a national and global scale, placing a heavy economic cost on both the healthcare industry and the individual patient in an age-dependent fashion. results of this study may provide an effective and appealing alternative exercise intervention for cardiometabolic disease management in adults with t2dm, and have significant clinical and public health applications.


Eligibility criteria:
inclusion criteria: * recent diagnosed of type 2 diabetes (t2dm) (within a year) \* hba1c of 6% or higher * non-insulin dependent * no medicinal treatment * not currently undergoing a physical activity program in the last six months * received written medical clearance from overseeing physician exclusion criteria: * those who have undergone any revascularization procedure * diagnosed with or symptomatic of any renal, pulmonary, or cardiovascular disease (cvd) * diagnosed cognitive dysfunction * current smoker

Keywords: exercise
the effect of combined use of anti-fibrotic agent with platelet rich plasma on skeletal muscle healing after acute injuries

Conditions: PRP; Losartan; Muscle Injury; Sport Injury

Summary: the aim of this comparative study is to determine whether or not losartan with its anti-fibrotic action has an added effect when administrated with platelet rich plasma injection on skeletal muscle healing and on decreasing the fibrous scar after muscle injuries in comparison with the sole administration of platelet rich plasma.


Eligibility criteria:
inclusion criteria: * adult age. (18 - 40 year old). * clinically diagnosed acute skeletal muscle injury with maximum 3 days duration and ultrasonographically confirmed grade ii according to woodhouse et al. * understanding the study and accepting the participation exclusion criteria: * any connective tissue disease (e.g. rheumatoid arthritis, systemic lupus erythematous, etc.) * hypertension or hypotension * diabetes mellitus * any cardiac or pulmonary disease * nsaids use in less than a week prior to the beginning of the study. * muscle injuries requiring surgical interference. * no detectable injury ultrasonographically. * anemia * thrombocytopenia or any platelet disorder. * pregnancy or lactation. * local infection
phase ii clinical trial of npb-01 in patients with anti-aquaporin 4 antibody positive neuromyelitis optica spectrum disorder not provided adequate effect of therapy to steroids plus therapy.

Conditions: Neuromyelitis Optica Spectrum Disorder

Summary: patients diagnosed with anti-aquaporin 4 antibody positive neuromyelitis optica spectrum disorder were confirmed based on diagnostic criteria. patients who meet all inclusion criteria and do not conflict with the exclusion criteria will receive steroid plus therapy （1g/day for five consecutive days）. subsequently, patients who not provided adequate effect of therapy to steroids plus therapy will receive npb-01 (intravenous immunoglobulin) 400mg/kg/day for five consecutive days. patients evaluated quantification of nerve and spinal cord impairment （qosi） and the expanded disability status scale （edss）/ functional systems （fs） and anti-aquaporin 4 antibody et al. as a safety endpoint, the safety of npb-01 will be investigated the occurrence of adverse events by one year after the start of the study treatment.


Eligibility criteria:
inclusion criteria: 1. patients who become positive for anti-aquaporin 4 antibody or have becomed. 2. patients who have developed myelitis. 3. patients who run beyond greater than 30 days at least from last time in relapse. 4. patients who new neurological symptom or worsening neurological symptom or flared neurological symptom have sustained 24 hours at least not associated fever or infection. 5. patients who have an acute exacerbation at informed consent. 6. patients who need steroid plus therapy（1g/day for five consecutive days）. 7. patients who can start steroid plus therapy within 3 days after informed consent. 8. patients who be inadequate to effect to steroid plus therapy. 9. patients with greater than or equal to twenty years old at informed consent. exclusion criteria: 1. patients who have developed optic neuritis. 2. patients treated with intravenous immunoglobulin within 14 days before informed consent. 3. patients with malignancy at informed consent. 4. patients with history of shock or hypersensitivity for npb-01. 5. patients with iga deficiency. 6. patients with impaired liver function. 7. patients with impaired renal function. 8. patients with cerebro- or cardiovascular disorders. 9. patients with high risk of thromboembolism. 10. patients with hemolytic/hemorrhagic anemia. 11. patients with decreased cardiac function. 12. patients with decreased platelet.

Keywords: ivig in neuromyelitis optica spectrum disorder patients with neuromyelitis optica spectrum disorder
pretreatment identification of duloxetine success in neuropathic pain patients

Conditions: Diabetes; Painful Neuropathy

Summary: the purpose of this study is to identify, prior to prescribing, which neuropathic pain patients will benefit from duloxetine more specific the investigators aims are to: * verify whether presence of chronic pain alters the pain modulation mechanisms, such as dnic (diffuse noxious inhibitory control) and ts (temporal summation). * investigate whether anti-neuropathic medications such as duloxetine indeed change the pain modulation profile, and whether this profile change is associated with a reduction of clinical pain.

there is no accepted practice for selecting among recommended medications for the individual neuropathic pain patient. guidelines published to date provided the evidence for their efficacy, however, data is not available on how to choose the right medication for the right patient in order to avoid long 'trial and error's. we hypothesize that medications affecting specific process of pain modulation will be more efficacious in patients expressing dysfunction of that specific process. therefore, medications that enhance descending inhibition such as ssnri will be more efficacious in patients with less-efficient pain inhibition. the latter is assessed by the conditioned pain modulation (cpm) paradigm. accordingly, the aim of this study is to examine this hypothesis in painful diabetic neuropathy patients, using duloxetine, an ssnri agent assumed to augment descending pain inhibition by reuptake inhibition of noradrenalin and serotonin in the spinal cord dorsal horn synapses. we expect to find better effect of duloxetine in those patients whose pain inhibition capability is less efficient, as expressed by their baseline cpm. further, we aim to evaluate whether pro-nocieptive pattern of pain modulation indeed reverses in response to treatment. this will be explored by comparing the cpm responses before and after treatment, and by correlating pain alleviation with the possible changes in cpm.

Eligibility criteria:
inclusion criteria: * patients diagnosed as having painful diabetic neuropathy. * pain is experienced for more than 3 months. * pain severity is ≥ 4 on a 0-10 scale (last month average). exclusion criteria: * patient already receiving duloxetine or another snri/ssri. * known hypersensitivity to duloxetine or any of the inactive ingredients. * treatment with a monoamine oxidase inhibitor (maoi) within 14 days of randomization or potential need to use an maoi during the study or within 5 days of discontinuation of study drug. * uncontrolled narrow-angle glaucoma * because of the risk of serious ventricular arrhythmias and sudden death potentially associated with elevated plasma levels of thioridazine (mellaril), cymbalta and thioridazine should not be co-administered * inability to perform psychophysical testing, due to language or perceptual barriers.
different lung ultrasound imaging protocols in covid-19 pneumonia

Conditions: Lung Ultrasound; Pneumonia; Covid19

Summary: lung ultrasonography (lus) is also used in covid 19 pneumonia for diagnostic and follow-up purposes.it has been demonstrated in different studies that it can be used for pathologies in pleural and lung tissue. lus was applied by different researchers by dividing the lungs into 12 and 14 regions and the results were shared.

in our study, we aimed to determine the correlation between lung findings of covid 19 pneumonia and thoracic tomography with the results of lus applied to different numbers (12 versus 14) of areas.

Eligibility criteria:
inclusion criteria: * 18 and 85 years old * hospitalized in intensive care unit * pcr (polymerase chain reaction) tested * thoracic ct applied exclusion criteria: * previous lung operation * thoracic wall disorder * interstitial lung disease * patients who did not consent to participate in the study
cognitive behavioral suicide prevention for psychosis: aim 2

Conditions: Suicide; Psychosis

Summary: investigators will evaluate the feasibility and preliminary effectiveness of modified cognitive behavioral suicide prevention for psychosis (cbspp) in comparison to services-as-usual (sau) in a randomized controlled trial. investigators will recruit adult clients receiving services at a community mental health (cmh) setting who have a schizophrenia spectrum disorder and recent suicidal thoughts or behaviors within 3 months of screening (n=60). client participants will be screened, enrolled and randomized to the cbspp or sau group. a 4-wave design will include quantitative assessments at baseline (t1), 1-month after baseline (t2), 3-months after baseline (t3), and 5-months after baseline (t4) with in-depth qualitative interviews at t3 for a random sample of adults in the cbspp group (n=10). providers (n=12) will be trained to deliver cbspp and be assessed from t1-t3 to evaluate the implementation process, including in-depth qualitative interviews at t3.


Eligibility criteria:
inclusion criteria: * schizophrenia spectrum disorder * suicide ideation and/or attempt within 3 months of screening * ability to speak and read in english * 18 to 65 years of age exclusion criteria: * requiring emergency care (e.g. imminent plan to harm self) as determined by trained research staff administering the columbia-suicide severity rating scale (c-ssrs) * inappropriate for behavioral treatment according to own judgment in consultation with a treating clinician cmh * impaired capacity (cognitive capacity)

Keywords: suicide prevention cognitive behavioral therapy community mental health
the effect of listening to music during cpap on the agitation levels and compliance.

Conditions: COVID-19; COVID-19 Acute Respiratory Distress Syndrome

Summary: aim: this study was conducted to determine the effect of listening to music during cpap on the agitation levels of intensive care patients who underwent cpap due to covid-19 and their compliance with the treatment. study design: this study is a prospective, randomized, controlled clinical trial. seventy-six intensive care patients with covid-19 were included in this study and assigned to the music and control groups via the block randomization method. the study was completed with 70 patients. in this study, the patients and outcome assessors were not blinded. the richmond agitation and sedation scale (rass) level, respiratory rate, oxygen saturation (spo2), and mask air leakage amount were the result criteria. results: the mean rass score of the patients in the intervention group was 2.14±0.69 before cpap, 1.63±064 at the 1st minute, 0.89±0.58 at the 15th minute, and 0.74±0.61 at the 30th minute. the mean rass score of the patients in the control group was 2.06±0.53 before cpap, 1.80±0.58 at the 1st minute, 1.43±0.60 at the 15th minute, and 1.46±0.61 at the 30th minute of cpap. there was a statistically significant difference between the groups at the 15th and 30th minutes (t=-3.81, p \< .001; t=-4.89, p \< .001, respectively).


Eligibility criteria:
inclusion criteria: 1. over 18 years old 2. received cpap treatment for 1 day in the intensive care unit, 3. not hearing impaired, 4. no sedation treatment 5. not diagnosed with a psychiatric illness, 6. hemodynamically stable, 7. not taking drugs (such as digoxin, adrenaline, dopamine) that affect blood pressure and pulse rate 8. patients with a glasgow coma scale score of 14 and above will be accepted. exclusion criteria: 1. the patient's desire to leave the study 2. be under the age of 18 3. putting the patient on mechanical ventilation 4. have a hearing impairment 5. receiving sedation therapy 6. diagnosed with psychiatric illness 7. using drugs (such as digoxin, adrenaline, dopamine) that affect blood pressure and pulse rate 8. patients with a glasgow coma scale score below 14 will not be included in the study.

Keywords: covid-19 cpap adapt listen to music
intervening early: key adolescent outcomes

Conditions: Depressive Symptoms; Conduct Disorder; Anxiety Disorders

Summary: this study follows children into adolescence who were first randomized to intervention condition in infancy.

parents serve as co-regulators for their young children, helping them regulate behaviors, emotions, and physiology and supporting the development of healthy brain circuitry. neglecting parents often fail to serve as co-regulators, which has implications for young children's self-regulatory capabilities and brain development. as children become older, these difficulties with self-regulation may become more pronounced. adolescence represents a period of particular vulnerability for the emergence of mental health problems because of increasing demands for regulation of emotions and behaviors, coupled with on-going development of neural circuits that support emotional and behavioral regulation. the attachment and biobehavioral catch-up (abc) intervention was designed to help parents learn to interact in responsive and sensitive ways, with the expectation that children would show enhanced ability to regulate behavior, emotions, and physiology. the efficacy of the abc intervention among parents involved with child protective services (cps) was assessed. parents were randomized to abc or to a control intervention. children were followed at t1 (ages 1-4) and t2 (ages 8-10). at t1, more of the children in the abc group developed secure and organized attachments than children in the def group, and children in abc showed more normative production of cortisol, less expression of negative emotions, and poorer inhibitory control than children in def. abc parents were more sensitive and showed more optimal neural activity than def parents. at t2, abc children showed greater prefrontal cortex activation in response to threat than def children, suggesting better regulation to threat at the level of brain activation. also at t2, children in the abc group reported more secure relationships with parents, and showed more normative cortisol production and more optimal autonomic nervous system functioning than def children. in adolescence, the abc intervention is expected to result in enhanced brain circuitry and more optimal functioning across domains as assessed at multiple levels of analysis relative to the control intervention. in the proposed study, behavioral and neurobiological development among 13-, 14- and 15-year-old adolescents whose parents were referred by cps to a randomized controlled trial in infancy (n=120), and among low-risk adolescents followed since middle childhood (n=80) will be assessed.

Eligibility criteria:
inclusion criteria: * must have been included in middle childhood data collection exclusion criteria: * none
pet/mr imaging in patients with cardiac sarcoidosis

Conditions: Cardiac Sarcoidosis

Summary: pet scanning (positron emission tomography) is a well-established technique used to identify areas of interest within the body. it involves injecting a radioactive tracer which highlights abnormal areas. it has recently been combined with ct (computed tomography) and mri (magnetic resonance imaging) scanning to more accurately identify abnormalities within the heart. cardiac sarcoidosis, a condition which causes scarring and inflammation within the heart muscle, is of particular interest. the study makes use of hybrid pet/mr scanning using a designated scanner which enables pet scanning combined with mri scanning. this will allow imaging of abnormal areas within the heart in this condition alongside treatment regimens in a way which hasn't been done before. if successful, this imaging method will play a key role in diagnosing, quantifying and monitoring these conditions. all participants will undergo pet scanning, where a radioactive tracer is injected into a vein before the scan. the radioactive substance only lasts for a short time and is safe, passed out of the body in urine. the scan will be performed twice; once before treatment and once after treatment has been established. a cohort of healthy volunteers will undergo scanning in exactly the same way to enable us to compare the results with hearts of people who don't have cardiac sarcoidosis.


Eligibility criteria:
inclusion criteria: cardiac sarcoidosis patients: * aged over 40 years * completion of informed consent * established diagnosis of cardiac sarcoidosis * established diagnosis as per hrs recommended diagnostic criteria healthy volunteers: * aged over 40 * completion of informed consent exclusion criteria: * all participants: * inability or unwilling to give informed consent * women who are pregnant, breastfeeding or of child-bearing potential (women who have experienced menarche, are pre-menopausal and have not been sterilised) will not be enrolled into the trial. * major intercurrent illness with life-expectancy \<2 years. * renal dysfunction (egfr less than or equal to 30ml/min/1.73m2) * adverse reaction or hypersensitivity to 18f-fdg pet tracer * nyha class iv heart failure * patients with atrial fibrillation and poor rate control * contraindications to mri scanning * previous history of contrast allergy of adverse reactions (gadolinium-containing agents)
hyperpolarized 129xe mri lung health cohort

Conditions: Healthy

Summary: a subset of young adults participating in the american lung association (ala) lung health cohort (lhc) will be imaged using hyperpolarized 129xe mri to assess lung structure and function. images will be used to improve the understanding of lung health and early lung abnormalities that may lead to chronic lung disease.


Eligibility criteria:
inclusion criteria: * is enrolled in the american lung association lung health cohort study. * has completed ct imaging for the lhc study within 2 years of the scheduled xe-mri date. exclusion criteria: * pacemaker, internal defibrillator or other implanted electronic devices or any standard mri contraindications (e.g., claustrophobia, \> 140 cm shoulder circumference, dependent on weight distribution). * is pregnant or breastfeeding * oxygen saturation (spo2) \<88% on room air or with supplemental oxygen.
influence of an intervention on diet, physical exercise and mindfulness in the quality of life of survivors with breast cancer

Conditions: Breast Cancer; Nutrition Related Cancer; Physical Activity; Mindfulness

Summary: abstract background: breast cancer (bc) is one of the leading causes of death among women around the world. integrative oncology, together with conventional medical treatment, has proven to be an important support for the control of cancer symptoms, improvement of quality of life, and contribution to the overall patient health, providing an integrated patient care both physically and emotionally. methods: 75 stage ii-iii breast cancer survivors were randomized (according to age, tumor stage and receptor status) into 2 groups: intervention and control. within the intervention group (ig) a diet, exercise and mindfulness intervention was performed, while the control group (cg) did not receive any sort of treatment, during 6 months. passed (at the beginning and end of the research) questionnaires concerning general health, quality of life (eortc qlq-c30 and br23), and diet (mediterranean diet adherence test and 24-h-recall) and a blood and urine sample was collected to analyze general biochemical variables. results:


Eligibility criteria:
inclusion criteria: * patients between 18 and 70 years of age * breast cancer iia-iib operable in follow-up * seen in the oncology service of the virgen de las nieves hospital in granada * residents in the city or metropolitan area of granada * had completed, in the 12 months prior to its inclusion, treatment with surgery, radiotherapy and / or systemic chemotherapy treatment (including biological treatment). exclusion criteria: * those who presented some physical or psychic limitation that prevented the intervention from being carried out were excluded from the study.

Keywords: breast cancer survival mediterranean diet physical activity mindfulness
progesterone-primed ovarian simulation in controlled-ovarian simulation of infertile pcos patients

Conditions: PCOS

Summary: the study evaluated the safety and efficacy of the progesterone-primed ovarian stimulation (ppos) coupled with gonadotropin (fsh) for infertile women with polycystic ovary syndrome (pcos) who were assigned for icsi and frozen blastocyst transfer. 200 infertile women were divided randomly into group c, which received cetrorelix injection (0.25 mg daily) on day-6, and group s, which received oral dydrogesterone (20 mg/day) on day-2 of the menstrual cycle till the trigger day. all patients received an fsh injection of 225 iu daily from day-2 till triggering day. icsi was performed and day-5 blastocysts underwent vitrification ultra-rapid cryopreservation till being transferred. outcomes included the ability of ppos to suppress the premature luteinizing hormone (lh) surge and prevent the development of ovarian hyperstimulation syndrome (ohss), the incidence of profound lh suppression, the number of retrieved m2 oocyte and fertilization, chemical and clinical pregnancy rates, and the miscarriage rate.


Eligibility criteria:
inclusion criteria: * infertile pcos women; * aged 20-35 years; * had bmi \<35 kg/m2. exclusion criteria: * women who were younger than 20 or older than 35 years, * obese of grade ii or iii, * had poor or, other causes of infertility, * had previous attempts of ivf, had a history of repeated pregnancy loss.