Kornimate/medical-research-clean huggingface dataset:
a mindfulness-based intervention for treatment of anxiety in icd (implantable cardioverter defibrillator) patients

Conditions: Anxiety Disorder in Conditions Classified Elsewhere

Summary: the purpose of this study is to evaluate the feasibility and preliminary efficacy of a mindfulness-based behavioral intervention combining breathing and other relaxation exercises on symptoms of anxiety in patients undergoing the implantation of an implantable cardioverter defibrillator. this study will pilot test the feasibility and preliminary efficacy of a mindfulness-based intervention intended to improve mindfulness and anxiety levels in icd (implantable cardioverter defibrillators) patients. a randomized controlled study design will be used, in which an 8 session phone-delivered mindfulness intervention will be compared to a usual care condition among consecutive candidates for icd procedures. the study will be conducted at the electrophysiology (eps) unit at the umass memorial medical center. assessments will be performed at baseline and at the end of the intervention (9 weeks after enrollment).

the specific aims of this pilot study are: primary aim: to determine the feasibility of a randomized clinical trial of a phone-administered, mindfulness-based training program, as measured by recruitment and retention rates, treatment adherence and fidelity. secondary aims: 1. to obtain preliminary estimates of the effect of a phone delivered mindfulness-based intervention on mindfulness levels, measured as the difference between baseline and post-intervention five factors of mindfulness scores (ffm) in the intervention and in the control group at the end of the intervention. hypothesis: mindfulness levels will improve in the intervention group compared to the control group. 2. to obtain preliminary estimates of the effect of a phone delivered, mindfulness-based intervention on anxiety, measured as the difference between baseline and post-intervention hospital anxiety and depression (had) anxiety scores in the intervention and in the control group at the end of the intervention. hypothesis: anxiety levels will be reduced in the intervention group, compared to the control group. 3. to collect preliminary data about the number of arrhythmic episodes/administered shocks during the intervention period. hypothesis: the proportion of patients experiencing arrhythmic events/shocks will decrease in the intervention vs. the control group.

Eligibility criteria:
inclusion criteria: 1. age ≥ 21 2. icd procedure 3. ability to understand and speak english 4. access to a telephone exclusion criteria: 1. inability or unwillingness to give informed consent 2. signs of cognitive impairment (blessed orientation-memory-concentration (boms)scores \>10) 3. new york heart association (nyha) functional class\>iii, angina canadian cardiovascular society(ccs) iii and iv or clinically unstable 4. awaiting coronary by-pass or heart transplantation 5. co-morbid life threatening condition 6. ongoing severe depression or psychosis
a randomized controlled trial of exercise training among men with type 2-diabetes

Conditions: Diabetes Mellitus, Type 2; Hyperglycemia

Summary: to test the hypothesis that there is no difference in change in hba1c among men with type 2-diabetes after an exercise intervention with strength versus endurance training.

exercise training is well documented as part of effective treatment for type 2-diabetes patients. endurance training has been suggested as the most suitable form of exercise. there are reasons to believe that strength training also has a positive effect. however, comparisons of endurance training and strength training regimes are limited. therefore we randomized 26 men with type 2-diabetes to either an endurance training group or a strength training group. both groups exercised three sessions per week for three months. the training was supervised.

Eligibility criteria:
inclusion criteria: * diagnosed with type 2-diabetes * male, 35-71 years * managing their diabetes through a lifestyle and/or the drug metformin only * able to participate in either of the exercise groups exclusion criteria: * symptomatic cardiovascular disease * uncontrolled hypertension * physical or cognitive disabilities that will interfere with participating in the exercise regimes. * trained consistently during the last six months.

Keywords: type 2-diabetes exercise therapy rct norway
acceptability and feasibility of mol in acute inpatient units

Conditions: Psychosis; Suicidal

Summary: the current study aims to test the acceptability and feasibility of a psychological therapy called method of levels (mol) as an intervention for people in acute psychiatric inpatient units who are experiencing psychosis and/or suicidality.


Eligibility criteria:
inclusion criteria: * adults over the age of 18 years * current service user in an acute inpatient ward in the greater manchester area * capacity to provide informed consent for participating in research * good command of english language * ws1: experiencing psychosis (this will be screened for using a clinical cut-off score on the cape (mossaheb et al., 2012)) * ws2: experiencing suicidality (this will be screened for using a cynical cut-off score on the suicidal behaviours questionnaire - revised (sbq-r) (osman et al., 2001)) exclusion criteria: * problems of an organic nature or a learning disability that might affect cognitive functioning
neoadjuvant sintilimab plus chemoradiotherapy for locally advanced adenocarcinoma of esophagogastric junction

Conditions: PD-1; Neoadjuvant Chemoradiotherapy; Gastroesophageal Junction Cancer

Summary: the purpose of this study is to access the safety and efficacy of neoadjuvant immunotherapy (sintilimab, pd-1 inhibitor) combined with chemotherapy (s-1+oxaliplatin) and radiotherapy for locally advanced esophagogastric junction adenocarcinoma.


Eligibility criteria:
inclusion criteria: * age 18-70, male and female. * histologically confirmed locally advanced esophagogastric junction adenocarcinoma ct3-4anxm0 (ajcc v8), siewert typed as type ii-iii. * no previous anti-tumor treatment. * ecog score was 0-1. * expected survival of ≥ 6 months * adequate organ reserve function. exclusion criteria: * malignant disease other than gastric cancer (excluding radically treated basal cell carcinoma of the skin, squamous epithelial carcinoma of the skin, and/or radically resected carcinoma in situ) diagnosed within 5 years. * known her-2 positive( ihc 3+ or fish positve). * patients have received immunotherapy, such as pd-1 antibody, pd-l1 antibody and ctla4 antibody * severe allergic reaction to monoclonal antibody. * receiving systemic glucocorticoid therapy within 7 days prior to the first dose of the study * known endoscopic signs of active bleeding from the lesion
biomarkers and unstable carotid plaque

Conditions: Carotid Artery Diseases

Summary: this prospective study investigated associations between circulating mirnas and symptomatic and asymptomatic icas, carotid plaque morphology and future cardiovascular events.


Eligibility criteria:
inclusion criteria: * presence of significant internal carotid artery stenosis referred to carotid artery endarterectomy. * age\>18 years exclusion criteria: * presence of significant internal carotid artery stenosis referred to carotid artery stenting
single transpulmonary thermodilution and continuous monitoring of central venous oxygen saturation during off-pump coronary surgery

Conditions: Coronary Artery Disease; Hemodynamic Monitoring; Goal Directed Therapy

Summary: the aim of the present study was to evaluate the usefulness of an algorithm based on hemodynamic parameters obtained by single transpulmonary thermodilution (std) combined with continuous monitoring of central venous oxygen saturation (scvo2) for perioperative management of patients undergoing opcab.

at the present time, there is an increasing tendency to perform off-pump coronary artery bypass grafting (opcab). however, opcab poses a variety of challenges from the point of view of the anesthesiologist and the intensivist. the aim of the present study was to evaluate the usefulness of an algorithm based on hemodynamic parameters obtained by single transpulmonary thermodilution (std) combined with continuous monitoring of central venous oxygen saturation (scvo2) for perioperative management of patients undergoing opcab.

Eligibility criteria:
inclusion criteria: * patients with coronary artery disease, ranked asa ii-iii and scheduled for elective opcab exclusion criteria: * age \< 18 years * severe valve dysfunction or peripheral vascular disease * simultaneous interventions (carotid endarterectomy, aneurysm repair, etc.) * transfer to cpb during surgery

Keywords: venous oxygen saturation transpulmonary thermodilution
post intensive care unit atrial fibrillation

Conditions: Atrial Fibrillation; Critical Illness

Summary: atrial fibrillation (af) is a common heart rhythm disorder in the intensive care unit (icu). it can be precipitated by multiple factors but it is unclear whether af persists after discharge from the icu, and long term. this study will investigate whether af recurs up to one year after icu discharge.

atrial fibrillation (af) is the most common heart rhythm disorder encountered in the intensive care unit (icu). it can be precipitated by multiple factors present in critically ill patients, such as tissue hypoxia, metabolic disorders etc. there is a paucity of data regarding the persistence of af in these patients after discharge from the icu, and in the longer term. therefore, this study will investigate whether af recurs up to one year after icu discharge using an implantable ecg holter device in adult patients discharged alive from the icu, with documented new onset af.

Eligibility criteria:
inclusion criteria: * age \>18 years * new onset atrial fibrillation diagnosed in the icu (12 lead ecg or documented episode of atrial fibrillation lasting at least 30 seconds) * patient hospitalized in the icu with at least one of the following two criteria: * orotracheal intubation for mechanical ventilation * and/or treatment with amines (vasopressors or inotropic agents) * written informed consent * patient affiliated to a social security regime (or beneficiary thereof) exclusion criteria: * documented history of atrial fibrillation * patients admitted to the icu after cardiothoracic surgery * patients with life expectancy \<12 months * patients under legal or judicial protection * patients with no social security coverage * patients within the exclusion period of another clinical trial

Keywords: intensive care unit atrial fibrillation
protein biomarker discovery and validation in chronic obstructive pulmonary disease (copd) and asthma

Conditions: Asthma; COPD

Summary: the purpose of the study is to better understand proteomics of asthma and copd, and response to therapy. there are two phases to this study broken into two arms. in phase i, we propose is to use discovery proteomics and techniques to identify protein expression signatures. subjects who complete phase i are eligible, but not required, to enroll in phase ii. in phase ii, we propose to establish and validate the predictive value of protein signatures for treatment responses using inhaled corticosteroids.

there are two phases to this study broken into two arms. in phase i, our propose to use discovery proteomics and high throughput techniques to identify protein expression signatures. the total planned size of phase i is 100 patients. patients will be divided into two arms based on disease status (copd or asthma). active smoking will be defined as daily use of cigarettes, pipes, cigarillos or cigars at time of entry into the study and through duration of study. no active smoking defined as never smoking or having stopped smoking for 5 years or greater. in the phase ii, we aim to establish and validate the predictive value of proteomic signatures for therapeutic responses using inhaled corticosteroids. for phase ii, subjects who completed phase i are eligible, but not required to participate in phase ii.

Eligibility criteria:
inclusion criteria: * criteria for asthma inclusion * history consistent with asthma: episodic wheezing, shortness of breath, or cough * airway lability recognized by at least 12% improvement in forced expiratory volume (fev1) after 2 puffs of beta2 agonist age \>18yrs * fev1 \>40% predicted * never smoker, current smoker, or quit smoking ≥5 years ago criteria for copd inclusion * history consistent with copd: dyspnea with exertion, productive cough, progressive course * smoking history of at least 20 pack years * current smoker or quit smoking ≥5 years ago * age \>18yrs * fev1: forced vital capacity (fvc) ratio \< 0.70 following 2 puffs of albuterol * fev1 greater than 50% predicted exclusion criteria: * exclusion for asthma exclusion * other respiratory illness other than asthma * chronic infectious process * significant other medical illness * inability to consent * pregnancy exclusion for copd exclusion * other respiratory illness other than copd * chronic infectious process * significant other medical illness * inability to consent * pregnancy
impact of pharmacist in cardiology service

Conditions: Cardiomyopathy, Diabetic

Summary: the coverage of the diabetes is a multidisciplinary care, with practitioners' implication(hospital and liberal), and other medical and paramedical profession: doctor, pharmacist, male nurse, nutritionist, etc. in fact there is a real importance of link between hospital and general medecine outside. that's why the pharmacist's presence during the hospitalization seems to be a good alternative to make the link between hospital and the outside pharmacist where patient take his treatment. hospital pharmacis proceed to a treatment conciliation at the entrance and at discharge. by this conciliation the aim of the study is to show and quantify the impact of pharmacist presence on therapeutic target .


Eligibility criteria:
inclusion criteria: * diabetes type 2 patient hospitalized in cardiology service * hospitalization more than 24 hours * with insuline or/and oral anti diabetic exclusion criteria: * diabètes type 1 * iatrogenic hyperglycaemia * hospitalization for cardia angiography
bioequivalency study of 300 mg lithium carbonate under fed conditions

Conditions: Bipolar Disorder

Summary: the objective of this study was the bioequivalence of a roxane lithium carbonate 300 mg extended release tablet formulation compared to solvay's lithobid 300 mg extended release tablet under fed conditions using a single-dose, randomized, 2 treatment, 2-period, 2-sequence crossover design.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening. exclusion criteria: * positive test for hiv, hepatitis b, or hepatitis c. * treatment with known enzyme altering drugs. * history of allergic or adverse response to lithium, or any comparable or similar product.
mental health of men before and after testicular cancer treatment

Conditions: Testis Cancer; Cognitive Impairment; Sexual Dysfunction

Summary: this is a prospective observational study, that investigates men diagnosed with testicular cancer before and after treatment. the patients are included at their visit at the fertility clinic in horsens, where they deposit semen for cryopreservation prior to surgery and potential systemic treatment. here the patients, who want to participate will perform a cognitive test and afterwards complete a questioner (t1). after 9 month the patients will be invited to perform the cognitive test and complete the questionnaire again (t2).


Eligibility criteria:
inclusion criteria: * men aged 18 - 45 years. * newly diagnosed testicular cancer and referred to the fertility clinic in horsens fore cryopreservation of semen prior to further treatment. exclusion criteria: * men, who cannot talk, read ore write danish. * men who are not able to give informed consent.

Keywords: sexual health fatigue quality of life depression anxiety fertility concerns sleep quality erectile function cognitive impairment testis cancer
comparison between the effectiveness of different commercial bracket brands

Conditions: Crowding, Tooth, Class I

Summary: there's a scarcity in literature concerning the comparison of the effectiveness of brackets in its torque and tip ability, the time takes for leveling and alignment comparing between different orthodontic bracket brands, and its effect on the rate of tooth movement. the purpose of this study is to determine, in orthodontic patients with class i molar relation and teeth crowding, in which different bracket brands will be compared.

bracket effectiveness can be measured in a variety of ways, including torque, tip, time required for levelling and alignment, bracket failure, and the patient's visual analogue scale. all are viable options; therefore, we want to complete the orthodontic treatment and determine which brackets fulfilled the built-in bracket prescription and achieved success in terms of aesthetics, better smiles, better patient judgement, and function.

Eligibility criteria:
inclusion criteria: * patient with full set of permanent teeth * male and female (14-19 years old). * positive patients' acceptance for the study * patients have no history of previous orthodontic treatment. exclusion criteria: * patients with enamel or dentin defect or any teeth anomaly will be eliminated. * patients having canine or lateral incisors peg shaped will be excluded from the research. - medically compromised patients * patients unable to give an informed consent * patient with periodontal disease * patient taking long term medication * patients with any parafunctional habits (i.e. bruxism, tongue thrusting, mouth breathing)

Keywords: orthodontic bracket brands torque prescription tip prescription levelling and alignment lateral cephalometric radiographs cbct vas
pragmatic research examining inpatient symptoms

Conditions: Postoperative Pain; Nausea; Vomiting; Anxiety; Depression

Summary: many hospitalized patients experience pain during their hospital stay, and less than half report adequate pain relief. common treatments for pain include opioid medications, which have associated side effects and complications. research has shown that acupuncture is effective for surgical, postoperative and cancer-related pain, nausea, and vomiting. more research is needed on the effectiveness of adding acupuncture to routine care for hospitalized patients. the objective of this study is to examine the effectiveness of acupuncture delivered in a "real-world" setting according to the principles of traditional chinese medicine among hospitalized patients to manage pain and other symptoms. 250 hospitalized participants will be randomized in a 1 to 1 ratio to receive either 1) usual care or 2) usual care with acupuncture offered (125 in each group). the primary outcome measure will be change in daily pain intensity. data on other symptoms, such as nausea, vomiting, anxiety, and depression, as well as functionality and quality of life will be collected in person, on a web-based survey, or via telephone follow-up. the aims of the study are to examine the effectiveness of acupuncture to manage pain and other symptoms among hospitalized patients; to evaluate the impact of acupuncture on patient satisfaction among hospitalized patients; and to estimate costs and cost-effectiveness of acupuncture among a subset of hospitalized patients. the investigators hypothesize that compared to hospitalized patients receiving usual care alone, hospitalized patients receiving acupuncture will have: 1. decreased pain severity 2. higher patient satisfaction


Eligibility criteria:
inclusion criteria: * english or spanish speaking * admitted to mt zion hospital for a minimum anticipated length of stay for at least 4 days * aged 18 or older * in a ward included in the roll out of the osher center's acupuncture program at mt zion exclusion criteria: * unstable medical condition (e.g., severe pulmonary disease, myocardial infarction, severe depression, patients in the intensive care unit) * acupuncture contraindication (e.g., sepsis, endocarditis) * inability to consent or complete surveys (e.g., cognitive or communication impairment)

Keywords: acupuncture postoperative pain nausea vomiting anxiety depression hospitalization inpatient
acute hemodynamics of albumin versus normal saline in cirrhosis

Conditions: Cirrhosis; Ascites

Summary: cirrhosis is frequently complicated by derangement of body fluid homeostasis resulting in accumulation of large amounts of extracellular fluid in the peritoneal cavity (ascites) and interstitial tissue (edema). studies showed that patients with cirrhosis and ascites have marked circulatory dysfunction. albumin infusions have been used for many years in the management of patients with cirrhosis and ascites in an attempt to reduce the formation of ascites and/or improve circulatory and renal function. while some of these indications for albumin infusions are supported by the results of randomised studies, others are based on clinical experience and have not been proved in prospective investigations. therefore, the use of albumin infusions in patients with cirrhosis is controversial. recently, this debate has been fostered by the high cost and limited availability of albumin and the results of a meta-analysis showing that albumin administration may increase mortality in critically ill patients. in cirrhotics, there is a significant improvement in the low effective arterial blood volume, which may be important in the prevention of circulatory dysfunction and in preventing renal impairment. however, in an already fluid overload state such as that of cirrhosis, albumin infusion predisposes the individual to develop pulmonary edema. there is no study demonstrating acute effect of albumin infusion on hemodynamic parameters, in cirrhotic patients. neither is there is data concerning comparison between albumin and normal saline. it is postulated that it may increase portal pressure thereby increasing the risk of variceal bleed. this study hypothesizes that albumin infusion might lead to alteration in portal and pulmonary hemodynamics in decompensated cirrhotic patients. included patients of cirrhosis with ascites (based on inclusion and exclusion criteria) will undergo baseline investigations (systemic hemodynamics, pulmonary hemodynamics, portal hemodynamics). they will be randomized into two groups, each of 8. one group will receive infusion of 100 ml 20% albumin over 3 hours, and the other will receive infusion of 100 ml normal saline over 3 hours. repeat hemodynamic studies will be performed after the infusion finishes. all results will be expressed as mean ± sd or frequency (%). comparisons will be performed by the student's t test or with the wilcoxon's test


Eligibility criteria:
inclusion criteria: 1. patients with cirrhosis with ascites admitted to the ge ward 2. they require intravenous albumin therapy, for the management of their cirrhotic ascites 3. their serum albumin \<2.8 g/dl exclusion criteria: 1. cirrhotics without ascites 2. acute on chronic liver failure 3. serum bilirubin \>3 mg/dl 4. hepatorenal syndrome 5. patients suffering from heart disease, history of allergy to albumin, pregnant women, hypertension, chronic nephritis 6. lack of informed written consent

Keywords: decompensated cirrhosis with ascites