Kornimate/medical-research-clean huggingface dataset:
accuracy of endo-aid in consecutive patients referred for colonoscopy

Conditions: Adenoma Colon; Colonic Adenoma

Summary: the goal of this clinical trial is to evaluate the diagnostic yield of cade in a consecutive population undergoing colonoscopy. the main question it aims to answer is the adenoma detection rate (adr). participants undergoing colonoscopy will be randomized in a 1:1 ratio to either receive computer-aided detection (cade) colonoscopy or a conventional colonoscopy (cc). researchers will compare the cade group and the cc-group to see if cad-e can increase the adr significantly.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years or ≤85 * patients undergoing screening, follow-up, or diagnostic colonoscopy exclusion criteria: * suspected or known inflammatory bowel disease * colonic resection * taking anticoagulants or antiaggregants that contraindicate the performance of therapy * patients with incomplete colonoscopy * patients with inadequate preparation using the boston colonic preparation scale (bbps). a cleaning quality of less than 2 points in any of the 3 colonic sections will be considered inadequate. * inability to provide informed consent.

Keywords: adr cade endo-aid
application of laparoscopy in gastrointestinal injury

Conditions: Gastrointestinal Injury

Summary: laparoscopy has been increasingly applied in patients with abdominal trauma , as an diagnostic and therapeutic modality. however, its clinical benefits are still under evaluation. the aim of this study is to prospectively assess the feasibility and safety of this technique in the management of traumatic gastrointestinal injury.

this prospective single arm study was undertaken in west china hospital, sichuan university, chengdu, china. the institution is the largest medical center in southwest china, and also a national training center of laparoscopy. surgeons participated in the study were well trained in gastrointestinal laparoscopy and hepatobiliary laparoscopy, and were experienced in management of abdominal trauma. the study was approved by the institutional review committees. the participants provided written informed consent. patients age 18 years or older with abdominal trauma were considered eligible, regardless of the nature of trauma (blunt or penetrating), but hemodynamic stability was mandatory. patients meet the following criteria is prepared for laparoscopic exploration: evidence showed that wound penetrates the peritoneum in penetrating trauma or/and signs of peritoneal irritation or positive ct scan in those without penetration of peritoneum and patients with blunt injuries. we defined the ct scan positive by it shows peritoneal effusion, free intraperitoneal air, fat density increase, substantive organ rupture and intestinal wall swelling and other signs of abdominal trauma. laparoscopic screening will be performed according to protocol. the study demands that all surgeons should complete the repair laparoscopically as much as possible when condition allow, and record reasons for conversion in detail when it is inevitable.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of gastrointestinal trauma * blood loss \< 1000ml * hemodynamically stable * vital sign is stable * willing to comply to the study procedure and complete the study. exclusion criteria: * severe hemorrhage or intraperitoneal infections * combined with other conditions which are contraindications to laparoscopy * pregnant or lactating woman * severe immunodeficiency * history of drug abuse

Keywords: trauma gastrointestinal injury laparoscopy
myval transcatheter heart valve system - prospective german multicenter registry

Conditions: Aortic Valve Stenosis

Summary: rational of the myval thv - prospective german multicenter registry is to evaluate the performance of this relatively new but very promising tavr valve in a consecutive real-word, all-comers registry and to assess the long-term durability and efficacy of the myval thv.


Eligibility criteria:
inclusion criteria: * patient is going to be treated with myval thv * age ≥ 18 years * ability to give informed consent exclusion criteria: * pregnant and lactating women * patients with hyper sensitivity or allergy to aspirin, heparin, clopidogrel, ticlopidine, cobalt, nickel, chromium, molybdenum or any contrast media. * patients in whom anti-platelet and/or anticoagulant therapy are contra-indicated. * any condition, which in the investigator's opinion, would preclude safe participation of patient in the registry
evaluation of the learning curve in low anterior resection for rectal resection with the two surgical robots

Conditions: Rectal Cancer

Summary: central south university in collaboration with tianjin university developed the first domestically produced chinese minimally invasive surgical (mis) robot system which named "micro hand s" in 2013. this new mis robot had been authorized to enter the clinical trial stage by the ethics committee of the third xiangya hospital at central south university. the micro hand s robot is safe and feasible in the preliminary study. however, the learning curve in low anterior resection for rectal resection with the micro hand s robot are unclear and whether the two surgical robots (micro hand s and da vinci) shared a similar learning curve and the two robot can be trained simultaneously. therefore, the investigators conduct this retrospective study to focus on this concern.

the micro hand s robor has been appiled in low anterior resection for rectal cancer. the safey and feasibility has been evaluated. however, the learning curve of this procedure is unclear. specially,whether the two surgical robots (micro hand s and da vinci) shared a similar learning curve and the two robot can be trained simultaneously are unclear.therefore, this srudy is conducted to evaluate the learning curve of the two robots in low anterior resection.

Eligibility criteria:
inclusion criteria: * histologically confirmed rectal cancer; asa score ≤ 3 exclusion criteria: * palliative resections, combined resections, distant metastasis, a previous history of abdominal/or pelvic surgery
healthy lifestyles for people with intellectual disabilities

Conditions: Mental Retardation; Developmental Disabilities; Intellectual Disabilities

Summary: relatively few health promotion and disease prevention programs have included or targeted people with disabilities, and even fewer have focused on individuals with intellectual disabilities. the long-term objectives of the healthy lifestyles for people with intellectual disabilities study (hlid) are to increase the health of persons with intellectual disabilities by establishing the efficacy of a health promotion program and promoting its adoption. the hlid study is based in the center on community accessibility (cca) at oregon health \& science university. the mission of cca is to increase the health and health-related quality of life of persons with disabilities. a pilot study conducted by cca has established the effectiveness of the healthy lifestyles (hl) intervention among a cross-disability population in increasing health behavior adoption. the specific aim of the hlid study is to test the efficacy of the hl program specifically with adults with intellectual disabilities. the hlid study uses a randomized control study design. the hl intervention will be administered to 75 adults and will compare results to those of an additional 75 adults who receive no intervention. measurement will include anthropometric assessments to measure impacts on overweight and obesity, as well as self-report measures of healthy behaviors, health status, health care utilization, and secondary conditions. results will be shared with research participants, presented through professional conferences and newsletters, and published in peer-reviewed journals with the assistance of community partners.


Eligibility criteria:
inclusion criteria: * living in oregon or southwest washington * ages 18-65 years * have mild or moderate mental retardation/developmental disability/intellectual disability as defined by oregon or washington state (depending on place of residence) developmental disability service delivery system * eligible in oregon or washington (depending on place of residence) to receive services for people with mental retardation/developmental/intellectual disability * living in the community (i.e., group home, with family/friends, on own with or without support) * participant defined health status of excellent, good, or fair * participant expressed interest in participation in study * participant expressed willingness to be assigned to either workshop or control study group

Keywords: mental retardation downs syndrome autism autism spectrum disorder cerebral palsy developmental disability developmental disabilities intellectual disability intellectual disabilities health promotion disease prevention physical health emotional health behavioral health mental health spiritual health prevention
outpatient treatment of low-risk pulmonary embolism

Conditions: Pulmonary Embolism

Summary: this study is looking at the safety and effectiveness of treating patients diagnosed with a low-risk pulmonary embolism (pe) in an outpatient setting instead of the standard, in-patient hospitalization. patients have several medical tests done during their emergency department visit. based on those tests, those who are determined to have a low-risk pe are eligible to participate in the study. those choosing to participate are discharged after 12 hours of medical observation. patients who choose to participate are followed up by telephone approximately 90 days later.


Eligibility criteria:
inclusion criteria: 1. pulmonary embolism, diagnosed by cta or high probability vq scan 2. total pulmonary embolism severity index (pesi) score \<86 exclusion criteria: 1. massive pulmonary embolism: hypotension with signs of right heart strain on cta or echocardiogram 2. sustained systolic blood pressure (sbp) \<95 mmhg during emergency department or observation stay. 3. age \<18 4. pregnant 5. renal insufficiency (creatinine clearance \<30) 6. hepatic dysfunction (ast/alt/alp \> 3 times upper limit of normal) 7. unreliable social situation or inability to follow up 8. contraindication to enoxaparin, warfarin and rivaroxaban 9. atrial or ventricular dysrhythmia(s)
development of real-time image-guided radiotherapy

Conditions: Breast Cancer; Lung Cancer; Skin Cancer

Summary: the goal is to achieve the maximal radiotherapy tumor dose while sparing the health tissue and critical structures. on-board cone-beam ct (cbct) scans are routinely acquired prior to dose delivery and matched with simulation ct at the planned treatment positions. thus, setup or motion errors can be detected and corrected. however, cbct is not available for situations with gantry collisions such as wbi and tseb. more importantly, cbct cannot reveal any irregular respiration or body movement during beam-on time. thus, it is essential to develop a real-time image system that can detect organ/body motion during beam-on time, and correlate simulation-planning images with prior treatment cbct images.in this proposed clinical trial, we will cooperate with a 3d camera company (xigen llc) to develop novel 4d video imaging techniques and validate the feasibility and accuracy of 4d video image guidance in correlation with 4d ct/cbct useful for advanced igrt.


Eligibility criteria:
inclusion criteria: * all patients benefit from advanced igrt can participate to the study except for those emergent and pediatric patients (age \<18 years) who require special care or there is no time for the setup the 4d video systems * the patient population would be selected according to the technical progress and clinical needs exclusion criteria: * none
effects of free fatty acids and 3-hydroxybutyrate on protein, glucose, lipid metabolism and intracellular signals.

Conditions: Systemic Inflammatory Response Syndrome

Summary: the investigators hypothesize that the investigators can detect protein-sparing effects of administration of the ketone 3-hydroxybutyrate and free fatty acids during simulation of an acute inflammatory disease. the investigators use the infusion of endotoxin, us standard reference e.coli in healthy subjects as a model for inflammation / infection and to evaluate the effect on protein metabolism using different tracers and the investigators can measure the various intracellular signaling pathways of selected muscle and adipose tissue.


Eligibility criteria:
inclusion criteria: * 20 \< body mass index \< 30 kg/m2. * written and orally informed consent before enrollment. exclusion criteria: * participation in other studies using radioactive tracers or other exposure to radiation (x-rays, scintigraphy etc). * allergy to soy products or eggs * diabetes, any type * epilepsy * ongoing infection * immune deficiency * cardiovascular disease * dysregulated hypertension * primary muscles disease, congenital or acquired

Keywords: sepsis cytokine release fever
safety and efficacy study of prv111 in subjects with oral squamous cell carcinoma

Conditions: Oral Squamous Cell Carcinoma

Summary: up to 31 subjects diagnosed with oral squamous cell carcinoma received one application of a permeation enhancer 3 treatment applications of a cisplatin drug-loaded patch to the tumor site at each of the 4 treatment visits. these 4 treatment visits were scheduled to occur during the 3 weeks prior to the standard of care tumor resection. funding source: fda oopd

up to 31 subjects diagnosed with oral squamous cell carcinoma received one application of a permeation enhancer and 3 treatment applications of a cisplatin drug-loaded patch to the tumor site at each of 4 treatment visits. these 4 treatment visits were scheduled to occur during the 3 weeks prior to the standard of care tumor resection. after the surgery, subjects were followed for 6 months for disease recurrence. ten subjects were enrolled in the study. up to 21 additional subjects could have been enrolled in stage 2, if safety and efficacy endpoints were not met. the dose was not changed. all subjects were followed for 6 months post-surgery for disease recurrence. during and at the conclusion of the treatment period, subjects were monitored for local and systemic safety, tumor response due to the treatment, and systemic drug exposure.

Eligibility criteria:
inclusion criteria: 1. pathologically confirmed t1 (\ 2 cm but \< or = 4 cm) squamous cell carcinoma (scc) of the lip or oral cavity (anterior 2/3 of the tongue, floor of mouth, lower and upper gingiva, salivary gland, hard palate, and buccal mucosa). 2. tumor must be easily accessible, with no evidence of infection or active bleeding, encroaching major vessels or clinical evidence of neural invasion. not previously irradiated. 3. tumors must be amenable to surgical resection no later than 21 days post visit 1. 4. clinically or radiologically measurable tumor. 5. ecog performance status of \< or =2. 6. adequate renal function as demonstrated by renal creatinine clearance. 7. adequate organ function as assessed by safety labs. 8. agree to use effective contraception for 30 days after the last dose of study drug. 9. absence of any serious medical conditions that would impair the subject's ability to participate. 10. willing and able to provide written informed consent. 11. able to return to the study site for treatment and follow-up visits as defined in the protocol. exclusion criteria: 1. known distal metastasis of the scc of the oral cavity. 2. systemic chemotherapy for the treatment of scc of the head and neck less than 2 years prior to screening. 3. concurrent documented malignancy, with the exception of localized scc of the skin. 4. exposure to any investigational agent within 3 months prior to screening. 5. known allergy or hypersensitivity to platinum-containing agents. 6. active, uncontrolled infection requiring systemic therapy. 7. known or suspected pregnancy, planned pregnancy or lactation.
warmed, humidified carbon dioxide insufflation vs standard carbon dioxide in laparoscopic cholecystectomy

Conditions: Cholecystolithiasis

Summary: the purpose of this study is to determine the effect of warmed, humidified carbon dioxide insufflation vs standard carbon dioxide in laparoscopic cholecystectomy.

patients undergoing warmed, humidified carbon dioxide (co2) insufflation for laparoscopic cholecystectomy will have less postoperative pain than patients undergoing laparoscopic cholecystectomy with standard co2 insufflation. the study design is a double-blind, prospective, randomized study comparing patients undergoing laparoscopic cholecystectomy with standard co2 insufflation vs those receiving warmed, humidified co2. main variables included postoperative pain (rated with a visual analog scales) and analgesic requirements.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of cholecystolithiasis exclusion criteria: * clinical diagnosis of cholecystolithiasis with cholecystitis

Keywords: pain
effects of osteopathic manipulative treatment on postural control in parkinson's disease/pisa syndrome patients

Conditions: Parkinson Disease and Pisa Syndrome

Summary: the aim of the study is to evaluate the efficacy of osteopathic manipulations added to an intensive, multidisciplinary rehabilitative (mirt) program on postural control of pd-ps patients.

pisa syndrome is frequently associated with parkinson disease and it is characterized by a trunk lateral flexion higher than 10 degrees that is reversible with the lying position. its pathophysiology is multifactorial, and it is probably different depending on disease onset duration. however, a relevant association between subjective visual vertical misperception and the ps involved side was recently described. moreover, an impairment in postural control in pd-ps patients has been recognized. nowadays, physical therapy is the standard treatment and it is proposed to ameliorate paraspinal muscle hyperactivity and balance, as showed by previews descriptive and clinical studies. despite being physical therapy a cornerstone in pd-ps axial symptoms treatment, the therapeutic protocol for postural control in pd-ps patients is under active study. in recent years, preliminary studies described the effects of osteopathic manipulative treatment on motor functionality and balance in pd patients in a multidisciplinary setting, which is in line with the evidence of the need of a multidisciplinary and intensive approach to achieve better outcomes. however, the effect of omt has never been investigated in pd-ps patients. the aim of the study is to evaluate the effects of omt on postural control of pd-ps patients undergoing the mirt program. literature reported the possible benefit of omt on the balance of healthy subjects, possibly interacting with the multisensorial integration of balance. 24 pd-ps patients are enrolled and randomized in two groups. posturography is performed to assess eye-closed sway area (ecsa) at baseline and 30 days after enrolment. the investigator who perform posturography and trunk inclination assessment is kept blinded. trunk inclination is measured with "diers formetric 4d". other variables considered in the investigation are eye-opened sway area (eosa), trunk lateral flexion (tlf), kyphothic angle (ka), unified parkinson disease rating scale (updrs), six-minute walking test (6mwt).

Eligibility criteria:
inclusion criteria: * pisa syndrome and parkinson disease * ps onset \&lt; 12 months * tlf \&gt; 10 degrees exclusion criteria: * scoliosis or spine deformity * changes of pd pharmacological therapy within 3 months * co-morbidity with other neurological disease
serum ferritin and prognosis of dka

Conditions: Diabetic Ketoacidosis

Summary: the aim of this study is to: evaluate the association between serum ferritin levels and the clinical presentation and short-term prognosis of patients with dka. specifically, the correlation between its level and the severity of dka at presentation and determine its prognostic value in predicting short-term outcomes.

ferritin studies and correlation to acute events like stroke or mi was done before, however some studies have found a correlation with the degree and prognosis of these diseases and others not. however no study was tried on dka patients before so the investigators are trying to find if ferritin would have a relation with patients of dka and could be used as a prognostic tool (for example we found in this study when level is less than "200" patients mostly has good prognosis) this is just an example or (serrum ferritin turned out to be irrelevant to dka prognosis as patients would have good prognosis despite number value) and this will be in selected patients according to criteria to exclude any chronic condition in the investigators hospital care units.

Eligibility criteria:
inclusion criteria: - all patients with dka : 1. adult aged 18 years old or older . 2. type 1 dm , type 2 dm 3. diagnosis of dka based on the american diabetes association criteria: blood glucose \>250 mg/dl, arterial ph \<7.3, serum bicarbonate \<18 meq/l, exclusion criteria: 1. patients age less than 18 years old 2. iron deficiency anemia and iron overload 3. chronic inflammatory diseases: conditions such as rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel disease 4. acute and chronic infections, including bacterial, viral, and fungal infections 5. pt presented with other acute complication (mi,stroke) 6. ckd patients 7. patients with chronic liver diseases 8. patients with malignancy 9. pregnant women.

Keywords: serum ferritin diabetic ketoacidosis
monitoring of postoperative residual neuromuscular blockade in laparoscopic surgery

Conditions: Neuromuscular Block, Residual

Summary: compare the reversal effect of neostigmine and sugammadex using quantitative neuromuscular monitoring

at the end of surgery, decide the dosage of reversal referring to quantitative neuromuscular monitoring value (tof). after the administration of reversal, the anesthesiologist who are going to manage the participant should not check the quantitative neuromuscular monitoring and determine the timing of extubation only with his (or her) judgement. after entering post-anaesthesia care unit (pacu) measure the tof value and check the incidence of tof ratio \> 0.9 between the neostigmine group and sugammadex group.

Eligibility criteria:
inclusion criteria: * patients aged over 18 years, planned to undergoing elective laparoscopic surgery under general anesthesia exclusion criteria: * obesity bmi over 30 kg/m2 * impairment of renal or/and liver function * allergy to rocuronium, sugammadex * (familial) history of malignant hyperthermia * taking medicines which is affecting neuromuscular function