Kornimate/medical-research-clean huggingface dataset:
resveratrol for pain due to endometriosis

Conditions: Endometriosis

Summary: this study aims to verify whether the use of 40 mg of resveratrol per day associated with monophasic contraceptive pill (levonorgestrel 0.15mg/ethinyl estradiol 0.03mg) reduces pelvic pain at the end of 2 months of treatment, compared to the use of the pill with placebo.

endometriosis is a disease that affects 176 million women around the world, and it is present in about 60% of adolescent women with chronic pelvic pain and dysmenorrhea. some researchers have investigated the antiproliferative effect of resveratrol in endometriosis using animal models and humans. the reduction in the size and activity of the endometriotic implants has been observed with the use of resveratrol. the reduction of pain in patients with endometriosis is an important aspect of the quality of life. the use of a medication with few side effects and the lack of clinical quality trials justify this study, which aims to verify whether the use of 40 mg of resveratrol per day associated with monophasic contraceptive pill reduces pelvic pain at the end of 2 months of treatment, compared to the use of the pill with placebo. this study will be randomized, prospective, double blind with two arms of 22 patients; the consort parameters will be followed. the degree of pain by visual analog scale, prolactin levels (ng / ml) and the carcinoembryonic antigen levels (ca125) (iu / l) will be measured at the begging and at the end of trial. these parameters will be the outcomes.

Eligibility criteria:
inclusion criteria: * endometriosis diagnosed by laparoscopy exclusion criteria: * known allergy to resveratrol * use of gonadotropin or danazol in the last month

Keywords: resveratrol
the efficacy, safety and toleration of cp-866,087 in pre-menopausal women with female sexual arousal disorder.

Conditions: Sexual Dysfunction, Physiological

Summary: cp-866,087 is a non-hormonal compound, acting on the central nervous system, which has been shown in animal models to restore sexual function.


Eligibility criteria:
inclusion criteria: * healthy pre-menopausal women * primary female sexual arousal disorder causing distress * on stable use of oral contraceptives exclusion criteria: * any other significant disease causing female sexual dysfunction including psychiatric disease * subjects on drugs known to cause female sexual dysfunction * subjects who have given birth in the last 12 months or who are planning to become pregnant during the study
effects of emg-driven robot-assisted therapy for the distal upper limb motor function in the chronic stroke patients with botox injections

Conditions: Chronic Stroke; Spasticity as Sequela of Stroke; Robotic Rehabilitation

Summary: over fifty percent of stroke patients experience chronic arm hand performance problems, compromising independence in daily life activities and quality of life. traditionally, the effectiveness of rehabilitation in improving functioning for stroke patients more than 6 months has not been proven. however, spontaneous neurological recovery reaches the plateau at 3\~6 months later. hand of hope is a virtual reality (vr)-based, electromyography (emg)-driven, and task-oriented hand robot. otherwise, it needs patients to have active participation during the intervention which is critical for motor recovery after stroke. robotic rehabilitation devices have the potential to deliver high-intensity, reproducible therapy. robot-assisted task-oriented training had been proposed by several researchers, but the evidence of clinical effectiveness in highly functional chronic stroke patients is still lack. spasticity is a common disorder which occurs following stroke. the prevalence of post-stroke spasticity can be as high as 46% in the chronic phase (over 3 months). spasticity impacted activities of daily living, quality of life, pain, and functional impairments. long-term spasticity may lead to tendon contracture and limb deformities. botulinum toxin injection, which mostly used in chronic phase (over 6 months), had been proved to be a safe agent representing the gold standard treatment for focal spasticity, while avoiding systemic effects. but the effects of botulism toxin on functional ability are still unclear. moreover, there is insufficient evidence on adjunctive therapies following botulism toxin. the purpose of the present study is to examine the effects of botulinum toxin injection combined with hand of hope and standard occupational therapy on upper extremity function, and compares the findings to those of amount-matched chronic stroke survivors who received only botulinum toxin injection and standard occupational therapy.


Eligibility criteria:
inclusion criteria: * aged between 20-85 year-old * the onset of stroke must be at least 6 month previously * the stroke must be the first event * the stroke must be unilateral brain lesion * spasticity measured as modified ashworth scale during 1+ to 3 * score at least 1 point in the wrist subtest of fugl-meyer assessment * brunnstrom stage of proximal upper limb at least 3, distal upper limb between 2 to 5 * no impairment in visual tracking ability * no impairment in proprioception exclusion criteria: * severe joints pain of hand or finger at affected limb * fracture of affected limb in three months * brunnstrom stage of proximal upper limb not more than 2, distal upper limb more than 5

Keywords: hand of hope hand robot botulinum toxin
premedication on sevoflurane induction

Conditions: Anesthesia

Summary: the goal of this study was to investigate the effects of fentanyl-midazolam premedication during sevoflurane induction pertaining to time to loss of eyelash reflex (ler), time and conditions of insertion of proseal laryngeal mask airway (plma), as well as cardio-respiratory data. participants' anxiety level was also evaluated.

eighty adult patients undergoing minor surgery were randomized in a double-blind fashion. each group received either a nacl placebo (nacl), or a premedication consisting of fentanyl 0,6 ug/kg and midazolam 9 ug/kg (fm), five minutes before tidal volume sevoflurane 8% induction with 6 l/min o2. times to ler and lma insertion were recorded. adverse events were also noted. systolic blood pressure (sbp), heart rate (hr), respiratory rate (rr) and tidal volume (vt) were recorded at one-minute intervals. end-tidal sevoflurane (etsevo) and end-tidal co2 (etco2) were noted immediately following lma insertion. anxiety levels (0-10 verbal scale) were registered before and after premedication. patients were contacted 24 hours postoperatively and were asked if they remembered the mask being applied to their face.

Eligibility criteria:
inclusion criteria: * asa physical status i-ii * minor elective surgery * general anesthesia exclusion criteria: * gastroesophageal reflux * exhibited a body mass index \> 32 kg/m2 * took sedative or opioid drugs.

Keywords: sevoflurane induction premedication laryngeal mask airway anesthesia, inhalation [e03.155.197.197]
questionnaire for metabolic screening

Conditions: Metabolic Evaluation

Summary: the purpose of this study is to determine if kidney stone patients who should have received metabolic tests (urine collection over 24-hours that determines the composition of urine) based on canadian urologic association (cua) guidelines did in fact receive them, and if these results were explained to them by their doctor.

purpose: the purpose of the project is to determine whether metabolic workups are administered to canadian kidney stone patients in accordance to cua (canadian urologic association) guidelines. additionally, the study will look to evaluate whether the results of metabolic tests were sufficiently explained to patients by their doctors, and also whether or not patients would follow dietary or treatment plans to possibly prevent kidney stones based on these metabolic workups. hypothesis: the investigators hypothesize that the implementation of metabolic tests based on cua guidelines is sub-optimal and that when they are prescribed, doctors do not adequately explain these results to patients. the investigators also hypothesize that patients would follow dietary and treatment plants to prevent recurrent stone formation based on these metabolic results - if they are prescribed to the patient. justification: the investigators believe that implementation of metabolic workups is sub-optimal. the investigators would like to confirm this so that, in the future, metabolic workups can be promoted as an appropriate tool for identifying metabolic abnormalities that contribute to stone disease. if metabolic workups are administered and explained adequately to patients then further diet or treatment plans can significantly reduce recurrence of stones in stone patients. objectives: 1. determine if metabolic workups were administered when they should have been according to cua guidelines. 2. for patients who received metabolic workups, determine if the results from metabolic workups were explained to patients, and if so was it done adequately (did the patient understand the explanation) 3. determine patient compliance regarding dietary and treatment plans based on metabolic workups research design: this is a survey based study (one time completion) given to patients pre-eswl. the surveys will be analyzed by research staff to determine the study objectives.

Eligibility criteria:
inclusion criteria: * at least 19 years of age, with at least 1 stone episode, ability to consent exclusion criteria: * inability to provide informed consent, under 19 years of age

Keywords: metabolic screening 24 hour urine
educational intervention to promote control behaviors and prevention of dengue

Conditions: Dengue

Summary: this study will assess the effect of an educational nursing intervention in adults to promote dengue control and prevention behaviors, in comparison with the usual strategy of a health service provider institution. the intervention uses the nola pender health promotion model as a theoretical framework. findings will be assessed using the nursing outcomes "risk control" and "participation in health care decisions" from the nursing outcomes classification (noc).

annually, there are 390 million cases of dengue, mostly due to the inadequate application of sanitary behaviors in the management and control of the vector, having as background the lack of knowledge of the population in the appropriation and incorporation of sanitary measures in the different environments. in addition to the cognitive and behavioral component, dengue has cultural, political, social and economic causes. the evidence indicates that, from health education, educational interventions have been developed to reduce the disease, but most of them have not been carried out in rural areas following a theoretical framework that guides the intervention that leads to an impact on health promoting behaviors. the use of the noc results makes it possible to visualize the impact of nursing care and constitute scientific support for the advancement of the nursing discipline.

Eligibility criteria:
inclusion criteria: * adults ≥ 18 years old. * inhabitant of the rural area. * participant in health promotion and disease prevention programs. * initial score less than or equal to 3.5 on the noc outcomes: risk control and participation in health care decisions. exclusion criteria: * people with a score less than or equal to 24 on the cognitive mini mental test. * incomplete registration of information in databases of a health service provider institution. * people with dengue (dengue with warning signs, and severe dengue). * people who do not have mobile phone availability. * illiterate people.

Keywords: standardized nursing terminology prevention & control dengue
post-operative drainage after pancreaticoduodenectomy

Conditions: Pancreatic Cancer

Summary: the study compares regular use of surgical drains and no use of surgical drains in patients subjected to pancreaticoduodenectomy with expected low to intermediate risk for post operative pancreatic fistula.


Eligibility criteria:
inclusion criteria: * patients undergoing pancreaticoduodenectomy of both sexes * patients with predicted risk score of 10 or less of pancreatic fistula * written informed consent * expected survival time \> 6 months exclusion criteria: * patients with predicted high risk of fistula with a risk score above 10 * patients with intraabdominal abscess or infection * asa score \> 3 * pregnancy * expected lack of compliance
determination of the ed50 and ed95 of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients undergoing major abdominal surgery

Conditions: Norepinephrine; Post-induction Hypotension

Summary: the goal of this clinical trial is to determine the ed50 and ed95 of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients undergoing major abdominal surgery using up-and-down sequential method . the main question it aims to answer is: what is the effective concentration of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients. participants will receive different concentrations of norepinephrine infusion at the beginning of anesthesia induction until 15 minutes after intubation.


Eligibility criteria:
inclusion criteria: * aged 65 to 80 years * undergoing major abdominal surgery * american society of anesthesiologists (asa) physical status of i/ii/iii exclusion criteria: * patient refusal * severe untreated or uncontrolled hypertension despite medications * bradycardia (heart rate \< 50 beat per minute) * cardiac morbidities, heart block greater than the first degree * severe hepatic and renal dysfunction * hyperthyroidism * vascular diseases * bmi\>30 * monoamine oxidase inhibitors were used 2 weeks before surgery
exercise capacity in copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: in this study, cardiopulmonary exercise will be assessed to characterize the relevance of severity of copd and coexisting cardiovascular comorbidities for exercise capacity.

in patients with chronic obstructive pulmonary disease (copd) the interpretation of dyspnoea also needs to consider coexisting cardiovascular disease. cardiopulmonary exercise testing (cpet) is used to characterize pulmonary and cardiac function and limitations during exercise. the investigators hypothesise that cardiopulmonary exercise is reduced in copd patients with coexisting cardiovascular disease as well as in more symptomatic patients and in patients with frequent exacerbations. for this purpose, 100 patients with with stable copd are characterized by clinical characteristics, laboratory tests, lung function, electrocardiography, echocardiography and cardiopulmonary exercise testing.

Eligibility criteria:
inclusion criteria: * patients with stable chronic obstructive pulmonary disease, exacerbated or stable * 40-80 years * sinus rhythm * informed written consent exclusion criteria: * inability to give written consent * acute myocardial infarction with st-segment elevations in last 30 days * severe acute or chronic renal dysfunction * severe heart failure- * atrial fibrillation * severe valve disease * severe hypoxemia * long term oxygen therapy or non invasive ventilation

Keywords: cardiopulmonary exercise testing cardiovascular comorbidities cardiopulmonary interaction
low doses corticosteroids as adjuvant therapy for the treatment of severe h1n1 flu

Conditions: Pneumonia, Viral; Influenza in Humans

Summary: the h1n1 flu pandemic is one of the major infectious threat of the past half century. it is rapidly progressing worldwide and a substantial number of patients get severe h1n1 related pneumonia that requires mechanical ventilation and admission to the intensive care unit. the acute respiratory distress syndrome is associated with a substantial mortality and morbidity partly as a consequence of uncontrolled lung and systemic inflammation. many physicians are trying to counteract this pro-inflammatory storm by the use of corticosteroids albeit these drugs may cause super infection or metabolic disorders. thus, there is a need for a randomized double blind, placebo controlled trial to define the benefit to risk ratio of corticosteroids in this patient.


Eligibility criteria:
inclusion criteria: * age above 15 years old * admitted to intensive care unit * proven or strong suspicion of h1n1 influenza infection * diffuse pneumonia (for less than 96 hours) * need for non invasive or invasive mechanical ventilation exclusion criteria: * pregnancy * an age of 15 or less * rapidly fatal underlying disease with a life expectancy of one month or less * more than 3 organ dysfunction upon admission * previous treatment with corticosteroids (ie prednisone 30 mg per day or more, or equivalent, for at least one month) * formal indication for corticosteroids (eg addison disease, status asthmaticus) * already on corticosteroids for 2 days or more in the management of the current episode * acute lung injury not related to viral pneumonia * presence of h1n1 related acute myocarditis or encephalitis * receiving antiviral treatment for more than 5 days

Keywords: acute lung injury acute respiratory distress syndrome corticosteroids inflammation
prospective multicenter study in patients with a tumor benign ovarian presumed on the use of algorithms such as roma and rmi and tumor markers such as ca125 and he4

Conditions: Ovarian Tumor; Ovarian Cancer

Summary: ovarian cancer is the fifth leading cause of cancer death in women worldwide. most of these cancers are manifested in the form of an ovarian cyst. practitioners are faced with two main difficulties. the first is to establish an early diagnosis. the second is to differentiate a benign tumor, a malignant tumor. to date, there is only one biological tumor marker routinely performed before an ovarian cyst, the ca-125 (cancer antigen 125). unfortunately, many studies have been performed and show a sensitivity and specificity unsatisfactory in view of the severity of the disease. the principal investigator therefore propose to evaluate a new tumor marker, as well as its use in algorithms to help differentiate benign from malignant tumors, and allow earlier diagnosis in cases of ovarian cancer.


Eligibility criteria:
inclusion criteria: * patients to undergo surgery for an ovarian cyst * presumed benign ovarian tumor (according to the rules of the iota(international ovarian tumor analysis group) group) * agreement to participate in the study exclusion criteria: * pregnant patient * minor patient * patient under guardianship, trusteeship, or deprived of liberty * patient with ascites or metastases or malignant ovarian mass presumed under the rules of iota group. * patient with an adnexal torsion is suspected * patient unable to understand the proposed study
a registration study on depression in patients with epilepsy

Conditions: Epilepsy; Depression

Summary: the aim of this study is to register the drug treatment of depression in patients with epilepsy in east china.

as the treatment rate for depression in epilepsy is unclear and the discordant voice of choosing antidepressants for most doctors, this prospective observational cohort study was designed to better understand the current situation of drug treatments in patients with the comorbidity of epilepsy and depression in east china. the secondary outcome was to investigate whether baseline depressive symptoms had an influence on seizure-control in patients with epilepsy at follow-up.

Eligibility criteria:
the inclusion criteria were as follows: (1) age 18-75, no gender limited; (2) diagnosis of epilepsy according to the definition by ilae in 2014; (3) the score of 17-item hamilton depression rating scale greater than 7; (4) obtaining informed consent of participants. the exclusion criteria were any of the following: (1) having psychiatric symptoms such as hallucination or delusion; (2) progressive neurological diseases and malignant tumors; (3) severe cognitive dysfunction (the score of mmse less than 10).

Keywords: epilepsy depression drug treatment
post-marketing surveillance of donepezil hydrochloride -investigation of the factors that affect aricept medication persistence rate and the safety and efficacy in patients with alzheimer's disease in clinical practice

Conditions: Alzheimer's Disease

Summary: to investigate the factors that affect aricept medication persistence rate and the safety and efficacy in patients with alzheimer's disease in clinical practice


Eligibility criteria:
inclusion criteria: patients diagnosed with alzheimer's disease and administered aricept for the first time. exclusion criteria: patients with a history of hypersensitivity to any ingredients of aricept or piperidine derivatives.

Keywords: alzheimer's disease donepezil hydrochloride
myocardial perfusion and contractile reserve in end-stage renal disease

Conditions: End-Stage Renal Disease; Cardiovascular Diseases

Summary: the investigators prospectively recruited a total of 377 esrd patients evaluated for kidney transplantation between january 2010 and july 2013 in our centre. criteria for participation were a gfr below 20 ml/min/1.73m² or the need for haemodialysis and an age ≥18 years. 323 patients were on regular dialysis, the remaining 54 patients were being prepared for impending dialysis. patients with known ischemic heart disease were excluded from the study. all patients underwent a systematic analysis of cardiovascular risk factors based on structured interviews with a physician, health records, blood lipid levels, and routine mps at rest and under stress. in addition, 230 esrd patients (61%) received standardized dse. patients with signs of ischemia in mps and/or dse were evaluated for coronary angiography on clinical grounds.

end-stage renal disease (esrd) is a critical condition and bears a high risk of cardiovascular events. however, clinical algorithms to identify patients with coronary vasculopathies are still not defined and standardized. non-invasive imaging by myocardial perfusion scintigraphy (mps) or dobutamine stress echocardiography (dse) might be used in such patients, however, it is unclear if these provide complementary or identical information and how this correlates to coronary angiography. a direct comparison of these imaging approaches, excellently validated in coronary artery disease, has not yet been described in well-defined and large groups of esrd patients. the investigators therefore initiated a large prospective trial with 377 highly-selected and well-characterized end-stage renal disease patients without known coronary artery disease comparing the performance of standardized mps and dse. for the first time we here describe a significantly large proportion of esrd patients with contradictory findings in mps and dse and its correlation to invasive coronary angiography hinting to complementary rather than identical information between both modalities. this is an excellent basis of future studies comparing the prognostic value of mps versus dse versus a combined mps/dse approach.

Eligibility criteria:
inclusion criteria: * gfr below 20 ml/min/1.73m² exclusion criteria: * children * pregnant