Kornimate/medical-research-clean huggingface dataset:
the evaluation of left ventricular systolic function in different types of ischemic heart disease

Conditions: Coronary Microvascular Dysfunction; Obstructive Coronary Heart Disease

Summary: the study was designed to evaluate the left ventricular longitudinal strain and strain rate assessed by 2d-sti in patients with coronary microvascular dysfunction (cmd) or obstructive coronary artery disease (cad) , to investigate the effect of different types of ischemic heart disease on the lv systolic function, and to explore the value of ls on the diagnosis of coronary microvascular dysfunction.

a total of 175 patients with chest pain, without wall motion abnormality and without significant coronary artery stenosis (\ 2.5, n=108). at the same time, 67 age-matched patients with any major coronary arteries stenosis≥50% and without wall motion abnormality were involved into the obstructive coronary artery disease group. parameters of global longitudinal strain (ls) and strain rate, subendocardial ls and subepicardial ls were quantified by 2d-sti, the differences of these parameters among three groups were analyzed，correlation analysis、univariate and multivariate analysis and receiver operating characteristic curve were used.

Eligibility criteria:
inclusion criteria: * age from 18-85 years exclusion criteria: * patients with history of myocardial infarction or abnormal wall motion suggested by conventional echocardiography * patients with acute heart failure, chronic heart failure or lvef values less than 50% * patients with congenital heart disease, severe valvular disease, severe bradycardia, high atrioventricular block and atrial fibrillation * patients who did not store ultrasound images or whose ultrasound images were unclear * patients who had incomplete clinical data

Keywords: two-dimensional speckle tracking imaging strain coronary microvascular dysfunction
evaluation of post-ercp pain as a predictor for post-ercp pancreatitis

Conditions: Post-ERCP Acute Pancreatitis

Summary: pancreatitis is the most common complication after ercp, although its frequency varies significantly depending on the study from \< 2% up to 40%. based upon data from studies that have included unselected patients, post-ercp pancreatitis (pep) is mild, moderate, and severe in 45%, 44%, and 11% of cases, respectively. dysfunction of the sphincter oddi, female gender, younger age, previous history of pancreatitis, prolonged procedure time and pancreatic guidewire passages are well-known independent risk factors for pep. this study will assess whether the development of pep can be predicted by visual analogue scale (vas) level 1 hour after ercp.


Eligibility criteria:
inclusion criteria: * age \>18 years * scheduled for ercp for any reason exclusion criteria: * absence of consent * language barrier * no endoscopic advance to the papilla vateri * active pancreatitis at the time of the procedure * mental disability
a study of different use regimens using two acne treatments

Conditions: Acne Vulgaris

Summary: a study to determine if using 2 acne products in the morning is as safe and efficacious as using one product in the morning and one product in the evening.

approximately 240 subjects will be enrolled in this randomized, multi-center study. following satisfaction of entry criteria and screening procedures, all subjects will receive retin-a micro pump 0.04% and a 5% benzoyl peroxide wash (otc) for the entire 12-week treatment period. subjects will be randomized to either both morning treatments (test) or to the morning/evening treatment (active control). subjects will be assessed at baseline, at week 3, week 6 and again at the end of therapy, week 12 for number and type of individual lesions and safety. at selected sites, photographs will be taken at the same time points. at week 12 subjects will be assessed for investigator's global assessment of acne severity. the investigator will conduct all of the lesion counts, global assessments and safety assessments.

Eligibility criteria:
inclusion criteria: * males and non-pregnant or non-nursing females, 12 years or older, with facial acne vulgaris; * minimum of 20 but no more than 50 inflammatory lesions (papules and pustules); * minimum of 30 but no more than 100 facial non-inflammatory lesions (open and closed comedones); * must have at least a rating of grade 3 on the investigator global severity scale at baseline exclusion criteria: * known sensitivity to any of the ingredients in the study medication; * any nodulocystic acne lesions; * use of acne devices or systemic therapy with antibiotics within two months prior to start and throughout the duration of the study; * use of systemic therapy with retinoids within four months prior to study start and throughout the duration of the study; * topical use of retinoids within two weeks prior to study start and throughout the duration of the study; * topical use of antibiotics, steroids and/or other non-retinoid topical acne products within two weeks prior to study start and throughout the duration of the study; * if subject is taking birth control pills, she must be stabilized for at least three months prior to study start; * history of evidence of other skin conditions or diseases that may require concurrent therapy or may interfere with the evaluation of the study medication; * any significant medical conditions that could confound the interpretation of the study; * excessive facial hair that may interfere with evaluations; * no use of tanning booths, sun lamps, etc.

Keywords: acne irritation objective sensory methods
to compare the effectiveness of thulium fiber laser and holmium yag laser for ureteroscopic lithotripsy

Conditions: Ureteric Stone

Summary: this prospective randomized clinical trial aimed to compare the difference in stone ablation rates of tfl and ho:yag laser in a clinical setting. patients are randomized to receive urs with lithotripsy (ursl) either with tfl or ho:yag with an allocation ratio of 1:1. primary outcome is the efficiency of stone ablation in terms of the stone ablation rate

having the advantages of being minimally invasive and simple, ureteroscopic lithotripsy is one of the treatment options for ureteric stone less than 1.5 cm. while many energy systems has been used for stone fragmentation during ureteroscopy, laser energy is the most commonly used approach for stone fragmentation. currently, holmium-yag laser is the main laser platform being used due to its preciseness and safety. unfortunately, holmium-yag laser system has some intrinsic problems, such as lower energy conversion ratio, excessive heat generation in machines, noise etc. therefore, newer laser systems are being developed to overcome the problem. thulium-fiber laser (tfl) is the latest available laser system in the market with promising results. the advantages of tfl included better energy conversion ratio, less heat energy generation, more portable size, allow the generation of higher laser frequency for better stone dusting etc. therefore, its uses are increasing popular. however, there are not many studies comparing the efficacy and stone free results of the holmium-yag laser and tfl systems in the literature. therefore, investigators would like to perform a formal study to compare the two systems. .

Eligibility criteria:
inclusion criteria: * patients older than 18-years-old with informed consent exclusion criteria: * patients on anti-coagulation * patients with condition that increases the risk of urolithiasis (e.g. cystinuria, hyperparathyroidism, previous intestinal resection) * patients with abnormal urinary tract (e.g. ileal conduit, neobladder, ureteric stricture) * patients with stones \> 15 mm
neurologic deficits and recovery in chronic subdural hematoma

Conditions: Chronic Subdural Hematoma

Summary: chronic subdural hematoma (csdh) is one of the most common problems treated by neurosurgeons, particularly as the population ages. while often dismissed as a benign problem, it has become clear that csdh is associated with worse long term functional and cognitive outcomes compared to matched controls. though surgical techniques for treatment of csdh are becoming more effective and safe, a persisting problem of fluctuating, stroke-like neurological deficits has re-emerged. such deficits are not always directly related to hematoma mass effect and not always relieved with surgical decompression, but can result in prolonged hospital course, additional workup, and sometimes even additional invasive treatments. while the cause of such events is unknown, we recently documented for the first time that massive waves of spreading depolarization can occur in these patients and were closely linked to such neurologic deficits in some patients. in the current study, we plan to expand on these preliminary findings with rigorous, standardized application of post operative subdural electrocorticography monitoring, pioneered at our institution to detect sd. we also plan to build on our large retrospective analysis estimating the overall incidence of such deficits in csdh patients by assessing multiple proposed risk factors for sd. in addition, for the first time, we will assess the short- and long-term consequences of csdh and sd with detailed functional, cognitive, and headache related outcome measurement. these assessments are based on several remarkable cases we have observed with time-locked neurologic deterioration associated with recurrent sd. this study qualifies as a mechanistic clinical trial in that we will be prospectively assigning patients to the intervention of sd monitoring and assessing outcomes related to the occurrence of sd. this constitutes the application of a novel measure of brain signaling and assessing biomarkers of these physiologic processes of sd. these studies will provide critically needed information on this novel mechanism for neurologic deficits and worse outcomes after csdh evacuation. upon successful completion, we would identify a targetable mechanism for poor outcomes that occur commonly in patients with csdh. this overall strategy offers the opportunity to radically improve the care of patients with csdh by focusing on clinical trials of pharmacologic therapies for neurologic deficits in patients with csdh.


Eligibility criteria:
inclusion criteria: * chronic/ subacute subdural hematoma deemed necessary for surgical evacuation, * ability to consent or have lar consent exclusion criteria: * emergent need for evacuation, * acute traumatic subdural hematoma, and * severe baseline disability (mrs\>2) (modified rankin scale)
a single-dose study in paediatric patients aged 2 to less than 18 years with secondary hyperparathyroidism (shpt) receiving haemodialysis

Conditions: Chronic Kidney Disease, Secondary Hyperparathyroidism

Summary: this is a study to evaluate the safety and pharmacokinetics in pediatric patients with secondary hyperparathyroidism receiving a single dose of etelcalcetide at the end of hemodialysis.


Eligibility criteria:
inclusion criteria: * subject's parent has provided informed consent and subject has provided assent * children age 2 to less than 18 years * diagnosed with chronic kidney disease * diagnosed with secondary hyperparathyroidism receiving hemodialysis, * weighing at least 7 kg * laboratory results within specified range. exclusion criteria: * currently receiving treatment in another investigation device or drug study * subject has received cinacalcet therapy within 30 days * history of prolongation qt interval * subject is taking any medications that are on the qt prolongation medication list * electrocardiograph (ecg) measurements within specified range.

Keywords: secondary hyperparathyroidism, chronic kidney disease, hemodialysis
therapeutic education for multiple system atrophy (msa) patients and their caregivers

Conditions: Multiple System Atrophy

Summary: multiple system atrophy (msa) is a rare neurodegenerative disorder that leads to major disability, forcing patients and caregivers to adapt their environment and lifestyle. once they receive the diagnosis, patients and caregivers need to understand the symptoms, cope with them, to digest the diagnosis... all these needs are not completely addressed by the current model of care so we created a therapeutic educational program (tep) program that will last 12 months, involving both patients and caregivers, including a mixed model of in-person visits and continuous on-line activities. our project aims to target early msa patients and their caregivers, proposing to test the feasibility (primary objective) of an innovative therapeutic educational program (tep) for msa patients.

the announcement of msa diagnosis may provoke a shock in patients and their relatives. educational programs in neurodegenerative diseases, such as parkinson's disease (pd), offer patients and caregivers structured skills in disease knowledge, expertise, and management. those programs may result in an improvement of patients' quality of life (qol), empowering patients and their caregivers to deal with psychosocial challenges. additionally, it has been shown that educational programs positively impact the perceived health of pd patients without increasing medical costs. there is no educational program for msa patients. this is the reason why we created the first therapeutic educational program (tep) for msa patients and caregivers, including a mix model of in person visits and online classes and virtual activities. herein, we aim to target early msa patients (time to diagnosis \< 1 year) and their caregivers, proposing to test the feasibility of this tep. the program will last 12 months, involving both patients and caregivers, including a mixed model of in-person visits (at baseline and 12 months) and continuous on-line activities (learning situations, questionnaires, quizzes, videos, and interactive exercises).

Eligibility criteria:
inclusion criteria: * patients who have had a clinically probable diagnosis of msa within the last 3 years or clinically established within the last year * presence of a caregiver defined as a spouse, son/daughter or relative who lives with or sees the patient on a regular basis, i.e. at least three times a week. exclusion criteria: * patients and/or caregiver unable to give consent * patients without access to an internet network or without the material means to access the distance learning modules * patients with a life expectancy of less than one year * patients with legal guardians, curators, or legal protection * patients not affiliated to a social security system * patients in a period of exclusion from another study

Keywords: therapeuticeducationprogram feasibility
comparison of the application in traumatic brain edema between eit and non-invasive icp monitoring

Conditions: Brain Electrical Impedance;; Non-invasive Intracranial Pressure

Summary: brain edema is the main reason for the disability and lethality in traumatic brain injury, which is the most difficult part of emergency rescue. recently, there is no medical equipment to monitor the early brain edema in clinic. we have found that electrical impedance tomography (eit) can perform the real-time and bedside monitoring of brain electrical impedance after single-dose mannitol treatment, which may be a new strategy for the surveillance of brain edema. in this study, we would like to compare the application in traumatic brain edema between eit and noninvasive intracranial pressure (icp) monitoring, including the progress of brain edema, the relationship between impedance and icp, and the improvement for the patients' prognosis. eit would probably be a new image strategy for the treatment of traumatic brain injury.


Eligibility criteria:
inclusion criteria: 1. eligible patients were 16 to 65 years of age with all genders. 2. the patients had been diagnosed as traumatic brain injury during 24 hours before enrollment, with the confirmation of ct or mri. 3. all the patients had provided written informed consent. 6. the patients were receiving usual inpatient rehabilitation and conservative treatment . exclusion criteria: 1. the patients with indication of operation during the research should be excluded. 2. the patients were assessed as unqualified for the study according to the comprehensive evaluation opinion brought forward by the research team.

Keywords: brain electrical impedance; traumatic brain injury; brain edema; intracranial pressure
anesthesia for pars plana vitrectomy (ppv) with insulin needle

Conditions: Retinal Disorders

Summary: periocular blockade with 12.5 mm needle is as effective as block with 25 mm needle for patients undergoing pars plana vitrectomy.

the author wants to see the effect of short needle in patients undergoing retinal surgery.

Eligibility criteria:
inclusion criteria: * adult patients undergoing pars plana vitrectomy under local anesthesia exclusion criteria: * patients allergic to local anesthetic solutions * with local sepsis * serious impairment of coagulation * orbital abnormalities * unable to cooperate in maintaining a relatively motionless supine position * who refused the anesthetic technique

Keywords: efficiency pars plana vitrectomy
use of virtual reality goggles during chemotherapy infusion to reduce anxiety-related symptoms

Conditions: Hematopoietic and Lymphoid System Neoplasm; Malignant Breast Neoplasm; Malignant Head and Neck Neoplasm; Malignant Solid Neoplasm; Malignant Thoracic Neoplasm

Summary: this clinical trial evaluates the use of virtual reality (vr) goggles during chemotherapy infusion to reduce anxiety-related symptoms in patients with head and neck, thoracic, hematologic, and breast cancers. virtual reality headsets provide the ability for users to explore a simulated, three-dimensional environment with which users can interact. in virtual reality users can play interactive games, enjoy relaxing experiences, and watch immersive videos. the use of vr goggles may help with anxiety management during chemotherapy infusion.

primary objective: i. to evaluate the effectiveness of vr therapy in reducing severity of anxiety symptoms during chemotherapy infusion, compared to participants utilizing a smartphone as a control. secondary objectives: i. to evaluate whether there is a short-term effect of vr use in anxiety levels. ii. to assess participant satisfaction with their chemotherapy infusion experience in the control and treatment groups. exploratory objective: i. to assess participants' reported adverse effects associated with vr headset use. outline: patients are randomized to 1 of 2 groups. group 1: patients use vr during chemotherapy infusion on study. group 2: patients use smartphone during chemotherapy infusion on study.

Eligibility criteria:
inclusion criteria: * english speaking: ability to interact with virtual reality content may be impacted by inability to understand english; moreover, paper questionnaires will only be provided in english. * older than 18 years of age, and younger than 89 years of age. all sexes/gender identities and members of all races and ethnic groups will be included. * planned to receive chemotherapy infusion for head and neck, breast, thoracic, and hematologic cancers at the oregon health \& science university (ohsu) south waterfront center for health \& healing building 2 (there are no restrictions related to prior chemotherapy infusions or other cancer treatments). * chemotherapy treatment lasting at least 10 minutes. * ability to understand and willingness to sign a written informed consent document. exclusion criteria: * social or psychiatric conditions that may interfere with compliance. * reconstruction, incisions, wounds, wound care, or injury that impact the ability to place on the vr headset. this would limit the ability to utilize the vr headset. * history of seizure or epilepsy. * history of vertigo or persistent dizziness. * use of cardiac pacemaker, requirement for hearing aid on at all times, or have defibrillators. * children. * pregnant women. * decisionally impaired adults. * prisoners.
effectiveness of suprascapular nerve block in arthroscopic shoulder surgery

Conditions: Rotator Cuff Tear; Pain

Summary: most arthroscopic surgeries of the shoulder are currently performed as an outpatient. the postoperative analgesia should be optimal. general anesthesia allows for any arthroscopic surgery but does not provide a satisfactory postoperative analgesia . the locoregional anesthesia is recommended and includes several techniques: the interscalene nerve block, the suprascapular nerve block, intra-articular injection of local anesthetic and subacromial infiltration. the interscalene nerve block is currently the gold standard for anesthesia and postoperative analgesia for arthroscopic shoulder surgery with a success rate above 80% . however it must be carried out by teams experienced in the locoregional anesthesia because it is operator -dependent. the suprascapular nerve block is a simple technique that can be performed by the surgeon after surgery , effective in arthroscopic shoulder surgery , less invasive than the interscalene nerve block and exposing the patient to fewer complications. however, his interest was not assessed in the repair of tendons of the rotator cuff. the main hypothesis of this study is that the suprascapular nerve block is as effective as the interscalene nerve block in the prevention of early postoperative pain after arthroscopic repair of the infra and / or the supraspinatus rotator cuff tendons, without increasing the analgesic consumption while reducing the risk of complications related to regional anesthesia.


Eligibility criteria:
inclusion criteria: * aged over 18 years * arthroscopic repair of infra and / or supraspinatus tendon of the rotator cuff with or without associated procedure on the biceps, the acromion-clavicular joint or acromion * informed consent exclusion criteria: * allergy to local anesthetics (ropivacaine, bupivacaine, xylocaine) * previous surgery on the involved shoulder * severe or morbid obesity (bmi\> 35) * psychiatric disorders (impossible self-assessment of the pain) * patient unfit physically, mentally or legally to give informed consent * patient refusal * pregnant or lactating women

Keywords: suprascapular nerve block interscalene nerve block
trajectories and mechanisms of recovery from malaria: an observational study

Conditions: Malaria

Summary: this observational research study aims to answer the question: 'which aspects of human biology play an important role in recovery from symptomatic malaria?' in particular, the researchers aim to identify human genes for which the level of gene activity reflects the patient's overall rate of recovery. the researchers believe this approach may reveal new targets for adjunctive therapies. the researchers aim to recruit 240 people, of all ages, who have been diagnosed with symptomatic malaria at selected hospitals in london. blood samples, urine samples, and clinical information will be collected over the 14 days following malaria diagnosis.


Eligibility criteria:
inclusion criteria: patients of any age with symptomatic malaria confirmed by asexual stage parasitaemia (of any plasmodium species) on blood film. exclusion criteria: patients with asymptomatic malaria; patients with congenital malaria; patients with plasmodium gametocytaemia only; patients with known hiv; patients who have received antimalarial treatment for symptomatic malaria in the 28 days prior to hospital presentation; patients who explicitly deny consent.

Keywords: malaria recovery transcriptomics