Kornimate/medical-research-clean huggingface dataset:
duration of platelet inhibition by aspirin

Conditions: Coronary Artery Disease

Summary: the well established importance of regular aspirin administration stands on firm grounds, as large meta-analyses have shown this therapy to significantly reduce the risk of death. however, not all patients benefit of aspirin administration to the same extent, thus high-lighting a sub-population of patients with inadequate platelet response to asa. the mechanisms underlying reduced asa efficacy remain elusive. a recent report has suggested that platelets, long believed to be incapable of de novo protein synthesis, may retain their ability to form the cyclooxygenase enzyme, once it has been inactivated by aspirin. this may explain the inefficacy of the drug to induce sustained platelet inhibition in certain patients. the current study aims to evaluate, in patients suffering from stable coronary artery disease, the stability of platelet inhibition by aspirin during the normal once daily dosing regimen.


Eligibility criteria:
inclusion criteria: * patients suffering from stable cad, on chronic asa therapy * patients willing to participate in the study and to sign the informed consent form exclusion criteria: * acute coronary syndrome or revascularization in the last 3 months prior to enrolment * concurrent ingestion of nonsteroidal anti-inflammatory drugs (nsaids, including cox-2 selective anti-inflammatory drugs), clopidogrel, ticlopidine, dipyridamole, warfarin or acenocoumarol * frequent use (more than once a week) of non-prescription nsaids or drugs containing asa in the 10 days preceding enrolment * major surgical procedure within 1 month before enrolment * hemorrhagic diathesis or known platelet dysfunction * platelet count outside the 100 to 450 x109/l range for technical reasons * hematocrit \< 25% or haemoglobin \< 100 g/l * patient undergoing dialysis for chronic renal failure * patient found to be asa resistant

Keywords: platelet aggregation aspirin
clear aligner treatment with and without low level laser therapy for upper incisor crowding

Conditions: Crowding of Anterior Maxillary Teeth

Summary: the goal of this clinical trial is to assess the effect of low level laser therapy (lllt) on upper incisor crowding using clear aligner treatment (cat).

the goal of this clinical trial is to assess the effect of low level laser therapy (lllt) on upper incisor crowding using clear aligner treatment (cat) on healthy patients (16-23 years old) with complete set of dentition and angle class i. the main questions to answer are: 1. evaluate rate of upper incisor decrowding using cat and lllt 2. does lllt affect pain during cat? researchers will compare cat with lllt to cat without lllt to see if the lllt will accelerate orthodontic tooth movement. participants will: * change to a new aligner every 7 days. * visit the clinic every week for checkup. * log in pain scores every 6, 24, 48 and 72 hours after delivery of new aligners.

Eligibility criteria:
inclusion criteria: 1. patients age ranging from 16-23 years old with angle class i malocclusion and upper anterior crowding. 2. healthy, compliant and internally motivated patient. 3. full set of maxillary permanent dentition except third molar. exclusion criteria: 1. previous orthodontic treatment. 2. any systemic diseases that could interfere with orthodontic treatment. 3. gross gingival or periodontal problems

Keywords: clear aligner treatment low level laser therapy clear aligner therapy accelerated orthodontics orthodontic tooth movement upper incisor crowding orthodontic pain
riat registry: reason for not intensifying antihypertensive treatment

Conditions: Hypertension

Summary: to support physicians in their active management of hypertensive patients. by targeting specific systolic and diastolic blood pressure (bp) figures physicians will closely monitor the bp values and as such will have an individualized control of the treatment in each patient.


Eligibility criteria:
the following information on clinical trials is provided for information purposes only to allow patients and physicians to have an initial discussion about the trial. this information is not intended to be complete information about the trial, to contain all considerations that may be relevant to potential participation in the trial, or to replace the advice of a personal physician or health professional. main criteria are listed hereafter: inclusion criteria: * adult hypertensive * either newly diagnosed and untreated * or previously treated and uncontrolled patients of both sexes with essential hypertension exclusion criteria: * known secondary hypertension * known secondary curable hypertension (i.e. pheochromocytoma, aldosterone producing adenoma, cushing disease). patients with renal disease are not excluded.
post-authorisation safety study (pass) of influenza vaccine in united kingdom (uk)

Conditions: Influenza

Summary: the purpose of this study is to conduct a pilot study to explore the potential use of routinely collected data in general practitioner (gp) practices to conduct enhanced safety surveillance of seasonal influenza vaccines in the uk, as recommended in the ema interim guidance on enhanced safety surveillance for seasonal influenza vaccines in the eu.

data routinely collected as part of clinical consultations in primary care will be extracted from nine general practitioner (gp) practices in order to estimate medically attended adverse events of interest (aeis), for people who have received an influenza vaccine. this study will also actively follow patients who were exposed to seasonal influenza vaccination for 7 days in three of the nine gp practices using a customised card-based adverse drug reaction reporting system, in order to determine whether a more active approach to surveillance can capture higher rates of aeis.

Eligibility criteria:
inclusion criteria: * all individuals (aged 6 months and above) who will receive seasonal influenza vaccination in the 9 gp practices between 1 september 2015 and 30 november 2015. * pregnant women are also included in this study. exclusion criteria: • only registered patients who have explicitly opted out of data sharing will be excluded from the analysis.

Keywords: post-authorisation safety study (pass) adverse drug reaction reporting systems post marketing product surveillance european medicines agency (ema) influenza vaccine computerized medical record system united kingdom primary health care
a population-based prospective study of metastatic colorectal cancer (crc) patients in finland

Conditions: Metastatic Colorectal Cancer

Summary: * a population-based prospective study to evaluate clinical behaviour, resectability and survival in 1st line metastatic colorectal cancer (crc) patients in finland * primary objective: to assess clinical behaviour of metastatic colorectal cancer and overall resectability, postoperative morbidity and outcomes after resection * secondary objectives: to assess treatments for mcrc; to assess efficacy of chemotherapy and targeted drugs with overall response rates (orr), failure free survival (ffs), progression free survival (pfs), and overall survival (os); to radiologically assess tumour density and morphology, and assess alternative radiologic response evaluation in comparison with recist response criteria; to evaluate whole blood, plasma, serum and tumour block biomarkers and dna polymorphisms that may predict drug effects, resectability and clinical behaviour of the tumour


Eligibility criteria:
inclusion criteria: 1. patients with histologically confirmed crc, who are scheduled to start or are getting first line chemotherapy for metastatic disease 2. age \> 18 3. metastatic disease (including locally advanced disease not amenable with surgery and/or (chemo)radiotherapy) 4. signed written informed consent according to ich/gcp and the local regulations (approved by the independent ethics committee \[iec\]) will be obtained prior to study 5. no informed consent will be obtained from patients participating in the data collection study obtaining data from hospital charts. no blood sampling, nor contacting of patients will be performed.

Keywords: metastatic colorectal cancer
early prediction of hypocalcaemia following thyroid surgery

Conditions: Hypocalcemia

Summary: 150 patients divided into two groups.the experimental group was submitted at the assay of ipth six hours after surgery whilst the control group was submitted to a daily assay of serum calcium and phosphorus.

purpose: the aim of this randomized controlled trial was to validate the results of a previous prospective cohort study conducted in the same surgical unit regarding the use of concomitant intact parathyroid hormone (ipth) and serum calcium measurement in predicting hypocalcemia after total thyroidectomy. methods: from january 2014 to january 2015, 150 patients underwent total thyroidectomy in our department and were divided into two groups. the experimental group was submitted at the assay of ipth six hours after surgery whilst the control group was submitted to a daily assay of serum calcium and phosphorus. sensitivity and specificity of different serum measurements have been calculated using the receiver-operator characteristics (roc) curve.

Eligibility criteria:
inclusion criteria: * be submitted to total thyroidectomy during the study period * have signed the informed consent exclusion criteria: * lack of inclusion criteria * lobectomy with isthmusectomy or partial or subtotal thyroidectomy * completion thyroidectomy * concomitant hyperparathyroidism was present * concomitant treatment with oral calcium and/or vitamin d prior to surgery
novel mri for diagnosing traumatic brachial plexus injuries

Conditions: Brain Injuries

Summary: the aims are: 1. investigate new magnetic resonance imaging (mri) scans for diagnosing severe nerve injury in the arm. 2. understand how the brain and spinal cord respond to severe nerve injury using mri. the nerves which control movement and feeling in the arm can be severely damaged in eg. motorbike crashes, sporting or work-related injuries. every year 500 adults sustain life-changing major nerve injuries, causing 1) disability needing constant care, 2) life-long pain and 3) mental illness. in england, major nerve injuries cost £250million every year in hospital treatments, unemployment and social care. injured nerves can be repaired with surgery. to decide if nerves need repairing, exploratory surgery is needed. instead, we have developed a new mri scan which could diagnose nerve injuries, meaning that exploratory surgery could be avoided, nerve injuries could be diagnosed sooner and reconstructive surgery performed sooner. some people with nerve injuries develop lifelong pain - if we could understand how the brain adapts, we could learn how to prevent nerve pain. also, some people don't recover movement in their hand - if we could understand how the brain reorganises nerves controlling movement, we could predict who would benefit from surgery.


Eligibility criteria:
inclusion criteria: adults with traumatic bpis who require surgical exploration of the supraclavicular brachial plexus. a traumatic bpi is defined by the absence of any or all motor or sensory function in an upper limb, following trauma. exclusion criteria: * patients with an acutely ischaemic limb as they require immediate surgical intervention * unable to get into the mri scanner due to habitus or claustrophobia * unable to lie still due to any cause (eg. athetoid movements, dystonias, chorea, etc) * intraocular or intracranial metallic foreign bodies * active implants (eg. pacemakers, implantable cardiac defibrillators, nerve stimulators, etc) which are not mri safe or conditional. * pregnancy - whilst there are no known adverse effects of mri(129-131) to the mother or fetus, mri is generally avoided in pregnancy due to the acoustic trauma(132) and inductive heating generated by alternating magnetic fields. * any pre-existing neurological disorder, injury or disease causing a functional impairment in the affected limb * patients lacking capacity to consent
efficacy of the erchonia corporation thl™ for providing relief of tinnitus symptoms

Conditions: Tinnitus

Summary: the purpose of this clinical study is to determine the effectiveness of the erchonia® thl™, manufactured by erchonia corporation (the company), for prescription home use in providing relief of tinnitus symptoms when used by individuals in their own homes.

human factors validation testing will initially be conducted to valuate a lay person's ability to understand and apply as applicable the information contained in the thl™ use device proper use reference guide, and device packaging and labeling materials to correctly, safely, and successfully activate and operate the thl™ to administer the treatment; and to identify any and all use difficulties, problems and errors, including those pertaining to critical tasks and close calls demonstrated by the lay person during device operation, and to subsequently mitigate each identified instance of use error through device and/or materials modification, and to subsequently evaluate the effectiveness of each modification, as applicable phase two will commence following the successful completion of phase one. phase two comprises the performance of a double-blind, randomized, placebo-controlled, clinical study of the efficacy of the erchonia® thl™, manufactured by erchonia corporation (the sponsor), for prescription home use application in providing relief of tinnitus symptoms when used by individuals in their own homes.

Eligibility criteria:
inclusion criteria: * bilateral tinnitus * current diagnosis of subjective tinnitus * no hearing loss or sensorineural hearing loss only * 18 years of age or older * able to read and write english * constant tinnitus on-going over at least the past 6 months * willing to abstain from other tinnitus-related treatments, except existing hearing aid use, throughout the study duration. * tinnitus functional index (tfi) total score of 32 to 72 (moderate to big problem) * degree of hearing loss is less than 60 db (moderate or less) exclusion criteria: * tympanosclerosis * meniere's disease * acoustic neuromas * current and consistent use of ototoxic medications * presbycusis * thyroid disease * skull fracture * traumatic brain injury (tbi) * depression * syphilis * retrocochlear tumors * conductive hearing loss * pregnant, think they might be pregnant, or breastfeeding. * open wounds (sores, cuts, ulcers, etc) around ears or neck * cancerous growths around ears or neck * difficulty with hand dexterity sufficient to impact the ability to administer treatments with the laser such as from severe arthritis in the hands, multiple sclerosis, -cerebral palsy, parkinson's disease, huntington's disease, etc.
the advise study: advanced visualization in corneal surgery evaluation

Conditions: Fuchs Dystrophy; Endothelial Corneal Dystrophy; Bullous Keratopathy; Vision Disorders

Summary: rationale: intra-operative optical coherence tomography (ioct) is a new technology that incorporates advanced imaging techniques in the ophthalmic operating theatre. this allows surgeons to visualize tissues in a way previously impossible we conceptualized an ioct-guided surgical protocol for the treatment of endothelial cell dysfunction, that refrains from the current practice of over-pressurizing the eye at the end of surgery. objective: the aim of this study is to assess the clinical value of intraoperative oct (ioct) for descemet membrane endothelial keratoplasty (dmek) by comparing an ioct-optimized surgical protocol with current practice, where the eye is over-pressurized for a set period of time, in terms of surgical efficiency, clinical outcomes, and adverse events. study design: international multicentre non-inferiority randomized clinical trial study population: patients scheduled for posterior lamellar corneal surgery for endothelial cell dysfunction above the age of 18 years. intervention: both groups will undergo descemet membrane endothelial keratoplasty. patients will be randomized for either the ioct optimized surgical protocol or current standard surgical protocol using 8 minutes of overpressure to facilitate graft adherence. both groups will be evaluated with ioct at the end of surgery. main study parameters/endpoints: the main study parameter is the rate of adverse events (particularly graft dislocations). secondary parameters/endpoints are surgical time, the recovery of visual acuity and endothelial graft quality at 3 and 6 months follow-up, and a detailed evaluation of the extent/duration of surgical tissue manipulations. nature and extent of the burden and risks associated with participation, benefit and group relatedness: the use of ioct during surgery does not entail additional risk to the patient. participants to this study will adhere to the standard of care after corneal transplant surgery. in addition, they will receive study specific measurements and questionnaires. the additional measurements and questionnaires will be combined with regular follow up moments.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * irreversible corneal decompensation caused by fuchs corneal endothelial dystrophy or pseudophakic bullous keratopathy * eligible for posterior lamellar keratoplasty, specifically descemet membrane endothelial keratoplasty (dmek) exclusion criteria: * any ocular co-morbidity other than cataract, mild dry eye disease, ocular hypertension, simple primary open angle glaucoma, and mild age-related macular degeneration * prior corneal transplant surgery * human leukocyte antigen (hla) matched keratoplasty * any disability that will interfere with performing or understanding the procedures and questionnaire fulfilment except if it is temporary of nature. * combined phaco-emulsification-dmek surgery (triple procedure)
interrupting self-harm study

Conditions: Nonsuicidal Self-injury

Summary: my study will employ a convergent mixed methods two-arm parallel randomized controlled design. the qualitative strand will primarily rely on semi-structured interview procedures to answer the following questions: (1) how do adolescents perceive and experience the phenomenon of nonsuicidal self-injury (nssi)? (2) what do adolescents believe needs to be done to address nssi? the quantitative strand will primarily rely on clinical interview data, self-report measures, and an experimental task protocol to answer the following question: what is the impact of a brief mindfulness induction (versus a control condition) on self-injury attentional bias among self-injuring adolescents?


Eligibility criteria:
inclusion criteria: * to be included in the study, a participant must be: 1) at least 12 years old and no more than 18 years old, 2) able to understand and communicate in english, 3) willing and able to participate in all study procedures, and 4) currently engaging in nonsuicidal self-injury or have a history of nonsuicidal self-injury. exclusion criteria: * individuals will be excluded from the study if they are experiencing a suicidal crisis at the time of the study procedures (e.g., they endorse suicidal ideation, planning, and intent as determined by the mini international neuropsychiatric interview 7.0) and require crisis intervention or hospitalization.
evaluation of a cardiac coherence session to reducing patients' anxiety during a mri examination

Conditions: Anxiety

Summary: the present project aims at conducting a proof of concept study to explore the pertinence of a single session of cardiac coherence, carried out in patients prior to an mri examination and presenting anxiety in relation to this examination, to reduce their level of anxiety and thus improve the course of the examination.

although magnetic resonance imaging (mri) is considered to be biologically safe and painless, the examination is often perceived by patients as difficult to bear, causing a great deal of anxiety due to the various constraints: the upper half of the body, including the head, positioned in a tube with a circumference of approximately 70 cm, relatively long duration, immobilization and even restraint. however, all these conditions are necessary to obtain good quality images, which are essential for the interpretation of the examination for diagnostic purposes by the clinicians. the anxiety of patients linked to the performance of an mri examination and its negative effects are documented in the literature. according to some authors, 71% of the professionals surveyed stated that anxiety was a common problem in their mri centre and 19% stated that it regularly disrupted the examination. it is estimated that 10% of the motion artefacts present on mri examinations are caused by anxiety-related motor agitation, making image quality difficult to exploit. thus, every day, many mri examinations are cancelled, interrupted, or of poor quality due to movement and difficult to interpret. all these examinations must therefore be rescheduled, with delays that can be several months long. among these non-drug methods, cardiac coherence seems promising. this method is recent, non-invasive, of short duration, very easy to implement and requires little training for users. the present study hypothesize that a single session of cardiac coherence, carried out in patients prior to an mri examination and presenting anxiety in relation to this examination, could make it possible to reduce their level of anxiety and thus improve the course of the examination.

Eligibility criteria:
inclusion criteria: * person affiliated to or benefiting from a social security scheme; * free, informed and written consent signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research); * patient to undergo an mri examination of the upper half of the body * patient over 18 years old * patient with a high level of anxiety (score ≥ 4) in relation to mri non-inclusion criteria: * patient under legal protection or under another protection regime (guardianship, curatorship). * sedated or unconscious patient * patient performing an emergency mri examination * patient with a level of french language that does not allow sufficient understanding for the completion of questionnaires exclusion criteria: - stai y-a score \< 46 (insignificant or low anxiety)

Keywords: cardiac coherence improving patient management