Kornimate/medical-research-clean huggingface dataset:
multidisciplinary evaluation of patients with hemophilia

Conditions: Haemophilia

Summary: multidisciplinary assessment of the physical, functional and psychosocial alterations in patients with hemophilia around the country. the aims of this study are: * descriptive study of joint involvement in hemophilia patients with and without a history of hemarthrosis. * descriptive study of the alterations of periarticular muscle strength as a result of acute processes or the development of chronic articular sequelae. * descriptive study of biomechanical changes in lower limb joints and their impact on gait in patients with hemophilia. * descriptive study of the joint space, regarding hemarthrosis and synovitis, intraarticular by ultrasonography. * descriptive study of the relationship between skeletal muscle pathology in patients with hemophilia and their perceptions of it and their quality of life.

observational study that will allow us: analyze and evaluate the skeletal muscle of patients with hemophilia involvement. describe the periarticular muscular deficit, depending on the degree of injury, age, presence of inhibitors and the development of physical activity. identify the relationship between the functional deficit by clinical assessment performed with the use of validated scales measure force production with patients. observe the presence of joint bleeds in children with hemophilia and synovial hypertrophy developing therein. detect biomechanical abnormalities of the lower limbs and their impact on gait in patients with hemophilia. assess the factors that influence the perception of illness and quality of life of patients with hemophilia.

Eligibility criteria:
inclusion criteria: * patients with hemophilia a and b. * patients of all ages (pediatric, adolescents, youth and adults). * with or without joint involvement clinically diagnosed, and with or without a previous history of hemarthrosis joint loading. * patients with or without inhibitors. exclusion criteria: * patients without prior walking capacity. * patients diagnosed with other congenital coagulopathy (von willebrand disease, etc..). * patients with neurological or cognitive impairments that prevent understanding the questionnaires and physical tests.

Keywords: haemophilia arthropathy range of motion strength proprioception gait quality of life.
a self-management intervention for youth with sickle cell disease and their families: phase i

Conditions: Anemia, Sickle Cell

Summary: this study is being conducted to test an intervention for children and adolescents ages 8-17 years with sickle cell disease and their families. in the first phase of this study, key informant interviews are being conducted with health care providers and children ages 8-17 with sickle cell disease and their primary caregivers. participants are asked to review the intervention and provide feedback that will inform revision to the intervention.

key informant, semi-structured interviews are conducted using an interview guide to obtain expert provider (healthcare providers of children with scd) and end-user (children and parents/caregivers) feedback on the intervention. interview questions are designed to solicit information on advantages and disadvantages, perceived usefulness, and recommendations for improvement on the intervention. the interviews will last approximately 1 hour and are audio recorded. recordings are transcribed for analysis. data are analyzed using a deductive-inductive approach with the intervention as a framework for initial categories. findings will inform revisions to the intervention. feasibility testing of the revised intervention will be conducted in the next phase of the study.

Eligibility criteria:
inclusion criteria: * children ages 8-17 years and their primary caregiver * child with scd as indicated by self/parent report or report from musc pediatric sickle cell clinic staff * child has been seen at the musc pediatric sickle cell clinic for at least 6 months * musc pediatric sickle cell clinic staff report preventive recommendations are followed by child/caregiver health care providers: * age 18 years or older * healthcare professional with at least 6 months' experience caring for children with scd exclusion criteria: * non-english speaking * inability or unwillingness to participate in a one-on-one interview * inability or unwillingness of parent/caregiver or health care provider to give informed consent and of child to give assent
a personalized telehealth intervention for health and weight loss in postpartum women

Conditions: Postpartum Weight Retention

Summary: the purpose of this study is to help women lose the weight they gained during their pregnancy using a smartphone app the investigators have developed called e-moms. the investigators hypothesize that the moms given the app to use during the study will lose more weight than the moms who do not use the app.

the e-moms study will last about 4 months. the weight management program is 4 months long and will end about 6 months after the participant's baby is born. all participants will receive women, infants and children (wic) services. for the weight management program, participants will be put into one of these groups: 1. wic moms: receive advice and services for nutrition and weight management after pregnancy from their wic clinic. 2. wic e-moms: receive a personalized diet and exercise plan to help them lose the weight they gained during their pregnancy. all information will be given to them using a smartphone, such as an iphone. they will also get advice and services from your wic clinic.

Eligibility criteria:
inclusion criteria: * are a female who has delivered a baby within the last 2 months * are 18 years of age or older * have a body mass index ≥25 kg/m2 or \<40 kg/m2 * are accepted for post-pregnancy wic services * are english-speaking exclusion criteria: * are participating in the nurse family partnership program * had multiples in your most recent pregnancy * are unwilling to be assigned at random to either of the 2 study groups * are planning to move out of the study area within the next 6 months * have a history of psychiatric conditions or chronic disease than can impact body weight, appetite, or energy intake such as hiv/aids, cancer, bipolar disorder or schizophrenia * currently use antipsychotic medications or have used such medications in the previous 12 months * have been diagnosis with type i diabetes * report having a heart attack, stroke, or being hospitalized or treated for chest pain * currently taking medications or supplements to aid in weight loss * have had weight loss surgery in the past year or plan to have it prior to study completion. * currently participating in another interventional study that influences weight control * currently abusing drugs or alcohol (up to 14 drinks per week allowed)

Keywords: pregnancy weight loss
a study of the effects of lavender aromatherapy on preoperative anxiety in breast surgery patients

Conditions: Anxiety

Summary: the purpose of this study is to determine the effects of lavender aromatherapy on preoperative anxiety by measuring changes in pulse rate and anxiety core using spielberger state-trait anxiety index questionnaires and on postoperative pain medicine usage. study participants will then be randomized into one of four groups; either they will receive 2 drops of lavender (lavandula angustifolia) oil (lo) or 2 drops of michelia alba leaf oil (ma) or 2 drops of unscented almond oil (ao) or two drops water on the inside of an oxygen face mask for 15 minutes. linalool makes up \~30% of lavandula angustifolia oil and is believed to be its most active anti-anxiety component. before and after treatment, anxiety level will be measured using the spielberger state-trait anxiety inventory.


Eligibility criteria:
inclusion criteria: * women, older than 18, american society of anesthesiologists (asa) classification i-iii, undergoing elective breast surgery on tisch 10th floor day surgery. cancer patients are included. exclusion criteria: * history of asthma, bronchitis, copd, contact dermatitis to cosmetic fragrances, positive patch test, pregnancy, and significant laboratory abnormalities.

Keywords: preoperative anxiety breast surgery lavender aromatherapy
diagnostic accuracy of body temperature measurement in geriatric patients

Conditions: Fever; Infection

Summary: retrospective analysis of a quality measurement project examining the quality of vital parameter measurement in consecutive patients \>= 75 years presenting to the emergency department. primary goal of the study is to evaluate the diagnostic accuracy of body temperature measurement using different methods to diagnose infection in patients \>= 75 years presenting to the emergency department. the secondary goal is to compare the reliability of tympanal and temporal artery thermometry with rectal temperature measurement.


Eligibility criteria:
inclusion criteria: * \>= 75 years * given informed consent exclusion criteria: * patients who do not speak the german language * patients with unstable cardiorespiratory status * presence of contraindications to one of the temperature measurement methods
local field potentials recorded from deep brain stimulating (dbs) electrodes

Conditions: Parkinson's Disease

Summary: this study will be recording and evaluating brain activity from deep brain stimulating (dbs) electrodes in patients with parkinson's disease.


Eligibility criteria:
inclusion criteria: * surgical candidate for dbs implantation.

Keywords: brain activity implanted with dbs electrodes
comparative study of ultrasound-guided paravertebral block versus intravenous tramadol in percutaneous nephrolithotomy

Conditions: Postoperative Pain

Summary: paravertebral block has been widely used for analgesia. the aim of this study,comparison of the effect of ultrasound-guided paravertebral block versus intravenous tramadol for postoperative pain control in percutaneous nephrolithotomy.

the study protocol was approved by the local ethical committee. written informed consent was obtained from all patients, before starting to surgery. the patients were given no premedication. the demographic data of patients (age, gender, the presence of other diseases) were recorded, preoperatively. all patients were applied standard monitoring in the operating room. after the induction of anesthesia provided intravenously propofol (2-3mg/kg) and rocuronium bromide (0.5 mgkg-1), all patients were intubated with a suitable endotracheal tube. anesthesia maintenance was provided with 1-2% sevoflurane and a 60% nitrous oxide-40% oxygen gas mixture. 0.9% nacl (5-10 mlkg-1) was started as fluid resuscitation. urinary catheter was inserted before placement, and then all patients were placed in the prone position. postoperatively, duration of surgery, systolic and diastolic blood pressures, heart rate, peripheral oxygen saturation (sbp, dbp, hr, and spo2), visual analog scales (vas), side effects such as vomiting and nausea, complications such as pneumothorax, tramadol consumption and additional analgesic requirements of patients were recorded at 1, 2, 4, 6, 12 and 24 h in the postoperative period. these parameters were evaluated by an anesthesiologist in the first 24 hours postoperatively. if the vas score was \>4, patients in both groups were administered diclofenac.

Eligibility criteria:
inclusion criteria: * 53 patients scheduled for percutaneous nephrolithotomy (pnl), * 18-70 years of age, * weight between 50-100 kg, * american society of anesthesiologists (asa) classification i-ii were included exclusion criteria: * the exclusion criteria were refusals by patients, * coagulation abnormalities, * patients with spinal deformity, * cutaneous infection at the injection site and * a known allergy to drugs.
nicotinamide-based supportive therapy in lymphopenia for patients with covid-19

Conditions: Covid19; Lymphopenia

Summary: the mechanism of peripheral blood lymphocyte decline in covid-19 patients is not yet clear. however, one theory demonstrated that in the whole progression of covid-19, the extensive activation of poly-adp-ribose polymerase (parp) may reduce the cellular nad+ and dampen the adaptive immune system. so investigators presume that replenishing the nad+ using nicotinamide as the precursor may improve the lymphocyte counts and boost the adaptive immune system. as a result, the study using nicotinamide as a kind of supportive therapy provide further evidence of their efficiency and safety in treating lymphopenia in patients with covid-19.


Eligibility criteria:
inclusion criteria: * the patients diagnosed as the common or severe cases of covid-19 * aged 18-85 * the absolute lymphocyte counts below the normal value (\<1.1-3.2×109/l) exclusion criteria: * the patients who are diagnosed as critically ill cases or participating in other clinical trials * women who are pregnant or lactating * alt/ast \> 5 times upper limit of normal (uln), neutrophils counts \< 0.5×109/l, platelets counts\< 50×109/l * patients diagnosed with rheumatoid immune-related diseases * patients who take long-term oral anti-rejection drugs or immunomodulatory drugs * hypersensitive reaction to nicotinamide or any auxiliary materials * patients with active tuberculosis or combined with bacterial and fungal infections * patients undergoing organ transplant * patients with mental disorders.

Keywords: nicotinamide covid19 lymphopenia
effect of treatment bi 1744 cl (5 and 10 mcg) versus placebo on exercise endurance time during constant work rate cycle ergometry i

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: to compare the effects of bi 1744 cl versus placebo on exercise tolerance after 6 weeks of treatment in patients with chronic obstructive pulmonary disease


Eligibility criteria:
inclusion criteria: 1. signed informed consent prior to participation. 2. diagnosis of chronic obstructive pulmonary disease and post-bronchodilator fev1(forced expiratory volume in 1 sec) \<80% of predicted normal and post-bronchodilator fev1(forced expiratory volume in 1 sec)/fvc of \< 70% at visit 1. 3. male or female between 40 and 75 years of age. 4. current or ex-smokers with smoking history of more than 10-pack years. 5. able to perform technically acceptable pulmonary function tests, multiple exercise tests and able to maintain records. 6. able to inhale medication in a competent manner from a metered-dose inhaler and respimat inhaler. exclusion criteria: 1. patients with clinically relevant abnormal baseline haematology, blood chemistry, or urinalysis; all patients with an sgot \>x2 uln, sgpt \>x2 uln, bilirubin \>x2 uln or creatinine \>x2 uln. 2. patients with a history of asthma and/or total blood eosinophil count of 600 cells/mm3. 3. patients with thyrotoxicosis, paroxysmal tachycardia (\>100 beats per minute). 4. patients with a history of myocardial infarction within 1 year of screening visit, unstable or life-threatening cardiac arrhythmia, hospitalization for heart failure within the past year, known active tuberculosis, a malignancy for which patient has undergone resection, radiation therapy or chemotherapy within last five years, life-threatening pulmonary obstruction, cystic fibrosis, clinically evident bronchiectasis, significant alcohol or drug abuse or contraindications to exercise. 5. patients who have undergone thoracotomy with pulmonary resection. 6. patients being treated with oral beta-adrenergics or oral corticosteroid medication at unstable doses (i.e., less than six weeks on a stable dose) or at doses in excess of the equivalent of 10 mg of prednisone per day or 20 mg every other day. 7. patients who regularly use daytime oxygen for more than one hour per day. 8. patients who have completed a pulmonary rehabilitation program in the six weeks prior to the screening visit or patients who are currently in a pulmonary rehabilitation program. 9. patients who have a limitation of exercise performance as a result of factors other than fatigue or exertional dyspnea. 10. pregnant or nursing women. 11. women of childbearing potential not using two effective methods of birth control (one barrier and one non-barrier).
the efficacy of cone beam computed tomography (cbct) compared to panoramic radiography prior to third molar removal

Conditions: Inferior Alveolar Nerve Injury

Summary: the purpose of this study is to evaluate the efficacy and cost-effectiveness of cone beam computed tomography (cbct) compared to panoramic radiography prior to removal of third molars in reducing patient's morbidity. adults having a close relationship between the mandibular canal and one or both lower third molars, as diagnosed from digital panoramic radiographs will be recruited for this randomised controlled trial. in one trial arm, patients will receive the standard digital panoramic radiograph prior to third molar surgery. in the second arm, subjects will undergo an additional cone beam computed tomography (cbct) prior to third molar surgery. all patients require a postoperative visit one week after surgery to assess the outcome.


Eligibility criteria:
inclusion criteria: * adults \>18 year * mandibular canal is superimposed more than one half by the roots of the third molar as assessed on panoramic radiograph. exclusion criteria: * pregnancy * radiological evidence of cyst an tumors * indication for removal under general anesthesia * preoperative neurosensory alterations * existence of an external cbct

Keywords: cbct third molar removal inferior alveolar nerve injury
white tea for prevention of chemotherapy induced mucositis

Conditions: Oral Mucositis

Summary: the aim of this study is to determine the effectiveness of mouthwash with white tea in the prevention of paclitaxel induced oral mucositis in women with breast cancer.

oral mucositis is a common side effect from paclitaxel treatment. it can be very painful and compromise nutrition and oral hygiene, and it may increase the risk of infection. although oral mucositis is a common side effect to chemotherapy, no available treatment is yet available that can effectively prevent or treat oral mucositis. based on the knowledge that white tea has anti-inflammatory, anti-oxidant and anti-microbial effect, the current study aims to assess the effect of mouth wash with white tea on paclitaxel induced oral mucositis in women with breast cancer. this study is a phase ii randomized controlled trial in which eligible patients will be allocated to a control group (cg) and a study group (sg). the cg will use salt water with soda for mouthwash eight to ten times a day and the sg will use white tea for mouthwash five to six times a day.

Eligibility criteria:
inclusion criteria: * woman with breast cancer * planned neoadjuvant or adjuvant paclitaxel treatment * age ≥ 18 years * understand and speak danish * written and orally informed consent exclusion criteria: - palliative treatment with paclitaxel

Keywords: mucositis mouth paclitaxel
feasibility, reliability, and satisfaction of cea using home based (automated) capillary blood sampling

Conditions: Colorectal Cancer

Summary: the goal of this study is to determine the feasibility of cea assessments at home using (automated) capillary sampling in patients in the follow-up after treatment for colorectal cancer. the main questions it aims to answer are: * to determine the success rate of capillary sampling at home by the patient * to assess reliability and satisfaction of (automated) capillary cea measurements participants will be asked to perform automated capillary sampling and lancet capillary sampling at home twice after regular check-up visits in the hospital, with an interval of 3-6 months in between. during this hospital visit, a cea measurement in blood sampled by venipuncture will be performed to act as a reference for the cea measurements in (automated) capillary blood to be sampled at home. reliability of cea measurements will be assessed for automated capillary and lancet capillary sampling compared to venipuncture. satisfaction in terms of patient reported outcomes (pain, burden, ease of use, and preference) will be evaluated.

the follow-up of patients after colorectal cancer surgery mainly consists of blood cea assessments. these blood assessments could be done at home and could be beneficial in terms of patients' well-being and societal cost-effectiveness. capillary blood sampling can be an alternative to venipuncture in home based or decentralized surveillance as it can be performed by the patient themselves. before home based capillary sampling can be implemented, feasibility, reliability, and satisfaction for serum cea measurements has to be determined.

Eligibility criteria:
inclusion criteria: arm a: subjects with known elevated serum cea * age ≥ 21 years * histologically confirmed (metastatic) colorectal adenocarcinoma * serum cea ≥ 10 μg/l within the last 2 months determined using venipuncture blood sampling arm b: subjects currently undergoing colorectal cancer related follow-up * age ≥ 21 years * histologically confirmed (metastatic) colorectal adenocarcinoma * currently undergoing in-hospital follow-up with at least two more scheduled serum cea assessments 3-6 months apart arm c: volunteers * age ≥ 21 years * no known history of colorectal adenocarcinoma * no known history of elevated serum cea ≥ 5 μg/l exclusion criteria: * illiteracy and/or insufficient proficiency of the dutch language * severe or complete loss of sensory and or motor function of one or both arms and or hands * known medical history of superficial or deep skin infection after venipuncture or intravenous line that required antibiotic treatment and or hospital admittance * known medical history of immunodeficiency or current use of medical immunosuppressants * known medical history of blood-borne diseases such as but not limited to the human immunodeficiency virus, hepatitis and viral hemorrhagic fever

Keywords: capillary sampling cea colorectal cancer home-based
omega 3 fatty acid efficiency for prevention of atrial fibrillation after coronary artery bypass grafting

Conditions: Ischemic Heart Disease; Atrial Fibrillation

Summary: the purpose of this study is to evaluate efficacy of polyunsaturated fatty acid for the prevention of atrial fibrillation and anti-inflammatory effects in patients after cabg surgery


Eligibility criteria:
inclusion criteria: * elective cabg surgery. * signed, documented informed consent prior to admission to the study. exclusion criteria: * unstable angina, requiring intervention or cabg \<24 hrs after screening. * decompensated congestive heart failure. * chronic, persistent, paroxysmal atrial fibrillation. * uncorrected significant valvular heart disease * known hypersensitivity to the study drug * left ventricular dysfunction (ejection fraction \<35%) * use of anti-arrhythmic drugs other than beta blockers * non-cardiac illness with a life expectancy of less than 1 year * bleeding diathesis or history of coagulopathy * significant renal and liver insufficiency * significant thyroid, pulmonary disease * uncontrolled diabetes mellitus * patients on anti-arrhythmic drugs * patients with pacemaker * patients unable to provide/sign informed consent. * patients currently taking marine based omega-three fish oil supplements. * disturbances in lipid metabolism, serum triglyceride value \>3 mmol/l

Keywords: omega-3 fatty acid ischemic heart disease atrial fibrillation subcutaneous cardiac monitoring