Kornimate/medical-research-clean huggingface dataset:
effectiveness of atraumatic restorative treatment using glass ionomer cement of different costs

Conditions: Dental Caries

Summary: atraumatic restorative treatment (art) is an alternative restorative technique for dental caries, applying the partial caries tissue removal philosophy using hand instruments, relative cotton rolls isolation, immediate restoration with glass ionomer cements (gic) and avoiding local anesthesia. the chosen material for this study will be the high viscosity glass ionomer cement (hvgic) due to its unique physical-chemical properties as well as its applicability in challenging clinical situations where other materials would not be adequate. although there are substantial evidences regarding gic properties, information about gic (with different costs) longevity is still weak. therefore, the objective of this study is to assess the effectiveness of art restorations performed with low-cost hvgic in cavitated dentine carious lesions in primary and permanent molars. this will be a multicenter randomized controlled double-blind (patient and operator) clinical trial performed with 680 primary and/or permanent molars in children between 4 and 9 years old presenting cavitated dentine carious lesions in occlusal and occlusal-proximal surfaces. the tooth will be considered as the unit sample, which will be randomly allocated to the groups through a generated random list numbers and distributed in dark sealed envelopes opened only by dental assistants. teeth in the test group will be submitted to restorative treatment with hvgic vitro molar and those in the control group with hvgic fuji ix. the restoration effectiveness will be assessed by means of both clinical and bitewing x-rays control after 6 and 12 months.


Eligibility criteria:
inclusion criteria: * children with at least one primary and/or permanent molar with dentine carious lesion in the occlusal and/or occlusal-proximal surface. exclusion criteria: * special need patients, subjects under orthodontic treatment and/or systemically compromised. * teeth with restorations, sealants, developmental defects, deep carious lesions with pulpal exposure risk, fistula and/or abscess, and those with history of spontaneous pain.

Keywords: tooth, deciduous dentition, permanent dental atraumatic restorative treatment glass ionomer cements dental caries
efficacy of platelet-rich plasma in treatment of melasma

Conditions: Melasma

Summary: the application of platelet rich plasma (prp) on three occasions with an interval of 15 days between each one, is related to a decrease in the intensity of the spots and improvement in the quality of the skin of patients with melasma.

832/5000 objective: to evaluate the effect of prp for melasma treatment. material and methods: prospective cohort with therapeutic intervention. patients, female, with melasma were included. changes in the melanin concentration of the face (masi), degree of satisfaction (melasqol) and histological changes were clinically evaluated. the sp-melasqol questionnaire, fitzpatrick and masi scales were applied, and photographs were taken with ambient light and with wood's light with the janus-ii general model. the patients were evaluated and classified, before and after the treatment by means of dermatoscopy, which was performed using a dermatoscope with polarized light (dermlite dl3n®), which allows an increase from 6 to 400x. the dermatoscopy reported the findings of: quantity, density and depth of melasma.

Eligibility criteria:
inclusion criteria: * previous diagnosis of melasma * history of pregnancy with a time greater than 6 months * informed consent exclusion criteria: * in lactation period * history of skin cancer * history of liver, thyroid diseases * with active acne lesions and traumatic lesions on the face * prp pre-treatmentpre-treatment for melasma with less than 6 months * hb values \<10 g / dl or platelet count \<105x109 / l

Keywords: platelet-rich plasma
rh-endostatin (endostar®) continuous intravenous infusion

Conditions: Lung Cancer

Summary: endostar is a anti-angiogenesis product and has been launched in china . the efficacy and safety have been defined. however, the compliance is unsatisfactory since routine i.v of endostar is needed for 3 to 4 hours daily during one cycle of 14 days. the continuous intravenous infusion by using venous pump can improve the compliance.


Eligibility criteria:
inclusion criteria: primary non-small cell lung cancer confirmed by cytology and histology, excluding sputum examination; phase iiib/iv based on tnm criteria (8th); at least one measurable tumor based on recist 1.1; without the known active mutation of egfr/alk/ros1/ret; male or female, age≥18 or ≤70 years old; ecog ps: 0 or 1; estimated time of survival: ≥ 3 months; suitable hematologic function: anc≥2×109/l, plc≥100×109/l and hb≥9 g/dl; suitable liver function: total bilirubin≤ normal uln, ast and alt≤2.5×normal uln, alp≤ 5×normal uln; suitable renal function: cr≤normal uln,or ccr≥60 ml/min; ekg normal; without healing wound; no history of anti-cancer therapy, or adjuvant/neo-adjuvant chemotherapy for non-metastatic tumor finished for more than 6 months before enrollment; for the female subject with productive ability, urine pregnancy test must be done and is negative within 7 days before enrollment; no history of serious allergic to biologic agents, especially e.coli products; the authorized icf must be signed. exclusion criteria: woman in pregnancy and breast-feeding, or having productive ability without contraception; having the serious acute infection uncontrolled or purulent/chronic infection with unhealed wound; having the serious heart disease, including congestive heart failure, uncontrolled high-risk arrhythmia, unstable angina, myocardial infarction, valvular disease, and refractory hypertension; having uncontrolled nervous or mental disease with low compliance and reluctance to description of response; uncontrolled primary brain tumor or other metastatic brain cancer with obvious intracranial hypertension or mental symptoms; having the tendency of bleeding, such as fib≤2g/l; being receiving adjuvant chemotherapy; on other conditions investigator considers, the subject is not fitful to participate the trial.
lithium disilicate glass-ceramic versus hybrid ceramic superstructure materials on implant stability

Conditions: Prosthesis Survival

Summary: the aim of this study is to assess the effect of the newly introduced (hybrid dental ceramic) superstructure materials, vita enamic versus ips emax on implant stability, patient satisfaction and crestal bone loss.

this study will be conducted on patients requiring single implant replacement in the maxillary premolar area, admitted to the outpatient clinic of fixed prosthodontics department, faculty of oral and dental medicine, cairo university. after a period of healing of 6 months, an implant abutment of accurate diameter and angulation will be placed to fit precisely into the internal hex of the fixture after removal of the cover screw. the platform matched abutment will be then secured into its final position using the abutment screw. alginate impression will be taken and poured into dental stone. using the impression transfers, impressions with polyvinylsiloxane are taken. after taking the impressions, the impression transfers are removed and fixed to the implant replica. surgeons' assistants will be asked to open the sealed envelope containing the information regarding the crown placement. the impressions will be sent to dental laboratory with the result of the sealed envelope, for preparation of the future crowns, either vita enamic crowns or ips e max crowns.

Eligibility criteria:
inclusion criteria: patients \> 18 yrs. patients with missing teeth in the maxillary premolar region. absence of any pathological condition in the recipient site. stabilization phase will be performed including: * scaling * debridement. * elimination of all carious cavities and root canal treatment if needed. * elimination of over-hanging restoration. systemic condition of the subjects was evaluated according to dental modification of the cornell medical index (kerr and millard 1966). patients who are cooperative, motivated, and hygiene conscious. patients should have adequate ridge width (\>5mm). exclusion criteria: patients unable to undergo minor surgical procedure. patients with history of drug abuse or metabolic drugs. patients with history of psychiatric disorder. patients with insufficient bone. patients with insufficient vertical inter-arch space, upon centric occlusion, to accommodate the available restorative components. patients with any systemic condition that may contraindicate implant therapy. patients that may have any habits that may jeopardize the osseo-integration process, such as heavy smoking and alcoholism. patients with para-functional habits that produce overload on the implant such as bruxism and clenching.

Keywords: implant supported restorations ips emax (lithium disilicate glass-ceramic) vita enamic (hybrid dental ceramic) implant survival peri-implant tissue response
standard non operative treatment versus accelerated rehabilitation of achilles tendon ruptures

Conditions: Rupture of Achilles Tendon

Summary: the purpose of this study is to directly compare traditional plaster treatment with early weightbearing in a walking boot for the non operative treatment of acute achilles tendon rupture.

this injury has traditionally been treated in a plaster cast applied to the leg for a period of 10 weeks which allows the tendon to heal, or by an operation to repair the tendon. research undertaken in the investigators department has shown that patients treated with surgery or with a plaster had similar chance of re-rupture of the tendon after treatment and gain a similar recovery. the investigators therefore now manage these injuries in a plaster. more recently, further research has shown that a new type of non-surgical rehabilitation programme, which is quicker than the traditional non-surgical programme, gave a tendon re-rupture rate that was similar to that after surgical treatment. this new rehabilitation programme uses a walking boot fitted with a heel-raise (instead of the traditional plaster). the potential benefit of this quicker rehabilitation programme is that it allows the patient to put weight through the leg immediately, whereas patients treated with the traditional plaster cast non-surgical treatment cannot weight bear (this means that they are kept non-weightbearing and therefore have to use crutches) for the first 8 weeks. the time spent in the walking boot in this new, quicker rehabilitation programme is 8 weeks while that spent in plaster is 10 weeks. this new non-surgical, quicker rehabilitation programme is referred to as the accelerated non-surgical programme hereafter. there are no known increased risks with the accelerated rehabilitation programme.

Eligibility criteria:
inclusion criteria: * patients aged 16-60 years old with an acute rupture of the achilles tendon exclusion criteria: * patients who do not have an acute rupture (ie. delayed presentation \>2 weeks) * patients who present with a re-rupture of a previously treated achilles tendon * patients from outside the lothian (local treatment) area who are unwilling to attend follow-up at the study institution. * latex allergy.
the effectiveness of stingless bee honey (kelulut honey) versus gel in diabetic wound bed preparation

Conditions: Diabetes Mellitus; Wound Heal; Diabetes; Honey

Summary: there has been no study yet on the effect of stingless bee honey (kelulut honey) produced by melipolini sp. in diabetic wound healing in malaysia. kelulut honey, apart from possessing similar pro-healing properties with other honey, is also found to have a better antioxidant capacity, anti-inflammatory, and free radical scavenging activity than tualang honey. these effects are due to the much higher content of phenolic and flavonoid substances in kelulut honey, the key bioactive factors promoting wound healing and preventing oxidative stress-related injury. australian researchers have also recently discovered a novel source of the rare disaccharide trehalose in stingless bee's honey, which is highly anti-diabetic and antioxidating. this study aims to investigate the efficacy of honey against gel dressing for wound bed preparation among diabetic patients.


Eligibility criteria:
inclusion criteria: * male and female * aged between 18-70 years old * patient with full thickness cavity wound * controlled diabetes mellitus (defined as: fasting blood glucose (fbg) \< 10 mmol/l upon selection) exclusion criteria: * severely contaminated wound/infected * patient with history of allergy to honey or stingless bee product * patients who are immunocompromised or on chronic steroid use ( defined as use of steroid for more than 2 weeks) * pregnancy * end stage renal failure (esrf) patient
leqvio rpms (regulatory post-marketing surveillance in korea)

Conditions: Primary Hypercholesterolemia or Mixed Dyslipidemia

Summary: this non-interventional study is a mandatory regular post marketing surveillance(rpms) granted by the korean health authorities, and is conducted to assess the effectiveness and safety of leqvio® pre-filled syringe(inclisiran sodium) in routine clinical practice for the approved indications (primary hypercholesterolemia or mixed dyslipidemia).


Eligibility criteria:
inclusion criteria: if a subject meets all of the following criteria, he/she can participate in this study: 1. adult patients(18 years or older) who have hypercholesterolemia or mixed dyslipidemia and are prescribed leqvio® pre-filled syringe(inclisiran sodium) according to domestically approved product information in real clinical practice 2. patients who are unable to reach ldl-c target with maximum tolerated dose of statin, or patients with statin intolerance 3. patients who provided consent to participate in the study(informed consent form) exclusion criteria: a subjects who meets any of the following criteria cannot participate in this study: 1. contraindications in accordance with domestic prescribing information 2. patients participating in clinical trials of other investigational drugs 3. patients who do not provide consent to participate in the study

Keywords: primary hypercholesterolemia, mixed dyslipidemia inclisiran leqvio
the dna methylation of arhgef11 in macrosomia

Conditions: Gestational Diabetes; Diabetes; Macrosomia, Fetal

Summary: background macrosomia at birth is associated with subsequent susceptibility to obesity, abnormal glucose metabolism, hypertension and dyslipidaemia. epigenetic reprogramming has been reported to be involved in the development of human diseases caused by suboptimal environmental or nutritional factors. objective the study was aiming to explore epigenetic mechanism influences on macrosomic infants exposed to intrauterine hyperglycemia. design the investigators performed a genome-wide analysis of dna methylation in cord blood from macrosomic infants born to women with gestational diabetes or infants with normal birth weight born to normal glucose-tolerant women in order to identify genes related to foetal growth or early adipose tissue development. the candidate genes were then validated using sequenom massarray after bisulfite conversion.


Eligibility criteria:
inclusion criteria: - exclusion criteria: * pregnancies complicating with hypertensive disorders, pre-gestational diabetes, thyroid diseases, renal dysfunction were excluded.
traumatized refugees -stress management versus cognitive re-structuring

Conditions: Posttraumatic Stress Disorder

Summary: the competence centre for transcultural psychiatry is a clinic specialised in the treatment of traumatised refugees. there is a lack of studies on treatment effect in traumatised refugees. there are several studies indicating an effect of cognitive behavioural therapy (cbt) in posttraumatic stress disorder (ptsd). a few studies point to that cbt could be effective in traumatised refugees. there are no studies examining if some methods used in cbt are more useful than others in traumatised refugees. the aim of this study is to examine the effect of cbt with focus on stress management versus cognitive restructuring. patients included in this study will be randomised to either stress management or cognitive restructuring. all referred patients will receive medical treatment as usual (described in the clinic's manual for medical doctors, 2011). all patients that fulfill the inclusion criteria will be included in the study. hopefully this study will contribute to improve the psychotherapeutic treatment offered to traumatised refugees.


Eligibility criteria:
inclusion criteria: * refugee or patient that has been reunified with family member being a refugee. * symptoms of ptsd in accordance with international classification of diseases-10 (icd-10) research criteria. * trauma in the past such as imprisonment, torture (according to un definition), war experiences. * referred by a medical doctor. * motivated for treatment. * informed consent. exclusion criteria: * severe psychotic illness such as schizophrenia or bipolar disorder * drug abuse * patients admitted to in ward treatment * no informed consent

Keywords: ptsd depression refugees trauma
anesthesia awareness in pediatric gastrointestinal endoscopy nurses

Conditions: Endoscopy; Knowledge; Attitudes, Staff; Nurse's Role; Awareness, Anesthesia

Summary: background and aim: pediatric gastrointestinal (gi) endoscopy is an increasingly common procedure performed to investigate and diagnose problems in the gi tract in children. procedures in pediatric endoscopy units are routinely performed under sedation and general anesthesia, unlike adult endoscopy. nurses working in pediatric gastroenoscopy units where sedoanalgesia is applied have important duties and responsibilities in terms of quality standards in preoperative, intraoperative and postoperative periods. considering the increasing need for high-quality pediatric endoscopy applications, the attitudes and behaviors of nurses about sedation in pediatric patients are important as a member of the team. there is almost no literature on the experience and awareness of pediatric endoscopy nurses in clinical practice, and this encourages our team to conduct a survey across our country and to develop knowledge and clinical practices. with this questionnaire survey, it was aimed to evaluate the experience and attitudes of the endoscopy nurses working in the pediatric endoscopy unit in our country on sedation/general anesthesia management for pediatric patients

design: this research is a questionnaire survey. there will be no scaling in survey questions. the volunteers who will participate in the survey are nurses working in the pediatric endoscopy unit throughout turkey, and the sample size was not calculated because it was desired to study in the whole universe and sampling was not used. approximately 80 endoscopy nurses work in the pediatric endoscopy unit in turkey. the universe consists of about 80 volunteers. power analysis of the research will be done after the study is completed. methods: for this study, pediatric endoscopy nurses working in different clinics across our country will be invited. questionnaires will be delivered to nurses through hospital visits or electronic media. the prepared questionnaire consists of a total of 33 questions evaluating nursing services on demographic data and sedation practices in pediatric endoscopy nurses' units. of the 33 questions, 7 of them question the information about the socio-demographic data and professional experience of the pediatric endoscopy nurses, 16 of which will be answered as "yes" or "no" about the nursing services and approaches related to anesthesia management, the remaining 10 will consist of questions to be answered as "i agree" "i am undecided" "i do not agree".

Eligibility criteria:
inclusion criteria: * all pediatric endoscopy nurses working in the pediatric endoscopy unit in our country exclusion criteria: * pediatric endoscopy nurses who will not want to participate in this questionnaire survey

Keywords: pediatric endoscopy nurse awareness, anesthesia questionnaire survey
historical control study of refractory ifi or patients intolerant to standard antifungal therapy in patients with invasive fungal infections (study p02387)

Conditions: Infection, Invasive Fungal

Summary: this retrospective study is designed to provide a consistent method of screening and collecting data on patients who will serve as controls for a comparison of the efficacy of the available antifungal therapies used as salvage treatments for patients with refractory ifi or for patients with refractory ifi or for patients with ifi who are intolerant to standard antifungal therapies.

the current clinical trial is designed to provide historicals controls comparable to the p00041 study population, that is, a) patients with invasive fungal infections which are refractory or resistant to standard antifungal therapies or b) patients who have developed intolerance to standard antifungal therapy. this clinical trial also serves to allow collection of historical data regarding the efficacy of available antifungal therapies against a variety of invasive fungal infections which although serious and life-threatening are sufficiently rare so that they cannot be studied in a controlled, randomized clinical trial. this trial will be conducted primarily at the investigative sites that enrolled subjects into p00041 and/or investigators who are members of the mycosis study group.

Eligibility criteria:
inclusion criteria: * males and females of any race greater than or equal to 13 years of age * treatment for an ifi between april 30, 1996 and april 30, 2001 at one of the centers participating in p00041 or at other non-p00041 centers * a diagnosis of proven or probable ifi based on msg/eortc criteria * refractory ifi or intolerence to standard therapy the date of diagnosis of an ifi will be the earliest date on which one or more of the following diagnostic procedures used to establish the diagnosis was performed: * fungal culture, histopathology, bronchoscopy, and autopsy report * x-rays, ct scan, mri, ultrasound, and bone scan * serology exclusion criteria: 1. female subject who was pregnant or nursing at the time ifi was diagnosed 2. hepatic function tests: alt or ast greater than 10 times the upper limit of normal at the time ifi was diagnosed 3. enrollment in p00041 for treatment of the ifi 4. patient with sarcoidosis, aspergilloma, or allergic bronchopulmonary aspergillosis 5. patients with chronic invasive aspergillosis (chronic necrotizing pulmonary aspergillosis) 6. patients with diagnosis of cmv pneumonia 7. patients with a diagnosis of pulmonary tuberculosis 8. death within 72 hours of the start of antifungal therapy 9. patients on artificial ventilation, who were not extubated within 24 hours of commencing standard antifungal therapy

Keywords: aspergillosis candidiasismucormycosis fusariosiscryptococcosis endemic fungal infections phaeohyphomycosis
surestep: transcranial direct current stimulation in super refractory status epilepticus

Conditions: Status Epilepticus

Summary: the purpose of this study is to determine whether transcranial direct current stimulation affects super refractory status epilepticus.


Eligibility criteria:
inclusion criteria: * diagnosis of super refractory status epilepticus * admitted to the intensive care unit * identifiable epileptogenic focus on eeg exclusion criteria: * contraindications to scalp eeg * lice * scabies * other hair/skin infection * scalp psoriasis * hypersensitivity * other severe dermatological condition * previous adverse reaction to collodion * vagal nerve stimulator * implantable cardioverter defibrillator * cardiac pacemaker