Kornimate/medical-research-clean huggingface dataset:
life style modification medical and surgical management in patients with obesity

Conditions: Obesity; Weight Change, Body; Obesity; Endocrine; Obesity, Metabolically Benign

Summary: in this is an observational study, obese patients that administed and followed in endocrinology clinic of marmara university medical school hospital will follow for clinical and laboratory parameters prospectively for 5 years

following available clinical and laboratory parameters will be collected for 5 years treatment modalities ( life stye modification, medication, bariatric surgery) eating habits quality of life body mass index , blood pressure body fat distribution (impedance measurement) laboratory parameters (serum glucose, ogtt, insülin, lipids,creatinin ,alt ast,cbc, ferritin calcium, phosphate, parathormone,25 oh vitamin d, vitamin b12 ,uric acid, albumin, fsh lh testosteron, estrogen ) muscle strength (dynomometer measurement) skin glikolization autoflouresent measurement bone mineral density mesurements (femur, spine ,forarm)

Eligibility criteria:
inclusion criteria: body mass index over 30 kg/m2 age between 18-65 years exclusion criteria: active malignancy pregnancy during involvement period chronic inflamatuar diseases

Keywords: obesity weight loss
systematic screening for obstructive sleep apnea during preoperative consultation using ai-preoperative agents

Conditions: Obstructive Sleep Apnea; Preoperative Evaluation

Summary: the goal of this observational study is to evaluate the feasibility of a systematic screening protocol for obstructive sleep apnea (osa) during preoperative anesthesia consultations in adults aged 50 and older undergoing elective surgery. the main questions it aims to answer are: * does the systematic screening protocol increase the proportion of patients identified as being at high risk for osa compared to standard care? * what is the impact of systematic screening on postoperative outcomes, including complications, length of stay, and mortality? researchers will compare standard care practices (before implementation) to the systematic screening protocol (after implementation) to determine the effect on osa detection rates and clinical outcomes. participants will: * complete the stop-bang questionnaire during their anesthesia consultation. * (optional) have a facial photograph taken to analyze morphometric characteristics that may correlate with osa risk. * be referred for further diagnostic testing if identified as high-risk for osa.


Eligibility criteria:
inclusion criteria: * all patients with a national health identifier affiliated with the social security system, aged over 18, including french individuals over 50 years old, in scheduled anesthesia consultation with stop bang \> 5 or \> 4 with bmi \> 35 exclusion criteria: * refusal to participate in the study, age under 50, not affiliated with the social security system, minor or under legal protection

Keywords: preoperative stop-bang score obstructive sleep apnea ai osa
comfort and wearability of custom-fitted, mouth-formed and pre-fabricated mouthguards for patients undergoing fixed appliance therapy

Conditions: Mouth Protectors

Summary: there is no current evidence on the comfort or wearability of orthodontic mouthguards. these mouthguards adapt to the mouth without the need for dental impressions and laboratory facilities and are suggested to be more comfortable for orthodontic patients by allowing the teeth to move during treatment without the need for them to be replaced regularly during treatment. this study aims to assess and compare the comfort and wearability of orthodontic mouthguards with custom-fitted mouthguards. the results of this study will allow orthodontists to provide evidence-based information to individuals undergoing fixed appliance therapy.


Eligibility criteria:
inclusion criteria: * undergoing active orthodontic treatment with pre-adjusted edgewise fixed appliances only for a minimum period of 9 months * playing sports where the use of a mouthguard is recommended * playing at least 120 minutes of sport (match or training) during a 6-8 week period * class i, ii or mild iii (edge-to-edge) incisor malocclusion * able to complete a vas questionnaire * no diagnosed sensory processing disorder exclusion criteria: * undergoing active orthodontic treatment that is not pre-adjusted edgewise fixed appliances, or requires a fixed expander, or treatment is likely to be completed within 9 months * playing sports where the use of a mouthguard is not recommended playing less than 120 minutes of sport (match or training) during a 6-8 week period * moderate to severe class iii (reverse overjet) incisor malocclusion * unable to complete a vas questionnaire * have a diagnosed sensory processing disorder

Keywords: mouth protectors
study of vitamin a and carbomer in comforting the ocular surface irritations of glaucoma patients

Conditions: Primary Open-angle Glaucoma

Summary: most of the patients under long application of anti-glaucoma eyedrops endure severe ocular surface irritation, which interrupt their quality of life a lot. lots of studies aimed to search for new drugs for therapy. the investigators hypothesized that the artificial tears containing vitamin a or carbomer may be a great substitute. both of the two drugs were in common use and had already been tested in animals.


Eligibility criteria:
inclusion criteria: - diagnosed primary open-angle glaucoma or normal tension glaucoma patients with prostaglandin analogs treatment for more than one year. exclusion criteria: 1. any systemic diseases which may cause ocular damage; 2. previous ocular trauma or surgery; 3. contact lens wear history in previous 6 months; 4. application of any artificial tears 3 months ago; 5. allergic to any of the drugs we used during examination.
safety and pharmacokinetic study of subcutaneous alxn1720 in participants with proteinuria

Conditions: Proteinuria

Summary: the primary objective of this study is to assess the impact of proteinuria on the pharmacokinetic (pk) of a single dose of alxn1720 in participants with proteinuria.


Eligibility criteria:
inclusion criteria: * documented diagnosis of lupus nephritis, iga nephropathy, primary membranous nephropathy, focal segmental glomerulosclerosis, diabetic nephropathy, hypertensive nephrosclerosis, minimal change disease, thin basement membrane nephropathy or membranoproliferative glomerulonephritis (all forms). other cause of kidney disease may be included per investigator agreement with the sponsor * proteinuria \>=1 based on absolute amount in grams per day (g/d) as measured in one complete and valid 24-hour urine collection during screening * body weight ≥ 40 kg at screening exclusion criteria: * kidney transplant * estimated glomerular filtration rate (egfr) \< 30 ml/min/1.73 m2 during screening * known medical or psychological condition(s) or risk factor that, in the opinion of the investigator, might interfere with the participant's full participation in the study, pose any additional risk for the participant, or confound the assessment of the participant or outcome of the study. * treatment with complement inhibitors at any time. * treatment with rituximab within 6 months before initiation of study drug on day 1; or, planned treatment with rituximab within 3 months after initiation of study drug on day 1. * participation in another investigational drug or investigational device study within 30 days before initiation of study drug on day 1 in this study or within 5 half-lives of that investigational product, whichever is greater.

Keywords: proteinuria glomerular disease chronic kidney disease lupus nephritis immunoglobulin a nephropathy primary membranous nephropathy focal segmental glomerulosclerosis diabetic nephropathy hypertensive nephrosclerosis minimal change disease thin basement membrane nephropathy membranoproliferative glomerulonephritis (all forms)
the influence of cognitive status on walking abilities after femoral neck fracture

Conditions: Hip Fracture; Femoral Neck Fracture

Summary: introduction: femoral neck fracture is a devastating injury with serious medical and social consequences. one third of these patients have some degree of impaired cognitive status. despite of this, a high proportion of hip fracture trials exclude patients with cognitive impairment. the investigators aimed to evaluate whether moderate to severe cognitive impairment could predict walking ability, quality of life, functional outcome, reoperations and mortality in elderly patients treated with hemiarthroplasty. methods: this cohort study included a consecutive series of 188 patients treated with hemiarthroplasty for an displaced femoral neck fracture. patient were assessed for estimated preoperative and 1 year postoperatively with regard to walking abilities, cognitive status, quality of life with eq-5d and hip function with harris hip score.


Eligibility criteria:
inclusion criteria: * 65 year or above * displaced femoral neck fracture * treated with a hemiarthroplasty exclusion criteria: * pathological fractures * bilateral femoral neck fractures * bed-ridden patients.
evaluation of clinical significance and feasibility of ct guided biopsy of double site lesions：a preliminary lung centered study

Conditions: Carcinoma of the Lungs

Summary: this study aims to explore the clinical significance and feasibility of double site biopsy by analyzing the pathological characteristics and the incidence of main complications of ct guided puncture biopsy of lung and other parts coexisting lesions.

ct guided biopsy is minimally invasive, accurate and low cost. it is often used as an important diagnostic method when the clinical suspect of malignant disease or the treatment effect of the disease is not good. in patients with suspected malignant lung disease, metastasis of other parts of lung, pulmonary door, mediastinum, bone, and distant soft tissue may be combined at the same time. it is the key link of clinical work to evaluate the nature of these coexisting lesions accurately and choose appropriate treatment methods. at present, there is little clinical study on lung centered double site biopsy. this study aims to explore the clinical significance and feasibility of double site biopsy by analyzing the pathological characteristics and the incidence of main complications of ct guided puncture biopsy of lung and other parts coexisting lesions.

Eligibility criteria:
inclusion criteria: * patients with suspected malignancy * underwent dual site ct guided biopsy in the third hospital of peking university exclusion criteria: -
norwegian cognitive impairment after stroke (norcoast) study

Conditions: Dementia; Mild Cognitive Impairment; Stroke

Summary: a prospective observational multicenter study aiming to describe incidence, and identify predictors for development of poststroke dementia (psd) and mild cognitive impairment (mci) after stroke

about 15000 norwegians suffer a stroke every year and 2/3 will be more or less disabled. in addition to motor impairments and comorbidities, disability after stroke is often related to post stroke dementia (psd) or mild neurocognitive disorder (ncd). however, these problems are hardly addressed in stroke or dementia research and frequently ignored in clinical practise. in the nor-coast study an interdisciplinary research group will collaborate to establish a research platform across all norwegian health authorities. the overall aim of the study is to improve competence on psd and ncd in order to improve individual health outcomes following a stroke. the specific objectives are to determine the incidence of psd and ncd and the consequences on function and use of health care services and to enhance the early detection of psd and ncd by identifying a set of risk factors, ranging from genetics to physical activity. the incidence and impact of psd and ncd on function and use of health care services, medication and life-style changes are important when planning future health care services. tools identifying patients at risk might improve diagnostic work up and together with knowledge on pathogenic aspects it will contribute to future treatment and prevention of psd and ncd.

Eligibility criteria:
inclusion criteria: * stroke diagnosis according to the who criteria exclusion criteria: * not scandinavian speaking

Keywords: follow up studies risk factors
effect of open kinetic chain shoulder exercises on scapulothoracic muscle activity on stable and unstable ground

Conditions: Muscle Weakness; Exercise

Summary: exercises used in shoulder rehabilitation compose of open kinetic chain and closed kinetic chain exercises.the force formed on the trunk and legs is transferred to the shoulder in open and closed kinetic chain exercises before shoulder muscles activation. it was shown that trunk and leg muscle activity changes when they are performed in different ground. but it is unknown how this alteration effect shoulder muscle activity. this will be provide a significance approach due to incremented of shoulder muscle activity is important for shoulder rehabilitation setting. to achieve this aim that is rising of muscle activity, various approach is applied including alteration of ground which individual performed exercise on it. and, it was shown that closed cinetic chain exercise which performed on different ground change shoulder muscle activity. however, it is unknown whether alteration of ground effect shoulder muscle activity or not in open cinetic chain exercise. that's why the aim of this study is to investigate alteration of scapulothoracic shoulder muscle activity in open cinetic chain shoulder exercise which enforced different ground.


Eligibility criteria:
inclusion criteria: * being healthy * right hand dominant * ages between 20-45 years * to be volunteer participate in the study exclusion criteria: * having any shoulder pain in current or in the past * any previous surgery * pain in any part of the body * doing regularly a professional sports * neurological disease * systemic disease
bs01 in patients with retinitis pigmentosa

Conditions: Retinitis Pigmentosa

Summary: a phase 1/2, safety and efficacy trial of bs01, a recombinant adeno-associated virus vector expressing chronosfp (aav2-cag-chronosfp) in patients with retinitis pigmentosa


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of retinitis pigmentosa * bare light perception in at least one eye exclusion criteria: * prior receipt of any aav gene therapy product * large amplitude nystagmus
cognoa autism spectrum disorder (asd) digital therapeutic engagement and usability study

Conditions: Autism Spectrum Disorder

Summary: cognoa will measure usability, engagement with the device, and changes in parent-reported socialization during a 4-week period of intervention at home with the cognoa asd therapeutic device.

parents who consent will be given access to the study device through its caregiver and child-facing smartphone app that provides therapeutic content. in order to access the study device app, parents will be provided access to two other apps. the first is testflight. testflight is an online service for over-the-air installation and testing of mobile applications, currently owned by apple inc.that allows users to test ios apps before they are released to the app store. parents will also be provided access to the cognoa for child development app in order to create an account as a means to gain access to the study device app. the parents will only be able to engage with the study device app once they have created an account in the cognoa for child for development app

Eligibility criteria:
inclusion criteria: * functional english language capability in the home environment. * parent, guardian, or legal authorized representative (lar) must be able to read, understand and sign the informed consent form (icf) * female or male, \> 3 to \< 9 years of age and parent/caregiver * diagnosis of autism spectrum disorder, within the last 12 months * parent, guardian, or legal authorized representative (lar) must have smartphone capabilities for downloading testflight software; test versions of the cognoa for child development app; and test versions of the cognoa digital therapeutic app (ios 12.0 and up and apple iphone 8 and higher) exclusion criteria: * participants with any other medical, behavioral, or developmental condition that in the opinion of the investigator may confound study data/assessments. * participants with planned extensive travel (more than 1 week) during the course of the 4 week intervention time period. * participants with deafness or blindness. * participants with known physical impairments affecting their ability to use their hands. * participants with active diagnosis of epilepsy and uncontrolled seizures. * participants whose age on the date of enrollment is outside the target age range
early detection of renal abnormalities in metabolically healthy and unhealthy weight excess"

Conditions: Obesity

Summary: overweight and obesity are increasingly prevalent worldwide. weight excess increases the risk of in developing the metabolic syndrome, which is composed by a set of cardiometabolic risk factors such as abdominal adiposity, dyslipidemia, high blood pressure and elevated fasting glucose levels. obesity and the metabolic syndrome are known to be risk factors for the development of chronic kidney disease. it is not clear however, whether they can be considered independent risk factors for impaired renal function and renal damage. whereas obesity may represent an independent risk factor for renal damage, it is not clear yet if the contemporaneous presence of obesity and metabolic alterations is associated with an additional increase in the risk. it may be important to understand the relationship between obesity, metabolic syndrome and renal health, as treatment strategies may be different for the two metabolic phenotypes of obesity, i.e., metabolically healthy obese (mho) and metabolically unhealthy obese (muo) patients. the primary objective of this multicentre observational prospective study is to assess the relationship between metabolic phenotype and reduced renal function (glomerular filtration rate \<90 ml/min/1.73m2 or microalbuminuria 30-300 mg/24h) in a population of 1000 patients with overweight or obesity. the secondary aim is to study the association between diet quality, consumption of ultra-processed foods and indicators of reduced renal function and renal damage.


Eligibility criteria:
inclusion criteria: * age between 18 and 60 years * bmi at least 25 kg/m2 exclusion criteria: * pregnancy or breastfeeding * diabetes mellitus * renal disease * systemic autoimmune diseases with possible renal involvement * agonistic physical activity * heart failure * pharmacologcal treatment with raas-inhibitors, sartans, thiazide diuretics, loop diuretics * urinary tract infection

Keywords: metabolic phenotype renal function
su5416 in patients with aids-related kaposi's sarcoma who have not responded to treatment

Conditions: Sarcoma, Kaposi; HIV Infections

Summary: the purpose of this study is to test the effectiveness of su5416 in patients with aids-related kaposi's sarcoma (ks).

patients are given su5416 via twice-weekly intravenous infusions in 4-week treatment cycles. any patient who has not experienced unacceptable toxicity and who is deemed to be responding to the study drug (no evidence of disease progression) is permitted to continue receiving su5416 in 4-week treatment cycles (up to a maximum of 1 year of therapy) until that patient experiences either unacceptable toxicity or tumor progression, as defined in the protocol.

Eligibility criteria:
inclusion criteria patients may be eligible for this study if they: * are at least 18 years old. * have ks. * have taken paclitaxel, daunoxome, or doxil for ks and they have either not gotten better or could not tolerate treatment therapy. * have 1 of the following symptoms for ks: 5 lesions (sores), generalized ks-related edema (swelling) without sores, or ks-related edema of the arms and legs. * agree to use an effective method of birth control during the study. exclusion criteria patients will not be eligible for this study if they: * are pregnant or breast-feeding. * are allergic to cremophor.

Keywords: skin neoplasms sarcoma, kaposi acquired immunodeficiency syndrome antineoplastic agents enzyme inhibitors su 5416 protein-tyrosine kinase
immunological interaction between the host and candida albicans biofilm

Conditions: Candidiasis

Summary: candida albicans is one of the most common nosocomial infection and the onset relies on the host immune status. the purpose of this study is to determine the immunological profile of patients infected with candida albicans, that could ideally lead to a strategy to identify patients who could benefit from prophylaxis.


Eligibility criteria:
inclusion criteria: * patients infected with candida albicans * patients not infected with candida albicans exclusion criteria: * underage patients * non consenting patients * unconscious patients

Keywords: candida albicans candidiasis biofilm flow cytometry mannose binding lectin
testing a new imaging agent to identify cancer

Conditions: HER-2 Positive Malignant Carcinoma of Breast; HER-2 Protein Overexpression; HER2-positive Metastatic Breast Cancer

Summary: the purpose of this study is to see whether 89zr-ss-pertuzumab is safe in people with her2+ cancer.


Eligibility criteria:
inclusion criteria: * biopsy proven her2-positive or her2-low primary malignancy or metastatic disease note: her2 positivity is defined according to american society of clinical oncology guidelines or erbb2 amplification on next generation sequencing note: her2-low is defined as low her2 expression, with immunohistochemistry (ihc) 1+ or ihc 2+ and in situ hybridization \[ish\]-negative, including fish. * biopsy proven primary malignancy or metastatic disease * at least one malignant lesion on ct, mr, or fdg pet/ct within 60 days of protocol enrollment * age 18 years or greater * ecog performance of 0-2 exclusion criteria: * creatinine \> 2 times normal limit (obtained with 8 weeks of enrollment) * ast/alt \> 2 times normal limit (obtained with 8 weeks of enrollment) * life expectancy \< 3 months * pregnancy or lactation * patients who cannot undergo pet/ct due to weight limits (over 450 pounds)

Keywords: her-2 positive malignant carcinoma of breast her-2 protein overexpression her2-positive metastatic breast cancer 3+ her2 ihc 2+ her2 ihc 20-275 memorial sloan kettering cancer center her2-positive primary malignancy zr-ss-pertuzumab
evaluation the role of laparoscopic management of perforated appendicitis

Conditions: Perforated Appendicitis

Summary: a laparoscopic appendectomy (la) was first reported by semm in 1983. since then, its advantages, such as the aesthetic appearance of the wound, less postoperative pain, and faster recovery which facilitates early discharge, have been highlighted, and the number of procedures performed has been continuously increasing.

the la was performed mostly on uncomplicated appendicitis due to negative opinions about its safety when it was first introduced. however, the application of the procedure has been extended to complicated appendicitis (ca), and it is now considered as an alternative procedure to an open appendectomy (oa) as its safety record has improved . nevertheless, it is still controversial because there are still concerns about surgical difficulties in managing ca with laparoscopy, overall surgery time, possible post-op complications and conversion to an oa during the surgery. this study aimed to evaluate the safety and the efficacy of la for managing perforated appendicitis.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute perforated appendicitis * fit for laparoscopy and general anesthesia. * written informed consent. * short term outcome data and agree to provide contact information. exclusion criteria: * high risk for general anesthesia. * appendicular abscess and appendicular mass . * ongoing infections including chest infections . * children and pregnant females .