Kornimate/medical-research-clean huggingface dataset:
neurotransmitter measurements using (wincs) during deep brain stimulation neurosurgery

Conditions: Essential Tremor; Parkinson's Disease; Dystonia

Summary: in this study, the investigators will monitor extracellular neurotransmitter levels using a probe that is able to perform real time electrochemical detection during deep brain stimulation surgery. the overall question this study is designed to answer is: are there neurotransmitters released during deep brain stimulation?

in this study, the investigators will monitor extracellular neurotransmitter levels using a probe that is able to perform realtime electrochemical detection during dbs neurosurgery. the overall question this study is designed to answer is: are there neurotransmitters released during deep brain stimulation? we propose to enroll 45 patients (15 patients each at the three targets for dbs) with essential tremor, parkinson's disease, and dystonia who are undergoing dbs neurosurgery. this will be an acute study. patients with medically identifiable symptoms of the above diseases who have been approved by mayo dbs committee for implantation of dbs will be selected for this study. these patients will then be consented preoperatively to undergo extracellular electrophysiology which is typical in these cases to determine the target site for implantation of the dbs electrodes. following this electrophysiologic procedure, the patient will have electrochemical electrode implanted to (1) determine whether there is adenosine release at the site of stimulation during ventral intermediate nucleus (vim) thalamic dbs, (2) determine whether there is dopamine and adenosine release within the caudate nucleus or putamen during subthalamic nucleus dbs, and (3) determine whether there is dopamine and adenosine release at the site of stimulation during globus pallidus dbs.

Eligibility criteria:
inclusion criteria: * adult patients with medically intractable essential tremor, parkinson's disease, and dystonia who have been approved for dbs surgery by the interdisciplinary mayo dbs committee. exclusion criteria: * pregnant patients, * prisoners, * children (age less than 18), and * any patients identified as unsuitable for these protocol by the mayo dbs committee.
efficacy study of a new antimicrobial wound dressing to treat wounds caused by curettage and electrodesiccation

Conditions: Acute Wounds

Summary: the purpose of this pilot clinical study is to compare healing rates, pain levels, and incidence of wound complications including infection with the use of a moist procellera™ antimicrobial wound dressing when compared to a standard dressing, mepilex® border lite, following curettage and electrodesiccation of skin lesions.


Eligibility criteria:
inclusion criteria: if female, must either be not of childbearing potential or if they are of childbearing potential must have a negative urine pregnancy test. * wound size greater than 1x1 cm * wounds must be ≥5 cm away from all other wounds * wound size must not be diminished in size greater than 10% between enrollment in study and the prescreening * participant agrees to participate in follow-up evaluation * participant must be able to read and understand informed consent, and sign the informed consent exclusion criteria: * concurrent participation in another clinical trial that involves an investigational drug or device that would interfere with this study * participant is to receive another topical antimicrobial agent other than the study dressing * participant with sensitivity or adverse reactions to silver or zinc * pregnancy or nursing an infant or child * immunosuppression * active or systemic infection * peripheral vascular occlusive disease * collagen vascular disease * connective tissue disease * diabetes * venous stasis ulcers * participant undergoing active cancer chemotherapy * chronic steroid use * decision impairment

Keywords: curettage and electrodesiccation acute wounds partial thickness wounds
validation of icg to identify the urethra during rectal surgery

Conditions: Urethra Injury; Rectal Cancer; Surgery

Summary: this is an open-label feasibility study utilising direct instillation of icg into the urethra during surgery for low rectal cancers. the trial involves a single intervention taking place during the patient's operation. participants will be included in the study for around 2 months with time either side of the intervention to collect background data.


Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the study. * male, aged 18 years or above. * undergoing low rectal surgery where the operating field will be close to the urethra exclusion criteria: * participant has an allergy to iodine or icg * known liver failure

Keywords: fluorescence
role of negative pressure wound therapy in latissimus dorsi flap donor site seroma prevention

Conditions: NPWT; Latissimus Dorsi Flap; Breast Reconstruction

Summary: the use of npwt as a post-operative dressing significantly reduces the incidence of seroma formation after harvesting ld flap.

npwt was left in place on donor site with constant pressure between -125 and -80 mmhg to reduce seroma formation

Eligibility criteria:
inclusion criteria: * age between 20-60 years underwent breast reconstruction with ld flap exclusion criteria: * locally advanced cancer
outcomes of anterior colporrhaphy versus graft reinforced anterior prolapse repair

Conditions: Cystocele; Uterine Prolapse; Urinary Incontinence

Summary: the purpose of this study is determine whether grafted anterior vaginal prolapse repair is more effective and associated with less complications than prolapse repair with suture.

successful correction of anterior vaginal prolapse remains one of the most challenging aspects of pelvic reconstructive surgery. up to 70% have recurrent prolapse following anterior colporrhaphy. the low success rate has consequently led to widespread use of grafts in anterior vaginal prolapse repair. while both biologic grafts and polyglactin 910 mesh have yielded disappointing results, uncontrolled studies have demonstrated low recurrence rates with polypropylene mesh reinforcement. the perigee transobturator prolapse repair system (perigee tprs) (american medical systems, minnetonka, minnesota) is used to repair anterior vaginal prolapse via a transobturator approach. specially-designed helical needles are utilized to attach either a porcine dermal (intexentm) or soft polypropylene (inteprotm) graft to the pelvic sidewall at four points. we designed this randomized control trial to compare the anatomic success rates, effect on quality of life and sexual symptom scores, and rates of adverse events of the perigee tprs with polypropylene mesh to that of anterior colporrhaphy.

Eligibility criteria:
inclusion criteria: * stage ii or greater anterior vaginal prolapse requiring surgical correction * age 21 years and older exclusion criteria: * less than stage ii anterior vaginal prolapse * decline participation * pregnant or contemplating future pregnancy * prior anterior vaginal prolapse repair with biologic or synthetic graft * active or latent systemic infection * compromised immune system * previous pelvic irradiation or cancer * known hypersensitivity to polypropylene * uncontrolled diabetes mellitus * unable or unwilling to give valid informed consent * unable or unwilling to comply with the protocol * scheduled to undergo concomitant burch colposuspension or pubovaginal sling

Keywords: cystocele uterine prolapse urinary incontinence
effect of vision therapy in myopic children with poor accommodative response

Conditions: Myopia

Summary: this study aims to determine the treatment effect of vision therapy on myopic children by assessment of accommodative function before and after therapy.

1. specific aims of the proposed clinical trial: 1.1 to provide a definitive proof that vision therapy (vt) can improve the accommodative function of myopic children by comparing the results from treatment group to placebo group. 1.2 to minimize the influences of confounding variables by randomly assigning the intervention. 1.3 to observe the longitudinal effects of vt on accommodation system and its effect on axial length. 2. hypothesis: vt can improve the accommodative functions of 8-12 years old chinese myopic children with poor accommodative response.

Eligibility criteria:
inclusion criteria: subjects enrolled in the trial must: * be within the age range of 8 to 12 years old inclusive * -0.75d to -4.50dspherical equivalent by cycloplegic autorefraction in both eyes * astigmatism≤1.5d in both eyes * anisometropia≤1.0d * monocular accommodation lag at near(33cm)in right eye by non-cycloplegic autorefraction≧1d * have vision correctable to at least 0.8 or better in each eye. exclusion criteria: subjects enrolled in the trial must not have: * current or prior use of pals, bifocals, or contact lenses in either eye( prior or current use of svls allowed) * history of any of the following functional defects: strabismus, amblyopia, nystagmus * history of diabetes or seizures * history of any ocular systemic, or neuro-developmental condition that might influence refractive development * use of ocular or systemic medications containing atropine, pirenzepine, and anti-epileptic medications in recent 3 months * history of any ocular surgery that might influence refractive development * developmental disability, attention deficit hyperactivity disorder(adhd), or learning disability diagnosis in children that in the investigator's discretion would interfere with office-based treatment * relocation anticipated for 1 year * birth weight lower than 1250 grams（2lbs,12oz） * siblings in the study.
renji cerebral small vessel disease corhort study

Conditions: Cerebrovascular Disorders; Cognition Disorders

Summary: we aim to make clear the impact with the mechanisms of variant pathological injuries on the outcomes of csvd, to find independent imaging markers and establish prediction model of it.

a cohort of post stroke cerebral small vessel disease (csvd) patients with different cognitive status are consecutively recruited in this study. detailed full domain cognitive assessment and multi-modal mri (including brain morphology , dti indices, microbleed counts, brain volumes as well as brain network characters, etc.) are performed. cognitive states(including attention-executive function, memory, language, visuo-spatial and global cognition with the transition to dementia) and the overall prognosis (cardiovascular events, stroke recurrence, death due to cardiovascular event and all cause death) are longitudinally followed up. the correlations between baseline and followed mri parameters with the outcomes are analyzed in order to make clear the impact with the mechanisms of variant pathological injuries on the outcomes of csvd, to find independent imaging markers and establish prediction model of it.

Eligibility criteria:
inclusion criteria: * ①50-85 years; ② at least 6 years of education; ③ csvd was defined as patients experienced a clinical lacunar stroke at least 1 months ago, and mri showed responsible lacunar infarcts and white matter lesions; ④ cooperate with cognitive tests; ⑤not accept medications that affect cognition; ⑥. score of modified rankin scale ≦3; ⑦. sign informed consent. exclusion criteria: * ① etiology due to cardioembolic or large vessel disease (\>50% stenosis in extra- or intra-cerebral arteries); ② non vasular white matter lesions(wmls)；③ cortical and/or cortico-subcortical non-lacunar infarct; ④ other cognitive diseases (such as alzheimer's disease, parkinson disease or thyroid disease, etc. ) ⑤severe systemic diseases such as heart, liver and kidney diseases or major psychiatric disorders; ⑥severe depressive state: hamilton depression rating scale score \>24; ⑦ mri contraindications.
brain uptrain to improve learning and development

Conditions: Term Infant; Late Preterm Infant

Summary: the purpose of this study is to see if an early literacy and developmental program in addition to shared reading can increase developmental test scores at 24 months of age. all caregivers of infants in this study will receive shared reading training. half of the caregivers will be trained in an additional coach-led caregiver-implemented early literacy and numeracy program. information related to infant development will be collected from parent surveys, medical records, and questionnaires and assessments.

this study will test the hypothesis that in term or late preterm infants who are discharged home from the newborn nursery, a coach-led caregiver-implemented early literacy and developmental program in addition to shared reading, compared with shared reading alone, will increase the ages and stages questionnaire® score at 24 months. this will be a double blind randomized controlled trial with 1:1 parallel allocation using stratified permuted block design. randomization will be stratified by gestational age (≥ 35 to \<38 weeks and ≥ 38 weeks). randomization of twins and higher orders (when eligible) will be to the same group. term and late preterm infants ≥ 35 weeks' gestation admitted to the newborn nursery are eligible for inclusion if they are being discharged home. we will exclude infants admitted to the nicu, infants with a known syndrome or major malformation, infants in dhr custody, infants enrolled in a competing study, and infants of families with a primary language other than english or spanish. all study participants will receive shared reading information at scheduled well-child checks. caregivers of infants in the intervention group will receive additional coach-led caregiver-implemented early literacy and developmental program. we will complete an asq-3 online or by telephone at 12 months, 24 months, and 36 months. we will also measure early literacy at 3 years, 4 years, and 5 years. the primary outcome will be the asq-3 scores at 24 months.

Eligibility criteria:
inclusion criteria: inborn at uab, delivered at more than 35 weeks' gestation, planned for discharge home after initial hospitalization. - exclusion criteria: a major malformation, a known syndrome, admitted to the nicu, in dhr custody, enrolled in a competing study, and family's primary language is other than english or spanish. -

Keywords: maternal training cognitive scores reading literacy numeracy
help arthritis with exercise in west virginia

Conditions: Arthritis

Summary: the purpose of this project is to determine if an evidence-based, community-delivered physical activity program, enhancefitness, yields benefits for participants with arthritis. the 3-year project will: 1) conduct a meta-analysis of community-based exercise programs for adults, 2) implement and evaluate the enhancefitness program in west virginia using a randomized, controlled (wait list) design, and 3) disseminate the results to community and public health partners. it is anticipated that participation in the enhancefitness program will result in reduced pain, improved physical function and physical activity levels for adults with arthritis.


Eligibility criteria:
inclusion criteria: * age 18 and older * any type of self-reported, doctor-diagnosed arthritis exclusion criteria: * any co-existing conditions where exercise is a contraindicated * impaired cognitive status * non-ambulatory

Keywords: arthritis osteoarthritis rheumatoid arthritis fibromyalgia lupus
legs dysmetria in total hip replacement: does hip approacches and navigation decrease the risk?

Conditions: Hip Osteoarthritis

Summary: the purpose of this study is to collect clinical and radiological data from the case series of patients surgically treated with total hip arthroplasty at the rizzoli orthopaedic institute. the primary objective is to evaluate in terms of safety and efficacy the reduction of legs dysmetria and proper acetabular cup inclination intraoperatively when comparing anterior, direct lateral, and postero-lateral hip approaches conducted via traditional or navigation-assisted surgery. the secondary objectives of the study are to evaluate, by comparing navigation-assisted and non-navigation-assisted hip approaches, intraoperatively the correct positioning of the prosthesis by analyzing the acetabular cup version; surgical timing; and number of intraoperative radiographs taken. in addition, the accuracy of preoperative planning will be assessed and a clinical evaluation performed during a follow-up of one year.


Eligibility criteria:
inclusion criteria: 1. age between 50 and 80 years; 2. signs and symptoms of hip osteoarthritis (pain intensity of at least 6 points of visual analogic scale pain - 0-10 scale in the previous week); 3. radiographic signs of hip osteoarthritis (grade 3-4 according to tonnis classification); exclusion criteria: 1. patients unable to express consent; 2. patients undergoing previous ipsilateral hip surgery; 3. patients undergoing lower limb surgery to be treated in the previous 12 months; 4. patients with malignant neoplasms; 5. patients with rheumatic diseases; 6. patients with uncontrolled diabetes; 7. patients with uncontrolled thyroid metabolic disorders; 8. patients abusing alcoholic beverages, drugs or medications; 9. body mass index \> 35; 10. pregnant and/or fertile women. 11. pain intensity less than 6 points in accordance with the visual analogic scale scale. 12. patients with the presence of excessive deformity resulting from acetabular or femoral head dysplasia 13. patients who have already undergone total hip arthroplasty surgery on the affected hip. 14. previous extensive surgery of the reference joint (osteotomy around the hip, open or arthroscopic osteochondroplasty for femoral-acetabular conflict).
the effect of remote ischemic preconditioning applied in children the day before open heart surgery

Conditions: Congenital Heart Disease

Summary: the study research is to analyse brief episodes of limb ischemia applied to children the day before open heart surgery as protection from myocardial injury induced by extracorporeal circulation.

children undergoing repair of congenital heart defects were randomized to ripc (remote ischemic preconditioning) or control treatment. ripc was induced by four 5-minutes cycles of lower limb ischemia and reperfusion using a blood pressure cuff. measurements of troponin i, brain natriuretic peptide, interleukines 8 and 10, real time pcr to nfkb and clinical parameters were obtained and compared postoperatively (4, 12, 24 and 48 hous after).

Eligibility criteria:
inclusion criteria: * 1 month to 2 years age * waiting for open heart surgery in hospital * 2008, january to march * rachs-1, except the 1 category exclusion criteria: * genetic syndromes * infected children * immunodeficiency * immunosuppressor use * no parents permission

Keywords: ischemic preconditioning congenital heart disease
switching from efavirenz/atripla to rilpivirine among patients with neurocognitive or neuropsychological side effects

Conditions: Impaired Cognition; Depression/Anxiety; Poor Quality Sleep; Quality of Life; HIV-1 Infection

Summary: despite long-term use in clinical practice, chronic treatment with efavirenz (efv) has been associated with persistent central nervous system symptoms or mild or even asymptomatic neurocognitive impairment. whether switching to rilpivirine (rpv) containing regimen is beneficial among patients who experience mild or asymptomatic neurocognitive/neuropsychiatric adverse events during efv has not been explored yet. the proposed pilot study will examine whether switching from single tablet regimen tdf/ftc/efv to single tablet regimen tdf/ftc/rpv is associated with neurocognitive/neuropsychiatric improvement among hiv-infected patients with mild/asymptomatic neurocognitive impairment or neuropsychiatric symptoms during efv-containing antiretroviral treatment. patients under stable treatment with tdf/ftc/efv, confirmed hiv-1 rna viral load \< 50 copies/ml and altered scores in depression, quality of sleep or anxiety tests and/or alteration in 1 or more domains as assessed by neuropsychological assessment, will be randomized to immediate or deferred (24 weeks) switch to tdf/ftc/rpv. neurocognitive and neuropsychiatric tests will be repeated after 12, 24 and 48 weeks of follow-up and variations will be compared between groups.


Eligibility criteria:
inclusion criteria: * age ≥18 years old and ability to sign informed consent * continuative treatment with tdf/ftc/efv for ≥180 days * hiv-1 rna viral load \< 50 copies/ml in two consecutive determinations (including screening) * no history of treatment failure and/or evidence of any mutations associated with resistance to nrti or nnrti * no contraindication to treatment with study drugs * any one of the following conditions: (i) altered scores in depression, quality of sleep or anxiety tests (ii) alteration in 1 or more domains as assessed by neuropsychological assessment exclusion criteria: * ongoing treatment or predictable need of treatment with proton pump inhibitors * new aids defining condition diagnosed within the 21 days prior to screening * previous diagnosis of aids dementia complex * current alcohol or substance dependence * major psychiatric disorders * decompensated cirrhosis * plasma creatinine \>1.2 mg/dl or estimated glomerular filtration rate \<60 ml/min (mdrd formula) * ast, alt or plasma bilirubin \>3 times upper limit of normal * any other clinical condition or prior therapy that would make the subject unsuitable for the study or unable to comply with the dosing/food requirements
meditation and cancer, pilot feasibility study (maeva pilot study)

Conditions: Breast Cancer; Prostate Cancer

Summary: maeva, which stands for meditation, acceptance and commitment towards values, is an open and circular program, made up of 3 themed sessions, following a weekly rhythm. it is proposed here to study this program over a period of 3 months, which will give participants the opportunity to complete up to three complete cycles. this program is based on the practice of and the processes of acceptance and commitment therapy. these approaches, used for several years, have proven their effectiveness in the management of stress, chronic anxiety, insomnia, chronic pain, distress in the face of chronic disease, as well as in the prevention of depressive relapses and management of impulsivity. unlike conventional 8-week meditation programs, the maeva program allows patients to enter the study at any stage of the disease (within, outside the exclusion criteria) and from any session and to participate according to their possibilities. the patient can participate in a weekly session of the program for 3 cycles. during the sessions, it will be proposed to train meditative practices and 3 different themes will be addressed (one theme per session): meditation, acceptance and commitment to values. .


Eligibility criteria:
inclusion criteria: * major patient * patient with non-metastatic prostate or breast cancer * newly diagnosed patients or those undergoing treatment * patient able and willing to follow all study procedures in accordance with the protocol. * patient having understood, signed and dated the consent form. * patient affiliated to the social security system * patient able to remain in a sitting position during the 2-hour session exclusion criteria: * impossibility to undergo the medical follow-up of the trial for geographical, social or psychological reasons. * presence of an acute psychiatric disorder: depression in acute phase, unstabilised bipolar disorder, psychotic disorders (delusions, hallucinations), etc. * presence of recurrent uncontrolled panic attacks (notably linked to hypochondriac concerns) * presence of latent or patent post-traumatic stress disorder * lack of motivation to meditate * insufficient attentional resources to meditate: major problems with attention, memory or reasoning * patient with metastatic cancer. * presence of cognitive and neurocognitive disorders and deficits * presence of deafness * membership in a meditation programme prior to inclusion

Keywords: mindfulness quality of life cancer open and circular program meditation