Kornimate/medical-research-clean huggingface dataset:
obstructed defaecation: proctography versus ultrasound in symptomatic patients

Conditions: Obstructed Defaecation Syndrome

Summary: obstructed defaecation syndrome is a common problem in which patients experience difficulty to evacuate stools and feel that the bowel is incompletely empty, which causes the need to put fingers in to the rectum or vaginal to empty the rectum. these symptoms have a significant effect on social, physical, emotional and sexual wellbeing all of which have impact on quality of life. these symptoms are caused by posterior compartment disorders such as the last part of the large bowel bulging into the vagina (rectocele), the small bowel pressing on the rectum (enterocele), a circumferential infolding of the rectal wall (intussusception) or paradoxical pelvic floor contraction during attempts to evacuate (anismus). currently the evacuation proctogram is the gold standard for diagnosis of posterior compartment disorders. this technique, however, exposes the patient to ionising radiation, requires preparation of the small and large bowel with contrast and defaecation in a non-private setting, which most women find embarrassing and unpleasant. over the years, research has focussed on identifying alternatives that are better tolerated to substitute evacuation proctography. ultrasound is a widely available, non-expensive, non-invasive, fast and a well-tolerated method for the dynamic and static imaging of the pelvic floor without the use of ionising radiation. the level of agreement between transperineal ultrasound (tpus) and proctography for varies widely. endovaginal ultrasound (evus) not yet compared to proctography. the aim of this study is to assess the level of agreement between ultrasound (evus and tpus) and evacuation proctography in the diagnosis of posterior compartment disorders.


Eligibility criteria:
inclusion criteria: * female patients * symptoms of obstructed defaecation * planned for evacuation proctography exclusion criteria: * inability to understand english * unwilling to consent for evacuation proctography * under 18 years of age * virgo intacta

Keywords: obstructed defaecation syndrome transperineal ultrasound endovaginal ultrasound evacuation proctography
multidimensional assessment of fatigue in multiple sclerosis- observational study - ticino

Conditions: Multiple Sclerosis

Summary: fatigue is a common symptom in patients with multiple sclerosis, however, its nature is not completely understood. fatigue overlaps often with other symptoms such as somnolence, depression and cognitive disorders, from which it is not always readily distinguished. the evaluation of fatigue and the three most frequently associated symptoms using a multidimensional approach might allow to understand, which methodology is the best indicated to estimate the prevalence of fatigue with greatest accuracy, leading to a better differentiation of the symptoms in the diagnostic setting.

objectives: 1- to provide a detailed characterization of fatigue in a cohort of selected ms patients, including a definition of the boundaries and the overlaps between fatigue, somnolence, mood disorders and attention dysfunction; 2- to see how the prevalence and the overlaps between fatigue, somnolence, depression and attention dysfunction are influenced by the method of assessment. 3-to better characterize the sleep structure in ms patients with fatigue under both the macro- and microstructural point of view.

Eligibility criteria:
inclusion criteria: * definite diagnosis of ms (14,15) or cis (16);according to the most recent standard criteria * expanded disability status scale (edss) score \< 7.0 (17); * last magnetic resonance imaging (mri) within the previous 12 months; * male or female; * \>18 years old; * willing to perform the study procedures; * signed informed consent. exclusion criteria: * mini mental status examination (mmse) score \< 24; * relapse within the last 3 months; * radiologically isolated syndrome (ris); * history of drug and/or alcohol abuse; * any serious general medical condition like decompensated cardiopulmonary disease, cancer or decompensated renal failure, as well as any neurological condition (other than ms) that can interfere with the correct execution of the study design.

Keywords: multiple scerlosis fatigue sleep somnolence depression cognitive disorders
china advate ptp study

Conditions: Hemophilia A

Summary: the purpose of this study is to assess efficacy, safety and pharmacokinetics of advate in the treatment and prevention of bleeding episodes (bes)


Eligibility criteria:
main inclusion criteria: * ethnic chinese * is of any age * has a documented diagnosis of severe or moderately severe hemophilia a (congenital fviii deficiency: baseline factor viii (fviii) ≤ 2%) * has documented and verified \>50 exposure days (eds) to fviii (recombinant or plasma derived) * is receiving on-demand treatment with fviii at the time of enrolment in this study * has negative history of inhibitor development * is hiv negative or hiv positive with stable disease and cd4+ count ≥ 200 cells per mm\^3 * is negative for hepatitis c virus (hcv); or participant is hcv positive with chronic stable hepatitis as assessed by investigator main exclusion criteria: * has prior history of hypersensitivity or anaphylaxis associated with receipt of fviii * is diagnosed with other bleeding disorder(s) other than hemophilia a, including but not limited to thrombocytopenia (platelet count \< 100000 /ml) * has been exposed to an investigational product (ip) within 30 days prior to the screening visit or is scheduled to participate in another clinical study involving an ip or investigational device during participation in the study * is planned, or likely to have surgery during the study period * has end-stage renal failure or evidence of a severe or uncontrolled systemic disease as judged by the investigator * has active hepatic disease (alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels \> 5 times the upper limit of normal) * has clinical or laboratory evidence of severe liver impairment including (but not limited to) a recent \& persistent international normalized ratio (inr) \>1.4, and/or the presence of splenomegaly and/or significant spider angioma on physical exam, and/or a history of esophageal hemorrhage or documented esophageal varices * is a family member of the investigator or site staff
kentucky access to recovery evaluation

Conditions: Substance Use Disorders; Treatment Adherence and Compliance

Summary: evaluate the long-term effectiveness of implementing vouchers as a linkage strategy in a population requiring recovery support services (rss) when no other funding sources are available. a within-subjects study design will be used to test the effectiveness of the kentucky access to recovery (katr) last resort voucher linkage approach to reduce the risk of nonfatal and fatal overdoses by (a) increasing an individual's recovery capital; (b) reducing resumption of illicit substance use; and (c) promoting relinking to rsss if illicit substance use is resumed.


Eligibility criteria:
inclusion criteria: * be in sud treatment or have completed within the past year sud treatment for opioid use disorder or stimulant use disorder or have a history of overdose from opioid use * be a first-time participant in katr * be in early stages of recovery (less than one year in recovery) * be a resident of a katr service county * be at or below the 200% federal poverty level * not have financial resources available through other funding mechanisms for rsss * be 18 years of age and older * be in need of recovery supports that will enhance their likelihood of staying in recovery exclusion criteria: * under 18 * participated in katr previously

Keywords: support services recovery opioid overdose addiction social services appalachia
safety and efficacy of long-term treatment with atorvastatin in patients with primary biliary cirrhosis

Conditions: Primary Biliary Cirrhosis; Hypercholesterolemia

Summary: primary biliary cirrhosis (pbc) is frequently associated with hypercholesterolemia and possibly with an increased cardiovascular morbidity and mortality. statins lower serum cholesterol levels and may thus improve the cardiovascular risk in pbc patients. the aim of our study therefore was to prospectively examine the efficacy of low-dose atorvastatin on indicators of cardiovascular risk such as dyslipidemia and vascular function as well as safety in patients with pbc.

primary biliary cirrhosis (pbc) is often associated with abnormalities in serum lipids. hypercholesterolemia is an established risk factor for cardiovascular morbidity and mortality. since many pbc patients have a very slow progression of their underlying liver disease cardiovascular risk factors may become more relevant as prognostic facors. whether statins lower serum cholesterol levels and reduce the cardiovascular risk in pbc patients remains to be determined. statins are generally well tolerated and are not associated with an increased risk of hepatotoxicity in patients with nonalcoholic fatty liver disease (nafld). however only limited data on safety on statins in chronic cholestatic liver diseases are available. in a recent pilot study at the medical university of graz atorvastatin did not statistically increase liver enzymes in pbc patients. however, data on long-term treatment with atorvastatin in these patients are not yet available. moreover, long-term treatment with statins may have potential beneficial immunomodulatory effects on the disease course of pbc in analogy to other immune-mediated disorders such as rheumatoid arthritis and multiple sclerosis.

Eligibility criteria:
inclusion criteria: * ldl-cholesterol \> 130 mg/dl * primary biliary cirrhosis (ama positive or biopsy proven) * male or female gender * age 18-70 years * normal kidney function exclusion criteria: * primary biliary cirrhosis stage iii-iv (ludwig score) * liver cirrhosis * decompensated liver disease ( \> child-pugh class b, ascites, esophageal varices) * alt or ast \> 2x uln * pregnancy or breastfeeding * premenopausal women without certain contraception * known hypersensitivity to hmg-coa reductase inhibitors * current treatment with lipid-lowering agents other than atorvastatin; immunosuppressants, macrolides

Keywords: cholestasis atherosclerosis statins vascular function
comparative evaluation of the effect of different adjunctive air polishing powders in nonsurgical periodontal therapy in patients with stage ii and iii periodontitis

Conditions: Periodontitis

Summary: the aim of this clinical trial is to evaluate and compare the effect of a newly designed air-polishing device (apd) using erythritol, glycine, and trehalose air-polishing powders in nonsurgical periodontal therapy with control (conventional scaling and root planning) following the concept of guided biofilm therapy (gbt) as an adjunctive to subgingival instrumentation (si) in nonsurgical periodontal therapy for stage ii and iii periodontitis patients both clinically and microbiologically.


Eligibility criteria:
inclusion criteria: 1. individuals of both sexes with an age between 30 and 65 years, having at least 16 natural teeth in function, 2. stage ii and iii (moderate to severe) periodontitis, having at least 16 teeth with the need for si 3. interproximal plaque index (api) ≤ 35%; patients with good oral hygiene. 4. no history of systemic disease that may influence periodontal disease exclusion criteria: 1. pregnancy or breastfeeding, 2. smokers with more than seven cigarettes per day 3. patients that had a treatment with antibiotics within six months before the study 4. need for periodontal surgery or adjunctive antibiotic treatment to the si 5. patients who had any periodontal treatment during the last year before the study. 6. patients with known systemic or autoimmune disease.

Keywords: gbt periodontitis si
reflexology: an intervention for acute myeloid leukemia(aml) patients

Conditions: Acute Myeloid Leukemia

Summary: the aim of this study is to test a complementary therapy intervention (reflexology) that will assist in improving quality of life (qol) for patients undergoing chemotherapy for acute myeloid leukemia. within the context of conventional medical care. quality of life will be assessed via intermediate indicators: 1) physical indicators (greater physical functioning, lower presence of symptoms) 2) emotional indicators (greater spirituality, lower anxiety, and lower depressive symptomology); by a specific questionnaire. 3) chemotherapy side effects associated with the digestive system.

the goal of this study is to test a complementary therapy intervention that will assist in improving quality of life (qol) for patients undergoing chemotherapy for acute myeloid leukemia within the context of conventional medical care. this open study will test a one group design in which participants will continue to receive conventional care. all patients will receive reflexology (a specialized foot therapy) from a certified reflexologist twice weekly from the beginning of chemotherapy treatment. the specific aims are: 1) to evaluate the effect of reflexology treatment on chemotherapy side effects effecting the digestive system. 2) to evaluate the effect of reflexology treatment on quality of life. the assessment of the treatment will be executed on the facit-d version 3.the influences of the treatment will also be evaluated by the nursing staff, in order to describe the patient's mental health and the condition of his intestinal movement.the side effect before during and after the chemotherapy treatment will be compared using the questionnaire.

Eligibility criteria:
inclusion criteria: * diagnosis of aml * chemotherapy treatment * signing a consent form. exclusion criteria: • not willing to sign a consent form.

Keywords: acute myeloid leukemia, reflexology
efficacy of epoetin alfa in patients with friedreich's ataxia

Conditions: Friedreich's Ataxia

Summary: friedreich's ataxia is a rare genetic disorder characterized by severe neurological disability and cardiomyopathy. friedreich's ataxia is the consequence of frataxin deficiency. although several drugs have been proposed, there is no available treatment. it was recently demonstrated that erythropoietin can increase the intracellular levels of frataxin in an in-vitro model. the present project is aimed at testing the possible therapeutic approach of erythropoietin, which is an already available and commercialized drug. the investigators will perform both in-vitro and in-vivo tests, in order to asses its efficacy and safety in patients. the results will be useful to plan further clinical trials.

friedreich ataxia (frda) is an inherited recessive disorder characterized by progressive neurological disability. frda is the consequence of frataxin deficiency. although several drugs have been proposed for frda, there is no available treatment. recently it was shown that recombinant human erythropoietin (rhu-epo) administration increases frataxin expression in cultured human lymphocytes of frda patients. it is therefore of primary importance to test extensively rhu-epo's ability in increasing frataxin levels in-vitro and in-vivo. in addition rhu-epo is an already available and commercialized drug approved for the treatment of anaemia associated with chronic renal disease, heart failure and cancer. towards this overall purpose, we will perform an acute clinical trial in frda patients with rhu-epo and will assess its effect in-vivo on frataxin expression. in addition, rhu-epo's safety in frda patients based on laboratory parameters and neurological indexes will be tested. the results will be useful to gain new insight in the role of rhu-epo in frda, and in the future, it may be useful to plan further clinical trials.

Eligibility criteria:
inclusion criteria: * molecular diagnosis of fa based on a homozygous gaa expansion within the frda with a triplet repeat sequence in the pathological range. * age \>18, \<50 years exclusion criteria: * failure to meet one of the inclusion criteria * patients in treatment with idebenone * wheelchair bound patients * significant renal, hepatic or haematological disease * positive history for arterial or venous thrombosis * acute diseases that might interfere with the study * positive history for arterial hypertension * present or programmed pregnancy * known hypersensitivity to study drug * other unacceptable concomitant medications (in particular agents thought to have a neuroprotective potential as tocopherol, amantadine, memantine, free radical scavengers).

Keywords: frda erythropoietin epoetin alfa
prevalence of knowledge, attitudes and perception of covid vaccine in iraq. a cross sectional study

Conditions: COVID-19; Sars-CoV-2 Infection; COVID-19 Pandemic

Summary: numerous scientific agencies and iraqi moh has advised to promote population vaccination as an attempt to reduce the burden of covid19. the aim of our study is to evaluate knowledge, attitude, practice and concerns toward different type of covid19 vaccine of iraqi population. this will help us concentrate our efforts to increase willingness of vaccination among southren iraqi people

detailed description: new human pandemic disease that have large of world population concern and have many challenges that effect on their life directly or indirectly is coronavirus infection (covid 19).numerous scientific agencies and iraqi moh has advised to promote population vaccination as an attempt to reduce the burden of covid19 so need to evalute knowledge, attitude, practice and concerns toward different type of covid19 vaccine of iraqi population to increase willing of vaccination among southren iraqi population to reduce mortality rate of covid19 and searching for incidence vaccination against it. so to decrease complication of covid19 pandemic, they introduced covid19 vaccine that has essential role to maintain our life. so many companies of manufacturing of covid19 vaccine with different ways by using part of viruses spike of protein or whole virus after attenuated but some iraqi population hesitancy that delay of acceptance in spite of this vaccination is represent one of method to protect themselves from infected with covid19 in addition attended social event ,shaking hands ,leaving place when talking with other person and still wearing of mask. important recognition key for prevention and maintain our life is attitude judgment and how to do this to give positive or negative idea about covid19vaccine according to different source of information that concerning like social media ,experience of previous personal , governmental information and health care professional sources considering lake of studies and research related to covid19 vaccine in iraq ,so there is urgent need to know refused or hesitant attitude in southern iraqi population

Eligibility criteria:
inclusion criteria: * willingness to participate in the study * living in southern iraq exclusion criteria: * less than18 years * not willing to complete the questionnaire * unable to complete the questionnaire

Keywords: vaccine
antibiotic-loaded cement versus non-antibiotic-loaded cement in hip prosthesis surgery for proximal femur fractures

Conditions: Proximal Femoral Fractures

Summary: the study aims to determine if antibiotic-loaded cement reduces post-surgery infection rates compared to non-antibiotic cement. the trial involves 450 elderly patients with specific hip fractures, assessing infection incidence, implant stability, and associated costs. this randomized, blinded study is conducted by irccs ospedale san raffaele.


Eligibility criteria:
inclusion criteria: * patients must be older than 65 years * fracture type: the study includes patients with medial femoral neck fractures classified as ao type b1, b2, and b3, indicating specific types of hip fractures. * surgical indication: patients should have an indication for prosthetic hip surgery. * informed consent: patients must provide signed informed consent to participate in the study exclusion criteria: * fracture type: exclusion of patients with trochanteric region fractures and femoral head fractures (ao classification types a and c), periprosthetic fractures, patients with multiple traumas or multiple fractures. * blood test anomalies: patients with pre-operative blood test anomalies, such as ionic disorders and hemoglobin levels lower than 8 g/dl. * renal insufficiency: patients with renal insufficiency. * active infections: exclusion of patients with active infections or suspected/confirmed hypersensitivity or allergy to gentamicin, history of toxicity or reaction to aminoglycosides.
influence of nutritional indices on the prognosis of patients with sars-cov-2 infection

Conditions: COVID-19

Summary: with the decline of virulence after the mutation of the sars-cov-2 , based on the national life and health and national development needs, the domestic sars-cov-2 infection epidemic prevention policy has changed, and the number of people infected by the sars-cov-2 has increased. nutritional status is an indicator of human health and plays an important role in fighting disease. malnutrition has been found to correlate with prognosis in patients infected with the sars-cov-2 infection . timely identification and assessment of the patient's nutritional status and early implementation of relevant nutritional intervention are conducive to the recovery of the patient's condition. in clinical practice, it is necessary to improve nutrition as an aspect of the comprehensive diagnosis and treatment of patients with sars-cov-2 infection, but there is still a lack of relevant nutritional indicators or models to simply and accurately assess the nutritional status of patients.the purpose of this study was to evaluate the effects of pni, nri, gnri, albumin level, vitamin d, chest muscle area and density on the clinical characteristics and prognosis of patients with sars-cov-2 infection, to find the nutritional predictors of severe disease in patients with sars-cov-2 infection, and to establish a simpler and more accurate nutritional evaluation model. to provide evidence for targeted nutritional interventions in patients with sars-cov-2 infection.

patients with sars-cov-2 infection attending the second affiliated hospital of chongqing medical university were included in the retrospective study. participants met the inclusion and exclusion criteria. data to be collected include age, sex, height, and weight at initial treatment; blood routine, liver function, kidney function, coagulation function, electrolytes, vitamin d, c-reactive protein, ferritin; ct and mri information; underlying diseases, complications, treatment options, etc. follow up patients until discharge or death. after the data collection, statistical methods such as chi-square test and logistic regression analysis were used to evaluate the impact of nutritional factors on the prognosis of patients infected with sars-cov-2 infection.

Eligibility criteria:
inclusion criteria: patients with a positive sars-cov-2 nucleic acid test or a positive sars-cov-2 antigen test. exclusion criteria: 1. people with end-stage malignant tumors; 2. nutritional intake disorders, mainly dependent on enteral and parenteral nutrition supporters; 3. paralyzed; 4. intravenous drug addicts.

Keywords: prognostic nutritional index geriatric nutritional risk index pectoralis muscle index prognosis