Kornimate/medical-research-clean huggingface dataset:
feeding america intervention trial for health--diabetes mellitus

Conditions: Diabetes Mellitus

Summary: the feeding america intervention trial for health-diabetes mellitus (faith-dm) is a randomized, controlled study of the implementation of a diabetes intervention in food pantry settings.

for adults with diabetes mellitus, diabetes self-management education (dsme) is critical to achieving long-term control of blood sugar levels (glycemic control) and preventing diabetes-associated complications. this education is often difficult to access for highly vulnerable and marginalized adults in the united states. furthermore, foods for a diabetic diet are often out of reach for food insecure households. the purpose of this study is to determine the extent to which food banks and food pantries can help reach this population with effective dsme, food, and access to primary health care. the investigators' primary outcome of interest is hba1c improvement in the intervention group compared to a wait-listed control group of food pantry clients living with uncontrolled type 2 diabetes.

Eligibility criteria:
inclusion criteria: * food pantry client at one of three participating food banks: alameda county community food bank (oakland, ca), gleaners community food bank of southeastern michigan (detroit, mi), houston food bank, (houston, tx) * type ii diabetes mellitus with hba1c ≥ 7.5% using food bank point-of-care testing * reliable mode of contact (either phone or address) * english or spanish verbal fluency * 18 years of age or older * intent to remain in the study area for at least the next 12 months * willingness to participate in intervention exclusion criteria: * type 1 diabetes * pregnant or less than 6 weeks post-partum * cognitively impaired: dementia, mental illness, or active substance abuse severe enough to interfere with administration of the survey or participation in the intervention * household member already enrolled in the study

Keywords: diabetes mellitus community intervention intervention randomized dietary intervention self-management support food bank
apolipoprotein d (apod) in human serum as marker of parkinson's disease

Conditions: Parkinson's

Summary: in italy affected people are 200,000 and every year parkinson new cases are 10,000. aging is the principle risk factor of parkinson with the possibility of its development doubling every five years after 65. because of the increase of the social longevity and aging as the main risk factor, there are many repercussions on the health system (hospital stays and pharmaceutical costs) as on the social system (assistance- related problems). parkinson's disease exerts an extremely negative impact on life's quality of the patient. in fact, because of parkinson symptoms (tremor, dribble, etc), patient's social life will be reduced with the consequent development of the depression. consequently, the early detection and treatment of parkinson's is necessary. to achieve this goal, apolipoprotein d (apod) in human serum as a marker of the oxidative stress-inflammation vicious cycle seems most promising candidate for diagnosis.

total participants: n=180. study part 1: health persons: n=90; groups of health persons: n=3; subjects per group: n=30. study part 2: patients: n=90; groups of patients: n=3; subjects per group: n=30.

Eligibility criteria:
inclusion criteria: * patients with parkinson's disease in the pathological related stages (hoehn and yahr) * persons \> 20 years exclusion criteria: * patients with a neurodegenerative disorder different to parkinson's disease * patients, who are post-ictus and/or traumatic brain injury (tbi) * patients, who are treated with antipsychotic drugs * obese persons (bmi \> 27) * idiopathic normal pressure idrocephalus (inpi) * paget's disease * breast cancer * adenocarcinoma of the prostate * glucose-6-phosphate (gsd-i) deficiency * insuline-resistance-related disorders
construction of perioperative medical data platform and its typical practice to predict postoperative acute moderate to severe pain with machine learning models

Conditions: Anesthesia; Acute Pain; Risk Reduction

Summary: data intelligence platform was widely used to facilitate the process of clinical research. however, a platform that integrates natural language processing (nlp) and machine learning (ml) algorithms has not been reported in perioperative medical management.


Eligibility criteria:
inclusion criteria: * patients were included if they were above 18 years old, undergoing non-local anesthesia surgery. exclusion criteria: * the basic information such gender, age, height, weight, and body mass index (bmi) were missing. * patients undergoing day surgery, with a history of multiple operations, or entering icu after surgery, and losing the nrs score during movement at 24h after surgery.

Keywords: data platform machine learning postoperative acute pain
non-invasive diagnosis of pulmonary embolism by use of biomarkers in exhaled breath condensate

Conditions: Pulmonary Embolism

Summary: in this study, a new, non-invasive method for diagnosis of pulmonary embolism (pe) will be tested. in pre-clinical studies, we have identified 151 putative biomarkers for pulmonary embolism in the exhaled breath condensate (ebc). these biomarkers needs validation/consolidation in a clinical setting before further test of this new diagnostic method.

the study will compare the protein profiles of ebc collected from patients admitted to the department of cardiology with suspected pulmonary embolism and controls with same age (within a range of 10 years) and gender from the outpatient clinic awaiting elective cardiovascular surgery. the main-outcome (i.e. means of the relative amounts of specific proteins in the ebc samples) will be compared by unpaired t-tests after assessment of normality and standard deviations within the three groups (pe confirmed, pe suspected but not confirmed and controls). furthermore, sensitivity and specificity will be calculated for relevant proteins. the results from analysis of ebc samples from the patients and controls will be compared with results from the porcine model in order to confirm and reduce the number of putative biomarkers for pe. blood samples (i.e. excess plasma from routine blood samples drawn as a part of routine diagnostic work-up) from the study participants will be stored for standardization of the putative markers and verification and supplementing analysis of the ebc markers. in order to qualify the most suitable markers and substrates for standardization, the analysis of the ebc samples must be completed before the blood samples can be analyzed. only biochemical, no genetic analysis will be conducted.

Eligibility criteria:
inclusion criteria - suspected/confirmed pe patients: * admitted to the emergency department with initial diagnosis of pe, visited to the department of cardiology at aalborg university hospital. * are conscious and able to understand the given study information. * possess legal capacity. * age above 18 years. * informed, signed consent is obtained. * clinically stable, which is defined as patients with stable blood pressure and not in need for other treatments . * no need for organ support, which comprises need for vasopressors or inotropes, mechanical ventilation, extra corporal circulation or renal replacement therapy. inclusion criteria - controls: • patients as the pe patients, but where the diagnosis of pe is rejected. the rest of the control persons will be recruited as described: * patients who are going to have elective procedures at the department of cardiology, aalborg university hospital. * same gender and age (within a 10-year range) as an included pe patient. * are conscious and able to understand the given study information. * possess legal capacity. * age above 18 years. * informed, signed consent is obtained. exclusion criteria: * active malignant disease (i.e. ongoing anti-cancer therapy or palliation). * current smokers
cortical excitability in cyclic vomiting syndrome

Conditions: Cyclic Vomiting Syndrome

Summary: this exploratory study will determine if there are differences in cortical excitability between patients suffering from cyclic vomiting syndrome (cvs) and healthy control subjects, as assessed by a non-invasive method of brain stimulation (transcranial magnetic stimulation, tms).

this exploratory study will determine if there are differences in cortical excitability between patients suffering from cyclic vomiting syndrome (cvs) and healthy control subjects, as assessed by a non-invasive method of brain stimulation (transcranial magnetic stimulation, tms). using the paired-pulse tms paradigm, intracortical inhibition and facilitation of cortical circuitry will be assessed by stimulating the motor cortex and using the electromyographic (emg) response of a target muscle as readout. in such studies, a conditioning stimulus modulates the amplitude of the motor-evoked potential (mep) produced by the test stimulus. depending on the inter-stimulus interval, effects can be attributed to different aspects of cortical processing. brief intervals (1-5 ms) will be used to assess short-interval intracortical inhibition (sici) and short-interval intracortical facilitation (sicf), intermediate intervals (7-20 ms) to assess intracortical facilitation (icf) and long intervals (50-200 ms) to assess long-interval intracortical inhibition (lici). some clinical, demographic, and autonomic data (i.e. ekg) will be recorded and used as covariates to investigate any systematic impact on cortical excitability measures collected with the paired-pulse protocols.

Eligibility criteria:
inclusion criteria: * diagnosis of cvs exclusion criteria: * history of cvs (for healthy control population only) * psychosis or altered cognitive status * history of head injury, metal in the skull, stroke, or a history of seizures * implantable devices, such as a pacemaker or nerve stimulator * current use of the following medications or use of substances which are known to lower the seizure threshold: clozapine (clozaril), chlorpromazine (thorazine), amphetamines or methamphetamine, ecstasy, ketamine, angel dust/pcp, cocaine, or 3 or more alcoholic drinks per day * pregnancy
abbott vascular medical device registry

Conditions: Acute Myocardial Infarction; Restenoses, Coronary; Coronary Artery Lesions; Venous Embolism; Arterial Embolism

Summary: the av-mdr is a prospective, non-randomized, open-label, multi-center registry. the purpose of the av-mdr study is to proactively collect and evaluate clinical data on the usage of the devices in scope within their intended use with the aim of confirming safety and performance throughout their expected lifetime, ensuring the continued acceptability of identified risks, detecting emerging risks on the basis of factual evidence, ensuring the continued acceptability of the benefit-risk ratio, and identifying possible systematic misuse or off-label usage such that the intended use can be verified as appropriate.


Eligibility criteria:
inclusion criteria: 1. subject is at least 18 years of age. 2. subject has a planned procedure, or underwent a procedure, that will use/used one or more abbott target devices covered in this registry. 3. subject is willing and able to comply with, or has already completed, the follow-up schedule specified in this protocol. 4. subject must provide written informed consent prior to any clinical investigation-related data collection or be enrolled under an irb/ec approved waiver of consent. exclusion criteria: 1. subject has active symptoms and/or a positive test result of covid-19 or other rapidly spreading novel infectious agent within the prior 2 months of the date of procedure.

Keywords: coronary and peripheral stents abt-cip-10349 vascular plugs pacing catheters measurement and imaging (ffr and oct) peripheral dilatation catheters coronary dilatation catheters coronary and peripheral guidewires vessel closure/compression devices vascular access introducers
a phase 3 clinical trial to evaluate the efficacy and safety of ag2304t and ag2304r

Conditions: Hypercholesterolemia

Summary: a phase 3 clinical trial to evaluate the efficacy and safety of ag2304t and ag2304r in patients with primary hypercholesterolemia


Eligibility criteria:
inclusion criteria: * adults aged 19-80 * patients with primary hypercholesterolemia * those who voluntarily written consent to participate in this clinical trial exclusion criteria: * the subject not meet the specified ldl-c level * other exclusions applied
timing of surgery in nonmetastatic osteosarcoma of the pelvis and sacrum

Conditions: Osteosarcoma of Pelvis

Summary: to study the effect of the timing of surgery on outcome of patients with nonmetastatic osteosarcoma of pelvis and sacrum.

successful therapeutic interventions to prevent disease progression in patients with nonmetastatic osteosarcoma of pelvis and sacrum have included surgery with adjuvant chemotherapy. pre-surgical chemotherapy has been advocated for these patients because of putative improvement in event-free survival (efs). the advantages of pre-surgical chemotherapy include early administration of systemic chemotherapy, shrinkage of primary tumor, and pathologic identification of risk groups. the theoretic disadvantage is that it exposes a large tumor burden to marginally effective chemotherapy, especially in the axial region. the contribution of chemotherapy and surgery timing has not been tested rigorously. to study the effect of the timing of surgery on outcome of patients with nonmetastatic osteosarcoma of pelvis and sacrum, we conducted multicenter randomized trial to determine whether chemotherapy administered before definitive resection of primary tumors improved efs and overall survival compared with traditional resection of the primary tumor followed by adjuvant chemotherapy.

Eligibility criteria:
inclusion criteria: * age \>10 years and \<40 years; * high-grade nonmetastatic osteosarcoma in pelvis or sacrum; * diagnosis confirmed histologically and reviewed centrally; * no evidence of metastatic disease with computed tomography scan of the chest and radionuclide bone scan, or positron emission tomography (pet/ct) within 2 weeks of entry; * no prior therapy; * eastern cooperative oncology group performance status 0-1; * life expectancy \>3 months; * adequate renal, hepatic, and hemopoietic function; exclusion criteria: * previously treated by chemotherapy or unplanned surgery in other hospital; * have had other kinds of malignant tumors at the same time; * uncontrolled complications, such as diabetes mellitus and so on; * intravascular tumor thrombus on enhanced ct or magnetic resonance (mr); * unresectable disease evaluated by surgeons.

Keywords: osteosarcoma pelvis sacrum
percutaneous diskectomy spinejet x open microdiskectomy in treatment of lumbar radiculopathy

Conditions: Radiculopathy; Herniated Disk

Summary: approximately 300,000 patients undergo open surgical procedures to treat symptoms caused by disc herniation. among the various surgical techniques practiced the percutaneous discectomy occupies its space since the first description of the technique by hijikata, 1975. throughout, many techniques have been described. studies indicate that the treatment was successful for pain and disability resulting from herniated disc associated with radiculopathy small. however, some methods remove very small amounts of tissue with little change in volume of the disc. thus, studies on the cadaver with percutaneous diskectomy by spinejet ® showed more macroscopic changes of the disc with a predictable amount of removal and significant disc material. the percutaneous diskectomy by spinejet ® is a new technique of percutaneous diskectomy which creates a suction effect in tissues adjacent to the exit point of the fluid and the opening point of the collector. however, no studies have examined the effect of the percutaneous diskectomy by spinejet ® in humans about the disk size after treatment or measures of disc degeneration by imaging methods or how these characteristics might correlate with clinical outcomes. thus, the study will compare outcomes of patients with contained or extruded disc herniation, with complaints of radiculopathy, concordant with the imaging findings. with treatment by surgical technique or the traditional by spinejet ®, in order to determine whether percutaneous discectomy with spinejet ® will produce results comparable to open microdiskectomy.


Eligibility criteria:
inclusion criteria: * single disc herniation, posterolateral, at any lumbar level, with a size of up to 1 / 3 of the spinal canal sagittal diameter, with radicular pain correlated with findings at mri * failure of nonoperative treatment with at least one anti-inflammatory medication and at least two weeks of physical therapy within a period of 6 months * acceptance of completion of informed consent exclusion criteria: * force \<4 / 5 in a muscle group in the lower limb * herniated disc extrusa large (\> 1 / 3 of the sagittal canal diameter) or sequestered herniation * moderate to grade stenosis of the central canal, lateral recess or foramen * surgery in the previous level involved * herniated disc at another level in the affected side * loss of disc height significantly (\> 60%) compared with the adjacent higher level * infection at the insertion of the device * pregnancy * any illness or medications that contraindicate surgical treatment

Keywords: spine surgery low back pain herniated disk
adherence to polypharmacy in patients with opioid substitution therapy using electronics

Conditions: Substance-Related Disorders

Summary: electronic dispensers for polypharmacy are used in home care to assist patients with their medication management and to improve adherence. opioid dependent patients with substitution therapy often exhibit multiple risk factors for non-adherence. the increase of both the age and associated comorbidities in this population demand for innovative solutions to optimize medication management. the investigators developed a novel medication supply model with an automated electronic medication dispenser to simultaneously assist opioid dependent patients with their medication and objectively monitor their adherence. this study aims to demonstrate the feasibility of the new supply model.


Eligibility criteria:
inclusion criteria: * written informed consent given * reading and writing skills in german * stable housing situation in the canton of basel-city and adjacent communities * accessibility by phone * minimum duration in opioid substitution treatment for 2 months * polypharmacy (\> 3 solid oral medications) * routine monitoring of clinical parameters less than 1 week before inclusion or agreed within 1 week from inclusion * insured with swiss health insurance exclusion criteria: * opioid substitution treatment with diacetylmorphine * \> 2 drugs, which can not be packaged in pouches (eg liquids)

Keywords: pharmaceutical care adherence polypharmacy e-health opioid substitution therapy
oxidative status in children with autoimmune thyroiditis

Conditions: Autoimmune Thyroiditis

Summary: oxidative status in autoimmune thyroiditis was not investigated previously in children and adolescents. we investigated oxidant and antioxidant systems in a cohort of egyptian children and adolescents with ait to explore their relation with biomarkers of autoimmunity and thyroid function.

methods: a case control study included 32 children with autoimmune thyroiditis and 32 healthy subjects with matching age and sex were included as a control group. thorough history, examination, thyroid ultrasound, measurement of thyroid-stimulating hormone (tsh) and free thyroxine (ft4), as well as anti-thyroid peroxidase antibodies (tpoab) and anti-thyroglobulin antibody (tgab) were done in addition to assessment of malondialdehyde (mda) and total antioxidant capacity (tac) levels as an oxidative stress markers. results: overt hypothyroidism was detected in 23/32 while subclinical hypothyroidism was detected in 9/32 of the studied patients. malondialdehyde levels were significantly elevated while total antioxidant capacity levels were significantly decreased in autoimmune thyroiditis patients compared with healthy controls. the difference was more evident in patients with overt hypothyroidism than those with subclinical hypothyroidism. we also observed a significant positive correlation between anti-thyroid peroxidase antibodies levels and age, tsh, malondialdehyde, thyroid volume and a negative correlation with total antioxidant capacity and thyroxine . conclusions: the high serum malondialdehyde and lower total antioxidant capacity levels in patients with autoimmune thyroiditis and the correlation of thyroid antibodies with biomarkers of oxidative stress may reflect the role of autoimmunity in the development of oxidative stress. future studies are needed for evaluation of the antioxidant therapy for autoimmune thyroiditis patients.

Eligibility criteria:
inclusion criteria: * newly diagnosed ait. * age \>6 years \<18 years. * iodine sufficient region. exclusion criteria: * children on antioxidants or antithyroid drugs * cardiac, renal and hepatic disease. * children with other autoimmune and collagen diseases

Keywords: autoimmune thyroiditis oxidative status children
electrical cardiometry in management of acute heart failure

Conditions: Acute Heart Failure (AHF)

Summary: the goal of this clinical trial is to assess if electrical cardiometry (ec) could help in managing acute heart failure (ahf). the main questions it aims to answer are: 1. is there effect of use of cardiometry on rate of use of vasopressors, vasodilators and inotropes? 2. is there effect of use of cardiometry on mortality and hospital length of stay? researchers compared cardiometry to traditional methods like clinical examination, lung ultrasound and inferior vena cava. participants were divided into two groups, one managed by cardiometry and the other by traditional methods, then followed till improvement or death and compared regarding use of medications, length of stay and mortality

the purpose of the research is to assess the role of electrical cardiometry in hemodynamic monitoring in studied cases with acute heart failure to guide treatment. this is a prospective controlled research that involved fifty patients, diagnosed with acute heart failure and admitted to critical care units at alexandria university hospitals, patients were divided into 2 groups: group a: was assessed by traditional methods which include: clinical examination including chest auscultation and systolic blood pressure measurement, lung ultrasound and inferior vena cava assessment and managed according to the results of these parameters. group b: was assessed by electrical cardiometry parameters as cardiac output, thoracic fluid content (tfc) and systemic vascular resistance (svr) and was managed as following: inotropes up and down titration according to cardiac output readings, use of vasopressors or vasodilators according to svr readings, doses of diuretics were modified according to tfc readings.

Eligibility criteria:
inclusion criteria: * acute heart failure exclusion criteria: * pregnant females, atrial fibrillation, severe valvular diseases, skin lesions in thoracic area, large pleural effusion

Keywords: cardiometry, acute heart failure
relationship between heat wave and hyponatremia

Conditions: Hyponatremia

Summary: the objective of this study is to explore the relationship between moderate to severe hyponatremia and heat.

we will explore the relationship between heat wave and moderate and severe hyponatremia in a population of adult patients admitted in the emergency department of a primary and tertiary care teaching urban hospital. we will compare the prevalence of hyponatremia between summer and winter periods. we will describe the types of observed hyponatremia and describe the characteristics of the patients suffering of moderate to severe hyponatremia.

Eligibility criteria:
inclusion criteria: * all adults (\> 16 y) with blood natremia measured exclusion criteria: * patients without measure of natremia in the emergency department