Kornimate/medical-research-clean huggingface dataset:
prevention of stroke and dementia in primary care

Conditions: Stroke; Dementia; Disability

Summary: in western countries, stroke and dementia are the main causes of long-term disability, dependency, and nursing home admission. due to demographic trends a continuous increase of patient numbers can be expected. there is growing evidence that vascular risk factors which are implicated in the etiology of stroke also play important etiologic roles in both vascular dementia and alzheimer disease. the present project is aimed at the reduction of stroke and dementia by means of a systematic detection and subsequent treatment of vascular risk factors by the family doctor based on established guidelines.


Eligibility criteria:
inclusion criteria: * age 55 years or over * member of a particular health insurance plan (aok) * resident of the district of ebersberg exclusion criteria: * none
functional evaluation of two types of totally implanted venous ports

Conditions: Hematologic Disease

Summary: totally implanted venous access ports allow a safe delivery of medication, mainly chemotherapy, but are also used for blood sampling. this last procedure is not always successful, as it appeared from a nurse's survey in different hospitals in flanders, including the university hospitals in leuven, belgium. in 3 to 29 percent of the attempts, blood withdrawal is impaired or not possible, as an intermittent or permanent fact. this is in line with international literature data where difficulty in blood draw was noted in 6 to 26% of port accessions. partial or total occlusion leads to discomfort for the patient, delay in therapy, higher costs and extra nursing time. a new port system with a tangential outlet (vortex port) was designed and according to the manufacturer, this shape will allow to cleanse the entire reservoir of the port more efficiently and avoid the formation of precipitates of medication or blood that could lead to an obstruction of the device. these precipitates are also regarded as a potential risk factor for infection. however, only one previously published small randomised study addressed the value of the vortex port when compared to conventional access devices: stevens et al. were able to show a reduction in obstruction incidence from 26% to 7% with the use of the vortex port. the incidence of blood withdrawal problems in our experience with conventional ports in university hospitals leuven was 8% thus lower than that reported by stevens, but this remains the most frequent problem faced by care providers and patients. with this study, the investigators aim to compare the performance of the tangential outlet ports and that of a "conventional" port in order to assess an eventual functional difference.


Eligibility criteria:
inclusion criteria: * request of a standard size totally implanted venous port * patent superior vena cava * normal clotting tests (pt\>40% and platelet count \>40000/mm3) exclusion criteria: * unable to provide written informed consent

Keywords: oncology, medical implantable catheter vascular access ports persistent withdrawal occlusion vortex® celsite® vacutainer® venous cut-down
adjuvant effects of monochromatic infrared energy in rehabilitation of adolescents with patellofemoral pain syndrome

Conditions: Patellofemoral Pain Syndrome

Summary: this study assessed if integrating monochromatic infrared energy (mire) would affect pain, dynamic postural control, functional status, and health-related quality of life in adolescents with patellofemoral pain syndrome (pfps). forty-six patients with pfps were randomly allocated to the mire group (n = 23, received the received mire in addition to the traditional physical therapy program) or the control group (n = 23, received the traditional physical therapy program only). both groups were assessed for pain, dynamic postural control, functional status, and health-related quality before and after intervention.

forty-six adolescents with pfps were recruited from the university's outpatient orthopedic and physical therapy clinics and two referral hospitals in alkharj, saudi arabia. the study included patients who were 15-18 years old, had anterior-knee or retro-patellar pain that increase with activities like squatting, running, prolonged sitting, or stair climbing, had pfps with insidious onset for more than 6 weeks without any traumatic incidence, and were not participating in a regular exercise program in the past 3 months. patients who had meniscal tears, collateral/cruciate ligament injury, knee arthritis, a history of knee/hip surgery, or previous patellar subluxation/dislocation were excluded. outcome measures pain: pain during rest and/or movement was assessed using the numerical pain rating scale. dynamic postural control: the dynamic postural control was assessed through the modified star excursion balance test (msebt). functional status: the functional status was evaluated using the arabic version of the anterior knee pain questionnaire (kujala questionnaire). quality of life: the quality of life was assessed through the self-report pediatric quality of life inventory. interventions the mire group underwent mire application on the affected knee for 40 minutes, 3 times a week for 3 consecutive months. the mire was delivered using an anodyne therapy professional infrared therapy system (parameter: a wavelength of 890 nm and radiant power at a rate of 6.24 w). participants in the mire group further received the traditional physical therapy program (60 minutes/session) that consisted of stretching and strengthening exercises for the muscles surrounding the hip and knee, balance exercises, as well as other electrotherapeutic modalities (ultrasound and hot application). the control group received the traditional physical therapy program only.

Eligibility criteria:
inclusion criteria: * age between15 and18 years. * anterior-knee or retro-patellar pain that increases with activities like squatting, running, prolonged sitting, or stair climbing. * pfps with insidious onset for more than 6 weeks without any traumatic incidence. * not participating in a regular exercise program within the last three months. exclusion criteria: * meniscal tears * collateral/cruciate ligament injury * knee arthritis * history of hip/knee surgery * previous patellar subluxation/dislocation
clinical benefits of a multimodal physiotherapy programme in fighter pilots with flight-related neck pain

Conditions: Neck Pain

Summary: the aim of this study was to analyse the immediate effects of a 4-week multimodal physiotherapy program which combines cervical supervised exercises with laser-guided feedback (elgf) and interferential current electro massage (ice) in fighter pilots with flight-related neck pain.

flight-related neck pain constitutes a clinical entity related to the performance and flight safety of fighter pilots. the aim of this study was to analyse the effectiveness of a multimodal physiotherapy program which combines supervised exercise with laser-guided feedback (elgf) and interferential current electro-massage (ice) in fighter pilots with flight-related neck pain. 31 pilots were randomly allocated into two groups (experimental group n=14; control group n = 17). the intervention consisted of 8 sessions (twice a week) for 4 weeks. as primary outcome measures the following variables were measured: perceived pain intensity (numeric pain rating scale) and neck disability (neck disability index). the secondary outcome measures were: cervical range of movement (crom), joint position sense error (jpse) and pressure pain threshold (ppt).

Eligibility criteria:
inclusion criteria: * flight pilots (male and female) who, at the time of the assessment, were an instructor or student attached to the 23th wing of talavera air base, spanish air force (saf), badajoz. * flight pilots diagnosed with flight-related neck pain according to the international classification proposed by an expert panel of the north atlantic treaty organisation (nato). * a minimum perceived pain of 3/10 on the visual analogue scale (vas) in the early-morning assessment. * scores of ≥5 points on the neck disability index (ndi), and a cervical-repositioning error of ≥4.5°. exclusion criteria: * cervical pain with radiation to the upper limbs and/or radiculopathy. * cervical spine surgery with or without the presence of a metal implant. * having received physiotherapy or any other routine medical care six weeks prior to data collection. * being involved in ongoing medical-legal conflicts.

Keywords: fighter pilots flight-related neck pain disability electric massage therapeutic exercise
the comparison of single catheter and double catheter adrenal vein sampling methods based on the upper limb approach

Conditions: Primary Aldosteronism

Summary: primary aldosteronism (pa) is a clinical syndrome characterized by the autonomous overproduction of aldosterone by the adrenal cortex's zona glomerulosa, leading to hypertension, elevated aldosterone levels, and suppressed renin activity as the primary manifestations. studies have shown that the prevalence of pa in an unselected hypertensive population ranges from 5% to 11% , while the prevalence in patients with resistant hypertension is approximately 20% . pa is one of the most common causes of secondary hypertension , and its prevalence increases with rising blood pressure levels. due to the adverse effects of pa on the heart, arterial walls, and kidneys, it contributes to the occurrence of cardiovascular events, with atrial fibrillation being the most common . in summary, pa is characterized by rapid onset, significant symptoms, obscurity, and severe complications, making early diagnosis and targeted treatment essential for prevention. this study aims to explore a quasi-selected prospective randomized controlled method to compare the clinical efficacy differences between single-catheter and dual-catheter adrenal sampling via the right upper limb approach. the study seeks to clarify the effectiveness and safety of single-catheter sampling from the upper limb, providing a more efficient and cost-effective solution for the subtype diagnosis of patients with primary aldosteronism (pa).


Eligibility criteria:
inclusion criteria: * patients aged 18-70 years with hypertension. * initial screening shows a standing aldosterone/renin ratio (arr) \> 3.7, a baseline aldosterone level \> 10 ng/dl, aldosterone level \> 6 ng/dl after a saline load test, or aldosterone decrease of less than 30% after a captopril suppression test, consistent with a diagnosis of primary aldosteronism. * voluntary participation in the trial, with signed informed consent. exclusion criteria: * patients with an allergy to iodinated contrast agents. * patients who are pregnant, breastfeeding, or planning to become pregnant. * patients with severe comorbidities, such as renal failure, liver cirrhosis, metastatic tumors, or those who have had an acute stroke or acute myocardial infarction, as well as patients with a history of surgery within the past month. * patients suspected of having adrenal cortical carcinoma.
a novel low-cost tool for a more efficient and reliable weight-for-height/length assessment

Conditions: Severe Acute Malnutrition; Wasting

Summary: weight-for-height/length z-score is one of the indicators used to diagnose acute malnutrition. in the existing method, the assessment involves three steps and takes significant time with a wider room for errors. a new tool is developed to address these drawbacks. a preliminary testing done show encouraging results, but a more robust study is needed. this research will b done with the objective of comparing diagnostic efficiency and reliability of the 'new' method against the 'existing' one using a diagnostic randomized clinical trial method.

acute malnutrition is a major underlying and direct cause of child death. weight-for-height/length z score (whz) is one of the indicators used to assess nutritional status of children. in the existing method, the assessment involves three steps; measuring height, measuring weight and deciding whz using a reference graphs or tables. the assessment takes significant time and has wider room for errors. due to these drawbacks, it is not used at community level where regular active finding takes place. a new tool is developed to address these drawbacks. it reduces the steps to two aiming at reducing errors and saving time and energy. this study will compare efficiency and reliability of whz assessments done with the new tool against the existing method using a diagnostic randomized clinical trial. trained health workers will do whz assessments in under five children mobilized for nutrition screening program. the 'average time' needed and proportions of 'classification errors' will be compared between the new and the existing methods. assessments done by two anthropometry experts will be used as gold standard. the study will determine the gains of the new tool and can potentially change the global practice and help early detection of huge number of wasted children that are being missed.

Eligibility criteria:
inclusion criteria: * all children under five years of age living in the study area. exclusion criteria: * children for whom weigh-for-height assessments can not be done due to physical deformities and disabilities.

Keywords: weigh-for-height/length assessment
effectiveness of an online bulletin board for depression: a longitudinal randomized controlled trial

Conditions: Depression

Summary: this study is a randomised controlled trial that aims to examine the efficacy of an established online bulletin board for depression. it has been estimated that millions of people worldwide use peer-to-peer bulletin boards, forums or internet support groups (isgs) for health conditions. however, little is known about the effectiveness of these groups in terms of symptom reduction or improvement in quality of life. the current project investigates the effectiveness of an established online bulletin board for depression available to the public. to our knowledge, this is the first randomised controlled trial of the effectiveness of a pre-existing, well-established online bulletin board for depression in the community. the aims of the project are to determine whether the bulletin board improves mental health, quality of life, and related outcomes among members of the community with high levels of self-reported psychological distress and previous history or current experience of depression.


Eligibility criteria:
inclusion criteria: 1. over 18 years of age 2. internet access with email 3. self-report of current or previous experience of depression exclusion criteria: 1. current participation in an online support group for depression 2. diagnosis of bipolar disorder, schizophrenia, or psychosis

Keywords: depression mental health wellbeing online bulletin board online support group
intracranial pressure waves via lumbar puncture

Conditions: Idiopathic Normal Pressure Hydrocephalus

Summary: patients are subjected to simultaneous intracranial and lumbar puncture pressure measurements. this study focus on intracranial pulse amplitude. hypothesis: intracranial pressure amplitude is reflected by lumbar puncture pressure amplitude.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of idiopathic normal pressure hydrocephalus exclusion criteria: * known cause of hydrocephalus
registry of multicenter brain-heart comorbidity in china

Conditions: Ischemic Heart Disease; Cardiac Arrest; Atrial Fibrillation; Heart Failure; Aortic Diseases; Subarachnoid Hemorrhage; Intracerebral Hemorrhage; Cerebral Infarction; Occlusion and Stenosis of Precerebral Arteries; Occlusion and Stenosis of Cerebellar Arteries; Cerebral Aneurysm; Moyamoya Disease; Arteriovenous Malformation of Cerebral Vessels

Summary: this study is a multi-center, prospective, registry study. this research was supported by the national key research and development program. to establish a domestic multi-center, large-scale "brain-heart comorbidity" dynamic database platform including clinical, sample database, image and other multi-dimensional information requirements, through the construction of a multi-center intelligent scientific research integration platform based on artificial intelligence. any of newly diagnosed cardiovascular related diseases were identified via icd-10-cm codes: i21, i22, i24 (ischaemic heart diseases) \[i.e., acs\], i46 (cardiac arrest), i48 (atrial fibrillation/flutter), i50 (heart failure), i71 (aortic disease), i60 (subarachnoid hemorrhage), i61 (intracerebral hemorrhage), i63 (cerebral infarction), i65 (occlusion and stenosis of precerebral arteries), i66 (occlusion and stenosis of cerebral arteries), i67.1 (cerebral aneurysm), i67.5 (moyamoya diseases), q28.2 (arteriovenous malformation of cerebral vessels). the data is stored on the brain-heart comorbidity warehouse via a physical server at the institution's data centre or a virtual hosted appliance. the brain-heart comorbidity platform comprises of a series of these appliances connected into a multicenter network. this network can broadcast queries to each appliance. results are subsequently collected and aggregated. once the data is sent to the network, it is mapped to a standard and controlled set of clinical terminologies and undergoes a data quality assessment including 'data cleaning' that rejects records which do not meet the brain-heart comorbidity quality standards. the brain-heart comorbidity warehouse performs internal and extensive data quality assessment with every refresh based on conformance, completeness, and plausibility (http://10.100.101.65:30080/login).


Eligibility criteria:
inclusion criteria: * age \> 18 years old * any of newly diagnosed cardiovascular-related diseases were identified via icd-10-cm codes: i21, i22, i24 (ischaemic heart diseases) \[i.e., acs\], i46 (cardiac arrest), i48 (atrial fibrillation/flutter), i50 (heart failure), i71 (aortic disease), i60 (subarachnoid hemorrhage), i61 (intracerebral hemorrhage), i63 (cerebral infarction), i65 (occlusion and stenosis of precerebral arteries), i66 (occlusion and stenosis of cerebral arteries), i67.1 (cerebral aneurysm), i67.5 (moyamoya diseases), q28.2 (arteriovenous malformation of cerebral vessels). exclusion criteria: ·refuse to participate in the registry
a study to find the maximum tolerated dose of the experimental combination of the drugs inc424 and bkm120 in patients with primary or secondary myelofibrosis

Conditions: Myelofibrosis

Summary: the purpose of this phase ib clinical trial is to evaluate the safety of the combination of inc424 and bkm120 in the myelofibrosis population and to establish the maximum tolerated dose and or the recommended phase ii dose of the combination guided by the bayesian dose escalation model. inc424 has shown efficacy in myelofibrosis (mf) and is approved in the us and eu for the treatment of mf. bkm120 is a pi3k inhibitor. preclinical and early clinical experience support inhibition of the pi3k/mtor pathway in mf as aberrant activation of the pathway has been observed in mf models and may contribute to the pathogenesis of the disease.


Eligibility criteria:
inclusion criteria: * diagnosed with pmf, ppv-mf or pet-mf irrespective of jak2 mutation status * myelofibrosis patients requiring therapy must be classified as intermediate risk level 1 )1 or more prognostic factors defined by iwg) with at least one criteria other than age * must have palpable spleen of at least 5 cm from the costal margin to the point of greatest splenic profusion at screening * must have active symptoms of mf (one symptom score of at least 5 or two symptom scores of at least 3 at screening) (per mfssf 0-10) * plt counts \> or = 75x 10\^9/l at screening or cycle 1 day 1 (not with aid of transfusions exclusion criteria: * pregnant or nursing women * wocbp not using highly effective methods of contraception * sexually active males who refuse condom use * previous treatment with one of the following: pi3 k inhibitors and akt inhibitors; jak inhibitors that resulted in clinically significant toxicities per the investigator; * patients who have had splenic irradiation within 12 months prior to screening * patients with specific mood disorders * any history of bleeding diathesis * patients receiving the following treatments / medications: eiaed within 2 wks. prior to study treatment; medication known to prolong qt interval or induce torsades de pointes; treatment with potent systemic systemic inhibitor or systemic inducer of cyp3a4; any use of drug that interferes with coagulation or inhibits plt function -current and willing candidates for a stem cell transplantation

Keywords: myelofibrosis, pmf, ppv-mf, pet-mf, primary myelofibrosis, post-polycythemia vera myelofibrosis, post-essential thrombocythemia myelofibrosis
a physical activity intervention to promote cognitive health, cardiovascular health and sleep in older latinos

Conditions: Mild Cognitive Impairment

Summary: this study is a randomized, single-blind, controlled trial that will test a multilevel intervention, tiempo juntos para la salud, (time together for health) designed to promote moderate-intensity physical activity; theoretically grounded mediators; and secondary outcomes of cardiovascular health, sleep and cognitive function. participants will have 4 visits over a year long period. data collection will occur at baseline, 3 months, 6 months, and 12 months among 216 spanish language-dominant latinos aged 55 and older with mild cognitive impairment (mci) \[montreal cognitive assessment (moca) score 23 to 26 for latino populations\].


Eligibility criteria:
inclusion criteria: * can provide informed consent * 55+ years * self-identify as hispanic/latino * spanish as primary language * willing to attend intervention / education sessions * access to phone/cell * less than 150 min of activity / week (sedentary) * montreal cognitive assessment (moca) score (score ≥ 23 to 26 for latino populations) exclusion criteria: * cannot provide informed consent * mobility disability * musculoskeletal problem / co-morbidity (prevents moderate pa)

Keywords: older latinos cardiovascular health sleep quality cognitive function community health worker walking physical activity