Kornimate/medical-research-clean huggingface dataset:
puncture breast abscess

Conditions: Breast Abscess

Summary: several breast diseases can complicate breastfeeding : 4% of women develop a mastitis and 1% develop an abscess. the study deals with cases of breast abscess that have been treated according to a defined protocol (parisian perinatal health network), by a multidisciplinary team (center of medical imaging duroc) trained in breastfeeding and ultrasound-guided punctures. the aim of the study is to define the risk factors for the onset of a breast abscess, to evaluate the indications and methods of management of abscess by ultrasound puncture, and to provide arguments motivating the continuation of breastfeeding.


Eligibility criteria:
inclusion criteria: * nursing mothers * patients referred for breast abscesses during lactation * having an abscess confirmed ultrasoundly and indicating a puncture * women punctured of an abscess of the breast abscess in the center of medical imaging duroc * not opposing the use of them given and to answer the questionnaire on the immediate and medium-term future by telephone * women aged \> 18 years old * women understanding french * affiliated to social security exclusion criteria: no

Keywords: breast feeding breast abscess ultrasound-guide puncture health
performance of fish for the diagnosis of malignant biliary strictures in thai patients

Conditions: Bile Duct Stricture; Malignancy

Summary: fluorescence in situ hybridization (fish) has improved the diagnostic performance of cytology for evaluation of malignant biliary strictures in the us and europe. the utility of fish for diagnosis of biliary strictures in asia is currently unknown. the investigators conducted a prospective study in 2 university hospitals to determine diagnostic performance of fish for the diagnosis of malignant biliary strictures in thai patients.

fluorescence in situ hybridization (fish) has improved the diagnostic performance of cytology for evaluation of malignant biliary strictures in the us and europe. the utility of fish for diagnosis of biliary strictures in asia is currently unknown. the investigators aimed to compare the sensitivity of fish and conventional cytology for the diagnosis of malignant biliary strictures in thai patients. a prospective study was performed in 2 university hospitals between 2010 and 2013. patients being evaluated for malignant-appearing biliary strictures were included. bile duct brushings were collected and assessed by cytology and fish. sensitivities with 95% confidence intervals of cytology and fish were main outcome measurements.

Eligibility criteria:
inclusion criteria: * age \> 18 years * clinical suspicion of malignant biliary tract strictures
prediction of clinical outcome in lumbar espb

Conditions: Pain, Chronic

Summary: the primary endpoint of this study was to identify that perfusion index (pi) has any predictive value for the treatment outcome of cervical radiculopathy

the erector spinae plane block (espb) is a less invasive, safer, and technically easy alternative procedure to conventional neuraxial anesthetic techniques. in contrast to common neuraxial techniques such as paravertebral and epidural injections, the espb targets an interfascial plane which is far from the spinal cord, root, and pleura. first applied to thoracic neuropathic pain, currently espb is being applied to postoperative pain control and includes variable clinical situations. in the abdomen and thoracic wall, thoracic espb can be applied for pain control after cardiac surgery, video-assisted thoracic surgery, laparoscopic cholecystectomy, and thoracotomy. recently, favorable postoperative pain control after lumbar spinal or lower limb surgeries has been reported with lumbar espb. in addition, espb has also been used for chronic pain conditions in the upper and lower extremities. the perfusion index (pi) is a numerical value for the ratio between pulsatile and non-pulsatile blood flow measured by a special pulse oximeter. although the special probe for pi measurement is relatively more expensive compared with ordinary pulse oximetery probes, its benefit as a marker of peripheral perfusion and as an idex for sympathetic stimulation have increased its use progressively. pi has been used widely for the prediction of success of brachial plexus block or axillary block. changes of pi ratio value showed an excellent predictive value for the success of block. there have been no studies demonstrating predictive value of pi in lumbar espb espb for the relief of low back pain or leg pain due to lumbar disc herniation or stenosis.

Eligibility criteria:
inclusion criteria: * lumbar foraminal stenosis * lumbar central stenosis * lumbar disc herniation * lumbar spondylolisthesis exclusion criteria: * infection * pregnancy * allergy to local anesthetic agnets * previous lumbar spine surgery
evaluation of postoperative pain control in ear surgery

Conditions: Post Operative Pain; Analgesia

Summary: middle ear surgery is the most popular procedure in ear, nose and throat surgery. increased sympathetic stimulation after surgery can activate the sympathetic system, causing hypertension and increased heart rate. as a result of these clinical conditions, hemorrhage can occur, which can impair the quality of the surgical field, which is undesirable in middle ear surgery.clinical studies should be conducted with auricularis magnus nerve block applied in the perioperative period in middle ear surgery and postoperative pain scores.

middle ear surgery is the most popular procedure in ear, nose and throat surgery. increased sympathetic stimulation after surgery can activate the sympathetic system, causing hypertension and increased heart rate. as a result of these clinical conditions, hemorrhage can occur, which can impair the quality of the surgical field, which is undesirable in middle ear surgery.ultrasound-guided auricularis magnus nerve block can be used as a potential solution to these problems. ultrasound-guided peripheral nerve block can be visualized. it is appropriate and applicable to block a single distal nerve with a small dose of local anesthetic under ultrasound guidance. ultrasound-guided blocking of the blocked area has reduced side effects with increased accuracy and accurate analgesic effect. in middle ear microsurgery, the nerve innervation of the postauricular incision area may not primarily originate from the auricularis magnus. therefore, clinical studies should be conducted with auricularis magnus nerve block applied in the perioperative period in middle ear surgery and postoperative pain scores.

Eligibility criteria:
inclusion criteria: * patients undergoing cwd and mastodectom * patients undergoing elective surgery * asa (american society of anesthesiologists) physical status classification i-ii * patients over 18 years of age exclusion criteria: * anticoagulant use * allergy to the drugs to be used * asa (american society of anesthesiologists) physical status classification iv-v * presence of infection in the area where the block will be applied * patient's refusal to accept the block application or inability to cooperate with the patient

Keywords: regional anesthesia ear surgery auricularis magnus nerve block
study for her2-overexpressed mbc patients treated by cipterbin® plus vinorelbine

Conditions: Progress-free Survival; Overall Response Rate; Adverse Events

Summary: breast cancer is the most common malignant disease and the most frequent causes of cancer mortality in females worldwide. the situation is same as the world in china. trastuzumab has been proved valuable treatment for her2-positive breast cancer patients. cipterbin® is developing by shanghai cp guojian pharmaceutical co.ltd.now we carried on the phase iii trial in order to prove cipterbin® 's efficacy and safety.


Eligibility criteria:
inclusion criteria: * signed icf * pathologic diagnosis breast cancer * her2+ status defined as ihc3+ staining or in situ hybridization positive at least 1 measurable lesion as per recist criteria age from 18y to 70y kps\>=70 exclusion criteria: * more than three prior chemotherapy lines for advanced disease lvef\<50% * prior exposure vinorebine for breast cancer * prior exposure trastuzumab for breast cancer * uncontrolled brain metastasis * breastfeeding or pregnant
impact of lipoic acid use on stroke outcome after reperfusion therapy in patients with diabetes (important)

Conditions: Stroke, Ischemic

Summary: this study aims to investigate the effectiveness and safety of alpha-lipoic acid in patients with diabetes and ischemic stroke treated with reperfusion therapy.

despite significant advances in the prevention and treatment of stroke, it is still one of the leading causes of death and debilitating disease. unfortunately, several neuroprotective strategies have failed in clinical trials. at present, it is reported that there are no pharmacological agents with putative neuroprotective actions that have demonstrated efficacy in improving outcomes after acute ischemic stroke (ais) in humans. previous stroke studies have confirmed that oxidative stress plays a vital role in stroke and in reperfusion following stroke. therefore, the use of antioxidants could be a promising strategy for treating ischemia-reperfusion injury. alpha-lipoic acid (ala) is a potent antioxidant commonly used for the treatment of diabetic polyneuropathy (dpnp). the investigators previously demonstrated the neuroprotective and neurorestorative effects of ala, mediated at least partially via insulin receptor activation, after cerebral ischemia in rats. moreover, previous observational study of the investigators showed that patients with diabetes treated with ala have better functional outcomes following ais after reperfusion therapy than patients not using ala. therefore, the investigators investigate whether patients with diabetes treated with ala have better functional outcomes after ais and reperfusion therapy than patients not treated with ala in this prospective randomized trial.

Eligibility criteria:
inclusion criteria: * patients with acute ischemic stroke within 6 hours of symptom onset * patients with diabetes * patients who underwent reperfusion therapy (intravenous t-pa or endovascular thrombectomy) exclusion criteria: * pre-existing disability (modified rankin scale \>= 1) * patients with severe renal disease (gfr \<30 ml / min) * patients whose survival period is expected to be less than 12 months due to serious diseases such as terminal cancer or liver failure

Keywords: reperfusion lipoic acid stroke
how secreted-embryo-derived trypsin initiates, maintains and terminates ca2+ signals in uterine epithelial cells

Conditions: Infertility; Infertility, Female; Aneuploidy

Summary: to develop a deeper understanding of endometrial-embryo crosstalk through basic research, uncover therapeutic targets and to improve reproductive outcome.

pregnancy is a complex and highly coordinated physiological process that involves implantation of a hatched blastocyst into a decidualizing endometrium. the main purpose of implantation is to ensure that the blastocyst firmly anchors into the decidual stroma, which allows further development by enabling placentation. although a multitude of cellular events and molecular pathways involved in embryo-uterine crosstalk have been identified in mouse models, a comprehensive understanding of human embryo-uterine interaction is still missing. our work indicates that endometrial epithelial ca2+ signalling in response to serine proteases released by human embryos plays an important role in maternal recognition and selection of the conceptus at implantation. previous studies have demonstrated that trophoblast spheroids can elevate \[ca2+\]i in human uterine epithelial cell line (ishikawa) by activating ca2+ entry via mechano-sensitive ca2+ permeable channels leading to the induction of epithelial adhesiveness. however, the mechanism(s) mediating the protease-induced \[ca2+\]i transients in human uterine epithelium have not been studied to date. investigators hypothesise that na+ entry into the intravillous space via trypsin-activated enac will depolarise the cellular membrane and increase \[na+\]v sufficiently high to reverse the sodium/calcium exchanger providing means for ca2+ entry into the intravillous space. ca2+ diffusion from the microvilli into the bulk cytoplasm will increase \[ca2+\]i and, in parallel with soce, act as a source for re-filling of the er. increased \[ca2+\]i will also activate the bk channels leading to repolarisation and termination of ca2+ entry via the ncx. by using spent medium from embryos, which will undergo pre-implantation genetic testing, it will become possible to determine, whether the above mentioned mechanisms are influenced by the ploidy status of the embryo.

Eligibility criteria:
inclusion criteria: * couples with primary / secondary infertility who are planned to undergo icsi treatment with pgt-a * age of each partner above 18 years exclusion criteria: * couples with consanguinity (couple who is 1st or 2nd degree cousins) * couples in whom the female partner has a history of: * chemotherapy or radiation which impacts the ovarian reserve * surgery at the ovaries / adnex region * endometriosis * couples in whom the male partner has a history of: * chemotherapy / radiation which impacts the semen result * surgery at the testicles * vasectomy * surgery for reversal of vasectomy * semen obtained by fine needle aspiration (fna) or testicular sperm extraction (tese)

Keywords: ivf rna ca2+ embryo media
evaluating the association between changes in the gut microbiome, fatigue, and chemotherapy-induced nausea in early stage breast cancer

Conditions: Chemotherapy-Related Nausea and/or Vomiting; Early Stage Breast Carcinoma; Anatomic Stage I Breast Cancer AJCC v8; Anatomic Stage II Breast Cancer AJCC v8

Summary: this pilot study seeks to understand how changes in the bacteria composition (microbiome) of the gut may be associated with the occurrence of fatigue and chemotherapy-induced nausea (cin) in women undergoing chemotherapy for early stage breast cancer. patients undergoing chemotherapy may experience fatigue or nausea as a result of their treatment. known risk factors for fatigue and cin do not explain the differences in fatigue and cin occurrence between patients, but changes in the functions of the gut microbiome may be related to the occurrence of fatigue and cin. this study collects stool samples from breast cancer patients before and after chemotherapy to evaluate how changes in the microbiome may be associated with fatigue and cin.

primary objectives: i. evaluate the feasibility of patient recruitment and retention, as well as specimen collection. ii. estimate the effect size for changes in gut microbiome composition profiles and metabolites in stool as well as blood from time of first stool sample collection prior to chemotherapy (t1) to time of second stool sample collection after chemotherapy (t2) that are associated with the occurrence of fatigue and cin. iii. evaluate associations between patient reported demographic and clinical characteristics, comorbidities at t1, and changes in gastrointestinal and neuropsychological symptoms, food intake as well as exercise from t1 to t2 with the occurrence of fatigue and cin. outline: this is an observational study. patients undergo collection of stool and blood samples and complete questionnaires on study.

Eligibility criteria:
inclusion criteria: * subjects with a diagnosis of early stage breast cancer planning to receive moderate to highly emetogenic chemotherapy will be recruited at mayo clinic health systems including mankato and albert lea; mayo clinic arizona; mayo clinic rochester (minnesota); and mayo clinic florida * at least 20 years of age * last chemotherapy more than 3 years ago * scheduled to receive moderate to highly emetogenic chemotherapy with or without targeted therapies including immunotherapies exclusion criteria: * metastatic disease * concurrent radiation therapy * concurrent antibiotic treatment
prophylaxis of graft-versus-host disease with anti-cd25 antibody in patients underwent hsct

Conditions: GVHD

Summary: the risk of graft-versus-host disease(gvhd) is significantly associated with the mortality rate of patients undergoing allogeneic hematopoietic stem cell transplantation. the occurrence of gvhd increases the hospitalization rate and economic burden of patients. in order to explore better methods for controlling gvhd, we designed a clinical trial using cd25 monoclonal antibody for gvhd prevention. our previous studies have shown that reduced-dose anti-thymocyte globulin(atg) in the conditioning regimen can achieve the same effect as full-dose atg. here, we try to explore the preventive effect of cd25 antibody on acute and chronic ghvd under low-dose atg pretreatment condition.


Eligibility criteria:
inclusion criteria: * patients with a clear diagnosis of hematologic disease, weighing ≥30kg, aged 18-60, of any gender and race; * willing to undergo haploidentical hematopoietic stem cell transplantation; * voluntarily participate in this study; * each subject must sign an informed consent form (icf) indicating their understanding of the purpose and procedures of the study, and their willingness to participate. considering the patient 's condition, if the patient' s signature is unfavorable for disease treatment, the informed consent form should be signed by the legal guardian or the patient 's immediate family member. exclusion criteria: * those with severe organ dysfunction or diseases, such as heart, liver, kidney, and pancreatic diseases; * patients who cannot tolerate cd25 monoclonal antibody treatment; * subjects and/or authorized family members who refuse allo-hsct treatment; * any life-threatening diseases, physical conditions, or organ system dysfunctions that the researcher believes may jeopardize the safety of the subject and pose unnecessary risks to the study; drug dependence; uncontrolled mental illness in subjects; cognitive dysfunction; * those who have participated in other similar clinical studies within the past 3 months; * those deemed unsuitable for inclusion by the researcher (such as patients expected to be unable to adhere to treatment due to financial issues, etc.).
sodium hypochlorite pulpotomies in primary molars: comparison with conventional 20% formocresol pulpotomies

Conditions: Dental Pulp Disease

Summary: formocresol (fc) is the most universally taught and most widely used pulpotomy medicament in the primary teeth. however, concerns have been raised over the use of fc because of its toxicity and potential carcinogenicity. a substitution for fc has been investigated but evidence is lacking to conclude which is the most appropriate technique for pulpotomies in primary teeth. sodium hypochlorite (naocl) has been used in root canal irrigant for more than 80 years, and it is at present the most popular irrigant in root canal treatment. studies have showed that naocl is biological compatible and is a very good antimicrobial solution without being a pulpal irritant. recent studies using sodium hypochlorite as pulpotomy medicament in primary molars showed promising results. in this project, the investigators propose a randomized clinical trial, which will be performed in pediatric dentistry department of the national taiwan university hospital, to compare the treatment outcomes between naocl and fc in human primary molars needing pulpotomy treatment. the aim of this sudy is to determining weather naocl is a suitable replacement for fc in the pulpotomy of human primary molar teeth. to assess this aim, 200 healthy children from 2.5 to 9 year-old, who have at least one primary first or second molars diagnosed to receive pulpotomy treatment will be recruited in this project. the involved teeth will be randomly assigned to the control group (dilute 20% formocresol (dfc)) or experimental group (2.5% naocl). at 3, 6, 9, 12, 15, 18, 21 and 24 months post-treatment, the randomly assigned teeth will be clinically and radiographically evaluated by blinded independent evaluators to the treatment group. the differences will be statistically analyzed using chi-square test, fisher exact test, and t-test, using a statistical significance at p\<0.05.

as brief summary.

Eligibility criteria:
inclusion criteria: * healthy, american society of anesthesiologists (asa) physical status classification system class i children * age between 2.5 and 9 years old * with one or more primary molars need pulpotomy treatment exclusion criteria: * children younger than 2.5 or older than 9 years of age
prevalence of potential cytochrome p450 pharmacokinetic incident drug-drug interactions(ddi) among osteoarthritis patients

Conditions: Osteoarthritis

Summary: using a retrospective database analysis, oa patients taking at least one cyp450-metabolized opioid (codeine, fentanyl, hydrocodone, methadone, oxycodone, or tramadol) and at least one other prescription drug metabolized via the cyp450 system were evaluated for an incident drug-drug exposure (dde), which places them at risk for experiencing a pharmacokinetic drug-drug interaction (ddi).


Eligibility criteria:
inclusion criteria: * osteoarthritis exclusion criteria: * pregnancy

Keywords: retrospective database analysis in osteoarthritis patients
mac vs tiva ambulatory breast augmentation

Conditions: Breast Diseases

Summary: hypothesis: the combination of la with remifentanil and ketofol \[monitored anesthesia care (mac)\] for ambulatory breast augmentation may result in results in better qor on day of surgery as compared with total i.v. anesthesia (tiva) . the purpose of this study was to compare the qor after mac using remifentanil and ketofol with tiva during ambulatory breast augmentation .

breast augmentation surgery is commonly performed on an ambulatory basis under under general anesthesia (ga) with propofol and remifentanil or local anesthesia (la). although surgeons perform this operation comfortably under ga, patients have anxiety and fear of complications due to ga. in addition, they expect a good postoperative quality of recovery (qor) including ability to resume common activities (work and daily activities) without suffering from moderate to severe pain. the la is advantageous over ga in that airway instrumentation is not necessary, favorable recovery profile, decrease postoperative pain and vomiting, increase patient satisfaction and decrease the cost . however, patient anxiety or pain often leading to conversion of la to ga, which suggests the concomitant use of i.v. sedatives and analgesics as a supplement to la. the combination of remifentanil and ketofol (propofol, ketamine) for sedation during regional anesthesia and la has been shown to be a safe, effective technique, capable of maintains adequate analgesia with conscious sedation, haemodynamic stability, and achieves lower incidence of postoperative nausea and vomiting with shorter recovery times.

Eligibility criteria:
inclusion criteria: * asa i, ii exclusion criteria: * asa iii