Kornimate/medical-research-clean huggingface dataset:
comparison of hemoccult, magstream and oc-sensor faecal occult blood tests in colorectal cancer screening

Conditions: Colorectal Cancer

Summary: colorectal cancer screening by faecal occult blood test (fobt) is a high public health priority. the interest of guaiac tests (g-fobt) is limited by their poor sensitivity, while the superiority of i-fobt in comparison with g-fobt is now established. nevertheless automated quantitative i-fobts have not been compared, and the optimal number of samples and threshold is not yet fixed. the aim of this study is to compare the performances of the 2 more well-known i-fobts with automated analyzers (magstream by fujirebio, and oc sensor by eiken) for different positivity thresholds and numbers of samples in general average risk population. patients will performed a two samples magstream, a two samples oc sensor and hemoccult ii. in case of a positive test, a colonoscopy will be performed. sensitivity and specificity for detection of cancer and advanced neoplasias will be compared between tests using ratio of sensitivities (rsn) and ratio of false positives (rfp) according to number of samples and positivity threshold.


Eligibility criteria:
inclusion criteria: * 50 to 74 years * informed consent signed exclusion criteria: * recent digestive symptoms * complete colonoscopy less than 5 years ago * personal history of colorectal cancer or colorectal adenoma or colonic disease requiring regular colonoscopy surveillance * familial history of colorectal cancer in a first degree next of kin before 65 years, or two cases in first degree next of kin. * severe extra-intestinal disease * screening ill-timed (ex. depression)

Keywords: colorectal cancer screening average-risk population faecal occult blood tests
gold 0 - dlco 1: a look beyond the obstruction. is spirometry enough for copd (chronic obstructive pulmonary disease) screening?

Conditions: COPD, Chronic Obstructive Pulmonary Disease

Summary: this is a multicenter observational prospective study in smokers or ex-smokers with cumulative exposure ≥ 10 a / p (years / pack) with respiratory symptoms and presenting a normal spirometry. the patients who sign the corresponding informed consent, will undergo a dlco and will be divided into two groups according to the result: * group i. patients with dlco \<80%. * group ii patients with dlco≥80%. both groups will be followed for 5 years.


Eligibility criteria:
inclusion criteria: * age ≥18 years. the participant or his / her legal representative is willing and able to give informed consent to participate in the study. * female or male patients with age equal to or greater than 18 years. * smokers or ex-smokers with cumulative exposure ≥ 10 a / p * respiratory symptoms * normal spirometry. exclusion criteria: * age under 18 years. * participation in another clinical study. * patients with a life expectancy of less than 2 years due to neoplasms or other serious systemic diseases. * refusal to sing informed consent.
effect of nano-curcumin supplementation in acute pancreatitis

Conditions: Acute Pancreatitis

Summary: this study aims to investigate the effect of nano-curcumin supplementation on hospital length of stay, clinical outcomes, and inflammation level in mild and moderate acute pancreatitis. 42 eligible patients with mild and moderate acute pancreatitis will randomly assign to consume two soft gels each containing 40 mg of nano-curcumin or placebo (control group) every morning and evening for two weeks. both groups will also receive the standard medical treatment of acute pancreatitis according to relevant guidelines. patient's blood samples and clinical outcomes will assess on days 0, 1, 2, 3, 4, and 14 of admission. the two groups will also be compared in terms of adverse events and hospital length of stay. moreover, the patient's hospital readmission due to pancreatitis will be recorded within 90 days of hospitalization.

the dietary intake of patients will be examined by two non-consecutive 24-hour food recalls at baseline and end of the study. the patient's weight (kg) and body mass index (bmi) will also be measured.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute pancreatitis by at least two of the three following criteria: 1) a history of acute abdominal pain 2) greater than the threefold elevation of the serum amylase and/or lipase level 3) computed tomographic evidence of acute pancreatitis * admission within 72 hours of onset of pain * age range of 18-75 * ability to intake soft gels orally exclusion criteria: * severe or critical ap on admission * pregnancy or lactation * a history of allergy to curcumin * acute exacerbation of chronic pancreatitis * prior antioxidant therapy * severe co-morbid illness (liver disease including cirrhosis and hepatitis, renal failure (cr cl \< 30 ml/min)) * active infection * active malignancy * hyperthyroidism * persistent organ failure \> 48 hours (according to marshall score) * on anticoagulant/ anti platelet medications
comparison between arthroscopic debridement and repair for partial-thickness rotator cuff tears

Conditions: Rotator Cuff Tears

Summary: the purpose of this study is to conduct a prospective randomized controlled trial to compare the effects of arthroscopic debridement and repair for ellman grade ii bursal-side partial-thickness rotator cuff tears.the hypothesis was that there would be no difference in prognosis between arthroscopic debridement and repair.

this was a single-center, prospective, double-blinded, randomized controlled trial, comparing arthroscopic debridement and arthroscopic repair for ellman grade ii bptrcts. participants were recruited from september 2017 to april 2019. before initiating the trial, an investigator who was not involved in the study generated a computer-generated randomization list (block length 10, ratio 1:1). allocation concealment was achieved by using opaque, sealed, sequentially numbered envelopes containing details of group assignment. assignment occurred after baseline information was recorded. whereas participants and surgeons were aware of the group assignments, the outcome assessors and data analysts were remained blinded during the study period. operations were performed by the same team of sports medicine surgeons under general anesthesia. for the debridement group, only stump refreshing and surrounding soft tissue cleaning were performed. for the repair group, partial tears were converted into full-thickness tears and sutured. the sample size calculation was based on data from previous studies, where the difference in constant-murray shoulder (cms) score between patients with arthroscopic repair and arthroscopic debridement was 8.81 points (93.90 vs. 85.09) with standard deviations of 5.4 and 21. accepting an α risk of 0.05 and a β risk of 0.2 in a bilateral contrast, the minimum sample size required for each group was 35. to compensate for an estimated 15% loss to follow up, at least 82 patients would be included.

Eligibility criteria:
inclusion criteria: * bursal-side partial-thickness rotator cuff tears (bptrcts) revealed by magnetic resonance imaging (mri) * failed of conservative treatment for more than 3 months * intraoperative arthroscopic confirmed that the tear was ellman grade ii exclusion criteria: * previous surgical surgery on the shoulder * articular-side or intratendinous rotator cuff tears * combined articular-side partial-thickness rotator cuff tears(aprcts) and bursal-side partial-thickness rotator cuff tears (bprcts), or full-thickness rotator cuff tears (rcts) * combined with other shoulder lesions that need to be addressed, such as biceps tendon disorders, labral tears * the presence of other diseases that affect shoulder function * contraindication to arthroscopic surgery or anesthesia

Keywords: partial-thickness bursal-side tear rotator cuff tears arthroscopic debridement arthroscopic repair
dementia care partner hospital assessment tool

Conditions: Alzheimer Disease; Dementia

Summary: the purpose of this study is to see whether an adapted questionnaire called the care partner hospital assessment tool (chat) for care partners of hospitalized patients living with alzheimer's disease and related dementias (adrd) (chat-ad) can help people with dementia receive better care after they go home from the hospital. participants will be a care partner ('family member or friend') who provides unpaid care to a hospitalized adult relative or partner to help them take care of themselves because of dementia. participants can expect to be in this study for 14 days.

the purpose of this study is to adapt chat for care partners of hospitalized patients living with adrd (chat-ad) and evaluate its feasibility and potential efficacy in a pilot randomized clinical trial. findings from this study will enable the lead researcher to launch an independent program of research that aims to (1) improve hospital-based care processes and outcomes for patients living with adrd and their care partners, and (2) make clear the essential caregiving role that so many care partners of patients living with adrd assume. in order to adapt chat, there will be two design teams with key stakeholders from local aging networks and a large academic medical system: one team comprised of previously hospitalized patients living with adrd and their care partners (n=7 dyads) and the second comprised of healthcare system administrators and clinicians (n=7). the team will use a validated participatory human-centered design process in which each team completes 5 co-design videoconference sessions that occur in parallel across 4 months, with 2-3 weeks between each session. upon adaptation of the chat-ad, the study team will partner with a medical and surgical units that are part of a large academic medical system to recruit 128 eligible care partners of hospitalized patients living with adrd, randomized into either the chat-ad plus usual care or usual care-only groups. the team will assess feasibility by examining overall recruitment, attrition, safety, adherence, and implementation satisfaction. to examine efficacy, a validated measure of caregiving preparedness will be obtained pre- and post-intervention.

Eligibility criteria:
inclusion criteria: * provide unpaid care to a hospitalized adult relative or partner to help them take care of themselves because of adrd * 18 years or older exclusion criteria: * non-english speaking
rt-pcr on conjunctival sample for the detection of sars-cov-2 in patients with covid-19

Conditions: SARS-CoV Infection; Pinkeye

Summary: the purpose of the study is to study the detection of sars-cov-2 virus in the conjunctiva of covid-19 patients and the presence or absence of conjunctivitis in these patients


Eligibility criteria:
inclusion criteria: * men and women positive for sars-cov-2 on a rt-pcr test of a sample of respiratory airway * persons over 18 years of age * patients of both sexes * member of a social security scheme * having signed the consent form exclusion criteria: * minors not emancipated, persons out of state to express their consent * participation in intervention research on covid-19 involving experimental treatment * history of chronic disease conjunctiva * patient with one of the one of the criteria of following gravity: 1. en \> or =30/min, 2. pao2/fio2 = or \< 300, 3. confusion and/or disorientation, 4. hypotension (tas90mmhg, requiring aggressive filling), 5. need for a invasive ventilation, 6. septic shock
effect of liraglutide on gastrointestinal absorption of several drugs and potential influence of liraglutide on intragastric ph

Conditions: Diabetes; Healthy

Summary: the trial is conducted in europe. the aim of the trial is to investigate if there is any drug to drug interaction between liraglutide and atorvastatin (lipitor®), lisinopril (zestril®), griseofulvin and digoxin (lanoxin®).


Eligibility criteria:
inclusion criteria: * female subjects if using adequate anti-contraception or is sterile * body mass index (bmi) of 18-30 kg/m\^2 (both inclusive) * good general health as judged by the investigator, based on medical history, physical examination including 12-lead ecg (electrocardiogram), vital signs and blood and urinary laboratory assessments * willing and capable to self-administer a subcutaneous injection exclusion criteria: * history of any clinically significant renal, hepatic, cardiovascular, pulmonary, gastrointestinal, metabolic, endocrine, haematological, neurological, psychiatric disease or other major disorders that may interfere with the objectives of the trial, as judged by the investigator * impaired renal function * blood pressure and heart rate in supine position outside the ranges 90-140 mmhg systolic, 50-90 mmhg diastolic and heart rate 40-100 beats/min * any clinically significant abnormal ecg * active hepatitis b and/or active hepatitis c * positive hiv (human immunodeficiency virus) antibodies * known or suspected allergy to trial product(s) or related products * use of any prescription or non-prescription medication except for paracetamol, nasal spray or drops for nasal congestion, and vitamins within 2 weeks prior to first dosing and during the entire trial period * history of alcoholism or drug abuse during the last 12 months * smoking of more than 10 cigarettes per day, or the equivalent for other tobacco products * habitual excessive consumption of methylxanthine-containing beverages and foods (coffee, tea, soft drinks such as cola, chocolate) as judged by the investigator
effects of resistance training preconditioning on skeletal muscle recovery from a period of disuse in young adults

Conditions: Atrophy, Disuse; Atrophy, Muscular

Summary: the goal of this clinical trial is to compare the effects of resistance training (rt) preconditioning vs no training on disuse-induced atrophy and post-disuse resistance training in young healthy individuals. the main questions it aims to answer are: * to determine if performing rt prior to a period of disuse enhances the regain of strength, skeletal muscle size, and skeletal muscle quality while performing rt after a period of disuse. * to determine if performing rt prior to a period of disuse dampens the maladaptive effects of disuse on muscle size, muscle quality, and strength. * to determine the anabolic and proteolytic mechanisms underpinning the observed outcomes. participants will: 1. perform either 6 weeks of resistance training or maintain an untrained lifestyle 2. perform 2 weeks of limb immobilization induced disuse of a randomized leg 3. perform 6 weeks of resistance training researchers will compare the resistance training preconditioning condition vs the non-trained condition to see if resistance training prior to a period of disuse is beneficial during the disuse period and in the return to training period on skeletal muscle size, strength, and underpinning molecular markers.


Eligibility criteria:
inclusion criteria: * between the ages of 18-30 * free from medical implants in lower extremity that would interfere with low-dose radiation * are not allergic to ultrasound gel or lidocaine * have no or minimal experience with resistance training (less than 1 training session/week for a 1 year period) exclusion criteria: * have been exposed to medically necessary radiation in the past 12 months other than dental x-rays * have known overt cardiovascular or metabolic disease * have a medical condition that would contraindicate participating in an exercise program or donating a skeletal muscle biopsy (e.g. blood clotting disorder, taking blood thinners, etc.) * are undergoing medical treatment for a disease that would interfere physiologically or logistically with study outcomes and/or protocols (e.g. undergoing chemotherapy and/or radiation for cancer treatment) * have consumed supplemental protein, creatine, and/or agents that affect hormone status (e.g. testosterone, growth hormone boosters, etc.) within the previous 2 months.
blood collection sub-study for crc screening in individuals 45-49 at average risk for crc.

Conditions: Colo-rectal Cancer

Summary: the primary objective of this sub-study, 2018-10b, is to collect blood specimens to assess new biomarkers for the detection of colorectal cancer (crc).

subjects who consent to enroll in exact sciences protocol 2018-10, will be asked to participate in this sub-study. subjects enrolled in the exact sciences protocol 2018-10, who provide written informed consent to participate in this sub-study, will have a blood sample collected at enrollment.

Eligibility criteria:
inclusion criteria: 1. subject is currently enrolled in exact sciences protocol 2018-10 2. subject is willing and able to provide a blood sample. 3. subject is willing and able to sign informed consent. exclusion criteria: 1. subject has any condition that in the opinion of the investigator should preclude participation in the study.

Keywords: blood draw
schistosomiasis in senegal

Conditions: Schistosomiasis

Summary: schistosomiasis is a flatworm transmitted from freshwater snails to humans in the tropics. in addition to this infectious disease, tropical developing countries are faced with malnutrition. we propose to alter pesticide and compost use to reduce schistosomiasis and maintain or even improve crop production.

we propose two types of manipulations. bottom-up manipulations will affect snail resources, whereas top-down manipulations will affect snail predators. for the bottom-up manipulations, we will clear schistosoma infections in school children, then remove the primary habitat for snails, the submerged macrophyte ceratophyllum demersum (with proper unmanipulated controls), compost it, apply it to crops, and then quantify reinfection rates and crop yields. the second bottom-up manipulation will be to clear schistosoma infections in school children, apply three agrochemical treatments (status quo control, shift to lower risk herbicides, or eliminate herbicides and fertilizers), and then quantify reinfection rates and crop yields. farmers will be compensated for any loss in yields. for the top-down manipulations, every village will receive prawns that depredate snails. we will clear schistosoma infections in school children, apply three agrochemical treatments (status quo control, shift to lower risk insecticides that don't kill prawns, or eliminate insecticides), and then quantify reinfection rates and crop yields. farmers will be compensated for any loss in yields.

Eligibility criteria:
inclusion criteria: * school age children exclusion criteria: * non-school age children
lipoarabinomannan (lam) in urine for diagnosis of pulmonary tuberculosis in hiv patients

Conditions: TB - Tuberculosis HIV

Summary: a diagnostic validity study in which urinary lam was done in seropositive hiv patients with symptoms suggestive of tb who were included and investigated with battery of tests to reach the final diagnosis.

a diagnostic validity study in which urinary lam was done in seropositive hiv patients with symptoms suggestive of tb who were included and investigated with battery of tests to reach the final diagnosis. the study was conducted at mansoura fever hospital in collaboration with the chest department and clinical pathology department, mansoura university, egypt, from january 2015 to october 2016. ethical approval had been obtained from medical research ethics committee of faculty of medicine, mansoura university (code no: md/138). approval from egyptian ministry of health was taken (no: 1-2016/18). patients signed their written consents after detailed explanation of the study protocol.

Eligibility criteria:
inclusion criteria: * the study included seropositive hiv patients with a new diagnosis of either pulmonary or extra-pulmonary tb, and also included patients who were presented by symptoms suggestive for tuberculosis, changes in chest x ray that not improved by full course of antibiotics or positive tuberculin test ≥ 5 mm. exclusion criteria: * patients on anti-tb drugs or negative screening for sero-positive hiv patients were excluded from the study.
atp release and sympathetic nerve activity in patients with type ii diabetes

Conditions: Type 2 Diabetes

Summary: type ii diabetes (t2d) is characterized by endothelial dysfunction, resulting in a poor tissue perfusion and function as well as an increased risk of cardiovascular events. atp, which is released from the red blood cells, contributes to the regulation of the blood flow and studies have shown that red blood cells taken from t2d patients have an impaired ability to release atp. however, it is not known whether the changes in the atp system is an underlying cause of the poor tissue perfusion observed in t2d. the purpose of project 1 is to test the hypothesis that the deterioration in blood flow in t2d is caused by a reduced release atp from red blood cells, and to test if pharmacological manipulation of camp will normalize atp release, plasma atp levels and thereby blood flow. furthermore, epidemiological studies show a clear link between regular exercise and a reduced risk of serious cardiovascular disease. the extent to which a physically active lifestyle may improve endothelial function in t2d is unknown. regular physical activity improves vascularization and induces an anti-inflammatory environment. both the angiogenic and anti-inflammatory effects of physical activity is in part mediated by substances released from the active muscle. these muscle-derived substances are classified as myokines and have paracrine, autocrine and endocrine effects and may thereby affect distant tissues. the purpose of the project 2 is to investigate whether high intensity interval training may reverse endothelial dysfunction in t2d through increased release of atp and myokines. in individuals with t2d we will determined blood flow in the muscle tissue using advanced ultrasound. in addition, using intravascular and intramuscular microdialysis we will determine atp levels in blood and in the muscle interstitium.


Eligibility criteria:
inclusion criteria: * type 2 diabetics * bmi \>30 * non smokers * physical inactive (less than 2 hours per week) exclusion criteria: * thyroid disorder * known ischemic heart disease (intermittent claudication, angina) * diabetic eye disease * diabetic kidney disease * known heart disease * intake of beta-blockers * blood pressure \> 140/90 * nephropathy and macroalbuminuria gfr measurement * acute illness within the last three weeks * chronic disease, including cancer, heart (ischemic and claudication), liver, kidney and respiratory disorders (asthma) * significant peripheral diabetic neuropathy (severe sensory disturbances) * significant peripheral diabetic angiopathy (former or current foot ulcer) * rheumatological disorders * pregnancy or childbirth within the past three months * alcohol abuse * smokers * use of illegal performance-enhancing drugs (see iaaf list) * injuries and / or surgery within the last 6 months

Keywords: high intensity exercise glycemic control exercise