reducing the duration of untreated psychosis in the united states

Conditions: First Episode Psychosis (FEP); At Risk Mental State (ARMS)

Summary: the goal of this project is to investigate whether a systematic screening approach for individuals with first episode psychosis (fep) can substantially reduce duration of untreated psychosis (dup). the study team will evaluate the feasibility of screening a consecutive help-seeking population entering mental health services in order to facilitate early identification of fep cases, rapid referral to specialty care and engagement in treatment.

psychosis typically emerges in late adolescence or early adulthood, during a vital stage in social and cognitive development, which can have a profoundly adverse impact on an individual's long-term functioning. numerous studies find a substantial delay between the onset of psychosis and the initiation of specialty treatment for first episode psychosis (fep), with the duration of untreated psychosis (dup) typically over one year in the u.s. better detection strategies are needed to improve identification of individuals with fep and to rapidly engage them in coordinated specialty care (csc) aimed at restoring functioning. the onset of psychosis is preceded by a prodromal phase characterized by attenuated psychotic symptoms and decline in functioning. this phase (at-risk mental state: arms) is a potential target for strategies aimed at improving outcome by reducing dup through regular symptom monitoring. this study will investigate whether a u.s. adaptation of a successful detection approach from the netherlands can reduce dup in the u.s. setting. the dutch study found that screening of a consecutive help-seeking population entering mental health services captures significantly more fep and arms cases than clinician referrals from mental health centers. therefore screening may be an effective strategy for identifying individuals with psychotic symptoms earlier on in the course of their illness. this study will implement and evaluate a systematic screening for psychotic symptoms in community mental health clinics in order to facilitate rapid identification and engagement in treatment of individuals with fep. individuals ages 12 to 30 entering child/adolescent and adult community mental health clinics (cmhcs) within mount sinai health system will be screened with the prodromal questionnaire - brief version (pq-b). those who screen positive will be assessed by the structured interview for prodromal syndromes (sips) and referred to stage-specific specialty care. individuals with fep will be referred to csc programs: ontrackny and peer. individuals with arms will be monitored and referred to icanfeelbetter program for arms. dup will be measured for all individuals who meet sips psychosis criteria. the study team hypothesizes that screening for psychotic symptoms in cmhcs will be feasible and acceptable, and that the average dup of fep individuals identified with screening will be less than 3 months, the maximum time between onset of psychotic symptoms and engagement in csc recommended by the world health organization. in order to optimize screening and treatment engagement strategies for reducing dup, the clinical team will identify facilitators and barriers to fep care through in-depth qualitative interviews with patients and caregivers, and by mapping pathways to fep care. the study team will also conduct in-depth qualitative interviews with clinicians to explore their experience with the screening and referral process.

Eligibility criteria:
inclusion criteria: * age 12- 30 * ability to participate in assessments in english * ability to provide informed consent (assent for those under age 18) * meet criteria for psychosis or psychosis risk on sips exclusion criteria: * previous diagnosis of schizophrenia or schizoaffective disorder.

Keywords: screening duration of untreated psychosis (dup) coordinated specialty care (csc) first episode psychosis (fep) at risk mental state (arms) clinical high risk for psychosis (chr)