Kornimate/medical-research-clean huggingface dataset:
recovery guide intervention for recurrent psychiatric hospitalization

Conditions: Schizophrenia; Schizoaffective Disorder; Bipolar Disorder; Psychotic Depression

Summary: the purpose of this study is to determine whether recovery guide support services are effective in promoting recovery and social integration among psychiatrically disabled individuals who experience high rates of inpatient hospitalizations.

the paradigm shift in mental health treatment from a deficit-and institution- based framework to a recovery and community integration frame necessitates new models of "case management" practices. the recovery guide model is just such a model. beyond theoretical frameworks, the effectiveness of recovery guides has not been well studied. it is the intent of this study to conduct a randomized trial examining the effects of recovery guides on community tenure and integration. furthermore, it is the intent of this study to to establish fidelity criteria. comparison(s): recovery guide services in addition to treatment as usual, compared to treatment as usual.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * currently admitted in the yale-new haven psychiatric hospital (ynhph) * a history of two or more prior admissions within the past 18 months * proficient in the use of the english language * a dsm-iv diagnosis of schizophrenia, schizoaffective disorder, psychotic disorder nos, or major depressive disorder with psychotic features exclusion criteria: * inability to give signed, written consent * primary dsm-iv diagnosis of substance abuse/dependence

Keywords: peer support psychiatric disability mutual support psychiatric rehabilitation
effect of nefopam on remifentanil induced postoperative hyperalgesia

Conditions: Patients Undergoing Laparoscopic Gastrectomy

Summary: opioids has been reported to cause hyperalgesia. opioid induced hyperalgesia (oih) is defined as paradoxically lowering the threshold of pain after the exposure of opioid. remifentanil is a short acting opioid that is commonly used during anesthesia and surgery. however, oih was reported to occur after surgery when large amount of remifentanil was administered. on the other hand, nefopam is a centrally acting, non-opioid analgesic. nefopam has been reported to have analgesic and anti-hyperalgesic effect. the investigators hypothesized that nefopam administration could prevent oih or reduce the severity of oih. therefore, the objective of the study is to find out the effect of nefopam on remifentanil induced hyperalgesia in patients undergoing laparoscopic abdominal surgery.


Eligibility criteria:
inclusion criteria: 1. patients undergoing laparoscopic gastrectomy 2. american society of anesthesiologists physical status i or ii 3. aged from 20 to 65 years exclusion criteria: 1. past history of chronic pain 2. drug or alcohol abuse 3. psychotic disorder 4. taking analgesics, anti-epileptics, and anti-depressants. 5. taking opioids within 24 hrs 6. renal disease 7. neuromuscular disease. 8. moderate to severe cardiovascular disease 9. pregnant or breast-feeding

Keywords: opioid-induced hyperalgesia (oih)
evaluation of interventions based on behavioral sciences to reduce episiotomy use

Conditions: Episiotomy; Episiotomy Extended by Laceration; Episiotomy Infection; Episiotomy Wound

Summary: this pilot study seeks to analyze the impact of interventions based on behavioral economics theory (e.g., feedback and information) on episiotomy use.


Eligibility criteria:
inclusion criteria: * healthcare personnel involved in decision-making associated with performing episiotomies who work in the hospital selected to pilot the proposed intervention. exclusion criteria: * healthcare personnel who are not involved in the decision-making process over performing episiotomy during delivery.
india panoptix post marketing study

Conditions: Cataract

Summary: the purpose of this post marketing study is to study the safety and effectiveness of the acrysof iq panoptix intraocular lens (iol) in an indian population.

the study population will consist of adult indian males and females, at least 18 years of age or older at the time of screening, with no ocular pathology that could confound study outcomes, who are advised bilateral cataract extraction and who desire an iol that provides the potential for correction of near, intermediate, and distance vision. both eyes will be implanted. the second eye surgery will take place 15-30 days after the first eye surgery. subjects will be followed for approximately 3 months after the second eye surgery. total individual subject participation will be approximately 4 months. this study will be conducted in india.

Eligibility criteria:
inclusion criteria: * able to comprehend and willing to sign informed consent and complete all required postoperative follow-up procedures; * advised cataract extraction in both eyes and agreed for bilateral implantation of acrysof iq panoptix lens; * preoperative regular keratometric astigmatism of ≤1.0 d in both eyes. exclusion criteria: * pregnant or lactating, current or planned, during the course of the study; * retinal abnormalities (macular degeneration, dystrophy, edema , traction or other pathologies affecting vision); * clinically significant corneal abnormalities; * history of retinal conditions; * previous refractive surgery, including lasik; * glaucoma; * any condition that may not be appropriate to this study, as per the investigator's expert medical opinion. other protocol-specified inclusion and/or exclusion criteria may apply.
associations between low frequency fatigue, jump height and perceptual measures of muscle soreness, fatigue and recovery

Conditions: Fatigue; Physical Exercise

Summary: over the recent years, the increased competitive demands in elite competitive athletes has sparked a heightened interest in monitoring fatigue. given the nature of the soccer game, athletes may experience low-frequency fatigue. until recently, this assessment was restricted to in-lab. however, the emergence of new instruments aiming to allow low-frequency assessment to be carried out on a daily basis, in the context of professional teams. this study aimed to analyze the recovery of low-frequency fatigue, jump height and perceptual responses following competition and investigate possible associations between the objective and subjective parameters.


Eligibility criteria:
inclusion criteria: * elite level youth soccer players, competing in the highest portuguese division exclusion criteria: * older adults * none elite soccer player * play less than 70 minutes of match

Keywords: sports soccer low frequency fatigue
molecular allergen component resolved diagnosis to decide immunotherapy

Conditions: Asthma; Rhinitis, Allergic

Summary: allergen immunotherapy (ait) is used for the control of allergic diseases that are not completely responsive to avoidance strategies and/or pharmacotherapy. it is also considered the main treatment with the potential to modify allergic disease evolution. it's efficacy and safety in allergic rhinitis and asthma is supported by large systematic reviews and is recommended as a cornerstone treatment option in allergic disease. molecular based allergy diagnosis has greatly evolved and the knowledge of molecular allergen sensitization pattern has been used to better define the allergen extract composition of ait. however, uncertainty remains if this strategy is related to an increase of efficacy. regulation of allergen extracts for allergen immunotherapy are currently underway in europe, but there is still lack of standardization of relevant allergens and important differences are seen between allergenic contents. therefore, we aim to evaluate, in a real-life setting, the impact of using molecular-based diagnosis versus standard diagnostic tools in the efficacy of aeroallergen immunotherapy, using a pragmatic randomized controlled trial design and also to address the impact of the discrepancy between individual aeroallergen sensitization profiles and the major allergen molecular content of aeroallergen immunotherapy.


Eligibility criteria:
inclusion criteria: * individuals with medical indication for aeroallergen immunotherapy(ait) for allergic rhinoconjunctivitis or asthma, accordingly to the ait guidelines; * over 5 years of age; * evidence of ige-sensitization (positive skin prick tests and / or serum specific-ige) * patients have indication to ait to house dust mites and/or grass pollen, association with other allergens is not an exclusion criteria exclusion criteria: * previously performed allergen immunotherapy * need the use of molecular allergen diagnosis to decide treatment and diagnostic strategy
microbiome and bariatric surgery

Conditions: Weight Change, Body

Summary: this is a prospective, 24-month, longitudinal study of patients planning to undergo bariatric surgery (roux-en-y gastric bypass or sleeve gastrectomy) in which we aim to identify correlates and predictors of observed weight loss trajectories following bariatric surgery. this approach will expand current knowledge by examining the combined impact of empirically supported behavioral and biological data in a large sample over time. intensive measurement of problematic eating behaviors, mood, and compliance with diet and exercise regimens post-surgery will be analyzed in the context of lterations in parallel with, or in response to, changes observed in the gut microbiota. identifying these post-surgical predictors of weight loss and comorbidity resolution will allow for the development of individualized interventions to optimize surgery-related outcomes.


Eligibility criteria:
inclusion criteria: 1. in evaluation for roux-en-y gastric bypass or sleeve gastrectomy. 2. age 18-65, inclusive exclusion criteria: 1. alcohol or substance use disorder in past year 2. severe psychiatric disorder that may affect ability to complete the protocol 3. regular tobacco use during the last year 4. current medication taken routinely and known to impact factors that may affect the gut microbiome 5. use of any oral or injectable antibiotic in the past month 6. use of commercially available pre/pro biotic in the past month 7. history of significant disease/disorder that would be expected to impact the microbiome of the gut 8. inability to engage in physical activity or dietary monitoring 9. nonprescribed/illicit drug use 10. pregnant or breastfeeding
pilot study on breathing exercises and pulmonary function in children with cerebral palsy: a randomized trial

Conditions: Cerebral Palsy

Summary: this pilot study is a randomized controlled trial aimed at investigating the efficacy of protocolized conductive breathing exercises combined with regular air ventilation, in addition to standard care, on various aspects of health in school-aged children with cerebral palsy (cp). the primary objectives of the study include assessing the effects on pulmonary functions, quality of life (qol), depression anxiety and stress (das) levels, eating-drinking ability (edacs), and severity of drooling in this population. the study compares two groups of participants: one group undergoes protocolized conductive breathing exercises three times per day for five minutes, five days a week, while the other group receives only standard rehabilitation care. evaluations include spirometry parameters ( forced vital capacity \[fvc\] forced expiratory volume in the first second \[fev1\], fev1/fvc ratio and peak expiratory flow \[pef\]. assessments are conducted at the beginning and end of the eight weeks intervention period, with additional evaluations after a 2.5-month washout period. the conductive breathing exercises, developed by dr. andrás pető, the founder of the conductive education system, consist of techniques such as diaphragmatic breathing, deep breathing, and playful forced expiration. respiratory well-being is crucial, particularly in pediatric cp patients, as compromised pulmonary functions can significantly impact overall health. despite this, there is currently a lack of established protocols and research regarding the efficacy of conductive breathing exercises in this specific population. therefore, the this study seeks to address this gap by determining whether a structured regimen of conductive breathing exercises, when added to standard care, can lead to measurable improvements in respiratory health and qol among school-aged children with cp.


Eligibility criteria:
eligibility criteria: inclusion criteria: * children with cerebral palsy (gmfcs i-v) * school-aged 12-22 years, of both genders * teens and adolescents attending continuous standard care * capable of understanding and following commands given by the therapist * children who do not require respiratory support exclusion criteria: * children who have received recent surgical procedures or botulinum toxin injections * children who are unable to perform spirometry

Keywords: cerebral palsy respiratory health spirometry cp quality of life
effectiveness of colchicine among patients with covid-19 infection

Conditions: Coronavirus Infection

Summary: in november 2019, there were a lot of cases of an acute respiratory illness (then named at february 11th as covid_19) which first case was reported in wuhan, china,the sars cov-2 had been spread in a fast way to involve whole world, as it's obvious that colchicine is a drug that is most commonly and widely used to treat and prevent acute attacks of gout, other crystal induced arthropathy,colchicine has important role in inhibiting activation of nlrp3 inflammasome these lead to decrease cytokine production , aim of study to evaluate whether colchicine is effective in the treatment of covid-19 cases. and to measure the effectiveness of colchicine in alleviating and controlling pulmonary and extra pulmonary complications of covid-19

this is an open label, randomize control clinical trial ,the participant will be randomly assign in to two groups ( group a and group b), colchicine (group a) will treat with colchicine tablet alone or add to their current treatment,colchicine 0.5 mg twice daily (reduce to 0.5 mg/day, in patients with low body weight or develop side effects like gastrointestinal symptoms ),for 14 days or until symptoms subsides, while the control group will treat according to usual treatment guideline in covid-19.

Eligibility criteria:
inclusion criteria: 1.patients diagnosed clinically or by rt-pcr in nasopharyngeal swab specimens and/ or lung involvement confirm by computed tomography scan compatible with covid-19patients 2.age between 18 year and 70 years, 3.body weight \> 50 kg, 4.with written informed consent from patients or relatives. - exclusion criteria 1 sensitivity to any medications of regimens, 2.e gfr less than 30. 3.pregnancy. 4.malignancy . 5.participating in another clinical study and refusing to participate in the study at a later date or later, and they are already taking colchicine for other diseases . -

Keywords: covid-19, colchicine erbil,iraq
targeting physical activity to improve cardiovascular health in type 2 diabetes

Conditions: Motor Activity; Health Behavior; Diabetes Mellitus, Type 2

Summary: this study plans to learn more about physical activity and physical function in sedentary older adults with type 2 diabetes.

the purpose of this study is to conduct a randomized controlled trial with 1:1 patient-level randomization to an evidence-based physical activity program intervention versus usual care in sedentary older adults with type 2 diabetes in two primary care clinic sites.

Eligibility criteria:
inclusion criteria: * diagnosis of type 2 diabetes * sedentary individual, performing \<20 minutes of physical activity on \<3 days/week exclusion criteria: * dementia (folstein mini-mental status exam \<24) or clinical diagnosis * excessive fall risk: can not hold semi-tandem stance for \>10 seconds * type 2 diabetes-related safety concerns: prior diabetic foot ulcer, charcot foot, asymptomatic hypoglycemia * severely uncontrolled hypertension (bp \>180/100) * excessive hearing or visual impairment for counseling * limited life expectancy: active treatment for malignancy * performs regular physical activity \>20 minutes on \>3 days/week

Keywords: physical activity physical function physical impairment sedentary lifestyle
adhesion performance study of lidocaine topical system 1.8% compared to generic lidocaine patch 5% in healthy, adult, human subjects

Conditions: Healthy

Summary: an open label, randomized, two-treatment, two-period, single-dose study evaluating the product adhesion in healthy, adult subjects using ztlido 1.8% topical system and a generic lidocaine patch 5%


Eligibility criteria:
key inclusion criteria: * must be healthy based on by medical history, laboratory work, ecg, and physical exam with bmi range between 18.00 and 30.00 kg/m2 inclusive. * be at least 18 years of age * if childbearing potential, use of acceptable form of birth control * in the case of females of childbearing potential, have a negative serum pregnancy test key exclusion criteria: * allergy or known hypersensitivity to lidocaine, amide-type local anesthetics, or any component of the product formulation * any major medical illness 3 months prior or any significant history or ongoing chronic medical illness * subjects with conditions that might affect application of the product or its adhesive properties (including psoriasis, eczema, atopic dermatitis, damaged or irritated epidermal layer, and excessive hair or oil on the skin) * history of addiction, abuse, and misuse of any drug * use of local anesthetics of antiarrhythmic drugs (such as tocainide or mexiletine) within 14 days prior to product application
a study of the safety and efficacy of synvisc and depo-medrol in patients with osteoarthritis of the hip

Conditions: Osteoarthritis, Hip; Musculoskeletal Diseases

Summary: this is a clinical study to investigate the safety and efficacy of synvisc and depo-medrol in treating patients with osteoarthritis (oa) of the hip.


Eligibility criteria:
inclusion criteria: * patients with symptomatic osteoarthritis pain of hip exclusion criteria: * patients with current or prior conditions or treatment that would impede measurement of efficacy and safety

Keywords: osteoarthritis of the hip musculoskeletal diseases
effects of glyx-13 on learning and memory in healthy individuals and those with psychiatric illness

Conditions: Psychiatric Illness; Healthy

Summary: the present study proposes to evaluate the potential cognitive enhancing effects of glyx-13, an nmdar partial agonist, among a group of healthy adults and those with psychiatric illness on a series of functional magnetic resonance imaging (fmri) learning and memory tasks.

in a single blind randomized parallel group design, we will evaluate the whether a single dose of glyx-13 vs. placebo increases cognitive performance on tasks of learning, declarative memory, and working memory, and associated task-related increases in blood oxygen level-dependent (bold) activation in hippocampus and dorsolateral prefrontal cortex, respectively. positive findings will provide biomarker evidence for glyx-13 effects on neural systems underlying these cognitive processes.

Eligibility criteria:
inclusion criteria: for all individuals * male and female subjects * ages 18 - 40 years * general intellectual abilities falling broadly within the average range (estimated intelligence quotient (iq) between 80 - 119) * sufficient ability to understand study requirements and provide written informed consent for patients -diagnosis of schizophrenia or schizoaffective disorder exclusion criteria: for all individuals: * history of neurologic disorder or systemic medical condition that may interfere with central nervous system function * history of seizures * history of heard injury with loss of consciousness or concussion * positive screen for drugs of abuse: cocaine, marijuana, phencyclidine, ketamine, opioid, or other agent that is being abused in the opinion of the investigator * females who are currently pregnant or plan to become pregnant during the study period * history of allergy, sensitivity, or intolerance to n-methyl-d-aspartate receptor (nmdar) ligands including ketamine, dextromethorphan, memantine, methadone, dextropropoxyphene, or ketobemidone * history of any ferromagnetic object in the body * presence of any medical device or implant for which mri is contraindicated including cardiac pacemaker, aneurysm clip, cochlear implant, copper intrauterine device (iud), neurostimulator, or any other device deemed unsafe * bullet or shrapnel in body * metallic braces or permanent retainer * significant claustrophobia for healthy individuals * personal history of any axis i disorder according to the structured clinical interview for the dsm-5 (scid-5) criteria * history of treatment with antidepressant, antipsychotic, stimulant,sedative/ hypnotic, mood stabilizing, or anticholinergic medications or lithium * history among first-degree family members of any psychotic illness or major mood disorder (e.g., major depressive disorder, recurrent; bipolar i or ii disorder) for patients * treatment with clozaril * change in medication within 1 month * hospitalization within 1 month

Keywords: healthy individuals schizophrenia schizoaffective disorder learning memory cognitive enhancement fmri
a transversal study for the french validation of two assessment tools of gambling related cognitions.

Conditions: Gambling

Summary: this study is divided into two stages. in the first stage, students from the university of nantes completed the two assessment tools of gambling related cognitions (gabs : gambling attitudes and beliefs survey ; grcs : gambling related cognitions scale), and a reference tool for gambling problem severity (sogs : south oaks gambling screen). in the second stage, consecutive pathological gamblers seeking treatment at the university hospital of nantes completed the three questionnaires. only questionnaires from participants who reported gambling at least one time in the past year were kept for analyses.responses of students gamblers and pathological gamblers presenting for treatment have been compiled for analysis.the main objective of the study is to validate the french adaptations of the gabs and the grcs, and to explore their psychometric properties and structures.

this study is divided into two stages. in the first stage, students from the university of nantes completed the two assessment tools of gambling related cognitions (gabs : gambling attitudes and beliefs survey ; grcs : gambling related cognitions scale), and a reference tool for gambling problem severity (sogs : south oaks gambling screen). in the second stage, consecutive pathological gamblers seeking treatment at the university hospital of nantes completed the three questionnaires. only questionnaires from participants who reported gambling at least one time in the past year were kept for analyses. responses of students gamblers and pathological gamblers presenting for treatment have been compiled for analysis. the main objective of the study is to validate the french adaptations of the gabs and the grcs, and to explore their psychometric properties and structures. the recruitment period for the first stage is comprised between march 2008 and august 2008. the recruitment period for the second stage started in september 2008.

Eligibility criteria:
inclusion criteria: * to be more than 18 years old (the legal age to gamble in france) exclusion criteria: * none

Keywords: gambling cognitive distortions assessment tool validation french