Kornimate/medical-research-clean huggingface dataset:
study to assess the use of a simple lab test to screen for rickets in children

Conditions: Rickets

Summary: some experts recommend that all breastfed babies receive supplemental vitamin d. the purpose of this study is to determine the rate of vitamin d use in breastfed babies, the recommendations of pediatricians regarding vitamin d, and the impact on these recommendations on parental choice of vitamin d. in addition, in preparation for a large study to see how many breastfed children who don't receive supplemental vitamin d have rickets, in this study we will determine if a simple blood test, an alkaline phosphatase level, could be used to screen for rickets. parents of children 6-23 months old are eligible to complete feeding surveys and children 6-15 months old who were breastfed for at least the first six months of life and didn't routinely receive vitamin d are eligible for alkaline phosphatase levels. we postulate that most breastfed babies don't receive supplemental vitamin d, and that alkaline phosphatase levels will only be abnormal in a few babies who will have evidence on x-ray of rickets.

the puget sound pediatric research network (psprn) is a practice-based research network of pediatricians in the puget sound area and at the university of washington and children's hospital and regional medical center. the network has extensive experience in conducting large studies on contentious issues that are pertinent to children, their parents, and primary care providers. in 2004, vitamin d supplementation was recommended for all exclusively breastfed infants. this recommendation was based on sporadic reports over the last 30 years of vitamin d deficient rickets in infants and toddlers who have been exclusively breastfed. the recommendation has been controversial because it might undermine efforts to promote breastfeeding, and because the prevalence of rickets in these patients is unknown. psprn proposes to conduct a preliminary study to determine the feasibility of a larger planned project by the network to determine the prevalence of rickets in breastfed infants and toddlers who do not receive supplemental vitamin d. systematic surveys will be conducted in psprn practices to determine current levels and trends in vitamin d supplementation. current practices of psprn pediatricians regarding supplementation, and their effect on parents, will also be assessed. the utility of a serum alkaline phosphatase level as a screening test for vitamin d deficient rickets will be determined in the proposed study by obtaining levels on approximately 300 patients, 6-15 months old, seen by psprn practitioners, who have been breastfed. in addition to assessing possible methodologies for the larger project, the preliminary study is designed to yield standalone results with important implications.

Eligibility criteria:
inclusion criteria: * predominantly breastfed for first 6 months of life * no routine use of vitamin d during first six months of life * singleton birth * birth at \> 35 weeks gestation exclusion criteria: * formula fed * significant formula supplementation

Keywords: breastfeeding vitamin d supplementation rickets
safety of celecoxib in patients with crohn's disease

Conditions: Crohn's Disease

Summary: the investigators will select 60 people who are 18-70 years of age with crohn's disease and randomly assign them to receive an 8-week trial of celecoxib and an 8-week trial of a placebo. there will be a 1-week interval or "wash-out" between trials when the participant does not take any study medication. the investigators will monitor the participants for 18 weeks after they start the medication and observe their crohn's disease activity, assessing for flare-ups or exacerbations in the disease and other possible side effects of celecoxib. based on these observations, a determination will be made by the investigators as to the safety of celecoxib. if celecoxib is found to be safe, then it may provide physicians with a medication that they can prescribe for people who have crohn's disease and experience chronic pain from arthritis and arthralgia.

please refer to brief summary (above).

Eligibility criteria:
inclusion criteria: 1. greater than 18 years of age or less than 70 years of age 2. confirmed diagnosis of crohn's disease 3. inactive disease (cdai scores at baseline \<150) or active disease (cdai scores at baseline \<200). exclusion criteria: 1. pregnant, nursing mothers and women of childbearing potential who are not using reliable contraception (i.e.: oral contraceptive pill \[ocp\], intrauterine device \[iud\], norplant) 2. enrolled in any other study involving non-steroidal anti-inflammatory drug (nsaid) medications 3. nsaid use at time of study 4. baseline moderate to severe crohn's disease activity (cdai \> 200) 5. current treatment of less than 6 months with mercaptopurine (6 mp) or immuran. 6. treatment with current crohn's medication for a period of less than 3 months 7. surgery for crohn's disease (within 1 month) 8. known sensitivity to celecoxib, nsaids, or sulfonamides 9. history of gastritis, gastrointestinal bleeding, or peptic ulcer disease 10. advanced kidney disease 11. severe hepatic impairment 12. subjects currently taking angiotensin-converting enzyme (ace) inhibitors, furosemide, fluconazole, lithium, corticosteroids, and warfarin
quantitative mr parameters in non-myelopathic degenerative cervical spinal cord compression: a longitudinal study.

Conditions: Degenerative Cervical Spinal Myelopathy; Cervical Spinal Cord Compression

Summary: quantitative magnetic resonance imaging parameters as predictors of outcome for non-myelopathic degenerative cervical cord compression: a longitudinal study

the study uses semi-automated detection of anatomical metrics (morphometric parameters) and dcc with spinal cord toolbox (sct). this method have been proven more reliable than expert's manual rating, the introduction of the automated method will be utilized in the future multi-centre and longitudinal studies. routine anatomical morphometric parameters such as compressive ratio (cr) and cross-sectional area (csa) will be acquired along with microstructural and metabolic metrics obtained with validated dmri and mrs methods, remote cervical cord atrophy from voxel-based mri volumetry, t2\* white matter/gray matter (wm/gm) signal-intensity ratio, and also metrics obtained with novel intravoxel incoherent motion (ivim) method will predict progression of nmdcc into symptomatic dcm. "natural course" (i.e., speed of progression) of the severity of dcc assessed with anatomical and advanced mri/mrs metrics is not known but may play a role in the progression from nmdcc to symptomatic dcm. aims of this project are: to determine independent predictors of unfavourable outcome - progression into symptomatic degenerative cervical myelopathy (dcm) - among quantitative mri parameters and compare them with already defined clinical and electrophysiological predictors. to evaluate the "natural course" of mri descriptors of compression and its severity, and the correlation between progression and development of symptomatic dcm. to implement automated detection of cervical cord compression using spinal cord toolbox based on automatically computed morphometric parameters.

Eligibility criteria:
inclusion criteria: subject with no contraindication to mr examination. clinically asymptomatic cervical spinal cord compression or subjects with no spinal cord compression. exclusion criteria: * a subject will be excluded if he/she has a contraindication to mr scanning implanted metal clips or wires of the type which may concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field. * pregnancy * claustrophobia
sutures versus glue in laparoscopic port site closure.

Conditions: Cosmetic Outcome; Infection; Cost

Summary: cosmesis postoperatively is an important consideration for both patients and surgeons and consequently surgeons have become increasingly interested in replacing conventional sutures by means of adhesive bonds for the closure of skin wounds. therefore the investigators are using two different close techniques for laparoscopic wounds. these are; 1. sutures with steri-strips and 2. adhesive bond.


Eligibility criteria:
inclusion criteria: * elective laparoscopic surgeries. emergency laparoscopic surgeries. exclusion criteria: * contaminated wounds. immunocompromised patients. diabetic patients. history of keloid scarring.
study to evaluate safety, pharmacokinetics, and antiviral activity of lenacapavir administered subcutaneously in human immunodeficiency virus (hiv) -1 infected adults

Conditions: HIV-1 Infection

Summary: the primary objectives of this study are: part a: to evaluate the short-term antiviral activity of lenacapavir (formerly gs-6207) with respect to the maximum reduction of plasma hiv-1 rna (log10 copies/ml) from day 1 through day 10 compared to placebo in hiv-1 infected adults who are antiretroviral treatment naive or are experienced but capsid inhibitor (cai) naive. part b: to evaluate the short-term antiviral activity of tenofovir alafenamide (taf) with respect to the maximum reduction of plasma hiv-1 rna (log10 copies/ml) from day 1 through day 10 in hiv-1 infected adult subjects who are antiretroviral treatment naïve or are experienced but without resistance to taf.


Eligibility criteria:
key inclusion criteria: * plasma hiv-1 rna ≥ 5,000 copies/ml but ≤ 400,000 copies/ml and cd4+ cell count \> 200 cells/mm\^3 * treatment naive or experienced but cai (for part a only) and integrase strand transfer inhibitor (insti) naïve, and have not received any antiretroviral therapy (art) within 12 weeks of screening * screening genotype report must show sensitivity to b/f/taf to allow its initiation on day 10 * screening genotype report must show sensitivity to at least one agent in either non-nucleoside reverse transcriptase inhibitor (nnrti) or protease inhibitor (pi) class to allow its use as part of standard of care oral antiretroviral treatment in the future * have adequate renal function (estimated glomerular filtration rate ≥ 70 ml/min) * no clinically significant abnormalities in electrocardiography (ecg) at screening * willing to initiate b/f/taf on day 10 after completion of all assessments key exclusion criteria: * pregnant or lactating females note: other protocol defined inclusion/exclusion criteria may apply.
cohort study of new prognostic factors with peripheral blood and bone marrow evaluation at the time of diagnosis and during treatment or thereafter in acute leukemia

Conditions: Acute Leukemia

Summary: the objective of this study is to evaluate the prognostic factors of acute leukemia patients and to invent the molecular genetic test for sensitive detection of minimal residual disease, and thereby this study would contribute to plan the risk adapted treatment. patients will have samples of blood and/or bone marrow collected during diagnosis process, treatment and/or thereafter


Eligibility criteria:
inclusion criteria: * patients diagnosed with acute leukemia in severance hospital. * both genders of 16 years and older * sign a written informed consent document exclusion criteria: * no comprehension or willingness to sign a written informed consent document.
niacin/laropiprant tablet for south and southeast asians with low high-density lipoprotein cholesterol (ldl-c) at risk for cardiovascular disease (mk-0524a-108)

Conditions: Dyslipidemia

Summary: the study will evaluate the use of extended release niacin/laropiprant (ern/lrpt) combination tablets in a primary prevention population currently not taking or eligible for lipid-modifying therapy (lmt); the population will comprise participants with low to moderate risk for coronary heart disease (chd), low high density lipoprotein cholesterol (hdl-c), low density lipoprotein cholesterol (ldl-c) at or below goal level, and normal or mildly elevated triglyceride (tg) levels.


Eligibility criteria:
inclusion criteria: * lmt ineligible * participants must meet the lipid criteria of "low to moderate chd risk" as defined by national cholesterol education program adult treatment panel iii framingham point scores (ncep atp iii) * hdl-c \<40 mg/dl (1.03 mmol/l) in males and \<50 mg/dl (1.29 mmol/l) in females * triglyceride (tg) level \<300 mg/dl (3.39 mmol/l). * fasting serum glucose (fsg) at visit 1 and visit 2 \<126 mg/dl (\<7 mmol/l) * hemoglobin a1c (hba1c) level \<6.5% * participant willing to use acceptable method of contraception during the study, including the 14-day follow-up period exclusion criteria: * history of malignancy ≤5 years prior to signing informed consent, except for adequately-treated basal cell or squamous cell skin cancer or in situ cervical cancer * participation in a study with an investigational compound (non-lipid-modifying) within 30 days * pregnant, breastfeeding, or expecting to conceive, or father a child during the study, including the 14-day follow-up period * consumption of more than 3 alcoholic drinks on any given day or more than 14 drinks per week * engages in or plans to engage in vigorous exercise or an aggressive diet regimen during the study * diabetes mellitus, based on medical history, fsg ≥126 mg/dl (7 mmol/l), and hba1c ≥6.5% * risk factors for coronary heart disease * active or chronic hepatobiliary or hepatic disease * active peptic ulcer disease within 3 months of visit 1 * history of hypersensitivity or allergic reaction to niacin or niacin-containing products * episode of gout within 1 year of visit 1, unless currently stable on allopurinol * taking an lmt (including statins, bile acid sequestrants, fibrates and niacin \>50 mg as monotherapy or coadministered with other lmts) * use of over-the- counter or traditional medicine (e.g. red yeast rice products) for lipid-lowering * receiving treatment with systemic corticosteroids (unless on stable therapy for at lest 6 weeks for replacement for pituitary/adrenal/hypogonadal disease) * uncontrolled illness or infection
abnormal plantar pressure in patients with diabetes

Conditions: Diabetes Complications

Summary: the prevalence of abnormal plantar pressure distribution (apd) and its connection with various factors among patients with diabetes is not known. the purpose of this study was to evaluate the prevalence of the apd and its connection with selected factors among patients with diabetes.

the abnormal plantar pressure distribution (apd) plays a key role in the formation of plantar calluses which are responsible for diabetic foot ulcer. the knowledge of apd is necessary to plan proper prevention in the group of patients with diabetes mellitus (dm). medical records from previous patients' visits of non-ulcer patients with diabetes were retrospectively analysed. the relationship between apd, obtained during a pedobarographic test as a semi-quantitative assessment with colourful print analysis, and neuropathy, gender, age and bmi was searched.

Eligibility criteria:
inclusion criteria: * subjects with diabetes mellitus diagnosis * citizens * no previous foot ulceration and/or foot surgery exclusion criteria: * previous foot ulceration and/or foot surgery

Keywords: diabetic foot pedobarography diabetic neuropathy plantar pressure
pet in guiding cervical lymphadenectomy (ectop-2003)

Conditions: Esophageal Cancer

Summary: esophageal cancer is the eighth most common cancer around the world, with more than 450000 new cases per year. esophagectomy with radical lymphadenectomy (2-field lymphadenectomy) is the mainstay of treatment in many countries for patients with esophageal cancer. to improve the survival, 3-field lymphadenectomy combined with cervical lymphadenectomy was started in 1980s. more potential positive lymph nodes were found during more extended lymphadenectomy, offering more accurate tnm staging, affecting consequent treatment. however，3-field-lymphadenectomy was associated with increased surgical morbidity and mortality. positron emission tomography (pet) is used for detecting distant metastases and lymphatic involvement. the aim of the study is to evaluate the role of pet in predicting cervical lymph metastases of patients with thoracic esophageal squamous cell carcinoma, and to determine if investigators can use pet to guide future cervical lymphadenectomy. (eastern cooperative thoracic oncology projects 2003, ectop-2003)

from june, 2018, a total of 110 patients with thoracic esophageal carcinoma will be recruited in 4 hospital in china. participants with resectable esophageal cancer will have pet/ct scan before three-field lymphadenectomy. lymph nodes will be recored according to the anatomy site. lymph nodes metastasis diagnosed by pet/ct and by postoperation pathological examination will be compared to evaluate the role of pet/ct in guiding the extent of lymphadenecomy and surgical approach.

Eligibility criteria:
inclusion criteria: 1. histologically proven esophageal cancer 2. resectable ct1-t3/n0-n1 thoracic，operable esophageal lesion. staging investigations including esophagogastroscopy, chest and abdominal ct scan, and barium swallow 3. karnofsky performance status greater than or equal to 80% 4. acceptable pulmonary and cardiac function. 5. acceptable hepatic, renal and bone marrow function exclusion criteria: 1. low performance status(karnofsky score \<80%) 2. past history of malignancy 3. unresectable advanced disease(t4 or m1a,m1b) 4. patients with any other serious underlying medical condition that would impair the ability of the patient to receive or comply with protocol treatment 5. medically unfit for surgical resection 6. pulmonary reserve inadequate to undergo thoracotomy and extensive mediastinal lymphadenectomy. 7. a significant history of unstable cardiovascular disease that in the opinion of the treating physician should preclude the patient from protocol treatment. 8. uncontrolled diabetes mellitus or uncontrolled infection, including hiv or interstitial pneumonia or interstitial fibrosis. 9. significant psychiatric illness that would interfere with patient compliance 10. severe hepatic cirrhosis or with serious renal disease unacceptable for surgery 11. salvage surgery after definitive chemoradiotherapy 12. patients have neoadjuvant chemoradiotherapy 13. above the age of 80 years 14. unreliable for follow up

Keywords: positron emission tomography cervical lymphatic metastasis
music therapy for people with schizophrenia and relates psychosis.

Conditions: Schizophrenia; Psychosis

Summary: treatment of symptoms, rehabilitation of cognitive deficits, improvement of social functioning and quality of life in schizophrenia and other psychoses are approached through a comprehensive strategy that combines psychopharmacology with psychosocial interventions. however, despite the efficacy of these interventions, this is not the same in all patients, and a large percentage do not achieve functional recovery.

the aim of this research is to carry out a randomized trial on the effects of a music therapy (mt) program, implemented in addition to the usual pharmacological and psychosocial rehabilitation (tau), on symptoms, self-esteem, internalized stigma, social cognition, social functioning and the quality of life in these patients.

Eligibility criteria:
inclusion criteria: * the patients will be diagnosed with schizophrenia or schizoaffective disorder in accordance with dsm-iv-tr criteria using the structured clinical interview for dsm-iv-tr (scid-i). * the patients will all clinically stable with a diagnosis of schizophrenia and regularly attended in the state approved centre for psychosocial attention creap (centro de referencia estatal para la atención psicosocial) in valencia (spain). exclusion criteria: * previous brain damage * substance abuse in the last year * display of mood disorders * organic or substance based mental disorders * disrupted symptomatology * serious symptoms with difficulty in understanding the implications of informed consent and not replying in the interviews and assessment questionnaires

Keywords: music therapy psychosis adjunct therapy psychosocial rehabilitation recovery
research on gut microbiome and metabolomics alterations in c.difficile infected ibd patients

Conditions: Inflammatory Bowel Diseases; Clostridium Difficile Infections; Microtia

Summary: the goal of this research is to compare alterations of gut microbiota and fecal metabolomics alterations between inflammatory bowel disease patients infected with or without clostridioides difficile. the main questions it aim to answer are: which bacterial genus or fecal metabolites can discriminate ibd patients infected or more likely to be infected with clostridioides difficile and their role in the pathogenesis of clostridioides difficile. type of study: observational study participant population/health conditions 1. population diagnosed with ulcerative colitis or crohn's disease 2. having diarrhea participants will be included in this research. if there is a comparison group: researchers will compare healthy people without ibd or any diarrhea to see if disease or diarrhea would affect the gut microbiota and metabolites.


Eligibility criteria:
inclusion criteria: * inpatients diagnosed with ulcerative colitis or crohn's disease in renji hospital * age from 18 to 75 years old exclusion criteria: * other infection caused diarrhea * other metabolic diseases or inflammatory diseases * patients who are not able to send back samples 4-6 weeks after therapy

Keywords: inflammatory bowel disease clostridium difficile disease
validation of the turkish translation of the london speech evaluation scale

Conditions: Speech Intelligibility; Speech Disorders; Head and Neck Cancer; Speech Dysfunction; Speech

Summary: purpose of the study is the validation and cultual adaptation of the turkish translation of the london speech evaluation scale (lse-t), so that it would be used as an assessment tool for turkish head and neck cancer patients. there is no validated turkish version of lse to measure severity of perceptual speech in head and neck cancer patients.

the speech function is a multidirectional process that depends on complex neuro-muscular network. the function can be evaluated using instrumental, such as voice analysis computer programmes, scales, or well structured questionnaires. there are many scales for assessment of perceptual speech but there is no validated for head and neck patients. the study will assess the construct validity and adaptation of the turkish translation of speech specific perceptual speech evaluation as known as london speech evaluation scale. the investigators developed the turkish translation of this scale (lse-t), according to the cross-cultural adaptation guidelines. two translators translated the lse into turkish and a native english language speaker reverse-translated it into english. the back translation was sent to the original author for proofreading. the lse scale consisted of 6 parameters and 4 scores related with perceptual speech in head and neck cancer patients.

Eligibility criteria:
inclusion criteria: * able to speak, read, understand and write in turkish * history of oral, orofarengeal cancer * volunteers who accept the informed consent exclusion criteria: * mental disorders * cognitive limitations * able not to speak, read, understand and write in turkish * underwent any surgery last six month * permanent tracheostomy, total laryngectomy * pregnancy * out of age 18-70 years old * adults who do not accept the informed consent.

Keywords: perceptual speech articulation neck cancer