Kornimate/medical-research-clean huggingface dataset:
clinical characteristics, treatment and prognosis of chest tightness variant asthma

Conditions: Asthma; Chest Syndrome; Clinical Anxiety; Clinical Depression; Lung Function; Quality of Life; Eosinophilia; Nitric Oxide; Airway Responsiveness; Induced Sputum

Summary: asthma, abbreviation for bronchial asthma, is one of the common chronic airways disease that threatens human health. typical symptoms of asthma are recurrent wheezing, shortness of breath, chest tightness and cough, usually occurring at night or early morning. however, there are still some patients with only persistent clinical manifestations of chest tightness. concerned about this group of patients, we presented a subgroup of bronchial asthma, namely, chest tightness variant asthma (ctva). this asthma subgroup usually lacks asthma-specific clinical features such as wheezing, shortness of breath, wheezing, and therefore often misdiagnosed for a long time. in order to further understand the clinical characteristics, pathogenesis, and prognosis of patients with ctva, we conducted a national multicenter observation study to further understand ctva. finally, we plan to clarify whether ctva is a relatively independent asthma phenotype. meanwhile, reducing misdiagnosis and perform an appropriate treatment of ctva.


Eligibility criteria:
inclusion criteria: 1. all subjects agreed to participate, understand the project, observe the use of drugs, agree to follow-up, and signed informed consent; 2. the age of more than 14 and less 80 years old, gender and ethnicity are not limited; 3. the duration time was more than 6 months,and chest tightness was the only complaint, without breathing, short of breath, chronic cough; 4. no wheezing; 5. a diagnosis of asthma supported by one or more other characteristics: * bronchial provocation test positive; * improvement in forced expiratory volume at one second (fev1) of more than 12% and 200 ml after inhaled salbutamol; * variability in diurnal peak expiratory flow (pef) of more than 10% for one day during one week. 6. bronchodilator and glucocorticoid treatment is effective; 7. exclude the following diseases by the corresponding doctors: coronary heart disease, myocarditis, heart failure, gerd, neuromuscular disease, and mental disease. exclusion criteria: 1. can not cooperate with related inspection or for other reasons; 2. patients with chronic obstructive pulmonary disease, interstitial pneumonia, active tuberculosis, community acquired pneumonia, lung cancer, bronchiectasis, cor pulmonale, pulmonary embolism, and accompanied with serious systematic disease (such as coronary heart disease, myocarditis, heart failure, gastroesophageal reflux disease, neuromuscular disease, etc); 3. history of drug abuse, alcohol abuse or anesthesia or with a history of mental illness (schizophrenia, obsessive-compulsive disorder, depression) and against personality, motivation, suspicious, or other emotional or mental issues that may affect participation in the study; 4. taking part in other drug clinical trial project, or drop out less than 3 months; 5. during pregnancy, lactation women; 6. obvious abnormal of high resolution ct.
non-invasive near-infrared spectroscopy (nirs) versus invasive licox intracranial pressure

Conditions: Brain Injuries

Summary: researchers are trying to assess how accurately and safely nirs non-invasive monitoring can detect changes in intracranial pressure to determine if this noninvasive device can be used instead of invasive monitoring with licox in the future.


Eligibility criteria:
inclusion: * subjects with acute brain injury who are age ≥ 18 * glasgow coma scale score (gcs) ≤ 8 * neuroimaging concerning for icp crises, or have active icp treatment * have licox brain tissue oxygen monitor placed as standard of care treatment exclusion: * cns infection * bleeding diathesis or thrombocytopenia \< 50,000 platelets * subjects with subdural hematomas who have had surgical decompression and bone flap removal
knowledge and attitude in perioperative erythrocyte transfusion in medical personnel in siriraj hospital

Conditions: Transfusion-dependent Anemia

Summary: this study is designed to explore the correlation between knowledge and attitude in perioperative erythrocyte transfusion in medical personnel.

inappropriate erythrocyte transfusion is still have high incidence even lots of the transfusion guidelines and researches was launched. unnecessary or delayed transfusion can cause morbidity and mortality. this study is descriptive research, questionnaire based survey conducted to explore the correlation between knowledge and attitude in perioperative erythrocyte transfusion in medical personnel in siriraj hospital.

Eligibility criteria:
inclusion criteria: * post-graduated medical personnel in siriraj hospital exclusion criteria: * post-graduated medical personnel in siriraj hospital who refuse to participate
safety and efficacy assessment of using the zlock facet stabilization system

Conditions: Low Back Pain

Summary: the zlock facet stabilization system is a fixation device intended to provide posterior stability in the lumbar spine fusion procedure. the system can be placed either as an adjunct to an inter-vertebral anterior cage or as stand-alone with/ without additional decompression of the dural sac or nerve roots as appropriate for the specific patient and surgeon's discretion. the zlock implant is placed inside the facet to stabilize the motion and enhance the bony fusion of the joint. the zlock facet stabilization system is intended for single-level stabilization of a spinal motion segment in order to promote bony fusion of the joint. the zlock system is indicated for use from l1-l2 to l5-s1 joints. the zlock implant is inserted into the facet joint space while adapting to the joint's changing geometry. stabilization is achieved by a firm grip of each joint bone and resisting any relative motion. the zlock implant is placed percutaneously and requires only one incision per side, thereby reducing the invasiveness procedure duration and shortening the recovery period. this pivotal study was designed in order to assess the safety and effectiveness of the zlock system.


Eligibility criteria:
inclusion criteria: 1. patient is scheduled for spine surgery with at least one of the following: * degenerative spondylolisthesis grade 1; * mild to moderate stenosis; * degeneration of the facets. 2. when used stand-alone disc height should be maximum 50% of the adjacent disc height. 3. 18\< age \<75 4. weight \< 100kg 5. signed informed consent form 6. at least 3 months of unsuccessful conventional treatments exclusion criteria: 1. fusion procedure performed or required in more than one motion segment. 2. acute or chronic spinal infections. 3. osteoporosis when used in adjunct to an anterior interbody cage (dexa \< -2.5). 4. absence of posterior spinal elements including the pedicle, pars interarticularis, facet joints, spinous process and the majority of the lamina which make it unstable or not possible to place. 5. any entity or conditions that totally preclude the possibility of fusion, i.e. cancer or kidney dialysis. 6. obesity (bmi ≥30) 7. unilateral application of device, except in combination with anterior interbody cages. 8. known sensitivity to titanium. 9. alcoholism, or drug abuse 10. subject with a cardiac pacemaker or other implanted electro medical device 11. women who are either pregnant or nursing at the time of screening (to be verified by test in case of woman of child-bearing potential that do not practice medically acceptable methods of contraception) 12. concurrent participation in another clinical trial using any investigational drug or device. 13. mental disorders. 14. tumor 15. fracture or other instabilities of the posterior elements.

Keywords: stabilization facet arthritis spondylolisthesis stenosis
effect of a multi-component education program on salt reduction in adults

Conditions: Blood Pressure; Hypertension

Summary: excess salt intake is a major contributor to high blood pressure, the leading individual risk factor for cardiovascular events, such as stroke, myocardial infarction and heart failure. according to physa study, salt intake in portugal remains much higher (10.7 g) than recommended by the international health organisations, indicating the need for effective implementation of salt reduction interventions. in portugal the main source of daily salt intake is added salt during cooking, and salt content in bread, cheese and processed meat. the objective of this study is to determine the effectiveness of a dietary education program tailored for salt reduction. to assess the effectiveness of the salt reduction program the investigator's will measure changes in salt consumption levels, by evaluating the 24 h urinary sodium excretion. this study is a consortium-initiated, randomised, simple-blinded, controlled trial designed to assess the effectiveness of a salt reduction program versus generic healthy lifestyle program in the lisbon metropolitan area.


Eligibility criteria:
inclusion criteria: * adults between the ages of 20 and 70. * subjects with or without hypertension, not medicated or medicated with medication and diet stabilized for at least 3 weeks. * responsible for the purchase and confection of their meals. * available to comply with study protocol and sign informed consent. exclusion criteria: * pregnant, breastfeeding or planning to become pregnant within the study period. * subjects with current or previous cardiovascular disease (ischemic cardiovascular disease, angina stable or unstable; myocardial infarction, stroke or symptomatic peripheral arteriosclerosis). * subjects with liver or kidney diseases or cancer. * subjects with history of drug, alcohol or other substances abuse, or other factors limiting their ability to cooperate during the study. * subjects with special dietary needs. * health condition that prevents compliance with study requirements.
comparison between the analgesic effectiveness of virtual reality and topical anesthesia: a clinical study

Conditions: Pain

Summary: a split-mouth, controlled trial aimed to clinically compare and evaluate the effectiveness of virtual reality versus topical anesthesia gel prior to administration of dental anesthesia injection in reducing the perceived pain and anxiety level in adult patients and to find out their preferred procedure. heart rate before and after the end of the procedure will be identified, pain intensity of the injection will be identified using a scale, and finally patients' preference will be identified using a questionnaire.

steps of the experiment step i: before the administration of the local anesthesia injection, heart rate will be measured for the patients using an fda approved pulse oximeter (santa medical sm-165 finger pulse oximeter). findings will be recorded. step ii: at the first appointment, patients will be randomly allocated to receive the injection of the local anesthesia either with topical anesthetic gel or with virtual reality in one side of the jaw. step iii: immediately after dental anesthesia injection procedure, the patient will be asked to rate the level of perceived pain, using wong-baker faces pain rating scale (wbfps). step iv: after the administration of the local anesthesia injection, heart rate will be measured for the patients an fda approved pulse oximeter (santa medical sm-165 finger pulse oximeter). findings will be recorded. step v: in the next appointment, the other technique (virtual reality or topical anesthetic gel) will be used on the contralateral side for the same patients. so each patient will receive local anesthesia injection twice, one with topical anesthetic gel and one else with vr in the contralateral side. step vi: after completion of both procedures, each patient will be asked to state his/her preference for the delivery system of future injections to be recorded.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) class i, aged between 18 and 65, both male and female, who required bilateral local anesthetic injections in the premolar teeth in the upper jaw. * participants are in good general health, take no medications, and have no contraindications to the use of local anesthetic. * the ability to understand oral and written instructions, and the ability to use the vr controller. exclusion criteria: * patients who need intravenous sedation cannot participate in the study. * if a patient requires only single visit/ treatment or if he/she cannot attend the other visit.

Keywords: pain perception virtual reality
spinal mobilization and pnf comparison on pain, disability in patients with cervical radiculopathy

Conditions: Cervical Radiculopathy

Summary: as in this modern era of digitalization; mobile phones, touch pads and computers devices use is increasing, neck pain that radiates into upper limb is also becoming common due to such devices long term use in bad postures or positions for more workload. the resulted findings could significantly contribute to the refinement of rehabilitation interventions, offering a more holistic and tailored approach for addressing cervical radiculopathy sensory and motor symptoms, ultimately improving individuals daily living activities and life quality. it will be helpful for physiotherapists to find evidence about comparison of mulligan's spinal mobilization along with arm movement with proprioceptive neuromuscular facilitation technique on pain, disability and range of motion in patients with cervical radiculopathy. it will be beneficial for patients also to improve pain, activities of daily living and working tasks in a comfortable position.

cervical radiculopathy is a clinical situation in which reflex, motor, and sensory alterations e.g. radicular pain, paresthesia, or numbness might be present and might be increased by neck bad postures and movements. due to sustained forward head and neck posture and repetitive movements, cervical pain and numbness is becoming common in office, bank and online workers. the cervical radiculopathy new cases report yearly is almost 107.3 per 1 lac for men and 63.5 per 1 lac for women. it is essential to find new efficient methods of cervical radiculopathy physical therapy management. males and females of age 21-50 years old added in this study. screening tests will include upper limb tension tests (ultt), spurling (compression) test and distraction test. subjects randomly assigned into two groups by lottery method. experimental group (n=19) received mulligan's spinal mobilization with arm movements (smwams) and proprioceptive neuromuscular facilitation (pnf) contract-relax technique and control group (n=19) received proprioceptive neuromuscular facilitation (pnf) contract-relax technique and standard physical therapy protocol including passive stretching exercises (3 sets of 10 repetitions) and isometric strengthening exercises (2 sets of 10 repetitions). outcome measures included numeric pain rating scale (nprs) for pain, neck disability index (ndi) for functional disability and goniometer for range of motion (rom). data analyzed by statistical package for social sciences (spss 26) software.

Eligibility criteria:
inclusion criteria: * both males, females of 21 years to 50 years old * patients already diagnosed by orthopedicians * patients with positive screening (upper limb tension, spurling \& distraction) tests exclusion criteria: * history of trauma, fracture and previous surgery * any pathological condition, spinal instability and tumor * vbi (vertebral-basillar insufficiency) and cervical instability/spondylolisthesis

Keywords: cervical radiculopathy pain range of motion distraction proprioceptive neuromuscular facilitation
efficacy of symbicort pmdi administered once daily in children and adolescents during 12 weeks - sprout

Conditions: Asthma

Summary: the purpose of this study is to compare symbicort with budesonide alone for the treatment of asthma in children aged 6 to 15 years


Eligibility criteria:
inclusion criteria: * at least 6 and maximally 15 years of age * diagnosis of asthma and baseline lung function tests as determined by the protocol * has required and received treatment with inhaled corticosteroids within the timeframe and doses specified in the protocol exclusion criteria: * severe asthma * has required treatment with any non-inhaled corticosteroids within previous 4 weeks, has sensitivity to drugs specified in the protocol or requires treatment with beta-blockers

Keywords: asthma children adolescents symbicort budesonide/ formoterol budesonide
motion immune magnetic resonance imaging (mri)

Conditions: Parkinson's Disease

Summary: the purpose of this study is to evaluate our recently developed mri reconstruction strategy for producing artifact-free neuro and abdominal mri data. the new reconstruction strategies, including 1) rekam and 2) muse, are capable of effectively removing motion-related artifacts resulting from global and local motion during neuro and free-breathing abdominal mri scans, without modifying the mri pulse sequences and protocols that are currently used in clinical scans. the study team aims to recruit 60 subjects across multiple challenge patient populations: 10 healthy young adults (age 20-30) and 10 healthy older adults (aged 50-70) for abdominal mri, as well as 20 tremor dominant pd patients and 20 children (age 4-8) for brain mri scans. there are no known risks in taking mris and a unique code will be assigned to each participant to protect their phi.


Eligibility criteria:
inclusion criteria: 1. subject's age is within one of the following age ranges (4-8, 20-30, or 50-70 years old); 2. male or female; 3. healthy volunteer or diagnosed with pd ; and 4. devoid of the following exclusion criteria. exclusion criteria: 1. claustrophobia or other mri contraindications (including pregnancy); 2. diagnosis for dementia (alzheimer's, lewy body, or vascular); 3. symptomatic psychotic disorders; 4. depression with psychotic symptoms; 5. other psychotic or schizophrenic disorders; 6. recent neuroleptic treatment; 7. history of cardiovascular disease; 8. history of stroke or transient ischemic attack; 9. cancer (other than skin cancer) within the last three years; 10. hospitalization for neurological/psychiatric condition; 11. significant handicaps (e.g., visual or hearing loss, mental retardation) that would interfere with neuropsychological testing or the ability to follow study procedures; or 12. any other factor that in the investigators' judgment may affect patient safety or compliance.

Keywords: mri
switching to faricimab in neovascular age-related macular degeneration resistant to both aflibercept and ranibizumab

Conditions: Neovascular Age-related Macular Degeneration

Summary: the goal of this retrospective single-center chart review is to establish the response rate, efficacy and safety of a single dose of intravitreal faricimab injection in real-world patients with aflibercept- and ranibizumab-resistant neovascular age-related macular degeneration.


Eligibility criteria:
inclusion criteria * presence of neovascular age-related macular degeneration (amd) in the study eye * previous treatment with minimum 6 consecutive, monthly aflibercept (eylea®) injections in the study eye without optimal treatment response, defined as persisting intraretinal fluid or subretinal fluid or both on optical coherence tomography scans * subsequently, a sequential switch to ranibizumab (lucentis®), with minimum 1 injection, also without optimal response * finally, a sequential treatment switch from ranibizumab to faricimab. exclusion criteria * neovascular conditions other than amd (e.g., choroidal neovascularisation due to other causes) or co-existence of other retinal disease in the study eye * significant optical media opacities that would result in poor imaging quality on oct scans in the study eye * intraocular surgery in the study eye 3 months before or within 1 month after the treatment switch
psil201 long-term follow-up study: psilocybin or niacin / major depressive disorder

Conditions: Major Depressive Disorder

Summary: this is a phase 2 double-blind, long-term observational follow-up study of participants from study psil201. participants providing informed consent will be enrolled into this study and will complete web surveys and telephone interviews conducted by one central site at the following time intervals: months 2, 3, 4, 5 and 6 (± 7 days for each assessment) and months 8, 10, 12, 14, 16, 18, 20, 22 and 24 (± 14 days for each assessment).


Eligibility criteria:
inclusion criteria: * enrollment and intervention with the investigational drug in study psil201 exclusion criteria: * inability or unwillingness to complete study procedures, including regular completion of web surveys and telephone interviews with study personnel
adapting alcohol behavioral couple therapy for service members in post-deployment

Conditions: Alcohol Abuse

Summary: the specific aims of the abct_military project are as follows: 1) to modify the existing, alcohol behavioral couple therapy (abct) model to treat service members in the reconstitution (post deployment, reintegration, or separation) stage of service, and develop optional psychoeducation modules to address relevant co-morbid problems and challenges in this population in a weekly, 15 session, stand-alone outpatient format. 2) to test feasibility and preliminary efficacy of the study intervention protocol in a successive cohort design for one cohort of 8 couples and one cohort of 22 couples, with iterative manual revision.

the study staff will screen potential participants over the phone, and arrange baseline (bl) research interviews for appropriate couples. the couple will meet with the program interviewer for approximately 2 hours. after the bl interview, couples will be scheduled to attend therapy sessions. couples will complete brief within treatment self-report assessments. couples will complete a post treatment follow up interview four months after session 1.

Eligibility criteria:
inclusion criteria: * age 18 and older; * married (or separated with efforts to reconcile) or in a committed relationship (cohabiting, or in an exclusive dating relationship), or significant other (so) (first, second or third degree relative (including step relative or in-law) or close trusted friend not active in same military branch. the service member only must meet the following inclusion criteria: * served or serving in the u.s. military, * current alcohol use disorder diagnosis, or drink at high risk levels as defined by niaaa (2010) exclusion criteria: * either individual is not fluent in the english language. exclusion criteria for the service member only: * unstabilized psychotic disorder in past six months exclusion criteria for both members of the couple if so is spouse/romantic partner: * either partner is fearful of participating in couple therapy or either partner suffered severe physical abuse from partner when perpetrator not intoxicated, in past year

Keywords: veterans cognitive therapy couple therapy