Kornimate/medical-research-clean huggingface dataset:
exercise in genetic cardiovascular conditions

Conditions: Hypertrophic Cardiomyopathy; Long QT Syndrome

Summary: the goal is to determine how lifestyle and exercise impact the well-being of individuals with hypertrophic cardiomyopathy (hcm) and long qt syndrome (lqts). ancillary study aim: to understand how the coronavirus epidemic is impacting psychological health and quality of life in the live population

yale is the central site for this multicenter study. patients with hcm and lqts will be recruited via high-volume hcm and lqts sites, patient-groups, and websites. information about exercise participation will be acquired via interview and online instruments at enrollment and every six months for three years. quality of life questionnaires will be filled out at enrollment and at the end of the study. participants will receive a fitbit (pedometer) and will wear it initially for two weeks and then one week every three months. the fitbit is used for assessment of exercise level only. clinical records will be obtained from treating physicians. participants will also be asked to call the central site if they experience syncope, appropriate icd (implantable cardioverter defibrillator) shock, or resuscitated arrest. information regarding the patient's activity at the time of event will then be obtained by phone interview. follow-up clinical records will be obtained as indicated to corroborate endpoints. the ancillary study is optional. this will include all of the baseline questionnaires,as well as selected questions from the epi-pandemic impacts inventory.

Eligibility criteria:
inclusion criteria: * individuals with hypertrophic cardiomyopathy or long qt syndrome exclusion criteria: * individuals with hypertrophic cardiomyopathy with systolic or diastolic heart failure which precludes vigorous exercise will not be enrolled (nyha iii/iv)

Keywords: hypertrophic cardiomyopathy (hcm) long qt syndrome (lqts)
effects of low dose buprenorphine on recovery after hip or knee arthroplasty

Conditions: Pain; Osteoarthritis

Summary: buprenorphine is a highly lipophilic thebaine derivative that appears to have high affinity for mu-, kappa-, and delta-opioid receptors and low affinity for opioid receptors like 1 -receptors. it acts as a partial agonist at the mu-opioid and as a partial agonist/antagonist at the kappa-opioid, and as an antagonist at the delta opioid receptors. buprenorphine has up to two-fold duration of action and it is approximately 30-fold more potent when compared to morphine. pain is a common problem in patients coming to joint arthroplastic surgery. buprenorphine low dose patches are recommended for treatment of moderate pain for example osteoarthritis pain. it is known that well treated pain even preoperatively may prevent prolonged postsurgical pain. in the present study the effects of low dose buprenorphine on postoperative pain and recovery were assessed.


Eligibility criteria:
inclusion criteria: * no pregnancy/lactation, reliable contraception before menopause * elective knee or hip arthroplasty surgery * bmi (=body mass index) 18-35 kg/m2 * obtained informed consent exclusion criteria: * buprenorphine medication * allergy to study drugs• ikä \ 75 years * bmi \ 35 kg/m2 * weight below 50 kg * other contraindication for the study drug

Keywords: pain arthroplasty buprenorphine
cognitive-behavioural treatment of chronic back pain

Conditions: Back Pain

Summary: the purpose of the study: * to compare two cognitive-behavioral treatments

128 patients suffering from chronic back pain were randomly assigned to either wait list control, cognitive behavioral treatment or cognitive behavioral treatment and biofeedback. measures were conducted 6 months before treatment (wait list control) immediately before and after treatment and at 6-months follow-up. 25 weekly 1-hr sessions of individualized outpatient cognitive behavioral treatment of chronic back pain treatment elements: cognitive treatment: identification, evaluation and correction of dysfunctional beliefs about themselves and pain by cognitive restructuring, problem-solving training and coping skills training behavioural treatment: increasing activity levels (sports, social activities, work), reducing medication intake and unnecessary health care utilization relaxation training: progressive muscle relaxation, biofeedback.

Eligibility criteria:
inclusion criteria: * back pain since 6 months exclusion criteria: * patients with psychosis, borderline psychopathy, drug dependence i.e. alcohol

Keywords: cognitive-behavioral therapy back pain low back pain biofeedback randomized controlled study emg biofeedback
18f-fdg pet/ct in diagnostic patients of disorder of consciousness

Conditions: Persistent Vegetative State

Summary: clinical examinations are difficult to discriminate between vegetative state and minimally conscious state. the diagnostic and prognostic usefulness of neuroimaging methods has not been established in a clinical setting. we will do a forward study of pet imaging in disorders of consciousness patients, and validate with clinical assessments with the coma recovery scale-revised(crs-r).

every patient need to be conducted the pet/ct scanning two times.the first time is resting state.the second time is stimulated state by watching a vedio.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of disorder of consciousness exclusion criteria: -
modulating oscillations and working memory in patients with subdural electrodes

Conditions: Working Memory; Epilepsy

Summary: purpose: to investigate whether rhythmic direct electrical stimulation (des) causes entrainment of endogenous neural oscillatory activity and whether such activity improve cognition. participants: drug-resistant epilepsy patients undergoing epilepsy surgery cortical mapping with continuous electrocorticography (ecog) with intracranial electrodes. procedures (methods): rhythmic electrical stimulation will be delivered via intracranial electrodes during routine extra-operative cortical mapping. long-term ecog, pre-stimulation ecog, peri-stimulation ecog, and post-stimulation ecog data will be analyzed to assess for entrainment of neural oscillations.

the aim of this study is to characterize the entrainment of endogenous neural oscillatory activity using direct electrical stimulation (des) of the brain and understand the effects on cognition. in this study, the investigators will apply rhythmic des to patients who are undergoing routine des for cortical mapping as a part of their epilepsy surgery evaluation with the aim of entraining cortical neural oscillations at specific frequencies relevant to cognitive processing and neuropsychiatric disease. the investigators hypothesize that rhythmic des within a naturally occurring oscillatory frequency will cause entrainment at that frequency (e.g. 10hz rhythmic des will entrain a 10 hz alpha oscillation). also, the investigators posit that rhythmic des at the theta (5hz), alpha(10hz), and gamma (50hz) frequencies will cause enhancement of neural oscillations in the gamma band. the study follows a within-participant crossover design. participants will perform one of the tasks described below and each task consists of multiple trials of varying difficulty. stimulation will be applied concurrently through electrodes implanted for clinical determination of seizure focus. equal number of stimulation and sham trials will be pseudo-randomly interleaved to get a balanced design (balanced across trial difficulty and trial type). the investigators will apply electrical stimulation in the form of pulse trains. the applied electrical stimulation intensity, duration and frequency follow the parameters used for clinical assessments of language and seizure focus and fall below the clinically approved limits. the investigators will measure participants performance on a simple working memory task during the above-described cortical electrical stimulation protocol. alternately, participants can perform a face recognition task.

Eligibility criteria:
inclusion criteria: 1. history of medically intractable epilepsy 2. capable of giving informed consent 3. aged 18 - 80 years, either sex exclusion criteria: 1. past or current history of other neurological illnesses including ischemic stroke, intracerebral hemorrhage, brain neoplasm. 2. major systemic illness 3. severe cognitive impairment defined as mini-mental state examination of less than 20 4. severe psychiatric illness 5. excessive use of alcohol or other substances

Keywords: facial recognition
description of physical activity effect on neuromuscular fatigue of older people

Conditions: Aging; Fatigue

Summary: there is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance with advancing age. physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. the aim of this project is to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.

with advancing age, there is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance and increases the likelihood that older people will lose their independence. physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. indeed, recent data support the idea that it is fitness level, not age that explains physiological responses to exercise. however, although there are data about how quickly cardiovascular and neuromuscular functions decline throughout life, less is known on the extent physical activity can help mitigate the loss of these functions. the aim of this project is therefore to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.

Eligibility criteria:
inclusion criteria: * aged 18 to 35 for the young group, between 65 and 80 for the old group and over 80 for the very old group. * signed consent for the study obtained * subject affiliated or entitled to a social security scheme exclusion criteria: * pathology or surgical intervention causing a locomotor disorder * neurological, cardiovascular or psychological pathology * participants will be excluded if resting or exercise ecg responses show any abnormality, or if resting heart rate (hr) \> 100 bmp, resting blood pressure \> 144 (systolic) / 95 (diastolic) mmhg, pulmonary and or cardiac disease that could affect the health of the participant (arrhythmias and stroke) * mini-mental state examination score \ 80 years old) * significant change in the amount of physical practice over the last 5 years.

Keywords: cardiovascular function neuromuscular function v02max
postencephalitic symptoms after tick borne encephalitis

Conditions: Central European Encephalitis

Summary: the purpose of this study is to assess clinical outcome in patients with tick borne encephalitis.


Eligibility criteria:
inclusion criteria: * serologically proved tick borne encephalitis in patients \> 15 years exclusion criteria: * pregnancy

Keywords: tick borne encephalitis clinical outcome postencephalitic symptoms
neuroglove ptsd study

Conditions: PTSD; Post Traumatic Stress Disorder

Summary: this is a prospective, home-based, interventional clinical study in which 6 subjects will be enrolled. six (6) subjects who suffer from post-traumatic stress disorder will receive treatment using the neuroglove.

this is a prospective, home-based, interventional clinical study in which 6 subjects will be enrolled. six (6) subjects who suffer from post-traumatic stress disorder will receive treatment using the neuroglove. there will be a single cohort in the study consisting of the subjects with ptsd who will receive treatment with neuroglove. the trial is intended to evaluate the impact of the device use on active ptsd symptoms and subject sense of well-being.

Eligibility criteria:
inclusion criteria: * able to and willing to provide informed consent. legally authorized representatives (lars) will not be allowed to consent on behalf of the subject. * men and women ≥18 and \<85 years of age. * carry an active diagnosis of ptsd. * suffer from ptsd symptoms that impact subject's daily activities and quality of life. exclusion criteria: * physical limitations of the upper extremity (e.g., fracture, joint deformity, severe spasticity/contracture, wounds, skin breakdown, lymphedema, etc.) * subject lacks the ability to comprehend or following instructions, or for any reason, in the opinion of the investigator, would be unlikely or unable to comply with study protocol requirements. * currently participating in another interventional clinical trial. (observational clinical trial participation is allowed for study enrollment.)

Keywords: ptsd post traumatic stress disorder
path clinical data research network (cdrn) study of healthy lifestyles and health care

Conditions: Weight

Summary: the purpose of the path clinical data research network (cdrn) study of healthy lifestyles, body weight and health care is to use clinical data from electronic health records (ehr) and patient reported outcomes (pro) to answer questions of clinical importance to patients, providers, and other stakeholders.

the primary objective is to create the path clinical data research network (cdrn) study of healthy lifestyles, body weight and health care, which will allow the conduct of patient-centered observational studies on weight across the multiple institutions of the path network. creating the path clinical data research network (cdrn) study of healthy lifestyles, body weight and health care will involve: 1. recruiting patients with longitudinal weight data in the ehr to participate in the path clinical data research network (cdrn) study of healthy lifestyles, body weight and health care 2. administering surveys to the path clinical data research network (cdrn) study of healthy lifestyles, body weight and health care approximately every 6 months to collect patient reported outcomes (pros) 3. collecting individual patient health record data into the path clinical data research network (cdrn) study of healthy lifestyles, body weight and health care database 4. identifying potential participants for future research studies. 5. tracking whether the patient participant has biospecimens in a path site biorepository and prepare for possible sharing of biospecimens in future studies. the secondary objectives are to use the path clinical data research network (cdrn) study of healthy lifestyles, body weight and health care to answer patient-centered research questions including: (1) how do survey response rates, sample demographics and survey responses differ by recruitment technique? (2) what are patients' weight management strategies? how much are health care providers contributing to their weight management approaches? do these relationships vary by weight status, region, age, sex, or race; (3) what are patients' reasons for seeking bariatric surgery and expectations in terms of weight change?; (4) among patients seeking bariatric surgery, what proportion with high risk for sleep apnea by survey responses have been evaluated for or diagnosed with this health problem? (5) how does physical activity vary with patients co-morbidity status?

Eligibility criteria:
inclusion criteria: * age in years (\>= 18 years), at the time of the initial data query * height - at least 1 at any time; can be outside 5-year cohort time window * weight : two encounters each with weight within the 5-year cohort time window exclusion criteria: * deceased * not proficient in english * already enrolled in the path clinical data research network (cdrn) study of healthy lifestyles, body weight and health care in another path institution
safety and efficacy of gw685698x an inhaled corticosteroid once daily and twice daily for the treatment of asthma

Conditions: Asthma

Summary: the purpose of this study is to compare once and twice daily gw685698 in asthma


Eligibility criteria:
key inclusion criteria: * clinical diagnosis of asthma * reversibility ≥ 12% and ≥200mls reversibility of fev1 within approximately 30-minutes following 2 to 4 puffs of albuterol * fev1 between 40-85% predicted * currently on short acting beta2 agonist therapy key exclusion criteria: * history of life threatening asthma * respiratory infection or oropharyngeal candidiasis * asthma exacerbation * uncontrolled disease or clinical abnormality * allergies * taking another investigational medications or other prohibited medications
gabapentin to treat itch in patients with liver disease

Conditions: Liver Disease; Cholestasis; Cirrhosis; Pruritus; Itching

Summary: in this study, the effect of the medication gabapentin to treat itching secondary to liver disease is being studied. there are some funds to cover travel expenses for patients who are not from new york (ny). gabapentin is approved to treat seizures in human beings. in this study, patients with liver disease who meet inclusion criteria are admitted to the research hospital of the new york presbyterian hospital to record scratching behavior by the use of a machine designed for that purpose. blood work will be obtained. after completion of recording, patients are assigned by chance to receive active medication or placebo (a capsule that does not contain active medication). the patients will come to the outpatient office of the research hospital 2 weeks into the study for an interview and blood work. after 4 weeks, patients are readmitted to the hospital to record scratching behavior. after data are collected, the code is broken, if patient had been on inactive drug, active drug will be supplied as per protocol for 4 weeks. blood work will be obtained. if patient had been randomized to active medication, the study will provide one week supply of drug. after that, the referring physician, with whom the study was previously discussed, could prescribe the medication as it is available.

double-blind, randomized, placebo-controlled study of gabapentin for the pruritus of cholestasis. duration: 4 weeks. some travel funds available for patients from out of the ny area for all the visits. hospitalization at baseline and after 4 weeks of treatment. one outpatient department visit at week 2. all patients have to be referred by their physician, who will receive a summary of the results at the end of the patient's study participation. if patients are randomized to active drug and respond to it with decrease in pruritus, a one week supply of medication is given. the referring physician could prescribe the drug for long term use. if the patient is randomized to placebo they can be treated with active medication provided by the study for 4 weeks, at end of which, the drug could be prescribed by referring physician if the patient responds to the drug with decrease in the pruritus.

Eligibility criteria:
inclusion criteria include: * patients from ages 18 to 80 with chronic pruritus secondary to liver disease patients must have: * a normal chest x- ray during the previous year * normal thyroid function tests (treated thyroid dysfunction is acceptable) * controlled diabetes, if diabetes mellitus is present * negative fecal occult blood within the previous year exclusion criteria include: * history of hepatic encephalopathy * decompensated liver disease as suggested by ascites and history of variceal bleeding * malignancy * inability to practice contraception * pregnancy * creatinine \> 1.7 mg/dl * hemoglobin \< 10mg/dl * s/p liver transplantation * hiv infection

Keywords: itching pruritus cholestasis liver disease hepatitis cirrhosis
preoperative mindfulness: minimally invasive hysterectomy

Conditions: Pain, Postoperative

Summary: this is a randomized control trial investigating the effects of a preoperative mindfulness intervention on postoperative pain, quality of recovery and stress scores in women undergoing minimally invasive hysterectomy. the mindfulness intervention will be delivered via the application headspace™. the primary outcome will be pain scores measured on postoperative day one. secondary outcomes will include quality of recovery scores and perceived stress scores measured on postoperative days 1 and 7, amount of opioid consumed, and dose response between number of sessions and/or numbers of minutes of meditation performed on pain and quality of recovery scores. the study team hypothesizes that mindfulness practiced in the form of meditation delivered via an internet application will lead to reduced pain scores on postoperative day 1.


Eligibility criteria:
inclusion criteria: * undergo minimally invasive hysterectomy * fluency in english * access to a device capable of running the headspace application (smart phone or computer) exclusion criteria: * minors * inability to access headspace app * inability to complete surveys in english
effect of effect of a medicated topical therapy , petrolatum, and no treatment on nocturnal cough

Conditions: Respiratory Tract Diseases

Summary: this study seeks to subjectively evaluate whether a single application of vicks® vaporub® (vvr) ointment or a control ointment (petrolatum) will be superior to no treatment for control of nocturnal cough and congestion due to upper respiratory tract infection (uri) as rated by both parents and children.


Eligibility criteria:
inclusion criteria: * cough and congestion attributed to upper respiratory tract infection exclusion criteria: * children with signs or symptoms of more serious or treatable disease * presence of itchy, watery eyes or frequent sneezing * tachypnea (respiratory rate \>95%ile) or labored breathing * symptoms for 8 or more days * history of asthma in the past 2 years, chronic lung disease, or seizure disorder * history of an allergic reaction to camphor, menthol, eucalyptus, petrolatum, cedarleaf oil, nutmeg oil, thymol, turpentine oil, over-the-counter medication containing vvr components

Keywords: cough symptoms cold symptoms congestion children uri alternative cough symptom treatment
erector spina plane (esp) block in pediatric patients

Conditions: Acute Postoperative Pain

Summary: in this study, we aimed to evaluate the erector spina plane (esp) block method that we used in our clinic with ultrasonography in pediatric cases between 1 month and 2 years of age who underwent laparotomy.

36 patients who will undergo laparotomy between the ages of 1 month and 2 years in asa ( american society of anesthesiologists) i-ii class will be included in the study. patients will be divided into 2 groups. intraoperative erector spina plane block will be applied to the 1st group (group e) and intraoperative local anesthetic infiltration will be applied to the 2nd group (group l). postoperative pain will be evaluated with the flacc (face, legs, activity, crying, consolation) scale.

Eligibility criteria:
inclusion criteria: * 1 month and 2 years of age * asa (american society of anesthesiologists) i-ii class * patients who underwent nephrectomy, pyeloplasty, adrenal tumor excision with unilateral paramedian incision exclusion criteria: * patients who underwent laparotomy with a midline incision * local infection at the injection site, * anatomical anomalies * allergies to local anesthetics, * coagulopathy, * liver, kidney failure patients

Keywords: erector spina plane block pediatric patient