Kornimate/medical-research-clean huggingface dataset:
an explorative study to develop a predictive model based on avascular exposed root surface area for root coverage

Conditions: Gingival Recession

Summary: the aim of this study was to evaluate the reliability of the avascular root surface area as a prognostic identification criterion for gingival recessions and to compare the predictive value of the miller classification and avascular root surface area (aersa) calculation on the final root coverage outcomes.


Eligibility criteria:
inclusion criteria: * presence of isolated miller i, ii or iii recession, (miller 1985a) * presence of identifiable cementoenamel junction (cej); presence of a step ≤ 2mm at cej level and/or the presence of a root abrasion, but with an identifiable cej, * full-mouth plaque score and full-mouth bleeding score of \< 15% (four sites/tooth), * no occlusal interferences; * non-smokers exclusion criteria: * tooth with a prosthetic restoration involving cej, * patients with a history of periodontitis or abscess formation, * presence of systemic disease or taking medications known to interfere with periodontal tissue health * pregnant or nursing patients
clinical evaluation of truevision system: lri and capsulorhexis templates

Conditions: Subjects Undergoing Cataract Surgery and Insertion of IOL

Summary: to evaluate the ability of the truevision 3d visualization and guidance system for microsurgery to provide the ophthalmic surgeon appropriate alignment, orientation and sizing information during cataract or refractive lens exchange surgery. device images, safety results and surgeon questionnaire will demonstrate that the truevision system provides clear images to assist surgeons during lri or capsulorhexis procedures.


Eligibility criteria:
inclusion criteria: * healthy eye with no previous ocular surgery * natural lens for which phacoemulsification extraction and posterior iol implantation is planned * clear intraocular media other than cataract * potential visual acuity 20/30 or better * able to comply with preop and postop examination procedures * signed and dated informed consent exclusion criteria: * keratometric astigmatism \> 2.5 diopters * corneal pathology potentially affecting topography including corneal degeneration * irregular astigmatism * macular degeneration or any other macular disease which reduces potential acuity * previous corneal surgery (including lasik, radial keratotomy, penetrating keratoplasty, etc) * use of systemic or ocular medications that affects vision * acute or chronic systemic or ocular disease or illness that would increase risk or confound study results * use of flomax or any other medication which negatively impacts surgical outcomes * history of ocular trauma or ocular surgery

Keywords: limbal relaxing incision lri capsulorhexis surgical guidance 3d visualization
achilles tendon elongation and gait pattern after rupture.

Conditions: Achilles Tendon Rupture

Summary: the objective of this study is to determine if achilles tendon elongation and gait pattern differ between patients treated using an individualized treatment algorithm and patients treated as usual (two control groups; patients treated operatively and non-operatively). the individualized treatment algorithm is based on ultrasonographic status of tendon overlap and copenhagen achilles length measure (1). patients are allocated for operative treatment if there the tendon overlap is less than 25 % or the tendon is elongated with 7% or more compared to the healthy, contralateral achilles tendon.


Eligibility criteria:
inclusion criteria: * appointment in the outpatients department within 4 days of injury. * total achilles tendon rupture. * initial treatment with split cast with the ankle in maximal plantar flexion must be started within 24 hours of injury. * the patient must be expected to be able to attend rehabilitation and postexamination. * the patient must be able to speak and understand danish. * the patient must be able to give informed consent. exclusion criteria: * rupture of the achilles tendon either at the insertion on the calcaneus or at musculotendinous junction of the triceps surae. * previous rupture of the achilles tendon in any of the two legs. * treated with fluoroquinolones or corticosteroids within the last 6 months. * in medical treatment of diabetes. * suffers from rheumatic disease. * other conditions prior to the injury resulting in reduced function of any of the two legs. * contra-indication for surgery: severe arthrosclerosis with no palpable pulse in the foot, broken skin in the achilles region of the injured leg. * inability to lie in prone position on the operating table. * terminal illness or severe medical illness: american society of anaesthesiologists physical status classification score higher than or equal to 3.
effectiveness of single dose oral dexamethasone versus multidose prednisolone for treatment of acute exacerbations of asthma among children attending the emergency department of children hospital, islamabad

Conditions: Asthma in Children

Summary: in this study i'll compare the effectiveness of two drugs used in acute exacerbation of asthma by their sideffects, complaince and improvement in the pram score. the better one would be adapted in our clinical practice.


Eligibility criteria:
inclusion criteria: * i.ages 2 to 12years ii. previous history of asthma as diagnosed by a physician. iii. presentation with acute exacerbation of asthma with symptoms of cough, wheeze, dyspnoea and oxygen saturation of less than 95% and with pram score of more than or equal to 6 exclusion criteria: * i.critical or life-threatening asthma i.e. patient with silent chest, cyanosis, drowsy, unable to verbalize, marked tachycardia and respiratory distress. ii.known tb exposure iii.fever more than 39. 5°c iv.use of corticosteroids in previous 4 weeks v.significant co-morbid disease: lung, cardiac, immune, liver, endocrine, neurological or psychiatric
quantitative sensory testing and pet/ct scanning in assessment of surgical outcome for lumbar disc herniation

Conditions: Lumbar Disc Herniation; Radiculopathy Lumbar

Summary: patients with lumbar disc herniation suffer from pain and morbidity. surgical intervention can be a quick and effective relief, however some individuals experience less favorable outcome. this study tries to investigate and test the differences in pain perception and pain modulation between individuals. using pet/ct scans the investigators try to visualize pain perception and -modulation in the cns. this is subsequently correlated with a battery of pain tests and the surgical outcome of disc herniation surgery.


Eligibility criteria:
inclusion criteria: * informed consent * clinical and radiological indication for ldh surgery, assessed by an experienced spinal surgeon * age 40-65 years * able to comply with regulations regarding medicine consumption (stated below) exclusion criteria: * history of previous spine surgery * general contra-indication for spine surgery * greatly reduced kidney function * diagnosis of psychiatric disorder * current malignant disease * history of radiation therapy * current chemotherapy * history of spinal fracture * hematologic disease * current pregnancy or breast-feeding * chronic, generalized connective tissue disorders or chronic, non-specific pain disorders (fibromyalgia, whiplash (wad i-v), etc.)

Keywords: pet/ct
increase tolerance for exercise and raise activity through connectedness trial

Conditions: Cystic Fibrosis

Summary: in this research study the investigators want to learn more about whether using a fitness tracker and accelerometer helps patients with cystic fibrosis exercise more regularly, and in turn whether it increases exercise tolerance over the period of one year.

the aim of this study is to evaluate whether the use of a fitbit device and an exercise prescription is associated with increased daily activity and in turn increased exercise tolerance in young adult patients with cystic fibrosis (cf). the investigators hypothesize that use of the fitbit and an exercise prescription will be associated with increased exercise tolerance compared to standard counseling and an exercise prescription alone. for patients with cf, young adulthood and adolescence is a significant time of vulnerability. in addition to normal behavioral challenges of adolescence and young adulthood (seeking independence/autonomy while also choosing rebellion), those with cf are often dealing with significant disease progression. therefore, working in new innovative ways to improve adherence to regimens that improve lung function such as exercise are needed to continue to support patients during this vulnerable time. studies of patients with cystic fibrosis have shown that regular exercise training can decrease rate of lung function decline, potentially improve lung function, and improve aerobic capacity. however, many patients do not include regular exercise in their daily routine. successful strategies to improve adherence include providing patient specific guidelines for an appropriate exercise program, supporting participation and providing positive feedback. overall, exercise is a crucial diagnostic and therapeutic modality for patients with cystic fibrosis, although awareness somewhat limited. the adult cf program at boston children's and brigham \& women's hospital established an inpatient and outpatient exercise program as part of a quality improvement effort. patients are prescribed an individualized exercise program or exercise prescription based on their assessment during a sub-maximal effort. this program has been successful but given the rigors of daily life (e.g. school, work, family obligations), adherence is a concern with resources limiting more rigorous feedback to maintain this essential life activity.

Eligibility criteria:
inclusion criteria: 1. a diagnosis of cystic fibrosis 2. age 18 and over 3. must be able to complete at least level 1 of the baseline exercise fitness test 4. must not have required iv antibiotics for a cf exacerbation within 30 days of starting the program exclusion criteria: 1. pregnancy at enrollment 2. a history of cf exacerbation requiring iv antibiotics within last month 3. use of a fitness tracker or similar product within 6 months of enrollment

Keywords: cystic fibrosis exercise fitbit
early identification of suspected deep tissue injury (sdti)

Conditions: Pressure Ulcer; Bed Sore

Summary: the purpose of this study is to further clarify existing research on the early identification and documentation of suspected deep tissue injury (sdti). basic principles of physiology along with prior research suggests that sdti has quantifiable amounts of heat (or lack thereof) relative to surrounding tissue that will exhibit characteristic thermal signatures (temperature). these signatures will be measured and quantitatively recorded using long-wave infrared thermography (lwit) to not only identify sdti, but to also learn more about their pathophysiological evolution. additionally, the lwit physiological data will be cross-compared to the gold standard of visual assessment and other current standards of wound evaluation.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * can tolerate position changes ≥ 10 minutes * non-pregnant exclusion criteria: * therapies/treatments cannot be safely suspended to for an imaging session * non-english speaking
transcutaneous electric muscle stimulation (tems) in septic patients

Conditions: Septic Shock

Summary: a growing number of critically ill patients survive intensive care to be discharged from hospital. however, critical illness and prolonged bedrest are associated with muscle wasting with subsequent implications for recovery of normal physical function. thus, one year after discharge, survivors of septic shock have reported prolonged and severe impairment of physical function. early interventions employed in the icu to counteract loss of muscle mass may potentially improve physical outcome and reduce the overall burden of critical illness. as a potential supplement to physical therapy, transcutaneous electric muscle stimulation (tems) is a non-invasive method directed at maintaining skeletal muscle function through artificially induced contractions that are independent of patient efforts. tems has previously proven effective at preventing loss of muscle mass and force in a number of non-icu patient groups, but has only been assessed sparsely in an icu population where both immobilisation and systemic inflammation are present. therefore, the aim of the present study was to assess the effect of early tems on muscle volume in patients admitted to the intensive care unit with septic shock. the investigators hypothesized that this intervention would preserve muscle volume during septic shock.

to ensures baseline comparability, eliminates many of the inter-individual confounding factors often present in icu patients and enhances statistical strength we designed a study where we included a well-defined group of patients with septic shock in a single-legged exercise design, using the contralateral leg as the (paired) control and used a two-channel stimulation approach with 3-d evaluation of muscle volume changes based on ct scans. after randomization of the quadriceps muscles tems is applied on the intervention side for 7 consecutive days, 60 minutes per day. all patients undergoes ct scans of both thighs before and immediately after the 7-day treatment period. the quadriceps muscle is then manually delineated on the transverse ct slices, and muscle volumes are calculated after 3-d reconstruction.

Eligibility criteria:
inclusion criteria: * patients with septic shock admitted to the icu of rigshospitalet * written informed consent from patient or proxy exclusion criteria: * diabetes * a focus of infection in or trauma to the lower extremities * a predicted icu stay of less than seven days * severe respiratory or circulatory instability that precluded transportation of the patient to the ct scanner * patients receiving hihg dose corticosteroids (equivalent to methylprednisolone 1mg/kg/day or more) * pregnancy * severe psychiatric disorder * \> 72 hours since the diagnosis of septic shock was established * \> 7 days immobilisation prior to time of inclusion * patient receiving neuromuscular blocking agents * pre-existing neuromuscular disease * acute compression/affection of central or peripheral nerves relevant to the lower extremities * bmi \> 30

Keywords: muscular atrophy recovery of function rehabilitation intensive care unit
safety and efficacy of sofosbuvir/velpatasvir/voxilaprevir fixed-dose combination for 12 weeks in adults who participated in a prior gilead-sponsored hcv treatment study

Conditions: Hepatitis C Virus Infection

Summary: the primary objectives of this study are to determine the efficacy, safety, and tolerability of treatment with sofosbuvir/velpatasvir/voxilaprevir (sof/vel/vox) fixed-dose combination (fdc) for 12 weeks in participants with chronic hepatitis c virus (hcv) infection with or without cirrhosis, who did not achieve sustained viral response (svr) after receiving prior treatment in a gilead-sponsored hcv treatment study of direct-acting antiviral (daa)-containing regimens.


Eligibility criteria:
key inclusion criteria: * chronically hcv-infected males and non-pregnant/non-lactating females aged 18 years or older who did not achieve sustained virologic response (svr) in a prior gilead-sponsored hcv treatment study note: other protocol defined inclusion/exclusion criteria may apply.
effects of cyproterone compound-spironolactone, metformin and pioglitazone on inflammatory markers in pcos

Conditions: Polycystic Ovary Syndrome

Summary: the aim of this study is to evaluate the effects of three-month course of treatment modalities (cyproterone compound-spironolactone, metformin and pioglitazone) in patients with polycystic ovary syndrome (pcos) on markers of inflammation \[serum complement, homocysteine and high sensitive c-reactive protein (hs-crp)\] levels.

polycystic ovary syndrome (pcos) is estimated to affect up to10% of women of reproductive age, making it one of the most common endocrine disorders in this population. pcos is associated with a broad range of adverse sequel, including hypertension, dyslipidemia, insulin resistance, hyperandrogenaemia, gestational and type 2 diabetes,which ultimately increase the cardiovascular morbidity in these patients. also pcos is increasingly recognized as a component of the metabolic syndrome. management depends on symptoms or the source of androgen excess. several treatment options are available, which allows for an individualized approach. spironolactone is the safest potent available antiandrogen. it is effective in lowering the hirsutism score by approximately one third, although considerable individual variations exist. other antiandrogens used to treat hirsutism and hirsutism equivalents include cyproterone acetate that has weak antiglucocorticoid effects. metformin and thiazolidinediones, are promising adjuncts for treating pcos. although both of them increase insulin sensitivity, but their mechanism of action differ. serum complement, homocysteine and c-reactive protein (crp) levels have been reported to be linked with insulin resistance. the investigators want to measure serum complement, homocysteine and hs-crp levels in patients with pcos before and after three-month course of treatment with cyproterone compound-spironolactone (cc-s), metformin (m) and pioglitazone (p).

Eligibility criteria:
inclusion criteria: * age 18-35 years * diagnosis of polycystic ovary syndrome (pcos) according to rotterdam criteria 2003 (two out of three required): 1. oligomenorrhea or anovulation 2. clinical and/or biochemical signs of hyperandrogenism 3. polycystic ovaries (by ultrasound) exclusion criteria: * smoking * pregnancy * diabetes mellitus * renal failure (serum creatinine \>1.5) * congenital adrenal hyperplasia * hyper or hypothyroidism * sex hormone therapy or antiandrogen therapy during the last three months * unexplained serum alanin aminotransferase (alt) elevation more than 2.5 times above normal range * any systemic or febrile illnesses * use of glucocorticoid or anti-inflammatory drugs during the last three months * androgen secreting tumor * malignancy

Keywords: inflammation complement system proteins homocysteine c-reactive protein cyproterone ethinyl estradiol androgen antagonists metformin thiazolidinediones pioglitazone
framing and decision making in neonatology

Conditions: Prematurity; Framing; Perinatal Decision Making

Summary: the purpose of this study is to study how people make decisions regarding delivery room management for infants born extremely premature when survival and long term outcomes are uncertain. the hypothesis is that the way in which information is presented will impact decisions. there have been many advances in neonatal care in recent decades. however, the investigators do not know if these children will grow up to be healthy or if they will have problems with mental retardation, behavior or physical handicaps. in these circumstances, where the medical profession cannot predict what sort of life a child will have, parents have a choice of having intensive care started or of allowing the baby to die naturally. the age most often cited by physicians at which this care is optional and under parental discretion is 23 weeks gestation. the purpose of this study was to ask people, recruited through the world wide web, what they would want for the doctor to do in the case of a hypothetical 23 week premature delivery in order to evaluate the decision process and the presence of autonomous choice. this study had two parts. the first part, presented outcome information in 2 different ways -either as survival and lack of severe disability or as mortality and presence of severe disability. the results of the first part have been published (message framing and perinatal decisions, pediatrics, 2008). the second part, investigated whether the way in which the way in which delivery room management options were presented- either as agreeing with a course of action or opting out- impacted resuscitation decisions. this part was administered as a separate survey to a different sample of participants at a later date. the remainder of the questionnaires asked demographic and opinion questions as a means to assess variables that may influence how people respond to the information they receive.


Eligibility criteria:
inclusion criteria: \>18 yo exclusion criteria: \<18 yo

Keywords: decision making premature infant informed consent prematurity framing negotiation model
correlation between patient perception and findings on clinical examination

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: this is a multi-center, prospective, non-interventional study that aims to evaluate in daily clinical practice, the possible corelation between patient perception of the ability to perform morning activities and physician evaluation; patients with copd, grade c and d.

correlation between patient perception of the ability to perform morning activities and findings on clinical examination in copd patients

Eligibility criteria:
inclusion criteria: * diagnosis of copd, grade c and d according to gold guidelines revised 2011 * current or past smokers, of at least 10 pack years * receive any inhaled combination therapy for copd (inhaled corticosteroid / long acting β2-agonist bronchodilator) initiated for at least one month before entering in the study exclusion criteria: * history of exacerbation of copd symptoms within the last month before visit 1, inclusive; history of asthma or allergic rhinitis; history of lung carcinoma or any other respiratory condition that may limit the airflow circulation * inability to understand study procedures and inability/refuse to complete cdlm questionnaires and/or record the values showed on the pedometer screen

Keywords: cdlm visual scale - physician evaluation copd gold group c and d