Kornimate/medical-research-clean huggingface dataset:
timely recovery after subclinical heart failure

Conditions: Heart Failure; Diastolic Dysfunction

Summary: the goal of this randomized controlled trial is to assess the effectiveness of ace inhibitors versus standard care) in reversing asymptomatic heart failure (hf stage-b) and/or diastolic dysfunction during a two-year open-label treatment period for formerly preeclamptic women on: 1. reversibility of structural and functional myocardial impairment in asymptomatic hf towards healthy values; 2. the progression from asymptomatic to symptomatic hf (symptoms scored based on the nyha criteria); 3. cardiovascular performance (volume- and pressure load), cardio metabolic risk factors (glucose metabolism, lipid status, kidney function) and quality of life (questionnaires); 4. novel biomarkers and relevant microrna's indicative for hypertrophy, fibrosis inflammation and ischemia. eligible subjects will be counselled and upon informed consent randomized for either medication group (n=65) or care as usual group (n=65). after a complete cardiovascular assessment, medication will be initiated open-labeled (perindopril 2 mg or no medication). thereafter, standard medical check-ups (blood pressure, ecg, kidney function, transthoracic cardiac ultrasound, endothelial function, quality of life questionnaires, medical history taking, blood and urine banking) will be performed every six months for two years. researchers will compare ace inhibitor (perindopril 2 mg) and care as usual (i.e. no medication) to investigate whether ace inhibitor allows timely recovery after subclinical heart failure.


Eligibility criteria:
inclusion criteria: * all women who visit maastricht univeristy medical center+ for cardiovascular screening with subclinical/asymptomatic heart failure (hf stage-b) and/or diastolic dysfunction; * aged 18 years and older; * premenopausal women with a history of preeclamptic pregnancy and premenopausal women with a history of normal pregnancy; * between 0.5 and 30 years postpartum; exclusion criteria: * intention to pursue pregnancy within 2 years; * already using antihypertensive medication; * suffering diabetes mellitus, kidney failure (gfr\&lt;60 ml/min/1.73m2), pre-existent auto-immune disease and/or liver insufficiency; * breastfeeding during participation; * previous angio-edema

Keywords: pre-eclampsia hypertension heart failure treatment
an immunity persistence study of live attenuated varicella vaccine

Conditions: Varicella

Summary: this an open phase ⅳ clinical trial of live attenuated varicella vaccines manufactured by sinovac (dalian) vaccine technology co., ltd .the purpose of this study is to evaluate the immunity persistence of live attenuated varicella vaccine at 5 and 8 years after primary immunization with live attenuated varicella vaccine.

this study is an open phase ⅳ clinical trial in subjects who enrolled in the clinical trial and included in the immunogenicity subgroup pps set from august to september 2016 .the experimental vaccine and placebo (freeze dired dilution) were manufactured by sinovac (dalian) vaccine technology co., ltd.a total of 703 subjects will be enrolled including 349 subjects in experimental group and 354 subjects in control group .and 3.0-3.5ml of venous blood was collected from all subjects at 5 and 8 years after primary immunization, and the serum was separated for varicella antibody detection. the window period of blood collection was six months.

Eligibility criteria:
inclusion criteria: * subjects in pps immunogenicity subgroup of phase ⅲ clinical trial of protective effect of varicella vaccine; * the subject and/or guardian can understand and voluntarily sign the informed consent form; * proven legal identity. exclusion criteria: * history of chickenpox or shingles; * history of varicella vaccination since phase ⅲ clinical trial; * autoimmune disease or immunodeficiency / immunosuppression; * history of immunosuppressive therapy since phase ⅲ clinical trial; * according to the investigator's judgment, the subject has any other factors that are not suitable for participating in the clinical trial.
prematurity-related ventilatory control: role in respiratory outcomes

Conditions: Infant, Premature

Summary: the objective of this common multicenter protocol is to test the hypothesis that algorithmic tools using clinical neonatal intensive care unit (nicu) cardiorespiratory monitoring data can detect ventilatory control instability and predict chronic and acute respiratory consequences of ventilatory control instability and autonomic dysregulation.


Eligibility criteria:
inclusion criteria: * neonatal intensive care unit patient on cardiorespiratory monitor which has been configured to collect data to store for this study * \< 29 wks gestational age * \< 1 wk chronological exclusion criteria: * unlikely to survive or decision not to pursue full care * major congenital or chromosomal anomaly
a clinical trial of dental device cemented with polymethyl methacrylate (pmma) bone cement

Conditions: Edentulism

Summary: conventional bridge and dental implants have been playing a significant role in replacing missing tooth/teeth. but they come with shortcomings. hence, to explore the possibility of addressing such shortcomings, a clinical trial study of a new dental device made of zirconia is intended to be studied to see if it could serve as an additional option for fixed prosthodontics. an approach to explore possibilities for cheaper and faster procedure with regards to the treatment of tooth/teeth loss.

objectives: to determine whether the use of a new dental device made of zirconia cemented with polymethyl methacrylate (pmma) bone cement could be an additional option for a faster treatment for missing tooth/teeth with fixed/removable prosthodontics. methodology: after a cone beam computed tomography (cbct) scan and clinical evaluation, 48 samples of zirconia dental device will be cemented with pmma bone cement in edentulous area on randomized population. immediate loading (0-15 days) with single crown and multiple unit bridge made of zirconia will be cemented using luting cement as fixed restoration. radiographic evaluation and clinical examination will be conducted every three (3) months for one year. expected outcome: a new dental device made of zirconia could be an additional option for the treatment of edentulism, which could be completed within 0-15 days with minimal risk.

Eligibility criteria:
inclusion criteria: * adult patients (18 years old and above) who agrees for the treatment * single/multiple missing tooth/teeth (edentulism) * maxillary/mandibular bone density of more than 350 hounsfield unit (hu) * edentulous region with minimum of 2mm bone width and 5mm of bone height * well controlled diabetes and hypertension exclusion criteria: * severe/critical medical conditions * adults above 80 years old
adjuvant radiotherapy in patients with early endometrial cancer

Conditions: Endometrial Cancer; Pathology; Radiotherapy

Summary: to compare the effect of vaginal brachytherapy as adjuvant treatment after operation when compared to pelvic external beam radiotherapy in patients with early endometrial cancer based on moderate risk molecules classification.

after being informed the study and potential risk，all patients giving written informed consent will be undergo a 1-week screening period determine eligibility for study entry. at week 0, patients who meet the eligibility will be randomized in a 1:1 ratio to vaginal brachytherapy or pelvic external beam radiotherapy. after treatment, patients were followed up regularly.

Eligibility criteria:
inclusion criteria: 1. endometrial adenocarcinoma is confirmed by pathology, and the molecular types were microsatellite instability type and low copy type; 2. stage ia and grade 3 or stage ib (figo 2009), without substantial lymph-vascular space invasion; 3. surgery must have included a hysterectomy and bilateral adnexectomy. pelvic lymph node sampling and para-aortic lymph node sampling are optional; 4. ecog score is 0-2; 5. the interval time between surgery and radiotherapy is no more than 8 weeks; 6. the routine blood examination was normal; 7. compliance is good and informed consent is voluntarily signed. exclusion criteria: 1. the patients receive chemotherapy; 2. history of previous malignant disease; 3. previous diagnosis of crohn's disease or ulcerative colitis.
sequential method determination of oxycodone for thoracoscope surgery median effective dose of acute pain treatment

Conditions: Oxycodone; Thoracoscopic Lobectomy; Acute Postoperative Pain

Summary: the goal of this clinical trial is to measure the median effective dose of oxycodone for the treatment of acute pain after thoracoscopic lobectomy. this clinical trial was divided into two groups based on age, group i (age \< 65 years old) and group ii (age ≥65 years old). we used the sequential allocation designed by dixon. the initial oxycodone dose was set to 0.1 mg/kg.a satisfactory or an unsatisfactory analgesic response of the previous patient determined, respectively, the relative 10% decrease or increase in the dose of oxycodone the next patient received in the same group. the patient before the first crossover point was included as the first case for ed50 estimation in each group.the study was conducted until 7 crossover points were collected


Eligibility criteria:
inclusion criteria: 1. the first unilateral thoracoscopic lobectomy was performed under general anesthesia 2. age 18- 80 years old 3. american society of anesthesiologists (asa) physical status i-iii 4. sign the informed consent of the patients exclusion criteria: 1. moderate to severe obesity (i.e., bmi \> 30kg/m2) 2. allergic or hypersensitive reaction to oxycodon 3. a history of chronic pain 4. patients with significant heart, pulmonary, liver or renal disease
influence of serum sodium levels on bone metabolism and turnover in hospitalized patients

Conditions: Hyponatremia

Summary: in this study, the possible role of serum sodium concentration and its changes on bone markers in hospitalized, hyponatremic patients is determined. therefore, it is investigated whether in hospitalized, hyponatremic patients the level of carboxy-terminal collagen crosslinks (ctx) is modified by changes in plasma sodium concentration, independently from the aetiology of hyponatremia.


Eligibility criteria:
inclusion criteria: * adult hospitalized patients with non-hypertonic hyponatremia: serum sodium \< 130 mmol/l, serum osmolality \< 300 milliosmol /kg * age 18 to 99-year-old * informed consent as documented by signature exclusion criteria: * severe symptomatic hyponatremia in need of intensive care treatment * hypertonic hyponatremia with serum osmolality \> 300 mosm/kg * end of life care (palliative treatment) * end stage kidney disease (dialysis) * acute liver failure * wernicke encephalopathy * hepatic encephalopathy during last 2 months * hepato-renal syndrome * any bone disease requiring treatment in the last three years * history of fragility fractures * pre-menopausal women * hypogonadism (diagnosed before hospitalization) * hyperthyroidism * steroid therapy

Keywords: electrolyte disorder bone metabolism sodium levels
severe acute respiratory infection - preparedness (covid-19 and influenza)

Conditions: Pneumonia, Viral

Summary: severe acute respiratory infection (sari) is defined by the world health organization (who) as acute respiratory infection with a history of fever ≥38°c and cough for less than 10 days duration that requires hospital admission. sari-prep is a multi-center consortium funded by the cdc foundation being assembled with the goal of providing the infrastructure to rapidly collect prospective data on clinical risks and outcomes, hospital-level stress, and biologic specimens that will aid in the rapid development of diagnostic and treatment approaches. a current example of a form of sari to be targeted by sari-prep is covid-19 the acute respiratory infectious disease caused by sars-cov-2 infection. covid-19 has a broad set of manifestations and severity with a subset of affected patients developing severe disease leading to respiratory failure and other forms of organ dysfunction. as with many outbreaks of novel viral pathogens causing sari there was no efficacious therapeutic intervention at the beginning of the covid-19 pandemic. furthermore, while there is emerging knowledge of clinical risks for severe covid-19, there remains a paucity of information about the viral dynamics and host responses that might indicate a patient is at high risk for poor outcomes. the covid-19 pandemic will be the initial target of the sari-prep consortium with the overall goal of developing a multi-institutional collaborative network of acute care hospitals that will rapidly enroll, sample, and follow patients admitted with severe covid-19 and to develop research protocols to rapidly determine demographic, clinical, host molecular, virologic, and institutional correlates of outcome. overall, the information gained from this effort will help to rapidly inform and improve clinical management of epidemic/pandemic sari patients.


Eligibility criteria:
inclusion criteria: * admission to an acute care or intensive care unit with a clinical syndrome of lower respiratory tract infection suspicious for viral sari: * fever * cough * and (radiographic infiltrates by imaging (chest x-ray, ct scan, etc.) or spo2 ≤ 94% on room air or requiring new supplemental oxygen (above baseline if preexisting) or requiring invasive or non-invasive mechanical ventilation). * confirmed viral cause for sari by respiratory viral rt-pcr testing. exclusion criteria: * prisoners or wards of the state * inability to consent or lack of availability of legal surrogate * do not attempt resuscitation/do not intubate status on admission
retinal function in relation to long term changes in the glucose level

Conditions: Diabetes Mellitus

Summary: the purpose of this study is to measure the amplitude and implicit time of electroretinogram (erg), darkadaptation and the calibre of retinal vessels before and after optimized medical treatment of diabetic individuals (a lower blood glucose level) over a period of 12 months. newly diagnosed type 1 and type 2 diabetics as well as dysregulated type 1 and type 2 diabetic individuals will be included. retinal vessel calibre measurements will be used as an estimation of changes in the retinal perfusion.


Eligibility criteria:
inclusion criteria: * dysregulated type 1 diabetic individuals and newly diagnosed type 1 diabetics. age \>17 \< 60 years exclusion criteria: * test individuals with significant cataract, prior surgery to the eye, diabetic retinopathy, other serious eye disease, hypertension, other serious systemic disease.
the impact of the previous exposure to covid-19 virus infection on the outcome of icsi cycles

Conditions: COVID-19; IVF

Summary: whilst the global covid-19 pandemic is still evolving and there are many unknowns about the long-term effects of the virus on fertility and pregnancy, we found ourselves in need to offer some evidence-based guidance, that's why we decided to go for this study, to evaluate the relation of the covid-19 and the outcome of ivf/icsi cycles. we found that there is no clear evidence that the previous exposure to covid-19 virus infection can affect the outcome of icsi cycles significantly.

this is an observational study, for 122 icsi cycles conducted in al- baraka fertility hospital, manama, bahrain, and al-manea hospital, ksa between august 2020 and may 2021, and it was approved by the ethical committees. we compared the outcome results of those patients who got recovered from previous exposure to covid-19 (study group) with results of non-infected comparable patients (control group) after comparison of the basal characteristics in both groups, and we got assured that there is no significant difference regarding the demographic criteria between both groups, we found that there is no significant difference regarding the duration of stimulation, the total dose of stimulation, number of oocytes retrieved, number of metaphase 2 oocytes (mii), number of grade1-2 embryos, number of transferred embryos, day of embryo transfer and fertilization rate. although the fertilization rate was higher in covid-19 free patients (52% vs. 50.6%), however, this difference is not statistically significant. in the same way, the pregnancy rate was also higher in the covid-19 negative group (45.1% vs. 36.4%); however this difference was not statistically significant.

Eligibility criteria:
* inclusion criteria were women who got recovered from covid-19 based upon their history with positive test results confirmed via beaware bahrain phone application and tawakkalna saudi phone application; with age below 38 yrs., body mass index (bmi) below 30 kg/m2, who underwent antagonist protocol for ivf * exclusion criteria were chromosomal and genetic disorders, age\> 38 years, bmi \> 30, abnormal ultrasonogram of the uterine cavity (acquired or congenital), those who underwent long agonist protocol, and those cases with severe male factor, and abnormal embryos not suitable for transfer, we excluded also patients with those who got vaccinated against covid-19 and those with current infection.
combined motor and cognitive training for older adults with motoric cognitive risk syndrome (cmc-training)

Conditions: Disability Physical; Disabilities Mental; Age Problem

Summary: to investigate the effects of a combined motor-cognitive intervention on the improvement of motor as well as cognitive function in community residents.

cognitive training uses systematically designed tasks that are difficulty-adaptive for cognitive domains such as attention, memory, and logical reasoning to improve individual cognitive functioning. internet-based adaptive multi-cognitive domain cognitive training is conducted 3 times per week for 30 minutes each time, and includes tasks such as delayed memory, paired memory, and inverse numerical breadth. the exercise intervention was based on the m-mobile multicomponent exercise program, in which older adults were instructed to complete exercise training at home at least three days per week. in all intervention groups, balance, sitting test and walking speed were assessed according to the simple physical performance battery (sppb), and according to their scores, they were given exercise training, including flexibility, balance, aerobic training and resistance training.

Eligibility criteria:
inclusion criteria: * age 60-80 years; ≥ 9 years of education; cognitive impairment: mmse score 22-26; slow gait:total walking time \>4 seconds and ≤8 seconds in a 4-meter walk test; agreed to participate in the study and signed an informed consent form. exclusion criteria: * dementia/suspected dementia; suffering from diseases that affect cognitive function, such as cerebrovascular disease, parkinson's syndrome, etc.; taking medications related to cognitive improvement and psychiatric disorders, etc.; recent heart attack, severe cerebrovascular disease, psychiatric disorders, etc.; other inability to persist in completing exercise cognitive interventions, such as suffering from severe musculoskeletal disorders; participating in another clinical trial at the same time； participation in an exercise and/or cognitive intervention in the past 6 months; inability to complete content in studies such as neuropsychological scale assessments.

Keywords: motoric cognitive risk cognitive training exercise training
high working memory load to reduce internet gaming disorder (igd) cravings

Conditions: Internet Gaming Disorder

Summary: to test whether high working memory load can effectively reduce the craving for igd.

this project is to use 1-back task and 3-back task to reduce the craving of internet gamers. to test whether high working memory load can effectively reduce the craving for igd. this project will be conducted in beijing, china, based on a large sample of internet gamers.

Eligibility criteria:
inclusion criteria: * the scores of the 9 items of the diagnostic and statistical manual of mental disorders, fifth edition(dsm-5) recommended diagnosis for internet gaming disorder ≥ 5. * engagement in popular internet games (e.g. arena of valor, league of legends and player unknown's battle grounds) for over 20 hours per week for a minimum of 12 months. * the scores of theyoung-internet addiction test(y-iat) ≥ 50 exclusion criteria: * current or history of use of illegal substances and gambling; * current or history of psychiatric or neurological illness; * current use of psychotropic medications.
efficacy of pilocarpine 1% in presbyopia

Conditions: Presbyopia; Pseudophakia

Summary: in this before-after interventional study on patients with presbyopia after cataract surgery, uncorrected distance vision and corrected distance visual acuity are measured and recorded by snellen chart. corrected near visual acuity from a distance of 40 cm is measured by the standard near vision chart (rosenbaum near vision card). twenty minutes after the administration of pilocarpine 1%, the corrected near and far visual acuity is measured again. also, the relationship between the difference in average near visual acuity after the administration of 1% pilocarpine in pseudophakic people is measured with iris color and pupil size.

after selecting the study cases, the pupil size in both photopic and scotopic conditions and iris color(based on simionescu's classification) will be recorded. uncorrected distance visual acuity(ucdva) will be measured by snellen chart. then the appropriate glasses will be placed according to the person's refraction and the corrected distance visual acuity(bcdva) will be measured. without changing the fitted glasses, corrected near visual acuity(bcnva) is measured from a distance of 40 cm by the standard near vision chart (rosenbaum near vision card). after this stage, one drop of pilocarpine 1% is prescribed in the patient's eye and 20 minutes later, the corrected near and far visual acuity is measured again. thirty minutes and 8 hours after the administration of pilocarpine drop, the side effects of the drug, including headache, eye pain, eye redness, eye irritation, tearing, and blurred vision at night, are checked.

Eligibility criteria:
inclusion criteria: * informed consent to participate in the study * previous uncomplicated cartaract surgery and pciol insertion * bcdva eqaul to or more than 8/10 * less than 1.5 diopter cylindrical refractive error * spherical refractive error between -0.5_+1.5 * no history of previous eye disease * not using drugs that interact with pilocarpine exclusion criteria: * occurrence of any drug-related complications * unable to follow up the patient after prescribing the drug

Keywords: pilocarpine presbyopia pseudophakia