Kornimate/medical-research-clean huggingface dataset:
nerve sparing radical hysterectomy vs radical hysterectomy: safety and clinical efficacy

Conditions: Cervical Cancer

Summary: cervical cancer in young patients increased significantly in recent years, and early surgical treatment for patients with 5 years of survival rate is as high as 90%, but the traditional extensive hysterectomy (rh) caused by intraoperative pelvic autonomic nerve may damage the bladder and rectum and the incidence of complications such as sexual dysfunction is nearly 25% to 80%, thus seriously affect the patient's quality of life.pelvic autonomic nerve preservation system of extensive hysterectomy (nsrh) can decrease the complications of above, but at home and abroad mainly adopts pulling the urine tube time, determination methods of residual urine volume, bladder function are studied in only a few scholars urine flow mechanics method is applied to carry on objective appraisal limited cases of postoperative bladder function, and the anorectal function damage ，we can use the anorectal dynamics to get objective index of anorectal function .overall research lack of large sample research of dynamic system. no objective index to evaluate the anorectal function in the early stage of the study, we have conducted about uterine ligament, sacral ligaments and nerve distribution of the bladder cervix vaginal ligament of experimental research, provide the neural anatomy basis for nsrh operation, and based on research for innovative operation scheme is put forward.proposed on the basis of the above research, this study adopt the internationally used - urine flow mechanics, the method for evaluating the bladder function of nsrh, rh, two kinds of the injured function of bladder surgery patients before and after operation of comparative study, the change of dynamic assessment before and after surgery in patients with bladder function,and the anorectal function dameage and than provide the basis for further treatment.


Eligibility criteria:
inclusion criteria: * cervical cancer figo(2009) ia2,ib1,ib2,iia1,iia2 exclusion criteria: * cervical cancer figo(2009) \> iib * patients received radiotherapy before opration * the patient refused to sign a consent form.

Keywords: cervical cancer nsrh rh urine flow mechanics anorectal dynamics
efficacy and safety of levocetirizine 8 weeks prior and after the onset of the grass pollen season in subjects with sar

Conditions: Rhinitis, Allergic, Seasonal

Summary: efficacy and safety of levocetirizine 8 weeks prior and after the onset of the grass pollen season in subjects with sar


Eligibility criteria:
inclusion criteria: * male or female subjects ≥ 12 years * 2 year history of seasonal allergic rhinitis * documented hypersensitivity to local seasonal allergens (grass pollen) * documented pollen-induced asthma * without acute ongoing exacerbation of asthma or allergic rhinitis * no continuous ongoing treatment for rhinitis or asthma exclusion criteria: * non-allergic rhinitis and anatomic abnormalities disturbing the analysis of nasal capacity * symptomatic rhinitis or asthma due to tree pollens * currently treated by specific grass pollen immunotherapy * suffering from non-allergic asthma * chronic use of inhaled steroids and/or long acting β2 agonists; and/or corticosteroid dependent asthma * atopic dermatitis or urticaria requiring an antihistamine treatment or the administration of oral or topical corticosteroids * contraindication for salbutamol use

Keywords: levocetirizine dihydrochloride xyzal tablets
post-operative monitoring of gastric cancer

Conditions: Gastric Cancer

Summary: this study is to determine the performance of non-invasive new multi-target biomarkers in the post-operative monitoring of gastric cancer.

this study aims to develop and validate a new non-invasive detection method for postoperative monitoring of gastric cancer in the blood. blood will also be collected at various time points post-operatively. we will determine whether these new biomarkers can be used as prognostic biomarkers to predict tumor recurrence and metastasis. we will also determine whether these new biomarkers detect tumor recurrence and metastasis earlier than methods currently used in the clinic such as imaging and tumor biomarkers ca19-9, cea, and ca72-4. this study is a prospective and multi-center study.

Eligibility criteria:
inclusion criteria: 1. subject age over 18. 2. subject has stomach discomfort, and seek medical attention at the gastric surgery department of our center. 3. subject has or will have gastroscopy and/or pathological examination results at this center. 4. subject must be able to fully understand the informed consent form and be able to personally sign it. exclusion criteria: 1. subject has serious heart, liver, kidney dysfunction, or mental illness. 2. subject diagnosed previously with any kind of malignant tumor. 3. subject is known to be infected with hiv or other related diseases (considering interference from the use of immune drugs). 4. subject is receiving targeted drugs, immunosuppressants, immunomodulators, and biological therapies. 5. researchers believe that subject is not suitable for enrollment. 6. subject can not supply sufficient sample to complete this experiment.
covid-19 3rd dose vaccine in transplant patients

Conditions: Covid19

Summary: the purpose of this study is to investigate the efficient vaccine type as a booster dose for coronavirus disease of 2019 (covid-19) in solid organ transplant recipients.


Eligibility criteria:
inclusion criteria: * patients 18 years of age and older * patients who had received a solid organ (kidney, liver, lung, heart, and pancreas) transplant patient from living or deceased donors. * patients with active graft with at least one immunosuppressive medication * completed two doses of bnt162b2 vaccination at least 28 days ago exclusion criteria: * patient with non-active graft * any significant side effect with previous covid-19 vaccination * within 28 days of bnt162b2 vaccine completion * already received more than and equal to three doses of covid-19 vaccination * previously received covid-19 vaccine other than bnt162b2 vaccine * previously received monoclonal antibody treatment that are specifically directed against the spike protein for severe acute respiratory syndrome (sars) coronavirus 2 (cov)-2 such as mab, bamlanivimab, etesevimab, casirivimab, imdevimab, sotrovimab and/or any combination. * thrombocytopenia (if less than 50,000 per microliter 30 days prior vaccination) * history of capillary leak syndrome * adults unable to consent * individuals who are not yet adults (younger than 18 year old) * vulnerable patients (prisoners) * pregnant women

Keywords: transplant patients
evaluation of decision capacity of icu patients under sedatives. a prospective observational multicenter study.

Conditions: Intensive Care Unit Patient; Mechanical Ventilation; Sedatives; Decision-making Capacity; Confusion

Summary: this prospective observational multicenter study is intended to investigate the impact of sedatives on the decision capacity of intensive care units patients.

medicine has recently turned from paternalism to patient-centered decisions giving them back autonomy to determine their own treatments and end-of-life directives. main prerequisite is patient's competence to fully understand information given from medical staff, integrate it and resituate comprehensive willing. informed decision-making necessitates patient's ability to appropriately communicate and interact with its environment. intensive care unit (icu) patients are often intubated -rendering oral communication impossible- and get sedated with various medications (hypnotics and opioids). despite an apparently appropriate communication, some of them are confused. confusion is regularly under diagnosed in icu settings and necessitates specific tools to be detected, such as cam-icu (confusion assessment method in icu). while not confused, a patient might lack decision-making capacity, meaning that despite obvious communication, more elaborated cognitive function remains uncertain and often inappropriate. decision-making capacity can be evaluated with dedicated scores such as the johns hopkins adapted cognitive examination (ace). this score has recently been formally translated into french. the influence of sedatives on decision-making capacity remains unknown to date. this prospective observational multicentre study is intended to investigate the impact of sedatives on the decision-making capacity of icu patients. furthermore, each sub-score of the ace (orientation, language, registration, attention and calculation, and recall) will be investigated according to sedatives types. patients' decision-making capacity will be clinically assessed by physician, resident and nurse in charge, blindly of ace result.

Eligibility criteria:
inclusion criteria: * mechanically ventilated patient (intubation or tracheotomy) * not delirious (negative cam icu) * calm and alert (rass -1 to +1) since at least 12 hours and less than 72 hours * receiving sedatives and/or analgesics and/or medications interfering with neurological functions * adult patients with social security coverage exclusion criteria: * brain injured patients (traumatic brain injury, ischemic or hemorrhagic stroke, sub-arachnoid hemorrhage, intra-parenchymal bleeding, hypoxic post cardiac arrest) * known cognitive disorders (mmse \< 20) * neurodegenerative disease * pregnant woman * protocol refusal by the patient or closest next-of-kin

Keywords: intensive care unit patient mechanical ventilation sedatives decision-making capacity confusion
circadian as a prognostic factor for radiation response in cervical cancer

Conditions: Cervical Cancer; Radiotherapy Side Effect

Summary: the study was a randomized clinical trial (rct) or clinical trial comparing the results of radiation treatment of 2 treatment groups, i.e. subject groups irradiated in the morning and in the afternoon, to check melatonin levels in cervical cancer patients. since it is known that the function of melatonin is as an antiproliferation substance or hormone, induces apoptosis, inhibits invasion and metastasis.


Eligibility criteria:
inclusion criteria: * cervical cancer patients stage iib-iiib (figo) * no previous treatment * histopathologic examination results of squamous cell carcinoma (scc) * kps \> 70 with levels of hb \> 10 g%, exclusion criteria: * distant metastasis and locally spread to the adjacent healthy tissue (urinary bladder or rectum).

Keywords: radiosensitivity circadian rhythm
physical activity level in psychosis patients

Conditions: Psychosis

Summary: the aim of this study was to examine the effect of physical activity level on social participation, functioning and quality of life in patients with psychosis.

positive and negative symptoms of schizophrenia will be assessed using the positive and negative syndrome scale, depression will be assessed using the calgary depression in schizophrenia scale, medication side effects will be assessed using the glasgow antipsychotic side effect rating scale, physical activity level will be assessed using the international physical activity form, social participation will be assessed using the social participation questionnaire, functioning will be assessed using the brief functioning assessment scale and quality of life will be assessed using the nottingham health profile. the assessments are planned to last 30 minutes for each participant. participants will be assessed only once and will not be reassessed.

Eligibility criteria:
inclusion criteria: * patients diagnosed with schizophrenia and other psychotic disorders according to dsm-v criteria (brief psychosis disorder, schizophreniform disorder, schizoaffective disorder, other disorder with psychosis within the scope of another defined schizophrenia and other disorders with psychosis, other disorders with psychosis within the scope of undefined schizophrenia and other disorders with psychosis), who have had their first episode, who are receiving outpatient treatment * whose duration of illness is longer than 2 years * being between the ages of 18-65 * being literate exclusion criteria: * the participant is in a period of active illness that makes it difficult to conduct research (positive and negative syndrome scale\>70 scale points, calgary depression in schizophrenia scale score \>11 scale points) * comorbid psychiatric illness * the patient has an acute or chronic physical illness that impairs the general medical condition and a disease that will affect cognitive functions (neurological, neoplastic, endocrine and immune disorders, infection, epilepsy or any neurological disease, etc.). * the patient has a physical illness (loss of limbs, paralysis, etc.) that requires additional care and causes significant disability * alcohol and substance use disorder

Keywords: psychosis social participation functioning quality of life physical activity
prediction of response to recruitment maneuvers in patients with acute respiratory failure

Conditions: Acute Respiratory Failure

Summary: the study will explore the possibility to predict potential for recruitment in acute hypoxemic respiratory failure patients by electrical impedance tomography (eit) swisstom bb2 (swisstom, landquart, switzerland) during stepwise increase in positive end-expiratory pressure (peep) followed by recruitment maneuver (rm). it will compare data obtained by eit to those obtained by pressure-volume (p-v) curves on respiratory system mechanics and data on pulmonary gas exchange.

the investigators will monitor lung ventilation by eit during the whole protocol and perform p-v curves and arterial blood gas analysis at every step of the protocol. participants will be sedated and paralyzed, ventilated in volume-controlled with protective ventilation (tidal volume=6-8 ml/kg of predicted body weight and respiratory rate set to obtain normal ph) then the protocol will follow 5 steps each lasting 20 minutes to obtain clinical stability: 1. peep 5 centimeter of water (cmh2o) 2. peep 10 cmh2o 3. recruitment maneuver followed by peep 15 cmh2o 4. peep 10 cmh2o 5. peep 5 cmh2o

Eligibility criteria:
inclusion criteria: * patients with acute hypoxemic respiratory failure defined by recent known clinical insult or worsening of respiratory symptoms and arterial pressure of oxygen to inspired fraction of oxygen ratio (pao2/fio2) ≤300 mmhg * patient on invasive mechanical ventilation * age ≥18 years * written informed consent exclusion criteria: * pregnancy * unstable hemodynamic condition requiring blood transfusion or adjustment of inotropics more often than every hour * fio2 ≥80% or clinical suspicion of pulmonary embolism * pneumothorax * chronic obstructive pulmonary disease (copd) with clinical symptoms of lung emphysema as evidenced by chest radiography or computed tomography or autopeep \> 5 cmh2o * intracranial hypertension * impossibility to correctly position the eit belt (e.g., dressings, chest drainage, etc.) * contraindications to eit (e.g., implantable cardiac defibrillator, pacemaker, instable spinal lesions)
radiofrequency ablation vs. laser ablation of the incompetent small saphenous vein

Conditions: Chronic Venous Insufficiency

Summary: the aim of this study is to perform a randomized, prospective trial comparing the two current methods of treatment for chronic venous insufficiency related to the small saphenous vein (ssv) to evaluate complications and outcomes for each method, and ultimately, to see if one is superior to the other.

chronic venous insufficiency (cvi) is estimated to affect 25 million americans. this condition leads to varicose veins, aching, fatigue, swelling, ulcerations, and bleeding in the lower extremities. the second most common cause is a refluxing or incompetent small saphenous vein (ssv). this condition results in pooling of deoxygenated blood in the lower extremities rather than successful transport of the blood back to the heart and lungs. the historical treatment has been to surgically remove or 'strip' the ssv so that blood is rerouted through the healthier deep veins. a less invasive treatment option, endovenous thermal ablation, has emerged over the last decade and has virtually replaced stripping. this involves advancing a catheter under ultrasound guidance through the ssv and then advancing a laser fiber or radiofrequency probe through the catheter. these devices then produce the energy to destroy the vein as the catheters are slowly pulled back. while both radiofrequency ablation and laser ablation are accepted treatments, neither technology has been definitively proved to have fewer complications or superior results. this is in part because very few practices have the ability to make a head to head comparison between the two technologies and must choose one or the other secondary to financial constraints. the aim of this study is to perform a randomized prospective trial comparing the two modalities so that more definitive information to evaluate complications and outcome can be obtained and then recommendations on which, if either, technology is superior can be made.

Eligibility criteria:
inclusion criteria: * patients with symptomatic chronic venous insufficiency. * patients in whom endovenous thermal ablation is clinically indicated. * have previously undergone at least 6 weeks of conservative treatment with compression stockings (unless they have venous ulcers, recurrent phlebitis, or bleeding varices). * have symptoms secondary to small saphenous vein insufficiency defined as reverse flow in the saphenous vein \>0.5 seconds after calf compression or while standing. exclusion criteria: * have previously undergone surgery, evta, or phlebectomy in that extremity (exclusive of spider vein injections or other cosmetic surface procedures). * have a history of deep venous thrombosis (dvt). * have a history of hypercoaguability disorder. * are pregnant or breastfeeding. * are nonambulatory.

Keywords: chronic venous insufficiency varicose vein small saphenous vein
optimal time to start antiretroviral therapy in hiv-infected adults with cryptococcal meningitis

Conditions: Cryptococcal Meningitis; HIV Infections

Summary: the goal of this randomized clinical trial is to compare early versus standard timing of initiation of antiretroviral therapy (art) with respect to clearance of cryptococcus neoformans from cerebrospinal fluid (csf) among hiv-infected adults with cryptococcal meningitis. the investigators hypothesize that early art mediates more rapid clearance of c. neoformans from csf, as manifested by a greater rate of decrease in c. neoformans colony forming units (cfus) during the first 28 days after initiating antifungal treatment. secondary hypotheses are that recovery of pathogen specific cellular immunity directed at c. neoformans, as manifested by increases in the number and function of c. neoformans-specific peripheral blood mononuclear cells is associated with 1) art and 2) pathogen clearance. in addition, patients randomized to the intervention arm will have more rapid clearance of antigen levels in csf and serum and will have a lower incidence of grade 3 and 4 adverse events.


Eligibility criteria:
inclusion criteria: * hiv 1 infection confirmed by licensed elisa kit and/or detectable viral load. * confirmed cryptococcal meningitis on the current admission by india ink or csf cryptococcal antigen * art naive at the time of enrollment * 21 years old and above * ability and willingness to give written informed consent to participate in the study * able (as assessed by the patient's medical team)to initiate amphotericin b for cryptococcal meningitis * initiated amphotericin b 72 hours or less prior to assessment for enrollment or not on amphotericin b at the time of assessment for enrollment * agrees to obtain outpatient care after discharge within 50 kilometers from princess marina hospital,scottish livingstone hospital and bamalete lutheran hospital exclusion criteria: * recent (within the past 4 weeks) antifungal use * pregnant or breastfeeding * initiated anti-tubercular therapy 2 weeks or less prior to assessment for enrollment. * bacterial meningitis at the time of assessment for enrollment. * recent (within the past 1 month) use of the following:systemic cancer chemotherapy,oral or intravenous corticosteroids or other immunomodulators. * judged by study coordinator to be likely to initiate chemotherapy or any other immunomodulatory therapy prior to the 4 week lp. * imprisoned.

Keywords: hiv-1 africa botswana highly active antiretroviral therapy treatment naive
a long-term observational study evaluating eteplirsen, golodirsen, or casimersen in routine clinical practice

Conditions: Duchenne Muscular Dystrophy

Summary: this is a phase 4, multicenter, prospective, observational study designed to collect both medical history data and prospective data on duchenne muscular dystrophy (dmd) treatment outcomes in participants receiving eteplirsen, golodirsen, and casimersen in routine clinical practice. participants in this study will have been prescribed eteplirsen, golodirsen, or casimersen commercially prior to entry into the study.


Eligibility criteria:
key inclusion criteria: * is willing to provide informed assent or consent (if applicable) and has a parent(s) or legal guardian(s) or is a participant ≥18 years of age who is (are) willing to provide informed consent for the participant to participate in the study and comply with study data collection procedures. * has an established clinical diagnosis of dmd, as documented prior to screening by a genetic report. * receiving, or initiating treatment with, eteplirsen, golodirsen, or casimersen at the time of observational study enrollment. note: participants with a prescription for eteplirsen, golodirsen, or casimersen at enrollment must initiate the exon-skipping therapy within 6 months of the date of enrollment or will no longer be eligible for this study. note: enrollment of eteplirsen participants has been completed, no additional participants will be enrolled. key exclusion criteria: * is currently participating in any dmd interventional study at the time of this study enrollment. * has declined to provide consent for collection of their genetic data. * has a medical condition or confounding circumstances that, in the opinion of the investigator, might compromise: 1. the participant's ability to comply with the protocol-required procedures 2. the participant's wellbeing or safety, and/or 3. the clinical interpretability of the data collected from the participant. other inclusion/exclusion criteria may apply.

Keywords: duchenne muscular dystrophy dmd post-marketing observational phase 4 eteplirsen golodirsen casimersen