Kornimate/medical-research-clean huggingface dataset:
investigating participation patterns among stage iv melanoma patients

Conditions: Stage IV Melanoma

Summary: clinical trials, specifically focused on stage iv melanoma, are crucial in assessing the safety and efficacy of new treatments for this disease. these trials serve as fundamental instruments in determining whether emerging medications outperform standard therapies, providing compelling evidence to support wider implementation. the main goal is to thoroughly scrutinize trial completion rates and voluntary withdrawals among this particular group of patients.


Eligibility criteria:
inclusion criteria: * aged ≥ 18 years old * diagnosis of stage iv melanoma * able to comprehend the investigational nature of the protocol and provide informed consent exclusion criteria: * female patients who are currently pregnant or nursing * has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial. * inability to perform regular electronic reporting

Keywords: stage iv melanoma
hippocampal radiation exposure and memory

Conditions: Arteriovenous Malformation; Schwannoma; Trigeminal Neuralgia

Summary: neurocognitive impairment as a result of gamma knife radiosurgery has not been well studied and is poorly understood. radiosurgery to the base of skull for the treatment of benign and malignant disorders may consequently impair memory function. there is a need to evaluate changes in memory function that may be associated with such exposures. in this pilot study, we will investigate changes in hippocampal-dependent memory function in 10 patients receiving a low srs dose to the hippocampus. we will also investigate such changes in a no-dose control group and a high-dose control group. this study will provide preliminary estimates of variance in memory changes associated with radiation exposure, and will then permit us to design future studies with the appropriate sample size justification.


Eligibility criteria:
inclusion criteria: * patients planned for radiosurgery for benign disorders (groups 1\&2). * patients planned for prophylactic cranial irradiation (group 3) exclusion criteria: * previous cranial radiation * severe psychiatric disorder * severe cognitive or memory impairment (mmse \< 21) * non-english speaking, which will potentially make memory testing difficult and unreliable. * other medical conditions deemed by the pi or associates to make the patient ineligible for protocol procedures * patients on steroid medications. * left hand dominant patients * dose exposure to left hippocampus \>0.5gy and \ 0.5 gy and \< 2gy following baseline memory testing. * benzodiazepine or narcotics given on the day of radiotherapy/radiosurgery prior to completion of the study procedures * previous brain surgery within one year prior to radiosurgery * pregnant women

Keywords: hippocampus memory radiation
pain sensitivity and psychological profile of chronic low back pain patients

Conditions: Low Back Pain

Summary: this study aims to characterize pain sensitivity and psychological profile of clbp patients in comparison with pain free adults, and explore their predictive role on hypnosis outcomes, an effective intervention for pain control.

chronic low back pain (clbp) is a very prevalent condition, associated with high disability and financial costs. pain sensitization and psychological status have been associated with symptom severity and treatment outcomes, but their prognostic value is not yet well established. this is a prospective randomized controlled trial, with an experimental (hypnosis) and one control group (standard care), and 5 assessment points: baseline, post intervention, 1, 3 and 6 months follow-up. participants will be 160 clbp patients and 50 pain free adults, assessed on sociodemographic, clinical, pain, disability, psychophysical (quantitative sensory testing) and psychological variables. this work will contribute to a better knowledge of the mechanisms underlying clbp and of the patient characteristics that can predict treatment outcomes after hypnosis. the findings have the potential to improve patient-targeted treatment approaches.

Eligibility criteria:
inclusion criteria: * persistent or recurrent low back pain lasting over 3 months exclusion criteria: * pain due to other causes (e.g. fibromyalgia, fracture) * back surgery in the previous 6 months or planned in the following 6 months * debilitating organic, psychiatric or neurological conditions (e.g. cancer, schizophrenia, dementia) * disability compensation or litigation related to clbp * unavailability to commit to the hypnosis sessions.
trial of an interactive cd-program on 6 months readmission rate in patients with heart failure

Conditions: Heart Failure

Summary: the purpose of this study is to determine whether extra education of patients with chronic heart failure can reduce 6 months readmission rate to hospital.

the prevalence of heart failure (hf) has increased in the western world and is a major concern due to increasing prevalence and rising health care costs. the prognosis remains poor despite improvement in survival due to treatment with ace-inhibitors and beta-receptor antagonists. hf has a high rate of readmission and hospitalisation. some readmissions are ascribed to patients' lack of compliance, insufficient knowledge about diet, medication and symptoms of heart failure. education of patients has become an important component in order to increase the patients' self-care and compliance. intense education and counselling of patients is recommended in both european and american guidelines for hf. several systematic reviews of studies on strategies for improvement of outcomes of heart failure patients after discharge have been published, but very little emphasis has been put on methodological issues, e.g. methods of education. in most programs the methods and equipment used for education and information have only consisted of verbal and written material; computer-based tools seem to be relatively new. interactive cd-rom programs for hf patients can increase patients' knowledge about heart failure and its treatment. however, no studies have examined the clinical outcome, e.g. rate of readmission. comparison: extra educated patients (interactive cd-rom education) compared to standard educated patients on readmission rate or death during 6 months.

Eligibility criteria:
inclusion criteria: * inpatients treated for heart failure with left ventricular ejection fraction (lvef) \< 40 % at echocardiography or at least two of the criteria pulmonary rates, peripheral oedema, a third heart sound and signs of heart failure at chest x-ray. exclusion criteria: * somatic disease or physical handicap with difficulties to communicate or handle the technical equipment, patients with only little knowledge in swedish, patients with expected problems with compliance due to alcohol/drug abuse or major psychiatric illness, and participation in a trial.

Keywords: heart failure education cd-rom randomization hospitalization readmission death knowledge
bmgim music therapy method in reducing stress in patients with inflammatory bowel disease

Conditions: Bowel Diseases, Inflammatory; Crohn Disease; Colitis, Ulcerative

Summary: inflammatory bowel disease (ibd) is a term that defines a chronic disease characterized by inflammation of the intestine. it includes ulcerative colitis (uc) and crohn's disease (cd). the objective of the study was to administer a treatment based on a group adaptation of the bmgim in patients with inflammatory bowel disease (ibd) and assess its impact on state of mind, quality of life, anxiety, depression, immunocompetence as a marker of well-being, and levels of acute and chronic stress. to achieve the objectives a quasi-experimental, quantitative, qualitative, analytical, and prospective study was performed. 41 patients with ibd divided into a test group (24 patients), who received 8 sessions over 8 weeks, and a control group (17 patients). a saliva sample was taken from each patient before and after each session to determine cortisol levels (acute stress) and iga (immunocompetence) using elisa. a series of questionnaires were completed as follows: hads (perceived anxiety), mood (state of mind), and ccveii (quality of life). similarly, a hair sample was taken before the first and after the last session to determine the cumulative cortisol level (chronic stress) using elisa.


Eligibility criteria:
inclusion criteria: * over 18 years old, * diagnosed ibd (ec or uc) in the remission phase, * they did not receive treatment with corticosteroids at least in the two months prior to the start of the study, * they did not receive any extra pharmacological treatment, * attend the collaborating hospital center with the study, in this case, the university general hospital of valencia, * attend the schedule and schedule established for the study, * accept the conditions of participation in the study indicated in the signed informed consent prior to the start of the study * \* do not take corticosteroids during the 8 weeks between the pre-test and the post-test, * \* perform the pre-test before starting session 1 (in case of experimental group) or appointment 1 (in case of control group); and then the retest at the end of session 8 (in the case of an experimental group) or appointment with nursing after 8 weeks (in the case of a control group). * \* in the case of the patients belonging to the experimental group, who at the end of the 8 weeks of treatment would have attended at least 6 of the 8 sessions established (and that, obligatorily, 2 of them were 1 and 8, where the shots were taken) sample and completed the questionnaires). exclusion criteria: the patients who were excluded from this study were those who did not meet the requirements indicated in the inclusion criteria, or who showed aversion or rejection to this type of therapy.

Keywords: music therapy
colorectal cancer: screening vs. non-screening

Conditions: Colorectal Cancer; Screening

Summary: the purpose of this study is to determine whether colorectal cancer diagnosed by screening (primary screening colonoscopy, colonoscopy after immunochemical based faecal occult blood test) has more favourable clinical-pathological characteristics than colorectal cancer diagnosed for symptoms. we aimed to compare these two groups of patients at the time of diagnosis and confirm the efficiency of the screening programme.

multicentre prospective observational study. 12 centres across the czech rep. included. study approved by ethical committee. all participants gave their informed signed consent. each centre was assigned a unique id number to distinguish between the locations in which patients were enrolled. patients informations were stored under identification number in secure internet database (redcap) run by the international clinical research center of st. anne's university hospital brno.redcap is a secure, web-based application designed to support data capture for research studies. statistical analysis was done with sas, ver. 9.3. descriptive statistics such as absolute and relative frequencies and median with 95 % confidence intervals were used. differences between the screening and non-screening groups were compared using the chi-square test or fisher's exact test (categorical parameters) and mann-whitney test (continuous parameters). results with a p-value \< 0.05 were considered statistically significant

Eligibility criteria:
inclusion criteria: * newly diagnosed colorectal cancer exclusion criteria: * unsigned informed consent * mental disorder

Keywords: screening ptnm metastasis chemotherapy resection margins colorectal cancer
effect of arginine supplementation in the metabolic syndrome

Conditions: Overweight; Hypertriglyceridemic Waist

Summary: the purpose of this study is to determine whether oral supplementation with one form of arginine improves vascular endothelial function in healthy subjects with risk factors associated with the metabolic syndrome

the study is a randomized crossover study including 32 subjects with risk factors associated with metabolic syndrome. in a cross-over design, each subject received oral arginine and placebo, in a randomized order, and were studied the day preceding the first day of administration of arginine (or placebo) and after 4 weeks of arginine (or placebo) supplementation. the two periods of supplementation were separated by a washout period of at least 4 weeks. the subject were studied in the morning (when before supplementation) and in a whole day (when after supplementation). the mornings cessions consisted of fasting blood draw and vascular explorations, including a measurement of endothelium-dependent brachial artery reactivity ("flow mediated dilation"), directly coupled to a measurement of post-ischemic digital reactivity (with the endo-pat method), completed by a measurement of non-endothelium-dependent brachial artery reactivity. an analysis of the pulse wave geometry was also performed. the whole-day cession consisted of the same fasting vascular explorations. blood tests were performed fasting and repeated 2, 4 and 6 h after ingestion of a high-fat meal (900 kcal). measurements of flow mediated dilation was repeated 4h and postischemic digital reactivity were repeated 2, 4 and 6 h after ingestion of the high fat meal.

Eligibility criteria:
inclusion criteria : * age between 18 to 60 years old * overweight (bmi between 25 and 30 kg/m²) * 'hypertriglyceridemic waist' (waist circumference \> 94cm for men or \> 88cm for women and fasting triglyceride levels \> 150 mg/dl) exclusion criteria : * obesity (bmi\> 30 kg / m²) * cardiac or vascular diseases * diabetes * thyroid disease * systolic blood pressure \> 150 mmhg or diastolic blood pressure \> 90 mmhg * tobacco consumption \> 6 cigarettes per week * alcohol consumption\> 2 drinks per day * any medication (except contraceptive treatment) or dietary supplement intake that could not be arrested more than a week before the first visit for the duration of the study. * persons under guardianship * positive hepatitis b virus (hbv), hepatitis c virus (hcv) and hiv * hemoglobin \< 14 g/dl (for men) or \<12 g / dl (for women) * participation in a clinical trial within 6 months preceding the study * pregnant and lactating women * for women, menstrual cycle with a duration different from 28 (± 1) days (the cycle is not controlled by a contraceptive treatment at 28 days, or he does not appear spontaneously with regularity) * subjects with allergies to final product components * contraindications to arginine intake, namely asthmatics subjects, people prone to herpes, patients with liver cirrhosis and renal failure * hypotensive patients for whom the use of nitroglycerin is contraindicated.

Keywords: arginine supplementation metabolic syndrome endothelial function
a study to evaluate the product performance of a low add multifocal soft contact lens

Conditions: Presbyopia

Summary: the objective of this study is to evaluate the product performance of an investigational multifocal low add soft contact lens.


Eligibility criteria:
inclusion criteria: * have physiologically normal anterior segments. * be adapted wearers of soft contact lenses and wear a lens in each eye. * be presbyopic and require near add correction in each eye. * have no active ocular disease or allergic conjunctivitis. * must not be using any topical ocular medications. exclusion criteria: * any grade 2 or greater finding during the slit lamp examination. * any scar or neovascularization within the central 4mm of the cornea. * any "present" finding during the slit lamp examination that, in the investigator's judgment, interferes with contact lens wear. * allergic to any component in the study products. * any systemic disease affecting ocular health. * using any systemic or topical medications that will affect ocular physiology or lens performance. * an active ocular disease, any corneal infiltrative response or are using any ocular medications.
effect of different feeding modes on psychological condition and experience in stroke patients

Conditions: Ischemic Stroke

Summary: the goal of this clinical trial is to compare the differences on psychological condition and experience in ischemic stroke patients using intermittent oro-esophageal tube and nasogastric tube. patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. on this basis, the observation group will use intermittent oro esophageal tube for enteral nutrition support, while the control group will use nasogastric tube. researchers will compare psychological condition and experience of two groups.

the study will last 15 days for each participant. the goal of this clinical trial is to compare the differences on psychological condition and experience in ischemic stroke patients using intermittent oro-esophageal tube and nasogastric tube. patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. on this basis, the observation group will use intermittent oro esophageal tube for enteral nutrition support, while the control group will use nasogastric tube. researchers will compare psychological condition and experience of two groups.

Eligibility criteria:
inclusion criteria: * age\>18 years. * meeting the diagnostic criteria for ischemic stroke . * dysphagia confirmed by videofluoroscopic swallowing study. * clear consciousness. * stable vital signs. exclusion criteria: * dysphagia that might be caused by other diseases that might cause dysphagia, such as head and neck tumors, traumatic brain injury, myasthenia gravis, etc. * complicated with severe liver and kidney failure, tumors, or hematological disorders. * simultaneously in need to undergo other therapy that might affect the outcomes of this study. * pregnant or nursing females.
consumption of probiotics on salivary bacteria causing dental caries

Conditions: Dental Caries

Summary: dental caries is a multifactorial disease effecting majority of the human population.one of the etiological factor causing dental caries is salivary mutans streptococci. reducing the levels of this bacteria in the saliva can significantly reduce the incidence of dental caries. a non-invasive intervention, such as the administration of probiotics reduced the salivary mutans streptococci levels.

40 candidates were selected from a pre-determined group and were randomly assigned to two groups. group a (n=20) was administered probiotic drink and group b (n=20) was administered placebo for 14 consecutive days. saliva was collected on day 1 and day 15 to compare the salivary mutans streptococci levels.

Eligibility criteria:
inclusion criteria: * decayed missing filled surfaces less than or equal to 6 * brushes twice daily exclusion criteria: * undergoing orthodontic treatment * topical fluoride therapy in the past 2 yrs * using sugar free gums

Keywords: probiotic mutans streptococci bacillus coagulans caries
diagnosis of tuberculosis infection in hiv co-infected children

Conditions: Latent Tuberculosis Infection; Tuberculosis; HIV Infections

Summary: background: the tb and hiv epidemics are closely linked in developing countries, where 450,000 children die from hiv annually. tb is a major cause of death in hiv-infected children and is reversing gains made in child survival. the traditional tuberculin skin test (tst) has limited diagnostic accuracy for detecting tb infection. adult studies suggest that new blood-based diagnostic tb testing offers a quicker, more accurate way to diagnose tb infection. such diagnostic testing may directly guide clinical management and preventive strategies in immune-suppressed hiv-infected children, who are at high risk of becoming tb diseased following infection. data regarding the usefulness of these tests in children is currently limited. objective(s) and hypothesis(es): the investigators hypothesize that blood-based tb diagnostic testing can accurately identify children with tb infection. in a community with high rates of tb and hiv infection, the following specific aims will be investigated in hiv-infected and uninfected children: 1. assess the agreement between the tst and blood-based diagnostic testing, 2. compare the performance of the tst and blood-based diagnostic testing to a standardized history of tb exposure, 3. measure the impact of age, nutritional and immune status on children's response to blood-based testing, 4. describe factors that might modify children's response to testing over time, and 5) examine the effect of environmental exposures and previous vaccination on the tst, blood-based testing and other measures of immune responses to tb. potential impact: the benefits of an accurate, rapid diagnostic test of tb infection in children include 1) timely institution of treatment for tb infection to prevent severe disease and mortality, and 2) preclusion of over diagnosis and treatment. treatment of childhood tb infection also prevents future contagious adult disease, thus decreasing community transmission. blood-based diagnostic testing may also be able to identify children that are more likely to become ill following tb infection. therefore, blood-based diagnostic testing has great potential to improve tb control and the health of hiv-infected and uninfected children, their households and communities.


Eligibility criteria:
inclusion criteria: * age less than 15 years * completion of informed consent exclusion criteria: * less than 3 months of age * documented anemia * recent diagnosis of tuberculosis * receiving treatment for tuberculosis

Keywords: tuberculosis hiv diagnostics pediatrics
positron emission tomography (pet) amyloid imaging of the brain in healthy young adult subjects

Conditions: Healthy

Summary: amyloid is an abnormal chemical found in the brain of patients with alzheimer's disease (ad). the study drug helps produce pictures of amyloid in the brain. the purpose of this study is to determine how well the study drug performs in young healthy subjects.


Eligibility criteria:
inclusion criteria: * the subject age is 18 to 40 years. * the subject has no evidence of thinking or memory problems by medical history. * the subject has a normal mri scan. * the subject's general health is adequate to comply with study procedures. * the subject is willing and able to participate in all study procedures. exclusion criteria: * the subject has received any medical ionizing radiation exposure in the last 12 months (except planar x-ray or head ct). * the subject has a contraindication for (cannot undergo) mri. * the subject has a history of head injury with loss of consciousness. * the subject has any significant medical, psychiatric or neurological condition that might be associated with brain pathology. * the subject has a family history of alzheimer's disease (ad); more than 1 first-degree relative.

Keywords: amyloid magnetic resonance imaging positron emission tomography standard uptake value ratios healthy subjects