Kornimate/medical-research-clean huggingface dataset:
y90 radioembolization prior to surgical resection or radiofrequency for hepatocellular carcinoma in cirrhotic liver

Conditions: Hepatocellular Carcinoma; Liver Cirrhosis

Summary: the purpose of this study is to assess the safety of transarterial radioembolization prior to surgical resection or radiofrequency in cirrhotic patients with hepatocellular carcinoma

the purpose of this study is to assess the peri-operative morbidity and mortality of supraselective ablative transarterial radioembolization prior to surgical resection or radiofrequency in cirrhotic patients with hcc

Eligibility criteria:
inclusion criteria: * age ≥18 years. * cirrhotic liver demonstrated by typical liver dysmorphy on imaging and/or liver biopsy. * hcc with at least one lesion measuring more than 1 cm in diameter with a single dynamic imaging technique (ct or mri), showing intense arterial uptake followed by washout of contrast in the venous-delayed phases, or diagnosed by biopsy. * borderline resectable disease eligible for surgical resection or radiofrequency destruction. * no extra-hepatic dissemination. * ecog performance status \< 2. * women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control, abstinence) prior to study entry and for the duration of study participation. should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately. * signed written informed consent (approved by an independent ethics committee) obtained prior to any study specific baseline procedures. exclusion criteria: * decompensated cirrhosis (child pugh b, c). * extra-hepatic tumour spread. * previous or concomitant malignancies within five years other than basal cell carcinoma of the skin. * pregnancy, lactation or refusal to use adequate contraceptive measures (hormonal or barrier method of birth control, abstinence). * pre-existing other hepatic disease (liver abscess, hepatic sarcoidosis or tuberculosis, sclerosing cholangitis, ...). * previous trans-arterial radioembolization (tare). * history of allergic reactions attributed to compounds of similar chemical or biologic composition of the administered materials. * bleeding diathesis, history of cardiovascular ischemic disease or cerebrovascular incident within the last six months. * major surgery within four weeks. * uncontrolled concurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * uncontrolled diabetes.

Keywords: hepatocellular carcinoma liver cirrhosis radioembolization sirt tare sirspheres neoadjuvant liver cancer
transplantation of basal cell layer suspension using derma-rolling system in vitiligo

Conditions: Vitiligo

Summary: actually the methods for melanocyte delivery are invasive and often sophisticated. the dermarolling system with needles causing tiny microinjuries in the epidermis could offer a minimally invasive and painless method of melanocyte transplantation. the purpose of the study is to develop a new and simple method for transepidermally delivering keratinocytes and melanocytes into vitiligo skin.

condition: stable lesion of non segmental and segmental vitiligo of adults. background: the best method to transepidermally deliver isolated cells (melanocytes) is not yet defined. microneedle treatment of the " ex vivo " human skin caused many thin vertical epidermodermal fissures and a variable depth of injury into the dermis regarding the length of the needles. this kind of treatment could be able to create small epidermal defects which allows to deliver melanocytes to an epidermal site. an approach to replenish melanocytes by injection of dissociated epidermal cell suspension with a syringe was recently successfully used. so, we hypothesize that the use of dermaroller with 0.2mm needle length which causes tiny microinjuries strictly in the epidermis could offer a simple, minimally invasive and painless method of melanocyte transplantation. main objective: to demonstrate the efficacy and the interest of dermaroller use with 0.2mm needle length in the transplantation of basal cell layer suspension in the epidermis of depigmented vitiligo skin. secondary objectives 1. to assess as control the effect of the use of dermaroller alone on the vitiligo lesion. 2. if transplantation is successful, to assess the duration needed to obtain a good coalescence and a complete repigmentation of the vitiligo lesion.

Eligibility criteria:
inclusion criteria: * non segmental and segmental vitiligo lesions stable for a minimum of 1 year prior surgery * men and women aged over 18 years of age * the lesion area must be 2cm2\< lesion\< 15cm2 * absence of infected lesion exclusion criteria: * actively spreading vitiligo (unstable disease) * patient with history of melanoma * infected lesions * positive koebner phenomenon * history of hypertrophic scars or keloid formation * treatment with immunosuppressive or cytotoxic medication the past year * pregnant women and patients aged less 18 years * patients with concomitant photosensitizing treatment * positive serology of herpes, hiv, hepatitis b and c

Keywords: derma-rolling system, vitiligo
the enhance study: exercise and nutrition in head and neck cancer survivors

Conditions: Oral Cavity Cancer; Oropharynx Cancer; Hypopharynx Cancer; Larynx Cancer

Summary: the purpose of the study is to design a physical activity and dietary intervention for head and neck cancer patients.


Eligibility criteria:
inclusion criteria: * \>18 years old * newly diagnosed tumors of the oral cavity, oropharynx, hypopharynx, or larynx * no documented or observable psychiatric or neurological disorders that would interfere with study participation (e.g., dementia, psychosis) * able to speak and read english * able to consume food orally * willing to consume an alternative mediterranean diet * scheduled to receive treatment with radiation or chemoradiation * screened via the physical activity readiness questionnaire (par-q+) with medical clearance of treating physicians, as necessary * able to provide informed consent exclusion criteria: * women who are pregnant * head and neck cancer not the primary diagnosis * patients scheduled to receive surgery * patients on enteral or parental nutrition
eyebag effectiveness in meibomian gland dysfunction

Conditions: Meibomian Gland Dysfunction

Summary: meibomian gland dysfunction (mgd) is a common condition that causes the secretion from meibomian glands in the eyelids to become blocked. normally, the secretion helps to maintain a healthy tear film. in mgd, the tear film becomes unstable and often causes dry eye symptoms. treatments often involve gently warming the eyelids to melt this blockage which prevents tears from spreading over the eye. although there has been some research on application of heat with warm moist flannels, the eye bags potentially offers a simpler and more effective method of applying heat to the eyelids. this study will test the efficiency of these eyelid warming devices over a period of two weeks use in one eye compared to the other non-treated eye.

study design contralateral treatment study randomised eye treated with heated eyebag in the morning and evening each day as per manufacturer's instructions other eye acts as control with room temperature eyebag overlaid in same manner as treatment eye investigators masked sms messaging twice a day for 14 days to remind patients to use eyebag and collect 0-10 comfort score

Eligibility criteria:
inclusion criteria: * 18 or over * have otherwise healthy eyes * are prepared not to wear contact lens for the 2 weeks of the trial * have a nitbut \<10s * osdi score: greater than or equal to 12 * symptom frequency at least "some of the time" * presence of cloudy fluid expressed from at least 1 of the central 8 glands on the lower/upper lid and/or presence of poor expressibility from at least 2-3 of the central 8 glands on the lower lid exclusion criteria: • blepharitis

Keywords: meibomian glad dysfunction eyebag hot compress dry eyes
blood sugar level and postoperative agitations in pediatric surgery

Conditions: Postoperative Delirium

Summary: the aim of this study is to investigate the effect of fasting time and blood glucose levels on postoperative agitations in pediatric patients who will undergo outpatient surgery.

emergence delirium is a very important clinic phenomenon, characterized by irritability and severe restlessness in children recovering from anesthesia; it may cause injury to the child recovering from anesthesia or to surgical site and may also lead to parents, who witness emergence delirium to question the quality of anesthesia. postoperative agitaitons, has been noted with the newer, less soluble inhaled agents and emergence delirium has become a serious problem, taken care in postanesthesia care unit for anesthesiologists. preoperative anxiety, premedication, anesthetic drugs, pain, type of surgery and emergence in a foreign environment are the factors which take part in the development of emergence delirium. emotional and less social children, the children with anxious parents, children undergoing upper airway surgery are under risk. detection of children at risk, the use of appropriate adjuvant drugs, strict control of postoperative pain, and accompanying parents to their children in the recovery room are currently the primary measures to prevent recovery agitation. further studies are required to discover underlying causes and management of emergence delirium. in this study pre-and postoperative blood glucose values, preoperative fasting times and hemodynamic values of 200 american society of anesthesiologists (asa) physical status i-2 patients will be recorded. at the end of the operation, patients will be evaluated with modified aldrete sedation scale, flacc pain rating scale and paed agitation scale. the results obtained will be evaluated with statistical methods and the relationship between preoperative fasting time and blood glucose levels and postoperative agitations will be investigated.

Eligibility criteria:
inclusion criteria: * pediatric patients between 2-12 years of age who will undergo outpatient surgery exclusion criteria: * asa iii-iv patients, patients with congenital malformation and developmental delays, or any neurological or cardiac diseases

Keywords: preoperative fasting time, blood glucose level postoperative delirium
immunologic features of respiratory failure in pediatric hematopoietic cell transplantation (hct) recipients and pediatric oncology patients

Conditions: Respiratory Failure; Respiratory Disease

Summary: this study is being done because researchers want to learn more about genes that control the immune response in the participant's lungs and blood when the participant have lung disease leading to respiratory failure. primary objective to evaluate the feasibility of performing single cell gene expression analyses on tracheal aspirates from immunocompromised pediatric patients with immune compromising conditions, including hct recipients. secondary objectives * to assess whether cell composition and activation states in longitudinally obtained tracheal aspirate and blood samples are able to distinguish unique immunopathology for each of the early post-hct lung diseases. * to assess whether cell composition and activation states in longitudinally obtained tracheal aspirate and blood samples are different between two immunodeficient patient populations (allohct vs non allohct) with lung disease and respiratory failure. * to test the hypothesis that allogeneic t cell responses are implicated in the pathogenesis of early post-hct lung diseases. exploratory objectives to correlate immune cell signaling in the lower respiratory tract and blood of patients with early post-hct lung diseases with the presence or absence of pathogenic microbes at each site. to explore hla testing in tracheal aspirates in samples where enough cells are present.

this study involves a tracheal aspirate, bronchoalveolar lavage (bal), and blood samples. the tracheal aspirates and blood samples will be obtained within 24 hours of intubation, then twice more every 3 -4 days, and then once a week until the patient is extubated. if the primary treatment team performs bronchoscopy with bal, then an aliquot of residual bal fluid will be obtained.

Eligibility criteria:
inclusion criteria: * participant is age 0 to 21 years old * participant has acute respiratory failure due to primary pulmonary disease and is expected to receive invasive mechanical ventilation for more than 48 hours exclusion criteria: * the primary etiology of respiratory failure is not related to primary pulmonary disease * aspiration is present * the participant has a tracheostomy * if the patient has undergone hct, they are more than 100 days removed from hct * has a diagnosis of severe combined immunodeficiency syndrome (scids) * the primary on-service team feels obtaining a study sample would be unsafe for any reason. * inability or unwillingness of research participant or legal guardian/representative to give written informed consent.
effect of dash on hf outcomes heart failure status in older adults (dash hf)

Conditions: Heart Failure

Summary: the purpose of this study is to examine the effect of the dietary approaches to stop hypertension (dash) diet has on heart failure status in older adults. this study is important because it may provide a low-cost strategy to help reduce hospitalizations and deaths for heart failure patients. participants will be adults age 65 and older with heart failure. they will have 4 study visits, each lasting about 2 hours, and will be in the study for 12 weeks. they will also be asked about their dietary consumption 6 times, each time lasting about 45 minutes. all in-person study visits will take place in the emory gcrc. participants will have physical exams, body measurements, blood tests, urinalysis, chart review, and answer surveys. they will be randomized to eat only the dash diet provided to them for 4 weeks either at the beginning or end of their participation in the study. participants will be recruited from heart failure patients at emory university hospital, emory university hospital midtown, and emory outpatient advanced heart failure therapy center. the total enrollment planned under emory's oversight, accounting for screen failures and withdrawals, will be n=38 participants. the study team will obtain informed consent prior to the first study visit either in person, or, alternatively, over the phone, if requested by participants. specimens and data obtained in this study will not be banked for future use.


Eligibility criteria:
inclusion criteria: * 65+ years of age * heart failure diagnosis and symptoms, as outlined by the 2021 european society of cardiology diagnostic guidelines * residence within 50 miles of emory university * have undergone hemodynamic monitoring device implantation (cardiomems, abbott) * have received optimized hf therapy for 3+ months post cardiomems implantation exclusion criteria: * heart failure-related hospitalization or heart failure medication changes within 1 month * renal disease stages iv-v * expected survival \< 12 months * dementia or alzheimer's disease * limited english literacy and communication skills
the impact of legumes vs corn-soy flour on environmental enteric dysfunction in rural malawian children 6-11 months

Conditions: Enteropathy

Summary: to determine if 6 months of legume-based complementary foods is effective in reducing or reversing eed and linear growth faltering in a cohort of malawian children, aged 6-11 months to see if these improvements are correlated with specific changes in the enteric microbiome.


Eligibility criteria:
inclusion criteria: children residing in catchment area of limela, machinga district and ntenda (chikwawa district), malawi aged 6-11 months youngest eligible child in each household - exclusion criteria: unable to drink 20 ml of sugar water demonstrating evidence of severe acute malnutrition apparent need for acute medical treatment for an illness or injury caregiver refusal to participate and return for 3 and 6 month follow-ups - -

Keywords: environmental enteric
induction hypotension in pediatric population

Conditions: Pediatric Surgical Patients

Summary: this is a retrospective chart review to assess the incidence and the degree of blood pressure changes after induction of anesthesia and to study the effect of different induction agents on blood pressure.


Eligibility criteria:
inclusion criteria: * patients between ages of 1 year to 8 years will be included in the study. * patients with asa physical classification 1 and 2 will be studied. exclusion criteria: * patients with any cardiovascular or kidney diseases will be excluded from the study.
renal denervation for the treatment of hypertension: a pilot safety and efficacy study

Conditions: Hypertension

Summary: a single center, self-controlled pilot study on safety and efficacy of renal denervation in treatment of hypertension.


Eligibility criteria:
inclusion criteria: * ages of 18 to 75, male or female; * main renal artery, with or without accessary renal arteries, with length * 20mm; * patients who have not taken any anti-hypertensive drugs or have been off drugs for at least 2 weeks, with mean sbp ≥150mmhg and * 180mmhg based on at least 3 office blood pressure measurements, or asbp≥135mmhg and ≤170mmhg based on 24 hr blood pressure monitoring; * agrees to take part in the trial and signs the written, informed consent. exclusion criteria: * renal artery abnormalities that are inappropriate for the procedure; * pregnant or plan to become pregnant; * history of orthostatic hypotension; * type i diabetes; * estimated gfr\<40ml/min/1.73m2; * only one kidney or prior kidney transplantation; * bleeding tendency or other coagulation related diseases; * acute or severe systemic infection; * prior renal artery interventional procedures or prior rdn treatment; * history of stroke or tia; * malignant tumor or end-stage illnesses; * secondary hypertension; * acute coronary events within 2 weeks; * other conditions that deem unsuitable for the procedure, in the opinions of investigators.
synovitis and therapy response in inflammatory arthritis with contrast enhanced ultrasound

Conditions: Synovitis; Rheumatoid Arthritis

Summary: this study is about using contrast-enhanced ultrasound (ceus) to assess the degree of synovitis (joint inflammation) in patients with inflammatory arthritis, such as rheumatoid arthritis, and whether it can be used for assessing a treatment response. the investigators hope to learn whether contrast enhanced ultrasounds are better than regular imaging techniques, such as mri, when used to evaluate the response to disease modifying anti-rheumatic drug (dmard) therapy in inflammatory arthritis.

inflammatory arthritis affects approximately 1% of the world population and can lead to significant pain and disability. although radiographs can identify characteristic patterns of joint space narrowing and erosive changes, these findings are typically late findings and represent irreversible damage. with the development of disease modifying anti-rheumatic drugs (dmards), the goal is now to identify the pre-erosive inflammatory features and identify the patients that progress further into severe functional debility if not treated immediately. mri with gadolinium enhancement is proven to be very effective in early detection of soft tissue, bone erosions, synovitis, the integrity of ligaments, cartilage and bone marrow edema. however, mri is expensive, may be impractical for assessing multiple joints and has relatively long examination time. some patients may have claustrophobia and some may have contraindications to gadolinium administration. the investigators overarching goal is to determine whether the perfusion information provided by novel ultrasound based techniques such as, contrast enhanced ultrasound and superb microvascular imaging, can be used for assessment of treatment response to dmard therapy for inflammatory arthritis. the recent advances in evaluation of vascularity of the tumors using contrast ultrasound technique can also be applied to rheumatological diseases. it is ideal to develop a sensitive imaging technique that can be routinely available and is relatively cheap. ultrasound is available and has low cost and can be used for assessment of treatment response to dmard therapy

Eligibility criteria:
inclusion criteria: * patients (≥ 18 years of age) that meet diagnostic criteria for an inflammatory arthritis. * clinical suspicion of active synovitis involving at least one target joint. * patients competent to sign study specific informed consent. * patients willing to comply with protocol requirements. * intent to treat with disease-modifying anti-rheumatic drugs (dmards). exclusion criteria: * patients who are pregnant or less than 18 years of age. * patients who have a known cardiac shunt or pulmonary hypertension. * patients with any known hypersensitivity to perflutren or gadolinium contrast agents or renal insufficiency (gfr \< 30 ml/min). * patients who cannot consent for themselves.
xarelto on prevention of stroke and noncentral nervous system systemic embolism in treatment-naïve asian patients with non-valvular atrial fibrillation

Conditions: Atrial Fibrillation

Summary: the purpose of the study is to collect additional information of xarelto treatment in routine clinical practice. patients affected by atrial fibrillation and who will get xarelto as a prophylactic treatment against stroke and systemic embolism (stroke prevention in atrial fibrillation) will be observed.

the study takes place in korea and taiwan. approximately a total of 1200 patients will be included in the study within 12 months. the observation period for each patient is 1 year from enrollment into the study, or until withdrawal of consent or lost to follow-up. patients will be followed according to routine medical practice and the frequency of visits and procedures will be performed under routine conditions.

Eligibility criteria:
inclusion criteria: * female and male patients aged 19 years or older (korea) and aged 20 years or older (taiwan) * diagnosis of nvaf * patients for whom the decision to initiate treatment with rivaroxaban is made as per physician's routine treatment practice * treatment naïve regarding stroke prevention for atrial fibrillation * signed informed consent exclusion criteria: * contraindications for rivaroxaban according to the local market authorization/summary of product characteristics (smpc) * patients participating in an investigational program with interventions outside of routine clinical practice
fiber-optic confocal microscopy of the urinary tract histopathology

Conditions: Bladder Cancer

Summary: the goal of the study is to develop a novel approach to obtain real time optical biopsy of urinary tract pathology (e.g., bladder tumors) during urinary tract endoscopy using a novel fibered confocal microscope.


Eligibility criteria:
inclusion criteria:research subjects with suspected urinary tract pathology (e.g., bladder tumors) who are scheduled to undergo cystoscopy with possible excisional biopsy (e.g. transurethral resection of bladder tumor) in the operating room.\&#xa; exclusion criteria:history of hypersensitivity to fluorescein; active urinary tract infection; pregnant; currently breast feeding;