Kornimate/medical-research-clean huggingface dataset:
pulsed-dye laser treatment prior to surgical excision

Conditions: Cicatrix

Summary: this prospective pilot study will investigate whether use of a pulsed dye laser (pdl) prior to surgical excision can improve the appearance and symptoms of scars. the primary outcome measurement for the study is the quality of the scar in areas pre-treated with pdl vs. control (cryogen spray only). for this study, subjects who are scheduled for a dermatologic surgical excision will have half of the surgical area pre-treated with pdl and the other half pre-treated with cryogen spray.


Eligibility criteria:
inclusion criteria: * subjects with ages between 18 and 65 years, who are scheduled for a dermatologic surgical excision * subjects requiring surgical excisions for any condition * subjects with any fitzpatrick skin type * willingness to participate in the study * willingness to receive experimental treatment * informed consent agreement signed by the subject * willingness to follow the follow-up schedule * willingness to not use any other scar treatments during the study period (i.e scar massage, over-the-counter silicone pads, intralesional steroid of 5-fluorouracil injections, laser treatments) exclusion criteria: * pregnancy * prior scar in area to be treated * known photoallergy to visible light (i.e polymorphous light eruption) * subject is unable to comply with treatment or follow-up visits * subject with a history of being on photosensitive medications for the past 3 months (thiazides \[used to treat high blood pressure\], tetracyclines, fluoroquinolones griseofulvin or sulfonamides \[used to treat infections\], sulfonylureas \[used to treat diabetes\], calcium channel blockers \[used to treat hypertension\], phenothiazines \[used to treat serious emotional problems\]). * known autoimmune disease (some autoimmune diseases can lead to sensitivity to light, such as lupus erythematosus) * subject is currently enrolled in a clinical study of any other unapproved investigational drug or device

Keywords: scar pulsed-dye laser pdl
effect of exercise or metformin on nocturnal blood pressure and other risk factors for cvd among obese adolescents

Conditions: Cardiovascular Diseases

Summary: the objective is to, among obese adolescents, study impact of regular physical activity or metformin therapy on nocturnal blood pressure and related cardiovascular disease risk factors.

forty subjects will be assigned to the exercise intervention group, thirty to the metformin therapy group and thirty to the control group. group i will be treated daily with metformin. group ii will perform exercise (endurance) three times/week with a personal coach and group iii will serve as control. all participants will be examined at baseline, after 3 months of intervention, after 6 months of intervention and after one year of intervention. examination includes anthropometric measures, measures of ambulatory 24-h blood pressure and insulin sensitivity, measures for function and structure of the heart and vessels, analysis of atherogenic factors in the blood, aerobic fitness testing and measurement of daily physical activity.

Eligibility criteria:
inclusion criteria: * age 13-19 years old at inclusion date * obesity according to gender and age specific bmi (cole 2000) * reduced nocturnal systolic blood pressure fall (\< 10%) * signed informed consent by patient and parents exclusion criteria: * cardiovascular disease * insulin dependent diabetes mellitus * patient on medications that are contraindicated during metformin treatment * pregnancy * mental or physical conditions limiting the ability to participate

Keywords: obesity adolescents nocturnal blood pressure reduction insulin metabolism cardiovascular structure and function treatment exercise metformin insulin blood glucose impaired nocturnal blood pressure reduction
step down inhalers in the real world

Conditions: Chronic Obstructive Pulmonary Disease

Summary: to establish the feasibility of stopping inhaled steroids and switching or maintaining dual bronchodilation in one visit - in the real world, for people with copd.

copd patients prescribed a combination of any inhaled corticosteroid (ics), long acting beta agonist (laba) and long acting muscarinic antagonist (lama) will be switched to a single laba/lama combination inhaler, stopping their ics. they will be followed up for 12 months. participants are shown the four currently available laba/lama combination inhalers and instructed on their use. the clinical specialist will use standard prompts in an effort to demonstrate the inhalers in an unbiased way. the participants will choose: ultibro® (breezhaler device) or duaklir® (genuair device) or anoro® (ellipta device) or spiolto® (respimat device) and they will be prescribed the inhaler of their choice provided they can demonstrate effective use. patients will be reviewed 4, 12, 26 and at 52 weeks after switching with clinical outcomes measured at these points. as this is a real-world open study the patients and gps are instructed that treatments can be changed at any point as clinically indicated, including restarting an ics.

Eligibility criteria:
inclusion criteria: * gp diagnosis of copd * post bronchodilator fev1/fvc ratio \<70% with fev1\<80% predicted * current or ex smoker equal or greater than 10 pack years * taking an ics, laba \& lama exclusion criteria: * unable or unwilling to sign informed consent * any previous or current diagnosis of asthma * any features of asthma or large variability in symptoms * history of atopy * any previous blood eosinophil count \>600mm3 * a moderate or severe exacerbation of copd (needing systemic glucocorticosteroids or hospital admission for \>24 hours) within the last 6 weeks * life expectancy \< 1 year

Keywords: copd
study of the effectiveness and safety of desloratadine (aerius) syrup in children with allergic skin inflammation (p03475)

Conditions: Dermatitis, Atopic

Summary: the purpose of this study was to test the effectiveness and safety of desloratadine (aerius) syrup in children with allergic skin inflammation. patients took desloratadine syrup once a day for 28 days. once a week, the doctor measured the patient's symptoms. this measurement is called scorad. the doctor also rated how much relief the patient got from treatment and recorded any side effects.


Eligibility criteria:
inclusion criteria: * children must be from \>= 6 to \< 12 years of age, of either sex and any race. * children's parent(s) or legal representative(s) must demonstrate their willingness to participate in the study and comply with its procedures by signing an informed consent. * children must be in general good health; i.e. they must be free of any clinically significant disease other than atopic dermatitis (ad) that would interfere with study evaluations. * children's parent(s) or legal representative(s) must understand and be able to adhere to the dosing and visit schedule, and agree to report concomitant medications and adverse events to the investigator or designee. * the diagnosis of ad will be performed according the hanifin and rajka criteria (hanifin jm, rajka g. diagnostic features of atopic dermatitis. acta derm venereol (stockhr) 92 (suppl): 44-70, 1980): to be included in this study, children needed to manifest at least 3 major features and 3 minor features at visit 1 (day 1). * children must be clinically symptomatic with ad at visit 1 (day 1). disease severity will be estimated using the scorad index (european task force on atopic dermatitis. severity scoring of atopic dermatitis: the scorad index. dermatology 186: 23-31, 1993), and child must have a scorad index at least \>= 35. exclusion criteria: * children who have not observed the designated washout period for any of the prohibited medications. * children with bronchial asthma who require chronic use of inhaled or systemic corticosteroids. * children with a history of hypersensitivity to desloratadine, or any of its excipients. * children who have any current evidence of clinically significant hematopoietic, metabolic, cardiovascular, immunologic, neurologic, hematologic, gastrointestinal, hepatic, renal, psychiatric, or cerebrovascular, or any other disorder which, in the judgment of the investigator, may interfere with the study evaluations or affect children safety. * a known lack or response to h1-antihistamines.
angiotensin converting enzyme gene polymorphism in children with idiopathic nephrotic syndrome

Conditions: Nephrotic Syndrome

Summary: aims this study was conducted to examine the association between the ace insertion/deletion (i/d) genotype distribution in children with idiopathic nephrotic syndrome and the response to steroid therapy. patients and methods the patients with idiopathic nephrotic syndrome were divided into 2 groups according to their clinical response to steroid: ss group including infrequent and frequent relapsers and non-ss group including steroid resistant (sr) and steroid dependent (sd) patients. children without previous renal diseases and negative proteinuria were enrolled as control group in genetic study. the genotypes for ace gene i/d polymorphism including dd, id and ii were analyzed by the newly developed automatic denaturing high performance liquid chromatography system (dhplc).


Eligibility criteria:
inclusion criteria: * total 59 children diagnosed as nephrotic syndrome at the age of 1 to 10 year-old were recruited in this study. these children with nephrotic syndrome were under follow-up at the pediatric nephrology clinic in national taiwan university hospital. in addition, children without previous renal diseases and negative proteinuria were enrolled as control group in genetic study.
dose-response of albuterol in asthmatics

Conditions: Asthma

Summary: the purpose of this study was to determine the lung function response after increasing doses of albuterol (a bronchodilator) in children and adults with asthma.

inhaled short-acting b2-agonists (saba) are the most potent bronchodilators used today to treat acute symptoms of asthma and albuterol, a partial b2-agonist, is the most frequently prescribed asthma medication in the us. although universally used in for acute asthma symptoms, saba have been associated with a significant degree of interpatient variability. many studies have characterized the saba dose to bronchodilator response relationship under controlled conditions. however, few studies have explored the magnitude and sources of bronchodilator response variability, and no studies have characterized the dose versus bronchodilator response relationship using population pharmacokinetic/pharmacodynamic (ppk/pd) modeling. in the present study, we characterized the relationship between inhaled doses of albuterol and bronchodilation in 81 children and adults with moderate to severe persistent asthma using a population pharmacodynamic approach. the purpose of this study was to obtain estimates of the pharmacodynamic parameters that characterize the dose-response curve, including maximal dose for bronchodilation, and to quantify and identify sources of interpatient pharmacodynamic variability.

Eligibility criteria:
eligibility criteria: * well-defined history of physician diagnosed asthma * any ethnic background * 8 to 65 years old * baseline pre-bronchodilator fev1 of 40% to 80% predicted for age, height, and gender * no oral corticosteroid use, emergency room visits, or hospitalizations within the previous 3 months * nonsmokers or less than a 5 pack-year history with no smoking in the previous year * normal physical exam and no confounding diseases were selected * able to withhold inhaled short-acting b2-agonists or inhaled anticholinergic drugs for 8 hours, oral antihistamines for 5 days, theophylline for 24 hours, and cromolyn, nedocromil, and inhaled corticosteroids for 2 hours prior to the study.

Keywords: albuterol forced expiratory volume in one second dose at fifty percent of maximum effect maximum effective dose metered dose inhaler nebulizer
malnutrition clinical characteristics validation study

Conditions: Malnutrition

Summary: malnutrition (under-nutrition) occurs in approximately 30% of hospitalized adults worldwide and results in poor outcomes. however there is no universal method for diagnosing malnutrition. a group of experts created a set of 6 characteristics to identify malnutrition. the goal of this project is to determine whether these characteristics are the best indicators to identify malnutrition or if there are other factors that may better identify malnutrition. because there is no gold standard definition for malnutrition, the investigators will compare the characteristics against outcomes such as length of stay, hospital readmission and death. outcomes are also influenced by disease state, therefore, information on what brought the patient to the hospital and what happened to them in the hospital will be collected that allows the investigators to separate the effect of malnutrition from disease. the hypothesis for this study is that the malnutrition clinical characteristics and diagnosis criteria, as presented by the experts, are valid and reliable principles for the diagnosis of adult under-nutrition.


Eligibility criteria:
inclusion criteria: * patient on inpatient dietitian consult list * able to speak english to answer questions * ability to provide informed consent (or provided by family member) * expected remaining admission time \> 24 hours (determined by no mention of pending discharge in physicians notes) * age ≥ 18 years exclusion criteria: * seen previously by registered dietitian during current admission * patient on hospice or palliative care, in a psychiatric, maternity, pediatric or day surgery area, or in dedicated trauma or burn unit. * life expectancy \<7 days per physician note or registered dietitian (rd) judgment * participated in the study during a previous admission
effect of self assembling peptide on white spot lesion

Conditions: White Spot Lesion of Tooth

Summary: during re-mineralization of white spot lesion, will biomimetic self-assembling peptides improve the re-mineralizating effect of the post orthodontic white spot lesion compared to fluoride-based delivery systems?

conservative dentistry no longer prefers the "drill and fill" concept and advocates reversal of lesions via remineralization. . remineralization is the process of restoring minerals - again, in the form of mineral ions - to the hydroxyapatite latticework structure. it is three-dimensional, and the lost ions must be replaced with ions having the exact same shape, size and the same electrical charge as those lost from the lattice. fluoride and self-assembling peptides have been used as adjuncts to enhance remineralization.

Eligibility criteria:
inclusion criteria: * patients with post orthodontic white spot lesion. * patients with good oral hygiene. * patients with good general health. * cooperative patients. * subjects who signed the informed consent. exclusion criteria: * patients with tetracycline pigmentation and dental fluorosis. * enamel cavitation. * disable patient. * patient with any systemic disease or severe medical complications.
neural mobilization with task based activities on upper limb in patients with chronic stroke.

Conditions: Chronic Stroke

Summary: stroke is defined as sudden neurological disruption of blood supply to brain. it is most common disease that causes severe disabilities like hemiparesis which is most common motor impairment that leads to persistent upper limb dysfunction. in this study we use two techniques to improve upper limb motor dysfunction and reduce spasticity. one is task-based activities which is used to improve motor function and focus on active participation rather than normal movement pattern and other is neural mobilization which aims to reduce spasticity which is most common in stroke patients.

this study will be randomized controlled trial. participants having stroke past 6 month to 1 year and mini mental state examination score \>21 will be included in this study. and participants with severe orthopedic deformity, joint pain and visual impairment will be excluded from this study. the sample size will consist of 34 participants selected through non probability convenient sampling technique, which will further be randomized through sealed envelope method and will divide into two groups .data will be collected using assessment tools, including the fugl mayer assessment scale, box and block test and wolf motor function test. 17 participants will be assigned to the interventional group (a )which will undergo neural mobilization of median nerve with task based activities .neural mobilization technique will be performed with twenty oscillations per minute being repeated three sets of one minute respecting one minute interval for rest between each set for 4 days weekly for 6 week. while task based activities will be performed with the dosage of 45 minutes session 5 days weekly for 6 weeks and 17 participants will be assigned to control group (b )which will undergo only neural mobilization of median nerve and will receive neural mobilization with twenty oscillations per minute being repeated three sets of one minute respecting one minute interval for rest between each set for 4 days weekly for 6 weeks. after applying both interventions motor function improvement and spasticity reduction will be measured by using bbt, wolf motor scale and fugl -meyer assessment scale and data will be analyzed through spss version 25.

Eligibility criteria:
inclusion criteria: * male and female stroke patients. * 6 month to one year post stroke . * age 30-55 * stable patients * mini - mental state examination\>2 * modified ashworth scale equal\<+1 exclusion criteria: * orthopedic deformity * patients undergo bottulinuminjection toxin injection * visual impairments * joint pain (elbow, shoulder, wrist)

Keywords: neural mobilization
assessment of respiratory function cerebral palsy using plyometric exercise sensorimotor program

Conditions: Cerebral Palsy

Summary: to examine if adding plyometric exercises to sensorimotor exercises would improve respiratory function in children and adolescents with cerebral palsy

cerebral palsy (cp) is a varied group of developmental disorders secondary to a static immature brain injury that primarily results in persistent nonspecific impairment of movement and posture. approximately 25% of all cp cases experience disturbance of motor function with unilateral spasticity pertaining to the upper and lower extremities contralateral to the affected cerebral hemisphere and categorized as spastic hemiplegia. some asymmetries might be noted when hemiplegic children are attempting to perform motor activities. in supported standing, hemiplegic children may stand preferentially on their more functional side and exhibit postural malalignments that impair the ability to transfer body weight on the affected lower extremity. children and adolescents with cp have poor respiratory function, secondary to the disease process. impaired airway clearance, recurrent aspirations, chest infections, poor cough mechanism, impaired lung function, deformity of the spine and chest, and poor nutrition status influence the respiratory condition of children and adults with cp resulting in reduced lung capacity in these individuals. plyometric exercises are a specific pattern of resistive strength training in which the muscle starts to contract eccentrically followed by rapid concentric contraction of the same muscle. it can jointly generate high velocity dynamic movements and high-impact force on the muscles and bones. currently, a limited number of studies have analysed the efficacy of the plyometric training on respiratory function in children with cp or any other disabling health conditions. preliminary studies have demonstrated the positive effect of plyometric exercises for the gross motor function in boys with unilateral cp.

Eligibility criteria:
inclusion criteria: * age will be 8 - 14 years. * children will be assigned to the study are suffering from spastic hemiplegic cerebral palsy (less than grade 1+ om modified ashwar scale) * considering the physical problems, children will be chosen according to growth motor function classification system (gmfcs) with levels i-iii * the ability to understand simple verbal instructions. exclusion criteria: * visual and hearing impairment; surgery within the last three months preventing them from taking part in sensorimotor physical therapy * severe oromotor issues * severe chest infections

Keywords: respiratory capacity cerebral palsy plyometric exercise
a low fodmaps diet in celiac patients with persistent gastrointestinal symptoms

Conditions: Celiac Disease

Summary: fodmaps (fructose, oligosaccharides, monosaccharides, disaccharides and polyols) are characterised as fermentable but poorly absorbed carbohydrates which enter the colon and are utilised by colonic bacteria. during fasting colonic nutrients are scarce but ingesting fodmaps causes a rapid increase in carbohydrate which can overwhelm the microbiota's ability to utilise substrate. the excess reducing equivalents will generate hydrogen or methane. the principal symptoms are diarrhoea and abdominal distension. patients with irritable bowel syndrome appear to benefit by restricting intake, possibly because they are hypersensitive to intestinal distension. the focus of the study is to evaluate if in celiac patients with persistent abdominal symptoms and with a correct gluten free diet, a low fodmaps diet can improve their symptoms. moreover the study would like to observe if a dietary restriction in fodmaps carries the risk of nutritional inadequacy.


Eligibility criteria:
inclusion criteria: * celiac patients assessed through positive serology and histology * functional patients according ibs roma iii criteria * subjects with vas\>5 exclusion criteria: * refractory celiac disease * disaccharide intolerance (fructose an lactose breath test) * abdominal surgery * comorbidity * patients recruited in other clinical trials * positive patients at lactulose breath test (sibo)

Keywords: fodmaps diet micro-macro nutrients intake ibs (irritable bowel syndrome)