Kornimate/medical-research-clean huggingface dataset:
effectiveness of health literacy enhancement program among older persons with physical multimorbidity

Conditions: Multiple Chronic Conditions；Diabetes；Hypertension

Summary: the study aims to examine the effectiveness of individual and family health literacy enhancement program among older persons with physical multimorbidity. specific objectives are: 1. to compare self-management, treatment burden, and symptom burden of older persons with physical multimorbidity between before and after receiving the individual and family health literacy enhancement program. 2. to compare self-management, treatment burden, and symptom burden of older persons with physical multimorbidity between those receiving the individual and family health literacy enhancement program and those receiving usual care. participants in the control group will receive usual care by physician and nurses during the experimental period. the usual care consists of physical examination, regular treatment protocol, patient education and telephone follow-up by community nurses. participants in the interventional group will receive the program which is a group-based intervention developed by the researcher based on the individual and family self-management theory (ifsmt) (self-management skills) and the principle of medagogy (pits model: pathophysiology, indications, treatments, specifies) to improve patients' and their families' understanding of disease-related information and self-management skills consisting of goal setting and action plan, self-monitoring, solving problems and decision-making, and emotional control.the program will be divided into 8 sessions. each session will be lasted for 2 hours with 1 intermittent break (10 minutes), and it will be held twice a week, and the last session will be held 1 week after the 7th session. therefore, it will last for 5 weeks in total.


Eligibility criteria:
inclusion criteria: * age 60-80 years old; * having been diagnosed with hypertension and type 2 diabetes for at least 6 months; * being able to read and write chinese language; * cognitive intact as measured by the mini-mental state examination (mmse) with the score ≥ 24; * physically independence as measured by the barthel adl index and the score above 12 out of 20 ; * willing to participate in the study; * having at least a family member who is willing to participate in the study. exclusion criteria: * having other diseases or severe complications from their health problems that making them unable to fully participate through all process of the program including ischemic heart disease, myocardial infarction, heart failure, stroke, acute renal failure, diabetic ketoacidosis, and diabetic coma;

Keywords: aged; multimorbidity; health literacy; self-management.
effects of different positions on mechanical traction outcome

Conditions: Non-specific Low Back Pain; Lumbar Traction

Summary: our primary purpose for this study is to investigate the effect of different positions during traction on pain, function, and range of motion in adults with non-specific low back pain.


Eligibility criteria:
inclusion criteria: * adult 18-65 years of age * non specific lbp persisted for more than 12 weeks * at least 4/10 on nprs exclusion criteria: * vertebral fractures * axial spondylarthritis * aauda equina syndrome * radicular pain * radiculopathy * spinal stenosis * spinal surgeries * malignancy * pregnancy * inflammatory or infectious cases of lbp
external beam radiation therapy - target volume

Conditions: Prostatic Neoplasms

Summary: delivery of conformal radiation therapy following radical prostatectomy is limited by the inability to define the clinical target volume (ctv). this stems from a poor understanding of patterns of local recurrence and limitations of standard imaging techniques.magnetic resonance imaging (mri) is a promising modality for imaging the prostatic bed following radical prostatectomy. mri provides more detailed postoperative anatomy to guide ctv delineation, the ability to document local recurrence patterns, and a method to assess intrafraction prostatic bed motion and deformity to define appropriate planning target volume margins. the aim of this pilot study is to develop a technique for external beam radiation therapy (ebrt) following radical prostatectomy based on mri-delineation of the ctv. twenty patients will be enrolled in this pilot, development phase.


Eligibility criteria:
inclusion criteria: * patients following radical prostatectomy for prostate adenocarcinoma with one or more of the following adverse features: pt2 + positive surgical margins ) pt3 ) psa ≤ 2ng/ml persistently elevated psa at 3 months ) * patients with initially undetectable psa following prostatectomy for prostate adenocarcinoma with subsequent psa relapse * patients being planned for radiation therapy * no evidence of distant metastases * age ≥ 18 years * ecog performance status 0 or 1 * informed consent exclusion criteria: * contraindications to mri patients weighing \>136 kgs (weight limit for the scanner tables) patients with pacemakers, cerebral aneurysm clips, shrapnel injury or implantable electronic devices not compatible with mri. * severe claustrophobia * inflammatory bowel disease or collagen vascular disease * previous colorectal surgery * previous pelvic radiotherapy
assessment of robotic versus laparoscopic gastrectomy for gc patients with intraoperative technical complexity

Conditions: Gastrectomy for Gastric Cancer; Robotic Surgical Procedures; Laparoscopic Surgical Procedures

Summary: while robotic gastrectomy (rg) is increasingly used in gastric cancer surgery, its potential advantages over laparoscopic gastrectomy (lg) in intraoperative technical complexity (itc) cases remain debated.

this retrospective cohort study included 3,534 patients with gastric cancer who underwent radical gastrectomy at eight high-volume hospitals. itc was defined by any of the following criteria: operative time exceeding the third quartile, intraoperative estimated blood loss ≥ 400 ml, or conversion to open surgery. propensity score matching (psm) and inverse probability of treatment weighting (iptw) were conducted to compare short- and long-term outcomes.

Eligibility criteria:
inclusion criteria: * patients with postoperatively histologically confirmed t1-4an0-3bm0 gastric adenocarcinoma who underwent rg or lg exclusion criteria: * remnant gastric cancer * previous malignant * asa class \>3 * use of indocyanine green * neoadjuvant chemotherapy * loss to follow-up * combined resection

Keywords: surgical difficulty gastrectomy robotic laparoscopic
screening diva - diffuse vascular disease

Conditions: Peripheral Vascular Diseases

Summary: primary objective: to investigate the value of the edinburgh claudication questionnaire (ecq) against the ankle-brachial index (abi) in canadian patients mainly followed in general practice, with documented acute coronary syndrome (acs)/ischemic stroke (is)/transient ischemic attack (tia) and who are not known to have peripheral arterial disease (pad) at the time of enrolment. secondary objective: to collect data on the prevalence of pad in this population as measured by abi.


Eligibility criteria:
inclusion criteria: * documented acute coronary syndrome (unstable angina, non-q-wave myocardial infarction, q-wave myocardial infarction) or/and documented ischemic stroke/transient ischemic attack (is/tia) exclusion criteria: * previously known symptomatic or asymptomatic pad confirmed by one of the following diagnostic methods or interventions (documented in the patient's medical record): * non-invasive or invasive vascular diagnostic tools (e.g.: abi, toe-brachial index, duplex ultrasound, magnetic resonance angiography, computer tomographic angiography, contrast angiography) * previous related intervention (such as angioplasty, stenting, atherectomy, peripheral arterial bypass graft, other vascular intervention including amputation) * patients whose abi cannot be measured accurately * patients already in a clinical trial or a product registry * hospitalized patients the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
anagrelide vs. hydroxyurea - efficacy and tolerability study in patients with essential thrombocythaemia

Conditions: Essential Thrombocythaemia

Summary: study aop 03-007 was designed as a pivotal study to test, if anagrelide (thromboreductin®)was not inferior to hu with respect to efficacy in patients with et. this approach to demonstrate non-inferiority was based on the following decision points: • et is a rare disease and recruitment of large patient number (\> 1600) to prove superiority was not considered possible. . it was decided to recruit only treatment naïve high risk patients to avoid pre-treatment bias, which further limited the number of patients eligible for the study.


Eligibility criteria:
inclusion criteria: * presence of essential thrombocythaemia with high-risk profile. exclusion criteria: * previous treatment with cytoreductive drugs or anagrelide * pregnant women or women in childbearing age with inadequate contraception * patients with contraindications for study drugs due to anaphylactoid reactions to either active or non-active ingredients * known lactose intolerance * cardiovascular diseases grade iii-iv (toxicity criteria of the south west oncology group, 1992) - with a negative benefit/risk ratio * severe renal disease (creatinin clearance \< 30 ml/min) * severe liver disease (ast or alt \> 5-times normal) * coexisting, malignant, systemic diseases
esophageal fistula after anterior cervical decompression and fusion

Conditions: Esophageal Fistula

Summary: this study aims to evaluate the incidence, risk factors, and preventive measures of esophageal fistula following anterior cervical decompression and fusion. by understanding the mechanisms and clinical manifestations of this complication, the study seeks to provide clinicians with better guidelines for treatment and improve postoperative outcomes for patients.


Eligibility criteria:
inclusion criteria: patients aged 18 and older. diagnosed with a secondary esophageal fistula following anterior cervical decompression and fusion surgery. postoperative confirmation of the esophageal fistula via imaging studies or endoscopy. presence of clinical symptoms such as dysphagia, coughing, or signs of infection. patients or their legal representatives must provide informed consent. exclusion criteria: preexisting esophageal diseases such as esophageal cancer, severe esophagitis, or congenital anomalies. other types of fistulas not related to the surgery. severe comorbid conditions, including: uncontrolled diabetes, severe cardiovascular diseases, immunosuppression, pregnant women. individuals unable or unwilling to comply with study protocols. life expectancy of less than six months due to other underlying health conditions.
ucad for diagnosing benign or malignant gallbladder diseases and follow-up

Conditions: Gallbladder Cancer

Summary: copy number variation(cnv) refers to ongoing chromosome segregation errors throughout consecutive cell divisions. cnv is a hallmark of human cancer, and it is associated with poor prognosis, metastasis, and therapeutic resistance. analyzing cnv of the dna extracted from bile samples in gallbladder seems a promising method for diagnosing, monitoring, and predicting the prognosis of patients with gallbladder cancer. cnv can be assessed using experimental techniques such as bulk dna sequencing, fluorescence in situ hybridization (fish), or conventional karyotyping. however, these techniques are either time-consuming or non-specific. the investigators here intend to study whether a new method named ultrasensitive chromosomal aneuploidy detection (ucad), which is based on low-coverage whole-genome sequencing, can be used to analyze cnv thus helping diagnose gallbladder cancer and assessing follow-up.


Eligibility criteria:
inclusion criteria: * patients diagnosed with gallbladder disease and planned to undergo surgery. * male or female patients aged \>= 18 years. * participants signed informed consent form. exclusion criteria: * participants had other tumor expect gallbladder cancer

Keywords: diagnosis
electrocochleography function for monitoring residual hearing

Conditions: Hearing Loss, Cochlear

Summary: this trial is a pilot study to assess the feasibility of using electrocochleography recorded from a cochlear implant intra-operatively in real time to monitor the progress of its insertion. correlation between: 1. observed changes in this signal during surgery and residual hearing loss post-operatively and 2. recordings of this signal post-operatively and actual pure tone audiometry results will also be assessed.

cochlear implants (cis) can provide deaf individuals the ability to hear. cis are electronics packages inserted into the cochlea (hearing organ). an external processor digitises sound and transmits it to the implant. an electric stimulus from the implant mimics the change in electrical potential normally caused by the movement of stereocilia in the cochlea when a sound occurs. this change generates an impulse along the auditory nerve to the brain resulting in perception of sound. cis are available in the uk to people who have profound hearing loss. the improvement of ci technology means individuals with less significant losses, or profound losses at only some pitches may now benefit from a ci over a hearing aid. patients having useful residual hearing has led to interest in better preserving that hearing during surgery. thus allowing benefit from traditional acoustic amplification in addition to electrical stimulation from the implant. the investigators propose recording a measurement via the implant during surgery and at audiology appointments called a cochlear microphonic using a technique called electrocochleography (ecochg). this is essentially recording the electrical signal generated by the movement of hair cells in the cochlea in response to a sound. it is hypothesised that reduction of this signal during implantation may correspond to cochlea damage occurring and that with development this signal might be useful feedback for surgeons. the signal is known to be correlated to actual hearing ability so a better understanding of this may allow us to fit the acoustic amplification portion of implants in individuals who are unable to respond reliably to a normal hearing test. the purpose of this study is a pilot to assess the correlation between observed changes in this signal during surgery and residual hearing loss post-operatively and the degree correlation between recordings of this signal post-operatively and actual hearing test results.

Eligibility criteria:
inclusion criteria: * meets normal candidacy requirements for cochlear implantation * at least 1 year of age at time of consent being given * patent cochlea as verified by ct or mri scan * no cochlear abnormality that might prevent insertion of the electrode array * measurable residual hearing in the ear to be implanted * no additional complex needs that would prevent study procedures or normal clinical follow-up protocol being followed * ab implant selected by patient or mdt * written informed consent obtained exclusion criteria: * medically complex cases where minimal duration of surgery is required

Keywords: cochlear implant electrocochleography
impact of exercise on the metabolic consequences of overeating

Conditions: Healthy

Summary: the primary purpose of this study is to examine the effects of 1-week of overeating on important clinical metabolic health outcomes (e.g., glucose tolerance, blood lipid profile, and blood pressure) and factors regulating the structure and metabolic function of fat tissue. this study will determine how regular exercise during this overeating period impacts these responses.

if subjects are eligible and decide to participate, they will take part in two identical study trials. one is scheduled before and the other is scheduled after 1 week of overeating controlled by the study team. subjects who exercise regularly will be instructed to exercise the day before their first study trial - and they will be required to exercise during 6 of the 7 days of the overeating period (including the day before their second study trial). subjects who do not regularly exercise (no planned physical activity) will remain inactive until the completion of both study trials. before each study trial if a subject is a regular exerciser, they will be asked to come to the substrate metabolism laboratory in the afternoon before each of the 2 study trials to exercise in the lab for 45 min at a moderate intensity. the evening before the study trial, all subjects will need to eat a standardized dinner meal and snack. they must eat the meal and snack at specific times as indicated by the research staff. after eating the snack, subjects will need to fast (no food or beverages - besides water) overnight. during each study trial subjects will arrive at the substrate metabolism laboratory at 7:00am and will rest quietly for approximately 30 min. after which, the study team will measure their resting blood pressure and their resting metabolic rate. an intravenous catheter (iv) will then be placed in a vein of the subject's hand or forearm for blood sampling. the research team will then collect a small sample of fat tissue in the subject's abdomen with a needle. next, subjects will drink a sweet sugar solution for an oral glucose tolerance test (ogtt) and the research team will collect blood samples every 15 min for 3 hours. after this 3 hour test, the iv catheter will be removed and subjects will be provided breakfast and discharged.

Eligibility criteria:
inclusion criteria: * age: 18-40 * body mass index: 20-30 kg/m2 * exercise group: (≥5 days/wk of aerobic exercise; 30-60min/session at moderate and vigorous intensities) * no exercise group: no regularly planned exercise/physical activity * women must have regularly occurring menses and must be premenopausal exclusion criteria: * pregnant or lactating * blood pressure \> 140/90 mm hg * evidence/history of cardiovascular or metabolic disease * medications known to affect lipid or glucose metabolism * tobacco or electronic cigarette user
radix 2 renal stent post-market retrospective study

Conditions: Renal Artery Stenosis; Renal Failure

Summary: the carbostent™ radix 2 stent is a ce marked balloon expandable bare metal stent for the treatment of renal artery stenosis. the aim of this post-market retrospective study protocol p12204, is to collect clinical data on patients treated with the radix 2 stent in routine clinical practice. in order to obtain long-term follow-up data, the data collection will be limited to patients that have been treated with the radix 2 stent at least 12 months prior to the study start.

the objective of this post-market study is collect retrospective clinical data on the implantable medical device radix 2 stent in an unselected population treated in the current clinical practice. data will be collected via medical chart review in anonymous form. radix2 is a bare metal balloon expandable stent with a progressive multicellular design for treatment of renal artery stenosis. the stent is stent coated with i-carbofilm™ to accelerate the rate of endothelization and strut coverage. the product is ce marked and commercially available since july 2010. additional technical information on radix2 is available online: http://www.alvimedica.com/product/15/bms-b-e-radix2

Eligibility criteria:
inclusion criteria: the study will be conducted in the "real world" population, according to the following criteria. selection criteria: * patient has been implanted with at least one study stent (radix2) according to the indications described in the ifu. * study device implanted is at least12 months prior to the starting date of the retrospective anonymous data collection. exclusion criteria: * patients treated less than 12 months prior to study start
vr vs. conventional cycling exercise for geriatric inpatient physical activation

Conditions: Inactivity, Physical; Treatment Adherence and Compliance; Hospital Acquired Condition; Sarcopenia

Summary: the aim of this study is to investigate whether virtual reality assisted stationary cycling exercise results in more physical activity than conventional unsupervised stationary cycling exercise. physical activity levels are reported for both exercise duration and volume and non-exercise activity.


Eligibility criteria:
inclusion criteria: * admitted to geriatric ward at bispebjerg hospital with an minimum of 3 days (anticipated) left of stay. * volunteering exclusion criteria: * unable to be easily mobilized by training staff. * unable to perform the stationary cycling exercise modality. * lack of danish speaking and reading skills. * lack of senses (blind, deff pr heavily hearing impaired). * suffering from delirium, vertigo or dementia beyond a moderate degree. * judged medically contraindicated by therapeutic, medical or care staff

Keywords: virtual reality patient preference
observational study of hiv-infected subjects with x4-tropic or non-phenotypeable virus

Conditions: HIV Infection

Summary: the purpose of this study is to measure viral tropism over time in subjects with x4-tropic or non-phenotypeable virus while receiving standard of care therapy. this is an observational study. no investigational treatment will be administered through this study.


Eligibility criteria:
inclusion criteria: * hiv-infected. * screening viral load at least 5000copies/ml. * x4-tropic only or non-phenotypeable virus at screening. * total prior antiretroviral experience of at least 3 months and documented resistance to at least one drug in each of the following classes: nrti, nnrti, and pi, stable antiretroviral regimen (or no antiretroviral treatment) for at least 4 weeks before screening. * able to receive a ritonavir-boosted protease inhibitor during treatment studies. * women of childbearing potential must use specific forms of contraception. exclusion criteria: * r5-tropic only or r5/x4-tropic virus at screening, changes to antiretroviral therapy from 4 weeks prior to screening until day 1 of observational study. * pregnant or breastfeeding women. * significant ecg abnormalities or significant history of active pancreatitis, hepatitis, opportunistic infections, cancer, or severe illness. * current use of certain medications may exclude participation in this study. * additional qualifying criteria and laboratory test requirements to be determined by study physician.

Keywords: hiv-1 gw873140 ccr5 antagonist experienced treatment experienced
alcohol and health: personalized feedback

Conditions: Alcohol Drinking; Alcohol Consumption, Youth

Summary: heavy episodic drinking (hed) among college students remains a concern within the u.s., as rates of hed are still high in this population. though a variety of brief motivational interventions for alcohol use in college students have demonstrated significant effects, these effects are often small and not consistently maintained over time. personalized feedback interventions (pfis) are a particularly promising approach, as these are often acceptable to college students, as well as low-cost, and easy to disseminate. though presentation of interperson discrepancy via descriptive and injunctive norms has shown consistent effects within pfis and received much attention in the literature, intraperson, or ideal-actual self discrepancies, has largely been ignored. drawing from cognitive dissonance theory, self-regulation theory, and motivational interviewing, the current study aims to evaluate the efficacy of an alcohol pfi with a values component to incorporate ideal-self discrepancy into a typical intervention.


Eligibility criteria:
inclusion criteria: * must be at least 18 years of age * must be able to speak and read english * must report consuming alcohol in a typical week over the past month exclusion criteria: * must not deny drinking within the past month * non-english speaking * under the age of 18