Kornimate/medical-research-clean huggingface dataset:
rehabilitation manometry study

Conditions: Oropharyngeal Dysphagia

Summary: oropharyngeal dysphagia, or difficulty swallowing, is a devastating condition that affects physiological and psychosocial functioning in 1 in 25 adults. many dysphagia treatments exist, but our ability to adequately measure treatment outcomes is limited. pharyngeal high-resolution manometry (phrm) directly measures swallowing pressures, providing an objective measurement of physiology that characterizes the basic mechanisms of swallowing. phrm is well-poised to measure outcomes of dysphagia treatments due to its direct, objective, and reproducible measures of swallowing function. this proposed project will address a central hypotheses that objective swallowing measures (including (phrm) will reveal treatment-mediated swallowing changes, will align with patient-reported outcome measures, and will be able to predict who will benefit from treatment. the investigators will follow a cohort of participants with oropharyngeal dysphagia as they undergo either pharyngeal strengthening therapy or relief of upper esophageal sphincter outlet obstruction at three time points: baseline, mid-treatment (4-6 weeks) and post-treatment (10-12 weeks). the investigators will compare participants to healthy controls using phrm, videofluoroscopy, diet assessment, functional reserve tests, and patient-reported outcome measures.


Eligibility criteria:
inclusion criteria: * pathological group * must have dysphagia as diagnosed by a licensed and certified otolaryngologist, gastroenterologist, or speech-language pathologist and must have a dysphagia treatment plan that includes one of the following primary goals: * therapy to strengthen oropharyngeal musculature * medical or surgical management to relieve an obstruction at the upper esophageal sphincter * must agree to comply with swallowing assessment, including interview and manometry * must sign the informed consent form approved by the health sciences institutional review board of the university of wisconsin * normal group * having no swallowing disorders * must agree to comply with swallowing assessment, including interview and manometry * must sign the informed consent form approved by the health sciences institutional review board of the university of wisconsin.\\ exclusion criteria: * pathological group * therapeutic management plan already initiated prior to recruitment * therapy goals including only improvement of swallowing coordination * developmental disability, dementia, cognitive dysfunction, or difficulty comprehending instructions * positive history of allergic response to topical anesthetic * allergy to food relevant to study participation (e.g. lactose intolerance) * normal group * known swallowing disorder * developmental disability, dementia, cognitive dysfunction, or difficulty comprehending instructions * positive history of allergic response to topical anesthetic * allergy to food relevant to study participation (e.g. lactose intolerance)
a safety and efficacy study of human monoclonal antibodies, brii-196 and brii-198 for the treatment of patients with covid-19

Conditions: COVID-19

Summary: this study is to evaluate the safety, efficacy and pharmacokinetics profile of human monoclonal antibodies, brii-196 and brii-198 compared with placebo in patients with covid-19.


Eligibility criteria:
inclusion criteria: * subject ≥ 18 years, signing the informed consent. * sars-cov-2 infection by pcr ≤ 7 days * one or more of covid-19 related symptoms or measured fever present within 48 hours prior to study entry (subjects with mild-moderate covid-19) exclusion criteria: * recurring covid-19 patients. * subjects with any unstable conditions, a history of significant hypersensitivity, or known allergy to components of the investigational agent * receipt of convalescent covid-19 plasma, sars-cov-2 mab treatment, sars-cov-2 vaccine, or other investigational treatments prior to study entry.

Keywords: covid-19 phase 2 monoclonal antibody
ai-assisted system for accurate diagnosis and prognosis of breast phyllodes tumors

Conditions: Phyllodes Breast Tumor; Artificial Intelligence; Multiomics; Prognostic Cancer Model; Diagnosis

Summary: breast phyllodes tumor (pt) is a rare fibroepithelial tumor, accounting for 1% to 3% of all breast tumors, categorized by the who into benign, borderline, and malignant, based on histopathology features such as tumor border, stromal cellularity, stromal atypia, mitotic activity and stromal overgrowth. malignant pts account for 18%-25%, with high local recurrence (up to 65%) and distant metastasis rates (16%-25%). benign pt could progress to malignancy after multiple recurrences. therefore, early, accurate diagnosis and identification of therapeutic targets are crucial for improving outcomes and survival rates. in recent years, there has been growing interest in the application of artificial intelligence (ai) in medical diagnostics. ai can integrate clinical information, histopathological images, and multi-omics data to assist in pathological and clinical diagnosis, prognosis prediction, and molecular profiling.ai has shown promising results in various areas, including the diagnosis of different cancers such as colorectal cancer, breast cancer, and prostate cancer. however, pt differs from breast cancer in diagnosis and treatment approach. therefore, establishing an ai-based system for the precise diagnosis and prognosis assessment of pt is crucial for personalized medicine. the research team, led by dr. nie yan, is one of the few in guangdong province and even nationally, specializing in pt research. their team has been conducting research on the malignant progression, metastasis mechanisms, and molecular markers for pt. the team has identified key mechanisms, such as fibroblast-to-myofibroblast differentiation, and the role of tumor-associated macrophages in promoting this differentiation. they have also identified molecular markers, including mir-21, α-sma, ccl18, and ccl5, which are more accurate in predicting tumor recurrence risk compared to traditional histopathological grading. the project has collected high-quality data from nearly a thousand breast pt patients, including imaging, histopathology, and survival data, and has performed transcriptome gene sequencing on tissue samples. they aim to build a comprehensive multi-omics database for breast pt and create an ai-based model for early diagnosis and prognosis prediction. this research has the potential to improve the diagnosis and treatment of breast pt, address the disparities in breast pt care across different regions in china, and contribute to the development of new therapeutic targets.


Eligibility criteria:
inclusion criteria: * patients diagnosed with a phyllodes tumor of the breast exclusion criteria: * blurred images, imaging artifacts
utilization of hiv clinical services in rural india

Conditions: HIV Infections; Sexually Transmitted Infections

Summary: this community-based clinical trial based in two districts of rural maharashtra, india compares utilization of an intervention model of "fully-decentralized," or rural primary clinic-based, hiv testing and care services, with a control model of the indian government's partially-decentralized hiv services, offering rural referral clinic testing and urban-based hiv care.

india has one of the highest estimated number of hiv cases globally. sixty percent of its hiv cases occur in rural residents, yet there is no system of hiv testing or care services for them. preliminary studies have identified very low hiv testing utilization among men and recently pregnant women in rural maharashtra, even though these are, by government policy, high-priority target groups for rural hiv testing, diagnosis, and prevention. this study will compare two models of rural hiv testing and care services in two districts of maharashtra, india. the "control" model is the indian government's current strategy of "partially decentralized" rural-based hiv testing services at a secondary-level community health center clinic, which serves a village group population of 30,000. hiv care including antiretroviral therapy is provided a the rural district headquarters in the district urban center. the "intervention" model is a novel model of "fully decentralized" rural-based hiv testing which will be offered at the community health center, two primary health centers, and eight village-level sub-center clinics, and hiv care offered at a rural-based clinic. the primary outcomes of this trial are to assess and compare utilization rates for these two types of hiv services models among rural adult men age 18-49 and pregnant women age 18 and older. additionally, the secondary outcomes include comparing hiv clinical and behavioral risk characteristics of services utilizers in each model, and characteristics of utilizers versus non-utilizers between and within each model. clinical care outcomes include who clinical stage at time of hiv diagnosis and at first clinical care visit, and birth outcomes for hiv-infected pregnant women.

Eligibility criteria:
inclusion criteria: * adult male age 18 - 49 or pregnant female age 18 and older * capacity to give written informed consent exclusion criteria: * refusal, or physical or mental incapacity to give written informed consent

Keywords: hiv/aids voluntary counseling and testing rural india hiv care health services research
transitional telehealth home care: reach

Conditions: Congenital Heart Disease; Post Cardiac Surgery

Summary: the investigators want to determine if additional, increased contact with infants and families discharged to home after cardiac surgery improves infant and parent outcomes as compared to usual care.

the investigators want to compare videoconferencing (skype or factime) and a monitoring system called buddy check is helpful. buddy check is a web-based tool using speech and internet technology to maintain contact with the health care team. infants are randomized to usual care or the intervention which uses automated daily phone calls and 2 virtual home visits each week. weights, oxygen levels, and amount of food taken are obtained by the primary caregiver (parent) daily and sent via automated phone call, text message or email messages based on primary caregiver's desired.

Eligibility criteria:
inclusion criteria: * cardiac surgery within 2.5 weeks of life, * diagnosis of congenital heart disease, * post menstrual age 37 weeks and older; * minimum birth weight 2500 grams, * at least one parent speaks and reads english, * anticipated discharge by 21 days of life exclusion criteria: * cardiomyopathy, * diagnosis of genetic syndrome

Keywords: congenital heart disease neonates and infants telehealth virtual home visits
tenofovir disoproxil fumarate vs. entecavir in chronic hepatitis b patients with partial virologic response to entecavir

Conditions: Chronic Hepatitis B

Summary: entecavir, a potent antiviral agent, has been widely used for treatment-naïve chronic hepatitis b patients. however, about 20% of patients showed partial virologic response after 2 year of entecavir therapy (33% in hbeag positive, 10% in hbeag negative patients). tenofovir is a nucleotide analogue with more potent antiviral activity. in addition, there is no cross resistance between the two drugs. therefore it is assumed that tenofovir would be effective in the treatment of chronic hepatitis b patients who shows partial virologic response (detectable hbv dna by real time pcr after 12 months of treatment) despite treatment with entecavir. in this study, we will compare the efficacy of switching to tenofovir with continuing entecavir in patients who shows partial virologic response to entecavir.

the number of patients needed was calculated using pass 2008. we hypothesized that two-thirds (65%) of the patients receiving tdf, and one-fifth (20%) of the patients receiving etv, would achieve virologic response. we also assumed a 15% drop-out rate; thus, 22 patients were needed in each group to achieve 80% power to demonstrate a difference between the groups with a 5% level of significance. the primary efficacy end point will be analyzed on a per-protocol basis, including only those patients who had completed the treatment schedule of study. in contrast, the intention-to-treat analysis will include all randomized subjects, even those dropped-out from the study before 12 months, as cases of treatment failure.

Eligibility criteria:
inclusion criteria: 1. chb patients (positive hbsag more than 6 months) 2. age 19 years old 3. hbeag positive or negative patients 4. patients receiving entecavir 0.5 mg more than 12 months 5. detectable hbv dna by real time pcr (hbv \> 60 iu/ml) 6. compensated liver function (child-pugh-turcotte score ≤7, prothrombin time 3 sec above uln or inr ≤1.5, serum albumin \>3 g/dl, total bilirubin \<2.5 mg/dl, no history of variceal bleeding, diuretics or ascites requiring paracentesis, hepatic encephalopathy) exclusion criteria: 1. history of treatment with nucleotide analogue other than 0.5 mg of etv 2. serum creatinine level \> 1.5 mg/dl or creatinine clearance \< 50 ml/min 3. absolute neutrophil count ≤ 1000 cell/ml 4. hemoglobin level ≤ 10 g/dl in men or ≤ 9 g/dl in women 5. antiviral resistance mutations on rtt184, rts202, or rtm250 + rtm204v/i 6. a positive antibody test for human immunodeficiency virus, hepatitis c virus, or hepatitis d virus 7. pregnancy or lactation 8. hcc (in cases where alfa-fetoprotein levels were over 100 ng/ml, abdominal computed tomography or magnetic resonance image was performed to exclude hcc) 9. untreated malignancy other than hcc.

Keywords: chronic hepatitis b tenofovir entecavir partial responder
dance as a means to improve functions and quality of life after a stroke

Conditions: Stroke

Summary: context dance is an intrinsically motivating activity comprising social interaction, stimulation through music, the joy of moving despite motor limitations induced by pathology, and which has good perceived benefits among participants. moving with pleasure is essential to finding the motivation to engage in rehabilitation program and physical activity. in stroke context, physical activity and rehabilitation were difficult to carry out because of cognitive and motor disabilities. moreover, when the rehabilitation is over, the diminishing motor stimulation gradually limits autonomy in daily tasks. it is therefore urgent to provide persons in a post-stroke situation with motivating physical activity opportunities. very few studies have studied dance in a context of stroke, while this physical activity is highly adapted and effective for other chronic conditions. objectives: the main objective is to assess the effects of dance practice on cognitive and motor functions for persons after stroke. the secondary objective is to investigate the effects of dance on quality of life, motivation and adherence. the investigator's hypothesis is that the practice of dance induces an increase of balance and motor capacities, and improving the quality of life, adherence and motivation after a stroke. materials and method : forty-eight subjects with stroke in subacute phase will be randomized into two groups: 1) intervention (dance and standard rehabilitation) and 2) control (standard rehabilitation). before intervention, stroke severity, cognitive abilities and motor capacities will be tested. two baseline tests will occur to assess the stability of individuals will be planned. participants will attend a dance class weekly during 6 weeks. the cognitive and motor functions (balance, lower-limbs strength, coordination and motor level), the quality of life (stroke-specific quality of life scale) will be measured at 4 and 6 weeks in both groups. participant satisfaction with regard to dance will be tested, as well as adherence and adverse effects. perspectives: the joy of dancing and the possibility of including other non-disabled people should facilitate adherence and motivation and increase the recovery of cognitive and motor functions.this project should motivate physiotherapists and dance teachers to increase the offer of dance classes for persons with motor and cognitive impairments.this action will be a basis for combating people's sedentary lifestyle after a stroke.


Eligibility criteria:
inclusion criteria: * post stroke * subacute phase * able to endure 60 minutes of physical activity * medical stability * able to understand the consign exclusion criteria: * medical complications * hearing disorders * previous pathologies associated with balance disorders

Keywords: stroke rehabilitation dance
the effect of virtual reality and music recital on anxiety and agitation in patients undergoing spinal anaesthesia

Conditions: Spinal Anaesthesia; Anxiety State; Surgery; Ajitation

Summary: this study will be carried out in patients undergoing spinal anaesthesia. the effects of virtual reality and music playback on anxiety and agitation in patients will be evaluated.

virtual reality is a computer technology in which a virtual environment is simulated in three dimensions. this technology isolates the individual from real life by zooming the lenses to the patient's eyes through a headset known as virtual reality glasses. recently, with technological developments, virtual reality applications have started to take place among nursing practices as non-pharmacological approaches that support pharmacological methods in clinical settings. various studies have revealed that virtual reality as a distraction method plays an important role in alleviating anxiety and agitation experienced by patients. music application is an easy-to-apply and non-invasive non-pharmacological method. music recitals give a feeling of relaxation by increasing the release of endorphin hormone in individuals and play an important role as a psychosocial intervention. such activities reduce symptoms of anxiety and depression, improve quality of life and have positive effects on physical symptoms and general well-being. in addition, the effects of music on respiratory rate, blood pressure and heart rate are also observed. this study aims to evaluate the effects of virtual reality technology and music playback on anxiety, agitation and physiological parameters in patients undergoing spinal anaesthesia and to make important contributions to the literature in this context.

Eligibility criteria:
inclusion criteria: * 18 years of age or older, * clear consciousness, able to communicate, * no hearing-speech problems, * who volunteered to participate in the study, * patients who would undergo urology, general surgery, orthopedics, cardiovascular surgery, neurosurgery by spinal anaesthesia were included in the study. exclusion criteria: * patients without spinal anaesthesia, * patients who participated in the study but voluntarily withdrew at any stage of the study or patients who had to withdraw involuntarily during the operation were not included in the study.

Keywords: spinal anaesthesia anxiety patient
permanent occlusion of uteine arteies in management of abnormal uterine bleeding

Conditions: Other Abnormal Uterine and Vaginal Bleeding

Summary: prospective observational interventional study , the study done in two phases: 1. phase one from october 2011to may 2012 pilot study including twenty nine (29) premenopausal patients followed up for six months 2. phase two from october 2012 till may 2014. including eighty nine (89) premenopausal patients all of them needing to preserve their uteri.

abstract objectives: to assess the effectiveness of permanent bilateral occlusion of uterine arteries in treatment of abnormal uterine bleeding. design: prospective observational study setting: done in mansoura university hospital, department of obstetrics and gynecology. patients and methods: the study done in two phases: 1. phase one from october 2011to may 2012 pilot study including twenty nine (29) premenopausal patients followed up for six months 2. phase two from october 2012 till may 2014. including eighty nine (89) premenopausal patients all of them needing to preserve their uteri. results: results are hopeful and courageous in phase one as regards patients satisfaction, quality of life and improvements of bleeding. results of phase two will be implemented, analyzed and presented in tables. all data will be statistically analyzed and the results will be presented after completion of eighteen (18) months follow up to rule out any bias and/ or errors in the results. conclusion: permanent bilateral uterine arteries occlusion may be a good alternative to radical surgery in abnormal uterine bleeding.

Eligibility criteria:
inclusion criteria: * premenopausal with abnormal uterine bleeding and completed their families having normal endometrium (biopsy in preceding 6 months ) and may have uterine intramural myomas not exceeding 150 ml in volume and away from uterine cavity by at least 1cm and /or adenomyosis exclusion criteria: * patients wishing future fertility * endometrial sampling not done or more than 6 months or myoma encroaching or distorting cavity or larger than 150 ml in volume

Keywords: permenant occlusion uterine bleeding uterine arteries
structured exercise prescription program in obese children

Conditions: Obesity; Exercise; Cardiovascular Risk Factor; Liver Diseases; Metabolic Syndrome; Childhood Obesity

Summary: this controlled clinical trial aims to compare the effects of a multicomponent program that includes structured personalized exercise prescription in children with obesity with a control group that will be enrolled in a multicomponent program without structured personalized exercise prescription. all children will be followed for a period of 6 months. the parameters that will be evaluated between groups are physical fitness, anthropometry, metabolic (glucose oral tolerance curve, lipids, homa-ir, isi-matsuda), early cardiovascular damage, inflammatory biomarkers, anxiety and depression scores, and allelic variants related to physical fitness.

this controlled clinical trial aims to compare the effects of a multicomponent program that includes structured personalized exercise prescription in children with obesity (study group) with a control group that will be enrolled in a multicomponent program without structured personalized exercise prescription. all children will be followed for a period of 6 months. the parameters that will be evaluated between groups are physical fitness (measured by vo2max, ecg at rest, biomechanics and dynamometry), anthropometric measurements (weight height, bmi, plicometry, bioimpedance, metabolic (glucose oral tolerance curve, lipids, homa-ir, isi-matsuda), early cardiovascular damage (carotid intima-media thickness, atherogenic dyslipidemia), inflammatory biomarkers (leptin, adiponectin, il-17, il-10, inf-gamma, il-6, il-12, y tnf-alpha), anxiety and depression scores evaluated with child depression inventory (cid) and -trait anxiety inventory for children (stai-ch), and allelic variants related to physical fitness (actn, trh2 y fto).

Eligibility criteria:
inclusion criteria: patients with bmi ≥ pc 95 and \< 35kg/m2 both sexes accepts to participate and signs informed consent exclusion criteria: presence of endocrine disease including type i and ii diabetes mellitus presence of arterial hypertension presence of primary dyslipidemia presence of infections at moment of enrollment presence of systemic disease presence of genetic disorder medical treatment that may interfere with lipid or glucose metabolism prolonged or acute immobilization participated in a previous similar intervention

Keywords: obesity children non-alcoholic fatty acid liver disease exercise metabolic syndrome cardiovascular risk