Kornimate/medical-research-clean huggingface dataset:
clinical, biochemical, histological and biophysical parameters in the prediction of cerebral palsy in patients with preterm labor and premature rupture of membranes

Conditions: Preterm Birth; Pregnancy

Summary: a major goal of modern perinatal and neonatal medicine is to reduce the rate of developmental disabilities, especially mental retardation. cerebral palsy is frequently associated with neurologic abnormalities and mental retardation. improvements in neonatal intensive care have resulted in improved survival of very low birthweight infants but also in an increased frequency of cerebral palsy. prematurity is a leading risk factor for cerebral palsy. two thirds of preterm neonates are born to mothers with preterm labor with intact membranes or preterm premature rupture of membranes. a growing body of evidence suggests that these conditions are heterogeneous. this is an observational cohort study designed to identify the mechanisms of disease in patients with preterm labor/contractions and preterm premature rupture of membranes and to describe the relationship between clinical, biochemical, histological, biophysical parameters and the development of infant neurological disorders.

a major goal of modern perinatal and neonatal medicine is to reduce the rate of developmental disabilities, especially mental retardation. cerebral palsy is frequently associated with neurologic abnormalities and mental retardation. improvements in neonatal intensive care have resulted in improved survival of very low birthweight infants but also in an increased frequency of cerebral palsy. prematurity is a leading risk factor for cerebral palsy. two thirds of preterm neonates are born to mothers with preterm labor with intact membranes or preterm premature rupture of membranes. a growing body of evidence suggests that these conditions are heterogeneous. this is an observational cohort study designed to identify the mechanisms of disease in patients with preterm labor/contractions and preterm premature rupture of membranes and to describe the relationship between clinical, biochemical, histological, biophysical parameters and the development of infant neurological disorders.

Eligibility criteria:
* inclusion criteria: consecutive patients admitted with the diagnosis of preterm labor/contractions or prom. "preterm labor/contractions" will be defined as: 1. gestational age: 20-36 weeks; 2. intact membranes; and 3. regular uterine contractions greater than or equal to 8 in 60 minutes. preterm prom will be defined as: 1. gestational age 20-36 weeks; and 2. spontaneous rupture of membranes as diagnosed by sterile speculum examination confirming pooling of amniotic fluid in the vagina, a positive nitrazine test result, and a positive ferning test result. in cases of suspected but unconfirmed preterm prom, indigo carmin instillation will be performed. the vaginal leakage of indigo carmin will confirm the diagnosis in these cases.

Keywords: pregnancy pregnancy complications natural history
ultrasound guided bilateral erector spinae plane block in laparoscopic cholecystectomy

Conditions: Postoperative Pain

Summary: this study will define the postoperative analgesic effect of esp block via amount of patient-controlled analgesia (pca) and postoperative analgesic consumption (such as routinely and rescue analgesics) and compare the control group in patients having laparoscopic cholecystectomy .

laparoscopic interventions are considered as minimally invasive procedures. they have both cosmetic and open surgery advantages in terms of surgical stress. laparoscopic cholecystectomy is the most commonly performed laparoscopic upper abdominal procedure. after this procedure, patients often complain of excessive pain. non-steroidal anti-inflammatory agents and opioids are used for postoperative analgesia. in addition, in the past decade, in the guideline of ultrasonography, peripheral block types with analgesic activity have been described in laparoscopic cholecystectomies as well as in many operations on the development of regional anesthesia and analgesia techniques. it was reported that transverse abdominis plane (tap) block provided effective analgesia in these cases in the first ultrasonography guideline of petit triangle region in 2010. later studies on tap block activity, drug doses and concentrations in laparoscopic cholecystectomies have been conducted. there are also publications indicating that tap block has been applied to the subcostal region for more effective analgesia. the esp block is a new block for the treatment of thoracic neuropathic pain. in the following process; esp block thoracic and breast surgery, bariatric surgery, and upper abdominal surgeons have also been reported to provide effective postoperative analgesia . the standard practice for post-operative pain management for laparoscopic cholecystectomy in maltepe university hospital consists of routine intravenous analgesic and rescue analgesics and in combination with patient-controlled analgesia (pca). given the importance of providing adequate analgesia in upper abdomen surgery and lack of consensus amongst surgeons and anesthesiologists for the optimal analgesic technique, the investigators are proposing a prospective observational study to examine the analgesic efficacy of the esp block in laparoscopic cholecystectomy as a potential analgesic technique. the investigators are hoping the results of this study will provide framework for future larger comparative studies.

Eligibility criteria:
inclusion criteria: * elective laparoscopic cholecystectomy, asa status 1-2 exclusion criteria: * patient refusal * contraindications to regional anesthesia * known allergy to local anesthetics * bleeding diathesis * use of any anti-coagulants * inability to provide informed consent * severe kidney or liver disease * inability to operate pca system * patient with psychiatric disorders
effect of single-dose dexmedetomidine on emergence excitement in adults with nasotracheal intubation after orthognathic surgery

Conditions: Agitation

Summary: excitement during the emergence from general anesthesia is a great post-operative problem. it may lead to serious consequences for the patient, such as injury, increased pain, hemorrhage, self-extubation, and removal of catheters, and it can necessitate physically or chemically restraining the patient. it has been reported that the incidence of postoperative emergence excitement in adults after general anesthesia is 21.3% occurrence. many things are mentioned as risk factors for emergence excitement. among them, excitement after orthognathic surgery (two-jaw) was more common than after other types of surgery. the patients undergoing emergence with nasotracheal intubation after orthognathic surgery may have a sense of suffocation during emergence from anesthesia, which may increase the incidence of emergence excitement. pain is also a main cause of postoperative excitement. dexmedetomidine, which is an s-enantiomer of medetomidine with high specificity for α2-adrenoceptor (α2 : α1, 1620 : 1) compared to clonidine (a2 : a1, 220 : 1), is approved as a sedative and co-analgesic drug. to the best of the investigators knowledge, effect of dexmedetomidine on emergence excitement was investigated only in children. the investigators hypothesized that single dose of dexmedetomidine would reduce the incidence and the severity of the emergence excitement in adults with nasotracheal intubation after orthognathic surgery (two-jaw).


Eligibility criteria:
inclusion criteria: * asa physical status 1 or 2 patients * patients scheduled for orthognathic surgery (two-jaw) exclusion criteria: * severe cardiovascular disease * allergy to dexmedetomidine * psychological disease * patients who cannot understand korean
weekly topotecan in patients treated for metastatic colorectal cancer

Conditions: Colon Cancer

Summary: this non-randomized phase ii study is designed to assess the response rate and toxicity of weekly topotecan as second-line treatment in patients with relapsed or refractory metastatic colorectal cancer.

upon determination of eligibility, patients will be receive: * topotecan

Eligibility criteria:
inclusion criteria: to be included in this study, you must meet the following criteria: * metastatic colorectal cancer * one previous chemotherapy for metastatic disease * measurable or evaluable disease * able to perform activities of daily living with assistance * adequate bone marrow, liver, and kidney function * all patients must give written informed consent prior to study entry. exclusion criteria: you cannot participate in this study if any of the following apply to you: * brain or meningeal involvement * serious active infection or underlying medical conditions * other active neoplasms are ineligible * pregnant or lactating please note: there are additional inclusion/exclusion criteria. the study center will determine if you meet all of the criteria. if you do not qualify for the trial, study personnel will explain the reasons. if you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
prevention of hpv in the school health service

Conditions: Human Papillomavirus; Cervix Cancer

Summary: the last ten years sexually transmitted infections (sti) have substantially increased among adolescents. sti can lead to individual suffering and have a negative effect on the future reproductive health and also increase the need for health care, thus it is important to reduce the number of stis. hpv vaccination is included in the school-based vaccination program since 2012, a catch-up vaccination is offered to older girls and young women aged 13-25. school nurses have a key role regarding information about hpv and hpv vaccine, and the school-based vaccination program has a substantial higher coverage rate. knowledge is an important factor associated with attitude to preventive methods against hpv. in previous studies the results indicate that young people have low awareness of hpv and the hpv vaccine. interventions can decrease sexual risk taking and influence the intention to receive hpv vaccination and increase the use of condom. the aim of this study is to increase primary prevention of human papillomavirus (hpv) by promoting hpv vaccination and increase condom use among upper secondary students. the aim is also to increase the knowledge about hpv, risk and prevention.


Eligibility criteria:
inclusion criteria: * first year students in upper secondary school who visit the school nurse for the regular health interview. * master swedish in speech and writing. exclusion criteria: * students with cognitive disabilities.

Keywords: adolescent attitude condom human papillomavirus vaccines primary prevention school health
axial length with adult onset myopia (alwaom)

Conditions: Myopia

Summary: purpose: to determine axial length progression and its relationship with myopia onset and progression in adults.

objectives 1. determine axial length progression over a two year period of at least 100 subjects/students aged 21 or over (subjects may come from multiple sites). subjects are to be chosen from optometric education programs beginning in the student's first year. 2. determine correlation of axial length changes to refractive changes over the two year period. 3. obtain results of orthokeratology and its effect on axial length and refractive changes. methods 1. measurements of axial length with optical biometry will be taken at yearly intervals for three years and recorded on a spreadsheet (see attached) for future data analysis. effort will be made to perform measurements at approximately same date each year. 2. refractive error will be measured using a consistent method such as an autorefractor at yearly intervals for three years and recorded on same spreadsheet as axial length for future data analysis. effort will be made to perform measurements at approximately same date each year. 3. subjects that are fit into orthokeratology will be fit with the moonlens design (provided by art optical at no charge) per normal fitting protocol and followed up with normal protocol axial length will be measured pre-fitting and at least every year for the three year period. topography will be captured at pre-fitting and post fitting per normal protocol with images taken at least once per year for three year period. refraction will also be conducted at least once per year. axial length and refraction data are to be recorded on same spreadsheet as above and topography saved to a separate folder for future analysis.

Eligibility criteria:
inclusion criteria: 1. 1st year optometry student 2. refractive error - spherical component: +2.00d to -5.00d; astigmatic component: up to -1.50d; non-presbyopic 3. not currently using any treatment for myopia control, including orthokeratology lenses, soft multifocal lenses, misight lenses, pharmacological interventions, or spectacles for myopia control 4. no significant anterior or posterior segment disease exclusion criteria: 1. non-graduate student 2. refractive error outside of: +2.00d to -5.00d; astigmatic component: up to -1.50d; presbyopic 3. any participants using treatment for myopia control, including orthokeratology lenses, soft multifocal lenses, misight lenses, pharmacological interventions, or spectacles for myopia control 4. significant anterior or posterior segment disease 5. pregnancy 6. significant systemic disease that may affect refractive error (i.e. diabetes)

Keywords: axial length myopia
docetaxel versus oxaliplatin as addition to s-1 for stage ii / iii gastric adenocarcinoma

Conditions: Gastric Cancer

Summary: s-1 plus oxaliplatin has been proved better than s-1 alone for stage ii or iii gastric cancer. docetaxel also showed excellent efficacy with s-1 in the postoperative setting for stage iii gastric cancer. this trial is designed to investigate the efficacy and safety of s-1 plus docetaxel versus s-1 plus oxalipltin as adjuvant chemotherapy after d2 resection in stage ii / iii gastric cancer.

in this study, patients with gastric or egj adenocarcinoma who received d2 dissection and staged ii or iii, aged from 18 to 75 years and with ecog ps ≤2 and adequate organ function, are stratified randomized according to pstage and location of primary lesion. group ds: s-1 is orally administer by bsa (\ 1.5m2,120 mg) divided into two doses a day after breakfast and dinner for 14 days every three weeks to a total of 16 cycles postoperatively. docetaxel 40mg/m2/3w from the second to the seventh cycles. group sox: s-1 is orally administer by bsa (\ 1.5m2,120 mg) divided into two doses a day after breakfast and dinner for 14 days every three weeks to a total of 16 cycles postoperatively. oxaliplatin 130mg/m2/3w from the first to the eight cycles. the primary end point is disease-free survival(dfs). the overall survival (os), safty and quality of life are secondary end points.

Eligibility criteria:
inclusion criteria: * informed consensus of patients * be able to receive oral administration * from 18 to 75 years old * be proven to be primary adenocarcinoma of stomach and staged ii or iii by pathological evidences * without other chemotherapy and/or radiation against to the disease * normal function of other organs including heart,liver ,kidney and so on * eastern cooperative oncology group performance status:0\~2 exclusion criteria: * history of other malignancy * allergic reaction to s-1 or oxaliplatin of docetaxel * be enrolling in other clinical trials * abnormal gi tract function * dysfunction of other organs * female in pregnancy or lactation,or refuse to receive contraception measures during chemotherapy * other situation to be judged not adaptive to the study by investigators
gut-brain-axis/lung-brain-axis and mental ill health in critical illness

Conditions: Mental Health Issue; Critical Illness; Gut Microbiome

Summary: survivors of critical illness commonly experience long-lasting cognitive, mental health and physical impairments. clinically significant symptoms of anxiety, depression, and post-traumatic stress disorder (ptsd) may occur in 40%, 34% and 20% of icu survivors respectively, compared to 6%, 8% and 4% in the general population. these symptoms can persist for more than 8 years. evidence shows the existence of a two-way, communication network between gut microbes and the brain referred to as the gut-brain axis. changes in the microbiome and dysregulation of this communication network in relatively healthy people is associated with cognitive dysfunction and mood disorders such as anxiety and depression. the physiological stress associated with critical illness itself and many icu interventions including the use of mechanical ventilation and medications such as antibiotics, antacids, vasopressors, and steroids can influence the balance of the gut microbiome and associated metabolites. this observation study aims to: 1. quantify and measure dynamic changes in the gut microbiome and its metabolites during critical illness and recovery. 2. explore the associations between microbiome and metabolomic changes during critical illness and psychological symptoms in the patient during their recovery. this knowledge will provide the potential to create interventions that alter the gut environment and microbiome both during and following a critical illness in order to reduce long-term adverse psychological effects. examples of such potential interventions include dietary modifications with the use of prebiotics or probiotics.


Eligibility criteria:
inclusion criteria: * unplanned admission to critical care * aged ≥18 years old * requiring mechanical ventilation * commencing ventilation within the previous 24 hours * expected to be ventilated for minimum of ≥72 hours exclusion criteria: * known prior diagnosis of cognitive impairment * known prior mental ill health * known malignancy * admitted after presenting with any of the following conditions: * trauma * brain injury * surgery * cardiac arrest * immunosuppressed * underlying pyogenic infection * not expected to survive to completion of the study
caregiver burden in stroke: robot-assisted therapy vs conventional rehabilitation

Conditions: Stroke Rehabilitation and Caregivers

Summary: caregiver's burden in rehabilitation is important for both patients physical and mental health. therefore researching caregivers burden and treatment of any depression or associated any psychological disorders of caregiver is crucial.


Eligibility criteria:
inclusion criteria: * hemiplegia after stoke, brunnstrom stages: stage 2-3 of lower limb minimum 6 months after stroke, exclusion criteria: * more than 1 stroke, aphasia, dysphagia, other life life threatening diseases independent ambulation

Keywords: caregivers exoskeleton device stroke rehabilitation
efficacy of autologous epidermal cell suspension and silver sulfadiazine ointment in burn

Conditions: Burn

Summary: different medical treatments are available for treatment of skin burns such as skin grafts and silver sulfadiazine ointment. these treatments are used for second degree burn as routine technique in burns units. cell therapy is a new approach for treatment of skin disease.in this study we use autologous epidermal cell suspension to achieve better cosmetic and functional results in treatment of second degree burn.

in this study 20 patients in burn department of sina hospital tabriz, with at least 2 areas of second degree burn randomly choose. first skin samples are taken from normal skin by 4mm punch and send to the laboratory for preparation of epidermal cell suspension and this suspension is transferred to the one area of second degree burn in each patient and the other area in the same patient dresses by silver sulfadiazine ointment. the dressing changes are followed up for 12h for first assessment of therapy until 10th day after intervention. in the days of 5, 10, 15 and 20 the percentage of re-epithelization for each treatment will be measured. after 2 months, patients are visited and any complications check for scar formation, pain, post inflammatory hyper-pigmentation.

Eligibility criteria:
inclusion criteria: * healthy patient with second degree burn admitted in burn unit exclusion criteria: * pregnancy-lactation * immunosuppression like receiving chemotherapy or radiotherapy * patient unsatisfied to going on study

Keywords: burn epidermal cell suspension
exercise program of breast cancer patients undergoing chemotherapy with or without radiation

Conditions: Breast Cancer

Summary: the purpose of this study is to study if a patients follows an exercise program specifically designed for them during the time of their treatment after surgery. their ability to follow the program and its influence on their weight maintenance and early post-operative lymphedema rates will also be studied. lymphedema is a condition in which excess fluid collects in tissue and causes swelling of the arm(s).


Eligibility criteria:
inclusion criteria: * patients will be eligible if they have any of the following surgical procedures performed by an attending on the breast service: slnb alone axillary lymph node dissection (alnd) alone total mastectomy tm (+/- reconstruction) with slnb or alnd breast conserving therapy (bct) with slnb or alnd * age \> 18 years * planned to undergo adjuvant post-operative chemotherapy with or without radiation at mskcc and have not yet started chemotherapy exclusion criteria: * undergoing tm or bct without slnb * having had prior breast cancer treated with surgery * unable to participate in a exercise program related to other medical problems * more than 8 weeks post surgery. * having a concurrent cancer in addition to breast cancer * who have had any type of chemotherapy in the past two years

Keywords: exercise lymphedema post-operative chemotherapy post-operative radiation 10-062