Kornimate/medical-research-clean huggingface dataset:
microfracture in rotator cuff injury repair

Conditions: Rupture of the Rotator Cuff

Summary: the hypothesis is that microfractures in the footprint of the humerus will aid to improve the tendon healing to the bone. the aim of the study is to investigate whether the use of microfractures at the footprint of the rotator cuff will improve the tendon healing when reinserted. patients undergoing surgery for a rotator cuff injury will be randomised to repair with or without microfracture.


Eligibility criteria:
inclusion criteria: - patients over the age of 18 with a full thickness rotatorcuff rupture. exclusion criteria: * isolated rupture of the subscapularis * tendon atrophia * goutallier grade 3-4 fatty degeneration * fracture surgery in same shoulder * inflammatory or neurologic affection of shoulder * other disabling disease * unwilling to participate in study

Keywords: rotator cuff injury repair microfracture healing
safety and efficacy of bridging antithrombotic therapy during elective non-cardiac surgery

Conditions: Coronary Artery Disease

Summary: patients with coronary artery disease, especially after pci, require long-term oral antiplatelet therapy. however, this patient population may inevitably require non-cardiac surgery for a variety of conditions. in order to avoid the occurrence of bleeding events, oral antiplatelet agents are usually discontinued before non-cardiac surgery in patients with coronary artery disease, which may increase the incidence of ischemic events. therefore, it is important to provide patients with the optimal perioperative antithrombotic treatment to balance the risk of bleeding and ischemia.


Eligibility criteria:
inclusion criteria: 1. aged 18 years or over 2. established coronary artery disease being treated with oral antiplatelet therapy 3. non-cardiac surgery is planned and bridging antithrombotic therapy is considered necessary 4. agree to participate in the study and provide written informed consent exclusion criteria: 1. according to the consensus of chinese experts on antiplatelet therapy in 2013, the surgical bleeding risk is low or extremely low 2. requiring emergency non-cardiac surgery within 24 hours after admission 3. currently being bleeding 4. moderate or severe ischemic stroke or spontaneous intracranial hemorrhage in the past 6 months or traumatic intracranial hemorrhage in the past 1 year 5. intracranial diseases or hemorrhagic diathesis 6. contraindications for lmwh or gp iib/iiia receptor antagonists

Keywords: bridging antithrombotic therapy non-cardiac surgery coronary artery disease
psychometric validation of the hemophilia functional ability scoring tool (hemo-fast)

Conditions: Hemophilia A; Hemophilia B

Summary: the purpose of this study is to validate the newly developed hemophilia functional ability scoring tool (hemo-fast), which is a fast and simple scoring in haemophilia able to assess patient-reported functional mobility.

the purpose of this study is to validate the newly developed hemophilia functional ability scoring tool (hemo-fast), which is a fast and simple scoring in haemophilia able to assess patient-reported functional mobility for adult haemophilia patients.

Eligibility criteria:
inclusion criteria:a patient must fulfil the following criteria in order to be included in the study: 1. age ≥18 years. 2. diagnosis of haemophilia a or b. 3. capable of completing the study patient-reported outcome (pro) questionnaires in french. 4. signed informed consent. exclusion criteria: the presence of any of the following criteria will exclude a patient from inclusion in the study: 1. joint replacement within last 6 months. 2. patients with a non-resolved joint or muscle bleeding event at the enrolment visit or ≤ 7 days prior to the enrolment visit. 3. patients with comorbid illnesses such as juvenile arthritis, muscular dystrophy, neurologic illness/cognitive impairment, or other illnesses that may independently affect hjhs and hemo-fast scores and/or limit the ability of the patient to participate in the study as determined by the investigator.
epidural vs. wound catheter following liver resection

Conditions: Transplant Surgery

Summary: good postoperative pain control after any major surgery allows early mobilization, minimises postoperative complications and reduces patient distress. multiple different methods of delivering analgesia have been described. this study aims to compare postoperative pain control between patients with epidural analgesia versus the combination of continuous infiltration of local anaesthetic with wound catheters, tap block and iv pca with opiate analgesia following open liver resection. the investigators expect that pain control will be similar between the two groups but that the utilization of wound catheters will confer benefit due to the lack of systemic side effects associated with epidural analgesia


Eligibility criteria:
inclusion criteria: * all adult patients scheduled to undergo an open liver resection at this hospital will be eligible to participate. exclusion criteria: * patients with a contraindication to either epidural or wound catheter * inability to give written, informed consent * aged less than 18 years old * liver resection combined with a secondary surgical procedure * body mass index of \ 40 * pregnancy or lactation * a history of chronic pain requiring regular opioid analgesia * prisoners
chinese herbal medicine for dialysis-related myofascial pain: study protocol for a pilot randomized study

Conditions: Myofascial Pain Syndrome

Summary: dialysis-related myofascial pain in hemodialysis (hd) patients is an important issue that is associated with many other psychosomatic problems. effective interventions are required to alleviate pain problems in this group. chinese herbal medicine (chm) has been tried as a potential therapeutic method to improve pain. the aim of this study is to evaluate the effect of a chm formula intervention on pain intensity, daily function, and quality of life, and safety among hd patients in dialysis center within a southern taiwan context.


Eligibility criteria:
inclusion criteria: * adults (aged ≥ 20 y) undergoing conventional hd three times a week via an av fistula; * to have myofascial trigger points (mtrps) in one or more of the following muscles around the av fistula: the flexor carpi radialis, palmaris longus, the pronator teres, the palmaris longus, and/or the finger flexor, diagnosed by dialysis-related myofascial pain, which must be experiencing pain during hd \[m1\]; * onset of symptoms within 1 month before enrollment; * capable of giving adequate response to pain; * have an exquisite tenderness was found on palpation in the taut band with moderate intensity of pain at baseline (ie, a pain score \> 3 on a numeric rating scale); * can commit to not change their medication and dialytic method during the 10 weeks of this study. exclusion criteria: * severe chronic or acute disease interfering with attendance for therapy; * have comorbid conditions such as rheumatoid arthritis, stroke, tumor, coagulopathy, chronic liver disease, radiculopathies of the upper limb, recent history of cervical/shoulder/arm surgery, or trauma; * have depression and/or presence of a psychiatric disorder; * have taken painkillers, muscle relaxant, and anti-inflammatory medications or used topical anesthetics in the past week; * have allergy to chinese herbal product; * unable to understand or sign an informed consent form.
lumbar stabilization, strengthening and stretching in chronic low back pain

Conditions: Chronic Low Back Pain

Summary: the purpose of this study was to compare the efficacy of three exercise programs in patients with chronic low back pain: segmental stabilization, superficial strengthening and stretching. groups were contrasted regarding pain, functional disability and tra muscle activation capacity. the three groups of exercise improved pain and functional disabilities, and the segmental stabilization group was better in the ability to recruit tra muscle.

objective: to contrast the efficacy of three exercise programs, segmental stabilization and strengthening of abdominal and trunk muscle and lumbar stretching on pain, functional impairment, and activation of the transversus abdominis muscle (tra), in individuals with chronic low back pain. design: forty-five patients were randomized into three groups namely: segmental stabilization group (es)(transversus abdominis and lumbar multifidus) (n=15, mean age 42,02 ± 8,15), superficial strengthening group (fs)(rectus abdominis, oblique abdominal muscles and erector spinae muscles) (n=15, mean age 41,71±6,41) and stretching group (al) (erector spinae, posterior connective tissues and ischiotibials muscles) (n=15 mean age 41,53 ± 4,41). groups were contrasted regarding pain (visual analogical scale and mcgill pain questionnaire), functional disability (oswestry disability questionnaire) and tra muscle activation capacity (pressure biofeedback unit = pbu). the program lasted 6 weeks, and sessions happened twice a week, with duration of 30 minutes each. analysis of variance was used for inter and intragroup comparisons. significance level was established at 5%. patients attended two weekly sessions during six weeks and were evaluated for pain (visual analogue scale and mcgill pain questionnaire), functional disability (oswestry disability index), and ability to contract the tra (pressure biofeedback unit) before and after the treatment. the treatment program consisted of 30 minutes sessions. the anova one-way and tukey´s post hoc were used to compare groups. the significance level adopted was 5%.

Eligibility criteria:
inclusion criteria: * low back pain for more than 3 months * patients willing to participate and could participate in an exercise program safely and without cognitive impairments that would limit their participation. exclusion criteria: * past history of back surgery * rheumatologic disorders * spine infections * spine exercise training in the 3 months before study onset.

Keywords: low back pain clinical trial stabilization muscle stretching exercises exercise therapy
an observational study to evaluate cardiovascular outcomes of t2dm patientstreated with gemigliptin

Conditions: Type 2 Diabetes Mellitus

Summary: the primary objective of the study is to investigate cardiovascular safety of gemigliptin by evaluating the time until patients report with major adverse cardiovascular events (mace) in t2dm patients treated with gemigliptin. study patients will be followed up to 4 years until mace occurrence or until the patient drops out of the study or completion of the study. the patient who switches to a non-gemigliptin treatment after initiating gemigliptin therapy will be followed until mace occurrence or until the patient drops out of the study or completion of the study. the secondary objectives of the study are to evaluate adverse events related as well as not-related to mace in diabetic patients treated with gemigliptin.


Eligibility criteria:
inclusion criteria: * female or male patients, who are ≥ 19 years, with diagnosis of t2dm * diabetic patients whose condition cannot be adequately controlled by on-going dietary and/or under antidibatetic treatment are decided to prescribe gemigliptin according to the physician's judgment * patients must be willing and able to provide written informed consent form to use of personal information as well as the guardian's contact information and the permission to contact with the guardian in case the patient cannot be contacted. exclusion criteria: * patients with t1dm * patients who experienced an acute coronary syndrome (st-elevation myocardial infarction and non- st elevation myocardial infarction) or ischemic stroke within the last 3 months before enrolment or patients who have been treated with dipeptidyl peptidase iv (dpp-4) inhibitors or glucagon-like peptide (glp-1) analogues for 3 months before enrolment. * patients with a diagnosis of severe or end-stage heart failure (new york heart association class iii or iv). * patients who are currently participating or plan to participate in any interventional clinical trial * patients who are not prescribed gemigliptin or with counterindications for gemigliptin * patients who are considered not fit for the study by physician
effect of cryolipolysis on hormonal profile and menstrual regularityin obese with pcos

Conditions: Obese Women With PCOS

Summary: the effecting study to determine the impact of cryolipolysis on obese women with pcos

polycystic ovary syndrome(pcos) is the most common endocrine disorder in women of reproductive age. women with this syndrome may have infrequent menstrual periods or amenorrhea and excess androgen levels. the ovaries develop numerous small follicles and fail to ovulate on a regular basis, with subsequent subfertility in those women that wish to conceive.the etiology of pcos is unclear. early diagnosis and treatment may reduce the risk of long-term complications such as type 2 diabetes and heart disease ,pcos affects 5-20% of women of reproductive age worldwide. the condition is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology (pcom) with excessive androgen production by the ovaries being a key feature of pcos. pcos is classified into four separate phenotypes (a-d), according to the presence or absence of three characteristics: hyperandrogenism (either biochemical or clinical), ovulatory dysfunction and polycystic ovarian morphology. only phenotype a requires all three features of pcos to be present. the various diagnostic criteria currently available for pcos include a greater or fewer number of pcos phenotypes. ae-pcos, androgen excess-pcos society; nih, national institutes of health ,the trial made on 2group ,control group and study group for 3 months

Eligibility criteria:
inclusion criteria: all patient age from 18to 30 waist hip ratio \>.9 exclusion criteria: * thyroid disorders. hepatic diseases. skin or bleeding disorders. chronic disease or illnesscardiovascular and pulmonary disease,cancer diseases., renal failure disease. recent surgery. hose with pacemakers or surgical implants. musculoskeletal problems that would limit wbv.raynaud's phenomenon. a rare condition in which cold temperatures can impede blood flow to the fingers and toes. other conditions that pose a risk include,pregnancy or breast-feeding,inflammatory skin disorders,skin conditions caused by immune system disorders, such as eczema or psoriasis

Keywords: obesity, pcos ,cryolipolysis
arterial stiffness index as a predictor of surgically correctable primary aldosteronism

Conditions: Adenoma

Summary: our main objective is to assess whether aortic stiffness is a predictor of blood pressure response after surgery in patients with an aldosterone producing adenoma or a unilateral adrenal hyperplasia.

secondary objectives are to investigate whether aortic stiffness predicts cardiovascular , operative and postoperative morbid-mortality at 1 year, to evaluate the benefit of adrenalectomy in patients with primary aldosteronism due to unilateral adrenal hyperplasia and in patients with aldosterone producing adenoma associated with controlateral adrenal morphological abnormalities, and to participate to a national dna repository of patients with primary aldosteronism.

Eligibility criteria:
inclusion criteria: * patients with a surgically correctable primary aldosteronism due to an aldosterone producing adenoma or an unilateral adrenal hyperplasia * primary aldosteronism demonstrated by hormonal essays * hight resolution adrenal ct scan * operative decision based on the usual criteria of the different referent centers exclusion criteria: * patient's refusal to undergo the surgery or to participate in the study * the patients with pa due to bilateral adrenal hyperplasia or with idiopathic primary aldosteronism, and patients with a biochemical diagnosis of pa without evidence for a lateralized aldosterone excess.

Keywords: blood pressure antihypertensive treatments
percutaneous externally-assembled laparoscopic urologic surgery

Conditions: Urologic Diseases

Summary: this will be a single-arm prospective internally-controlled study. patients will undergo percutaneous externally-assembled laparoscopic surgery where one or more 3 mm instruments are added or substituted for conventional 5 or 10 mm trocars.

the investigators have previously published a study regarding the use of a new surgical paradigm (percutaneous externally assembled laparoscopy, or peal) in porcine and cadaveric models in order to allow laparoscopic surgery to take place with improved cosmesis and decreased pain while still allowing the use of larger instruments and maintaining instrument triangulation. the investigators now seek to study the use of these instruments in the human patients undergoing laparoscopic urologic surgery. this will be a single-arm prospective internally-controlled study. patients will undergo percutaneous externally-assembled laparoscopic urologic surgery where one or more 3 mm instruments are added or substituted for conventional 5 or 10 mm trocars. multiple outcome measures (endpoints) will be measured including time to first opioid use, total inpatient opioid dosage, patient ranking of painfulness of each port site, duration of ileus, time to ambulation, length of hospital stay, presence of any intraoperative or postoperative complications, operating time, estimated blood loss, and other routine parameters collected in a prospective surgical study.

Eligibility criteria:
inclusion criteria: * patients undergoing laparoscopic urologic surgery exclusion criteria: * patients unwilling to participate in the study * patients unfit for laparoscopic surgery

Keywords: minimally invasive surgical procedures
effect of self-administered exercises on prmd

Conditions: Pain

Summary: objective: to study the effects of self-administered exercises based on tuina techniques on the pain intensity caused by playing related musculoskeletal disorders (prmd) of professional orchestra musicians, using numeric visual scale (nvs). method: the investigators performed a prospective, controlled, single-blinded, randomized study with musicians suffering from prmd. n= 69 musicians were randomly distributed into the experimental and into the control group. after an individual diagnostic assessment, specific tuina self-administered exercises were developed and taught to the participants. musicians were instructed (educated) to repeat the exercises every day during 3 weeks. pain intensity was measured by nvs before the intervention and after the 1st, 3rd, 5th, 10th, 15th and 20th days of self-exercising. the procedure was the same for the control group, however the tuina exercises were executed in non-acupuncture points


Eligibility criteria:
inclusion criteria: * professional orchestra musician presenting playing related musculoskeletal pain during at least 3 weeks exclusion criteria:
effects of acute red raspberry consumption on vascular function in healthy individuals

Conditions: Healthy

Summary: accumulating evidence from epidemiological and human intervention studies indicates that the cardiovascular health benefits of diets rich in fruits and vegetables are (in part) related to their (poly)phenol content. raspberries are rich in phenolic and polyphenolic compounds, in particular procyanidins, ellagitannins and anthocyanins, but also phenolic acids. at present, a small number of randomized controlled trials investigating the effects of berry (poly)phenols on validated surrogate markers of cardiovascular disease risk have shown promising results. however, to date, very few human studies have specifically investigated the effects of raspberry (poly)phenols on cardiovascular function in healthy subjects. moreover, ellagitannin-derived metabolites are believed to persist for a long period of time in the blood and urine. therefore, the investigators will investigate the presence of plasma and urinary raspberry-derived metabolites 24h post-consumption. to the investigators knowledge, the effects of red raspberry consumption on vascular function in humans have not been investigated before. this information is necessary for the planning of long-term studies aiming to assess the potential beneficial effects of raspberries,. therefore, this study aims to investigate the potential role of red raspberry (poly)phenols in the modulation of vascular function by monitoring changes in vascular function together with the major (poly)phenol derivatives/metabolites in plasma.


Eligibility criteria:
inclusion criteria: * healthy male subjects (no clinical signs or symptoms of cardiovascular disease) exclusion criteria: * cardiovascular disease * acute inflammation * cardiac arrhythmia * renal failure * heart failure (nyha ii-iv) * diabetes mellitus * c - reactive protein \> 05 mg/dl * malignant disease * raspberry allergy/intolerance * hypotension (≤100 / 60 mm hg)

Keywords: polyphenols vascular function endothelial function raspberry
thulium fiber laser (tfl) vs holmium moses for treatment of benign prostatic hyperplasia (bph)

Conditions: Benign Prostatic Hyperplasia

Summary: benign prostatic hyperplasia (bph), the non-cancerous enlargement of the prostate, places pressure on the urethra and causes urination and bladder problems. transurethral resection of the prostate (turp) remains the gold standard treatment in most centres for bph. however, morbidity after turp is high, especially bleeding requiring blood transfusion and late postoperative bleeding. holmium laser enucleation of the prostate (holep) is a safe and effective procedure which has demonstrated comparable results to turp. holep also offers patients the alternative of being treated endoscopically with minimal blood loss, short catheterization time, and decreased hospital stay. the main reason holep has yet to become the new standard for treatment of symptomatic bph is due the complexity of this procedure as compared to turp. furthermore, the holep can be used with the mosestm system, a system that allows for more efficiency and ease of use of the holep. thulium fiber laser (tfl) enucleation of the prostate is an emerging technology for endoscopic prostate enucleation that is notable for its high wavelength and pulsed mode of action. recent studies have shown tfl enucleation of the prostate to be a safe and highly efficacious treatment modality for the management of large volume (\> 80 cm3) glands in bph. due to its novelty, further studies are needed to broaden the investigators' understanding of the tfl and comprehend the full implications and benefits of this new technology, as well its limitations. the aim of this study is to whether thulium fiber laser enucleation of the prostate (thuflep) and holmium laser enucleation using moses™ (m-holep) have comparable length of hospital stay, as well as intraoperative and postoperative outcomes.


Eligibility criteria:
inclusion criteria: 1. males over 50 years of age at the time of enrollment 2. referred to urology for refractory luts or urinary retention secondary to bph 3. failed medical (non-surgical) treatment 4. prostate size on preoperative trus of≥80 ml 5. ipss \>15 and qol score ≥3 and qmax \<15 ml/sec 6. written informed consent to participate in the study 7. ability to comply with the requirements of the study procedures exclusion criteria: 1. previous surgical treatment for bph 2. history of prostate cancer 3. prostate size \< 80 ml 4. history of urethral stenosis or its management 5. known or suspected neurogenic bladder 6. participants with active urinary tract infection until appropriately treated 7. participants with preexisting conditions, which, in the opinion of the investigator, interfere with the conduct of the study 8. participants who lack the capacity, or cannot speak english, in order to provide free and informed written consent