Kornimate/medical-research-clean huggingface dataset:
glivec® plus m-folfox avastin® in advanced colorectal cancer

Conditions: Advanced Colorectal Cancer

Summary: this is a phase i, dose finding, multicentre study evaluating the maximal tolerated dose of glivec® in combination with mfolfox-avastin®. patients will be enrolled into each dose level in 3 patient cohorts. additional cohorts will be enrolled, or dose levels opened, subject to the toxicities observed. once the mtd has been determined the dose level below will be re-opened and extra patients, to a total of 15, will be enrolled.


Eligibility criteria:
inclusion criteria: * histologically confirmed, locally advanced, recurrent or metastatic colorectal cancer * ecog 0 or 1 * measurable disease exclusion criteria: * prior first line therapy for advanced disease * significant bulk of metastatic disease or rapid progression * if prior adjuvant therapy, relapse within 6 months of a 5-fu based regimen or 12 months of an oxaliplatin based regimen other protocol-defined inclusion/exclusion criteria may apply

Keywords: colorectal, cancer
facial scanning for lip support assessment in full arch implant rehabilitations

Conditions: Lip; Prosthesis User; Soft Tissue

Summary: lip support plays an important role in facial esthetics, being a relevant factor when realizing full arch implant supported rehabilitations. however, there is a lack of research on the three dimensional impact of such restorations.

as lip support is becoming more determinant in the facial esthetics outcome after full arch implant rehabilitation, there is a need to know the influence of said rehabilitation in the lower third profile of the patients. then, through facial scanning, this study's purpose is to evaluate three dimensional changes that arise since the initial state that the patient presents to the office until is rehabilitated through 3d discrepancies and 2d linear measurements.

Eligibility criteria:
inclusion criteria: * indication for full arch implant rehabilitation exclusion criteria: * presence of facial hair, braces, make up, earrings or any facial deformity

Keywords: dental esthetics dental implants three-dimensional imaging oral surgery
turkish validity and reliability of the core lower urinary tract symptoms questionnaire in individuals with multiple sclerosis

Conditions: Lower Urinary Track Symptoms; Multiple Sclerosis

Summary: the aim of this study is to study the validity and reliability of core lower urinary tract symptoms score in patients with multiple sclerosis.

multiple sclerosis is an autoimmune disease that can affect any part of the central nervous system. multiple sclerosis, whose prevalence is increasing every year in the world, brings with it many symptoms. lower urinary tract symptoms develop secondary to demyelinating lesions in the spinal cord and pontine micturition center in the disease pathophysiology commonly seen in multiple sclerosis and other symptoms seen in multiple sclerosis (inactivity, fear of movement, etc.). due to the multifocal and widespread involvement of the cns, lower urinary tract symptoms in multiple sclerosis patients are variable and their severity varies among multiple sclerosis patients. lower urinary tract symptoms are divided into 3 groups as storage, voiding and post-voiding symptoms. the rate of urinary complications in multiple sclerosis patients is significantly higher compared to the general population. although it is a common symptom in multiple sclerosis , the evaluation of lower urinary tract symptoms in individuals with multiple sclerosis is quite limited in the literature. evaluation of lower urinary tract symptoms seen in multiple sclerosis with appropriate assessment tools is important to obtain comprehensive information about the progression of the disease. there are many questionnaires used in the evaluation of lower urinary tract symptoms. while the international prostate symptom score and the danish prostate symptom score, which are frequently used for benign prostatic hyperplasia, are used; overactive bladder questionnaire-v8 was developed to evaluate overactive bladder symptoms. however, these questionnaires are also frequently used in the evaluation of lower urinary tract symptoms. since the purpose of developing the questionnaires is for different diseases, they are not comprehensive enough for lower urinary tract symptoms. the core lower urinary tract symptoms score is a questionnaire developed to comprehensively evaluate lower urinary tract symptoms. although the core lower urinary tract symptoms score turkish validity and reliability study was conducted by erbay et al. in 2022, its validity and reliability in multiple sclerosis patients has not been performed.

Eligibility criteria:
inclusion criteria: * being between 18-65 years old * being diagnosed with multiple sclerosis by a specialist * being willing to participate in the study * being literate exclusion criteria: * not volunteering to participate in the study * having a neurological disorder that prevents speech

Keywords: lower urinary tract symptoms multiple sclerosis reliability validity
recovery time in children with lower respiratory tract infections treated with klacid® granules for oral suspension.

Conditions: Lower Respiratory Tract Infection

Summary: klacid granules for oral suspension provides short symptoms' recovery time in thai children with lower respiratory tract infections.


Eligibility criteria:
inclusion criteria: * patients with lower respiratory tract infection. * patient is male or female \> 6 months and \< 12 years of age. * prescription of klacid granules for oral suspension is at the discretion of the investigators according to the clinical condition of the patients * patients who are suitable for treatment with klacid granules for oral suspension according to the prescribing information exclusion criteria: * known hypersensitivity to or previously intolerant of macrolides. * illness severe enough to warrant hospitalization or parenteral therapy. * concomitant use of any of the following medications: * drugs metabolized by cyp3a isozyme: alprazolam, astemizole, carbamazepine, cilostazol, cisapride, cyclosporin, disopyramide, ergot alkaloids, lovastatin, methylprednisolone, midazolam, omeprazole, oral anticoagulants (e.g. warfarin), pimozide, quinidine, rifabutin, sildenafil, simvastatin, tacrolimus, terfenadine, triazolam and vinblastine. * drugs metabolized by other isozymes within cyp450 system: phenytoin, theophylline and valproate. * colchicine * digoxin * ritonavir. * severe immunodeficiency and chronic disease conditions. * renal or hepatic impairment.

Keywords: post-marketing observational study lower respiratory tract infections klacid granules for oral suspension
mapping the areas of the brain associated with language in children with epilepsy

Conditions: Epilepsy; Seizures

Summary: researchers are interested in studying if magnetic resonance imaging (mri) is practical for locating the areas of the brain associated with language in children with epilepsy. when a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). as the brain uses more fuel it produces more waste products, carbon dioxide and water. blood carries fuel to the brain and waste products away from the brain. as brain activity increases blood flow to and from the area of activity increases also. patients participating in the study will be asked to perform tasks designed to test language skills while undergoing an mri to detect areas of the brain using oxygen and receiving blood flow.

we propose to study the feasibility of utilizing mri to perform functional mapping of language cortex in children with epilepsy. we will use 1.5 tesla mri to study cerebral blood flow and tissue oxygenation during cognitive activation tasks derived from previous adult studies.

Eligibility criteria:
children aged 5-17 years. partial epilepsy (localized). ability to cooperate with task paradigms (iq greater than 65). no cardiac pacemakers, cochlear implants, shrapnel, vascular clips, braces, or claustrophobia. no one with inability to cooperate with task paradigms.

Keywords: neuroimaging seizures cerebral localization partial epilepsy epilepsy
retrospective study of outcomes with 3 mm implant for percutaneous bahs procedures

Conditions: Hearing Loss

Summary: this retrospective study is conducted to gain more knowledge on use and complications of 3mm long implants used in percutaneous (through the skin) bone-anchored hearing system (bahs) surgeries in adults. patients included have already been treated and recieved an implant with the wide diameter (ø: 4.5 mm) design, either of 3- or 4mm length. the main purpose of the study is to investigate implant survival three months after implantation.

bahs systems are intended for patients with conductive or mixed hearing loss, and for patients with single-sided deafness. in bahs surgery, an implant - coupled to a skin-penetrating abutment - is implanted in the bone behind the ear and is later loaded with a sound processor. the sound processor transforms sound waves to sound vibrations that are transferred through the skull bone to the inner ear(s)/cochlea. thus, sound can be transmitted directly to the cochlea and bypass any problems in the ear canal or middle ear. today, more than 400,000 implantations have been made around the world and the long-term success rate of bahs surgery is high, with a low rate of major complications. over the years, both implant design and surgical techniques have developed, with improved patient outcomes as a result. wider diameter implants, 4.5mm in diameter, increased the implant stability and have become standard. the implants exist in two different lengths, 3- and 4mm, to accomodate for different bone thickness. the shorter implant has primarily been used for (young) children and for adults with thinner bone. the aim of this restrospective study is to investigate the outcomes after implantation of a 3mm implant in an adult population.

Eligibility criteria:
inclusion criteria: * adult patient (≥19 years) receiving percutaneous bahs treatment using an implant with the wide diameter (ø: 4.5 mm) design. exclusion criteria: * patient undergoing re-implantation due to previous failure of osseointegration or other spontaneous implant loss. * patient undergoing conversions from passive transcutaneous devices (i.e. baha attract) to active percutaneous devices (using an abutment), using the same implant for attachment.
home based exercise program for elderly cancer patients

Conditions: Cancer Related Fatigue

Summary: implementation of a home based exercise program to reduce functional decline, cancer related fatigue (crf) and improve quality of life in the elderly gynecologic oncology patient problem: can prevention of crf and loss of function improve qol in the elderly gynecologic oncology patient undergoing chemotherapy? support: fatigue and its impact on qol is a major concern with the elderly patient receiving chemotherapy. when compared to younger adults qol is more important than gain in survival for elderly patients. (eyigor, et al., 2010). the national comprehensive cancer network recommends exercise as the most effective intervention for cancer related fatigue. methods: this is a single institution randomized controlled study to evaluate a home based exercise program in elderly gynecologic oncology patients undergoing chemotherapy. subjects will be randomized to the intervention group or to the control group receiving usual care. intervention group will receive a home exercise program 3 days weekly consisting of 30mins of strength and aerobic activity, utilizing a follow along exercise dvd and patient log to assist with compliance. the two groups will be compared by 1) objective pt assessment with the berg balance and 6 minute walk test (before or after) cycle 1 and 6, 2) subjective nursing assessment with the nhanes (national health and nutrition examination survey) and facit- f (functional assessment of chronic illness therapy: fatigue) prior to cycle 1 (baseline),4 (midpoint), and following cycle 6 (completion). conclusion: pt directed home exercise program may improve crf, functional decline, and qol in elderly gynecologic oncology patients undergoing chemotherapy.


Eligibility criteria:
inclusion criteria: * endometrial, ovarian, cervix, vaginal cancer initiating chemotherapy * age greater than or equal to 65yrs * ecog (eastern cooperative oncology group) performance status less than 3 * no current physical therapy intervention * english speaking exclusion criteria: * non-gynecologic malignancy * recurrent cancer * receiving radiation alone * gait or balance disturbance

Keywords: quality of life physical function
callsas study: effect of continuous positive airway pressure treatment for obstructive apnea on phone usage habits

Conditions: Sleep Apnea, Obstructive

Summary: continuous positive airway pressure (cpap) treatment improves sleepiness, depression and social activities in patients with obstructive sleep apnea (osa). this evolution can be captured from changes in phone usage habits coupled with a mobile-based services. the aim of this study is to assess the impact of cpap treatment on phone usage habits in osa patients.

callsas is a prospective study embarking newly diagnosed obstructive sleep apnea patients initiated to cpap treatment. the primary objective is to analyze the modifications in phone usage habits before and after cpap treatment. secondary objectives: * correlation between changes in phone usage habits and evolution of sleepiness * correlation between changes in phone usage habits and evolution of depression scale * correlation between changes in phone usage habits and evolution of quality of life * correlation between changes in physical activity measured by phones and evolution of physical activity objectively measured by actigraphy and gait platform * correlation between phone usage habits and cpap adherence

Eligibility criteria:
inclusion criteria: * newly diagnosed osa patients initiated on cpap * follow-up at home by agir à dom * customers of orange (or sosh) for mobile and/or fixed-line telephony for at least 6 months * patient who signed a written consent to participate in the study * patient affiliated to social security exclusion criteria: * pregnant women * patients with disease not allowing to realize functional and locomotion tests * person deprived of liberty by judicial or administrative decision, person subject to a legal protection measure (patient under guardianship or curatorship) * patient who, in the judgment of the investigator, may not be cooperative or respectful of the obligations inherent to participation in the study
protein supplementation in elderly with sarcopenic obesity undergoing caloric restriction and exercise

Conditions: Sarcopenic Obesity; Aging

Summary: this study aims to investigate if protein supplementation increases the benefits of exercise training in the elderly with sarcopenic obesity undergoing caloric restriction.

a major subset of adults over the age of 65 is now classified as having sarcopenic obesity, a high-risk geriatric syndrome predominantly observed in an aging population that is at risk of synergistic complications from both sarcopenia and obesity. lifestyle interventions such as caloric restriction and exercise training are effective nonpharmacological strategies to mitigate some adverse effects related to this condition. also, protein supplementation may boost the benefits of exercise, but this assumption is still to be tested. this trial aims to test whether protein supplementation is able to increase the benefits of exercise training in the elderly with sarcopenic obesity undergoing caloric restriction.

Eligibility criteria:
inclusion criteria: * 65 years and older; * body mass index (bmi) \> 30 kg/m2; * sarcopenia; * not engage into exercise training programas. exclusion criteria: * cancer in the last 5 years; * cognitive deficit or dementia that impossibility the patient to read and sign the informed consent form; * any disease that limits participation in exercise training program.
efficacy and complications of microvascular decompression

Conditions: Trigeminal Neuralgia

Summary: the study is a non-interventional prospective observational study in patients with trigeminal neuralgia that undergoes micovascular decompression. the aim is to evaluate the efficacy and complications 2 years after microvascular decompression

the aim of this study is to prospectively evaluate effect and complications 2 years after mvd using independent assessors of outcome and complications. data of outcome and complications is collected prospectively based on based on standardized follow-up schemes and questionnaires. patients were assessed by independent assessors before surgery and 3, 6, 12 and 24 months after surgery. current pain level was evaluated according to vas and bni pain scale. complications were evaluated by the assessors by a questionnaire and physical examination. all patients undergo a pre-surgical protocolized 3.0 tesla mri of the brain and brainstem.

Eligibility criteria:
inclusion criteria: * age 18 years or older. * most give signed informed consent. * must fullfil the ichd-3 beta diagnostic criteria for classical tn.patients with purely paroxysmal tn and patients with tn with concomitant persistent facial pain will be included. * if the ichd-3 beta diagnostic criteria is fulfilled and if complete clinical history, neurological and physical examination and a 3.0 tesla mri do not raise any suspicion of another causative disease such as painful posttraumatic trigeminal neuropathy or symptomatic tn, subjects with sensory abnormalities detected at clinical neurological examination are also included. * has had a 3.0 tesla mri according to the trigeminal neuralgia protocol, prior to the surgical intervention. * semi-structured interview and neurological examination by the independent assessors prior to neurosurgical intervention. * has tried at least one, preferably two, sodium channel blocker (either carbamazepine or oxcarbazepine) before referral to neurosurgery. exclusion criteria: subjects will be excluded if one of the following exclusion criteria is met: * psychiatric or mental illness or condition that might interfere with the ability of the patients to fill in the informed consent and questionnaires. * previous microvascular decompression as a treatment for trigeminal neuralgia

Keywords: neurosurgery
a research study to evaluate the safety and effectiveness of mk0217 to prevent and treat bone loss (0217-193)(completed)

Conditions: Osteoporosis

Summary: a research study to see how safe and effective mk0217 is when taken weekly for the prevention and treatment of steroid induced bone loss.


Eligibility criteria:
inclusion criteria: * man or woman aged 18 to 80 years, being treated with oral glucocorticoid (steroid), without vertebral fracture or prior osteoporotic fracture exclusion criteria: * mentally or legally incompetent, pregnant, alcohol or drug dependence, history of heart disease, kidney disease, hypertension, upper gastrointestinal disease, cancer, being treated with hormone replacement therapy, or life expectancy of less than 3 years

Keywords: glucocorticoid
clinical trial to compare the pharmacokinetics and safety of eperisone hcl sr tablet 75mg and myonal tablet 50mg

Conditions: Low Back Pain

Summary: the purpose of this study is to evaluate and compare safety and pharmacokinetic of the eperisone hcl sr and myonal in healthy korean male adults.

myonal: eperisone hydrochloride (muscle relaxant)

Eligibility criteria:
inclusion criteria: * healthy male subjects age between 20 and 55 singed informed consent exclusion criteria: * hypotension or hypertension has a history of allergy reaction of this drug or other drugs
algovita spinal cord stimulation system hi-fi study

Conditions: Chronic Pain

Summary: the objective of this study is to obtain post-market clinical outcome data for the algovita scs system when used on-label, according to the applicable directions for use, using high fidelity tonic stimulation at either ultra-high pulse width or traditional pulse width for the treatment of persistent or recurrent back and/or leg pain following spinal surgery.


Eligibility criteria:
inclusion criteria: * patients with fbss defined as persistent or recurrent back and/or leg pain despite one or more anatomically successful back surgeries for the same original pain. * age 18-75 years old at consent. * targeted pain intensity of ≥ 5 out of 10 on the baseline visit nrs. * odi score of 41-80 out of 100 at the baseline visit. * appropriate candidate for the surgical procedure and algovita scs therapy based on the clinical judgment of the investigator and the algovita instructions for provider (ifp) in the nuvectra product manuals. * on stable pain medications for at least 28 days prior to consent. stable is defined as no new or discontinued pain medications and no changes to total daily dose of any pain medications. * willing and capable of providing informed consent. * willing and able of complying with the study-related requirements, procedures, and visits. * speaks english as a primary language (as the algovita patient manuals are only currently available in english). * has adequate cognitive ability to use the subject devices (e.g., ppc, pop), as determined by the investigator. exclusion criteria: * has a medical/psychological/psychiatric condition/disorder that could interfere with study procedures as determined by the investigator. * has a coexisting pain condition that might confound pain ratings, as determined by the investigator. * has a condition currently requiring or likely to require the use of mri or diathermy. * has an existing drug pump, scs system, or other active implantable device. * has any prior scs experience. * pregnant or planning to become (if female and sexually active, subject must be using a reliable form of birth control, be surgically sterile, or be at least 2 years postmenopausal). * for subjects with diabetes, hba1c ≥ 8.5% as measured at the baseline visit (or within the 3 months prior to the baseline visit). * participating in another clinical trial that could affect the outcomes or requirements of this study as determined by the investigator. * involved in an injury claim under current litigation or have a pending or approved workers compensation claim.
just-in-time adaptive interventions (jitais) in a digital mental health intervention for middle-aged and older adults with chronic pain

Conditions: Chronic Pain; Depression, Anxiety

Summary: the purpose of this research study is to refine customized in-app notifications in order to optimize users' experience with a mobile app called wysa for chronic pain. this app is designed to support people who have chronic pain and who also experience symptoms of depression and/or anxiety. this version of the app is not currently available to the public. eligible participants will be asked to download and use the wysa for chronic pain study app for several weeks, and to use it as they normally would if they were not part of a research study. at the beginning and end of the study period, participants will be asked to complete brief surveys about their mood, pain, physical function, and sleep. additionally, a few participants will be asked to share their experience with the study app at the end of the research study in a casual interview using a secure audio/video recorded call. participating in the interview portion is optional.


Eligibility criteria:
inclusion criteria: * 45 years or older * at least moderately severe depression and/or anxiety symptoms (patient health questionnaire-9 (phq-9) and/or generalized anxiety disorder-7 (gad-7) score ≥ 10) * chronic pain (i.e., pain on most days or every day in the past three months) exclusion criteria: * frequent active suicidal ideation * no access to a mobile device * not living in the united states

Keywords: jitai digital mental health intervention older adults middle-aged adults app smartphone chronic pain depression anxiety chatbot