Kornimate/medical-research-clean huggingface dataset:
intensified insulin therapy with telemedicine

Conditions: Intensified Insulin Therapy; Diabetes

Summary: investigation of the effect of a 3-month telemedicine-led lifestyle intervention in individuals requiring intensified insulin therapy.

the primary objective of this study was to evaluate the development of hba1c levels in patients requiring 3 months of intensified insulin therapy using standard therapy and telemedicine devices currently in use. the telemedicine system contains a mobile phone-based nutrition diary, bluetooth-related wrist activity meter, weight scale, blood pressure monitor, blood glucose meter, and it system for transmitting and displaying data from these devices.

Eligibility criteria:
inclusion criteria: * women or men between the ages of 18 and 75 * patient with diabetes who needs intensified insulin therapy hba1c\> = 8% * it proficiency is at least basic for cell phones (answering / making a voice call). * signing a informed consent * for women with childbearing potential, by definition, all women who who are physiologically able to conceive are twofold use of contraception * the subject communicates well with the investigator and is able to perform the test to understand and help comply with the requirements of the protocol exclusion criteria: * informed refusal any time after the sign of the informed consent * planned invasive cardiac intervention (catheter vasodilation or surgical coronary artery bypass grafting, keyboard surgery or replacement) * tumor disease * pregnant or lactating women * any medical condition that does not allow participation

Keywords: telemedicine
comparing effects of diet, with or without exercise, on sexual, urinary and endothelial function, inflammatory profile and quality of life in obese men

Conditions: Sexual Dysfunction; Endothelial Dysfunction; Quality of Life; Inflammation

Summary: this study aims to compare the effects of 8 months of diet modification, with or without exercise, on weight loss, sexual, urinary and endothelial function, systemic inflammation and quality of life in obese men.


Eligibility criteria:
inclusion criteria: * male, aged 30-65 years * body mass index (bmi) \>/= 27.5 kg/m2 * waist circumference (wc) \>/= 90 cm exclusion criteria: * pituitary disease or cranial radiotherapy * previous or current androgen replacement or deprivation therapy * current treatment for sexual problems or luts * glomerular filtration rate \< 60 ml/min * liver disease * alcohol intake exceeding 500 g/week in the previous 12 months * use of opiates, glucocorticoids, recreational drugs or phosphodiesterase inhibitors

Keywords: obesity men sexual function urinary tract symptoms endothelial function inflammation quality of life
hydroxyethyl starch and renal function after hip replacement surgery

Conditions: Osteoarthritis

Summary: the purpose of this project is to investigate if hydroxyethyl starch (hes) is potential nephrotoxic and examine the effects on the circulation and kidneys during administration of hes during surgery.

hydroxyethyl starch (hes) is widely used in hospitals to maintain circulation in critically ill patients. in recent years studies have raised suspicion that hes is nephrotoxic. so far acute kidney injury has been diagnosed based on creatinine measurements, but new technology allows for earlier diagnosis using measurements of biomarkers in urine. the purpose of this project is to investigate hes's potential toxicity and effects on the circulation and kidneys using measurements of biomarkers specific for toxicity and for the sodium/water balance in the urine and by measurements of vasoactive hormones in the blood after administration of hes 130/0.4

Eligibility criteria:
inclusion criteria: * age \> 18 years * males and females * indication for arthroplasty of hip exclusion criteria: * blood donation within the last month * lack of wish to participate * egfr\< 15ml/min * pregnancy or breast feeding * need of nsaid
the effect of bevacizumab (avastin) on pterygium

Conditions: Pterygium

Summary: the purpose of this study is to determine whether local injection of bevacizumab might halt and or cause regression of pterygium growth. this may enable earlier treatment and prevention of pterygium growth into the patient's line of sight thereby limiting the need for surgery and improving quality of life for patients with pterygia.


Eligibility criteria:
inclusion criteria: * 19 years of age and older * diagnosis of pterygia * healthy enough to make scheduled follow-up visits exclusion criteria: * women of childbearing potential and males who plan to father a child during their participation in the study will be excluded from the study.
weekly phone calls versus brief patient education to improve continuous positive airway pressure (cpap) compliance

Conditions: Obstructive Sleep Apnea (OSA)

Summary: the purpose of this study is to compare the effects of three interventions on cpap adherence.

to determine whether there is a need for a more intensive one on one interaction with the patient in order to improve cpap usage. and also to try to identify in general which population of patients may require a more intensive intervention.

Eligibility criteria:
inclusion criteria: * all new patients undergoing of the sleep center suspected of having sleep apnea and undergoing sleep studies exclusion criteria: * refusal to participate, or not suspected of having sleep apnea prior to the study

Keywords: osa cpap
fecal bacterial flora in clostridium difficile-associated diarrhea

Conditions: Enterocolitis; Pseudomembranous Colitis; Antibiotic-Associated Colitis

Summary: the investigators propose to study intensively the bacteriology of feces in c. difficile associated diarrheal disease, using a variety of conventional and very up-to-date techniques.

clostridium difficile associated colitis is an increasing problem in hospitals throughout the developed world; the number of cases has increased, and the failure to respond to conventional therapy has become far more common. the investigators have recently documented in the medical literature (clin infect dis, june, 2005; lancet infect dis, august, 2005). possible reasons for failure of treatment include persistence of c. difficile and/or imbalance of other bacterial flora in the colon. the bacteriology of fecal flora in c. difficile associated diarrhea has not been studied.

Eligibility criteria:
inclusion criteria: * patients with antibiotic-associated diarrhea with a positive assay for c. difficile toxin * patients with antibiotic-associated diarrhea with 3 negative assays for c. difficile toxin * patients with antibiotic-associated diarrhea that has failed to respond to conventional therapy * hospitalized patients who have received \>2 antibiotics and who have no symptoms of diarrhea or abdominal discomfort exclusion criteria: * none

Keywords: clostridium difficile associated diarrhea
washed microbiota transplantation in solid organ transplantation

Conditions: Solid Organ Transplant Complications

Summary: solid organ transplantation (sot), an alternative therapy for end-stage diseases, offers increased longevity and better quantity of life. posttransplant complications such as gastrointestinal symptoms, infection, and graft rejection increase risk with graft failure and death. however, the treatment of abovementioned complications remains unsatisfactory. gut dysbiosis has been reported in patients with sot, especially in patients with posttransplant complications. recipients are more susceptible to gut dysbiosis as long-term use of immunosuppressants, antibiotics and corticosteroids. restoring gut microbiome may be a promising therapy for posttransplant complications. washed microbiota transplantation (wmt) is a newly improved methodology of fecal microbiota transplantation based on automatic facilities, washing process and a new delivery routine. in this study, investigators aimed to evaluate the efficacy and safety of wmt for postoperative complications in sot.


Eligibility criteria:
inclusion criteria: 1. solid organ transplantation recipients; 2. suffering from gastrointestinal symptoms (e.g. diarrhea, constipation, abdominal pian), infection (e.g. clostridium difficile, urinary infection) post-transplantation, graft rejection and so on; 3. is willing to undergo wmt and provide written informed consent; exclusion criteria: 1. patients with history of gastrointestinal diseases or homologous pathogen infection pre-transplant; 2. pregnant or lactating females; 3. unable to understand the purpose of the study, communicate effectively with investigators and comply with all study procedures; 4. follow up less than 1-month post-wmt; 5. other conditions judged by investigators not suitable for study participation;

Keywords: solid organ transplant complications washed microbiota transplantation fecal microbiota transplantation diarrhea clostridium difficile
covid-19 infection

Conditions: COVID-19; Renal Transplant Infection

Summary: post-transplant patients with covid-19 infection who attended shenzhen no. 3 hospital from december 2022 to february 2023, and enrolled the general population with covid-19 infection who were hospitalized during the same period, matched by age and gender.

data collection：age, bmi, underlying comorbidities and other basic information were collected retrospectively from the two groups. the medical records were used to collect information about the patients' new coronavirus infection, such as the time of onset of symptoms, time of diagnosis, time of conversion and common symptoms such as fever, cough, nasal congestion and runny nose, muscle aches and pains.to compare the differences of the diagnosis and treatment of ktrs and the general population infected with omicron

Eligibility criteria:
inclusion criteria: confirmed novel coronavirus infection between december 2022 to february 2023, exclusion criteria: age less than 18; failure of the transplanted kidney before the new coronavirus infection; exclusion of oral immunosuppressed and other types of organ transplant recipients from the non-renal transplant population
effect of capros supplementation on cardiovascular disease risk factors in humans

Conditions: Hyperlipidemia

Summary: the hypothesis of this study is that the natural supplement capros will decrease ldl levels, platelet aggregation, and serum concentrations of high sensitivity c-reactive protein in humans at risk for cardiovascular disease.

a non-randomized, longitudinal study to determine the effect of capros supplementation on a lipid profile, platelet aggregation and high-sensitivity c - reactive protein in 30 volunteers at risk for cardiovascular disease. -herbal polyphenols/antioxidants: role in cardiovascular disease prevention: phenolic compounds are dietary antioxidants found in plants that are shown to inhibit ldl oxidation, inhibit platelet aggregation and adhesion, decrease total and ldl cholesterol, and induce endothelium-dependent vaso-relaxation. \[lapointe, vita, and mendes\]. epidemiologic studies suggest that higher polyphenol intake from fruits and vegetables is associated with decreased risk for cardiovascular disease. among the numerous plausible mechanisms by which polyphenols may offer cardiovascular protection, improvement of the endothelial function and inhibition of angiogenesis and cell migration and proliferation in blood vessels have been the focuses of recent studies. antioxidants in polyphenols, in addition to protecting ldl cholesterol against oxidation, may act at a vascular cell level by limiting cellular production of reactive oxygen species, and, thus, cell-mediated ldl oxidation. in traditional indian medicine, the gooseberry (phyllanthus emblica) has been used for thousands of years as an effective source of polyphenols and antioxidants. "p. emblica is considered beneficial against various diseases namely cancer, diabetes, liver treatment, and various other diseases."\[hiraganahalli\]. capros®, from natreon, inc., is a cascading antioxidant ingredient derived from phyllanthus emblica. it has been used in cosmetics and food-and-beverage formulations in many countries, and, based on extensive scientific research, also shows particular promise as a dietary supplement.

Eligibility criteria:
inclusion criteria: * patients 21-70 years of age * bmi 25-35 exclusion criteria: * bmi \> 35 or \< 25 * smokers * individuals who are deemed unable to understand the procedures, risks and benefits of the study, i.e. informed consent will be excluded * females who are pregnant as well as individuals who are therapeutically immuno-compromised will also be excluded in order to minimize the risk to such individuals (and fetus) and to decrease statistical variability and to minimize potential of confounders. * candidates for inclusion into the study will not include individuals as defined in 45 cfr 46 subparts b, c and d, nor from any other population which may be considered vulnerable. pregnant women are excluded to minimize the risk to such individuals (and fetus) and to decrease statistical variability and to minimize potential of confounders.

Keywords: ldl cholesterol anti-hyperlipidemic hyperlipidemic capros natural supplement
graded activity versus supervised exercises in patients with chronic non-specific low back pain

Conditions: Low Back Pain

Summary: the purpose of this study is to compare the efficacy of graded activity program and supervised exercise on pain, functional disability, quality of life, global perceived effect, return to work, physical activity, physical capacity and strength of the lower limbs in patients with chronic non-specific low back pain

objective: to contrast the efficacy of of graded activity program and supervised exercise on pain, functional disability, quality of life, global perceived effect, return to work, physical activity, physical capacity and strength of the lower limbs in patients with chronic non-specific low back pain design: sixty-six will be randomized into two groups namely: graded activity program (ga)(n = 33) and supervised exercise (se) (n = 33). the primary clinical outcomes will be pain, assessed with the numerical pain scale and mcgill pain questionnaire, and disability assessed with roland morris disability questionnaire. secondary outcomes will be measured with global perceived effect, quality of life, return to work, physical activity, functional capacity and strength of the lower limbs. the program lasts for 6 weeks, and sessions happen twice a week, with duration of one hour each. evaluations will be performed before(baseline), after (6weeks) and with a follow-up 3 and 6 months after treatment. data will be collected by a blinded examiner who also had made the allocation of patients to groups. significance level is established at 5%.

Eligibility criteria:
inclusion criteria: * patients with non-specific chronic low back pain for at least three months, age between 18 and 65 year of both genders and with a minimum pain intensity score of three in the 11-point pain numerical rating scale (ranging from 0 to 10 points). exclusion criteria: * known or suspected serious spinal pathology (fractures, tumors, inflammatory or infective diseases of the spine); * nerve root compromise; * comorbid health conditions that would prevent active participation in the exercise programs; * pregnancy; * cardio respiratory illnesses;
compression and functional ability after endovenous varicose vein treatment

Conditions: Varicose Veins of Lower Limb; Varicose Veins

Summary: study's aim is to study possible differences in post-operative rehabilitation, functional ability and visual disturbances after endovascular varicose intervention (rf-catheter and foam sclerotherapy) in two study groups, where patients will be randomised to either no compression group (group i) or compression group (group ii)


Eligibility criteria:
inclusion criteria: * duplex ultrasound verified gsv, aasv and/or ssv incompetence suitable for radiofrequency ablation * comprehensive classification system for chronic venous disorders (ceap) rated from c2 to c4 * distal varicose vein insufficiency suitable for sclerotherapy * patient willingness to participate exclusion criteria: * history of pulmonary embolism or deep venous thrombosis * large (\>12mm) truncal vein diameter * ceap c5-c6 * antithrombotic medication (asa accepted)

Keywords: varicose veins compression stockings sclerotherapy radiofrequency ablation
a pilot study of the safety of mc-1101 in both normal volunteers and patients with early dry amd

Conditions: Age-Related Macular Degeneration

Summary: the safety and comfort of repeated administrations of a topically-administered ophthalmic formulation of mc-1101 will be established through investigator assessments and subject reporting over a 3 day period. safety assessments will be performed on both normal, healthy subjects as well as those with the signs and symptoms of early non-exudative age-related macular degeneration (dry amd).


Eligibility criteria:
inclusion criteria: * clinical diagnosis of dry amd or; * normal, healthy volunteer exclusion criteria: * uncontrolled systemic disease * women who are pregnant, nursing, or planning a pregnancy during the study's duration
regulatory network and diagnostic value of key autophagy-related genes in sepsis

Conditions: Sepsis; Autophagy

Summary: autophagy plays an important role in the occurrence and development of sepsis. this study aims to explore and verify the key autophagy-related genes in sepsis, then construct their regulatory networks and evaluate their potential diagnostic value, so as to provide new ideas for the diagnosis and treatment of sepsis.

(1) sepsis-related datasets gse65682,gse134347 and gse134358 were downloaded from geo database, and demrna,delncrna and demirna were obtained by differential analysis. (2) autophagy related genes (args) were obtained from human autophagy database, and args in gse65682 and gse134347 were extracted. deargs were obtained by differential analysis, and go and kegg enrichment analysis were performed. (3) sepsis-related genes were obtained by wgcna analysis, and key deargs in sepsis were obtained by intersection with deargs, and then transcription factors and cerna regulatory network were analyzed. (4) immune infiltration analysis was used to evaluate the distribution of immune cells in the blood of patients with sepsis, and its correlation with key deargs was further analyzed. (5) the diagnostic functions of key deargs were analyzed. (6) peripheral blood samples from sepsis patients and healthy controls were collected and verified by rt-qpcr.

Eligibility criteria:
inclusion criteria:1) over 18 years old; 2) meeting the diagnostic criteria of sepsis 3.0; 3) hospital stay longer than 24 hours. exclusion criteria:1) malignant tumor; 2) autoimmune diseases; 3) use of immunosuppressants in the past two weeks; 4) readmission or transfer from another icu due to the same disease.

Keywords: sepsis autophagy
effects of a comprehensive patient-centered health service in cystic fibrosis (vemse-cf)

Conditions: Cystic Fibrosis

Summary: for the project vemse-cf, a comprehensive patient-centered outpatient health service model was developed offering focused interventions in different areas. these included patient education, as well as nutritional and exercise counselling. special emphasis was given to the psycho-social services. the implementation was supported by a case manager. the model was implemented in three german cf-centers. for evaluation, patient data from 13 additional german cf-centers offering standard care was used as comparison. in total, 153 patients in the intervention group and 163 control patients aged 5-52 years contributed data. the primary endpoint was the number of bmi- and fev1-measurements over 24 months. secondary endpoints included mortality, lung transplantation, fev1, bmi, adherence to therapy, quality of life, and mental stress.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of cystic fibrosis - written informed consent * intervention group: care in one of the 3 cf-centers * control group: care in one of the 13 control cf-centers exclusion criteria: * post lung transplantation * listed for lung transplantation and planned inpatient stay for more than 4 weeks

Keywords: health services fev1 bmi quality of life mental stress
assessing dose taken in opioid use disordered patients with an electrochemical sensor

Conditions: Adherence, Medication; Opioid Use Disorder

Summary: cari health aims to develop a methadone dose taken sensor that provides real-time data on interstitial fluid (isf) levels that could be used as a methadone adherence monitor for daily doses. use of such a monitor would allow for the physician, counselor, patient, and family member to remotely verify that a physician prescribed dose has been taken. such a verification system can allow methadone clinics greater flexibility in the provision of take-home doses and thus retain more patients in the clinic.

three specific phases and 9 aims are proposed for first-in-human studies of a remote medication monitor for dose taken in patients taking methadone for opiate use disorder. phase 1 detection over 3-6 hours (n=10) aim 1: detect methadone and one or more of its metabolites in interstitial fluid (isf) with differential pulse voltammetry (dpv) aim 2: correlate in vitro blood-based lc-ms and dpv scans with intradermal microneedle based dpv scans aim 3: accurately identify that a dose of methadone has been taken aim 4: determine the frequency and severity of any adverse events up to 6 hours. phase 2 detection over 12 hours (n=15) aim 5. quantitate methadone and one or more of its metabolites in isf with dpv over 12 hrs. aim 6: determine the frequency and severity of any adverse events up to 12 hours phase 3 detection over 3 days n=20 ( 15 single dosed subjects, 5 split dosed subjects ) aim 7. quantitate methadone and one or more of its metabolites in isf with dpv over 3 days. aim 8. accurately identify a dose or half a dose has been taken aim 9: determine the frequency and severity of any adverse events up to 3 days

Eligibility criteria:
inclusion criteria for methadone group includes: age 18-70. a prescription for liquid methadone at a dose of 10mg or more. taken methadone as prescribed in the last 2 days. has been prescribed at least 3 take homes exclusion criteria for methadone group includes: age \ 70. a condition preventing or complicating isf collection. conditions may include dermatological (skin) condition, immunodeficiency, bleeding diathesis, recent blood donation, anemia, cancer, congestive heart failure, or tuberculosis. any active severe depression (e.g., suicidal ideation) or mania symptoms. pregnancy, or intending to become pregnant during the course of the study. patients determined to be unstable for enrollment or take homes by the outpatient treatment program (otp). under a conservatorship.

Keywords: pharmacokinetics differential pulse voltammetry remote medication monitor interstitial fluid