Kornimate/medical-research-clean huggingface dataset:
promoting recovery after stroke with amantadine

Conditions: Stroke, Ischemic; Stroke Hemorrhagic

Summary: the investigators aim to examine whether amantadine can help patients recover from stroke. this will be a blinded randomized clinical trial (rct). patients will be randomized post-ischemic or hemorrhagic stroke either to the placebo arm or amantadine arm. patients will be on study drug or placebo for 1 month but will be enrolled for 3 months total. at various time points patients will be examined and fill out questionnaires to determine level of stroke recovery.


Eligibility criteria:
inclusion criteria: 1. 18 to 85 years old, male and female 2. modified rankin score (mrs)\<=2 prior to stroke 3. ischemic or hemorrhagic stroke as diagnosed by vascular neurologist or as proven on magnetic resonance imaging (mri) or non-contrast head computed tomography nchct) 4. 24 hours to 3 weeks after stroke onset or time last known well prior to detection of symptoms 5. national institute of health stroke scale (nihss)\>=3 and nihss\<=15 6. creatinine clearance of greater than or equal to 60 ml/min using the cockroft- gault equation. 7. have passed a swallow evaluation prior to drug administration 8. the patient is an acute rehabilitation candidate or candidate for the homeward stroke program 9. able to participate in administered tests exclusion criteria: 1. any degree of receptive aphasia 2. moderate or severe expressive aphasia 3. currently pregnant or plans to get pregnant 4. currently breastfeeding 5. any patient admitted with primary subarachnoidh emorrhage (sah )on either non-contrast head ct or mri brain 6. diagnosis of dementia or mild cognitive impairment prior to index stroke 7. prior limb amputation 8. currently prescribed or taking a primary anticholinergic medication 9. currently enrolled in any other investigational pharmacologic or procedural clinical trial 10. malignancy with active treatment 11. history of prior stroke with residual impairment 12. current or prior neuroleptic use 13. history of suicidality or psychosis (the columbia suicide severity ratings scale (c-ssrs) will be administered at the screening visit to assess depression and suicidal thoughts for subject eligibility. any subjects who indicate severe depression or suicidal thoughts and/or attempts within the last year will not be eligible) 14. prior history of seizures 15. prior treatment with amantadine 16. parkinson's disease 17. amantadine allergy 18. elevated liver function tests (aspartate aminotransferase and alanine aminotransferase above the upper limit of normal) -
covid-19 post-vaccination observation

Conditions: Immune System Diseases; COVID-19 Vaccine Adverse Reaction; Immune System Disorder

Summary: the study started after the second covid-19 vaccination of the participant with blood spots appearing on the skin with severe arthritis. the study continued to the third-dose full vaccination of the participant with the recombined covid-19 vaccination and afterwards. the study completed until intervention.


Eligibility criteria:
all covid-19 vaccinated are eligible for inclusion.
gao bipolar spectrum lithium/quetiapine study

Conditions: Bipolar Disorder

Summary: this is a 4-month randomized open-label comparative safety, tolerability, and effectiveness trial of lithium versus quetiapine for subjects presenting in any phase of bipolar who currently require a medication change for their illness. stratified randomization will reduce bipolar type i , bipolar type ii , or sub-threshold imbalance across cells. the enrollment goal is 60 subjects, over 24 months from initial regulatory approval. the primary outcome is the difference between lithium and quetiapine in the time to 'all cause' medication discontinuation.


Eligibility criteria:
inclusion criteria: * able to provide informed consent before beginning any study-specific procedures * male and female patients at least 18 years of age * meets diagnostic and statistical manual -iv criteria for bpi, bp ii, or national comorbidity survey-r criteria for sub-threshold bp with or without symptoms, in need of medication adjustment(s) * willing to be randomized to either lithium or quetiapine * if a sexually active female of childbearing potential, be using a reliable method of contraception, such as oral contraceptive or long-term injectable or implantable hormonal contraceptive, double-barrier methods (e.g. condom and diaphragm, condom and foam, condom and sponge), intrauterine devices, and tubal ligation * women with reproductive potential must have a negative urine pregnancy test exclusion criteria: * unwilling to comply with study requirements * patients who have had severe adverse reaction to lithium or quetiapine * patients who require inpatient care * drug/alcohol dependence requiring immediate acute detoxification * pregnancy as determined by serum pregnancy test or breastfeeding * history of nonresponse to lithium at doses \>900 mg ≥8 wks or to quetiapine at doses of at least 300 mg/d ≥ 8 week for depression and at least 400-600 mg/d ≥ 4 wks for mania.
comparison of efficacy and safety of repaglinide combined with insulin nph versus biphasic human insulin 30 alone in inadequately controlled subjects with type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in europe. the aim of this trial is to compare the efficacy and safety of repaglinide combined with insulin nph versus biphasic human insulin 30 alone in type 2 diabetics inadequately controlled with sulfonylurea (su) +/ biguanide therapy


Eligibility criteria:
inclusion criteria: * hba1c: 7.5-11.0% on current therapy * oha (oral hypoglycaemic agent) treatment for a minimum of two years * bmi (body mass index): 25-32 kg/m2
effect of muscle coactivation strengthening for rotator cuff tendinopathy

Conditions: Tendinopathy

Summary: rotator cuff tendinopathy (rct) is the most frequent cause of shoulder pain. rct is frequently termed as impingement syndrome, based on the underlying mechanism in which the subacromial space soft tissues (subacromial bursa, rotator cuff tendons and long head of the biceps tendon) get encroached under the coracoacromial arch when the arm is elevated. rct contributes in the decrease in quality of life and function, and in inducing work incapacities and sleep disorders. exercises, as conservative management, were shown to be effective in increasing function and in decreasing pain related to rct. however, the lack of studies comparing different types of exercises (i.e. concentric, eccentric, scapular strengthening, proprioceptive, coactivation) is reported by many systematic reviews. one type of exercise, coactivation strengthening, could be more efficient. coactivation strengthening implies a recruitment of the pectoralis major and the latissimus dorsi while performing regular strengthening. when theses muscles are recruited, the medio-inferior orientation of their tendons creates a force vector that limits the superior translation of the humeral head, thus limits the subacromial narrowing. the aim of this study is to evaluate the efficacy of coactivation strengthening exercises in patient with rct compared to regular strengthening exercises. forty-two participants diagnosed with rct by an orthopaedic surgeon following a standardized protocol will be randomised to either coactivation or regular strengthening exercises. participants will perform a 6-week exercise protocols. outcomes will be measured at baseline, and at three, six, 12, 18 and 24 weeks. the primary outcome is function assessed with the disabilities of arm, shoulder and hand (dash) questionnaire. secondary outcomes focus on pain (visual analog scale), quality of life (western ontario rotator cuff index), impression of change (patient global impression of change), subacromial distance (ultrasonography) and muscular strength (manual dynamometer). investigators expect that coactivation strengthening exercises will be more efficient over the short and long term. this trial will provide data to guide clinicians in the treatment of rct to reduce recovery time and to bring patients back as quickly as possible to work or usual function.


Eligibility criteria:
inclusion criteria: * 18-65 years old * experienced shoulder pain \> four weeks * positive painful arc test * positive neer or hawkins kennedy test * pain at resisted isometric movement of abduction or external rotation exclusion criteria: * any other shoulder pathology * rotator cuff complete tear * history of shoulder surgery * any systemic inflammation or neurological condition * received a corticosteroid injection \< six weeks * any known cognitive condition

Keywords: rotator cuff tendinopathy exercises coactivation strengthening
self-administered tdcs for improving single- and dual-task gait in patients with pd

Conditions: Parkinson Disease

Summary: the purpose of this study is to investigate the efficacy and safety of self-administered transcranial direct current stimulation to improve the single- and dual-task gait in patients with parkinson's disease.

parkinson's disease (pd) is a disease caused by dopamine deficiency in the striatum resulting from the loss of dopaminergic neuronal cells in the cerebral substantia. it is a progressive neurodegenerative disease characterized by motor symptoms including gait disturbance and balance instability. in the early stages of parkinson's disease, dysfunction of the sensorimotor area of the basal ganglia typically occurs, leading to habitual control hurdles. accordingly, cognitive efforts are required to perform habitual tasks such as walking, and the automaticity of walking is reduced. dual-task performance involves a complex interplay of motor functions as well as cognitive functions such as attention and executive function. one way to potentially reduce the cost of dual-tasking and the negative effects of motor-cognitive interference is to consider improving the corresponding component, i.e., motor or cognitive function. transcranial direct current stimulation (tdcs) is a non-invasive brain stimulation method that can be used to change cortical activity. recently, there has been growing attention on tdcs as an adjunct tool for rehabilitation. several tdcs studies in patients with pd have reported the positive results of tdcs on motor and cognitive function. most studies have examined changes before and after a single session of stimulation, with limited research verifying the cumulative and long-term effects of tdcs. therefore, this study aims to investigate the efficacy and safety of self-administered transcranial direct current stimulation to improve the single- and dual-task gait in patients with pd.

Eligibility criteria:
inclusion criteria: * clinically diagnosed as idiopathic parkinson's disease by neurologists according to the uk parkinson's disease society brain bank criteria * modified hoehn \& yahr stage 2, 2.5, or 3 exclusion criteria: * history of seizure * metallic implants, such as cardiac pacemaker or an artificial cochlea * patients with inflammation, burns, or wounds in the stimulation area * parkinson's disease dementia; cut-off is \< 7 of korean-montreal cognitive assessment for illiterate patients, \< 13 for those educated for 0.5-3 years, \< 16 for 4-6 years of education, \< 19 for 7-9 years of education, and \< 20 for 10 or more years of education. * severe dyskinesia or severe on-off phenomenon * plan to adjust medication at the time of screening * other neurological, orthopedic, or cardiovascular co-morbidities significantly affecting gait function * uncontrolled vestibular disease, orthopedic hypotension, or paroxysmal vertigo * pregnant or lactating patients * other comorbidities that make it difficult to participate in this study

Keywords: parkinson disease transcranial direct current stimulation gait dual-task
entire papilla preservation technique in the treatment of periodontal intrabony defects: a 1-year follow-up study

Conditions: Periodontal Diseases; Periodontal Bone Loss

Summary: the aim of this study was to investigate the radiographic and clinical outcomes associated with the whole papilla preservation technique in the treatment of isolated intraosseous defects in patients with stage iii periodontitis. the records of 17 systemically healthy patients (12 women and 5 men) diagnosed with stage iii periodontitis who underwent the whole papilla preservation technique three months after nonsurgical periodontal treatment were evaluated. the following clinical parameters were recorded at baseline and after treatment: full mouth plaque score (fmps), full mouth bleeding score (fmbs), probing depths (pd), clinical attachment level (cal) and gingival recession (gr). the early healing index (ehi) score was assessed 1 week after surgery in both groups. cal gain was determined as the primary outcome. baseline data as well as follow-up assessments at 1 month, 3 months, 6 months and 1 year were analyzed to determine the efficacy and long-term outcomes of the treatment.


Eligibility criteria:
inclusion criteria: * • systemically healthy individuals. * patients who underwent reconstructive periodontal surgery following the completion of non-surgical treatment. * presence of at least one isolated two- or three-wall intrabony defect with probing depth (pd) ≥7 mm, clinical attachment level (cal) ≥7 mm and at least 4 mm intrabony component involving predominantly the interproximal area of the affected tooth * full-mouth plaque score (fmps) and full-mouth bleeding score ≤20% exclusion criteria: * individuals who smoke * individuals with uncontrolled systemic disease * individuals using drugs that affect periodontal tissues * individuals during pregnancy and breastfeeding * presence of single-walled intraosseous defects * flood restoration * inadequate endodontic treatment

Keywords: microsurgery clinical attachment level
a neuroprosthesis for seated posture and balance

Conditions: Spinal Cord Injury; Paralysis; Tetraplegia; Paraplegia

Summary: the purpose of this study is to evaluate a surgically implanted functional electrical stimulation (fes) system to facilitate stability of the trunk and hips. fes involves applying small electric currents to the nerves, which cause the muscles to contract. this study evaluates how stabilizing and stiffening the trunk with fes can change the way spinal cord injured volunteers sit, breathe, reach, push a wheelchair, or roll in bed.

in a single surgical procedure electrodes will be inserted into muscles of the trunk and hip musculature. the electrode leads are connected to a stimulator/telemeter located in the abdomen. after a typical post-operative period of two to five days, neuroprosthesis recipients will be discharged to home for two to six weeks of restricted activity to promote healing of all surgical incisions. after a period of exercise and training, functional use of the neuroprosthesis will begin. laboratory assessments of strength, balance, and functional abilities with and without the system, as well as the technical performance of the implanted components will be evaluated.

Eligibility criteria:
inclusion criteria: * c4-t12 * asia scale a through c * time post injury greater than 6 months * innervated and excitable trunk and pelvis musculature * absence of acute or chronic psychological problems or chemical dependency * range of motion within normal limits * controlled spasticity and absence of hip flexion and adduction spasm * height and weight within normal limits * no history of balance problems or spontaneous falls * no history of spontaneous fracture or evidence low bone density * no acute orthopaedic problems * no acute medical complications * adequate social support and stability * able to speak and read english exclusion criteria: * pregnancy * non-english speaking

Keywords: paraplegia tetraplegia spinal cord injured fes
effects of decision aids on the participation of south asian women in cervical cancer screening

Conditions: Cervical Cancer

Summary: objectives: to examine the effects of linguistically appropriate decision aids on decisional conflicts, risk perception, clarity of values, screening decisions and screening uptake among south asian women in hong kong design and subjects: a randomised controlled trial. a sample of 270 south asian women aged 25-64 will be recruited to one of the two intervention groups or control group. instruments: a survey will be conducted to collect data on the variables of concern (decisional conflicts, risk perception, clarity of values, screening decision and screening uptake). interventions: ethnically match community health workers (chws) will deliver the printed or mobile application decision aids to intervention group participants and briefly explain how to use the decision aid. the participants will choose a time and place of their convenience to read the decision aid. the participants will be contacted by chws within 2 weeks and asked if they have experienced any problems. navigation assistance will be given as requested. main outcome measures: decisional conflicts, risk perception, clarity of values, screening decision and uptake. data analysis: the repeated-measure outcomes of risk perception, clarity of values, decisional conflicts and screening decision will be compared between the three groups while adjusting for the stratifying variable (ethnicity) using a generalised estimating equation model, and a multivariable logistic regression with adjustment for ethnicity will be used to compare the screening uptake of the three groups. expected results: the decision aid will clarify the participants' values and help them to make screening decisions and increase the uptake.


Eligibility criteria:
inclusion criteria: 1. indian, pakistani or nepalese; 2. aged 25 to 64; 3. no history of cervical cancer or total hysterectomy; 4. have a history of sexual activity; 5. cannot understand chinese but can read or communicate in english, hindi, urdu or nepali; 6. have not had a pap/hpv test in the past 3 years; 7. have and are willing to use a smartphone in this intervention. exclusion criteria: * na

Keywords: cervical cancer screening south asians ethnic minority decision aid
devenir: defining vulvovaginal candidiasis - elements of infection and remedy

Conditions: Vulvovaginal Candidiasis

Summary: female-specific health conditions are underrepresented in research. the taboo felt by women to talk about intimate wellbeing is fed by this gender gap in scientific knowledge. this project aims to meet these needs by studying one of the most prevalent female-specific infections, vulvovaginal candidiasis (vvc), and paving the way towards its efficient diagnosis and treatment. about 70% of women worldwide suffer from vaginal candidiasis at least once in their life. an episode of this fungal infection is accompanied by a burning sensation, pain, and reduced mental well-being. some women (about 5%) encounter such infections at least four times a year, referring to recurrent(r) vvc. the design of efficient diagnostic and therapeutic strategies for (r)vvc is hindered by a knowledge gap surrounding vaginal health. to meet the absolute need for more information, this project will characterize the role of the microbiome, metabolome, immune system, and pathogen characteristics in (r)vvc. to this end, a large sampling platform of women with/without vvc will be established in this project. the researchers will identify the most important and clinically relevant microorganisms, metabolites, and immune factors in vvc pathogenesis. vvc models will be developed and optimized, which will be used to validate the causality of the correlations identified in the cohort. identified correlations will be proposed as biomarkers, and microbes, metabolites, and combinations, which effectively lower the pathogenicity of candida species, will be further investigated for therapeutic potential. state-of-the-art tools and know-how of the researchers will allow the unraveling of the involved molecular pathways and elucidate how these can be exploited to optimize therapeutic efficacy. finally, the knowledge gathered in this project will be used to improve the literacy of women on vvc using platforms established by the researchers as well as novel tools to be developed in this project.


Eligibility criteria:
inclusion criteria: * female * age: 18-50 * premenopausal exclusion criteria: * pregnancy * self-reported vaginal complaints (e.g. redness, itching, pain, burning sensation, abnormal vaginal discharge) in the past 12 months (only for healthy group) * use of antibiotics/antifungals in the month prior to sample collection (only for healthy group)

Keywords: microbiome innate immunity mycology infectious diseases
incretin action in physiology and diabetes

Conditions: Insulin Secretion

Summary: this project is designed to advance understanding of the incretin effect in health and disease. this system of gut-islet linkage is essential for normal glucose tolerance, impaired in t2dm, and amenable to therapeutic intervention. however, there are important gaps in understanding incretin function that limit application of this system; this project will address several of these. a secondary, but critical aspect of this research is focus on inter-individual variation in the physiology of the incretin system. this is a novel direction for research in this field and is critical to advancing the concept of individualized medical care in diabetes by establishing whether there is a physiologic basis for predicting the existence of responders and non-responders to incretin therapies. currently, we have described only aim 1 from this grant in this protocol registration. while aim 2 and 3 are described in the grant, aim 1 will be conducted first and the results from this aim and / or the publication of other results in the field may affect the approach to aims 2 and 3.


Eligibility criteria:
inclusion criteria: * healthy adult volunteers * fasting plasma glucose value ≤ 95 mg/dl, measured at screening visit * hba1c ≤ 5.9%, measured at screening visit exclusion criteria: * history of diabetes diagnosis, including gestational diabetes * presence of type ii diabetes mellitus among any first degree family members * rheumatoid arthritis * inflammatory bowel disease * unstable angina or uncompensated heart failure * pulmonary disorders including copd and asthma * malabsorptive gi disease, such as celiac disease, or gastric bypass * significant hepatic disease * renal insufficiency (egfr \< 60 ml/kg/min) * anemia (hematocrit \< 34%) as measured at screening visit * pregnancy * uncontrolled hypertension * consumption of daily medications that alter glucose metabolism or gi function (glucocorticoids, psychotropics, narcotics, metoclopramide)

Keywords: incretins glp-1 gip hyperglycemic clamp glucagon
tumors of the peripheral nervous system

Conditions: Tumor of Peripheral Nerve

Summary: the goal of this observational study is to individuate tumors' and patients' features influencing the outcome after surgical tumor removal.

patients operated because of removal of peripheral nervous system (pns) tumor will be recruited accordingly to the inclusion criteria: the aims of the study will be illustrated and the informed consent signed. all the clinical and neuroradiological perioperative documents of the enrolled patients will be analyzed. as follow-up, thorough neurological exam wil be performed and specific surveys about after surgery social and working life will be administered; neuroradiological imaging will be performed. then, the results will be investigated to individuate which factors were related to the outcome.

Eligibility criteria:
inclusion criteria: * ≥ 18 y.o. * neurosurgical removal of peripheral nerve tumor at our university hospital "fondazione policlinico universitario agostino gemelli (fpg)" during the previous 10 years * signed consent to study participation exclusion criteria: * \< 18 y.o. * neurosurgical treatment because other causes (chronic entrapment syndromes, acute nerve lesion) * denied consent to study participation

Keywords: outcome, neurosurgery