Kornimate/medical-research-clean huggingface dataset:
evaluation of a connected parenteral pump for patients treated by home parenteral nutrition (hpn).

Conditions: Parenteral Nutrition, Home

Summary: patients requiring long-term home parenteral nutrition (hpn) suffer from chronic intestinal insufficiency. the causes of this syndrome can be either anatomical (extensive resection of the small bowel) or functional (occlusion, pseudo-occlusion, malabsorption). consequences mean that patients are unable to cover their oral energy and / or hydroelectrolytic needs. as a result, these patients survive only through a nutritional support by the venous route (parenteral nutrition). however, this lifesaving therapy requires complex technological nutritional support issues at home, which will influence the personal life of the patients. at home, hpn therapy is performed by nutrition pumps providing a constant flow and able to detect anomalies. in this context, the development of connected systems that allow informations transmission could help patient's caregiving by the different persons involved in his follow-up (prescribing physicians, home support nurses, patients and relatives, manufacturers). the main objective of this study is to evaluate the performance of an end-to-end data transmission chain which integrates a nutrition pump connected to a medical iot module (developped by maatel) able to send information to an applicative layer (software interface pathview2, developped by orange labs) via different transmission modes : lorawan (long range wide-area network), ble (bluetooth low energy), gsm lte-m (global system for mobile communications, long term evolution - machine type communication).


Eligibility criteria:
inclusion criteria: * age \< 18 years * patient receiving a home parenteral nutrition (hpn) and followed by the artificial nutrition service of the chuga * patient carrying out all his infusions at home during the month of use of the connected pump (constraint due to the lorawan transmission mode) * patient affiliated to the french social security system or an equivalent system * patient who has signed consent form exclusion criteria: * presenting any other pathology or treatment that the physician may deem incompatible with this study * patient under exclusion period from another study * protected persons (patient concerned by articles l1121-5, l1121-6, l1121-8 of the french public health code)

Keywords: connected feeding pump reduction of costs due to late management of complications patients quality of life improvement clinical management of patients' pathology improvement
effects of heat and moisture exchanger in combination with air forced warming blankets or warming intravenous solutions on intraoperative hypothermia prevention in obese and non obese patients during intravenous anesthesia

Conditions: Hypothermia

Summary: the aim of the present study was to evaluate if the combination of heat and moisture exchanger with air forced warming blankets or warming intravenous fluids prevents intraoperative hypothermia in obese and non obese women under target controlled infusion-total intravenous anaesthesia (tci-tiva) during lower abdominal surgery.


Eligibility criteria:
inclusion criteria: * women * 18-65 years old * gynecologic * obesity exclusion criteria: * fever * endocrine disease * hypertension * vasoactive drugs

Keywords: hypothermia obesity heat and moisture exchanger warming blanket warming fluids gynecological surgery intravenous anesthesia obese patients non obese patients
assessment of prokinetic effects of erythromycin in emergency patients with a full stomach

Conditions: Emergency Surgery; Full Stomach

Summary: the aims of the study is to assess whether the intravenous infusion of 3 mg/kg erythromycin has a significant gastrokinetic effect leading to empty the stomach in less than 90 minutes in non-fasting patients undergoing emergency trauma surgery.


Eligibility criteria:
inclusion criteria: * emergency surgery for trauma * asa 1 and 2 patients * full stomach (antral area \> 550 mm²) * adult patients exclusion criteria: * no contraindication to erythromycin * extreme emergency surgery (time frame \< 90 min between arrival in the service and the start of the surgery) * gastroparesis or pathology associated with gastroparesis
continuous local infusion of anesthetic at the incisional site for scoliosis surgery

Conditions: Scoliosis

Summary: the purpose of this study is to evaluate the effects of continuous local anesthetic delivery on the immediate post-op recovery of patients undergoing spinal fusion surgery for congenital or idiopathic scoliosis.

constant local analgesic infusion is a relatively new modality that provides a constant supply of medication without the need for repeat injections. this method has shown encouraging results with respect to pain levels, narcotic use, faster rehabilitation and shorter hospital stay in patients undergoing laparotomies, iliac crest bone graft harvest, and sternotomies. in addition, there have not been any reported complications when used in these scenarios. we hope to confirm better pain control, less narcotic use (i.e. pca), fewer narcotic side effects, better response to physical therapy and earlier discharge. which may be generalized to the spinal surgery patient population as less pain and suffering and a better overall hospital course

Eligibility criteria:
inclusion criteria: * clinical diagnosis of congenital scoliosis * clinical diagnosis of idiopathic scoliosis * anticipated spinal fusion surgery exclusion criteria: * less than 8 years of age

Keywords: congenital scoliosis idiopathic scoliosis spinal fusion post-operative pain management infusion catheter
a pilot study of tdcs for mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: the primary objective of this preliminary study is to investigate whether the transcranial direct current stimulation (tdcs) improves the cognitive function in patients with mild cognitive impairment (mci)

twenty patients were recruited and randomized to receive either real or sham-tdcs over the left (anode) and right (cathode) dorsolateral prefrontal cortex (dlpfc). patients or their legally responsible caregivers were provided with mobile tdcs device, and were instructed to use it at home. 30-minute session of the stimulation were applied everyday in the morning for 12 weeks. the patients were evaluated at baseline, at week 6 and 12.

Eligibility criteria:
inclusion criteria: * subjects who have a subjective memory impairment * subjects who have korean version of mini mental status examination score 24 or more * subjects who have svlt and rcft delayed recall test scores lower than 1.5sd * subjects who have had other cognitive impairments besides memory * subjects with late amnestic mild cognitive impairment, verbal and visual memory impairment and multiple domain problem * subjects who have seoul-instrumental activities of daily living score (s-iadl) of 8 or lower * subjects who are right-handed * subjects who are able to read and write * both subject and legally responsible caregiver have provided informed consent * according to the latest mri result, periventricular white matter cap or band is less than 10mm, or the deep white matter hyper-intensity is less than 25 mm exclusion criteria: * subjects who have a history of stroke and seizures * subjects who have any illnesses that may disturb the patients completing the trials, including stroke, parkinson's disease, type 1 diabetes, uncontrollable high blood pressure, huntington's disease, cerebral palsy, liver failure, nephritis, encephalitis, meningitis, scleroma, seizures and a transient ischemic attack. * subjects who have neurologic problems on physical examination that cause memory disturbances * subjects who have a history of dsm-iv axis i disorders * subjects who have extremely sensitive skin * subjects who have suffered from the cancer in 3 years * subjects who have had a cerebrovascular neurosurgery in medical history * subjects who have dyspnea in sitting position * subjects who have problems with memory, language and problem-solving for 2 hours after the heart attack. * subjects who have a history of drug or alcohol abuse (in the past 5 years) * subjects who have a history of mental or emotional disorders (in the past 5 years) * subjects who have been lapsed into unconsciousness for an hour because of other reasons than general anesthesia * subjects who have a history of hospitalization due to head injury * subjects who are unable to read even with glasses * subjects who are unable to understand the conversation due to the hearing defect (even with the hearing aid)

Keywords: mild cognitive impairment mci tdcs transcranial direct current stimulation
is hemodialysis associated with cardiac markers change?

Conditions: Renal Insufficiency, Chronic

Summary: hemodialysis (hd) triggers recurrent and cumulative ischemic insults to the brain and the heart. cooled dialysate may have a protective effect on major organs and improve hemodynamic tolerability of dialysis. the aim of the study was to compare hd with cooled dialysate with routine dialysis in terms of hemodynamic stability and levels of high sensitivity troponin i (hs-tni) and n-terminal pro b-type natriuretic peptide (ntprobnp) post dialysis


Eligibility criteria:
inclusion criteria: * patients with renal insufficiency treated with dialysis for a period of at least three months. exclusion criteria: * patients who experienced myocardial infarction during the three months prior to the start of the study * patients who underwent vascular surgery during the last month * patients who experienced chest pain at rest during the last week before the start of the trial - patients who had to discontinue dialysis prematurely due to hemodynamic instability.

Keywords: end-stage kidney disease hypothermic hemodialysis cardiovascular events troponin t brain natriuretic peptide
efficacy of post-operative antibiotic prophylaxis for thoracic surgery requiring tube thoracostomy

Conditions: Antibiotic Prophylaxis

Summary: the purpose of this study is to evaluate if post-operative antibiotic prophylaxis decreases infectious complications when compared to pre-operative antibiotics alone, in patients undergoing elective thoracic surgery requiring tube thoracostomy (chest tube).

there is currently no evidence-based standard for the extended use of prophylactic antibiotics in patients receiving thoracic surgery that results in the placement of a tube thoracostomy (chest tube). the rationale for this prophylaxis is that antibiotics directed at typical skin flora may reduce the rate of infectious complications, such as surgical site infection and empyema. currently, clinicians' approach to post-operative antibiotic prophylaxis in patients undergoing tube thoracostomy associated with thoracic and cardio-thoracic surgery varies widely. while reducing the infectious complications of thoracic surgery is an important goal, it is also important to reduce the use of unnecessary antibiotics. as there is equipoise on the benefit of extended antibiotic prophylaxis for tube thoracostomy, our study will examine two prevailing clinical practices and attempt to determine if one leads to better patient outcomes.

Eligibility criteria:
inclusion criteria: * adults aged 18 years or older undergoing elective thoracic surgery at brigham \& women's hospital. the majority of these patients will be undergoing lung resection for either the evaluation of a lung mass, or for the removal of a known malignancy. some participants may be undergoing biopsy or removal of a mediastinal mass. * undergoing thoracic surgery procedure expected to require tube thoracostomy. * ability to give informed consent exclusion criteria: * patients undergoing the following complex thoracic surgical procedures: * pneumonectomy * decortication * chemical pleurodesis * pleurectomy * lung volume reduction * esophagectomy * patients with the following conditions: * prior diagnosis of empyema or lung abscess. * cystic fibrosis * known or suspected pneumonia pre-operatively. * known hypersensitivity to beta-lactam antibiotics and vancomycin * current or recent antibiotic use within one week of surgery. * anticipated requirement for postoperative antibiotic in addition to 48 hours of cefazolin or vancomycin. * renal insufficiency with estimated creatinine clearance \<60 ml/minute.

Keywords: thoracic surgery antibiotic prophylaxis chest tube
delft (dynepo evaluation of long-term follow-up treatment)

Conditions: Anemia; Kidney Diseases; Renal Failure, Chronic; Kidney Failure, Chronic

Summary: this is a post-authorisation safety study to assess the incidence and severity of all pre-defined cardiovascular events in patients treated with dynepo, as well as to detect \& describe less common adverse drug reactions, and to summarise dynepo drug utilisation.


Eligibility criteria:
inclusion criteria: * adult patients must have established chronic kidney disease (ckd) and be willing and able to provide written informed consent. * patients must already be receiving dynepo treatment at time of study entry. * patients who are likely to receive dynepo for at least 1 year. exclusion criteria: * known intolerance to epo of any of its excipients * known of suspected pure red cell aplasia (prca)
evaluation of blood as a submucosal cushion during endoscopic polypectomy and mucosal resection

Conditions: Large Polyps in the Gastrointestinal Tract

Summary: for removal of large flat lesions of the gastro-intestinal tract injection of a solution under the lesion creates a "safety" cushion and protects from damage to the gastrointestinal tract wall. various solutions are currently used, but some of them are easy to inject but quickly dissipate (normal saline),other solutions are more longer lasting (hydroxypropyl methylcellulose, hyaluronic acid, etc) but are very difficult to inject and can be expensive and not always available. the investigators performed previously animal experiments which demonstrated that blood is easy to inject and creates a protective cushion which lasts longer than other fluids which are currently used for protective cushion creation.

for removal of large flat lesions of the gastro-intestinal tract injection of a solution under the lesion creates a "safety" cushion and protects from damage to the gastrointestinal tract wall. various solutions are currently used, but some of them are easy to inject but quickly dissipate (normal saline),other solutions are more longer lasting (hydroxypropyl methylcellulose, hyaluronic acid, etc) but are very difficult to inject and can be expensive and not always available. the investigators decided to use blood drawn from the patient for injection under the lesion. the investigators performed previously animal experiments which demonstrated that blood is easy to inject and creates a protective cushion which lasts longer than other fluids which are currently used for protective cushion creation. blood can also have local hemostatic action preventing from bleeding during polypectomy.

Eligibility criteria:
inclusion criteria: * polyps equal or larger than 1 cm exclusion criteria: * coagulopathy * inability to sign informed consent

Keywords: submucosal cushion polypectomy endoscopic mucosal resection
evaluation of the diagnostic utility of ins316 in patients with interstitial lung diseases (01-701)

Conditions: Interstitial Lung Disease

Summary: the objective of the present work is to explore and compare the diagnostic quality of sputum specimens obtained by bal, induction with hypertonic saline (3%), and induction with ins316 in patients diagnosed with interstitial lung diseases.


Eligibility criteria:
inclusion criteria: * between 18 years or older * undergone diagnostic bronchoalveolar lavage within the previous 21 days * diagnosed with sarcoidosis or other ild exclusion criteria: * having resting hypoxemia * receiving corticosteroid treatment
innovations in respiratory muscles training in patients with chronic obstructive pulmonary disease. (innotorio)

Conditions: COPD; Respiratory Muscles; Training

Summary: respiratory muscle weakness and fatigue are related to clinical deterioration in patients with chronic obstructive pulmonary disease (copd). respiratory muscle training (rmt) is a key therapeutic strategy in these patients. it is necessary therefore to increase its dissemination on a large scale, improve patient´s adherence and optimize the control of the implementation of training. the aim of this project was to design a rmt device including light and sound incentives, digital registration application and analysis of the training sessions, and studying the effectiveness of a new shortened rmt scheme of high intensity that could provide added value to enhance the implementation of training in patients with copd. from an operational point of view, researches were organized into three packages of complementary work focused on the design of a new portable dual valve with electronic lighting and auditory incentives components. the conceptualization and design of a software to analyze the performance and individual continuous use of the valve, and the evaluation of the feasibility, safety and efficacy of a shortened schedule of respiratory muscle training in adult patients with copd were realized.


Eligibility criteria:
inclusion criteria: * clinical diagnosis from moderate to severe copd muscle weakness inspiratory must be able to do exercises exclusion criteria: * positive bronchodilator response cardiovascular, neuromuscular, or metabolic disease hospital admission for any pathology in the last two months have completed a rehabilitation program in the last year
me and the others: expectations and evaluation of social relationships

Conditions: Life Change Events; Loneliness

Summary: chronic and pervasive loneliness has been identified as an important factor in the relationship between adverse childhood experiences (ace) (e.g. abuse and neglect) and mental disorders. however, the mechanisms determining loneliness after ace are still needed to be disentangled. therefore, this study aims to investigate the differential effect of ace on alterations in cognition and the link between ace and loneliness with an emphasis on the effect of type and timing of ace.

with the rationale of the detrimental effects of loneliness on mental and physical health may be based on the interactions between genetic predispositions and social-environmental influences (e.g. ace) via affecting neurobiological and cognitive processing, goals of this project are 1) characterization of loneliness to understand whether people suffer from mental/somatic disorders, feel lonelier and this effect is particularly strong in those with a history of ace, 2) understanding the determinants of chronic loneliness by investigating certain personality dispositions such as rejection sensitivity and justice sensitivity, genetic predisposition for loneliness and social environments during childhood and adolescence and 3) inquiring into the social-cognitive correlates of these potential determinants in people's life today

Eligibility criteria:
inclusion criteria: * healthy individuals with and without adverse childhood experiences + clinical control group (i.e. individuals with borderline personality disorder) exclusion criteria: * a lifetime history of psychotic or bipolar i disorders, current pregnancy, history of organic brain disease, skull or brain damage, or severe neurological illnesses.

Keywords: childhood adversities childhood neglect childhood abuse rejection sensitivity justice sensitivity loneliness
study to evaluate the safety, tolerability of bcx9930 in participants with either complement 3 glomerulopathy (c3g), immunoglobulin a nephropathy (igan), or primary membranous nephropathy (pmn)

Conditions: Complement 3 Glomerulopathy; Immunoglobulin A Nephropathy; Membranous Nephropathy

Summary: the objective of this study was to determine the safety and therapeutic potential of bcx9930 in participants with c3g, igan, or pmn.


Eligibility criteria:
inclusion criteria: * body weight ≥ 40 kilograms (kg) * primary diagnosis of c3g, igan, or pmn confirmed by central pathology review * an estimated glomerular filtration rate (egfr) ≥ 50 milliter per minute per 1.73 meter square (ml/min/1.73 m\^2) (or ≥ 30 ml/min/1.73 m\^2 after data monitoring committee \[dmc\] recommendation) * receiving treatment with a stable, maximum recommended or maximum tolerated dose of an angiotensin-converting enzyme inhibitor (acei) or angiotensin receptor blocker (arb) for at least 60 days prior to the day 1 visit * documentation of current vaccinations against neisseria meningitidis and streptococcus pneumoniae or willingness to start vaccination series exclusion criteria: * known congenital deficiency of c1s, c1r, c1q, c2, or c4 * history of hematopoietic cell transplant or solid organ transplant or anticipated candidate for transplantation * myocardial infarction or cerebrovascular accident within 30 days prior to screening, or current and uncontrolled clinically significant cardiovascular or cerebrovascular condition * history of malignancy within 5 years prior to the screening visit * active serious bacterial, viral, or fungal infection or any other serious infection within 14 days of screening * treatment with any systemic immunosuppressive or immunomodulatory therapy within 90 days or anti-cd20 antibody therapies (eg, rituximab) within 180 days prior to the screening visit * treatment with renin inhibitors (eg, aliskiren) or sodium-glucose-cotransporter 2 (sglt2) inhibitors within 60 days prior to day 1

Keywords: bcx9930 factor d inhibitor oral therapy complement 3 glomerulopathy immunoglobulin a nephropathy primary membranous nephropathy
critical health assessment and outcomes score/study

Conditions: Critical Illness; Death, Sudden

Summary: chaos is based on the investigator's new and exciting results from pre-clinical and large longitudinal multi-center observational clinical studies of critically ill patients and asymptomatic community-based adults with little or no advanced disease. by integrating approaches from the physical, biological, computational, statistical and clinical sciences, this observational study will test the hypothesis that early diagnosis of subclinical signatures of critical illness encoded within physiological signals complements conventional clinical predictors by providing unique prognostic insight. the primary goal is to reduce mortality, morbidity and complications by early identification of individuals with brewing subclinical critical illness and adverse events before overt clinical presentation (e.g., cardiac arrest, arrhythmias, hemorrhage, respiratory failure, circulatory collapse). this will provide the necessary lead time for healthcare providers to deliver early, more effective and/or preventive therapies. through innovative approaches, chaos also meets the challenge of medical errors to reduce missed diagnosis, misdiagnosis, preventable harm and variability in provider adherence to best practice guidelines. the goal is to validate predictive algorithms and identify subclinical signatures of illness, ranging from asymptomatic adults in the community to very sick patients in the hospital. the overall goal is to make healthcare more precise, effective, efficient, safe and timely while reducing costs, preventable harms and adverse events.


Eligibility criteria:
inclusion criteria: * all patients age 18-100 years admitted to a bed or or with telemetry monitoring capability will be included. exclusion criteria: * children (individuals \<18 years of age).