Kornimate/medical-research-clean huggingface dataset:
impact on postoperative wellbeing in the post-anaesthesia care anaesthesia (pacu) of personalized music and beverages.

Conditions: Postoperative Complications; Postoperative Pain

Summary: postoperative disturbances for patients' well-being in the pacu after general or spinal anaesthesia will be assessed. influence of the offer of beverages and music will be assessed regarding their wellbeing, satisfaction and pain.


Eligibility criteria:
inclusion criteria: * elective stationary adult patients capable and willing of filling out the questionnaire exclusion criteria: * participation in other studies about wellbeing influence * incapability of filling out the questionnaire * patients that do not wish to participate

Keywords: wellbeing postoperative pain postoperative disturbances after anaesthesia
evaluation of relationship between hypersexuality and psychostimulant among men who have sex with men

Conditions: Psychoactive Substances Consumers

Summary: survey of fifty new psychoactive substances consumers in a context of mtm sexual intercourse. evaluation using an hetero-assessment questionnaire about the link between hypersexual disorder and the use of synthetic cathinone. evaluation on psychoactive drug addiction, the induced or pre-existing sexual practices and the medico-psycho-social consequences of those practices.


Eligibility criteria:
* inclusion criteria: * patients ≥ 18 years * male homosexual and / or bisexual who come to the csapa at the croix-rousse hospital, lyon france following the use of psychostimulants products in sexual contexts * patients who have received clear information and not opposed to participate in the study * patients affiliated to a social security scheme or similar * patients not undergoing a measure of legal protection * exclusion criteria: * opposition to participation in the study * patients \< 18 years * pregnant women or breastfeeding * deprived of individual liberty

Keywords: addiction hypersexuality psychostimulants
treatment of acute hiv infection to preserve immune function

Conditions: HIV Infections

Summary: while most people with hiv experience significant destruction of their immune systems, some people appear to have preserved immune function and can control the virus without drugs. early treatment with anti-hiv drugs may help preserve the immune system, allowing it to control the virus once the drugs are stopped. this study will evaluate the immune system response of hiv infected people who are treated with anti-hiv drugs soon after being infected.

studies have identified a potent cd4 t helper (th) cell response in some infected people, and have shown a correlation between virus-specific th cells and low levels of viremia. early institution of potent antiviral therapy in the earliest stages of acute hiv infection have led to strong th cell responses, analogous to those seen in people who are able to control viremia in the absence of antiviral therapy. this may be because potent antiviral therapy is able to protect virus-specific th cells as they become activated, and thus these cells are not lost in the earliest stages of infection. this study will characterize the immune response of patients with acute hiv infection who receive antiretroviral therapy and will determine the effects of interruption of therapy in those people who have immune responses to hiv that are similar to patients with long-term non-progressing infection. participants in this study will be followed through june 2004. study visits vary from only once to every month and are scheduled at the discretion of the study officials. study visits include an interview and blood tests.

Eligibility criteria:
inclusion criteria * acute hiv infection

Keywords: immune system helper t-cells acute infection treatment naive
vaginoscopy compared to traditional hysteroscopy for hysteroscopy morcellation in outpatient clinic. a randomized trial

Conditions: Leiomyoma of Uterus

Summary: this study is a randomized controlled trial take place in a fertility outpatient clinic in an academic hospital. women between 18 and 52 years old requiring polypectomy or myomectomy by hysteroscopy morcellation for abnormal uterine bleeding or for fertility issue are included. the aim is to evaluate pain perception between vaginal and traditional hysteroscopy for hysteroscopic morcellation. the investigator's hypothesis is that pain perception is lower using vaginoscopy compared to traditional hysteroscopy.

78 participants will be randomised in two groups: 1. traditional hysteroscopy: under intravenous sedation, hysteroscopic morcellation is perform after speculum insertion, vaginal cleansing, and paracervical anesthesia with xylocain 1%. 2. vaginal hysteroscopy: under intravenous sedation, hysteroscopic morcellation is perform after vaginal cleansing using vaginal distension with saline solution in addition to pain perception, other outcomes includes: complication rates, time to continue fertility treatment, time to pregnancy

Eligibility criteria:
inclusion criteria: * polyp or fibroid previously diagnosed by hysteroscopy * polyp less than 2 cm * submucosal fibroid (type 0 or 1 according to the 2011 figo uterine fibroid classification) less than 2 cm * if more than 1 fibroid: total fibroid have to be less or equal 4 cm exclusion criteria: * cervical stenosis * polyp or fibroid more than 2 cm * pregnancy * blood dyscrasia

Keywords: vaginoscopy hysteroscopy morcellation infertile population
the efficacy of implementing nurse-performed ultrasound-guided peripheral intravenous access in oncology patients

Conditions: Supportive Care

Summary: the purpose of this study is to investigate the clinical efficacy of nurse-performed ultrasound-guided intravenous access in oncology patients on the oncological outpatient unit in the national hospital of the faroe islands.

this project is prospective, interventional, clinical study aligned in four different time stages. in the first stage, the pre-implementation stage, procedures are as usual, where the patient receives intravenous access via the use of the traditional palpation technique and data will be registered. in the next stage, the training stage, the nurses on the oncological outpatient unit will be trained in the use of the ultrasound-guided technique to place peripheral intravenous catheters and will be supervised by specialists in ultrasound. in the third stage, the implementation stage, the nurses will use the ultrasound technique as a daily routine in their practice. in the fourth stage, the post-implementation stage, the same data registration as in the first stage will be registered (see outcome measures) and the results will be compared in order to see the efficacy before and after implementation of ultrasound guidance. it is estimated a total sample of 100 cannulation procedures with approximately 30 patients needed in the pre-implementation and post-implementation stages.

Eligibility criteria:
inclusion criteria: * cancer patients admitted to the oncological outpatient unit are eligible for inclusion if they are scheduled for treatment with chemotherapy requiring placement of peripheral intravenous catheter, aged 18 years or older, and reside in the faroe islands. exclusion criteria: * lack of informed consent and mental incapacity.

Keywords: ultrasonography intravenous oncology
silver diamine fluoride(sdf) versus sdf combined with sodium fluoride varnish in the arrest of early childhood caries

Conditions: Early Childhood Caries

Summary: early childhood caries (ecc) is the most common chronic childhood disease worldwide. early restorative intervention may treat the disease but this is often difficult especially with uncooperative children so it may be left untreated. remineralization of affected dentin using silver diamine fluoride (sdf) can arrest these lesions. this trial aims to compare the effectiveness of 38% sdf solution versus 38% sdf solution with 5% sodium fluoride (naf) varnish after six months in arresting ecc lesions.


Eligibility criteria:
inclusion criteria: 1. children ≤ 4 years old. 2. the presence of at least one carious lesion on a primary tooth, with scores 3 and higher (according to the international detection and assessment system- icdas ii, appendix 1, table 1), detected by visual examination. 3. the carious lesion has to be active according to lesion activity criteria of coronal caries of icdas ii. 4. parental consent for children's participation in the study. exclusion criteria: 1. children reporting spontaneous or elicited pain from caries, or showing any signs of pulpal infection, swelling and/or abscess. 2. children showing a definite negative behavior (score 1 frankel's classification) during clinical examination. 3. allergy or sensitivity to silver or any of the materials included in the study.

Keywords: ecc sdf 38% naf 5% preschoolers
activation of cervical and upper thoracic brown adipose tissue in humans via beta-adrenergic stimulation

Conditions: Obesity

Summary: in this study the investigators aim to quantitate the extent of cervical and upper thoracic brown adipose tissue (bat) activation in lean and obese humans via positron emission tomography-computed tomography (pet-ct) in response to the non-specific beta adrenergic receptor (ar) agonist ephedrine. the investigators hypothesise that this pharmacological adrenergic stimulus will result in activation of bat in these participants, and that this activation will be reduced in obese patients. this study will provide important preliminary information with respect to allowing the investigators to progress with longer trials with specific beta 3 ar agonists.


Eligibility criteria:
inclusion criteria: healthy group * males aged 20 - 40 years * free of overt coronary disease (on history, medical examination and ecg) * fasting plasma glucose \< 6.1 mmol/l and 2 hour ogtt glucose \< 7.8 mmol/l * unmedicated * no major illness * bmi 18 - 25 inclusion criteria: obese group * males aged 20 - 40 years * free of overt coronary disease (on history, medical examination and ecg) * unmedicated * no major illness * bmi 30+ * weight \< 100 kg * height \< 185 cm the inclusion criteria (obese participants) of body weight less than \~100 kg is implemented as the pet-ct scanner to be utilised (protocol described subsequently) has a limited patient volume. therefore to fit within the criteria of bmi \> 30, only patients of height \~183 cm or less can be recruited, and inclusion of borderline participants will be discussed with co-investigators from the alfred hospital nuclear medicine department. exclusion criteria: healthy group * unable to give informed consent * smokers * lactose intolerance exclusion criteria: obese group * unable to give informed consent * smokers * lactose intolerance * participant in research projects involving ionising radiation within the past 5 years * claustrophobia
competence-feedback and therapy outcome

Conditions: Depression

Summary: in a randomized controlled study design, n = 58 treatments of patients with depression were to be conducted under a feedback-condition, in which the therapist would receive feedback five times within 20 treatment sessions. the competence-feedback includes detailed feedback about 14 different aspects of therapist behavior. the control group includes n = 58 further treatments within which therapists do not receive any competence-feedback (treatment as usual; tau).

psychotherapeutic competencies are considered to be an important factor for therapy success. however, empirical studies which have investigated the competence-outcome relationship were only based on correlational analyses. therefore, these studies are inappropriate for the investigation of causal relationships. in previous studies, feedback on therapists' competencies was found to be suitable for enhancing such competencies. therefore, in the current research project, competence-feedback should be used to enhance therapeutic competencies systematically, in order to investigate the causal impact of these competencies on therapy outcome. using a randomized controlled study design, n = 58 treatments of patients with depression were to be conducted under a feedback-condition, in which the therapist would receive feedback five times within 20 treatment sessions. the competence-feedback includes detailed feedback about 14 different aspects of therapist behavior. the control group includes n = 58 further treatments within which therapists do not receive any competence-feedback (treatment as usual; tau). in order to ensure comparability of both treatment conditions (regarding an observation situation), the therapists in the tau condition should also receive feedback, but only after the treatments are finished. we hypothesize that the feedback-group is superior to the tau-group and that their treatments lead to significantly better therapy outcome. moreover, we use mediator analysis to analyze whether the group-outcome relationship is mediated by therapeutic competencies or by the quality of the therapeutic alliance. the results are highly relevant for clinical process research, psychotherapy training and for the dissemination of treatment approaches in routine care.

Eligibility criteria:
therapists inclusion criteria: * having successfully completed the interim audit * having started to treat ambulant patients exclusion criteria: --- patients inclusion criteria: * clinical diagnosis of major depression (meeting dsm-iv criteria) * informed consent exclusion criteria: * suicidal tendency * clinical diagnosis of alcohol or drug addiction, acute schizophrenia, schizoaffective disorder or bipolar disorder * clinical diagnosis of personality disorder cluster a (odd disorders) and b (dramatic, emotional or erratic)

Keywords: competence-feedback
variability in asd (adult spinal deformity) value

Conditions: Hospital Costs

Summary: the study will examine if variability in created value (outcome/costs) over the care cycle for asd patients can be explained by patient and treatment characteristics.

due to budget restrictions in health care, cost is a major challenge, particularly in chronic disorders affecting the ageing population for which advanced but often expensive medical technologies offer benefit. stakeholders strive to define, assess and improve the so-called "value in healthcare" to achieve the best outcome at the lowest cost of care. first and foremost, the investigator will try to examine if we can explain variability in the created value over the care cycle by patient and treatment characteristics. this knowledge can be used to optimize the value for the patients. also, the investigator will try to compare the psychometric properties between the different versions of value equations, resulting from the use of different outcome tools to measure value. adult spinal deformity patients can take part in the study. this will be decided by clinical examination and radiographic evaluation and is based on at least one of the following criteria: 1) coronal spinal curvature ≥20°, 2)sagittal vertical axis (sva) \>5 cm, 3) pelvic tilt \>25°, 4) thoracic kyphosis \>60°. the patients have to be older than or equal to 18 years old at the time of surgery. in line with the standard of care, the patients will be seen after 3 months, 6 months, 1 year and 2 years postoperatively. pre- and post-operatively, questionnaires will be completed by the patients. the patient questionnaires euroqol 5d (eq-5d-3l and eq-5d-5l) , scoliosis research society 22 score (srs-22), oswestry disability index, core outcome measures index score (comi) and work status will be completed by the patients during the baseline visit and on each follow-up moment at 3 months, 6 months, 1 year and 2 years.

Eligibility criteria:
inclusion criteria: * adult spinal deformity patients * index surgery from 15/03/2020 and 15/03/2022 * age of 18 years old or older at the moment of the index surgery * patients treated in university hospitals leuven * patient has full understanding and is willing to participate (informed consent) exclusion criteria: * • patients younger than 18 years old at the moment of index surgery * patients with an index surgery before 15/03/2020 * patients treated in other centers outside of university hospitals leuven
a trial to evaluate the superior mesenteric vein (14v) lymphadenectomy for distal advanced gastric cancer

Conditions: Gastric Cancer

Summary: this trial is going to evaluate the advantage of d2 radical gastrectomy plus 14v lymph node dissection in 3-year survival rates of advanced gastric cancers.

radical surgery is still the only possible way to cure gastric cancer. in japan, south korea and other countries, due to the popularity of screening and improved surgical procedures, there has been great improvement in overall survival. standard d2 gastrectomy has been the standard operation for advanced gastric cancer. however, there is no unanimous consensus whether standard d2 gastrectomy plus 14v lymph node dissection is needed.till now, it is difficult to stage the 14v lymph node as regional lymph nodes metastasis or distant metastasis. and it is urgent to explore the necessity of 14v lymph node dissection in advanced gastric cancer.so a prospective randomized controlled study will to carry out to evaluate the effects of d2 radical gastrectomy plus 14v lymph node dissection compared with d2 radical gastrectomy.

Eligibility criteria:
inclusion criteria: * curative d2 or d2+ operation had been performed; * physical condition and organ function allows to tolerable abdominal surgery; * willing and able to comply with the program during the study period; * aged 18 to 70 years, preoperative gastric cancer patients with pathologically confirmed; * with more than a 6-month life expectancy; * no other serious concomitant diseases; * no adjuvant chemotherapy before recurrence; * karnofsky performance status scale ≥ 60; * all patients accept 6 cycles xelox chemotherapy regimen exclusion criteria: * pregnancy or breast feeding; * women of childbearing age do not take contraceptive measures; * organ transplantation patients need immunosuppressive therapy; * five years after the trial begin,other malignant tumor occur; * while using other experimental drug or other clinical trials are being; * can not take oral medications; * mentally disordered; * severe recurrent infections were not controlled or with other serious concomitant diseases;

Keywords: gastric cancer d2 lymphadenectomy superior mesenteric vein lymph node
steroid for treatment of acute/subacute severe cerebral venous thrombosis.

Conditions: Cerebral Venous Thrombosis

Summary: the cohort study aims to evaluate the efficacy and safety of steroids combined with anticoagulant therapy compared to standard anticoagulant therapy in acute/subacute severe cerebral venous thrombosis.

background: evidence suggests that the inflammatory response plays a crucial role in regulating severe cvt pathogenesis. however, whether cvt patients can benefit from anti-inflammatory therapy has been debated. objective: the objective of this cohort study is to explore the efficacy and safety of steroids combined with anticoagulant therapy compared to standard anticoagulant therapy in acute/subacute severe cerebral venous thrombosis (cvt) patients. method: we reviewed the data of patients with acute/subacute severe cvt treated with a short-term application of steroid or not from a prospective stroke registry of our center. we compared functional outcomes and major adverse events at 6 months follow-up after discharge.

Eligibility criteria:
inclusion criteria: * acute or subacute severe cvt, determined by the onset-to-admission time (≤ 15 days) or symptom aggravation-to-admission time (≤ 15 days) and mri+mrv/mrbti (mr black-blood thrombus imaging), or ct+ctv exclusion criteria: * younger than 14 years； * foreign nationality； * receiving steroids before the onset of cvt； * patients with other serious diseases； * presenting with neurological deficits before the onset of cvt； * lack of baseline data before treatment； * receiving steroids during hospitalization for other reasons but the dosage did not reach pulsed-therapy level * brain herniation but refusing to undergo decompressive craniectomy, or pupillary light reflex did not recover after decompressive craniectomy

Keywords: cerebral venous thrombosis severe cerebral venous thrombosis steroid therapy
a simple clinical tool to help assess patient volume (fluid) status

Conditions: Sepsis

Summary: patients may have actual or relative intravascular volume depletion in a number of different disease states, particularly with sepsis syndrome. however, it is clinically difficult to determine volume status without invasive monitoring, which may cause unintended complications. our hypothesis is that we can accurately estimate central venous pressure, which is a surrogate marker of volume status, with a noninvasive portable ultrasound device.


Eligibility criteria:
inclusion criteria: * age 18 or older. * healthy, euvolemic volunteers and critically ill patients who are already in an intensive care unit and who will have a central venous catheter placed as part of their planned medical treatment. exclusion criteria: * inability to use ultrasound to measure jugular vein (neck brace or bandage), "code" situation.

Keywords: sepsis intravascular volume ultrasound noninvasive measurement