Kornimate/medical-research-clean huggingface dataset:
evaluating the pharmacokinetic characteristics of ad-101 in healthy volunteers

Conditions: Osteoporosis

Summary: the purpose of this study is to evaluate the pharmacokinetic characteristics of ad-101 in healthy volunteers

this study is to evaluate the pharmacokinetic characteristics and safety of ad-101 compared with administration of raloxifen 60 mg in healthy adults

Eligibility criteria:
inclusion criteria: * healthy adult aged 19 and more at the time of screening visit * body mass index (bmi) between 17.5 kg/m2 and 30.5 kg/m2 at the time of screening visit * no evidence of medical symptoms or signs of congenital or no chronic disease within the last 3 years as a result of medical examination exclusion criteria: * evidence of clinically significant blood, kidney, endocrine, respiratory, gastrointestinal, urinary, cardiovascular, liver, nerve or allergic disease (except for asymptomatic seasonal allergy untreated at the time of administration) * history of gastrointestinal disorders (esophageal ataxia or esophageal strictures, crohn's disease, etc.) or surgery (excluding simple cecal surgery or hernia surgery) that may affect the absorption of drugs * as a result of laboratory tests, the following figures: alt or ast\> 2 times upper limit of normal range
epileptogenic focus localization for children with epilepsy using 18f-fdg pet molecular imaging

Conditions: Epilepsy

Summary: this retrospective study aimed to develop a new approach for automatic localization of epilepsy foci in children with epilepsy.

this retrospective study aimed to develop a new approach for automatic localization of epilepsy foci in children with intractable epilepsy. pediatric patients with intractable epilepsy would be retrospectively included in this study. the inclusion criteria included (1) age between 6 and 18 y; (2) detailed seizure semiology evaluation, mri, eeg and interictal 18f-fdg pet/ct examination; (3) clinical diagnosis as focal epilepsy. the exclusion criteria included (a) any history of central nervous system disease; (b) poor image quality due to head movement.

Eligibility criteria:
inclusion criteria: * 1. age between 6 and 18 years. * 2. detailed presurgical evaluation, including seizure semiology evaluation, mri, eeg and interictal 18f-fdg pet/computer tomography (ct) examination. * 3. clinical diagnosis as focal epilepsy. exclusion criteria: * 1. any history of central nervous system (cns) disease such as trauma and cns tumor. * 2. poor image quality due to head movement.

Keywords: epilepsy peidatrics positron emission tomography (pet)
development of artificial intelligence tools for the detection of stress markers and consideration of stress states in the monitoring of subjects with type 1 diabetes

Conditions: Diabetes Type 1

Summary: stress refers to all the reactions of an organism subjected to exogenous or endogenous stress. in the context of diabetes, stress plays a critical role. there are two forms of stress: acute and chronic, both of which can have a significant impact on patients' glycaemic control. acute stress, if repeated, can cause rapid increases in blood glucose levels, while chronic stress can lead to insulin resistance. it is therefore essential to develop tools for recognising and quantifying stress states specific to patients with diabetes. these tools would provide a better understanding of the role of stress in diabetes management, paving the way for more targeted therapeutic interventions and improving patients' quality of life. we are currently training algorithms using advanced machine learning and artificial intelligence techniques to recognise and quantify stress states using existing databases, including voice and physiological data. these technological advances will make it possible to identify moments of stress more accurately and provide appropriate responses, thereby contributing to better diabetes management. the smart-t1d study is an ancillary study of the evastress study.


Eligibility criteria:
inclusion criteria: * patient who has signed the smart-t1d free and informed consent form * patient able to speak and read french exclusion criteria: * mute patient. * patient with severe speech problems that may prevent voice recordings from being made.

Keywords: stress voice markers glycemic control
a study to evaluate the safety and efficacy of ak120 in subjects with moderate to severe atopic dermatitis

Conditions: Atopic Dermatitis

Summary: this is a multicenter, randomized, open label phase ii clinical study to evaluate the safety and efficacy of ak120 in the treatment of subjects with moderate to severe atopic dermatitis.

this is a multicenter, randomized, open label phase ii clinical study to evaluate the safety and efficacy of ak120 in the treatment of subjects with moderate to severe atopic dermatitis. the total duration of the study (including screening period) planned for each subject is approximately 29 weeks.

Eligibility criteria:
inclusion criteria: 1. male or female subjects aged ≥18≤75 years old. 2. atopic dermatitis (ad) diagnosed at least half a year before screening. 3. subject with easi score ≥16, iga ≥ 3, bsa ≥ 10% at screening and baseline. 4. subjects with a history of an inadequate response or medically inappropriate use of topical drug treatment within 6 months exclusion criteria: 1. received systemic corticosteroids, immunosuppressive/immunomodulatory drugs, phototherapy within the 4 weeks before randomization. 2. received systemic traditional chinese medicine treatment within the 4 weeks before randomization or topical traditional chinese medicine treatment within 1 week before randomization 3. received treatment with other clinical study drugs within 1 month or 5 half-lives before randomization (whichever is longer) 4. received or planned to receive live vaccine treatment within the 3 months before randomization or during the study period. 5. received allergen specific immunotherapy within the 3 months before randomization. 6. have a history of allergies to any component of ak120 and/or severe allergic reactions to monoclonal antibodies.
lsvt big and dual task training in cognitive impaired patients

Conditions: Cognitive Impairment; Balance Changes; Cognition Disorders in Old Age; Functional Mobility

Summary: the goal of this study ifs to determine the comparative effects of lee silverman voice treatment big and dual task training on balance, cognition and functional mobility in older adults with cognitive impairment. perform lsvt big four times in a week for about 4 months. perform dual task training four times in a week for about 4 months. complete assessments at baseline, the 4th, 8th, 12th weeks, and a follow-up at the 16th week. outcome measures include mini bestest, moca, stroop test and time up and go test. statistical analyses will assess within-group and between-group effects based on data distribution.

this study, titled "effects of of lee silverman voice treatment big and dual task training on balance, cognition and functional mobility in older adults with cognitive impairment" aims to assess the combined effectiveness of lee silverman voice treatment and dual task training in older adults with cognitive impairment.

Eligibility criteria:
inclusion criteria: * both male and female patients. * age limit for patients will be above 65. * patients with mild and moderate cognitive impairment patients moca 13-25. * patients with berge balance scale value 41-50. * patients who give consent to participate in study and undergo relevant test. exclusion criteria: * patients with any musculoskeletal disorder in which these exercises are contraindicated. * patients using any walking aids. * patients with hearing impairment. * patients with other neurological conditions with limit the patient participation in planned exercise like stroke, parkinson's. * patients with diagnosed psychiatric disorder or taking medication that affect cognitive function within 24 hours.

Keywords: lsvt big dual task training cognitive impaired patients cognition
effects of biofeedback-based music program using a smart device application on perioperative sleep quality

Conditions: Sleep Quality

Summary: the purpose of this study is to investigate whether the effects of biofeedback-based music programs using a smart device application can improve perioperative sleep quality in patients undergoing breast cancer surgery.

in a biofeedback-based music group, the patient performs an active respiratory intervention session, which induces a slow breathing pattern. if breathing has been slow enough, the automatic mode is activated to provide music based on the patient's own breathing pattern. the investigators will provide biofeedback-based music, which incorporates the patient's respiratory information, while no intervention will be performed in the control group.

Eligibility criteria:
inclusion criteria: * patients undergoing elective breast cancer surgery exclusion criteria: * patients' refusal * day surgery or urgent surgery * bmi ≥35 * neurocognitive impairment, hearing disorder (ex : (dementia, impaired cognitive dysfunction, cerebral infarction, transient cerebral ischemic attack)) * patients with psychiatric diseases, psychological drug intake * pre-existing conditions associated with sleep disorders or drug intake related to sleep
in vitro maturation of human eggs

Conditions: Infertility; Reproductive Techniques, Assisted

Summary: because a large proportion of the embryo's quality is dependent upon the egg, this investigation focuses on treatment of the oocyte during in vitro maturation (ivm). in typical ivf cycles, the egg is recovered when it is mature and ready to be fertilized. however, at this point the oocyte's quality has been set, and cannot be altered. therefore, to have an impact on oocyte quality the use of in ivm is critical. development of a successful ivm protocol for clinical use would not only provide an option for women of advanced maternal age, it would also reduce the cost of ivf due to fewer exogenous gonadotropins used for stimulation, and significantly lessen the risk of ovarian hyper-stimulation. the objective of this research study is to evaluate a newly developed oocyte maturation media system for human clinical use in assisted reproductive technology (art).

the novel device (ivm media system), is designed to support nuclear maturation of immature oocytes recovered after minimal ovarian stimulation with no lh/hcg administration, and improve oocyte competence. this may result in development of a greater number of embryos to the blastocyst stage. fsh is administered starting on cycle day 3 to stimulate follicle growth. when the leading follicle reaches 12-14 mm, egg retrieval will be scheduled. no hcg/lh trigger will be administered. specially designed maturation media is used to collect and culture the immature eggs once recovered from the follicle. once the eggs have matured in vitro, fertilization and embryo culture, vitrification and comprehensive chromosomal screening will be completed as per standard operating procedures.

Eligibility criteria:
inclusion criteria: * infertile women who desire to conceive and come to ccrm for infertility treatment using ivf will be candidates for this study. * women with pcos * patients can be of any race, culture, sexual orientation or ethnicity. exclusion criteria: * minors are excluded from participation in this study. * women with a bmi greater than 40 * women whose health is such that becoming pregnant carries risk significantly greater than healthy women are excluded from this study, unless they use a gestational carrier under the direction of their physician.
demographic, clinical, biological, treatment characteristics and cardiovascular events of patients with heart failure in vietnam: a multicenter prospective observational study

Conditions: Heart Failure; Heart Failure With Reduced Ejection Fraction; Heart Failure With Mid Range Ejection Fraction

Summary: describe the clinical characteristics, paraclinical features, and treatment during hospitalization, as well as at 1, 3, and 12 months post-discharge, of heart failure patients at selected cardiovascular centers in vietnam.

study design: prospective cohort study study subjects: patients discharged with a diagnosis of heart failure with reduced or mildly reduced ejection fraction. inclusion criteria: * patients aged 18 years and older * diagnosed with heart failure at the time of discharge * have an ejection fraction (based on imaging modalities such as echocardiography or cardiac mri) recorded closest to the time of discharge, showing a left ventricular ejection fraction of less than 50% exclusion criteria: * patients and their relatives do not have means of communication with healthcare staff (phone, computer, messaging, etc.) * patients do not reside in vietnam after discharge data collection: * all patients meeting the criteria at the time of discharge during the study period will be continuously included. information regarding demographic data, clinical presentation, biological markers, and in-hospital treatment characteristics will be collected using standardized data definitions from euroheart data standards for heart failure. * periodically after hospital discharge (e.g., 1 month, 3 months, 12 months post-discharge), patients will be contacted by investigators to gather information on their current status, medications, and any cardiovascular events, including rehospitalizations, death, and current medical treatment. * data entry will be performed using the redcap project at the university of medicine and pharmacy, ho chi minh city (https://redcap.umc.edu.vn/)

Eligibility criteria:
inclusion criteria: * patients aged 18 years and older * diagnosed with heart failure at the time of discharge * have an ejection fraction (based on imaging modalities such as echocardiography or cardiac mri) recorded closest to the time of discharge, showing a left ventricular ejection fraction of less than 50% exclusion criteria: * patients and their relatives do not have means of communication with healthcare staff (phone, computer, messaging, etc.) * patients do not reside in vietnam after discharge

Keywords: patient registry heart failure prospective observational study demographic treatment characteristics prognosis mace
a comparison of post-operative analgesia requirements in recreational cannabis users versus cannabis naïve inflammatory bowel disease patients

Conditions: Cannabis Use, Opioid Consumption

Summary: cannabis is a drug that is widely used for recreational purpose. in most patients undergoing surgery, opioids are the most widely used mode of pain relief, during and following surgery. anecdotally it has been observed that cannabis users required unexpectedly high doses of opioids. the purpose of this study is to compare opioid requirements between cannabis users and non- users after the surgery. currently, post-operative opioid doses are determined based on various patient factors such as pre-operative opioid use, patient weight, age and sensitivity to opioids during surgery. patients' requirements may be underestimated and opioid regimens need to be escalated in the first 24 hours in order to alleviate uncontrolled pain in cannabis users. better understanding of the impacts of cannabis use on post-operative opioid requirements would help the acute pain service optimize post-operative pain management for patients who use cannabis pre-operatively.


Eligibility criteria:
inclusion criteria: 1. consent to participate and signed consent form. 2. age: 18-65 years. 3. elective ibd bowel surgery under general anesthesia. 4. pca use.
a study of osseotite certain prevail implants used to support short fixed bridges with immediate occlusal loading.

Conditions: Partial Edentulism; Tooth Disease

Summary: this prospective, multicenter study evaluates the performance of the osseotite prevail implant when to support a short fixed bridge with immediate occlusal loading, providing the patient with the use of a temporary prosthesis until the final prosthesis is made. study (null) hypothesis: this is an observational study in which no concurrent control group will be observed. results of the study will be compared with the performance of other osseotite implants from published osseotite multicenter studies.

this is a prospective, observational study in which all the patients will have implants placed and a provisional prosthesis attached within 24 hours of implant surgery. each restorative case will consist of a posterior short span fixed bridge of four implants or less. the final prosthesis will be placed within five months or implant placement surgery. overall success will be determined on the basis of procedural success, prosthesis success, and implant success.

Eligibility criteria:
inclusion criteria: * patients of either sex and of any race, 18 years of age or older * patients for whom the decision has already been made to use dental implants for treating partial edentulism in the posterior mandible or maxilla using a short span fixed prosthesis of two to four units * patients must be physically able to tolerate conventional surgical and restorative procedures * requirements for implant placement include: at least 1mm bone will be available at the buccal and lingual aspect of the implant and at least 1mm of bone below the apex * patients must agree to return to the clinic for each study follow-up visit * requirements for prosthetic fabrication include: bone width at least 6mm and a bone height of at least 11mm exclusion criteria: * patients with active infection or severe inflammation in the areas intended for implant placement * patients with a \>10 cigarettes / day smoking habit * patients with uncontrolled diabetes or metabolic bone disease * patients with a history of therapeutic radiation to the head * patients in need of bone grafting at the site of the intended study implant; if at the time of surgery some lateral voids need to be filled this is acceptable and does not exclude the patient from the analysis * patients who are known to be pregnant * patients with para-functional habits with evidence of severe bruxing or clenching * placement of implants into sites with less than sixteen weeks of post-extraction healing; for 3-4 unit cases one implant site may have less than sixteen weeks of healing prior to implant placement * type iii or iv bone characteristics of the intended implant sites * inter-arch distance of less than 7mm (planned location of implant seating platform to the apposing occlusal landmark)

Keywords: dental implants osseotite certain prevail multicenter observational clinical study partial edentulism single stage immediate occlusal loading crestal bone level short fixed bridge
meeting the needs of pregnant women with ptsd in prenatal care

Conditions: Posttraumatic Stress Disorder

Summary: the objectives of this research study are to screen 750 pregnant women at risk of trauma-related stress symptoms, and adapt and test an evidence-based intervention for pregnant women with ptsd and sub-threshold ptsd symptoms served by two public payer community health centers.

studies of posttraumatic stress disorder (ptsd) in pregnant women in public payer settings have shown rates 5 or more times that of other populations, and rates as high as 33% of lifetime ptsd sub-threshold symptoms. ptsd during pregnancy has been linked to poor prenatal care and high risk behaviors such as drug and alcohol use and smoking. further, ptsd may pose a barrier to care as obstetric procedures and pregnancy may trigger ptsd symptoms and avoidance of care. ptsd is also associated with pregnancy and birth complications and negative postpartum outcomes including excessive weight gain, preterm birth, low birth weight, risk for parenting problems, and increased barriers to breastfeeding. however, screening, identification, and support for ptsd is lacking. this study will screen 750 pregnant women at risk of trauma-related stress symptoms, and adapt and test an evidence-based intervention for pregnant women with ptsd and sub-threshold ptsd symptoms served by two public payer community health centers.

Eligibility criteria:
inclusion criteria: * mothers who are receiving prenatal care * 18 years or older * in the first 20 weeks of pregnancy * screen positive for posttraumatic stress disorder exclusion criteria: * not pregnant * not currently psychotic * no current suicidal ideation * language other than english, spanish, vietnamese, and portuguese

Keywords: posttraumatic stress disorder prenatal care
measure airway compliance by endobronchial optical coherence tomography

Conditions: Tomography, Optical Coherence; Bronchoscopy; Respiratory Disease; Airway Remodeling

Summary: optical coherence tomography （oct）is a novel, non-invasive, high resolution special optical imaging techniques. in airway, measure airway area and airway wall thickness is the most usage of endobronchial optical coherence tomography (eb-oct）. recently, the new protocol of eb-oct is used to measure airway compliance, we will establish a new methodology of eb-oct for measuring airway compliance, which will provide a new means to study respiratory diseases.


Eligibility criteria:
inclusion criteria: 1. regardless of gender, age 18-70 years old; 2. patients with clinical diagnosis of pulmonary nodules, copd, asthma or restrictive pulmonary diseases; 3. can tolerate bronchoscopy patients; 4. sign the informed consent form. exclusion criteria: 1. suffering from any of the following respiratory diseases: bronchiectasis, etc; 2. have malignant tumors that are not completely remission or cured; 3. the patient's systemic infection is not controlled; 4. recent use of immunosuppressants, recent use of anticoagulants (such as warfarin or aspirin within 2 weeks of drugs that affect blood clotting function); 5. serious other systemic diseases: myocardial infarction, unstable angina, cirrhosis, acute glomerulonephritis, etc.; 6. those who are positive for syphilis, hiv, hbv, and hcv antibodies; 7. patients with coagulation dysfunction diseases, such as hemophilia, giant platelet syndrome, platelet weakness, etc.; 8. severe renal impairment, serum creatinine \> 1.5 times the upper limit of normal value; 9. liver disease or liver function impairment: alt, ast, total bilirubin \> 2 times the upper limit of normal value; 10. those with a history of mental illness or suicide, a history of epilepsy or other central nervous system diseases; 11. 12-lead ecg showing severe arrhythmias (such as ventricular tachycardia, frequent supraventricular tachycardia, atrial fibrillation, atrial flutter, etc.) or conduction abnormalities of the heart of grade ii and above; 12. those who are allergic to catheters and related materials required for experiments; 13. subjects who have received any other clinical studies within 3 months prior to enrollment; 14. those who have poor compliance and difficulty in completing the study; 15. any condition that the clinician believes may increase the risk to the patient or interfere with the clinical study.

Keywords: eb-oct airway compliance airway remodeling