Kornimate/medical-research-clean huggingface dataset:
comparison of naf pet-ct and diffusion mri in the diagnosis of bone metastases (immetaos)

Conditions: Cancer; Bone Metastasis

Summary: prospective, monocentric, comparative, non randomised primary objective : - to compare the diagnostic accuracy of sodium fluoride pet-ct and mri using the conventional block and diffusion sequence in the search for bone metastases secondary objectives : * compare accuracy of mri diffusion and conventional mri * explore the evolution of the results of the different types of imaging over time or under treatment for patients with repeated examinations at 6 months

prospective, monocentric, comparative, non randomised. organization of naf pet-ct and mri on the same day or within a 10 days period. at 6 months : * repeat both exams systematically if one of the initial tests showed a suspicious or doubtful abnormality * final diagnosis by a committee of practitioners using the whole patient's file scheduled project inclusion duration of 36 months (possible adaptation of duration in order to obtain the number of required patients)

Eligibility criteria:
inclusion criteria: * man or woman over 18 years * osteophilic cancer (breast, prostate, lung, kidney, thyroid) proved by pathological material, with a high probability of bone metastases * with an indication to a bone examination: systematic search for metastasis for the staging or due to clinical or laboratory suspicion of bone metastasis * registered in a social security health scheme * written informed consent obtained exclusion criteria: * classical contra-indications for pet ct (suspected pregnancy) or mri (pacemaker, ferromagnetic material); for patients with a possibility of pregnancy (women of childbearing age without contraception and second part of the menstrual cycle, or the slightest suspicion), verification of the absence of pregnancy will be made by the beta hcg dosage before injection of radioactive tracer * uncontrollable claustrophobia with treatment anxiolytic * antitumor treatment started between the two imaging tests * imaging or treatment needed in emergency, if both tests are not performable in time required for the care * inaugural neurological complication * patient unable to undergo biomedical research (under guardianship or deprived of liberty)
a worldwide survey on the understanding of psoriatic disease among patients with psoriasis and psoriatic arthritis

Conditions: Plaque Psoriasis, Psoriatic Arthritis

Summary: the study is a worldwide survey on the understanding of psoriatic disease among patients with psoriasis and psoriatic arthritis.

this is a cross-sectional, quantitative online survey of patients with psoriasis with or without concomitant psoriatic arthritis. following assessment of participant eligibility via a 5-minute online screener, the 25-minute internet-based survey will be conducted without any follow-up.

Eligibility criteria:
inclusion criteria: 1. patients who self-report to have been diagnosed with psoriasis or psoriasis and psoriatic arthritis before or at the time of data collection 2. patients 18 years of age or older at the time of data collection 3. patients who did not participate in surveys regarding psoriasis or psoriatic arthritis in the last 4 weeks 4. body surface area (bsa) of \>5 to \<10, with psoriasis affecting sensitive and/or prominent body parts: face, palms, hands, fingers, genitals, soles of feet or nails or a bsa of 10 and above, when psoriasis was at its worst
brief intervention in primary care for problem drug use and abuse

Conditions: Substance-Related Disorders

Summary: this study will examine the effectiveness of a brief intervention in a primary care setting to reduce drug use or abuse compared to enhanced care as usual.

a substantial body of research has established the efficacy and effectiveness of brief interventions (bi) for excessive or "hazardous" alcohol use in patients seen in medical settings. dissemination projects of brief interventions for alcohol and drugs have recently been implemented on a widespread scale. this rapid progression of brief intervention for drugs other than alcohol has outstripped its evidence base. the aims of the study as outlined in the grant are: 1. to examine whether bi is effective at improving outcomes (self-reported drug use and attendance in drug abuse treatment) in individuals with a wide range of problem drug use over and above enhanced care as usual. the enhanced control condition will consist of routine screening, patient notification, and referral for treatment. 2. to test whether fidelity to the bi model or lower severity of drug use is associated with better outcomes. 3. to estimate the impact of bi on several public health outcomes that are directly related to the hazardous effects of illicit drug use, including the use of acute health care services, involvement in the criminal justice system, employment, hiv risk behavior, and mortality. 4. to estimate the costs of the intervention, potential cost offsets, and its incremental cost-effectiveness versus enhanced usual care from the payer perspective based on health care service use and drug use frequency.

Eligibility criteria:
inclusion criteria: * at least 18 years old * receive medical care at one of the participating primary care clinics at harborview medical center/university of washington medical center * will maintain care at the clinic for one year * have a phone or easy access to phone, voicemail, or email * used recreational drugs in the last 3 months * used prescription medications not as prescribed in the last 3 months exclusion criteria: * participation in any formal substance abuse treatment programs in the last 30 days (excluding 12-step or self-help groups) * terminal illness

Keywords: drug abuse drug addiction drug dependence drug usage drug use disorders substance abuse substance addiction substance dependence substance use disorders
effect of botulinum toxin on hamstring contracture and the occurrence of cyclops syndrome after anterior cruciate ligament reconstruction

Conditions: Hamstring Contractures

Summary: monocentric, prospective, randomised, double-blind study of two parallel groups of 66 patients with post-reconstruction acl hamstring contracture treated with an ultrasound-guided injection at two points on the body of the hamstring * group 1: botulinum toxin: 100 units (0.5ml) in 1 injection * group 2: placebo: 0.5 ml in 1 injection

the study includes three assessments: one month after ligamentoplasty (inclusion visit) and then at m2 and m5. the therapeutic benefit of the study treatments is based on the evolution of the extension defect at m2.

Eligibility criteria:
inclusion criteria: * patient over 18 years of age * patient who has read and signed the consent form for participation in the study * patient operated on for primary acl ligamentoplasty with or without meniscal repair * patient with reducible flatus \>10° at 1 month post ligamentoplasty exclusion criteria: * revision ligamentoplasty * multi-ligament knee * patient under court protection, guardianship or trusteeship * patient not affiliated to the french social security system * patient participating in another therapeutic protocol * pregnant woman or woman of childbearing age without effective contraception * patient unable to understand the informed information and/or to give written informed consent: dementia, psychosis, disturbed consciousness, non-french speaking patient * patient with known hypersensitivity to botulinum toxin * patient with peripheral neuromuscular dysfunction or pronounced atrophy of the semitendinosus muscle * patient treated with anticoagulants, chloroquine (or hydroxychloroquine) * patient treated in the previous seven days with antibiotics or muscle relaxants (such as tubocurarine)
traumatic anal sphincteric injury immediate vs delayed repair

Conditions: Traumatic Anal Sphincteric Injury,Immediate vs Delayed Repair

Summary: comparison between immediate and delayed repair regarding the need for another technique ,pain score or repositioning and need for repair. we aim to evaluate the effects of immediate and delayed repair regarding the morbidity and mortalit * objective 1: to assess the operative time and surgical field of both choices. * objective 2: to estimate post-operative pain using pain score, to measure hospital stay and to assess short -term post-operative complications

many different secondary procedures have been described in an attempt to restore continence. these may be classified into indirect methods, where the divided sphincter is left unrepaired, and direct methods to repair the sphincter itself. indirect techniques include construction of circum anal slings of striated muscle or fascia external sphincter reefing procedures" and the use of striated muscle grafts. direct methods involve identification, mobilization, and suture of the ends of the divided sphincter. thearliest 'attempts employed an end-to-end

Eligibility criteria:
inclusion criteria: 1. both sex 2. - traumatic patients who presented by anal sphincteric injury 3. accept to participate in the study exclusion criteria: 1. patient who arrest immediately when arrived trauma unit 2. obstetric patients who presented by anal sphincteric injury
acute intermittent hypoxia and breathing in neuromuscular disease

Conditions: Amyotrophic Lateral Sclerosis (ALS); Neuromuscular Diseases

Summary: this project seeks to investigate the effects of a single acute intermittent hypoxia (aih) session on respiratory and non-respiratory motor function and emg (electromyography) activity on patients with als (amyotrophic lateral sclerosis) and healthy controls.

most als patients survive less than 5 years after diagnosis, and the main cause of death is respiratory failure. the investigators are interested in the therapeutic potential of acute intermittent hypoxia (aih) for individuals with neuromuscular diseases, such as als. more than two decades of research indicates aih elicits meaningful respiratory and non-respiratory motor recovery. acute intermittent hypoxia (aih) consists of alternating periods of breathing mildly hypoxic (lowered oxygen concentration) and normoxic (normal oxygen concentration) air. the investigators propose to study mechanisms of respiratory plasticity associated with a single presentation of mild aih. the fundamental hypothesis guiding this proposal is that even a single aih trial improves respiratory (and non-respiratory) motor function in als patients procedure. participants will then be asked to breathe air with reduced oxygen for short periods of time, for a duration of 45 minutes. the activity of your muscles and your heart function will be monitored throughout the procedure.

Eligibility criteria:
inclusion criteria: * a healthy adult * clinical diagnosis of als * baseline fvc \>60% predicted for age, sex and height. exclusion criteria: * pregnant * diagnosed cardiovascular disease * a bmi \>35 kg/m2 * currently take selective serotonin reuptake inhibitors (ssri) * history of seizures * history of hospitalization for sepsis * respiratory infection or took antibiotic medications within the past 4 weeks * use external respiratory support during any waking hours * participate in a pharmaceutical trial to treat als * have any other medical condition the pi or medical director identify would make it unsuitable to participate.

Keywords: acute intermittent hypoxia (aih) respiratory motor function hypoxia normoxia emg (electromyography)
a trial to test an acceptance-based therapy program among adolescent girls with overweight/obesity

Conditions: Weight Loss; Obesity; Overweight

Summary: the purpose of this study is to investigate the effects of an acceptance-based therapy weight loss intervention compared with enhanced care for adolescents.

participants will complete baseline assessments and adolescents will be randomized to either an abt weight loss intervention or enhanced care. the intervention will include 15 sessions over 6 months. enhanced care will include 15 healthy lifestyle handouts over 6 months. post-treatment assessments will occur.

Eligibility criteria:
inclusion criteria: * adolescent between ages 14-19 with overweight or obesity at or above the 85th percentile for sex and age as determined by cdc growth charts exclusion criteria: * known pregnancy or plans to become pregnant in the next 2 years * plans to move out of the area in the next year * autism, any intellectual disability (e.g., down syndrome) * any condition prohibiting physical activity * a diagnosis of cardiovascular disease or diabetes * have active cancer or cancer requiring treatment in the past 2 years * have active or chronic infections (e.g., hiv or tb) * have active kidney disease or lung disease * an eating disorder or substance abuse disorder * having recently begun a course of or changed the dosage of any medications known to affect appetite or body composition * weight loss greater than or equal to 5% in the previous 6 months * if they do not follow the study plan

Keywords: acceptance-based therapy adolescents weight weight loss obesity overweight
ultrasound-guided radiofrequency ablation of the genicular nerve versus physical therapy for chronic knee osteoarthritis

Conditions: Chronic Knee Osteoarthritis

Summary: the aim of this study is to compare the effects of conventional physiotherapy methods with ultrasound-guided radiofrequency ablation of the genicular nerve on pain and functional status in patients with stage 2-3 chronic knee osteoarthritis.

patients diagnosed with chronic knee osteoarthritis according to the american college of rheumatology criteria, and with radiological osteoarthritis at kellgren-lawrence grades 2 and 3, within the age range of 45-70, and meeting the study criteria will be included in the study. after providing information about the procedures to be performed and potential risks to the patients, if they give their written informed consent, treatment methods will be applied to the patients. eligible patients will be divided into two groups. in one group, radiofrequency ablation of the genicular nerve under ultrasound guidance will be performed, while the other group will receive physical therapy.

Eligibility criteria:
inclusion criteria: * vas ≥ 5 * to be aged between 45 and 70 years old * patients diagnosed with chronic knee osteoarthritis using the american college of rheumatology criteria and having radiological osteoarthritis of kellgren-lawrence grade 2 and 3 * cognitive functions being intact * being willing to participate in the study and signing the consent forms exclusion criteria: * having received physical therapy for chronic knee osteoarthritis in the last 6 months * having received glucocorticoid or hyaluronic acid injections in the last 6 months * having taken oral glucosamine * undergoing knee surgery * having current neurological or mental disorders * history of pacemaker usage * presence of local infections or sepsis * progressive neurological deficit * presence of oncological diseases * hemorrhagic diathesis or anticoagulation * uncontrolled diabetes or other serious internal comorbidities * allergy to medications or materials used * pregnancy * lack of cooperation * not willing to participate in the study.

Keywords: knee osteoarthritis genicular nerve block ultrasound radiofrequency chronic pain
relaxation before debriefing and memorization in high fidelity simulation in healthcare

Conditions: Anxiety

Summary: resident in advanced medical training participated to high fidelity simulation education program in lyon. alternatively 1 or 2 resident act during a scenario while the others observe in a teletransmission closeby room. debriefing follows the critical scenario in witch resident are involved. the investigators are testing the effects of five minute of conversational relaxation before the debriefing on the anxiety level and memorization of key points each scénario on participant and observer.

resident in advanced medical training participated to high fidelity simulation education program in lyon. this is part of a curriculum and each year they go throw a specific simulation session in groups of 3 to 8 residents with same specific thematic education goals. 3 to 4 differents scénario are run every simulation session during 4 to 5 hours, every day 2 similar session are run with 2 different groups of same level residents. alternatively 1 or 2 resident act during a scenario while the others observe in a teletransmission room. debriefing follows the critical scenario in witch resident are involved. the investigators are testing the effects of five minute of conversational relaxation before the debriefing on the anxiety level and memorization of key points each scénario on participant and observer. relaxation is done reading a text outloud by an instructor before the debriefing. each scenario is run in the morning and the afternoon and alternatively have relaxation or not. evaluation is done on participant of the scenario and resident observer of the situation. the investigators ask participant for demographic data, anxiety scale test, multiple anxiety visual analogic scale. at the end of every scenario 5 clinical key point of teh scenario are exposed. at 3 month the investigators call back every participant to ask them to remember these 5 points for the scenario they were involved in and one of the other they observed.

Eligibility criteria:
inclusion criteria: * every resident going to a scheduled simulation session part of the normal education program of the residency. exclusion criteria: * no consent, or consent deleted

Keywords: simulation anxiety debriefing memorization
validation of a french-version of the leeds food preference questionnaire in normal weight and patients with obesity

Conditions: Normal Weight Adults; Adults With Obesity

Summary: while food reward is an important component of the appetite control to consider, there is actually no tool that has been developed in french to perform its evaluation. the leeds food preference questionnaire (lfpq) is a validated and recognized tool to assess food reward, being however developed for british populations. the aim of this work is to validate a french version of the lfpq among lean and obese adults.

50 lean and 50 patients with obesity between 20 and 55 years old (50% women and 50% men), will be recruited. after an evaluation of their body composition by impedance meter, and of their dietary status by questionnaires (tfeq/debq), they will be asked to perform twice the same experimental sessions. they will be asked during this session to arrive at 08:00 am after a 12-hour fast and will receive a calibrated breakfast. before and after a lunch calibrated meal, they will be asked to perform the french version of the computerized questionnaire lfpq. appetite feelings will be assessed at regular intervals.

Eligibility criteria:
inclusion criteria: * bmi between 30 and 38 kg.m² for the obese patients and 20 and 25 for the lean ones. * registered to the national social security system * signed consent exclusion criteria: * eating disorders * metabolic disease such as hypertension and type 2 diabetes

Keywords: appetite food reward methodological approach
spartan covid-19 system: evaluation of clinical sample collection

Conditions: Covid19

Summary: this study will evaluate the efficacy of various sample collection methods for use with the spartan covid-19 system. it will compare the results from the spartan covid-19 system with results that are obtained using a predicate lab-based covid-19 test that uses a nasopharyngeal swab sample. the goal is to determine which sample collection methods are most effective in capturing sars-cov-2 virus.

once the subject is recruited,two nasopharyngeal swabs using the standard method will be taken from the patient. additionally, two nasal swab samples will be taken using the spartan covid-19 swabs with an adjusted tip. all samples will be analyzed using the spartan covid-19 system. the lab-based predicate test will be taken at the same time, with results reported back to spartan to be compared with results obtained from the spartan covid-19 system.

Eligibility criteria:
inclusion criteria: * must have tested positive for covid-19 via the existing nucleic acid testing method. exclusion criteria: -
behavioral lifestyle intervention study (blis) in patients with type 2 diabetes in uae: a randomized controlled trial in real life setting

Conditions: Type 2 Diabetes

Summary: the primary purpose of this study is to develop a behavioral lifestyle intervention and evaluate its effectiveness in improving the glycemic control in patients with type 2 diabetes in real life setting. this is because ambiguity still exists on the effectiveness of behavioral lifestyle interventions in routine clinical practice despite of the efficacy of large randomized controlled trials, suggesting the need for more research in this area.


Eligibility criteria:
inclusion criteria: females or males. type 2 diabetes. bmi (kg/ m²) ≥ 25. age 18-60 years old. hba1c \> 7%. exclusion criteria: major physical activity disability that restricts participation in moderate physical activity. serious heart condition like heart failure, heart attack, stroke within the last 3 months. participating in a weight management or lifestyle program. presence of proliferative retinopathy or kidney failure.

Keywords: cognitive behavior therapy lifestyle modification hba1c carbohydrates
retrospective evaluation of minimally-invasive surgical strategies in ovarian neoplasms (remission study)

Conditions: Early-stage Epithelial Ovarian Cancer

Summary: this observational study aims to evaluate the outcomes of patients with early-stage epithelial ovarian cancer who are treated with minimally invasive surgery (such as laparoscopic or robotic surgery). specifically, the study will look at: 1. post-surgery complications * what is the rate of complications within 30 days after surgery? * how often do patients require readmission to the hospital, re-operation, or conversion to open surgery? 2. cancer outcomes * what is the rate of cancer upstaging (when the cancer spreads to a more advanced stage during surgery for example because of an intra-operative ovarian cyst rupture)? * what are the overall survival and disease-free survival rates for patients treated with minimally invasive surgery? researchers will compare two groups of patients: group 1: patients with early-stage ovarian cancer treated with minimally invasive surgery. group 2: patients with early-stage ovarian cancer treated with open surgery. the goal is to see if there are any differences in post-surgery complications, recovery, and cancer outcomes between the two groups. fertility-sparing treatment: the study will also compare patients who are undergoing fertility-sparing treatments for early-stage ovarian cancer. two subgroups will be looked at: * patients receiving fertility-sparing surgery through a minimally invasive procedure. * patients receiving fertility-sparing surgery through an open surgery. the same outcomes (complications, survival, etc.) will be assessed and compared between these two groups as well.


Eligibility criteria:
inclusion criteria: 1. patients with apparent early-stage epithelial ovarian cancer at preoperative evaluation 2. patients who underwent surgery between january 2014 and december 2023 3. patients who underwent open or minimally invasive surgical staging (laparoscopic or robotic-assisted approach) or restaging procedure 4. patients with final pathology report of epithelial ovarian cancer exclusion criteria: 1. patients who have not performed a complete surgical staging 2. patients who underwent neoadjuvant chemotherapy 3. patients with invasive synchronous tumor 4. patients with no informed consent 5. patients with asa class score of 4 or 5

Keywords: early-stage epithelial ovarian cancer minimally invasive surgery