Kornimate/medical-research-clean huggingface dataset:
hematopoietic cell transplantation with post-transplantation cyclophosphamide in mds

Conditions: Myelodysplastic Syndromes

Summary: this study is conducted to evaluate the feasibility and efficacy of post-transplantation cyclophosphamide with myeloablative or reduced-intensity conditioning regimen for allogeneic hematopoietic cell transplantation (hct) in patients with myelodysplastic syndrome (mds).

* conditioning regimen a) busulfan 3.2 mg/kg/day i.v. daily for 4 days (days -7 to -4) in patients aged \< 55 years for 2 days (days -7 and -6) in patients aged ≥ 55 years b) fludarabine 30 mg/m2/day i.v. daily on days -7 to -2 (for 6 days) * harvest and infusion of donor hematopoietic cells harvested peripheral blood mononuclear cells of donors via leukapheresis will be infused to recipients on day 0. additional infusion on day 1 can be made based on the judgement of attending physician. * gvhd prophylaxis a) cyclophosphamide 50 mg/kg/day i.v. daily on days 3 and 4 (for 2 days) b) cyclosporine: 1.5 mg/kg i.v. every 12 h hours beginning on day 5 and changed to oral dosing when oral intake is possible. if there is no evidence of gvhd, the dosage will be tapered beginning on day 90 and discontinued on day 180. c) mmf: 15 mg/kg p.o. 3 times daily with a maximum daily dose of 3.0 g beginning on day 5 if there is no active gvhd, cyclosporine and mmf will be discontinued without taper at day 180 and 35, respectively.

Eligibility criteria:
inclusion criteria: * mds defined by who classification, chronic myelomonocytic leukemia (cmml), or acute myeloid leukemia (aml) evolving from mds a. ipss \> 1.0 or bone marrow blast ≥ 5% at any time points before hct or b. aml progressed from mds or c. cmml * patients receiving first hct * patients with appropriate hematopoietic cell donors a. hla-matched sibling donor b. unrelated donor c. hla-mismatched familial donor * 15 years old or older * adequate performance status (karnofsky score of 70 or more) * adequate hepatic and renal function (ast, alt, and bilirubin \< 3.0 x upper normal limit, and creatinine \< 2.0 mg/dl). * adequate cardiac function (left ventricular ejection fraction over 40% on heart scan or echocardiogram * signed and dated informed consent must be obtained from both recipient and donor. exclusion criteria: * presence of significant active infection * presence of uncontrolled bleeding * any coexisting major illness or organ failure * patients with psychiatric disorder or mental deficiency severe as to make compliance with the treatment unlike, and making informed consent impossible * nursing women, pregnant women, women of childbearing potential who do not want adequate contraception * patients with a diagnosis of prior malignancy unless disease-free for at least 5 years following therapy with curative intent (except curatively treated nonmelanoma skin cancer, in situ carcinoma, or cervical intraepithelial neoplasia)

Keywords: mds aml progressed from mds cmml
effects of an educational program on depression literacy and stigma among secondary school students in jazan city

Conditions: Depression Literacy; Depression Stigma

Summary: depression is a serious mental health disease. it is generally characterized by sadness, loss of interest in activities, and decreased energy. globally, it is estimated that almost 350 million people suffer from depression. in saudi arabia, literature suggested that prevalence of depression among boy's secondary school students in abha city was 38.2%. another study found that the prevalence of depression was 22.4 % as moderate, 7.3 % as severe and 3.7% as very severe, with a clear predominance prevalence of depression in girls as in boys (1.5 times). it is important to assess depression literacy including knowledge and beliefs about mental disorders among adolescent. a high level of mental health literacy on depression leads to a better understanding and outcomes of depressive disorders. schools are a typical venue in which to embed mental health literacy because the school students are more familiar with educational activities. studies concluded that educational intervention about depression literacy and destigmatization improves knowledge and may decrease stigma. further research, intervention and activism are needed in the field of mental health in arab countries to improve awareness of mental health problems. objectives: this study is aimed to measure the effect of educational intervention program about depression among secondary schools in jazan city on depression literacy and stigma during the academic year 2015-2016. the intervention: the intervention will held at each selected intervention school separately. the program will be over 2 weeks intervention as the following: * educational strategies: 2 lecture about depression 30 minutes supported by group discussion, brochures and display of posters with mental-health slogans on depression in the schools. * contact strategies: the investigators will show a video of a young male who had been diagnosed (i.e., not an actor) with depression. benefits: \* the intervention group will join educational intervention program they expected to benefit from the program through increase their depression literacy and improve depression stigma, and control group will not join any form of intervention. risk: there is no expected risk for participating in the study. consent: three informed consents forms will be signed from students, guardians and school manager.


Eligibility criteria:
inclusion criteria: * students needed to be enrolled in one of the selected schools during the academic year 2015-2016. * must be in the age group 10-19 years. * must agree to participate in the study (consent was obtained from the students,and proxy consent was obtained from guardians). exclusion criteria there were no exclusion criteria for participation in this study.
effectiveness of kneemd on flexion contracture in total knee arthroplasty patients

Conditions: Flexion Contracture

Summary: the purpose of this study is to evaluate the effect of the kneemd subject-controlled knee rehabilitation device on the incidence of postoperative flexion contracture.

postoperative flexion contracture (fc), defined as \>10°, is the most common disabling early complication of primary total knee replacement (tkr) surgery, affecting up to 6% of all subjects. a knee flexion of 65° is required to walk, 70° is needed to lift an object from the floor, 85° to climb stairs, 95° for optimal sitting and standing, and 105° to tie shoelaces. with growing subject and physician expectations for function and range of motion (rom) after surgery, fc complications have become an early measure of success in tkr surgery. the purpose of this study is to evaluate the effect of the kneemd subject-controlled knee rehabilitation device on the incidence of postoperative fc. the primary endpoints are the preoperative change in active range of motion (arom) and the incidence of postoperative fc at 2 weeks. secondary endpoints include the change in arom in subjects with postoperative fc.

Eligibility criteria:
inclusion criteria: 1. measurable knee flexion contracture, with deficit limiting active range of motion (arom) and passive range of motion (prom) by at least - 10° 2. 18 years of age and older 3. able to understand informed consent and willingness to conform to trial responsibilities exclusion criteria: 1. previous surgical treatment of knee, including tibial osteotomy 2. botulinum toxin treatment within the last four months 3. mechanical joint impingement 4. neuromuscular pathologies such as epilepsy 5. treatment with quinolone, antibiotic medication 6. pregnant or nursing 7. fractures 8. osteomyelitis or any orthopedic infection 9. extensor mechanism dysfunction 10. knee joint neuropathy 11. previous stroke or brain injury
pilot study: parkinson's conventional physiotherapy vs home-based telerehabilitation

Conditions: Parkinson Disease

Summary: the parkinson telerehabilitation-net pilot study (parkinson telerehab-net) is designed to observe and monitor pd patients in their initial phase (which includes the period from the onset of motor symptoms until the onset of motor fluctuations) and to assess the feasibility of an integrated multidimensional approach in treating and managing pd patients in a local clinical setting (asl cn1). chiefly, through this pilot study, feasibility and acceptability of the general experimental plan, as well as the potential for positive effects of physiotherapy in early pd patients will be assessed. so, this pilot study primarily aims at: 1. validating the feasibility of the study protocol, assessing participants' inclusion and exclusion criteria, testing instruments/procedures used for home rehabilitation (both for the telerehabilitation exercise group - tre arm and for the home self-exercise group - hse arm), testing the suitability of the method for data collection; 2. obtaining the required preliminary data for the calculation of a sample size for the primary outcome, in both arms; 3. evaluating appropriateness of the consent form, recruitment potentials, time needed to receive written consent, and the required number of researchers/medical specialists/physiotherapists needed to cover the whole study path; 4. assessing patients' acceptability of the intervention, through the evaluation of the adherence to rehabilitation process (in both arms), the completeness of proposed measurements, and compliance at follow-up. secondary objectives are the monitoring of patients' perceived quality of life, and of motor performance and non-motor symptoms through specific rating scales, after completing the whole rehabilitation path (described below) compared to baseline level, and maintenance of results over time.


Eligibility criteria:
inclusion criteria: general: * adults, aged 18 or older; * medical diagnosis of idiopathic pd according the most recent movement disorder society diagnostic criteria; * disease stage ≤ 2 on the hoehn\&yahr scale; * montreal cognitive assessment score \>25; * ability to read, understand and provide a written informed consent, in accordance with good clinical practice and local regulations; * motivation and possibility to show up for planned controls and to comply with the requested study procedures. specific for tre arm: * wireless internet access at home; * adequate room to place telerehabilitation device (about 2 meters in front of device monitor). exclusion criteria: * \<18 years of age; * any atypical, iatrogenic, or secondary parkinsonism; * disease stage \> 2 on the hoehn\&yahr scale; * any severe orthopaedic, vascular, respiratory, or cardiac problems or any other medical condition that, in the principal investigator's opinion, could limit participation in moderate exercise or the study protocol.

Keywords: parkinson disease telerehabilitation physical activity physical therapy modalities
fentanyl test and a short osas screening scale for severe obstructive sleep apnea

Conditions: Obstructive Sleep Apnea

Summary: the aim of this study was to estimate and compare the value of the preoperative fentanyl test and the short osas screening scale to diagnose severe obstructive sleep apnea；and to observe the required amount of hydromorphone and the adverse respiratory events after adenotonsillectomy.

the results of polysomnography were obtained before adenotonsillectomy, and the short osas screening scale was completed by the subjects' parents in preoperative interview. all children were induced by sevoflurane inhalation. after eyelash reflex disappeared and pharyngeal airway insertion, giving 1 mcg/kg fentanyl when the end-tidal concentrations of sevoflurane were maintained at 3.0 and the spontaneous respiratory frequency was stable, observing the changes of respiratory rate. severe osas was diagnosed as respiratory rate decreased by more than 50%. anesthesia was maintained with desflurane and 60% nitrous oxide in oxygen. the children were transferred to the pacu after extubation. the postoperative pain and agitation were assessed according to the children's hospital of eastern ontario pain scale (cheops) and the pediatric anesthesia emergency delirium (paed) score, and all children were given hydromorphone for pain relief according to our protocol.

Eligibility criteria:
inclusion criteria: 1. the american society of anesthesiologists (asa) class ⅰ \~ ⅱ 2. age greater than or equal to 3 years 3. children were diagnosed by polysomnography and plan to adenotonsillectomy. exclusion criteria: 1. craniofacial malformations 2. mental retardation 3. bmi \> 30 kg/m2 4. combined with other neuromuscular diseases 5. a recent history of opioid use

Keywords: fentanyl osas screening scale adenotonsillectomy diagnose
snap wound care system versus traditional npwt device for treatment of chronic wounds

Conditions: Ulcers; Wounds

Summary: the purpose of this study is to evaluate a novel negative pressure wound therapy (npwt) device called the snap device compared to a traditional npwt device for the treatment of lower extremity diabetic and venous ulcer wounds.

this is a prospective, randomized, two-arm, non-inferiority, multi-center study comparing negative pressure therapy wound healing outcomes between the snap wound care system and traditional npwt systems.

Eligibility criteria:
inclusion criteria: * subject has venous ulcer or diabetic ulcer with a surface area \< 100 sq. cm and \< 10 cm in widest diameter on lower extremity, but larger than 1 sq. cm * subject has wound present for \>30 days despite appropriate wound care * subject has adequate blood perfusion (defined as either transcutaneous oxygen measurements of the dorsum of the foot \>30 mmhg or 0.7 \< abi \<1.2) * subject has wound in location amendable to creation of airtight seal around wound using npwt dressings * subject is able to understand and provide written consent * subject able to understand and provide written consent * male or non-pregnant female willing to have urine pregnancy test exclusion criteria: * subject has active infection (redness, swelling, pain, purulent exudate) * subject has untreated osteomyelitis * subject has allergy to wound care products used in the study * subject has malignancy, burn, collagen vascular disease, sickle cell, vasculopathy, or pyoderma gangrenosum origin of wound * subject has active charcot arthropathy of the foot * subject has study wound location on toes or plantar surface of foot * subject has uncontrolled hyperglycemia (hba1c \>12%) * subject has end stage renal disease requiring dialysis * subject is undergoing active chemotherapy treatment that inhibits wound healing * subject has had previous treatment with npwt device, growth factors, hyperbaric oxygen, or bioengineered tissue product within 30 days of enrollment * subject has a \>30% wound surface area reduction in size at 1 week after screening visit * subject has any other condition that, in the opinion of the investigator, makes the subject inappropriate to take part in this study * subject is unwilling or unable to comply with protocol requirements * subject is pregnant

Keywords: ulcer venous diabetic wounds and injuries
a study of abilify® tablet(aripiprazole) as an adjunctive treatment in the bipolar depression

Conditions: Depression, Bipolar

Summary: this is an 8-week, multicenter, randomized, double blind, placebo controlled study to evaluate the efficacy and safety of aripiprazole as an adjunctive treatment with mood stabilizer for the treatment of patients (outpatients or inpatients) with type i or ii bipolar disorder accompanied by major depressive episode, without any psychotropic features. this study involves patients who are considered by the investigator not to have a proper improvement, despite receiving a mood stabilizer (lithium or valproic acid) for a sufficient (≥ 28 days) period of time during the current depressive episode.


Eligibility criteria:
inclusion criteria: * patients aged ≥ 19 and \< 70 years at the time of informed consent * patients who are able to understand information required for providing a consent * patients who have received a mood stabilizer (lithium or valproic acid) * patients with bipolar i or ii disorder accompanied by major depressive episode * montgomery-åsberg depression rating scale (madrs) total score ≥ 20 at both the screening and baseline visits exclusion criteria: * patients diagnosed with bipolar i or ii disorder with mania, mixed or psychotropic features * patients considered to have a high risk of suicide during the study period by the investigator based on current psychotic symptom and the patient's past medical history
analysis of the capnography curve can allow the discrimination of obstructive patients - modeling the capnography curve

Conditions: Respiratory Pathology; Obstructive Syndrome

Summary: obstructive respiratory diseases such as asthma or copd are a common reason for emergency room visits. currently, nasal gill capnography and oxygen saturation measurement (spo2) are the only two non-invasive means of continuously monitoring a respiratory pathology. to date, respiratory functional explorations (cfe) and more particularly spirometry, are considered as the reference examinations for the diagnosis or monitoring of asthma or copd. however, physical and physical constraints make their use almost impossible in the context of the emergency with patients presenting to emergencies in respiratory distress, often require oxygen therapy or even non-invasive ventilation. only pulmonary auscultation can make the diagnosis of acute decompensation of obstructive pathology. this technique is qualitative and imprecise, sometimes leading to a diagnostic uncertainty resulting in delay in taking charge and inappropriate therapy. studies have shown a change in the capnography curve in obstructive airway disorder and a strong correlation between some capnography parameters and spirometry parameters such as the tiffeneau ratio (fev1 / fvc), suggesting capnography as a simple and effective technique for the diagnosis of obstructive syndrome of patients in emergencies.


Eligibility criteria:
inclusion criteria: * major patient male or female * patient with respiratory disease with and without obstructive syndrome or patient without respiratory pathology * patient requiring spirometry breathing functional exploration * subject affiliated to a social health insurance scheme * subject able to understand the objectives and the risks related to the research and to give its non opposition exclusion criteria: * pregnant and lactating woman * patient not affiliated to a social protection scheme * subject in exclusion period (determined by previous or current study), * impossibility of giving the subject information enlightened (subject in emergency situation, difficulties of understanding the subject, ...) * subject under the protection of justice subject under guardianship or curatorship

Keywords: capnography
cerebral responses to insulin induced hypoglycemia

Conditions: Type 1 Diabetes; Healthy; Hypoglycemia Unawareness

Summary: this research study is designed to investigate the effect of hypoglycemia (low blood sugar) on blood flow to and biochemistry in the brain.

the purpose of this study is to better understand the effect of low blood sugar (hypoglycemia) on blood flow and biochemistry in the brain. hypoglycemia is a serious complication of diabetes treatments. it has been previously observed that hypoglycemia causes an increase in blood flow to certain parts of the brain, but it has been difficult to determine which parts of the brain specifically have an increase in blood flow. with new technology, it is now possible to determine the rate of blood flow in very small parts of the brain. the investigator expects that people with type 1 diabetes and hypoglycemia unawareness, poorly controlled diabetes, and normal subjects will have different rates of blood flow to different parts of the brain in response to hypoglycemia. having a greater understanding of how the brain adapts to hypoglycemia may help us develop better ways to treat diabetes more safely.

Eligibility criteria:
inclusion criteria: * well controlled type 1 diabetes (hemoglobin a1c \<7.5%) * healthy controls exclusion criteria: * history of stroke, seizures, neurosurgical procedures, or arrhythmias * use of drugs that can alter gaba (gamma-aminobutyric acid) metabolism (such as benzodiazepines). * subjects must also meet requirements for a study in the magnet, which includes weight less than 300 lbs and the absence of metallic substances in their body.

Keywords: type 1 diabetes hypoglycemia unawareness healthy control
prescription of triptans in the grand est region, france

Conditions: Migraine

Summary: the high frequency of migraine contrasts with the disparity of its management. the framig 3 study, carried out in france on the basis of the definition criteria of migraine of the ihs 2004 classification, identified, on the basis of a questionnaire of a representative sample of the general population of 10532 people, 11.2% of the people meeting the criteria of defined migraine and 10.1% of the criteria of probable migraine. only 40.2% knew they had migraine. 50% used self-medication. although available since the late 1990s as an effective and specific treatment for migraine attacks, 7.5% of migraineurs in the framig 3 study used a triptan. in 2003-4, 1.5% of the 1,793,000 inhabitants of alsace had received at least one prescription for triptans over a one-year period. 1.9% of them were considered overconsumers (greater than or equal to 144 doses/year). more than 10 years later, another population-based study, using data from the french national health agency, identified 1.8% of insured persons receiving a triptan. several migraine prophylactic treatments have been shown to be effective in patients with frequent or severe migraine attacks, or who do not respond to crisis treatment, or who claim poor quality of life due to migraine, but only 50% of candidates for such prophylactic treatment were receiving it. only 1.5% of migraine patients in the framig 3 study were taking prophylaxis. quality of life was impaired in 57% of migraineurs in the usa and in 28% of french migraineurs. in ali's study (ali 2017), 6.9% of migraineurs had used a neurologist. a brazilian study shows that the average delay of patients accessing a tertiary center was 17 years. as promising new prophylactic treatments become available, we wanted to study a population of migraineurs identified on the basis of a triptan prescription, in order to try to better identify the characteristics of this population, particularly in terms of analgesic consumption and use of specialized care. the objective of this study was to describe the quantity of triptans dispensed to residents of the grand est region aged 12 years and older, between june 1, 2018, and june 1, 2019, based on health insurance data. the secondary objectives were to compare the characteristics of insured persons who had at least one triptan dispensing with those of other insured persons, and to compare the characteristics of insured persons by quantity of triptans dispensed.


Eligibility criteria:
inclusion criteria: * beneficiary of the general health insurance scheme between june 2018 and june 2019 * at least 12 years old * resident in the grand est region exclusion criteria: * none