Kornimate/medical-research-clean huggingface dataset:
effects on the personalized rehabilitation service in patients with cancer

Conditions: Breast Cancer; Breast Neoplasms; Breast Cancer Female; Lymphedema

Summary: in order to study the effectiveness of personalized healthcare service program for breast cancer rehabilitation, investigators designed this study using mobile phone and clinical intervention(feedback coaching).


Eligibility criteria:
inclusion criteria: * breast cancer patient (age over 18), cancer stage under 3, android os smartphone user exclusion criteria: * cancer stage over 4, patients diagnosed with multiple cancer, patient who cannot participate rehabilitation exercise program
effect of scapular stabilization exercises on scapular muscles strength and kyphosis index in smartphone users

Conditions: Muscle Weakness; Smartphone Addiction

Summary: this study will be conducted to investigate the effect of scapular stabilization exercises on scapular muscles strength (serratus anterior, lower fibers of trapezius, rhomboid major and minor), pain intensity level and kyphosis index in different duration of time using daily of smartphone in smartphone users.

modern people use a smartphone along the day, including occupational and leisure activities. repeated and prolonged use of smartphones affecting muscular activity and strength around the shoulders and upper back especially serratus anterior during maintaining an un ideal posture which may result in the development of postural changes as excessive thoracic kyphosis which in turn will result in inadequate muscles contractions, weakening of postural muscles and fatigue. scapular muscles strength should be balanced or integrated (muscle balance) and worked in synchronized motion, so, alteration in scapulothoracic motion in resting position or dynamic motion of scapula described as scapulothoracic dysfunction. muscle imbalances occurs and lower trapezius, serratus anterior and rhomboids muscles are the most common muscles prone to weakness due to exposure to sustained awkward posture or adaptive postures and restriction to specific activity. continuous use of smartphone for more than 4 hours daily increases shoulder and parascapular pain, fatigue, decrease strength of scapular muscles (lower fibers of trapezius for scapular adduction and depression and rhomboids for scapular adduction and downward rotation) in right dominant side due to prolonged hyperactivity, then weakness.the excessive use of smartphones correlates with increases incidence of vertebral static disorders, especially kyphosis. scapular stabilization exercises were effective in the early rehabilitation and the balance of both sides of the trapezius with the movement and couple motion of the scapula. it is also effective in increasing muscle activation in the serratus anterior and lower trapezius.

Eligibility criteria:
inclusion critria * normal subjects from both genders. * subjects had to be right hand dominant. * age ranged from 17 to 45 years old. * all subjects had at least 6 months experience in using touch-screen smartphones. * the mean of smartphone size included in the study will be 5 inches (mohamed et al., 2020). exclusion criteria: * any pain or limitation (dysfunction) at neck and shoulder. * any congenital abnormalities in either the cervical or the lumbar spine. * previous history of severe surgical procedures. * any history of upper extremity injury within the past year. * visual problems, dizziness and vertigo. * any deformity in the upper extremities or spine. * neurological or systemic disorders. * if they had taken any sedative drug or alcohol within the past 48 hours.
using mc1r genotype to impact melanoma risk behavior

Conditions: Melanoma (Skin); Squamous Cell Carcinoma; Squamous Cell Cancer; Skin Cancer; Basal Cell Carcinoma; Basal Cell Cancer

Summary: the purpose of this study is to examine how different messages about risk of melanoma can impact the way people protect themselves against developing these diseases.


Eligibility criteria:
inclusion criteria: criteria for: non-hispanic white population * investigators will recruit participants from the family medicine and general internal medicine clinics of the morsani center at the university of south florida. * white, non-hispanic patients who self-report a low phenotypic risk profile for development of melanoma and are able to read and speak english fluently. * 18 years of age or older * capable of giving informed consent * potential participants will be screened for eligibility based on responses to questions about skin phenotypes, early detection behaviors and past history of melanoma. * after signing informed consent, a biologic sample (saliva) will be collected for the purpose of dna extraction determination of mc1r genotypes. all participants who carry high risk mc1r genotypes and a proportion of those who carry low risk or no mc1r variants will be randomized to the control or intervention arm. criteria for: hispanic population * investigators will recruit participants living in tampa bay and puerto rico as part of the u54 ponce health sciences university-moffitt cancer center (phsu-mcc) partnership. in tampa bay, participants will be recruited from the family medicine and general internal medicine clinics of the morsani center at the university of south florida, and from the suncoast community health centers. * patients who self-report as hispanics and are able to read and speak either spanish or english fluently. * 18 years of age or older * capable of giving informed consent * potential participants will be screened for eligibility based on responses to early detection behaviors and past history of melanoma. * after signing informed consent, a biologic sample (saliva) will be collected for the purpose of dna extraction determination of mc1r genotypes. all participants who carry high risk mc1r genotypes and a proportion of those who carry low risk or no mc1r variants will be randomized to the control or intervention arm. exclusion criteria: criteria for: non-hispanic white population * have had a skin examination within the past year. * do not meet race/ethnicity criteria for their group * white, non-hispanic group - participants reporting sun-sensitive phenotypes * a personal history of melanoma criteria for: hispanic population * have had a skin examination within the past year. * do not meet ethnicity criteria for their group * white, non-hispanic group - participants reporting sun-sensitive phenotypes * participants with a personal history of melanoma and/or more personal history of more than on squamous cell cancer (scc) and/or basal cell cancer (bcc)

Keywords: skin cancer prevention educational materials skin cancer risk questionnaire mc1r genotype
roles of micrornas in the development of osteoporosis in men - preliminary study

Conditions: Osteoporosis

Summary: this study is aimed to evaluate the roles of specific mirnas in osteoporosis in men.

in the past, osteoporosis is usually viewed as a woman disease. however, men and women are shown to lose their bone mass at the same rate by more than 65 of age, and osteoporosis in men causes higher mortality in men than those in women. thus, osteoporosis in men has recently aroused public attention. androgen deficiency was the main cause leading to osteoporosis. bone structure is maintained by a dynamic balance of osteoblast-mediated bone formation and osteoclast-mediated bone resorption. androgens and androgen receptor (ar) play critical roles in regulation of bone formation and resorption. micrornas (mirnas) are non-coding small rnas and participate in regulating activities of osteoblasts and osteoclasts by postranslationally targeting certain gene expressions. mir-133 and -135 can target bmp-2, runx2, and smad5 and then regulate osteoblast differentiation. likewise, mir-141 and -200a negatively regulated osteoblast differentiation. nevertheless, the functional roles of mirnas in osteoporosis in men are still unknown. in addition, mirna are stable and can be detected in the blood as novel biomarkers for certain diseases. a recent study analyzed the levels of mirnas in circulating monocytes of 10 high and 10 low bone mineral density postmenopausal caucasian women and found mir-133a is a potential biomarker for postmenopausal osteoporosis. in comparison, the roles of blood mirnas in osteoporosis in men have not been evaluated. therefore, this study is aimed to evaluate the roles of specific mirnas in osteoporosis in men.

Eligibility criteria:
inclusion criteria: 1. twenty oriental men (mean age, 80 years; age range, 70-90 years). 2. candidates have no clinical evidence or history of focal lesions of the femur; previous hip surgery or irradiation; hip trauma; spinal trauma. 3. participants who have thoroughly understood and signed the consent form. 4. ten normal adult male (age range, 20-40 years). exclusion criteria: 1. participants with secondary causes of osteoporosis, such as thyroid, parathyroid disease, osteogenesis imperfect and osteomalacia. 2. participants with paget's disease, serious liver disease, serious renal disease (indicated by a serum creatinine concentration of more than 1.6mg/dl). 3. participants who currently or have history of using steroids or hormone replacement therapy. 4. participants who fail to sign to the consent form.

Keywords: male osteoporosis mirna biomarker
european clinical study for the application of regenerative heart valves - espoir

Conditions: Heart Valve Disease

Summary: this is a prospective, non-randomized, single-arm, multicentre surveillance study to be conducted in europe. the surveillance is designed as a study, where * espoir pulmonary valve (pv) is prescribed in the usual manner in accordance with the terms of the approval. * the assignment of the patient to a particular therapeutic strategy is not decided in advance by this surveillance protocol but falls within current practice and the prescription of espoir pv is clearly separated from the decision to include the patient in the surveillance. * no additional diagnostic or monitoring procedures shall be applied to the patients * and epidemiological methods shall be used for the analysis of collected data. evaluation of decellularized human heart valves for pulmonary heart valve replacement in comparison to current valve substitutes. safety endpoints include cardiovascular adverse events, time to re-operation, re-intervention and explantation. efficacy endpoints include freedom from valve dysfunction and hemodynamic performance.


Eligibility criteria:
inclusion criteria: * indication for pulmonary valve replacement according to current medical guidelines in heart disease. * signed informed consent of legal guardians or patients, assent of patients. exclusion criteria: * the patient has not provided surveillance informed consent. * the patient shall not suffer from * generalized connective tissue disorders (eg, marfan syndrome), or * active rheumatic disorders, or * severe asymmetric calcification of the valve ring. * the coronary arteries of the patient shall not be in abnormal position or heavily calcified. * patients shall not show hypersensitivity against sodium dodecyl sulphate (sds), sodium desoxycholate (sdc), human collagen (or other elastic fibers) or benzonase®.
use of virtual reality to reduce morphine consumption in adolescents undergoing scoliosis surgery

Conditions: Scoliosis

Summary: the objective is to evaluate the effect of the association of virtual reality sessions with usual management on the cumulative consumption of morphine equivalent post-operatively in adolescents aged 13 to 18 years who have undergone scoliosis surgery.


Eligibility criteria:
inclusion criteria: * patient between 13 and 18 years old, i.e. the age to use a virtual reality helmet according to the manufacturer's recommendations. * patient with an indication for idiopathic scoliosis surgery. * free, informed and signed consent by patients (or parents/parental guardians) and the investigator (no later than the day of inclusion and prior to any review required by the research) exclusion criteria: * patient undergoing surgery for neurological scoliosis. * impossibility to use the vr helmet (blindness, eye infection, helmet wound, epilepsy, psychiatric or cognitive disorder incompatible with vr). * history of adverse effects while wearing an vr helmet (nausea, vomiting, headache, visual disturbances) * patient with a contraindication to the use of morphinics * patient whose both parents benefit from a legal protection measure (guardianship, curatorship, safeguard of justice)

Keywords: virtual reality scoliosis surgery adolescents pain management
cryoablation for post mastectomy pain syndrome

Conditions: Post-Mastectomy Chronic Pain Syndrome (Disorder)

Summary: this is a prospective, randomized, parallel-group, treatment control trial with cross-over options performed at four sites. the purpose of this study is to assess the efficacy and safety of cryoablation therapy for the treatment of post mastectomy pain syndrome.

this is a prospective, randomized, parallel-group, treatment control trial with cross-over options performed at four sites. the purpose of this study is to assess the efficacy and safety of cryoablation therapy for the treatment of post mastectomy pain syndrome. participants will be randomized to receive cryoablation or a therapeutic peripheral nerve block injection (tpnb). all participants will be evaluated at baseline and after treatment at 10 days, 90 days, and 180 days via clinical visits. the option to undergo cryoablation or tpnb will be offered to all participants at the end of the 90 day post-procedure assessment. each subject that elects the crossover intervention will be assessed over the same time period and in an identical fashion to the initial intervention, including a final long term follow up (ltfu) assessment at 180 days post-cryoablation.

Eligibility criteria:
inclusion criteria: * status post breast surgical intervention, to include mastectomy, partial mastectomy, lumpectomy, or reconstruction * persistent pain in the distribution of the intercostobrachial nerve: the residual breast, surgical bed, ipsilateral medial arm, and/or axilla following tissue healing (\> 1 month postoperative) * positive response to local anesthetic nerve block, performed under imaging guidance. a positive response is defined as a ≥ 3 point change on a standard 11 point visual analog scale (vas) * ability and willingness to provide informed consent exclusion criteria: * active infection * underlying cervical segmentation or other cervical spinal anomaly that results in differential nerve root pressures * immunosuppression * uncorrectable coagulopathy * currently pregnant, nursing or planning to become pregnant.

Keywords: breast pain nerve pain mastectomy lumpectomy breast reconstruction
duraseal sealant post market study

Conditions: Elective Cranial Procedures With Dural Incision

Summary: duraseal dural sealant has been approved as a dural sealant by the fda for use in cranial and spinal procedures. this study was completed to further evaluate the safety of the duraseal sealant in a post-approval setting as compared to control (defined as methods typically employed by surgeons to seal the dura).


Eligibility criteria:
inclusion criteria: * patient is between 18 and 75 years of age * patient is scheduled for an elective cranial procedure that entails a dural incision * evidence of intraoperative non-watertight closure
the effect of peppermint flavored mouthwash applied to patients

Conditions: Postoperative Complications

Summary: treatment of obesity consists of diet/lifestyle modification and bariatric surgery consisting of several procedures. one of the most common complications in the early period after bariatric surgery is nausea and vomiting due to the reduction of gastric capacity. according to the guidelines of the american society of metabolic and bariatric surgery (asmbs), acid-base disorders, electrolyte abnormalities (especially calcium, potassium, magnesium, sodium and phosphorus deficiency), insufficiency of fat-soluble vitamins (adek), folic acid, iron, thiamine after bariatric surgery. and b12 deficiency etc. on the other hand, anxiety after bariatric surgery is also an important problem. it is possible to reduce nausea and vomiting by stimulating the vagal nerve. gargling, laughing, singing loudly, etc. the movements stimulate the vagus nerve by activating the muscles behind the larynx, and the vagus nerve prevents nausea and vomiting by simulating the gastrointestinal tract. with the activation of the diaphragm; the vagus nerve is stimulated, the parasympathetic nervous system is activated and cortisol production decreases, reducing stress and anxiety. the peppermint plant, which is widely used in our country, is also used as a relief in cases such as nausea, stomachache, and colds. it is expected that the nurse, who is a member of the multidisciplinary team, will be able to properly define the surgical risks and comorbidities associated with the clinical status of obesity in patients who have undergone bariatric surgery and to apply the necessary interventions.


Eligibility criteria:
inclusion criteria: 1. be between the ages of 18-65 2. having had bariatric surgery 3. absence of communication barriers 4. volunteering to participate in research 5. mental well-being exclusion criteria: 1. presence of major depression or psychosis 2. having a communication barrier 3. being transferred to another unit 4. leaving work voluntarily

Keywords: nausea-vomiting anxiety nurse biochemical parameters
impact of individual cognitive remediation for parkinson's disease

Conditions: Cognitive Impairment; Parkinson Disease

Summary: this is an interventional clinical trial that will be conducted as a pilot project. investigators hope to conduct the study to obtain at least 10 study completers. the plan is to screen 20 parkinson's disease (pd) patients attending the academic health care center (ahcc) at nyit college of osteopathic medicine clinic and enroll the eligible candidates based on the inclusion and exclusion criteria. subjects will have 11 study visits over the 11-week period. subjects cognition will be assessed using a paper-based test of memory and learning (tomal) tool. the same tool will be used to asses and compare the cognition at baseline, and end study visits. the weekly 30-mins of cognitive remediation exercises will be done using the brain. hq cognitive remediation software.


Eligibility criteria:
inclusion criteria: 1. subjects must be between 40 and 75 years old (including both ages) at the time of study screening. 2. subjects must have a diagnosis of parkinson's disease by a physician. 3. subjects must demonstrate adequate decisional capacity, in the judgment of the consenting study staff member, to make a choice about participating in this research study. 4. subjects must have been clinically stable (non-acute) for 2 weeks prior to consent; in the judgment of the investigator. 5. subjects with a cognition level between impaired and average (scaled score between 4-12 or index score between 70-110) based on tomal cognitive assessment at visit 1 6. subjects must have the visual, auditory, and motor capacity to use the intervention in the judgment of the principal investigator. exclusion criteria: 1. subjects who are participating in a concurrent research study or another interventional clinical trial 30 days prior to consenting. 2. subjects having a history of mental retardation or pervasive developmental disorder; or other co-morbid neurological disorder (e.g., epilepsy.) 3. subjects who appear to be intoxicated or under the influence of a controlled substance on any day of assessment must be rescheduled and may be discontinued based upon the discretion of the investigator 4. subjects on medications that affect the cognition in the last 12 hours prior to the study visits that assess the cognitive functions

Keywords: cognitive remediation
effects of rehabilitation programme on respiratory function in patients with acquired and intervened congenital heart disease.

Conditions: Heart Defects, Congenital

Summary: congenital heart defects (chds) are heart malformations that occur before birth, and they represent one of the leading causes of neonatal morbidity and mortality. they occur in approximately 1% of newborns and are associated with high morbidity and mortality rates. the etiology of these cardiac anomalies is mostly unknown. around 70-80% of cases are generated by the involvement of multiple affected genes combined with an environmental trigger that, when acting on a susceptible individual, promotes the expression of the damaged genome. maternal diseases during pregnancy or exposure to teratogenic substances are also implicated in the etiology.


Eligibility criteria:
inclusion criteria: * pediatric patients with a history of cardiac transplantation or acquired congenital heart disease who have undergone at least one interventional procedure or surgical intervention at least 6 months before the start of the program in a state of clinical stability, hemodynamic stability, and ecg stability. they should have residual hemodynamic defects of sufficient severity that potentially restrict participation, and their perception of fragility may be influenced by the social, family, school environment, or by the patient themselves. * children aged 6-15 years at the start of the study. * children with maximum predicted oxygen consumption (vo2 max) values \<80%, as measured in ergospirometry 6 months before the start of the intervention program. * patients for whom consultation with a pediatric cardiology specialist and pediatric rehabilitation specialist has not revealed contraindications for exercise. * children and their legal representatives should have provided informed consent and the ability to travel to the hospital center for in-person intervention. exclusion criteria: * patients with acute, inflammatory, or infectious health conditions that could pose a risk to them during the course of the program. * patients who have undergone at least one interventional procedure or surgical intervention within a period of less than 6 months before the start of the study.

Keywords: exercise physiotherapy
evaluation of a prevention program in children and teenagers at high risk for bipolar disorder (bipokid)

Conditions: Bipolar Disorder

Summary: bipolar disorder is an early onset chronic disorder. children of bipolar parents are at high risk of developping the same disorder and/or a psychopathology. early intervention focused on emotion and problem solving strategies could improve their prognosis. the main objective of this trial is to evaluate the fft (family focused therapy) efficacity. children emotional dysregulation profile will be compared before and after this cbt intervention.


Eligibility criteria:
inclusion criteria: * children and teenagers from 6 to 16 years-old * at least one biological parent with bipolar disorder * t-score cbcl-total ≥ 60 * written informed consent exclusion criteria: * active severe thymic episode * autism spectrum disorders * intellectual disability

Keywords: bipolar disorder children family focused therapy cbt