Kornimate/medical-research-clean huggingface dataset:
physiological studies in post-covid-19 syndrome, and the association with dna methylation

Conditions: Covid19; Cardiopulmonary Disease; Dyspnea; Lung Function Decreased; Epigenetic Disorder

Summary: the physiological derangements in subjects suffering from long-term symptoms following a covid-19 infection (post-covid-19 syndrome) are poorly understood and evaluated. this study will recruit subjects with a clinical diagnosis of post-covid-19-syndrome) who are scheduled for either of lung function testing, cardiopulmonary exercise testing or cardiac ultrasound. patients' symptoms will be correlated to physiological measures and compared to predicted values. in addition, in 20 patients, symptoms and physiological measures will be correlated to epigenetical alterations, or dna-methylation patterns. in addition, a subset of patients will be examined a year after the baseline testing in order to follow the progress of the disease.

the physiological derangements in subjects suffering from long-term symptoms following a covid-19 infection (post-covid-19 syndrome) are poorly understood and evaluated. for example, the extent to which subjective symptoms correlate with physiological impairments are not known. this study will recruit subjects with a clinical diagnosis of post-covid-19-syndrome) who are scheduled for either of lung function testing, cardiopulmonary exercise testing or cardiac ultrasound. patients' symptoms will be correlated to physiological measures and compared to predicted values. in addition, in 20 patients, symptoms and physiological measures will be correlated to epigenetical alterations, or dna-methylation patterns. in addition, a subset of patients will be examined a year after the baseline testing in order to follow the progress of the disease.

Eligibility criteria:
inclusion criteria: * confirmed or clinically highly suspected covid19-infection * symptom duration at least 12 weeks following first occurence of symptoms * no other disease that better could explain the symptoms than covid19 exclusion criteria: * age \<18 years * unability to perform a maximal exercise test * unability to understand written or spoken swedish

Keywords: cardiopulmonary exercise testing lung function testing echocardiography dna-methylation covid19
description of practices implemented in the birth of living children before 24 weeks of amenorrhea

Conditions: Infant, Extremely Premature

Summary: every year, at the nice university hospital, about sixty deliveries take place before 24 weeks of amenorrhea. the child is not viable because of his extreme immaturity. in most cases, a child born before 24 years of age is stillborn, but in about one in three cases, it shows signs of life such as heartbeat, breathing, gasps or limb movements. with these too small children showing signs of life, three attitudes are possible: doing nothing and waiting for this life to stop by themselves, setting up palliative care to ensure the child's comfort, or administering a medication to shorten his or her life. the attitude to have is not univocal and the feeling of the teams confronted with their management is difficult even if the goal of the caregivers is always to act as best as possible. the main objective of the study is to describe the clinical state of the child and the practices implemented in the birth room at the nice university hospital when children showing signs of life before 24 weeks of amenorrhea are born. the secondary objective is to describe caregivers' experiences, their experiences of these situations and attitudes towards children and their parents, and to identify ethical dilemmas in these situations. this study is an observational cohort study including all births of live children before 24 weeks of amenorrhea at nice university hospital for 12 months. it consists of two parts: a quantitative study describing the child's condition and caregiving practices, and a qualitative study of caregivers' experiences and the determinants of their attitudes towards the child. the investigator will coordinate the collection of the data necessary to conduct the quantitative study, and then conduct individual semi-directive interviews with each of the caregivers present at the birth of the child. the qualitative study will be based on the analysis of these interviews.


Eligibility criteria:
inclusion criteria: * child born before 24 weeks of amenorrhea (term estimated by echographic dating or by the date of the last menstrual period in the absence of ultrasound) * inscription in the birth register (so from 15 weeks of amenorrhea) * non-opposition of the parents exclusion criteria: - child transferred to neonatal intensive care unit.
diaphragmatic eventration in children : evaluation of care strategies and results in the french cohort.

Conditions: Diaphragmatic Eventration

Summary: a diaphragmatic eventration is an abnormal and permanent elevation of a portion or an entire intact hemidiaphragm. this rare pathology, found in 0.2 - 1 for every 1000 patients in large radiological series, is either congenital or acquired due to phrenic nerve palsy. most diaphragmatic eventrations are asymptomatic and discovered thanks to chest x-rays, where the diaphragmatic dome is elevated and visualized above the 4th intercostal space and sometimes up to the clavicle. computed tomography or magnetic resonance imaging confirms the eventration by visualizing the diaphragmatic muscle distended and intact, unlike a diaphragmatic rupture or hernia. surgical indications are usually due to respiratory disorders or visceral repercussions, such as gastric emptying disorders or acute accidents like gastric volvulus. surgical treatment is a phrenic plication, which can be performed via a lateral thoracotomy (classical approach), thoracoscopy or laparoscopy. when surgery is not indicated, follow up consists of regular clinical and radiological monitoring. there is, however, no consensus when it comes to their medical and surgical management due to the very low number of patients per center and per year, and the fact that very few studies specifically address this subject in the literature.

this is a retrospective multicenter descriptive cohort study based on french national healthcare data. the aim of this study is to describe the current trends in management of diaphragmatic eventrations in france in order to indentify potential risk factors for complications and to improve and homogenize practices.

Eligibility criteria:
inclusion criterion: * patients of 16 years of age and under at diagnosis with diaphragmatic eventration, treated since 2010 in a pediatric surgery care unit in france. exclusion criterion: * patients with a diaphragmatic hernia * patient's parents or legual guardian opposed to being included in the study.

Keywords: thoracoscopy laparoscopy digestive disorders restrictive syndrom
golden black seed: support of metabolic health and general wellness.

Conditions: Hyperlipidemias; Hyperglycemia

Summary: to document effects of consuming golden black seed (brand: new chapter inc.) on metabolic health and wellness in human subjects. golden black seed contains extracts from the turmeric root (curcuma longa) and black cumin seeds (nigella sativa). both botanicals have been used traditionally in asian cooking, and also in herbal medicine for reducing inflammation.

for this clinical study, human participants will be tested over a period of 8 weeks. below is a simplified diagram illustrating the involvement of each human subject, where all study participants will be tested on three different clinic days.

Eligibility criteria:
inclusion criteria: 1. adult people of either gender; 2. age 40-75 years (inclusive); 3. bmi 25-34.9 (inclusive); exclusion criteria: 1. cancer during past 12 months; 2. chemotherapy during past 12 months; 3. previous major gastrointestinal surgery (absorption of test product may be altered) (minor surgery is allowed, including previous removal of appendix and gall bladder); 4. currently consuming large doses of anti-inflammatory nutritional supplements, and unwilling to stop taking these supplements for 2 weeks prior to and during the study; 5. use of oral, inhaled or injected steroid medication within the last 6 months (for example: prednisone, dexamethasone). nasal sprays for allergies are allowed; 6. active uncontrolled auto-immune disease (for example: rheumatoid arthritis, lupus, inflammatory bowel disease, celiac disease); 7. currently experiencing intense stressful events or life changes; 8. currently in intensive athletic training (such as marathon runners); 9. women of childbearing potential, who are pregnant, nursing, or trying to become pregnant; 10. known food allergies or sensitivities related to the test products or placebo; 11. history of drug abuse during past two years; 12. participation in another clinical trial involving a consumable test product.
cbt-i as early intervention of mood disorders

Conditions: Insomnia Due to Mental Disorder

Summary: this study aims to investigate the effectiveness of transdiagnostic nurse-administered 4-session group cognitive behavioral therapy for insomnia (cbt-i) plus standard care, compared to standard care alone, for improving sleep and daytime function, enhancing recovery, preventing relapses, and reducing medication burden in patients with the first episode of mood disorders.


Eligibility criteria:
inclusion criteria: * hong kong residents * aged ≥ 18 years * able to to communicate in cantonese and write in chinese * first episode of depressive or bipolar disorders according to the dsm-5 diagnostic criteria * having received psychiatric treatment for less than 12 months * meeting the dsm-5 diagnostic criteria for insomnia disorder for at least 1 month, instead of at least 3 months, as in criterion d. exclusion criteria: * significant cognitive impairments and psychotic symptoms, based on a mini-mental state examination score of 23 or below and the positive and negative syndrome scale items on delusions, conceptual disorganization, and hallucinatory behavior at moderate severity or above * a diagnosis of schizophrenia, delusional disorder, neurocognitive disorders, or learning disability * having a highly unstable medical or psychiatric condition (including strong suicidal risk) that requires hospitalization * having an untreated sleep disorder, including narcolepsy, obstructive sleep apnea, and periodic leg movement disorder * past or current treatment with cbt-i * having a fear of speaking in a group setting or refusal to give informed consent * refuse to give informed consent

Keywords: cognitive-behavioral therapy for insomnia insomnia mood disorder
evaluating new radiation techniques for cardiovascular imaging

Conditions: Coronary Disease

Summary: title: evaluating new radiation techniques for cardiovascular imaging background: - imaging studies such as computed tomography (ct) scans involve the use of radiation to create the pictures. heart and blood vessel ct scans can cause high radiation exposure. different methods of creating ct pictures have been developed to reduce the radiation dose. researchers want to see how effective these new methods are in producing accurate ct scans. objectives: - to study new ways of taking pictures of the heart or blood vessels using computed tomography. eligibility: - adults at least 18 years of age who will be having imaging studies to help detect heart or blood vessel problems. design: * participants will be screened with a physical exam and medical history. blood samples will be taken to check kidney function. * participants will have a ct scan of the heart and blood vessels. a contrast agent may be used to improve the quality of the images. the scanning session may last up to 2 hours. * timing of and the need for follow up contact will depend on results from the initial scan and may be repeated to assess for late events. telephone, office contact, or other follow-up of subjects may be done after ccta to evaluate if the subject had subsequent cardiovascular testing. further follow up will be based on reported test results.

cardiac ct angiography is associated with radiation exposure. different methods of creating ct pictures have been developed to reduce the radiation dose to the subject. the purpose of this research study is to learn whether these new imaging methods are accurate or predict subject outcomes.

Eligibility criteria:
* inclusion criteria: 1. clinical indication for a coronary ct angiography exam 2. age equal to or greater than 18 years 3. able to understand and willing to sign the informed consent form 4. able and willing to provide follow-up information exclusion criteria: 1. pregnancy 2. if receiving intravenous contrast, severe renal excretory dysfunction, estimated glomerular filtration rate \< 30 ml/min/1.73m2 body surface area according to the modification of diet in renal disease criteria or as reported by the clinical lab. glomerular filtration rate will be estimated using the 2021 ck-epi equation that eliminate the use of race coefficient as reported in cris. screen failures: subjects who are screen failures can be re-enrolled once they meet eligibility criteria. rescreened participants will be assigned the same participant number as for the initial screening.

Keywords: computer tomography cardiac radiation reduction iterative reconstruction
bridging the treatment gap by expanding access to care for people with epilepsy in kenya (beacon)

Conditions: Epilepsy

Summary: this cluster randomized trial aims to learn about the effectiveness of task-sharing supported by an epilepsy medical records system (emrs) (hereafter referred to as beacon) with patient-tracking data in improving treatment adherence and retention in care in people with epilepsy in western kenya.

epilepsy is a serious neurological condition and a major cause of morbidity and mortality. globally, epilepsy prevalence is highest in sub-saharan africa, and kenya has a high disease burden. delay in treatment initiation and non-adherence increase disease-related burden in terms of low quality of life, high healthcare costs, risk for seizure-related injuries, and premature death the beacon intervention is grounded in existing evidence-based intervention. task-sharing, an intervention advocated by the world health organization and the institute of medicine. researchers will compare patients receiving the beacon intervention to those receiving usual care to see if there are any differences in treatment adherence and retention in care between the groups. researchers will test beacon's ability to: (1) improve care retention and treatment adherence; and (2) reduce seizure severity and perceived stigma and improve quality of life (qol). the cost-effectiveness of the intervention will also be assessed. data will be collected at baseline, 12 and 18 months (if warranted). this project will also build clinical and research capacity for epilepsy work in western kenya.

Eligibility criteria:
inclusion criteria: * individuals ≥12 years * residents of busia or trans nzoia county * diagnosed with possible epilepsy through initial screening and confirmed diagnosis by an epilepsy-trained professional with the beacon project or physician * have a diagnosis of epilepsy but are not adherent to antiseizure medication treatment. exclusion criteria: * individuals receiving care from a neurosurgeon or neurologist for a serious brain disorder * unable or unwilling to provide voluntary informed consent or assent (12-18 years)
study of glycopyrronium in subjects with axillary hyperhidrosis

Conditions: Hyperhidrosis

Summary: the study is a randomized, double-blind, vehicle controlled, parallel group study, designed to assess the efficacy and safety of glycopyrronium topical wipes, once daily, compared to vehicle in subjects with axillary hyperhidrosis.

this is a randomized, double-blind vehicle controlled study to assess the efficacy and safety of glycopyrronium topical wipes compared to vehicle in subjects with axillary hyperhidrosis. safety will be assessed through lab tests, ecg, physical exams and vital signs.

Eligibility criteria:
inclusion criteria: * male or female ≥ 9 years of age. * primary, axillary hyperhidrosis of at least 6 months duration. * hyperhidrosis disease severity scale (hdss) of 3 or 4 at baseline. * axillary sweating daily diary (asdd) ≥ 4 at baseline. * sweat production of at least 50 mg over 5 minutes in each axilla assessed gravimetrically. exclusion criteria: * prior surgical procedure for hyperhidrosis. * prior axillary treatment with an anti-hyperhidrosis medical device (approved or investigational). * prior treatment with botulinum toxin (e.g., botox®) for axillary hyperhidrosis within 1 year of baseline/day 1. * previous active treatment in the dermira drm04-hh01 or drm04-hh02 clinical trials. * axillary use of nonprescription antiperspirants within 1 week or prescription antiperspirants within 2 weeks of baseline. * subjects on new or regimens of psychotherapeutic medications that have changed within 2 months of baseline. * treatment with systemic anticholinergics within 4 weeks of the baseline visit unless dosing has been stable for at least 4 months. * other treatment with glycopyrrolate within 4 weeks prior to baseline. * secondary axillary hyperhidrosis or presence of a condition that may cause secondary hyperhidrosis. * history of sjögren's syndrome or sicca syndrome. * history of glaucoma, inflammatory bowel disease, toxic megacolon, or febrile illness. * men with a history of urinary retention requiring catheterization due to prostatic hypertrophy or severe obstructive symptoms of prostatic hypertrophy. * history or presence of ventricular arrhythmias, atrial fibrillation, atrial flutter. * other systemic diseases or active uncontrolled infections, or any other condition which, in the judgment of the investigator, would put the subject at unacceptable risk for participation in the study.
cellular dynamics of subcutaneous fat distribution in obese women

Conditions: Obesity; Metabolic Syndrome

Summary: the body shape of obese women varies between having the majority of fat either above the waist ("apple" shape) or below the waist ("pear" shape). the study will investigate what restricts: apple"-shaped women from being "pear"-shaped at the cellular level. since "pear" shaped women tend to have better health, this study will open the door to future research in regulating body shape and thus improving health.

adipose tissue expandability and the distribution of stored fat in the body are stronger predictors of health risk. a better understanding of the factors that determine regional fat mass growth may lead to developing new strategies for prevention or treatment of metabolic complications of obesity. the objective of this proposal is to study the responsiveness of different fat depots to adipogenic stimulation in upper-body and lower-body obese women.

Eligibility criteria:
inclusion criteria: * you are a pre-menopausal woman between 18-40 years of age * your body mass index (bmi, weight-to-height2 ratio) is 27 - 38 kg/m2, inclusive * the ratio of your waist-to-hip circumferences is either \>0.84 ("apple"-type body shape) or \<0.77 ("pear"-type body shape) * you are willing to undergo a drug intervention for 16 weeks * you are willing to drink heavy water \[similar to the ordinary water that is highly enriched in the naturally occurring stable (non-radioactive) form of hydrogen, deuterium; also called deuterium-labeled water\] for 8 weeks before the beginning and during the second half of the drug intervention; you will need 24-hours access to a refrigerator for storage of the water. * you agree to use a double barrier method as a form of birth control to prevent pregnancy. oral contraceptives (birth control pills) are not allowed in the study. acceptable methods of birth control are condoms, spermicide, iud (intrauterine device, must be hormone free - see list in clinic), diaphragm and abstinence. an example of a double barrier method would be condoms plus spermicide, etc. exclusion criteria: * you have gained or lost more than 4.5 lb (2 kg) in the last 3 months * you have had significant changes in the diet or level of physical activity within the past month * you have a blood sugar of greater than 100 or a diagnosis of diabetes. * you have abnormal liver enzyme values from your blood work * you have a history of heart, kidney, lung, liver, and thyroid disease * you have an average blood pressure \>140/90 at your screening visit * have you had a positive test for human immunodeficiency virus (hiv), hepatitis b or hepatitis c? * you require chronic use of medications including diuretics, steroids, thyroid hormones, and adrenergic-stimulating agents (bronchodilators, nasal decongestants)

Keywords: obesity fat distribution adipogenesis adipocyte preadipocyte ectopic fat
sublingual methadone for the management of cancer breakthrough pain

Conditions: Cancer; Pain

Summary: a dose titration protocol for sublingual methadone hydrochloride for the management of cancer-related breakthrough pain to find the optimal dose.

this is a dose titration protocol for sublingual methadone hydrochloride for the management of cancer-related breakthrough pain to find the optimal dose.

Eligibility criteria:
inclusion criteria: * \> 18 years of age * experiences episodes of breakthrough pain which respond to opioid therapy * controlled baseline pain * cognitive status sufficient for accurate completion of assessment form * willing to provide written informed consent * ability to hold a volume of 1 cc of water under the tongue for 5 minutes exclusion criteria: * currently or has received methadone during the previous week * recent history of substance abuse * severe respiratory impairment or other contraindications to opioids * recently received therapies that had the potential to alter pain intensity or response to analgesics * symptomatic anemia

Keywords: cancer pain breakthrough pain methadone dose titration sublingual route of administration cancer related pain currently taking narcotics