Kornimate/medical-research-clean huggingface dataset:
sleep study among inpatients with tbi in an acute rehabilitation hospital

Conditions: Motor Learning in TBI

Summary: the purpose of this research study is to better understand how a daytime nap after training on a motor skill after brain injury improves performance compared with the same amount of time after training spent awake and resting.


Eligibility criteria:
inclusion criteria: * must have a traumatic brain injury. * must have been a kessler institute for rehabilitation inpatient for at least three days. exclusion criteria: * bilateral arm fractures, cellulitis or other conditions that prevent safe wearing of the watchpat-200/actigragh. * movement disorder or spasticity affecting both upper extremities * patients who are ventilator-dependent. * patients who are on contact precautions for c.diff or other highly contagious diseases. * patients with neurological disorders other than tbi.

Keywords: motor learning tbi
radiofrequency ablation in treating patients with refractory or advanced lung cancer

Conditions: Lung Cancer; Malignant Mesothelioma; Metastatic Cancer; Thymoma and Thymic Carcinoma

Summary: rationale: radiofrequency ablation uses high-frequency electric current to kill tumor cells. ct-guided radiofrequency ablation may be effective treatment for lung cancer. purpose: phase ii trial to study the effectiveness of radiofrequency ablation in treating patients who have refractory or advanced lung cancer.

objectives: * determine the safety and toxicity of radiofrequency ablation in patients with refractory or advanced pulmonary malignancies. * determine the efficacy of this treatment, in terms of local control, in these patients. * determine whether ct scan is a reasonable imaging assessment tool for treatment delivery and follow-up in these patients. outline: patients undergo percutaneous ct-guided radiofrequency ablation directly to the tumor over 2 hours. patients are followed at 1, 3, 6, and 12 months. projected accrual: a total of 30 patients will be accrued for this study.

Eligibility criteria:
inclusion criteria: * diagnosis of a primary or secondary intrathoracic malignancy * any cell type or origin * involving the intrapulmonary, mediastinal, or pleural/chest wall * inoperable primary or metastatic cancer to the lung * refractory to or not amenable to conventional therapy (e.g., surgery, chemotherapy, or radiotherapy) * single or multiple lesions that are non-contiguous with vital structures or organs such as: * trachea * heart * aorta * great vessels * esophagus * less than 5 cm in largest dimension * accessible via percutaneous transthoracic route * hepatic: * coagulation profile normal

Keywords: recurrent non-small cell lung cancer recurrent small cell lung cancer recurrent malignant mesothelioma recurrent thymoma and thymic carcinoma stage iiib non-small cell lung cancer stage iv non-small cell lung cancer pulmonary carcinoid tumor lung metastases
estimation of the vq11 auto-questionnaire, to follow patients with chronic obstructive pulmonary disease

Conditions: COPD

Summary: the purpose of this study is to estimate the capacity of the auto-questionnaire of quality of life, vq11, to follow the evolution of patients with copd (chronic obstructive pulmonary disease) in stable state (without exacerbation in the previous 6 weeks) (3 months +/-15 days) during the implementation of a labd (long-acting bronchodilator) treatment. the main objective is to compare the total score of the vq11 auto-questionnaire before and after labd. a decrease of 5 points of the total score mimicking an improvement in the quality of life linked to health, specifically in the copd.

evaluation of the vq11 auto-questionnaire of quality of life in pneumology investigation, during the implementation of a long-acting bronchodilator treatment of patients with copd. two visits per patient are planned: v1: after complete information and collection of the written consent, the pulmonologists ask the patients participating in the study to fill out the vq11 questionnaire, 2 visual analogical scales concerning the dyspnoea and the physical activity, the short ipaq version and the respiratory questionnaire of the saint georges hospital. rfe (respiratory functional exploration) is also realized during this medical exam. v2 (3 months after the treatment setup, at day90 ± 15): the pulmonologists ask the patients participating in the study to fill out the vq11 questionnaire, 2 visual analogical scales and likert scales concerning the dyspnoea and the physical activity, the short ipaq version and the respiratory questionnaire of the saint georges hospital. rfe (respiratory functional exploration) is also realized during this medical exam. inclusion period : 6 months; study participation period / patient : 3 months; complete study duration : 9 months

Eligibility criteria:
inclusion criteria: * copd patient with stage ii, iii ou iv justifying a labd * patient in stable state (without exacerbation in the previous 6 weeks) * clinical criteria: dyspnoea stage i ou more (mmrc scale) * adult over 18 years old. * patients naïve from labd treatment. exclusion criteria: * other associated pathology (bronchiectasia...) * heart disorder with a prevailing role in the dyspnoea * cardiac decompensation in the previous year * pregnancy and lactating * women in genital activity without efficient contraception method (iud or estrogen-progestin pill) * lack of social insurance * patient non compliant to protocol, at the investigator's appreciation * simultaneous participation to other clinical trial. * adult under judicial protection (tutor or curator).

Keywords: vq11 questionnaire copd lbd
laparoscopic segmental bowel resection for deep infiltrating colorectal endometriosis

Conditions: Endometriosis

Summary: this study is executed to evaluate the outcome on quality of life, pain, sexuality, pregnancy rate and recurrence rate after a fertility sparing multidisciplinary co2 laser laparoscopic radical excision of deep infiltrating colorectal endometriosis with a bowel resection.

patients all women (n=45) who had undergone fertility sparing co2 laser laparoscopic radical excision of deep infiltrating endometriosis with bowel resection were selected retrospectively from the list of all patients (n=more than 500, of whom slightly more than 50% with endometriosis) operated at the leuven university fertility centre (lufc) between september 2004 and september 2006. questionnaires all 45 patients were asked to complete the oxford endometriosis quality of life questionnaire (27), a sexual activity questionnaire (28), visual analogue scales (vas) for dysmenorroe, chronic pelvic pain and deep dyspareunia, and to answer questions about medication and fertility, to compare their status before surgery and at the moment of the evaluation (december 2008).

Eligibility criteria:
inclusion criteria: * patients suffering from deep infiltrating endometriosis with colorectal extension * who had undergone co2 laser laparoscopic radical excision of the endometriosis * with bowel resection performed by the colorectal surgeon * between september 2004 and july 2006. exclusion criteria: * patients without bowel resection

Keywords: colorectal endometriosis deep infiltrating endometriosis dysmenorroe dyspareunia quality of life
progressive cervical isometric exercises versus scapular stabilization exercises in text neck syndrome

Conditions: Neck Syndrome

Summary: the aim of this study is to investigate the effects of progressive cervical isometric exercises and scapular stabilization exercises on pain, rom and disability in young adults with text neck syndrome.

text neck or turtle neck posture is the latest term coined by dr. dean l. fishman that demonstrates the repeated stress, injury, and pain in the neck due to having the head in a forward position by excessive use of cell phones or hand-held mobile devices for a prolonged time. the use of mobile devices is becoming a concern especially in children, recent numbers are very alarming and according to surveys 87% of teenagers in america and 79% of teenagers in the uk are mobile phone owners and are greatly affected by them, these numbers have skyrocketed by recent covid-19 pandemic as the social distancing and closure of the school, colleges and offices have pushed us to work from home and it increases the prevalence of text neck syndrome. this study is unique in that as it investigate the effect of two different treatment plans for turtle neck syndrome.

Eligibility criteria:
inclusion criteria: * individuals using mobile phones for more than 6-8 hours. * participants both male and female of age between 18 to 28 years * participants with neck pain (\>7 weeks) * participants with ndi score above 15/50 (10% or higher) or * participants with nprs score above 3 exclusion criteria: * specific causes of neck pain (conditions with neurological involvement such as myelopathy with weakness, numbness and sensory loss, cervical disc prolapse, and cervical spinal stenosis) * previous neck and upper limb surgery. * history of cervical trauma (whiplash disorder), fractures, dislocations. * history of congenital torticollis, frequent migraine, carcinoma, acute pain and inflammation, torticollis, unstable/acute osteoarthritis, any recent fracture, vertigo, vertebrobasilar insufficiency, chronic heart disease, myocardial infarction or pregnancy

Keywords: progressive cervical neck isometrics scapular stabilization exercises pain rom text neck syndrome turtle neck syndrome disability
value of flt-pet before and during radiotherapy in head and neck tumors

Conditions: Head and Neck Neoplasms

Summary: tumor cell proliferation and repopulation contribute to resistance to radiotherapy in head and neck cancer. up to now, this characteristic is mostly assessed using biopsies acquired during inspection under general anaesthesia before treatment. 18f-flt-pet (positron emission tomography) is a non-invasive imaging method showing areas of active proliferation. the aim of this study is to assess the value of the functional information gained by 18f-flt-pet for radiotherapy planning and early tumor response assessment. prior to radiotherapy, a planning ct-scan and a 18f-flt-pet scan are acquired. after approximately two weeks of radiotherapy a further pet scan is obtained.


Eligibility criteria:
inclusion criteria: 1. stage ii - iv squamous cell carcinoma of the head-and-neck region, treated with radiotherapy or radiochemotherapy with curative intent. 2. 18 years or older 3. informed consent exclusion criteria: 1. patients who have undergone surgery as primary tumor therapy. 2. patients treated with palliative intent. 3. pregnancy

Keywords: cell proliferation pet radiotherapy
study to evaluate the efficacy and long-term adherence of spondyloarthropathies(spa) patients on enbrel

Conditions: Spondyloarthrosis

Summary: this study is to evaluate local data in iraqi patients with spondyloarthropathies on enbrel treatment with regards to efficacy and adherence using data from the baghdad teaching hospital (rheumatology center)


Eligibility criteria:
inclusion criteria: * diagnosed spa patients * 18 years of age and older. * did not receive previous other biological treatments. * patients have at least 1 year on enbrel. exclusion criteria: * had previously used another biological treatments. * use of etanercept for less than 1 year duration.
the comparative study on rh-endostatin (endostar®) continuous intravenous infusion and routine i.v in combination with gp regimens for phase iii b/iv squamous cell lung cancer and biological markers exploration.

Conditions: Lung Cancer

Summary: endostar is a anti-angiogenesis product and has been launched in china . the efficacy and safety have been defined. however, the compliance is unsatisfactory since routine i.v of endostar is needed for 3 to 4 hours daily during one cycle of 14 days. the continuous intravenous infusion by using venous pump can improve the compliance.the comparative study in efficacy and safety has not been done concerning continuous and routine i.v.in addition, what patient can be benefited from endostar have not been investigated. the biological markers, such as circulating endothelial cells，cecs, will be explored in the study.


Eligibility criteria:
inclusion criteria: 1. primary lung squamous carcinoma confirmed by cytology and histology, excluding sputum examination. 2. phase iiib /iv based on iaslc 2009 tnm criteria. 3. at least one measurable tumor based on recist 1.1 ( longest diameter: ≥20 mm by ct scan or 10 mm by spiral ct ) 4. male or female, age≥18 or ≤75 years old 5. ecog ps: 0 or 1 6. estimated time of survival: ≥ 3 months 7. suitable hematologic function: anc≥2×109/l, plc≥100×109/l and hb≥9 g/dl 8. suitable liver function: total bilirubin≤normal uln, ast and alt≤2.5×normal uln, alp≤5×normal uln. 9. suitable renal function: cr≤normal uln,or ccr≥60 ml/min 10. ekg normal 11. without no healing wound 12. no history of anti-cancer therapy, or adjuvant/neo-adjuvant chemotherapy for non-metastatic tumor finished for more than 6 months before enrolment. 13. for the female subject with productive ability, urine pregnancy test must be done and is negative within 7 days before enrolment. 14. no history of serious allergic to biologic agents, especially e.coli products 15. the authorized icf must be signed exclusion criteria: 1. woman in pregnancy and breast-feeding, or having productive ability without contraception. 2. having the serious acute infection uncontrolled or purulent/chronic infection with unhealed wound. 3. having the serious heart disease, including congestive heart failure, uncontrolled high-risk arrhythmia, unstable angina, myocardial infarction, valvular disease, and refractory hypertension. 4. having uncontrolled nervous or mental disease with low compliance and reluctance to description of response; uncontrolled primary brain tumor or other metastatic brain cancer with obvious intracranial hypertension or mental symptoms. 5. having the tendency of bleeding, such as fib\<2g/l 6. being receiving adjuvant chemotherapy. 7. on other conditions investigator considers, the subject is not fitful to participate the trial.

Keywords: efficacy and safety
interventions to decrease cre colonization and transmission between hospitals, households, communities and domesticated animals

Conditions: Antibiotic Resistant Infection; Carbapenem-Resistant Enterobacteriaceae Infection

Summary: carbapenem resistant enterobacteriaceae (cre) colonization of patients discharged from hospitals is a source of transmission to the community. in a cluster randomized controlled trial the effect of a bundle of interventions will be assessed on cre transmission from cre+ index patient discharged from hospital to household (hh) members. the districts in two provinces will be randomized to intervention or control. an information, communication, education and hygiene intervention, developed in collaboration with local health authorities, will aim to improve hygiene and decrease antibiotic (ab) use. the effect will be evaluated on cre transmission between hh members, livestock and environment through consecutive cre screening using fecal and hospital effluent samples cultured on carbapenem selective media. knowledge, attitudes, practice surveys with smartphones will assess health seeking, ab use and hygiene adherence, hence detecting the effect of interventions. if transmission of cre +/- colistin resistant enterobacteriaceae (core, common among livestocks) is detected the source will be investigated including livestock and food, targeted information will be given and evaluated. in hospitals the effect of cohort care will be assessed on cre acquisition, hospital acquired infection, treatment outcome, costeffectiveness and contamination in sewage water. mechanisms of resistance, relatedness of cre isolates in different one health departments, and rate of cre transmission from humans to animals and vice versa, will be assessed through whole genome sequencing (wgs).


Eligibility criteria:
inclusion criteria: * all patients under 2 years old at the selected hospital are highly appreciated to join the study. exclusion criteria: * patients not from the selected hospital and individuals outside the selected province
impact of nebulized dornase alpha on mechanically ventilated patients

Conditions: Atelectasis; Ventilation, Mechanical

Summary: the investigators hypothesized that dornase alpha, administered twice a day (bid) by in-line nebulizer, would improve oxygenation, compliance, and time to extubation in adult patients receiving mechanical ventilation.

background: lobar or segmental collapse of the lung in mechanically ventilated patients is a relatively common occurrence in the intensive care unit. available treatments are either labor or time intensive and not highly effective. methods: we conducted a randomized, placebo-controlled, double-blind pilot study to determine whether nebulized recombinant human dornase alpha (pulmozyme, genentech) improves radiologic and clinical outcomes in ventilated patients with lobar atelectasis. outcomes of interest were chest radiograph score, oxygenation, lung compliance, and rate of extubation over the first 5 days. the groups consisted of 14 intervention patients and 16 control patients. they were similar with respect to basic demographics, age, gender, and use of therapeutic modalities relating to lung function. baseline average chest x-ray scores, pa02/fi02 ratios, and static compliance were not significantly different. analysis was limited to the first 5 days. results: there was a significant improvement in oxygenation for the intervention group at day 5 (p=0.03). there were no significant differences in chest radiograph score, compliance, or rate of extubation. two patients died in the intervention group, whereas none died in the control group (ns). conclusions: these pilot data suggest that inhaled dornase alpha appears to be safe and is associated with improved oxygenation 5 days after initiation of therapy in mechanically ventilated patients compared to placebo. larger studies are needed to confirm these findings and determine if this intervention decreases icu morbidity and mortality.

Eligibility criteria:
inclusion criteria: * current ventilator use * onset of lobar or whole lung collapse over the previous 12 hours * age greater than 18 exclusion criteria: * quadriplegia or debilitating neuromuscular condition * chronic ventilator dependence * pneumothorax * frank hemoptysis * elevated intracranial pressure * intracranial bleed * pregnancy or active nursing * concurrent use of other investigational drugs * history of allergy to pulmozyme®, chinese hamster ovary-derived biologics, or any of the components of the active or placebo formulations.

Keywords: mechanical ventilation extubation dornase alpha oxygenation chest x ray
comparing urolift experience against rezūm

Conditions: Benign Prostatic Hyperplasia

Summary: c.l.e.a.r. study is poised to compare the patient experience post procedure, including catheterization needs as well as retreatment and bph medication rates following treatment with either the urolift® system or rezūm™ system through 12 months.

patients will be randomized to either the urolift or rezum arm. post-procedure, subjects who receive a catheter between post-procedure and prior to discharge, will return to office to complete a voiding assessment. all subjects will be expected to complete questionnaires and assessments, as part of soc (varies by institution), at day 3, day 7, 2 weeks, 1 month, 3 months and 12 months post-procedure.

Eligibility criteria:
inclusion criteria: 1. male gender 2. age ≥ 50 years 3. diagnosis of symptomatic bph 4. prostate volume 30cm3 ≤ 80cm3 5. willing to sign study informed consent form exclusion criteria: 1. current urinary tract infection 2. current catheter dependent urinary retention or pvr \>= 500 ml 3. urethra conditions that may prevent insertion of delivery system into bladder 4. previous bph surgical procedure 5. urinary incontinence presumed due to incompetent sphincter 6. current gross hematuria 7. patients with a urinary sphincter implant 8. patients who have a penile prosthesis 9. currently enrolled in any other investigational clinical research trial that has not completed the primary endpoint
effects of glp-1 receptor agonist on fat redistribution and inflammatory status

Conditions: Obesity

Summary: glp-1 receptor agonists promote fat redistribution in obese women with type 2 diabetes, reduce liver fat content, improve the inflammation state

as a treatment for type 2 diabetesglucagon like peptide -1 (glucan-like peptide-1, glp-1) receptor agonists plays the role of promoting insulin secretion, inhibiting glucagon secretion，and also has the central and peripheral effects,it can inhibit appetite,reduce weight.glp-1 receptor agonists promote fat redistribution in obese women with type 2 diabetes, reduce liver fat content, improve the inflammation state

Eligibility criteria:
inclusion criteria: * clinical diagnosis of overweight and type 2 diabetes mellitus exclusion criteria: * poor body condition (severe liver and kidney dysfunction) * unknown causes of pancreatitis, chronic pancreatitis, pancreatic resection, stomach operation, malignant tumor, previous use of systemic corticosteroids (local or inhalation of exceptions) heart function or niacin, incomplete * serious endocrine disease * genetic disease

Keywords: obesity; fat distribution; inflammation
study on lipid profile changes in plasma and intestinal mucosa of patients with inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases

Summary: this study aimed to demonstrate the characteristic lipid profile changes in patients with inflammatory bowel disease.

this study aimed to demonstrate the characteristic lipid profile changes in patients with inflammatory bowel disease. the investigators followed up with patients with different stages of ibd and collected plasma and lesion tissues from patients and healthy volunteers for lipid metabolism-related substances to assess the changes in lipid metabolism in patients with different stages of ibd and their impact on disease.

Eligibility criteria:
inclusion criteria: * patients with inflammatory bowel disease; aged 18-80 years; all cases agreed to participate in the study. * healthy volunteers who agreed to participate in the study. exclusion criteria: * patients with severe heart disease; patients with severe kidney disease; patients with low blood pressure; patients with severe infections such as sepsis or pneumonia; patients who have used immunosuppressants such as 6-mercaptopurine, imidazole thiopurine, and cyclosporine within a short period, and women during pregnancy; patients who are post-colon resected; patients who disagreed to participate in the study.

Keywords: ibd lipid metabolism activity