Kornimate/medical-research-clean huggingface dataset:
oxidoreductive balance and lysosomal activity in cancer patients.

Conditions: Neoplasms; Antioxidants; Oxidative Stress; Lipid Peroxidation; Inflammation; Lysosome Alteration

Summary: the research aims to determine the parameters of oxidative stress and inflammatory processes and compare these parameters with the image obtained using positron emission tomography (pet) with 2-deoxy-2-\[fluorine-18\]fluoro- d-glucose (18f-fdg) integrated with computed tomography (ct) in the group of oncological patients.

fdg pet/ct is very sensitive imaging tool for the detection of neoplasms. neoplasm tissue is characterized by a much higher level of metabolism than healthy tissues, therefore a 95% cases of use the method regard oncology. fluorodeoxyglucose (fdg) is absorbed by patients' organism as glucose but it does not undergo metabolism. the increased degree of fdg accumulation in tissue means its higher metabolic activity. fdg accumulates in the tumor tissue and radiates enabling its detection but the substance has not been shown to be harmful to patient at doses used in the diagnostics. tumor formation is a multi-stage process in which the phases of initiation, promotion and progression are distinguished. neoplastic transformation of healthy cells is associated with disturbances of the cell cycle caused by mutations of proto-oncogenes (activation of cell division) and/or suppressor genes (blocking cell division) and mutator genes (protecting the dna against damage or its repairing) under the influence of various factors. increasing data indicate that one of the most important factors initiating neoplasm are reactive oxygen species (ros) and oxidative stress. mechanisms responsible for induction of oxidative stress in cancer cells are not fully explained. it is known that they are closely related to inflammation, as well as intense cellular metabolism associated with continuous proliferation, mutations in the genetic material and dysfunctions in the mitochondrial respiratory chain. in this study a number of markers of oxidative stress and inflammation are planned to be determined including: the activities of antioxidant and lysosomal enzymes, as well as concentrations of lipid peroxidation products and low molecular weight antioxidants. the pet/ct imaging will be performed as part of standard medical procedures related to the diagnosis and monitoring of cancer diseases at the oncology center in bydgoszcz, poland.

Eligibility criteria:
inclusion criteria: - sign informed consent form for participation in the study exclusion criteria: * other diseases, * bad feeling of the studied individual on the day of the study, * the participants will not be minor and incapacitated persons, soldiers, prisoners and persons dependent in any way from the investigators.

Keywords: positron emission tomography computed tomography fluorodeoxyglucose f18 cancer superooxide dismutase catalase glutathione peroxidase malondialdehyde conjugated dienes acid phosphatase cathepsin d alpha-1-antitrypsin arylsulfatase 8-iso-prostaglandin f2alpha 4-hydroxynonenal total antioxidant capacity vitamin a vitamin e
study of the metabolic parameters of uterine muscle cells

Conditions: Ischemia

Summary: to date, no transplant has allowed pregnancy from a donor in a state of brain death. one of the main reservations lies in the ischemic properties of the uterine graft between the sampling time and the grafting time. investigators propose to carry out a prospective monocentric study at the university hospitals of strasbourg in 2018/2019: the objective would be to study physiologically the time of ischemia of the uterine muscle the objective is to carry out a preparatory study on healthy uteri to study the ischemic properties of uterine muscle from living markers: study of mitochondrial respiration and free radical production on uterine muscle samples if the markers are reliable, they would then be used to measure the ischemia of whole uteri collected at the end of the multi-organ retrieval process from donors in a state of brain death and stored in tissue survival media.


Eligibility criteria:
inclusion criteria: * - adult patient * patient benefiting from the routine management of a programmed hysterectomy by vaginal, laparoscopic or laparotomy for benign pathologies (fibroma, adenomyosis, genital prolapse,...) within the cmco * patient consenting to the use of cells from her uterus for incineration for research purposes * patient giving her consent for the use of her medical data for the purposes of this research. * patient agreeing to participate in the study exclusion criteria: * - patient refusing to participate in the study * patient under the protection of justice * patient under guardianship or curatorship * suspicion of gynaecological malignant pathology * pregnant or breastfeeding woman * impossibility to give the subject informed information (difficulties in understanding the subject...)

Keywords: hysterotomy uterine muscle cells ischemia cold ischemia
study of the effects of osmotic-release oral system (oros) methylphenidate (concerta) on attention and memory

Conditions: Attention Deficit Hyperactivity Disorder

Summary: this study investigates whether oros-methylphenidate improves performance on different aspects of attention and memory in children with attention-deficit hyperactivity disorder (adhd).

this study investigates the effect of osmotic-release oral system (oros)-methylphenidate, a long-acting stimulant, on multiple dimensions of attention and on working memory. specifically, we will investigate the following two hypotheses: (1) oros-methylphenidate will result in improved performance on measures assessing multiple domains of attention, including sustained attention, attentional control, selective attention, and divided attention, and (2) oros-methylphenidate will result in improved performance on measures of working memory. in addition we will use the study to collect pilot data on whether the magnitude of the effect of oros-methylphenidate varies across the different components of attention and working memory and whether improvement across any of these measures is helpful in predicting parent or teacher ratings of improvement.

Eligibility criteria:
inclusion criteria: * meets diagnostic and statistical manual-iv edition (dsm-iv) criteria for adhd.combined type * parent and teacher ratings \>85 percentile on inattention and/or hyperactivity/impulsivity scales * estimated intelligence quotient (iq) \> 80 on wechsler abbreviated scale of intelligence or similar iq test exclusion criteria: * past or current diagnosis of tourette syndrome or chronic tic disorder, pervasive developmental disorder (pdd), cerebral palsy, head injury requiring hospitalization, psychotic disorder, hypertension, glaucoma, cardiovascular disease, severe narrowing of the gastrointestinal tract, or epilepsy * current diagnosis of bipolar disorder, obsessive-compulsive disorder serious enough to warrant separate treatment, suicidal or homicidal behavior or ideation * use within 14-days of a monoamine oxidase inhibitor * history of side effects on any methylphenidate preparation that required stopping the medication * inability to swallow a capsule or tablet * chronic treatment with coumarin, clonidine, or tricyclic antidepressants

Keywords: attention deficit hyperactivity disorder methylphenidate attention working memory
effects of a home-based exercise program on functional capacity and quality of life in heart failure patients

Conditions: Chronic Heart Failure

Summary: heart failure (hf) is a multisystemic disease leading to exercise intolerance and fatigue. supervised physical training improves functional capacity, quality of life and reduces hospital admissions in hf patients. in this way, home physical training may be a good alternative to patients who, for any reason, cannot perform supervised training. objective: to asses the effects of a home-based training program on functional capacity, sedentary lifestyle and quality of life of patients with chronic hf compared to supervised training.

after agreement with the written informed consent, subjects with heart failure (left ventricle ejection fraction bellow or equal 40%) will be included in this study. they will be randomized in two groups: home-based and supervised exercise groups. the two groups will be submitted to a twelve-week combined exercise program of aerobic and peripheral muscle training. all volunteers will be assessed at baseline and after twelve weeks of intervention. peripheric and respiratory muscle strength as well the 6mw analyses were assessed also at 4 and 8 weeks after baseline.

Eligibility criteria:
inclusion criteria: * chronic heart failure (functional class from nyha ii and iii), * left ventricle ejection fraction bellow or equal to 40% * clinical stability during the last three months * medical release for physical training after cardiopulmonary test exclusion criteria: * uncontrolled arrhythmia * pulmonary artery systolic pressure \> 35 mmhg by the echo doppler cardiogram, * peripheral oxygen saturation \< 92% in resting condition * respiratory infection in the previous 30 days to the enrollment into the study * cognitive, neurological or orthopedic limitations

Keywords: home-based exercise functional capacity chronic heart failure
association between phthalates exposure and renal function impairment in type 2 diabetes

Conditions: Diabetes Mellitus, Type 2; Albuminuria; Cardiovascular Risk Factor

Summary: the global incidence of diabetic nephropathy (dn) is increasing, with no appreciable reduction in the percent of patients progressing toward end stage renal disease (esrd) and dialysis (tuttle et al, 2014, winocour et al, 2018). therefore, identification of modifiable risk factors and early biomarkers of progressive decline in kidney function is an urgent clinical need. phthalates are environmental and dietary contaminants with a various array of use that are identified in many consumer and industrial products; among them, di-(2-ethylhexyl) phthalate (dehp) and its metabolites (mono 2-ethylhexyl phthalate (mehp), 5oh-mehp (mehhp) and 5oxo-mehp (meohp)) are widely used (kato et al 2004, braun et al, 2013). they partially distribute to the human tissues and their urinary and serum levels are directly related; therefore, urinary concentration of phthalates is commonly used as proxy of their exposure in humans (kato et al 2004). while the association between phthalates exposure and development of t2d is currently being explored (dong et al 2017, dales et al, 2018), little is known about their role in dn. recent observations show that dehp and its metabolites are associated with a higher prevalence of low-grade albuminuria and in children exposed to higher phthalates concentrations (trasande et al, 2014, wu et al, 2018), however such association has yet to be verified in adults. the environmental ubiquity of the phthalates enhances the importance of investigating the potential relation between their exposure and different degrees of renal function. (kato et al 2004, kataria et al, 2015). given this premise, the investigators will explore this potential association in a population of subjects with t2d consecutively referring to the outpatient diabetes clinic in santa chiara hospital, pisa, enrolled on a volunteer basis. during their routine visit at santa chiara hospital outpatient diabetes clinic participants will provide the results of blood tests prescribed as per standard clinical practice along with a first morning, overnight fasting, urine sample collected in a phthalates-free container. the investigators will record the participants' clinical history, physical examination and anthropometric measurements, will measure their renal function, evaluated by egfr (calculated with the cdk-epi formula), albumin excretion, fasting glucose, hba1c%, and the exposure to phthalates, assessed by total concentrations of mehp, meohp, mehhp and adjusted for urinary creatinine. in this way, the investigators aim to point out the relationship of urinary phthalates with higher degrees of albuminuria and/or lower egfr after adjustment for all potential confounders, including therapies.


Eligibility criteria:
inclusion criteria: age 18-85 years, t2d diagnosis, t2d duration \>6 months, exclusion criteria: occurring acute clinical conditions, egfr \ 40 kg/m2.
chromosomal instability in ovarian cancer

Conditions: Epithelial Ovarian Cancer; High-grade Serous Ovarian Carcinoma; Chromosomal Instability; Somatic Copy Number Distortion; Survival Outcomes; Minimal Residual Lesions; Progression-free Survival; Overall Survival

Summary: chromosomal instability (cin) refers to the ongoing genomic change, which involves the amplification or deletion of chromosome copy number or structure. the changes rang from point mutation to small-scale genomic change and even the change of whole chromosome number. it has been reported that the characteristics of genomic rearrangement can be used as a marker of clinical outcome of high-grade serous ovarian cancer, and specific genomic rearrangement are related to the poor prognosis. in noninvasive gene detection with low coverage, patients diagnosed with ovarian cancer have deteriorating progression-free and overall survivals regardless of the tumor stage when somatic copy number distortion (scna) exceeds the threshold in plasma. the detection rate of scna increased along with the tumor stage. we enrolled those as our target patients, who are diagnosed with high-grade serous ovarian cancer and willing to take part in. the cin in peripheral cell-free dna was observed before initial treatment, after primary debulking or staging surgeries, before recurrence and during the process of recurrence treatment. our aim is to explore the application of cin in peripheral tumor dna in the detection of minimal residual lesions (mrd) after primary treatment and recurrence monitoring.


Eligibility criteria:
inclusion criteria: * confirmed of primary ovarian high grade serous carcinoma (hgsc) * aged 18 years or older * acceptance of surgical treatment for hgsc * with detailed follow-up outcomes exclusion criteria: * not meeting all of the inclusion criteria * declining to anticipate the trial
non-invasive molecular imaging of muscle structure (msot_muscles)

Conditions: Muscular Diseases

Summary: this study aims to determine hemoglobin and collagen levels in muscles before and after exercise, and over time, using multispectral optoacoustic tomography (msot). during msot, a transducer is placed on the skin similar to a conventional sonography and instead of sound, energy is supplied to the tissue by means of light flashes. this leads to a constant change of minimal expansions and contractions (thermoelastic expansion) of individual tissue constituents or molecules. the resulting sound waves can then be detected by the same examination unit.

duchenne muscular dystrophy (dmd) is one of the most common progressive childhood muscle diseases with an incidence of 1 in 3500 male newborns and is associated primarily with decreased life expectancy. pathogenetically, there is a deficiency of dystrophin, a structural protein of the sarcolemma, which is caused by mutations (usually deletions) of the dystrophin gene (xp21.3-p21.2). the result of dystrophin deficiency is a necrosis of muscle cells that are replaced by connective tissue and adipose tissue. clinical scores (6-minute walk test, 6mwt) and mri studies to characterize the degenerative changes of skeletal muscle in the early stages are available for the quantitative assessment of the disease progression as well as therapy effects, the significance of which is controversially discussed. however, the highly sensitive assessment of gene therapy effects will become increasingly important in the future. sensitive, non-invasive methods for the detection of early muscle degeneration and muscle function in the course are of great clinical and scientific importance. msot has already been demonstrated to be a potential monitoring tool in different diseases. however, it has not yet been investigated to what extent 1) previous physical activity 2) different measuring ranges at the muscle, 3) longitudinal measurements and 4) intra- and interoperative variability influences the measured results. in particular, molecular changes immediately after the 6-mwt are relevant for studies in patients with dmd. in this first pilot study, the investigators want to investigate in healthy adults, whether increased exercise changes the hemoglobin values, whether the collagen content remains constant and whether repeated measurements at different muscle positions by different investigators provide consistent results over time. this information is indispensable for future studies of children with muscular diseases in order to be able to make statements about disease progression or even therapy response.

Eligibility criteria:
inclusion criteria: * \>18 years of age exclusion criteria: * any reference to a myopathy * pregnancy * tattoo in the scanning region

Keywords: muscular diseases duchenne muscular disease msot
the relationship of adiponectin in adipose tissue, thy-1 in plaques, and inflammatory mediators with cardiac diseases

Conditions: Heart Surgery

Summary: atherosclerosis is an inflammatory process in which immune mechanisms interact with metabolic risk factors to initiate, propagate, and activate lesions in the arterial trees and is known as the main cause of coronary artery disease (cad). recently, there are more and more studies highlighted the potential importance of adipose tissue in relation to inflammation effects on cad pathogenesis. however, it remains unclear whether thy-1, adiponectin or any other inflammatory mediators in mediastinal adipose tissue contribute to cad. in this study, we aim to analyze the expression of inflammatory mediators' expression via in vitro assay (3t3-l1 cell culture) and in vivo assay (human adipose tissues).

in addition, we'd like to investigate the association of the investigators' findings with clinical atherosclerotic risks, medications (statins or antiplatelet), and blood sugar. now, we've established cell assay and successfully transformed mature adipocyte from 3t3-l1 cells. besides, there were nighty-six patients enrolled into this study. flow cytometry of thy-1 and mcp-1 concentration in cultured medium by elisa were also analyzed.

Eligibility criteria:
inclusion criteria: * coronary artery bypass grafting surgery * valvular surgery exclusion criteria: * liver disease (gpt 2 times greater than normal limits) * chronic renal insufficiency (creatinine \> 2.0 mg/dl) * neoplastic diseases * taking steroids * congestive heart failure

Keywords: cad vhd thy-1
a randomised, cross-over, nicotine pharmacokinetic and pharmacodynamic study of heated tobacco products compared to combustible cigarettes

Conditions: Healthy Volunteers

Summary: this is a randomised, cross-over, open-label, confinement study conducted in 24 adult male or female smokers of combustible cigarettes. the study investigates combustible and heated tobacco (ht) products in a cross-over design, including pharmacokinetic evaluation, subjective questionnaire assessments, as well as safety evaluation. subjects will perform a screening visit and a 5-day confinement period.


Eligibility criteria:
inclusion criteria: * reports smoking an average of at least 10 manufactured combustible (menthol or non-menthol) cigarettes per day for at least 12 months prior to screening * has a positive urine cotinine (\>500 ng/ml) at screening * has an exhaled carbon monoxide \>10 ppm at screening * a female subject of childbearing potential must use contraception * male subject must use contraception exclusion criteria: * has a history or presence of clinically significant disease or condition that, in the opinion of the investigator, would jeopardise the safety of the subject or impact the validity of the study results. * has a positive test for human immunodeficiency virus (hiv), hepatitis b surface antigen (hbsag), or hepatitis c virus (hcv) at screening * has a fever (\>38.05°c) at screening or check-in * has a history or presence of drug or alcohol abuse within 24 months of check-in * pregnant or lactating females * has used any prescription smoking cessation treatments within 3 months prior to check-in * is planning to quit smoking during the study or within the next 3 months
a pharmacokinetic/pharmacodynamic study comparing pf-05280586 to rituximab in subjects with active rheumatoid arthritis with an inadequate response to tnf inhibitors (reflections b328-01)

Conditions: Rheumatoid Arthritis

Summary: in this study, patients with moderate to severe rheumatoid arthritis who are being treated with methotrexate will receive 2 intravenous treatments with either pf-05280586 or rituxan (rituximab) or mabthera (rituximab). during the course of the study, the effects of the drugs will be assessed by sampling the levels of drug in the blood, blood cell counts, and by comparing these levels among the different treatments. safety, tolerability and immunologic response also will be evaluated throughout.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of rheumatoid arthritis * meets class i, ii or iii of the acr 1991 revised criteria * ra seropositivity * stable dose of methotrexate * inadequate response to tnf inhibitors exclusion criteria: * any prior treatment with lymphocyte depleting therapies * history of active tb infection * known or screen test positive for specific viruses or indicators of viral infection

Keywords: rheumatoid arthritis rituximab methotrexate anti-tnf
577nm micropulse laser versus 532nm subthreshold laser photocoagulation for diabetic macular edema

Conditions: Diabetic Macular Edema

Summary: this randomized, parallel controlled, clinical-trial aims to evaluate the therapeutic efficacy and safety of 577nm micropulse laser photocoagulation for diabetic macular edema compared with 532 subthreshold laser photocoagulation.

1. to evaluate the efficacy of 577nm micropulse laser photocoagulation with grid/focal treatment for diabetic macular edema. 2. to investigate influence of 577nm micropulse laser photocoagulation on structure and function of macula compared with 532nm subthreshold laser photocoagulation.

Eligibility criteria:
inclusion criteria: * aged \>18 years * patients with diabetes mellitus type 2 * diagnosed as diabetic retinopathy with clinical significant macular edema * central retinal thickness(crt) of more than 250μm as measured by optical coherence tomography (oct) * etdrs visual acuity \>19 letters (snellen equivalent of 20/400 or better) * no macular laser coagulation or surgery or medicine therapy of macular edema within the last 6 months * blood glucose was controlled steadily(hba1c≤10%) exclusion criteria: * taking part in other clinical trial within 3 months * planning panretinal photocoagulation(prp) within 3 months * performed cataract surgery in the last 3 months * accompanied with other retinal vascular disease that can lead to macular edema, for example branch retinal vein occlusion(brvo),central retinal vein occlusion(crvo) * accompanied with severe opacity of refractive media that maybe impact therapy and observation * accompanied with nystagmus * accompanied with some history that maybe interfere with result or increase the risk of patients

Keywords: diabetic macular edema micropulse laser subthreshold