Kornimate/medical-research-clean huggingface dataset:
longer-term recurrence rates in patients with bladder cancer after hexvix (cysview)fluorescence cystoscopy/turb

Conditions: Bladder Cancer

Summary: the study is intended to investigate whether the improved initial detection and resection of bladder cancer lesions in patients with non-muscle invasive bladder cancer with hexvix (cysview) fluorescence cystoscopy/turb will lead to a longer-term reduction in recurrences compared to standard white light cystoscopy/turb.

a previously completed pivotal clinical study pc b305/04 demonstrated reduced recurrence rates for patients with papillary bladder cancer who underwent hexvix (cysview) and white light cystoscopy and transurethral resection (turb) of the bladder compared to patients who underwent white light cystoscopy and turb alone. the present study is intended to investigate whether the improved initial detection and resection of bladder cancer lesions in patients with non-muscle invasive bladder cancer with hexvix (cysview) fluorescence cystoscopy/turb will also lead to a longer-term reduction in recurrences compared to standard white light cystoscopy/turb. no safety data was collected.

Eligibility criteria:
inclusion criteria: * patients of study pc b305/04 with ta or t1, that were followed for recurrence are eligible to be included in this study. exclusion criteria: * patient died during clinical study pc b305/04
a prospective study of the interfuse t(tm),

Conditions: Low Back Pain

Summary: the purpose of this post-approval study is to demonstrate that the interfuse t modular lumbar interbody device is at least equal in safety and efficacy to other (standard of care) tlif devices.

the primary objective of this post-market study is to collect data to asses the long term outcome of the interfuse t (tm) device in \[patients undergoing interbody fusion. the primary endpoints of the investigation will include assessment of the maintenance of disc height and fusion rates demonstrated by radiographic evidence based on plain radiographs. fusion is defined as a bone bridging across the disc space at the level of the interfuse t implant. length of stay, implant migration, implant subsidence, re-operation rate and opioid use will be recorded. it is anticipated that outcomes with the interfuse t interbody fusion device will be comparable to or better than the historical published results for other non-modular tlif devices and to the control device used concurrently in the study

Eligibility criteria:
inclusion criteria: * meets indications for an interbody fusion (determined by the study investigator) * has documented conservative (non-operative ) treatment for at least 3 months * has a vas back pain of \> or = 60mm * has an odi \> or = 40% * at least 18 years of age and skeletally mature * willing and able to comply with study requirements * patient's condition is appropriate for surgery * agreed to participate in study exclusion criteria: * has severe osteoporosis or osteopenia * grade 3 or higher spondylolisthesis * diffuse multilevel neoplastic disease such that no adjacent normal segment exists for engagement or instrumentation * body mass index (bmi) \> 40 * patient has active infection * patient is pregnant or planning to become pregnant * patient is mentally ill or has history of drug abuse * patient has known allergy to polyetheretherketone (peek), stainless steel or tantalum * patient is currently enrolled in an investigational spine study * has rheumatoid arthritis, ankylosing spondylitis or other autoimmune disease * patient bhas symptomatic fibrous arachnoiditis

Keywords: intervertebral disc degeneration bone disease musculoskeletal disease spinal disease
investigate and predict aortic & thoracic surgery persistenet postsurgical pain

Conditions: Persistent Postsurgical Pain

Summary: this is an observational clinical study aiming to further the wider understanding of patients who develop persistent pain after thoracoabdominal aorta surgery, a surgical cohort who are disproportionately affected. this will be undertaken through a prospective biopsychosocial characterisation of the phenotype of patients undergoing this operation. increasing numbers of patients are undergoing surgery on the chest for treatment of heart or lung cancer disease. over the last twenty years, the medical community has become increasingly aware of the long-term effect of this surgery in producing persistent pain, approximately half of all survivors are still in pain around their surgical incision at three months postoperatively and beyond. there is currently no accepted method for preventing this phenomenon. the nervous system mechanisms for the development of persistent pain after surgery are unclear. some studies suggest it may involve the patient's ability to dampen down pain signals travelling from the incision site to the brain. humans have an in-built system that produces opiates as well as other pain-relieving molecules in response to injury, e.g. surgery. however, this response varies hugely from person to person and may even be impacted by the psychological state of the individual at the time of surgery. some of these pain modulating mechanisms can be measured before and after surgery in patients using sensory testing, a robust and established objective method to assess patients'. identifying patients who are most at risk of a persistent pain state will allow both academics and clinicians to investigate and better target appropriate treatments. undertaking these longitudinal observational assessments will facilitate an improved mechanistic insight of the transition from acute to pathological pain, with the ultimate goal of improving outcomes for patients'.


Eligibility criteria:
inclusion criteria: * adults (over 18 years of age) undergoing elective repair of the thoraco-abdominal aorta. able to adequately understand and respond to verbal instructions exclusion criteria: * unwilling or unable to give consent, age \<18 years
factors associated with advanced hiv and poor nutrition among people living with hiv

Conditions: Advanced HIV Disease; Poor Nutriyion Among HIV Patients

Summary: aim of the work: 1. to determine the frequency of advanced hiv among plwh in assiut university hospital. 2. to assess the nutritional patterns and frequency of poor nutrition among plwh. 3. to evaluate factors associated with advanced hiv disease and poor nutrition among plwh.

human immunodeficiency virus (hiv) is an rna virus that attacks the human body's immune system, which results, in advanced cases, in expression of opportunistic infections (1). hiv infection represents a global public health burden (2, 3). in egypt, in 2022, about 34,000 people (\<0.1%) were positive for hiv (4). there is 25-30% annual increase of newly confirmed hiv cases in egypt over the last 10 years (5). the who defines advanced hiv disease as having cd4+ t-cell count \<200 cell/mm3 or having an acquired immune deficiency syndrome (aids)-related infection (stage 3 or 4 of hiv infection) regardless of the cd4+ t-cell count (1). the who reported, in 2022, that 630,000 people living with hiv (plwh) died from aids-related diseases worldwide (which is 51% fewer than those in 2010) (2, 3, 6). in egypt, the aids-related deaths increased from \<100 plwh in 1990 to \<1000 plwh in 2021 (5). plwh are usually malnourished due to opportunistic infections, poor food intake, changes in metabolic activity or chronic illnesses. malnutrition leads to more impairment of the immune system and further disease progression (7). according to 2023 global hunger index, egypt is at a moderate level of food insecurity, ranking 57 out of 125 countries. 14.4% of the egyptian population are food insecure (8). in egypt, there is lack of data about the frequency of advanced hiv disease and the nutritional status among plwh and associated factors. monitoring these factors could help in early treatment of hiv infection, prevention of further virus transmission and enhancement of the nutritional pattern among plwh.

Eligibility criteria:
inclusion criteria: * (1) newly diagnosed people living with hiv (plwh), (2) patients previously diagnosed with hiv but non-compliant to treatment. exclusion criteria: * (1) plwh compliant on art, (2) plwh who refuse to participate in the study

Keywords: advanced hiv disease aids acquired immunodeficiency syndrome nutrition in hiv disease people living with hiv plwh
expression of cxcr4 in patients with systemic lupus erythematosus

Conditions: Systemic Lupus Erythematosus

Summary: the objective of this study is to estimate the possible role of cd184 in the pathogenesis of sle; comparing its level among sle cases to healthy controls.

detection of cxcr4 (cd184) expression on cd19+ b cells by flow cytometry in patients of sle, comparing its level in the development of lupus activity and pathogenic process of sle internal organ involvement/ mucocutaneus and/or musculoskeletal involvement. identify this correlation will be useful for clarifying other accessory factors to improve the diagnosis, better treatment strategy, follow up as well as prognosis for these patients

Eligibility criteria:
inclusion criteria: * confirmed sle patients diagnosed and fulfilled the sle classification criteria according to the 2019 acr/eular classification criteria for sle (aringer et al., 2019) * willing and agreed to be included in the study. exclusion criteria: * childhood sle. * sle-patients will refuse to consent to this study. * other autoimmune diseases. * known or suspected malignancies, especially b cell lymphoma.

Keywords: cxcr4,cd184,flow cytometry ,systemic lupus erythematosus
comparison of local anesthetic infusion pump versus depofoam bupivacaine for pain management

Conditions: Pain, Postoperative

Summary: effective post surgical pain control in patients undergoing unilateral deep inferior epigastric perforator (diep) free flap reconstruction.

critical to patient recovery, and can contribute to faster patient mobilization, shorter hospital stays and reduced health care costs. the administration of local anesthetics via wound infiltration is standard of care and an effective practice for post surgical pain management, however this method only provides relatively brief analgesia, usually lasting only 12 hours. other fda approved delivery systems using an indwelling fusion pump catheter (on-q pump) are currently being used in our practice and may be used to extend the duration of action of locally administered analgesia by continuously infusing anesthetic into the wound. alternatively, a depot form of bupivacaine has been fda approved and currently used to deliver a single dose administered via wound infiltration for prolonged analgesia by allowing for the diffusion of the drug over an extended period of time. both of these products are used as a standard practice during diep free flap reconstructions. however, no studies compare the efficacy of these two methods patients undergong unilateral diep flap reconstructions has been done in a prospective, randomized control manner.

Eligibility criteria:
inclusion criteria: * non pregnant women * age 18 years or older * scheduled to have unilateral diep flap breast reconstruction. * must have asa physical status classification of 1,2, or 3 exclusion criteria: * concurrent or recent medical condition that could interfere with study participation * history of any of the following: * hepatitis * alcohol/substance abuse * uncontrolled psychiatric disorders * known allergy/ contraindication to any of the following: * amide-type local anesthetics * opioids * propofol * body weight of less than 50 kg * have participated in another study involving an investigational medication with in the past 30 days * taking analgesics, antidepressants, or glucocorticoids within the 3 days before surgery

Keywords: local anesthetic continuous infusion pump local injection of exparel
parsaclisib in patients with relapsed or refractory follicular lymphoma

Conditions: Follicular Lymphoma

Summary: a phase ib/iii, multicenter, double-blinded study of parsaclisib, a pi3kδ inhibitor, in patients with relapsed or refractory follicular lymphoma


Eligibility criteria:
inclusion criteria: 1. age ≥18 years old. 2. histopathological diagnosis as fl grade1, 2 or 3a 3. the patient is not suitable or refuse the hematopoietic stem cell transplantation(hsct). 4. presence of radiographically measurable lymph nodes or extranodal lesions, defined as at least one lesion longest diameter (ld) measurements \> 1.5 cm and longest vertical diameter (lpd) measurements ≥1.0 cm. 5. life expectancy ≥12 weeks. exclusion criteria: 1. known histological transformation of diffuse large b-cell lymphoma (dlbcl) from indolent non-hodgkin lymphoma (inhl). 2. a history of central nervous system lymphoma (primary or metastatic) and leptomeninges dease. 3. previously received idelalisib, other selective pi3kδ inhibitors or generic pi3k inhibitor treatment. 4. previously received bruton tyrosine kinase inhibitors (e.g., ibrutinib). 5. pregnant or lactating women.
interscalene vs infraspinatus-teres minor (itm) interfascial block in shoulder surgery

Conditions: Shoulder Pain; Pain, Postoperative; Surgical Procedure, Unspecified

Summary: postoperative pain is important following arthroscopic shoulder surgery. postoperative effective pain treatment provides early mobilization and shorter hospital stay.ultrasound (us)-guided brachial plexus blocks such as interscalen and supraclavicular block are usually performed. interscalene brachial plexus block is one of the most preferred techniques among these. due to the phrenic nerve paralysis frequently seen in interscalene block, alternative diaphragm-sparing block techniques have emerged over time. one of these is the infraspinatus teres minor interfascial block. infraspinatus teres minor interfascial block can block both the suprascapular nerve and the axillary nerve, which are effective in the innervation of the shoulder, with a single-point injection. the main aim of our study was to show that there is no difference between interscalene block and infraspinatus-teres-minor interfascial block in terms of their effects on postoperative analgesia in patients undergoing arthroscopic shoulder surgery.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) classification i-ii-iii * scheduled for arthroscopic shoulder surgery under general anesthesia exclusion criteria: * history of bleeding diathesis * receiving anticoagulant treatment * infection of the skin at the site of the needle puncture * pregnancy or lactation * patients who do not accept the procedure * allergy to local anesthetics * chronic pain syndromes requiring opioid intake

Keywords: arthroscopic shoulder surgery postoperative pain interscalene brachial plexus block infraspinatus-teres minor interfascial block
injury occurrence in hip-hop dance

Conditions: Sports Injury; Body Composition

Summary: the study will investigate the effect of structural training program and body composition on injury occurrence in hip-hop dance. assuming that training program can significantly lower the number of injuries (experimental group will have less injuries during and at the end of the trial) and that body fat percentage negatively effects injury occurrence (dancers with higher body fat percentage will be more often injured).


Eligibility criteria:
inclusion criteria: * hip-hop dancer (active) exclusion criteria: * injured

Keywords: hip-hop dance, injuries, body fat
effect of kinesio taping on muscle strength in lower trapezius

Conditions: Shoulder Pain; Muscle Weakness

Summary: the purpose of this project is to investigate the effect of kinesio tape on muscle strength of the lower trapezius in people with shoulder symptoms and decreased muscle strength in the lower trapezius - a randomized controlled trial.

the aim of the study is to investigate the effect of recoil tape with 0-30% tension, by using one application of kinesio tape over the muscle fibers of the lower trapezius from its origin to its insertion. the participants will be divided into intervention group (taping) and control group (no intervention). muscle strength test will be performed before and immediately after taping (20-30 minutes) for both groups using hand-held dynamometer measurements (microfet 3). work is based on the following hypothesis: "kinesio taping using recoil taping provides increased isometric muscle strength in lower trapezius immediately after application".

Eligibility criteria:
inclusion criteria: * shoulder problems * low muscle strength in lower trapezius * positive manual recoil-test for the lower trapezius exclusion criteria: * shoulder surgery \<3 month * pathology in the shoulder related to tumors, fractures, neurology, rupture of tendons

Keywords: lower trapezius kinesio taping
comparison of robotic arm-assisted pet/ct-guided lung biopsy with pet fused ct- fluoroscopy-guided lung biopsy

Conditions: Lung Cancer; Lung Diseases; Adenocarcinoma of Lung

Summary: patients with suspicious lung lesions were undertaken for pet/ct directed under ct fluoroscopy lung biopsy or robotic-assisted biopsy. the biopsy planning including patient positioning was done after f18-fdg pet/ct whole body or regional imaging of the patient. written consent was obtained and the patient will be prepared for the biopsy. lung biopsies were done using a semi-automatic biopsy gun under the imaging guidance (pet fused ct fluoroscopy) following aseptic precautions. follow-up ct scans were taken post-biopsy. the time consumed for the procedure, radiation exposure to the interventionist, complications and diagnostic yield in both the arms were compared.

patients with clinical suspicion of lung lesions were recruited for fdg pet/ct. based on the pet/ct findings and clinical details a pet/ct guided biopsy was planned. the patients were assigned to the two arms. in the first arm, participants underwent a robotic-assisted biopsy. in the second arm, participants underwent pet/ct-directed ct fluoroscopy-guided lung biopsy. the biopsy planning including patient positioning was done after f18-fdg pet/ct whole body or regional imaging of the patient. written consent was obtained and the patient will be prepared for the biopsy. lung biopsies were done using a semi-automatic biopsy gun under the imaging guidance (pet fused ct fluoroscopy) following aseptic precautions. follow-up ct scans were taken post-biopsy. the time consumed for the procedure, radiation exposure to the interventionist, complications and diagnostic yield in both the arms were compared.

Eligibility criteria:
inclusion criteria: 1. age \>/= 18 years 2. fdg avid amenable lung lesion 3. inr \ 80,000/mm3 exclusion criteria: 1. participants with pre-existing bleeding diathesis like hemophilia, coagulopathy defined by inr ≥ 1.2 and platelet counts ≤ 80,000/mm3 2. participants who refuse to provide the written informed consent 3. signs of hypoperfusion like cyanosis, hypotension etc. 4. presence of hypoxemia (spo2 \< 95% -measured in a pulse oximeter) 5. pregnant/lactating females participants 6. non-cooperative participants 7. inaccessible lesions (based on the decision made on pre-biopsy planning) 8. covid-19 positive participants
define predictors for posttransplant diabetes mellitus study

Conditions: Post-transplant Diabetes Mellitus; Kidney Transplant; Complications

Summary: the primary aim of this prospective, multicentre study is to develop an accurate and convenient tool to predict the risk of ptdm at 3 months post-transplant, based on information on the day of transplantation (day 0). in order to create such model, we will start by identifying individual predictor variables at the day of transplantation and subsequently explore the optimal combination of these predictors in multivariable models. secondary objectives include: * compare the performance of the model based on predictor variables at day 0 with existing models for prediction of ptdm (chakkera, san antonio diabetes prediction model and framingham offspring study diabetes mellitus algorithm) * explore the glucose level evolution during the first 2 weeks after transplantation using continuous glucose monitoring, and its relationship with baseline patient characteristics and immunosuppressant drug use. * evaluate the added value of incorporating information on glucose levels in the first and second weeks post-transplant to improve the ptdm prediction model. * identify predictors for early post-transplant hyperglycemia (first 2 weeks post-transplantation) * explore the correlation between early post-transplant hyperglycemia (fasting glycemia, pre-dinner glycemia) and ptdm at 3 months


Eligibility criteria:
inclusion criteria: * adult patients (≥18 years) with end stage kidney disease undergoing kidney transplantation with a deceased or living donor * signed informed consent * initial therapy with at least tacrolimus and corticosteroids exclusion criteria: * patients with a diagnosis of diabetes mellitus (either type 1 or type 2) prior to kidney transplantation * treatment with glp1-ra for weight losing purposes * patients receiving a multi-organ transplantation * abo incompatibility
to reverse endocrine resistance trial - pd 0332991 monotherapy vs pd 0332991 in combination with the endocrine therapy

Conditions: Breast Cancer

Summary: this study aims to assess the activity of pd0332991 in monotherapy and in combination with the endocrine therapy (anastrozole, letrozole, exemestane or fulvestrant) on which the patient has progressed in the previous line for advanced breast cancer in order to reverse endocrine resistance.

in a clinical context, there is a lack of molecular compounds with demonstrated clinical activity in delaying/reversing resistance to endocrine agents. cdk 4/6 inhibitors may represent a biologically-driven option in this context. with the present study investigators aim to complement the ongoing trial on pd0332991 by acquiring information on its clinical activity in post-menopausal patients with er positive, her2 negative advanced breast cancer patients already pretreated with a first-line or second line endocrine therapy.

Eligibility criteria:
inclusion criteria: * histologically proven diagnosis of adenocarcinoma of the breast with evidence of metastatic disease * er positive tumor ≥ 10% * her2 negative breast cancer by fish or ihc * progression of advanced breast cancer on first or second line endocrine therapy for advanced breast cancer * paraffin-embedded tumor available for centralized assessment of biomarkers * measurable disease according to recist 1.1 (bone only disease is allowed only if measurable). * postmenopausal status * eastern cooperative oncology group (ecog) performance status 0 -2 * resolution of all acute toxic effects of prior therapy or surgical procedures to ctcae grade \>1 * adequate organ function exclusion criteria: * unstable brain metastases * prior treatment with more than one line of ct or more than two lines of ht advanced breast cancer or any cdk inhibitor * current treatment with therapeutic doses of anticoagulant * current use or anticipated need for food or drugs that are known strong cyp3a4 inhibitors / inducers, drugs that are predominantly metabolized by cyp3a with narrow therapeutic indices, drugs with the potential of prolonging qt interval * diagnosis of any secondary malignancy within the last 3 years * active inflammatory bowel disease or chronic diarrhea * known human immunodeficiency virus infection; active hepatitis c, active hepatitis b

Keywords: advanced breast cancer postmenopausal er positive her2 negative