Kornimate/medical-research-clean huggingface dataset:
the effectiveness of music on pain and anxiety in iud insertion

Conditions: IUD Insertion Complication; Pain, Acute; Anxiety Acute

Summary: although intrauterine devices (iuds) are a highly effective contraceptive method, fear of pain during insertion is one barrier to use. a review of literature reveals little investigation of interventions for anxiety management during the procedure. furthermore, evidence of non-pharmacological interventions for both anxiety and pain management is limited. music has been shown to be effective at reducing anxiety and pain in a variety of contexts, however to the investigators' knowledge, its effectiveness for anxiety and pain relief during the iud insertion procedure has not been formally examined. this study will therefore examine the effectiveness of listening to music on anxiety and pain during iud insertion.

the study is a randomized controlled trial of patients at least 16 years of age undergoing an iud insertion. the experimental group will receive music, self-selected, with a music-playing device prior and during the procedure and the control group will receive standard care. data for pain and anxiety will be collected prior to the procedure, and during, and after iud insertion. in addition, a post-procedure questionnaire will be given to patients and providers to ask about satisfaction and acceptability of the intervention.

Eligibility criteria:
inclusion criteria: * sufficient understanding of english to complete questionnaires * women who will attend the clinic for an iud insertion and accept to participate in the study exclusion criteria: * women with chronic pain

Keywords: intrauterine device iud anxiety pain music contraception visual analog scale vas
shanghai community prediabetes standardized management project

Conditions: PreDiabetes

Summary: participants with prediabetes is the key targets for diabetes prevention. so, in order to further strengthen and standardize the management of participants with prediabetes in the communities, the investigators start this project of standardized management of participants with prediabetes in communities of shanghai. explore the standardized management model for prediabetes participants within primary healthcare settings in shanghai, to reduce the risk factors of diabetes, improve the blood glucose control, and the quality of life of participants with prediabetes.

participants with prediabetes is the key targets for diabetes prevention. so, in order to further strengthen and standardize the management of participants with prediabetes in the communities, the investigators start this project of standardized management of participants with prediabetes in communities of shanghai. explore the standardized management model for prediabetes participants within primary healthcare settings in shanghai, to reduce the risk factors of diabetes, improve the blood glucose control, and the quality of life of participants with prediabetes. through the collaboration the shanghai municipal center for disease control \& prevention network, this investigators will implement prediabetes screening and lifestyle intervention in around 50 community health service centers in shanghai. life-style interventions including exercise and diet, and diabetes prevention knowledge will be integrated into "train-the-trainers" workshops. trainings will be provided to community health service staff and peer supporters or social workers.

Eligibility criteria:
inclusion criteria: * chinese residents * adult age ≥ 18 years old, 35-75 years old preferred * participants receiving prediabetes management of the basic public health services package in community health centers * bmi≥24 kg/m2 or central obesity (waist circumference≥90 cm in males，waist circumference≥85 cm in females) or hypertension (sbp≥140 mmhg and/or dbp≥90 mmhg) preferred * signed informed consents and willing to participate exclusion criteria: * with serious chronic diseases, tumors, acute and chronic infectious diseases, limb movement disorders, and any mental illnesses * women during pregnancy or breastfeeding * with excessive drinking or illicit drug use * unwilling to participate in the project * histories of severe cardiovascular events (myocardial infarction, stroke, acute coronary syndrome, or transient ischemic attack (tia))

Keywords: prediabetes life style intervention peer support self management support primary healthcare community
overview: use of respiratory support at home in children

Conditions: Sleep Apnea Syndromes in Children; Obesity in Children; Bronchopulmonary Dysplasia (BPD); Neuromuscular Disease; Storage Disease; Malformation; Alveolar Hypoventilation

Summary: the primary outcome is to describe the perceived success of the use of the respiratory support from the parent's point of view

the use of ventilatory support, including cpap (continuous positive airway pressure), which is a mode of ventilation with continuous positive pressure, and bipap (bilevel positive airway pressure), which is a mode of ventilation with two levels of pressure, has seen a significant increase in indications in recent years. the indications have become more numerous and increasingly complex. sleep-related respiratory disorders, including obstructive sleep apnea-hypopnea syndrome, central apnea syndrome, and alveolar hypoventilation, are the primary reasons for these indications. in pediatrics, numerous conditions contribute to sleep-related respiratory disorders: ent malformations, genetic conditions, obesity, bronchopulmonary dysplasia, neuromuscular diseases, thoracic deformities, and storage diseases. the non-use or insufficient use of ventilatory support leads to a lack of treatment for sleep-related respiratory disorders. in the absence of treatment, the consequences are neurocognitive, cardiovascular, and metabolic, resulting in high morbidity. non-use or insufficient use is a cause of failure of ventilatory support. neither the use nor the failure of ventilatory support is clearly defined. it is crucial to evaluate the use of ventilatory support in order to correct factors related to non-use or insufficient use and to prevent the negative consequences resulting from unaddressed sleep-related respiratory disorders. this pilot study aims to assess the use of ventilatory support at home in pediatrics through interviews with patients and their parents. we will use a questionnaire designed for the study, consisting of 10 questions regarding sleep, symptoms, quality of life, technical issues, side effects, economic barriers, and adherence, to describe their experiences with ventilatory support.

Eligibility criteria:
inclusion criteria: * children with respiratory support at home * age 0 to 18 (not yet passed) years old exclusion criteria: * palliative care * invasive ventilation * high flow oxygen therapy

Keywords: respiratory suport sleep apnea syndrome cpap bipap ventilation alveolar hypoventilation non invasive ventilation
icp-332 in subjects with moderate to severe atopic dermatitis

Conditions: Atopic Dermatitis

Summary: a randomized, double-blind, placebo-controlled phase iii study evaluating the efficacy and safety of oral icp-332 in subjects with moderate to severe atopic dermatitis


Eligibility criteria:
inclusion criteria: 1. male or female subjects between 18 and 75 years of age. 2. clinical diagnosis of chronic atopic dermatitis (also known as atopic eczema) for at least 1 year 3. documented recent history of inadequate response to tcs or tci, or for whom topical treatments are otherwise medically inadvisable. 4. subjects must meet the following criteria for disease activity: * eczema area and severity index (easi) score ≥ 16 ; * (body surface area )bsa affected by ad ≥ 10% ; * (validated investigator's global assessment-ad)viga-ad score ≥3 ; * baseline weekly average of daily worst pruritus nrs ≥ 4. 5. women of childbearing potential (wocbp) and men must agree 5. women of childbearing potential (wocbp) and men must agree to contraception. 6. willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures. exclusion criteria: 1. lack of response or inadequate response to prior treatment with any jak inhibitor for ad. 2. other active skin diseases or skin infections requiring systemic treatment or would interfere with appropriate assessment of atopic dermatitis lesions. 3. pregnant or breastfeeding females. 4. history of any clinically major diseases, with the exception of atopic dermatitis. 5. consideration by the investigator, for any reason, that the subject is an unsuitable candidate to receive icp-332 or participate in this study.
can the perception of a treatment influence pain processing - an examination of psychological and neurobiological mechanisms

Conditions: Neuropathic Pain

Summary: the study investigates the effect of an open (in full view of the patient) vs hidden treatment (without the patient's knowledge).


Eligibility criteria:
inclusion criteria: - neuropathic pain \> 3 on a 0-10 nrs. exclusion criteria: * psychiatric or competing neurological disorders. * known allergies to any medications, including local anesthetics.

Keywords: chronic neuropathic pain
tackling postnatal depression: culturally adapted learning through play plus (ltp+) intervention for british mothers of african and caribbean origin

Conditions: Postnatal Depression

Summary: by 2030, depression will be the leading global disease burden. postnatal depression due to childbirth/parenting leads to long-term negative consequences for mothers, their children and their families. the british african/caribbean communities are worse hit by the unprecedented impact of post-covid-19-syndromes, leading to an exponential increase in postnatal depression. yet, the uptake of mental healthcare by british mothers of african and caribbean origin is low due to limited access to culturally appropriate care. theories of attachment and cognitivism were innovatively integrated to examine learning-through-play plus (ltp+) intervention for postnatal depression using a pilot randomised controlled trial. the proposed ltp+ is co-developed and ecologically friendly because it is manualised and can be delivered by non-mental health specialists such as trained community health workers who are more culturally knowledgeable. findings will be disseminated through academic publications/presentations, policy briefs, original animated videos and podcast series laying the foundations for a psychosocial approach to tackling postnatal depression


Eligibility criteria:
inclusion criteria only british mothers of african and caribbean heritage: * experiencing emotional distress due to childbirth or parenting and scored 5 or above on the patient health questionnaire (phq-9) * who have children age 0-3 years * residents of designated communities and available for follow-up * are 18 years and above * able to give informed consent. exclusion criteria are mothers: * with a medical condition that would prevent their participation such as active suicidal ideation, tuberculosis, or heart failure * temporary residents are unlikely to be available for follow up * who are less than 18 years * unable to provide consent. * with non-british african and caribbean heritage.
validation of a personal breath analyzer for diet and energy expenditure assessment and management

Conditions: Obesity

Summary: the purpose of the research is to determine energy expenditure rates and diet and/ physical activity metabolic features of an individual using current state technologies and a new technology created at the center for bioelectronics and biosensors at asu. this is a pilot study which intent is to validate this device for use in the weight loss patient population. this study will involve research of metabolic physiological parameters that are measured through the breath of the individuals, together with other physical parameters (weight, height, date of birth, fat and lean body composition via bio-impedance, heart rate, blood pressure, and breathing rate) assessed in the clinic, and a questionnaire about diary physical activities. the study will involve withdrawn of breath samples at resting conditions, and under diets or physical activities regimes. this instrument will assist our patients in terms of tailoring their diet/nutrition through their weight loss journey prior and after surgery. as a new technology, it will be an excellent tool for compliance assessment and engagement with the weight loss program as well as for long term follow up.

the breezing® device is a new technology locally invented in the state of arizona that uses a sensor cartridge and a flow meter to determine the rate of consumed oxygen and produced carbon dioxide in the breath. the sensing technology of the new indirect calorimeter, which used a cell-phone camera as the optical detector. the current breezing® device uses a code to carry calibration parameters of a single-use sensor cartridge, which can be scanned and recognized by the mobile application (app). the device is 6.0 oz. (170 g), and 1.8 in × 2.1 in × 4.8 in (4.7 cm × 5.4 cm × 12.3 cm), and connects wirelessly to an ios mobile device, using bluetooth 4.0 technology. the mobile device (phone or tablet) receives data from the device, processes information, and then provides test results and summaries through a graphic user interface. it determines the energy expenditure from the measurement of vo2 and vco2 according to the weir equation, along with rq. in addition to the sensor cartridge, the breezing® device is used with a non-rebreathing 2-valvesmouthpiece. this new device will provide a more precise information regarding metabolic rate in our bariatric patients to better tailor their preoperative diet and monitor their weight loss. up to date, this device was never used or validated before in the bariatric population under this setting.

Eligibility criteria:
inclusion criteria: * females or males between 18 and 50 yo * class ii and class iii obesity (bmi 35 and above) exclusion criteria: - no obesity. patients with normal bmi
revitalization of damaged skin due to chronic skin diseases

Conditions: Chronic Eczema; Psoriasis; Atopic Dermatitis

Summary: chronic skin disease lead to skin damage and disfiguring to the patient skin. sometimes, achieving normal skin is not possible by the normal traditional treatment, this study is focusing on use of ace csd formula which is mixture of natural peptides and herbs. the main aim is to restore the normal skin appearance for the patient and control the episodes of flare.

psoriasis is a chronic, immune mediated (type 2 and type 17) chronic skin disease. the production of the immune proteins that leads to continuous inflammatory mediated process. the result of chronic inflammation is they hyper keratotic layer of skin which gets attacks of atopic dermatitis leading to symptoms of itching, pruritis and in situ bleeding. ace csd, with the multiple factors that mediates the immune response and control the protein receptors, in addition to the multiple regeneration peptides that are specifically extracted from healthy skin of newly born sheep; in addition to multiple chinese herbs that contains different anabolic factors was tested to be able to regenerate the damaged skin and locally modulate the immunity reactions so the skin can regenerate fully to replace the damaged skin with normal healthy skin.

Eligibility criteria:
inclusion criteria: * chronic skin condition lasts for more than 1 year. * tried traditional treatment with limited or without effect. * not on steroids for at least 6 weeks. exclusion criteria: * patients on steroid. * patients intolerable to protein or allergic to proteins * during pregnancy or lactation

Keywords: chronic skin disease psoriasis eczema atopic dermatitis
a study to determine the safety and efficacy of imatinib mesylate in patients with idiopathic hypereosinophilic syndrome

Conditions: Hypereosinophilic Syndrome

Summary: the objectives of the study are: 1. evaluation of the safety profile of imatinib mesylate in patients with idiopathic hypereosinophilic syndrome resistant or refractory to, or intolerant of, prednisone, hydroxyurea or interferon-alpha, or untreated patients carrying the fip1l1-pdgfra fusion protein. 2. evaluation of the efficacy of imatinib mesylate in patients with idiopathic hypereosinophilic syndrome 3. analysis of patient's blood samples for the detection of activated kinases.


Eligibility criteria:
inclusion criteria: idiopathic hypereosinophilic syndromes are included provided they belong to one of the following categories: 1. previously treated and showing documented resistance or refractoriness to, or intolerance of, prednisone, hydroxyurea or interferon-alpha. 2. not previously treated but with documented fip1l1-pdgfra fusion protein exclusion criteria: * other diseases associated with hypereosinophilia * serum creatinine, serum bilirubin, ast, alt more than twice the upper normal limit. * ecog performance status \>3 other protocol-defined exclusion criteria may apply.

Keywords: hypereosinophilic syndrome imatinib
the grief navigation trial: a comparison of two interventions to support parents after their child's unexpected or traumatic death

Conditions: Bereavement

Summary: parents of children who die traumatically or unexpectedly from things like suicide or an overdose suffer from mental and physical health problems and can experience massive disruptions in their family life. for about half of these parents, the first, and sometimes only, interactions they have with the healthcare system when their child dies are with a medical examiner or coroner (hereafter 'me'). but mes have little to no training in helping grieving families, and there are no standards guiding medical examiners or coroners on how or even if they should help grieving families. this gap leaves parents to find the help they need on their own. this research will test two different strategies for addressing this gap in the healthcare system.

of approximately 60,000 annual deaths of people \< 25 years old, \~45% occur unexpectedly or traumatically (e.g., from homicide, suicide, or unintentional injury) and become a medical examiner or coroner (hereafter 'me') case. parents and caregivers (hereafter 'parents') of these children suffer debilitating mental health issues like complicated grief and depression, physical problems and family dysfunction, and struggle to find support. often, the me is parents' sole point of contact with the healthcare system. yet mes have limited education, guidance, and tools to support bereaved parents. scalable systems-level interventions are needed, at the point of me care, to connect bereaved parents to critical supports. this study will compare two interventions to facilitate care across healthcare settings for bereaved parents: 1. communityrx-bereavement (crx-b), an evidence- and theory-based, low intensity, highly scalable intervention, and 2. general bereavement support information (gbsi), a standardized treatment regimen developed from extant literature and current recommended standards for supporting parents after a child's death. this is a pragmatic, multi-site 1:1 randomized controlled comparative effectiveness study using a type i hybrid design. crx-b and gbsi will be carried out by missing pieces, a community-based organization. to learn about which strategy works better, the study team will ask parents to complete surveys \~6.5 months after their child dies.

Eligibility criteria:
inclusion criteria: * parents or caregivers of me cases involving a person \< 25 years old from one of the following offices: cook county medical examiners, lake county coroners, dupage county coroner, will county coroner, mchenry county coroner, kane county coroner, peoria county coroner * parents or caregivers who provide permission to the me to be referred to missing pieces * parent or caregivers who are referred to missing pieces by a me * parents or caregivers able to read and communicate in english or spanish exclusion criteria: * parents or caregivers unable to read or communicate in english or spanish * parents or caregivers under the age of 18 years old

Keywords: grief caregivers community resources pediatric self-efficacy coroners and medical examiners
assess the performance of metagenomic sequencing in the diagnosis of sti (ngs-ist)

Conditions: Sexually Transmitted Infections (Not HIV or Hepatitis); Chlamydia Trachomatis Infection; Neisseria Gonorrhoeae Infection; Mycoplasma Genitalium Infection

Summary: the main objective of the study will be to assess the performance of the next-generation-sequencing (ngs) diagnostics of chlamydia trachomatis and neisseria gonorrhoeae compared to reference techniques.

sexually transmitted infections (stis) have become a major global public health problem and are among the most common infections. the increase antibiotic resistance, particularly in neisseria gonorrhoeae and mycoplasma genitalium, is of concern. currently, the diagnosis of stis is based on specific tests by pathogen, mainly by standard culture allowing an antibiotic susceptibility testing, gene amplification tests possibly allowing the search for resistance genes and serologies. next-generation-sequencing (ngs) is based on the detection and analysis of any dna and rna present in the studied sample with a high degree of sensitivity, this method enables the precise identification of non-human sequences regardless its bacterial, viral or parasitologic origin, to detect resistance genes and to characterize the strains. the investigators propose to assess the performance of ngs for the diagnosis of stis. a cohort of 332 prep users from saint-antoine and tenon hospitals will be followed for this purpose every 3 months during 1 year (including also the intermediate visits if needed in case of stis symptoms). the main objective of the study will be to assess the performance of the ngs diagnostics of chlamydia trachomatis and neisseria gonorrhoeae compared to reference techniques. the secondary objectives will be (i) to evaluate the performance of the diagnosis by ngs of the other stis compared to the reference techniques, (ii) to evaluate the interest and the sensitivity of a 3 sites pooled sample "urine, throat and rectum" and the swab sampling from the ulcer lesions in the case of the ulcerations presence for the diagnosis of stis, (iii) to describe the natural history of colonization with mycoplasma genitalium and the appearance of resistance or pressure of antibiotic selection and (iv) to evaluate the prevalence of agents not usually sought in screening for sti (hsv-1, hsv-2, haemophilus ducreyi, campylobacter sp, shigella sp, clostridioides difficile, entamoeba histolytica). improved diagnosis of stis and resistance will allow a better patient management.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * msm * prep users * acceptance of study constraints * with or without social security scheme or state medical aid * signature of consent form to participate in the study exclusion criteria: * language barrier making questioning impossible.

Keywords: metagenomics next-generation-sequencing (ngs) sexually transmitted infections (sti) pre-exposure prophylaxis (prep) men who have sex with men (msm)