Kornimate/medical-research-clean huggingface dataset:
cases with traumatic and non traumatic brain damage treated in the intensive care

Conditions: Brain Injuries

Summary: cases of traumatic and nontraumatic brain damage have high rates of morbidity and mortality. in this study of cases being treated in the icu for a diagnosis of brain damage, it was aimed to evaluate the relationship between mortality and the distribution of reason for and resulting type of brain damage and to determine other factors affecting mortality.

after local ethics committee approval, a total of 1004 patients treated in the icu in a 2-year period were retrospectively reviewed. 135 patients, determined with traumatic or nontraumatic brain damage, with a more than 24-hour stay in the icu, included the study. reasons for brain damage were determined as brain damage associated with pure head trauma (group ht), head trauma accompanying general body trauma (group ht+gbt) and spontaneous haemorrhage (group sh). the type of brain damage was defined from the radiological diagnosis as subarachnoid haemorrhage, intracranial haemorrhage (ich), subdural haematoma(sdh), epidural haematoma(edh), skull fracture, brain contusion or a combination of these (com).

Eligibility criteria:
inclusion criteria: * patients treated in the icu with the diagnose of traumatic or nontraumatic brain damage, with a more than 24-hour stay. exclusion criteria: * patients admitted less than 24 hour.

Keywords: traumatic brain injury brain damage mortality c10.228.140.199
effect of case management following discharge from methadone treatment

Conditions: Opioid-Related Disorders

Summary: the purpose of this project is to assess whether enhanced outreach counseling (eoc) is an effective outreach strategy for discharged methadone maintenance patients compared to a standard referral procedure. eoc is a brief (30 minute) face-to-face intervention, followed by six weeks of ongoing telephone counseling/case management designed to help eligible out-of-treatment methadone patients re-enter treatment. several studies have shown those patients who voluntarily re-enter treatment improve significantly following re-enrollment.


Eligibility criteria:
patients who have been discharged from methadone maintenance treatment at the pvamc who consented (as active patients) to be contacted for follow-up upon discharge.
effect of vitamin d supplementation on muscle mass and function

Conditions: Obesity; Insulin Resistance; Inflammation

Summary: the study was designed to assess the effects of vitamin d supplementation during exercise training on body composition, muscle function, and glucose tolerance. the investigators hypothesis for these studies is that vitamin d supplementation enhances exercise-induced increases in strength and lean mass, potentially through enhancing insulin sensitivity and reducing inflammation.

the study was designed to assess the effects of vitamin d supplementation during exercise training on body composition, muscle function, and glucose tolerance. it was a double-blind, randomized, placebo-controlled, clinical trial with participants randomized into either a 4,000 iu/day vitamin d or placebo group and all participants completed 12 wks (3 d/wk) of exercise training.

Eligibility criteria:
inclusion criteria: * physical activity scores in the "low" to "very low" category * fitness estimations in the "below average" or lower categories * body mass index scores \>24.9 indicating overweight or obesity. exclusion criteria: * use of tanning booths or other artificial uv light exposure * high baseline vitamin d and calcium intake * plans to visit sunny/warm destinations during the winter months/study period * history or presence of metabolic disease, type 2 diabetes, eating disorders, gastrointestinal disorders, pregnancy or lactation * use of drugs to treat obesity (last 12 weeks) * use of over the counter anti-obesity agents (last 12 weeks) * recent initiation of an exercise program (last four weeks).

Keywords: 25-hydroxyvitamin d parathyroid hormone lean mass muscular strength glucose tolerance
an individualized physical activity program in patients over 65 years with hematologic malignancies

Conditions: Aged; Aged, 80 and Over; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Exercise; Quality of Life; Fatigue

Summary: older people with cancer differ from younger patients due to the combined effects of aging, comorbidities and cancer treatments on their health. in acute myeloid leukemia (aml) and non-hodgkin lymphoma (nhl), chemotherapy, which is the main treatment, is associated with significant toxicity that negatively affects patients' physical capacities and quality of life, already declining with age and comorbidities. it therefore seems essential to develop and evaluate interventions that can prevent physical and psychosocial decline and its consequences in these populations. however, no studies have evaluated a physical activity (pa) program among these populations, although the absence of risk of implementing pa during intense therapeutic procedures has been confirmed. ocapi is an interdisciplinary, prospective, interventional, feasibility study. it is intended to include 20 aml and 20 nhl patients 65 years of age or older at the time of initiation of the first chemotherapy line, with an ecog \<3, with no contraindications to pa and no history or coexistence of other primary cancer. expected results are to demonstrate that a program offering supervised sessions in a sterile room or at home and remote support can enable patients with aml or nhl to perform their daily pa in autonomy. all these results will generate preliminary data before implementing a larger national study.


Eligibility criteria:
inclusion criteria: * age 65 and over, * with histologically confirmed non-hodgkin's lymphoma (nhl) or acute myeloid leukemia (aml), * requiring a first line of chemotherapy treatment or azacitidine - vénétoclax combination, * followed-up in one of the investigating centers, * residing in one of the following departments: ain, ardèche, drôme, isère, loire, rhône, savoie, haute-savoie, * having a ecog \< 3, * with a life expectancy \> 6 months, * whose ability to engage in physical activity has been certified by a medical certificate issued by the investigator physician, * available and willing to participate in the study for the duration of the intervention and follow-up, * able to understand, read and write french, * affiliated with a social security scheme, * having dated and signed an informed consent. exclusion criteria: * personal history or co-existence of another primary cancer (except of in situ cancer regardless of the site and/or basal cell skin cancer and/or non-mammary cancer in complete remission for more than 5 years), * treated by immunotherapy alone, * participating in concurrent physical activity studies, * deprived of their liberty by court or administrative decision.
comparing between xp endo finisher and conventional irrigation method on post-operative flare ups in necrotic teeth

Conditions: Dental Pulp Necroses

Summary: comparing the postoperative flare ups and pain after adding the xp endo finisher to the final irrigation protocol on necrotic mandibular premolars.

patients are randomized into 2 groups after meeting the eligibility criteria, 1. each patient will be given pain scale chart in order to record his /her pain level before any intervention. 2. the tooth is anesthetized, accessed and mechanical instrumentation to be made 3 a) for the experimental group: the canals will be thoroughly irrigated using 3ml syringe of 2.5% sodium hypochlorite between every subsequent instrument. xp endo finisher is used after the last instrument in preparation b) for the control group : the canals will be thoroughly irrigated using 3ml syringe of 2.5% sodium hypochlorite between every subsequent instrument. 4) obturation is done and postoperative instructions are given to the patient

Eligibility criteria:
inclusion criteria: i. age between 18-50 years old. ii. males or females. iii. mandibular premolars * asymptomatic. * non-vital response of pulp tissue (negative response). * with or without periapical radiolucency. exclusion criteria: i. patients allergic to penicillin. ii. pregnant females. iii. patients having significant systemic disorder. iv. if antibiotics have been administrated during the past two weeks preoperatively. v. patients having bruxism or clenching. vi. teeth that have : * vital pulp tissues. * association with swelling * acute peri-apical abscess * periodontally affected teeth * no possible restorability * previous endodontic treatment.
unannounced meal handling of advanced closed loop insulin delivery in monitored condition

Conditions: type1diabetes

Summary: the study will follow participants for the periods of 3 months while using an advanced hybrid closed loop algorithm in free living conditions . each period will have a different meal handling protocols. the objective is to identify the mitigation of the algorithm with different meal handling approaches.


Eligibility criteria:
1. subject is 20 to 70 years of age at time of screening 2. subject's weight is between 50 and 120 kg 3. a clinical diagnosis of type 1 diabetes as determined by the investigator for a minimum of 36 months prior to enrollment 4. subject has ongoing use of an insulin pump and rtcgm ≥ 6 months prior to screening 5. subject has an a1c value ≤ 10.0% demonstrated at the time of enrollment. 6. subject uses a rapid-acting analogue insulin in his/her pump 7. patient is willing to undergo all study procedures 8. english proficiency 9. minimum daily insulin requirement (total daily dose) of greater than or equal to 8 units exclusion: 1. female subject who has a positive serum pregnancy screening test, or who plans to become pregnant during the course of the study 2. subject has unresolved adverse skin condition, or unable to tolerate tape adhesive, in the area of sensor placement or device replacement (e.g., psoriasis, rash, staphylococcus infection) 3. subject has a history of hypoglycemic seizure or hypoglycemic coma within the past 12 months 4. subjects currently taking adjunct therapy with sglt2-inhibitors, glp-1 mimetics, amylin. 5. subject has a history of seizure disorder unrelated to diabetes within the past 12 months 6. gastroparesis, uncontrolled thyroid disorder, addison dis. , pituitary insufficiency 7. subject has a history of myocardial infarction, unstable angina, coronary artery bypass surgery, coronary artery stenting, transient ischemic attack (tia), cerebrovascular accident (cva), congestive heart failure, ventricular rhythm disturbances, or thromboembolic disease within the past 6 months 8. subject has a presence of a cardiac pacemaker or any other device that may be sensitive to radio frequency telemetry 9. subject has any condition, including screening lab values that in the opinion of the investigator may preclude him/her from participating in the study and completing study related procedures 10. subject is actively participating in other investigational study (drug or device) 11. subjects who consume alcohol daily
patterns of care in hormone-receptor positive, advanced breast cancer

Conditions: Breast Cancer

Summary: the purpose of this study is to characterize the current patterns of care for patients with hormone-receptor-positive, advanced breast cancer who have failed one prior endocrine therapy in brazil. to investigate patient-related, disease-related and physician-related characteristics that correlate with the use of either endocrine treatment or chemotherapy in such patients. and to evaluate patients' understanding of the treatment options and their participation in the choice.


Eligibility criteria:
inclusion criteria: * histological or cytological diagnosis of breast cancer * postmenopausal status at the time of enrolment, according to the following definitions: * history of bilateral oophorectomy at any age * proven hormonal menopause * positive estrogen receptor (er) and/or progesterone receptor (pr) by immuno * failure of one previous endocrine therapy in the adjuvant or metastatic setting * use of no more than one previous chemotherapy regimen in the neoadjuvant or adjuvant setting * indication to receive chemotherapy or endocrine therapy exclusion criteria: * inability to comply with the study protocol * use of more than one previous endocrine therapy, regardless of the setting; -- previous use of chemotherapy for metastatic disease * use of neoadjuvant endocrine therapy as the only previous type of endocrine therapy * serious medical, surgical or psychiatric comorbidity that, upon investigator's discretion, should preclude participation in the study.

Keywords: breast cancer hormone receptor positive, advanced breast cancer
bioflow-iii all-comers orsiro safety and performance registry

Conditions: Coronary Artery Disease; Myocardial Ischemia

Summary: this registry is a clinical post-market evaluation of the orsiro less in subjects requiring coronary revascularization with drug eluting stents (des).

for the majority of coronary artery disease (cad), treatment with percutaneous transluminal coronary angioplasty (ptca) provides high initial procedural success. however, the medium to long-term complications range from rather immediate elastic recoil or vessel contraction to longer processes like smooth muscle cell proliferation and excessive production of extra cellular matrix, thrombus formation and atherosclerotic changes like restenosis or angiographic re-narrowing. the reported incidence of restenosis after ptca ranges from 30%-50%. such rates of recurrence have serious economic consequences. bare metal stents (bms), designed to address the limitations of ptca, reduced the angiographic and clinical restenosis rates in de novo lesions compared to ptca alone and decreased the need for cabg. bms substantially reduced the incidence of abrupt artery closure, but restenosis still occurred in about 20%-40% of cases, necessitating repeat procedures. the invention of drug eluting stents (des) significantly improved on the principle of bms by adding an antiproliferative drug (directly immobilised on the stent surface or released from a polymer matrix), which inhibits neointimal hyperplasia. the introduction of des greatly reduced the incidence of restenosis and resulted in a better safety profile as compared to bms with systemic drug administration. these advantages and a lower cost compared to surgical interventions has made des an attractive option to treat coronary artery disease. this observational registry is designed to investigate and collect clinical evidence for the clinical performance and safety of the orsiro drug eluting stent system in an all-comers patient population in daily clinical practice.

Eligibility criteria:
inclusion criteria: * symptomatic coronary artery disease * subject has signed informed consent for data release * subject is geographically stable and willing to participate at all follow-up assessments * subject is ≥ 18 years exclusion criteria: * subject did not sign informed consent for data release * pregnancy * known intolerance to aspirin, clopidogrel, ticlopidine, heparin or any other anticoagulation / antiplatelet therapy required for pci, stainless steel, sirolimus or contrast media * planned surgery within 6 months of pci unless dual antiplatelet therapy will be maintained * currently participating in another study and primary endpoint is not reached yet.

Keywords: international multicenter observational registry all-comers open label registry orsiro drug eluting stent (des) stenting treatment of coronary artery disease coronary revascularization percutaneous coronary intervention stemi nstemi ischemia angina subgroups acute myocardial infarction diabetes small vessels chronic total occlusion (cto)
interactions of enteric infections and malnutrition and the consequences for child health and development

Conditions: Diarrhea; Malnutrition; Stunting; Wasting; Immune Response; Cognitive Development

Summary: malnutrition is considered one of the most prevalent risk factors for morbidity and mortality in children under five. an estimated 20% of children in the developing world are malnourished \[1\] and poor nutrition is linked to more than half of all child deaths worldwide \[2\]. malnutrition in early childhood may lead to cognitive and physical deficits and may cause similar deficits in future generations as malnourished mothers give birth to low birth weight children \[3\]. in addition, malnutrition increases susceptibility and incidence of infections and is associated with diminished response to vaccines. the mal-ed project is designed to determine the impact of enteric infections/diarrhea that alter gut function and impair children's nutrition, growth and development to help develop new intervention strategies that can break the vicious enteric infection-malnutrition cycle and reduce its global burden. the overall objective of the mal-ed project is to quantify the associations of specific enteric pathogens, measures of physical and mental development, micronutrient malnutrition, gut function biomarkers, the gut microbiome, and immune responses in very young children in resource-limited settings across eight sites that vary by culture, economics, geography, and climate. the central hypothesis of the mal-ed project is that infection (and co-infection) with specific enteropathogens leads to impaired growth and development and to diminished immune response to orally administered vaccines by causing intestinal inflammation and/or by altering intestinal barrier and absorptive function. data analyses will test for associations between enteropathogen infections and growth/development to help illuminate: * which micro-organisms or mixed infections are most frequently associated with growth faltering and poor development; and * at what age specific infections cause the most disruption to growth and development and impair immune response.


Eligibility criteria:
inclusion criteria: * less than 17 days old. exclusion criteria: * mother is less than 16 years of age. * mother has another child inthe mal-ed study. * pregnancy resulted in multiple birth (e.g., twins). * child has a severe disease requiring hospitalization for something other than for a typical healthy birth. * child has a severe or chronic condition diagnosed by a medical doctor (e.g., neonatal disease, renal disease, chronic heart failure, liver disease, cystic fibrosis, congenital conditions). * child has enteropathies diagnosed by medical doctor. * mother is living and unable to provide informed consent.

Keywords: cognitive development diarrheal disease enteric infections malnutrition vaccine response enteropathy antibiotic use micronutrients breast feeding gut inflammation
exploratory study of zg-801 for the treatment of hyperkalemia

Conditions: Hyperkalemia

Summary: to investigate the efficacy of each zg-801 starting dose and the titration algorithm of zg-801 for the treatment of hyperkalemia in japanese patients. to evaluate the safety of zg-801 for the chronic use (total over 52 weeks). in addition, to confirm the safety after the discontinuation of zg-801 treatment on 1 week follow-up.


Eligibility criteria:
inclusion criteria: * males and females ages 18 - 80 * informed consent given * serum potassium measurement at baseline is 5.1 to \< 6.5 meq/l (non-dialysis patients or 5.5 to \< 6.5 meq/l (dialysis patients) exclusion criteria: * subjects with hospitalization for hyper- or hypoglycemia with type 2 diabetes or for acute exacerbations of heart failure within the previous 3 months * subjects with severe heart failure, defined as nyha (new york heart association) class iv * subjects with uncorrected hemodynamically significant primary vascular disease or uncontrolled or hemodynamically unstable arrhythmia * subjects with coronary artery bypass graft, percutaneous intervention, or major surgery including thoracic and cardiac, within the previous 3 months or anticipated need during study participation * subjects with heart, liver (only dialysis patients), or kidney transplant recipient, or anticipated need for transplant during the study period * subjects with any of the significant cardiovascular or cerebrovascular events within the previous 2 months * subjects with a history of or current diagnosis of a severe swallowing disorder, moderate to severe gastroparesis, or history of bariatric surgery, bowel obstruction or severe gastrointestinal disorders or major gastrointestinal surgery * subjects who cannot use the oral concomitant medication to be separate 3 hours from zg-801 medication * subjects suspected of transient high potassium levels, such as those caused only by dietary effects
immediate effect of hamstring stretching in patients with chronic low back pain

Conditions: Chronic Low-back Pain

Summary: thigh muscles flexibility deficits contribute to handicap in chronic low back pain patients. the study aims to evaluate the immediate effect of thigh muscles stretching in patients with chronic low back pain. the investigation team suppose that flexibility improvement could be detected by instrumented clinical measurements and such difference could be related to psycho-social factors evaluated by questionnaires.

the primary objective of the study is to evaluate the immediate effect of the hamstring muscle stretching in patients presenting chronic low back pain. the secondary objectives are: (1) to evaluate intra- and interrater reliability, construct validity and responsiveness of the hamstring flexibility measurements (active knee extension \[ake\], straight leg rise \[slr\]) realised with digital inclinometer, (2) to evaluate factors that potentially could influence immediate effect of the hamstring stretching, specifically psycho-social factors fear avoidance belief questionnaire (fabq), hospital anxiety and depression scale (had), neuropathic pain presence (dn4).

Eligibility criteria:
inclusion criteria: * age between 18 and 60 years * chronic low back pain (\>3 months) with or without pain irradiation to lower limb * hamstring flexibility deficit (ake \ 5cm) exclusion criteria: * pregnancy or breastfeeding, * condition of restricted mental/legal autonomy (ex. guardianship) , * no social security insurance,

Keywords: chronic low back pain hamstring flexibility hamstring stretching immediate stretching effect