Kornimate/medical-research-clean huggingface dataset:
genotyping of cytomegalovirus from patients in israel

Conditions: Cytomegalovirus Infections

Summary: the researchers select 100 cytomegalovirus (cmv) dna samples from patients diagnosed with cmv infection. patients include bone marrow transplant patients, pregnant women and newborns. the researchers determine viral load by real-time polymerase chain reaction (pcr). they amplify cmv-gb sequences by pcr and type by sequencing and restriction fragment length polymorphism (rflp). the researchers obtain clinical data from patients' records. they examine association between patients' clinical status and cmv-gb genotype and viral load.

the study aims at finding association between cmv viral load and viral glycoprotein b genotype and the clinical status of patients suffering from cmv infection. bone marrow transplant patients are at increased risk of developing severe cmv disease and are routinely followed for viral load. fetuses are also at high risk for developing severe malformations and neurological defects following maternal primary infection during pregnancy. therefore amniotic fluid from women diagnosed with cmv infection is examined for cmv presence. newborns having congenital defects are tested for cmv excretion. there is not yet any confirmed marker for assessment of the potential severity of the viral infection and for prognosis. therefore we shall attempt to find association between the viral load and genotype and the clinical status. cmv dna samples prepared at the central virology laboratory from clinical specimens obtained from patients for diagnostic purposes will be coded and then subjected to viral load analysis using real-time pcr. the gb genotype will be determined by either of two methods described in the literature: (a) pcr and rflp (b) pcr and sequencing. relevant clinical data will be retrieved from the patients clinical records and saved as coded information to match the samples. bone marrow transplant patients will be followed for prolonged periods covering repeated viral reactivation events. clinical records from mothers and newborns will be matched when present. otherwise maternal and newborn samples will be kept as is. statistical analysis will be performed to try and find association between the clinical status of patients, the viral load and the viral genotype.

Eligibility criteria:
inclusion criteria: * cmv dna sample from a transplant patient with cmv disease. * cmv dna from amniotic fluid of women with cmv infection * cmv dna from urine of newborns with congenital defects compatible with cmv.

Keywords: cytomegalovirus cmv pregnancy amniotic fluid bone marrow transplantation viral load glycoprotein b genotyping pcr real-time pcr cmv disease congenital cmv infection
the role of nm/ct 870 dr camera in the diagnosis of joint prosthesis and tibial open reduction and internal fixation (orif) complications.

Conditions: Bone Infection

Summary: this is a prospective study. patients' cohort is composed of 70 consecutive post joint replacement and post tibial orif patients, referred by their orthopedic surgeon to the nuclear medicine institute of tel aviv sourasky medical center in the diagnostic work up of post operative bone infection and or mechanical loosening. the proposed study will be presented to the ethical committee of the medical center and will be started once approved.


Eligibility criteria:
inclusion criteria: 1. three months or more post joint replacement, or post tibial orif, or last surgical intervention adult patients suspected of bone infection and or mechanical loosening. exclusion criteria: 1. patients younger than 18 years; 2. shorter than 3 month surgical intervention at the suspected area; newly diagnosed (\<3 months) fractures around the prosthesis; 3. pathological fractures (e.g. metastatic).
ambulatory blood pressure control and cognition in patients with obstructive sleep apnea (ample)

Conditions: Obstructive Sleep Apnea

Summary: to compare the blood pressure control and cognitive responses of three groups of patients: those diagnosed with obstructive sleep apnea (osa) and treated with continuous positive airway pressure (cpap) for at least six months, those diagnosed with osa but not treated, and those without osa.

this study is designed as an observational, cross-sectional investigation at the national university hospital and alexandra hospital. the research aims to enroll 50 eligible patients in each of the three groups (osa treated, osa untreated, and non-osa, totaling 150 participants). the recruited participants will undergo ambulatory blood pressure monitoring (abpm) and the montreal cognitive assessment (moca). abpm is a widely used, noninvasive method to determine patients' blood pressure control. moca is a widely used screening tool designed to assess cognitive function and detect mild cognitive impairment or early signs of dementia. the moca evaluates various cognitive domains, including attention, memory, language, visuospatial abilities, executive functions, and orientation. it consists of a series of tasks and questions that assess different aspects of cognitive functioning, such as drawing specific shapes, recalling words or numbers, and performing simple calculations. a trained healthcare professional will administer the digital version of the moca, which usually takes less than 30 minutes to complete. the moca has been validated for use in diverse populations and has shown good sensitivity in detecting mild cognitive impairment. the maximum score on the moca is 30. lower scores may indicate potential cognitive impairment.

Eligibility criteria:
inclusion criteria: * known osa (ahi \>/=15 events/ hour, based on sleep study) on cpap treatment for at least six months (n=50) * known osa (ahi \>/=15 events/ hour, based on sleep study) not on cpap treatment (n=50) * known non-osa (ahi \<15 events/ hour, based on sleep study) (n=50) exclusion criteria: * known-osa on non-cpap treatment (e.g., mandibular advancement device, surgery, or hypoglossal nerve stimulation), * heart failure, * atrial fibrillation, or acute coronary syndrome in the prior 3 months * dementia (based on the medical record) * previous stroke * non-english-speaking subjects * pregnant and lactating women

Keywords: obstructive sleep apnea hypertension cognitive impairment
duration of exercise program in interstitial lung diseases.

Conditions: Interstitial Lung Disease

Summary: we aimed to compare the functional results of the 8th week with the results of the 12th week of the exercise programs applied to the patients with ild.

exercise programs (ep) have been shown to be the effective approach for functional outcomes in interstitial lung diseases (ild). in many studies, the duration of exercise programs varies between 8-12 weeks. however, the optimal duration of exercise program is still unknown. we aimed to compare the results of the 8th week with the results of the 12th week of the pr programs applied to the patients with ild. a total of 14 patients with ild referred to our pr unit \[11 idiopathic pulmonary fibrosis, 2 sarcoidosis (stage 3 and 4) and 1 nonspecific interstitial pneumonia\] were included in the study. pulmonary function test, arterial blood gas analysis, 6- minute walk test, mmrc dyspnea scale, quality of life questionnaires and hospital anxiety depression scale were performed before, at the 8th and 12th weeks after the exercise program applied to the patients twice a week.

Eligibility criteria:
inclusion criteria: * completed the 12 week exercise program * diagnosed with ild exclusion criteria: * not completed 12 week exercise program

Keywords: exercise duration
substance abuse treatment to hiv care (sat2hiv): the motivational interviewing-based brief intervention experiment

Conditions: Substance Use

Summary: to test the effectiveness of a single 20-30 minute motivational interviewing-based brief intervention for substance use within hiv/aids settings.

the substance abuse treatment to hiv care (sat2hiv) project, a type 2 effectiveness-implementation hybrid trial, seeks to address this gap in services by providing new knowledge regarding the effectiveness of brief intervention (bi) for substance use within community-based hiv/aids service settings, as well as new knowledge regarding how to address the well-documented underutilization of evidence-based practices in real-world settings. the specific aims of this project are: aim 1: to experimentally test the effectiveness of a motivational interviewing-based bi for substance use within community-based hiv/aids service organizations, relative to usual care (uc). aim 2: to experimentally test the effectiveness of adding an organizational-level implementation intervention called implementation \& sustainment facilitation (isf) to enhance the effectiveness of the implementation strategy currently used by samhsa-funded addiction technology treatment centers (attcs; i.e., online introductory training, 2-day training workshop, ongoing feedback and coaching).

Eligibility criteria:
inclusion criteria: * have hiv/aids. * be 18 years of age or older. * acknowledges use of at least one substance within the past 28 days and endorse 2+ substance use disorder symptoms during the past 12-months. * provide signed and dated assurance of consent. exclusion criteria: * are unable to speak english. * are unwilling to allow brief intervention sessions to be audio recorded. * are unwilling to participate in the study.
outcomes of diabetic macula edema patients switched to aflibercept from bevacizumab and/or ranibizumab

Conditions: Diabetic Macular Edema

Summary: patients with diabetic macular edema who were switched to aflibercept after having been treated with bevacizumab or ranibizumab were retrospectively reviewed to assess for visual acuity and anatomic outcomes.


Eligibility criteria:
inclusion criteria: those patients with diabetic macular edema switched to aflibercept from bevacizumab and/or ranibizumab - exclusion criteria: none -
comparison of early phase infections risk between midline and piccline caheters: midline and piccline catheters

Conditions: Catheter-related Bloodstream Infection

Summary: a long-term venous access is frequently required in patient management. currently, it is ensured by using the long peripheral intravenous catheters (midline) or peripheral inserted central catheters (picc line). either is inserted into a peripheral vein of the upper arm and extends to the distal axillary vein. if the indications for the two catheters can sometimes be debated, the midline catheter seems to be more and more used. the complications related to the use of picc lines have been well described in literature, whereas the comparison of the two catheter-related complications has been less analysed. the aim of this study is to compare the incidences of catheter-related bloodstream infections linked to piccs and midlines.

this single-center observational study will record and compare midline and picc line catheter-related bloodstream infections in the first 30 days after placement, catheter-related bloodstream infections being defined as clinical signs associated with a positive catheter culture (bacterial culture finding more than 103 cfu/ml) without any other infectious entry points. catheter indications, insertion conditions, incidence of haemorrhagic and thrombotic complications during the first 30 days will be analyzed.

Eligibility criteria:
inclusion criteria: * major ≥ 18 years old * opposition formulated exclusion criteria: * refusal of participation * patients under legal protection (guardianship, curatorship, etc.)

Keywords: venous access midline picc line catheter-related bloodstream infections
comparing analgesic regimen effectiveness and safety for surgery (cares) trial

Conditions: Surgery; Pain, Postoperative

Summary: this trial is being completed to compare two commonly used options to treat pain after surgery. participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. eligible participants will be randomized to 1 of 2 groups of medications (non-steroidal anti-inflammatory drugs (nsaids) plus acetaminophen or low dose opioids plus acetaminophen). it is anticipated that the nsaid group will have superior clinical outcomes and fewer side effects when compared to the opioid group.


Eligibility criteria:
inclusion criteria: * no significant analgesic medication use before surgery: for this study, significant analgesic medication use before surgery as use of prescriptions for opioid or nsaid medications in the past 30 days, or over-the-counter nsaid use on greater than 7 of 30 past days, as reported by the patient. * one of three common low-risk surgical procedures: for this study, the three-common low-risk surgical procedures will include laparoscopic gallbladder removal, inguinal hernia repair, and breast lumpectomy. exclusion criteria: * anticipated other surgery within 6 months or anticipated life expectancy of less than 6 months * patients with contraindications to nsaid drugs in the nsaid arm, opioid drugs in the opioid arm, or acetaminophen will be excluded. there are specific contraindications that will be reviewed per protocol.

Keywords: medications after surgery nsaids acetaminophen opioids laparoscopic gallbladder removal inguinal hernia repair breast lumpectomy analgesics, non-narcotic
initial staging of lobular breast carcinoma: head to head comparison of 68ga-fapi-46 and 18f-fdg pet/ct

Conditions: Lobular Breast Carcinoma

Summary: lobular breast cancer staging with 18f-fluorodeoxyglucose positron emission tomography (18f-fdg pet) is not optimal due to the poor accumulation of 18f-fdg in the tumour. through better sensitivity (and specificity), 68ga-fapi-46-46 pet should provide a more accurate staging of lobular breast cancer than 18f-fdg pet.

research hypothesis : through better sensitivity (and specificity), 68ga-fapi-46-46 pet should provide a more accurate staging of lobular breast cancer than 18f-fdg pet. participants with lobular breast carcinoma will then undergo 18f-fdg and 68ga-fapi-46 pet scan. primary objective of the study is to compare the sensitivity of 68ga-fapi-46 with the sensitivity of 18f-fdg in the detection of lobular breast carcinoma lesions, measured by positron emission tomography (pet). these results will be compared with the histological data collected before or during surgery (conventional histological data and immunohistochemical labeling of fapα on the sample obtained), clinical follow-up and any results of additional examinations carried out within the usual clinical follow-up of the patients. comparison of primary tumor and metastases uptake of 68ga-fapi-46 with the uptake of 18f-fdg, radiomic study of 68ga-fapi-46 pet and comparative radiomic study of 68ga-fapi-46 pet and 18f-fdg pet and comparison of the specificity of 68ga-fapi-46 with the specificity of 18f-fdg after a 12-month follow-up will also be performed as secondary objectives.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years * ecog from 0 to 2 * histological diagnosis of lobular carcinoma of the breast based on a breast biopsy * patient naïve to any treatment for lobular breast carcinoma * women of childbearing age should have an adequate method of contraception * patient having voluntarily accepted to participate in the study and signed the informed consent * minimum tumor stage iia * sufficient histological material in the biopsy or the surgical specimen, if the biopsy is insufficient exclusion criteria: * pet scan contraindications: severe claustrophobia, unbalanced diabetes during 18f-fdg pet scans (fasting capillary blood sugar ≥ 11 mmol) * hormone therapy started * 18f-fdg pet scan \> 21 days * pregnant women, parturients and nursing mothers * persons deprived of liberty by a judicial or administrative decision * persons admitted to a health or social establishment for purposes other than research * adults who are the subject of a legal protection measure or who are unable to express their consent

Keywords: 68ga-fapi-46 18f-fdg pet fapα staging
follow-up study of syb l-0501 in combination with rituximab to treat dlbcl

Conditions: Diffuse Large B Cell Lymphoma

Summary: this study is a follow-up study to update the survival time data (overall survival, progression-free survival, and duration of response) of the subjects who received syb l-0501 at least once in phase iii study of syb l-0501 in combination with rituximab to treat recurrent/relapsed diffuse large b-cell lymphoma study (2017002) by reviewing their follow-up information following the study completion of study 2017002. in this study, the follow-up information gathered until the end of the investigation period is reviewed after obtaining informed consent from the subjects or their legal representatives. accordingly, no intervention, such as administration of the investigational product or examination, will be performed. investigative methods 1. the investigator or subinvestigator gives an explanation to a subject or his/her legal representative to obtain written informed consent to provision of information pertaining to this study. 2. after obtaining informed consent, the investigator or subinvestigator reviews the follow-up information following the completion of study 2017002 in source documents regarding the following items: 1. survival status 2. aggravation (progression or recurrence) 3. drugs or procedures used for treatment of dlbcl or prophylaxis against its progression or recurrence 4. occurrence of other malignant tumors


Eligibility criteria:
inclusion criteria: 1. subjects who received the investigational product at least once in study 2017002 2. subjects who or whose legal representatives gave written informed consent to provision of data pertaining to this study exclusion criteria: 1. subjects whose death was confirmed during the outcome investigation period in study 2017002

Keywords: diffuse large b cell lymphoma
early oseltamivir treatment of influenza in children 1-3 years of age

Conditions: Influenza

Summary: the main purpose of this study is to assess the efficacy of early oseltamivir treatment (started within 24 hours of the onset of influenza symptoms) in preventing the development of acute otitis media as a complication of influenza in children aged 1-3 years.


Eligibility criteria:
inclusion criteria: * age 1-3 years * fever = or \> 38.0 c and at least one respiratory symptom or fever = or \> 38.0 c and a positive influenza rapid test exclusion criteria: * confirmed infection with any other respiratory virus than influenza. * suspicion of invasive bacterial infection requiring immediate admission to hospital * evidence of a poorly controlled underlying medical condition * known immunosuppression (malignancy, transplant, drugs) * known allergy to oseltamivir or paracetamol * received oseltamivir within 4 weeks * participation in another clinical trial with an investigational drug

Keywords: influenza children acute otitis media oseltamivir
the effect of cold salt water foot bath on the development of chemotherapy-induced peripheral neuropathy

Conditions: Breast Cancer Patients; Chemotherapy Induced Peripheral Neuropathy (CIPN); Paclitaxel-induced Peripheral Neuropathy

Summary: this prospective, randomised, controlled study was designed to evaluate the effectiveness of salt and unsalted cold water foot baths in preventing chemotherapy-induced peripheral neuropathy (cipn) in patients receiving paclitaxel. the study's sub-objectives were to minimise the development of cipn, reduce its severity and incidence of symptoms, and minimise its impact on daily life and activities. hypothesis(es): h1: salt cold water foot bath affects the development of chemotherapy-induced peripheral neuropathy. h2: there is an effect of unsalted cold water foot bath on the development of chemotherapy-induced peripheral neuropathy. h3: the effects of salt and unsalted cold water foot baths on the development of chemotherapy-induced peripheral neuropathy. h4: salt and unsalted cold water foot baths are more effective than standard clinical care in the development of chemotherapy-induced peripheral neuropathy. researchers will compare the salt cold water with the unsalted cold water, unsalted cold water and control group to determine whether the salt cold water has an effect on cipn. the experimental group and active comparator participants will continue the application for 12 cycles (12 weeks) of paclitaxel. the application will be applied by researcher tuba eryiğit. in addition, before each application for 12 weeks, the severity of cipn, its effect on daily life and grade will be evaluated. the control group will continue clinical routine care applications for 12 cycles (12 weeks). in addition, the severity of cipn, its effect on daily life and grade will be evaluated before each treatment in the same way as the experimental groups.


Eligibility criteria:
inclusion criteria: * women aged 18 and over. * conscious * speaking and understanding turkish * the diagnosis was breast cancer * those who will receive paclitaxel chemotherapy * these are patients who answered 'no' to the 'a' section of the cipnat scale exclusion criteria: * responding to the vibration test (if the practitioner does not feel the vibration when the patient says they feel the vibration, it means that neuropathy is present) * feeling pressure in one or none of the three areas on the plantar surface of the foot according to the monofilament test * previous chemotherapy-associated peripheral neuropathy * diagnosed with diabetes * open wounds or skin ulcers on the foot * with peripheral and central nervous system disease * peripheral vascular disease, * patients with bone or soft tissue metastases

Keywords: chemotherapy-induced peripheral neuropathy cold salt water foot bath breast cancer paclitaxel
silver agri age: longevity, intrinsic capacity and cognitive impairment into farmlands and natural environments: updating contexts following the "montessori" action

Conditions: Mild Cognitive Impairment (MCI)

Summary: this project aims to enhance the intrinsic capacities of elderly individuals with mild cognitive impairment by promoting innovative activities based on the montessori approach within the context of agricultural multifunctionality. by selecting a rural environment with educational characteristics, we aim to involve individuals with mild cognitive deficits and their families in a personalized therapeutic journey. through various activities, including horticulture, pet therapy, occupational therapies, sensory and food laboratories, we stimulate cognitive and motor skills, promoting a healthy and balanced lifestyle

promoting innovative activities following the "montessori" action in the context of the agricultural multifunctionality, in order to leverage the intrinsic capacity in older people with cognitive impairment. * identifying a rural environment with educational features. * identifying individuals with mild cognitive impairments and relations with their families. * outlining individual therapeutic goals for each participant through different activities: horticulture, pet therapy, occupational therapies, sensory laboratories, functional food laboratories for a healthy and balanced diet suitable for the first symptoms of dementia, physical activity and continuous social activity between different generations. * horticulture, pet therapy, occupational therapy, sensory labs, physical activity, and social activities in continuity between different generations. * spreading the results to a wide national and international audience.

Eligibility criteria:
inclusion criteria: * diagnosis of mild cognitive impairment (mci); * mini mental state examination ≥ 24; * ability and willingness to sign informed consent exclusion criteria: * mini mental state examination \< 24; * severe visual impairment; * inability to walk without help or assistance, tinetti's scale \<20

Keywords: older people mild cognitive impairment social farming montessori approach