Kornimate/medical-research-clean huggingface dataset:
measuring physical activity with activpal

Conditions: Neuromuscular Diseases

Summary: this study measures the level of physical activity in participants with neuromuscular disorders. the patient wears a small button like meter on their leg for a period of 1 week every 6 months over a period of 3 years. participants will also have a physical exam, six minute walk test,vital signs and questionnaires.

routine physical activity can be an important indicator of health across an individual's life span. nonetheless, the frequency of inactivity continues to be problematic for a large number of children and adolescents. adding to that challenge, fatigue has been described as a typical symptom of neurological diseases and disorders consumer wearables and accelerometers are becoming increasingly popular to track physical activities and monitor health and disease progression. with the increased adoption of activity trackers comes the increased generation of valuable individual-based data. generated data has the potential to provide detailed insights into the user's behavior and lifestyle. although methods for objectively measuring physical activity in children and adults in naturalistic settings are well established (i.e., accelerometry), they are most widely used on healthy individuals. due to cost and technical requirements, these technologies are limited which effects their wide-scale use. ultimately, this undermines efforts to evaluate physical activity changes and nuances among healthy and diseased populations. this is of particular interest in rare disease populations, specifically in neuromuscular diseases, where one can study a wide range of features that can be used to monitor an individual's sleep, vertical positioning, or overall physical activity. tracking physical activity can help provide clinicians with a more accurate disease profile and help to identify possible interventions. collection of this data could potentially provide valuable insight into an individual's daily routines, lifestyle, and behaviors.

Eligibility criteria:
inclusion criteria: * patients with a clinically or genetically confirmed neuromuscular disorder * control subjects who do not have a neuromuscular disease. * participants at least 1 years of age. exclusion criteria: * participant has a condition, which in the opinion of the investigator may compromise safety * participant has a condition, which in the opinion of the investigator may compromise or compliance

Keywords: muscle weakness muscle neuromuscular
trends in incidence and survivals for ovarian germ cell tumors: a 27-year population-based study

Conditions: Ovarian Cancer

Summary: trends in incidence and survivals for ovarian germ cell tumors: a 27-year population-based study

this is a chart review.

Eligibility criteria:
inclusion criteria: * patients with ovarian germ cell tumors in the last 27 years.
gator scales-whf: subcutaneous administration of lasix to eliminate symptoms of worsening heart failure

Conditions: Heart Failure; Volume Overload

Summary: the primary objective of the study is to develop, implement, and evaluate a site-specific clinical pathway for at-home treatment of eligible patients presenting to the clinic with worsening heart failure. the secondary objectives are: 1. to evaluate patient factors related to parenteral decongestion at home. 2. to evaluate the safety and device operation of lasix onyu treatment under circumstances that mimic real-world use. 3. to identify opportunities for process improvement before the routine implementation of the new clinical pathway.

we will conduct an open-label, non-comparative, real-world study to evaluate the effectiveness and feasibility of at-home decongestion treatment using lasix onyu in patients with worsening heart failure (whf). during a clinical visit at the uf heart failure clinic, emergency department, or clinical decision unit, we will assess whether a patient meets eligibility criteria for the study.

Eligibility criteria:
inclusion criteria: 1. age 18 or above 2. previously diagnosed with congestive heart failure (hfpef or hfref) 3. fluid overload due to worsening hf requiring parenteral diuretic treatment as assessed by at least 2 of the following: 1. bnp \> 200 2. jvp \> 10cmh20 3. presence of s3 4. le edema 5. weight gain of \> 5lbs in the past 5 days 4. failed oral uptitration of loop diuretic over the prior 5 days or presented with symptoms too advance to justify additional oral uptitration attempts to resolve congestion symptoms. 5. expected to require a minimum of three days of parenteral diuretic treatment 6. written informed consent 7. able and willing to operate lasix onyu and comply with study requirements or has a caregiver who can assume these roles. exclusion criteria: 1. age above 80 years 2. unable or unwilling to provide informed consent. 3. any medical condition or circumstances that would require further clinical investigation or hospitalization 4. presence or history of electrolyte abnormalities that may be exacerbated by parenteral loop diuretic treatment 5. home or current living environment not suitable for outpatient management and diuresis 6. pregnant or breastfeeding 7. unable to comply with clinic-required follow up procedure 8. baseline chronic renal disease with ckd stage v 9. any surgical or medical condition which, in the opinion of the investigator, may pose an undue risk to the subject, interfere with participation in the study or which may affect the integrity of the data
assessment of stroke volume and cardiac output in response to varying heart rates

Conditions: Vasovagal Syncope

Summary: the investigators will seek to determine the effects of different heart rates on both stroke volume and cardiac output using non-invasive hemodynamic assessments. in order to safely manipulate the hr, the investigators will study patients with permanent pacemakers in whom heart rate manipulation can be done in a safe and non-invasive manner.

permanent pacemakers have sometimes been used to treat patients with recurrent vasovagal syncope. this is because patients with vasovagal syncope often experience bradycardia at the time of their syncope. unfortunately, pacemakers are often ineffective in preventing syncope. classical cardiovascular hemodynamics would suggest that increasing the heart rate (hr; via pacemaker) should increase the cardiac output (co). this is because: co = hr x stroke volume (sv). the assumption is that the sv is fixed during manipulation of the hr. however, this might not be the case. as the number of beats per minute (hr) increases, the cardiac cycle length (r-r interval \[rri\]) shortens, as a function of simple math. this means that the time in cardiac systole shortens, and the time in cardiac diastole shortens. since cardiac diastole is when the heart fills up with blood, faster hr can be associated with decreased cardiac filling times. this, in turn, could compromise the sv. however, there is a paucity of data as to what happens to sv and co at different hr. further, it is possible that these effects will be different when a person is lying down supine versus when a patient is upright (when stroke volume will be lower). the investigators will seek to determine the effects of different hr on both sv \& co. in order to safely manipulate the hr, they will study patients with permanent pacemakers in whom hr manipulation can be done in a safe and non-invasive manner.

Eligibility criteria:
inclusion criteria: * age 18-70 years (inclusive) * implanted permanent pacemaker or implanted defibrillator capable of atrial and ventricular pacing * lv ejection fraction \>50% exclusion criteria: * unable or unwilling to provide informed consent * clinical need for a cardiac resynchronization device

Keywords: pacemaker stroke volume cardiac output heart rate
clinical significance of alveolar recruitment maneuver during bariatric surgery

Conditions: Obesity

Summary: the ventilation of the patient under general anesthesia is an old problem and extensively studied, especially in visceral surgery, higher risk of postoperative complications. studies have recently shown the impact of a lung-protective ventilation in visceral surgery, however obese patients are often excluded, and alveolar recruitment maneuver has never been studied independently. the investigators are conducting a randomized controlled prospective study to investigate the clinical value to achieve alveolar recruitment maneuver routinely in patients undergoing bariatric surgery. the objective is to show the reduction in dyspnea, oxygen dependency: reflection of atelectasis and the incidence of postoperative complications.


Eligibility criteria:
inclusion criteria: * patients surgery for bariatric surgery (sleeve, gastric bypass, gastric banding ablation) * planned surgery, * asa 1-2-3, exclusion criteria: * severe copd * severe emphysema, * pneumothorax, * right sided heart failure, * severe heart failure * emergency surgery, * asa 4
evaluation of moderate to severe influenza outcomes in children

Conditions: Influenza; Otitis Media; Lower Resp Tract Infection; Encephalitic Infection; Myositis Viral; Fever

Summary: the purpose of this study was to determine whether moderate-severe endpoints (including high fever, lower respiratory tract disease, acute otitis media, or serious extra-pulmonary complications) were predictive of hospitalization, intensive care admission, antibiotic use and other complications in children under 8 years of age.

this prospective observational study aimed to determine the risk difference of hospitalization due to moderate to severe influenza compared with mild influenza among children aged 6 months to 8 years who were evaluated at children's hospital colorado emergency department and urgent care during the 2016-2017 influenza season. in addition, the study intended to evaluate the risk difference for other health outcomes such as icu admission, antibiotic and antiviral use, caregiver and child absenteeism and recurrent (\>1) healthcare visits, and to compare the healthcare costs associated with management of moderate to severe versus mild influenza in children. children who presented to children's hospital colorado emergency department (ed) and urgent care affiliated sites (north campus urgent care) with an influenza-like illness from december 2016 to april 2017 and during the 2016-2017 influenza season, were eligible for the study. once enrolled in the study, the investigators collected respiratory samples (nasal swab specimens) for influenza testing by pcr, sociodemographic and clinical data including variables of interest outlined above, and followed the clinical outcome of these children for 14 days after their initial presentation. some of the variables of interest the investigators collected are shown below.

Eligibility criteria:
inclusion criteria: * age 6 months to \< 8 years * presentation to one of the study sites with signs and symptoms of influenza-like illness (temperature of \>37.8⁰c and at least one of the following: cough, sore throat, runny nose or nasal congestion) * parents or guardians agreeing and consenting to medical information release, respiratory specimen collection and testing, email/phone call follow up and collection of leftover blood samples obtained during routine clinical care * patients seen during the 2016-2017 influenza season exclusion criteria: * respiratory symptom duration \> 14 days * nurse only visit * enrollment in the study within prior 14 days

Keywords: hospitalization intensive care unit school absenteeism work absenteeism
microperimetry in macular edema

Conditions: Macular Edema; Uveitis

Summary: in uveitic patients with fluorescein angiographically proven macular edema, a fundus related microperimetry is performed and results are correlated with foveal thickness as measured with optical coherence tomography (oct).


Eligibility criteria:
inclusion criteria: * patients with noninfectious uveitis, macular edema exclusion criteria: * pregnancy, fluorescein allergy

Keywords: microperimetry macular edema uveitis retinal sensitivity as measured with fundus related microperimetry
co morbid attention deficit and hyperactivity disorder(adhd) and developmental co ordination disorder (dcd)

Conditions: Attention Deficit Disorder With Hyperactivity; Developmental Coordination Disorder

Summary: this study aims to establish and present the prevalence figures and demographics of the co-morbidity of adhd and dcd. it further aims to design an exercise intervention, to be utilised in the management of the symptoms of both conditions. furthermore, it aims at establishing the efficacy of this exercise intervention, when compared with the current and most commonly used intervention, that is: neurostimulant drugs.

this study is an experimental design, having three phases. the study looks at children, aged 8 to 9, in remedial units or lsen classes, in and around durban, kzn, sa; who have been diagnosed with adhd/add. phase 1: teachers of the children identified with adhd/add, will be asked to complete a modified teacher conner's rating, to confirm the diagnosis of adhd/add. the parent will then be asked to complete a dcd questionnaire (dcdq) to give the pi an idea of whether co-ordination difficulties exist. the pi will then administer a motor assessment battery for children (mabc) to confirm the diagnosis of dcd. from the scores derived from the 3 above tests, co-morbidity will be diagnosed. the prevalence figures of co-morbidity will be calculated and presented. demographics of prevalence figures will be given: gender, population group, average age. phase 2: the exercise intervention will be designed, drawing from the literature and similar interventions already used in various publications. this programme will be validated by experts (physiotherapists and o.ts from special needs schools) and when 70% consensus is reached on all aspects of the programme, the final version will be drafted. phase 3: the children found to have both conditions, in co-morbidity, will be assigned to one of 4 groups, according to parental choice, medical advice from paediatricians, gps etc and an intervention a child is already on. the four groups will be: medication, exercises, medication plus exercises and a control group. the intervention designed in phase 2 will be administered to the two groups opting for the exercise intervention, for a minimum of 8 sessions. the 3 pre intervention scores (conner's, dcdq and mabc) will be derived from phase 1, post intervention scores will be done 6 months after completion of the intervention, as it is stipulated by the rules of the mabc that the test may not be repeated sooner. the pre and post intervention scores will be compared to calculate improvement and average improvement within each group, will be calculated, to establish which intervention or combination of interventions, is the most effective.

Eligibility criteria:
inclusion criteria: * age 8 to 9, diagnosed with adhd, in remedial unit or lsen class, in mainstream school in durban kzn sa. exclusion criteria: * any child having an obvious physical disability, neurological condition, musculoskeletal condition, psychiatric disorder or genetic disorder. any child below age 8 and above age 9.

Keywords: adhd/add dcd exercises neurostimulant drugs
real-time attended home-polysomnography through telematic data transmission

Conditions: Obstructive Sleep Apnea

Summary: the purpose of this study is to develop an efficient home-based polysomnography device, which allows, through gprs,continuous real-time monitoring from the sleep lab based in the hospital, in order to decrease the failure rate of home-based recordings.


Eligibility criteria:
inclusion criteria: * clinical suspicion of osa * 18 y old exclusion criteria: * restrictive respiratory disorders * distance home-hospital exceeding 30 km.

Keywords: sleep apnea polysomnography telemedicine
parameters related to physical activity level in sci

Conditions: Spinal Cord Injuries; Respiratory Complication; Cardiovascular Complication

Summary: spinal cord injury (sci) is a devastating health condition associated with permanent disability and reduced life expectancy. it is stated that its annual incidence worldwide varies between 12.1 and 57.8 per million, and its prevalence varies between 236 and 1009 per million. sci negatively affects the physical, psychological, and social well-being of individuals by causing sensory, motor, and autonomic dysfunction. the level of disability associated with sci is different for each injury and varies depending on the level and type of injury. however, physical activity (pa), cardiovascular fitness, and respiratory system are commonly observed to be affected in most individuals with sci. due to inadequate control of somatic and autonomic systems, a decrease in the cardiovascular response to pa and exercise occurs. a decrease in pa level and systemic disorders after injury promote sedentary behavior and negatively affect cardiovascular fitness in individuals with sci. cervical and thoracic spinal cord injuries compromise the function of the respiratory muscles and significantly impair both inspiratory and expiratory function. it also interrupts the sympathetic innervation of the lungs and creates restrictive changes in the physiological and mechanical properties of the lungs. the broad effects of sci on lung capacity may have implications for cardiovascular fitness. adequate ventilation is critical to provide adequate oxygen to working muscles during prolonged physical activities. during moderate and high-intensity physical activities, ventilation increases in proportion to oxygen consumption to maintain arterial oxygen concentration and allow continuous pa. knowing the relationship between pa, cardiovascular fitness, and respiratory parameters after sci is essential in guiding the course of rehabilitation after sci. battikha et al. they reported that respiratory capacity plays an important role in limiting exercise capacity in individuals with sci. however, the relationship between pa and cardiovascular fitness and respiratory parameters has not been fully examined in individuals with sci. in this study, the investigators hypothesize the relationship between pa, cardiovascular fitness and respiratory parameters. accordingly, this study aims to determine the relationship between pa, cardiovascular fitness and respiratory parameters in individuals with sci.


Eligibility criteria:
inclusion criteria: * classified as group a, b, c or d (diagnosed with spinal cord injury) according to the american spinal injury association (asia), * fully or partially wheelchair dependent * having the upper extremity muscle strength required to use a wheelchair * those who are over 18 years old * patients without cognitive impairment exclusion criteria: * those with any progressive disease * bedridden, * patients with severe cognitive impairment
spo2 accuracy of noninvasive disposable pulse oximeter sensor

Conditions: Healthy; Hypoxia

Summary: the purpose of this clinical study is to validate the spo2 accuracy of the stryker sustainability solutions pulse oximetry sensors during non-motion conditions over the range of 70-100% sao2 as compared to arterial blood samples assessed by co-oximetry. the end goal is to provide supporting documentation for the spo2 accuracy validation of the reprocessed sensors.

in this study, the level of oxygen within the blood will be reduced in a controlled manner by reducing the concentration of oxygen the participant breathes. the accuracy of a noninvasive pulse oximeter sensor will be assessed by comparison to the oxygen saturation measurements from a laboratory blood gas analyzer. it is required that the accuracy root mean square (arms) performance of the stryker pulse oximetry sensors will meet a specification of +/-3% or better in non-motion conditions for the range of 70 - 100% sao2 (typically, saturation is determined once with air breathing and then at one of 3 levels, e.g. 95%, 85%, and 75% saturation for about 30-60 seconds at each level), thereby demonstrating an acceptable spo2 accuracy performance specification.

Eligibility criteria:
inclusion criteria: * good general health with no evidence of pre-existing medical problems * fluent in both written and spoken english * must be able to review informed consent and is willing to comply with study procedures exclusion criteria: * obesity (bmi \>30) * known history of heart disease, lung disease, kidney or liver disease * prior diagnosis of asthma, sleep apnea, or use of cpap * diabetes * clotting disorder * hemoglobinopathy or history of anemia that in the opinion of the investigators would make them unsuitable for study participation * any serious systemic illness * current smoker * any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigator would interfere with the sensors working correctly * history of fainting or vasovagal response * history of sensitivity to local anesthesia * prior diagnosis of raynaud's disease * unacceptable collateral circulation based on exam by investigators (allen's test) * pregnant, lactating, or trying to get pregnant * unable or unwilling to provide informed consent, or unable or unwilling to comply with study procedures * any other condition which in the opinion of the investigators would make them unsuitable for the study
ultrasonographic assessment of stomach in two different fasting guidelines

Conditions: General Anesthesia

Summary: oral carbohydrate loading until 2 h before surgery is well known to be effective in facilitating postoperative recovery and reducing complications, by maintaining homeostasis. however, there are still concerns in implementing this as a universal fasting guideline, because of the risk of pulmonary aspiration. therefore, we designed this study to compare the two preoperative fasting guideline: (1) keep fasted from midnight until surgery, and (2) oral carbohydrate beverage 800 ml from midnight until 2 h before surgery.


Eligibility criteria:
inclusion criteria: * adult aged from 18 to 70 * american society of anesthesiologists (asa) class i or ii * absence of pregnancy * not on lactation at the time of surgery exclusion criteria: * delayed gastric emptying (gerd, gastrointestinal disease, diabetes) * contraindicated to nsaid or opioid * mental disorders * alcoholism * drug abuse