Kornimate/medical-research-clean huggingface dataset:
repetitive transcranial magnetic stimulation of the dmpfc for anorexia and bulimia: an open-label case series

Conditions: Bulimia Nervosa; Anorexia Nervosa

Summary: this project proposes to perform a pilot study of fmri targeted dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation (dmpfc-rtms) on individuals diagnosed with bulimia nervosa (bn) and anorexia nervosa (an). the dmfpc is a novel target for rtms, is heavily implicated in the regulation of mood and affect, and has been suggested to be involved in an, bn, major depression, ocd, and ptsd. improved function in this area might lead to reduced an and bn symptoms, such as bingeing, purging, and over-activity, perhaps by improved regulation of mood and affect. improvements in important areas of comorbidity might allow for better response to intensive treatment for an and bn, and reduce relapse rates after such treatment. the dmpfc may be a more appropriate target for compared to the dorsolateral prefrontal cortex (dlpfc), which has typically been the focus of stimulation in the past. our initial preliminary pilot work has noted unexpected and significant improvements in some core ed symptoms (bingeing and purging) and in important areas of comorbidity (ocd and ptsd), along with expected improvements in mood. these changes have allowed some treatment resistant patients to either complete intensive treatment or be successful in maintaining their progress post intensive treatment. subjects will receive up to 30 sessions of bilateral dmpfc-rtms. response will be evaluated clinically, via psychometric measures, and pre and post fmri.


Eligibility criteria:
inclusion criteria: patients will be included if they: * are voluntary and competent to consent to treatment. * have met dsm-5 diagnostic criteria for anorexia nervosa or bulimia nervosa, over the last 6 months at minimum exclusion criteria: patients will be excluded if they have: 1. past or current neurological illness 2. comorbid schizophrenia 3. current suicidal intent or plan 4. contraindications to mri or rtms (e.g., metallic implants/foreign bodies) 5. pregnancy.

Keywords: eating disorders rtms anorexia bulimia
antimicrobial stewardship program (asp) in patients with a sore throat

Conditions: Tonsillitis; Streptococcus Pharyngitis; Sore Throat; Pharyngitis; Pharyngitis Bacterial

Summary: the investigators have developed an antibiotic stewardship program (asp) to increase adherence to the swedish guidelines for managing patients with a sore throat. this is a randomized controlled trial where primary health care centers are randomised to get the asp or not. the adherence to the swedish guidelines are measured in all participating centers.

the investigators have developed an antibiotic stewardship program (asp) to increase adherence to the swedish guidelines for managing patients with a sore throat. this is a randomized controlled trial where primary health care centers are randomised to get the asp or not. the adherence to the swedish guidelines are measured in all participating centers 6 months before and after implementation of the asp. the asp consists of educational meetings at the clinic for medical practitioners and nurses being informed about current guidelines, seeing their clinics adherence to the guidelines as well as discussing cases.

Eligibility criteria:
inclusion criteria: * being a primary health care center in the vastra gotaland region, sweden accepting participation exclusion criteria: * none

Keywords: streptococcus pyogenes infection randomized controlled trial
transcranial direct current stimulation for freezing of gait

Conditions: Parkinson's Disease

Summary: this study will evaluate the effects of transcranial direct current stimulation (tdcs) in combination with locomotor training in patients with parkinson's disease (pd) and freezing of gait (fog).


Eligibility criteria:
inclusion criteria: 1. age 18- 80 2. parkinson's disease stages 2-3 hoehn and yahr. 3. presence of freezing of gait 4. stable medication regimen 5. time to complete tug \>12 seconds exclusion criteria: 1. medical condition that would interfere with walking and training for 30 minutes 2. unable to perform timed up and go in the off condition 3. history of seizures 4. implanted deep brain stimulator, pacemaker or any other electronic device. 5. dementia 6. adults unable to consent, individuals who are not yet adults (infants, children, teenagers) pregnant women, prisoners will not be considered for participation

Keywords: transcranial direct current stimulation neuromodulation
evaluation of the use of cefoxitin in combination in continuous parenteral administration in the treatment of bone and joint infections

Conditions: Antibiotic Reaction; Bone and Joint Infection

Summary: cephamycin related to 2nd generation cephalosporins, the use of cefoxitin has long been limited to antibiotic prophylaxis. because of its spectrum (sensitive staphylococci, enterobacteria including esbl, streptococci, anaerobes), its stability and its low cost, it could be useful in curative bone and joint infections, especially in case of infection polymicrobial disease in patients for whom antibiotic alternative per os is limited.


Eligibility criteria:
inclusion criteria: * patients havind had a bon and joint infeciton treated with cefoxitin in combination in continuous parenteral administration exclusion criteria: -

Keywords: cefoxitin bone and joint infection
digital foot check by using the d-foot, a new software

Conditions: Diabetic Foot; Diabetic Foot Ulcer; Diabetic Foot Ulcer Neuropathic; Neuropathy;Peripheral; Foot Deformities; Foot Callus

Summary: patients with diabetes should be thoroughly examined before they are provided with insoles and shoes. in the study the feet are examined with the help of a new software, the d-foot. d-foot includes questions and surveys. the aim of the of the study is evaluate how the patients experience the visit at the department of prosthetics \& orthotics based on the digital foot check.

patients with diabetes should be thoroughly examined before they are provided with insoles and shoes. the purpose of the foot examination is to determine whether the patient is at risk of developing diabetic foot ulcers (dfu). risk factors are: neuropathy, peripheral angiopathy, foot deformities, skin pathologies, earlier history of dfu/amputation. with effective control and examination of the feet, foot complications, such as dfu, can be prevented. in the study the feet are examined with the help of a new software, the d-foot. d-foot includes questions and surveys. the aim of the of the study is evaluate how the patients experience the visit at the department of prosthetics \& orthotics based on the digital foot check.

Eligibility criteria:
inclusion criteria for patients: * to be diagnosed diabetes * age ≥ 18 years * to understand the swedish language. inclusion criteria for certified prosthetist \& orthotists * to work at the department * to be assigned to work with patients with diabetes at risk of developing foot ulcers. * have completed the introduction course d-foot

Keywords: risk factor software orthotics
ernie4: urine and crp point-of-care test in acutely ill children

Conditions: Infection

Summary: this study aims to assess the accuracy of a novel urine test for diagnosing urinary tract infections in acutely ill children presenting to ambulatory care. the accuracy of this novel test will be compared to the accuracy of conventional dipstick testing. in addition, the evidence on urine tests will be added to the existing algorithm for diagnosing serious infections in children. finally, the study aims to describe the relation between the crp level at study entry and the duration of symptoms and final diagnosis over the following 30 days.

the design is a cross-sectional cohort study with a nested longitudinal follow-up in acutely children presenting to ambulatory care. the cross-sectional cohort study will compare an innovative urine test with conventional dipstick testing to establish their relative accuracy to diagnose urinary tract infections, and construct an algorithm consisting of clinical features, urine test results and crp point-of-care testing to identify serious infections. the longitudinal follow-up study will describe illness trajectories of children with an intermediate crp test result (5-80 mg/l) at first contact. the study will run in general practices and community paediatrics in flanders. recruitment to the study is expected to last 18 months, with each patient entering the study only once. children and their parents/guardians will be approached for possible participation in the study by practice staff. there is only one study visit. those who agree to participation via written informed consent will have demographics and clinical features recorded. all children will be asked to provide a urine sample on study entry. subsequently, crp point-of-care testing will be conducted in all children testing positive on a clinical prediction rule, and in a random sample of children testing negative on that rule. follow-up information for all children will be collected using general practice notes, hospital records and direct patient/parent contact. treatment and other management decisions will be left to the treating physicians' discretion.

Eligibility criteria:
inclusion criteria: * aged 3 months to 18 years * presenting to a general practice or community paediatrics * acute illness of a maximum of 10 days * parent or guardian is willing and able to give informed consent for participation exclusion criteria: * clinically unstable warranting immediate care * urinary catheter in situ * immunosuppressant medication taken in the previous 30 days * trauma is the main presenting problem * antibiotics taken in the previous 7 days * children who present to community paediatrics as a result of direct gp referral

Keywords: diagnosis sensitivity and specificity serious infections
a long-term safety study of orforglipron (ly3502970) in participants with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to determine the long-term safety of the study intervention orforglipron as a monotherapy or in combination with oral antihyperglycemic medication. this study includes 3 periods as follows: * screening and lead-in period: up to 4 weeks * treatment period: 52 weeks, including 20 weeks of dose escalation, and * safety follow-up period: 2 weeks.


Eligibility criteria:
inclusion criteria: * have type 2 diabetes (t2d) * have hba1c ≥7.0% (≥53 mmol/mol) to ≤10.5% (≤91 mmol/mol) as determined by the central laboratory at screening. * are of stable weight (±5%) for at least 90 days prior to screening and agree to not initiate an intensive diet or exercise program during the study with the intent of reducing body weight other than the lifestyle and/or dietary measures for diabetes treatment. * have a bmi ≥23.0 kilogram/square meter (kg/m²) at screening. exclusion criteria: * have type 1 diabetes (t1d). * have a history of severe hypoglycemia or hypoglycemia unawareness within the last 6 months prior to screening, or between screening and randomization. * have new york heart association functional classification iv congestive heart failure. * have had any of the following cardiovascular (cv) conditions within 60 days prior to screening, or between screening and randomization. * acute myocardial infarction * cerebrovascular accident (stroke), or * hospitalization for congestive heart failure * have acute or chronic hepatitis and pancreatitis
effect of inflation on the angiographic result after balloon angioplasty in the femoropopliteal segment

Conditions: Femoropopliteal Arterial Stenosis

Summary: percutaneous angioplasty with balloon dilation is the method of choice for the treatment of most femoropopliteal artery lesions. after balloon dilatation, arterial wall dissection with flow limiting dissection or recoil with residual stenosis often require additional procedures such as stent placement or prolonged balloon dilation. a shorter balloon inflation time of 30 sec will be accompanied by a higher number of flow limiting dissection or recoil, demanding a time consuming and expensive stent placement or balloon redilatation. the effect of different balloon inflation times has only been assessed ones in peripheral balloon angioplasty with better outcomes after prolonged balloon inflation.


Eligibility criteria:
inclusion criteria: * patients with symptomatic atherosclerotic stenotic lesions of the femoropopliteal artery suitable for angioplasty in the adult population exclusion criteria: * artery lesions shorter than 1 cm and longer than 10 cm length, total occlusions, severe calcification, previous angioplasty with current restenosis, previous stenting with current insistent restenosis and subintimal recanalization of the lesion * no pregnant and nursing women will be included.
nutrition in pregnancy, birth weight, and childhood asthma

Conditions: Lung Diseases; Asthma

Summary: to evaluate the role of maternal diet and birth weight in the etiology of childhood asthma and other allergic disorders.

background: asthma is one of the most common chronic diseases diagnosed among children in the developed world, and its prevalence in western industrialized countries is increasing at an alarming rate. little information is currently available regarding the role of maternal diet during pregnancy and birth weight in the risk of childhood asthma. design narrative: this longitudinal prospective study takes advantage of the resources provided by project viva, an ongoing prospective cohort study of pregnant women and their infant offspring among members of harvard pilgrim health care, a large managed care organization in new england. data already available from project viva include detailed dietary data on mother and infant, along with data on anthropometric, social, environmental, demographic, economic, psychological, and lifestyle variables. the study will follow the project viva cohort until ages 3 to 4 years.

Eligibility criteria:
no eligibility criteria
mri and diffusion imaging of eloquent brain areas to optimize brain tumor resection planning

Conditions: Brain Cancer

Summary: many patients with brain tumors require surgery. some patients have brain tumors near important parts of the brain. these brain areas have roles in language or motor function. avoiding these motor and language areas helps to prevent neurological deficits. the investigators are studying the parts of the brain involved in motor and language. patients usually get functional mri (fmri) or resting-state fmri (rs-fmri) for gray matter mapping and diffusion tensor imaging (dti) or diffusion spectrum imaging (dsi) for white matter mapping. these special mri sequences are used to plan surgery. patients are scheduled to have imaging to help plan for possible surgery. some patients may require stimulation during surgery to motor and language areas. in patients who require stimulation as part of their standard of care, the investigators will compare the investigators imaging results with the stimulation results. the purpose of this study is to improve mri mapping of the motor and language pathways in the brain. the scans are necessary stimulation for this protocol are part of the standard of care. in other words, these tests are done as part of the best possible care even if they did not join this study. the investigators are studying new techniques for analyzing the mri data. these new techniques may give the doctor a better view of where the brain tumor is located relative to important parts of the brain. the investigators will only perform the test sequences that are necessary for mapping the tumor. most patients will require both fmri and dti. some patients may only require fmri or dti. the investigators may also ask to perform optional sequences during the scan. multi-echo is an modified form of fmri. dsi is a modified form of dti. these optional sequences are for research only. the patient would not get these sequences if they do not enroll in this study.


Eligibility criteria:
inclusion criteria: * primary or secondary brain tumor (enhancing mass lesion ± nonenhancing abnormality), known or suspected, located near (\< 2 cm) any portion of the motor cortex, motor pathway, language cortex, or language pathway as determined on anatomical images; * planned resection of the tumor; * fmri and/or dti required for preoperative imaging as part of the standard of care * patient and/or guardian is able to provide written informed consent prior to study registration * age ≥ 18 years old exclusion criteria: * unable to tolerate mri and/or perform fmri tasks (e.g., severe claustrophobia or pacemaker or aneurysm clip that precludes mri scan) * pregnant or nursing female

Keywords: fmri dti dsi tractography neurological/physical testing motor and language pathways resting state fmri 12-008
ecmo for lung transplantation in cystic fibrosis patients

Conditions: Cystic Fibrosis

Summary: cystic fibrosis (cf) is the most common genetically inherited disease in the caucasian population. bilateral lung transplantation (lutx) is a viable option for these patients. frequently, the surgical operation of lutx is complicated by hemodynamic instability, intractable hypoxia and respiratory acidosis. for these reasons, intraoperative extracorporeal life support - ecls- is required. data on predictors of use of intraoperative ecls in cf patients undergoing lutx is scarce. aim of this retrospective observational study was 1) to find possible risk factors at the time of enlistment associated with the intraoperative use of ecls and 2) to compare the outcomes of cf patients treated with ecls during lutx or not.

cystic fibrosis (cf) is the most common genetically inherited disease in the caucasian population and damages multiple organ systems (i.e., upper and lower respiratory tract, pancreas, liver). respiratory manifestations include reduction of mucus clearance, chronic pulmonary infections and bronchiectasis, causing progressive respiratory failure that is the primary cause of death in cf patients. moreover, advanced cf is complicated by pulmonary hypertension, right ventricular hypertrophy and right heart failure. bilateral lung transplantation (lutx) is a viable option for these patients, providing a significant survival benefit as compared to no-lutx. frequently, the surgical operation of lutx is complicated by acute heart failure (due to sequential pulmonary artery cross-clamping and/or hemodynamic instability), severe intractable hypoxia and respiratory acidosis. for these reasons, extracorporeal life support - ecls - (either in the form of cardiopulmonary bypass -cbp- or extracorporeal membrane oxygenation -ecmo) is frequently required. to now, literature data on predictors of use of intraoperative ecls in cf patients undergoing lutx is scarce. notably, the use of ecls during lutx has been associated with a higher risk of primary graft dysfunction (pgd). moreover, knowing that a patient has a high risk for the use of ecls may allow appropriate clinical planning of the procedure with eventual elective ecmo connection. the investigator's institution (fondazione irccs ca' granda - ospedale maggiore policlinico) is an italian tertiary referral center for cf and lutx, as well as for respiratory failure and ecmo support. aim of this retrospective observational study was 1) to find possible risk factors at the time of enlistment associated with the intraoperative use of ecls and 2) to compare the outcomes of cf patients treated with ecls during lutx or not.

Eligibility criteria:
inclusion criteria: * cf * undergoing lutx exclusion criteria: * single lung transplantation * re-transplantation * missing medical records.

Keywords: cystic fibrosis lung transplantation extracorporeal membrane oxygenation
tackling 30-day readmissions in patients with cirrhosis: the saltyfood trial

Conditions: Hepatic Encephalopathy; Ascites; Liver Diseases; Cirrhosis

Summary: the purpose of this study is to determine the feasibility of a home meal delivery program for patients with cirrhosis and ascites and to determine the effectiveness of a salt-restricted (2 gram sodium) meal delivery program in reducing the need for therapeutic paracenteses and/or all-cause re-admissions for these patients. many patients with cirrhosis don't have enough nutrients in the body and are frail and these meals may help them maintain a good diet and lead to improved quality of life.


Eligibility criteria:
inclusion criteria: * adult 18 years or older of age * clinical diagnosis of cirrhosis with ascites. diagnosis of cirrhosis will be based upon: 1. liver biopsy, or 2. history of cirrhosis complication: ascites, variceal bleeding, hepatic encephalopathy, or 3. 2 of the following 4 criteria: i. ultrasound (us), computerized axial tomography (ct) or magnetic resonance imaging (mri) imaging findings of cirrhosis (cirrhotic appearing liver, splenomegaly, varices, ascites) ii. fibroscan liver stiffness score \>13 kpa iii. laboratory testing: aspartate aminotransferase (ast)/platelet ratio index (apri) \>2.0 iv. ct, mri or esophagogastroduodenoscopy (egd) showing presence of esophageal varices * 3) at least one of the following: any cause hospitalization within 90 days or outpatient therapeutic paracentesis within 30 days exclusion criteria: * language barriers that cannot be surmounted with in-person interpreters * estimated life expectancy \< 3 months * pregnancy (self-reported) * unable or unwilling to provide consent * history of liver transplant * planned discharge to nursing facility * anuria or serum creatinine \> 2.0 mg/dl * uncontrolled hepatic encephalopathy

Keywords: hepatic encephalopathy ascites liver diseases cirrhosis
the epidemiologic study of human papillomavirus infection and related diseases

Conditions: Human Papillomavirus Infection; Genital Warts

Summary: primary purpose:evaluate the prevalence and incidence of hpv infection and related diseases in subjects. secondary purpose:analyze risk factors of hpv infection and related diseases.


Eligibility criteria:
inclusion criteria: * ages 18 to 55 years; * residents of the study site; * at least one sex partner; * be able to understand and comply with the request of the protocol. exclusion criteria: * pregnant; * has received hpv vaccines.

Keywords: hpv genital warts
a study to assess the safety of using fibroblast growth factor-2 with periodontal surgery in japan (phase 3)

Conditions: Periodontitis

Summary: this study aims to investigate the safety in using trafermin (recombinant human basic fibroblast growth factor) with periodontal surgery.


Eligibility criteria:
inclusion criteria: * vertical intrabony defect from radiographs at baseline * age of 20 years or older exclusion criteria: * using an investigational drug within the past 24 months * coexisting malignant tumour or history of the same * coexisting diabetes (hba1c 6.5% or more) * taking bisphosphonates * coexisting gingival overgrowth or history of the same

Keywords: trafermin periodontitis