Kornimate/medical-research-clean huggingface dataset:
hysteroscopy before in vitro fertilization - does it improve the outcome?

Conditions: Subfertility; Infertility

Summary: by randomizing sub-fertile women to either control or office-hysteroscopy in the circle prior to ivf or icsi (intracytoplasmatic sperm injection ) treatment, we aim to enlighten whether hysteroscopy with endometrial biopsy increases pregnancy rates in the intervention group.

background a tenth of a population in denmark today is the result of assisted fertility, including ivf and icsi. in roughly 40 % of these subfertile women the reason is unknown. standard initial procedures include transvaginal ultrasonography, with or without saline infusion to detect intrauterine abnormalities that might explain the infertile condition. the golden standard to detect intrauterine abnormalities is hysteroscopy. such abnormalities can be detected in a fourth of this population. earlier studies indicate that the hysteroscopy alone - without correcting any abnormalities, affects ivf/isci outcome positively. aim by randomizing patients referred to the fertility clinic to ±office-hysteroscopy in circle prior to ivf/isci, we aim to enlighten whether mini-hysteroscopy with endometrial biopsy will increase the fertility by looking at pregnancy rates as our main outcome. method women signed up for second ivf/isci treatment will be recruited, after signed consent they are randomized to either office-hysteroscopy or nothing before standard treatment in the fertility clinic. mini-hysteroscopy is a standard procedure in our gynecological outpatient clinic. the procedure is done without any anesthetics. only women with normal intrauterine conditions will be enrolled in this protocol. when the fertility clinic has a positive serum-hcg (human chorionic gonadotropin ) and a positive transvaginal sonography, pregnancy is confirmed. if negative serum-hcg, negative pregnancy will be registered.

Eligibility criteria:
inclusion criteria: * women submitted to ivf or isci treatment * age \> 18 years * women able to read, speak and understand danish * written consent exclusion criteria: * intrauterine abnormalities * infection * bmi \> 35 * known intrauterine cause to the infertile condition * abuse of alcohol or drugs * untreated medical condition * pregnancy

Keywords: ivf treatment office-hysteroscopy endometrial biopsy
bacterial infections in cirrhotic patients with acute severe liver injury

Conditions: Cirrhosis, Liver; Bacterial Infections; Acute Liver Injury

Summary: acute hepatic insults including hepatitis flare-up, active alcohol assumption and hepatotoxic drug use are common in patients with cirrhosis especially in eastern countries.these patients are at high risk of developing acute-on-chronic liver failure (aclf) and associated with high short-term mortality. and the natural history of these patients is frequently complicated by bacterial infections, which lead to deterioration of underlying diseases. the present study is aimed to investigate the prevalance and risk factors of bacterial infections in those patients and its impact on in-hospital/short-term mortality.


Eligibility criteria:
inclusion criteria: 1. the presence of cirrhosis confirmed by liver biopsy, endoscopy, radiological examination, or clinical evidence of prior hepatic de-compensation; 2. flare up of acute severe liver injury within one month before enrollment. acute severe liver injury is defined as: increase of serum bilirubin \>=85mmol/l and international normalized ratio (inr)\>=1.5 with a definite hepatic insult. exclusion criteria: (1)pregnancy; (2) disseminated maliganancy; (3)previously received a liver transplant; (4) hiv infection;
dna methylation for screening uterine cervical lesions: a case-control study

Conditions: DNA Methylation; Uterine Cervical Cancer; High Grade Squamous Intraepithelial Lesions; Low Grade Squamous Intraepithelial Lesions

Summary: the primary objective of this study is to compare the testing of dna methylation, high-risk hpv subtypes, and cytology with the definite histological results in a case-control study, so as to determine the accuracy of dna methylation in the screening of uterine cervical lesions. this study will include 300 patients with definite histological results, with 100 of cervical inflammation or low grade squamous intraepithelial lesions (lsil), 100 of high grade squamous intraepithelial lesions (hsil), and 100 of uterine cervical cancer. all the cervical specimens of cytology collected in the clinical settings will be utilized for the testing of dna methylation, high-risk hpv subtypes and thin prep liquid-based cytology test (tct). the sensitivity, specificity, positive predictive value and negative predictive value were calculated based on the known histological results. the differences of dna methylation with high-risk human papillomavirus (hpv) and tct will also be analyzed. the testing of dna methylation will be performed with the methylation-specific polymerase chain reaction (pcr). the tct and hpv testing will be performed with the roche kits.


Eligibility criteria:
inclusion criteria: * confirmed cervical histology within one month when collecting cervical cytology * aged 18 years or older * signed an approved informed consents exclusion criteria: * not meeting any of the inclusion criteria
comparative study to evaluate the efficacy of ultrasound-guided pericapsular nerve group (peng) block versus fascia iliaca compartment (fic) block on the postoperative analgesic effect in patients undergoing hip surgeries under spinal anesthesia.

Conditions: Hip Fractures

Summary: fractures in and around the hip are quite common irrespective of both the young and elderly population groups and are associated with extreme pain. a hip fracture is a serious injury, with complications that can be life-threatening and is a common orthopedic emergency in the elderly. early surgery within 48 h of fracture has shown to decrease the complication and mortality rates.


Eligibility criteria:
inclusion criteria: * forty -two patients above 18 years of age belonging to the american society of anaesthesiologists (asa) physical status classes i and ii scheduled for hip surgery will randomly be allocated into two groups. group a (peng block) will receive us - guided peng block and group b (fic block) will receive us - guided fic block for postoperative pain relief. exclusion criteria: * patient refusal. * patient with significant neurological, psychiatric or neuromuscular disease. * alcoholism. * drug abuse. * pregnancy or lactating women. * suspected coagulopathy. * morbid obesity. * known allergy to study medications. * septicemia and local infection at the block site.
hrt versus mos for endometrial preparation prior to fet in pcos patients

Conditions: Infertility; Polycystic Ovarian Syndrome

Summary: evaluation of endometrial preparation using either hormonal therapy or ovarian stimulation prior to frozen-thawed embryo transfer (fet) in patients with polycystic ovarian syndrome (pcos)

women will be randomly divided into two groups; one will be subjected to endometrial preparation by hormone replacement therapy (hrt) and the other will be subjected to minimal ovarian stimulation (mos). women in the hrt group will be given estradiol valerate 4 mg daily from day 2 to day 12 of the cycle then the endometrial thickness will be assessed on day 13 by transvaginal sonography (tvs). if the endometrium is ≥ 8 mm and of moderate echogenicity, luteal phase support (using progesterone supplements) will be started but if the endometrium is \ 18 mm in diameter followed by luteal phase support (using progesterone supplements) after 48 hours. in both groups, fet will be planned in the appropriate day according to the stage that the embryos have been cryopreserved in it.

Eligibility criteria:
inclusion criteria: * women with pcos as defined by the rotterdam criteria. * presence of at least 2 cryopreserved good quality cleavage-stage embryo (good quality cleavage-stage embryos display stage-specific cell division, have blastomeres of fairly equal size with few to no cytoplasmic fragments). exclusion criteria: * moderate or severe endometriosis. * hydrosalpinx. * uterine abnormalities or myoma. * previous uterine surgery.

Keywords: frozen-thawed embryo transfer fet protocols
effect of airway integrated nasal packing with different material

Conditions: Postoperative Respiratory Complications; Pain, Postoperative.

Summary: the purpose of this study is to determine the effect of integrated airway in nasal packing material foe patients receiving nasal septoplasty surgery.

nasal packing with integrated airway had been claimed to improve body oxygenation following septal surgery. this randomized control study examined the effect of airway integrated with nasal packing, in terms of its improvement on oxygen saturation. sixty patients with septal deviation and hypertrophic turbinate were randomized into three groups. group 1 patients were packed with only nasopore@ after surgery. nasopore@ with integrated airway was used for group 2 patients; and vaseline gauze integrated with airway for group 3 patients. hemodynamic parameters were sequentially checked. nasal pain sensation was recorded using visual analog scale.

Eligibility criteria:
inclusion criteria: * patients who underwent septoplasty for septal deviation and chronic hypertrophic rhinitis exclusion criteria: * patients with comorbidities of coronary heart disease, arrhythmia, chronic obstructive lung diseases, and with past history of any nasal surgery were excluded.

Keywords: nasal packing nasal airway septoplasty oxygen saturation postoperative pain
guided antiplatelet therapy in interventional treatment of intracranial aneurysms

Conditions: Intracranial Aneurysm

Summary: the use of intracranial stents expands the possibilities for endovascular treatment of intracranial aneurysms and improves the success rate. however, it also increases the risk of ischemic complications in patients. the current standard dual antiplatelet regimen is considered crucial in reducing thrombotic events. nevertheless, some patients exhibit resistance to antiplatelet drugs, which puts them at a higher risk of thrombotic events. in clinical practice, there is a lack of standardized platelet function testing and consensus on adjusting antiplatelet drug programs. this study conducted a multi-center, prospective cluster randomized controlled trial to investigate whether antiplatelet adjustment therapy guided by light transmittance aggregometry (lta) detection can decrease the occurrence of ischemic events after stent implantation in patients with unruptured intracranial aneurysms. additionally, the study aimed to establish a set of standardized antiplatelet regimens.


Eligibility criteria:
inclusion criteria: 1. patients with unruptured intracranial aneurysms who received intracranial stenting, 2. standard dualantiplatelet therapy for at least 5 days before stent implantation, 3. patients aged 18-80, 4. on the day of registration patients with a modified rankin scale lower than 2, 5. patients who agree and sign the consent form. exclusion criteria: 1. patients with recurrent aneurysms after interventional therapy or clipping therapy, 2. patients with a history of allergy to aspirin, clopidogrel or ticagrelor, 3. patients who used tirofiban prophylactically before surgery, 4. possible active bleeding patients with high blood pressure, such as symptomatic intracranial hemorrhage or active gastric ulcer; or patients with bleeding tendency or coagulation dysfunction, 5. any abnormal platelet count (normal value is 100-300 × 10\^9/l), 6. patients using anticoagulants, 7. pregnant or lactating women, 8. suffering from liver disease, kidney disease, congestive heart failure, malignant tumors and other malignant diseases.

Keywords: intracranial aneurysm interventional therapy stent platelet ischemic stroke bleeding event
post-traumatic arthritis associated with joint injury

Conditions: Arthritis

Summary: arthritis is the nation's most common cause of disability. an estimated 50 million u.s. adults (about 1 in 5) report doctor-diagnosed arthritis. twenty three million u.s. adults of working age (18-64 years) have arthritis; and in this age group arthritis-attributable work limitations affect about 1 in 3 people. an estimated 12% of all patients seeking intervention for symptomatic arthritis have an etiology of previous trauma to the involved joint. the purpose of this study is to examine these inflammatory compounds in the joint fluid (synovial fluid), the joint lining (synovium), and in blood among subjects with isolated intra-articular fractures. the hypothesis is that early levels of intra-articular inflammation and markers of joint tissue degeneration following articular fracture in the human knee are predictive of the development of pta (post traumatic arthritis). early levels of intra-articular inflammation and markers of joint tissue degeneration identified from human knee joints following articular injury are predictive of the development of pta in the mouse knee. samples of blood, urine and synovial fluid will be taken at the spanning frame surgery and only synovial fluid at the orif (open reduction internal fixation)surgery. two mris (magnetic resonance imaging) will be part of this study at 4 weeks and 18 months.participants will complete a set of questionnaires(koos: knee injury and osteoarthritis outcome score) at 4 weeks and 18 months.

40 patients with a closed unilateral articular fracture of the knee requiring operative treatment will be enrolled over an 18 month period. tissue samples including synovial fluid from the injured and contralateral knee, serum and urine will be collected pre-operatively at the time of framing and orif. if patients only need to have one surgery (orif) sample will be collected only once. mri imaging of the injured knee will be obtained after fixation at between week 6 and 8 and at 18 months. tissue samples will be analyzed for established biomarkers of joint inflammation and degradation. patients will be followed for 18 months to assess for signs of post-traumatic arthritis. imaging with plain film and mri will occur at 18 months. mri imaging analysis of cartilage thickness and composition changes will be assessed in the injured knees. assessment of articular cartilage and joint space narrowing and koos will be correlated to biomarkers that may be indicative and predictive of joint degeneration and the development of pta.

Eligibility criteria:
inclusion criteria: * subjects will be adult patients (over 18 years old) * patients must present with a unilateral closed intra-articular fracture of the knee. exclusion criteria: * pre-existing arthritis in the injured or contra-lateral knee, * previous total knee replacement * active joint infection * pathologic fracture * active inflammatory arthritis * open fracture of the involved knee * contra-lateral knee injury * hiv infection (if previously known)
optical coherence tomography (oct) intravascular ultrasound (ivus) dual imaging

Conditions: Coronary Artery Disease (CAD)

Summary: both intravascular ultrasound (ivus) and optical coherence tomography (oct) are standardly used and have been extensively studied separately to guide percutaneous coronary intervention and improve long-term outcomes. in this study, the investigators aim to directly compare high-definition ivus images to oct in the same patients to determine the differences between each modality as they relate to imaging coronary pathology, with the goal of determining which modality is most appropriate in particular clinical scenarios.

intravascular ultrasound (ivus) is an imaging modality that uses ultrasound waves to allow for detailed evaluation of coronary atherosclerotic plaques and the vascular response to coronary interventional devices to guide stent placement during percutaneous coronary intervention. current conventional ivus catheters emit ultrasound waves ranging from 20-40 megahertz (mhz), and more recently released high-definition ivus catheters emit sound waves at 60 mhz, allowing for better image quality, quantitative accuracy, and precision in measurements. optical coherence tomography (oct) is an alternative imaging modality used for similar purposes as ivus, using a single optical fiber that emits infrared light to image the coronary artery. oct uses light in the infrared spectrum with a central wavelength between 1,250 and 1,350 nm. axial resolution with oct is 10-20 microns, whereas it is typically 100-200 microns with ivus. thus, oct allows for better image resolution, but this comes at the expense of tissue penetration.

Eligibility criteria:
inclusion criteria: * undergone diagnostic coronary angiography * evidence of coronary pathology that requires further imaging to guide treatment exclusion criteria: significant renal insufficiency

Keywords: intravascular ultrasound optical coherence tomography
the effect of acupressure on menopausal symptoms

Conditions: Menopause; Acupressure

Summary: this is a prospective, randomized, placebo-controlled and single-blind study planned to determine the effect of acupressure application on menopausal symptoms. the hypothesis of the study is that acupressure reduces women's menopausal symptoms.

menopause is a physiological process during which most women have difficulties and face many problems. acupressure can be taught and used safely as an effective method to manage the symptoms that women experience during menopause. this study aims to determine the effect of acupressure on menopausal symptoms. the study has a prospective, randomized, sham-controlled, single-blind design. the research was conducted with 81 women (acupressure n=40, sham acupressure n=41) attending the "menopause school" in a public hospital in türkiye between july 05, 2021 and august 02, 2021. both groups received acupressure application thrice a week for four weeks, 12 sessions in total. the data was obtained using a personal information form and a menopause rating scale.

Eligibility criteria:
inclusion criteria: * able to speak and understand turkish * no psychiatric illness * natural menopause * not on hormone replacement therapy * women who volunteered to participate in the study and did not receive any integrated therapy were included. exclusion criteria: * those who have undergone menopause with the surgical method * for lower extremity vascular disease, fracture, sprain or injury, diabetes, cardiovascular disease, thyroid disease, etc. with a diagnosis * women who received any integrative therapy were not included in the study.

Keywords: menopause acupressure menopausal symptoms
evaluation of treatment of fractures of the humerus with a plate.

Conditions: Fracture

Summary: the purpose of this study is to study with the use of clinical and radiological parameters the treatment of three-part and four-part fractures with the winsta ph osteosynthesis device (fischer medical).

we shall measure the following clinical parameters with the help of the constant shoulder score (css) and western ontario osteoarthritis of the shoulder index (woos): 1. pain 2. activities of daily living (adl) 3. range of motion (rom) 4. muscle strength we shall measure the following radiologic parameters: 1. healing (migration) of tuberculum majus and minus measured with use of mb-rsa 2. plate migration with use of mb-rsa 3. bone density in the proximal humerus measured with dual energy x-ray absorptiometry (dexa) 4. correlation between bone density and prosthesis migration (and tuberculum migration)

Eligibility criteria:
inclusion criteria: 1. patients with three-part and four-part proximal humeral fractures 2. aged 50 years or older and fit 3. informed, written consent 4. a functioning shoulder preoperatively - exclusion criteria: 1. patients found unsuitable preoperatively for a shoulder philos plate 2. patients aged 85 or older 3. patients with rheumatoid arthritis 4. patients who previously had undergone shoulder plastic or other major shoulder surgery 5. patients unable to avoid nsaid after surgery 6. patients requiring regular systemic steroid treatment 7. female patients taking hormone substitution 8. female patients in the fertile age range who do not use safe anti-conception (oral contraception, intrauterine devices, depot gestagens, vaginal hormone rings) 9. patients with metabolic bone disease -

Keywords: fracture shoulder bone density healing
investigate the effect of azd1656 on the pharmacokinetics of sitagliptin in patients with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to evaluate the effects of azd1656 on sitagliptin pharmacokinetics and vice versa in patients with type 2 diabetes mellitus.


Eligibility criteria:
inclusion criteria: * patients with confirmed type 2 diabetes mellitus for at least 2 months and treated with metformin. * body mass index between ≥19 and ≤42 kg/m2. exclusion criteria: * intake of another investigational drug within the last 30 days prior to enrolment. * clinically significant illness or clinically relevant trauma.

Keywords: type 2 diabetes mellitus, sitagliptin
biomarker research for personalized medicine

Conditions: Hematologic Neoplasms

Summary: the aim of this study : 1. through the study of genes of protein, transporter, translator and epigenome investigating the effect of anti-cancer treatment or the key factor of the mdr (multidrug resistance) on the blood cancer patients who are under the anti-cancer sork treatment 2. giving a service of anticancer medicine therapeutic drug monitoring (tdm) and genotyping


Eligibility criteria:
inclusion criteria: * korean * clinical diagnosis of hematologic neoplasms
a study to learn about the effects of pneumococcal vaccine in people with hiv

Conditions: HIV; Pneumonia; Infections, Pneumococcal

Summary: the purpose of this study is to learn about how well a vaccine (prevnar 13, pcv13) works in preventing disease in adults with hiv. the diseases studied are pneumonia. mostly the ones caused by the bacteria - pneumococcus. this study also evaluates the type of pneumonia that is spread into the bloodstream. all participants in the study will be identified in health care databases. adults with hiv will be identified by looking for a medical diagnosis that has confirmed hiv from the databases. vaccination will be identified in the databases by looking for vaccine administration or for pcv13. participants will be followed in the databases to see if they have one of the diseases mentioned above or not. the number of vaccinated participants with the diseases will be compared to the number participants without the vaccines but with the diseases. this will help to understand how well the vaccine worked.


Eligibility criteria:
inclusion criteria: 1. hiv infection defined as at least one inpatient or ≥2 outpatient codes related to hiv at least 30 days but no more than 730 days apart 2. at least 18 years of age at the time of the first hiv-related code 3. at least six months of continuous enrollment in medical and pharmacy plans after the first hiv-related code exclusion criteria: 1. evidence of pcv13 vaccination before the first hiv-related code