Kornimate/medical-research-clean huggingface dataset:
treating depression with physical exercise

Conditions: Depression

Summary: the purpose of the study is to investigate the effects of an internet-administered, therapist-assisted physical exercise program for the treatment of depression.

previous research has found promising results regarding physical exercise as treatment of depression. this study will test a 9 week, internet-administered, therapist-assisted physical exercise program.

Eligibility criteria:
inclusion criteria: * satisfy dsm-iv criteria for depression * living in sweden and being able to read swedish * access to computer with internet connection exclusion criteria: * currently receiving other psychological treatment * non-stable use of psychoactive medication * deemed to suffer from a too severe depression, or being suicidal * deemed to suffer from other psychological disorder, e.g. psychosis, bipolarity etc.

Keywords: depression physical exercise internet
application of 68ga-labeled ace2 targeting probe pet/ct imaging in tracing ace2 expression and diagnosis of lung cancer

Conditions: Lung Cancer; Healthy Human

Summary: in the past three years, as the key protein suggested to be involved in host cell entry of sars-cov-2, studies of ace2 aroused people's attention again. tracking the expression of ace2 in vivo is crucial to further understanding of covid-19, dynamically monitoring the effect of antiviral therapy and the development of related vaccines. it is also expected to further conduct in-depth research on the physiological effects of ace2 and raas, and the mechanism of acei/arb (32). with the development of both molecular imaging agents and related equipment, several ace2-targeting pet imaging agents have been investigated based on different strategies while some of them were tested in clinical trials. the aim of this study was to intercept key ace2-binding sites from coronavirus rbd and test their potential as ace2-targeting pet agents.


Eligibility criteria:
inclusion criteria: * the ability to provide informed written consent * a medical history without any ace2-related comorbidities exclusion criteria: * liver and renal function dysfunction, * pregnancy or current lactation
dm1 heart registry - dm1 respiratory registry

Conditions: Myotonic Dystrophy

Summary: myotonic dystrophy type 1 (dm1) is the most frequent neuromuscular disease in adults. dm1 patients have an impaired prognosis (mean age of death \<60 years) due to cardiac and respiratory complications. our primary objective was to identify cardiac and respiratory prognostic factors in dm1.

1. patients with genetically proven dm1 who were admitted in pitié salpêtrière hospital from 2000 and 2010 will be identified. these patients systematically underwent neurological, cardiac and respiratory investigations. 2. baseline medical and genetic information will be entered in a dedicated database, including cardiac and respiratory investigations. 3. the occurence of severe cardiac and respiratory adverse events will also be collected. 4. statistical analysis will be performed to look for correlations between baseline patient characteristics and cardiac or respiratory adverse events during follow up.

Eligibility criteria:
inclusion criteria: * dm1 mutation (\>50 ctg repeats) * age \> 18 years exclusion criteria: * patient refusal

Keywords: myotonic dystrophy prognosis sudden death respiratory failure
provoxlife adoption trends for heat-moisture exchanger

Conditions: Malignant Head and Neck Neoplasm

Summary: this study examines factors that affect how often patients who have a total laryngectomy use a provoxlife heat-moisture exchanger (hme) system to help improve their lung function. provoxlife hmes are single use heat- and moisture exchangers for patients breathing through a tracheostoma. information from this study may help doctors learn more about factors associated with patterns of use and how often patients use the provoxlife hme system.

primary objective: i. to determine clinical and patient factors associated with patterns of use of the provoxlife hme system for pulmonary rehabilitation after total laryngectomy. secondary objectives: i. to explore outcomes associated with patterns of provoxlife hme system. ii. to explore factors associated with post-laryngectomy outcomes. outline: patients undergo speech and swallow evaluation by speech pathologist or study staff member and examination of tracheoesophageal puncture (tep) and laryngectomy stoma. patients also complete questionnaires over 30 minutes about use the provoxlife hme system, symptoms, ability to communicate, exercise and physical activity levels, and quality of life at baseline and 3 months post-provoxlife.

Eligibility criteria:
inclusion criteria: * adults \>= 18 years of age planned for or status post total laryngectomy * using or ready for fit of hme system exclusion criteria: * active malignancy if post-total laryngectomy (tl) at the time of enrollment * unable to complete questionnaires in english language * the primary endpoint derives from a study specific questionnaire, due to limited resources, is only available in english language * cognitive or other limitations that preclude independent self-care or completion of questionnaires * cognitive or other limitations that preclude independent self-care or completion of questionnaires will be assessed in the screening interview by the clinical or research team
a study to evaluate and study drug levels in blood plasma when giving high doses of gsk189075 to healthy volunteers

Conditions: Type 2 Diabetes Mellitus; Diabetes Mellitus, Type 2

Summary: this study will assess safety and tolerability when taking gsk189075 at doses that are likely to be higher than the expected prescribed doses. the study will also measure the level of gsk189075 in blood after dosing as well as the effect of the drug on certain laboratory tests performed on volunteer urine and blood. each volunteer will take part in 3 dosing periods and will be given a different dose level at each period (either 2000mg, 4000mg, or a placebo). volunteers will not know which of the three doses they are receiving. in each period, volunteers will dose every morning for three straight days. before and after dosing, blood pressure, heart rate, laboratory tests on blood and urine, physical examinations and ecgs will be taken to assess safety. volunteers will also be asked to provide information should they feel they are having a possible effect from the gsk189075. the levels of gsk189075 in the blood will be assessed by multiple blood draws, most of these will follow the third dose in each period. depending on the results from the preceding periods, a fourth period may be added to the study to assess another dose level. the fourth period, if this is to occur, will be the same design as the other three periods, and the dose received will be less than 4000mg.


Eligibility criteria:
inclusion criteria: * healthy males and non-pregnant females as determined by a physician on the basis of medical history (including family history of heart disease), physical examination, and clinical laboratory tests. * written consent given * agreement to follow specific requirements of birth control during participation. exclusion criteria: * history of drug or alcohol abuse within one year of the study screening. * use of tobacco or nicotine-containing products with 6 months prior to the study screening. * use of any prescription or non-prescription drugs, vitamins, herbal, and dietary supplements within 14 days of the start of the study. * blood donation within 56 days before the start of the study * receiving other investigational drugs or participating in other research trials within 30 days of the start of this study.

Keywords: dose escalation; supratherapeutic; gsk189075; diabetes
caffeine and neurologic recovery following surgery and general anesthesia

Conditions: Pain, Postoperative

Summary: the ongoing opioid epidemic is a public health crisis, and surgical patients are particularly vulnerable to opioid-dependency and related risks. emerging data suggest that caffeine may reduce pain after surgery. thus, the purpose of this study is to test whether caffeine reduces pain and opioid requirements after surgery. the investigators will also test whether caffeine improves mood and brain function (e.g., learning, memory) after surgery.

opioid-related deaths have quadrupled in the last 20 years, and nearly half of these deaths currently involve prescription opioids. surgical patients often experience moderate-to-severe pain is common after major surgery, and surgery is associated with a 14-fold increased risk of opioid dependency compared to non-surgical controls, even after minor surgery. furthermore, mood disorders (e.g., depression) are independently associated with persistent opioid use postoperatively, and signs of postoperative depression are common after major surgery. thus, given these risk factors, surgical patients are at particularly high risk for opioid dependency postoperatively. interventions that (1) reduce opioid burden, and (2) improve mood and neuropsychological function may mitigate the risk of postoperative opioid dependency. preliminary laboratory and clinical findings demonstrate that caffeine may reduce pain after surgery, which may translate to lower opioid requirements. the study tests the hypothesis that intraoperative caffeine administration will improve opioid consumption, pain, and neuropsychological recovery in patients undergoing surgery. through validated assessment measures, the research team will study the effects of caffeine in relation to postoperative opioid requirements, pain, and neuropsychological (e.g., cognition, depression, anxiety) trajectory after surgery.

Eligibility criteria:
inclusion criteria: * adult (\>/= 18 years old) undergoing non-cardiac, non-neurologic, non-major vascular surgery requiring general anesthesia exclusion criteria: * emergency surgery * cognitive impairment precluding capacity for informed consent * uncontrolled cardiac arrhythmias * seizure disorders * preoperative opioid use * diabetes * liver failure * pregnancy * breastfeeding * severe visual or auditory impairment (may hinder cognitive function testing) * patients unable to speak english.

Keywords: opioid use opioid dependence opioid-related disorders opioid abuse opioid-use disorder pain pain, postoperative cognitive impairment delirium delirium on emergence depression anxiety anxiety disorders affect
steroids and/ or non-steroidal anti-inflammatory drugs in the postoperative regime after trabeculectomy.

Conditions: Glaucoma

Summary: purpose: glaucoma is the leading cause of non-curable blindness globally. patients with glaucoma will get a gradual narrowing of the visual fields caused by compression at the optic nerve head due to increased intraocular pressure. thus the main preventive strategy is to reduce intraocular pressure, initially by eye drops and/or laser treatment but in some patients surgery is warranted. the surgical procedure (trabeculectomy) most widely performed worldwide creates a path from the anterior chamber to the subconjunctival space and thereby lowers the iop by producing a more efficient drainage of the aqueous humour. surgical success depends upon controlling post-operative inflammation to ensure a functional drainage. the purpose of this blinded, randomized study is to investigate which anti-inflammatory treatment provides better long-term control of intra-ocular pressure (iop) following glaucoma surgery (trabeculectomy) by comparing topical nsaids to topical steroids. additionally, we want to explore the mechanisms behind the pathophysiology of glaucoma by evaluating retinal and optic nerve head perfusion before and after iop lowering surgery. the primary outcome is the intraocular pressure 12 months after surgery measured by applanation tonometry. main hypothesis: * nsaids and steroids are equally effective in assuring long-term filtering function and controlling iop after trabeculectomy but may be associated with different risk profiles and bleb morphology * patients with lower post-operative iop demonstrate less progression of visual field loss * trabeculectomy lowers iop and provides better microcirculation in and oxygenation of inner retinal layers (i.e. ganglion cell layer) and the optic nerve head


Eligibility criteria:
inclusion criteria: * patients with primary open-angle glaucoma (poag), pseudoexfoliation syndrome (pex), pigment dispersion syndrome (pds) or ocular hypertension * \>50 years * women must be postmenopausal. women are asked if they have menstruated within the preceding 12 months * scheduled to undergo trabeculectomy surgery at the department of ophthalmology at rigshospitalet-glostrup, denmark * informed consent to participation and ability to comply with study procedures exclusion criteria: * known allergy to any of the contents of the pharmaceuticals (active and in-active ingredients) used in the study * prior intraocular surgery, except from cataract surgery. if cataract surgery has been performed, it should at least be 6 months prior to surgery * medical history of anterior segment dysgenesis, inflammatory/uveitic glaucoma, angle closure glaucoma, neovascular glaucoma and traumatic glaucoma * steroid responders * pregnancy * fertile women, i.e. women who are not menopausal and women who breastfeed * patients in systemic treatment with steroid or nsaid

Keywords: trabeculectomy nsaid steroid anti-inflammatory agents anti-inflammatory agents, non-steroidal eye diseases
direct versus us guided pecs block on controlling postmastectomy pain

Conditions: Postmastectomy Pain

Summary: perioperative analgesia for surgery in carcinoma breast utilizes significant quantities of opioids as compared to cosmetic breast surgeries. regional anesthesia reduces the need for perioperative opioids and thus may improve the outcome. the investigators decided to perform the modified pectoral nerve block ( pec ii) under vision after resection of tumor, without ultrasound and compare the postoperative analgesic and opioid sparing effects of the nerve block with ultrasound guided modified pectoral nerve block (pec) in patients undergoing modified radical mastectomy.


Eligibility criteria:
inclusion criteria: * 20 - 50 years * asa i or ii undergo elective simple mastectomy exclusion criteria: * patients with diabetes mellitus i * intradialytic hypotension, * chronic kidney disease and bronchial asthma

Keywords: ultrasound guided pecs block direct pecs
surveillance of suspected dengue cases for access to care for subjects identified as seronegative or undetermined before receiving cyd dengue vaccine in previous clinical studies in colombia

Conditions: Dengue Fever

Summary: the primary objective of the study is to identify any suspected dengue case in subjects that received at least one dose of the cyd dengue vaccine who were classified as seronegative or undetermined at baseline (according to prnt50 at baseline, or anti-non-structural protein 1 \[ns1\] test post-dose 3) in the colombian study sites of cyd15, cyd13, cyd29, cyd64, cyd65 trials in order to allow appropriate access to care until the completion of 10 years after the last cyd dengue vaccine received by each participant

the planned duration of each participant's participation in the study will vary according to the date when they received their last cyd dengue vaccine. the surveillance will last during 10 year after the last cyd dengue vaccination of included participants

Eligibility criteria:
inclusion criteria: * participants classified as seronegative or undetermined at baseline (by prnt50 at baseline or anti-ns1 test post-dose 3) that had received at least one dose of the tetravalent cyd dengue vaccine in the clinical sites of cyd15, cyd13, cyd29, cyd64, or cyd65 studies in colombia * informed consent form or assent form has been signed and dated by the participant (based on local regulations), and/or informed consent form has been signed and dated by the parent(s) or another legally acceptable representative (and by an independent witness if required by local regulations) * participant (or participant and parent\[s\] or another legally acceptable representative) is (are) able to comply with all study procedures exclusion criteria: * participants that were withdrawn from the cyd15, cyd13, cyd29, cyd64, or cyd65 study in colombia study due to "lost to follow-up" and despite various attempts, were not possible to be contacted * participants that cannot be contacted after 3 phone calls, sms, one home visit and written contact letter/email/whatsapp the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
optimal measurement of spleen stiffness among veterans with metabolic dysfunction-associated steatotic liver disease

Conditions: Metabolic-dysfunction-associated Fatty Liver Disease (MAFLD)

Summary: a growing number of people are being diagnosed with fatty liver disease, also known as metabolic-dysfunction associated liver disease (masld). fatty liver disease can unknowingly progress to serious liver disease and even permanent scarring (cirrhosis).the purpose of this research is to learn the best way to detect serious liver disease as early as possible in patients with fatty liver disease by measuring the stiffness of the spleen. secondarily, the study hopes to understand how the stiffness of the spleen relates to the severity of liver disease.


Eligibility criteria:
inclusion criteria: * able to consent for participation in a clinical study * able to read and comprehend english * evidence of fatty liver disease on previous liver biopsy, imaging or clinical documentation exclusion criteria: * pregnant * known decompensated cirrhosis or hepatocellular carcinoma * absence of spleen * documentation of alcohol use disorder or alcohol use greater than 20g/day for women or greater than 30 g/day for men * unable to provide informed consent
prevalence of pancreatic anomalies of patients with a 1st degree familial history of pancreatic adenocarcinoma

Conditions: Prevalence of Pancreas Adenocarcinomas

Summary: pancreatic adenocarcinoma is the 4th leading cause of cancer in the usa. its incidence is increasing both in france and in europe, whereas all the other cancers are decreasing in europe. moreover, its seriousness is still high, with a mortality rate higher than the average incidence. the aim of papafa study is to assess the prevalence of the pancreatic anomalies which can be revealed thanks to imaging, for patients having a 1st degree pancreatic adenocarcinoma familial history. this could allow detection of lesions which are less than 10 mm long, and improve the dark prognostic of this pathology.


Eligibility criteria:
inclusion criteria: * patients with a 1st degree familial history of pancreas adenocarcinoma * patients older than 40 * patients whose life expectancy is \> 3 months * inform and consent form signed * patient insured under the french social security system exclusion criteria: * contraindication to the mri (pace-maker, implanted metallic material, medical history of allergy to the contrast agent, end-stage renal failure, pregnancy, claustrophobia) * contraindication to anesthesia to do the echo endoscopy * 1st degree family history of 2 pancreas adenocarinomas * medical history of allergy to benzylic alcool * contraindication to dimeglumine gadobenate * pregnant or breastfeeding woman, according to the questioning * subjets who don't have the legal capacity to consent

Keywords: pancreas adenocarcinoma
effect of laser and sclerotic agent in the treatment of oral granuloma

Conditions: Pyogenic Granuloma of Gingiva

Summary: pyogenic granuloma is a common tumor-like growth of the oral cavity considered to be non-neoplastic in nature. they usually present as a reactive lesion occur in response to chronic and recurring tissue injury, in which capillaries are very prominent commonly seen arising from interdental gingiva. pyogenic granuloma may occur in all ages, with a peak age of incidence in the second decade of life, more common in young adult females, possibly because of vascular effects of female hormones.

oral pg can be treated by conservative excision. local irritants or the source of trauma must be eliminated to minimize the risk of recurrence. although, surgical excision is considered a simple procedure, it might be complicated by several complications such as intraoperative bleeding, and postoperative infection that might delay the healing of the wound. other treatment modalities such as laser, injection of sclerosing agents have been used. laser has proven to be an effective therapy for oral soft tissue pathologies. moreover, its ability to perform precise incisions, better hemostasias, and less invasive procedures with less discomfort to patients have made it a preferred treatment option for several soft tissue lesions. sclerotherapy has been proposed as an effective method of treatment for pyogenic granuloma. their mechanism of action is endothelial injury, inflammation, thrombosis, fibrosis, and final lesion destruction. polidocanol is a widely used nonionic detergent sclerosant that was first developed as an anesthetic. it acts through endothelial overhydration, vascular injury, and closure.

Eligibility criteria:
inclusion criteria: * all the subjects were principally diagnosed based on history and clinical features such as oral pyogenic granuloma are selected for this study. radiographic evaluation was also done to rule out any bony involvement. * the sizes of participants' lesions were not less than 5 mm. • age \> 18 years exclusion criteria: * patients were excluded if they had uncontrolled diabetes, renal diseases, coagulation disorders or were allergic to any of the sclerosing drug constituents. immune-compromised patients and pregnant and lactating women were also excluded from the study.

Keywords: pyogenic granuloma laser therapy sclerosing agent
the effects on pain of acupressure and foot reflexology before heel lancing in newborns

Conditions: Interventions Pain

Summary: this study aimed to determine the effects of foot reflexology and acupressure on the ki3 and st36 points on pain during interventions when these procedures were administered before heel lancing in term newborns.


Eligibility criteria:
inclusion criteria: 1. being born by cesarean section, 2. being a term newborn, 3. being completed the 24th hour of the postnatal period, 4. staying with birth mother, 5. being fed in the last half hour before the procedure, 6. having a heel prick performed by the same nurse, 7. giving blood on the first try (because pain level may change on the second try), 8. having a mother who gave written informed consent exclusion criteria: 1. having no health problem, 2. being underwent more than 2 invasive interventions, 3. receiving an analgesic/sedative drug in the 8 hours before the application.

Keywords: newborn, pain, heel lance, foot reflexology, acupressure, nurse