Kornimate/medical-research-clean huggingface dataset:
a pilot study to assess efficacy and safety of pardoprunox as adjunct therapy to l-dopa in the treatment of patients with parkinson's disease experiencing motor fluctuations and dyskinesia.

Conditions: Advanced Stage Parkinson's Disease

Summary: this is a multicenter, randomized, double blind, pramipexole-controlled parallel group study of pardoprunox as adjunctive treatment to levodopa.

approximately 44 patients are to be randomized in a 3:1 ratio to two possible treatment groups, pardoprunox and pramipexole, respectively. the first part of the study will be blinded and consists of a minimum 1-week screening period, a 4-week switch and stabilization period and an 8-week maintenance period. the second part of the study will be open label pardoprunox treatment with a dose adjustment period of 4 weeks followed by long term maintenance treatment.

Eligibility criteria:
inclusion criteria * patients who have signed informed consent * diagnosis of idiopathic parkinson's disease * stable treatment with l-dopa and dopamine agonist for at least 28 days prior to randomization * presence of a recognizable on and off state (motor fluctuations) * minimum hours of off-time per day of 1.5 hours (during waking hours including early morning akinesia) as recorded per baseline diaries * minimum hours of on time with troublesome dyskinesia of 2 hours (during waking hours) as recorded per baseline diaries * prevalent expression of severely disabling dyskinesias during the waking day, i.e. dyskinesias are present at least 25% of the waking hours (updrs part 4 item 32 \>= 2) in combination with a degree of disability which is moderate or higher (updrs part 4 item 33 \>=2) exclusion criteria * diagnosis is unclear or a suspicion of other parkinsonian syndromes * patients who have undergone surgery for the treatment of pd

Keywords: parkinson's disease
investigation of the transfusion practices in surgical patients in turkey

Conditions: Surgery; Blood Loss, Surgical; Blood Loss Anemia; Blood Transfusion; Anemia; Coagulation Disorder

Summary: the aim of this study is to describe the transfusion practices in patients undergoing major surgery in turkey. the transfusion rates of red blood cells (rbc), fresh frozen plasma (ffp) and platelets; the transfusion predictors and transfusion related patient outcomes are investigated.

patient blood management (pbm) is an evidence based multidisciplinary approach for the care of patients who may need blood transfusion. the aim of pbm is achieving better patient outcomes by focusing on the patients' own blood as a source. to date pbm is considered "good transfusion practice" and is being implemented in a growing number of countries. the turkish society of anesthesiologists pbm task force is working on this subject since 4 years and decided to conduct a study. before starting a pbm program, the transfusion practices of clinicians working at diverse surgical fields; differences between current transfusion practices and pbm strategies; the areas for improvement and the obstacles that could prevent change could be identified with this study. data collection will also serve to identify the current situation as a reference and to control the achievement of the pbm's aim: improving clinical outcomes. these data will be refered as the turkish national perioperative transfusion study (tulip ts) data. the aim of this study is to describe the transfusion practices in patients undergoing major surgery in turkey. the study evaluates i. the perioperative transfusion rates of rbcs, ffp and platelets. ii. with which reasons the anesthesiologists decide to transfuse a patient (co morbidities of the patients, physiologic transfusion triggers, hemoglobin trigger, uncontrolled bleeding, on request from surgeon etc.). iii. the relation of transfusion and the patients co-morbidity index, the p possum score and sort score; anesthesia methods; monitorisation methods (hemodynamic, coagulation); amount of bleeding; type of surgery; type of hospital. iv. the relation of transfusion and patient outcomes (unanticipated icu admission, prolonged icu stay, acute renal failure, thromboembolic events, ischemic events, pulmonary complications, cardiac advers events, infections, acute respiratory distress, infection, all-cause mortality).

Eligibility criteria:
inclusion criteria: patients undergoing major elective surgery exclusion criteria: trauma patients, emergency surgery
study about annoucement of the diagnosis of neurofibromatosis 1 in de novo forms

Conditions: Neurofibromatosis 1; Diagnoses Disease; Post Traumatic Stress Disorder

Summary: neurofibromatosis type 1 (nf1) is one of the most common autosomal dominant genetic disorders. the aim of our study was to evaluate post-traumatic stress disorder (ptsd) in patients and their families following the disclosure of sporadic nf1. diagnosis of nf1 was retained according to nih criteria, familial forms were excluded. the french version of the impact of event scale-revised was used for the diagnosis of ptsd.


Eligibility criteria:
inclusion criteria: * patient aged 18 or more, or parent of a children * patient with a neurofibromatosis type 1 or parent of a children with a neurofibromatosis 1 in de novo form * followed for a neurofibromatosis type 1 de novo at the dedicated consultation in the university hospital of brest, since april 2013 * agree to participate exclusion criteria: * patients aged of 18 years old or lower * refusal to participate
a study of thymoglobulin and tacrolimus in liver transplant

Conditions: Liver Transplantation; Liver Disease; Immunosuppression

Summary: the purpose of this study is to compare kidney function, long term patient and graft survival, and incidence of acute rejection in liver transplant recipients between one group receiving thymoglobulin induction and delayed initiation of tacrolimus and another group of liver transplant recipients having immediate administration of tacrolimus without any induction immunosuppression.

renal insufficiency following liver transplantation in adult recipients is a major cause of morbidity and a major contributor to mortality. one of the key factors contributing to this renal dysfunction is the use of calcineurin inhibitors. there is some evidence to suggest that the first 7-10 days following liver transplantation are crucial in terms of renal function and the ability to avoid the use of nephrotoxic agents such as calcineurin inhibitors may have a significant impact on long-term outcome.

Eligibility criteria:
inclusion criteria: * primary liver transplant recipient with model for end stage liver disease (meld) criteria documentation * over 18 years of age * signed informed consent form * if female of childbearing potential: must not be lactating must have negative serum pregnancy test on study day 0 must have agreed on a reliable and acceptable form of contraception during the study * sexually active males must be practicing an acceptable form of contraception exclusion criteria: * multiple organ transplants * prior solid organ or bone marrow transplant recipients * fulminant hepatic failure * status 1 transplants * liver transplant candidates with greater than 6 weeks of dialysis * patients who in the opinion of the investigator are not eligible for thymo induction at the time of transplant * recipients of investigational therapy within 90 days prior to transplant * know contraindication to administration of rabbit anti-thymocyte globulin * patients whose medical condition is such that the physician feels it would not be in their best interest to participate in the study * patients who are unwilling to have a glofil nuclear medicine scan at specified time points * history of malignancy within 5 years with the exception of: * adequately treated localized squamous or basal cell carcinoma of the skin without evidence of recurrence, and /or * hepatocellular carcinoma

Keywords: liver transplant
external oblique intercostal plane block versus transversus abdominis plane block for postoperative analgesia in adult patients undergoing open nephrectomy

Conditions: External Oblique Intercostal Plane Block; Transversus Abdominis Plane Block; Postoperative Analgesia; Nephrectomy

Summary: the aim of this study is to compare external oblique intercostal plane (eoip) block and ultrasound guided transversus abdominis plane (tap) block for postoperative analgesia in adult patients undergoing open nephrectomy.

patients undergoing nephrectomy have a high incidence of postoperative pain despite the use of modern laparoscopic surgical techniques. in the postoperative period, these patients are often treated with patient-controlled opioids, epidural analgesia, or both. ultrasound-guided transversus abdominis plane (tap) block is a relatively new technique to infiltrate regional anesthesia in which local routine anesthetics are injected between the internal oblique and transverse abdominal muscles. studies have confirmed that ultrasound-guided (usg) transversus abdominis plane (tap) block is an effective method of analgesia for upper abdominal surgeries, lower abdominal surgeries, and kidney transplantation, with minimal side effects. external oblique intercostal plane block (eoipb) has been reported by elsharkawy et al. in 2021 as a significant modification of fascial plane blocks in that it may engage the upper lateral abdominal walls consistently. in comparison to quadratus lumborum block (qlb) and erector spinae plane block (espb) , the advantage of eoipb is that it may be performed with the patient supine. furthermore, in comparison to serratus intercostal plane block (sipb), it generates more extensive analgesic effects throughout the whole midline of the abdomen .

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * both sexes. * american society of anesthesiology (asa) physical status i-ii. * scheduled for open nephrectomy. exclusion criteria: * bleeding disorders. * skin lesions or infection at the site of proposed needle insertion. * allergy to local anesthetics. * neurological disorders. * drug abuse. * bmi \> 30 kg/m2. * pregnancy. * diabetic neuropathy. * severe cardiovascular problems.
hidradenitis suppurativa mail survey

Conditions: Hidradenitis Suppurativa

Summary: hidradenitis suppurativa (hs), also known as "acne inversa," is a chronic dermatologic disease affecting apocrine gland-bearing areas and presenting with symptoms ranging from pustules and inflammatory nodules to draining sinuses, abscesses, and fistulae. the pain and odorous lesions associated with hs contribute to its heightened impact on quality of life in comparison to other diseases; it has been described as "one of the most distressing conditions observed in dermatology." though it is clear that hs has a significant impact on quality of life, how this manifests remains poorly characterized. the aim of this study is to characterize the quality of life impact of hs and to validate a tool for patients to self-assess the severity of their condition.

running a comprehensive study and asking patients what challenges they encounter in their daily lives can shed light on the ways in which hs causes quality of life impairment. in this study, the study team aims to identify the following: problems faced by patients with hs, the rate of depression, the rate of stigmatization, the rate of fear of being accepted in society, treatments that patients have tried (and which treatments seem to have worked best), the rate of alternative treatment use, and the correlation of these factors with the severity of disease.

Eligibility criteria:
inclusion criteria: * patients diagnosed with hidradenitis suppurativa by a dermatologist at wake forest baptist medical center's dermatology clinic. * patients 18 years of age or older exclusion criteria: * patients younger than 18 years of age * any patient who does not have a mailing address on file

Keywords: acne inversa hs verneuil's disease
bacterial growth in vascular surgery wounds

Conditions: Lower Limb Ischaemia; Aneurysm

Summary: the amount and species of bacteria have been shown to have an effect in wound infections in several fields of surgery (such as gastrointestinal and orthopaedic surgery and the surgery of facial area). in vascular surgery, wound infections are a common and expensive complication. the aim of the present study is to investigate the prevalence of bacteria in vascular surgery wounds perioperatively, and determine whether is correlates with the incidence of wound infections postoperatively.


Eligibility criteria:
inclusion criteria: * need for lower limb vascular by-pass surgery exclusion criteria: * allergic to cefuroxime * patients refusal to participate
thick vs. thin acellular dermal matrix (adm)

Conditions: Gingival Recession

Summary: to study and compare a thick vs thin acellular dermal matrix for root coverage using the coronally positioned tunnel technique.


Eligibility criteria:
inclusion criteria: a. at least one miller class i or ii mucogingival defect ≥ 3 mm (miller 1985). b. the mucogingival defect must be on a non-molar tooth. c. patients must be ≥ 18 years of age. exclusion criteria: a. patients with debilitating systemic or diseases that significantly affect the periodontium. b. patients with a known allergy to any of the materials that will be used in the study, including systemic antibiotics (tetracycline and doxycycline). c. patients requiring antibiotic prophylaxis. d. root surface restorations at the site of recession. e. no detectable cej f. patients who fail to maintain acceptable oral hygiene levels at the test and adjacent teeth. g. patients who are pregnant or lactating. h. patients who use tobacco products (smoking or smokeless tobacco). i. patients with alcohol abuse problems. j. patients undergoing long-term steroid therapy. k. history of previous root coverage procedures, graft or gtr, on the test teeth. l. patients who fail to complete the informed consent form.
women's health habits study

Conditions: Risk Drinking,Diabetes, Hypertension, Osteoporosis, Infertility

Summary: the purpose of this randomized trial is to test the effectiveness of screening and brief intervention for risk drinking by nonpregnant women with specific medical problems exacerbated by excessive alcohol consumption. the medical problems are female factor infertility, hypertension, diabetes, and osteoporosis, conditions that are costly to treat and difficult to manage. just as pregnant women are thought to be highly motivated to modify their alcohol consumption, so women with specific medical problems worsened by alcohol intake are an appropriate group to receive a brief intervention.


Eligibility criteria:
inclusion criteria: - 1. has diabetes, hypertension, osteoporosis, or infertility 2. not currently receiving treatment for alcohol or drug problems or substance related medical illness 3. not currently experiencing physical dependence on alcohol, requiring medically supervised detoxification 4. not currently abusing or physically dependent on opiates, cocaine, or other illicit drugs 5. not currently pregnant. subjects with infertility may become pregnant during the course of the study. 6. not currently nursing. 7. able to complete study measures. exclusion criteria: 1. alcohol screen negative or drinks within niaaa sensible drinking limits for women 2. does not agree to randomization and study terms

Keywords: risk drinking women medical problems
body composition in systemic amyloidosis

Conditions: Amyloidosis

Summary: malnutrition is a prominent clinical feature of patients affected by systemic immunoglobulin light-chain amyloidosis (al), with a prevalence ranging between 25-50%. although the prognosis predominantly depend on the presence and severity of cardiac involvement, it was shown that malnutrition is an independent predictor of survival and quality of life. however, the assessment of nutritional status by common indices based on anthropometry is not always feasible and accurate due to reduced performance status and/or the presence of fluid imbalances (for example edema and ascites). several recent studies have demonstrated the prognostic value of the phase angle. moreover, the value is supported by its applicability to patients who are bedridden or present alterations in the state of hydration.


Eligibility criteria:
inclusion criteria: * diagnosis of systemic immunoglobulin light-chain (al) amyloidosis * written informed consent exclusion criteria: * age \<18 years * ongoing artificial nutrition * unavailability to planned measurements
evaluation of bay 59-8862 in taxane resistant non-small cell lung cancer patients

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: lung cancer is among the most common cancers in the world and its incidence continues to increase. chemotherapy for patients with non-small cell lung cancer (nsclc) has been under investigation for several decades and several new drugs with activity in nsclc have been identified. these include the taxanes, which are among the most commonly used class of chemotherapy agents in clinical oncology today. the usefulness of the taxanes is limited by the development of tumor resistance to these agents. this phase ii trial with bay 59-8862 will be conducted to determine the anti-tumor efficacy of bay 59-8862 in taxane-resistant nsclc.


Eligibility criteria:
inclusion criteria: * measurable disease as defined by the presence of at least one measurable lesion * patients must have received at least 3 weeks of continuous therapy with taxane - patient must subsequently develop progressive disease either during treatment or within 6 months after treatment * life expectancy of at least 12 weeks * adequate bone marrow, liver and kidney function exclusion criteria: * excluded medical conditions like: pre-existing neuropathy, active heart diseases or ischemia, serious infections, hiv infection, chronic hepatitis b or c; brain metastasis, seizures, hypersensitivity to taxanes, organ transplants, some previous cancers * excluded therapies and medications, previous and concomitant such as: anticancer chemotherapy or immunotherapy during the study or within 4 weeks prior to study entry; more than two prior anticancer chemotherapy regimens; radiotherapy during study or within 4 weeks prior to study entry; bone marrow transplant. * others: pregnant or breast-feeding patients; both men and women enrolled in this trial must use adequate barrier birth control measures during the course of the trial; substance abuse, medical, psychological or social conditions that may interfere with the patient's participation.

Keywords: taxane lung cancer, non-small cell nsclc
transfusion rates in total hip replacement before/after the implementation of a patient blood management program.

Conditions: Anemia (Diagnosis); Iron-deficiency; Transfusion; Arthroplasty

Summary: retrospective observational study: impact of a peri-operative patient blood management program (pbm) on transfusion rates of patients undergoing elective hip replacement.

a patient blood management (pbm) program was implemented in year 2019 in our institution: patient scheduled for elective total hip replacement underwent pre-operative screening about one month before surgery, and those with pre-operative hemoglobin \< 13 g/dl were screened for possible causes and treatment of anemia. data from two different time frames, before and after the implementation of the program, were collected to study the change in clinical outcomes such as transfusion rates, length of stay, etc.

Eligibility criteria:
inclusion criteria: * undergoing elective hip replacement in the selected time-frame * american society of anesthesiology (asa) status 1-2-3 * age \>18 exclusion criteria: * patients not undergoing screening as outpatients at pre-operative clinic

Keywords: patient blood management anemia arthroplasty
an effectiveness and safety study comparing acetaminophen (3900 mg/day) to ibuprofen (1200 mg/day) in the treatment of post-race muscle soreness.

Conditions: Pain

Summary: the purpose of this study is to compare the effectiveness and safety of acetaminophen extended release caplets and ibuprofen in relieving the muscle soreness that occurs after a marathon.

the objective of this randomized, double-blind study is to compare the effectiveness and safety of acetaminophen extended release caplets and ibuprofen in relieving the muscle soreness that occurs in subjects who complete a marathon. subjects are randomized to receive acetaminophen extended release caplets, 3900 mg/day (two 650 mg caplets taken three times a day, for five days) or ibuprofen caplets, 1200 mg/day (two 200 mg caplets taken three times a day, for five days). the primary measurement of efficacy is the average change in muscle soreness from baseline for both the morning and evening assessments. safety assessments consist of monitoring adverse events, and a physical examination including vital signs, weight, a review of concomitant medications, and a urine pregnancy test for female subjects. two hypotheses are examined in a step-down approach. the first hypothesis is that acetaminophen extended release is not inferior to ibuprofen in relieving the muscle soreness that occurs after a marathon. if acetaminophen extended release is not inferior to ibuprofen in relieving the muscle soreness that occurs after a marathon, the second hypothesis is that acetaminophen extended release (3900 mg/day) is superior to ibuprofen (1200 mg/day) in relieving the muscle soreness that occurs after a marathon. two acetaminophen 650 mg extended release caplets, taken by mouth, three times a day for five days or two ibuprofen 200 mg caplets, taken by mouth, three times a day for five days.

Eligibility criteria:
inclusion criteria: * patients must complete the marathon * be able to swallow the study medication * comply with study requirements regarding the use of any other pain medications before, during or after the marathon * rate their muscle soreness on the evening after the marathon as at least a 4, on a zero-to-ten point scale * if female, must not be pregnant or breastfeeding, and must be using an acceptable form of contraception exclusion criteria: * previous diagnosis of osteoarthritis requiring pain medication therapy * currently have a major medical illness * have a history of cardiovascular disease, heat injury (heat exhaustion or heat stroke) or collapse during a running or endurance event * known hypersensitivity to acetaminophen or ibuprofen

Keywords: muscle soreness pain, acetaminophen ibuprofen