Kornimate/medical-research-clean huggingface dataset:
fluorescent visualization in early oral cancer

Conditions: Oral Squamous Cell Carcinoma or Severe Dysplasia

Summary: studies from vancouver show that fluorescent visualization (fv) is a useful method of controlling surgical margins. this early finding will now be confirmed in a national randomized controlled trial.


Eligibility criteria:
inclusion criteria: * biopsy proven invasive oral cancer or severe dysplasia / cis * invasive cancer must be t1 or t2 * no prior history of oral cancer / treatment of oral cancer exclusion criteria: * prior history of oral cancer * unable to provide informed consent * lesion not able to be completely visualized by fv

Keywords: oral cancer oral dysplasia
protein supplementation and muscle recovery in football

Conditions: Skeletal Muscle Damage; Muscle Inflammation; Muscle Recovery; Soccer Performance

Summary: soccer is an intermittent sport including a high number of powerful actions such as accelerations, decelerations, changes of direction, jumps and impacts that incorporate a strong eccentric component and may therefore lead to skeletal muscle damage. indeed, match activity is associated with the onset of muscle damage and an acute inflammatory response that result in attenuated performance for as long as 1 to 3 days. in competitive soccer though, multiple matches are performed within a small-time frame resulting in inadequate muscle recovery and reduced field performance. supplementation with milk proteins following intense exercise protocols has been shown to stimulate protein synthesis and facilitate muscle recovery. thus, the aim of the present investigation is to examine the effects of milk protein supplementation on muscle recovery and soccer-specific performance during an in-season microcycle with two matches performed three days apart.

in a double-blind, cross over, repeated measures design 20 men soccer players will receive either placebo (pla) or milk protein isolate (pro, 80% casein-20% whey) throughout recovery following two matches performed three days apart. on match days, players will receive a dose immediately after the match (pla vs pro: 25g of protein) and then at 3h (pla vs pro: 30g of protein) and 6h (pla vs pro: 25g of protein) post-match. on each day of the remaining days, players will consume a single dose of pla or pro (20g of protein) with breakfast. all players will participate in regular in-season training following matches. field activity during both matches and daily practices will be monitored using gps devices. heart rate will be continuously recorded during each match and training session. blood samples will be collected at baseline as well as 2 hours after the first match, daily for three days after the first match, 2 hours after the second match and daily for 3 days after the second match. performance (isokinetic strength, 20-m speed, repeated sprint ability) and muscle soreness will be assessed at baseline daily for 3 days after both matches. muscle biopsies from vastus lateralis will be collected at baseline and one day after each match.

Eligibility criteria:
inclusion criteria: * i) participation at elite level (top three division leagues) of soccer competition for at least five years, ii) abstain from consumption of performance-enhancing supplements, antioxidant supplements and medications (for at least 6 months before and during the study), iv) participate in at least six two-hour training sessions per week and played at least one match per week and v) non-smokers. exclusion criteria: * i) a known milk intolerance or allergy, ii) a recent febrile illness, iii) history of muscle lesion, iv) lower limb trauma and v) metabolic diseases.
hemodynamic responses of stable ischemic heart disease patients to a comedy session

Conditions: Ischaemic Heart Disease

Summary: it is known that laughter can bring benefits in terms of physiological and psychological parameters, in addition to improving the individual's quality of life. however, the literature is still scarce as to the existence of studies investigating the effects of a comedy film specifically in hemodynamics.

objective: to evaluate the effect of a comedy film session on the cardiac index, systemic vascular resistance and vascular resistance index systemic in stable ischemic heart disease patients. method: randomized clinical trial. patients will be coming from ischemic heart disease clinic at the hospital de clínicas de porto alegre (hcpa), all in regular monitoring.

Eligibility criteria:
inclusion criteria: * ages between 40 and 80 years * both female and male * diagnosis of ischemic heart disease by cardiac catheterization , with 50% lesion in at least one epicardial vessel exclusion criteria: * participants enrolled in another randomized clinical trial * autoimmune diseases * valvulopathy with mechanical or biological cardiac prosthesis * presence of pacemakers and implantable cardioverter * left bundle branch block in the electrocardiogram (ecg) of 12 derivations * severe lung disease * depression or bipolar disorder * atrial chronic fibrillation * left ventricular dysfunction (ejection fraction \<45%) * active infection or neoplasia (not basal cell carcinoma) * chronic renal failure * illiteracy and inability to understand the consent form

Keywords: ischaemic heart disease comedy session laughter therapy
epidemiology and management of pediatric anaphylaxis and allergy in the pediatric emergency department of montpellier

Conditions: Anaphylaxis; Allergy

Summary: anaphylaxis is a severe life-threatening reaction following exposure to an antigen. its incidence is progressively increasing in the general population over years, especially among children. the diagnosis can be difficult, and recommendations for follow up and prescription for an emergency kit are rarely provided after emergency visit. the investigators will evaluate the management of pediatric anaphylaxis and clinical signs of allergy in the pediatric emergency department of montpellier university hospital


Eligibility criteria:
inclusion criteria: * patients evaluated at the montpellier university hospital, allergy unit ; * children consulting for suspected allergy from 2016 to 2020 exclusion criteria: - patients under legal protection, under guardianship or under curatorship;

Keywords: children emergency epinephrine
the feasibility of the peer-based recovery program

Conditions: Mental Disorder; Recovery, Psychological

Summary: recovery-oriented services are currently the mainstream in the field of mental health around the world. peer services are an alternative service option promoted by recovery advocates. western countries have invested abundant resources in promoting peer services and providing training for peer support workers. however, peer services in taiwan have just started. more resources need to be added to make mental health services catch up with the world trend so that people with mental illness in taiwan can have more choices. hence, this study aims to investigate the feasibility of the grow to recovery program-short version co-led by a peer.

the study will verify the feasibility of the grow to recovery program-short version co-led by a peer. based on the previous interview data and related literature, a peer leader training course will be established. one to three peers will be recruited to receive the training, and colead the grow to recovery program-short version with one trained professional. the pre- and post-test as well as course questionnaire data collected from program participants will be used to establish the feasibility.

Eligibility criteria:
inclusion criteria: * professionals: 1. working in the community psychiatric rehabilitation organizations 2. being willing to co-lead the recovery program with a peer * peers: 1. having a diagnosis of mental illness over 1 year 2. living in the community 3. being age 18 yr or older 4. having good communication skills 5. being willing to co-lead the recovery program with a professional * people with mental illness 1. having a diagnosis of mental illness over 1 year 2. living in the community 3. being age 18 yr or older 4. filling out the scales independently 5. being able to participate in a recovery group and follow the group rules exclusion criteria: * people with mental illness 1. attending another recovery-related group

Keywords: peer recovery program
the emergency department falls study

Conditions: Fall; Head Injury Trauma; Intracranial Hemorrhages

Summary: this is a pilot study to evaluate clinical predictors of intracranial bleeding in elderly patients who present to the emergency department (ed) after a fall. the aim is to assess feasibility and rate of patient recruitment, patient follow up, and to establish a point estimate for the incidence of intracranial bleeding in the investigator's population. currently there are no guidelines for ed physicians to assess the pretest probability of intracranial bleed in these patients, and no safe way to exclude a bleed without ct.

seniors account for 15% of the canadian population. the proportion will greatly increase over the next few years. elderly people attend the ed more often than younger people, and they often come to the ed after a fall at home or outside. falling is associated with head injuries, which cause half of all the deaths from falling. head injuries are diagnosed with ct scans. in the ed, it can be difficult for the physician to know when to perform a ct scan of the head. it can be hard to know if the elderly person hit their head, and often times, people with bleeding in the head can have a normal examination. the investigators think that the overall risk of bleeding in the head in elderly who fall is between 3 and 10%. if emergency physicians scanned every senior who fell, only a few would show bleeding, the scanning department would be overwhelmed, there would be increased costs for the hospital and longer delays for patients. it is important for physicians to diagnose a serious head injury as there are lifesaving treatments that can be given. the investigators plan to develop a decision rule for emergency physicians that would inform them which patients should have a ct scan of the head and which patients can have a serious head injury safely ruled out without a ct. the investigators propose to identify and recruit patients over the age of 65 who come to the hamilton general or juravinski emergency departments after falling. patients and their caregivers will be consented for a telephone follow-up call after 6 weeks. data collected will include patient characteristics, general health, and blood test results which might be predictors of a serious head injury. the investigators will develop a tool to help emergency physicians to order a ct scan on the right patients.

Eligibility criteria:
inclusion criteria: * 65+ years * presenting to the emergency department with fall on level ground, from a bed, from a chair, from the toilet seat or down steps 1 or 2 steps, within the last 48 hours exclusion criteria: * non-english speaking without an an adequate interpreter * falls with an other mechanism of injury * falls \> 48 hours before presentation

Keywords: seniors falls imaging emergency department ct head intracranial hemorrhages
a post-market clinical evaluation of the treatment of tibia fractures with the t2 alpha tibia nailing system

Conditions: Tibial Fractures

Summary: this investigation is a prospective, multi-center clinical investigation. it is anticipated that a total of 80 subjects will be enrolled. neither subjects nor investigators are blinded to treatment and the clinical investigation includes a historical control which will be compared to the t2 alpha tibia nailing system. total duration of enrollment, 12 month follow-up and analysis is expected to take 31 months. the clinical investigation has been designed to follow the surgeon's standard of care for tibia fractured subjects, in addition to a 12 month follow-up visit. the primary endpoint of this clinical investigation is to confirm efficacy/performance at 12 months, as measured by the sf-36 physical component summary (pcs). confirmation of efficacy/performance at 12 months will be based on an equal or higher (non-inferior) sf-36 physical component summary (pcs) result of the t2 alpha tibia nailing system compared to the benchmark literature.

the objective of this clinical investigation is to demonstrate the safety and efficacy/performance of the t2 alpha tibia nailing system. efficacy/performance of the procedure will be measured by an equal or higher (non-inferior) sf-36 physical component summary (pcs) score result of the t2 alpha tibia nailing system compared to the t2 tibia benchmark literature at 12 months. in addition, demonstration of bone consolidation in correct alignment will be measured by investigator assessment by 12 months. safety of the t2 alpha tibia nailing system will be demonstrated through reporting of device related intra-operative and post-operative adverse events/incidents by 12 months.

Eligibility criteria:
inclusion criteria: * subject is a male or non-pregnant female age 18 years or older at the time of surgery; * subject is willing and able to give written informed consent and comply with the requirements of this clinical investigation plan; * subject is intended to be, treated with the tibial nail of the t2 alpha tibia nailing system in accordance with the following legally cleared/ approved indications for use: indications for use approved in united states and canada include: * open and closed tibial fractures * pseudoarthrosis and correction osteotomy * pathologic fractures, impending pathologic fractures and tumor resections * fractures involving osteopenic and osteoporotic bone * nonunions and malunions exclusion criteria: * subject is currently enrolled in or plans to enroll in any concurrent drug and/or device clinical investigation that, in the opinion of the investigator, may confound results; * per the investigator, the subject is in poor general health or undergoing any concurrent disease that would place the subject in excessive risk to surgery (i.e. significant circulatory problems, cardiac disease).
study of dac combined with haag regimen in newly diagnosed younger aml patients

Conditions: Acute Myeloid Leukemia; Induction Chemotherapy

Summary: the purpose of this study is to evaluate the safety and efficacy of dac combined with haag regimen in the induction treatment of newly diagnosed aml patients younger than 60 years.

this is a phase 3, randomized, controlled, multi-center study in newly diagnosed aml patients younger than 60. the patients will be randomized to receive either dac combined with haag or ia regimen in the induction treatment.

Eligibility criteria:
inclusion criteria: 1. newly diagnosed aml according to the who (2016) classification of acute myeloid leukemia. 2. age 18-59. 3. ecog score: 0-2. 4. treatment related or secondary aml. 5. no history of previous chemotherapy or target therapy. 6. provide informed consent. exclusion criteria: 1. patients are pregnant or lactating. 2. patients have acute promylocytic leukemia or chronic myeloid leukemia in blast crisis. 3. patients with another malignant disease. 4. patients with uncontrolled active infection. 5. patients with left ventricular ejection fraction \< 0.5 by echocardiography or grade iii/iv cardiovascular dysfunction according to the new york heart association classification. 6. patients with aspartate aminotransferase or glutamic-pyruvic transaminase \> 3x upper limit of normal or bilirubin \> 2.0 mg/dl. 7. patients with creatinine clearance rate \< 50ml/min. 8. patients with active hepatitis b or hepatitis c infection. 9. patients with hiv infection. 10. patients with other commodities that the investigators considered not suitable for the enrollment.

Keywords: decitabine haag aml
topical 0.5% timolol solution for healing lower extremity wounds

Conditions: Wound Healing; Mohs Micrographic Surgery

Summary: topical timolol, a β2-adrenergic receptor (b2ar) antagonist, has demonstrated promise in wound healing over the past several years. the majority of the literature has evaluated the use of topical timolol to shorten wound healing time in chronic wounds of non-surgical etiologies. to date, there are no prospective randomized clinical trials evaluating the role of topical timolol for shortening wound healing time in acute open surgical wounds. therefore, the purpose of this study is to determine whether or not topical timolol solution decreases time to wound healing in patients with defects after mohs micrographic surgery (mms) that cannot be closed with sutures and are left to heal by second intent. the research team also will look to determine if there is a difference in cosmesis of wounds treated with topical timolol compared to those treated with the standard of care. the present study will primarily focus on wounds in the distal lower extremity as these are most commonly left to heal by secondary intent


Eligibility criteria:
inclusion criteria: * be scheduled to undergo mms at 234 east 85th st for a skin cancer that is deemed mohs * appropriate by the mohs surgery appropriate use criteria * have an open surgical wound \ 0.5 cm * be ≥18 years of age * english-speaking * provide a signed and dated informed consent form * state willingness to comply with all study procedures exclusion criteria: * age less than 18 years of age * open surgical wound \> 4 cm * if tumor clearance cannot be achieved with mms * pregnant women * breastfeeding women * patients who are taking oral beta-blockers (ie oral timolol, metoprolol, carvedilol, propranolol, atenolol) * patients who are currently taking any of the following medications: clonidine, digoxin, methyldopa, quinidine, fluoxetine and paroxetine, bupropion * patient currently taking a calcium channel blocker and has pre-existing heart failure as defined by a reduced ejection fraction * patients with pre-existing hypotension * pre-existing diagnosis of sinus bradycardia * pre-existing diagnosis of second or third degree atrioventricular block * congestive heart failure * pre-existing diagnosis of severe asthma * pre-existing diagnosis of chronic obstructive pulmonary disease * any known hypersensitivity to 0.5% timolol solution * patients who have a wound where primary closure is feasible and desired by the patient * defect size \<0.5 cm * prior sensitivity or known allergy to timolol
family involvement in the treatment of a mentally ill relative

Conditions: Families of Mentally Ill

Summary: * research demonstrates that the families of the seriously mentally ill are burdened by this caregiving role and by their responsibilities * research also demonstrates that family interventions are effective and that they have a potential to reduce family burden, as well as to improve the condition of the mentally ill patients. * we assume that the sibling group intervention would be effective in reducing the family burden of the siblings, and that this reduction would be reflected in their replies to the "experience of caregiving inventory".

* the group for siblings is an intervention which is carried out in the outpatient clinic of lev hasharon mental health center in cycles which last eight weeks; * every group cycle will include between 10-14 participants, all siblings of persons with mental illness. the patients themselves (ill siblings) are either hospitalized in lev hasharon mental health center, or are outpatients in the lev hasharon mental health outpatient unit, or in the community at large. * the group is an ongoing group: short term intensive group intervention in a dynamic orientation. veteran participants of each cycle are welcome to re-join at following cycles, and at the same time new participants can join at the beginning of each cycle. * participants will be asked to fill the "experience of caregiving inventory" twice: first time before the first meeting of a particular cycle of sibling group and second time: after the last (eighth) meeting of this group cycle.

Eligibility criteria:
inclusion criteria: * siblings of persons with mental illness exclusion criteria: * persons junior then 18 years old

Keywords: family members illness burden mental disorders family intervention
effectiveness of exercise and patient-centred education on fibromyalgia

Conditions: Fibromyalgia

Summary: this study aims to compare the effects of an eight-week exercise and patient-centred education programme with eight-week exercise alone programme on disability, pain intensity, health-related quality of life and patient global impression of change. a prospective, parallel, double-blinded and multi-centre randomised controlled trial will be carried out.


Eligibility criteria:
inclusion criteria: * diagnosis of fibromyalgia according to the american college of rheumatology criteria (2016) exclusion criteria: * presence of uncontrolled medical disorders (cardiovascular/ metabolic/ neurological/ renal) * presence of active oncological disease (or until 5 years and undergoing treatment) * presence of inflammatory rheumatic diseases other than fibromyalgia * presence of inflammatory osteoarticular disease or severe osteoarthritis (grade iv de kellgren - lawrence classification of osteoarthritis) * previous orthopaedic (column or lower limb) or cardiothoracic surgery in the year before; * disability not compatible with the exercise practice required * pregnancy * attendance to a physiotherapy programme including exercise in the previous three months * difficulty in written communication that prevent the fulfilment of self-reported questionnaires.

Keywords: fibromyalgia exercise patient-centred education randomised controlled trial
safety and effectiveness study of an experimental topical ointment (gs-9191) for the treatment of genital warts

Conditions: Genital Warts

Summary: the purpose of this study is to assess the safety, tolerability and activity of gs-9191 ointment in the treatment of genital warts. gs-9191 ointment is intended for topical application directly to genital warts on the skin.


Eligibility criteria:
inclusion criteria: * have 2 or more genital warts of prespecified sizes on external surfaces of the body. * if hiv positive, have hiv rna \< 400 copies/ml, cd4 count of ≥ 400 cells/mm3, and be taking a triple combination antiviral medication regimen exclusion criteria: * prior genital wart treatment within 8 weeks * pregnancy or breast-feeding * presence of broken or non-intact skin near the wart site or other skin disease at the wart site (e.g., herpes genitalis) * treatment with systemic steroids, systemic immunomodulators, immunosuppressants, or chemotherapeutic agents within 3 months * current or prior diagnosis of bowenoid papulosis, cancer, or pre-cancerous tissue in the genital area

Keywords: genital warts venereal warts human papilloma virus