Kornimate/medical-research-clean huggingface dataset:
internet-based cognitive-behavioral therapy for insomnia

Conditions: Insomnia

Summary: the aim of this study is to develop an internet-based self-help therapy program for insomnia in chinese language, and to conduct a randomized waiting-list controlled trial on the efficacy of internet-based self-help therapy for insomnia.

this study is a randomized controlled trial in patients with insomnia. eligible subjects will be randomly assigned to self-help treatment with telephone consultation (shtc), self-help treatment without telephone consultation (sh), or waiting-list control. the subjects will receive self-help treatment once per week for 6 consecutive weeks. in addition to self-help treatment, the subjects in shtc group will receive telephone consultation once per week for 6 consecutive weeks.

Eligibility criteria:
inclusion criteria: * hong kong residents aged ≥18 years * predominant complaint of difficulty initiating or maintaining sleep or early morning awakening or nonrestorative sleep with associated distress or impairment in social, occupational and other important areas of functioning for at least 3 nights per week for at least 3 months based on self- administered questionnaire * able to read chinese and type chinese or english * have internet access (pc/ mobile phone), and with an email address * willing to give informed consent and comply with the trial protocol exclusion criteria: * have suicidal ideas based on self-report

Keywords: insomnia cognitive-behavioral therapy internet-based self-help randomized controlled trial
supplemental egg protein intervention in older adults

Conditions: Sarcopenia; Aging

Summary: older adults are at risk for developing sarcopenia, or age-related muscle loss, which increased the risk of disabilities, falls, and loss of independence. many older adults do not consume enough protein each day to maintain their muscle mass and this study aims to investigate if consumption daily egg white protein supplement can help maintain muscle mass and functionality in community-dwelling older adults. food insecure older adults that attend congregate nutrition sites will be targeted.

the study aims to evaluate the impact of egg white protein supplementation on muscle mass, strength, and physical function in older adults with low muscle mass or function. older adults will be recruited from san antonio, texas, the least food secure metropolitan area for older adults. the project will be conducted entirely at community locations such as congregate meal sites, senior activity centers, and housing communities. researchers will conduct recruitment, distribution of supplements and pre and post assessments entirely at these sites, which will alleviate the travel of participants to research sites and provide a unique opportunity to assess this underserved population. one hundred older adults (≥60yrs old) will be randomly assigned to consume a daily supplement of egg white protein or isoenergetic carbohydrate for 6 months. changes in skeletal muscle mass, muscle strength, and physical function will be assessed.

Eligibility criteria:
inclusion criteria: * 60 years or older, gait speed \>0.8m/s or hand grip below 20kg for women or below 30kg for men exclusion criteria: * over 300 pounds, kidney disease, has taken a protein supplement within the past 30 days, dementia/alzheimer's, uncontrolled diabetes, wheelchair bound, vegan, allergic to eggs, blind/legally blind, history of stroke/transient ischemic attack with a barthel score of 15 or lower, cannot read or write english or spanish and don't have someone to help them with forms/paperwork, not willing to take a supplement for 6 months or will not remain in the local area for the study period.

Keywords: physical performance battery 24-hour dietary recalls dual-energy x-ray absorptimetry dietary supplement protein
hipec as neoadjuvant treatment for resectable pancreatic adenocarcinoma

Conditions: Pancreatic Neoplasms; Pancreatic Adenocarcinoma

Summary: this single-center, prospective proof-of-concept study is designed to evaluate the surgical outcomes and clinicopathologic results of neoadjuvant hyperthermic intraperitoneal chemotherapy (hipec) in conjunction with perioperative systemic chemotherapy (sct; neoadjuvant and adjuvant) and pancreaticoduodenectomy (pd) in a small cohort of patients having t1-t3 resectable pancreatic ductal adenocarcinoma (pdac) with one or more high-risk clinical features. the investigators hypothesize that hipec administered in this clinical course will reduce postoperative peritoneal disease recurrence. the investigators also expect that local recurrence of disease will be reduced. the primary aim of this study is to compare 2-year peritoneal disease-free survival between patients receiving the experimental therapy (neoadjuvant hipec + sct + pd) with historical controls receiving standard therapy (sct + pd). secondary aims are to determine the clinical feasibility and outcomes of neoadjuvant hipec for resectable pdac using patient demographics and disease characteristic data.


Eligibility criteria:
inclusion criteria: * primary diagnosis of pancreatic ductal adenocarcinoma (pdac) confined to the head of the pancreas classified as t1-t3 with one or more of the following high-risk clinical features: * carbohydrate antigen (ca) 19-9 greater than 1,000 u/ml with a normal bilirubin; * vascular involvement; and/or * suspicious regional lymphadenopathy * intention to undergo open pancreaticoduodenectomy (standard whipple or pylorus-preserving pancreaticoduodenectomy) as treatment for pdac * adequate clinical condition to undergo preoperative (neoadjuvant) hyperthermic intraperitoneal chemotherapy * adequate clinical condition to undergo perioperative systemic chemotherapy * white blood cell count of at least 3000/ml * platelet count of at least 100,000/ml * normal creatinine (\< 2 mg/dl) or creatinine clearance of at least 50 ml/min * willing and able to give informed consent exclusion criteria: * evidence of locoregional spread (carcinomatosis of peritoneal surfaces, mesenteric arteries, or body/tail of pancreas) or distant (liver, lung, or other) metastases (histological, ct, or mri confirmation) * non-curative intent of treatment (≥r2 resection) * body mass index (bmi) \> 35 * previous history of pancreatic resections for tumors in the body and/or tail of the pancreas, distal cholangiocarcinoma, duodenal carcinoma, neuroendocrine tumors, cyst-adenocarcinoma, or solid and papillary tumors. * unstable or uncompensated respiratory or cardiac disease * severe hepatic or renal dysfunction * bleeding diathesis or coagulopathy * pregnant or nursing women

Keywords: hyperthermic intraperitoneal chemotherapy perioperative systemic chemotherapy peritoneal disease
predictive value of revised trauma score(rts)and glasgow coma scale (gcs)of mortality in patients with multiple trauma.

Conditions: Polytrauma Patients

Summary: this study aims to assess the efficacy of rts and gcs in predicating the mortality among multiple trauma patients admitted to emergency departments at assiut university hospital.which score is better in predicting mortality in polytrauma patients revised trauma score (rts) or glasgow coma scale (gcs) of with multiple trauma?

trauma is a serious global health problem. globally around 5.8 million people deaths were estimated from injuries in 2004. these deaths accounted for 10% of the world's mortality\[1\]. it is the fifth leading cause ofsignificant, disability and sixth leading cause of death\[2\]. more than 90% of the world's injury deaths occur in low- and middle-income countries\[3\]. injury deaths in egypt accounted for 8% and the eighth leading cause of death in 2010\[4\]. there was an increase in the number of hospitalization due to trauma. in upper egypt, trauma cases increased from 19,869 up to 32,699 with death rate 1.2/100 cases per year throughout the period from 2002 to 2009.in multiple trauma patient management, time is crucial. early intervention has consistently been shown to reduce mortality and morbidity\[5\]. prompt and effective care \[6\]. these scores either measure the alteration in patient's physiology; glasgow coma scale (gcs) and revised trauma score (rts) or anatomy; injury severity score (iss)\[7\]. glasgow coma scale (gcs) is one of the most commonly used trauma scores and is a good predictor of the outcome. the gcs is primarily utilized to evaluate the level of consciousness impairment in patients, achieved through the assessment of ocular, motor, and verbal response\[8\].the revised trauma score (rts) are considered the most practical and effective \[9\].the rts stands out because it can be quickly calculated using a patient's initial clinical status and vital signs at presentation, making it particularly useful during the critical "golden hour" after arrival\[10\]

Eligibility criteria:
inclusion criteria: * 1-patients aged from \> 18 years old. 2-both male and female. 3-patients have penetrating and blunt trauma. exclusion criteria: * 1-pregnant women. 2-patients with mild trauma such as soft tissue damage and 3-isolated limb fractures. 4-patients were transferred to another hospital. 5-failure of follow-up for any reason. 6-patients who refused participatioc.

Keywords: predictive value of revised trauma score(rts)and glasgow coma scale (gcs)of mortality in patients with multiple trauma in emergency department
influence of co-existing mutations on sorafenib maintenance therapy after allo-hsct for patients with flt3-itd aml

Conditions: Acute Myeloid Leukemia; Acute Myeloid Leukemia With FLT3/ITD Mutation; Hematopoietic Stem Cell Transplantation

Summary: the purpose of this study is to reveal the influence of co-existing mutations on the efficacy of sorafenib maintenance after allogeneic hematopoietic stem cell transplantation for patients with flt3-itd aml.

internal tandem duplication of fms-like tyrosine kinase 3 (flt3-itd) mutations have been reported in 20%-30% of patients with acute myeloid leukemia (aml). flt3-itd-positive aml patients have an inferior survival, primarily due to lower complete remission (cr) rate and higher relapse rate. our previous studies demonstrated that post-transplantation sorafenib maintenance could improve the outcomes of flt3-itd-positive aml patients. however, whether other co-existing mutations influence the efficacy of post-allo-hsct sorafenib maintenance remains unknown.

Eligibility criteria:
inclusion criteria: * flt3-itd positive aml * allo-hsct recipients exclusion criteria: * cardiac dysfunction (particularly congestive heart failure) * hepatic abnormalities (bilirubin ≥ 3 mg/dl, aminotransferase\> 2 times the upper limit of normal) * renal dysfunction (creatinine clearance rate \< 30 ml/min) * any abnormality in a vital sign (e.g., heart rate, respiratory rate, or blood pressure) * patients with any conditions not suitable for the trial (according to the investigators' decision)

Keywords: acute myeloid leukemia flt3-itd hematopoietic stem cell transplantation sorafenib
the effect of low flow anesthesia on postoperative emergence agitation in rhinoplasty

Conditions: Emergence Agitation; Anesthetics; Rhinoplasty

Summary: emergence agitation, defined as restlessness, disorientation, arousal, and/or inconsolable crying, is a common phenomenon seen in the early phase of recovery from general anesthesia; this may cause respiratory depression, nausea and vomiting, as well as an increase in blood pressure, heart rate and myocardial oxygen consumption. although its pathogenesis remains unclear, ent (ear, nose and throat) surgical procedures have been reported to have a higher incidence of agitation in both adults and children. in recent years, low-flow inhalation anesthesia has been widely used in adult anesthesia practice. the aim of this study is to compare the effects of low flow anesthesia and normal flow anesthesia on emergence agitation.

emergence agitation, defined as restlessness, disorientation, arousal, and/or inconsolable crying, is a common phenomenon seen in the early phase of recovery from general anesthesia; this may cause respiratory depression, nausea and vomiting, as well as an increase in blood pressure, heart rate and myocardial oxygen consumption. hypoxia can lead to serious complications such as aspiration pneumonia, bleeding or reoperation. although its pathogenesis remains unclear, ent (ear, nose and throat) surgical procedures have been reported to have a higher incidence of agitation in both adults and children. in recent years, low-flow inhalation anesthesia has been widely used in adult anesthesia practice. low flow anesthesia has many advantages; the consumption of inhalation agents is reduced, the temperature and humidity of the airways are maintained, the cost of anesthesia and pollution caused by atmospheric waste gases are reduced. in addition, because the temperature and humidity of the tracheobronchial tree are preserved, respiratory functions and mucociliary activities are better preserved. in low-flow anesthesia, the concentration of inhaled anesthetics changes very slowly, and their concentration gradually decreases after the administration is terminated. since the anesthetic concentration will slowly decrease in the low-flow group during termination of anesthesia, the concentration difference between the brain and lungs will be small. in addition, it is known that a longer period between discontinuation of the administration of anesthetic agents and extubation reduces emergence agitation. this seems possible with the low-flow anesthesia technique. the aim of this study is to compare the effects of low flow anesthesia and normal flow anesthesia on emergence agitation.

Eligibility criteria:
inclusion criteria: * 18-50 years * asa class i-ii, * scheduled for elective rhinoplasty surgery under general anesthesia exclusion criteria: * history of allergy to nonsteroidal anti-inflammatory drugs, * bleeding diathesis or anticoagulant use, * psychiatric drug use, * previous rhinoplasty surgery * patient refusal

Keywords: emergence agitation anesthetics
hcr vs. cabg study

Conditions: Coronary Artery Disease

Summary: the purpose of the study is to find out if hybrid coronary revascularization (hcr) and coronary artery bypass grafting (cabg) procedure outcomes are similar. hcr is a combination of surgery and catheter procedures to open up clogged heart arteries. cabg is a surgical procedure to open up clogged heart arteries.

currently, it is not clear how the outcomes of hybrid coronary revascularization (hcr) compare with other treatments. the purpose of the study is to find out if hcr and coronary artery bypass grafting (cabg) procedure outcomes are similar. hcr is a combination of surgery and catheter procedures to open up clogged heart arteries. cabg is a surgical procedure to open up clogged heart arteries. this study will collect information about the medical care participants receive during their planned procedure. no new testing or procedures will be done. participants will have only the tests or procedures already planned by their doctor. the investigators will look at how well participants do after the procedure by assessing the outcomes of interest 30 days after surgery and, potentially, one year after surgery (funding dependent).

Eligibility criteria:
inclusion criteria: * able to give informed consent * have multi-vessel coronary artery disease (cad) involving the left anterior descending (lad) artery * have a clinical indication for revascularization * are a candidate for either hcr or cabg or both * anatomy suitable for hcr shall include 1. multi-vessel cad involving the lad and/or 2. lad disease and involvement of a major diagonal artery, both of which require revascularization exclusion criteria: * prior cardiac operations * severe left ventricular dysfunction with ejection fraction (ef) \< 30% * patients with chest radiation * body mass index (bmi) \> 35 * severe peripheral vascular disease (pvd) * acute ischemia requiring emergent traditional coronary artery bypass graft (cabg)

Keywords: coronary arteriosclerosis hybrid coronary revascularization coronary artery bypass grafting
the world (weight optimization: revamping lifestyles using the dietary guidelines) study - developing, implementing, and testing an education program

Conditions: Obesity; Cardiovascular Disease

Summary: the world study is a single-center, year-long randomized controlled trial in free-living women. participants were randomly assigned to follow either a lower-fat (lf) diet or a moderate-fat (mf) diet for weight management in a parallel-arm design. the two phases of the study were a weight-loss phase (phase 1) and a weight-maintenance phase (phase 2) (figure 1). during phase 1, months 1 through 4, participants consumed a hypo-caloric diet consistent with the 2005 dietary guidelines in the free-living environment. during phase 2, months 5 through 12, participants shifted into weight maintenance. it was hypothesized that a weight-loss intervention at the extremes of dietary fat recommendations of the 2005 dietary guidelines would be equally effective for weight loss while achieving comparable nutrient adequacy. also, overall, the lower-fat and moderate-fat diets would both be nutritionally adequate, based on the healthy eating index.


Eligibility criteria:
inclusion criteria: * 21-50 years * bmi: 25-39.9 kg/m2 * ldl-c: 100-189.9 mg/dl exclusion criteria: * triglycerides \> 350 mg/dl * history of myocardial infarction, stroke, diabetes mellitus, liver disease, kidney disease, and thyroid disease * high alcohol consumption (\<14 drinks/week) * use of medication or supplements for lowering blood lipid levels (i.e., statin, fibrates, psyllium, fish oil capsules, soy lecithin, phytoestrogens) * lactating, pregnant, or wanting to become pregnant during the study * weight loss or gain ≥ 10% body weight in the previous 6 months * eating attitudes test-26 score \> 20 * beck depression inventory-ii score ≥ 29 * gormally cognitive factors related to binge eating scale score \> 30 * physical activity readiness questionnaire score \> 2

Keywords: weight loss weight maintenance weight management cardiovascular disease risk dietary guidelines diet and exercise prevention
a pharmacokinetic study to access how the body absorbs and removes abt-199 in adults with non-hodgkin's lymphoma

Conditions: Relapsed/Refractory Non-Hodgkin's Lymphoma

Summary: a pharmacokinetic study to access how the body absorbs and removes abt-199 in adults with non-hodgkin's lymphoma.


Eligibility criteria:
inclusion criteria: 1. subject must have relapsed or refractory disease. 2. subject must have histologically documented diagnosis of non-hodgkin's lymphoma as defined by a b-cell neo-plasm in the world health organization (who) classification scheme except as noted in exclusion criteria. 3. subject has an eastern cooperative oncology group (ecog) performance score of 0-2. 4. subject has adequate bone marrow (independent of growth factor support per local laboratory reference range). 5. subject has adequate coagulation, renal and hepatic function. exclusion criteria: 1. subject has been diagnosed with post-transplant lymphoproliferative disease (ptld), burkitt's lymphoma, burkitt-like lymphoma, lymphoblastic lymphoma/leukemia, chronic lymphocytic leukemia (cll), mantle cell leukemia (mcl), or small lymphocytic lymphoma (sll). 2. subject has undergone an allogeneic stem cell transplant. 3. subject is receiving combination anti-retroviral therapy for human immunodeficiency virus (hiv) (due to potential drug-drug interactions, as well as the potential for increased risk of opportunistic infections). 4. subject has a significant history of renal, neurologic, psychiatric, endocrinologic, metabolic, immunologic, cardiovascular, or hepatic disease within 6 months that in the opinion of the investigator would adversely affect his/her participation in this study. 5. subject has active peptic ulcer disease or other hemorrhagic esophagitis/gastritis.

Keywords: gdc-0199 adme relapsed refractory abt-199 non-hodgkin's lymphoma
safety and efficacy study evaluating dimebon in patients with mild to moderate alzheimer's disease on donepezil

Conditions: Alzheimer's Disease

Summary: the purpose of this study is to determine if dimebon is safe and effective in patients with mild to moderate alzheimer's disease on donepezil.


Eligibility criteria:
inclusion criteria: * mild-to-moderate alzheimer's disease (ad) * probable ad (diagnostic statistical manual of mental disorders-iv-text revision (dsm-iv-tr)) * mini-mental state examination (mmse) score between 12 and 24, inclusive * stable on donepezil for at least 6 months exclusion criteria: * other causes of dementia * major structural brain disease * unstable medical condition or significant hepatic or renal disease

Keywords: alzheimer's disease clinical trial mitochondria memory loss neurodegenerative disease dementia investigational drug
randomized control trial to study the efficacy of the surgical mask versus the n95 respirator to prevent influenza

Conditions: Influenza

Summary: the goal of this study is to compare the efficacy of the surgical mask to the n95 respirator in protecting nurses from influenza in the hospital setting. the investigators propose a non-inferiority randomized controlled trial whereby nurses are randomized to either a surgical mask or an n95 respirator when caring for patients with febrile respiratory illness during the influenza season. the hypothesis is that the surgical mask offers similar protection against influenza to that of the n95. the specific objective of the study is to assess whether the rates of influenza (laboratory-confirmed by pcr and hai assay), as well as secondary outcomes (influenza-like illness, work-related absenteeism, physician visits for respiratory illness, and lower respiratory infection), are similar among nurses using a surgical mask compared to those using an n95 respirator.


Eligibility criteria:
inclusion criteria: * nurses who work in emergency departments and medical units * nurses expected to work full time (defined as \> 37 hours per week) exclusion criteria: * nurses who were not fit tested * nurses who could not pass a fit test

Keywords: n95 respirator mask influenza efficacy