Kornimate/medical-research-clean huggingface dataset:
effect of ureteral access sheath use on postoperative pain level in patients undergoing rirs

Conditions: Urolithiasis

Summary: this study will include patients aged between 18 and 70 who will undergo retrograde intrarenal surgery (rirs) due to renal stone(s). a total of 80 patients (male or female) will be recruited, and will be randomized into 2 groups consisting of 40 patients in each group. the first group of patients will undergo rirs with a ureteral access sheath (uas) positioned prior to surgery; and the second group will undergo rirs without uas. as use of uas decreases the pressure in the renal pelvis during rirs, it is aimed to evaluate whether using uas or not affects the level of pain felt by patients in the postoperative period.

the level of pain of the patients in both groups will be evaluated by using visual analog score (vas) and verbal rating score (vrs) in the postoperative 0 min (the moment patients gets consciousness after he/she wakes up from general anesthesia), 10th min, 30th min, 60th min and 120th min.

Eligibility criteria:
inclusion criteria: * being between 18-70 years old * having an indication of retrograde infrarenal surgery (rirs) due to kidney stone exclusion criteria: * patients with uncontrolled diabetes mellitus and diabetic nephropathy * patients with blood pressure \> 140/80 mmhg despite regular use of antihypertensive agent(s) * patients with chronic kidney failure who need dialysis * patients who have had prerenal, renal or postrenal acute kidney failure 3 months or much earlier * patients who have had pyelonephritis 3 months or much earlier * patients younger than 18 years or older than 70 years * patients who have undergone a kidney surgery within the last 3 months and have abnormal kidney function tests * patients with a concomitant ureter stone who will undergo an endoscopic ureter stone treatment at the same session * patients using any kind of medication that can affect his/her perception of pain

Keywords: renal stone retrograde intrarenal surgery ureteral access sheath pain
role of udumbara sutra in the management of fistula in ano a rare case study

Conditions: Fistula in Ano

Summary: the anal fistula is a notorious disease due to its recurrence rate. bhagandara is varyingly defined as a tear, ulcer or boil at bhaga (perianal region) within 2 finger circumference of it, causing painful abscess when opened is called bhagandara. the sanskrit word 'bhagandara' has got two components-bhaga and darana. bhaga means perianal region and darana means to tear. the ancient surgeon sushruta has advocated various types of operations in sushruta samhita. he has advocated kshara sutra treatment due to probability of recurrence after surgery. sushruta describes many kind of kshara like palasa, kadali. the most remarkable is udumbara( ficus glomerata) among them. the present treatment modality udumbara kshara sutra has been found effective due to its action of proper drainage of pus from the fistula that leads to a proper healing and as adjuvant therapy by avoid recurrence in fistula in ano. hypothesis; present treatment modality udumber sutra will found to be useful in tne management of fistula in ano.

a 5 year male child, come with complaints of painful discharging boil at left side of perianal region and pain with surgical history of incision and drainage for gluteal abscess done before six month. on local examination patient had discharging sinus at 8 o' clock position on right side of perianal region. before planning the treatment other aetiologies were ruled out. under short general anaesthesia diagnosis was confirmed by probing as fistula in ano. internal opening of fistula was confirmed by injecting methylene blue dye through external opening. the track was directed upward in the anal canal without any tributary. length of the tract was 3cm, suggestive of low anal fistula. then udumbara sutra was tied covering the entire underlying track for cutting and healing under all aseptic precaution. the patient was discharged on the next day of procedure. the udumbara sutra was changed skilfully by weekly. to promote healing and to reduce pain and inflammation oral antibiotics, anti-inflammatory medicine were also prescribed. the total period of udumbara sutra treatment was 1,1/2 month. the track cut through and simultaneously healed. the patient was observed for a period of 6 month to check for recurrence. the sutra or medicated seton was a standard medicated thread smeared with latex of udumbara (ficus glomerata), which has quality of cutting and healing.

Eligibility criteria:
inclusion criteria: * patient without any major illness. fistula in ano without tributaries ano without complication. exclusion criteria: * multiple fistula and associated ano rectal conditions.

Keywords: fistula in ano bhagandara udumbara sutra
risk factors for post whipple pancreatic fistula

Conditions: Pancreatic Fistula

Summary: postoperative pancreatic fistula (popf) following pancreaticoduodenectomy is considered a life-threatening complication. this study was designed to analyze the risk factors for development of such fistula in a tertiary care center (al-rajhi liver hospital/ assiut university).


Eligibility criteria:
inclusion criteria: * all patients underwent pancreaticoduodenectomy for pancreatic cancer exclusion criteria: * all types of pancreatic resection other than pancreaticoduodenectomy
deaf weight wise 2.0: a healthy lifestyle intervention with deaf adults who are overweight or obese

Conditions: Overweight; Obesity

Summary: the purpose of the deaf weight wise 2.0 (dww 2.0) study is to test an evidence-based, comprehensive program to modify obesity-related health behaviors with deaf people ages 21 to 70 who use american sign language (asl) as their primary language. participants will be randomized to one of four arms: immediate intervention vs. intervention delayed one year, and in-person group intervention vs. individual intervention delivered via videophone. the investigators' primary hypothesis is that participants in the immediate dww 2.0 intervention will increase their physical activity and reduce their caloric intake and body weight compared with those in the delayed intervention group (no intervention yet).


Eligibility criteria:
inclusion criteria: * deaf men and women ages 21-70 years who use sign language and live in the rochester metropolitan statistical area (msa), * have a body mass index (bmi) of 25-45. * eligible subjects must also have permission to participate from a primary healthcare provider if: 1) self-reported diagnosis of a recent cardiovascular disease event (heart attack or stroke in past 6 months), 2) self-reported heart condition, chest pain, dizziness, or other reason not to participate in physical activity, 3) had weight loss surgery in the previous 2 years (self-reported), and 4) are pregnant (self-reported). * subjects must also be willing to follow a healthy dietary pattern and to abstain from using weight loss medications during the study, and be willing and able to attend either group or videophone sessions, and to participate in data collection requirements. exclusion criteria: * exclusion criteria include: subjects without medical clearance who had 1) a cardiovascular disease event in the past six months, 2) or heart condition, chest pain, dizziness, or other reason not to participate in physical activity, 3) or weight loss surgery in the past two years, or 4) are pregnant. participants with these conditions (as determined by the par-q physical activity readiness-questionnaire and other questions administered during the initial study screening visit) must obtain medical clearance from their primary healthcare clinician (or maternity care clinician for pregnancy) to be eligible. those who are unable or unwilling to provide written, informed consent, and inability to see and interact with computer-based questionnaires and educational interventions will be excluded.

Keywords: deaf american sign language overweight obese
the effects of maxipost (bms 204352) on cerebral hemodynamic and headache in healthy volunteers and migraine patients

Conditions: Headache, Migraine

Summary: it is not previously investigated whether, there is a correlation between potassium channels and migraine, so it is unclear whether, this signaling pathway through potassium channels has an impact on migraine pathophysiology. maxipost (bms 204352) is a vasoactive molecule that causes vasodilation via the big calcium dependent potassium (bkca) channel signaling pathway. maxipost decreases the blood pressure and maxipost infusion causes headache in healthy volunteers. a possible coherence between maxipost and headache/migraine in healthy volunteers and migraine patients is yet to be investigated. the present study aims to clarify a possible coherence between maxipost and headache/migraine and it will help to shed light on the importance of potassium channels in migraine. in general, the study will contribute to a greater understanding of migraine pathogenesis and possibly lead to development of specific migraine treatment.


Eligibility criteria:
inclusion criteria: * migraine patients without aura who fulfill criteria in the international classification of headaches. this does not apply to healthy volunteers. * 18-60 years. * 50-90 kg. * women of childbearing potential must use adequate contraception. exclusion criteria: * headache less than 48 hours before the tests start * all primary headaches, except migraine without aura for migraine patients, according to international classification of headache * daily consumption of drugs of any kind other than oral contraceptives * pregnant or nursing women. * cardiovascular disease of any kind, including cerebrovascular diseases.
near normalisation of bg improves the potentiating effect of glp-1

Conditions: Diabetes Mellitus Type 2

Summary: the ability of glucagon-like peptide 1 to enhance beta-cell responsiveness to i.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. we investigated whether 4 weeks of near-normalisation og blood glucose improves the potentiation of glucose-stimulated insulin secretion by glp-1


Eligibility criteria:
inclusion criteria: * age 18-70 years * type 2 diabetes diagnosed after 30 years of age * bmi \> 25 exclusion criteria: * severe complications to diabetes * abnormal liver og kidney function * haemoglobin below the lower limit * macroalbuminuria * systemic disease * pregnancy
subcutaneous immunotherapy treatment for patients with hypersensitivity to olea europaea pollen

Conditions: Rhinitis or Rhinoconjunctivitis With or Without Asthma Induced by Hypersensitivity to Olea Europea Pollen

Summary: the objective of this trial is to assess the clinical efficacy of a modified allergen extract of olea europaea pollen in the treatment of patients affected by allergic rhinitis/rhinoconjunctivitis (with or without episodic asthma) induced by hypersensitivity to olea europaea pollen, evaluating the score regarding symptoms and consumption of the medication.

immunotherapy is a specific treatment for allergic diseases. unlike conventional pharmacological treatment, immunotherapy is the only treatment that could modify the natural course of allergic disease. this is a prospective double-blind placebo-controlled study with two arms of treatment: placebo and active.

Eligibility criteria:
inclusion criteria: * prior to study specific examinations the patient and if applicable both legal guardians has to give his/her written informed consent * patients of both gender aged from 18 and 55 years * patient's perception of disease activity of at least 30 mm on a 100 mm visual analogue scale (vas) * fev1 greater or equal than 80% of the expected value, and if not, improvement of fev1 greater than 12% after bronchodilation * patients have to suffer from allergic complaints (rhinitis and/or rhinoconjunctivitis with or without mild intermittent allergic asthma) caused by clinical sensitization against olea europaea pollen. the ige mediated sensitization has to be verified by: * suggestive medical history * specific ige against olea europaea pollen cap rast ≥0.7ku/l * positive skin prick test (spt) to grass olea pollen resulting in a wheal diameter of at least 3 mm. exclusion criteria * history of significant clinical manifestations of allergy as a result of sensitization against weed pollen allergens and perennial (e.g. house dust mite. * participation in an immunotherapy with comparable extracts within the last five years. * treatment with β-blocker * any disease which prohibits the use of adrenaline (e.g. hyperthyroidism) * cardiovascular insufficiency or any severe or unstable pulmonary, or endocrine disease; clinically significant renal or hepatic disease or dysfunction; hematologic disorder; any other clinically significant medical condition that could increase the risk to the study participant * immunopathological diseases * patients who are expected to be non-compliant and/or not co-operative * women, where pregnancy is defined as the state of a female after conception and until the termination of gestation

Keywords: immunotherapy allergoid depigmented polymerized allergen-extract rhinoconjunctivitis
effects of bandaging and kinesiotaping® in patients with total knee arthroplasty

Conditions: Knee Osteoarthritis

Summary: the study aimed to compare the effectiveness of elastic bandaging, kinesio taping, and short stretch bandaging techniques on postoperative pain, edema, and functional level in the early stage after total knee arthroplasty.

the study was conducted on 30 volunteer subjects who underwent unilateral total knee arthroplasty surgery. thirty participants who underwent unilateral total knee arthroplasty were divided into the elastic bandage group (n=10), kinesio tape group (n=10), and short stretch bandage group (n=10). all treatments were stopped on the eighth day. all measurements taken preoperatively were repeated postoperative 1st, 3rd, 5th, 8th, 14th, 28th days, 6th week, and 3rd month. the functional level was measured in the sixth week and third month.

Eligibility criteria:
inclusion criteria: * 60 years or older patients who had undergone unilateral tka surgery for primary knee osteoarthritis, rheumatoid arthritis, and posttraumatic arthritis. exclusion criteria: * body mass index greater than or equal to 35 kg/m2, * having a neurological or peripheral vascular disease, * having a contraindication condition for compression application (e.g., acute cellulitis, arterial insufficiency, unstable heart disease, acute deep vein thrombosis), and kinesio taping application (e.g., presence of active infectious, lymphedema and/ or cancer history)

Keywords: knee arthroplasty edema elastic bandages short stretch bandages kinesio tape
adrenocorticotropic axis and neuropathic pain

Conditions: Neuropathic Pain

Summary: chronic pain is often associated with a chronic stress and hhsg axis plays a pivotal role in maintaining homeostasis. the literature reports that pain in patients treated with opioids, significant changes are taking place in this axis with a collapse in hormone concentrations that are correlated with the decline on tests of quality of life and psychological testing. the investigators hypothesis is that this "endocrinopathy" could also be present in patients treated for neuropathic pain with other drug classes as opiates (antidepressants, antiepileptics), and may explain, at least in part, the impairement of the quality of life of these patients.

day of inclusion: blood sample for analysis of several hormones (cortisol, acth, shbg, total testostérone et s-dhea, βœstradiol et progestérone for women, lh, fsh). day +1: salivary samples (at wake-up, 30 minutes after wake-up, at lunch, at 06:00 pm and before sleep). day +2: salivary samples (at wake-up, 30 minutes after wake-up).

Eligibility criteria:
inclusion criteria: * group of patients * patients older than 18 years, * male or female with bmi between 18 and 35, * patients with chronic neuropathic pain for more than six months, except to diabetes or central neuropathic pain * patients receiving systemic therapy for treating chronic neuropathic pain such as antidepressants, anticonvulsants or opiates for at least 6 months. group of healthy volunteers * non-painful healthy volunteers matched by age, sex, bmi and menopausal status for women, * free of analgesics within 8 days before the test, * aged over 18 years, * male or female, exclusion criteria: * subjects with a medical history and / or surgical judged by the investigator or his representative as being incompatible with the test * patients treated only by topical treatment (lidocaine patch only for example) * pateints receiving corticosteroid treatment at the time of enrollment, or who received such treatment during the last 6 months (regardless of the dosage form and dosage), * inflammatory and evolutive pathology requiring long term treatment, * type 2 diabetes, * postmenopausal women with replacement therapy, * weight change of more than 5% within 3 months before the study, * bmi \ 35,

Keywords: neuropathic pain adenocorticotrophic axis psychological state
nutrition education intervention for plhiv

Conditions: Hiv; Nutritional Deficiency

Summary: the study tested two hypotheses, which are mentioned below: hypotheses: the project will test 5 hypotheses related to the various aspects of the study. h1: implementing a nutrition education intervention will significantly improve the patient's nutritional knowledge, dietary practices, and attitudes (kap) post-6 months of intervention. h2: implementing a nutrition education intervention will significantly improve the patients' food intake of immune-boosting foods, physical activity levels, anthropometric measurements, nutrition-related biochemical biomarkers, and mental health status, post the intervention period. note: h2 is a complex hypothesis consisting of 5 sub-hypotheses corresponding to the five mentioned measurements (food intake of immune-boosting foods, physical activity levels, anthropometric measurements, nutrition-related biochemical biomarkers, and mental health status). each of these sub-hypotheses will be statistically tested.

the intervention was guided by the health belief model. the topics to be covered and the content of the educational program were designed with input from dietitians working with plhiv to ensure the relevance for the target participants. participants randomized into the intervention group received individualized sessions with a registered dietitian once a month for 6 months. during the sessions, the dietitian elaborated on the medical nutrition therapy for each participant which consists of nutritional diagnosis and nutritional counseling services. topics covered include general nutrition knowledge, myplate food groups, immune-boosting foods and nutrients, improving physical activity levels, the nutritional aspects of the existing co-morbidities such as hypertension, diabetes, etc. the intervention provided by the dietitian (primary investigator) which was guided by the health belief model (hbm) which suggests that an individual's beliefs about health threats, perceived benefits of acting, and perceived barriers to acting are key determinants of health-related behaviors. each session lasted for approximately 30-45 minutes through virtual platforms or in-person, or a combination of both, using several teaching tools such as discussions, demonstrations, educational materials, and educational videos. the participants were met with online once per month and they were followed up on weekly basis on whatsapp to reinforce the last session message.

Eligibility criteria:
inclusion criteria the inclusion criteria were patients of: * more or equal to 18 years of age; * who have the virus with or without any co-morbidities; * and who give consent to participate. exclusion criteria: * patients who are imprisoned; * and/or refuse to participate were excluded. disclaimer: prisoners were excluded as their confinement and lack of access will hinder them from receiving the intervention.

Keywords: nutrition education hiv plhiv intervention knowledge. attitude, practices
a pilot study of non-invasive brain stimulation to boost the efficacy of psychotherapy in a community sample of people who drink alcohol

Conditions: Alcohol Use Disorder

Summary: the goal of this small (n=75) proof-of-concept randomized clinical trial is to test the effects of transcranial alternating current stimulation (tacs) during motivational interviewing (mi) sessions with participants who drink at above the low-risk level. participants will be randomized to receive either mi with active stimulation, mi with sham stimulation, or a delayed treatment group that receives mi with no stimulation. measures will include brain imaging, alcohol use, cannabis use, risk-taking behavior, emotions, and others. participants who are randomized to the delayed-treatment group will not receive brain imaging.

this proof-of-concept randomized clinical trial will recruit n=75 people with problematic levels of drinking who are considering treatment for their alcohol use. these participants will be randomized to one of three conditions: a condition that applies active tacs during an mi session (mi+tacs), a condition that applies sham stimulation during an mi session (mi+sham), or a waitlist control condition (mi-only). only participants the mi+tacs and mi+sham conditions will be included in the brain imaging portion of the study. one month after their intervention session, all participants will report their use of alcohol in the prior 30 days via an online assessment battery. this will allow us to test the effects of tacs on within-session client speech and outcomes. participants will have magnetoencephalography (meg) scans including rest and an alcohol cue task to measure the acute effects of brain stimulation. participants will also have mri scans including structure and rest. the motivational interviewing skill code (misc 2.5) and the casaa application for coding treatment interactions (cacti) will be used to assess counselor and participant speech in the recorded mi sessions and to ensure that sessions comply with the principles of mi.

Eligibility criteria:
inclusion criteria: * self-identify as having problem drinking * right-handed * age 21-60 years * audit score indicating risky drinking exclusion criteria: * left-handed or ambidextrous * currently engaged in treatment for alcohol use disorder * receiving treatment for alcohol use disorder within the prior 12 months * history of brain injury or neurological diagnosis * evidence of current psychosis * past-year substance use disorder other than alcohol, marijuana, or nicotine * current or history of severe alcohol withdrawal * mri/tacs contraindications including pregnancy * impaired hearing (psychotherapy using american sign language is not possible within the scope of the proposed study) * insufficient corrected visual acuity to complete the assessment instruments * unable to read/speak english fluently * unable to provide valid informed consent

Keywords: alcohol use disorder motivational interviewing transcranial electrical stimulation alcohol drinking