Kornimate/medical-research-clean huggingface dataset:
intensive outpatient services for teens

Conditions: Depression; Suicide

Summary: this study will identify the effectiveness of an intensive treatment program for teens who are at high risk for harming themselves.

suicidal ideation and behavior are the primary reasons for emergency psychiatric care and inpatient psychiatric hospitalization in this country. these expensive contacts with the health care system effectively address acute suicidality for many adolescents but there is a significant subset of suicidal patients that have continued suicidality. this study will target teens that are at risk for re-hospitalization based on continued suicidal ideation, their mood and another risk factor such as self-harm or substance use. these risk factors have been shown to increase risk for continued suicidal behavior and expensive contacts with the health care system. this protocol has been designed to determine whether intensive cognitive behavioral therapy (cbt), which was designed to treat adolescents with a mood disorder, suicidal ideation, and substance use, will result in better treatment outcomes compared to standard care in the community. the intensive cbt condition will be delivered by a team of two licensed mental health therapists over the course of one year and will work with both the teen and parent. the standard care condition will receive treatment in the community. one hundred-and fifty adolescents (38 a year) will be recruited from several inpatient and partial hospital locations. each adolescent will receive a thorough baseline assessment to determine whether they are appropriate for the study and will be assigned to either the intensive cbt condition or treatment within the community. both groups of teens will receive follow-up assessments at 6, 12, and 18 months to identify how they are doing over time.

Eligibility criteria:
inclusion criteria: * current mood disorder and suicidal ideation and one of the following * nssi * suicide attempt * substance use exclusion criteria: * intelligence quotient \< 80 * diagnosis of psychotic disorder, pervasive developmental disorder, obsessive-compulsive disorder, bulimia nervosa or anorexia nervosa * adolescent use of illicit "hard" substances such as cocaine, heroine, and opiates 13 or more times over the prior 90 days

Keywords: suicide attempt suicidal ideation nssi substance use
effectiveness of intranasal versus intravenous fentanyl in preterm and term newborns for pain prevention

Conditions: Pain

Summary: neonatal intensive care unit patients undergoes many painful procedures during their hospitalization. effective pain control in such procedures as intubation, catheterization, central line insertion, chest tube insertion, etc. is an important part of treatment. opioids administration is a common practice for acute pain prevention. fentanyl is the preferred opioid due to it rapid onset and short duration of action. fentanyl may be given intravenously, transcutaneous transmucosal and intranasal. intranasal administration is practiced for about 20 years. a rich vascular supply in a nose provides rapid absorption of the drug. this uninvasive root is now popular for pain prevention and treatment. there are about 20 trials with intranasal fentanyl administration to children from 6 month old to 18 years. the investigators did not find information about this way of administration in neonates. in our pilot study the investigators want to check if intranasal administration of fentanyl is safe and effective in pain prevention in term and preterm neonates during invasive procedures and to compare it with intravenous route of administration.


Eligibility criteria:
inclusion criteria: term and preterm neonates that require invasive procedures (elective or semielective intubation, central line insertion , chest drain or abdominal drain) exclusion criteria: 1. neonates with prolonged analgesic treatment before the procedure 2. neonates with neurologic problem which can interact with pain assessment

Keywords: intranasal fentanyl newborn
development of diabetes mobile application

Conditions: Type 2 Diabetes Mellitus

Summary: this study is to measure the effectiveness of a diabetes mobile application for improving patient's knowledge, compliance and diabetes control among uncontrolled type 2 diabetes mellitus mellitus patients in kedah

specific objective 1. to develop and validate a diabetes mobile-app (myd-app) for patients with uncontrolled type 2 diabetes mellitus. 2. to measure the effectiveness of a diabetes mobile application for improving knowledge, compliance and control using the newly developed and validated myd-app among patients with uncontrolled type 2 diabetes mellitus. hypothesis 1. there is an increased in patient's knowledge on diabetes after myd-app usage. 2. there is an increased in patient's compliance on medication and treatment after myd-app usage. 3. there is a diabetes control improvement (hba1c \< 6.5% or hba1c reduction ≥ 1%) among type 2 diabetes mellitus patients in kedah after myd-app usage.

Eligibility criteria:
inclusion criteria: * age 18-80 years old * diagnosed with type 2 diabetes mellitus by a registered medical doctor. * registered and actively follow up in the health clinics at selected districts. (actively follow up: follow up at the clinic for at least once in a year). * own a smartphone with the android platform. * hba1c \>7% exclusion criteria: * gdm * illiterate * anemia / thalassemia * not agree to be the sample for the study
dapagliflozin in type 2 diabetes mellitus patients (t2dm) with nonalcoholic fatty liver disease (nafld)

Conditions: Nonalcoholic Fatty Liver Disease; Type 2 Diabetes

Summary: the aim of this study is to evaluate the effect of dapagliflozin on liver function of patient with nafld and t2dm.

1. ethical committee approval will be obtained from ethics committee of faculty of pharmacy, damanhour university. 2. ethical committee approval will be obtained from ethics committee of general organization for teaching hospitals and institutes. 3. about 50 patients who are candidate to detect the hepato-protective effect of dapagliflozin on non- alcoholic fatty disease, will be recruited from alexandria teaching hospital (el-mery), general organization for teaching hospitals and institutes. 4. all participants should agree to take part in this clinical study and will provide informed consent. 5. demographic data; age (year), sex (female/male), weight (kg), height (cm), bmi (kg/m2) will be collected. 6. venous blood samples (5 ml will be collected by a sterile syringe then placed in a suitable sterile tube to be centrifuged, the serum will be reserved and stored at -80°c until the analysis) before, and after receiving medication (dapagliflozin). 7. measuring outcome: 1. the biochemical tests will be done on the patients are alanine aminotransferase (alt), aspartate aminotransferase (ast), homeostasis model assessment of insulin resistance (homa-ir), hemoglobin a1c (hba1c), low-density lipoproteins (ldl), high-density lipoproteins (hdl), triglycerides (tg), liver fibrosis score, and complete blood count (cbc). 2. the molecular tests will be done on the patient are soluble vascular cell adhesion molecule-1 (svcam-1), adipocytes (e.g. adiponectin, leptin). 8. the ultrasound screening will be done at first examination. 9. statistical tests appropriate to the study design will be conducted to evaluate the significance of the results. 10. results, conclusion, discussion and recommendations will be given.

Eligibility criteria:
inclusion criteria: 1. type 2 diabetes mellitus patients. 2. hba1c \< 8.5. 3. patients were they were having fatty liver changes on abdominal ultrasound and mild to moderate elevation of serum liver enzymes. 4. bmi more than 30 exclusion criteria: 1. patients with a history of alcohol, smoking, uncontrolled diabetes. 2. (hba1c \> 9.0). 3. pregnancy. 4. lactation. 5. hemochromatosis. 6. thyroid disorders. 7. renal dysfunction. 8. cardiac problem. 9. chronic liver and decompensated liver disease in the form of hepatitis b and c.
effects of inspiratory muscle training on stroke rehabilitation outcomes

Conditions: Stroke

Summary: this study is designed to explore the effects of a 4-week protocol of inspiratory muscle training (imt) at 50% maximum inspiratory pressure (mip) on respiratory function, diaphragm thickness, balance control, exercise capacity, and quality of life in people after stroke. to ascertain the effect of imt on the relationship between diaphragm muscle contraction and activation of other trunk muscles, this study also explores whether any effect of the 4-week imt protocol on balance control is associated with changes in the anticipatory posture adjustments (apas) time - the onset time of postural muscles during a required task (e.g., the rapid shoulder flexion test).


Eligibility criteria:
inclusion criteria: * age ≥ 40 years and \< 80 years; * breathing spontaneously; * clinically diagnosed with ischemic and/or haemorrhagic stroke; * duration of stroke from onset falls within 1 month to 12 months after diagnosis; * no thoracic or abdominal surgery within the last 6 months; * able to understand and follow verbal instructions; * no facial palsy, or mild facial palsy without limitation of labial occlusion; * able to maintain a resting sitting posture without feet support for at least 30 seconds; * no cognitive impairment (montreal cognitive assessment (moca) score ≥ 26); * able to independently walk at least 10 meters with or without an assistive device. exclusion criteria: * acute myocardial infarction or acute heart failure; * acute pain in any part of the body; * with respiratory illness or positive clinical signs of impaired respiratory function (such as shortness of breath, hypoxemia, chronic cough and sputum retention); * with chronic cardiovascular dysfunction; * trunk impairment scale (tis) score ≥ 20. * patient with a nasal feeding tube, tracheal tube and/or any condition that prevents the measurement or the implementation of the study procedure.

Keywords: stroke inspiratory muscle training diaphragm balance control exercise capacity quality of life anticipatory postural adjustment time
a p300 brain computer interface keyboard to control assistive technology for use by people with amyotrophic lateral sclerosis

Conditions: Amyotrophic Lateral Sclerosis

Summary: people with amyotrophic lateral sclerosis (als) will use a p300 based brain computer interface (bci) keyboard to type in assistive technology devices. the results of this study will be compared with a previous study of a p300 bci keyboard used by healthy volunteers.


Eligibility criteria:
inclusion criteria: * age 18 or older. * diagnosed with cerebral palsy, spinal cord injury, neuromuscular disease, or als that results in impaired hand and arm function making it difficult to manipulate objects (if at all) and requires help to prepare or modify activities * able to see the bci display * able to give informed consent * able to understand and remember instructions concerning participation * able to communicate effectively at least with familiar conversation partners exclusion criteria: * are unable to give informed consent. * are currently experiencing open head sores * have a history of photo-sensitive epilepsy * have a history of cognitive deficits requiring accommodation or special education services * are unable to sit without moving the head and neck for at least 15 minutes
exercise and weight control

Conditions: Overweight; Obese

Summary: the purpose of this study is to research the effects of exercise on calories eaten and expended. the investigator expects to find out whether subjects change their eating and activity behaviors when starting an exercise program.


Eligibility criteria:
inclusion criteria: * 18 to 40 years old * bmi of 25.0 - 35 kg/m2 * willing to consent to study conditions * not taking medications that affects energy expenditure or eating * not using tobacco or nicotine products * no food allergies or limitations to eating certain food that would prohibit them from eating the study foods * not be dieting to lose weight * no major health problems * cannot have known cardiovascular, pulmonary or metabolic disease * cannot be regularly exercising in an aerobic manner more than twice per week * must have a liking of at least 5 out of 10 for 75% of the study foods exclusion criteria: * \ 40 years old * bmi \ 35 kg/m2 * currently pregnant or trying to become pregnant, or lactating * currently using tobacco or nicotine * taking medication that affects energy expenditure or eating * food allergies to foods used in the study * regularly exercising in an aerobic manner more than twice per week * major health problems

Keywords: obese overweight exercise energy expenditure differences relative reinforcing values (rrv) food physical activity biological neurobehavioral behavioral
effectiveness of a condensed functional restoration program for patients with chronic low back pain: a study of 193 patients

Conditions: Low Back Pain

Summary: the aim was to assess the effectiveness of a condensed functional restoration program (cfrp) for patients with chronic low back pain and professional activity. methods: longitudinal 1 to 3 months study of patients with non-specific chronic low back pain in one tertiary care hospital, participating in a cfrp (complex interprofessional intervention over 4 days). the primary outcome was the oswestry disability index (odi) (0-100 scale). secondary outcomes included pain, quality of life (eq5d), patient acceptable symptom state, presenteeism, absenteeism and psychological distress (hospital anxiety and depression scale). outcomes were compared using paired sample student's t-test or chi2 between baseline and last follow-up. logistic regression was used to identify factors associated with better response (improvement of odi higher than 12.8) and included baseline demographic, psychological and physical assessment variables.


Eligibility criteria:
inclusion criteria: * non-specific clbp (\>3 months) with or without radicular pain, not currently in prolonged sick leave, no current indication for surgery, fluent in french, difficulties to maintain daily physical activity due to lbp with oswestry disability index and lumbar and radicular pain at baseline and at end of intervention or 3-month follow-up available. exclusion criteria: * specific lbp and organic contraindication to physical exercise.
hair up prospective study

Conditions: Hair Loss

Summary: the objective of this study is to assess the performance of hair up on female pattern hair shedding and regrowth. 58 adult female patients suffering from hair loss will be evaluated in a single center prospective study


Eligibility criteria:
inclusion criteria: * women who report hair loss during the past 3 months prior to the study exclusion criteria: * disorders and medications affecting hair loss/growth, pregnancy, scarring alopecia
hepatopulmonary syndrome and postoperative complications after liver transplantation : a case-control study

Conditions: Hepatopulmonary Syndrome; Liver Cirrhosis

Summary: hepatopulmonary syndrome is a respiratory complication of liver cirrhosis defined as a triad: hypoxemia (pao2 \< 80 mmhg in room air), chronic liver disease and intrapulmonary vasodilatations. its prevalence varies between 4 and 32%. numerous treatments have been tried but the only efficient therapy to cure the syndrome is liver transplantation. without transplantation it is associated with a higher mortality which is the reason why hepatopulmonary syndrome patients have a higher priority to transplantation. however it appears in some restricted studies that hepatopulmonary syndrome is associated with more postoperative complications (infections, vascular and biliary complications, prolonged length of mechanical ventilation...). the investigators hypothesised that hepatopulmonary syndrome patients have more postoperative complications after liver transplantation than non hepatopulmonary syndrome patients matched on age, meld (model for end-stage liver disease) score, comorbidities, perioperative transfusion and noradrenaline doses.


Eligibility criteria:
inclusion criteria: * liver transplanted patients exclusion criteria: * living donor transplantation * bipartition transplantation * non-heat-beating donor transplantation * minor * double or multiple organ transplantation * non cirrhotic patients * retransplantation

Keywords: liver transplantation hepatopulmonary syndrome liver cirrhosis
diagnosis of neurological fetal anomalies

Conditions: Fetal Anomaly of Central Nervous System

Summary: this is a descriptive cross-sectional study 300 patients coming for antenatal care at sohag governorate undergo mid anatomical scan. samples 300 pregnant women have mid anatomical scan at 20-22 weeks as routine antenatal care and examination of the fetal cns will be performed with a high resolution two dimensional ultrasound machine (voluson e8) equipped with a rab 4 to 8mhz multifrequency transabdominal probe. four standard recommended views-transventricular, falx, cavum, and posterior fossa or transcerebellar views-provide an overview of fetal intracranial anatomy during the second trimester anatomy scan. follow-up information will be obtained in all cases, and all infants will be considered healthy by pediatric examination. in selected cases, postnatal single-shot fast spin-echo magnetic resonance (mr) imaging will be performed as integrated, complementary investigation.to confirm diagnosis.

1. type of the study: this is a descriptive cross-sectional study 2. study setting: 300 patients coming for antenatal care at sohag governorate undergo routine second trimester scan. 3. patients and methods: inclusion criteria: 1. all pregnant females of 18 to 45 years old. 2. gestational age of 20- 22 gestational week . exclusion criteria: 1-age less than18years and more than 45 years. gestational age less or more than20- 22 weeks. samples methods 300 pregnant women low risk pregnancy will be scanned at 20-22 weeks as routine antenatal care and examination of the fetal cns will be performed with a high resolution two dimintional ultrasound machine (voluson e8) equipped with a rab 4 to 8mhz multifrequency transabdominal probe. four standard recommended views-transventricular, falx, cavum, and posterior fossa or transcerebellar views-provide an overview of fetal intracranial anatomy during the second trimester anatomy scan. follow-up information will be obtained in all cases, and all infants will be considered healthy by pediatric examination. in selected cases, postnatal single-shot fast spin-echo magnetic resonance (mr) imaging will be performed as integrated, complementary investigation.to confirm diagnosis.

Eligibility criteria:
inclusion criteria: * all pregnant females of 18 to 45 years old. * gestatioal age of 20- 22 gestational week . exclusion criteria: * age less than18years and more than 45 years. * gestational age less or more than20- 22 weeks.

Keywords: sonography ,neurlogical anomalies
impact of preop video on patient anxiety

Conditions: Prolapse, Vaginal; Prolapse, Uterine; Prolapse; Female

Summary: to determine whether a pre-operative educational video has an impact on the anxiety of patients undergoing vaginal prolapse surgery


Eligibility criteria:
inclusion criteria: * prolapse surgery may include: apical repair with uterosacral ligament suspension, or sacrospinous/iliococcygeal ligament fixation, or sacrocolpopexy. * they may also have a concomitant total vaginal hysterectomy with or without bilateral salpingectomy/oophorectomy, other compartment repairs for prolapse, or a suburethral sling for incontinence. * surgery by one of the fellowship trained urogynecologists at trihealth * age \>= 18 * english speaking * able to comprehend and answer the survey completely. exclusion criteria: * concomitant procedure with another surgeon * resides in a nursing home * non-english speaking * patients with mental disability, alzheimer's disease, dementia that would preclude complete answering of the survey or inability to answer the questions.

Keywords: anxiety video prolapse urogynecology
anti infective agents impact in covid-19 pneumonia

Conditions: COVID; Pneumonia, Viral

Summary: during covid-19 epidemic, hydroxychloroquine was proposed and authorized as a possible key agent in the treatment of covid-19 hospitalized pneumonia, including in france. gautret et al. proposed the combination regimen with azithromycin. however only one study reported the interest of azithromycin alone. retrospective study reporting the impact of the anti-infective agents used during the pandemic in a tertiary care hospital, using azithromycin with or without hydroxychloroquine.


Eligibility criteria:
inclusion criteria: * aged over 18 years old * hospitalized for a covid-19 pneumonia documented by pcr or lung tomodensitometry, * admitted outside an intensive care unit, in a medicine ward exclusion criteria: * patient opposed to data collected, or who could not consent because of a serious presentation of the pneumonia

Keywords: azithromycin hydroxychloroquine covid-19 pneumonia hospitalization
clinical precise diagnosis and treatment in the kawasaki disease

Conditions: Kawasaki Disease

Summary: the purpose of this project is to explore the differential gene expression profile of kawasaki disease, and will explore the diagnosis and treatment targets related to coronary artery injury or kawasaki disease susceptibility, vascular damage, ivig (intravenous immunoglobulin) treatment resistance, incomplete kawasaki disease, etc.

after being informed about the study and potential risks, all patients giving written informed consent will acquire blood samples with complete clinical data and prognostic information. using clinicopathology, molecular biology, gene diagnostics and other techniques to verify the expression differences of target genes and proteins and analyze their expression levels; to analyze the role of target genes and proteins in the occurrence and development of kawasaki disease and their correlation with the risk of coronary artery injury. in vitro and in vivo kd (kawasaki disease) model was used to investigate the role of target genes in kawasaki disease by gene interference and various molecular biological techniques.

Eligibility criteria:
inclusion criteria: * individual patient's medical file data confirmed the diagnosis of kd using diagnostic criteria issued by the american heart association in 2017; * patients were respond to ivig treatment; * the patients aged from 2 months to 14 years old; * all included patients required to sign an informed consent form. exclusion criteria: * the patients with severe infections; * the patients with a history of tuberculosis or recent close contact with tuberculosis; * the patient vaccinated with live vaccine in 6 months; * the patients with the application of hormone or other immunosuppressive agents; * the patients didn"t want to signed informed consent.
physical exercise and coronary artery plaque composition

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to examine the effect of two different physical exercise protocols on changes in coronary artery plaque composition and development of in-stent restenosis in patients treated with percutaneous coronary intervention with stent implantation. the investigators will compare aerobic interval training and moderate continuous training. both exercise protocols have a duration of 12 weeks. the investigators hypothesize that aerobic interval training is superior to moderate continuous training regarding effects on the composition of coronary artery plaques and a reduction in the development of in-stent restenosis.


Eligibility criteria:
inclusion criteria: * stable or unstable coronary artery disease treated with percutaneous coronary intervention with stent implantation, * informed patient consent exclusion criteria: * st-elevation myocardial infarction, * inability to give informed consent, * inability to participate in regular training due to residency, work situation or comorbidity, * any known chronic inflammatory disease other than atherosclerosis, * planned surgery within the next four months