effects of channa striata extract on intestinal inflammation and nutritional status in malnutritional toddlers after albendazole therapy in south bangka district

Conditions: Malnourished Children

Summary: the goal of this clinical trial is to learn if intervention with channa striata extract or inbumin forte sachet as a food supplement can improve intestinal damage and nutritional status in malnourished children aged 1.5-5 years. the main questions it aims to answer are: * whether there is a change in calprotectin and aat levels after administration of snakehead fish extract of inbumin forte sachet? * whether there is a difference in changes in nutritional status after administration of snakehead fish extract or inbumin forte sachet? researchers will compare snakehead fish extract or inbumin forte sachet to a placebo (a look-alike substance that contains no drug) to see if snakehead fish extract or inbumin forte sachet works to treat children malnutrition. participants will take snakehead fish extract or inbumin forte sachet or placebo every day for 3 months. researchers will visit study participants every month to check their weight and height and monitor vitamin administration through photos, notes and videos sent every day and records complaints or symptoms that may arise and at the end of 3 months, researchers will collect stool and blood samples and check nutritional status.

the study participants were malnourished children aged 1.5 to 5 years. data on malnourished children were obtained from the local health department. based on this data, participants were selected from several sub-districts with the highest malnutrition cases, including toboali (rias and toboali villages), payung, air gegas, and batu betumpang sub-districts. after invitations were sent to the participants, they were registered using their family registration card and assigned a queue number or research code. the study plan and research procedures were then explained to the participants. first, anthropometric measurements were conducted including weight and height, with the results entered into the who anthro calculator (-3 sd to \ 0.05. normally distributed data were presented as mean and standard deviation, while non-normally distributed data were shown as median and range (minimum-maximum). bivariate analysis was conducted to determine whether there were significant differences in nutritional status, macronutrient and micronutrient levels, inflammatory markers, intestinal permeability, and gut microbiota between children receiving striatin protein supplementation and those receiving a placebo. a paired t-test was used if the data were normally distributed to analyze mean differences between the two groups. if the data were not normally distributed, a chi-square test or mann-whitney test was applied. the effect of striatin protein intake on the studied variables was assessed using linear regression analysis. the hypothesis test results were interpreted at a 95% confidence level (α = 0.05), with the null hypothesis (h₀) being rejected if p \< 0.05.

Eligibility criteria:
inclusion criteria: * malnourished children aged 1.5-5 years (-3sd to \< -2 sd) * parents or guardians are willing to participate in the study * parents or guardians can read and fill out the questionnaire exclusion criteria: * children with chronic diseases such as tuberculosis, congenital heart disease, diabetes, cancer, epilepsy, hiv aids, sickle cell anemia, and mental illness. * children with history of snakehead fish allergy * children with physical disabilities that complicate data collection

Keywords: snakehead fish extract malnourished children calprotectin striatin