Kornimate/medical-research-clean huggingface dataset:
preoperative hemoglobin and acute kidney injury in emergency surgery

Conditions: Emergency Surgery; Acute Kidney Injury; Hemoglobin

Summary: optimization of hemoglobin levels for organ perfusion is essential, especially in critically ill patients. although anemia is associated with severe organ failure, especially in coronary artery disease, the effects of blood transfusion or various interventions to increase hemoglobin levels on outcomes continue to be debated. the effects of hemoglobin levels in emergency surgery patients on the development of postoperative aki have been investigated in a small number of studies in the literature, and clear results have not yet been reported. this study was designed to evaluate the effect of hemoglobin levels on the development of aki after adjustment for known predictive factors.

acute kidney injury (aki) is a common complication in patients undergoing major surgery and is associated with both short-term morbidity and mortality and long-term adverse outcomes including the development of chronic kidney failure. optimization of hemoglobin levels for organ perfusion is essential, especially in critically ill patients. although anemia is associated with severe organ failure, especially in coronary artery disease, the effects of various interventions such as blood transfusion or increasing hemoglobin levels on outcomes continue to be debated. this prospective observational study was planned to evaluate the effect of hemoglobin levels before emergency surgery on the development of postoperative aki. emergency operated patients will be divided into two groups as group aki and group non-aki according to the development of postoperative renal failure. postoperative aki diagnosis and severity will be evaluated according to serum creatinine and/or urine output according to kdigo (kidney disease: improving global outcomes criteria). demographic characteristics of the patients, preoperative complete blood count, blood biochemistry characteristics, hemodynamic variables, fluid replacement, blood and blood product replacements, surgical characteristics, development and severity of aki in the postoperative period will be recorded and the effect of hemoglobin level on the development of aki will be evaluated.

Eligibility criteria:
inclusion criteria: * patients undergoing emergency non-cardiac surgery exclusion criteria: * known renal failure * need for reoperation within 48 hours postoperatively * exit status within 48 hours postoperatively * known hematological disease * known kidney transplantation * urgent surgery planned due to urinary system related diseases * patients who did not accept to participate in the study

Keywords: acute kidney injury emergency surgery risk factor hemoglobin
discontinuation of primary and secondary prophylaxis for opportunistic infections in hiv-infected patients

Conditions: HIV Infection

Summary: the purpose of this study is to compare the incidence of opportunistic infections between hiv-infected patients who continue and discontinue primary or secondary prophylaxis for opportunistic infections in whom receiving combination antiretroviral therapy and achieve undetectable hiv-1 rna, but cd4 cell counts are less than 200 cells/mm3.

currently, combination antiretroviral therapy (cart) has become the standard of care in the treatment of hiv infection in many parts of the world including thailand. the benefits of cart represented by an increment of cd4 cell count and a suppression of hiv viral load have been reported worldwide. the national institute of health (nih), the centers for disease control and prevention (cdc), and the hiv medicine association of the infectious diseases society of america (hivma/idsa) recommended discontinuing primary and secondary prophylaxis for prevention of opportunistic infections (ois) in hiv-infected adults and adolescents receiving cart, when the cd4 cell count increase to a certain level for a certain period of time. for instances, pneumocystis jiroveci pneumonia (pcp) prophylaxis can be discontinued when patients receiving haart and cd4 ≥ 200 cells/mm3 for at least 3 months (for primary prophylaxis) or at least 6 months (for secondary prophylaxis), prophylaxis for cryptococcal meningitis, disseminated penicilliosis, cerebral toxoplasmosis, and disseminated mycobacterium avium complex can be discontinued when patients receiving haart and cd4 ≥ 100 cells/mm3 for at least 6 months. our practices follow this guideline. however, recently there are new data showing that there were no cases developed pcp after primary or secondary prophylaxis discontinuation even if cd4 cell count \< 200 cells/mm3. discontinuation of secondary prophylaxis resulted in reduction in pill burdens that may improve haart adherence, decrease drug-drug interactions, and also prevent drug adverse events that may happen.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years old 2. regularly receiving highly active antiretroviral therapy (haart) during follow up 3. cd4 cell count \< 200 cells/mm3 4. hiv-1 rna \< 50 copies/ml after receiving haart 5. receiving primary or secondary prophylaxis for opportunistic infections including infections caused by pneumocystis jiroveci, cryptococcus neoformans, penicilliosis marneffei, histoplasma capsulatum, toxoplasma gondii, mycobacterium avium complex 6. given written informed consent exclusion criteria: 1) pregnancy

Keywords: primary prophylaxis secondary prophylaxis discontinuation
reduction of dentine hypersensitivity after use of different dentifrices

Conditions: Sensitivity, Tooth

Summary: to assess the impact of the use of 5% calcium sodium phosphosilicate or 8% arginine dentifrices on dentinal hypersensitivity following non-surgical periodontal therapy in patients with periodontitis.

to assess the impact of the use of 5% calcium sodium phosphosilicate or 8% arginine dentifrices on dentinal hypersensitivity following non-surgical periodontal therapy in patients with periodontitis. patients will be selected on the bases of inclusion and exclusion criteria.descriptive statistics will be presented for both qualitative and quantitative variables

Eligibility criteria:
inclusion criteria: 1. participants must be between 30 and 65 years old. 2. participants should be in good general health. 3. participants must have a diagnosis of generalized chronic periodontitis according to the 1999 classification definition. 4. participants should complain of at least two teeth with dentinal hypersensitivity. 5. participants must exhibit moderate to severe dentinal hypersensitivity (schiff's scores of 2 to 3) or tactile stimulation (visual analogue scale (vas) score \>4) after at least one scaling and root planing session. exclusion criteria: 1. individuals with dentinal hypersensitivity symptoms prior to periodontal treatment. 2. those who have used agents to treat hypersensitivity in the past 3 months. 3. participants who are allergic to the test products (5% csps or 8% arginine). 4. dentinal hypersensitivity caused by factors such as dental caries, defective restorations, fractured teeth, abrasion or abfraction, extensively restored teeth, or restorations extending into the test area. 5. individuals who have undergone orthodontic treatment within the past 3 months. 6. patients with crowded teeth or serving as abutment teeth for fixed or removable prostheses are also excluded from the study.
role of the chemical environment in the pathogenesis of inflammatory bowel disease

Conditions: Inflammatory Bowel Diseases

Summary: inflammatory bowel diseases (ibd) including crohn's disease and ulcerative colitis are multifactorial diseases leading to chronic inflammation of intestinal mucosa. their etiology is still unknown. recently, major advances in the understanding of their pathophysiology have allowed to define them as heterogenic polygenic diseases, occurring in genetically susceptible patients. however, the whole genetic susceptibility does not explain the development of ibd and several data argue in favor of the involvement of environmental factors, which remain to be identified. the aims of this clinical trial are: 1. as main objective: to determine the effects of environmental pollutants on intestinal homeostasis and particularly on inflammatory process and endoplasmic reticulum stress. 2. as secondary objective, to assess in human the genetic susceptibility of intestinal mucosa to environmental chemical compounds (i.e. xenobiotics), its interindividual variability, and its potential involvement in the pathogenesis of ibd.


Eligibility criteria:
inclusion criteria: 1. patients who are at least 18 years old 2. has crohn's disease or ulcerative colitis, diagnosed, confirmed by radiological and / or endoscopic examination within 4 years or "control" patient not suffering from inflammatory bowel disease (patient with abdominal pain and / or persistent diarrhea, or patient requiring coloscopy for cancer of the digestive tract diagnosis) 3. patients requiring coloscopy as part of their medical follow-up 4. social insured. exclusion criteria: 1. pregnant women 2. breastfeeding women 3. people in emergency 4. persons unable to understand, read and / or sign informed consent 5. patients who recently had an intercurrent episode (eg recent diarrhea ...) 6. persons deprived of their liberty 7. persons protected by a legal protection status

Keywords: environmental risk factors xenobiotic detoxification
retrospective study of airway management in dutch ed's

Conditions: Endotracheal Intubation

Summary: describing characteristics of the practice of airway management in dutch emergency departments, including information about patient demographics, indications, performer characteristics, equipment and medication used and complications due to intubation.

endotracheal intubation can be a lifesaving intervention for critically ill patients in the emergency department (ed). endotracheal intubation is, however, a high-risk procedure with many potential complications, which seem to be even more prevalent when carried out in the ed compared to for example the operating theater. this is possibly due to multiple reasons such as a sicker population, non-elective setting, a higher variability among indications for intubation or competence of providers. internationally, large registries were established and multiple observational studies have been performed to gain more information about the methods, safety and complications of intubations in the ed. while in recent years these studies have added to our knowledge of ed airway management, there is still a lack of high-quality studies and there is a strong argument for increased research. to date, no studies have been published of airway management in dutch eds. the investigators therefore have no knowledge about any factors possibly influencing intubation outcomes and complications nor comparability with international data. among these are factors that have been associated with preventable harm and death and insight into these factors could be used for improvement of the safety of airway management in dutch eds. this study is therefore intended to provide a comprehensive review of the clinical practice and characteristics of endotracheal intubations within dutch eds. the results could potentially be used for comparative analysis against global datasets. additionally, the insights gained from this study will shed light on existing gaps prevalent in the current registration processes of intubations in the netherlands. furthermore, these insights could act as a stepping stone for future investigations that can lead to a deeper understanding of the methodologies, safety protocols, and associated complications of endotracheal intubations within dutch eds

Eligibility criteria:
inclusion criteria: * all patients who underwent endotracheal intubation between 01-01-2019 and 31-12-2023 in the participating ed's exclusion criteria: * patients for which no information about the intubation can be found in the electronic patient chart will be excluded from the study.
premom-ii: pregnancy remote monitoring of women with gestational hypertensive disorders

Conditions: Gestational Hypertension

Summary: the goal of this project is thoroughly evaluate the added value of telemonitoring (tm) program for women at risk for gestational hypertensive disorders (ghd), by investigating it impact on prenatal follow-up, health outcomes for mother and child, costs and satisfaction, and by specifically investigating what are the major contributors to this added value. a substudy (caprom) will be conducted at the department of obstetrics \& gynecology at ziekenhuis oost-limburg (zol) in collaboration with the department of physiology of hasselt university in the framework of the limburg clinical research center (lcrc). caprom aims at evaluating the relationship between longitudinal (clinical) blood pressure measurements and changes in (subclinical) cardiovascular (cv) hemodynamics throughout pregnancy, as well as their responses to antihypertensive medication. to this end, cv profiling will be performed longitudinally on pregnant women at risk for developing ghd being included in the tm group of the premom ii study (group 1) or being followed-up via tm as part of their usual care (group 2). a separate icf is signed for inclusion in the caprom substudy. the results of the caprom study will be performed by a researcher who is not involved in the premom ii main study. in addition, results of the cv profiling will not be communicated to the clinical decision makers of premom ii.


Eligibility criteria:
inclusion criteria: * a risk \> 1/100 on the fetal medicine foundation (fmf) tool, which is used from the following website: https://fetalmedicine.org/research/assess/preeclampsia/first-trimester * caprom substudy: pregnant women at risk for the development of ghd being followed-up via tm as part of the premom ii study (group 1) or usual care (group 2) exclusion criteria: * congenital malformations of the newborn, * pregnant women who doesn't have a smartphone, * pregnant women \< 18 years old, * pregnant women who doesn't understand the dutch/french/english language. -

Keywords: remote monitoring gestational hypertensive disorders pregnancy outcomes
breast cancer patients: a breast cancer rehabilitation and exercise laboratory

Conditions: Early Stage Breast Cancer (Stage 0-III)

Summary: the proposed study compares the outcomes of a physical activity intervention begun at diagnosis, continuing through active cancer treatment and into six months of survivorship compared to the outcomes of a control group receiving limited information on activity.

patients (with stage 0 to stage iii breast cancer)receiving chemotherapy, radiation or both chemotherapy and radiation will be included in the study.randomization will be stratified by disease stage at diagnosis, treatment modalities planned, and hormonal status. each patient will have a weekly goal of 2000 calories burned and 18 met-hours of exercise which can be achieved in 4 to 7 hours of physical activity per week. resistance training, using weight machines and aerobic training using treadmills, elliptical trainers and stationary bicycles, will be utilized in the intervention group. the control group will receive basic information on physical activity but not be instructed. any physical activity in this group will be self-reported. change in c-reactive protein will be the primary endpoint. changes in other laboratory values, dexa measurements, and quality of life measurements will be secondary endpoints.

Eligibility criteria:
inclusion criteria: 1. consent to participate in study 2. women aged 18 and older 3. stage 0 to iii breast cancer prior to any treatment and at time of diagnosis 4. requires treatment that includes chemotherapy, radiation therapy or both chemotherapy and radiation therapy 5. adequate fitness to participate in a physical activity as assessed by the investigator 6. willing and able to participate in a prescribed exercise program exclusion criteria: 1. metastatic breast cancer (stage iv) 2. initiation of treatment regimen prior to enrollment 3. treatment for breast cancer not requiring chemotherapy or radiation therapy 4. patients who are pregnant (negative urine pregnancy test required at baseline to determine eligibility in women of child bearing potential). 5. currently lactating 6. do not read, understand, or speak english eligible participants will not be included if they have: 1. known cardiac disease, 2. uncontrolled hypertension, 3. uncontrolled thyroid disease, 4. diabetes mellitus, 5. mental illness, 6. infection, 7. immune or endocrine abnormality, 8. body weight reduction i10% in past 6 months, and 9. positive exercise stress test. 10. major surgery within last 6 months that requires exercise restriction

Keywords: breast cancer exercise crp c-reactive protein bmi nevada cancer institute rehabilitation prescriptive exercise physical activity dexa obesity lifestyle intervention early stage breast cancer patients (stage 0-iii)
surgical intervention for the treatment of diabetes in overweight non-responders-1

Conditions: Overweight; Diabetes Mellitus, Type 2

Summary: the sit-down study is a single centered retrospective study in which a total of 90 (ninety) participants who are overweight (bmi: 25-29.9 kg/m2) and have type 2 diabetes mellitus (t2dm) will be evaluated for the efficacy of surgical intervention in comparison with medical treatment. primary endpoint of the study will be the change in glycemic regulation by the end of 12 months.

use of bariatric/metabolic surgery has conventionally been reserved for those whose body-mass index (bmi) is 35 kg/m2 or greater. trials in these morbidly obese patients confirmed the benefits in terms of weight loss and provide evidence that surgery can result in remission of diabetes, and as a result lead to improvement in cardiovascular risk factors. within the light of these data, there appear to be a shift towards lower bmi, with many advocating it as a reasonable option for diabetics with a lower bmi (\<30) who have failed other attempts of medical treatment. but this approach is limited because of lack of data on the effects of surgical outcomes in this group of patients which is the main rationale for this retrospective study.

Eligibility criteria:
inclusion criteria: * overweight, type 2 diabetic: type 2 diabetes diagnosis longer than 3 years; bmi= 25-29.9 kg/m2 * participants with baseline hba1c ≥ % 7.5, not achieved hba1c \< % 7.3 at 3 months on therapy * absence of co-morbidities (neuropathy, retinopathy, cardiovascular disease, stroke events or lower extremity amputation). exclusion criteria: * liver cirrhosis, severe renal failure, collagen diseases, severe endocrinopathies, blindness. * heart failure, acute myocardial infarction, stroke or transient ischemic attack, unstable angina pectoris. * history of malignancy or malignant neoplasm in place, severe inflammatory complications, neurological or cardiovascular in act. * pregnancy * any conditions that at the discretion of the head of the study can represent risk to the participant or could affect the protocol results.

Keywords: type 2 diabetes metabolic surgery medical treatment
a phase 1 study of hrs8807 monotherapy and in combination with shr6390 in subjects with er-positive, her2-negative metastatic or locally advanced breast cancer

Conditions: ER-Positive, HER2-Negative Breast Cancer

Summary: the study is to assess safety and tolerability of hrs8807 monotherapy and in combination with shr6390 in subjects with metastatic or locally advanced breast cancer in order to estimate the dose-limiting toxicity (dlt), maximum tolerated dose (mtd) and select the recommended phase 2 dose (rp2d).


Eligibility criteria:
inclusion criteria: 1. histological diagnosis of metastatic or locally advanced breast cancer; histologically proven diagnosis of er-positive, her2-negative; 2. at least 1 line of endocrine therapy in the metastatic or advanced setting that had progressed or intolerance; ≤ 2 lines of chemotherapy for metastatic or advanced disease; 3. eastern cooperative oncology group (ecog) performance status (ps) 0 or 1; 4. expected survival of more than 3 months. exclusion criteria: 1. all patients in monotherapy and or in combination wih phase who are known allergic to hrs8807 or shr6390 ingredient; 2. presence of symptomatic metastatic visceral disease ; 3. patients with known active brain metastases; 4. clinically serious cardiovascular disease; 5. abnormal electrocardiographic (ecg) with clinical significancy by investigator judgement; 6. abnormal thyroid function laboratory results; 7. active infection or unexplained fever \>38.5℃ during screening period or on the day of the first dose.
residential cognitive and interpersonal therapy for social phobia

Conditions: Social Phobia

Summary: the purpose of this study is twofold: (1) to compare the effectiveness of two promising treatments for social phobia, a new cognitive therapy model (clark \& wells, 1995; borge et al., 2001) and interpersonal therapy (lipsitz, markowitz, \& cherry, 1997), adapted for inpatient groups; and (2) to study the empirical change processes in these therapies and compare them with the cognitive and interpersonal models of change.

social phobia typically leads to severe impairment in work and other social life, and - without treatment - it can persist for decades. given its prevalence, severity, and chronicity, effective treatment methods are strongly needed. however, traditional psychological and pharmacological treatments have had statistically significant, but clinically limited effects (taylor, 1996). based on an empirical analysis of the cognitive processes in social phobia, clark and wells (1995) have developed a new cognitive model. cognitive therapy (ct) derived from this model has been found to be superior to a combination of fluoxetine and self-exposure (clark et al., 2003). social phobic symptoms may be viewed as a result of more general interpersonal difficulties and interpersonal psychotherapy (ipt) can be a reasonable alternative for social phobia (lipsitz \& markowitz, 1996). a clinical case series indicates that social phobic patients improve during interpersonal psychotherapy for social phobia (ipt-sp; lipsitz et al., 1999.

Eligibility criteria:
inclusion criteria: * dsm-iv criteria for social phobia * the patient consider social phobia as the main current problem * willingness to suspend use of psychotropic medication, alcohol and other substances * acceptance of random allocation * ability to speak norwegian * age 18-65 years. exclusion criteria: * a history of recurrent major depression currently treated sucessfully with antidepressant medications * has immediate need for additional treatment * current psychotic disorder or substance abuse * organic mental disorder * previously treated with similar models

Keywords: social phobia cognitive therapy interpersonal therapy efficacy process-outcome
use of integrated pulmonary index monitorisation in children undergoing botulinum toxin injection

Conditions: Cerebral Palsy; Pediatric ALL

Summary: this study aimed to detect hypoxia early with ıntegrated pulmonary index monitoring compared to saturation.

this trial will be held at the kocaeli universty hospital. 75 children 4-17 years of age undergoing botulinum toxin injection with sedation will be enrolled in this prospective study. patients premedicated with midasolam iv 0.5 mg bolus and then sedated with propofol 1 mg/kg and fentanyl 0.5 mg/kg . integrated pulmonary monitoring and noninvasive capnograhy will be used. bis monitoring and spo2 monitoring will be applied. standard anesthesia monitoring including noninvasive blood pressure, spo2 , ekg and heart rate will be monitored. this trial aimed to detect hypoxia and apnea earlier than pulse oximetry.

Eligibility criteria:
inclusion criteria: * 4-16 age pediatrics * undergoing botilinum injection with sedation * asa 1-2 exclusion criteria: * \> 18 age * asa 3-4 * patients with upper respiratory tract infection

Keywords: botilinum toxin pediatrics ıntegrated pulmonary index hypoxia