Kornimate/medical-research-clean huggingface dataset:
text message nudges for covid-19 vaccination

Conditions: Covid19

Summary: the covid-19 pandemic has caused significant morbidity and mortality across the world. effective vaccines are now available but underutilized. in july 2021, ascension health implemented a mandate requiring all employees to obtain the covid-19 vaccine by november 12th. in august 2021, the number of covid-19 cases in the us increased rapidly, specifically in states with lower vaccination rates, many of which are served by ascension health facilities. in this study, we will evaluate a rapidly deployed health system initiative to use text messaging to nudge ascension employees who have not yet been vaccinated to commit to a date and receive vaccination.

the covid-19 pandemic has caused significant morbidity and mortality across the world. effective vaccines are now available but underutilized. in july 2021, ascension health implemented a mandate requiring all employees to obtain the covid-19 vaccine by november 12th. in august 2021, the number of covid-19 cases in the us increased rapidly, specifically in states with lower vaccination rates, many of which are served by ascension health facilities. nudges are subtle changes to the way information is framed or choices are offered that can have a significant impact on behavior. status quo bias is a preference for the current state which is often used as a reference point when making decisions. changes from the reference point are often faced with high inertia and this prevents changes in behavior. default options are the setting of the baseline reference point and are often taken as an implicit recommendation. in prior work, changing default options has led to significant changes in health-related behaviors. for example, changing prescription default settings in the ehr from opt-in to opt-out for generic prescriptions increased the rate of generic prescriptions from 75% to 98% across penn medicine (patel et al. annals of im. 2014; patel et al. jgim 2018). framing program participation as opt-out has led to a 22% increase in enrollment in a covid-19 surveillance testing program (oakes et al. nejm catalyst 2021) and triple enrollment in remote monitoring programs for medication adherence (mehta et al. jama cardiology. 2018) and diabetes management (aysola et al. ajhp 2016)

Eligibility criteria:
inclusion criteria: * ascension associate employee exclusion criteria: * prior vaccination for covid-19 * exemption from covid-19 vaccination
inverse ratio ventilation on bariatric operation

Conditions: Hypoxia

Summary: for evaluating inverse ratio ventilation of laparoscopic bariatric surgery

inverse ratio ventilation had been improve the oxygenation and respiratory mechanics during care of ards patients or during general anesthesia. we hypothized inverse ratio ventilatio could improve the oxygenation and respiratory mechanics on the obese patient also.

Eligibility criteria:
inclusion criteria: * asa ps 1-2 obese patients(bmi\>30) exclusion criteria: * underlying cardiopulmonary diasease
assessment of the aromatherapy to alleviate peri operative anxiety in ambulatory elective upper limb surgery under loco-regional anesthesia

Conditions: Anxiety

Summary: aroma study is a randomised controlled parallel-group single-site study. patients randomized in the experimental group benefit from the aromatherapy at their arrival in the operating theatre in the recovery room. 2 drops of essential oils are applied on a compress placed next to the head of the patient. this compress is kept until the patient is leaving the operating theatre. patients randomized in the control group don't benefit from the aromatherapy. the anxiety evolution is measured in both groups with the amsterdam preoperative anxiety and information scale (apais). the hypothesis is that aromatherapy alleviate peri operative anxiety during an ambulatory elective upper limb surgery under loco-regional anesthesia.


Eligibility criteria:
inclusion criteria: * patient admitted in hospital centre for an ambulatory elective upper limb " fast track " surgery * patient with loco-regional anesthesia * patient categorized 3 or less according to the american society of anesthesiologists (asa) score * the patient must have given his written consent to participate in the study * patient - insured under the french social security system * patient prepared to comply with all the terms of the study and its length exclusion criteria: * epileptic patients * asthmatic patients * patients with cognitive disorders ( mini mental status below 15) * psychiatric disorders : current depression or bipolar disease or anxiety disorders or psychotic disorders according to dsm-v classification * american society of anesthesiologists score strictly superior to 3 * preoperative chronic pain : neuropathic pain, fibromyalgia, polyarthritis * pregnant or breastfeeding woman * patient unable to receive an informed consent and to comply with all the terms of the study * patient without any social insurance * refusal to sign the consent * patient under legal protection * patient in emergency (unstable clinical state) * patient unable to read or write french * patient enrolled in an other clinical trial

Keywords: perioperative anxiety aromatherapy surgery loco-regional anesthesia ambulatory
nurse graduateness and patient outcomes: a cross sectional pilot study

Conditions: no Spedific Condition, All-cause In-patient Mortality

Summary: this research project is relevant to the identification of the relationship, and its significance, between patient morality and a number of demographic, clinical and corporate characteristics. two separate data sets have been compiled linking the existing intervention and employment data, one focusing on the admitting nurse and another one considering all the nurses involved in each intervention. several statistical experiments will take place to support or reject the main hypothesis: higher nurse education, satisfaction and staffing levels result to lower patient mortality.

the primary research objective is to investigate the relationship between the education, satisfaction and staffing level of the nurses and the mortality rate across hmc. the relationship between mortality will be investigated against some additional demographic characteristics of the patient and the nurses as well as a umber of clinical parameters like the length of stay and the severity of the interventions. to achieve that data will be retrospectively collected from the human resources database containing the nurse education and demographic information and will combine it to the intervention data coming from the clinical information systems of all major public hospitals in qatar excluding accident and emergency cases to avoid confounding. rigorous statistical analysis will be conducted to obtain the significance of this relationship within expected confidence intervals. the end result of that process is to find whether there is a significant positive or negative relationship between nurse education and mortality rate. for confounding purposes accident and emergency data have been excluded, we have performed several adjusted and unadjusted logistic regression tests and taking into consideration the clustering effect of the data.

Eligibility criteria:
exclusion criteria: * accident and emergency patients * records with negative length of stay * records with incorrect patient demographics
early detection of epstein-barr virus related disease.

Conditions: Post-transplant Lymphoproliferative Disorder; Mononucleosis; Epstein-Barr Virus Infections; Epstein-Barr Virus Related Malignancy; Epstein-Barr Viraemia; Epstein-Barr Virus-Related Hodgkin Lymphoma; Epstein-Barr Virus-Related Non-Hodgkin Lymphoma; Hemophagocytic Lymphohistiocytoses; Hemophagocytosis

Summary: epstein-barr virus (ebv) is one of several herpesviruses that cause disease in humans. ebv virus has an oncogenic potential, and it has been associated with the development of a wide range of cancers. previous studies have shown a close association between ebv and post-transplant lymphoproliferative disorder (ptld) in transplant recipients. as part of a preventive approach against ptld, several transplantation units now monitor the occurrence of ebv-dnaemia after transplantation. however, there is little evidence to guide this strategy; nor is there consensus concerning either the best specimen to use for ebv analysis (whole blood or plasma). in this study investigators aim to optimise and validate a polymerase chain reaction (pcr)-test for ebv-dna on, respectively, whole blood, plasma and a combination of plasma and lymphocytes. the investigators wish to determine which of the three tests best predicts current and future risk of development of ebv-related diseases such as mononucleosis and ptld.

ebv is one of several herpesviruses that cause disease in humans. primary ebv infection usually occurs in early childhood and is generally asymptomatic, while later infection may cause mononucleosis. as with other herpesviruses, primary infection is followed by persistent (lifelong) infection. ebv virus has an oncogenic potential, and it has been associated with the development of a wide range of cancers. previous studies have shown a close association between ebv and ptld in transplant recipients. as part of a preventive approach against ptld, several transplantation units now monitor the occurrence of ebv-dnaemia after transplantation. however, there is little evidence to guide this strategy; nor is there consensus concerning either the best specimen to use for ebv analysis (whole blood or plasma) or the appropriate clinical action to take if ebv-dnaemia is detected. in this study investigators aim to optimise and validate a polymerase chain reaction (pcr)-test for ebv-dna on, respectively, whole blood and a combination of plasma and lymphocytes. results obtained with the two new methods will be compared with those from the already established world health organization (who) standardised ebv-pcr test on ethylenediaminetetraacetic acid (edta)-plasma. the result of all three tests will be evaluated relative to ebv-related symptoms and other diseases. the investigators wish to determine which of the three tests best predicts current and future risk of development of ebv-related diseases such as mononucleosis and ptld.

Eligibility criteria:
inclusion criteria: * patients suspected for having ebv disease. exclusion criteria: * if the patients has any contraindications for blood sampling.
association between thyroid dysfunction and intensive care unit acquired weaknesss

Conditions: Thyroid Abnormalities; ICU Acquired Weakness

Summary: intensive care unit-acquired weakness (icu-aw) is the most common neuromuscular impairment in critically ill patients. it affects more than 50 % of patients in the intensive care and is related to many problems as difficult weaning from mechanical ventilation, prolonged hospital stay and increased mortality.thyroid disorders are also associated with neuromuscular abnormalities and may decrease the threshold for the development of any type of myopathy. however, no previous study investigated the direct relationship between thyroid dysfunction and icuaw.this study aims at evaluation of the association between thyroid dysfunction and intensive care unit acquired weakness.

intensive care unit acquired weakness refers to muscle weakness encountered in the intensive care unit as a consequence of critical illness. it affects more than 50 % of patients in the intensive care and is related to many problems as difficult weaning from mechanical ventilation, prolonged hospital stay and increased mortality. there are three distinct entities for icuaw that can only be differentiated by neurophysiological studies. these are critical illness myopathy (cim), critical illness polyneuropathy (cip) and critical illness neuromyopathy (cinm). identification of risk factors responsible for the development of icuaw is the first step in the prevention and management of this disorder. till time septic shock, hyperglycemia, high dose steroid therapy, prolonged mechanical ventilation and the use of neuromuscular blocking agents are the main accused. thyroid disorders are also associated with neuromuscular abnormalities. unfortunately, the prevalence of thyroid dysfunction in the intensive care is high reaching 90%. moreover, patients with severe critical illness, who are typically prone to the development of icuaw, show changes in their thyroid biochemistry namely low t3 levels (with or without low t4 levels) in the presence of normal tsh levels. these changes are collectively known as non-thyroidal illness syndrome (previously low t3 syndrome and euthyroid sick syndrome) which is the most common form of thyroid dysfunction in the intensive care unit.

Eligibility criteria:
inclusion criteria: * patients of both sexes admitted to the general icu of ain shams university hospitals with critical illness for more than 7 days \* diagnosis of icu acquired weakness will be made based on clinical criteria for icuaw and confirmed by nerve conduction studies. exclusion criteria: * patients with cerebrovascular accidents, neuromuscular disorders, spine abnormalities, spinal cord or head injuries, cns tumors, secondary thyroid disorders and electrolyte disturbances were excluded from the study. patients receiving thyroid replacement or anti-thyroid drugs for the treatment of any throid disorder will be also excluded from the study as these drugs may alter their thyroid biochemistry
clinical decision support for prep

Conditions: HIV Infections; Preexposure Prophylaxis (PrEP)

Summary: scale-up of hiv preexposure prophylaxis (prep) is a key strategy of the federal initiative to end the hiv epidemic. however, healthcare providers lack tools to identify patients who are at increased risk for hiv infection and thus likely to benefit from prep. this pilot study will test the hypothesis that an electronic health record (ehr)-based clinical decision support system that incorporates an hiv risk prediction model can help providers identify patients at increased risk for hiv infection and improve prep prescribing in safety-net community health centers. the clinical decision support system will be implemented in the ehr at 2-3intervention clinics, while 2 control clinics will receive standard of care. the primary outcome is prep prescriptions. other key metrics of prep-related care to be assessed include medication persistence, adherence to monitoring guidelines for prep, and rates of hiv/sti testing and diagnoses. the expected outcome is the foundation for a large-scale cluster randomized trial to test whether ehr-based clinical decision support tools for prep can improve prep prescribing and prevent new hiv infections in a national network of community health centers.


Eligibility criteria:
inclusion criteria: * primary care providers at participating clinics who are licensed to prescribe prep exclusion criteria: * n/a

Keywords: hiv preexposure prophylaxis (prep) risk prediction clinical decision support electronic health records
the butler-program 2.0: an internet platform for elderly

Conditions: Quality of Life

Summary: in this study, effectiveness of an internet based intervention (butler 2.0) for elderly is tested. participants (n= 60) will be randomly assigned to two different groups (intervention vs. waitlist). outcomes in terms of loneliness and quality of life will be assessed at pre-, post (6 weeks) and follow-up (3 months).

elderly people (age 65+ ) in zurich will have access to the butler program 2.0. butler 2.0 has been designed for elderly with little experience in the use of computers. several means of communication such as e-mail, video conferencing, chat and a blog are united on this platform. furthermore, relaxation exercises are offered in the form of virtual walks.

Eligibility criteria:
inclusion criteria: * age: 65 years or older * comprehension of german language * access to internet exclusion criteria: * suicidality * poor eyesight which makes use of intervention impossible
leucopatch™ study a multicenter study on the effect of leucopatch™ in diabetic foot ulcers

Conditions: Diabetic Foot Ulcers

Summary: the leucopatch™ study goal is to investigate whether the fully autologous growth factor-containing dressing leucopatch™ has a positive effect on healing rates of diabetic foot ulcers. the study seeks to gather data for comparison with previous data from similar wounds (historical controls). by subgrouping of the treated wounds (similar to the historical controls used) an assessment of which of the patient and wound-related factors that might indicate a beneficial effect of leucopatch™ is sought.

summary: treatment study the goal of the leucopatch ™ study is to investigate the effect of leucopatch ™ in diabetic foot ulcer. leucopatch ™ is a biologically active dressings which are made solely by the patient's own blood (autologous). it is produced in the ce (european conformity) marked leucopatch™ device and contains no additives. in this treatment study up to 75 typical diabetic patients with foot ulcers are included. these wounds are typically chronic and lead to reduced quality of life and ability to work, and extensive treatment costs. furthermore, these wounds often lead to amputations.the study is a multicenter study in which up to 10 wound clinics are expected to be involved. the primary endpoint is time to complete healing, the secondary endpoint is change in wound size.

Eligibility criteria:
inclusion criteria: * age \> 18 years * type i or type ii diabetes * age of wounds \> 6 weeks * wound area \<10 cm2 * wounds: texas degree ≤ type iia * perfusion status: toe pressure\> 30 mmhg, or transcutaneous oxygen measurement (tcpo2)\> 30 mmhg on the foot (measured within the last 3 months) or palpable foot pulse (equivalent to\> 60 mmhg) * diabetes control: hba1c \<12% * adequate off-loading (walker, therapy sandals etc.) * the patient can adhere to the treatment protocol and is expected to conclude the study * written informed consent exclusion criteria: * non-danish or swedish speaking * dementia * pregnant or nursing women * the patient cannot tolerate blood donation * hemoglobin : \< 6,5 mmol/l or 105 g/l * haemophilia, sickle cell anemia, severe thrombocytopenia, and leukemia or blood dyscrasias. * patient on dialysis * clinical signs of infection - including osteomyelitis (probe to bone). * necrosis of the wound * 40% change (+/-) in ulcer area in a 2-week run-in period with optimal therapy. * blood vessel reconstruction within the last 4 weeks. * participation in other clinical wound healing studies in the last 30 days. * failure to comply with study protocol in the 2-week run-in period.
regulated negative pressure-assisted wound therapy device

Conditions: Negative-Pressure Wound Therapy

Summary: regulated negative pressure-assisted wound therapy (rnpt) is regarded as a gold standard technology for treatment of various chronic and acute wounds. the investigators plan to evaluate the efficacy and ease of use of this device.


Eligibility criteria:
inclusion criteria: * chronic or acute wounds exclusion criteria: * uncontrolled bleeding * neoplasms in wound * exposed blood vessels * exposed internal organs
carfilzomib for the prevention of graft versus host disease

Conditions: Graft-versus-host Disease

Summary: the aim of this study is to evaluate the safety and efficacy of carfilzumib, which is a novel biological agent used in the treatment of multiple myeloma in preventing graft-versus-host disease, after stem cells transplantation from unrelated donors.


Eligibility criteria:
inclusion criteria: 1. patients with mds/aml 2. 18 years or older and willing and able to comply with the protocol requirements. 3. lvef ≥ 40%. 2-d transthoracic echocardiogram (echo) is the preferred method of evaluation. multigated acquisition scan (muga) is acceptable if echo is not available. 4. patients undergoing 8-10/10 hla matched unrelated and unmanipulated pbsc transplantation 5. patients conditioned with reduced intensity or reduced toxicity conditioning i.e. fludarabine combine with treosulfan or 2-4 days of i.v busulfan. 6. patients must sign written informed consent. 7. adequate birth control in fertile patients. exclusion criteria: 1. patients undergoing other type of transplantation or with other type of basic disease other than aml or mds. 2. patients with respiratory failure (dlco \< 30%). 3. active congestive heart failure (new york heart association \[nyha\] class iii to iv), symptomatic ischemia, or conduction abnormalities uncontrolled by conventional intervention. 4. patients with \> grade ii liver renal toxicity. 5. psychiatric conditions/disease that impair the ability to give informed consent or to adequately co-operate 6. bilirubin \> 3.0 mg/dl, transaminases \> 3 times upper normal limit 7. creatinine \> 2.0 mg/dl 8. ecog-performance status \> 2 9. uncontrolled infection 10. pregnancy or lactation 11. cns disease involvement 12. pleural effusion or ascites \> 1 liter.

Keywords: graft-versus-host disease stem cell transplantation matched unrelated donors proteosmoe inhibitor carfilzumib
comparative study in oral, breast approach and open thyroidectomy

Conditions: Thyroid Neoplasms

Summary: purpose: total endoscopic thyroidectomy including oral approach and breast approach has excellent cosmetic and several functional results. many patients, especially women, undergoing thyroid surgery are concerned about the postoperative cosmetic appearance of the neck. the procedure of total endoscopic thyroidectomy by breast approach only left three incisions, while by oral approach did not leave any incisions in the body surface, which is scarless in the neck, involved with a higher cosmetic result. however, the long-term property evaluation of total endoscopic thyroidectomy was not confirmed. the purpose of our study was to evaluate the surgical results of total endoscopic thyroidectomy (transoral approach and breast approach) versus conventional open thyroidectomy.

purpose: total endoscopic thyroidectomy including oral approach and breast approach has excellent cosmetic and several functional results. many patients, especially women, undergoing thyroid surgery are concerned about the postoperative cosmetic appearance of the neck. transoral endoscopic thyroidectomy via vestibular approach (toetva) and endoscopic thyroidectomy via breast approach were routinely performed in our institute. the procedures of total endoscopic thyroidectomy by breast approach only left three incisions, while by oral approach did not leave any incisions in the body surface, which is scarless in the neck, involved with a higher cosmetic result. however, the comprehensive comparison between transoral approach, breast approach and conventional open method was not confirmed. the purpose of our study was to evaluate the surgical results of total endoscopic thyroidectomy (transoral approach and breast approach) versus conventional open thyroidectomy.

Eligibility criteria:
inclusion criteria: 1. age: 15\~55 years old; 2. type: differentiated thyroid carcinoma, diameter ≤ 2cm, cn0 or cn1a, m0; 3. thyroid lobe was less than the second degree enlargement; 4. thyroid benign goiter, and the diameter ≤ 6cm exclusion criteria: 1. combine the surgical history of mandibular, oral, facial, or neck; 2. it was shown by preoperative radiological examination that the thyroid cancer has local invasion, n1b, or distant metastasis. 3. thyroid lobe was more than the third degree enlargement 4. any medical history that probably interfere the test results or increase the disease risks 5. the patient's compliance is not very well, and cannot work as the doctors asked