Kornimate/medical-research-clean huggingface dataset:
a study of long-acting injectable risperidone in the treatment of patients with schizophrenia or schizoaffective disorder

Conditions: Schizophrenia

Summary: the purpose of this study is to document the long-term safety and tolerability of risperidone, formulated as a long-acting injectable, in the treatment of patients with schizophrenia or schizoaffective disorder; in addition, to evaluate the long-term effectiveness of long-acting risperidone and its effect on quality of life

although many schizophrenia patients currently take oral antipsychotic medications, it is estimated that up to 75% of them have difficulty adhering to the daily oral regimen. long-acting injectable formulations may eliminate the need for daily medication and enhance patient compliance with the treatment regimen. this safety study is an extension of a randomized, double-blind, multicenter, parallel group study that investigates effectiveness and safety of risperidone injected intramuscularly in patients with schizophrenia or schizoaffective disorder. the present open-label study evaluates 3 different doses of a formulation of risperidone injected into the muscle at 2 week intervals for at least 1 year in patients with these conditions. assessments of effectiveness include the clinical global impression (cgi) overall severity of illness scale. quality of life will be assessed by the sf-36 health survey. safety evaluations include incidence of adverse events, physical examinations, and evaluations of the injection site, clinical laboratory tests, electrocardiograms (ecgs), and extrapyramidal symptom rating scale (esrs), a scale assessing muscle tone, gain, and abnormal movements. injections every 2 weeks for at least 1 year, beginning at 25milligrams\[mg\] and increasing to 50mg or 75mg (maximum dose). dosages may be increased or decreased at investigator's discretion. during the first 3 weeks, risperidone tablets (2mg) once daily to supplement injectable risperidone.

Eligibility criteria:
inclusion criteria: * patients must have completed the double-blind study (ris-usa-121) or withdrawn from that study for safety reasons or due to worsening of condition as determined by results from the cgi * diagnosis of schizophrenia or schizoaffective disorder according to criteria of diagnostic and statistical manual of mental disorders, 4th edition (dms iv) * otherwise healthy on the basis of physical examination, medical history, electrocardiogram, blood biochemistry and hematology tests, and urinalysis. exclusion criteria: * known intolerance, sensitivity, serious adverse events, or unresponsiveness to risperidone * diagnosis of dms iv axis i condition other than schizophrenia or schizoaffective disorder * diagnosis of substance abuse or dependence * use of psychostimulants or an antipsychotic medication other than risperidone * known disease of the central nervous system (stroke, parkinson's disease, huntington's disease, alzheimer's disease, cancer) * pregnant or nursing females, or those lacking adequate contraception.

Keywords: schizophrenia intramuscular injection psychotropic agents long-acting risperidone
the development of tolerance to α1-adrenoceptor blockade with chronic carvedilol treatment

Conditions: Heart Failure

Summary: there is now strong evidence from clinical trials that carvedilol therapy in heart failure is superior to therapy with metoprolol. not only does carvedilol have superior effects on lipid profiles, insulin sensitivity, renal blood flow, and reversal of pathologic remodeling but also its use is associated with fewer deaths compared to metoprolol. these facts make it important to carefully define how metoprolol and carvedilol are pharmacologically different. one potential difference is α1-ar antagonism. if we demonstrate that these α1-ar effects are preserved with chronic therapy, then α1-ar blockade may have an important role in carvedilol favorably altering the natural history of heart failure. on the other hand, if we demonstrate that tolerance to the α1-ar blockade effect of carvedilol decreases with time, then it would be unlikely that this pharmacologic property contributes to the efficacy of carvedilol. in such a case other pharmacologic properties, such as antioxidant activity, would appear to be important. these results will help guide future studies into chf and ar blockade.


Eligibility criteria:
inclusion criteria: 1. age of 18 to 85 years 2. symptomatic heart failure, nyha class i to iii 3. left ventricular ejection fraction \< 0.40 4. give written informed consent exclusion criteria: 1. active myocarditis 2. congenital heart disease 3. uncorrected, hemodynamically significant stenotic valvular disease 4. hypertrophic cardiomyopathy 5. asthma or other obstructive airway diseases requiring bronchodilators 6. heart rate \ 90 mm hg 7. uncontrolled hypertension (systolic bp \>140 mmhg, diastolic bp \> 90 mmhg). 8. sick sinus syndrome, mobitz type 2 second degree av block or third degree av block unless controlled with an artificial implantable pacemaker 9. nyha functional class iv symptoms 10. treatment with an excluded medication (see excluded medications below) 11. myocardial infarction or coronary artery intervention (cabg or angioplasty) within three months 12. unstable angina pectoris 13. presence of any progressive systemic disease that would be expected to impact the patient's outcome over the time course of the study 14. uncorrected endocrine disorders including primary aldosteronism, pheochromocytoma, hyperthyroidism, hypothyroidism, brittle type 1 diabetes mellitus 15. evidence of significant renal disease (serum creatinine \> 2.5 mg/dl), or hepatic disease (transaminase level \> three fold higher than laboratory normal) 16. symptomatic peripheral vascular disease 17. inability or unwillingness to cooperate with study or give written informed consent
role of multi-detector computed tomography in differentiation between different types of ascites

Conditions: Ascites

Summary: role of multi-detector computed tomography in differentiation between different types of ascites

1. to detect accuracy of mdct in differentiation between different types of ascites and its underlying cause . 2. to evaluate the diagnostic accuracy of measuring the ct density of the ascitic fluid (in housefield units) to differentiate between different types of ascites in comparison to aspiration cytology results.

Eligibility criteria:
inclusion criteria: * all patients who are diagnosed with ascites by clinical examination or by any other investigations such as ultrasound. exclusion criteria: * patient with bleeding tendancy and on anticoagulant drugs.- * patients who are pregnant .
effects of holy-comod and tears naturale forte in patients after phaco+iol

Conditions: Age-related Cataract

Summary: the purpose of the study it to compare the effects of holy-comod and tears naturale forte on ocular surface and tear inflammatory mediators in patients after phaco+iol.


Eligibility criteria:
inclusion criteria: * 60-72 years old * classification of lens nucleus is locs ⅱ exclusion criteria: * patients with previous history of ocular surgery, corneal diseases,uveitis ,ocular hypertension or glaucoma ,systemic diseases.

Keywords: age-related cataract holy-comod tears naturale forte phacoemulsification inflammatory mediators
comparison of the effects of physical therapy with and without magnetic field therapy in people with low back pain

Conditions: Low Back Pain

Summary: a randomized and controlled trial to people with low back pain who are divided into 2 groups of treatment: 1- people treated with a protocol of physical therapy techniques without magnetic field therapy; 2- people treated with the same protocol of physical therapy techniques adding a magnetic stimulation treatment. the interventions are conducted in 3 sessions provided during 3 weeks.the lumbar pain and disability are assessed before and after the intervention, and lumbar flexion and extension pain are assessed before and after each session in all the participants.

this study is a randomized controlled trial evaluating clinical effects of a protocol of physical therapy treatment (ptt), via manual therapy and active mobilization, adding or not a magnetic field therapy in people with non-specific low back pain lasting at least 6 weeks. participants were randomized to receive either a ptt protocol including a magnetic stimulation treatment or the same ptt protocol with a sham magnetic intervention. the interventions are conducted in 3 sessions provided during 3 weeks. intervention: a description of the 2 groups of treatment: 1. - experimental group 1: a protocol of physical therapy treatment including: * manual therapy techniques for inhibition of piriformis, quadratus lumbar, and paravertebral muscles in prone position and bilaterally. * 2 functional techniques applied to the sacrum in prone position. * a myofascial release of ligaments inserted to the sacrum in prone position and bilaterally. * manual therapy technique for inhibition of psoas-iliacus muscle in supine position and bilaterally. * stretching techniques of piriformis, gluteal and paravertebral muscles in supine position and bilaterally. * active gluteus maximus contraction in supine position bilaterally. to this protocol, a 15 minutes of magnetic field therapy treatment applied to the lumbosacral region in prone position is added. 2. - experimental group 2: the same physical therapy treatment protocol with a sham magnetic intervention applying in the same region with a disconnected device during 15 minutes.

Eligibility criteria:
inclusion criteria: * the inclusion criteria were individuals aged between 18 and 65 years with a diagnosis of non-specific low back pain, with or without lower limb irradiation, lasting at least 6 weeks. exclusion criteria: * pregnancy, spinal tumor or infection, diabetes, spinal fracture or previous spine surgery. * patients with a history of rehabilitation treatment for back pain within the preceding month * unstable medical disorder not controlled by standard treatment and those with a cardiac pacemaker or using any other electrical devices or prosthesis.

Keywords: low back pain physical therapy rehabilitation magnetic field therapy
a test of iron malabsorption in patients with iron deficiency anemia

Conditions: Iron Deficiency Anemia

Summary: the objective of the study is to develop a simple, noninvasive test for evaluation of iron absorption as a tool to determine the cause of iron deficiency anemia. healthy, premenopausal women with iron deficiency with or without anemia will be recruited for the study. participants will, over the course of two months, ingest an iron solution three times; after each iron ingestion, participants will collect their stool and bring it to the study investigators for assessment of iron content.


Eligibility criteria:
inclusion criteria: * ferritin \<40 exclusion criteria: * pregnant, * post-partum, * s/p git surgery, * known malabsorption, * coeliac disease, * helicobacter pylori

Keywords: anemia iron deficiency anemia iron deficiency absorption iron absorption iron uptake
perfusion and collaterals imaging with c-arm ct

Conditions: Ischemic Stroke

Summary: single-center, single-arm pilot study to evaluate the ability of c-arm computed tomography imaging to assess perfusion parameters, collateral vessels, recanalization and brain ischemia in patients with suspected or proven ischemic stroke or brain ischemia in the neuro-angiography suite.

in neurovascular disease, and stroke in particular, physicians often want to be able to detect regions of ischemia in the brain and the recanalization status of cerebral blood vessels. perfusion and collateral vessel imaging is a possible approach for doing this. these imaging techniques are able to differentiate ischemic core in parenchymal tissue in the brain versus salvageable penumbra tissue around the core. also the recanalization status of blood vessels can be evaluated using this technique. this study wishes to investigate if the x-ray c-arm in the treatment room can generate perfusion and collateral images of clinical value during treatment, using a technique known as c-arm computed tomography. if this study shows that to be the case, then it might be feasible in the future to bypass ct or mr perfusion/collateral imaging for some patients when they arrive at the hospital, since all this imaging can be done in the treatment room. in the future, this imaging approach may have the potential to simplify and improve patient workflows and reduce the time between hospital arrival and treatment for these patients and could also potentially compensate for missing imaging information.

Eligibility criteria:
inclusion criteria: 1. subject has suspected or proven ischemic stroke or brain ischemia. 2. subject requires diagnostic and/or interventional imaging in the neuro-angiography suite. 3. subject or subject's legally authorized representative has signed an institutionally approved research informed consent form. 4. subject ≥ 18 years old. exclusion criteria: 1. subject or subject's legally authorized representative is unable or unwilling to consent to the study. 2. subject with documented contrast medium injection contraindication due to severe kidney disease or allergy.
liver transplantation with two-stage liver resection in unresectable liver cancer , metastases or emd-stage liver disease (ltlr-lc)

Conditions: Liver Transplant Disorder; Hepatic Cancer; End-stage Liver Disease

Summary: colon cancer and primary liver cancer are common malignant tumors with low survival rate worldwide, and unresectable primary liver cancer and colon cancer liver metastases have worse prognosis. end-stage liver disease is equated with advanced liver disease, liver failure and decompensated cirrhosis because they are generally irreversible. liver transplantation is a treatment option for the above-mentioned patients and is expected to improve the prognosis of the patients, but the biggest problem faced by such patients is the shortage of donor livers. recently, a new surgical modality, resection and partial liver segment 2-3 transplantation with delayed total hepatectomy (rapid), can greatly alleviate these problems.based on clinical surgical experience, our center proposes and designs a clinical study of adjuvant liver transplantation combined with two-stage hepatectomy in the treatment of patients with unresectable primary liver cancer, colorectal cancer liver metastases, or end-stage liver disease. by improvement of rapid operation, the safety and efficacy of this treatment method in patients with those disease were evaluated.


Eligibility criteria:
inclusion criteria: 1. aged 18-75 years; 2. patients with unresectable primary hepatocellular carcinoma or colorectal cancer with liver metastases who also meet the following criteria: tumor shrinkage (still unresectable) or no significant progression after a first-line chemotherapy regimen of 6-8 weeks; no other abdominal metastases or 1-3 resectable pulmonary metastases; 3. patients with end-stage liver disease; 4. preoperative child classification of a or b, able to tolerate the subsequent surgical program 5. signed informed consent note: one of the second or third criteria needs to be fulfilled and all the rest of the selection criteria need to be fulfilled exclusion criteria: 1. extrahepatic tumor burden (except for resectable lung metastases) and/or macrovascular tumor infiltration 2. tumor progression during chemotherapy or important comorbidities that affect surgery 3. uncorrectable cardiopulmonary disease with high surgical risk 4. anatomical abnormalities that preclude liver transplantation 5. persistent non-compliance with medical care 6. combined with other diseases such as aids that affect surgery or tumor progression

Keywords: liver transplantation hepatectomy
prevalence of non-carious cervical lesions in patient with gingival recession and associated risk factors

Conditions: Non-carious Cervical Lesion

Summary: the study aims at determining the prevalence of non carious cervical lesions in patients with gingival recession in egyptian population and associated risk factors including gingival biotype, keratinized tissue width, gingival index, plaque index, occlusal wear grade, sensitivity. and a questionnaire will be filled by patients with another risk factors including age, gender, toothbrush frequency and type, bruxism, gastric reflux, soft drinks, alcohol and citrus fruits. also ohip-14 will be answered in a questionnaire form by patients.

dental patients will be recruited in a consecutive manner from diagnostic centre at cairo university dentistry faculty. patients with nccl will be selected for questionnaires and clinical examination. thorough oral examination will be done, the full aim of the study will be explained to the patient, and patient acceptance is a must. the questionnaire will be done with face to face interview with the patient will include associated risk factors including gingival biotype, keratinized tissue width, gingival index, plaque index, occlusal wear grade, sensitivity. and a questionnaire will be filled by patients with another risk factors including age, gender, toothbrush frequency and type, bruxism, gastric reflux, soft drinks, alcohol and citrus fruits. also ohip-14 will be answered in a questionnaire form by patients including: functional limitations, physical pain, psychological discomfort, physical disability, psychological disability, social disability, handicap. then clinical examination will be done for nccl using mirror, probe, light of the unit, air tip.

Eligibility criteria:
inclusion criteria: * adult patients with nccl and gingival recession whose age is above 15 years old * patients consulting in dental diagnostic centre, faculty of dentistry, cairo university * patients provide informed consent exclusion criteria: * patients having problem in mouth opening or undergoing intermaxillary fixation where oral examination is not possible * patients diagnosed with psychiatric problems
life quality of children in cancer remission during school reintegration

Conditions: Cancer Remission

Summary: few data about the evaluation of consequences of past life with cancer on life quality of children in school reintegration are available in literature. nevertheless, some of these studies show that the reintegration impairs life quality of these children (school difficulties, conflictual relations with peers...). the hypothesis is that children with past life with cancer have more chances to have school integration difficulties with a consequent life quality degradation compared to healthy children. the main objective of this project is to study the relation between the satisfaction of school reintegration of children in cancer remission and the evolution of life quality in the medium term (after getting back to school). more exactly, it is the question if the satisfaction of school reintegration influences life goals and priorities of these children. the secondary objective is to study the role of psychological status of these children (anxiety, depressive symptoms) on satisfaction-life quality relation. a group of children with cancer history sent to ordinary school is compared to a control group of children sent to school in the same conditions (sex and age matched). data are collected with questionnaires some months to several years after school reintegration and same questionnaires 1 year later. if the study hypothesis is confirmed, this study will show the necessity of a long term follow up of children in cancer remission and not only medical care, but also psychological and social care, in order to support a better school reintegration.


Eligibility criteria:
group of children in cancer remission: inclusion criteria: * children of both sexes in cancer remission (leukemia, with or without transplant and solid tumors), aged 8 to 12 * stop of treatment since at least 6 months * back to school since some months to several years * signed consent of parents exclusion criteria: * psychic difficulties * specialized education group of control children: inclusion criteria: - signed consent of parents

Keywords: children life quality school reintegration
evaluation of a decision aid for early pregnancy loss

Conditions: Early Pregnancy Loss

Summary: this study aims to determine the effect of the healthwise decision aid on shared decision making in women undergoing management of early pregnancy loss.

early pregnancy loss (epl) or miscarriage is a common problem occurring in 15-20% of pregnancies. epl can safely be managed surgically, medically, or expectantly; patient preferences, together with provider recommendations, should be used to guide treatment decisions. the three management options differ substantially experientially for patients. previous literature has shown that patients have preferences for treatment and higher satisfaction when treated according to their preferences. decision aids provide individualized information to help patients clarify their priorities and personal values. there is good evidence that decision aids compared to usual care resulted in greater knowledge, more realistic expectations, lower decisional conflict relating to feeling informed, more active decision making, less people remaining undecided, and greater effect agreement on value and choice. despite this, there is limited research on the extent of decisional conflict experienced by women undergoing treatment for epl, or the effect of decision aids on decisional conflict. furthermore, only a few decision aid tools are publicly available for this indication. the healthwise decision aid tool receives high scores by the international patient decision aid standards scale, and is readily available to patients within the clinical site's electronic medical record. the investigators propose a pilot randomized control trial, enrolling 50 participants with epl. the study will measure baseline decisional conflict, and randomize participants to counseling with or without the decision aid. the investigators intend to study the decisional conflict scale at baseline and after counseling, knowledge scores, decision regret and the 9-item shared decision making questionnaire (sdm-q9) after counseling. study data can be used to inform future research and to identify patients with predictors for high decisional conflict. this study is the first step towards validation of a high-quality decision aid tool for patients undergoing epl management. it will also be the first study to report on decisional conflict and regret in patients with early pregnancy loss.

Eligibility criteria:
inclusion criteria: * english speaking * definitive diagnosis of early intrauterine pregnancy loss (including anembryonic pregnancy and missed abortion \[ultrasound examination demonstrates fetal pole without cardiac activity measuring between 5.3 and 7mm or an abnormal growth pattern diagnostic of epl\]) * 18 years or older * willing and able to give informed consent exclusion criteria: * pregnancy of unknown anatomic location * unable to read english * prior options counseling with a family planning provider * clinically unstable requiring emergent surgical management with uterine evacuation.