Kornimate/medical-research-clean huggingface dataset:
quality of life and mental health in children and adolescents

Conditions: Psychiatric Diagnosis; Mental Disorders

Summary: the purpose of this study is to investigate different aspects of quality of life and mental health in patients under treatment in a child and adolescent psychiatric outpatient clinic and in the normal population.

measuring and monitoring quality of life in children and youths continues to increase in importance to both researchers and decision makers. only a limited number of well validated instruments that measure quality of life in children exists, and in norway only few has been translated into norwegian. up to date there are no studies investigating the quality of life in norwegian child and adolescent psychiatric patients in a longitudinal perspective, compared to the normal population. two generic quality of life instruments (kindl, bullinger \& ravens-sieberer 2000 and the ilc, matejatt \& remschmidt 1998) are introduced in norway by this study in addition to the use of other well established measures like the "child behaviour check list" (achenbach et al. 2001), etc. comparisons: 400 patients and their parents in a child psychiatric outpatient clinic 2000 pupils from the normal population in the middle of norway repeated measures after 6 months in both groups. in addition a follow up study for the clinical group 3 years after referral started in june 2006.

Eligibility criteria:
inclusion criteria: * all children 9-16 years of age, attending the 4th, 6th, 8th or 10th grades at public or private schools with at least 50 pupils, in the period from the 1st of september 2004 until 15th of july 2005 in the county of sør-trøndelag. subjects and parents have to give their informed consent. * all patients 8-10 years of age consecutively referred to to the child psychiatric outpatient clinic in the period from the 1st of june 2003 until 31st of december 2005, having a minimum of two direct contacts with the clinical staff. patients and parents have to give their informed consent. * follow up: three years after the patients met at the outpatient clinic for the first time. exclusion criteria: * pupils lacking sufficient competence in the norwegian language, due to foreign background or having a mental developmental level of more than two grades under the respective grade. * patients with psychosis or serious mental retardation.

Keywords: quality of life mental health children adolescents normal population
clinical research of 18f-alfatide ⅱ pet/ct in breast cancer

Conditions: Breast Cancer

Summary: 18f-alfatide ⅱ pet/ct in breast cancer patients

the investigators aim to assess the clinical application of 18f-alfatide ⅱ pet/ct in the diagnosis and treatment response monitoring of breast cancer.

Eligibility criteria:
inclusion criteria: * the patients have been suspected or diagnosed with breast cancer and they have not received any treatment; it must fulfill the ethical requirements and subjects have signed an informed consent. exclusion criteria: * pregnancy or nursing mothers; those patients accompanied by other serious diseases such as cardiac functional insufficiency, hepatic and renal function insufficiency.

Keywords: pet/ct alfatide ⅱ breast cancer
a retrospective non-intervention study to characterize folate rescue treatment in osteosarcoma patients treated with hdmtx

Conditions: Osteosarcoma

Summary: the purpose of this study is to investigate to which extend osteosarcoma patients do not meet the criteria for successfully advancement to next planned chemotherapy course.

methotrexate is one of the most effective chemotherapy drugs in the treatment of osteosarcoma. however, it has severe side effects. the physicians tries to save or "rescue" normal cells from the side effects of methotrexate by giving folinic acid. folinic acid administration starts 24 hours after methotrexate and given regularly until methotrexate levels are low and not dangerous to normal cells anymore. despite this rescue, side effects are still a problem and many patients are not well enough to receive subsequent chemotherapy on time. this is a multi-center, observational retrospective study with osteosarcoma patients, 2 years of age or older, who have received at least one (1) course of hdmtx treatment with folate rescue in a map schedule between 01january 2009 and 31 may 2014, both dates included. patients must have initiated their hdmtx treatment after 01 january 2009, received at least one (1) course of hdmtx treatment with folate rescue, and received their last map intervention (regardless if the patients received all planned hdmtx treatments or terminated prematurely their treatment) by 31 may 2014. patient data collected for the study will be extracted from hospital medical records and will include information related to scheduled and/or received hdmtx courses. the collected data will include: laboratory values confirming suitability to receive next chemotherapy intervention at scheduled time, drug administration regimen (both hdmtx and supportive care), toxicity management (hydration and folate rescue regimens), and toxicity monitoring.

Eligibility criteria:
inclusion criteria: * patients must have histological evidence of osteosarcoma including metastatic osteosarcoma. * patients must have initiated their hdmtx treatment after 01 january 2009 and should have completed their map treatment by 31 may 2014. * patients should have received at least one (1) hdmtx course within map treatment. * patients must be at least 2 years of age. * patient, parent(s), or guardian(s), as appropriate, is/are willing to provide signed informed consent, if applicable according to national regulation. exclusion criteria: * no exclusion criteria
visual performance investigation of two toric soft contact lenses

Conditions: Refractive Error; Astigmatism; Myopia; Hyperopia

Summary: the purpose of this study is to compare the amount of coma as measured by aberrometry induced by two silicone hydrogel toric lenses in astigmatic participants.


Eligibility criteria:
inclusion criteria: * sign informed consent; * wears toric soft contact lenses; * can be successfully fit with study lenses within the power ranges available; * has cylinder of ≥ -0.75 diopter in both eyes; * has correctable vision of at least 0.1 (logmar) or better in each eye at distance with both study lenses; * willing and able to wear study lenses on a daily wear basis for at least 5 days a week, minimum 8 hours per day, and attend all study visits; * other protocol-defined inclusion criteria may apply. exclusion criteria: * any ocular condition that would contraindicate contact lens wear; * use of medications for which contact lens wear could be contraindicated; * monocular (only 1 eye with functional vision) or fit with 1 lens; * history of herpetic keratitis, ocular surgery, or irregular cornea; * known sensitivity to the diagnostic pharmaceuticals to be used in the study; * requires presbyopic correction; * use of rewetting/lubricating eye-drops more than twice a day; * other protocol-defined exclusion criteria may apply.

Keywords: myopia hyperopia astigmatism contact lenses
comparing breast magnetic resonance imaging (mri) and contrast-enhanced mammography (cem)

Conditions: Breast Cancer Female

Summary: the investigators will study the financial, time, and psychologic benefit of contrast enhanced mammography (cem) compared with magnetic resonance imaging (mri) for breast cancer evaluation and ultimately encourage practices and referring providers to use it more routinely in practice. specific research objectives are to: * determine financial costs of performing a cem to breast mri * compare time costs involved with cem to breast mri * compare psychologic costs involved with cem to breast mri.


Eligibility criteria:
inclusion criteria: * age \> or equal to 30 years * clinically eligible for cem or breast mri * newly diagnosed cancer exclusion criteria: * pregnant as verified by patient report. given that this test is being performed for clinical purposes, the determination of pregnancy status will be resolved via the standard clinical pathway.

Keywords: contrast enhanced mammography (cem) breast mri financial costs time costs state-trait anxiety inventory (stai)
nlr and emergency surgery

Conditions: Emergency Surgery

Summary: in the immune system, it has been observed that the preoperative neutrophil-to-lymphocyte ratio (nlr) is an index that reflects the state of inflammation and oxidative stress. in the perioperative period, nlr has been described as a predictor for patients who will develop renal injury, ischemic stroke, and myocardial injury. since preoperative inflammation is a predictor of morbidity and mortality in patients undergoing non-cardiac surgery, a retrospective analysis of the inflammatory status of patients undergoing surgery at the center is proposed.

a retrospective analysis of patients operated on at the clinical hospital of the university of chile is proposed. the search will be conducted in the electronic medical records of all patients operated on between january and december 2021, with no exclusion criteria for this analysis. demographic data, complications, length of hospital stay, and specific characteristics such as the need for mechanical ventilation, time spent in intermediate care units, and icu as well as total hospitalization time will be recorded. for the purpose of this study, the preoperative complete blood count of the patients will be analyzed to search for hematological variables that reflect the state of preoperative systemic inflammation.

Eligibility criteria:
inclusion criteria: * availability of complete blood count in electronic medical records of all patients operated on between january and december 2021 exclusion criteria: * none

Keywords: neutrophil-to-lymphocyte ratio emergency surgery nlr
characterization of slow coronary flow

Conditions: Cardiovascular Abnormalities; Vascular Diseases

Summary: description of the phenomena "slow coronary flow" (scf), according to the data that has been collected from patients hospitalized with specific criteria. clinical follow-up of these patients to determine whether they suffered from any cardial or psychological disorders that might be a result of scf.


Eligibility criteria:
inclusion criteria: * anginal pain * laboratory markers * pathological ecg for ischemia exclusion criteria: * obstructed coronary artery during catheterization * very narrow coronary artery

Keywords: slow coronary flow
unaffected hand in hemiplegia

Conditions: Hemiplegia; Upper Extremity Problem

Summary: the primary aim of our study is to evaluate the functional status of the unaffected hand in hemiplegic patients. the secondary aims are to compare the functional states of the unaffected hand between right and left hemiplegias, and to evaluate the relationships between the functional status of the unaffected hand and the healing phase of the hemiplegic side and activities of daily living. this cross-sectional study included 30 right hemiplegic and 30 left hemiplegic patients with a history of ischemic cerebrovascular accident (cva) in the last 1 year and 30 healthy volunteers as a control group. participants' data on age, gender, height, weight, comorbidities, time after stroke, and affected body half were recorded. in the patient group, the stages for the upper extremity and hand were evaluated according to the brunnstrom recovery stages. afterwards, the participants' hand grip strengths were evaluated with a jamar type hand dynamometer, pinch strengths with a pinchmeter, and hand dexerity with the nine hole peg test (nhpt). evaluations were made in the unaffected hand in the patient groups and in both hands in the control group. the lawton instrumental activities of daily living scale (lawton-iadl) and the functional independence measure (fim) were applied to the patient groups.


Eligibility criteria:
inclusion criteria: this cross-sectional study included 30 right hemiplegic and 30 left hemiplegic patients with a history of ischemic cerebrovascular accident (cva) in the last 1 year and 30 healthy volunteers as a control group. all patients and healthy volunteers were right hand dominant. exclusion criteria: patients with a history of cva in the last 1 month, bilateral hemispheric ischemic lesion, moderate/severe cognitive impairment, aphasia, neglect, and patients/healthy volunteers with severe systemic, inflammatory, degenerative and neurological diseases that may lead to loss of hand functions, a history of surgery or trauma in the upper extremity in the last 3 months, and younger than 18 years of age were excluded.
effects of nucleus basalis of meynert stimulation on cognitive disorders in dementia with lewy bodies

Conditions: Dementia With Lewy Bodies

Summary: deep brain stimulation has been developed as a substitute for the classical lesioning methods previously used in stereotactic and functional neurosurgery. recent, anecdotal cases reports suggested that electrical stimulation of the cholinergic output of the nucleus basalis of meynert (nbm) may improve cognitive performances, especially the memory tasks. the present study aims to assess the effect of bilateral electrical stimulation of the nbm on the mnesic performance \[assessed by the sum of the three free recalls of the free and cued selective recall reminding test (fcsrt)\] in patients diagnosed with probable, moderate, dementia with lewy bodies.


Eligibility criteria:
inclusion criteria: * diagnosis of probable lewy-body dementia according to the internationally accepted consensus criteria (mckeith, 2005) * outpatients, male or female, aged between 18 to 75 years * moderate dementia defined by a mini-mental state examination (mmse) score between 16 and 26 * stable dose of cholinesterase inhibitors (maximal dose tolerated) for a minimum of 1 months * patients receiving antiparkinsonian treatment unmodified for 3 months, if treated * french as native language * written informed consent of the patient * written informed consent of the caregiver exclusion criteria: * other causes of dementia (alzheimer dementia, vascular dementia, dementia associated with parkinson's disease) * other causes of extrapyramidal symptoms (parkinson's disease) * patients with a history of severe psychiatric disorders, such as psychosis. earlier episodes of depression and/or anxiety without hospitalization are not exclusion criteria * contraindications for mr imaging (claustrophobia, metallic foreign bodies, pacemakers, etc) * mri evidence of cerebral microbleeds * surgical contraindications: especially, hemostatic disorders, severe cortical atrophy * patients receiving treatments that may interfere with the cholinergic system: anticholinergics, cholinomimetics. * patients receiving neuroleptics * patients with a history of alcohol or drug abuse * pre-existing structural brain abnormalities (such as tumor, infarction, or intracranial hematoma) * previous neurosurgical intervention * patients with a progressively fatal disease, or life expectancy £ one year * asthma * severe visual deficit of ophthalmic origin (such as glaucoma, age related macular degeneration, cataract) * fertile women not using adequate contraceptive methods * women who are pregnant or breast feeding

Keywords: dementia with lewy bodies nucleus basalis of meynert deep brain stimulation
a study to investigate the safety, tolerability, and pharmacodynamics of jnj-54175446 in participants with major depressive disorder

Conditions: Depressive Disorder, Major

Summary: the primary purpose of this study is to investigate the safety and tolerability of jnj 54175446 in participants with major depressive disorder (mdd).


Eligibility criteria:
inclusion criteria: * body mass index (bmi) must be between 18 and 32 kilogram per square meter (kg/m\^2) inclusive * related to symptoms of depression: participant must meet the diagnostic and statistical manual of mental disorders (dsm)-iv or v diagnostic criteria for major depressive disorder \[mdd\] (international classification of diseases (icd)-code f32.x and f33.x), without psychotic features, as confirmed by the mini 6.0; participant must have an ids-c30 total score greater than or equal to (\>=) 30 using the semi-structured interview guide for the ids-c30 * participant is, during this episode of depression, treatment naïve or treated with at most one selective serotonin reuptake inhibitor (ssri) over a minimum of 6 weeks and a maximum of 6 months, and subject is being treated at an adequate dose, showing a partial response at enrolment * a woman of childbearing potential must have a negative serum pregnancy test at screening and a negative urine pregnancy test upon admission * a woman must agree not to donate eggs (ova, oocytes) for the purposes of assisted reproduction during the study and for at least 3 months after receiving the last dose of study drug exclusion criteria: * has a primary dsm-iv or v diagnosis of general anxiety disorder (gad), panic disorder, obsessive compulsive disorder, posttraumatic stress disorder, anorexia nervosa, or bulimia nervosa. participants with comorbid gad, social anxiety disorder, or panic disorder for whom mdd is considered the primary diagnosis are not excluded * has a length of current major depressive episode greater than (\>) 24 months despite adequate treatment * has failed more than 2 treatments with a different pharmacological mode of action despite an adequate dose and duration during a previous, or the current depressive episode * participant has a history of substance use disorder according to dsm-v criteria, except nicotine or caffeine, within 6 months before screening. however, participants who have completed a treatment for (alcohol) addiction more than 8 weeks prior to first dose administration and are under continuous control of the study center, may be included if the risk to fall back is considered minimal and no significant abnormalities are shown in clinical laboratory or other predose safety assessments * obstructive sleep apnea/hypopnea (apnea/hypopnea index \>10) or restless legs syndrome (periodic leg movements with arousal index \>15) as assessed on the first or second polysomnography (psg) recording during screening
precision analytic research methods in ocd

Conditions: Obsessive Compulsive Disorder

Summary: psychiatric disorders characterized by compulsivity, such as obsessive-compulsive disorder (ocd), result in considerable functional impairment and many individuals do not respond to gold-standard treatments. compulsivity has long been thought to occur due to exaggerated habits and reduced goal-directed control, although more recently, this conceptualization of compulsivity as an imbalance of two cognitive systems has been challenged as overly narrow. this study will recruit 100 individuals (50 adults diagnosed with ocd, 50 healthy controls) and leverage the measurement precision offered by theory-driven computational modeling in combination with electroencephalogram (eeg) to go beyond this binary theory of compulsivity, revealing how more complex interactions of neurocognitive subcomponents contribute to compulsivity-information that could ultimately lead to improved treatment personalization and clinical outcomes.


Eligibility criteria:
inclusion criteria: participants must be: * between the ages 18-55 years old * english-speaking * right-handed * able to provide consent exclusion criteria: individuals diagnosed with ocd will be excluded if: * they meet diagnostic criteria for certain other psychiatric disorders * are taking psychiatric medication or have received behavioral treatment for ocd within a certain timeframe * if it is unsafe for them to participate in research healthy control participants will be excluded if: * they have a current psychiatric disorder * a lifetime history of certain psychiatric disorders * are taking psychiatric medication or have in the past * have a parent or sibling who has been diagnosed with ocd * if it is unsafe for them to participate in research

Keywords: obsessive compulsive disorder exposure and response prevention cognitive behavioral therapy electroencephalogram
efficacy testing of djulis-buckwheat drink on cardiovascular protection

Conditions: Prehypertension; Hypertension Stage 1

Summary: the purpose of the trial is to evaluate the effect of djulis-buckwheat drink on cardiovascular protection after ingesting for 8 weeks. in addition, the correlation between the supplement and the cardiovascular disease-related gene expression is evaluated. the results will be used for the application of functional products for cardiovascular protection. ninety subjects (age 30\~65) with prehypertension or hypertension stage 1 will be included and randomly allocated into 3 groups: placebo, djulis-buckwheat and buckwheat. the subjects will take sample (100 ml/day) for 8 weeks. blood pressure will be measured on week 0, 1, 2, 4, 6 and 8. the blood biochemical parameters and gene expression analysis will be examined on week 2, 4, 6, 8 and 10 (the follow up).


Eligibility criteria:
inclusion criteria: * systolic blood pressure 121-159 mmhg or diastolic blood pressure 81-99 mmhg * age: 30-65 exclusion criteria: * have diagnosed and documented critical illness(nhi specification) * had emergency record or admission note in the past three months * not be pregnant or breast-feeding a child
novel non-invasive monitoring parameter in a hospital setting

Conditions: Respiratory Insufficiency; Respiratory Failure

Summary: data collected from this study will be used to evaluate the performance of a monitoring algorithm.

the goal of this study is to assess equivalency, performance, and accuracy of a new monitoring algorithm in a hospital setting.

Eligibility criteria:
inclusion criteria: 1. subjects 18 years old or older 2. written informed consent from the patient or their legally authorized representative before initiation of any study-related procedures 3. subjects on general care floor exclusion criteria: 1. severe contact allergies to standard adhesive materials 2. abnormalities that may prevent proper application of the device 3. women who are pregnant or lactating 4. subjects with significant arrhythmia

Keywords: hospital setting
glucocorticoid-induced tumour necrosis factor receptor related protein (gitr) in rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: this study aimed to measure serum and synovial fluid (sf) levels of gitr in patients with recent onset ra before and after initiation of therapy

1. technical design: study design: a longitudinal observational cohort study. this study will be carried out on two groups: * group (i): fifty early onset rheumatoid arthritis (ra) patients fulfilled the 2010 american college of rheumatology (acr) - european league against rheumatism (eular) classification criteria for ra \[11\]. * group (ii): twenty healthy individuals of matching age and sex as control group. both groups will be recruited from the in-patients and out-patients' clinic of the rheumatology, rehabilitation\& physical medicine department, benha university hospital. all patients will be evaluated at baseline at 6 months follow up using: (a) clinical evaluation 1. complete history taking. 2. thorough clinical examination. 3. disease activity using das28 \[12\] (b) laboratory assessment: all patients will be subjected to the following measurements: 1. erythrocyte sedimentation rate (esr). 2. c reactive protein (crp). 3. rheumatoid factor (rf) 4. anti-cyclic citrullinated peptide (anti- ccp). 5. glucocorticoid-induced tumour necrosis factor receptor related protein (gitr) (d) musculoskeletal ultrasound assessment: ultrasound examinations will be performed for patients and control groups using a logiq e equipped with a broadband 8- to 13-mhz linear transducer 2. statistical analysis the collected data will be tabulated and analyzed using suitable statistical computer version.

Eligibility criteria:
inclusion criteria: * fulfill 2010 criteria for classification of rheumatoid arthritis recentely diagnosed exclusion criteria: * infection malignancy receiving treatment

Keywords: rheumatoid arthritis glucocorticoid-induced tumour necrosis factor receptor related protein