Kornimate/medical-research-clean huggingface dataset:
evaluation of hexyresorcinol vs hydroquinone for photoaging

Conditions: Photoaging

Summary: photoaging is a common concern within the cosmeceutical industry with many products that are available. one frequently used product is hydroquinone that is used to even skin tone. however, hydroquinone has several shortcomings. the ingredient is controversial for its potential safety issues and it has been banned in europe. an alternative ingredient that has emerged for its potential use is hexyresorcinol for evening skin tone. additionally, hexylresorcinol may have other photoaging benefits such as the reduction in the appearance of fine lines. therefore, the aim of this study is to assess how hexyresorcinol may compare to the use of hydroquinone in the setting of photoaging.


Eligibility criteria:
inclusion criteria: * females aged 35-65 (limiting to females so that there is not heterogeneity with the influence of hormones. also, females are a much larger user base of skin care products) * individuals who have not participated in any other clinical studies using the same test sites (face) and hand in the past 14 days * individuals with fitzpatrick skin type i-iv * no known medical conditions that, in the investigator's opinion, may interfere with study participation. exclusion criteria: * • individuals who have been on any medication that has caused a change in skin pigmentation based on the opinion of the investigator * individuals who have history of acute or chronic disease that would likely interfere with or increase the risk on study participation at the discretion of the investigator * female volunteers who are pregnant or are actively breastfeeding or planning a pregnancy within two months. (there is no concern for risk to fetus but pregnancy can alter skin pigmentation) * female volunteers who have started a new hormonal birth control agent or switched to a hormonal birth control agent within the past 60 days * individuals who have had any medical or cosmetic procedure, such as laser resurfacing, or plastic surgery to the test site (face) within the last 6 months. this includes botulinum toxin, dermal fillers, collagen or other similar cosmetic procedure * individuals who are currently using or during the past 30 days have used hydroquinone, or a retinoid such as retin a, or other rx/otc retinyl a. * individuals who have used salicyclic acid, beta hydroxy acid, vitamins a, c, e in the 14 days prior to first visit. * individuals with a known history of hypersensitivity to any ingredients to the cosmetic agent that is being assessed * individuals who are pregnant, breast feeding or planning a pregnancy. * individuals who have history of a psychological illness or condition that would interfere with their ability to understand and follow the requirements of the study at the discretion of the investigator
spinal cord neuromodulation for spinal cord injury

Conditions: Cervical Spinal Cord Injury; Tetraparesis; Tetraplegia

Summary: this study is designed to assess the strategy of using spinal cord stimulation to improve the ability to move in spinal cord injured humans.

an epidural stimulation device will be tested to determine if motor function can be improved.

Eligibility criteria:
inclusion criteria: 1. stable medical condition without cardiopulmonary disease or dysautonomia that would contraindicate hand/arm movement 2. no severe cardiopulmonary diseases such as severe bradycardia, severe autonomic dysreflexia, and/or chronic obstructive pulmonary disease. 3. no painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure sore, or infection that might interfere with upper extremity training 4. no clinically significant depression or ongoing drug abuse 5. no current anti-spasticity medication regimen 6. non-progressive sci above c5 7. must not have received botox injections in the prior six months 8. be unable to grip or move independently 9. be at least one-year post injury 10. must be at least 18 years of age 11. segmental reflexes remain functional below the lesion 12. female subjects of child-bearing potential must not be pregnant and must be using a medically acceptable method of contraception 13. no current implant(s) of neurostimulators, cardiac pacemakers, defibrillators, shunts, stents, or aneurysm clips, and must have no future exposure to diathermy following implantation 14. no coagulopathy, cardiac risk factors, or other significant medical risk factors for surgery 15. must not be involved in another clinical trial 16. must not have disorders or conditions that would require mri monitoring exclusion criteria: none as long as inclusion criteria are met.
study to describe the actual situation of hepatitis c treatment in brazil

Conditions: Hepatitis C Virus

Summary: the purpose of the study is to describe: 1) the clinical profile, past and current management of participants with hepatitis c in brazil reference centers; 2) the current situation about demographics characteristics, liver disease progression and clinical outcomes in brazilian hepatitis c virus (hcv) participants naive, in treatment and previously exposed to antiviral treatment without sustained virological response (svr).

this is an observational, non-interventional, cross-sectional, multicenter study to describe demographic characteristics, treatment performed and clinical outcomes of brazilian participants with hcv chronic infection in about 12 brazilian reference centers. it will expect that approximately 2000 participants will be enrolled in the study. analysis set will consist of participants with hcv chronic infection who are registered at the brazilian reference centers and meet all the inclusion criteria and have sufficient information to identify the diagnosis of chronic hcv infection with identification of genotype. the study related data will be collected from the medical records in the predesigned electronic case report form (ecrf).

Eligibility criteria:
inclusion criteria: * participants with diagnosis confirmed with hepatitis c infection being followed into the reference centers * there is no restriction on fibrosis stage or clinical liver disease * there is no restriction for comorbities or coinfections * diagnosis of chronic hcv infection detected by anti-hcv (elisa assays), hcv ribonucleic acid (rna) (polymerase chain reaction \[pcr\] reaction) with identification of genotype exclusion criteria: * male or female participant with age greater than or equal to 18 years * participating in another interventional clinical trial * treated participants who achieved sustained virological response (svr)

Keywords: hepatitis c virus observational brazil
validation of rehab assessments in myositis patients

Conditions: Myositis

Summary: the aim of the study is to evaluate the psychometric properties (content and construct validity, reliability, measurements error, as well as possible floor and ceiling effects) of both the assessments mmt8 and the myositis activity profile in patients with im.

this study evaluates the validity and reliability of two health related instruments that assess disease relevant functions and disabilities in patients with im: the manual muscle testing 8 (mmt8) and the myositis activity profile (map). this study is needed to determine the psychometric properties of these two assessments. provided that both the mmt8 and the map show good psychometric properties, these assessments could be used in the rehabilitation process and intervention programs of patients with im to determine progress in muscle strength and activity in daily life. methodology: reliability (test re-test study and validity (cross sectional study) of a short form of mmt 8 and a questionnaire to assess difficulties in activities of daily life (map) in myositis patients.

Eligibility criteria:
inclusion criteria: * diagnosis of polymyositis or dermatomyositis or inflammatory myositis associated disorders (e.g. scleroderma, systematic lupus erythematosus, sjögren's syndrome) * age over 18 * sufficiently understanding of german language * able to understand and follow verbal and written instructions * signed informed consent to participate in the study exclusion criteria: * diagnosis of inclusion body myositis * pulmonary hypertension * osteoporosis * severe cardiovascular and/or pulmonary disease * pain syndrome * paresis inclusion criteria aged and gender matched healthy controls (systematic lupus erythematosus, sjögren's syndrome) * age over 18 * sufficiently understanding of german language * able to understand and follow verbal and written instructions * signed informed consent to participate in the study

Keywords: reliability validity measurement error
mqx-503 applied to the hand versus nitroglycerin ointment applied to the chest: a pharmacokinetic comparison

Conditions: Raynaud's Phenomenon

Summary: the purpose of this clinical study is to compare the pharmacokinetic profiles of a topical cream formulation of 0.9% nitroglycerin, mqx 503, and nitroglycerin ointment 2%, usp.


Eligibility criteria:
inclusion criteria: * 18 to 50 years of age * subjects who do not take any prescription medication or who can safely discontinue use prior to visit 1. * negative pregnancy test for fertile women and agree to use effective contaception throughout the study. exclusion criteria: * subjects who can not safely discontinue current prescription medications. * subjects who have a known allergy to nitroglycerin or common topical formulation ingredients. * subjects with an unstable medical problem. * subjects who, within the past three months, have had either a myocardial infarction, uncontrolled congestive heart failure, unstable angina, uncontrolled hypotension, or uncontrolled hypertension. * subjects who participated in a study of any investigational drug or device within four weeks prior to visit 1. * subjects who have screening laboratory values which are outside the normal range and which are considered to be clinically significant to the investigator. * subjects who have had major abdominal, thoracic, or vascular surgery within six months of visit 1. * subjects with non-epithelialized skin lesions or interfering skin conditions at time of screening in the area where either study medication is to be applied. * pregnant or nursing women. * women of childbearing potential who are unable or unwilling to comply with the contraceptive requirements during the study period.

Keywords: healthy volunteers
bone mineral density (bmd) in hiv infection

Conditions: Osteopenia; Osteoporosis

Summary: osteopenia and osteoporosis are increasingly reported in hiv-infected patients, and appear to be more frequent than in general population. however, pathogenesis remains unclear, and published studies still give non concordant results. we therefore started a prospective study, to assess the potential role of arv in the occurrence of osteopenia and osteoporosis. bmd evolution over a 2-years period of follow-up, will be compared between patients starting arv therapy, and subjects without haart (no indication of treatment). a correlation between bmd and several factors will be looked at (see below). this study with individual direct benefice, is conducted in 3 outpatients clinics (strasbourg, colmar, mulhouse) in collaboration with the rheumatologic teams. 60 patients are planned to be included over a 3-years inclusion period


Eligibility criteria:
inclusion criteria: * hiv-1 infected men, caucasian, age \> 18 years, arv-naïve exclusion criteria: * hiv-infected women, subjects \< 18 years, non-caucasian men, arv-experienced patients, subjects not able or willing to give informed consent, endocrine disease or treatment which could affect bone metabolism

Keywords: osteopenia osteoporosis bone mineral density hiv infection bone metabolism treatment naive
effectiveness transfer energy capacitive and resistive therapy in patients with carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome; Energy Transfer Capacitative and Resistive Therapy

Summary: objective: the aim of this study was to evaluate the effect of transfer energy capacitive and resistive (tecar) therapy on pain, symptom severity and function in patients diagnosed with carpal tunnel syndrome (cts) based on clinical and electromyography (emg) findings and to compare it with ultrasound therapy (us). methods: a total of 42 patients aged between 18 and 65 years, were randomly divided into two groups; group 1, us therapy 5 minutes intermittently for 2 weeks, 5 times a week, for a total of 10 sessions, group 2 tecar therapy 5 min capacitive (cap) and 10 min resistive (res), 3 days a week for 2 weeks, for a total of 6 sessions. both groups received paraffin therapy and wrist orthosis. all patients were evaluated using the visual analog scale (vas) for pain and paresthesia levels, the boston carpal tunnel questionnaire (bctq) for symptom severity and functional levels. additionally, median nerve csa was measured by ultrasound, at the baseline, post-treatment, first and third months.


Eligibility criteria:
inclusion criteria: * 18 years of age and over * had pain and numbness in their hands for more than 3 months were evaluated * patients diagnosed with mild and moderate cts by emg exclusion criteria: * metabolic, rheumatic, or neurological diseases that could affect the median nerve cross-sectional area (csa) * patients who had previously undergone surgery on the wrist, * oncology patients, * pregnancy, * pacemakers.

Keywords: carpal tunnel syndrome tecar therapy median nerve csa
a randomized controlled trial study comparing adnexal surgery by vnotes or laparoscopy

Conditions: Ovarian Cysts; Laparoscopic Gynecologic Surgery; vNOTES

Summary: the aim with the study is to compare postoperative pain after vnotes adnexal surgery versus laparoscopic adnexal surgery. women aged 18 and above with an indication for adnexal surgery for benign gynecological pathology or prophylactic reasons will be able to participate. after surgery the participants will answer a questioner, twice a day in seven days, about postoperative pain and how many units of analgesics they used. adnexal surgery is one of the most common surgical procedures performed in women and can either be performed to treat pathology as ovarian cysts or prophylactically in case of hereditary genetic alterations. a laparoscopic technique is currently considered as gold standard for adnexal procedures. the latest advancement in minimally invasive surgery is vnotes (vaginal natural orifice transluminal endoscopy), in which the entrance to the abdomen is performed by an anterior or more commonly posterior colpotomy rather than via the abdominal wall. the notable trial was a rct showing that vnotes adnexectomy was non-inferior to laparoscopy for successful removal of benign adnexa without conversion (baekelandt). vnotes adnexectomy had shorter surgical time, less use of analgesics and lower self-assessed vas scores the first week post-operatively. the aim with our study is to compare postoperative pain after vnotes versus laparoscopic adnexal surgery.


Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the trial. * female aged 18 years or above. * diagnosed with adnexal pathology or subject for prophylactic bso. exclusion criteria: * female participant who is pregnant or planning pregnancy during course of the trial. * scheduled elective surgery or other procedures requiring general anaesthesia during the trial. * any other significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial. * patients taking opioids or other painkillers routinely pre-operatively. * patients with chronic pelvic pain. * patients with surgical contraindication; previous hysterectomy, history of rectal surgery, suspected or confirmed endometriosis, suspected malignancy, suspected obliteration of the pouch of douglas following severe pid or other causes, active lower genital tract infection, pregnancy. * failure to provide written informed consent prior to surgery

Keywords: adnola - a randomized controlled trial study comparing adnexal surgery by vnotes or laparoscopy
gut-brain axis, brain function, and behaviour.

Conditions: Prebiotics; Anxiety; Humans; Magnetic Resonance Imaging; Decision Making; Emotion; Cortisol

Summary: the aim is to test if dietary supplementation with prebiotics reduces measures of anxiety in healthy human participants with high self-reported levels of anxiety. study will test for an effect on behavioural, neuroendocrine and brain imaging markers of anxiety.


Eligibility criteria:
inclusion criteria: * trait anxiety levels \> 40 on stai trait inventory * participant is willing and able to give informed consent for participation in the study * not currently taking any psychoactive medications exclusion criteria: * pregnant participants * no contraindications to prebiotic administration * antibiotic, probiotics and/or prebiotic treatment in at least the two previous months. * participants who are taking any other food supplements that, in the opinion of the investigators, may affect the results. * participants who are taking any medications that, in the opinion of the investigators, may affect the results. * any significant change in diet which, at the discretion of the investigators, may affect the results. * participants who have recently participated in another research trial which, at the discretion of the investigators, may affect the results. * a history of dementia, traumatic brain injury or stroke. * anyone who is unable to perform the behavioural tasks. * current use of any psychoactive medication. * current use of psychological treatment. * anyone who does not have adequate understanding of english, sufficient to give informed consent. * any person who has a history of drug abuse or a previous history of a neurological, or has a history of neurosurgical procedure is excluded as they may be at increased risk of epilepsy and data collected may be influenced by their condition. * anyone with any metal implants or implantable device would be excluded from any brain imaging studies as indicated by the mri safety screening form.
the effect of task-oriented training in patients with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: it is reported that 85% of ms patients have gait disturbance, 87.9% balance, 35-90% fatigue and 45-60% cognitive problems. rehabilitation approaches based on the motor control systems model, the plasticity concept, the motor learning principles, have been found to be effective for solving these problems. with these rehabilitation approaches, it is aimed to develop the ability of the person to meet the task and environmental demands and to realize the highest quality and the right function with maximum potential by consuming the least energy in different environmental conditions of different tasks. "task-oriented training" may be one of the most effective among the evidence-based rehabilitation approaches for these goals. the purpose of this study is to determine the effect of "task-oriented training" on the physical and cognitive functions in patients with multiple sclerosis.

the study was designed as a randomized, controlled, single-blind trial. the patients will be randomly assigned to two groups, the "task-oriented training" group, and the control group. "task-oriented training" consisting of 10 different motor tasks including lower extremity and upper extremity activities will be applied to the training group twice a week for 6 weeks. the control group will be taught relaxation exercises and will be asked to perform the exercises 2 times for 6 weeks at home. statistical analyses will be performed using the spss software version 15 (spss inc. chicago, il, usa). the pre-training and post-training measurements of groups will be compared with the wilcoxon test. the significance level was set at p\< 0.05.

Eligibility criteria:
inclusion criteria: * participants who are ambulatory and volunteer to participate to the study, in a stable phase of the disease, without relapses in the last 3 month, with an edss between 2-5,5. exclusion criteria: * participants who have orthopedic, vision, hearing, or perception problems * patients who have any cardiovascular or pulmonary disease in which exercise is contraindicated

Keywords: multiple sclerosis task-oriented training physical performance cognition
activation of mirna and proteins after acute experimental pain. (mirna: micro rna)

Conditions: Hypertonic Saline; Isotonic Saline

Summary: in this experiment, the investigators would like to test the following: 1. does acute pain induced by hypertonic injection cause changes in plasma mirna and protein expression ? 2. can these canges correlate with the development of local hyperalgesia? 3. how does the plasma mirna expression change over a duration of 24 hours post pain induction ? 4. which mrna targets are potentially affected by acute pain?


Eligibility criteria:
inclusion criteria: * healthy men and women in the age 18-80 years * speak and understand english exclusion criteria: * acute and chronic pain * pregnancy or breastfeeding * drug addiction defined as the use of cannabis, opioids or other drugs * present or previous history of neurological, dermatological, immunological, musculoskeletal, cardiac disorder or mental illnesses that may affect the results (e.g. neuropathy, muscular pain in the upper extremities, etc.) * lack of ability to cooperate * current use of medications that may affect the trial, such as antipsychotics and pain killers as well as systemic or topical steroids and anti-inflammatory drugs. * skin diseases * consumption of alcohol or painkillers 24 hours before the study days and between these * participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)