Kornimate/medical-research-clean huggingface dataset:
cervical activation during elastic and manual resistance

Conditions: Cervical Pain

Summary: cervical pain is a condition that affects 14.6% of all adults annually. of this annual prevalence, 37.3% experience persistent neck pain with periodic recurring episodes. the purpose of this study is to compare muscle activation patterns of the cervical musculature during exercises with elastic versus manual resistance in a neck pain and asymptomatic populations. methods: a convenience sample of 15 healthy, physically active participants and 15 current patients diagnosed with non-radicular cervical pain will be recruited. exclusionary criteria will include: current cervical or upper extremity injury (healthy group), history of neck surgery, corticosteroid treatment within the last two weeks, and radicular signs or symptoms. surface electromyography will be used to quantify the activity level of the bilateral scm, as, cervical paraspinal (cp), and the upper trapezius (ut) muscles while performing a series of 6 exercises with elastic resistance using thera-band® resistance bands and manual resistance. the area will be prepped and surface electrodes placed on the corresponding muscles. the movement will be standardized by using the peak activation (pa) of each muscle during full flexion-extension movement to create a percentage of peak activation (%pa). the testing battery will consist of 6 exercises with elastic resistance and manual resistance, totaling 12 different trials. each trial will involve 5 repetitions, each held for 5 seconds. the exercises will include cervical: extension, flexion, left rotation, right rotation, left side bending, and right side bending. the men will use the green and women will use the red thera-band® resistance band. the order of exercises will be randomized in to two parts to minimize the effect of fatigue. first, cervical flexion and extension with manual and elastic resistance will be randomized. secondly, the remaining 8 exercises will be randomized. following each exercise, the patient will rate their perceived level of exertion on the thera-band® resistance intensity scale for exercise (rise).


Eligibility criteria:
inclusion criteria: * healthy physically active subjects (healthy group) * patients diagnosed with non-radicular cervical neck pain (neck pain group) * 18-65 exclusion criteria: * current cervical or upper extremity injury (healthy group) * history of neck surgery * corticosteroid treatment within the last two weeks * radicular signs or symptoms

Keywords: sternocleidomastoid neck pain emg perceived exertion thera-band cervical paraspinals
project whade: a partner-based physical activity program for women

Conditions: Hypertension; Type 2 Diabetes; Metabolic Syndrome; Smoking; High Cholesterol; PreDiabetes; Prehypertension

Summary: this study is designed to test the feasibility and acceptability of a new method for supporting physical activity among women ages 40-65 who have risk factors for cardiovascular disease. each participant receives a trained physical activity coach and a physical activity partner; the partner is another woman in the program. partners communicate with each other between weekly coaching sessions to provide support for physical activity behavior change.

the purpose of this study is to test the feasibility and acceptability of a new method for supporting physical activity in women ages 40-65 who have risk markers for cardiovascular disease. the primary goal is to understand perceptions of support and communication patterns between partner dyads of women in midlife (ages 40-65). the creation of these partner dyads is a promising method for promoting social support and physical activity for this population. understanding how partners communicate with one another throughout this intervention study will give insight into how women in this population maximize benefits from partnership through communication and shared experiences (e.g., age, gender, cardiovascular disease risk, interest in being more physically active).

Eligibility criteria:
inclusion criteria: * one or more of the following health conditions: smoking (current or quit in the last 3 months), or a physician diagnosis of prediabetes or type 2 diabetes, prehypertension or hypertension (high blood pressure), hypercholesterolemia or hyperlipidemia(high cholesterol), or metabolic syndrome * engaging in less in less than 6500 steps per day or less than 90 minutes of structured exercise per week * access to personal mobile device * fluent in english exclusion criteria: * pregnant or intend to become pregnant in the next 9 weeks, * medical or psychiatric situation that hinders the ability to perform physical activity * none one of the following cardiovascular risk behaviors or conditions: smoking, diagnosed prediabetes/type 2 diabetes, prehypertension/hypertension, high cholesterol, or metabolic syndrome * not fluent in english, * no access to a personal mobile device

Keywords: social support physical activity
effect of exercise and phytoestrogen on bone, metabolic syndrome criteria and complaints of the early menopause

Conditions: Bone Diseases; Metabolic Syndrome X; Coronary Disease

Summary: the aim of the study is to compare the effect of a progressive, periodized exercise training designed to impact bone, chd-risk-factors and menopausal complaints versus the combined effect of exercise and "phytoestrogen" (cimicifuga racemosa; cr). after randomization, 84 females 1-3 year postmenopausal with no medication or illness affecting bone metabolism exercise over 12 months (eg; 42 with, 42 without cr), 42 women serve as wellness-control. three group training sessions/week will be performed in the eg. both groups will be individually supplemented with calcium and vit-d (cholecalciferol).


Eligibility criteria:
inclusion criteria: * 1-3 years early postmenopausal * caucasian race exclusion criteria: * chd-diseases * thrombosis, embolism * fractures at lumbar spine or hip * secondary osteoporosis * hyperparathyroidism * medication, diseases with impact on muscle or bone * cancer and hormone derived malign diseases * weight reduction of \> 5 kg during the last 6 months

Keywords: early menopause exercise phytoestrogen bone chd-risk factors
safety and efficacy of the vascular closure device (tonbridge) in hemostasis treatment of femoral artery puncture

Conditions: Vascular Closure; Endovascular Procedure; Hemostasis; Femoral Artery; Puncture

Summary: the purpose of this study is to verify the safety and efficacy of the vascular closure device (tonbridge) in hemostasis treatment for femoral artery puncture.

this is a prospective, multicenter, randomized control, non-inferiority clinical trial carried out in 7 centers throughout china. 228 subjects with hemostasis of femoral artery puncture will be treated with the vascular closure device (tonbridge) or the exoseal vascular closure device (codis corporation). the primary objective of this study is to evaluate the safety and effectiveness of the vascular closure device in hemostasis treatment for femoral artery puncture.

Eligibility criteria:
inclusion criteria: * age 18-80, male or non-pregnant female; * subjects undergoing unilateral femoral artery retrograde puncture for angiography or interventional procedure; * using guide sheath ≥5f to ≤8f, and length ≤12cm in angiography or interventional procedure; * subjects or their legal guardians voluntarily participate in this study, can complete follow-ups, and sign the informed consent form. exclusion criteria: * ipsilateral common femoral artery occlusion or lumen diameter \< 5mm; * inability to walk; * allergy to contrast media; * allergy to pga or peg; subjects with a history of common femoral artery surgery, percutaneous transluminal angioplasty (pta), stent implantation, or vascular graft; * subjects with bleeding tendency, such as thrombocytopenia (platelet count \ 1.5, etc.; * subjects have taken anticoagulants for a long term before the procedure and have blood coagulation disorders; * bmi \>40kg/m\^2; * subjects receive thrombolytic therapy (such as streptokinase, urokinase, t-pa) within≤24 hours before vascular closure; * local infections or skin infections of the investigational limb; * subjects with target femoral artery dissection or aneurysm within 30 days before intervention procedure; * subjects with puncture site have been punctured through the posterior wall of the femoral artery, or have been punctured several times (≥3 times), or have bleeding or hematoma on the femoral artery puncture site during the procedure; * subjects with clinically significant peripheral vascular diseases (such as severe calcification, arteritis, stenosis, etc) near the puncture site; * women who are pregnant or breastfeeding, or men or women who plan to have a child in the next 6 months; * subjects who are enrolled in other clinical trials and don't complete; * subjects are considered not suitable for enrollment by the investigators.
use of novel sinusonic device for prevention of community acquired upper respiratory infection (uri)

Conditions: Upper Respiratory Infection

Summary: this study aims to test the safety, efficacy and potential mechanism of action of the sinusonic device on adults with upper respiratory infection (uri). sinusonic is a medical device that utilizes sound and pressure combined with normal breathing. the study will have 2 aims. aim 1 willdetermine if sinusonic decreases the number of uris experienced during an 8 week fall uri season. subjects will use an active device (positive expiratory pressure and 128 hz) or a sham device (no positive expiratory pressure and 1,000 hz) for 1 min tid for 8 weeks. aim 2 will determine if sinusonic decreases the severity and duration of community acquired viral uris. subjects will use active or sham device as above.


Eligibility criteria:
inclusion criteria: * adults 18 years or older with no transient symptoms of any uri or allergies at baseline. exclusion criteria: * any transient ent condition that may impact upper airway to include acute sinusitis or otitis. * any upper respiratory illness within last 2 weeks * tss will be measured at baseline as described above and must be \<9 for inclusion (eccles etal). * topical decongestant use in last week * current nasal crusting or history of ulceration or perforation * history of severe nose bleeding within last 3 months * known pregnancy * immunosuppressed condition or on immune modulating medications such as prednisone or chemotherapy * allergic sensitivity to silicone or any other component of device * inability to read and understand english * inability to perform treatment due to underlying medical condition
comparison of efficacy of triple regimen based on clarithromycin vs metronidazole in children

Conditions: H Pylori Gastritis

Summary: all children from 1day to 18years of age, diagnosed with peptic ulcer disease due to h pylori at pakistan institute of medical sciences, islamabad, from july 2020 to december 2021 will be included in the study. after informed written consent from parents/ guardians patients' bio data along with history and examination will be recorded on a proforma. they will be allocated into two groups, group a and group b randomly based on treatment regimen offered. group a: amoxicillin amo + clarithromycin cla + proton pump inhibitor ppi) group b: amoxicillin amo+ metronidazole met+ proton pump inhibitor ppi the history will include presenting symptoms along duration, remission of symptoms after therapy and clinical outcome will also be recorded.

helicobacter pylori is a gram-negative bacillus responsible for one of the most common infections found in humans worldwide1. in general, the prevalence is high in developing countries and the infection is acquired at a young age. most children infected with h pylori are asymptomatic. antral gastritis is the most common manifestation in children. duodenal and gastric ulcers may be associated with h pylori gastritis in 1.8 % children2. antibiotic resistance is the major cause of failure in the treatment of h pylori infection3. most of the studies worldwide confirmed an increase in macrolide resistance, while metronidazole resistance either decreased or remained stable. in a prospective multicenter european study, primarily comprised of adults, found a 31.8% resistance rate to clarithromycin and 25.7% to metronidazole in the study4. if the strain is resistant to one of the antibiotics used, treatment success will be compromised5. as a result therapies that are recommended should be based on antibiotic susceptibility testing. if this testing is not available, then clarithromycin-based triple therapy should not be used as part of first-line therapy due to high rates of clarithromycin resistance rates6 the european society for paeditric gastroenterology hepatology and nutrition/north american society for pediatric gastroenterology, hepatology and nutrition made the recommendations in 2017 for the management of helicobacter pylori in children that antimicrobial sensitivity should be obtained for the infecting h pylori to tailor eradication therapy accordingly and the effectiveness of first-line therapy should be evaluated in national/regional centers7. if the strain is susceptible to clarithromycin (cla) and to metronidazole (met), triple therapy (ppi, amoxicillin \[amo\], cla) for 14 days and doses of proton pump inhibitor and antibiotics should be calculated based on the bodyweight8. we aim to study efficacy and safety of clarithromycin vs metronidazole based triple regimen for the eradication of h pylori in children with peptic ulcer disease.

Eligibility criteria:
inclusion criteria: * 1. all children age 1-12 years having h-pylori gastritis exclusion criteria: * drug induced gastritis critically ill child

Keywords: h-pylori gastritis, eradication therapy, triple regimen
effectiveness of expectant management in the tubal ectopic pregnancy

Conditions: Ectopic Pregnancy

Summary: objectives: to evaluate if, when considering expectant management in tubal ectopic pregnancy if the complementary use of methotrexate could provide better results. we evaluate the success of treatment and the time required for titers of β-hcg to become negative. methods: a double-blind randomized study, held at the department of obstetrics unifesp. the patients will be divided into two groups: in one patients will be administered a single intramuscular dose of 50 mg/m2 of methotrexate and in the other patients will be prescribed placebo intramuscularly. the monitoring will be done by measurement of β-hcg in the 4th and 7th day. when the decline of beta-hcg titers was \> 15% in this interval, the patient was followed with weekly dosing of β-hcg until the titers become negative. the criterion of success is when the β-hcg was negative. the treatment failure occurs when surgery was necessary.


Eligibility criteria:
inclusion criteria: * hemodynamic stability * initial β-hcg \<2000 miu / ml * titers of β-hcg in decline in 48 hours before treatment * adnexal mass \<5.0 cm * desire for future pregnancy exclusion criteria: * alive embryo * ectopic pregnancy other than in tubal location * pregnancy of unknown location

Keywords: ectopic pregnancy methotrexate human chorionic gonadotropin beta subunit expectant management
homebased monitoring cardiac rehabilitation program

Conditions: Homebased Cardiac Rehabilitation Program After Ischemic Heart Disease

Summary: the current state of mobile communication and technology is a tool to support home programs for chronic disease management, useful to facilitate access to these types of programs, because the investigators could obtain telematics information about the parameters, reducing cardiovascular risk factors and cardiovascular morbidity and mortality.

the current state of mobile communication and technology is a tool to support home programs for chronic disease management, useful to facilitate access to these types of programs, because the investigators could obtain telematics information about the parameters, reducing cardiovascular risk factors and cardiovascular morbidity and mortality. once the patient qualifies for inclusion in the study and has signed informed consent it is included in a list where randomized 7 patients in the experimental group (home-based cardiac rehabilitation nuubo monitoring vest) and 7 patients are assigned to traditional cardiac rehabilitation group.

Eligibility criteria:
inclusion criteria: all of them: * age ≤ 80 years. * stable ischemic heart disease, revascularized by angioplasty or underwent surgery by coronary bypass \<= one year from the acute episode. * good cognitive level. * ability to perform aerobic exercise tape or cycle ergometer. * understand the use of a mobile smartphone or tablet. * signature of informed consent. and at least one of the following: * ventricular dysfunction by ejection fraction (fe) 40 - 50%. * functional capacity 5-7 metabolic equivalents (mets). * raising the blood pressure with the effort. exclusion criteria: * presence of malignant arrhythmias such as ventricular fibrillation outside the acute phase of acute myocardial infarction (ami) (\> 24 h after ami), ventricular tachycardia, atrioventricular block of 2nd degree and 3rd degree, atrial fibrilation (fa) in patients with wolf parkinson white, fibrillation or paroxysmal atrial flutter with response ventricular quickly and hemodynamic deterioration, premature ventricular contractions increases during exertion, paroxysmal supraventricular tachycardia uncontrolled. * previous infarcts. * hypotensive response to exercise. * myocardial ischemia valued at exercise test. * unstable angina. * nonrevascularizable disease. * poorly controlled hypertension baseline. * killip iii and iv killip. * no collaborator. * valvular heart disease associated. * pacemaker or implantable cardioverter defibrillator. * pathology of musculoskeletal, neurological or breathing that impair the ability of prolonged ambulation.

Keywords: home monitoring cardiac monitoring
noninvasive continuous blood pressure monitoring for cesarean delivery

Conditions: Cesarean Section Complications; Hypotension

Summary: noninvasive continuous blood pressure monitoring for preventing post-spinal hypotension during cesarean delivery: a randomized controlled trial

the aim of this study was to find out whether the incidence of hypotension during surgery can be reduced in the case of non-invasive, continuous blood pressure monitoring using the clearsight system in patients undergoing cesarean section under spinal anesthesia, compared to the case of using conventional noninvasive blood pressure monitoring

Eligibility criteria:
inclusion criteria: * adult mothers who are pregnant with single fetuses over 35 weeks gestational age undergoing planned cesarean delivery under spinal anesthesia exclusion criteria: * multiple fetal pregnancy * preexisting hypertension or pregnancy-induced hypertension * underlying heart disease * underlying cerebrovascular disease * known fetal anomaly * contraindicated in spinal anesthesia * any sign of onset of labor * body weight \ 90 kg * height \ 180cm * all other cases in which researchers determine to be inappropriate for this clinical trial

Keywords: noninvasive continuous blood pressure monitoring
cox-2 inhibition in radiation-induced oral mucositis

Conditions: Oral Mucositis

Summary: oral mucositis refers to ulcerative lesions of the oral mucosa that occur due to radiation therapy given for treatment of head and neck cancer. these lesions are painful, compromise nutrition and quality of life and may necessitate interruptions in radiation therapy, thus adversely affecting cancer therapy outcomes. this study examined the use of an anti-inflammatory medicine to reduce pain and severity of oral mucositis.


Eligibility criteria:
key inclusion criteria: * patients who will be receiving at least 5000 centigray (cgy) radiation therapy to at least 2 of 14 pre-defined areas in the oral cavity. * women of childbearing potential must agree to use a medically accepted form of contraception during the course of the study. women of childbearing potential must have a documented negative pregnancy test within fourteen days of enrollment in the study. * patient's willing and able to provide written informed consent for the study. key exclusion criteria: * patients with known hypersensitivity to celecoxib or other cox-2 inhibitors. * patients who have experienced asthma, urticaria, or allergic-type reactions after taking salicylates (e.g. aspirin) or non-steroidal anti-inflammatory drugs (nsaids). * patients who have demonstrated allergic-type reactions to sulfonamides. * patients with a history of gastric, esophageal, pyloric channel or duodenal ulcer disease or gastrointestinal bleeding. * patients with a history of inflammatory bowel disease (e.g. crohn's disease, ulcerative colitis) or pancreatic disease. * patients with severe hepatic impairment. * patients with advanced renal disease. * patients with a significant bleeding disorder. * patients under the age of 18 or over the age of 75. * women who are pregnant or nursing. * patients with a history of thromboembolic events including myocardial infarction, pulmonary embolism, deep venous thrombosis, transient ischemic attack and ischemic cerebrovascular accident (stroke). * patients who have had coronary angioplasty, coronary artery bypass surgery or another cardiac revascularization procedure. * patients with a history of a cardiac arrhythmia requiring anti-arrhythmic therapy, angina pectoris or congestive heart failure.

Keywords: mucositis head and neck cancer head and neck neoplasms stomatitis
interactive spaced education to optimize diabetes care

Conditions: Diabetes

Summary: investigators are conducting a randomized controlled trial to determine whether an online team-based spaced education (se) game can improve hba1c levels among these patients with diabetes (primary aim). secondary aims include determining the impact of the game on patients' pill possession ratio (ppr) of oral dm meds and their microalbumin/creatinine (m/c) ratio, ace ppr, and arb ppr.

participants will be randomized to one of two cohorts: (1) the intervention cohort will participate in an online team-based game on diabetes self-management education (dsme) and will receive a paper documents on american history, and (2) the 'attention control' cohort will participate in an online team-based game on american history and will receive a paper documents on dsme. each game would consist of 2 questions per week x 25 weeks = 50 questions total per arm. the questions are delivered via email by the qstream platform to the participants. upon clicking on a hyperlink in the email, participants select an answer that is downloaded to a server. they are then provided with the answer to and explanation of the question, along with additional educational materials. using an adaptive methodology, the spacing and content of the game material will be individualized for each clinician based on their performance. home-based testing of hba1c and m/c ratio will be conducted by patients at enrollment, 6 months and 12 months. if successful, this se game will improve diabetes management among va patients and improve patient outcomes. given the growing use of email and the internet by patients, se games could be easily expanded to a broad audience of va patients with varying health problems across the country. with content tailored to meet specific needs, se games can be utilized as tools to improve patients' clinical outcomes by bolstering their health management behaviors.

Eligibility criteria:
inclusion criteria: * patients in the northeastern veterans affairs hospital system who are taking oral diabetes medications, have a ppr\ 7.5. exclusion criteria: -

Keywords: diabetes education, patient educational technology