hospital-based diabetes prevention study in korea

Conditions: PreDiabetes

Summary: the investigators will study prevention effect of life style modification on diabetes mellitus comparing with conventional management and metformin administration.


Eligibility criteria:
inclusion criteria: 1. 30\<age\<71 2. bmi≥23 kg/m2 3. '75g oral glucose tolerance 2 hours after the test blood glucose140\~199mg/dl' or 'fasting blood sugar 110\~125 mg/dl' or 'hba1c 5.7%\~6.4%' exclusion criteria: 1. who diagnosed with diabetes mellitus or who having drugs for diabetes mellitus. 2. type 2 diabetes mellitus * who diagnosed with diabetes mellitus except for maternity period. * who have had drugs for diabetes mellitus(hypoglycemic agent or insulin) except for maternity period. * fasting glucose≥ 126 mg/dl * 75g oral glucose tolerance 2 hours after the blood glucose ≥ 200 mg/dl * hba1c ≥ 6.5% 3. who life expectancy is short. * cardiac history * history of severe cardiovascular disease within the last 6 months (cerebral hemorrhage, stroke, myocardial infarction, angina pectoris, heart failure, etc.) * systolic blood pressure \>180 mmhg or diastolic blood pressure \>105 mmhg * aortic stenosis * left bundle branch block or third degree av block * who had been diagnosed and treated for malignant tumors including leukemia and lymphoma within the last 5 years * abnormal renal function (creatinine ≥ 1.4 mg/dl (male) or ≥ 1.3 mg/dl (female) or urine protein ≥ 2 +) * anemia(hematocrit \ \ ３unl) * acute gastrointestinal disease (pancreatitis, infectious intestinal disease) * who is scheduled major surgery within the last 3 to 6 months or just after the surgery. * chronic infection (hiv, active tuberculosis, etc.) * pulmonary patients who rely on oxygen or daily bronchodilators 4. who is judged to be able to influence the clinical trial by investigator. * who can not communicate * those with psychiatric or cognitive impairment that may affect the compliance of the clinical trial * those who do not agree to the treatment group allocation by random assignment * those who participate in other studies that may interfere with the clinical trial * those who lost weight by more than 10% during the past 6 months, excluding weight loss after giving birth * those who can not have normal walking or exercise * women who are pregnant * those who are currently pregnant or who are within the last 3 months after giving birth * those planning pregnancy during the clinical trial period * those who have a history of drug and alcohol abuse (acute, chronic) within the last 2 years * those who are not appropriate or unreliable for clinical trials at the discretion of the tester 5. who taking medication or medical condition that may affect the diagnosis of diabetes * thiazide diuretics * systemic beta blockers * taking niacin for the treatment of neutropenic depression * possibility of taking or injecting a systemic steroid preparation * taking a serotonin reuptake inhibitor (ssri) for weight loss purpose. * taking medicine for weight loss * hormone status is not appropriate during thyroid hormone replacement therapy (tsh abnormal range) (if thyroid hormone therapy is stable for more than 3 months and tsh is normal, the patient can participate in) * others with other endocrine diseases (eg cushing's syndrome, acromegaly) * during treatment, fasting plasma triglyceride\> 600 mg / dl

Keywords: diabetes prevention