Kornimate/medical-research-clean huggingface dataset:
evaluation of the accuracy of the pogo score

Conditions: Intubation

Summary: a classification method describing the larynx appearance during laryngoscopy accepted by all anesthetists has not been defined yet. in one study, it was shown that anesthetists mis classed the glottis image by 50%. the most commonly used classification method is the cormack lehane (cl) classification. this classification classifies the larynx appearance during direct laryngoscopy form 1 to 4. the modified cl classification is criticized as it does not predict difficult intubation and especially grade 2 is operator dependent and partial view is not well defined. the numerical expression of the percentage of the glottic aperture (pogo = percentile of glottic opening) is another score. in this score, a pogo score of 100% accounts for full visualization of the larynx starting from anterior commissure to the posterior cartilage, while 0% indicated a complete absence of glottic opening. the use of a standard and effective classification method will facilitate and accelerate communication between anesthetists in difficult life-threatening situations such as difficult airway / difficult intubation / difficult ventilation and contribute to patient safety. the use of common terminology can also facilitate the evaluation of the performance of intubation tools. the aim of this study was to evaluate the accuracy and intra and inter rater reliability of the pogo score.

anesthesiologist will be asked to score still images of laryngeal views, which will be obtained from patients requiring intubation for general anesthesia, after obtaining written informed consent. the images of the larynx will be captured first with the macintosh blade and thereafter with the d blade. a group of independent anesthesiologist will score these images with the cormack lehane and pogo scores. the set of images will be prepared from patients with both difficult and normal airway anatomy. some images in the series will be repeated to assess intra rater variability. the anesthesiologist will be asked to rate 20 images both with the cl and pogo scores. the experience of the raters in airway management, their experience with videolaryngoscopy and scoring systems used currently when documenting videolaryngoscopy and demographic data will be also obtained. the pogo scores of the participants and investigators will be compared. the outcome of interest is the correct pogo score rate of the participants.

Eligibility criteria:
inclusion criteria: * patients receiving general anesthesia exclusion criteria: * emergency surgery

Keywords: intubation laryngeal view scoring systems larynx
effectiveness of expiratory muscle strength training for improving communication in als

Conditions: Amyotrophic Lateral Sclerosis

Summary: a tele-health treatment study for individuals with early stage als with the aim to improve communication, cough response, and respiratory strength. all participants complete a respiratory strength training program using an expiratory muscle strength training (emst 150) device from the comfort of their homes for 6 weeks.

the investigators are looking for people with early stage als to participate in a completely tele-health (no in-person visits required) treatment study examining the effects of an expiratory muscle strength training device (emst-150) on communication, cough, and respiratory strength. participants will be required to attend 2 virtual baseline assessment sessions followed by 12 additional virtual training sessions (2 per week for 6 weeks). participants should plan to be actively enrolled in the study for \~10 weeks (3 weeks of baseline monitoring followed by 6 weeks of training). participants will also be required to fill out a series of questionnaires assessing the emst's effectiveness via tele-health.

Eligibility criteria:
inclusion criteria: * diagnosis of als * within the early stages of disease progression (i.e., able to talk, breathe, and eat independently) * speaker of english * have a family member/caregiver willing to assist as needed * have access to an electronic device and internet for tele-health exclusion criteria: * a history of neurological disease (besides als) * a history of asthma or respiratory problems (e.g., copd, emphysema) * a history of head, neck, or chest surgery (except mastectomy) * a history of smoking within the last 5 years * reliance on mechanical ventilation (including cpap)
tms augmented exposure therapy

Conditions: Phobia

Summary: this study investigates the beneficial effects of prefrontal brain stimulation (with a facilitating tms protocol) before exposure therapy in acrophobic patients. the two exposure sessions were realized in virtual reality. before and after therapy, the phobic symptoms were measured on a subjective, behavioral and physiological level. the placebo-controlled single blinded study includes 50 phobic patients, which were randomized into verum or sham tms.


Eligibility criteria:
inclusion criteria: criteria for a simple phobia: specific heights exclusion criteria: objective tinnitus involvement in psychiatric treatments clinically relevant psychiatric comorbidity clinically relevant unstable internal or neurological comorbidity history of or evidence of significant brain malformation or neoplasm, head injury cerebral vascular events neurodegenerative disorder affecting the brain or prior brain surgery metal objects in and around body that can not be removed pregnancy alcohol or drug abuse history of seizures

Keywords: tms virtual reality (vr) exposure therapy tms augmentations of exposure therapy
tumor-educated platelets in venous thromboembolism

Conditions: Neoplasms; Venous Thromboembolism

Summary: among patients with a first episode of unprovoked venous thromboembolism (vte), the contemporary one-year risk of detecting occult cancer is approximately 4% to 7%. of these cases, 30% to 60% are missed by routine limited screening for cancer. rna profiling of platelets is a promising, highly accurate biomarker for cancer detection, but its clinical utility in patients with unprovoked vte is unknown. the objective of the present study is to evaluate the diagnostic accuracy of platelet rna profiling in detecting occult cancer in patients with unprovoked venous thromboembolism. secondary objectives include evaluation of other biomarkers for cancer, prediction of bleeding, and prediction of recurrent vte.


Eligibility criteria:
inclusion criteria: * first episode of objectively confirmed, symptomatic, unprovoked symptomatic pulmonary embolism and/or distal or proximal deep vein thrombosis of the leg * age 40 years or older * written informed consent exclusion criteria: * known malignant disease prior to vte defined as a cancer diagnosis or cancer treatment within the past 5 years (of note: suspected but unconfirmed cancer at diagnosis of vte is allowed); * trauma or fracture of the leg, surgical procedures, general anesthesia, or immobilization greater than 3 days within previous 3 months; * previous unprovoked venous thromboembolism; * known hereditary or acquired thrombophilia; * current pregnancy or puerperium (up to 3 months postpartum); * current estrogen therapy. * greater than 10 days after vte diagnosis; * inability for blood withdrawal at baseline; * inability or refusal to provide written informed consent.

Keywords: occult cancer venous thromboembolism tumor-educated platelets platelet rna profiling early diagnosis screening
gore flow reversal system and gore embolic filter extension study

Conditions: Carotid Stenosis; Constriction, Pathologic; Carotid Artery Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases; Pathological Conditions, Anatomical

Summary: the objective of this study is to provide an ongoing evaluation of clinical outcomes associated with the gore flow reversal system and the gore embolic filter when used for embolic protection during carotid artery stenting.

physicians will have the opportunity to select which embolic protection device, the gore flow reversal system or the gore embolic filter, to use during the carotid artery stenting procedure. this study is not designed to compare study endpoints between the two treatment arms.

Eligibility criteria:
inclusion criteria: * patient, or patient's legal representative, is able and willing to provide informed consent. * patient must be at least 18 years of age or older. * patient will be selected and treated according to the gore flow reversal system instructions for use (ifu) or the gore embolic filter ifu. exclusion criteria: * patient is contraindicated for the embolic protection device arm they are selected by the investigator to receive: either per the gore flow reversal system ifu if the gore flow reversal system is selected or per the gore embolic filter ifu if the gore embolic filter is selected if the patient is contraindicated for both arms (devices) they may not be enrolled.

Keywords: gore neuro protection system gore flow reversal system carotid artery stenosis embolic protection device reverse flow proximal occlusion device gnps parodi empire distal embolization minimizing risks of cas paes embolic filter
an efficacy and safety study of desloratadine (mk-4117) in japanese participants with chronic urticaria (mk-4117-201)

Conditions: Urticaria

Summary: this is a study to evaluate the efficacy and safety of desloratadine (mk-4117) in japanese participants with chronic urticaria. the primary hypothesis is that the efficacy of desloratadine 10 mg and 5 mg is superior to placebo as based on the change from baseline in the sum score of pruritus/itch and rash as assessed by the investigator at week 2.


Eligibility criteria:
inclusion criteria: * chronic urticaria \[rash (erythema, wheal) for more than 1 month without any known cause\] * out-patient exclusion criteria: * stimulation-induced urticaria \[physical urticaria (e.g. cold, solar, and heat urticaria), cholinergic urticaria, contact urticaria)\] * hypersensitivity to antihistamines or ingredients of a study drug

Keywords: urticaria skin diseases, vascular skin diseases hypersensitivity, immediate hypersensitivity immune system diseases cholinergic antagonists cholinergic agents neurotransmitter agents histamine h1 antagonists, non-sedating histamine h1 antagonists histamine antagonists histamine agents
the impact of oral vitamin c in prevention for post operative atrial fibrillation (poaf) in coronary artery bypass surgery (cabg) patients

Conditions: Post Operative Atrial Fibrillation

Summary: post operative atrial fibrillation (poaf) is one of the most common complications that takes place worldwide after coronary artery bypass surgeries (cabg). many studies suggest using vitamin c as an additional treatment alongside standard therapies, such as statins and β-blockers, to reduce the risk of postoperative atrial fibrillation (poaf) in patients undergoing (cabg). supplemental therapy with vitamin c may provide a more robust preventive effect against poaf compared to using statins and β-blockers due to its strong antioxidant effect. this implies that vitamin c can enhance the effectiveness of those medications used for poaf prevention by decreasing oxidative stress induced by the surgery. there are conflicting data on whether or not vitamin c as an antioxidant has a protective effect against postoperative atrial fibrillation and has a significant role in shortening length of icu and hospital stay . even in those studies that show positive relationship of vitamin c in af prevention, there is a diversity in the dosing regimen of vitamin c used among those previous studies. to the best of our knowledge, most researches were conducted predominantly within a single geographic region, such as iran, this raises the concerns about the potential bias and limits our ability to apply the findings to a broader global population. here, the investigators aimed to evaluate the effectiveness of vitamin c supplementation and to figure out which dose of vitamin c will prevent post-operative af and decrease complications such as hospital stay, pneumonia and surgical site infection among older egyptian adults.


Eligibility criteria:
inclusion criteria: * patients who underwent elective isolated on-pump coronary artery bypass surgery * age: 50 to 70 years * no history of coronary artery by pass surgery * taking maximum tolerated beta-blocker before and after surgery * normal left atrium and left ventricle dimensions exclusion criteria: * preoperative history of atrial fibrilliation * permanent pacemaker or significant bradycardia * hyperoxaluria or history of nephrolithiasis * left ventricular ejection fraction \< 40% * contraindications to beta-blocker or vitamin c. * patients with history of vitamin c consumption before surgery. * chronic kidney disease with creatinine \>2 mg/dl.
reference values and clinical screening test of diffuse noxious inhibitory controls (dnic)

Conditions: Chronic Pain

Summary: chronic pain (cp) is disabling for people triggering important costs for society. a deficit of diffuse noxious inhibitory controls (dnic) is one of the cp mechanisms. dnics are evaluated in research setting using a cpm protocol (conditioned pain modulation). there is a lack of reference values on the effectiveness of dnics. wider research on dnic will help to understand cp and to develop a clinical screening test evaluating dnics.

this study aims: 1. to establish baseline values of dnics using cpm protocol 2. to identify the variables that will be integrated in the algorithm of the clinical screening test (clinical decision rule). first the target population will be healthy volunteers, male and female, stratified by age. the reference values will be established via a non-parametric method for a standard cpm protocol in which two different pain stimuli are applied. two "stimuli tests" of the same intensity and nature (heat) will be applied before and after the application of another "conditioning stimulus" (cold water bath). the perceived pain difference between the 1st and 2nd stimuli tests will reflect the intensity of the dnics. secondly, these results will be compared to those from volunteers suffering of chronic pain. the clinical decision rule will result from clinical and paraclinical elements correlating with the amplitude of the efficacy of cpm (serum noradrenaline, intensity of pain, heart rate and blood pressure measurements, psychometric questionnaires assessing anxiety, depressive feelings and pain catastrophizing). logistic regression analysis will determine the best predictors of a cpm deficit.

Eligibility criteria:
inclusion criteria: * 18-79 years old * able to provide consent exclusion criteria: * cardiovascular disease (arrhythmia, cerebrovascular accident, infarction...) * raynaud syndrome * severe psychiatric disease (dementia, schizophrenia, psychosis, major depression) * injuries or loss sensitivity to their forearms or hands * pregnant women or in post-partum period (\<1 year)

Keywords: conditioned pain modulation (cpm) diffuse noxious inhibitory controls (dnic) pressure pain threshold (ppt) reference values clinical decision rule
comparison of spinal anesthesia adjuvant and quadratus lumborum block on the opioid requirement and perioperative pain of laparoscopic kidney transplant donor

Conditions: Laparoscopic Donor Nephrectomy; Perioperative Pain Management

Summary: this study aims to compare the effectiveness of spinal anesthesia adjuvant and quadratus lumborum block on the opioid requirement and perioperative pain on patients undergoing laparoscopic kidney transplant donor.


Eligibility criteria:
inclusion criteria: * patients aged 18-65 years undergoing laparoscopic donor nephrectomy * patients with bmi ≤ 35 kg/m2 * patients with american society of anesthesiology (asa) physical status 1-2 * patients who are willing to participate in this study exclusion criteria: * cardiovascular disease (uncontrolled stage 2 hypertension, heart failure, arrhytmia) * recent onset cerebrovascular diseasae of \< 3 months * infection on spinal site * coagulopathy * elevated intracranial pressure * severe renal or liver dysfunction * valvular heart disease or atrioventricular block

Keywords: quadratus lumborum block spinal anesthesia adjuvant laparoscopic donor nephrectomy perioperative pain management
study of an external responsive neurostimulator system on epileptiform activity

Conditions: Epilepsy

Summary: this feasibility clinical investigation is designed to demonstrate that the neuropace external responsive neurostimulator (model erns-300) can safely deliver responsive electrical stimulation automatically to affect epileptiform activity. the erns-300 is based on an implantable neurostimulator that has been adapted for acute, external use in a hospital setting.

the automated response to spontaneous epileptiform activity using the external responsive neurostimulator (erns) system clinical investigation involves subjects who are undergoing intracranial monitoring for the evaluation of epilepsy surgery and who are being monitored in the hospital's epilepsy monitoring unit. during the subject's participation, at the discretion of the investigator, the subject will be connected to the erns. the erns is an investigational device that attaches to standard intracranial electrode monitoring equipment to monitor the subject's seizure activity. it is anticipated that the subject may be connected to the erns for a period of time extending from one day to a few weeks. after the subject has enough seizures to complete their evaluation for epilepsy surgery, the physician may enable the responsive stimulation settings for the erns. the subject's participation in the clinical investigation will be complete prior to the removal of their intracranial electrodes.

Eligibility criteria:
inclusion criteria: * subject is undergoing evaluation for epilepsy surgery in a manner consistent with the surgery for epilepsy, nih consensus statement, 1990 mar 19-21; 8(2); 1-20. * subject is implanted with intracranial electrodes. * subject is under constant medical supervision while implanted with the intracranial electrodes. * subject is twelve (12) years of age or older. exclusion criteria: * subject is pregnant. * subject has a clinically significant or unstable medical condition that, in the opinion of the investigator, would make it inadvisable for the individual to participate. * subject has a progressive central nervous system disease or serious acute or ongoing systemic illnesses. * subject has an active psychosis, severe depression, suicidal ideation or psychiatric conditions associated with impaired judgment. * subject is considered at high risk, for any reason, by any of the investigators. * subject is implanted with a medical device that might interfere with the erns. (this includes, but is not limited to direct brain neurostimulators, pacemakers, implantable cardiac defibrillators, spinal cord stimulators, vagal nerve stimulators, cochlear implants)

Keywords: epilepsy neurostimulation
predicting mortality in kidney transplant recipients

Conditions: Death

Summary: accurately predicting kidney recipient risk of death has a crucial interest because of the organ shortage, the need to optimize allograft allocation by identifying high-risk patients who may not benefit from a transplant and improve the clinical decision-making after transplant to ensure that each patient survives as long as possible. however, according to a literature review the investigators performed, studies attempting to develop a kidney recipient death prediction model suffer from many shortcomings, including the lack of key risk factors, use of biased registry data, small sample size, lack of external validation in different countries and subpopulations, and short follow-up. the present study thus aimed to address these limitations and develop a robust, generalizable kidney recipient death prediction model.

the number of individuals suffering from end-stage chronic renal disease (esrd) worldwide has increased over time, exceeding seven million of patients in 2020. for individuals with esrd, kidney transplantation is the best treatment in terms of patient survival, quality of life and from a cost-effective standpoint, as compared with dialysis, even in comorbid or elderly populations. although the number of kidney transplantations performed each year has increased as well, it follows a lower pace than the increase of individuals on the waiting-list, resulting in an organ shortage. there is therefore a need to optimize allograft allocation by identifying the high-risk patients who may not benefit from a transplant and improve the clinical decision-making after transplant to ensure that each patient survives as long as possible. in this context, a kidney recipient death prediction model may improve transplant clinical practice, allowing for the ability to evaluate the individual risk of post transplant mortality, already before undergoing transplantation, thereby guiding decision making. however, developing such a model is a very difficult task, as death after kidney transplantation depends on many parameters, such as donor age, history or cause of death, imaging parameters, patients' past medical history (e.g. diabetes, dialysis duration, hypertension), patients' biological parameters, as well as the function of the allograft, which depends on patients' immunological factors, or allograft related parameters such as hla mismatches or cold ischemia time. the goal of the present study was therefore to identify the determinants of death after kidney transplantation, and to develop and validate a prediction model that would help optimize allograft allocation and post-transplant patient management, using a large, international, highly phenotyped cohort of kidney recipients with extensive data collection and long-term follow-up.

Eligibility criteria:
inclusion criteria: * adult kidney recipients exclusion criteria: * multi-organ transplantation * prior kidney transplant