Kornimate/medical-research-clean huggingface dataset:
correlation of pre- and post-operative cancer imaging techniques

Conditions: Lung Cancer

Summary: various imaging modalities are used in medical diagnosis such as mri, ct and pet. the images are sometimes acquired at different times and in different body positions, and thus need to be aligned for precise diagnosis and treatment planning. different image modalities provide complementary information about the anatomical structure under study. image registration techniques enable multimodality images to be projected onto a common coordinate system, so that these images can be aligned and spatial correspondences can be established between the images. this research project aims to investigate the information provided by functional pet and ct images about the tumour environment in lung cancer patients by registering functional pet and ct images with the pathology images acquired from the same patient. on identification of specific region of interest on the functional imaging the investigators will then be able to interrogate the tumour biology. in many cancers, the tumour environment is usually composed of a heterogeneous mass of tissue. the discrimination and classification of the carcinoma substructures is of paramount importance in the radiotherapy planning stage, as a given treatment may be more or less suitable depending on the local characteristics of the tumour. for instance, in hypoxic regions (areas inside the tumour with very low oxygen supply), radiotherapy performs poorly and strategies to intensify treatment to those areas could be investigated. this project will develop a framework for automatic registration of pathology images, which are taken from a surgically extracted lung tumour, with the corresponding pet/ct scan acquired from the patient before surgery. the registration of these images is essential for the evaluation of the performance of different pet radiotracers.


Eligibility criteria:
inclusion criteria: * patient diagnosed with primary lung cancer and are due to undergo curative surgical resection of the tumour * at least one of the tumour's major axes is larger than 30mm. * the main volume of the tumour is located within the lung tissue. * tumour is identified primarily as single mass lesion. exclusion criteria: * patient is under 18 years old.
effects of conditioning exercises and resistance interval training on post cabg patients.

Conditions: Coronary Artery Disease

Summary: coronary artery disease (cad) is a global health challenge influenced by diabetes, hypertension, and psychosocial stress, with women having a higher prevalence of coronary microvascular disease. promoting coronary collateral circulation offers an alternative coronary artery disease cad treatment. invasive interventions like pci and cabg aim to enhance coronary flow, restoring blood flow to ischemic myocardium. post-cabg challenges include depression, anxiety, and factors affecting quality of life. physiotherapy impacts heart rate variability, with virtual reality physiotherapy reducing both heart rate variability and hospital stay. cardiac rehabilitation involves lifestyle changes, enhancing functional capacity, and supporting early recovery. pre-operative respiratory muscle training improves outcomes. acute high-intensity interval exercise and mild continuous exercise benefit exercise recovery. this research compares conditioning exercises and resistance interval training effects on post-cabg patients' well-being.

the randomized clinical trial will be conducted in physical therapy department at the district headquarters (dhq) in gujranwala, employing a non-probability convenience sampling technique. the study aims to include individuals aged 40-55 years. participants in phase iv cardiac rehabilitation. both female and male will be included.exclusion criteria involve individuals with another clinical trial involving physical protocols. regular practice of physical exercise of more than 150min per week in last 3 months. decompensated heart failure. further exclusions encompass individuals who have had an acute myocardial infarction or cardiac surgery within the last 6 months, severe valvular heart diseases, uncontrolled cardiac arrhythmias, asymmetric septal hypertrophic cardiomyopathy with dynamic obstruction in the outflow pathway, musculoskeletal disorders limiting completion of the exercise program, and impaired cognitive status affecting understanding and adherence to the study protocol. group a will be given a conditioning exercise protocol while the other group b will be given resistance interval training. the difference in improvement before and after 6 weeks will be documented and compared.

Eligibility criteria:
inclusion criteria: * age 40-55 years * post-coronary artery bypass graft (cabg) patients both females and males were included * new york heart association criteria iv * hemodynamically stable patient exclusion criteria: * fall in new york heart association criteria ii iii; * hemoglobin \< 9 g/dl; * patients with peripheral or vascular problems of the lower limb, * cognitive and/or mental disorders; * exercise limiting comorbidities (primarily orthopedic, neurological condition) * enrollment in another clinical trial involving physical training protocols. * not willing to participate

Keywords: coronary artery bypass grafting conditioning therapy quality of life resistance training.
comparison of iv pca and wound infusion after repair of pectus excavatum

Conditions: Pain; Side Effects

Summary: postoperative pain management is a major problem after repair of pectus excavatum.various methods of pain management have been introduced. however, the effects of continuous wound infusion of local anesthetics through on-q catheters were not well evaluated in pectus surgery. therefore, we conducted prospective randomized controlled study to compare the effects of iv pca and continuous wound infusion after repair of pectus excavatum.

pain control is an important issue after correction of pectus excavatum. insufficient pain control leads to develop postoperative pulmonary complications, such as hypoxia, atelectasis and pneumonia. additionally, hospital length of stay could be prolonged. therefore, successful pain management is mandatory to improve clinical outcome, to decrease postoperative morbidity and to shorten the duration of hospital stay. various methods of pain management have been introduced. current typical methods for pain management include thoracic epidural analgesia and intravenous patient-controlled analgesia (iv pca). epidural analgesia has shown superior pain control effects. however, there may be rare but serious complications, such as spinal cord and nerve root lesions, epidural hematoma, or infections. iv pca is a well-established method of postoperative pain management. however, the systemic side effects of opioid, such as nausea, vomiting, sedation, or respiratory depression may occur. continuous wound infusion of local anesthetics through on-q catheters is another method for pain management. it has been used for various surgical procedures. however, the effect is not well evaluated in pectus surgery. the purpose of this study is to compare the effects of opioid-based iv pca and continuous wound infusion using a catheter.

Eligibility criteria:
inclusion criteria: * patients undergoing the repair of pectus excavatum exclusion criteria: * allergy to opioid or local anesthetics * reoperation

Keywords: patient controlled analgesia wound catheter infusion postoperative pain control pectus excavatum pain score
endothelial changes in pseudoexfoliation syndrome

Conditions: Endothelial Cell Loss, Corneal

Summary: this study aimed to evaluate the corneal endothelial cell changes before and after phacoemulsification in pseudoexfoliative patients relative to healthy adults.

pseudoexfoliation syndrome (pex) is an age related microfibrillopathy disorder characterized by the deposition of greyish white flaky exfoliative material in ocular and extraocular tissue. it commonly affects patients over 50 years old ((commonly in late 60s and 70s) with prevalence range from 0.5% to \> 30%, although it occurs in virtually every area of the world, a considerable racial variation exists in its incidence. it is relatively rare among african americans and eskimos. prevalence is high in the sami people who are indigenous of northern europe. there is also a high prevalence in arabic populations. it is also well known that patients with pxf develop cataracts early in their lives. phacoemulsification is a preferred type of cataract surgery owing to fewer complications than other types. however, it still has significant undesirable hazardous as posterior capsular rupture, vitreous loss, retinal detachment, cystoid macular oedema and posterior capsule opacification. also, it can enhance loss of corneal endothelial cells, thickness and density that may result in corneal decompensation and subsequent corneal transplantation. in patients with pxf, small pupils and weak zonular support may enhance phacoemulsification complications. non-contact specular microscope is a non-invasive method for morphological analysis of corneal density of endothelial cells, "size change" (polymegathism), "hexagonal change" (pleomorphism). therefore, this technology plays an important role in preoperative evaluation, surgical design and postoperative care.

Eligibility criteria:
inclusion criteria: 1. patient age is above50 years. 2. patient with nuclear cataract grade ii, iii. 3. clear cornea with no evidence of endothelial disease. 4. endothelial cell density more than 1000\\mm2. 5. normal anterior chamber depth and dilatable pupil. 6. no active ocular disease or inflammation. 7. pseudoexfoliative patients. exclusion criteria: 1. history of previous trauma, intraocular surgery or ocular surface infection in recent two weeks. 2. presence of any corneal opacity, endothelial disease, scarring or dystrophies. 3. pseudoexfoliative glaucoma. 4. patients age below 50 years. 5. endothelial cell count less than 1000\\mm2.
effects of percutaneous coronary intervention in patients with cardiac arrest after acute myocardial infarction: a 2-year study

Conditions: Acute Myocardial Infarction

Summary: the purpose of this study is to assess percutaneous coronary intervention 's effect on short- and long- term outcomes, and complication incidence in resuscitated victims of cardiac arrest after acute myocardial infarction


Eligibility criteria:
inclusion criteria: * underwent successful cardiopulmonary resuscitation from ca after ami exclusion criteria: * late tumor; * underwent coronary artery bypass grafting after cag; * with no attempted resuscitation.

Keywords: cardiac arrest percutaneous coronary intervention cardiogenic shock outcome
effects of the nottingham augmented reality (ar) app for arthritis hand joint pain

Conditions: Chronic Pain; Arthritis Hand; Opioid Use

Summary: the aim of this run-in design, feasibility study is to assess outcomes (including opioid-use, pain intensity, emotional function, and general physical function) for an augmented reality illusion therapy in participants with chronic hand joint pain due to arthritis.

this is a run-in design, feasibility study that uses the enrolled participants as their own control. after consenting to join the study, for the first 30 days, participants will be on their current standard of care (soc). then, for the next 30 days, the same group of participants will use the nottingham digital treatment daily. pre- and post-soc and treatment period measures of opioid use and pain, quality of life measures will be administered and measured. additionally, for qualifying participants, pre- and post-treatment functional magnetic resonance imaging (fmri) scans will be performed to assess how nottingham ar therapy affects neuroplastic changes in the supraspinal pain network associated with the therapy sessions.

Eligibility criteria:
inclusion criteria: 1. male and female adults ages 21-80 2. clinical diagnosis of chronic hand pain from arthritis or as determined by study physician 3) hand joint pain at a severity of 4 and above (on a 0 to 10 scale) daily 4) use of prescribed opioids 5) english-speaking, literate, with stable residence 5) able to operate a smartphone as evidenced by direct observation. exclusion criteria: 1. major medical illness that might confound effects of pain on function (e.g., advanced cardiac or pulmonary disease) 2. current active alcohol or substance use disorder as evidenced from medical record 3. currently active unstable psychiatric status in previous three months as measured by direct observation, patient self-report, or medical record 4. moderate or severe cognitive impairment as demonstrated by medical diagnosis or clinical observation 5. fmri exclusion only: any factors that would prevent participation in fmri

Keywords: augmented reality smartphone application digital therapeutic
clinical study to assess efficacy and safety of amiodarone in treating patients with ebola. virus disease (evd) in sierra leone. ease (emergency amiodarone study against ebola)

Conditions: Ebola Virus Disease

Summary: the purpose of this study is to evaluate the efficacy and safety of amiodarone in the treatment of patients afflicted with ebola virus disease.


Eligibility criteria:
inclusion criteria: * patient admitted to the emergency etc at goderich with a clinical diagnosis of ebola virus disease; * patient who consent to participate in the study. exclusion criteria: * negative rt-pcr tests for ebola virus * age \<2 years * state of shock upon admission * onset of fever for more than 6 days * glasgow coma scale \<12 * known contraindications to administration of amiodarone * positive for hiv antibodies.
healthy relationships and economic pathways

Conditions: Adolescent Relationship Abuse; Sexually Transmitted Infections; Pregnancy (Unwanted); Violence; Intentional Injury

Summary: the california adolescent health collaborative (cahc) brings together multiple nonprofit organizations in california's central valley to implement the healthy relationships and economic pathways (h-rep) program, which aims to increase and promote healthy relationships and stability among youth between the ages of 14 and 24.

this research project was designed to explore three core questions (rqs). research question 1:does assignment to the hre improve the knowledge and skills necessary to develop and maintain caring and supportive personal and professional relationships among youth between the ages of 18 and 24 in stanislaus and merced counties? in addition, american institutes for research (air), an independent evaluator, has been asked to answer two supplemental rqs: research question 2: does participation in the hre technology boot camp improve technological knowledge and skills as well as awareness of professional and educational opportunities among youth between the ages of 18 and 24? research question 3: does hre have the same effect on relationship knowledge and skills for youth between the ages of 18 and 24 who participate in the hre-only training as it does for youth who participate in hre plus technology bootcamp? h-rep provides a comprehensive, three-pathway program of services to (a) students in traditional, comprehensive high schools; (b) students in continuation of alternative schools (e.g. court schools); and (c) youth between the ages of 18 and 24 who are receiving employment support services from central valley nonprofit programs. the h-rep program involves formal classes in healthy relationship education (hre) and technology use, case management, and job skills training.

Eligibility criteria:
inclusion criteria: * students in traditional, comprehensive high schools; students in continuation or alternative schools; youth between ages of 18-24 who receive employment support services from central valley non-profit programs (california); residents of merced or stanislaus counties (california). exclusion criteria: * less than sixth-grade english language proficiency

Keywords: teen dating violence sexual assault reproductive coercion
genetic counseling processes and outcomes among males with prostate cancer (progen)

Conditions: Prostate Cancer

Summary: this randomized controlled trial aims to evaluate the impact of pre-test video education and post-test genetic counseling as compared to in-person pre-test genetic counseling in males with advanced prostate cancer.

participants will be randomized to either pre-test video education and post-test genetic counseling or in-person pre-test genetic counseling. outcomes evaluated are: prevalence of germline mutations, uptake of genetic testing, satisfaction with testing, knowledge of multi-gene panels, distress, result disclosure to relatives, and the impact on personal or family medical care. through this study, the investigators will learn about the inherited causes of prostate cancer, and how and when genetic testing should be offered to this population.

Eligibility criteria:
inclusion criteria: * metastatic prostate cancer (hormone-sensitive, de novo, or castration resistant) * localized prostate cancer with gleason score ≥8 * rising psa after prostatectomy or radiation with psa doubling time ≤ 6 months * persistent psa after prostatectomy for psa ≥ 0.2 ng/ml observed in testing at least 1 week apart * prostate cancer diagnosed at age ≤ 55 years * prostate cancer and a personal history of prior malignancy that does not include non-melanoma skin cancer or superficial bladder cancer. * prostate cancer diagnosis (any grade/stage) or prostate biopsy with high grade pin or small acinar proliferation and a family history potentially indicating a germline mutation (e.g. breast cancer diagnosed at age ≤ 50, ovarian, pancreatic, uterine, colorectal, prostate cancer or sarcoma, in one or more first or second-degree relatives) exclusion criteria: * previous cancer genetic testing or counseling, or prior germline multigene panel testing. previous tumor sequencing is acceptable if no genetic counseling took place. * localized prostate cancer previously treated and in remission for \> 2 years unless family history potentially indicates a germline mutation. * active hematologic malignancy (e.g. cll)

Keywords: prostate cancer genetics
sex hormone dysregulations are associated with critical illness in covid-19 patients

Conditions: Covid19; Critical Illness

Summary: males develop more severe sars-cov-2 infection related disease outcome than females. herein, sex hormones were repeatedly proposed to play an important role in covid-19 pathophysiology and immunity. however, it is yet unclear whether sex hormones are associated with covid-19 outcome in males and females. in this study, we analyzed sex hormones, cytokine and chemokine responses as well as performed a large profile analysis of 600 metabolites in critically-ill male and female covid-19 patients in comparison to healthy controls and patients with coronary heart diseases as a prime covid-19 comorbidity. we here show that dysregulated sex hormones, ifn-γ levels and unique metabolic signatures are associated with critical illness in covid-19 patients. both, male and female covid-19 patients, present elevated estradiol levels which positively correlates with ifn-γ levels. male covid-19 patients additionally display severe testosterone and triglyceride deficiencies as compared to female patients and healthy controls. our results suggest that male covid-19 patients suffer from multiple metabolic disorders, which may lead to higher risk for fatal outcome. these findings will help to understand molecular pathways involved in covid-19 pathophysiology.


Eligibility criteria:
inclusion criteria: * admission on icu * covid-19 exclusion criteria: - none

Keywords: icu, covid-19, testosteron, estradiol, sex-hormone
a study of lanadelumab in persons with hereditary angioedema (hae) type i or ii

Conditions: Hereditary Angioedema (HAE)

Summary: the main aim of this study is to compare the number of hae attacks occuring in persons using lanadelumab with the number of hae attacks before lanadelumab treatment was started. data from participants who start the study after 1 march 2021, will be collected for 24 months; data from all other participants (who started the study before 1 march 2021) will be collected for 36 months. participants will report information in a smartphone application at study start and for the next 3 months and then every 6 months until the study ends; data will also be collected by the study doctor during routine clinic visits


Eligibility criteria:
inclusion criteria: * voluntarily provision of written, signed, and dated (personally or via a legally authorized representative) informed consent to participate in the study. * initiation of treatment with lanadelumab in accordance with current product labelling. decision to start treatment with lanadelumab must be made before and be independent from enrollment in the study. * availability of information for hae attack-related variables assessed at study enrollment for the previous three months. * ability to use a smartphone for data collection in this study. exclusion criteria: * inability to provide written, signed, and dated informed consent. * participation in the study not considered appropriate by the treating physician/investigator. * contraindication to treatment with lanadelumab according to current product labelling. * pregnant or breastfeeding. * concomitant exposure to any investigational therapy (including medications not used for hae). * current or planned participation in other interventional studies.
safety and tolerability of pf-05230907 in intracerebral hemorrhage

Conditions: Intracerebral Hemorrhage

Summary: this study employs a modified continual reassessment method (mcrm) design to estimate the maximum tolerated dose (mtd) of pf-05230907, defined as a target toxicity rate of 15% based on treatment emergent thromboembolic and/or ischemic events (ties). the mcrm design utilizes bayesian methodology to continuously learn the dose-toxicity relationship, which is characterized by a parametric model. subjects with a diagnosis of ich (determined by computed tomography) will be enrolled in cohorts of 3. the total length of time planned for study participation is approximately 3 months; 6.0 hours for screening, a single dose administration with a 4-day minimum hospital confinement period and follow-up visits through day 91. severity of adverse events (aes) and serious adverse events (saes) will be graded according to the national cancer institute (nci) common terminology criteria for adverse events (ctcae) version 4.03. all subjects who receive pf-05230907 are evaluable for ties. the determination of mtd using mcrm modeling will be based on ties which occur through 7 days post-dose (day 8).


Eligibility criteria:
inclusion criteria: * ich as documented by ct scan within 6.0 hours of symptom onset * baseline ich volume \> 5ml and \< 60 ml exclusion criteria: * deep coma (glasgow coma scale \< 6) * modified rankin score \> 3 prior to ich onset * known history of schemic, vaso-occlusive or thrombotic events within 6 months prior to screening * known prothrombotic disorders * known secondary ich related to aneurysm, arteriovenous malformation, subarachnoid hemorrhage, trauma, or other causes. ct angiography, mr, or other diagnostic studies obtained as part of the standard of care may be used to assess eligibility. * known use of oral anticoagulant(s) * known use of low-molecular weight heparin or heparin

Keywords: safety, maximum tolerated dose, modified continual reassessment method, intracerebral, hemorrhage, hematoma