Kornimate/medical-research-clean huggingface dataset:
proton therapy for stage i non-small cell lung cancer (lu03)

Conditions: Non-Small Cell Lung Cancer

Summary: this is a research study to determine if hypofractionated image guided radiation therapy (hypoigrt) with proton therapy is a good way to treat early stage lung tumors for patients who will not have surgery. hypoigrt delivers higher daily doses of radiation over a shorter period of time compared with conventional radiation. this is thought to deliver a more lethal dose of radiation to the tumor and is more convenient with treatment being completed within 2-3 weeks compared to the typical 7-8 week course of conventional radiotherapy.


Eligibility criteria:
inclusion criteria: * pathologically confirmed, by biopsy or cytology, non-small cell lung carcinoma diagnosed within 3 months prior to study enrollment. * t1, n0, m0 or t2, n0, m0. (ajcc lung 7th edition) * at least 18 years old at the time of consent. * adequate bone marrow function. * medically inoperable. medically operable candidates are allowed if they refuse surgical resection. * if the patient has a large pleural effusion, it must be biopsy negative. exclusion criteria: * evidence of distant metastasis (m1) and/or nodal involvement (n1, n2, n3). * synchronous primary. * t2 tumors \> 5 cm; t3, t4 primary tumor. * previous radiotherapy for lung cancer. * concomitant local, regional, and/or systemic therapy during radiotherapy. * active systemic, pulmonary, and/or pericardial infection.

Keywords: lung cancer stage i non-small cell lung cancer proton radiation hypoigrt
en_línea. an online treatment to change lifestyle in overweight and obesity

Conditions: Overweight; Obesity

Summary: a randomized controlled trial to test the effectiveness of an online weight control program, called en_línea, comparing with a standard group therapy and a control group

this is a randomized controlled trial with three intervention arms: en_línea, standard group therapy and control group. to perform this study, 305 adults (18-65 years) with overweight type ii (27-29.9 kg/m2) or obesity type i (30-34.9 kg/m2) will be invited to participate. interventions will last 17 weeks with follow-ups 1, 3, 6 and 12 months after the post-treatment appointment. the primary outcome will be post-treatment weight loss and the maintenance during the follow-ups. secondary outcomes will be adherence rates, drop outs and quality of life. participants will be assessed before randomization and they will be sign an inform consent.

Eligibility criteria:
inclusion criteria: 1. overweight type ii or obesity type i. bmi between 27 and 34.9 kg/m2 2. age between 18 and 65 years old 3. compliance with all evaluation phases. exclusion criteria: 1. presence of several physical disease, i.e. diabetes, hypertension, cancer or metabolic disorders 2. presence of several psychological problem, i.e. depression, anxiety 3. presence of other eating disorders, i.e. anorexia nervosa, bulimia nervosa, binge eating disorders 4. use of drugs, i.e. slimming, anovulatory or psychotropic 5. pregnancy or planned pregnancy for the next six months 6. following another weight control program at the time of selection.

Keywords: "online therapy" "weight loss control program" internet
circadian rhythm of melatonin in burns

Conditions: Sleep; Burns

Summary: evaluate markers and postulated effectors of the endogenous circadian pacemaker in children admitted to the burn intensive care unit.


Eligibility criteria:
inclusion criteria: * 5-18 years old exclusion criteria: * anoxic brain injury * preexisting neurological disorder * pre-existing sleep disorder * no informed consent or hipaa release
effectiveness and safety of directional deep brain stimulation for parkinson's disease

Conditions: Parkinson's Disease

Summary: the purpose of this study is to demonstrate the safety and effectiveness of the pins deep brain stimulation (dbs) system, including the g107r/g107 ipg, l305/l306 directional leads, e204 extensions and related system components.

this is a prospective, open label, non-randomized study. the study will evaluate the clinical outcome and possible adverse effects of the directional dbs treatment. the following data will be collected: therapeutic window, movement disorder society-sponsored revision of the unified parkinson's disease rating (mds-updrs) part iii scores, parkinson's disease questionnaire (pdq-39) summary scores, total electrical energy delivered, the dosage of anti-parkinsonian medications, on time(h/d) without troublesome dyskinesia, and adverse events.

Eligibility criteria:
inclusion criteria: 1. age at the time of enrollment: 18 \~ 75; 2. idiopathic parkinson's disease; 3. patient whose symptoms are not adequately controlled by best medical therapy; 4. hoehn and yahr stage≥2.5; 5. patient whose symptoms are improved by at least 30% with levodopa challenge test; 6. must be an appropriate candidate for the surgical procedures required for bilateral dbs; 7. is willing and able to comply with all visits and study related procedures; 8. patient understands the study requirements and the treatment procedures and provides written informed consent before any study-specific tests or procedures are performed. exclusion criteria: 1. had received lesioning surgical treatment; 2. a female who is breastfeeding or of child-bearing potential with a positive urine pregnancy test or not using adequate contraception; 3. any current drug or alcohol abuse; 4. cognitive impairment (mmse≦17 for primary school education or mmse≦24 for middle school education and above); 5. any significant psychiatric problems, including unrelated clinically significant depression; 6. any history of craniocerebral injury, tumor, or severe cerebrovascular disease; 7. severe brain atrophy (confirmed by ct or mri); 8. a condition requiring or likely to require the use of diathermy; 9. abnormal blood routine or biochemical test, coagulation dysfunction, serious abnormal liver or kidney function; 10. uncontrolled high blood pressure, serious heart disease or serious medical or respiratory diseases; 11. long-term of immunosuppressive or hormone therapy; 12. other diseases requiring the stimulators; 13. a condition requiring or likely to require the use of mri; 14. participated in any other clinical trials within the preceding 3 months; 15. unwilling or unable to cooperate with the implantation of dbs system; 16. unwilling or unable to cooperate with postoperative follow-up; 17. not considered to be applicable by the investigator.
biomechanical changes in females with poly cystic ovarian syndrome

Conditions: Poly Cystic Ovarian Syndrome; Polycystic Ovary Syndrome (PCOS)

Summary: polycystic ovarian syndrome (pcos) is a prevalent endocrine disorder that causes an inversion of the normal luteinizing hormone (lh) to follicle-stimulating hormone (fsh) ratio. females with pcos also experience chronic inflammation. this hormonal imbalance and persistent inflammation can reduce muscle strength and mass. consequently, this may affect the lumbopelvic muscles, potentially leading to postural abnormalities and spinopelvic misalignment.

1.1. study design this was an observational case-control study. participants this study enrolled 95 females (52 pcos, 43 controls) who agreed to participate in this research. they signed an informed consent after explaining the existence, purpose, and advantages of the study, notifying them of their right to refuse or withdraw at any time. patients were excluded from the study if they suffered from skeletal deformities (one case), had previous spinal surgeries (one case), had leg length discrepancy (one case) and two cases received hormone replacement therapy

Eligibility criteria:
inclusion criteria: * patients were referred by the gynecologist, based on rotterdam pcos diagnostic criteria in adults (14), having irregular menstrual cycles (less than 8 menstrual cycles/year or more than 35 days between cycles), painful menses and premenstrual abdominal bloating, and headaches. exclusion criteria: * were excluded from this study if they were obese with bmi \> 30 kg/m2 (obesity induces an increase in anterior pelvic tilt and increased sacral inclination) (15), suffered from musculoskeletal deformities, previous gynecological and spinal surgeries, spinal deformities, leg length discrepancy, orthopedic and neurological disorders, receive hormone replacement therapy (affect functional biomechanical properties by increasing tensile stiffness in the uterosacral ligament and decreasing it in the round ligament)

Keywords: biomechanical changes spinopelvic alignment polycystic ovarian syndrome hormonal imbalance low-grade inflammation
effects of adsc therapy in women with pof

Conditions: Premature Ovarian Failure

Summary: the purpose of this study is to determine whether adipose derived stem cells are effective in the treatment of premature ovarian failure (pof). stem cell transplantation has been reported to rescue ovarian function in a pre-clinical mouse model of chemotherapy-induced pof; however, maintaining the survival of transplanted cells in human ovarian tissues to enable the pof patients regain ovary function over the long-term and achieving a successful pregnancy remain a troublesome issue. in this study the investigators are aiming to determine whether the cd29+/cd44+ human adipose derived stem cells could later enable ovaries produce mature oocytes.

the purpose of this study was to explore the therapeutic potency of the adipose derived stem cells (adsc) transplantation for premature ovarian failure (pof) women underwent autologous fat transplantation. the serum of each patient were kept and sent for laboratory test before the surgery. 100ml fat was harvested from the abdomen of pof patient using abdominal fat abortion. and adsc were isolated and cultured in vitro using autologous serum. the biomarkers of adsc, cd29 and cd44, were detected in the adsc cultures using flow cytometry detection. the adsc were then transplanted directly into bilateral ovaries when cells reach a density of 5-10×106. the clinical conditions of patients were examined at 1, 2, 4 and 8 weeks after the transplantation. ovarian functions were evaluated by follicle diameter and sexual hormone levels. the follicle number was counted and radiology data were kept for future analysis. to ensure high rate of pregnancy, intercourse under medical guidance may be suggested and hormone replacement treatment may be taken to help the patients conceive. main outcome measure(s): serum fsh,lh,e2 levels, recurrence of menstruation, antral follicle diameter,and pregnancy.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of premature ovarian failure * patients show no response to drug treatment * willing to receive follow up * willing to conceive a baby * age between 20 to 39 exclusion criteria: * patients with few abdominal fat * patients with chromosome abnormalities * patients with congenital ovarian malformations * patients with severe endometriosis * patients with thyroid dysfunction * patients with pregnancy contraindications * patients with hormone replacement therapy contraindications * patients with liposuction contraindications * past history of ovarian tumors or after radiotherapy * can not take the follow-up, or want to take other treatment during the follow-up period * patients with immune system diseases

Keywords: pof
dosing of methadone for spine surgery

Conditions: Pain, Postoperative

Summary: this study compares two methods of dosing methadone for complex spine cases

patients with spine surgery experience a significant amount of pain that can interfere with healing, rehabilitation and contribute to morbidity in the post-operative period. this study will compare post-operative opioid requirement at 24 and 48 hours to determine if methadone given in small aliquots until respiratory depression can act as a self-control to determine the correct dose required.

Eligibility criteria:
inclusion criteria: 1. patients must consent to participate and sign the irb-approved informed consent prior to beginning any study specific procedures. 2. at or between the ages 18 to 75 years. 3. undergoing multilevel thoracic, thoracolumbar and/or lumbar spine surgery with instrumentation and fusion. exclusion criteria: 1. methadone or buprenorphine use. 2. morbid obesity with bmi\>40 kg/m2. 3. chronic renal failure with creatinine\>2.0 mg/dl. 4. liver failure as determined by cirrhosis or history of fulminant hepatic failure. 5. current or historical alcohol abuse. 6. current or historical drug abuse. 7. patients with history of prolonged qtc, as defined as a qtc value \>450 ms in males and \>460 ms in females. 8. patients with asa status iv or v. 9. surgical diagnosis including spine tumor, infection, or trauma. 10. in the principal investigator's opinion is not a candidate for the study. 11. unwilling to sign the informed consent form.

Keywords: post-operative pain spine surgery methadone opioid
endoscopic mucosal resection for the diagnosis of a-ganglionosis, a controlled prospective trial (edge trial)

Conditions: Constipation; Hirschsprung Disease

Summary: patients undergoing routine rectal suction biopsy will undergo as part of the study an additional endoscopic mucosal resection. the biopsy results will also be correlated with patient's clinical data including clinical history, bristol stool scale, anorectal manometry results, and sitz marker studies. cost and recovery time will be compared.

background: adult and pediatric patients presenting with chronic constipation and/or motility disorders may be referred for rectal biopsy to rule out aganglionosis or hirschsprung's disease. the traditional diagnostic test, rectal suction biopsy, is a blind technique and is insensitive in confirming the diagnosis. frequently, patients require subsequent referral for a surgical full thickness biopsy. hypothesis: endoscopic mucosal resection (emr) will improve the diagnostic yield for aganglionosis and decrease the need for subsequent surgical full thickness biopsy. methods: this is a prospective, single center, controlled investigation of emr for the diagnosis of colonic aganglionosis / hirschsprung's disease. patients who are offered rectal suction biopsy will be offered enrollment. enrolled patients will have one additional procedure (emr) at the time of their rectal suction biopsy. specimens will be analyzed pathologically for size, submucosal tissue adequacy, the presence of ganglionic tissue, and positivity by acetylcholinesterase staining. the adequacy of the tissue specimen, the proportion of diagnostic specimens, and the proportion of patients that would have required subsequent referral for full thickness biopsy, will be compared. variable such as cost and recovery time will be compared. biopsy results will be compared with patient's pre-endoscopy clinical data including their history of constipation, results of sitz marker studies, bristol stool scale, and anorectal manometry. results: the primary outcome variable will be the proportion of patients with a diagnostic specimen in each group. secondary outcome variables will include the size of the specimen, the presence of ganglionic tissue, the presence of submucosal tissue, and the positivity of the acetylcholinesterase stain. the biopsy results will also be correlated with patient's clinical data including clinical history, bristol stool scale, anorectal manometry results, and sitz marker studies. cost and recovery time will be compared. discussion: the proposed investigation may demonstrate that a simple endoscopic test, which uses direct visualization, can improve the diagnostic yield of rectal biopsies for hirschsprung's disease, and spare patients an additional surgical full thickness rectal biopsy.

Eligibility criteria:
inclusion criteria: * 10 years of age or older * offered rectal suction biopsy exclusion criteria: * any contraindication to general anesthesia or conscious sedation * contraindication to endoscopy * untreated or unmanageable coagulopathy * thrombocytopenia (\<50) * inability to provide informed consent.

Keywords: constipation hirschsprung disease
copd patients diagnosed with gerd,copd exacerbations after treatment with high dose ppi

Conditions: Gastroesophageal Reflux; Chronic Obstructive Pulmonary Disease

Summary: the purpose of this study is to determine which copd patients have gerd and if copd patients with gerd treated with high dose lansoprazole for 1 year decreases the frequency of copd exacerbations compared to the previous year without treatment.

gastroesophageal reflux disease (gerd) is a common esophageal disorder with 40% of the us adult population experiencing symptoms monthly. pulmonary diseases associated with gerd may include pneumonia, pulmonary fibrosis, asthma, or chronic bronchitis. the latter may be a manifestation of chronic obstructive pulmonary disease (copd), suggesting gerd as a risk factor for acute exacerbation of copd. acute exacerbations of copd are a major cause of morbidity and mortality in patients with the disease. recent work suggests that copd patients with a minimum of weekly reflux symptoms have an increased number of copd exacerbations that those who are either asymptomatic or have gerd symptoms less than once a week. on this basis, we theorized that in patients with copd, who also have gastro esophageal reflux disease are at increase risk for acute exacerbations of copd. to test this question, we will determine which copd patients have gerd by 24 hour ph testing, treat their gerd with esomeprazole or lansoprazole for 1 year, and compare the number of copd exacerbations during the treatment period to the previous year.

Eligibility criteria:
inclusion criteria: * diagnosis of copd * forced expiratory volume/forced vital capacity ratio (fev1/fvc) of \< 70% on pulmonary function testing * age \> 40 years * \>20 pack year history of smoking exclusion criteria: * presence of the following disorders: respiratory disorders other than copd, known esophageal disease such as cancer, achalasia, stricture, active peptic ulcer disease, zollinger-ellison syndrome, mastocytosis, scleroderma, or current abuse of alcohol defined as greater than three alcoholic drinks per day.

Keywords: gastro esophageal reflux disease (gerd) chronic obstructive pulmonary disease (copd)
to evaluate the correlation between the results of specific gene testing and the efficacy of targeted therapy in patients with nsclc

Conditions: Non Small Cell Lung Cancer

Summary: evaluated the correlation between the qualitative test results of xiamen aide the gene test specified by the test reagent and the efficacy of relevant targeted drugs in patients with non-small cell lung cancery, and the research data is used to support the registration and marketing of the assessment reagent


Eligibility criteria:
inclusion criteria: * 1)≥18; * 2) advanced non-small cell lung cancer confirmed by histopathology; * 3) patients with nsclc who have previously or are taking gefitinib (first-line therapy) or osimertinib (post-tki resistance) or crizotinib monotherapy, and the response to treatment can be assessed; * 4) have sufficient ffpe tissue samples within 5 years: 5 large specimens/case; there were 10 puncture specimens/case exclusion criteria: * 1) combination therapy with chemotherapy/radiotherapy/other targeted drugs/immunotherapy drugs; * 2)maintenance therapy if the disease does not progress after treatment with other antitumor methods
prospective evaluation of sars-cov-2 antibodies levels in a vaccinated population of valle de aburra

Conditions: COVID-19

Summary: recent research evidence shows that levels of antibodies acquierd post vacunation against sars-cov-2 decrease over time as well as the efficacy to control the infection, additionally in a multicenter study carried out in 2020 were evidenced differences in the time it took to decrease the antibodies according to the type of vaccine, defined as mrna or other types of vaccine. in this study , the variation of the sars-cov-2 antibody levels in patients from valle de aburrá will be correlated according to the covid-19 vaccine received.

after being informed about the study, all patients giving written informed consent will undergo a serial igm -igg covid-19 antibodies blood test and sars-cov-2 pcr by nasopharingeal swab, that will be taken at the beginning of the study and mensually for two months. during the study will be done an active search for sars-cov-2 infections in the vaccinated people cohort, and if it is posible to characterize the variant of sars-cov-2 in participants previously vaccinated against this pathogen. the main objective of this study is to describe the pattern of antibodies blood test based in the type of vaccine and correlated the pattern of antibodies sars-cov-2 levels in a population of valle de aburrá.

Eligibility criteria:
inclusion criteria: * adult over 18 years old * the vaccinated patients to be included must have received a complete vaccination scheme for covid-19 according to the ministerio de salud y protección social de colombia * sars-cov-2 infection in the last 2 months, verified by rtpcr test exclusion criteria: * immunocompromised patients * immunosuppressive treatments, chemotherapy or antiretroviral therapy * outpatient anticoagulant therapy * for vaccinated people (groups 1 and 2): if have had covid-19 infection in the last 6 months

Keywords: laboratory biomarkers health condition covid-19 antibodies level vaccinated people
videoconferencing between ambulances and physician at the emergency medical dispatch center, effects on on-site patient treatment and patterns of referral

Conditions: Acute Illness; Acute Injury

Summary: the prehospital resources are limited. the emergency medical dispatch center (emdc) is manned by qualified health care personnel around the clock. the investigators believe that the emdc is an unexploited resource in the prehospital treatment of patients. by the use of videoconferencing the investigators will activate this resource. mobile videoconferencing between ambulances and physician at the emdc enables patient consultation at a distance. video consultation between patient and the physician at the emdc can take place when the patient is at home or in the ambulance. the primary aim of this study is to examine the effect of video consultation between physicians at the emdc and patients receiving treatment by ambulance personnel on the number of patients receiving final treatment on-site in the pre hospital setting.


Eligibility criteria:
inclusion criteria: * less ill/slightly injured patients receiving prehospital care by ambulance personnel exclusion criteria: -

Keywords: telemedicine emergency medical dispatch prehospital care video conference
randomized trial of exemestane versus continued tamoxifen in postmenopausal women with early breast cancer

Conditions: Breast Neoplasms

Summary: to compare the sequential administration of exemestane with administration of further tamoxifen until 5 years in postmenopausal women with operable breast cancer who have already received 2-3 years of adjuvant tamoxifen, in terms of disease-free survival (dfs), overall survival (os), incidence of contralateral breast cancer and long-term tolerability.


Eligibility criteria:
inclusion criteria: * postmenopausal women with histologically or cytologically confirmed primary breast adenocarcinoma, receiving tamoxifen and have been treated with tamoxifen continuously for between 2 and 3 years and one month, and still free of disease exclusion criteria: * unresectable breast cancer * er negative primary tumor