Kornimate/medical-research-clean huggingface dataset:
a trial to evaluate efficacy and safety of the combination therapy of genexol®-pm plus carboplatin® compared to genexol® plus carboplatin® as a firstline treatment in subjects with ovarian cancer

Conditions: Ovarian Cancer

Summary: the purpose of this study is to evaluate efficacy and safety of the combination therapy of genexol®-pm plus carboplatin® compared to genexol® plus carboplatin® as a firstline treatment in subjects with ovarian cancer.


Eligibility criteria:
inclusion criteria: 1. subjects who aged 18 years or older 2. subjects whose written informed consent was obtained complying with the local regulatory requirements prior to their participation in the trial 3. subjects who have histologically or cytologically confirmed unresectable or metastatic epithelial cancer of the exocrine pancreas. high-quality contrast-enhanced ct scanning is required to evaluate resectability. measurable disease is not required. exclusion criteria: 1. subjects who have received prior radiation therapy (xrt) for pancreatic cancer unless progression was documented after xrt and 6 weeks have elapsed between completion of xrt and start of trial medication. 2. subjects who have had systemic treatment such as chemotherapy or immunotherapy, for pancreatic cancer. however, prior use of chemotherapy, e.g. 5-fu or capecitabine, for radiation sensitization is allowed. if gemcitabine was given in the adjuvant setting, only subjects relapsed with cancer after 6 months of completing the last dose of gemcitabine can participate in the trial. 3. subjects who have had a major surgery within 2 weeks prior to the screening/baseline visit
efficacy of extended-release, once daily tramadol for post operative analgesia in shoulder arthroscopy

Conditions: Pain; Vertigo; Nausea; Pruritus

Summary: the investigators hypothesize that the use of tramadol will reduce pain and analgesic consumption after arthroscopic shoulder surgery.

the purpose of the study was to evaluate the efficacy of tramadol long acting for post operative pain in patients who had an arthroscopic shoulder surgery in ambulatory setting in comparison with a placebo. the intensity of pain was evaluated on a visual analog scale as the quantity of hydromorphone taken by patients, and the side effects during the first 72 hours.

Eligibility criteria:
inclusion criteria: * aged more than 18 year old * arthroscopic shoulder surgery on interscalen block * able to understand the protocol * inform consent signed exclusion criteria: * chronic pain or chronic used of narcotics * use of imao * use of isrs * pulmonary chronic disease

Keywords: tramadol shoulder surgery pain interscalen block buprenorphine/hydromorphone [va drug interaction]
detection of loco-regional invasion of cervical cancer with 7 tesla mri

Conditions: Cervical Cancer

Summary: background of the study: the accurate assessment of local cervical cancer spread (i.e. invasion) is of clinical importance for staging and treatment considerations. for example, if parametrial invasion is absent, radical surgery is the treatment of choice for tumors less than 4cm in diameter. however, if such invasion is present, the patient has become inoperable and (chemo)radiotherapy is warranted. unfortunately, regular 1.5t mri as a part of staging work-up has a limited accuracy for detecting loco-regional tumor invasion. due to relatively frequent false-negative findings a risk of understaging and under-treatment occurs. for such cases adjuvant treatments with (chemo)radiotherapy are indicated after the initial surgery, causing increased morbidity and treatment associated risks. for higher stages, with primary (chemo)radiotherapy, a more reliable mri based delineation of local tumor spread could enable individualized dose(volume) and field modifications. hypothesis/aim of the study: to develop and in vivo optimize t2w ultra high field (7t) mri sequences, which use a combination of an endorectal and external coil, to image the (para)cervical area for assessment of the loco-regional tumor status in cervical cancer. study design: the proposed study is an investigator initiated, single center, prospective pilotstudy. study population: 20 patients with histological proven cervical cancer stage ib1, ib2, iia of iib will be included. primary study parameters/outcome of the study: optimized t2w ultra high field (7t) mri sequences of the (para)cervical area which allow qualitative assessment of the loco-regional invasion of cervical cancer.

see brief summary

Eligibility criteria:
inclusion criteria: * histologically proven primary malignancy of the cervix uteri; * figo stage ib1, ib2, iia or iib; * ≥18 years; * written inform consent provided. exclusion criteria: * contra-indications for mri: any non-removable electronic or ferromagnetic object present in the body; pregnancy; severe claustrophobia; unable to lie still and completely horizontal for minimally 45 minutes; * body weight \>150kg; * any type of neo-adjuvant chemo- and/or radiotherapy for cervical cancer; * uterine prolapse with c ≥ -6 cm (pop-q).

Keywords: locoregional invasion stage ib1, ib2, iia or iib
vestibular schwannoma and psychological factors

Conditions: Vestibular Schwannoma

Summary: the surgery of a vestibular schwannoma induces balance disorders which have a an impact on the patient's daily life and disrupt their quality of life. but the balance disorders don't seem to be the only ones factors that impaired the patient's quality of life. it has been alrealdy shown that emotional and psychological factors are also related to patient's quality of life. this study evaluates the relationship between the balance control compensation and these factors (i.e. emotional and psychological) in the vestibular schwannoma resection process.

the research protocol is based on 5 evaluation: 3 days before surgery, 8 days, 30 days, 90 days and 360 days after surgery including posturographic tests, videonystagmography and psychological questionnaires at each evaluation.

Eligibility criteria:
inclusion criteria: * patients with unilateral vestibular schwannoma (stage i to iv according to the koos classification) with an indication for surgery. * age between 18 and 75 years * patients with written informed consent * patients with social security affiliation exclusion criteria: * patients with psychiatrics pathologies * ear pathology different from vestibular schwannoma (cholesteatoma of the middle ear, tympanic membrane perforation)

Keywords: vestibular schwannoma balance psychological factors
mri study - chronic progressive external ophthalmoplegia

Conditions: Chronic Progressive External Ophthalmoplegia

Summary: the purpose of this study is to investigate the fraction of fat on a mri scan of lower bag muscles, thighs and calves in patients with the mitochondrial disease chronic progressive external ophthalmoplegia (cpeo). additionally an investigation of the volume of the eye muscles will be done and compared to the patient's clinical presentation of ptosis and ophthalmoplegia.

the lack of energy and fatigue seen in patients with mitochondrial diseases have been assumed to be caused by an energy defect because of a genetic defect in the mitochondrial dna. the investigators have analyzed a few mri scans of muscles from patients with cpeo and have seen an extended amount of fat in their muscles, which seems to progress with age. the patient's symptoms might be caused by the extended amount of fat and thereby a less amount of active muscle instead of the "energy defect". this will be investigated in a group of patients with cpeo and the results will be compared with results from a group of healthy controls.

Eligibility criteria:
inclusion criteria: * danish patients with verified single large-scale mtdna deletions and chronic progressive external ophthalmoplegia. exclusion criteria: * patients who have metal implants in the body, for instance surgical clips, cochlear implant, pacemaker etc. * patients who are pregnant or breast-feeding. * patients who are claustrophobic
efficacy and safety of cocktail of ropivacaine for local infiltration analgesia in patients undergoing laparoscopic cholecystectomy

Conditions: Cholecystectomy, Laparoscopic; Ambulatory Surgical Procedures; Multimodal Analgesia

Summary: the goal of this clinical trial is to learn if the use of cocktail of ropivacaine,sodium bicarbonate and dexamethasone for incision local infiltration analgesia in patients undergoing ambulatory laparoscopic cholecystectomy is safe and effective. the main questions it aims to answer are: does the cocktail lower the the incidence of moderate to severe pain during movement stages within six hours after surgery. researchers will compare the cocktail to ropivacaine for incision local infiltration analgesia to see if the cocktail works to moderate the postoperative pain of ambulatory laparoscopic cholecystectomy patients. participants will: receive the cocktail or ropivacaine for incision local infiltration analgesia at the end of the surgery. answer the questions about postsurgical pain at rest or during motion(using a numeric rating scale (nrs) of 0 to 10. pain measurements were performed at 2, 6, 12, 24 hours,3,7,30 days and 3 months postoperatively.


Eligibility criteria:
inclusion criteria: * patients undergoing daytime laparoscopic cholecystectomy in sichuan provincial people's hospital ② age: 18-70 years * american society of anesthesiologists physical status classification system i-ii ④ 18 kg/㎡≤ bmi ≤ 30 kg/㎡ ⑤ no communication barriers, able to understand the research process and the use of pain scale. * signed informed consent exclusion criteria: * drug allergy related to this study * history of chronic pain, long-term use of analgesic drugs (equivalent to ≥ 10mg oxycodone per day), alcohol abuse, gastrointestinal bleeding or perforation after application of non steroidal anti-inflammatory drugs * patients with ischemic heart disease, peripheral arterial vascular or cerebrovascular disease, or patients with pulmonary heart disease, active peptic ulcer or gastrointestinal bleeding, or patients with inflammatory bowel disease * patients taking monoamine oxidase inhibitors or within 2 weeks after discontinuation ⑤ preoperative pain score (nrs ) was greater than or equal to 4 points ⑥ participated in other clinical studies within three months
search allelic imbalance of expression of brca genes in hereditary risk of breast and/or ovarian cancer

Conditions: Hereditary Breast and Ovarian Cancer Syndrome

Summary: the purpose of this study is to determine proportion of patients presented a search allelic imbalance of expression of genes brca 1 and 2 in population with hereditary breast and/or ovarian cancer risk and negative for deletion mutation brca 1 and 2 genes


Eligibility criteria:
inclusion criteria: for patients * women with breast cancer and / or ovarian cancer meet criteria suggestive of a hereditary predisposition * deleterious mutation of brca1 and brca2 sought and not highlighted * age ≥ 18 years * agreeing to participate in the study (a collection of signed informed consent) for control population * women with no history of breast and / or ovarian cancer and no family history of breast and / or ovarian cancer among family members on the 1st and 2nd degree before age 50 for breast cancer and before 60 years for ovarian cancer * agreeing to participate in the study (a collection of signed informed consent) exclusion criteria: for patients: * patients with a known deleterious mutation in brca1 and brca2 * patients do not meet criteria suggestive of a hereditary predisposition * persons deprived of liberty or under guardianship (including guardianship) for control population: * males * personal or family history of breast and / or ovarian cancer (breast or ovarian cancer in their family experienced 1st and 2nd degree before age 50 for breast cancer before age 60 for cancer ovarian) * persons deprived of liberty or under guardianship (including guardianship)

Keywords: breast cancer ovarian cancer brca 1 and brca 2
augmentation of facial wall in defective fresh extraction site for immediate implant placement

Conditions: The Augmentation of Labial Defective Wall in Fresh Extraction Socket

Summary: the study is performed to clinically and radiographically assess the efficacy of using enriched bone graft combined with slowly resorbable membrane on bone quality in immediate implant placement in extraction socket in cases with localized facial bone defect.

the study is include twelve participants , and the patients are in rolled in two groups, group one receive implant, sticky bone and laminar bone membrane . group two receive implant, sticky bone and pericardium membrane using vestibular incision and 6 months post operative radiographically assessment is performed to measure labial bone quantity formed .

Eligibility criteria:
inclusion criteria: * patient with a single hopeless tooth in maxillary anterior region. * sufficient bone apically and palatally * presence of natural contralateral tooth for the tooth being replaced * systemic healthy patients exclusion criteria: * extraction socket type iii * acute infection in hopeless tooth * a heavy smoker patient * pregnant * had received chemotherapy or radiotherapy in previous year

Keywords: labial bone augmentation, immediate implant placement . laminar bone membrane effect pericardium membrane effect
foxo3a and pu.1 in acute lymphoblastic leukemia

Conditions: Acute Lymphoblastic Leukemia

Summary: acute lymphoblastic leukemia (all) is one of the four major types of leukemia which is common in both children and adolescents; however, it is the most common pediatric malignancy diagnosed in children younger than 20 years .the disease pathogenesis results from blockade at any stages of normal lymphoid differentiation with uncontrolled proliferation of lymphoid cells. according to the world health organization (who) definition, all is categorized in b-lymphoblastic leukemia (b-all) and t-lymphoblastic leukemia (t-all), originated from b- and t-lineage lymphoid precursor cells, respectively.

proto-oncogenes and tumor suppressor genes are the most important genes involved in leukemogenesis , which their alterations disrupt normal regulatory processes such as self-renewal, proliferation, differentiation and apoptosis in target cells. among those genes foxo3a gene and pu.1 gene. foxo(fork head box ,class o) transcription factors function as a tumor suppressor gene and are important for stem cell maintenance.they are key regulators of the cellular differentiation, growth, survival, cell cycle, metabolism, and cellular stress. there are four members of the foxo transcription factors in humans : foxo1, foxo3a, foxo4, foxo6 .foxo3a is expressed in various tissues including b - and t-lymphoid cells. over expression of foxo3a in b and t cell lines induces cell cycle arrest in g1 phase , so it inhibits cell proliferation . foxo3a is an important target of pi3k/akt signaling pathway,which is hyperactivated in various types of cancers .hyperactivation of this pathway in leukemia leads to inactivation of foxo3a in leukemic cells and enhances tumor growth . pu .1(purine-rich box 1) is a member of the e26 transformation-specific (ets) family . normal hematopoiesis is securely controlled by asmall number of lineage-specific transcription factors, so that the disturbed expression or function of this group may be involved in the development of leukemia . pu.1 plays an important role in hematopiotic stem cell (hsc) self renewal and in myeloid and b-lymphoid differentiation. it controls the expression of several genes involved in hematopoiesis.

Eligibility criteria:
inclusion criteria: * children aged 2-17 years and diagnosed as new cases of acute lymphoblastic leukemia exclusion criteria: 1. age more than 17 years 2. presence of other hematological disorders, history of other malignancies ,or relapsed all 3. patients under chemotherapy or radiotherapy
short post-operative antibacterial therapy in complicated appendicitis: oral versus intravenous

Conditions: Acute Appendicitis; Acute Appendicitis With Rupture; Acute Appendicitis Without Peritonitis; Acute Appendicitis With Appendix Abscess; Appendicitis; Perforation; Appendicitis Perforated; Appendicitis Acute

Summary: short post-operative antibacterial therapy in complicated appendicitis: oral versus intravenous is a prospective randomized controlled trial comparing 24 hour intravenous antibacterial therapy to 24 hour oral antibacterial therapy after surgery in complicated appendicitis.


Eligibility criteria:
inclusion criteria: patients diagnosed with acute appendicitis and are candidates for laparoscopic appendectomy. exclusion criteria: patients with compromised immune system (hiv, diabetes), ongoing or completed radio-chemotherapy in past 5 years, prosthetic heart valve, vascular prosthesis, pregnancy.
patient satisfaction with timolol in subjects with open-angle glaucoma or ocular hypertension

Conditions: Glaucoma, Open Angle; Ocular Hypertension

Summary: this study compares patient symptoms and anterior segment safety in patients treated with timolol hemihydrate, generic timolol gel forming solution or timolol maleate.


Eligibility criteria:
inclusion criteria: * willing to comply with investigator's and protocol's instructions * patients signature on the informed consent document * primary open-angle glaucoma, pigment dispersion or exfoliation glaucoma, or ocular hypertension in at least one eye * at screening intraocular pressure must be considered to be safe, in both eyes * in non-qualifying eyes the intraocular pressure should be able to be controlled safely on no pharmacologic therapy or on study medicine alone * currently treated with one glaucoma medication, untreated intraocular pressure of less than or equal to 28 mm hg at visit 2 in both eyes exclusion criteria: * any abnormality preventing reliable applanation tonometry in either eye * any opacity or subject uncooperativeness that restricts adequate examination of the ocular fundus or anterior chamber in either eye * any concurrent infectious/noninfectious conjunctivitis, keratitis or uveitis in either eye * any history of allergic hypersensitivity or poor tolerance to any components of the preparations used in this trial * females of childbearing potential not using reliable means of birth control * pregnant or lactating females * any clinically significant, serious, or severe medical or psychiatric condition * participation (or current participation) in any investigational drug or device trial within 30 days prior to visit 1 * severe prior visual acuity or field loss from any cause * inability to understand the trial procedures, and thus inability to give informed consent * progressive retinal or optic nerve disease apart from glaucoma * serious systemic or ocular disease * intraocular laser surgery within the past three months or corneal or intraocular conventional surgery within the past 6 months * concurrent use of systemic corticosteroids, by iv, oral, dermal or topical ophthalmic route. * subjects requiring tear replacement drops or allergy medications with sympathomimetics 24 hours prior to a scheduled study visit * contraindication to beta-blocker usage including: reactive airway disease, uncontrolled heart failure, or second as well as third degree cardiac block, myasthenia gravis * any subject the investigator believes will be at risk for glaucomatous progression by their participation in this trial
retrospective review a comprehensive case database of holep procedure performed by a single surgeon

Conditions: Lower Urinary Tract Symptoms; Benign Prostatic Hyperplasia

Summary: persistent detrusor overactivity (do) after transurethral prostatectomy results in symptomatic failure in more than one third of the patients. storage symptoms are major complaints in the early postoperative period after holmium laser enucleation of the prostate (holep). to investigate the effect of do in the patients with benign prostatic obstruction (bpo), the investigators evaluated the changes in the storage symptoms following holep in conjunction with the prescription of the anticholinergic drugs.

eighty men with urodynamically proven bpo underwent holep at our hospital. all patients were evaluated preoperatively with international prostate symptom score (ipss), international continence society male questionnaire short form (ics-sf), 3-day frequency - volume charts (fvc), transrectal ultrasonography, and uroflowmetry with postvoid residual urine volume. the patients were divided into two groups; bpo without do (non-do group) and bpo with do (do group). we assessed the patients postoperatively at 2 weeks, 1, 3 and 6 months after surgery.

Eligibility criteria:
inclusion criteria: * 50 yrs or greater * international prostatic symptom score \>= 12 * bladder outlet obstruction confirmed by pressure-flow study (booi \> 20) exclusion criteria: * patients with urologic malignancies such as prostate cancer and bladder cancer * patients underwent urethral, prostate surgery * patients with urethral stricture or bladder diverticulum or bladder neck contracture

Keywords: holmium laser enucleation of prostate
the effect of progressive relaxation exercises on sleep quality

Conditions: Sleep Disturbance; Nursing Care

Summary: this study; in order to investigate the effect of progressive relaxation exercises on sleep quality, serotonin and melatonin levels in cardiac patients with sleep problems, a pretest/posttest experimental design study will be conducted with a control group. the data of this study will be collected between may 2022 and december 2022. the research will be carried out with a total of 60 (experimental group=30, control group=30) patients treated for heart failure, myocardial infarction and angina pectoris in the cardiology clinic of a university hospital. the data of the study will be collected using the richard's campbell sleep scale and the commercial elisa kit. progressive relaxation exercises will be applied to the patients included in the experimental group for 3 consecutive days. before relaxation exercises, urine melatonin, serotonin level \[5-hydroxyindolacetic acid (5-hiaa) and 6-sulphatoxymelatonin(6-hms)\] measurement and sleep quality will be measured according to the kit procedure. in the analysis of the data, significance p \<0.05 will be accepted. institutional permission, ethics committee approval, and written consent from the participants were obtained before the study.

the data of this study will be collected between may 2022 and december 2022. the research will be carried out with a total of 60 (experimental group=30, control group=30) patients treated for heart failure, myocardial infarction and angina pectoris in the cardiology clinic of a university hospital. the study was planned as a randomized controlled experiment. patients meeting the research criteria will be randomly assigned to 30 experimental-30 control groups by randomization method. information form, richard's campbell sleep scale and commercial elisa kit will be used as data collection tools in the research.

Eligibility criteria:
inclusion criteria: * older than 18 years of age, * who reported sleep problems * scored 25 or less on the richard's campbell sleep scale, * were scheduled to be hospitalized for at least 4 days, * had no pain, were able to give urine samples, * were lying in a single or double room, * had serotonin-containing or decreased serotonin secretion. * do not take any medication that provides medical treatment, * can do pge, * do not have a hearing problem or a communication disability will be admitted. exclusion criteria: * who were discharged early, * had an unexpected change in their condition, * started to experience pain, * could not adapt to the working principles, * gave up volunteering will be excluded from the study.

Keywords: sleep quality progressive relaxation exercises melatonin serotonin