Kornimate/medical-research-clean huggingface dataset:
clinical investigation to evaluate the suitability of strokewave in distinguishing haemorragic from ischaemic strokes

Conditions: Stroke, Ischemic; Stroke Hemorrhagic

Summary: this is a pilot, monocentric clinical investigation to evaluate the suitability of strokewave in distinguishing haemorragic from ischaemic strokes. the strokewave is a microwave device which employs a novel technique to generate images by processing very low power (\<1mw) microwaves. the trial design has been developed in order not to interfere with thw standard diagnostic approach used for the hyperacute stroke patients, nor to modify the usual standard timing of the routine assessment.

the number of participants will be 60. patients with hyperacute stroke (within 4 hours from the onset) or with awake or unknow time of onset strokes will be enrolled in the study. all patients will be registered at emergency room of hospital, and according to the internal procedure will be clinically evaluated by the neurologist of the stroke team. nihss and mrs will be administered and scores registered. the scanning with strokewave will be performed in 5 minutes, after ncct and before the cta acquisition, in the ct room. strokewave will be placed on the head of the patients in the ct room passing toward the gantry of the ct avoiding any loose of time. after the strokewave scanning, the system will be removed. the data collected will be processed through an imaging algorithm which is integrated in the device. the final output will be composed by one or more images, plus one or more parameters describing the images.

Eligibility criteria:
inclusion criteria: * adult \> 18 years old * patients with hyperacute stroke, i.e. which are referred to the emergency room with a 'stroke code' exclusion criteria: * mrs \>3 before the stroke onset * life expectancy \<3 months * gcs=3
evaluation of the safety and outcomes of outpatient management with mild to moderate covid-19 pneumonia

Conditions: Covid19; Pneumonia

Summary: the purpose of this study is to evaluate the strategy of investigators for outpatients sars-cov-2 moderate pneumonia management in terms of efficacy and patient safety. the investigators ultimate goal is to validate first wave management strategy in order to support the investigators future approach in the event of a second wave, and spare the hospital resources by safely keeping at home as many patients as possible.

the investigators focused on participants consulting in the emergency department at the hug who remained in an outpatient setting, with pneumonia and moderate illness, defined by individuals who have evidence of lower respiratory disease by clinical assessment or imaging and a saturation of oxygen (sao2) \>93% on room air and no other hospitalization criteria (curb 65 score below 2points). for patients' follow-up, the investigators have created an aftercare ambulatory unit, open 5/7 days. the investigators were able to conduct 64 consultations between april 2 and may 5, 2020. every participant had suspected or confirmed sars-cov-2 pulmonary tract infection. the follow-up data was entered into dpi (patient's medical record at hug) on a specific consultation form. patients followed in the investigators consultation were contacted between 30 and 60 days after diagnosis by the covicare team. the covicare team is call-center composed of medical students and primary care physicians who remotely followed patients with covid-19 by calling them by phone or telemedicine every day or every other day depending on patients' needs and health status. the investigators will export data from redcap concerning post-hospitalization, satisfaction survey on our care and oral consent for use of data (argos study ccer number 2020-01273).

Eligibility criteria:
inclusion criteria: * all persons with suspected or confirmed sars-cov-2 pneumonia who consulted in the emergency department of the hug without criteria for hospitalization4 (pneumonia with curb-65 \>= 2 or new o2 dependency or increased o2 requirements or sustained respiratory rate≥20 min or decompensated comorbidity or major alteration of the general state) and who have been scheduled for outpatient follow-up in hug. exclusion criteria: * patients with hospitalization criteria * refusal to consent documentation found in the computerized patient record or oral refusal consent during follow up call.
accuracy characterization study

Conditions: Type2 Diabetes; Type1diabetes; Insulin Dependent Diabetes

Summary: to demonstrate point accuracy of the abbott sensor based glucose monitoring system (system) interstitial glucose results against venous glucose reference and capillary fingerstick using the consensus error grid over the wear duration. during the course of the wear duration, the subject is required to be testing fingerstick glucose measurement at least 8 times a day for capillary reference glucose measurements and three in-clinic visits of maximum 10 hours each for venous reference glucose measurements. with every reference measurement, the subject or study staff will perform a measurement on the system.


Eligibility criteria:
inclusion criteria: 1. subject must be at least 18 years of age. 2. subject must have type 1 or type 2 diabetes for at least 2 years prior to enrollment. 3. subject must require insulin therapy through an insulin pump and/or multiple daily insulin injections (at least 3 injections daily) for at least 6 months prior to enrollment. 4. subject must be able to read and understand english. 5. in the investigator's opinion, the subject must be able to follow the instructions provided to him/her by the study site and perform all study tasks as specified by the protocol. 6. subject must be available to participate in all study visits up to a period of 14 days. 7. subject must be willing and able to provide written signed and dated informed consent. exclusion criteria: 1. subject has known allergy to medical grade adhesive or isopropyl alcohol used to disinfect skin. 2. subject is pregnant, attempting to conceive or not willing and able to practice birth control during the study duration. 3. subject has skin lesions, scarring, redness, infection or edema at the application sites that could interfere with device placement or the accuracy of interstitial glucose measurements. 4. subject currently is participating in another clinical trial. 5. subject has donated blood within 112 days prior to the beginning of the study activities. 6. subject has concomitant medical condition which, in the opinion of the investigator, could interfere with the study or present a risk to the safety or welfare of the subject or study staff. such conditions include but are not limited to: * history of hiv, hepatitis b or c, or other blood-borne pathogen; * subject has an increased risk of bleeding. * subject has x-ray, mri or ct appointment scheduled during the period of study participation, and the appointment cannot be rescheduled for a time before study participation starts or after study participation ends. * subject is unsuitable for participation due to any other cause as determined by the investigator.
the effect of tennis ball on balance and quality of life in cancer patients with neuropathy.

Conditions: Cancer; Neuropathy; Therapy-Associated Cancer

Summary: this research; it was aimed to evaluate the effect of myofascial release using a tennis ball on balance and quality of life in cancer patients who developed peripheral neuropathy.


Eligibility criteria:
inclusion criteria: * complaints of peripheral neuropathy among patients who have completed the standard chemotherapy treatment protocol due to colorectal cancer, entered the follow-up process and come to the outpatient clinic for routine control. * registered to selçuk university faculty of medicine hospital medical oncology polyclinic * karnofsky performance scale must be 80 or above * over 25 years old, under 65 years old * presence of grade 2 or higher peripheral neuropathy, * being conscious and cooperative * verbal and written approval to participate in the study after an explanation about the study is made. exclusion criteria: * having any skin sensitivity on hands and feet before * refused to participate in the study after making a statement about the study * development of peripheral neuropathy due to reasons other than chemotherapy \[tumor compression, nutritional disorders, infections or major systemic disease (diabetes mellitus, etc.)\] * bone or spine metastases

Keywords: cancer pain neuropathy pain tenis ball myofascial release
antiperspirant in the treatment of residual limp hyperhidrosis for prosthetic users

Conditions: Hyperhidrosis; Residual Limbs

Summary: the aim of the present pilot study is to evaluate the effect of antiperspirant to treat residual limb hyperhidrosis with the emphasis on the utility of the iodine-starch test to identify the location of the sweating.

many persons with lower limb amputation report that they have major problems with sweating (hyperhidrosis) on the stump in connection with prosthetic use. despite the frequency and the negative effect of sweating for prosthetic users, there is a lack of evidence on how the sweating should be examined and treated. in the dermatological literature, the guidelines recommend the use of topical antiperspirants such as aluminum chloride as first-line treatment. no studies have previously been published evaluating the effect of antiperspirant on prosthetic users.

Eligibility criteria:
inclusion criteria: 1. over 18 years, 2. used a prosthetic for at least 1 year, 3. hdss score of ≥ 2, 4. use the prosthetic daily and be able to walk for a minimum of 10 minutes. exclusion criteria: 1. open wounds on the stump, 2. known sensitivity or allergy to iodine and/or starch, 3. known sensitivity to antiperspirant.

Keywords: lower limb amputation hyperhidrosis prosthetic users aluminum chloride sweating
safety and tolerability study in patients with mild to moderate alzheimer's disease (ad)

Conditions: Alzheimer's Disease

Summary: this study will evaluate the safety and tolerability and aß-specific antibody response of cad106 in patients with mild to moderate alzheimer's disease. patients also had a 2 year follow-up to assess disease progression where no drug was administered.


Eligibility criteria:
inclusion criteria: * males and/or females patients between 50 to 80 years of age (both inclusive). * female patients must be without childbearing potential (post-menopausal or surgically sterilized). * diagnosis of dementia of the alzheimer's type according to the dsm-iv criteria (diagnostic and statistical manual of mental disorders, 4th edition). * mild to moderate ad as confirmed by mini-mental state exam score of 16 to 26 (both inclusive) at screening. * able to provide written informed consent and having a responsible caregiver that can provide written assent prior to study participation. for patients who have been declared mentally incompetent, a legal representative will need to provide informed consent on their behalf. exclusion criteria: * previously participated in an ad vaccine study and received active treatment * history or presence of an active autoimmune and/or cerebrovascular disease * history or presence of seizures, with an acute or chronic inflammation * clinically relevant atopic condition, who suffer from an other neurodegenerative disease and/or psychiatric disorders (with the exception of successfully treated depression) * immunosuppressive treatment including systemic steroids * obtained a vaccination (e.g. against influenza) within 4 weeks before the first study drug injection * advanced, severe, progressive or unstable disease that might interfere with the safety of the patient * started treatment with psychotropic medication within 3 months (4 weeks for ssris and other newer antidepressants without anticholinergic properties) prior to randomization with the exception of mild hypnotic drugs (e.g. zolpidem, zopiclone, oxazepam) and low doses of neuroleptic drugs (e.g. up to 2 mg risperidone). patients, who are on stable treatment with cholinesterase-inhibitors (cheis) and/or memantine for at least 3 months, and/or with ssris and/or other newer antidepressants (without anticholinergic properties) for at least 4 weeks before randomization, can be included into the study.

Keywords: mild, moderate alzheimer's disease (ad), aß-specific antibody, cad106
the effects of linezolid and vancomycin on inflammation and cellular signaling vents

Conditions: Sepsis

Summary: we will determine if linezolid inhibits cellular activation and production of pro-inflammatory cytokines, providing mechanistic rationale for its clinical efficacy and the justification for further investigations in s. aureus sepsis.


Eligibility criteria:
inclusion criteria: * healthy, taking no medications, and not recently hospitalized exclusion criteria: * infection (active)
electronic warning systems in diagnosis and treatment of aki

Conditions: Acute Kidney Injury

Summary: to set up electronic early warning system of aki patients; to develop aki's intervention, the follow-up process, and the renal physician is responsible for the implementation. to observe the method after implementing the treatment efficacy of aki and the differences between the traditional treatment process.

to set up electronic early warning system according to kdigo aki diagnosis standard, real-time monitoring of hospitalized patients with renal function data, real-time detection of aki patients, notify the diagnosis of renal physician; to develop aki's intervention, the follow-up process, and the renal physician is responsible for the implementation. to observe the method after implementing the treatment efficacy of aki and the differences between the traditional treatment process.

Eligibility criteria:
inclusion criteria: eligible participants were adults aged 18 years or older who were in hospital with stage 1 or greater acute kidney injury as defined by kidney disease improving global outcomes creatinine-based criteria. exclusion criteria: exclusion criteria were initial hospital creatinine 4•0 mg/dl (to convert to μmol/l, multiply by 88•4) or greater, fewer than two creatinine values measured, inability to determine the covering provider, admission to hospice or the observation unit, previous randomisation, or end-stage renal disease.

Keywords: acute kidney injury electronic alerts
safety and efficacy of long-term somatropin treatment in adults

Conditions: Growth Hormone Disorder; Adult Growth Hormone Deficiency

Summary: this study is conducted in europe. the aim of the study is to evaluate safety and efficacy in adults treated with somatropin (norditropin®).


Eligibility criteria:
inclusion criteria: * in need of somatropin or current user
acupuncture in a multidisciplinary approach for vulvodynia and chronic pelvic pain

Conditions: Vulvodynia; Chronic Pelvic Pain

Summary: background: vulvodynia and chronic pelvic pain (cpp) are common and challenging gynecologic pain syndromes. a multidisciplinary approach is recommended. study aim: to study the effectiveness of acupuncture as part of a multimodal treatment for women with vulvodynia and cpp. design: randomised controlled clinical study study population: recruitment from a university outpatient clinic study groups: participants will be randomised (1:1) * acupuncture group * waiting list control group sample size: 68 patients study outcome * subjective pain perception (vas) * health-related quality of life (questionnaires)


Eligibility criteria:
inclusion criteria: * women with vulvodynia and/or chronic pelvic pain of at least 6 months duration * multidisciplinary treatment for at least 3 months exclusion criteria: * pregnancy * current malignancy * major neurologic or psychiatric morbidity * study participation in lydia trial (lasertherapy for vulvodynia)

Keywords: acupuncture
obesity-related genes in taiwanese undergoing weight loss

Conditions: Morbid Obesity

Summary: to investigate: 1. associations between mirna and insulin signaling-related gene expressions in abdominal adipose tissues in obese subjects. 2. differences in mirnas expressed by intrabdominal omental adipose tissues between genders.

compared the differences in microrna expressions of abdominal adipose tissue in morbid obese male and female subjects to elucidate the possible regulatory role of microrna in insulin signaling-related gene expression levels and its association with biochemical markers. we hope to find a mirna that can be used to predict the syndrome associated with obesity.

Eligibility criteria:
inclusion criteria: * morbid obesity,bmis\> 40 kg/m2 * subjects who underwent bariatric surgery exclusion criteria: * obese subjects with complicated metabolic disorders * thyroid disease

Keywords: abdominal adipose tissue; microrna
the peanut ball use on labor

Conditions: Birth Outcome, Adverse; Birth, First; Labor Long; Apgar; 4-7 at 1 Minute

Summary: the purpose of this study was to evaluate the effect of using peanut balls during labor on labor memory, labor satisfaction, labor length, and neonatal apgar scores.

the purpose of this study was to evaluate the effect of using peanut balls during labor on labor memory, labor satisfaction, labor length, and neonatal apgar scores. this randomized, controlled, single-blind trial was conducted in 156 primiparous pregnant women (peanut ball group n=78, control group n=78) who delivered between march 2024 and october 2024. pregnant women in the peanut ball group were instructed to perform movements with the peanut ball after cervical dilation reached 4 cm. the control group received only standard intrapartum midwifery care. data were collected by personal information form, labor and postpartum follow-up form (apgar score, etc.), birth memory and recall scale 4 hours after delivery, and birth satisfaction scales.

Eligibility criteria:
inclusion criteria: pregnant women were included if they had indications for vaginal delivery, * were primiparous, * had cervical dilation of 3 cm or more, * had term pregnancy (38 to 42 weeks of gestation), * had a single, * healthy, * vertex-positioned fetus, * had no complications that could cause dystocia during labor (contraction anomalies, birth object, dystocia related to the birth canal, dystocia related to the mother's psyche, dystocia related to the mother's psychology), * did not use analgesia and anesthesia during the first stage of labor, * i did not have any physical disability to take the positions to be used in the study, * did not have any communication problems, * had language skills sufficient to speak and understand turkish. exclusion criteria: * pregnant women were excluded if they had abnormal changes in fetal heart rate during labor (fetal distress, etc.), * had an unexpected pregnancy or fetal complication, * had a high-risk pregnancy, * were taking magnesium sulfate, * had symptoms of intrauterine infection, * had previously attended antenatal classes, * or reported having been educated about birthing balls.

Keywords: birth memory and recall birth satisfaction labor length apgar score peanut ball
comparing myopia control efficacy in children with 4 methods: orthokeratology, dims, disk, and svs.

Conditions: Myopia

Summary: the goal of this clinical trial is to learn if 3 optical interventions（dims, disc and orthokeratology) to control myopia have different efficacy to slow myopia progression in children when the control is single focus spectacles(svs). it will also learn about the safety of all 4 interventions. the main questions it aims to answer are: does orthokeratology slows the progressing myopia more significant than the dims or disk? what medical problems do participants have when taking orthokeratology, dims and disk? researchers will compare all the 3 interventions to a placebo (svs) to see if 3 interventions has significant difference in slow the axial length elongation as well as the refraction changes. participants will: take orthokeratology, dims, disk or svs every day for 12 months visit the clinic once every 3 months for checkups and tests.

orthokeratology and disk are contact lenses, while dims and svs are spectacles.

Eligibility criteria:
inclusion criteria: * must agree to participate in the study * must have cycloplegic refraction with spherical equivalent refractive (ser) * - 2.00 d \~ - 5.00 d (including the boundary values) * clinical diagnosis of astigmatism was ≤ 1.00d * must be able to have corrected visual acuity ≤ 0.00 logmar of either eye * must be able to wear either of svs/dims/disc/orthokeratology lenses and kept the same intervention for 12 month * must have the front cornea curve value between 41.00d\~44.00d * must have axial length of the study eye between 23.00mm and 25.00mm at baseline exclusion criteria: * dry eye * keratitis * conjunctivitis * clinical diagnosis of entropion * clinical diagnosis of glaucoma * clinical diagnosis of retinal lesions * clinical diagnosis of amblyopia * clinical diagnosis of optic media lesions (e.g., central thick corneal scars, cataract) * clinical diagnosis of optic nerve dysfunction * have medical history of atropine eyedrops (including 1% high concentration , 0.05%, 0.01% or other low concentration) * have history of wearing peripheral defocus spectacles * have history of wearing duo-focal soft contact lenses * unable to follow up * investigators consider to be not eligible.

Keywords: myopia children
molecular analysis for gastro-esophageal cancer: multicenter discrete choice experiment

Conditions: Esophageal Cancer; Gastric Cancer

Summary: the goal of this survey is to investigate the participants' preference for a specific screening/diagnostic tool to detect and assess gastro-esophageal cancer. the main question it aims to answer are: * which diagnostic modality is preferred by patients and the general population? * which features of the diagnostic test are most detrimental in the decision-making for one or the other modality? * are geographical differences present in regard to the preference for a diagnostic modality? participants will be asked to complete a survey of 20-25min, including a brief intake regarding their socio-economic status. this approach will allow us to correct for confounding factors.


Eligibility criteria:
inclusion criteria: 1. individuals \>18yo to 75yo (upper age limit of barrett's surveillance) 2. access to computer or smartphone 3. clear understanding of available languages of the experiment (english, french, dutch, spanish, german, chinese, japanese) exclusion criteria: 1. individuals less than 18yo and more than 75yo 2. incarcerated individuals

Keywords: esophageal cancer survey gastric cancer