Kornimate/medical-research-clean huggingface dataset:
evaluation of new histoprognostic criteria in a retrospective study of colon cancers operated at amiens university hospital

Conditions: Colonic Neoplasms

Summary: colon cancer is a very common cancer. prognosis and adjuvant treatment depend on the pathological results. histoprognostic new factors have recently been published by several authors, but their validity is still debated.


Eligibility criteria:
inclusion criteria: * all patients operated on for colon adenocarcinoma between 2004 and 2009 at the university hospital of amiens exclusion criteria: * non-operated patients * patients operated on before 2004 or after 2009 * patients operated in another center * the other histological types * vicinity of tumors invading the colon by contiguity * colic metastasis * patients whose blocks or blades were not found in the archives.
endothelial and metabolic effects of glucagon-like peptide-1 (glp-1) in coronary circulation in patients with type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: glp-1 is an incretin hormone which is discharged from the intestines after food intake. the hormone is known for its powerful insulinotropic and trophic effects on the beta cells in the pancreas and is currently used as an anti-diabetic agent in patients with type 2 diabetes (t2dm). glp-1 receptors are widely distributed including on the endothelial cells in both coronary and skeletal muscle circulation and on the myocardium. glp-1-receptor studies on knock-out mice have shown that they exhibit a reduced myocardial contractility and reduced diastolic heart function. glp-1 also shows beneficial cardiovascular effects in patients with acute myocardial infarctions and dogs with dilated cardiomyopathy in that the left ventricle function and endothelial dysfunction improves after glp-1 treatment via insulin-independent mechanisms. preclinical studies indicate that exogenous administrated glp-1 in physiological concentrations can improve perfusion but this has never been tested in humans. it is also unknown whether glp-1 can directly increase the glucose/metabolite uptake across both cardiac and skeletal muscle in an insulin independent manner. unpublished studies do however indicate that the improvement in the cardiovascular system is largely dependent upon a high blood glucose level and only partially dependent upon the antiglycemic effects of glp-1. in the proposed studies the investigators wish to examine the physiological role of glp-1 receptor stimulation both with regard to perfusion, metabolic improvement as well as cardiac inotropic. these studies will be conducted in both healthy and in t2dm patients.


Eligibility criteria:
inclusion criteria: * caucasians over 18 * emitted for non-acute coronary arteriography (cag) in gentofte hospital * bmi 23-35 kg/m2 * normal hemoglobin * who gives informed consent * those with type 2 diabetes: hba1c 6-10% * those without type 2 diabetes: normal oral glucose tolerance test (ogtt) according to who criteria exclusion criteria: * liver disease (alat \> 2x normal) * diabetic nefropati (creatinine \> 130 µm or albuminuria) * treatment with medicine that cannot be paused 12 hours before intervention * pregnancy or breastfeeding * insulin- or glitazone treatment * healthy controls: close family history with diabetes * unstable angina pectoris * non-stemi * atrial fibrillation * valvular disease * lvef \< 50% * severe systemic disease * type 1 diabetes

Keywords: basic science type 2 diabetes mellitus glucagon like peptid-1 coronary bloodflow metabolite uptake
an integrated optimization of surgery and radiotherapy techniques to improve cosmetic outcome and quality of life in breast conserving therapy for breast cancer patients (starlings study)

Conditions: Breast Fibrosis; Breast Cancer; Breast Cancer Female; Breast Neoplasms; Breast Carcinoma in Situ; Breast Carcinoma

Summary: to assess the role of different combinations of (oncoplastic) surgery and radiotherapy techniques as risk factors for moderate to severe fibrosis and for moderate to poor cosmetic outcome.

the primary objectives of this study are to assess the role of different combinations of (oncoplastic) surgery and radiotherapy techniques as risk factors for moderate to severe fibrosis and for moderate to poor cosmetic outcome. based on these insights predictive models for the development of moderate to severe fibrosis and moderate to poor cosmetic outcome will be developed. second, the relation between the presence and severity of fibrosis, cosmetic outcome and different qol domains and symptoms will be assessed.

Eligibility criteria:
inclusion criteria: * female patients aged ≥ 18 years * history of bct with adjuvant radiation therapy for non-metastatic, histologically proven invasive breast cancer or dcis. in light of bct adjuvant systemic treatment (i.e. endocrine therapy, chemotherapy and immune therapy) is allowed. * operated between 1st of january 2016 and 31th of december 2020 * treated according to the currently applied dose fractionation schedules, i.e. whole breast radiotherapy (22, 23), with or without boost * adequate understanding of the dutch language and written informed consent exclusion criteria: * any breast surgery or re-irradiation on the breast area after bct * progression of disease (and additional treatment) since bct * patients who received partial breast irradiation * current pregnancy or breast feeding

Keywords: fibrosis cosmetic outcome quality of life oncoplastic breast surgery radiotherapy
mirror therapy and hand rehabilitation

Conditions: Hand Fractures

Summary: objective: the purpose of this study is to determine effects of mirror therapy in restoring hand function in patients with flexor lag following orthopedic injuries. methods: in a prospective randomized controlled trial, 22 patients with flexor lag will be measured. intervention group will receive mirror therapy, 30-minute a day, 5 days a week for 3-week, as well, half an hour conventional rehabilitation after each mirror therapy session. patients in the control group will receive the same treatment program, but instead of mirror, they will directly observe the affected hand. outcome measures including total active motion (tam), and disabilities of arm, shoulder and hand (dash) questionnaire will be administered before and after the treatment period and 3 weeks after the final treatment session.


Eligibility criteria:
inclusion criteria: * hand orthopedic injuries * more active range of motion than passive range of motion exclusion criteria: * crush injuries * hand deformities * not treated fractures and tendon ruptures * complex regional pain syndrome * psychiatric problems

Keywords: hand flexor tendon injuries hand extensor tendon injuries hand joint dislocations and subluxation
prevalence of psychocognitive impairments in adolescents surviving childhood leukemia : lea-psycog

Conditions: Adolescents Surviving Childhood Leukemia LEA

Summary: the objective of the lea-psycog project is to assess the prevalence of psychiatric disorders and psychocognitive impairments in adolescents surviving childhood leukemia . the second objective is to explore the complex relationships between psycocognitive development and soiciodemodemographics data, main characteristics of leukemia, treatments, side-effects, quality of life and characteristics of proxyies environment. 3. materials and methods the lea study is based on the constitution of a multi-centric prospective cohort in 11 university hospitals: bordeaux, clermont-ferrand, grenoble, lyon, paris (trousseau, robert debré, st louis), marseille, montpellier, nancy, nice, rennes. are inclued in lea all the children diagnosed and treated for acute leukemia since january 1980 (incident and prevalent cases), surviving at month 24 for the aml and all grafted in complete remission and at month 48 for the all not grafted in first complete remission. the lea psy-cog study rests on a sample of the lea cohort. are included the patients 12-17-years-old from the paca-corse sub-cohort (administrative district of 4 million of people which corresponds to the marseille and nice centers). patients from this two centers are the patients with the more important length of survey, allowing us to produce a not biaised estimation of prevalence rate. finally, the choice of this subsample is supported by the proximity of the mediterranean center for adolescent in marseilles, specifically dedicated to the psychological follow-up of children suffering from cancer.


Eligibility criteria:
inclusion criteria: * - age 18-year-old subordinate at the time of the diagnosis; * diagnosis of acute(sharp) leukaemia; * diagnosis from january, 1980; * treatment(processing) of the acute(sharp) leukaemia introduced in one of the inquiring centers (services(departments) specialized hematology and clermont ferrand's pediatric oncology, grenoble, lyon, marseille, nancy, nancy, nice, paris - robert debré/saint debré/saint louis/trousseau louis/trousseau; * living in france; * possessing a national insurance scheme * 24-month-old survivor of recoil(drop) with regard to(compared with) the diagnosis for the leukaemia aiguës myéloblastiques (lam) and leukaemia aiguës lymphoblastiques ( lal) transplanted in 1st complete forgiveness; or in 48 months of recoil(drop) with regard to(compared with) the diagnosis for the lal not transplanted in first complete forgiveness; exclusion criteria: * failure to respect the criteria of inclusion beforehand quoted, * initial treatment(processing) realized except 2 participating centers (marseille, nice), even in case of moving in in the geographical zones covered by these centers during the phase of treatment(processing) or in the course of follow-up
a prospective observational study of tocilizumab (roactemra/actemra) in participants with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: this prospective observational study will investigate the effect of tocilizumab on fatigue in participants with moderate to severe rheumatoid arthritis who have an inadequate response to disease-modifying antirheumatic drugs or anti-tumour necrosis factor (anti-tnf) drugs. data will be collected from participants for 6 months.


Eligibility criteria:
inclusion criteria: * participants with moderate to severe ra who have been considered and proposed by the rheumatologist to start treatment with tocilizumab according to his/her clinical judgment and the conditions approved in the summary of product characteristics (spc). exclusion criteria: * participants previously or currently treated with roactemra/actemra in clinical trials * absolute neutrophil count less than or equal to (\</=) 2x10\^9 per liter (/l)
iron bioavailability of high surface area ferric phosphate

Conditions: Iron-deficiency

Summary: the primary objective of this study is to compare iron absorption of high surface area ferric phosphate with that of ferrous sulfate and bulk ferric phosphate in a rice-based meal in non-pregnant women.


Eligibility criteria:
inclusion criteria: * women of reproductive age (18 to 49 years) in thailand * bmi \< 23 kg/m2 * body weight \< 65 kg * mildly anaemic to normocythemic (hb 80-110 g/l) * ferritin \< 25 µg/l * not pregnant (confirmed by pregnancy test stripe) or lactating * no inflammation (crp \< 5 mg/l) * having provided written informed consent exclusion criteria: * haemoglobinopathies (except heterozygosity for haemoglobin e and alpha-thalassemia 1) * coeliac disease or other chronic diseases of malabsorption that could influence iron absorption or metabolism * blood donation or significant blood loss due to surgery or accident \< 4 months before start of the study * consumption of vitamin or mineral supplements 2 weeks before start of the study * regular use of medication (except oral contraceptives), that influences iron absorption * chronic inflammatory disease * smoking
functional effects of botox on the brain using mrs and fmri

Conditions: Healthy

Summary: the injection of botox into peripheral muscles has been shown to have therapeutic effects in a growing number of indications including disorders involving skeletal muscle (e.g., strabismus, blepharospasm, cervical dystonia, spasticity, cosmetic), smooth muscle (e.g., bladder), glands (axillary hyperhidrosis) and nociceptive pain (e.g. migraine) (brin. 2014). recently, several studies have suggested that peripheral botox injections in the region of the glabellar lines (muscles around the eyes) may be effective in treating major depression and chronic migraine. however, the mechanism underlying the effect of peripheral botox injections on the brain is not well understood. therefore, the investigators propose to further explore the functional effects of botox injections on brain in healthy controls. the approach will involve the measurement of brain metabolites in the brainstem using mrs as well as an investigation of the functioning and connectivity between regions of the brain using resting state mri and high resolution fmri.

participants will receive one mri scan session prior to a standardized, clinical dose of botox injected into the forehead per fda-approved procedures. participants will then undergo a second mri scan session 2-3 weeks later, after the botox has taken maximal effect. examining fmri of the brainstem and the functional connectivity of the brainstem and connections to cortex, may provide additional insight into the effects of botox on neurologic and psychiatric disorders.

Eligibility criteria:
inclusion criteria: * females * ages 30-40 years of age * right-handed * normal or corrected-to-normal vision * no history of psychiatric, neurological, or medical co-morbidities that might interfere with normal brain functioning * fluent in english * moderate to severe glabellar lines exclusion criteria: * pregnancy * ferrous metal, a pacemaker, or other battery-operated device implanted in the body * claustrophobia * known hypersensitivity to botulinum toxin * infection on the forehead or between the eyes * urinary tract infection
algorithm for predicting the unfavorable course of sepsis in children

Conditions: Sepsis

Summary: a comprehensive strategy will be used to investigate the relationship and correlation between 4 diagnostically significant markers relevant for early diagnosis and prediction of complications and death in the development of sepsis in children (c-reactive protein, procalcitonin, presepsin and lipopolysaccharide binding protein). for the first time, an attempt will be made to assess the genetic characteristics of the patient's from the point of view of predisposition to the unfavorable development of the sepsis based on the study of polymorphism of a number of genes of the immune system (tumor necrosis factor beta; interleukin 6, 8, 10; lymphotoxin alpha, etc.). based on the study results, an algorithm to predict the unfavorable course of sepsis in children will be developed using a comprehensive assessment of biochemical and molecular genetic markers.

* analyze biochemical markers and immune status data in sepsis patients and in the comparison group; * assess the state of the cellular immunity, level of pro-inflammatory cytokines, genetic polymorphism of immune response genes in sepsis patients; * carry out a correlation analysis of clinical and laboratory data and immune system among patients of different groups (with and without septic shock, taking into account the outcome); * assess the relationship between the genetic characteristics of the patient's immune system and the severity of the pathological process; * based on the data obtained, prepare instructions for use, which describes an algorithm to predict the unfavorable course of sepsis in children.

Eligibility criteria:
inclusion criteria: * age from 1 month to 18 years; * confirmed septic process$ * informed consent. exclusion criteria: * age from 18 years; * refuse of patient to participate in the trial; * chronic mental disorders with severe manifestations; * pregnancy/lactation; * intercurrent severe chronic diseases; * hiv, hepatites b/c; * active tuberculosis; * cachexia of any origin; * malignant neoplasms.

Keywords: sepsis monocytes neutrophils genetic polymorphism pdrf
acute low back pain: causes, mechanisms, treatment and followup

Conditions: Acute Low Back Pain; Physical Activity

Summary: the purpose of this study is to investigate acute low back pain, its origin, mechanisms, the cause of pain, evaluation of treatments and development. employees from a large local manufacturing company are sent for a complete orthopedic and pain evaluation immediately after onset of acute low back pain. thereafter, the included patients are allocated either to the advice to stay as active as possible in spite of the pain or to adjust their activity to the pain. pain intensity and physical activity are followed prospectively over seven days using a diary and a pedometer.

the purpose of this study is to investigate acute low back pain, its origin, mechanisms, the cause of pain, evaluation of treatments and development. employees from a large local manufacturing company are sent for a complete orthopedic and pain evaluation immediately after onset of acute low back pain. the patients go through x-ray examinations, physical examinations, they complete a battery of questionnaires covering history of acute low back pain, lifestyle characteristics, work place factors, psychosocial factors, and indicate pain intensity and pain locations. thereafter the patients are randomly allocated to one of two treatment advices: stay active as much as possible in spite of pain or adjust the activity to the pain. during seven days after the medical examination the patients wear a pedometer attached to the waist and annotate the number of steps and pain intensity, pain location and pain-related disability in a diary. a numeric graphic scale is used for pain intensity. work absenteeism and sick leave due to the current acute back pain is collected from the company records. immediate inclusion after pain onset is facilitated with continuous communication with the manufactory company. physical activity and pain development over the seven days is investigated statistically using linear mixed models for repeated measures.

Eligibility criteria:
inclusion criteria: * severe acute low back pain, duration within 24h after onset, pain exceeds 50mm on the visual analog scale (vas) exclusion criteria: * sick-leave because of low back pain or in spine in the last month
supplementation with a highly-concentrated docosahexaenoic acid (dha) triglyceride in patients with keratoconus

Conditions: Keratoconus

Summary: the goal of this randomized controlled preliminary study is to assess the effect of daily supplementation with a nutraceutical formulation of a highly-concentrated dha triglyceride plus minerals on ophthalmological parameters and biomarkers of oxidative stress and inflammation in blood samples of patients with keratoconus.the main questions it aims to answer are: * improvements in ophthalmological parameters. * increase in antioxidant capacity, decrease in inflammatory status, and changes in lipidomic biomarkers. participants are patients with keratoconus who will be given the nutraceutical supplementation for 3 months. if there is a comparison group: researchers will compare patients with keratoconus not given the nutraceutical formulation to see differences in the study variables

among omega-3 polyunsaturated fatty acids (pufas), docosahexaenoic acid (dha, c22:6-n3), a critical component of cell membrane phospholipids, exerts pleiotropic effects at both central and peripheral levels with health benefits in many aspects of neuronal, immune, cognitive, and cardiovascular functions clinical studies of dietary sup-plementation with a highly-concentrated dha triglyceride have shown consistent an-ti-inflammatory, antioxidant, antiangiogenic, and antiproliferative effects targeting pathophysiological pathways involved in different eye diseases, including diabetic retinopathy and macular edema, ocular surface disorders, meibomian gland dysfuncton, and pseudoexfoliative glaucoma. based on this experience, it was considered of interest to explore the antioxidant and anti-inflammatory potential of a highly-concentrated dha triglyceride supplement in patients with keratoconus. for this purpose, a prospective preliminary study was designed to assess the effects of 3-month dha nutritional supplementation on clinical variables, and inflammatory and oxidative stress biomarkers of patients with early and moderate keratoconus.

Eligibility criteria:
inclusion criteria: * diagnosis of keratoconus stages i to iii according to the amsler-krumeich classification * non-contact lens wearers * no history of previous corneal surgery * capacity to volunteer and willing and able to follow the study protocol exclusion criteria: * advanced keratoconus (stage iv of the amsler-krumeich classification * other ectasias (e.g. iatrogenic secondary to ocular surface surgery with excimer laser, radial keratotomy, traumatic corneal ectasia, etc.) * eyelid alterations * previous ocular surgery * any ocular or systemic condition that may affect the interpretation of results * glaucoma or ocular hypertension * history of ocular trauma, infection or inflammation * current treatment with topical or anti-inflammatory drugs * use of nutritional supplements including omega-3 fatty acids, vitamins and minerals (unless a washout period of 1 month had been established) * hypersensitivity to fish proteins * pregnant women * refusal to sign the written informed consent
a safety comparison of iopromide and iodixanol in renal impaired patients

Conditions: Kidney Failure, Chronic

Summary: the investigators intend to find out which contrast agent has less kidney toxicity in renal impaired patients undergoing cardiac angiography or percutaneous coronary intervention (pci).

in the diagnosis and treatment of coronary heart disease, patients should undergo cardiac angiography or percutaneous coronary intervention (pci). in those procedures, the investigators should use the contrast media, and it may cause kidney toxicity especially in the patients with chronic renal insufficiency.

Eligibility criteria:
inclusion criteria: * 18 years old or older * plan to undergo cardiac catheterization * signed icf * egfr: 30\~59 ml/min/1.73m2 exclusion criteria: * pregnancy * under dialysis * conditions interfering with cardiac catheterization * participation in other trials * allergic to x-ray contrast media * administration of any investigational drug within the previous 30 days * intra-arterial or intravenous administration of iodinated contrast medium from 7 days before to 72 hours after the administration of study drug * left ventricular ejection fraction (lvef) less than 30% by ultrasound examination * intake of any nephrotoxic medications 24 hours before or after the administration of study drug

Keywords: contrast induced nephropathy cin cardiac catheterization
endourological management of stones during covid19

Conditions: Urolithiasis; COVID-19

Summary: guidelines for endourological procedures during covid-19 have suggested deferring all elective procedures, while obstructed/ infected stones should undergo urgent decompression. at our centre, screening protocols were implemented with prioritization strategies so that elective care could safely continue at deescalated rates. covid or septic patients underwent emergency decompression, while non-covid and non-septic patients underwent primary ureteroscopy (urs) or retrograde intrarenal surgery (rirs). we aim to report our experience with endourological surgery for stone disease during covid-19.

we conducted a retrospective review of a prospectively maintained database of all endourological surgeries for stones in our centre during the first wave of covid19.

Eligibility criteria:
inclusion criteria - all patient with urolithiasis who underwent endourological interventions during covid19 pandemic

Keywords: endourology pandemic