Kornimate/medical-research-clean huggingface dataset:
acute consumption of pecan-enriched meal

Conditions: Healthy

Summary: pecans are a nutrient-dense food, but it is unknown whether substituting pecans for a portion of the butter in a traditional breakfast meal improves post-meal responses.

this study was a randomized, double-blind control trial consisting of 2 study visits for 2 different treatments. the treatments were high-fat breakfast muffins containing either butter (control) or pecans. the investigators recruited healthy, normal-weight adults between the ages of 15 and 45y. study visits were completed in a random order with at least 72 hours between each visit. anthropometrics, questionnaires, and fasting and postprandial blood samples were collected at each visit. hypothesis: the pecan-enriched meal will blunt the post-meal increase in glucose, insulin, triglycerides (tg), and lipid peroxidation while improving all measures of subjective appetite and tac compared to the traditional meal without nuts.

Eligibility criteria:
inclusion criteria: * healthy adult men and women * normal-weight (body mass index = 18-24.9kg/m2) exclusion criteria: * allergies to test meal ingredients (gluten, eggs, or nuts) * medication/supplement usage * chronic disease * pregnancy or plans to become pregnant * special diets * tobacco use
effectiveness of modafinil and d-amphetamine in treating cocaine dependent individuals

Conditions: Cocaine-Related Disorders

Summary: cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found. the purpose of this study is to examine the effects of d-amphetamine and modafinil, when given alone and in combination, in treating cocaine dependent individuals.

cocaine is a strong central nervous system stimulant that is widely abused throughout the united sates. due to its widespread use, it is important to develop an effective treatment for cocaine dependence. modafinil is a glutamate-enhancing agent. d-amphetamine is a central nervous system stimulant that is approved to treat individuals with narcolepsy and attention deficit disorder. both modafinil and d-amphetamine may be effective treatments for cocaine dependence. the purpose of this study is to examine the effectiveness of modafinil and d-amphetamine, alone and in combination, in treating cocaine dependent individuals. this study will last 16 weeks. participants will be randomly assigned to one of four groups: 1) 60 mg dose of d-amphetamine; 2) 400 mg dose of modafinil; 3) 30 mg dose of d-amphetamine combined with 200 mg dose of modafinil; and 4) placebo. all participants will receive 200 mg of modafinil over 4 days.

Eligibility criteria:
inclusion criteria: * meets structured clinical interview for diagnostic and statistical manual of mental disorders-iv (scid) criteria for cocaine abuse or dependence * in general good health. individuals who are hiv-positive will not be excluded if in good general health, unless medication interactions exist. exclusion criteria: * meets diagnostic criteria for psychiatric disorders, including other forms of drug dependence, other than nicotine * current cardiovascular disease, as determined by an electrocardiogram * on probation or parole if the circumstances do not allow study completion or if ethical constraints of supervision do not allow confidentiality * previously received treatment with d-amphetamine, modafinil, or aripiprazole * currently receiving prescribed medication
gene expression changes in young and geriatric skin

Conditions: UVB Phototherapy Burn; Insulin-like Growth Factor 1; Aging

Summary: this study does not involve any particular diagnosis. the goal of this research study is to explore the effects of artificial sunlight (ultraviolet b radiation; uvb) on the skin of young adults versus geriatric adults. sunlight exerts many effects on the body. there is evidence that in response to ultraviolet b radiation (uvb), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. in fact, researchers feel that this difference in how the skin reacts to uvb is why skin cancers are found in older skin. researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (igf-1), whereas geriatric skin has very little. the current study will test how young adult versus geriatric skin responds to uvb, and if geriatric skin treated with an injection of small amount of igf-1 drug will then act like young skin.


Eligibility criteria:
inclusion criteria: * male/female * white skin (fitzpatrick types i and ii) * age 21-30 or 65 and older * able to comprehend procedures/risks exclusion criteria: * known photosensitivity * currently on photosensitizing medications * diabetes mellitus * history of abnormal scarring * history of skin infections * known allergy to lidocaine local anesthetic * pregnancy or nursing * other serious health issues
quantitative sensory psychophysical correlates of pain in pregnant women with oud

Conditions: Opioid-use Disorder; Pregnancy Related

Summary: this is a prospective observational case-control study comparing quantitative sensory testing data preformed during the third trimester of pregnancy and within 24 hours postpartum in women on medication-assisted treatment for opioid use disorder (oud) to a gestational age-controlled cohort of women who do not have oud. the primary goal is to measure elements of quantitative sensory testing including temperature pain threshold, temperature pain tolerance, and thermal and mechanical temporal summation for patients with opioid use disorder on medication-assisted treatment (mat), and compare these results to gestational age matched controlled pregnant patients not on mat.

the objective of this study is to measure elements of quantitative sensory testing including temperature pain threshold, temperature pain tolerance, and thermal and mechanical temporal summation for patients with opioid use disorder on medication-assisted treatment (mat), and compare these results to gestational age matched controlled pregnant patients not on mat. the hypothesis is that women requiring maintenance opioids during pregnancy will have a significant difference in pain sensitivity in the third trimester and immediately postpartum as compared to women who did not require maintenance opioids during pregnancy.

Eligibility criteria:
inclusion criteria: subjects that will be included in the prospective cohort group: * individuals at least 18 years of age * at least 28 weeks gestation (third trimester) * on medication-assisted treatment for opioid use disorder, including methadone or suboxone. patients who will be included in the control group: * individuals at least 18 years of age * at least 28 weeks gestation (third trimester) * have not been on been on opioids in the past 12 months. exclusion criteria: * those who are unable to participate in informed consent discussions, * unable to give informed consent for any reason, * not fluent in english (surveys are validated in english language) * unable to participate fully in all study procedures for any reason including sensory deficits, scar tissue, or infection at any qst sites.
health education model led by community health volunteers.

Conditions: Schistosomiasis; Health Education

Summary: the goal of this intervention study is to investigate the level of knowledge, attitudes, and behaviors of students on schistosomiasis in pemba island. it aims to test the effectiveness of establishing a widely applicable community health volunteers model in the zanzibar region and explore the feasibility of promoting this model in other areas of africa. this study also aims to provide valuable insights and references for global schistosomiasis prevention and control efforts.

the main questions it aims to answer are: conducting a survey to understand the current knowledge levels, attitudes, and relevant health behaviors of pemba island students towards schistosomiasis. performing qualitative research to analyze the factors influencing students' knowledge, attitudes, and behaviors related to schistosomiasis, as well as observing the facilitators and barriers to conducting health education among student groups, in order to provide a scientific basis for targeted intervention measures. testing the effectiveness of establishing a widely applicable community health volunteer model in the zanzibar region and exploring the feasibility of promoting this model in other regions of africa, thereby providing insights and references for global schistosomiasis prevention and control efforts. participants will select fourth and fifth grade students from two schools located in high-risk schistosomiasis prevalence areas on pemba island, with kilindi primary school as the intervention group and shumba viamboni or chambani primary school as the control group from feb 2024 to feb 2025. apart from the kap survey, urine samples will be collected from students three times at least and the prevalence confirmed to compare the effectiveness of the two groups.

Eligibility criteria:
inclusion criteria: * individuals whose grades fall within the scope of the survey students who have not received health education intervention on schistosomiasis conducted by community health volunteers students or parents who agree to sign informed consent and participate in the study students residing in schistosomiasis-endemic areas exclusion criteria: * students whose grades are not within the scope of the survey students who have already received health education intervention on schistosomiasis students or parents who refuse to sign informed consent or participate in the study students who have been diagnosed with other serious illnesses.

Keywords: schistosomiasis chvs kap
setting up a warehouse of physiological data and biomedical signals in adult intensive care

Conditions: Critical Illness

Summary: the aim of this study is the establishment of a warehouse physiological data and biomedical signal in intensive care adult patients in acute situations from particular records from the philips intellivue mp70 monitor.

cardiopulmonary failures are major public health concerns, due to the aging population. each of these situations is burdened with a poor prognosis in the medium term and a source of prolonged hospitalizations, generating significant health costs. early detection and prediction of organ failure could reduce health costs and risks for the patient, offering a reaction early and appropriate medical technology. the proposed approach aims to optimize the knowledge of a complex physiological domain and multi-system, while promoting the automatic transfer of knowledge. the approach proposed data-mining and development of algorithms for detecting and / or predicting a strong potential for disruption because it proposes to apply innovative automated analysis procedures to a fragile patient population, and then a transfer to the medical device industry. from communicating tools of recording of the signals, the investigator envisage in a global way: 1. the constitution of a warehouse of physiological data of grown-up patients in acute situation (intensive care unit); 2. the development by data mining of a system of detection of organs failures or adverse events basing itself on the application of innovative algorithms, allowing the decision-making operational, from the fusion of arisen ill-assorted events; 3. the use of intelligent tools of auto-learning and elaboration of complex multimodal models for purposes of prediction of events;

Eligibility criteria:
inclusion criteria: * any adult patient admitted in brest university hospital's intensive care unit for monitoring of vital failure exclusion criteria: * refusal to participate

Keywords: data warehousing data aggregation data mining
in market utilisation of liraglutide used for weight management in the uk: a study in the cprd primary care database

Conditions: Obesity; Overweight

Summary: this study is conducted in europe. the aim of this study is to investigate the usage of liraglutide for weight management in clinical practice using the cprd (clinical practice research datalink) primary care database.


Eligibility criteria:
inclusion criteria: -new initiators of liraglutide (unbranded, or branded prescription, i.e. saxenda® or victoza®), who have no liraglutide prescriptions in the twelve months prior to index date (time of first prescription). patients must be research standard (registered as "acceptable" in the database) with at least one year of up-to-standard registration prior to their index date exclusion criteria: -not applicable
ultrasound detection of radiographically negative fractures of elbow in children

Conditions: Fractures, Bone

Summary: fractures of an elbow are common in children. accurate initial diagnosis is crucial for the management of the fractures of an elbow. in young children the fractures may be suspected clinically but missed on x-rays due to mostly non-ossified cartilage that is not visible on a regular x-ray. we propose that every x-ray negative, but clinically suspicious elbow trauma in children can be additionally evaluated using high resolution us.


Eligibility criteria:
inclusion criteria: * signing informed consent exclusion criteria: * unwillingness to sign informed consent. * any fracture of the same hand or forearm before or after an avaluated event.
management of recurrent croup

Conditions: Croup

Summary: presently children who experience recurring croup symptoms receive a variety of treatments. this is because it is not clear which treatments may be best. some children are given inhaled steroids (similar to what children with asthma use). others are carefully watched and cautioned to avoid potential triggers (certain foods, environmental allergens, etc), and should episodes of croup recur they are treated with a short course of oral steroids. the purpose of this study is to compare two safe and clinically appropriate methods for treating recurrent croup, daily inhaled steroids versus observation with oral steroids on an as needed basis, to see if either is useful in preventing future episodes of croup.


Eligibility criteria:
inclusion criteria: * pediatric population: 6 months to 15 years of age * 2 or more episodes of croup in 12 month period * croup defined as acute onset inspiratory stridor, barking cough, with respiratory distress. exclusion criteria: * grade 3 or 4 subglottic stenosis * subglottic hemangioma * posterior laryngeal cleft * recurrent respiratory papillomatosis * external compression (innominate artery compression, mediastinal mass, (double aortic arch, etc) * symptoms or signs suggesting another cause of stridor, such as epiglottitis, bacterial tracheitis, or supraglottic foreign body * tracheomalacia/ bronchomalacia severe enough to cause respiratory distress * current steroid therapy for previously diagnosed condition, i.e. reactive airway disease. * other medical conditions necessitating chronic steroid utilization

Keywords: croup recurrent croup barky cough
concentrated citrate locking to reduce the incidence of cvc-related complications in hematological patients

Conditions: Hematological Malignancies; Bacteremia; Thrombosis

Summary: patients with a hematological malignancy who are undergoing intensive chemotherapy need a central venous catheter (cvc)during their treatment. cvcs are locked with heparin when they are not used. the purpose of this study is to determine whether concentrated citrate locking, compared to heparin, reduces the incidence of central venous catheter-related thrombosis and infections in patients with hematological malignancies undergoing intensive chemotherapy.

central venous catheter (cvc)-related thrombosis and infections are frequently occurring complications and may cause significant morbidity in patients with hematological malignancies. interventions to decrease fibrin deposition have the potential to reduce cvc-related thrombosis and infections. at present heparin is most often used as locking solution for central venous catheters in hematological patients despite a lack of evidence regarding the efficacy and safety. trisodium citrate (tsc) had been shown to be an effective antimicrobial catheter locking in hemodialysis patients.

Eligibility criteria:
inclusion criteria: * patients with hematological malignancies who were going to receive a cvc for intensive chemotherapy including patients for stem cell transplantation * written informed consent * 18 years or older exclusion criteria: * the presence of a central venous catheter at admission * history of central venous catheter related thrombosis or infection * indication for anticoagulant treatment or prophylaxis * patients with totally implanted catheters * catheters impregnated with antimicrobial agents

Keywords: hematological patients central venous catheters catheter related thrombosis catheter related infections concentrated citrate
oxis 9mcg turbuhaler clinical experience investigation

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the purpose of the investigation is to confirm the adr development and the contributing factors possibly having an impact on the safety under the post-marketing actual use of oxis 9 mcg turbuhaler.

oxis 9mcg turbuhaler clinical experience investigation

Eligibility criteria:
inclusion criteria: - patients treated with oxis for the first time due to 'relief of various symptoms associated with airway obstructive disorders of chronic obstructive pulmonary disease (chronic bronchitis, pulmonary emphysema), which is the indication of this drug.

Keywords: chronic obstructive pulmonary disease, copd, oxis,
neonates with very low birth weight and surgery therapy of acute abdomen

Conditions: Very Low Birth Weight

Summary: objective: due to high mortality rates the capillary leakage and the acute abdomen are important risk factors of the probability of survival. the aim of an optimal therapy of the acute abdomen within the neonatal period is beside the cure of the underlying disease the prophylaxis of capillary leakage with the help of optimised intra- and postoperative volume therapy. question: do the neonates with very low birth weight and a surgery therapy of acute abdomen benefit from early increase of the haemoglobin/haematocrit by optimised volume therapy with crystalloid and colloidal volume as prophylaxis of the capillary leakage?


Eligibility criteria:
inclusion criteria: * all children with very low birth weight who have undergone surgery of acute abdomen within the neonatal period between 2001 and 2011 on "campus charité mitte" or "charité virchow - klinikum". * neonates (calculated date of birth + 4 weeks) exclusion criteria: * birth weight \> 1500g

Keywords: capillary leakage acute abdomen low birth weight
effects of pilate training versus moderate intensity continous training in hypertensive patients

Conditions: Prehypertension

Summary: hypertension, commonly known as high blood pressure, continues to be the leading cause of both sickness and mortality globally. generally, individuals in good health might have trouble breathing solely during vigorous exercise or when holding their breath, finding relief by stopping the activity or adjusting their breathing technique. often patients with hypertension seek various treatments to relieve symptoms. the aim of this study is to compare the effects of pilates training and moderate intensity continuous training on dyspnea and cardiovascular fitness in hypertensive patients. the study would be randomized clinical trial. a total of thirty-four subjects will be assigned randomly by using block randomization into two groups. group a will be given pilates training while group b will moderate intensity training. after confirmation of diagnosis with medical history and physical examination as well as chronic, mild-to moderate, and stable (\>1 year duration) hypertension (systolic blood pressure \[sbp\] between 140-179 mm hg and diastolic blood pressure \[dbp\]between 90-109 mm hg) recommended. 3-minute step test, vo2max and modified borg scale would be used as an outcome measure tools for cardiovascular parameters and dyspnea. the collected data will be analyzed in spss 25.0. descriptive and inferential statistics will be applied after testing normality of data


Eligibility criteria:
inclusion criteria: * participants must be between 45 to 70 years old * gender: male and female both * chronic, mild-to moderate, and stable (\>1 year duration) hypertension (systolic blood pressure * \[sbp\] between 140-179 mm hg and diastolic blood pressure \[dbp\] between 90-109 mm hg). * single antihypertensive medication will be recruited. * participants have sedentary life style. * smokers, alcoholic, diabetic, and other cardiac problems (controlled) would be included. exclusion criteria: * patients with permanent atrial fibrillation * patients with copd * patients with heart surgery * patients with presence of symptomatic congestive heart failure * smokers, alcoholic, diabetic, and other cardiac, renal, and respiratory disease patients (uncontrolled) would be excluded. * participants with no history of psychiatry or psychological disorders or abnormalities.

Keywords: hypertension, dyspnea, pilates training, modified-intensity training
teclistamab in previously treated al amyloidosis

Conditions: AL Amyloidosis

Summary: this is a phase ii study in patients with previously treated immunoglobulin light-chain (al) amyloidosis to evaluate the efficacy and safety of teclistamab


Eligibility criteria:
inclusion criteria: * biopsy confirmed al amyloidosis * patients must have received at least one line of treatment, including daratumumab and bortezomib * relapse from previous treatment, or less than partial response after two cycles of treatment/less than very good partial response after three cycles of treatment * dflc \> 50mg/l exclusion criteria: * previous anti-bcma targeted therapy * co-morbidity of uncontrolled infection * co-morbidity of other active malignancy * co-diagnosis of multiple myeloma or waldenstrom macroglobulinemia * co-morbidity of grade 2 mobitz ii or grade 3 atrioventricular block (expect for those with implanted pacemaker) * co-morbidity of sustained or recurrent nonsustained ventricular tachycardia * seropositive for human immunodeficiency virus * hepatitis b virus (hbv)-dna \> 1000 copies/ml * seropositive for hepatitis c (except in the setting of a sustained virologic response) * neutrophil \<1×10e9/l, hemoglobin \< 8g/dl, or platelet \< 75×10e9/l. * severely compromised hepatic or renal function: alanine transaminase (alt) or aspertate aminotransferase (ast) \> 5 × upper limit of normal (uln), total bilirubin \> 2 × uln, egfr \< 20 ml/min, or receiving renal replacement therapy