Kornimate/medical-research-clean huggingface dataset:
angina, physiology, biology (angina, fisiologia biologia)

Conditions: Angina Pectoris

Summary: relationship between invasive physiological assessment with ffr and imr and biological markers as micro-rna's according to coronary vascular compartiment affected (group 1: macrovasculature + / microvasculature +; group 2: macrovasculature + / microvasculature -; group 3: macrovasculature - / microvasculature +; group 4: macrovasculature - / microvasculature -). also, biological markers will be related with presence of microvascular spasm or macrovascular spasm (group 5).

patients with chest pain suggestive of angina after ruling out other cardiac and non-cardiac causes, referred for invasive coronary angiography, will be evaluated by coronary angiography and invasive coronary physiological assessment by determining ffr and imr and by performing a vasoreactivity test with acetylcholine. a relationship will be established between the invasive physiological assessment with ffr and imr and biological markers such as micro-rna's according to the affected coronary vascular compartment (group 1: macrovasculature + / microvasculature +; group 2: macrovasculature + / microvasculature -; group 3 : macrovasculature - / microvasculature +; group 4: macrovasculature - / microvasculature -). in addition, the biological markers will be related to the presence of microvascular spasm or macrovascular spasm (group 5). finally, among other biological markers, the following mirnas will be compared. these mirna's present consistent data in the literature about their over or underexpression.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years. 2. patients with chest pain suggestive of angina evaluated by a cardiologist referred for diagnostic coronary angiography and possible coronary intervention. 3. echocardiogram ruling out noncoronary cardiac causes of chest pain. 4. informed consent. exclusion criteria: 1. contrast allergy not susceptible to premedication. 2. severe bronchial asthma or adenosine intolerance. 3. atrio-ventricular block (≥ 2nd degree) or acetylcholine intolerance. 4. acute myocardial infarction with st-segment elevation. 5. acute myocardial infarction without st-segment elevation. 6. cardiogenic shock. 7. total occlusion of any coronary artery that precludes measurements with pressure-temperature guidewires. 8. previous coronary artery bypass grafting. 9. women with the possibility of being pregnant. 10. renal dysfunction with an estimated glomerular filtration rate \<30 ml/min/1.73m2. 11. inability to understand the nature of the study and / or sign informed consent. 12. any other medical condition that, in the opinion of the researcher, may lead to safety issues for patients or may alter the results of the study.

Keywords: coronary physiology biology mirna fractional flow reserve index of microcirculatory resistance angina pectoris
a methodological study to evaluate the effects of single oral doses of pioglitazone 45 mg and rosiglitazone 8 mg on sodium balance in healthy male volunteers

Conditions: Type 2 Diabetes Mellitus

Summary: a single centre, open, randomized, placebo controlled, 3 period cross-over study to evaluate the effects of single oral doses of pioglitazone 45mg, rosiglitazone 8mg and placebo on urinary sodium excretion in 12 healthy male volunteers


Eligibility criteria:
inclusion criteria volunteers with body mass index 18.0-28.0 kg/m2 exclusion criteria clinically relevant medical history

Keywords: urinary sodium excretion pioglitazone rosiglitazone methodological study
preventing non-communicable diseases in guatemala through sugary drink reduction

Conditions: Food Preferences

Summary: sugar-sweetened beverages are a significant contributor to adult and childhood obesity in guatemala. policies to place health warning labels on sugar-sweetened beverages are being pursued, but there is little empirical data on how such labels influence people. the primary aim of this study is to test the association between sugar-sweetened beverage (ssb) warning posters compared to control posters and change in ssbs purchased compared to baseline by adolescents shopping at school cafeterias in guatemala city, guatemala. the hypothesis is that posters with information warning people of the health harms associated with overconsuming ssbs and promoting low sugar beverages will be associated with greater reductions in ssb purchases compared to a control poster.


Eligibility criteria:
inclusion criteria: * between 12 and 18 years old * made a food or beverage purchase * has permission from parent or caregiver to participate * has not yet completed the purchase assessment exclusion criteria: * under 12 or over 18 years old * did not make a food or beverage purchase * parent or caregiver refused to give child permission to participate * already participated in the purchase assessment

Keywords: food labeling adolescents
the german italian spanish takotsubo (geist) registry

Conditions: Takotsubo Syndrome

Summary: geist is a multicenter, international observational registry of patients with takotsubo syndrome. data regarding the clinical profile (demographic characteristics, clinical presentation, laboratory measures, electrocardiography /echocardiography / coronary angiography parameters, treatment and medication), in-hospital course and complications and short-/long-term outcome are collected prospectively and retrospectively to increase the understanding of the disease.

the open-ended, multicenter, international geist registry collects data from patients with takotsubo syndrome during the index hospitalization and follow-up. furthermore, long-term outcome data are acquired with structured telephone interviews, in case patients do not undergo regular outpatient visits in the participating study centers. the geist registry retrospectively includes data, which have already been collected, and prospectively continues to enroll patients with newly diagnosed takotsubo syndrome.

Eligibility criteria:
inclusion criteria: * patients with takotsubo syndrome exclusion criteria: * non
effects of neuromuscular reeducation versus friction massage in lateral epicondylitis

Conditions: Lateral Epicondylitis

Summary: this study is a randomised control trial and the purpose of this study is to determine the effects of neuromuscular reeducation versus friction massage in lateral epicondylitis.

participants will be recruited into their respective groups using a coin toss method. lateral epicondylitis will be assessed using the following tests: cozen's test maudsley's test mills test

Eligibility criteria:
inclusion criteria: 1. diagnosed cases of lateral epicondylitis 2. age 25-50 years 3. both genders 4. postive tests; cozens, maudsley's, mills (at least any of 2) exclusion criteria: 1. recent elbow fractures or dislocations 2. elbow joint instability 3. active joint disease 4. open wounds around elbow joints
study with norucholic acid tablets in patients with primary sclerosing cholangitis (psc)

Conditions: Primary Sclerosing Cholangitis

Summary: open-label, multi-center, phase iii trial. oral treatment with 1500 mg norucholic acid in primary sclerosing cholangitis


Eligibility criteria:
inclusion criteria: 1. signed informed consent. 2. males or females ≥ 18 years. 3. patient has previously been diagnosed with psc, has participated in the previous nuc 5/psc trial and has completed the dbe phase with visit 22, or has prematurely terminated the dbe phase before this trial has been started, or has prematurely terminated the dbe phase after this trial has been started, under the condition that the premature termination was due to lack of efficacy\*. (\*lack of efficacy as defined in the nuc-5/psc trial.) exclusion criteria: 1. history or presence of chronic alcoholic consumption (daily consumption \> 30 g in men, \> 20 g in women). 2. patients who discontinued study participation in nuc-5/psc due to an ae possibly caused by the study drug. 3. liver cirrhosis or any cirrhosis-related symptoms which in the opinion of the investigator may affect the patient's safety. 4. history of liver transplantation or patient listed for transplantation.
acute effect of resistance exercise, neuromuscular electrical stimulation, and transcutaneous electrical stimulation applications on muscle activation

Conditions: Motor Activity

Summary: the aim of our study is to investigate the effects of single-session resistance exercise, neuromuscular electrical stimulation, and transcutaneous electrical stimulation on the level of muscle activation and their superiority over each other on both the ipsilateral and contralateral sides. our randomized controlled crossover study included 21 participants (13 female, 8 male, age; 27.7±4). transcutaneous electrical stimulation was used for sensory input. a single-session application was performed only to the right extremities of all participants, and the acute effects on muscle activation on both the ipsilateral and contralateral sides were evaluated. muscle activation was evaluated with superficial emg. spss® statistics v22.0 software was used for statistical analysis. as a result of the statistical analysis, a significant increase in activation was found only in the sensory input application group on the ipsilateral side flexor carpi radialis (fcr) (p=0.001), flexor carpi ulnaris (fcu) (p\<0.001), flexor digitorum superficialis (fds) (p=0.023) and flexor digitorum profundus (fdp) (p=0.003) muscles. on the contralateral side, there was an increase in activation in all muscles (fcr; p\<0.001, fcu; p=0.033, fds; p=0.017 and fdp; p=0.001) in the resistant exercise group. in addition, there was a significant increase in the activation of certain muscles on the contralateral side in the nmes application group (fcr (p=0.049) and fdp (p=0.016) muscles) and the sensory input application group (fdp (p=0.004) and fds (p=0.043) muscles). in situations where movement is contraindicated, ipsilateral sensory input can increase the level of muscle activation through both cortical and peripheral neural mechanisms.in addition, resistance exercise to be performed on the contralateral side can be an effective application to increase muscle activation on the ipsilateral side.


Eligibility criteria:
inclusion criteria: • after providing detailed information about the study, individuals who had agreed to participate in the research were included in the study. exclusion criteria: * individuals with any central or peripheral nervous system disease/injury affecting the upper extremity, * individuals with a history of orthopedic injury that could impact the study, * individuals with a history of neuromuscular disease, congenital anomalies, skin infections, or cognitive impairments, * individuals with a history of systemic or metabolic diseases that could potentially affect the study, * individuals with a body mass index (bmi) above 30 kg/m2.
coronary ct angiography using a novel 3rd generation dual-source ct system

Conditions: Coronary Artery Disease

Summary: coronary ct angiography is used to examine the coronary arteries in a non-invasive way when a patient is suspected of having coronary artery disease. the test, however, requires relatively high levels of radiation, which have been linked to dna damage and cancer, and the use of contrast material, which can affect kidney function. the somatom force, a new third-generation ct scanner manufactured by siemens, was recently installed at musc and holds the potential to obtain quality images while also reducing radiation dose and contrast material. this study aims to test the diagnostic ability of the somatom force in detecting coronary artery disease and also see if radiation dose and contrast material are reduced compared to the previous 2nd generation scanners. it is suspected that the force will provide clinical quality images while decreasing radiation dose and contrast material required.


Eligibility criteria:
inclusion criteria: * subject must be between 18-90 years of age. * subject must have been referred for a clinically indicated cardiac catheterization or nuclear cardiac perfusion study. * subject must provide written informed consent prior to any study-related procedures being performed. * subject must be willing to comply with all clinical study procedures. exclusion criteria: * subject is a pregnant or nursing female. exclude the possibility of pregnancy: * by testing (urine βhcg) within 24 hours before contrast agent administration, or * by surgical sterilization, or * post menopausal, with minimum one (1) year history without menses. * subject has an acute psychiatric disorder or is cognitively impaired. * subject is using or is dependent on substances of abuse. * subject is unwilling to comply with the requirements of the protocol. * subject has decreased renal function (egfr \<45) * subject has an allergy against iodinated contrast agents. * subject is in acute unstable condition.
gs-5885 alone or in combination with gs-9451 with peginterferon alfa 2a and ribavirin in treatment chronic genotype 1 hepatitis c virus

Conditions: Hepatitis C, Chronic

Summary: this is a phase 2b, randomized, double-blind, placebo-controlled trial evaluating response guided therapy with gs-5885 alone or in combination with gs-9451 with peginterferon alfa 2a and ribavirin in treatment naïve subjects with chronic genotype 1 hepatitis c virus infection.


Eligibility criteria:
inclusion criteria: * males and females 18-70 years of age * chronic hcv infection * subjects must have liver biopsy results (≤ 2 years prior to screening) indicating the absence of cirrhosis. * monoinfection with hcv genotype 1 * hcv rna \> 10\^4 iu/ml at screening * hcv treatment naïve * candidate for peg/rbv therapy * body mass index (bmi) 18-36 kg/m2, inclusive * agree to use two forms of highly effective contraception methods for the duration of the study and for 7 months after the last dose of study medication. females of childbearing potential must have negative pregnancy test at screening and baseline. exclusion criteria: * pregnant female or male with pregnant female partner * exceed defined thresholds for leukopenia, neutropenia, anemia, thrombocytopenia, thyroid stimulating hormone (tsh) * diagnosis of autoimmune disease, decompensated liver disease, poorly controlled diabetes mellitus, significant psychiatric illness, severe chronic obstructive pulmonary disease (copd), hiv, hepatitis b virus (hbv), hepatocellular carcinoma or other malignancy (with exception of certain resolved skin cancers), hemoglobinopathy, retinal disease, or are immunosuppressed. * subjects with current use of amphetamines, cocaine, opiates (e.g., morphine, heroin), or ongoing alcohol abuse are excluded. patients on stable methadone or buprenorphine maintenance treatment for at least 6 months prior to screening may be included into the study.

Keywords: hepatitis c hcv rapid virologic response sustained virologic response direct acting antiviral combination therapy hcv rna protease inhibitor treatment naïve gs-5885 gs-9451
a prospective cohort study of heart patients included in exercise based rehabilitation in oslo

Conditions: Cardiac Disease

Summary: outcomes evaluation is a critical component in outpatient cardiac rehabilitation. the aim of this study is to examine factors who predict long-term effects of improved peak oxygen uptake one year after participating in cardiac rehabilitation. secondary to evaluate the short and long-term outcome of a 12-week outpatient cardiac rehabilitation program.

a prospective cohort study including all cardiac patients referred for outpatient cardiac rehabilitation in a primary care clinic in oslo. the main efficacy variable is the changes in exercise capacity (vo2peak) as a primary prognostic measure of successful rehabilitation. hrqol are measured by self-report using the coop/wonca questionnaire and sf-36.

Eligibility criteria:
inclusion criteria: * stable coronary heart disease * valvular surgery * refered to high-intensity exercise training from a cardiologist exclusion criteria: * acute myocardial infarction within four week * serious rhythm disturbances * unstable angina pectoris * known significant comorbidity * symptomatic peripheral vascular disease * obstructive pulmonary disease with forced expiratory vital capacity \< 60% of predicted * left ventricular ejection fraction \< 40%

Keywords: exercise, cardiac rehabilitation, quality of life
a study to assess the virus rna, and mirna levels related to viral infection, and inflammatory response in tears of patients affected by covid-19 disease

Conditions: COVID; Conjunctivitis

Summary: the aim of this study is to assess the virus rna, and mirna levels related to viral infection, and inflammatory response in tears of hospitalized patients with a diagnosis of covid-19 with and without conjunctivitis and to correlate them with clinical condition. tears will be collected by using schirmer test i, a non invasive painless test which can be performed at the patient's bed. tears will be collected on the graduated paper strips pulling the lower lid gently downward for 5 minutes. following, the strip will be placed in a 2.0 ml eppendorf tube and stored at -80◦c (or - 20°c)

the sars-cov-2 is a virus highly infectious whose main target of infection is the respiratory tract. virus has been reported to target other mucus tissues, such as the conjunctiva of the eye and causes conjunctivitis. a recent study has detected the presence of sars-cov-2 in the tears of patients affected by covid-19 with conjunctivitis, using real-time reverse transcription polymerase chain reaction (rt-pcr). this suggests that droplets and body fluids of infected people can contaminate the human conjunctival mucosa and it can be a view of transmission that it must not be ignored. a role of mirnas has been found in ocular infections such as fungal, bacterial, viral infections. it would be interesting to correlate tear fluid mirna levels to patients clinical findings

Eligibility criteria:
inclusion criteria (group 1): * a confirmed diagnosis of covid-19 disease * age ≥ of 18 years. * absence of conjuntivitis detected by portable slit lamp inclusion criteria (group 2): * a confirmed diagnosis of covid-19 disease * age ≥ of 18 years. * presence of bilateral conjunctivitis defined as red eyes (macroscopic signs of conjunctival congestion) exclusion criteria (both groups): * pregnant women * any form ocular surface diseases preceding covid-19 diagnosis, glaucoma, history of anterior segment inflammation, previous penetrating ocular trauma * ocular surgeries within previous 6 months * topical therapies * history of ocular allergy

Keywords: covid conjunctivitis sars-cov2 mirna tear fluid
long term effects of lutein/zeaxanthin and omega-3- supplementation for two more years (lutega 2)

Conditions: Age Related Maculopathy

Summary: the primary objective of lutega 2 is it to determine the long term effect (about 2 more years after lutega 1, nct00763659) of the supplementation with a fixed combination of lutein/zeaxanthin and omega-3- fatty acids in two different dosages on the optical density (od) of macular pigment in patients with non- exudative age related maculopathy. the dosage groups are crossed after lutega 1.

the lutega 2 is a cross-over- study and the continue of lutega 1. after one year of supplementation in randomized, placebo- controlled, double blind study (lutega 1), the treatment arms are unblind to cross over the different dosage groups. the measurement of optical density of macular pigment (mpod) uses the 1- wavelength reflection method recording reflection images at 480 nm by a fundus camera. the patients are followed up over two years in eight more visits (every three months) in addition to the mpod- measurement each examination includes standardized visual acuity test (etdrs), amsler- grid, slit lamp biomicroscopy, fundus photography (color and autofluorescence) and a blood sample (every six months).

Eligibility criteria:
inclusion criteria: * all non- exudative forms of age related maculopathy exclusion criteria: * exudative age related maculopathy * decrease opacity of ocular media
cerebellar rtms to improve gait recovery

Conditions: Stroke; Gait, Hemiplegic

Summary: the cerebellum is known to be strongly implicated in the functional reorganization of motor networks in stroke patients, especially for gait an balance functions. repetitive transcranial magnetic stimulation of the cerebellum can be used to enhance these adaptive processes in stroke recovery. in this randomized, double blind, sham-controlled trial we aim to investigate the efficacy and safety of cerebellar intermittent theta burst stimulation coupled with intensive physical therapy in promoting gait recovery in hemiparetic patients due to recent stroke in the territory of the contralateral middle cerebral artery


Eligibility criteria:
inclusion criteria: * first ever-chronic ischemic stroke, i.e. at least 6 months after the stroke event, * left or right subcortical or cortical lesion of the middle cerebral artery with medium-severity stroke nhiss \<15 (all lesions must be documented by magnetic resonance imaging (t1- and t2-weighted images; 1.5t, ge scanners) * no contraindication to brain mri * mep recordable in order to evaluate the resting motor threshold (rmt) exclusion criteria: * epilepsy * severe general impairment or concomitant diseases (tumors, etc.) * age\> 80 years * infections in progress * patients with neurological diseases beyond stroke or with neuropsychiatric disorders or with neuropsychological disorders that could potentially compromise informed consent or compliance during the study. * treatment with benzodiazepines, baclofen, antidepressants, clonidine, beta blockers and other potentially interfering drug treatments on plasticity phenomena.
prognostic value of biomarkers in polyneuropathy.

Conditions: Polyneuropathies

Summary: biomarkers for prognosis of patients with polyneuropathy.

aim: to investigate biomarkers' use as a prognostic tool in polyneuropathy patients. study design: prospective cohort study of patients with polyneuropathy. methods: 200 patients with polyneuropathy will be examined with physical tests, medical examination, questionnaires, and blood biomarkers at baseline and at 1-year follow-up, and 2-year follow-up. analysis: the investigators will calculate the odds of disease progression after 2 years depending on biomarkers levels at baseline using multiple logistic regression with sex and age adjustment. diagnostic performance of the physical tests and biomarkers for prediction of disease progression will be assessed by receiver operating characteristic curve analysis with the area under the curve.

Eligibility criteria:
inclusion criteria: * minimum 18 years old. * diagnosed with polyneuropathy, confirmed by nerve conduction study. * can read and understand danish. exclusion criteria: * inability to perform physical tests due to comorbidity not associated to the patient's polyneuropathy.

Keywords: polyneuropathy biomarkers cohort study