Kornimate/medical-research-clean huggingface dataset:
effect of autologous platelet rich fibrin on post-operative complications and healing following the extraction

Conditions: Pain, Postoperative; Post Operative Swelling; Trismus; Soft Tissue Healing

Summary: as post-operative pain, infection inflammation and infections are the main complications after the surgical extraction of the lower third molar the aim of this study is to compare the healing effects of prf administered postoperatively

prf will be randomly administered into one group of patients undergoing any extractions group a (right after the extraction) group b will be a control group in which extraction sockets will be left to heal with the natural blood clot. consenting patients will be assigned into groups randomly and not informed which group they were placed into. the prf will be administered obtained from a tube of 10 ml blood and no material will be placed in the control group. the progress of healing and post-operative complications will be tracked over a period of 7 days with patients being called for follow-up on days 3, 5 and 7. their post-operative complications will be checked at every subsequent visit and noted in the questionnaire. the questionnaire is structured and will be interviewer-administered. it will comprise of basic bio-demographic data (such as name, age, sex, etc) and 3 closed-ended questions related to post-operative complications following the extraction

Eligibility criteria:
inclusion criteria: 1. both male and female patients 2. patients that give their consent to the use of their information and to the administration of the drug will be the participants of the study. 3. patients with 3rd molar impactions 4. absence of systemic diseases 5. age ⩾18 years and the ability to cooperate with the requirements of the study protocol. exclusion criteria: 1. medically compromised patients. 2. immunocompromised patients. 3. patients that do not consent. 4. patients that are below the age of 17. 5. patients that are pregnant. 6. fully erupted molars will be excluded. smokers (\&gt; 5 a day) will be excluded as well.

Keywords: prf extraction socket post operative complications wisdom tooth extractions surgical extractions
negative pressure wound therapy. therapy effects and the impact on the patient's quality of life

Conditions: Wounds

Summary: wounds have long been a source of suffering for unfortunate victims and in recent years new complementary methods have been developed in areas where traditional wound treatment has been insufficient. treating wounds with negative pressure, vacuum assisted closure® \[vac\], is a relatively new method of treatment and knowledge about its effect on patients is limited. earlier studies haven't been able to answer the question about which groups of patients that are in most favour of the treatment and what impact the treatment has on the patient's quality of life. it is important with further research since an effective and mild wound treatment can decrease suffering and increase quality of life for the patient. wound treatment that does not lead to an achieved treatment goal can lead to a risk for the patient and should be avoided. the project consists of 4 part studies: study 1 and 2 are chart review studies of a consecutive series of patients treated with vac at södersjukhuset during a 3 year period. the patients are described on the basis of medical, surgical and demographical factors. outcome is treatment results and risk factors for a treatment failure. study 3 and 4 are clinical randomised studies with the aim of studying whether treatment with vac provides a faster and more effective healing of acute and postoperative wounds, and in what way the treatment affect the quality of life and pain of the patients, compared to conventional treatment.


Eligibility criteria:
inclusion criteria: * acute wounds with substance defect after primary suture demanding further treatment or wounds not primary sutured * wounds with osteosynthesis, bone or tendon visual regardless wound size * postoperative infections with wound and substance defect demanding further treatment. * fasciotomy on extremity exclusion criteria: * wound size \< 2 cm and depth \< 1 cm * pressure ulcers, open abdomen and chronic ulcers * patients with dementia or mental illness so severe that participation in the study is impossible * patients non in command of the swedish language * ongoing treatment with warfarin

Keywords: acute wounds postoperative wounds
a study to evaluate treatment preferences for japanese participants with muscle-invasive urothelial carcinoma of the bladder

Conditions: Urinary Bladder Neoplasms

Summary: the main purpose of this study is to identify important treatment attributes for post-radical cystectomy (rc) treatment for participants with mibc (muscle-invasive bladder cancer) and assess the relative importance of treatment attributes for post-rc treatment in japan.


Eligibility criteria:
inclusion criteria: * must reside in japan and able to speak/read japanese for the interview/survey * must have a clinical diagnosis of muscle-invasive bladder cancer (mibc): * ypt2-ypt4a or ypn+ mibc, with prior neoadjuvant cisplatin chemotherapy and underwent radical cystectomy * pt3-pt4a or pn+ mibc, without prior neoadjuvant cisplatin chemotherapy and underwent radical cystectomy * must not have received any treatment related to mibc after radical cystectomy exclusion criteria: * determined by the physician as being unsuitable for the study (e.g. having any clinically significant psychiatric disorder, cognitive impairment, or having difficulty with communicating in japanese) * confirmed diagnosis of other primary cancers at the time of obtaining consent * current participation in a mibc clinical trial
early versus late initiation of anticoagulation in mild-to-moderate ais patients with nvaf

Conditions: Acute Ischemic Stroke; Atrial Fibrillation

Summary: the goal of this clinical trial is to compare the effectiveness between early and late initiation of anticoagulation therapy in acute ischemic stroke (ais) patients with non-valvular atrial fibrillation (nvaf). participants will be 1:1 randomized into early or late initiation group. the primary endpoint is early neurological deterioration (end) before discharge.

anticoagulation therapy is effective to prevent ischemic stroke in patients with nvaf who have a history of stroke. recent clinical trials have demonstrated that early initiation of anticoagulation therapy after ais is safe, while no remarkable benefits have been observed. the goal of this clinical trial is to compare the effectiveness between early and late initiation of anticoagulation therapy in ais patients with non-nvaf. participants will be 1:1 randomized into early or late initiation group. the primary endpoint is end before discharge.

Eligibility criteria:
inclusion criteria: * age \> 18 years old * acute ischemic stroke with onset \< 48 hours * have a history or newly diagnosed as nvaf * nihss on admission \<= 8 exclusion criteria: * chronic renal dysfunction (gfr \< 30ml/min) or severe hepatic injury * have a history or newly diagnosed as valvular heart disease * mural thrombus in heart * contraindications of anticoagulation therapy within 12 days after ais, e.g. severe intracranial hemorrhage * received reperfusion therapy, e.g. intravenous thrombolysis and endovascular treatment * concomitant stenosis (\>50%) of carotid artery/intracranial artery, of which the ischemic lesion located within the territory * life expectancy less than 1 year * plan to receive invasive surgery in the following 3 months and have high risk of uncontrollable bleeding * pregnant or lactating women * individuals identified by researchers as unsuitable for participation in the study due to other reasons.
acupuncture to improve quality of life in patients with advanced cancer

Conditions: Ovarian Cancer

Summary: this study will test the feasibility of acupuncture as a complementary therapy for advanced cancer by comparing symptoms and quality of life before and after 8 weeks of acupuncture treatments.

a large percentage of the practice and use of complementary and alternative medicine (cam) in the united states is focused on cancer. whether the cam use is aimed at reducing one's risk of developing cancer or improving the quality of life of a cancer patient during treatment or at the end of life, the public focus on cam and cancer has created a driving force for cancer centers to address the efficacy and science of these methods. currently, the majority of cancer patients do not receive adequate palliative care. acupuncture has been shown to be effective in the treatment of pain and nausea and has also been shown to improve one's general well-being. acupuncture also has some effectiveness in relieving symptoms of anxiety and depression. this study will evaluate the efficacy of acupuncture by traditional chinese medicine clinicians to address the quality of life and symptoms of patients with incurable cancer. women with recurrent metastatic ovarian cancer and similar patients with advanced cancer who are ambulatory and receiving conventional palliative care will be enrolled in this study. patients will continue to receive high-quality, conventional clinical interventions, including chemotherapy and pain and symptom reduction programs. patients will also receive 8 weeks of acupuncture. evaluation tools such as satisfaction with life domains scale for cancer (slds-c), brief pain inventory, and rotterdam symptom check list will be used to assess the acupuncture intervention.

Eligibility criteria:
inclusion criteria * advanced cancer patients, primarily ovarian cancer patients * undergoing palliative care treatment * ambulatory * symptomatic with pain, nausea, and/or an inadequate quality of life * platelets \> 25,000/mm3 * anc \> 500 cells/mm3 exclusion criteria * acupuncture treatment during the 6 months prior to study entry * history of bleeding disorder, such as hemophilia or von willebrand disease * acute psychosis

Keywords: acupuncture quality of life complementary therapies tcm traditional chinese medicine
balloon inflation and plaque morphology in revascularisation (burst)

Conditions: Coronary Artery Disease; Atherosclerosis

Summary: this study will look at the effects of standardised balloon inflation times, pressure and balloon types and atherosclerotic plaque morphology on the procedural results of percutaneous coronary intervention (pci).

patients presenting with symptoms of coronary artery disease (e.g. chest pain - angina) are often treated with stents (referred to as percutaneous coronary intervention, pci). stents treat the cause of symptoms by improving blood flow to the heart muscle through expanding a narrowed, or diseased segment within a coronary artery. the procedure involves the inflation of a balloon to expand the stent inside the artery. as part of standard clinical care multiple balloon inflations are required during the procedure. deficiencies in the expansion of the stent at the time of the procedure are associated serious complications such as stent blockages or re-narrowing of the artery, either of which may not occur until much later. improvements to the technique of stent expansion are therefore highly desirable to improve outcomes for patients. a number of factors are thought to influence the success of the procedure, including: the type of balloon used to inflate the stent, the pressure used and the duration of balloon inflation. another important factor may be the mechanical properties of the narrowed segment of the artery (plaque) and how they interact with the stent. at present however, there is no consensus view and the practise of individual cardiologists consequently remains highly variable. the aim of this study is better characterise relationship between pressure and duration of balloon inflation, type of balloon used and plaque properties during stent procedures using state-of-the-art imaging. although assessment of each of these factors by a cardiologist is already included as part of standard care, our research protocol will focus the analysis into a systematic framework to allow conclusions to be drawn. the findings will used better inform cardiologists of the technical modifications that can help improve stenting procedures and translate to better outcomes for patients.

Eligibility criteria:
inclusion criteria: * patients with symptomatic coronary artery disease (stable angina, non-st elevation acute coronary syndromes) undergoing percutaneous coronary intervention with intracoronary ultrasound (ivus) guidance * patients \> 18 years * de novo coronary stenoses in native coronary arteries * written informed consent exclusion criteria: * st-elevation acute coronary syndrome * haemodynamic instability * cardiogenic shock * severe renal dysfunction (egfr \< 30 ml/min/1.73m2) * in-stent restenosis * chronic total occlusions * saphenous vein and arterial bypass grafts * patients who are currently enrolled in any other study where involvement in this study would involve significant deviation from either protocol

Keywords: percutaneous coronary intervention stent apposition stent deployment stent expansion intravascular ultrasound
a multi-centre study of shoe-worn insoles and knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: shoe-worn insoles (also known as orthotics) can provide symptomatic relief for people with knee osteoarthritis. however, given they act at the feet, and given that many people with knee osteoarthritis also report foot pain, it is important to assess the effects of these devices at both joints. we will conduct a multi-centre randomized pilot trial to determine feasibility and preliminary efficacy.


Eligibility criteria:
inclusion criteria: * medial tibiofemoral oa defined as definitive osteophytes and joint space narrowing in the medial compartment, as confirmed with radiographs * history of knee pain longer than 6 months * average self-reported knee pain of at least 3 out of 10 (using an 11-point numerical rating scale with terminal descriptors of 0 = "no pain" and 10 = "worst pain imaginable") over the 6 months prior to baseline testing * pain in the same foot/feet as the painful knee(s) * ability to communicate in english * show an immediate biomechanical response to the insoles. this final eligibility criterion will be determined from an in-person biomechanical assessment after participants have passed all previous eligibility screening. exclusion criteria: * radiographic evidence of more lateral tibiofemoral oa than medial * knee surgery or intra-articular injection within the previous 6 months * current or recent (within 6 months) corticosteroid use for any reason * presence of a systemic arthritic condition * history of knee joint replacement or tibial osteotomy * any other condition affecting lower limb function * current usage of shoe-worn insoles, or planning to acquire footwear modifications in the next 6 months * any previous experience with insoles that resulted in increased lower limb pain or a self- or clinician-initiated termination of use.

Keywords: knee osteoarthritis orthotics foot pain biomechanics
pain after laparoscopy results from the incision, manipulation of the abdominal organs, and retained co2(back pain)

Conditions: Post Operative Pain, Acute

Summary: postoperative pain after laparoscopy may be localized pain resulting from incision due to many (two or three) punctures (somatic pain) or due to manipulation of the intra-abdominal organs as ovaries, uterus, omentum, and intestine (visceral pain) or shoulder and back pain caused by retained co2 in the peritoneal cavity with its irritation effect on the diaphragm.patients will be divided into two groups: intraperitoneal (ip) group (20 patients):they will receive 100 ml normal saline infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline intraoperatively then intraperitoneal wash of 100 ml normal saline containing 30 mg/kg mgso4 at the end of laparoscopy. intravenous (iv) group (20 patients):they will receive 100 ml normal saline containing mgso4 30 mg/kg infused over 10 min immediately before the induction of anesthesia and then continuous infusion of 500 ml normal saline containing mgso4 (8mg/kg) intraoperatively then intraperitoneal wash using 100 ml normal saline at the end of laparoscopy


Eligibility criteria:
inclusion criteria: 20-44 years old females, (asa) class i-ii exclusion criteria: * patient refusal * allergy to mgso4 * atrio-ventricular conduction abnormalities * drug abuse * renal or hepatic or cardiovascular dysfunction * prior long-term treatment with calcium channel blockers or magnesium

Keywords: mgso4,laparoscopy ,intraperitoneal
a pilot tele-rehabilitation trial for breast cancer survivors

Conditions: Breast Cancer Female

Summary: breast cancer is the leading cancer affecting women in singapore. breast cancer survivors commonly experience declined physical function and quality of life, due to their upper limb morbidity and wound issues post-surgery. rehabilitation therapy can address the aforementioned issues that the survivors may experience during their recovery. no therapy however, can be effective if patients do not utilize them. home-based telehealth (e.g., tele-rehabilitation) self-managed by patients and guided by healthcare professionals can potentially improve the service use and recovery. this study aims to understand the lived experience of post-mastectomy tele-rehabilitation and recovery process among female patients who undergo a unilateral mastectomy for breast cancer.


Eligibility criteria:
inclusion criteria: * female 21 years and over * underwent a recent unilateral breast surgery (wide excision or simple mastectomy) with lymph nodes removed * speak and write english or mandarin; * no psychiatric history or chronic psychiatric condition as assessed by referring clinician exclusion criteria: * having breast reconstruction * having legal blindness or severe visual impairment * having life expectancy of less than three months (12- weeks) * having previous upper limb injury or conditions that limit passive ranges of shoulder flexion (\<150°), elbow extension/flexion (0/145°)
system accuracy of a blood glucose monitoring system glucospark/glucoscore

Conditions: Diabetes Mellitus

Summary: this study assesses the system accuracy a blood glucose monitoring systems pursuant to iso 15197

this study assesses the system accuracy the blood glucose monitoring systems for personal use gucosaprk/glucoscore as outlined in din en iso 15197:2015.

Eligibility criteria:
inclusion criteria: * male or female patients with clinical indication for blood glucose testing * signed form of consent * minimum age of 18 years * subjects are legally competent and capable to understand character, meaning and consequences of the study exclusion criteria: * pregnancy or lactation * severe acute disease (at study physician's discretion) * acute or chronic diseases with inherent risk of aggravation by the procedure (at study physician's discretion) * current constitution that does not allow participating in the study (e.g. hematocrit out of the devices's specifications, medication known to influence blood glucose measurements; appendix a of iso 15197) * being unable to give informed consent * age younger than 18 years * legally incompetent
a rct of ube vs. mis-tlif in lumbar spondylolisthesis

Conditions: Lumbar Spondylolisthesis; Unilateral Biportal Endoscopy; Minimally Invasive Technique; Surgical Treatment

Summary: unilateral biportal endoscopy (ube) is a new spinal minimally invasive technique improved for the treatment of lumbar spondylolisthesis (lsp). the present study aims to establish a multicenter, large sample, randomized controlled study to explore the technical advantages and surgical indications of this new technique in the treatment of lsp by comparing with the classical minimally invasive posterior spinal interbody fusion; to compare the postoperative clinical and imaging results and analyze the surgical complications and preventive measures.

lumbar spondylolisthesis (lsp) is the most common degenerative lumbar disease in the elderly, and the severe patients need surgical treatment. the elderly are often complicated with many medical diseases and the perioperative risk is high, so minimally invasive surgery is a new direction for spinal surgeons to treat lsp. unilateral biportal endoscopy (ube) is a new spinal minimally invasive technique improved. the results of pilot studies showed that it had the advantages of less traumas, fewer complications, quicker recover，and the clinical and imaging outcome was remarkable. therefore, the present study aims to establish a multicenter, large sample, randomized controlled study to explore the technical advantages and surgical indications of this new technique in the treatment of lsp by comparing with the classical minimally invasive posterior spinal interbody fusion; (2) to compare the postoperative clinical and imaging results and analyze the surgical complications and preventive measures; (3) to establish two-year follow-up to further quantify the clinical and imaging outcome of ube. therefore, the present study will further verify and quantify the safety and effectiveness of the ube in the treatment of lsp on the basis of previous studies, and provide a new clinical approach for minimally invasive treatment of lsp.

Eligibility criteria:
inclusion criteria: * lumbar spondylolisthesis, * 40 yrs\<age\< 75yrs * fusion levels \<2 exclusion criteria: * greater than lenke-slivia classification iii * severe osteoporosis (t value \<2.5) * asa 》iv
prolene versus ethibond for cervical cerclage

Conditions: Cervical Incompetence

Summary: the purpose of the proposed study is to examine the relationship between cerclage suture material of ethibond and prolene and its effect on the vaginal microbiome in a prospective randomized control trial. ethibond is another commonly used suture material for performing cervical cerclage that shares some characteristics with previously studied suture materials. it is braided like the mersilene, but thinner like the monofilament prolene. the investigators will study whether ethibond causes the vaginal microbiome to be adversely affected like mersilene or whether there is a healthy microbiome like prolene. this study will allow the investigators to determine whether it is advisable to continue to use ethibond for cervical cerclage in clinical practice, or whether obstetricians should avoid its use as now done with mersilene.


Eligibility criteria:
inclusion criteria: * greater than18 years of age * singleton pregnancy * history of preterm delivery between 17 0/7 weeks - 33 4/7 weeks with painless cervical dilation or cervical insufficiency exclusion criteria: * younger than 18 years of age * multiple gestation * iatrogenic preterm delivery * pregnancies with fetal anomalies