Kornimate/medical-research-clean huggingface dataset:
efficacy of intermediate and high intensity regimens in patients with relapsed acute lymphoblastic leukemia

Conditions: Acute Lymphoblastic Leukemia

Summary: the aim of this study is to describe the survival and relapses of patients with diagnosis of acute lymphoblastic leukemia at two tertiary level hospitals in the metropolitan area of the valley of mexico

retrospective, observational study in patients with diagnosis of acute lymphoblastic leukemia, according to the criteria of the world health organization, from july, 2016, to october, 2020. the patients were cared for in the hematology department of the hospital general de mexico and in the hematology department of the hospital regional de alta especialidad ixtapaluca. relapse was considered in those cases with more than 5% of blasts in bone marrow and as relapse to the central nervous system with the presence of blasts in cerebrospinal fluid.

Eligibility criteria:
inclusion criteria: * patients with diagnosis of acute lymphoblastic leukemia according to the criteria of the world health organization. exclusion criteria: * age less than 15 years * age over 60 years

Keywords: survival leukemia relapse retrospective study
exercise as treatment of neck pain among helicopter pilots and crew members

Conditions: Neck Pain; Shoulder Pain

Summary: the aim of this project is to investigate, whether physical training, targeted neck and shoulder muscles, can reduce and prevent neck pain among military helicopter pilots and crewmembers.

military helicopter pilots and crewmembers is often burdened by work-related neck and shoulder pain. neck pain is a health challenge, that can reduce functional level, concentration and operational safety. physical exercise has shown good efficacy in reducing neck/shoulder pain in other occupational groups in previous studies. the royal danish air force and the university of southern denmark, wishes to examine whether specific physical exercise can prevent and reduce neck/shoulder pain within this occupational group. participants in this project will be randomly selected to either a physical exercise group or a reference group. * the physical exercise group will follow a training program targeted neck and shoulder muscles and train 1 hour per week (3 x 20 min) for 26 weeks. * the reference group will continue normal routines, including workout routines. they will later be offered the same training program as the physical exercise group provided that training has a positive effect.

Eligibility criteria:
inclusion criteria: * employed within the royal danish air force * helicopter pilot * crewmember (flight engineer, rescue swimmer or mission system operator) * flown within the past 6 months exclusion criteria: * grounded at time of inclusion * participated in a training intervention within the past 12 months

Keywords: pain, neck, exercise, pilots, crewmembers,
comparing mindfulness-based breath training and heart rate variability biofeedback for shoulder surgery patients in the postoperative pain.

Conditions: Pain, Postoperative; Shoulder Pain

Summary: although shoulder surgeries can effectively relieve pain intensity and restore shoulder function, some patients reported persistent post-operative pain at the 6-month post-surgery follow-up visit. this randomized study aims to determine the effectiveness of three different types of bio-psychosocial support to pre-operative shoulder surgery patients. this study will examine the differential effects of brief mindfulness-based breathing, heart rate variability biofeedback (hrv-bf), and cognitive behavioral pain psychoeducation for pre-operative patients.


Eligibility criteria:
inclusion criteria: shoulder pain patients with * (1) pain ≥3months and ≥3 days per week * (2) pain intensity ≥ 40 (vas scale from 0 no pain to 100 very painful) * (3) the surgical indication would be based on orthopedics opinions exclusion criteria: * history of shoulder surgery in the prior 3 years * osteoporotic vertebral fractures or rheumatologic diseases * chronic widespread pain syndromes (fibromyalgia or chronic fatigue syndrome) * neurological disease (i.e., stroke, parkinson's disease, etc..) * psychiatric disease (i.e., dementia, depression, schizophrenia, etc) * cancer * patients who practiced yoga, meditation, chi-qong, mindfulness, or deep breathing exercises more than three times per week

Keywords: shoulder pain postoperative pain mindfulness hrv biofeedback
effects of exercise training on patients with long covid-19

Conditions: Long COVID-19

Summary: effects of exercise training on patients with long covid-19, is a single-center, randomized, controlled trial designed to evaluate the effects of 4- week aerobic exercise administered to patients with long covid-19 symptoms. the main outcome is cardiopulmonary fitness and long covid-19 symptom improvement. quality of life, depression, anxiety, insomnia status and perceived stress will also be assessed before and after the exercise program.

long covid-19 symptoms are characterized by systemic deterioration of the entire body, leading to significant physiological and functional imbalances. common symptoms may be related to decreased short-term or long-term exercise capacity resulting from organ tissue damage, such as myocardial and pulmonary dysfunction. currently, even vaccines and medications cannot effectively address the long-term consequences of covid-19. exercise training has been proven to improve exercise capacity and quality of life during the recovery period for various chronic disease patients. a total of 24 patients will be included in the study. following informed consent and baseline testing, the participants will be randomized in a 1:1 fashion to receive a 4-week aerobic exercise training or attention control.the main objective is to assess the effects of a 4-week aerobic exercise training program on cardiopulmonary fitness and long covid-19 symptom improvement. secondary objectives include: to characterize baseline and intervention-related changes in quality of life, depression, anxiety, insomnia status and perceived stress status.

Eligibility criteria:
inclusion criteria: 1. 18-75 years old; 2. complicated with at least one of the following symptoms within 3 months after covid-19 infection, lasts for at least 2 months, and is not caused by other diseases: cough, fatigue, memory loss, concentration problems, palpitation easily or rapid heartbeat, chest tightness or chest pain, pain (head, limbs, lower back), slow thinking or reaction, eye discomfort or decreased vision, shortness of breath or difficulty breathing at rest, diarrhea, loss of taste or decreased taste, insomnia, hair loss, other new symptoms after covid-19 infection 3. tested positive for covid-19 quantitative reverse transcription-polymerase chain reaction (rt-pcr) or antigen kit and turned negative for at least 4 weeks before inclusion; 4. the patient understands and signs the informed consent form. exclusion criteria: 1. infected with covid-19 within one month 2. conditions that may be worsened by exercise, such as acute cardiac insufficiency, exercise asthma, epilepsy, etc. 3. physical disabilities caused by bone and joint or neuromuscular diseases, 4. complicated with other serious diseases (such as unstable angina, resting oxygen saturation \< 93%, untreated heart failure, uncontrolled arrhythmia, uncontrolled hypertension, uncontrolled type 2 diabetes), 5. women during pregnancy and lactation; 6. patients was assessed unsuitable for this study.

Keywords: long covid-19 exercise training cardiopulmonary fitness symptom improvement
severe intraocular infection

Conditions: Endophthalmitis

Summary: the host-immune reaction to infection is essential for the comprehension of the disease and the development of new therapies. the aim of the study is to describe intraocular cytokines network in aqueous humor using multiplex immunoassay, during severe intraocular infection.


Eligibility criteria:
inclusion criteria: * post-operative endophthalmitis * cataract exclusion criteria: * none

Keywords: endophthalmitis cytokines chemokines inflammation regulation
prospective cohort study on the efficacy of vagus nerve stimulation for children and adolescents with epilepsy(pvns-cae)

Conditions: Epileptic Encephalopathy

Summary: prospective cohort study on the long-term effectiveness and safety of pins vagus nerve stimulators for children and adolescent with refractory epilepsy.

epileptic encephalopathy is very common in children and adolescent with epilepsy, but there is no data in clinical studies.the aim of this study is to evaluate the efficacy of the long-term vagus nerve stimulation for children and adolescent with epilepsy

Eligibility criteria:
inclusion criteria: 1. age 4-18 2. diagnostic criteria for epilepsia brain disorders 3. having tried appropriate anti-epileptic drugs (aeds) more than 1 year and zt least 6 seizures per month 4. patients or his(her) families could understand this method and sign the informed consent 5. patients with good compliance and could complete postoperative follow-up exclusion criteria: 1. the vagus nerve lesion and damage 2. patients with progressive neurological diseases, cardiopulmonary anomaly, respiratory system diseases,digestive system diseases 3. patients'mental state is not stable， 4. patients with or anesthesia contraindications,such as long-term use of anticoagulation antiplatelet drugs etc. 5. patients have or need other implantable devices, such as pacemakers,defibrillators, cochlear and spinal nerve root stimulator. 6. patients due to their own reasons for the need for nuclear magnetic resonance imaging in the future clinical trials 7. patients have participated in other clinical trials.

Keywords: children and adolescents prospective cohort study vagus nerve stimulation pins
a study of neorecormon (epoetin beta), cellcept (mycophenolate mofetil) and prednisone in patients with low or intermediate myelodysplastic syndromes.

Conditions: Myelodysplastic Syndromes

Summary: this single arm study will evaluate the efficacy and safety of a combination of neorecormon, cellcept and prednisone in patients with low or moderate risk myelodysplastic syndromes (mds). in the first phase of the study, patients will receive cellcept (1g p.o. twice daily) plus prednisone. after 3 months, if patients have not responded to treatment, neorecormon (30000 iu/week, s.c.) will be added to the treatment regimen. if there is no response to neorecormon after 6 weeks, the dose will be increased to 60000 iu/week. the anticipated time on study treatment is 3-12 months, and the target sample size is \<100 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, \>=18 years of age; * diagnosis of mds, according to international prognostic scoring system (ipss) criteria; * low or intermediate risk, who are not candidates for treatment with growth factors, or who have not responded to these treatments. exclusion criteria: * previous treatment with cellcept, or any erythropoietin-stimulating drug; * diagnosis of proliferative chronic myelomonocytic leukemia; * prior or concomitant malignancies other than mds, with the exception of basocellular, spinocellular or adequately treated in situ cervical cancer, in the past 3 years; * biological antitumor and myelosuppressive treatment within 28 days before start of study; * bone marrow precursor cell transplantation previous to study.
impact of low-dose epidural analgesia on labour progression in low-risk women

Conditions: Epidural Analgesia, Obstetric

Summary: aim of the study was to analyse data on cervical dilation and fetal descent patterns in low-risk women, who did or did not receive intermittent low-dose epidural analgesia (ea), and who had either a vaginal or a caesarean delivery. therefore, we conducted a retrospective analysis, retrieving data from october 1st 2008 to october 31st 2018. we selected 6030 women categorized as robson group 1, divided into four groups according to the mode of delivery (vaginal or caesarean) and the presence of ea: * vaginal delivery with ea (vd-e) * vaginal delivery without ea (vd-n) * caesarean delivery with ea (cd-e) * caesarean delivery without ea (cd-n)


Eligibility criteria:
inclusion criteria: * robson class 1 (nulliparous, single, cephalic full-term pregnancy with spontaneous labour) * maternal age between 18 and 40 years * neonatal weight between 2500 and 4000 grams * cervical dilation \<7 cm at admission in the delivery suite exclusion criteria: * minimal duration of labour \< 3 hours (from admission to the delivery suite to delivery)

Keywords: labor epidural analgesia cesarean section instrumental delivery neonatal well-being
surgical pa-laa shunting: a feasibility study

Conditions: LAA Thrombus Prevention

Summary: atrial fibrillation is common and increases the risk of stroke. traditionally patients are treated with blood thinning medications or at the time of surgery the part of the heart where blood clots form is cut out. surgically cutting out the left atrial appendage can be difficult and complications can occur. an alternative strategy is to create a tunnel to increase blood flow and wash out the part of the heart where clots form. this strategy has not been previously studied. the purpose of this study is to determine if creating a tunnel to increase blood flow is feasible and safe.

the goal is to understand the potential avenues to increase left atrial appendage (laa) flow in patients with atrial fibrillation (af) to minimize systemic embolization risk. flow modeling demonstrates that the anatomy of the laa results in decreased velocities in the laa apex. introduction of a 3-4mm shunt in the apex can result in increased velocity, less stasis and a lower propensity for thrombus formation. small (\<8mm) inter-chamber shunts can exist in humans with no long term hemodynamic consequences in otherwise structurally normal hearts - making a strategy of pulmonary artery (pa) to laa shunt an attractive potential therapy given anatomic proximity and gradient differential between the cardiac chambers. this will be a 5 patient first-in-human feasibility study. the population will include patients undergoing cabg or other cardiovascular surgery with af and a chads2 score \>1 in whom the treating team deems traditional therapy with anticoagulants is prohibitive or ineffective (dialysis or egfr preoperatively \<15, previous bleeding with non-reversible pathology, clinically deemed contraindicated to oral anticoagulant). the intervention will be pa-laa shunt creation at the time of surgery. as this is a single arm study there will be no comparison group.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years undergoing cv surgery * history of af with a chads2 score \>1 * relative contraindication to oac as determined by the heart team 1. dialysis or preoperative egfr of \<15 2. bleeding on doac/coumadin with non-reversible pathology 3. other medical condition that makes the patient ineligible for oac * anatomic proximity of laa and pa on preoperative ct scan suitable for shunt creation exclusion criteria: * lvef \<40% * history of vte - either dvt or pe * resting baseline preoperative o2 sats \<98% * inability of the patient to provide written informed consent * greater than moderate valvular heart disease which is not to be addressed during surgical intervention * documented mpa to pcwp \<5mmhg

Keywords: shunting
the effect of the transversus abdominis plane (tap) block on the minimal laparotomy : a randomized controlled trial

Conditions: Colon Cancer

Summary: transversus abdominis plane block (tap block) is a new regional block for abdominal wall.it had been reported the effect of post-operative pain control in minor abdominal surgery, such as inguinal hernia repair and appendectomy. on the other hand, because of the accurate of the pre-operative images, the minimal laparotomy for colon cancer was accomplished. thus, the purpose of this study is to investigate the effect, such as analgesic effect, hemodynamic stability, and post-operative morphine consumption, of tap block in minimal laparotomy.

outcome measures: * hemodynamic parameters (mean artery pressure, heart rate): recorded at time points of before induction of general anesthesia (baseline), after tracheal intubation immediately, after surgery started 1, 2, 3, 4, 5, 10, 15, 20, 25, and 30 min; then recorded them every 10 mins. * post-operative morphine consumption: recorded morphine consumption at the time intervals of post-operative 0\~6 h, 6\~12 h, 12\~24 h, 24\~36 h, and 36\~48 h ,respectively. the total amount of morphine consumption was also counted.

Eligibility criteria:
inclusion criteria: * anesthesiologists physical status i-iii, ≧ 18 years of age, and needed double-lumen endotracheal tube (dlt) for thoracic surger exclusion criteria: * increased risk for regurgitation and pulmonary aspiration, history of gastroesophageal reflux, and pregnancy * a tracheostomy or prolonged ventilation on icu was planned, patients were also excluded

Keywords: minimal laparotomy tap block morphine consumption post-operative analgesia
a randomized, open-label, multi-center, phase iii study of orelabrutinib in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (r-chop) vs. r-chop alone in patients with treatment-naїve mantle cell lymphoma

Conditions: Treatment-naїve Mantle Cell Lymphoma

Summary: to evaluate the efficacy of orelabrutinib combined with r-chop vs. r-chop alone in the treatment of treatment-naїve mantle cell lymphoma.


Eligibility criteria:
inclusion criteria: 1. 65 \< age \<80, or 60 ≤ age ≤65 and is ineligible for autologous stem cell transplantation as assessed by the investigator 2. histopathological confirmed mcl and either expression of cyclin d1 or t (11;14) chromosomal translocation (in association with cd20). the verification will be based on central review of the local pathology report. 3. no previous systemic treatment for mcl. 4. ecog physical strength score is 0-2. 5. expected survival time \>6 months. 6. voluntary written informed consent prior to screening. exclusion criteria: 1. uncontrolled or significant cardiovascular diseases 2. history of stroke or intracranial hemorrhage within 6 months before first administration of study treatment. 3. any mental or cognitive impairments which may limit the subject 's understanding and execution of informed consent as well as study compliance; 4. pregnant or breastfeeding women and those who do not agree to take contraceptive measures. 5. conditions in which a potentially life-threatening illness or severe organ dysfunction is not considered appropriate by the investigator. note: other protocol defined inclusion/exclusion criteria may apply.
comparison of intrapleural urokinase and video-assisted thorascopic surgery in the treatment of parapneumonic pleural effusion in children

Conditions: Empyema, Pleural

Summary: despite the improvement in the technology available for diagnosing and treating empyema, the management of empyema in children remains controversial. the purpose of this study is to compare the efficacy and safety of two common technical approach used for pleural effusion drainage in the treatment of childhood empyema.


Eligibility criteria:
inclusion criteria: * patients under the age of 17 * pleural fluid depth of at least 15mm, confirmed by ultrasound * at least one of the following severity criteria : 1. fever continuing 48h after starting correct antibiotherapy 2. respiratory distress 3. mediastinal displacement on the chest x-ray exclusion criteria: * previous drainage by either video-assisted thoracoscopic or pleural drainage by percutaneous drain associated with urokinase- congenital pulmonary disorders with lung function impairment * congenital pulmonary disorders with lung function impairment * chronic pulmonary disease associated with lung function impairment * hemodynamic instability * congenital immunodeficiency disease * secondary immune deficiency induced * hemostasis disorder (contraindication of thrombolytic therapy) * pregnancy or breastfeeding patient
ibuprofen sodium tension headache study

Conditions: Pain

Summary: this study will compare the ability of a single-dose of a novel ibuprofen formulation to relieve pain compared to placebo and standard ibuprofen in the treatment of tension-type headache


Eligibility criteria:
inclusion criteria: * males and females at least 18 years to 65 years of age * a diagnosis of an episodic tension-type headache, as defined by the international headache society exclusion criteria: * pregnancy or breast-feeding * alcohol or substance abuse * any serious medical or psychiatric disorder

Keywords: headache
a study of multiple dosing regimens of iv conivaptan in subjects with euvolemic or hypervolemic hyponatremia

Conditions: Hyponatremia; Euvolemia; Hypervolemia

Summary: the study will evaluate the effectiveness and safety of multiple dosing regimens of iv conivaptan in subjects with euvolemic or hypervolemic hyponatremia


Eligibility criteria:
inclusion criteria: * subject has a serum sodium value between 115 and 133 meq/l * subject is euvolemic or hypervolemic exclusion criteria: * clinical evidence of volume depletion or dehydration * uncontrolled brady- or tachyarrhythmias requiring emergent pacemaker placement or treatment

Keywords: hyponatremia euvolemia hypervolemia conivaptan vaprisol® ym087
evaluate the effectiveness of the vivaer arc stylus for nasal breathing

Conditions: Nasal Obstruction, Bilateral

Summary: a prospective, multicenter, non-randomized study of the aerin medical vivaer arc stylus for nasal airway obstruction

the primary objective of this post-market study is to continue to evaluate the effectiveness of the vivaer® arc stylus for treating the nasal valve area to improve symptoms in those diagnosed with nasal airway obstruction using validated questionaires.

Eligibility criteria:
inclusion criteria: eligible subject will meet all the following: * 1. age 18 or older 2. willing and able to provide informed consent 3. willing and able to comply with the study protocol 4. seeking treatment for nasal obstruction 5. nose score of ≥ 60 at baseline 6. nasal valve is a primary or significant contributor to the subject's nasal obstruction as determined by the study investigator (based on clinical presentation, physical examination, nasal endoscopy, etc.) and the subject has a positive response to any of the following temporary measures (based on patient history or office exam): * use of external nasal dilator strips (e.g., breathe right strips) * q-tip test (manual intranasal lateralization) * use of nasal stents * cottle maneuver (manual lateral retraction of the cheek) exclusion criteria: eligible subjects will not meet any of the following: 1. prior surgical treatment of the nasal valve 2. rhinoplasty, septoplasty, inferior turbinate reduction or other surgical nasal procedures within the past six months 3. medical conditions which in the opinion of the treating physician would predispose the subject to poor wound healing or increased surgical risk. 4. known or suspected to be pregnant or is lactating. 5. any adjunctive surgical nasal procedure planned on the same day or within 24 months after the vivaer procedure. 6. current participation in any study or participation in any study less than 6 weeks before study date 1. -

Keywords: nasal obstruction nasal valve stenosis nasal valve pathology
outcome of idiopathic macular hole

Conditions: Idiopathic Macular Hole

Summary: the purpose of this study is to evaluate the role of cataract surgery and cystoid macular edema (cme) on reopening of idiopathic macular holes (imh).


Eligibility criteria:
inclusion criteria: * patients with with stage 2, 3, or 4 idiopathic macular hole after successful idiopathic macular hole repair exclusion criteria: * all patients without stage 2, 3, or 4 idiopathic macular hole repair

Keywords: idiopathic macular hole cataract edema reopening