Kornimate/medical-research-clean huggingface dataset:
long term follow-up of knee pain patients accompanying meniscus tear

Conditions: Meniscus Tear

Summary: the purpose of this study is to reveal the effectiveness and satisfaction of integrative korean medicine for meniscus tear by observation patients treated with integrative korean medicine. this study is a prospective observational study. the subjects for study are patients diagnosed with meniscus tear and who have been admitted to gangnam jaseng hospital of korean medicine, bucheon jaseng hospital of korean medicine, daejeon jaseng hospital of korean medicine and haeundae jaseng hospital of korean medicine for 2015.06-2020.06.

medical records of selected patients will be analyzed, and telephone surveys will be conducted for each patient. the survey questions are numeric rating scale (nrs), western ontario and mcmasters universities(womac) osteoarthritis index, quality of life, and patient global impression of change (pgic), etc.

Eligibility criteria:
inclusion criteria: 1. patients who have been diagnosed with "meniscus tear" in the emr imaging (x-ray or mri or ct) of hospitalization 2. patients who have been hospitalized by knee pain 3. a person who voluntarily orally agrees to participate in a clinical trial exclusion criteria: 1. if the hospitalization period is less than 3 days, 2. if there are other chronic diseases that may interfere with the treatment effect or interpretation of the results: cardiovascular disease, kidney disease, diabetic neuropathy, dementia, epilepsy, etc. 3. if the cause of pain is caused by a soft tissue disease other than knee joint: tumor, fibromyalgia, rheumatoid arthritis, gout, etc. 4. patients within 3 months of surgery on the hip joint 5. if there is a fracture of the joint in the image finding 6. if researchers judge that it is inappropriate to participate in the study; 7. if you do not agree to participate in the study; 8. minors
efficacy study of fine needle technique on calcific tendinitis

Conditions: Tendinitis

Summary: background: calcific tendinitis of the rotator cuff may cause chronic pain at the shoulder. sometimes the pain can lead to a serious impairment in the daily life. one of the most efficient treatments is percutaneous needle aspiration using ultrasound guidance. this treatment includes identification the tendonitis with us or screening , local anesthesia and then puncturing the calcium in the rotator cuff many times. the treatment is short 5-10 minutes, relatively cheap ,safe and usually with good outcomes. however in the literature there is a lack of controlled prospective trials. our goal is to set a study that will evaluate this treatment between two groups: 1. puncturing the calcium in the rotator cuff 15 times (the experiment group) 2. puncturing the calcium in the rotator cuff twice (the controlled group)


Eligibility criteria:
inclusion criteria: 1. age 18 and above. 2. 6 months of pain in the shoulder. 3. positive imping and sensitivity on sst. 4. calcification above 1 cm in one of the dimensions by us or aray of the shoulder. 5. completed conservative treatment: physiotherapy or analgesics. exclusion criteria: 1. diabetes, nephrological diseases 2. rc tear according to us. 3. prior operation in this shoulder 4. steroids injection in the last three months. 5. a patient that is in the absorption phase of the tendinitis 6. pregnancy 7. coagulation system impairments

Keywords: calcific tendinitis
a combined training program for veterans with amnestic mild cognitive impairment

Conditions: Amnestic Mild Cognitive Impairment

Summary: the purpose of this study is examine the efficacy of a combination physical exercise and cognitive training program on improving memory in older veterans with amnestic mild cognitive impairment.


Eligibility criteria:
inclusion criteria: * diagnosis of amnestic mild cognitive impairment * available informant * visual and auditory acuity to allow neuropsychological testing * willingness to participate in exercise training + cognitive training for 8 months * approval of primary provider to participate in exercise trial exclusion criteria: * current severe psychiatric disorder * diagnosis of dementia * history of neurological or system illness affecting cns function * acute illness or unstable chronic illness * current severe cardiac disease * inability to exercise consistently because of orthopedic or musculoskeletal problems * morbid obesity * inability to read, verbalize understanding and voluntarily sign the informed consent

Keywords: mild cognitive impairment aging
medium chain triglycerides and aerobic exercise on ketone production in women with or without prediabetes

Conditions: Prediabetic State

Summary: the aim of this study is to compare the effect on ketone production of dietary an mct supplement combined or not with physical exercise in two groups of women (n=10/group), healthy adults and patients with prediabetes. after an evaluation of the metabolism (a 4-hour visit with multiple blood samples) at the beginning of the study, all the participants are taken for one-week the mct supplement alone follow by a one-week period of taking the mct supplement in combination with physical exercise. at the end of each period of time, the 4-hour visit for the evaluation of the metabolism is repeated.


Eligibility criteria:
inclusion criteria: * healthy women group: fasting blood glucose \< 6.1 mmol/l and hba1c \< 6.0 %. * women with prediabetes: fasting blood glucose between 6.1 and 6.9 mmol/l and hba1c between 6.0 and 6.4 % exclusion criteria: * structured physical activity (more than 2 times per week) * inability to practice physical exercise * diabetes (fasting glucose ≥ 7.0mmol/l or hba1c ≥ 6.5%) * uncontrolled dyslipidemia or hypertension * use of medications known to affect the metabolism of lipids and carbohydrates (steroids, beta-blockers, diuretics, insulin sensitizers, etc.) * severe infections or inflammations
effectiveness of radial extracorporeal shock wave therapy and supervised exercises in lateral epicondylitis

Conditions: Lateral Epicondylitis

Summary: no consensus has yet been built on the treatment of lateral epicondylitis (le) due to the lack of evidence. although conflicting results are present, radial extracorporeal shock wave therapy (reswt) has increasingly been used in the treatment of tendinopathy

eswt and exercise have beneficial effects on the management of tendinopathies owing to their various mechanisms that showed therapeutic efficacy. owing to its positive outcomes, extracorporeal shock wave therapy (eswt) has recently been used in the treatment of musculoskeletal system diseases such as plantar fasciitis, achilles tendinopathy, calcific rotator cuff tendinopathies, and patellar tendinopathy

Eligibility criteria:
inclusion criteria: * the diagnosis of le was made in the clinical examination, and the diagnosis was confirmed with the southampton diagnostic criteria of "the presence of epicondyle pain, and epicondyle pain and tenderness on resisted extension of the wrist. * patients with symptoms lasting longer than 3 months * with average pain in the previous week detected as 3 or above on a 10-cm visual analogue scale (vas) * who were aged over 18 years exclusion criteria: * pain in the proximal part of the affected extremity (e.g. shoulder pain, neck pain) * abnormal neurogenic symptoms (e.g. radicular pain, numbness) on the affected extremity * presence of posterior interosseous nerve entrapment * congenital or acquired upper extremity deformities that might affect grip strength * systemic musculoskeletal system or neurologic disorders * systemic rheumatologic disease or systemic infection * presence of malignancy, coagulation disorders, and anticoagulant use * inserted cardiac pacemaker * history of surgical treatment on the elbow of the affected extremity * pregnancy. * patients who were administered other treatments such as physical therapy or steroid injections in the last 3 months
the effect of intravenous acetaminophen on post-operative pain after craniotomy

Conditions: Pain

Summary: the purpose of the study is to determine the efficacy of iv acetaminophen when administered to neurosurgical patients at the beginning and end of their surgery. if the result is improved pain control with less opioid consumption postoperatively, then those patients may also experience less opioid related side effects such as nausea/vomiting, pruritus, and sedation. while numerous other studies have failed to show a benefit of iv acetaminophen after neurosurgical procedures, we are studying the administration of 1 g in two doses over the course of the operation.


Eligibility criteria:
inclusion criteria: * patients with a diagnosis of bilateral moyamoya disease scheduled for bilateral external-carotid to internal-carotid bypass surgery to be done in two stages. exclusion criteria: * allergy or history of reaction to acetaminophen. patients with liver disease. anyone not able to provide informed consent.
surgical ablation of long-standing persistent af during cabg

Conditions: Coronary Artery Disease

Summary: purpose. comparison of outcomes in patients underwent cabg combined with left atrial and biatrial radiofrequency ablation of long-standing persistent atrial fibrillation. hypothesis of the study - patients with long-standing persistent atrial fibrillation and coronary artery disease after cabg in combination with biatrial rfa have a better outcomes for the freedom of af compared with patients undergoing left atrial rfa during cabg.

this is a single blinded prospective randomized study involving 116 patients with long-standing persistent af and coronary artery disease. 116 patients are required to have a 80% chance of detecting, as significant at the 5% level, an increase in the primary outcome (freedom fro af) measure by 12% in the biatrial group over left atrial group. patients are divided into two groups, group i - biatrial + cabg (58 patients), and group ii - left atrial + cabg (58 patients). randomization is conducted by using accidental sampling before operation. the blinding process is applied to a patient, who is informed about received coronary artery bypass grafting, but don't know about kind of surgical ablation. subcutaneous cardiac monitor is implanted to all patients for cardiac rhythm monitoring.

Eligibility criteria:
inclusion criteria: * american college of cardiology (acc)/ american heart association (aha) indications for cabg * at least 2 ecg-verified (12-channel ecg, holter telemetry) long-term persistent af within last 12 months * the patient's consent to participate in the study exclusion criteria: * intolerance of antiarrhythmic drugs * heart valve disease requiring invasive treatment * left atria more than 6.5 cm * prior cardiac surgery * active pacemaker treatment * active anti-arrhythmic treatment (aad) class i and iii * contraindication to oral anticoagulant/heparin treatment * ejection fraction less than 30 % (ef \< 30 %) assessed by transthoracic echocardiography

Keywords: ablation, cabg long-standing persistent atrial fibrillation
nivestim™ in treatment of malignant diseases

Conditions: Solid Tumour; Malignant Haematological Tumour; Primary or Secondary Prophylactic Treatment

Summary: the purpose of this study is to observe the tolerability, safety and efficacy of preventative treatment using nivestim™ in patients receiving cytotoxic chemotherapy for cancer.

this is a non-interventional, descriptive, national, multi-site, longitudinal and prospective observational study with in-patients adults or minors undergoing cytotoxic chemotherapy, being treated prophylactically with nivestim™ in order to reduce the duration of neutropenia and to reduce the incidence of chemotherapy-induced febrile neutropenia (fn).

Eligibility criteria:
inclusion criteria: * no age limit * declaration of informed consent signed by patient or legal guardian * patients with a solid tumour or with a malignant haematological tumour * patients for whom cytotoxic chemotherapy is planned, irrespective of cycle * patients who are due to undergo, or who should undergo, (primary or secondary) prophylactic treatment using nivestim™, either to shorten the duration of a neutropenia or to prevent the occurrence of chemotherapy induced febrile neutropenia (fn). exclusion criteria: * patients with chronic myeloid leukaemia (cml) or with myelodysplastic syndrome (mds) * patients who are hypersensitive to the active substance or to one of the excipients of nivestim™ * patients not undergoing chemotherapy * patients being treated curatively with granulocyte-colony stimulating factor (g-csf)

Keywords: cytotoxic chemotherapy g-csf solid tumour malignant haematological tumour
striving to quit: first breath

Conditions: Smoking Cessation; Smoking; Nicotine Dependence

Summary: this study is designed to test the hypotheses that incentives can increase both participation in smoking cessation treatment and resulting cessation rates, when they are offered to medicaid badgercare plus pregnant smokers.

aim 1: to determine the extent to which contingent financial "treatment incentives" (i.e., incentives for biochemical verification visits, treatment engagement, and abstinence) versus "attendance incentives" (i.e., incentives for only attending the biochemical verification visits), increase rates of prenatal and postnatal smoking abstinence. participants will be badgercare plus members who are recruited into the first breath program while pregnant. aim 2: to determine the extent to which treatment incentives, versus attendance incentives, increase rates of engagement in first breath smoking cessation intervention when offered to pregnant and postpartum badgercare plus members. aim 3: to determine the cost-effectiveness and reach of the first breath intervention delivered to pregnant and postpartum smokers when it is paired with treatment incentives and when paired with only attendance incentives. aim 4: to determine if the first breath intervention with treatment incentives, in comparison to that intervention with only attendance incentives, produces significantly greater benefits in pregnant and postpartum women with regards to nonsmoking health outcomes: i.e., reduced depression, increased levels of breast feeding, and greater perceived support. aim 5: to identify moderating and mediating effects of treatment incentives when offered in the context of the first breath intervention delivered to pregnant and postpartum women.

Eligibility criteria:
inclusion criteria: * pregnant women * enrollment in wisconsin medicaid (badgercare plus or medicaid ssi) * resides in study area * member of participating medicaid hmos * not involved in any other stop smoking research studies * 18 or older * english speaking * smoked daily (at least one cigarette each day for at least one week) at some time within the last 6 months * willingness to quit smoking, cut down, or stay quit * willing to complete study visits and phone calls * willing to provide updates in contact information exclusion criteria: * not enrolled in wisconsin medicaid (badgercare plus or medicaid ssi) * not enrolled in study area * not a member of participating medicaid hmos * not pregnant or enrolled in first breath * less than 18 years of age * non-english speaking * does not smoke daily (at least one cigarette each day for at least one week) at least some time within the last 6 months * not willing to complete study procedures and assessments or provide updated contact information
a study of the quality of life in adults with crohn's disease with complex perianal fistulas

Conditions: Crohn Disease; Rectal Fistula

Summary: the main aim of the study is to assess the quality of life of people with crohn's disease after treatment for complex perianal fistulas (cpf) in a standard clinic setting. study doctors will review the participants' medical records in the last 3 years. participants will also be asked to visit the clinic once to complete 1 questionnaire on their quality of life.

this is a national, observational, cross-sectional study. the study will assess the general qol among cd participants with cpfs in the portuguese routine clinical practice. this study will enroll approximately 80 participants. all participants will be enrolled in one observational cohort. the data will be collected retrospectively, from the medical records, on healthcare resource utilization and on the pharmacological and surgical treatments used for the management of cpfs in the three years prior to the inclusion visit. this multi-center trial will be conducted in portugal. the overall duration of this study is approximately 8 months.

Eligibility criteria:
inclusion criteria: 1. diagnosed with cd. 2. presence of cpf(s), defined as \>=1 of the following criteria: * high intersphincteric, high transsphincteric, extrasphincteric, or suprasphincteric location; * \>=2 external openings; * associated collections. 3. attending routine gastroenterology appointments at the participating hospitals. exclusion criteria: 1. diagnosed with ulcerative colitis or indeterminate inflammatory bowel disease (ibd). 2. with non-complex fistulas or with fistulas types other than perianal (example, rectovaginal).

Keywords: drug therapy
molecular characteristics and prevalence of viral hepatitis e in human tissue and cell donors

Conditions: Hepatitis E

Summary: in this study, the researchers want to focus on the prevalence of anti-hev antibodies by a new generation test, direct detection of hev rna, and its genotypic analysis in a group of human tissue and cell donors.

at the department of laboratory medicine of the faculty of medicine of the faculty of medicine of the national university of health sciences, human tissue and cells from donors will be examined for the assessment of health eligibility and donor selection according to decree no. 422/2008 coll. according to the current legislation, the determination of igg and igm antibodies against hev or the hev rna method is not part of the standard examination of human tissue and cell donors for the assessment of their health eligibility.

Eligibility criteria:
inclusion criteria: - patients indicated for organ or cell donation exclusion criteria: - none

Keywords: hepatitis e organ donor cell donor hev rna
long term safety of 125 mg per day of oral azimilide in patients with implantable cardioverter defibrillator (icds)

Conditions: Arrhythmias

Summary: this is an open-label, multi-center, long-term, (open-ended) safety study with 125 mg per day of azimilide in patients who completed protocol 2000098.


Eligibility criteria:
inclusion criteria: * patients who completed at least 12 months on study 2000098 before inclusion in this study exclusion criteria: * breast feeding or plan to become pregnant * used ticlopidine * were taking class i or other class iii drugs
treatment of early stage renal failure with active vitamin d or a phosphate binder.

Conditions: Kidney Failure

Summary: patients with reduced renal function normally develop hyperparathyroidism, which in turn is associated with increased cardiovascular risk and de-calcification. hyperparathyroidism may be enhanced by an increased level of fgf23 which is often seen in the early stage of renal failure. this pilot study will investigate the fgf23-lowering effect of early initiation of treatment with a phosphate binder versus active vitamin d in an open crossover design.


Eligibility criteria:
inclusion criteria: * renal failure stage 3b * 25(oh)vitamin d level above 50 nmol/l * age over 18 years * written consent exclusion criteria: * major surgery during the previous 6 months * myocardial infarct during the previous 6 months * unstable heart failure * ongoing treatment for any malignancy * history of frequent infections * pregnancy * ongoing treatment with steroids, lithium or biphosphonates

Keywords: renal failure stage 3b
rapid molecular organism identification and mixed flora antibiotic resistance profiling (mixar) prospective study

Conditions: Urinary Tract Infections; Prostatitis; Interstitial Cystitis

Summary: in this protocol, investigators are examining the ability for a novel multiplex pcr assay with mixed floral antibiotic resistance profiling is safe and increases effective treatment for urinary tract infections in a urology clinic over traditional culture methods alone and decreases retreatment rates in this population.

the novel multiplex real-time pcr assay with mixed floral antibiotic resistance profiling offers a higher degree of sensitivity and specificity than conventional culture methods in the identification of uti pathogens as determined by the previous prospective comparison study. additionally, conventional methods are often inadequate in the case of polymicrobial infections. more accurate and timely pathogen identification allows for prompt and more targeted treatment with less reliance on empiric therapy and decreased rates of antibiotic therapy changes and retreatment. this leads to more favorable patient outcomes and decreases the development of resistant organisms.

Eligibility criteria:
inclusion criteria: * • patient informed consent form completed * male and female subjects may participate with no predetermined quotas or ratios for gender participation. * all patients must be ≥60 years old. for patients presenting with a diagnosis of interstitial cystitis, patients may be of any age. * patients must be presenting for treatment of acute uti, complicated uti, persistent uti, or recurrent uti's. * including prostatitis, pyelonephritis, and/or interstitial cystitis. * data pertaining to the times at which the specimen samples are collected and stabilized needs to be documented. * specimen samples obtained need to have a sufficient volume necessary to perform a urine culture and guidance 4.0. exclusion criteria: * • do not provide written informed consent with hipaa authorization form. * taking antibiotics for any reason other than uti at the time of enrollment * patients with chronic (\> 10 days) indwelling catheters * self-catheterized patients * patients with neobladders

Keywords: uti ic
a 3d printed assistive technology intervention

Conditions: Chronic Disease

Summary: the purpose of this study is to understand the feasibility of using a 3d printer to create tailored assistive technology rehabilitation devices. specifically, we are investigating if a tailored 3d printed pillbox is safe, acceptable, and effective compared to an off-the-shelf generic pillbox. in this study, approximately 20 people with chronic health conditions who use pillboxes will describe their satisfaction and medication adherence with their current pillbox using a series of surveys and interviews. then they will partake in an interview about their pillbox, medications, and routines. based on the interview, the research team will 3d print a new pillbox tailored to the participant's preferences, abilities, and medication regimen. then the participant will use the pillbox for 2-8 weeks. at the end, the participant will answer the same questions describing their satisfaction and medication adherence with the new pillbox using a series of surveys and interviews. this research will reveal important knowledge about the potential of 3d printing in the clinic and effectiveness of customized assistive technology.


Eligibility criteria:
inclusion criteria: * english-speaking * adults (ages 18+ years) * use a pillbox at least weekly * prescribed 2+ medications * willing to try a new 3d printed pillbox exclusion criteria: * have significant cognitive impairment evidenced by a score of 10+ on the short blessed test * unable to meet with the research team in person and by phone

Keywords: assistive technology 3 dimensional printing self-management