Kornimate/medical-research-clean huggingface dataset:
reanimation of shoulder external rotation via neurotization

Conditions: Nerve Transfer

Summary: measurement of clinical outcome after nerve transfer in deficiency of shoulder external rotation in children with obpp.

brachial plexus birth injuries (bpbi) occur in 1-2 per 1,000 live births, often resulting from traction on the shoulder during delivery (1). right-sided injuries are more common due to fetal positioning.(2) bpbi presentations vary, with upper trunk injuries (erb's palsy) being most frequent, accounting for 45% of cases.(3) these injuries can impair shoulder abduction, external rotation, and arm function ,he can't flex the elbow to partially reache the hand to the mouth (the trumpet sign) .due to suprascapular nerve (ssn) damage, which is prone to stretching due to its fixed attachments.(4) erb's palsy affects muscles like the deltoid and biceps, supraspinatus and infraspinatus.(5) . assessments include testing hand sensation and noting color or trophic changes. without ssn reconstruction, secondary glenohumeral complications often arise, necessitating surgical interventions like tendon transfers, joint reductions, or osteotomies.(6) nerve transfer, such as spinal accessory nerve (san) fascicles to the ssn, has shown superior outcomes for restoring shoulder function. the san, a pure motor nerve, is well-suited for direct coaptation without interposition grafts.(7). surgical approaches include anterior and posterior methods, each with unique benefits. for instance, the anterior approach allows simultaneous brachial plexus exploration and facilitates nerve repair.(8) , while posterior approach prevents double crush phenomenon.(9) despite most children recovering spontaneously, 20-30% experience residual deficits (10). techniques like tension-free san-to-ssn repair aim to improve outcomes. this study evaluates the efficacy of san transfers in restoring shoulder stability, abduction, and external rotation in bpbi patients.(11)

Eligibility criteria:
inclusion criteria: * children within 1.5 - 3 years . * no previous surgery * full passive rom * presented with trumpet sign exclusion criteria: * age \ 3 years * previous surgery in the shoulder * stiff shoulder. * total obpp * traumatic bpi * follow up \<1 year.

Keywords: nerve transfer
checklists resuscitation emergency department

Conditions: Shortness of Breath; Chest Pain; Abdominal Pain; Altered Mental Status; Syncope; Seizures; Vertigo; Trauma; Allergic Reaction; Fever; Cardiac Arrest; Asthma Acute; COPD Exacerbation Acute; Pneumonia; Pulmonary Edema - Acute; Bradycardia; Tachycardia; Shock; Burns; Poisoning; Diabetic Ketoacidosis; Hyperglycemic Hyperosmolar Nonketotic Syndrome

Summary: the study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.

simulation-based studies indicate that crisis checklist use improves management of patients with critical conditions in the emergency department (ed). this six-month-long study prospectively evaluates a digital emergency manual-a collection of crisis checklists and fact sheets-during the management of priority 1 patients in the skåne university hospital at lund's ed.

Eligibility criteria:
inclusion criteria: * consecutive priority 1 patients managed in the resuscitation room of skåne university hospital at lund's emergency department exclusion criteria: * none
examination of the anti-inflammatory and insulin sensitizing properties of doxycycline in humans

Conditions: Type 2 Diabetes; Obesity

Summary: obesity is a heightened state of inflammation in which production of cytokines and matrix metalloproteinases (mmps) result in loss of function of insulin receptors and insulin resistance. doxycycline (dox) is a potent mmp inhibitor. we hypothesize that dox will enhance insulin sensitivity and decreases inflammation in obese participants with type 2 diabetes (dm2).

design and setting: 84 day (d84), double-blind, randomized, placebo (pl)-controlled clinical trial conducted in an academic tertiary care center. patients: non-dm2 controls (n=15); participants with dm2 receiving pl (n=13) or dox (n=11). interventions: all participants were evaluated at day 1 (d1); those with dm2 were also evaluated at d84 after dox 100mg twice daily or pl.

Eligibility criteria:
inclusion criteria: * ambulatory, medically stable, able to give informed consent, and comply with the protocol. * obesity with bmi \>30 kg/m2. * dm2 for less than 10 years. * 7.5% \< ha1c \< 10% * taking insulin and/or oral medications (biguanide, sulfonlylurea, etc.) exclusion criteria: * mental states that would preclude complete understanding of the protocol and compliance. * chronic illness such as renal failure (with creatinine clearance \<80 ml/min for specific aim 2). * women of child-bearing age because of the potential hazard to the fetus (doxycycline may cause permanent discoloration of the teeth and deposition in bone inhibiting growth) and because doxycycline may render oral contraceptives less effective. * nursing mothers. * allergy to tetracyclines. * subjects taking the following drugs: penicillin or it's derivatives, anticoagulant therapy, antacids containing aluminum, calcium, or magnesium, iron-containing preparations, bismuth subsalicylate, barbiturates, carbamazepine, phenytoin or methoxyflurane, thiazolidinediones (tzd)

Keywords: doxycycline insulin resistance obesity inflammation
fractional flow reserve-guided provisional side branch intervention

Conditions: Coronary Artery Disease

Summary: study purpose: to evaluate fractional flow reserve-guided side branch intervention strategy method: provisional side branch intervention if jailed side branch ffr\<0.75

patients with de novo, coronary bifurcation lesions with jailed side branches after successful drug-eluting stent implantation at the main branches will be prospectively and consecutively enrolled. control group patients will be selected from the database. jailed side branches need to have an ostial stenosis \>50%, vessel size \>2 mm, vessel length \>40 mm and lesion length \<10 mm by visual estimation. study procedure coronary stenting of the main branch should be performed with standard interventional techniques using drug-eluting stents. in the ffr group, pressure measurement would be performed using a 0.014 inch pressure guide wire (pressurewire, radi medical systems, uppsala, sweden)lesions with an ffr \<0.75 are considered to have functionally significant stenosis and side branch balloon dilatation is allowed only for these lesions. it is recommended to use a smaller balloon than the side branch vessel diameter. after kissing balloon inflation, ffr will be measured again at the same site and further intervention is only recommended when ffr was \<0.75 after kissing balloon dilatation. in the conventional group, the decision to treat the side branch lesion and the method of intervention are all up to the operators' discretion.

Eligibility criteria:
inclusion criteria: jailed side branches with an ostial stenosis \>50%, vessel size \>2mm, vessel length \>40mm and lesion length \<10mm by visual estimation. exclusion criteria: st elevation myocardial infarction left main stenosis, totally occluded lesion angiographically visible thrombus, significant lesion within the main branch proximal to the stented segment, significant distal lesion at a side branch regional wall motion abnormalities of the stented artery and jailed side branch segments left ventricular ejection fraction\ 2mg/dl predilatation of side branch before the main branch stent implantation contraindications to adenosine

Keywords: fractional flow reserve bifurcation stent
impact of new tools of simulation-enhanced peer learning on neonatal and maternal mortality

Conditions: Neonatal Mortality; Maternal Mortality

Summary: in the vast majority of developing nations, frontline birth attendants are often the only care providers responsible for newborn care including newborn resuscitation, thermal care, feeding and administration of medications. these midwives need knowledge and skills to provide all these newborn clinical care needs. however, frontline birth attendants in these circumstances are seldom exposed to the training and decision support tools that would empower them to holistically assess, decide and manage newborn babies in their care. current training opportunities are fragmented and need to be administered as a comprehensive package. a combination approach to training, skills retention, and the use of decision support tools such as protecting infants remotely by sms (prisms) and augmented infant resuscitator (air) may provide a comprehensive package for the acquisition and retention of knowledge and skills on newborn care and empower birth attendants to provide effective, timely interventions.

the investigators will implement the sim for life impart, retain, empower and monitor (irem) module at the university of jos teaching hospital and 4 high volume health facilities in tanzania in addition to the uganda sites. we propose to implement the program with all its components for each of the partner institutions. the sim for life irem module combines four strategies: impart skills using helping babies survive (hbs)/helping mothers survive (hms) courses, retain skills (simulation), empower birth attendants (prisms and air) and monitor progress objectively. the simulation sessions for health facilities will be conducted using the peer to peer learning methodology which equips participants with the skills to facilitate simulation scenarios in their health facilities. the scenarios will be provided by the sim for life team. the topics for the scenarios will be based on common maternal and newborn illnesses like post-partum hemorrhage, pre-eclampsia, birth asphyxia, neonatal sepsis and prematurity. all health facilities in this study will require smart phones for the prisms application, resuscitation practice tables, source of electricity to charge a phone, practice manikins / associated practice supplies and peer learning cards.

Eligibility criteria:
inclusion criteria: * newborns babies * mothers delivering at participating health facilities * health workers providing maternal and newborn care services at participating health facilities exclusion criteria: * health care workers not providing maternal and newborn care services * male patients * non pregnant female patients seeking care at participating health facilities
massage, oxidative and antioxidant enzymes in hemodialysis patients with restless legs syndrome(rls)

Conditions: Renal Failure Chronic; Restless Legs Syndrome

Summary: this study; it will be done to evaluate the presence of oxidative stress and its effects on lipid peroxidation products and antioxidant parameters after massage application and the possible effects of the appropriate massage protocol applied to the patients on oxidative stress in hemodialysis patients with restless legs syndrome.

in this study, the following research hypotheses will be tested. h0a: individuals with restless legs syndrome receiving hemodialysis treatment; in the second hour of hemodialysis, massage applied to both calf muscles for 10 minutes three times a week for one month is not affect the oxidative and antioxidant enzymes of the patients. h1a: individuals with restless legs syndrome receiving hemodialysis treatment; in the second hour of hemodialysis, massage applied to both calf muscles for 10 minutes three times a week for one month is effective on the oxidative and antioxidant enzymes of the patients.

Eligibility criteria:
inclusion criteria: 1. receiving hemodialysis treatment for at least 6 months, 3 days a week for 4 hours, 2. patients with rls according to the diagnostic criteria of the international rls study group, 3. no psychiatric problems, 4. no neurological deficit, 5. exercise and physical therapy modalities have not been applied in the last year, 6. in the laboratory examinations, the kinetic indicators of dialysis adequacy are within the desired target range (kt/v: 1.2-1.3; urr: 60-65%), and there are no pathological findings (fracture, dislocation, tumor, infection) in the radiological examinations. . exclusion criteria: 1. hemiplegic patients 2. patients with heart failure 3. individuals with chronic obstructive pulmonary diseases

Keywords: renal failure
core outcome set for head, neck and respiratory disease in mucopolysaccharidosis ii

Conditions: Mucopolysaccharidosis Type II

Summary: the mucopolysaccharidoses (mps) are a family of genetic metabolic disorders, caused by specific enzyme deficiencies which result in accumulation of partially degraded glycosaminoglycans (gags) within various tissues. as gags are common in the body a number of different organ systems can be affected. involvement of the upper and lower respiratory tract in mps type ii results in significant airway compromise, with progressive airway obstruction being responsible for a significant proportion of the morbidity and mortality associated with this condition. hearing loss is a universal finding in mps, with a third of patients suffering with severe profound hearing loss. there is an unmet need for strong clinical evidence to guide treatment of head, neck and respiratory disease in mps disorders. a core outcome set (cos) describes the minimum outcome data that should be measured in a clinical study for a particular condition. the lack of an agreed cos for mps ii in general, and specifically head, neck and respiratory disease, makes comparison between studies difficult. there is also a lack of information detailing patient and parent perspectives on the mps disorders. the ideal cos for head, neck and respiratory disease associated with mps ii would combine both patient/parent and clinician opinion and could be used in the design of all subsequent clinical studies. following literature review the investigators have created a list of outcomes previously reported for qualitative and quantitative studies investigating head, neck and respiratory disease in mps ii. for the proposed research the investigators will seek opinions of patients, parents, clinicians and scientists to rate these outcomes via the delphi method. outcomes scored highest by patients, parents, clinicians and scientists will form a cos for head, neck and respiratory disease in mps ii. the development of a cos can help limit variability outcomes in studies investigating different interventions in mps ii.


Eligibility criteria:
inclusion criteria: * confirmed mps ii diagnosis. * aged between 12 and 25 years old. * parents/ main care givers of child with mps type ii. * adults aged 18 or over. * clinicians responsible for direct care and management of at least 2 pediatric mps type ii patients in the last 12 months. * scientists who have worked with mps type ii within the last 5 years exclusion criteria: * unconfirmed mps type ii diagnosis. * aged below 12 and above 25 years old. * not directly involved in a day to day care. * clinicians who only occasionally look after pediatric mps type ii patients. * scientists who have not worked with mps type ii within the last 5 years
korean registry of non-small cell lung cancer patients with egfr mutation

Conditions: NSCLC

Summary: korean registry of non-small cell lung cancer patients with egfr mutation to collect and analyze the patient's clinical features, diagnosis, and treatment results.

the korean egfr registry is a prospective multicenter observational cohort study designed to enroll all stage egfr-mutated non-small cell lung cancer (nsclc) patients. however, due to the extended follow-up period required to confirm clinical outcomes, a retrospective cohort has been included. this retrospective cohort comprises patients with recurrent or metastatic nsclc who began taking egfr tki after january 2021. the recruitment phase was planned to span 36 months, commencing in may 2022, with scheduled follow-up activities continuing until december 2026. the target enrollment for this study is set at 2,000 patients, with competitive enrollment to be carried out across 40 university hospitals in korea.

Eligibility criteria:
inclusion criteria: 1. adults over 20-year-old with korean nationality 2. a person who voluntarily signed the informed consent form for this study 3. all stage non small cell lung cancer patients with egfr mutation or metastatic or recurred egfr mutated nsclc patients started with egfr tki treatment from 2021-01-01. exclusion criteria: 1. a person who is not confirmed nsclc histologically or cytologically. 2. a person who doesn't consent to the study. 3. a person who is unable to complete the study judged by the investigator.
nutritional status and barriers to dietary intake in head and neck cancer patients

Conditions: Head and Neck Cancer

Summary: the investigators hope to learn more about how side-effects of rt or rtchemo affect food intake and nutrition status.

head and neck cancer patients often have difficulty meeting their nutritional needs while undergoing radiation therapy (rt) and/or chemotherapy (rtchemo). tumor locations and side effects of rt or rtchemo, including dry mouth, mouth sores, difficulty chewing and swallowing, changes in taste and smell, and loss of appetite, lead to poor food intake and weight loss. the investigators hope to learn more about how side-effects of rt or rtchemo affect food intake and nutrition status.

Eligibility criteria:
inclusion criteria: * 18 years or older * diagnosed with head and neck cancer including the lip, oral cavity, salivary glands, paranasal sinuses, oropharynx, nasopharynx, hypopharynx, larynx, and thyroid * all histological types of cancer * all tumour stages according to american joint committee for cancer (ajcc) staging * all forms of rt including standard or investigational and/or concurrent standard or investigational chemotherapy for head and neck cancers * alert and mentally competent * english speaking exclusion criteria: * unwilling to participate

Keywords: food diet mucositis xerostomia dysphagia taste smell head and neck radiation chemotherapy
resveratrol and type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the main objective of the study is to investigate if resveratrol supplementation can improve overall and muscle-specific insulin sensitivity in type 2 diabetic patients. as a secondary objective the investigators want to investigate whether the improved insulin sensitivity can be attributed to improved muscle mitochondrial oxidative capacity and a reduced intrahepatic and cardiac lipid content.


Eligibility criteria:
inclusion criteria: * male sex * age: 40-70 years * body fat percentage \> 25, bmi 27-35 kg/m2 * diagnosed with type 2 diabetes at least one year before the start of the study * well-controlled type 2 diabetics: hba1c \< 8.0% * oral glucose lowering medication (metformin only or in combination with sulfonylurea agents) * sedentary * not more than 2 hours of sports a week * no active job that requires strenuous physical activity * stable dietary habits * willingness to abstain from resveratrol-containing food products exclusion criteria: * unstable body weight (weight gain or loss \> 3kg in the last three months) * total body fat percentage \< 25% * hemoglobin \< 7.8 mmol/l * use of anticoagulants * engagement in programmed exercise \> 2 hours total per week * impaired kidney and/or hepatic function creatinine 50-100 umol/l liver enzymes, within 2 times of normal range of laboratory standard (asat \< 60 u/l, alat \< 70 u/l, billi \<40 umol/l, gamma-gt \< 80 u/l) * no diabetes related co-morbidities like cardiovascular diseases, diabetic foot, polyneuropathy, retinopathy * insulin dependent diabetic subjects * any medical condition except type 2 diabetes mellitus requiring treatment and/or medication use except metformin only or in combination with sulfonylurea agents * intake of dietary supplements except multivitamins and minerals * current alcohol consumption \> 20 grams/day * subjects who don't want to be informed about unexpected medical findings during the screening /study, or do not wish that their physician is informed, cannot participate in the study. * participation in another biomedical study within 1 month before the first screening visit * any contraindication to mri scanning. these contra-indications include patients with following devices: * central nervous system aneurysm clip * implanted neural stimulator * implanted cardiac pacemaker of defibrillator * cochlear implant * insulin pump * or metal containing corpora aliena in the eye or brains
post-market clinical follow up study with navitor valve

Conditions: Aortic Stenosis

Summary: evaluation of the safety and performance of the navitor tavi system in a global study

the vista nova study will evaluate the safety, performance, and long-term durability of the navitor valve in a real-world setting.

Eligibility criteria:
inclusion criteria: * patient is eligible per the current approved indication after heart team discussion and intended to undergo a navitor tavi procedure. * the patient has been informed of the nature of the study, agrees to its provisions, and has provided written informed consent as approved by the irb (investigational review board)/ec (ethics committee) of the respective clinical site. * the patient and the treating physician agree that the subject will return for all required post procedure follow up visits. exclusion criteria: * patient is not eligible for the navitor tavi system per the current instructions for use (ifu) * life expectancy \< 12 months from the time of informed consent due to non-cardiac co-morbid conditions. * in the judgment of the investigator, patient presents with a medical, social, or psychological condition that could limit the ability or willingness to participate in the study, comply with study required testing and/or follow-up visits or that could impact scientific integrity of the study. * known contraindication for computed tomography (ct) or sensitivity to contrast media, which cannot be adequately premedicated. * inability to tolerate antiplatelet/anticoagulation therapy or nitinol alloy (nickel and titanium), which cannot be adequately premedicated. * currently participating in an investigational drug or device study that may confound the results of this study * anatomy that makes insertion and endovascular access to the aortic valve difficult and/or impossible

Keywords: navitor transcatheter aortic valve implantation (tavi) aortic stenosis cardiovascular disease