a study comparing the combination of dasatinib or imatinib and chemotherapy treatment with or without blinatumomab for children, adolescents, and young adults with philadelphia chromosome positive (ph+) or abl-class philadelphia chromosome-like (ph-like) b-cell acute lymphoblastic leukemia (b-all)

Conditions: B Acute Lymphoblastic Leukemia

Summary: this phase iii trial compares the effect of the combination of blinatumomab with dasatinib or imatinib and standard chemotherapy versus dasatinib or imatinib and standard chemotherapy for treating patients with philadelphia chromosome positive (ph+) or abl-class philadelphia chromosome-like (ph-like) b-cell acute lymphoblastic leukemia (b-all). blinatumomab is a bispecific antibody that binds to two different proteins-one on the surface of cancer cells and one on the surface of cells in the immune system. an antibody is a protein made by the immune system to help fight infections and other harmful processes/cells/molecules. blinatumomab may bind to the cancer cell and a t cell (which plays a key role in the immune system's fighting response) at the same time. blinatumomab may strengthen the immune system's ability to fight cancer cells by activating the body's own immune cells to destroy the tumor. dasatinib and imatinib are in a class of medications called tyrosine kinase inhibitors. they work by blocking the action of an abnormal protein that signals cancer cells to multiply, which may help keep cancer cells from growing. giving blinatumomab and dasatinib or imatinib in combination with standard chemotherapy may work better in treating patients with ph+ or ph-like abl-class b-all compared to dasatinib or imatinib and chemotherapy alone.

primary objectives: i. to estimate the 3-year event free survival (efs) of children, adolescents, and young adults \<25 years old with newly-diagnosed ph+ (bcr::abl1-rearranged) b- all who are treated with a modified berlin-frankfurt-münster (mbfm) chemotherapy backbone that incorporates three cycles of blinatumomab without traditional consolidation chemotherapy in combination with continuous dasatinib. ii. to estimate the 3-year efs of children, adolescents, and young adults \<25 years old with newly-diagnosed abl-class ph-like b-all who are treated with a modified bfm chemotherapy backbone that incorporates three cycles of blinatumomab without traditional consolidation chemotherapy in combination with continuous imatinib for those with pdgfrb gene fusions or dasatinib for those without pdgfrb gene fusions. iii. to describe the safety and toxicity profile (infections, mucositis, neurotoxicity, cytokine release syndrome, hypogammaglobulinemia, therapy delays \> 14 days, and treatment-related mortality) for patients with ph+ or abl-class ph-like b-all treated on this novel chemo-immunotherapy backbone with continuous tyrosine kinase inhibitor (tki). secondary objectives: i. to estimate the 3-year overall survival (os) of patients with ph+ and abl-class ph-like b-all, respectively. ii. to estimate the 3-year efs, disease-free survival (dfs), cumulative incidence rates (cir) of relapse, and treatment related mortality (trm), and os of patients with abl-class ph-like b-all stratified by their underlying abl-class fusion subtypes. iii. to describe rates of end of consolidation (eoc)/timepoint 2 (tp2) minimal residual disease (mrd) negativity defined as \<1x10-4 or \<0.01% for patients with ph+ b-all. iv. to describe rates of eoc/tp2 mrd negativity defined as \<1x10-4 or \<0.01% for patients with abl-class ph-like b-all collectively and based on their abl-class fusion subtypes. exploratory objectives: i. to describe rates of end of induction (eoi)/timepoint 1 (tp1) bone marrow mrd negativity defined as \<1x10\^-4 or \<0.01% with the introduction of the relevant tki during induction for patients with ph+ and abl-class ph-like b-all, respectively. ii. to describe the outcomes of patients with ph+ and abl-class ph-like b-all who are removed from protocol therapy due to consolidation failure. iii. to describe the percentage of patients with ph+ and abl-class ph-like b-all who continue tki beyond protocol-prescribed therapy and their outcomes. iv. to describe the impact of mrd by next-generation sequencing (ngs) at end of consolidation on outcomes for patients with ph+ and abl-class ph-like b-all. v. to describe the clinical characteristics and outcomes of patients with chronic myeloid leukemia-like biology. vi. to describe the immune function of patients with ph+ and abl-class ph-like b-all pre- and post-blinatumomab plus tki and correlate with treatment response. vii. to describe the tki levels in the plasma and cerebrospinal fluid of children with ph+ and abl-class ph-like b-all over the treatment course and correlate with outcome viii. to describe the impact of tkis and high-dose methotrexate interaction and identify clinical and biologic factors influencing methotrexate clearance. outline: arm i (ph+ b-all patients): induction part i: patients receive dasatinib orally (po) once daily (qd) days 1-14 per standard of care (soc). induction part ii: patients receive dasatinib po qd on days 15-29, daunorubicin intravenously (iv) over 15 minutes on days 15 and 22, prednisolone or prednisone po twice daily (bid) on days 15-28, vincristine iv on days 15 and 22, methotrexate intrathecally (it) on days 15, 22, and 29, and cytarabine it on days 18 and 25 for 2 weeks on study. consolidation part i: patients receive dasatinib po qd on days 1-28, cyclophosphamide iv over 30-60 minutes on day 1, cytarabine iv over 30 minutes on says 1-4 and 8-11, mercaptopurine po qd on days 1-14, methotrexate it on days 1, 8, 15 and 22, pegaspargase iv or calaspargase pegol iv over 1-2 hours on day 15, and vincristine iv on days 1 and 22 over 4 weeks on study. consolidation part ii: patients receive dasatinib po qd on day 29 until the end of consolidation, cyclophosphamide iv over 30-60 minutes on day 29, cytarabine iv over 30 minutes on days 29-32 and 36-39, mercaptopurine po qd on days 29-42, methotrexate it on days 1, 8, 15 and 22, pegaspargase iv or calaspargase pegol iv over 1-2 hours on day 43, and vincristine iv on days 43 and 50 over 4 weeks on study. interim maintenance i: patients receive dasatinib po qd until the end of interim maintenance i, mercaptopurine po qd on days 1-56, vincristine iv on days 8, 22, 36, and 50, methotrexate it on days 8 and 36, high-dose methotrexate iv over 24 hours on days 8, 22, 36 and 50, and leucovorin po or iv on days 10, 11, 24, 25, 38, 39, 52 and 53 over 9 weeks on study. delayed intensification part i: patients receive dasatinib po qd on days 1-28, methotrexate it on day 1, dexamethasone po or iv on days 1-7 and 15-21, doxorubicin iv over 15 minutes on days 1, 8, and 15, vincristine iv on days 1, 8, and 15, and pegaspargase iv or calaspargase pegol iv over 1-2 hours on day 4 over 9 weeks on study. delayed intensification part ii: patients receive dasatinib po qd on day 29 until the end of delayed intensification part ii, cyclophosphamide iv over 60 minutes on day 29, cytarabine iv over 30 minutes on days 29-32 and 36-39, methotrexate it on days 29 and 36, thioguanine po on days 29-42, pegaspargase iv or calaspargase pegol on day 43 and vincristine iv on days 43 and 50 over 9 weeks on study. interim maintenance part ii: patients receive dasatinib po qd on day 1 until the end of interim maintenance part ii, methotrexate iv on days 1, 11, 21, 31, and 41, vincristine iv on 1, 11, 21, 31, and 41, methotrexate it on days 1 and 31, and pegaspargase iv or calaspargase pegol iv over 1-2 hours on days 2, 22 and 23 over 9 weeks on study. maintenance: patients receive dasatinib po qd on days 1-84, methotrexate it on days 1 and 29, dexamethasone po bid or iv on days 1-5, 29-33, and 57-61, mercaptopurine po on days 1-84, vincristine iv on days 1, 29 and 57, and methotrexate po on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78 on study. cycles repeat every 12 weeks for 2 years in the absence of disease progression or unacceptable toxicity. patients are assigned to 1 of 2 arms. arm ii (pdgfrb abl-class fusions): blinatumomab block i: patients receive dexamethasone po or iv on day 1, blinatumomab iv on days 1-28, imatinib po on days 1-35, and methotrexate it on days 1 and 15 over 5 weeks on study. patients may undergo radiation therapy in 12 qd fractions. blinatumomab block ii: patients receive dexamethasone po or iv on day 1, blinatumomab iv on days 1-28, imatinib po on days 1-35, and methotrexate it on days 1 and 15 over 5 weeks on study. interim maintenance i: patients receive imatinib po qd until the end of interim maintenance i, mercaptopurine po qd on days 1-56, vincristine iv on days 8, 22, 36, and 50, methotrexate it on days 8 and 36, high-dose methotrexate iv over 24 hours on days 8, 22, 36 and 50, and leucovorin po or iv on days 10, 11, 24, 25, 38, 39, 52 and 53 over 9 weeks on study. blinatumomab block iii: patients receive blinatumomab iv on days 1-28, imatinib po qd on days 1-35, and methotrexate it on day 1 over 9 weeks on study. delayed intensification part i: patients receive imatinib po qd on days 1-28, methotrexate it on day 1, dexamethasone po or iv on days 1-7 and 15-21, doxorubicin iv over 15 minutes on days 1, 8, and 15, vincristine iv on days 1, 8, and 15, and pegaspargase iv or calaspargase pegol iv over 1-2 hours on day 4 over 9 weeks on study. delayed intensification part ii: patients receive imatinib po qd on day 29 until the end of delayed intensification part ii, cyclophosphamide iv over 30-60 minutes on day 29, cytarabine iv over 1-30 minutes subcutaneously on days 29-32 and 36-39, methotrexate it on days 29 and 36, thioguanine po on days 29-42, and pegaspargase iv over 1-2 hours or imtramuscularly (im) on day 43 or calaspargase pegol iv over 1-2 hours on day 43, and vincristine iv on day 43 and 50 on study. all patients undergo echocardiography (echo) or multigated acquisition scan (muga) during screening. patients also undergo blood and cerebrospinal fluid (csf) sample collection and bone marrow biopsy throughout the study and as clinically indicated on study. interim maintenance ii: patients receive imatinib po qd until the end of interim maintenance ii, methotrexate iv and vincristine iv on days 1, 11, 21, 31 and 41, methotrexate it on days 1 and 31, and pegaspargase iv over 1-2 hours or imtramuscularly (im) on days 2 and 22 or calaspargase pegol iv over 1-2 hours on day 22 and 23 on study. maintenance cycles i-ii: patients receive imatinib po qd on days 1-84, methotrexate it on days 1 and 29, dexamethasone po bid or iv on days 1-5, 29-33, and 57-61, mercaptopurine po on days 1-84, vincristine iv on days 1, 29 and 57, and methotrexate po on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78 on study. cycles repeat every 12 weeks for cycles in the absence of disease progression or unacceptable toxicity. maintenance cycles iii and subsequent cycles: patients receive imatinib po qd on days 1-84, methotrexate it on day 1, dexamethasone po bid or iv on days 1-5, 29-33, and 57-61, mercaptopurine po on days 1-84, vincristine iv on days 1, 29 and 57, and methotrexate po on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78 on study. cycles repeat every 12 weeks in the absence of disease progression or unacceptable toxicity. arm iii (non-pdgfrb abl-class fusions): blinatumomab block i: patients receive dexamethasone po or iv on days 1 and 8, blinatumomab iv on days 1-28, dasatinib po on days 1-35, and methotrexate it on days 1 and 15 over 5 weeks on study. patients may undergo radiation therapy in 12 qd fractions. blinatumomab block ii: patients receive dexamethasone po or iv on day 1, blinatumomab iv on days 1-28, dasatinib po on days 1-35, and methotrexate it on days 1 and 15 over 5 weeks on study. interim maintenance i: patients receive dasatinib po qd until the end of interim maintenance i, mercaptopurine po qd on days 1-56, vincristine iv on days 8, 22, 36, and 50, methotrexate it on days 8 and 36, high-dose methotrexate iv over 24 hours on days 8, 22, 36 and 50, and leucovorin po or iv on days 10, 11, 24, 25, 38, 39, 52 and 53 over 9 weeks on study. blinatumomab block iii: patients receive blinatumomab iv on days 1-28, dasatinib po on days 1-35, and methotrexate it on day 1 over 9 weeks on study. delayed intensification part i: patients receive dasatinib po qd on days 1-28, methotrexate it on day 1, dexamethasone po or iv on days 1-7 and 15-21, doxorubicin iv over 15 minutes on days 1, 8, and 15, vincristine iv on days 1, 8, and 15, and pegaspargase iv or calaspargase pegol iv over 1-2 hours on day 4 over 9 weeks on study. delayed intensification part ii: patients receive dasatinib po qd and methotrexate it on day 29 until the end of delayed intensification part ii, cyclophosphamide iv over 30-60 minutes on day 29, cytarabine iv over 1-30 minutes or subcutaneously on days 29-32 and 36-49, methotrexate it on days 29 and 36, thioguanine po on days 29-42, and pegaspargase iv over 1-2 hours or imtramuscularly (im) on day 43 or calaspargase pegol iv over 1-2 hours on day 43, and vincristine iv on day 43 and 50 on study. all patients undergo echocardiography (echo) or multigated acquisition scan (muga) during screening. patients also undergo blood and cerebrospinal fluid (csf) sample collection and bone marrow biopsy throughout the study and as clinically indicated on study. interim maintenance ii: patients receive dasatinib po qd until the end of interim maintenance ii, methotrexate iv and vincristine iv on days 1, 11, 21, 31 and 41, methotrexate it on days 1 and 31, and pegaspargase iv over 1-2 hours or imtramuscularly (im) on days 2 and 22 or calaspargase pegol iv over 1-2 hours on day 22 and 23 on study. maintenance cycles i-ii: patients receive dasatinib po qd on days 1-84, methotrexate it on days 1 and 29, dexamethasone po bid or iv on days 1-5, 29-33, and 57-61, mercaptopurine po on days 1-84, vincristine iv on days 1, 29 and 57, and methotrexate po on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78 on study. cycles repeat every 12 weeks for cycles in the absence of disease progression or unacceptable toxicity. maintenance cycles iii and subsequent cycles: patients receive dasatinib po qd on days 1-84, methotrexate it on day 1, dexamethasone po bid or iv on days 1-5, 29-33, and 57-61, mercaptopurine po on days 1-84, vincristine iv on days 1, 29 and 57, and methotrexate po on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78 on study. cycles repeat every 12 weeks in the absence of disease progression or unacceptable toxicity.

Eligibility criteria:
inclusion criteria: * patients must be \> 365 days and \ 365 days and \ 365 days and \< 46 years (for alltogether sites) at the time of enrollment * newly-diagnosed ph+ or ph-like abl-class b-all. leukemic blasts must express cd19. abl-class fusions are defined as rearrangements involving the following genes predicted to be sensitive to imatinib and/or dasatinib: abl1, abl2, csf1r, and pdgfrb * evidence of bcr::abl1 should be documented by a clinically-validated assay prior to study entry on day 15 from the first dose of vincristine during induction therapy. abl-class ph-like b-all gene rearrangements should be documented by a clinically-validated assay and enrolled on study by day 1 of blinatumomab block 1. accepted methods of detection include fluorescence in situ hybridization (fish) using break-apart of colocalization signal probes, singleplex or multiplex reverse-transcription polymerase chain reaction (rt-pcr), whole-transcriptome or panel-based ribonucleic acid (rna) sequencing (e.g., hematologic cancer fusion analysis, trusight rna pan-cancer panel or equivalent). confirmation of 5' fusion partner genes is not required for study enrollment * patients with ph+ b-all must have previously started induction therapy, which includes vincristine, a corticosteroid, pegaspargase or calaspargase pegol, with or without anthracycline, and/or other standard cytotoxic chemotherapy * patients with ph+ b-all have not received more than 14 days of systemic induction therapy beginning with the first induction dose of vincristine * patients with abl-class ph-like b-all must have previously completed 4 or 5 weeks of multiagent induction chemotherapy (induction 1a) * patients may have started either imatinib or dasatinib prior to study entry but should have received no more than 14 days of tki for ph+ b-all or no more than 35 days of tki for abl-class ph-like b-all * patients must have a performance status corresponding to eastern cooperative oncology group (ecog) scores of ≤ 2 or karnofsky and lansky performance scores ≥ 50%. use karnofsky for patients \> 16 years of age and lansky for patients ≤ 16 years of age * for pediatric patients (age 1-17 years): a glomerular filtration rate (gfr) ≥ 50 ml/min/1.73 m\^2, as determined by one of the following methods (must be performed within 7 days prior to enrollment unless otherwise indicated): * estimated gfr (egfr) ≥ 50 ml/min/1.73 m2 * measured gfr ≥ 50 ml/min/1.73 m\^2 (any age). if measured gfr is used, it must be performed using direct measurement with a nuclear blood sampling method or small molecule clearance method (iothalamate or other molecule per institutional standard * for adult patients (age 18 years or older): creatinine clearance ≥ 30 ml/min, as estimated by the cockcroft and gault formula. the creatinine value used in the calculation must have been obtained within 28 days prior to registration. estimated creatinine clearance is based on body weight * direct bilirubin \< 2.0 mg/dl (34.2 micromoles/l) (must be performed within 7 days prior to enrollment unless otherwise indicated) * alanine aminotransferase (alt) and aspartate aminotransferase (ast) ≤ 10 x upper limit of normal (uln) (must be performed within 7 days prior to enrollment unless otherwise indicated) * \* shortening fraction of ≥ 27% by echocardiogram (must be obtained within 21 days prior to enrollment and start of protocol therapy \[repeat if necessary\]) or * left ventricular ejection fraction of ≥ 50% by radionuclide angiogram or echocardiogram (must be obtained within 21 days prior to enrollment and start of protocol therapy \[repeat if necessary\]) and * corrected qt interval, qtc \< 480msec (must be obtained within 21 days prior to enrollment and start of protocol therapy \[repeat if necessary\]) * note: repeat echocardiogram and electrocardiogram are not required if they were performed at or after initial all diagnosis before study enrollment exclusion criteria: * known history of chronic myeloid leukemia (cml) * abl-class ph-like b-all who are cns2 or cns3 at end of induction phase * all developing after a previous cancer treated with cytotoxic chemotherapy * active, uncontrolled infection or active systemic illness that requires ongoing vasopressor support or mechanical ventilation * down syndrome (trisomy 21) * pregnancy and breast feeding * female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs. a negative pregnancy test is required for female patients of childbearing potential within 7 days prior to enrollment * lactating females who plan to breastfeed their infants * sexually active male and female patients of reproductive potential who have not agreed to use an effective contraception method for the duration of treatment according to protocol * note: patients who could become pregnant or could father a child must use effective contraception during protocol treatment and for 30 days after the last dose of dasatinib or 14 days after the last dose of imatinib dose or per institutional standard of care for multiagent chemotherapy, whichever is longer * prior treatment with tkis before study entry with the exception of imatinib or dasatinib * patients with congenital long qt syndrome, history of ventricular arrhythmias, or heart block * patients with known charcot-marie-tooth disease * patients with significant central nervous system pathology that would preclude treatment with blinatumomab, including history of severe neurologic disorder or autoimmune disease with central nervous system (cns) involvement * note: patients with a history of seizures that are well controlled on stable doses of anti-epileptic drugs are eligible. patients with a history of cerebrovascular ischemia/hemorrhage with residual deficits are not eligible. patients with a history of cerebrovascular ischemia/hemorrhage remain eligible provided all neurologic deficits have resolved * hiv-infected patients are eligible if on effective anti-retroviral therapy that does not interact with planned study agents and with undetectable viral load within 6 months of treatment * all patients and/or their parents or legal guardians must sign a written informed consent * all institutional, food and drug administration (fda), and national cancer institute (nci) requirements for human studies must be met