Kornimate/medical-research-clean huggingface dataset:
peripheral airway biopsy in sarcoidosis

Conditions: Sarcoidosis, Pulmonary

Summary: airway involvement in sarcoidosis was demonstrated in a meaningful, albeit variable, proportion of patients through biopsy of the central, endoscopically visible airways. ideally, biopsy of peripheral airways, nowadays possible with the introduction in the market of ultrathin bronchoscopes, might be associated with an increased diagnostic yield for the detection of granulomas.

sarcoidosis is a systemic disorder of unknown cause that primarily involves the lung and lymphatic systems and that is more reliably diagnosed if a compatible clinical picture is combined with a pathologic demonstration of non-necrotizing epithelioid-cell granulomas. endobronchial biopsy (ebb), taken from the central airways with standard-sized videobronchoscopes, has long been used in clinical practice, although its diagnostic yield has been shown to be widely variable across different ethnicities. a recent prospective study shows that the diagnostic yield of ebb in a sarcoidosis population with large prevalence of white europeans is 37% overall, and 22% in patients who do not have endobronchial abnormalities. the diagnostic yield of biopsies taken from peripheral airways with ultrathin bronchoscopes was never been evaluated, to our knowledge.

Eligibility criteria:
inclusion criteria: * necessity of a pathological confirmation of the clinical and radiological (ct) diagnosis of sarcoidosis. * age \>18 years * american society of anesthesiologists score 1-3. exclusion criteria: * inability of unwillingness to consent * steroid therapy (at least 1 week) in the 2 months preceding bronchoscopy. * pregnancy. * uncontrolled coagulopathy * contraindication to the temporary interruption of anticoagulants or antiplatelet drugs, except aspirin.

Keywords: sarcoidosis bronchoscopy
hernia reduction prior to scheduled tif completion

Conditions: Fundoplication

Summary: hernia reduction prior to scheduled tif completion using esophyx zr transoral device

evaluation of the relative merits, safety and effectiveness of the esophyx zr transoral device in performing the standardized tif 2.0 procedure preceded by laparoscopic hiatal hernia repair in ppi-prescribed patients with persistent "troublesome symptoms" per the montreal consensus definition

Eligibility criteria:
inclusion criteria: 1. age 18-72 years 2. dependent upon daily ppis for \> 6 months. daily use is defined as a double dose, or full dose or half dose taken daily for more than 80% of the total number of days during the proceeding evaluation period 3. troublesome symptoms, specifically heartburn or regurgitation, while on optimized dose of ppi's troublesome heartburn or regurgitation symptoms are those which occur a minimum of 2 days a week and are mild to severe in severity 4. abnormal ambulatory (bravo) ph study after off ppi therapy for 7 days, i.e. \> 5.3% of the time with ph \< 4 in a 48-hour monitoring period 5. normal or near normal esophageal motility (by upper gi/ esophagram or manometry as required) 6. pre-enrollment hiatal hernia (axial height and transverse dimension) from \> 2 cm up to 4 cm inclusive. 7. patient willing to cooperate with post-operative dietary recommendations and assessment tests at the requisite follow-up visits 8. signed informed consent exclusion criteria 1. bmi \> 35 2. hiatal hernia ≤ 2 and \> 4 cm 3. esophagitis los angeles grade c or d 4. esophageal ulcer 5. esophageal stricture 6. long-segment barretts esophagus (prague: c \> 1, m \> 3) 7. esophageal motility disorder 8. pregnancy or plans for pregnancy in the next 12 months (in females) 9. immunosuppression 10. asa \> 2 11. portal hypertension and/or varices 12. history of previous resective gastric or esophageal surgery, cervical spine fusion, zenker's diverticulum, esophageal epiphrenic diverticulum, achalasia, scleroderma or dermatomyositis, eosinophilic esophagitis, or cirrhosis 13. active gastro-duodenal ulcer disease 14. gastric outlet obstruction or stenosis 15. severe gastroparesis or delayed gastric emptying confirmed by solid-phase gastric emptying study if patient complains of postprandial satiety during assessment 16. coagulation disorders 17. atypical symptoms including gas bloat and dysphagia. 18. any other presenting condition that in the opinion of the investigator would not make participation in this study in the patient's best interest. post enrollment exclusion - 1. inability to repair hiatal hernia with at least 2cm of intra-abdominal esophagus length.

Keywords: transoral incisionless
urinary ngal acute kidney injury after stored red blood cells transfusion in critically ill patients.

Conditions: Acute Kidney Injury; Anemia

Summary: the study aims to explore the association of the novel urinary bio marker ngal with the age of prbcs(packed red blood cells) transfusion in critically ill patients.

the investigators will measure the urinary ngal in all patients who received blood transfusion in the intensive care unit during the study period. the age of prbcs transfusion will be correlated with the incidence of aki. the rise of ngal and serum creatinine will be used to diagnose aki (acute kidney injury).

Eligibility criteria:
inclusion criteria: * any patients admitted to the intensive care unit. exclusion criteria: * patients who have established aki at the time of recruitment

Keywords: biomarkers
direct current neuromuscular electrical stimulation for treatment of peripheral neuropathy

Conditions: Neuropathy

Summary: this study will compare two methods of electrical stimulation (alternating current and direct current) as an adjunctive therapy to treating peripheral neuropathy. both types of electrical stimulation have been used in clinical practice for physical therapy, however direct current stimulation is much less common and there is less known about their impact on physical therapy outcomes. the aim of this project is to show the efficacy of a novel device, the neubie direct current device, compared to traditional tens unit, in clinical physical therapy treatment of neuropathy. outcomes measured will include three methods of two-point discrimination, vibration sense, pain, and score on the modified toronto clinical neuropathy scale.

to determine the efficacy of direct current electrical stimulation (the neubie device) on long-term symptoms and severity of neuropathy, participants will enroll in a 6-week treatment regimen at one of 9 hands on physical therapy associated clinic sites listed included in application. the first session will consist of an emg/ncs evaluation to determine severity of neuropathy and to rule out polyneuropathy, which will serve as baseline (and a within subject control) for the intervention. participants will then undergo a specialized neuropathy protocol that includes traditional pt therapy for neuropathy, as well as treatment with the neubie (or traditional e-stim) both during pt exercises and as additional treatment after sessions. subjects receive an evaluation session that includes an electrodiagnostic study, pain assessment, evaluation of two-point discrimination, and vibration sense. the experimental group subjects follow with 12 sessions of physical therapy over a 6-week period which include: a 30-min foot bath session with the neubie and 15-min of various physical therapy exercises. the control group subjects follow with 12 sessions of physical therapy over a 6-week period which include: a 30-min footbath with tens and 15-min of various physical therapy exercises. at the end of the 12 sessions of treatment, subjects receive a final evaluation session that includes an electrodiagnostic study, pain assessment, evaluation of two-point discrimination, and vibration sense. participants will receive 12 treatments over 6 weeks. emg/ncs and a neuropathy pain questionnaire will be measured at both the initial evaluation and at the completion of the final session, and will provide both quantitative and qualitative data on the severity of neuropathy symptoms.

Eligibility criteria:
inclusion criteria: * must have a minimum score of 1 on the modified toronto clinical neuropathy score * must be able to attend weekly sessions for the 6 week period of the study (no extended travel) * must be at least 18 years old. exclusion criteria: * currently pregnant * cardiac pacemaker * active or recent cancer in the lower limbs * active or recent blood clots in the lower limbs * history of epilepsy * no open wounds

Keywords: electrical stimulation neubie neuromuscular electrical stimulation
blood flow restriction exercise study

Conditions: Osteoarthritis, Knee

Summary: this pilot study will investigate the effects of blood flow restriction (bfr) exercise for up to 4-6 weeks prior to total knee arthroplasty (tka) surgery in older patients to measure clinical outcomes such as strength, lower extremity function, and pain.

the purpose of this study is to test the feasibility and efficacy of a low-resistance exercise protocol with blood flow restriction (bfr) using a tourniquet in the preoperative period of patients awaiting tka. bfr exercise is a new exercise method that has not been studied in the perioperative period. the investigators will compare our intervention to a no-exercise group up to 4 - 6 weeks prior to surgery to determine if this type of exercise is feasible in the preoperative period and if bfr exercise will improve functional, physiological, and molecular outcomes when compared to patients without exercise.

Eligibility criteria:
inclusion criteria: * are scheduled for elective tka for osteoarthritis * are scheduled for unilateral joint replacement surgery only * are able to give consent and follow instructions * are willing to complete up to 15 study visits exclusion criteria: * patients below the age of 55 years old * patients over the age of 80 years old * patients who live in a radius greater than 45 miles from the university of florida (a feasible distance to allow for transportation to and from the clinical center for assessment visits) * patients with impaired cognitive function and mental disease, (e.g. diagnosis of alzheimer's disease) * patients with paraplegia/extremity amputation * patients with end stage renal disease requiring dialysis * patients with uncontrolled diabetes and insulin-dependent diabetes * patients with uncontrolled cardiovascular disease e.g. (classes of heart failure (chf) new york heart association (nyha) class 3 or higher, bp \> 180/110 mmhg) * patients with severe pulmonary disease requiring continuous oxygen therapy * patients with active neoplasm * patients with peripheral vascular disease or deep vein thrombosis (within the last 3 years) * patients with structured exercise/physical therapy(pt)/occupational therapy (ot)/fitness program enrollment within 12 weeks prior to surgery and/or more than 2 hours per month on gym/fitness room exercises * patients with bmi greater than 40 kg/m2 * patients with opioid use of more than 30 mg morphine-equivalents per day * patients with chronic oral steroid use * patients with chronic anticoagulation (e.g. plavix, warfarin) * patients with planned postoperative admission to a skilled nursing/inpatient rehab facility * patients with ipsilateral joint disease involving hip, ankle or spine * neurologic or other etiology of quadriceps wasting * surgery within less than 4 weeks * patients with comorbidities that the pi judges as not suitable for the study * patients with a minimal mental status (mmse) score below 24

Keywords: elderly exercise
prevalence of stool outlet obstruction after laparoscopic sacrocolpopexie

Conditions: Stool Outlet Obstruction

Summary: the aim was to evaluate the prevalence of stool outlet obstruction after laparoscopic sacrocolpopexie at the kantonsspital aarau in a prospective cross-sectional study. laparoscopic sacrocolpopexy techniques involving the dissection of the presacral space can compromise fibers of the superior hypogastric plexus. this can contribute to postoperative problems such as incomplete voiding, defecatory dysfunction, pain, and sensory problems. in 2010, the kantonsspital aarau has implemented a new nerve-sparing laparoscopic sacrocolpopexy technique. this technique has subjectively reduced the prevalence of stool outlet obstructions but this has not been tested systematically yet. the aim of this study is therefore to compare the patients' subjective conditions between these two surgical techniques using the investigator's standard-of-care german pelvic floor questionnaire.

the (pre-) sacral space is characterized by a complex neuroanatomy and surgical intervention in this part of the body is often associated with the dissection of nerve bundels, a procedure which may finally lead to transient defecatory dysfunction. in a earlier study we could show that \~17.8% of patient with laparoscopic sacrocolpopexie developed postoperative constipation within 3-6 months. in november 2010 the frauenklinik aarau introduced a novel, nerve-sparing technique of laparoscopic sacrocolpopexie. in this study we assess the pre-and postoperative differences in defecatory dysfunction between the two procedures trough the analysis of our standard of care pelvic floor questionnaire.

Eligibility criteria:
inclusion criteria: * women affected by symptomatic vault prolapse, who underwent laparoscopic sacrocolpopexy at the ksa * informed consent exclusion criteria: * participation in other studies * sacrocolpopexie done by da vinci roboter * patients who had a conversion to laparotomy perioperatively * patients with a recurrence who had to undergo a second surgery * patients who had a relaps operation
intravenous metoclopramide versus dexketoprofen trometamol versus metoclopramide+ dexketoprofen trometamol in migraine

Conditions: Migraine

Summary: acute headache is one of the most common reasons for presentation to the emergency department (ed), accounting for 2-3% of all emergency visits. migraine is a disorder of the central nervous system characterized by a moderate or severe headache, which is generally associated with nausea and/or sensitivity to light and sound, interfering with daily activities.

study objective: the objective of this study is to determine the analgesic efficacy and safety of intravenous, single-dose metoclopramide versus dexketoprofen trometamol versus metoclopramide+ dexketoprofen trometamol in patients presenting with acute migraine attack to the emergency department (ed). methods of measurements: this single-center, randomized, double-blind study will be conducted in a tertiary care ed. eligible patients who met the migraine criteria of the international headache society will be randomized to receive 10 mg intravenous metoclopramide, 50 mg intravenous dexketoprofen trometamol, or 50 mg dexketoprofen trometamol + 10 mg metoclopramide. subjects reported pain intensity on both a 100-mm visual analogue scale (vas) (limited by 'no pain' and 'the worst pain') will be used for pain measurement at baseline, after 15 and 30 min. the primary outcome measure is the changes in the vas scores at the 15th and 30th minutes of treatment. the secondary outcome measures are the presence of adverse effects and the requirement of rescue medicine. primary data analysis: the study was planned as a superiority trial. the difference in the vas values between the groups was assumed to detect 21.4 mm and the standard deviation (sd) value as 2.8 mm, and thus the minimum required the number of patients for each group was calculated as 27 at the alpha-critical value of 0.05 and power of 80%. all the analyses were implemented according to the intention to treat analysis. differences between time intervals within groups and between groups and statistical significance were expressed by 95% confidence intervals (95% ci).

Eligibility criteria:
inclusion criteria: -patients aged 18 and over with acute headache who met the diagnostic criteria of the international headache association (9) for the diagnosis of migraine exclusion criteria: * patients who refused to participate in the study * patients that took any analgesic medication within six hours before presentation to ed patients with any additional organic pathology (e.g., hypertension, hypoglycemia, chronic kidney failure, and intracranial masses) pregnant women hemodynamically unstable patients patients with an allergy to the drugs used in the study
feasibility and impact of remote oximetry in patients hospitalized with covid-19

Conditions: Oximetry; Covid19

Summary: the objective of moxicov is to monitor the oximetry of patients admitted to the covid nursery to provide a more detailed assistance expecting to reduce the amount of hypoxia in these patients.


Eligibility criteria:
inclusion criteria: * over 18 years old * covid 19 positive or suspected covid19
interplay between oxytocin and cortisol during stress in borderline personality disorder

Conditions: Borderline Personality Disorder; Oxytocin

Summary: this study aims to determine the feasibility and preliminary data on the interaction between oxytocin and cortisol during stress in borderline personnality disorder.

the investigators will recruit 50 female patients with borderline personnality disorder and 50 controls with no psychiatric diagnosis, aged between 18 and 25 years old. salivary cortisol daily curve ( 6 measures during the day) will be measured in participant's naturalistic environnement, together with salivary oxytocin. in addition, salivary oxytocin and cortisol will be measured during a psychosocial stress task and recovery.

Eligibility criteria:
inclusion criteria: * borderline personality disorder-dsm v exclusion criteria: * schizophrenia

Keywords: cortisol tsst borderline personnality stress
total/subtotal colectomy in ovarian cancer

Conditions: Epithelial Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Carcinoma; Secondary Malignant Neoplasm of Large Intestine

Summary: the purpose of this study is to evaluate the safety and one year disease-free survival of total or subtotal colectomy and proctocolectomy in stage iiic and stage iv epithelial ovarian, fallopian tube, and primary peritoneal cancer (eoc, ftc, ppc).

this trial is to assess the perioperative complications, hospitalization expenses and days, and one year disease-free survival of patients who underwent total or subtotal colectomy as part of the surgical procedures for ovarian cancer, versus partial intestinal resection in the therapy for ovarian cancer.

Eligibility criteria:
inclusion criteria: * age ≥18 years and ≤ 75 years. * epithelial ovarian cancer, fallopian tube cancer, primary peritoneal carcinoma with pathology confirmed international federation of gynecology and obstetrics (figo) stage iiic or iv * extensive colonic metastasis, tumor involving the major part of bowel surface and/or mesentery * optimal cytoreductive surgery, including hysterectomy, bilateral salpinges-oophorectomy, omentectomy, and resection of all metastatic lesions, with a residual disease no more than 0.5cm * eastern cooperative oncology group (ecog) performance status 0-2. * american society of anesthesiologists (asa) performance 1-2. * follow-up available. * written informed consent. exclusion criteria: * low-malignant potential ovarian tumor. * patient who underwent enterostomy in the surgery procedure. * tumor involving small intestine alone. * more than 2 anastomoses. * other condition that could interfere with provision of informed consent, compliance to study procedures, or follow-up. * prior invasive malignancies within the last 5 years showing activity of disease.

Keywords: total or subtotal colectomy ovarian cancer complications one-year disease-free survival stage iiic stage iv
chart review of those who have had open, laparoscopic, ureteroscopic, or percutaneous surgery

Conditions: Urologic Diseases

Summary: the investigator intends to review retrospective de-identified data of patients who have had open, laparoscopic, ureteroscopic or percutaneous urologic surgery.

the investigator reviews retrospective de-identified data of patients who have had open, laparoscopic, ureteroscopic or percutaneous urologic surgery in order to determine different clinical or operative issues.

Eligibility criteria:
inclusion criteria: * patients must have had open, laparoscopic, ureteroscopic or percutaneous urologic surgery at ucimc department of urology

Keywords: urologic surgery
prospective database registry study of scoliosis in children with cerebral palsy

Conditions: Cerebral Palsy; Scoliosis

Summary: the purpose of this study is to determine the radiographic and clinical outcomes of scoliosis surgical and non-operative treatment in patients with cerebral palsy.

bracing severe neuromuscular scoliotic curves rarely serves as definitive treatment, thus most progressive curves require surgical intervention in order to sustain or improve sitting (or ambulatory) abilities. surgery is a demanding intervention for these patients, with variable functional gains. controversy persists regarding indications for surgery, timing, and technique. concerns about complications are paramount. previous neuromuscular studies have been confined to a small number of surgeons with a narrow range of surgical instrumentation, technique, and correction. very little evidence exists regarding the impact spinal surgery on the quality of life in children with scoliosis related to cerebral palsy. the instruments to measure quality of life are not specific to children with scoliosis related to cerebral palsy. there have been no comprehensive prospective studies published. this study would be the first large-scale prospective, multi-center series of spinal fusion outcomes in patients with cerebral palsy.

Eligibility criteria:
inclusion criteria: * patient age 8-21 years * diagnosis of cerebral palsy (standard definition of any brain injury before the age of 3) with total body involvement - any functional level * coronal curve \>50 degrees on sitting film (as measured by 'greatest cobb') or kyphotic curve \>70 degrees on sitting film (as measured by t5-t12) and * a spinal fusion is being undertaken and the patient/family is proceeding with the spinal fusion (with any level of distal fusion). or • a spinal fusion is not being undertaken (non-operative cohort) either because the family has refused surgery or because it is not recommended at this point or surgery is recommended but is not being undertaken because they are on a waiting list, and are being enrolled as a non-op patient because they will be on the waiting list for \>18 months. exclusion criteria: * previous operated scoliotic spine deformity * diagnosis of rett's syndrome * concomitant lower extremity surgery (within 3 months of spinal fusion)

Keywords: treatment outcomes scoliosis cerebral palsy