Kornimate/medical-research-clean huggingface dataset:
x-rays trauma request's by the triage and intake nurse intake and referral nurse:

Conditions: Limb Injury

Summary: the number of consultations in emergency departments is increasing day by day, and the time to treat patients is getting longer. different french studies have shown a significant reduction in the time spent in the emergency department after the implementation of the national protocol for the delegation of early radiography prescriptions. the investigators hypothesised that an early request for a standard x-ray by the intake and referral nurse in the case of isolated trauma to the extremities of a limb (from the knee to the toes and from the shoulder to the fingers) enables a reduction in medical management time and, consequently, in the time spent in the emergency department for the patient.

this study is divided into two steps to three month. * the first step of the study corresponds to the current standard of care (soc) in the emergency department of orléans. in this first step, the intake and referral nurse (irn) will carry out the usual triage and refer the participant to the appropriate emergency department before being appointed by the physician. the radiography will be requested after the medical consultation. * in the second step, the intake and referral nurse will carry out the usual triage and then request one, or more, radiography(ies) depending on the standard protocol. this ensures that the physician has access to the imaging before the consultation with the patient. if necessary, the x-ray technician is authorized to refuse the exams or complete the request, the choice of the incidence is up to him/her according to the intake and referral nurse.

Eligibility criteria:
inclusion criteria: * patient older than 15 years and 3 months admitted in adult emergency department of regional hospital center of orleans with a simple and isolated trauma having occurred less than 48 hours prior to admission of a limb extremity (from the knee to the toes or from the shoulder to the fingers), and with no previous imagery assessment within 48 hours prior to admission in the emergency department. exclusion criteria: * multiple trauma * patient with at least one vittel criteria (except age) * patient refusing the protocol * hemodynamic instability and/or disorder of consciousness * sensory and/or vascular disorders downstream of the traumatized area * protected population (under guardianship or curators) * patient under court protection * pregnant or breastfeeding woman or one who declares herself to be pregnant or breastfeeding * patient with an expired blood alcohol level \> 0.4 mg/l and/or positive blood alcohol level * patient with diagnosed dementia * patient hospitalized after being taken in charge

Keywords: traumatology personnel delegation nurse specialists radiography emergency department intake and referral nurse
comparison between anterior approach (deltopectoral) and lateral approach (deltoid splitting) in shoulder reverse arthroplasty for proximal humerus fracture

Conditions: Humeral Fracture; Aged Patient; Reversed Total Shoulder Arthroplasty; Surgical Approach

Summary: the aim of the study consists in comparing two surgical approaches (deltopectoral versus lateral deltoid splitting) in the treatment of proximal humerus fractures treated with a reversed total shoulder arthroplasty the assessment will focus on clinical (clinical scores, efficacy, safety...) and radiological results, between these two types of surgical approaches by using a prospective, randomized analysis.

the 2 main surgical approaches in total shoulder arthroplasty (tsa) are the anterior approach (deltopectoral) and the lateral one (deltoid splitting) (18). their advantages and drawbacks have not been clearly evaluated in proximal humerus fracture treated with an arthroplasty. the goal of the study is to compare the results between patients (older than 65yo) presenting a proximal humerus fracture treated with a reversed shoulder arthroplasty performed through an anterior approach or a lateral one.

Eligibility criteria:
inclusion criteria: * patient older than 65yo with a proximal humerus fracture (neer 3-4 and 2 dislcated) * patient registered to the national health system * patient able to understand information about the protocol and answer to questionnaire exclusion criteria: * non-displaced fracture or no need of surgical treatment. * existing bone disease * infection * neurological deficit (axillary nerve) * multi-injured patients * patient no able to fulfill the questionnaire * patient refuses the study

Keywords: prospective randomized study proximal humerus fracture surgical treatment
targeting interventions at venues where risk of hiv transmission is high

Conditions: HIV

Summary: the aim of this study is to investigate whether distribution of condoms and condom demonstrations by youth peer educators in venues where people meet new sexual partners in livingstone, zambia, leads to increased condom use among guests socializing in these venues.

in countries where the hiv prevalence is high, focusing on high risk places such as venues where people meet new sexual partners is probably more effective in reducing the transmission rate of hiv than targeting interventions just at perceived high risk groups. a survey conducted in 2005 in places where people met new sexual partners in livingstone found that guests socializing there were engaging in high risk sex, but condoms were not always available in the venues. in this intervention study, youth peer educators will distribute condoms and demonstrate condom use in venues where people meet new sexual partners. after the intervention has run for a year, condom use among guests socializing in such venues in the intervention township will be compared with condom use among people socializing in similar venues in a comparison township.

Eligibility criteria:
inclusion criteria: * socializing in a venue where people are said to be meeting new sexual partners * age 18 years and above exclusion criteria: * too drunk to give sensible answers

Keywords: hiv prevention condom distribution youth peer education high risk places condom use prevention through increased condom use
headache in juvenile onset systemic lupus erythematosus

Conditions: Headache; Juvenile Systemic Lupus Erythematosus

Summary: the aim of our study was to compare individuals with juvenile onset systemic lupus erythematosus with and without headache in terms of pain, pain catastrophizing behavior, demographic and individual disease-related factors that may affect headache and temporomandibular joint dysfunction.


Eligibility criteria:
inclusion criteria: * having been diagnosed with juvenile onset systemic lupus erythematosus by the pediatric rheumatology clinic * being between the ages of 8-25, * having stable symptoms and medications * being willing to participate in the study exclusion criteria: * patients with neuropsychiatric disorders not associated with juvenile onset systemic lupus erythematosus (such as history of epilepsy, electrolyte imbalance, or medication side effects) * history of headache before juvenile onset systemic lupus erythematosus diagnosis * presence of another concomitant rheumatic disease * having cognitive impairment to the extent of not being able to cooperate
prognosis of one-stage hepatectomy for bilobar colorectal metastases

Conditions: Liver Metastases

Summary: it is not rare that two-stage hepatectomy for multiple bilobar colorectal liver metastases (clm) be left incomplete because of disease progression or technical reasons. one-stage hepatectomy seems a feasible and safe alternative, however, long-term results are lacking. this study aims to provide evidence that one-stage hepatectomy compelling tumor exposure provides adequate long-term results with low risk of local recurrences.

eligibility criteria the prospectively recruited cohort of patients herein analysed is the result of a policy for which those patients considered resectable and presenting 4 or more lesions, bilobar clm were systematically approached in a one stage operation. patients were considered unresectable once there was concomitance of more than 3 lung metastases, diffuse peritoneal carcinomatosis, and/or extra-hilar lymph node metastasis. outcome measures the primary outcome was the feasibility on an intention-to-treat basis. to this purpose we studied the ratio between the number of patients surgically explored and those who effectively received resection. the secondary outcome was the safety of the procedure. to this purpose we studied morbidity, mortality, amount of blood loss, rate of blood transfusions, and postoperative trend of liver function tests. the tertiary outcome measure was the reliability of the procedure from an oncological standpoint. for this purpose we studied the following: 1. the rate of true local recurrence (cut-edge) after a minimum follow-up of 6 months; 2. the long-term follow-up, analysing the overall survival (survival after surgery), time to recurrence (survival without recurrence), and time to liver recurrence (survival without liver recurrence). 3. the overall survival compared with that based on an intention-to-treat criterion also including the outcome of those patients who met the inclusion criteria but resulted unresectable on exploration.

Eligibility criteria:
inclusion criteria: those patients considered resectable and presenting 4 or more clm, involving both liver lobes are systematically approached in a one stage operation. exclusion criteria: patients carriers of more than 3 lung metastases, and/or diffuse peritoneal carcinomatosis, and/or extra-hilar lymph node metastasis

Keywords: liver metastases surgery intraoperative ultrasound
exploring multiple self-help interventions to promote self-efficacy and overcome disability

Conditions: Ulcerative Colitis (UC); Crohn Disease (CD)

Summary: empower-ibd aims to identify behavioral interventions to strengthen patients' self-efficacy for self-management as a mechanism to reduce ibd-related disability. this multisite, randomized controlled trial with 16 arms will randomize adults with moderate-to-severe ibd-related disability to a combination of four multimodal behavioral interventions to test their clinical effectiveness in reducing ibd-related disability and improving self-efficacy. the interventions are four existing, publicly available disease-specific self-help resources offered at no cost to the participants: a book, smart app, help center, and peer mentor. participants will complete online surveys and may engage in virtual focus groups. participants may receive an honorarium (e-gift card) and/or be entered into a lottery for a giftcards post-survey completion and focus group participation.


Eligibility criteria:
inclusion criteria: 1. adults (age ≥ 18 years) with ibd and moderate-to-severe ibd-related (ibd) disability index score \> 35 26,27) 2. able to consent, complete surveys, and participate in focus groups in english. exclusion criteria: 1. no/low disability (ibd-di \< 35) on the baseline survey 2. inability or unwillingness to participate in the interventions 3. inability to download apps from the apple appstore or google play store (necessary to engage with the smartapp intervention) 4. limited english proficiency (necessary because some interventions are currently only offered in english)
knee malalignment and thigh muscle strengthening in individuals with medial knee arthritis

Conditions: Knee Osteoarthritis

Summary: to investigate the effects of quadriceps strengthening on the adductor moment in individuals with medial knee oa and whether quadriceps strengthening has a different effect on the adductor moment in individuals with and without knee malalignment

although quadriceps strengthening is the cornerstone of physiotherapy management, recent evidence suggests that high quadriceps strength in patients with malaligned knees may increase oa progression. this study investigates the effects of quadriceps strengthening on the adduction moment in patients with medial knee oa with and without malalignment. 107 participants with and without varus knee malalignment were recruited and randomised into an exercise or a control group. participants in the exercise group were taught five quadriceps strengthening exercises by a project physiotherapist to be performed five days a week for twelve weeks at home. the exercises were: 1. quadriceps exercise over fulcrum using ankle weight 2. straight leg raise exercise using ankle weight 3. long arc knee extension exercise in sitting using ankle weight 4. knee extension exercise with isometric hold at 60° knee flexion using ankle weight 5. knee extension exercise with isometric hold at 60° knee flexion using an elastic band. each exercise was performed at 2x10 repetitions for the first 2 weeks and 3x10 repetitions thereafter. participants visited the physiotherapist 7 times at week 1, 2, 3, 4, 5, 7 and 10. they were given the ankle weights and elastic band to bring home and instructed about the repetitions and weights to use by the physiotherapist, who also checked and progressed their exercises. the average duration of the physiotherapy sessions was 30 minutes. to monitor compliance, each participant was given an exercise instructions sheet and kept a training diary to record the exercises they had done. the control group received no intervention.

Eligibility criteria:
inclusion criteria: * pain in the knee * osteophytes on knee x-ray * self-reported pain on the inner aspect of the study knee * osteophytes in the medial compartment of the knee joint and * medial joint space narrowing greater than lateral joint space narrowing on x-ray exclusion criteria: * knee surgery within the previous 6 months * history of lower limb joint replacements * systemic arthritic conditions such as rheumatic or psoriatic arthritis * valgus knee deformity (\> 5º) * inability to walk without the use of walking aids * intending to start a lower limb strengthening program in the next 3 months * seeking or currently receiving physiotherapy for oa knee

Keywords: musculoskeletal diseases joint diseases
a giant myelolipoma.

Conditions: Adrenal Myelolipoma

Summary: 48-year-old woman who presented with intermittent left flank pain with incidental findings of adrenal tumor on computed tomography (ct). she underwent laparoscopic tumor resection due to a large tumor of 12 cm in size.

a 48-year-old female presented to our hospital with the following medical conditions: she denies smoking and drug addiction. type 2 diabetes mellitus under treatment with metfomin, surgical history of abdominal hysterectomy and open cholecystectomy. the patient started experiencing pain located in the left flank for 2 months, which was intermittent, yielded to the administration of analgesics, she denied hematuria and weight loss. on physical examination, the abdomen was distended due to adipose tissue, normal bowel sounds were auscultated, and abdominal masses are not palpable. she underwent a computed tomography (ct) scan. ct features in the anatomical site of the left adrenal gland, a well-defined ovoid tumor is observed, with heterogeneous content with areas of hypodense (5 hu), fat and calcification. it measures 90 x 69 x 92 mm. upon application of contrast medium, the hypodense parts present enhancement up to 44 hu. (fig. 1, 2). she was decided for surgical resection of the tumor via laparoscopic transabdominal approach. the surgery went well without any intraoperative and postoperative complications. she was discharged after day 3.

Eligibility criteria:
inclusion criteria: * patient with myelolipoma exclusion criteria: * patient without myelolipoma

Keywords: benign, neoplasms, adrenal myelolipoma
testing a new device to advance the use of social skills training with mental health consumers and clinicians

Conditions: Schizophrenia Spectrum and Other Psychotic Disorders

Summary: this study aims to test a new device called the social skills coach that is being created to help mental health consumers with social skills and community functioning. people diagnosed with schizophrenia and clinicians will be included as participants in this study. mental health consumers (diagnosed with schizophrenia) will be randomly assigned to either test the new device or to participate in a social skills training course. data will be collected from participants through surveys before participants either use the device or participate the course and afterwards. individual interviews will be conducted with a sub sample of mental health consumers and clinicians. the study looks to test the credibility and acceptability of the new device to help mental health consumers and clinicians. it will also influence future research.

this phase i pilot study tests the feasibility, credibility, and acceptability of the prototype version of social skills coach in terms of its use among mental health consumers and clinicians. the intervention aims to improve social and daily living skills and community functioning among people diagnosed with schizophrenia spectrum disorder. a mixed methods approach will be taken to collect quantitative data at baseline and follow-up. quantitative data collection includes the use of surveys that comprise validated instruments. qualitative data collection will occur at the end of the study and will include the use of semi-structured interviews to capture experiential information. study participants will be randomly assigned to either a social skills training course (control group) or to a study arm using the social skills coach program (treatment group). the study aims to demonstrate proof of concept for a larger effectiveness trial.

Eligibility criteria:
inclusion criteria: * chart diagnosis of schizophrenia spectrum disorder, ability to provide consent, and independent living in the community. * we will obtain written informed consent, and the consent procedure will include an evaluation of capacity to provide consent exclusion criteria: * under age 21 or not able to provide consent.

Keywords: mental health consumers
efficacy and safety of ykp10811 in subjects with irritable bowel syndrome with constipation

Conditions: Irritable Bowel Syndrome; Constipation

Summary: this trial is to investigate efficacy and safety of ykp10811 in subjects with irritable bowel syndrome with constipation. the difference of responder rate between test group (10, 20 and 40mg) and placebo will be evaluated.


Eligibility criteria:
inclusion criteria: 1. more than 18 years old 2. patients met with rome iii criteria for c-type ibs exclusion criteria: * pregnancy or lactation * a history of surgery for gastrointestinal tract * a history of gastrointestinal bleeding, diverticulitis and ileus within 1 year of screening visit * inflammatory bowel disease or malignant tumor within 5 years of screening visit * taking drugs that could have impact on efficacy assessment

Keywords: irritable bowel syndrome constipation c-ibs
safety and tolerability of dupilumab in participants with moderate to severe atopic dermatitis

Conditions: Atopic Dermatitis

Summary: the purpose of this study is to assess the safety and tolerability of repeated subcutaneous (sc) doses of dupilumab in participants with moderate-to-severe atopic dermatitis (ad).


Eligibility criteria:
inclusion criteria: 1. male or female, 18 years or older; 2. chronic ad diagnosed by the eichenfield revised criteria of hannifin and rajka that had been present for at least 3 years before the screening visit; 3. eczema area and severity index (easi) score ≥ 12 at the screening and baseline visits; 4. investigator's global assessment (iga) score ≥ 3 at the screening and baseline visits; 5. ≥ 10% body surface area (bsa) of ad involvement at the screening and baseline visits; 6. history of inadequate response to a stable (≥ 1 month) regimen of topical corticosteroids or calcineurin inhibitors as treatment for ad within 3 months before the screening visit. exclusion criteria: 1. positive hepatitis b surface antigen, and/or positive hepatitis c antibody at the screening visit; 2. treatment with an investigational drug within 8 weeks or within 5 half-lives, if known, whichever is longer, before the baseline visit; 3. treatment with leukotriene inhibitors within 4 weeks before the baseline visit; 4. treatment with systemic corticosteroids within 4 weeks before the baseline visit; 5. treatment with topical corticosteroids, tacrolimus, and/or pimecrolimus within 1 week before the baseline visit; 6. systemic treatment for ad with an immunosuppressive/immunomodulating substance within 4 weeks before the baseline visit; 7. chronic or acute infection requiring treatment with oral or iv antibiotics, antivirals, or antifungals within 4 weeks before the screening visit or superficial skin infections within 1 week before the screening visit; 8. known history of human immunodeficiency virus (hiv) infection; 9. history of clinical parasite infection, other than treated trichomoniasis; 10. history of malignancy within 5 years before the baseline visit, with the following exceptions: participants with a history of completely treated carcinoma in-situ of cervix, and non-metastatic squamous or basal cell carcinoma of the skin were allowed; 11. any medical or psychiatric condition which, in the opinion of the investigator or the sponsor's medical monitor, would place the participant at risk, interfere with participation in the study, or interfere with the interpretation of study results; 12. pregnant or breast-feeding women; 13. unwilling to use adequate birth control, if of reproductive potential and sexually active.
immunotherapy using precision t cells specific to multiple common tumor-associated antigen combined with transcatheter arterial chemoembolization for the treatment of advanced hepatocellular carcinoma

Conditions: Recurrence Hepatocellular Carcinoma; Advanced Hepatocellular Carcinoma

Summary: objectives: the purpose of this study is to evaluate the safety and efficacy of dendritic cell-precision multiple antigen t cells with transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma. methods： this study designs a novel therapy using dendritic cell-precision multiple antigen t cells. 60 patients will be enrolled. they are randomly divided into transcatheter arterial chemoembolization group and dendritic cell-precision multiple antigen t cells combined with transcatheter arterial chemoembolization group. treatments will be performed every 3 weeks with a total of three periods. the mail clinical indicators are progression-free-survival and overall survival.

a total of 60 patients may be enrolled over a period of 1-2 years.

Eligibility criteria:
inclusion criteria: 1. age 18\~65 years old, male or female 2. signed informed consent 3. diagnosis of hepatocellular carcinoma (hcc), surgery can not be performed but tace treatment can be carried out. 4. the recurrence of hcc was found after the operation without distant metastasis. 5. the eastern cooperative oncology group (ecog) score ≤2 6. child-pugh score of liver function ≤ 9 7. routine blood meets the requirements. exclusion criteria: 1. expected overall survival \< 3 months 2. the tumor size or quantity is not suitable for interventional treatment or portal vein tumor thrombus 3. liver function is childs pugh c 4. had received tace therapy previously or in radiotherapy at present,or taking sola feeney 5. other serious diseases:the heart,lung, kidney, digestive, nervous, mental disorders, immune regulatory diseases, metabolic diseases, infectious diseases, etc. 6. unable or unwilling to provide informed consent, or fail to comply with the test requirements.

Keywords: recurrence hepatocellular carcinoma advanced hepatocellular carcinoma dendritic cell -precision multiple antigen t cells transcatheter arterial chemoembolization