Kornimate/medical-research-clean huggingface dataset:
effects of augmented reality on humans

Conditions: Physical Activity; Mental Status Change

Summary: nowadays, augmented reality (ar) has gained attention but little is known concerning its repercussion in individuals when considering some mental and physiological aspects. therefore, the aim of this study was to investigate the effects of ar glasses on some cognitive and physiological functions in an attempt to determine its safety for workers.

twelve volunteers were tested during two separate randomized sessions: one with ar glasses (arglass) and one in normal condition (normal). participants had two perform different tasks of a 90 minutes total duration. before, during and after these tasks, two feet balance, one foot balance, precision balance, stroop and memory tests were performed. also, heart rate and electromyographic activity of some muscles were recorded. finally a survey was filled to determine, for example fatigue, pain or comfort.

Eligibility criteria:
inclusion criteria: * healthy * bmi \< 27 * physically active * informed consent written form exclusion criteria: * in-habitual fatigue * taking drugs and alcohol more than twice a day * potential psychomotor disease * injury in the preceding 3 months * no healthcare

Keywords: augmented reality fatigue muscle heart rate mental function
growing up formula versus nutritional supplements: effect on catch up growth, micronutrient status, and solid foods intake in toddlers with mild or moderate malnutrition

Conditions: Healthy Toddlers 12-36 Months of Age With Mild or Moderate Malnutrition

Summary: this is a pilot study to test how a growing-up formula (guf) compares to a common nutritional supplement (ns), which is regularly used to help toddlers (ages 12-36 months) gain weight. this study will look at whether guf helps to increase solid food intake for children who are thought to be "picky eaters" and see the effects on growth compared with the ns. to date, it is not clear if gufs help to increase intake of solid foods. participants will be placed into one of the two study arms: enfagrow (guf) or pediasure (standard ns).


Eligibility criteria:
inclusion criteria: healthy toddlers 12-36 months of age with mild or moderate malnutrition will be defined by at least one of the following indicators: 1. weight-for-length z-score between -1.0 and -2.9 for children less than 2 years of age using the who growth standards; or 2. bmi z-score between -1 to -2.9 for children between 2 and 3 years of age using the cdc growth standards; or 3. middle upper-arm circumference (muac) z-scores between -1 to -2.9 using the who growth references; or 4. percentage of median ideal body weight of 70-89% (using the 50th percentile of the aforementioned growth standards). exclusion criteria: * toddlers currently on or with history of tube feeding or with chronic health conditions that influence eating (e.g., food allergies, genetic disorders or developmental disabilities, oral motor difficulties that require sensory or feeding therapy). * toddlers who were born at less than 34 weeks gestation, as they may have lingering feeding challenges. * toddlers with gastroesophageal reflux disease (gerd) requiring medications or hydrolyzed formula or any type of esophageal disorders will be excluded. * toddlers with a history of infant reflux will not be excluded. the pi will make this distinction after a detailed history and record review. * families who do not speak english or spanish in the home. * toddlers with suspected malabsorption or conditions that increased metabolic demands such as congenital heart defects. * toddlers who have a diagnosed allergy to cow's milk. the pi will use their clinical discretion to ascertain patient eligibility.
detection of heart conditions using artificial intelligence

Conditions: Left Ventricular Dysfunction; Heart Failure

Summary: the purpose of this study is to evaluate how eko ai performs in the real world, front-line setting where the availability of sophisticated, expensive diagnostic tools is limited, and where there is a premium on detecting vhd early in its course.

echocardiography is the state of the art for diagnosing vhd. however, without an effective pre-screening tool, many echocardiograms ("echos") are being ordered unnecessarily. a recent study found that greater than 66% of all echos performed in the united states do not alter clinical management, while an additional 4% may be deemed inappropriate altogether. because of this, echos now make up a disproportionately large segment of healthcare expenditure. each year, 1 in 5 medicare enrollees receives an echo at a total cost of $1.2 billion, or 11% of total medicare spending on imaging services. this is compounded by the fact that an estimated 35 million americans live in medically underserved areas, where patients must travel an average of 56 miles to see a specialist and receive an echo. this does not encourage compliance, and only adds to cost, lost working hours, and inconvenience. there is therefore a growing, unmet need for better vhd screening tools. tools that will consistently, reliably, quickly, and cheaply identify vhd when it is early and asymptomatic, when patients can be managed early and appropriately, and when they are at the lowest risk from an intervention. such a tool will have a positive impact on the cost of care, patient and provider experience, and healthcare outcomes. the fda-cleared eko core and eko duo electronic stethoscopes offer clinicians a familiar and inexpensive tool that is widely accepted by patients and providers, while at the same time offer sensors and artificial intelligence technology that can improve screening and detection of medical conditions such as vhd. both the core and the duo feature sound amplification during auscultation - the core also offers active noise cancellation - which improves the ability of the clinician to detect nuanced changes in heart sounds.

Eligibility criteria:
inclusion criteria: * english-speaking adults who are 18 years and older * able and willing to provide informed consent * complete a clinical echocardiogram within 7 days before or after study procedures exclusion criteria: * unwilling or unable to provide informed consent * patients who are hospitalized
open label pharmacokinetic study of sar302503 in subjects with renal impairment

Conditions: Renal Impairment

Summary: primary objective: to study the effect of mild, moderate and severe renal impairment on the pharmacokinetics of sar302503. secondary objective: to assess the tolerability of sar302503 given as a single 300 mg dose in subjects with mild, moderate and severe renal impairment and in matched subjects with normal renal function.

study duration = 17 to 35 days

Eligibility criteria:
inclusion criteria : * male or female subjects, between 18 and 75 years of age, inclusive. * for subjects between ages 75 to 79 with the approval from sponsor's medical monitor. * body weight between 50.0 and 115.0 kg, inclusive if male, and between 40.0 and 100.0 kg, inclusive if female, body mass index between 18.0 and 34.9 kg/m2, inclusive. * stable chronic renal impairment, as defined by cockcroft-gault formula; * laboratory parameters within the acceptable range for subjects with renal impairment. * using a double contraception method. exclusion criteria: * uncontrolled clinically relevant cardiovascular, pulmonary, gastrointestinal, metabolic,hematological, neurological, psychiatric, systemic, ocular, gynecologic (if female), or infectious disease, or signs of acute illness * active hepatitis, hepatic insufficiency * acute renal failure (de novo or superimposed to preexisting chronic renal impairment), nephrotic syndrome * history of or current hematuria of urologic origin that limits the subject's participation in the study * subjects requiring dialysis during the study. * any significant change in chronic treatment medication within 14 days before inclusion. * concomitant treatment with or use of drugs or herbal agents known to be at least moderate inhibitors or inducers cyp3a4, sensitive or narrow therapeutic index substrate of cyp3a4. * concomitant treatment with gastric ph modifying agents (proton pump inhibitors and h2-blockers) is not allowed 7 days prior to and 6 hours after study drug treatment the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
mentalization-based therapy to prevent suicidal behavior in adolescents with bipolar disorder

Conditions: Bipolar Disorder; Suicidal Ideation

Summary: children and adolescents with early-onset bipolar disorder (bd) are at high risk for intentionally hurting themselves. although there are therapies in existence for these youths with bd, they do not address suicide prevention specifically. mentalization-based therapy for adolescents (mbt-a) has been shown to be helpful in reducing self-harm in the adolescent and adult population with borderline personality disorder. the investigators will modify the mbt-a treatment procedures for persons with bd who have had a recent period of suicidal ideation or behavior.

youth with early-onset bipolar disorder (bd) are at an elevated risk for intentional self-harm compared to healthy adolescents or adolescents with other psychiatric disorders. adolescents vulnerable to emotion dysregulation and self-harm often have deficits in the ability to mentalize: to understand, acknowledge, and predict thoughts and feelings in oneself and others. mentalization-based therapy for adolescents (mbt-a) has been shown to be more effective than 'usual care' in reducing self-harm for adolescents and adults with borderline personality disorder. mbt-a includes psychoeducational and coping strategies that may prove quite effective for bipolar adolescents who are at elevated risk for self-harm. participation in this study will last 9 months. all participants will receive a thorough medical-psychiatric evaluation. all youth will be able to receive pharmacotherapy with a study psychiatrist in the champ clinic. the mbt-a will consist of up to 21 weekly, biweekly and monthly individual sessions interspersed with 9 monthly family sessions (30 therapy hours total). participants will also complete follow-up assessments every 3 months for 9 months. these assessments will include research interviews and questionnaires.

Eligibility criteria:
inclusion criteria: * diagnosis of bipolar disorder i, bipolar disorder ii, or bipolar disorder not otherwise specified * living with or in close contact with at least one parent who is willing to participate * have had at least 1 week in the prior 3 months of significant suicidal ideation and/or at least one suicidal event in the 3 months prior to study intake. * willing to be treated pharmacologically by a psychiatrist in the ucla child and adolescent mood disorders (champ) clinic exclusion criteria: * participants requiring immediate hospitalization * diagnosis of borderline personality disorder, schizophrenia, or schizoaffective disorder. * current substance dependence disorder

Keywords: bipolar disorder suicidal depression self-harm psychosocial intervention
feasibility of a rct that compares immediate versus optional delayed surgical repair after acl injury

Conditions: Anterior Cruciate Ligament Injuries

Summary: currently, most patients with an anterior cruciate ligament (acl) injury undergo surgery. there is a general belief that surgical reconstruction is necessary to return to sport safely and to limit premature knee osteoarthrosis or additional meniscal damage. however, there is unsufficient scientific evidence for this belief. moreover, several studies show that a reconstruction does not guarantee successful return to sports or the prevention of osteoarthritis or meniscal injuries at all. therefore, an immediate surgery after an acl injury is more and more questioned. the only qualitative rct that exists (kanon trial) could not demonstrate that an immediate reconstruction is an added value (in terms of symptoms, knee function, activity level, osteoarthritis or incidental meniscal damage) compared to a conservative approach consisting of progressive rehabilitation and delayed surgery if there was persistent knee instability. in a future multicenter rct the investigators want to 1) verify these results and 2) search for predictors that predict which patients from the conservative group do well without delayed surgery. this information is invaluable to physicians as it allows them to decide which treatment is best for the patient. before performing a large, adequately-powered rct that compares both treatment options, the investigators will run a pilot study that assesses the feasibility to recruit acl patients for such rct. this seems necessary, as many patients still believe that timely surgery is a prerequisite for restoring knee function, for returning to sports and for preventing cartilage degeneration. these preferences for surgery might affect recruitment and adherence to the protocol. therefore, a pilot study will performed that demonstrates whether a large rct is feasible with regard to 1) participant recruitment, 2) adherence to the treatment arm they were allocated to and 3) protocol feasibility. the findings of this pilot study will help deciding about progressing to a future definitive rct.


Eligibility criteria:
inclusion criteria: * rotational trauma to a previously uninjured knee within the preceding 4 weeks * medical diagnosis of acl insufficiency including mri (both partial and complete ruptures) * minimum of 18 years exclusion criteria: * patient has history of a previous acl injury or knee surgery to the index knee. * indication for acute surgery because of related injuries to the knee * any disorder, which in the investigator's opinion might jeopardise participant's safety or compliance with the protocol. * female who is pregnant. since mri assessment cannot be performed.
comparison of sub-maximal voluntary isometric training vs eccentric training in management of de quervain tenosynovitis

Conditions: De Quervain Syndrome

Summary: this study is a randomised control trial and the purpose of this study is to compare the effects of sub-maximal voluntary isometric training vs eccentric training in management of de quervain tenosynovitis

participants will be recruited into their respective groups using a coin toss method. de quervain tenosynovitis will be assessed using the following tests: 1. wrist hyperflexion and abduction of thumb (what) test 2. finkelstein's / eichhoff's test 3. de quervain screening tool

Eligibility criteria:
inclusion criteria: * patients having history of pain, tenderness in thumb region from 3 weeks or more * age 21-50 * both genders * individuals meeting the diagnostic criteria i.e. * a score of 3 or more out of 7 on de quervain screening tool. * positive wrist hyperflexion and abduction of thumb (what) test * positive finkelstein's / eichhoff's test exclusion criteria: * diagnosed cases of osteoarthritis of 1st cmc joint and rheumatoid arthritis * c6 cervical radiculopathy * any systemic inflammatory condition like septic arthritis * carpal tunnel syndrome * complex regional pain syndrome * previous surgery impacting the first extensor compartment of the wrist * corticosteroid injection in the radial wrist region within 3 months of enrolment into the study * if patient had undergone isometric thumb exercises or any strengthening protocol lasting greater than 2 weeks for the management of their current episode of de quervain's syndrome
efficacy of biofortified maize to improve maternal and infant vitamin a status

Conditions: Vitamin A Deficiency

Summary: the purpose of this randomized control trial is to test the impact of provitamin a carotenoid biofortified maize meal consumption on maternal and infant vitamin a status.

vitamin a deficiency remains a major public health problem in low and middle income countries. approximately 50% of zambian children are thought to be affected. this randomized control trial will test the efficacy of provitamin a carotenoid biofortified maize meal consumption as a strategy to improve vitamin a status among lactating zambian mothers and their infants. the investigators will enroll up to 255 mother/infant pairs to a three-month study, during which they will receive one of the following three interventions: 1) conventional white maize, 2) provitamin a carotenoid biofortified orange maize, or 3) preformed vitamin a fortified white maize.

Eligibility criteria:
inclusion criteria: * singleton birth * no birth defects * free from chronic health conditions * infant received 100,000 iu vitamin a at 6 months of age * currently breastfeeding * not pregnant at 9 months post partum * hemoglobin \> 8.0 g/dl for women and \> 7.0 g/dl for infants exclusion criteria: * multiple birth * birth defects * any chronic health condition requiring regular medical visits * infant did not receive vitamin a capsule at 6 months of age * no longer breastfeeding * pregnant * hemoglobin ≤ 8.0 g/dl for women or ≤ 7.0 g/dl for infants
the study of potency of cross-preconditioning to prevent ischemic-reperfusion injury for heart transplantation recipient

Conditions: Ischemic Preconditioning

Summary: in recent years, a large number of studies confirmed the protective effect of ischemic preconditioning on myocardium against ischemia/reperfusion injury, but the clinical data of the effectiveness of ischemic preconditioning in heart transplantation is still missing. inspired by the promising data of ischemic preconditioning from the previous reports, the investigators firstly introduce a novel method of cross ischemic preconditioning technique to prevent ischemia/reperfusion injury to heart transplant recipients. this study will evaluate whether this cross-preconditioning technique would attenuate ischemia/ reperfusion injury to the heart transplant recipients, reduce intensive care unit(icu) and total hospitalization stays and the incidence of cardiovascular adverse events and improve the long-term survival outcomes.

patients receiving heart transplantation are randomly assigned into the cross ischemic preconditioning (cicp) intervention group and the control group. (the statistical analysis system (sas) software was used to generate a random number table and randomly divided into two groups). after the establishment of the cardiopulmonary bypass, the ascending aorta of the cicp group will be crossclamped 2 minutes, separated by a 3-minute rest interval, and repeated successively on 2 occasions. the recipients in the control group are to undergo routine cardiopulmonary bypass procedure of heart transplantation.

Eligibility criteria:
inclusion criteria: 1. patients who underwent heart transplantation； 2. signed informed consent. exclusion criteria: 1. systemic active infection; 2. refractory respiratory failure or renal failure; 3. severe systemic diseases with limited survival time. 4. abo blood groups incompatibility 5. positive serum hiv antibody; 6. drug or alcohol abusing; 7. mentally ill; 8. recent history of severe pulmonary embolism 9. have not signed informed consent.

Keywords: heart transplantation ischemia-reperfusion injury
safety and efficacy of two vaginal products versus placebo in patients with vaginal discomfort

Conditions: Vulvodynia

Summary: this study will evaluate the efficacy and safety of two vaginal products compared with that of placebo to determine if the two products are better than placebo in the relief of vaginal discomfort.


Eligibility criteria:
inclusion criteria: * patients must have sought doctor's care for this condition. * patients must be having menstrual cycles. exclusion criteria: * patients must not have any vaginal infections. * patients must not be pregnant or nursing. * must not be receiving any other medicinal therapies or any medications that would interfere with the outcome of the study.
acquisition of cardiac function parameters in mri and echocardiography in patients with ethyltoxic liver cirrhosis and transjugular intrahepatic portosystemic shunt (tipss) placement

Conditions: MASLD; Liver Cirrhosis, Alcoholic; Cirrhosis of Liver; Heart Decompensation; TIPS

Summary: the aim of this clinical trial is to investigate the development of cardiac decompensation following transjugular intrahepatic portosystemic shunt (tipss) implantation in order to draw conclusions for future treatment methods or exclusion criteria prior to tips implantation. the main questions to be answered are: how often do symptoms of cardiac decompensation develop over a one year period? what laboratory, clinical or imaging morphological changes are associated with this? in addition to the standardised clinical procedure for tipss implantation, participants will undergo 3 cardiac magnetic resonance imaging (mri), extended echocardiographic examinations (both just before, 3 days after and 3 months after implantation) and laboratory chemistry tests for specific endothelial and inflammatory markers (just before, on the day of implantation, 1 day after, 1, 3, 6 and 12 months after implantation).


Eligibility criteria:
inclusion criteria: * age 18 to 99 years * written informed consent of the patient * decompensated liver cirrhosis, defined by clinical, imaging or laboratory criteria * patient receives an elective tipss in the appropriate clinical context at the juh exclusion criteria: * pregnancy * implants not suitable for magnetic resonance imaging * medical/personal reasons against magnetic resonance imaging (claustrophobia, patient cannot lie flat or follow breathing commands) * patient in critical condition or incompliant

Keywords: chirrotic cardiomyopathy liver chirrosis tips
efficacy of electrical vestibular nerve stimulation (vens) in the management of obesity: a randomized clinical trial

Conditions: Obesity

Summary: the aim of this study is to observe the efficacy of electrical vestibular nerve stimulation in the management of obesity. allocation: active device (participants act as their own self-control) endpoint classification: efficacy study. the study provides further evidence for the efficacy of electrical vestibular nerve stimulation in the management of obesity.


Eligibility criteria:
inclusion criteria: * bmi 30 to 40 kg/m2 * aged above 18 years exclusion criteria: * current use of any medications or therapy including use of oral contraceptives * use of dietary supplements known to affect the bmi * ear problems (assessed during physical examination) * any severe complications * unwilling participants