Kornimate/medical-research-clean huggingface dataset:
polymorphism c677t mthfr and effects of folate intake

Conditions: Overweight and Obesity

Summary: the c677t polymorphism in the mthfr gene is related to several significant biochemical changes, as dyslipidemia, changes in serum levels of homocysteine, folic acid, vitamin b12 and some oxidative stress markers such as the cat and mda, leading to a high risk of the emergence of cardiovascular disease (cvd). a diet containing antioxidants, especially folate, is characterized by being beneficial for individuals with this genetic alteration to possess anti-inflammatory function, act on and oxidative stress play an important gene function. the aim of this study was to evaluate the influence of the c677t polymorphism of the mthfr gene and the effect of a diet containing folate on oxidative stress, lipid profile and homocysteine levels in adult women are overweight or obese. this is an intervention study, double-blind, held in a city in northeastern brazil. the study included 48 adult women (20-59 years old) with bmi of 26.19 kg / m² and 49.64 kg / m², in which we evaluated the cat levels, mda, lipid profile, folic acid, homocysteine and vitamin b12 addition genotyping for the c677t polymorphism in the mthfr gene and the food consumption by the food recall 24 hours, being divided by randomization into two groups received daily for 8 weeks, 300g vegetables rich in folate containing 191 ug and 90 ug of this nutrient.

this work is linked to a population-based survey entitled "diagnosis and intervention ii cycle situation food, nutrition and noncommunicable diseases prevalent over the city of joão pessoa population / pb" (ii disandnt / pb). for the realization of this dissertation home visits and the questionnaires related to anthropometric and food intake assessment were conducted by teams of undergraduate researchers and graduates of nutrition course, masters and doctoral students of the post graduate program in nutrition sciences (ppgcn) of ufpb duly previously trained at the beginning of data collection and after completion of the pilot study. after the selection of individuals from the sample of adults who participated in the ii disandnt / jp and considering the inclusion criteria and genotyping of the c677t polymorphism in the mthfr gene, they were invited to participate.

Eligibility criteria:
inclusion criteria: * adult women, aged 20 to 59, sound overweight or obese * individuals of different socioeconomic conditions * users or not drugs * cognitive state preserved and accept participate exclusion criteria: * drinkers, smokers or neuropsychiatric disorders * users drugs known to interfere with the metabolism of folic acid (the last 3 months), as prednisone, hydrocortisone, dexamethasone, chloramphenicol, acetylsalicylic acid * multivitamin supplement users, minerals, appetite suppressants and steroids * individuals with chronic diseases with influence on the endocrine and metabolic system * pregnant or planning to become pregnant during the study period

Keywords: polymorphism folate oxidative stress overweight and obesity
effect of heavy smoking on hard and soft tissue parameters prospective clinical trial

Conditions: Dental Implants,Peri-implantitis,Smoking

Summary: the aim of this study randomized prospective clinical trial is to examine and compare periimplant tissue changes between heavy smokers and non-smokers at 12 months post loading using the alpha bio neo standard diameter implants with conical abutment.

peri-implant marginal bone level is one of the most important references criteria to monitor peri-implant health.a radiographically measured marginal bone loss of up to 1.5 mm during the first year of loading, followed by a marginal bone loss of up to 0.2 mm for each succeeding year, is an acceptable criterion to determine implant success. smoking has been implicated in many adverse systemic outcomes, including tooth loss, alveolar bone loss and dental implant failure. platform switching, also known as platform shifting, is whenever an abutment is used that is smaller in diameter than the implant platform. platform switching can help prevent crestal bone loss. the hypothesis of the present study is that the use of conical abutment might reduce marginal bone loss around dental implants in both smokers and non-smokers alike.

Eligibility criteria:
inclusion criteria: 1. age between 20 - 85 years. 2. written informed consent. 3. in need for a dental implant adequate alveolar bone intended to be restored with individual crowns. 4. heavy smokers (20 cig/d \> 5years) or non / former smokers (\> 5 years since cessation). exclusion criteria: 1. active periodontal disease. 2. systemic condition and medication that may affect soft and hard tissue. 3. healing parafunctional occlusal scheme and habits. 4. pregnancy or intention to become pregnant in the following twelve months. 5. patient not willing or able to meet the study schedule. 6. patient in need for simultaneous bone graft or gbr using a membrane barrier.
trial of the effectiveness of a nurse education and care program for breast cancer patients treated with chemotherapy

Conditions: Breast Cancer

Summary: the purpose of this study is to evaluate the effects of a nurse education and care program for patients with breast cancer, in terms of use of the health services, quality of life, satisfaction and security. hypothesis: nurse education and care program will reduce the use of health resources and will improve the toxicity, quality of life and satisfaction of the patients with breast cancer who initiate chemotherapy.

design: randomized controlled clinical trial with non-pharmacologic intervention. subjects and setting of study: patients with breast cancer who initiate adjuvant, neoadjuvant or palliative chemotherapy, in the day unit of a university hospital. interventions: random allocation of the patients in two arms according to the nursing cares. the arm a is the one of standard education and care. they consist of receiving programmed oral and written information by the specialist in medical oncology before initiating the chemotherapy treatment and before each cycle of treatment. also, the patients will be able to ask for information to the nurses when they need it. arm b is the one of experimental education and care. they consist of receiving oral and written information by the specialist before initiating the chemotherapy treatment and before each cycle. in addition, the patients assigned to arm b will receive programmed education and care about the chemotherapy by a nurse of the medical oncology service before the beginning of the treatment and in each cycle, in a specific nurse consultation. determinations: use of health resources (not programmed attendance in primary, specialist and emergency care or hospitalisation). toxicity caused by the chemotherapy. patients who leave the chemotherapy by serious toxicity. quality of life measured by means of the eortc qol-c30 questionnaire. satisfaction with the received medical assistance.

Eligibility criteria:
inclusion criteria: * patients with breast cancer who initiate adjuvant, neoadjuvant or palliative chemotherapy. * performance status 0-2 (ecog). * outpatients. * normal hematopoietic, hepatic, renal, cardiac and lung functions. * must be able to sign the informed consent exclusion criteria: * contraindication for chemotherapy * inpatients * simultaneously radiotherapy and endocrine therapy.

Keywords: quality of life breast cancer nursing care education chemotherapy
oral anticoagulation in hemodialysis

Conditions: Atrial Fibrillation

Summary: the investigators refer to the trial with clinicaltrials.gov indentifier nct02610933 entitled effect on vascular calcification of replacing warfarin by rivaroxaban with or without vitk2 in hemodialysis patients. after termination of this trial, included patients will be asked to participate in the extension trial by continuing the treament of their respective allocation arm. no new intervention will be done.

the investigators refer to the trial with clinicaltrials.gov indentifier nct02610933 entitled effect on vascular calcification of replacing warfarin by rivaroxaban with or without vitk2 in hemodialysis patients. after termination of this trial, included patients will be asked to participate in the extension trial by continuing the treament of their respective allocation arm. no new intervention will be done. relevant endpoints like death, cardiovascular events and bleeding episodes will be registered.

Eligibility criteria:
inclusion criteria: * inclusion in the trial with clinicaltrials.gov identifier nct02610933 * signed informed consent for this extension trial exclusion criteria: * none

Keywords: hemodialysis rivaroxaban vitamin k2
discount generic prescription study

Conditions: Poverty; Low-Income Population

Summary: the goal of this study is to learn about the factors that influence people to take part in discount generic prescription programs. the primary objective of this study is to identify the factors associated with awareness and utilization of discount generic prescription programs and how two low-income populations in houston utilize the $4 for a 30-day supply or $10 for a 90-day supply, generic prescriptions program offered by kroger, randalls, target, walmart, heb, cvs, and walgreens.

if you agree to take part in this study, you will take part in a focus group. the focus group will consist of about 8 people who will discuss beliefs about generic medication, awareness of discount generic prescription programs, and use of the discount generic prescription program. the focus group will last about 90 minutes. during the focus group, you will complete a form that asks for basic demographic information (such as your age and sex). the focus group discussions will be taped, and the recorded tapes will be transcribed word-for-word. the taped recording of the focus group study will be stored in a safe and secured locker by the study chair. the taped recordings will be destroyed after 5 years. length of study: your participation on this study will end once you complete the focus group. this is an investigational study.

Eligibility criteria:
inclusion criteria: * age 18 and older * low-income (less than $30,000/year) * ability to speak english * ability to read and write in english * chronic health condition requiring prescription medication or family member with chronic health condition requiring prescription medication. exclusion criteria: * none

Keywords: low-income populations chronic health condition prescription medication prescription drugs discount generic prescription programs survey awareness focus group houston
study in subjects with copd (chronic obstructive pulmonary disease)

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: this study was designed to determine if the investigational drug is effective and safe in individuals with copd (chronic pulmonary disease)


Eligibility criteria:
inclusion criteria: * diagnosis of copd and a history of cigarette smoking. exclusion criteria: * significant heart or lung disease not associated with copd. * significant stomach or intestinal disease.

Keywords: smokers cough
hepcidin behavior in patients with obesity and bariatric surgery

Conditions: Hepcidin

Summary: iron deficiency is one of the most common nutritional problems observed in patients with obesity and after bariatric surgery. from a therapeutic point of view, iron deficiency can lead to iron deficiency anemia. iron supplementation carries the risk of exacerbating infections, altering the gut microbiome and iron overload. therefore, it would be beneficial to use iron supplementation only in truly iron deficient patients. to date, different studies have observed that hepcidin could be a possible indicator of iron status and absorption in different patient populations. furthermore, it could be used to distinguish anemia due to iron deficiency from inflammation and globin disorder related anemia. how hepcidin concentrations variate in patients with obesity and after bariatric surgery remains unsure.

during the visit in the obesity clinic, eligible patients will be approached for participation by the sub-investigator. interested patients will receive information regarding the study and receive the information sheet containing the informed consent form. after signing the informed consent form, general information will be collected regarding medical and demographic data using a short questionnaire. additional questionnaires regarding demographics and menstrual cycle will be collected. anthropometric measurements will be collected for the determination of the length, weight, hip circumference, waist circumference and body composition. finally, blood samples will be collected for the determination of iron and inflammation related markers.

Eligibility criteria:
inclusion criteria: * the patient has to be 18 years or older * written informed consent has to be obtained after being informed on all aspects of the study * the patient has a bmi \> 30 kg/m² or there has to be at least one year between the primary rygb and the participation in the study or there has to be at least one year between the primary sg and the participation in the study exclusion criteria: * patients younger than 18 years old * women who are pregnant or are breastfeeding * post-menopausal women, defined as at least 6 months of amenorrhea after the final menstrual period * inability to follow the procedures of the studies due to language problems * patients who have had more than one bariatric surgery
bio-integrative versus metallic screws for calcaneus osteotomies

Conditions: Flatfoot; Bone Resorption; Cavus Deformity; Osteolysis; Complication

Summary: the use of bio-integrative implants in orthopedic surgery is growing exponentially. as many biomechanical and histological studies were able to sustain its structural and biological properties, few clinical studies are available to support its advantages, such as good osteosynthesis, lower rates of removal, and diminished implant-related artifact in imaging studies. this information is vital to providers when choosing the proper material and planning postoperative treatment. this trial intends to test the capacity of the bioabsorbable screws in reaching the same clinical and radiographical outcomes of the current metallic screws.

a minimum of 44 patients undergoing medial or lateral displacement calcaneal osteotomy (mdco) will be randomized in two parallel groups for surgery, considering applied the implant. one group will be operated using two 4.0mm cannulated bio-integrative (absorbable) screws, and the other group using two 4.0mm cannulated metallic screws. patients will be blinded evaluated for a mean follow-up of twelve weeks in terms of bone healing, complications, and implant-related artifact using weight-bearing computed tomography (wbct).

Eligibility criteria:
inclusion criteria: * individuals must be older than 18 and younger than 75 years of age, both genders; * participants must be experiencing symptoms related to their baseline condition for at least six months before the surgery; * clinical diagnosis of hindfoot malignment, defined as the presence of a clinical hindfoot angle above 10 degrees of valgus or any degree of varus; * surgical planning, including a calcaneus displacement osteotomy through a traditional oblique cut. exclusion criteria: * previous surgery involving the affected calcaneus; * history or documented evidence of autoimmune or peripheral vascular diseases; * history or documented evidence of peripheral neuropathy (nervous compression syndrome, tarsal tunnel syndrome) or systemic inflammatory disease a (rheumatoid arthritis, spondylitis, reiter syndrome, etc.); * any condition that represents a contraindication of the proposed therapies; * impossibility or incapacity to sign the informed consent form; * presence of infectious process (superficial on the skin and cellular tissue, or deep in the bone) in the region to be treated. * osteotomies requiring resection of wedges (dweyer, triple dweyer, etc.); * osteotomies planned to occur in a non-traditional cut (malerba, scarf, etc.).

Keywords: bone healing osteotomy calcaneus bio-integrative metallic screws
study of cadonilimab combined with chemotherapy in recurrent / refractory pleural mesothelioma

Conditions: Pleural Mesothelioma

Summary: this is a multicenter, single-arm, phase ii clinical study to evaluate the safety and efficacy of cadonilimab combined with gemcitabine, or vinorelbine, or pemetrexed in the treatment of patients with recurrent / refractory pleural mesothelioma.


Eligibility criteria:
inclusion criteria: 1. histologically confirmed advanced or metastatic pleural mesothelioma; 2. eastern cooperative oncology group (ecog) performance status of 0 or 1. 3. participants must have previously failed to receive platinum-containing chemotherapy with or without bevacizumab, and have received at most two-line systemic therapy. 4. measurable disease as per mrecist v1.1 for assessment of response in malignant pleural mesothelioma. 5. adequate haematological, renal and liver function. exclusion criteria: 1. primary mesothelioma of peritoneum, pericardium and testes 2. active, untreated central nervous system (cns) metastasis. 3. use of chinese herbal medicine or immunomodulatory agents with anti-tumor indications within 14 days prior to the first dose of study treatment. 4. known active autoimmune diseases. 5. presence of other uncontrolled serious medical conditions.

Keywords: cadonilimab pleural mesothelioma bispecific antibody
introduction of mycotic prophylaxis at cystectomy trial.

Conditions: Cystectomy

Summary: this study aims to introduce a perioperative antifungal prophylaxis for patients undergoing cystectomy: surgically removal of the urinary bladder with construction of a urinary diversion. we wish to investigate the effect of antifungal prophylaxis on complications after the operation.

cystectomy with construction of a urinary diversion, is a major cancer surgery and one of the most complex surgeries in the urological specialty. after cystectomy, the most commonly performed urinary diversion is an ileal conduit, where a section of the terminal ileum is shunted out and connected to the upper urinary tract and a stoma is created. during this procedure, the abdominal cavity is exposed to bacteria and fungus from the ileum. besides the perioperative contamination, micro-leakage in relation to the anastomosis is suspected to contribute to a local infectious response that may result in postoperative complications as ileal paralysis. paralytic ileus is a serious complication that affects many patients after cystectomy, resulting in a prolonged length of stay, low quality of life postoperatively, and increased risk of complications such as aspiration, pneumonia, wound rupture, deep venous thrombosis, undernourishment and infections. current guidelines support the use of perioperative antibiotics targeting gram-negative and gram-positive bacteria, typically administered as broad-spectrum medicine such as piperacillin/tazobactam or cephalosporins. regarding fungal infections, emerging data show that 48% of the patients undergoing rc have candida albicans in samples from the terminal ileum. also, it is well known that fungal infections are highly prevalent in patients undergoing gastrointestinal surgery where it is associated with a high risk of mortality. small retrospective studies suggest that the addition of antifungal medicine to perioperative antibiotics can reduce the risk of bowel- and infectious complications after abdominal surgery. the compelling theoretical and clinical rationale for addition of antifungal prophylaxis to standard-of-care antibiotic prophylaxis for patients undergoing radical cystectomy provides the basis for initiation of a randomized clinical trial representing the highest level of evidence.

Eligibility criteria:
inclusion criteria: * patients 18 years and older * willingness to participate in the study and the ability to understand and sign an informed consent * indication for performing cystectomy * the urinary diversion is limited to the ileal conduit exclusion criteria: * patients with contraindications to fluconazole. this includes allergies and treatment with non-pausable medication that in combination is contraindicated * patients in active treatment for mycotic infections
laparoscopic ventral mesh rectopexy combined with or without stapled trans-anal rectal resection for obstructed defecation syndrome

Conditions: Obstructive Defecation Syndrome; Chronic Constipation; Rectal Prolapse

Summary: obstructed defecation syndrome (ods) is a common problem in women. rectal prolapse and rectocoele are frequently identified in patients with ods. surgery is the only definite treatment for those patients and is preferably performed minimally invasive. the most used procedures are laparoscopic ventral mesh rectopexy (lvmr) and stapled trans-anal rectal resection (starr). however, high-level prospective studies on treatment strategies for ods currently are lacking and, thus, no consensus exist regarding the optimal treatment for patients with ods. this study aimed to compare lvmr alone and lvmr combined with starr evaluating functional and anatomical results.


Eligibility criteria:
inclusion criteria: * patients affected by obstructed defecation with a minimum ods score of 10 * external rectal prolapse or high-grade internal rectal prolapse * often experience excessive straining, sense of incomplete evacuation, and/or prolonged time for complete evacuation when attempting a bowel movement * have experienced ods symptoms for at least 12 months prior to enrollment * failure of at least 6 months of medical therapy * american society of anesthesiologists (asa) score of no more than 3 exclusion criteria: * slow transit constipation * anismus resistant to conventional treatment * no demonstrable pelvic anatomical problem * previous rectal or anal surgery * recto-vaginal fistula * pregnancy * previous pelvic radiotherapy * severe proctitis or significant rectal fibrosis * evidence of colorectal neoplasia, carcinoma, or inflammatory bowel disease * perineal infection * high-grade endometriosis * morbid obesity * a hostile abdomen * psychological instability