Kornimate/medical-research-clean huggingface dataset:
amyloid prediction in early stage alzheimer's disease from acoustic and linguistic patterns of speech - future extension

Conditions: Alzheimer Disease; Preclinical Alzheimer's Disease; Prodromal Alzheimer's Disease; Alzheimer's Disease (Incl Subtypes); Mild Cognitive Impairment

Summary: the primary objective of the study is to evaluate whether a set of algorithms analysing acoustic and linguistic patterns of speech, can predict change in pacc5 between baseline and +12 month follow up across all four arms, as measured by the coefficient of individual agreement (cia) between the change in pacc5 and the corresponding regression model, trained on baseline speech data to predict it. secondary objectives include (1) evaluating whether similar algorithms can predict change in pacc5 between baseline and +12 month follow up in the cognitively normal (cn) and mci populations separately; (2) evaluating whether similar algorithms trained to regress against pacc5 scores at baseline, still regress significantly against pacc5 scores at +12 month follow-up, as measured by the coefficient of individual agreement (cia) between the pacc5 composite at +12 months and the regression model, trained on baseline speech data to predict pacc5 scores at baseline; (3) evaluating whether similar algorithms can classify converters vs non-converters in the cognitively normal arms (arm 3 + 4), and fast vs slow decliners in the mci arms (arm 1 + 2), as measured by the auc, sensitivity, specificity and cohen's kappa of the corresponding binary classifiers. secondary objectives include the objectives above, but using time points of +24 months and +36 months; and finally to evaluate whether the model performance for the objectives and outcomes above improved if the model has access to speech data at 1 week, 1 month, and 3 month timepoints.


Eligibility criteria:
inclusion criteria: * subjects are fully eligible for and have completed the amypred (amyloid prediction in early stage alzheimer's disease from acoustic and linguistic patterns of speech) study. (see https://clinicaltrials.gov/ct2/show/nct04828122) * subject consents to take part in future extension study. exclusion criteria: * subject hasn't completed the full visit day in the amypred study.

Keywords: alzheimer's disease preclinical alzheimer's disease prodromal alzheimer's disease mild cognitive impairment normal cognition amyloid speech acoustic language linguistic machine learning artificial intelligence
effect of acupressure on carpal tunnel syndrome in pregnant women

Conditions: Carpal Tunnel Syndrome

Summary: this study will be conducted to investigate the effect of acupressure on carpal tunnel syndrome in pregnant women.

the pregnant women are more prone to develop carpal tunnel syndrome because they retain more fluid during the later stages of their pregnancies. the more fluid retained , the more swelling occurs , squeezing the nerves that run through the hand and finger. also most women who experience pain, numbness and tingling in the hand for the first time due to pregnancy have no idea that they have carpal tunnel syndrome. given the importance of treating cts and preventing the limitations caused by this syndrome, and since it can turn into a debilitating disease if left untreated, acupressure can be recommended as a safe and noninvasive technique for reducing the severity of clinical symptoms. till now, there is no previous studies explored the effect of acupressure on carpal tunnel syndrome in pregnant women. so, this study will be conducted to provide new information about the efficacy of acupressure in management of carpal tunnel syndrome in pregnant women, which will help such pregnant women to overcome this problem and will add new evidence to the field of physical therapy.

Eligibility criteria:
inclusion criteria: * pregnant women who are clinically diagnosed as having carpal tunnel syndrome . * their age will be ranged from 20 to 35years old. * their body mass index will not exceed 30kg/m2. * all of them are in their 3rd trimester of pregnancy.(28-40weeks) * all of them suffer from mild and moderate cts. * degree of carpal tunnel pain will be 2 or more on visual analogue scale. exclusion criteria: * dermatological abnormalities in the skin of acupionts. * internal fixation at the area of acupressure application. * smokers . * metabolic diseases such as diabetes mellitus. * females who had history of fracture or trauma to the hand .
linkage and identification of (a) candidate gene(s) for tooth disorders

Conditions: Anodontia

Summary: the congenital absence of teeth, commonly referred to as hypodontia or tooth agenesis, is a common developmental anomaly of human dentition that affects approximately 20% of the population. although new genetic and molecular approaches in humans and mice have increased our understanding of the molecules that control tooth patterning (number, position, shape and size), the precise nature of the genes involved in hypodontia in humans is poorly understood. hence, understanding the molecular basis for missing teeth is an issue of paramount importance that is both timely and significant to the practice of dentistry. so far, only two genes have been associated with non-syndromic familial tooth agenesis: msx1 and pax9. substitution mutations in the homeodomain region of msx1 were linked to premolar agenesis while an insertion mutation in the paired box domain of pax9 was shown to be responsible for molar oligodontia. the long-term goals of this research are to elucidate the molecular pathology of human tooth agenesis, in particular, to evaluate whether genes other than msx1 and pax9 (locus heterogeneity) are involved. alternatively, as in the case of msx1, it will be interesting to know whether allelic variations, different mutations in these genes, are associated with tooth agenesis. we propose to study a potentially large kindred that report the developmental absence of several posterior teeth. the fundamental hypothesis to be tested states that the gene responsible for the congenital absence of molar teeth in this kindred is a critical element in the genesis of molars. the specific goals are to perform linkage analysis followed by direct sequencing of pcr products to identify the gene and to characterize the nature of the underlying defect. identifying the underlying gene defect in this family affected by tooth agenesis will add new knowledge to our understanding of the pathogenesis of this defect and will provide the basis for future studies.


Eligibility criteria:
* patients affected with non-syndromic tooth agenesis and non-affected family members

Keywords: human tooth agenesis
task-oriented training on hand function in taxanes-induced peripheral neuropathy

Conditions: Peripheral Neuropathy; Chemotherapy Effect; Hand Function

Summary: chemotherapy based on taxanes is commonly used to treat breast cancer. however, chemotherapy-induced peripheral neuropathy (cipn), a side effect of taxanes, impairs a patient's grip strength, hand dexterity, and upper extremity function which affects quality of life (qol).

task-oriented training, a type of exercise where exercises are organized into tasks, concentrates on enhancing particular functional abilities through useful, goal-directed activities. so, the purpose of the study to explore the effectiveness of task-oriented training (tot) on grip strength, hand dexterity and upper extremity function in patients with taxanes-induced peripheral neuropathy.

Eligibility criteria:
inclusion criteria: * patients were females only. * their ages range from 35 to 65. * all patients suffered from cipn after using taxanes (anti-cancer agent causing neurotoxic effect). * diagnosis of cipn was determined based on symptom history or the presence of stocking glove pattern "distal dysesthesias, pain and numbness" beginning after taxanes intake. * all patients enrolled to the study had their informed consent. * patients suffer from affected brachial plexus. exclusion criteria: * patients had pain or numbness in the upper extremity due to other reasons like trauma (fracture), cns diseases (cerebral infarction), other diseases with neurological symptoms like (diabetes, rheumatoid arthritis or cervical myelopathy). * patients had bone, brain or spinal cord metastases. * patients who had history of psychiatric disorders like: depression and schizophrenia or cognitive decline that may hinder them from active participation in the study. * patients exhibited only acute neuropathy like in patients using oxaliplatin. exclusion criteria: * patients had pain or numbness in the upper extremity due to other reasons like trauma (fracture), cns diseases (cerebral infarction), other diseases with neurological symptoms like (diabetes, rheumatoid arthritis or cervical myelopathy). * patients had bone, brain or spinal cord metastases. * patients who had history of psychiatric disorders like: depression and schizophrenia or cognitive decline that may hinder them from active participation in the study. * patients exhibited only acute neuropathy like in patients using oxaliplatin

Keywords: breast cancer hand dexterity hand grip strength task-oriented training taxanes-induced peripheral neuropathy
study of the efficacy and safety of the combination of two fda approved oral medications, nebivolol and valsartan for treatment of stage 1 or 2 hypertension

Conditions: Stage 1 Hypertension; Stage 2 Hypertension

Summary: to evaluate the efficacy and safety of fixed-dose combination of nebivolol and valsartan compared to monotherapy and placebo in patients with stage 1 and stage 2 hypertension.


Eligibility criteria:
inclusion criteria: * male or female outpatients of age 18 years or above * patients diagnosed with stage 1 or stage 2 essential hypertension * normal physical examination findings, electrocardiogram (ecg) results and chest x-ray; or abnormal findings judged by the investigator to be not clinically significant exclusion criteria: * secondary hypertension or severe hypertension * clinically significant cardiovascular disease or heart failure * clinical significant respiratory disease that would prohibit the use of a beta blocker * a medical contraindication to discontinuing a current antihypertensive therapy * history of type 1 diabetes mellitus * history of severe mental illness except mild depression

Keywords: stage 1 stage 2 hypertension
prognostic determinants of survival and quality of life in prevalent end-stage kidney disease patients

Conditions: Dialysis; Quality of Life; Nutrition

Summary: patients with end-stage kidney disease are treated with dialysis to increase their life expectancy as well as their quality of life (qol). scientific researchers are currently still looking for markers to evaluate dialysis in an objective way. it has been proven before that the currently clinically used parameters (like the dialysis adequacy parameter kt/v) are not appropriate enough to estimate dialysis dose. the current project aims at identifying potential (predicting) biomarkers based on functional capacity, nutritional status and/or qol.

this multisite study is an observational study during which prevalent dialysis patients are followed during maximum 3 years, and they undergo different tests. once a year (max 3 times), blood is sampled, stool is collected, and finger nails are taken all before a midweek session. demographic data are registered and davies-stokes scores are calculated. blood is analysed for different solutes: e.g. total and free fractions of protein-bound toxins, sedimentation, erythrocytes, hematocrit, leukocytes, thrombocytes, ferritin, vitb12, fasting glucose, c-reactive protein, urea, creatinine, albumin, total protein, cholesterol, triglycerides, bilirubin,... at the same occasion, patients are questioned about different items (qol, nutrition) by a (study) nurse or coordinator, using different questionnaires: euroqol 5 dimension scale (eq-5d), patient-reported outcomes measurement information system (promis-29), and mini nutritional assessment (mna). a subgroup of patients were asked to perform some functional tests: tinetti-test, sit to stand (5 times), frailty and injuries: cooperative studies on intervention techniques (ficsit) test, 2 or 6 minutes walking test, handgrip strength and quadriceps power measurement, back scratch test, compensatory stepping correction-backward test and skin fold measurement. all tests are non-invasive and are validated for routine measurements in the elderly. in order to quantify sleep, patients were asked to wear a motionwatch (actigraphy) to register their arm movements during 2 or 3 nights as well as to fill out 2 questionnaires related to sleep: pittsburgh sleep quality index (psqi) and insomnia severity index (isi). to compare sleep in dialysis patients with healthy persons, age and gender matched healthy volunteers were also included in the study and were asked to sleep 2 or 3 nights with the motionwatch and to complete the isi and psqi. patients who were transplanted got an extra blood sampling just before transplantation as well as 4 months after transplantation.

Eligibility criteria:
inclusion criteria: - end-stage kidney disease patients treated with dialysis (peritoneal dialysis or hemodialysis) exclusion criteria: * active inflammation * malignancy * cognitive disorder * not understanding the dutch language
preoperative radiation therapy for high risk prostate cancer

Conditions: Prostate Cancer

Summary: this is a phase i dose-escalation study of moderate dose radiation therapy prior to radical prostatectomy for patients with high-risk localized disease. its hypothesis is that such treatment will be well tolerated with similar side effect profile as surgery alone. patients in groups 1 and 2 will receive 39.6 gy and 45 gy (at 1.8 gy/fx), respectively, to the whole pelvis. patients in groups 3 and 4 will receive 45 gy to the whole pelvis, followed by a boost to the prostate and periprostatic tissue, for total doses of 50.4 and 54 gy, respectively. the patient will then undergo radical prostatectomy between 4-8 weeks after completion of radiation.


Eligibility criteria:
inclusion criteria: subjects must have * biopsy-confirmed "high-risk" prostate cancer, defined as a. psa \> 20, b. gleason score (gs) \>/= 8, and/or c. clinical stage t3 disease per ajcc staging manual, 6th edition; or d. at least two out of three of the following: psa 10-19.9, gs = 7, or clinical stage = t2b / t2c. * a negative bone scan, * be medically fit to undergo surgery as determined by treating urologist, * age \> 18, * kps must be \>/= 80, * no prior pelvic radiation therapy, chemotherapy, or androgen deprivation, * no prior invasive malignancy, except non- melanomatous skin cancer unless disease free for a minimum of 5 years. carcinoma in-situ of the bladder or head and neck region is permissible. * subjects must freely sign informed consent to enroll in the study. exclusion criteria: * prior pelvic radiation therapy, chemotherapy, or androgen deprivation, * prior invasive malignancy, except non- melanomatous skin cancer, carcinoma in-situ of the bladder or head and neck region, unless disease free for a minimum of 5 years. * metastatic disease as demonstrated by bone scan, ct scan or mri of the pelvis, or chest x-ray. * pathologically documented positive pelvic lymph nodes. if pre-operative ct scan or mri (ordered at the discretion of the treating physicians) demonstrates lymph nodes which are suspicious for involvement, then biopsy must be undertaken and nodes proven negative before patient can enroll on this trial. * declared high-risk for anesthesia by attending anesthesiologist, cardiologist, or other physician. * history of prior pelvic radiation therapy. * history of androgen deprivation therapy or chemotherapy.

Keywords: prostatectomy radiation neoadjuvant
family-centered diabetes project - sharing wisdom

Conditions: Prediabetes; Metabolic Syndrome; Overweight; Obesity

Summary: this is a randomized trial of an educational intervention to reduce the risk of diabetes among urban american indian women

two hundred american indian women aged 18 to 40 years were recruited from a large southwest city to participate in a type 2 diabetes prevention intervention. half of the women were randomized to participated in the educational intervention and half were assigned to a delayed intervention. measures were obtained at baseline, 6-months,12-months and 18-months.

Eligibility criteria:
inclusion criteria: * american indian women * aged 18-40 years * living in albuquerque area * not having diabetes exclusion criteria: * pregnancy * planning to become pregnant within 2 years * diagnosed with diabetes fasting blood glucose \> 126 planning to move out of town in next 2 years

Keywords: diabetes prevention american indian
calibration of a wrist cuff blood pressure device, according to the aami/esh/iso universal standard

Conditions: Hypertension

Summary: the objective of this study is to calibrate the blood pressure measurements of the pulsewave health monitor (pad-2a) device to be within 5±8 mmhg of the average of the dual-observer measurements via an aneroid sphygmomanometer (reference device), as per the methodology described in the iso 81060-2: amd_2020 protocol.

the plan for this study is to calibrate the blood pressure measurements of the pad-2a device with the dual-observer blood pressure measurements via an aneroid sphygmomanometer (reference device), as per the iso 81060-2: amd_2020 protocol. the data will be collected and analyzed in order to calibrate the pad-2a device blood pressure measurements to be within 5±8 mmhg of the average of the dual-observer auscultatory blood pressure measurements by adjusting the device algorithm.

Eligibility criteria:
inclusion criteria: * adults ≥ 19 years of age (minimum 30% male/female) * wrist circumference between 13.5 cm. - 23 cm. (5.3 in. - 9.1 in.): specifically for this test device, the wrist size of the consented participants will be distributed accordingly for a gaussian distribution: lowest octile: ≥ 13.5cm to \< 14.7cm lower quarter: ≥ 13.5cm to \< 15.9cm lower-middle quarter: ≥ 15.9cm to \< 18.3cm upper-middle quarter: ≥ 18.3cm to \< 20.7cm upper quarter: ≥ 20.7cm to ≤ 23.0cm highest octile: ≥ 21.9cm to ≤ 23.0cm ● willing to volunteer to participate and to sign the study specific informed consent form exclusion criteria: * wrist circumference less than 13.5 cm. (5.3 in.) or greater than 23 cm. (9.1 in) * hand or body tremors * irregular heart rhythm (bigeminy, trigeminy, isolated ventricular premature beat (vpb), atrial fibrillation) * korotkoff sound k5 not audible * pregnant * a musculoskeletal disorder that prevents a non-invasive device to be inflated/deflated on the arm * unwilling to volunteer to participate and to sign the study specific informed consent form

Keywords: hypertension blood pressure telemedicine telemonitoring vital sign monitoring
study of demarcation line depth in transepithelial versus epithelium-off accelerated cross-linking (axl) in keratocouns

Conditions: Progressive Keratoconus

Summary: to assess depth of demarcation line in transepithelial versus epithelium-off accelerated cross-linking in keratoconus patients

anterior segment optical coherence tomography "oct" will be performed to evaluate the corneal stroma for the presence of demarcation line 1 month postoperatively by an independent observer unware of purpose of study

Eligibility criteria:
inclusion criteria: * progressive keratoconus stage 1-2 exclusion criteria: * any concomitant ocular disease
aortic stenosis pre-transcatheter aortic valve replacement (tavr) procedure ct scan

Conditions: Aortic Valve Stenosis

Summary: the purpose of this study is to evaluate contrast media volume, safety and 30-day outcome of patients after a computed tomography (ct) scan. the results of this study will help to determine the minimum volume of contrast material that can be used to ensure patient safety while not compromising diagnostic image quality in high-risk patients.

the scholarly rationale for the study is to determine the feasibility of restricting the contrast media volume to 60ml of 270mg iodine (mgi)/ml iodixanol or less to accomplish sufficient intravascular attenuation for comprehensive ct assessment prior to tavr. the study will also evaluate the effects of contrast media administration on our subjects' kidney function by performing serum creatinine measurements at baseline, as well as at three days and thirty days after contrast media administration.

Eligibility criteria:
inclusion criteria: 1. subject must be 18-90 years of age. 2. subject must have been referred for a clinically indicated ct prior to tavr. 3. subject must provide written informed consent prior to any study-related procedures being performed. 4. subject must be willing to comply with all clinical study procedures. exclusion criteria: 1. subject is a pregnant or nursing female. exclude the possibility of pregnancy: * by testing (serum or urine βhcg) within 24 hours before contrast agent administration, or * by surgical sterilization, or * post menopausal, with minimum one (1) year history without menses. 2. subject has an acute psychiatric disorder or is cognitively impaired. 3. subject is using or is dependent on substances of abuse. 4. subject is unwilling to comply with the requirements of the protocol. 5. subject has previously entered this study. 6. subject has an allergy against iodinated contrast agents. 7. subject is in acute unstable condition.

Keywords: comorbidity