Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of bg00012 in ms

Conditions: Multiple Sclerosis

Summary: determine the efficacy, safety, and tolerability of bg00012 in ms patients.

the study will be divided into two parts: part 1 will be a 24-week, blinded, placebo-controlled treatment phase followed by part 2, a 24-week blinded, safety extension phase in which all subjects will receive bg00012.

Eligibility criteria:
inclusion criteria: 1. must be 18 to 55 years old, inclusive, at the time of informed consent. 2. must have a confirmed diagnosis of relapsing-remitting ms according to mcdonald criteria #1-4 (mcdonald et al, 2001; appendix 2). 3. must have a baseline edss between 0.0 and 5.0, inclusive. 4. must have experienced at least one relapse within the 12 months prior to randomization, with a prior cranial mri demonstrating lesion(s) consistent with ms or show evidence of gd-enhancing lesions of the brain on an mri performed within the 6 weeks. 5. male and female subjects must be willing to take appropriate measures to prevent pregnancy. exclusion criteria: 1. primary progressive, secondary progressive, or progressive relapsing ms (as defined by lublin and reingold, 1996 \[appendix 3\]). 2. history of malignancy. 3. history of severe allergic or anaphylactic reactions or known drug hypersensitivity. 4. history of abnormal laboratory results indicative of any significant cardiac, endocrinologic, hematologic, hepatic, immunologic, metabolic, urologic, pulmonary, gastrointestinal, dermatologic, psychiatric, renal, neurologic (other than ms), and/or other major disease. 5. history of human immunodeficiency virus (hiv). 6. history of drug or alcohol abuse (as defined by the investigator) within the 2 years prior to randomization. 7. an ms relapse that has occurred within the 50 days prior to randomization and/or the subject has not stabilized from a previous relapse prior to randomization. 8. body weight \>100 kg. 9. positive for hepatitis c antibody and/or positive for hepatitis b surface antigen (hbsag) at screening. 10. any of the following abnormal blood tests at screening. 11. any previous treatment with fumaderm®, fag-201, or bg00012. 12. a medication history that precludes entry into the study. 13. female subjects who are currently pregnant or breast-feeding.

Keywords: multiple sclerosis mri
therapeutic effects of insoles on patients with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: using double blind, randomized controlled design to study the immediate, short-term and intermediate-term therapeutic effects of ready-made full-length lateral wedged shoe insoles and customized full-length lateral wedged shoe insoles to patients with knee osteoarthritis, under the basis of international classification functioning, disability and health.

a total of 90 patients will be collected. the participants will be randomized into two groups, including ready-made full-length lateral wedged shoe insoles group and customized full-length lateral wedged shoe insoles group. the psychological function (hospital anxiety and depression scale, graded chronic pain scale, multidimensional fatigue inventory, fear-avoidance belief questionnaire), physical activity (champs physical activity questionnaire), functional performance (western ontario and mcmaster universities osteoarthritis index、knee injury and osteoarthritis outcome score) and quality of life (world health organization-quality of life-brief vision、osteoarthritis quality of life、osteoarthritis- knee and hip quality of life) will be evaluated. physical functional ability (10 meter normal and fast walk, up and down stairs, and 5 repeated chair-rising time), pain (visual analog scale, pain pressure threshold ) and balance performance (static postural stability and dynamic stability by biodex stability system, including postural stability, dynamic limits of stability and fall risk) will be evaluated before and immediately after the ready-made full-length shoe insoles and customized full-length shoe insoles are prescribed. all the evaluations, including physical functional ability, pain, balance, psychological, physical activity, functional performance, and quality of life, will be re-evaluated at one month after and three months after modified shoe insoles wearing. subjects and evaluator were both blinded to the group's classification during the whole course of study.

Eligibility criteria:
inclusion criteria: * fulfill the combined clinical and radiographic criteria for knee osteoarthritis, as established by the american college of rheumatology * with kellgren-lawrence scores of 2 or higher in the isolated medial compartment exclusion criteria: * with a history of previous knee surgery with an implant * reduced lateral compartment and/or combined medial and lateral compartments in knee joints were excluded * pregnant or planning to become pregnant * self-reported history of vertigo, malignancy, stroke, or other conditions that may impair vestibular function

Keywords: knee osteoarthritis therapeutic effect insole
genetically targeted therapy for the prevention of symptomatic atrial fibrillation in patients with heart failure

Conditions: Current or Recent History of Atrial Fibrillation

Summary: this study is being done to compare the effects of bucindolol hydrochloride (bucindolol) to metoprolol succinate (toprol-xl) on the recurrence of symptomatic atrial fibrillation/atrial flutter in patients with heart failure who have a specific genotype for the beta-1 adrenergic receptor.

the goal of the genetic-af trial is to demonstrate the superiority of pharmacogenetically targeted bucindolol compared to metoprolol for the prevention of symptomatic atrial fibrillation or atrial flutter in a genotype-defined population with heart failure and/or reduced left ventricular ejection fraction at high risk of atrial fibrillation/atrial flutter recurrence.

Eligibility criteria:
key inclusion criteria: * must weigh at least 40 kg * possess the β1389 arg/arg genotype * left ventricular ejection fraction (lvef) \< 0.50 assessed within 12 months prior to screening * at least one episode of symptomatic paroxysmal or persistent af within 180 days of screening * clinically appropriate for electrical cardioversion (ecv) if af/afl is present after study drug initiation * receiving appropriate anticoagulation therapy prior to randomization key exclusion criteria: * nyha class iv symptoms at the time of randomization * significant fluid overload at randomization * permanent af at screening * more than two previous ecv within 6 months of randomization or if the most recent ecv failed to produce sr * presence of an lvad, or likely to requirement lvad placement within 6 months of randomization * history of a successful atrioventricular (av) node ablation * history of an af/afl ablation within 30 days of randomization * evidence of an appropriate firing of an implanted cardioverter-defibrillator (icd) device for ventricular tachycardia (vt) or ventricular fibrillation (vf) within 90 days of randomization

Keywords: atrial fibrillation atrial flutter heart failure reduced left ventricle ejection fraction electrical cardioversion genetic-af medtronic bucindolol pharmacogenetic arca toprol toprol-xl metoprolol metoprolol succinate
effects of a recovery supplement on body composition, performance, muscular properties, and wellbeing

Conditions: Protein Deficiency; Training Group, Sensitivity; Fatigue; Muscular Atrophy; Psychological

Summary: the investigation will be conducted as a double blinded, randomized, parallel between treatment conditions comparison design with two different groups ingesting a different supplement each one.

following inclusion, familiarization and baseline assessments, the participants will be randomly allocated to receive either a multi-ingredient, post-workout supplement (rec) or maltodextrin (cho). thereafter, the participants will follow a 6-weeks resistance training mesocycle, involving three resistance training sessions (monday, wednesday and friday) per week (18 sessions in total). before and after the 6 weeks of intervention, the following assessments will be performed: (i) body composition (fat mass and fat-free mass) via air displacement plethysmography (bodpod); (ii) muscle contractile properties on vastus medialis and anterior deltoids (via tensiomyography; (iii) muscle structure of the vastus lateralis of the quadriceps and the elbow flexors of dominant extremities via ultrasound; (iv) maximal isometric strength (isometric mid-thigh pull); (v) upper and lower body muscular power (medicine ball throw and vertical jump), (vi) upper and lower muscular endurance (30- seconds sit-to-stand and 30-seconds 16rm bench press), (vii) immune system (via hemocue wbc diff system). the supplements will be ingested immediately (within 15 min) after each training session. energy feeling questionnaire will be filled immediately before warming up. in addition, rate of perceived exertion to training will be assessed 15 min after the completion of all workouts.

Eligibility criteria:
inclusion criteria: * healthy (no injuries, illnesses or medication intake). * between 45 and 65 years old. * active and familiarised with resistance training. exclusion criteria: * unhealthy (illnesses or medication intake) or injured. * untrained. * young (\ 65 y.o.).

Keywords: fatigue supplement protein creatine resistance training recovery strength rate of perceived exertion muscle
protect and improve cluster of differentiation 4 (cd4) cells and b cells lymphocytes

Conditions: HIV-1-infection; AIDS

Summary: this is a plant-based medication used to increase the amount, protect, and reduce hiv's impact on t and b lymphocytes.

dioscorea cirrhosa, impatiens balsamina, eclipta prostrata, phyllanthus urinaria, adenosma glutinosum, and ascorbic acid are used to elevate t and b lymphocytes level, protect their cells membrane, decrease the damage of hiv on cd4+ t. in detail, diosgenin presented in dioscorea cirrhosa is a precursor of cortisol. dioscorea cirrhosa when combined with ascorbic acid helps to balance cortisol levels which reduces cell inflammation. flavonoids of dioscorea cirrhosa also help to increase cd4+ t levels. impatiens balsamina can be used as an antitoxin alternative against bacteria or viruses. flavonoids in impatiens balsamina, such as kaempferol, quercetin, rutin, astragalin, have the ability to reduce the virus's impact on t lymphocyte, protect their cell membrane, produce antihistamine, protect the cell from inflammation. targeted flavonoids in eclipta prostrata, phyllanthus urinaria, adenosma glutinosum are used to cell repair, protect and increase cd4+ t production. ascorbic acid in combination with herbal extracts creates a favorable environment for body metabolism, improves the medication's effectiveness.

Eligibility criteria:
inclusion criteria: * participants have a decline in cd4 + t-lymphocytes is the hallmark of hiv-1 infection. characterized by rapid loss of resistance: aids * dermatitis, mouth ulcers, skin rash, itching, weight loss * hcv (+), hbv (+), tuberculosis (+) exclusion criteria: * cancer under all form
identifying biomarkers for early detection of cancer in patients with cervical dysplasia or carcinoma in situ of the cervix

Conditions: Cervical Cancer; Precancerous Condition

Summary: rationale: studying the genes expressed in samples of tissue from patients with abnormal cells may help doctors identify biomarkers related to cancer. purpose: this clinical trial is identifying biomarkers for early detection of cancer in women with cervical dysplasia or carcinoma in situ of the cervix.

objectives: primary * to identify and catalogue genetic alterations and protein changes associated with developmental stages of cervical cancer. * to identify a ranked list of candidate genes that drive the transformation of premalignant lesions to tumors for further study and validation as molecular targets for novel early detection and treatment design. secondary * to complete genome scans at high density and analysis of gene and protein expression to identify recurrent genetic and protein changes in cancer. * to confirm changes clustered to specific chromosomal regions which harbor tumor suppressors or oncogenes. outline: patients undergo biopsy of cervical tissue followed by loop electrocautery excision procedure (leep) (removing all of the tissue surrounding and under the area biopsied). rna, dna, and protein is extracted from the cells to provide material for the construction of libraries for serial analysis of gene expression (sage analysis); for hybridization against bacterial artificial chromosome comparative genome hybridization arrays (bac cgh arrays); and for analysis using protein chip arrays and proteomics. resulting data from coded samples provide gene expression and protein profiles. the coded molecular datasets are linked, analyzed, and compared using a variety of statistical software to identify putative genes, gene alterations, and proteins of interest. some samples may be banked for future studies.

Eligibility criteria:
disease characteristics: * histologically or cytologically confirmed premalignant lesion, dysplasia, or carcinoma in situ of the cervix * clinically documented disease * attending vancouver general hospital and referred to colposcopy for loop electrocautery excision procedure (leep) patient characteristics: * not pregnant * no lack of informed consent due to language difficulty, physical and mental condition prior concurrent therapy: * no prior operation for removal of the cervix * concurrent therapy allowed

Keywords: stage 0 cervical cancer cervical intraepithelial neoplasia grade 1 cervical intraepithelial neoplasia grade 2 cervical intraepithelial neoplasia grade 3
causal relationship between dry eye and accommodative spasm

Conditions: Dry Eye

Summary: to investigate the causal relationship of sicca dry eye patients with presbyopic refractive error and accommodative spasm.

dry eye is a disease of the ocular surface. severe dry eye produce symptom of discomfort in and around the eye that drastically affect life quality of the patient. osdi index is retrieve from a questionnaire specific for these dry eye symptoms, it is an internationally accepted level to reveal the severity of dry eye disease. one part of the symptom is pain and soreness around the eye. hyperalgesia is an increase response to a stressful/ noxious stimulus whereas allodynia is a painful response to a normally innocuous stimulus. our hypothesis state that sicca dry eye upregulated inflammatory cytokine in the eye has pre-sensitized the nociceptor nerve fiber in the cornea and orbit, therefore the normally innocuous effort of accommodation and ciliary muscle contraction produce intolerable retro-orbital eye pain, which drives the patient to seek medical attention, on presentations these patient show an elevated osdi and pain index (pi).

Eligibility criteria:
inclusion criteria: - dry eye exclusion criteria: * under 20 year old
gastric assessment ambulatory surgery

Conditions: Full Stomach

Summary: the surgical procedures in outpatient surgery are in perpetual increase. however, the peri operative stress can reduce the gastric emptying. a patient's compliance for following the fasting rules cannot be controlled at home. ambulatory surgery is currently proposed to fragile patients with many comorbidities known to slow gastric emptying. in day case surgery the airway management are often managed with supraglottic device ( laryngeal mask). this device does not protect the respiratory tract and may expose the patient to a risk of inhalation of gastric content (if not empty). this study aim to mesure the prevalence of full stomachs in outpatient surgery and to observe any changes in anesthetic management secondary to the ultrasound assessment of gastric content. it will confront theoretical full stomach risk factors with ultrasound findings. the practical and clinical relevance of such a technique in the context of outpatient surgery will be assessed in this study. the ultimate goal is to improve the safety of the patient's anesthetic management by controlling the risk of pulmonary aspiration.

patients will be included during the pre-anesthetic evaluation. the theoretical full stomach risk factors and the anesthetic management will be recorded in the computerized pre-anesthetic evaluation. a qualitative and quantitative ultrasound evaluation will be performed when the patient arrives in the pre-anesthesia room. the examination will be performed in the right lateral decubitus with a low frequency convex ultrasound probe. the main objective is to measure the prevalence of patients with a "full stomach" based on ultrasound criteria. the primary endpoint is the presence of solid or fluid greater than 1.5 ml / kg of the predicted ideal body weight during ultrasonographic evaluation of gastric contents. in this situation, the patient will be considered at high risk of inhalation (considered full stomach). this study will observe and record any anesthetic changes (ie : airway management) secondary to this ultrasouund assessment of gastric contents.

Eligibility criteria:
inclusion criteria: affiliation to social security. be over 18 years old. have signed informed consent for this study. score from the american society of anesthesiology (asa) 1, 2, or 3. being admitted for ambulatory day care surgery. exclusion criteria: patients who are protected or unable to give consent patients with cognitive dysfunction, or unable to give their consent according pregnant or lactating women. vulnerable people. patients with a history of esophageal or gastric surgery patients suffering from hiatal hernia with esophageal reflux

Keywords: pulmonary aspiration, full stomach, gastric content inhalation, mendelson syndrom
safety and efficacy of pregabalin in patients with diabetic peripheral neuropathy.

Conditions: Diabetic Neuropathy, Painful

Summary: to evaluate long-term efficacy and safety of pregabalin in patients with diabetic peripheral neuropathy.


Eligibility criteria:
inclusion criteria: * must have met the inclusion criteria for preceding double-blind study * must have received pregabalin or amitriptyline or placebo under double-blind conditions under double-blind conditions at least during first 3 weeks if double-blind treatment phase of preceding study. exclusion criteria: * patients cannot be included if they experienced a serious adverse event while participating in preceding double-blind study, which was determined to be related to the study medication.
deep learning to summarize findings in dental panoramic radiographs

Conditions: Radiography; Digital; Dental Diseases; Dentist-Patient Relations

Summary: in this work, the investigators study the application of artificial intelligence systems on dental panoramic images for dental findings. an artificial intelligence system will be learned on an publicly available panoramic image dataset, and test against the investigators' local patient cohort as external test data. the investigators hypothesize the performance would be similar, if not identical to on the public data, and that the investigators' ai system is generalizable.


Eligibility criteria:
exclusion criteria: * patients under 20 or with primary teeth * patients with non-removable metal accessory above neck, such as tongue ring, nose ring etc. * patients with mandible or maxilla deformation
vitamin k2 supplementation to activate matrix gla protein (mgp) as endogenous inhibitor of vascular calcification in hemodialysis patients

Conditions: CKD 5D, Hemodialysis

Summary: vascular calcification (vc) is a predictor of cardiovascular morbidity and mortality. hemodialysis (hd) patients suffer from severe vascular calcifications. matrix gla protein (mgp) is a central calcification inhibitor of the arterial wall and its activity depends on vitamin k-dependent γ-glutamate carboxylation. noncarboxylated mgp, formed as a result of vitamin k deficiency, is associated with cardiovascular disease. recent studies pointed towards poor vitamin k status in hd patients. we therefore aim to investigate whether daily vitamin k2 (mk-7) supplementation improves the bioactivity of vitamin k-dependent proteins in hd patients as assessed by circulating dephospho-noncarboxylated mgp (dp-ucmgp), noncarboxylated osteocalcin (ucoc) and noncarboxylated prothrombin (ucfii; pivka-ii).


Eligibility criteria:
inclusion criteria: * \> 18 years of age * minimum of 3 months of hemodialysis * written consent exclusion criteria: * chronic or acute bowel disease * soy bean allergy * active vitamin k supplementation * oral anticoagulation with vitamin k antagonists (coumarins) * systemic therapy using steroids * positive history for thrombosis or embolism * pregnancy

Keywords: vitamin k mk-7 hemodialysis vascular calcification matrix gla protein osteocalcin
validation of triggered emg values for pedicle screws using a powered screwdriver

Conditions: Scoliosis

Summary: previous studies have shown how triggered electromyogram (emg) pedicle screw stimulation can be used to effectively test correct pedicle screw placement in the lumbar and thoracic vertebrae. most papers agree that if more than 6ma of current are needed to elicit a response the screw is correctly placed in the bone. if there is a response with less than 6ma there is a strong likelihood of a breach of the pedicle wall or invasion of the spinal canal. typically this triggered emg stimulation is done after all the screws have been placed with a ball-tipped probe and is paired with intraoperative fluoroscopy to ensure correct placement of the screws. another method of testing the current for each screw is with a powered screwdriver, which can stimulate and give a reading as the surgeon places each screw. both of these methods are currently used by surgeons, however the powered screwdriver has been found to be a faster method. the investigator's aim with this study is to compare these two methods of testing triggered emg values. the investigators plan on doing this by testing each screw with both the ball-tipped probe and the powered screwdriver, in order to see if there are any statistically significant differences between the readings.

the purpose of the study is to compare two methods of testing triggered emg values. all study measurements will be recorded during the surgical procedure. no follow up is required with the patient involved and no personal health information will be recorded from the patients.

Eligibility criteria:
inclusion criteria: * between the ages of 8-21 years * diagnosis of adolescent idiopathic scoliosis (ais) * scheduled to receive a spinal fusion exclusion criteria: * diagnosis of any other type of scoliosis (infantile, juvenile, congenital, neuromuscular, etc)

Keywords: scoliosis emg pedicle screw neuromonitoring