Kornimate/medical-research-clean huggingface dataset:
assessment of gait after dysport treatment

Conditions: Equinovarus; Acquired

Summary: this pilot study will aim to understand the potential benefit of the assessment of walking using video slow motion for muscle selection and the development of an image catalogue guide of the potential results of injection of abobotulinumtoxina by comparing foot postures before and after injection. the objective is to evaluate the use of video assessment to improve muscle selection for the injection of botulinum toxin a to improve walking outcomes. primary outcomes include: self-selected velocity (ssv), maximal velocity (mv) and symmetry of walking. secondary outcomes include: passive range of motion (prom), modified ashworth scale (mas) and the tardieu scale (ts). fifteen persons post stroke or tbi over age 18 with equinovarus foot deformity who are able to ambulate will be included in the study. dysport 1000 to 1500 units will be used to be distributed on the basis of clinical indication to ankle plantar flexors (gastrocnemius and soleus), tibialis posterior and long toe flexors. the duration of subjects' participation is 4-6 weeks.

this is a prospective, single arm, non-randomized clinical study with pre-post assessment to include post-stroke and traumatic brain injury (tbi) outpatients with spastic ankle / foot muscles amenable to botulinum toxin injection. subjects must be able to walk without braces. abobotulinumtoxina injection in a dose range of 500 to 1500 units one time to be distributed on the basis of clinical indication to ankle plantar flexors (gastrocnemius and soleus), knee extensors, knee flexors, tibialis posterior and long toe flexors.

Eligibility criteria:
inclusion criteria: * provide signed and dated informed consent form * willing to comply with all study procedures and be available for the duration of the study * male or female, aged ≥ 18 * equinovarus foot deformity appropriate for botulinum toxin treatment (naïve or non-naïve) * modified ashworth scale between 1 to 3 * women of reproductive potential must use effective contraception for the duration of the study exclusion criteria: * inability to walk without leg brace * previous surgical intervention to affected/ankle/foot * uncontrolled seizures * pregnancy or lactation * known allergic reactions to dysport * treatment with another investigational drug or other intervention in the past 4 months * modified ashworth scale 4 * anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study * lower motor neuron disorder * \< four months post botulinum toxin or serial casting
rosmarinus officinalis versus 2.5%sodium hypochlorite as root canal irrigants

Conditions: Necrotic Pulp

Summary: to measure the effect of rosmarinus officinalis versus 2.5%sodium hypochlorite as root canal irrigants on the intensity of post-operative pain and bacterial reduction in asymptomatic necrotic mandibular premolars.


Eligibility criteria:
inclusion criteria: 1. systematically healthy patient (asa i and ii). 2. age between 20 and 45 years with no sex predilection 3. mandibular permanent premolar teeth: * diagnosed clinically with pulp necrosis. * absence of spontaneous pain. * radiographic evidence of root and root canal. * slight widening in the periodontal membrane space or with periapical radiolucency. * no response to cold pulp tester (ethyl chloride spray) 4. patients who can understand and interpret numerical rating scale (nrs). 5. patients' acceptance to participate in the trial exclusion criteria: * 1- medically compromised patients having significant systemic disorders. (asa iii or iv). 2- history of intolerance to nsaids. 3- if analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception. 4- pregnant women: avoid radiation exposure, anesthesia, and medication. 5- teeth with: i. vital teeth. ii. double canal mandibular premolar teeth iii. association with swelling or fistulous tract. iv. acute peri-apical abscess and swelling: need special treatment steps which could involve additional visits with incision and drainage. also, it could influence initiation and progression of postoperative pain. v. mobility grade ii or iii. vi. pocket depth more than 5mm. vii. previous root canal therapy. viii. non-restorable teeth: hopeless tooth * immature teeth. * radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.
identification of biomarkers for prediction of response or resistance against target therapy in gastric cancer

Conditions: Esophageal Neoplasms; Stomach Neoplasms

Summary: the aim of this study is to identify biomarkers predicting response or resistance factors of a targeted therapy with trastuzumab in advanced gastric cancer.


Eligibility criteria:
inclusion criteria: * histologically proven adenocarcinoma of the stomach or gastroesophageal junction * stage iv * patient receives chemotherapy * signed informed consent * age \> 18 years exclusion criteria: * patient can not understand meaning and purpose of the study * patient already received a chemotherapy treatment for advanced disease.

Keywords: non-interventional advanced gastric cancer trastuzumab her2
iron deficiency in pediatric celiac disease: diet vs. iron supplementation trial

Conditions: Celiac Disease in Children; Iron Deficiency

Summary: this study aims to understand how to best manage iron deficiency in children newly diagnosed with celiac disease. many children with celiac disease have low iron levels, even if they do not have anemia. while some doctors recommend iron supplements, others believe that simply following a gluten-free diet may be enough to restore iron levels naturally. in this study, children with newly diagnosed celiac disease and low iron levels (but normal hemoglobin) will be randomly assigned to one of two groups: gluten-free diet only - no additional iron supplements gluten-free diet + iron supplementation researchers will compare iron store levels over one year to see if iron supplements provide any additional benefit beyond the gluten-free diet alone. the study will also track possible side effects of iron supplements, such as stomach discomfort. this study will help doctors determine the best approach to managing iron deficiency in children with celiac disease, ensuring they receive the safest and most effective treatment.

this is a prospective, randomized, controlled, open-label, non-inferiority trial designed to evaluate the necessity of iron supplementation in children newly diagnosed with celiac disease and iron deficiency without anemia. the study will compare two treatment strategies: gluten-free diet alone gluten-free diet + iron supplementation the primary objective is to determine whether a gluten-free diet alone is sufficient to restore ferritin levels or if iron supplementation provides a significant additional benefit. study design \& methods eligible participants will be randomly assigned to one of the two treatment groups. ferritin levels will be monitored at baseline, 4 months, and 12 months to assess improvements. the study will also evaluate patient adherence to a gluten-free diet and iron supplementation, quality of life, as well as the incidence of gastrointestinal side effects related to iron supplement use. this study is expected to provide evidence-based guidance for the management of iron deficiency in pediatric celiac disease, addressing a gap in current clinical recommendations.

Eligibility criteria:
inclusion criteria: * children aged 18 months to 18 years * newly diagnosed with celiac disease (based on espghan guidelines) * ferritin levels below 15 ng/dl * normal hemoglobin, mcv, and mch levels for age and sex exclusion criteria: * iga deficiency preventing ttg antibody monitoring * potential celiac disease (positive serology with normal intestinal histology) * underlying diseases that may cause anemia (e.g., inflammatory bowel disease, eosinophilic gastrointestinal disease, certain gastritis types) * diseases affecting iron absorption (e.g., cystic fibrosis) * congenital anemia (e.g., thalassemia, hereditary spherocytosis) * prior iron supplementation (\>14 days oral iron within 2 months or iv iron within 6 months before diagnosis)

Keywords: celiac disease pediatric celiac disease iron deficiency ferritin levels gluten-free diet iron supplementation
postoperative radiotherapy in breast cancer- concurrent or sequential with chemotherapy

Conditions: Invasive Breast Cancer; Stage III Breast Cancer; Stage IIB Breast Cancer

Summary: this clinical research aims to determine if concurrent chemotherapy and radiation therapy is more effective than sequential chemotherapy and radiation therapy for patients with stage iib-iii breast cancer. it seeks to answer the following key questions: 1. when compared to sequential treatment, does concurrent chemoradiotherapy increase disease-free survival? 2. what effects does concurrent treatment have on post-operative look, quality of life, and side effects including arm swelling (lymphoedema)? 3. what are each treatment approach's financial costs? researchers will compare the following to groups: arm a: participants in the sequential treatment group will first undergo chemotherapy and then radiation. and arm b: participants in the concurrent treatment group will undergo radiation therapy while undergoing chemotherapy. participants are going to: 1. get the usual chemotherapy (taxanes and/or anthracyclines). 2. receive radiation therapy for three to four weeks. 3. have follow-up visits every 6months for 5years to check for cancer recurrence, side effects, and quality of life.


Eligibility criteria:
inclusion criteria: 1. pathologically confirmed invasive breast cancer 2. stage iib-iii invasive breast cancer (ajcc 8th edition) 3. patients planned for adjuvant chemotherapy and adjuvant radiotherapy 4. patients fit to receive adjuvant chemotherapy and radiotherapy 5. age \> 18 years exclusion criteria: 1. hypersensitivity to taxanes 2. patients receiving entire chemotherapy prior to surgery (neoadjuvant setting) 3. unable or unwilling for regular follow up 4. bilateral tumour needed rt to both sides 5. patients planned for rt to oligometastatic sites 6. unfavourable anatomical factors potentially leading to higher radiotherapy dose to heart and/or lungs (exceeding the protocol specific mandatory dose constraints). 7. pregnant patient

Keywords: invasive breast cancer chemoradiation sequential concurrent adjuvant therapy
ketone esters for appetite, cognition, and cardiovascular function in individuals with obesity and insulin resistance

Conditions: Metabolic Syndrome

Summary: the goal of this single-blind randomized placebo-controlled trial is to test the effects of an oral ketone supplement on appetite, cognition, metabolism, and cardiovascular function in individuals with obesity and insulin resistance. the main question\[s\] it aims to answer are: * does taking the ketone supplement reduce appetite and improve cognition? * how does the ketone supplement alter metabolism and cardiovascular function? participants will be asked to consume a randomly assigned ketone ester supplement or a placebo and testing will be done to see how the supplement affects the following compared to a placebo: * appetite, * cognition, * metabolism * cardiovascular function researchers will compare individuals with obesity and insulin resistance to individuals with normal weight and no insulin resistance to see if the ketone supplement affects groups differently.


Eligibility criteria:
inclusion criteria: * adults between the ages of 18-50 years of age. * presence of metabolic sydnrome control participant eligibility: * a waist circumference of \< 102 cm for males and \< 88 cm for females, and * no indication of metabolic syndrome exclusion criteria: * pregnant * breastfeeding or lactating * missing any limbs or part of a limb * having a substantial amount of metal implants (metal plates or complete joint replacements) * having a pacemaker or any other electrical implant * type i diabetes * gestational diabetes * taking insulin * any history of severe traumatic brain injury or mild traumatic brain injury within the last two years * kidney disease * liver disease * thyroid disease * any diagnosed neurological or neurodegenerative diseases * any surgeries that would impact swallowing and/or digestion * being on a ketogenic diet or having been on a ketogenic diet in the last 6 months * having received ionizing radiation from a medical procedure within the last 30 days * being on a medically prescribed diet
a study of atrasentan in men with metastatic, hormone-refractory prostate cancer

Conditions: Prostate Cancer

Summary: this study is being done to evaluate the safety and efficacy of atrasentan in men with metastatic hormone-refractory prostate cancer.


Eligibility criteria:
inclusion criteria: * diagnosis of prostate cancer. * rising psa while on hormonal therapy or following surgical castration. * documented evidence of metastatic disease. exclusion criteria: * have received cytotoxic chemotherapy. * have received opioid or narcotic medications (such as codeine or morphine) or radiation for pain caused by your prostate cancer in the last 6 months.

Keywords: hormone-refractory, prostate cancer
copd exacerbation blood and urine biomarkers study

Conditions: Chronic Obstructive Pulmonary Disease; Acute Exacerbation Copd; Alpha-1 Anti-trypsin Deficiency

Summary: this will be a prospective study examining serum levels of mmp-13 and alpha-1 antitrypsin as well as other biomarkers as well as urine biomarkers of smoking status and collagen degradation in the copd patient population. serum and urine biomarkers at baseline and after copd exacerbations will be assessed against change in lung function as measured by pulmonary function testing.

chronic obstructive pulmonary disease (copd), a term describing emphysema and chronic bronchitis, is the third leading cause of death in the united states, with approximately 24 million us adults estimated to have the disease and over 130,000 us adults dying each year due to copd. acute exacerbations of chronic obstructive pulmonary disease (aecopd), primarily the result of viral respiratory infections, result in accelerated decline in lung function and increased mortality. recent work in our laboratory demonstrates that matrix metalloproteinase-13 (mmp-13), which has both collagenolytic and elastolytic activity, is increased in the bronchoalveolar lavage fluid of patients with copd. it is well accepted that viral infections have significant consequences in smokers, particularly in patients with aatd related copd. copd exacerbations clinically manifest with increased dyspnea, cough and sputum production, and from a societal cost standpoint are associated with significant increases in health care utilization. recent data suggest that viral infections such as rsv increase mmp-13 secretion and expression within lung tissues. therefore, the studies presented here seek to understand the effect of mmp-13 on copd progression and the effect of disease exacerbations on mmp-13 and alpha-1 antitrypsin serum levels and later lung function decline. the investigators hypothesize that patients with copd, in particular patients who fall into the "frequent exacerbator" phenotype (two or more exacerbations within the last year), will have increased levels of mmp-13 as compared to the general non-copd patient population and that in the setting of a copd exacerbation, levels will be increased. the investigators will assess how exacerbation mmp-13 levels predict later lung function decline.

Eligibility criteria:
inclusion criteria: * diagnosed with copd (fev1 \<80% and fev1/fvc \< 70%) * ages 35-80yrs exclusion criteria: * history of asthma * bronchiectasis * carcinoma of the bronchus * recent copd exacerbation or pulmonary infection (less than 1 month) * other significant respiratory disease * pregnancy

Keywords: exacerbation cough sputum
observational study on the treatment of trigeminal neuralgia by radiosurgery

Conditions: Trigeminal Neuralgia

Summary: this study aims to evaluate the outcome of patient treated by radiosurgery on linac with high dose rate for classical trigeminal neuralgia

this retrospective and prospective case-series hospital-based study will be conducted in all patients with trigeminal neuralgia treated by radiosurgery on linac at the centre hospitalier princesse grace from april 2018 to january 2028. patients will be treated with frameless technic and receive 90 gy delivered with high dose rate on the intra cisternal portion of the trigeminal nerve.

Eligibility criteria:
inclusion criteria: * classical trigeminal neuralgia according the international classification of headache disorders * trigeminal neuralgia resistant to the maximum tolerated medical therapy, with pain intensity according to the barrow neurological institute (bni) score iv or v. * patients aged \> 18 exclusion criteria: * patients suffering from secondary trigeminal neuralgia (tumour in the cerebellopontine angle, arteriovenous malformation or multiple sclerosis) * previous history of radiosurgery procedure

Keywords: trigeminal neuralgia radiosurgery linac pain relief hypesthesia
enhanced safety aesthetic laser system

Conditions: Hirsutism; Hypertrichosis; Telangiectases; Rhytides

Summary: the purpose of this study is to determine whether a new laser system provides better safety and efficacy than existing lasers in popular cosmetic procedures such as hair removal, treatment of cosmetically disturbing vascular lesions and rhytides.

cosmetic lasers are a well-established, popular modality for removal of unwanted hair, treatment of all types of vascular lesions, including hemangiomas, port wine stains, and a variety of telangiectases as well as facial rhytides reduction. the existing lasers are based on a wavelength that is specifically absorbed by the chromophore found in the target such as hair follicle, where the energy is converted to heat resulting in a thermal injury. however, the lasers for cosmetic treatments are not without limitations. a laser based long-term hair removal treatment is based on thermal destruction of the hair shaft and follicle using wavelengths that are specifically absorbed by the pigment melanin found in the hair follicle. the heating of hair follicle is done through heat dissipation from the hair shaft. one of the significant limitations of this approach is the fact that the epidermis through which the light energy must penetrate is rich in melanin and therefore absorbs a major portion of the energy, resulting in inadequate heating of the hair follicles. similar problem exists when targeting other chromophores such as hemoglobin or water. the purpose of the study is an evaluation of safety and efficacy of a new laser based device.

Eligibility criteria:
inclusion criteria: * age between 18 and 75 years old * fitzpatrick skin types i to vi * unwanted hair or/and * aesthetically disturbing vascular lesions or/and * facial rhytides exclusion criteria: * age below 18 or above 75 year old. * use of photosensitive medications * photosensitive diseases * active infection of any type and active infection or or a history of herpes simplex in the treated site * exposure to sun or artificial tanning during the last 3-4 weeks * for treatment of facial rhytides- surgical or nonsurgical facial procedure (i.e., laser skin resurfacing, dermabrasion, phenol peel, nonablative laser, or temporary/permanent filler (e.g., collagen, fat, hyaluronic acid injections)
treating opioid misuse via mindfulness-based just-in-time adaptive intervention

Conditions: Chronic Pain

Summary: this pilot rct will examine the preliminary efficacy of a telehealth version of mindfulness-oriented recovery enhancement (more) enriched with a smartphone-based just-in-time adaptive intervention (jitai) for patients with chronic pain on long-term opioid therapy.


Eligibility criteria:
inclusion criteria: * current chronic pain diagnosis determined by physician assessment (including but not limited to icd-9 diagnoses 338.0, 338.21, 338.22, 338.28, 338.29, 338.4) * current use of prescription opioid agonist or mixed agonist-antagonist analgesics for \>90 days * willingness to participate in study interventions and assessments exclusion criteria: * prior experience with mindfulness-based stress reduction, mindfulness-based cognitive therapy, or mindfulness-based relapse prevention * active suicidality, schizophrenia, psychotic disorder * presence of clinically unstable systemic illness judged to interfere with treatment * no access to internet (which will prevent telehealth-based treatment)
follow-up of apneic patients by visio-consultation

Conditions: Obstructive Sleep Apnea

Summary: prospective multicenter open-label randomized clinical trial comparing videoconsultation to a face-to-face consultation during the follow-up of apneic patients treated by continuous positive pressure (cpap) .

the annual management of obstructive sleep apnea (osa) patients treated by continuous positive air pressure (cpap) aims to maintain an optimal level of care while offering to the patients a combined management of their pathology. this management aims to reduce the risk of cardio-metabolic pathologies. however, the high prevalence of osa in the general population reduces the ability to explore undiagnosed patients. the contribution of videoconsultation is now available and allows the management of osa patients treated by cpap. the objective of this study is to compare the videoconsultation to a face-to-face consultation during the follow-up of apneic patients treated by continuous positive pressure (cpap) . the results of this study could provide very important new data on the impact of videoconsultation on the monitoring a chronic respiratory pathology such as sleep apnea.

Eligibility criteria:
inclusion criteria: * apneic patient treated with cpap for more than 12 months and having an annual scheduled follow-up visit. * adult patient who can give an informed consent. * patient with access to a media (smartphone, tablet or computer) and an internet connection at home. exclusion criteria: * patient unable to use or understand the digital system. * patient under guardianship or deprived of liberty * pregnant woman * patient in a period of exclusion from another clinical trial

Keywords: telemedicine medical follow-up
the genetics of cardiomyopathy and heart failure

Conditions: Dilated Cardiomyopathy; Hypertrophic Cardiomyopathy; Mitochondrial Cardiomyopathy; Noncompaction Cardiomyopathy; Restrictive Cardiomyopathy

Summary: the purpose of this study is to determine the genetic basis of cardiomyopathies and heart failure.

the purpose of this research study is to explore the causes and inheritances of cardiomyopathies. cardiomyopathies are serious medical conditions that result in a wide range of cardiac problems, from no symptoms at all to heart failure. the underlying genetics of cardiomyopathies are poorly understood. this study will collect personal, family, and medical history information to create a database of participants with cardiomyopathies. this information will be used to identify inheritance patterns within families with cardiomyopathies. in addition, samples from participants will be studied in the lab to see if any changes in their genetic information can be identified that would cause a cardiomyopathy. overall, the research study is aimed at determining the cause of these cardiac conditions so that tests and treatments might be developed in the future.

Eligibility criteria:
inclusion criteria: * individuals with a diagnosis of cardiomyopathy * family members of individuals with a diagnosis of cardiomyopathy * individuals with a nuclear mutation shown to confer risk of cardiomyopathy but who do not themselves have cardiomyopathy exclusion criteria: * individuals who do not have cardiomyopathy, a relative with cardiomyopathy, or a nuclear mutation predisposing to cardiomyopathy

Keywords: genetics dilated cardiomyopathy hypertrophic cardiomyopathy mitochondrial cardiomyopathy noncompaction cardiomyopathy restrictive cardiomyopathy heart failure