Kornimate/medical-research-clean huggingface dataset:
68ga-dotatate pet/ct for the diagnosis of soft tissue sarcomas

Conditions: Soft Tissue Sarcoma

Summary: this trial studies how well 68ga-dotatate digital pet/ct work in diagnosing soft tissue sarcoma. 68ga-dotatate is a radiotracer that may improve image quality of pet imaging. pet is an established imaging technique that utilizes small amounts of radioactivity attached to very minimal amounts of tracer, in the case of this research, 68ga-dotatate. ct images provide an exact outline of organs and potential inflammatory tissue where it occurs in patient's body. 68ga-dotatate digital pet/ct may work better in imaging patients with soft tissue sarcomas.

primary objective: i. to assess the feasibility and capability of gallium ga 68-ha-dota-tate (68ga-dotatate) digital positron emission tomography (dpet)/ computed tomography (ct) imaging for soft tissue sarcomas. secondary objectives: i. to evaluate the clinical benefit of 68ga-dotatate for a comprehensive assessment of soft tissue sarcomas (sts) using next-generation digital pet detector technology. ii. to describe the perfusion and early tumor uptake kinetics of tumor targets at baseline and following conventional systemic therapy using both 68ga-dot at a te dpet/ct and 18f-fdg dpet/ct approaches. iii. using list-mode dpet acquisitions following standard 68ga-dotatate dose administrations, imaging datasets will be retrospectively generated to simulate lower dose or faster image acquisition in order to define further the minimum 68ga-dotatate dose and pet image acquisition times needed to maintain lesion detectability and pet quantification. v. to assess the feasibility for 68ga-dotatate dpet/ct to identify and stratify sts patients with sstr2-positive soft tissue sarcoma lesions for future therapy planning using 177lu-dotatate peptide receptor radionuclide therapy (prrt) for patients with 68ga-dotatate-avid sarcomas. vi. to assess the safety of 68ga-dotatate in this patient population. outline: patients receive gallium ga 68-ha-dota-tate intravenously (iv) and undergo dpet/ct over 60 minutes up to two weeks after starting standard chemotherapy. beginning 24 hours after gallium ga 68-ha-dota-tate dpet/ct, patients also receive fludeoxyglucose f-18 iv and undergo dpet/ct over 60 minutes.

Eligibility criteria:
inclusion criteria: * patients \>= 18 years of age * patients diagnosed with any stage of soft tissue sarcomas candidates for systemic therapies * patients with one standard of care pet/ct scan up to 30 days before enrollment at the ohio state university facilities. exclusion criteria: * hypersensitivity to somatostatin or similar peptides * somatostatin long-acting analog in the past 6 months * patients who are pregnant or lactating * patients who are currently incarcerated * patients with acute infections * inability to complete the needed investigational and standard-of-care imaging examinations due to other reasons (severe claustrophobia, radiation phobia, etc.) * patients exceeding the weight limitations of the scanner or are not able to enter the bore of the dpet/ct scanner due to body mass index (bmi)
mindfulness-based neurofeedback to augment psychotherapy for adults with borderline personality disorder

Conditions: Borderline Personality Disorder

Summary: the purpose of this study is to test the ability of mindfulness-based real time functional magnetic resonance imaging (fmri) neurofeedback (mbnf) to increase the benefits of evidence-based psychotherapy for adults with borderline personality disorder (bpd).

the focus of this study is aim 1.

Eligibility criteria:
inclusion criteria: * age 18-60, * be able to provide written informed consent, * meet criteria for bpd on semi-structured clinical interview, * able to plan to keep any prescribed medications and psychotherapy constant during the study * fluent in english. exclusion criteria: * current dbt psychotherapy outside the study * lifetime primary psychotic disorder or bipolar i disorder * developmental disorder (e.g. autism) * history of learning disorder * moderate or severe substance use disorder in the last 6 months * active suicidal ideation with intent or plan in the past 3 months * history of major medical or neurologic disorder * mri contraindications, including pregnancy * poor performance on reading task (wrat \> 11 errors) * newly prescribed medications in the past 8 weeks * daytime sedating medications (e.g. benzodiazepines, opiates, sedating neuroleptics) * any scheduled daily benzodiazepines * change in psychotherapy type or frequency in the past 12 weeks. * at the discretion of the study pi eligibility will be determined by study personnel.

Keywords: fmri neurofeedback mindfulness
the effect of progressive muscle relaxation on psychological symptoms and mental well-being in patients with schizophrenia

Conditions: Schizophrenic Psychoses

Summary: schizophrenia is a mental illness that progresses with delusions or hallucinations, causes changes in interpersonal communication, thoughts and behaviors, continues with recovery and repetitions, and in which the interpretation of reality is impaired. drug treatment alone is not sufficient in schizophrenia, and it is known that negative symptoms continue even in patients with a good response to drug treatment. for this reason, complementary therapies, psychosocial approaches and rehabilitation in addition to drug therapy increase the effectiveness of the treatment.

schizophrenia is a mental illness that progresses with delusions or hallucinations, causes changes in interpersonal communication, thoughts and behaviors, continues with recovery and repetitions, and in which the interpretation of reality is impaired. drug treatment alone is not sufficient in schizophrenia, and it is known that negative symptoms continue even in patients with a good response to drug treatment. for this reason, complementary therapies, psychosocial approaches and rehabilitation in addition to drug therapy increase the effectiveness of the treatment.it is seen that the tension, the effects of stress, the state of anxiety, blood pressure, heart rate, lactic acid production, sensitivity to pain are reduced by performing relaxation exercises in a suitable environment, regularly and in accordance with the technique. helps you think positively studies involving patients with schizophrenia have also proven the beneficial effect of progressive relaxation, with positive changes observed through relieving anxiety, reducing psychological stress, and increasing psychological well-being.

Eligibility criteria:
inclusion criteria:• being 18 years or older, * having a confirmed diagnosis of schizophrenia for at least 6 months * having the ability to communicate and read, * volunteering to participate in the research. exclusion criteria:• being closed to communication, * not complying with the principle of voluntarism * patients in acute exacerbation period

Keywords: schizophrenic relaxation exercise nursing psychological symptoms
scalp acupuncture combined rtms on brain white matter microstructure of hemiplegic patients with stroke

Conditions: Stroke

Summary: to apply bold-fmri technology to observe and compare the differences of task-related activation of relevant brain cortex region in stroke hemiplegic patients and healthy subjects after finger grasping movement.

stroke is one of the common cerebrovascular diseases. with the improvement of medical conditions and treatment technology, the death rate of stroke patients has declined, but the disability rate has increased. in china about 50%-70% of stroke patients have the residual sequelae such as paralysis, paralalia dysfunction and so on. hemiplegic is the most frequent sequelae in post-stroke patients, finger movements recovery has already became the most difficult question in all the movement kinematics and dynamics rehabilitation,which affects the total movement function and ability of daily life in the patients.the finger recovery is tightly related to the neural plastic and brain function realignment.furthermore, whether the special brain movement functional cortex area in bilateral hemispheres can be effectively activated is the crucial solved link. a number of recent literature have displayed the special brain motor area including the primary motor cortex(m1), the supplementary motor area(sma), the premotor area(pma), the primary sensorimotor area(sm1),the secondary area(sm2), the cingulate sulcus area(cma) and the cerebellum hemispheres(cb). however，the study on the above-mentioned motor area synchronously activated when the patients after systematically rehabilitative treatment performed fingers grasping task was reported rarely. bold-fmri technology is a new brain functional imaging technology developed on the basis of mri in 1990s, which not only retains the anatomical imaging characteristics of ordinary mri, but also obtains the physiological information. the emergence of bold-fmri technology provides a new way to study the mechanism, evaluation and prognosis of stroke rehabilitation, and it shows a good research and clinical application value in the field of rehabilitation medicine.

Eligibility criteria:
inclusion criteria: * at the same time in accordance with ischemic stroke of chinese and western medicine diagnostic criteria; * the first time stroke, unilateral stroke or once attack but not remnant nerve dysfunction; * stable vital signs and clear consciousness; * unilateral upper limb brunnstrom evaluation; * age from 30 to 60 years; * the course of disease was within 1 year. exclusion criteria: * a history of epilepsy; * the important organs function failed such as heart, lung, liver and kidney; * serious cognitive impairment and poor compliance; * wearing a pacemaker、intracranial metal implants, or with skull defects; * serious cervical spine including cervical stenosis and instability of cervical spine; * women during pregnancy; * patients cannot tolerate fmri study.
covid-19 pandemic and medical students

Conditions: the Effect of COVID-19 Pandemic

Summary: little is known about changes in levels of academic, financial, psychological, \& hygienic impact on medical students during this pandemic.

this is a cross-sectional, questionnaire-based study. it is conducted on a random targeted sample of medical students at medical schools in universities of jordan, classified by their academic years (from the 1st to the 6th academic year). a score of 10 points was constructed to reflect the perspective about the items in each group of variables. spss version 25.0 was used for the statistical analysis.

Eligibility criteria:
inclusion criteria: * medical students in the basic and clinical years exclusion criteria: * inability to complete the questionnaire
comparison of ostap and eoip blocks in laparoscopic cholecystectomies

Conditions: Analgesia; Pain, Post Operative

Summary: laparoscopic cholecystectomy (lc) surgery causes postoperative severe pain. as part of multimodal analgesia aimed at reducing postoperative opioid consumption and providing effective analgesia, ultrasound (us)-guided transversus abdominis plane block (tap) and external oblique intercostal plane block (eoipb) will be applied as regional anesthesia methods. there is no study in the literature comparing ostap and eoip blocks, and our goal is to evaluate the analgesic effectiveness between ostap and eoip blocks in lc surgeries.

patients will be divided into two groups, and general anesthesia will be administered to all. before extubation, one group will receive an external oblique intercostal nerve block, while the other group will receive an oblique subcostal transversus abdominis plane block. the randomization of the study will be carried out by a computer-generated randomization code (computer-generated) by a physician who will not be involved in patient follow-up. the interfascial plane block (either external oblique intercostal block or oblique subcostal block) will be provided to an anesthesiologist in a sealed envelope by an independent assistant staff member outside the study. the patient will not be aware of which block is applied. the anesthesiologist performing the block will not participate in the pain follow-up of the patients. postoperative pain assessment and data collection will be conducted by another anesthesiologist unaware of the study. for standardization, the block procedure will be performed by an experienced anesthesiologist who has completed at least 20 previous successful and uncomplicated procedures.

Eligibility criteria:
inclusion criteria: * bmi \< 35 kg/m² patients with asa scores i and ii exclusion criteria: * patients who do not want to be included in the study psychiatric and neurological disease with blurred consciousness patients with asa \> 3 bmi \> 35 kg/m² abnormality in coagulation parameters history of allergy to local anesthetic drugs infection at the injection site

Keywords: laparoscopic cholecystectomy oblique subcostal transversus abdominis plane block external oblique interfascial plane block
effect of rowachol on prevention of postcholecystectomy syndrome

Conditions: Postcholecystectomy Syndrome

Summary: postcholecystectomy syndrome (pcs) includes a heterogeneous group of diseases, usually manifested by the presence of abdominal symptoms following gallbladder removal. the pathogenesis of pcs has not been identified; therefore there is no consensus of medical treatment on pcs. the action of rowachol are to inhibit hepatic 3-hydroxy-3-methylglutaric acid(hmg)-coenzyme a(coa) reductase, to inhibits cholesterol nucleation in bile from patients with cholesterol gallstones, and to promote biliary lipid secretion. the purpose of this study is to determine whether rowachol is useful in the prevention of pcs and symptoms change after laparoscopic cholecystectomy


Eligibility criteria:
inclusion criteria: * patients with pathologic diseases scheduled for laparoscopic cholecystectomy exclusion criteria: * current immunosuppressive therapy * chemotherapy within 4 weeks before operation * radiotherapy completed longer than 4 weeks before operation * inability to follow the instructions given by the investigator * severe psychiatric or neurologic diseases * drug- and/or alcohol-abuse according to local standards * participation in another intervention-trial with interference of a primary or secondary endpoint of this study * lack of compliance * lack of informed consent

Keywords: postcholecystectomy syndrome laparoscopic cholecystectomy rowachol
the efficacy of papaverine to prevent radial artery spasm during transradial cerebral angiography

Conditions: Radial Artery Spasm

Summary: rationale:papaverine is effective on radial artery spasm during transradial cerebral angiography. purpose: this multicenter, randomized, placebo-controlled, double blind, phase 2b trial aims to investigate the effect and safety of papaverine in treating radial artery spasm during transradial cerebral angiography.

radial artery spasm (ras) is a common complication during transradial cerebral angiography. ras can lead to severe pain and remains the most frequent cause of transradial angiography failure. there is currently no consensus on the prevention strategy for ras. papaverine has anti vasospasm, sedative and analgesic effects. however, there is no evidence for the efficacy of papaverine in preventing ras. this multicenter, randomized, double blind, placebo-controlled trial aims to investigate the effect and safety of papaverine in treating radial artery spasm during transradial cerebral angiography.

Eligibility criteria:
inclusion criteria: 1. all patients scheduled for cerebral angiography will be eligible for screening. 2. participant is willing and is able to give informed consent for participating in the trial. 3. male or female, aged 18 years or above. exclusion criteria: 1. any patient with negative modified allen test 2. altered liver function 3. atrioventricular heart block iii degree 4. suspected or confirmed cerebral hemorrhage patients 5. hemodynamic instability : systolic pressure \ 100 bpm, tachycardia uncontrollable. 6. patients with cerebral edema and increased intracranial pressure within 24 hours to 2 weeks after stroke 7. coronary artery bypass grafting(cabg) operation history and whose right radial artery is missing as a "bridge vessel" 8. severe skin musculoskeletal malformation of forearm or failure to complete radial artery puncture and sheath placement for other reasons 9. hypersensitivity or contraindication to papaverine 10. hypersensitivity or contraindication to nitroglycerine 11. glaucomatous patients 12. parkinson's disease patients 13. women who are suspected or known to be pregnant or breastfeeding

Keywords: radial artery spasm papaverine cerebral angiography
a study evaluating the safety, pharmacokinetics, and activity of ro7656594 in participants with advanced or metastatic prostate cancer

Conditions: Advanced Prostate Cancer; Metastatic Prostate Cancer

Summary: the purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and preliminary activity of ro7656594 in participants with advanced or metastatic prostate cancer. it will also identify recommended doses and regimens for ro7656594 for subsequent studies.


Eligibility criteria:
key inclusion criteria: 1. eastern cooperative oncology group (ecog) performance status ≤1. 2. metastatic prostate adenocarcinoma without small-cell carcinoma or neuroendocrine features. 3. prior therapy with a second-generation androgen receptor (ar)-targeted therapy (e.g., abiraterone, enzalutamide, apalutamide, darolutamide). 4. prior therapy with a taxane regimen or are considered ineligible for treatment with a taxane regimen or have refused treatment with a taxane regimen, unless otherwise specified. 5. for participants with a known pathogenic breast cancer gene 1 (brca1) or brca2 mutation: prior therapy with a poly (adenosine diphosphate (adp)-ribose) polymerase (parp) inhibitor, or are considered ineligible for treatment with a parp inhibitor, if such therapy is approved and available. key exclusion criteria: 1. treatment with any approved systemic anti-cancer therapy within 14 days or 5 drug elimination half-lives (whichever is longer, not to exceed 28 days) prior to the first study treatment. 2. treatment with any investigational agent within 28 days prior to the first study treatment. 3. treatment with any previous ar protein degrader. 4. untreated central nervous system (cns) metastases or leptomeningeal disease. note: other protocol specified inclusion/exclusion criteria may apply.

Keywords: castration-resistant
long term outcome of intravitreal ranibizumab for rop

Conditions: Retinopathy of Prematurity

Summary: premature infants who had a history of intravitreal injection of (ranibizumab) not less than one year were examined for refractive state and biometry

medical records were collected in each group for birth history data, including gestational age (ga), birth weight (bw), and postmenstrual age (pma) at time of intravitreal injection. the zone and stage of rop were also recorded. all patients were evaluated for refractive errors and cycloplegic refraction was performed using a handheld auto keratorefractometer (righton retinomax k-plus2), and confirmed by retinoscopy examination. refractive errors were calculated as spherical equivalent and astigmatism in cylinder. the average corneal radius of curvature was measured by handheld auto kerato-refractometer (righton retinomax k-plus2). the biometric optic components, including anterior chamber depth, lens thickness, and axial length, were measured using a-scan ultrasound (model echoscan us-4000 / 500; nidek)

Eligibility criteria:
inclusion criteria: * premature infants who had a history of intravitreal injection of (ranibizumab) not less than one year * three control groups with age and sex matched were included for comparison. first group included premature infants who had rop that regressed spontaneously without intervention. second group was corresponded to premature infants who were diagnosed to have normal retinal vasculature from the first examination after birth. the third group belonged to full term babies exclusion criteria: * premature infants who received intravitreal injection of (ranibizumab) less than one year or had any ocular pathology
effect of russian current stimulation for anterior tibial group on postural stability and risk of falling in patients with stroke

Conditions: Stroke

Summary: this study aimed to examine the effect of russian current stimulation on anterior tibial group on postural stability and risk of falling in patients with stroke.

stroke is the second leading cause of death globally and the main cause of disability, with ischemic strokes accounting for about 87% of cases. in 2010, over 11 million ischemic strokes occurred, predominantly in low and middle-income countries, leading to approximately three million deaths. hemorrhagic strokes account for 13% of cases. egypt, with an estimated population of 85.5 million, has a high stroke prevalence of 963 per 100,000 inhabitants. postural imbalance is a common limitation, affecting 83% of acute stroke patients, and falls are frequent across all stages of recovery, with rates as high as 73% within six months post-discharge. even in chronic stroke patients, the fall risk remains elevated compared to age-matched controls. postural imbalance impacts quality of life, and rehabilitation is vital for regaining independence in daily activities. up to 30% of stroke survivors experience significant permanent disabilities, and 20% require rehabilitation. motor impairments, particularly in the lower limbs, limit daily activities, community participation, and quality of life. poor lower-limb muscle performance affects balance, gait, and functionality, but interventions like russian current have shown effectiveness in improving walking performance and motor recovery in chronic stroke survivors.

Eligibility criteria:
inclusion criteria: * forty patient with stroke manifest with weakness of anterior tibial group. * patients with moderate spasticity, * patient's ages ranged from 40-55 years. * patients bmi not exceed 30 kg/m². * medically and clinically stable patients. exclusion criteria: * patients suffering from psychological, cognitive, or emotional disturbance. * patients with severe spasticity (3 or more by the modified ashworth scale). * patients with atrial fibrillation. * patients with infectious processes. * patients with impaired pain sensitivity. * patients with epilepsy. * patients with lower limb joint endoprosthetics.
the effects of transcranial direct current stimulation on central pain in patients with spinal cord injury

Conditions: Neuropathic Pain; Spinal Cord Injury

Summary: the purpose of this study is to evaluate the analgesic effect of transcranial direct current stimulation (tdcs) applied on motor cortex in patients with spinal cord injury who have chronic neuropathic pain.

* anodal stimulation of the primary motor cortex (m1) * anode electrode: c3 (eeg 10/20 system) * cathode electrode: contralateral supraorbital area * constant current of 2ma intensity for 20 min * twice a day with a more than 4 hours interval during of 2 weeks (from monday to friday, total 20 treatment session)

Eligibility criteria:
inclusion criteria: * elapsed time since spinal cord injury more than 6 months * stable chronic pain for at least 3 preceding months * pain that was not attributable to cause other that neuropathic pain * pain that was resistant to various types of medications or physical or complementary medicine treatment exclusion criteria: * any kind of metal implant in the head * heart disease including having a cardiac maker * family or personal history of epilepsy, or neuropsychiatric illness