Kornimate/medical-research-clean huggingface dataset:
expanded breast cancer registry and tissue repository

Conditions: Breast Cancer

Summary: the expanded breast cancer registry and tissue repository research team (ebcr-rt) is comprised of university of mexico comprehensive cancer center faculty and staff whose goals are to improve the outcomes and quality of life of patients with breast cancer, and ultimately to eradicate and cure breast cancer. one focus of the ebcr-rt is the creation an infrastructure that can potentially be adopted as a model for a statewide registry and tissue repository for the discovery of biomarkers for this disease. the goals of the ebcr are: 1. to register patients diagnosed with breast cancer and information relevant to their diagnosis (such as stage, grade, hormone receptor status, etc), treatment (surgery, radiation, chemotherapy, hormone therapy, etc), and survivorship (quallity of life, etc). 2. to collect relevant demographics including age, menopausal status, race/ethnicity, body mass index (bmi), place of residence, behaviors (smoking, alcohol intake, etc) 3. to establish a paired tumor tissue and blood sample for each relevant time-point (as defined in the protocol), which will be stored in the tissue bank shared resource facility for future hypothesis-driven research.

institutions and/or physicians are required to report each new diagnosis of breast cancer to the new mexico tumor registry (nmtr). the nmtr is a valuable database that provides information on breast cancer, including trends in incidence and survival. however, relevant information on breast cancer prognosis and treatment is either not routinely collected or not readily available to the nmtr. we propose to establish an expanded breast cancer registry and tissue repository (ebcr) at this institution that could serve as an infrastructure for collection of this information. furthermore, a tissue bank will be established for collection of paired tissue (tumor, buccal cells and blood sample) from patients diagnosed with breast cancer who consent to providing excess/extra tissue and additional blood for the tissue repository. this tissue bank will serve as a repository from which researchers can access tissue samples to conduct laboratory-based studies of genetic determinants of breast cancer risks, prognosis and survival in women with breast cancer seen in this institution.

Eligibility criteria:
inclusion criteria: * all patients diagnosed with breast cancer, regardless of gender, ethnicity/race, stage of disease or treatment, are eligible. * patients must be less than or equal to one year from diagnosis of non-metastatic breast cancer or less than or equal to one year from initiation of treatment for metastatic disease. * pathological diagnosis of breast cancer * expected availability of clinical follow up data * eighteen years old or older * participants must be willing to provide written, informed consent obtained in accordance with institutional and federal guidelines exclusion criteria: * not specified.

Keywords: breast cancer risk factors treatment clinico-pathologic outcomes tissue repository registry
effectiveness of a structured intervention to optimize the use of mirabegron

Conditions: Overactive Bladder Syndrome

Summary: this study was a multicentre, quasi-experimental design, controlled, before-and-after trial to estimate the effectiveness related to the review of mirabegron use and, if appropriate, its discontinuation. intervention group: patients with mirabegron prescription assigned to any of the 17 primary health care centers (phc) located in the northern area of barcelona. control group: all the other patients assigned to any of the other 34 health care centers in barcelona belonging to the catalan institut of health (cih). the structured intervention included initiatives with general practitioners and urologists/gynaecologists, management support from health care authorities, and monthly feed-back monitoring to general practitioners (gps). the follow-up period was 12 months, from january 1st to december 31st, 2017.

a quasi-experimental design with before/after measurement and a control group was used. the objective was to identify the effectiveness of a training activity on the review of treatments. in addition, it was proposed to establish the duration of medication in real clinical practice, and its prevalence of use before and after the intervention. control group: usual care intervention: * initiatives for healthcare professionals: information and training with written material, in an diagram format, distributed to all general practitioners. * initiatives for specialized hospital care: information regarding the intervention for urologists and gynaecologists. * management support with the definition of a structured strategy for all the addresses of the phc and gps. * monthly monitoring of the intervention (feed-back to all gps). the intervention consisted of: a) meetings with all the directors of the phc; b) informative meetings and sessions in the phc; c) distribution of the diagram to all the gps; d) lists of patients with treatment provided periodically from the medication area; and e) review of the treatments by the gps. if considered appropriate, and with the consent of the patient, the medication was withdrawn. a pharmacist and a clinical pharmacologist acted as consultants in case of any doubts regarding specific patients.

Eligibility criteria:
inclusion criteria: * patients ≥ 18 years with mirabegron prescription. the prescription could be performed by a hospital or primary care doctor. exclusion criteria: * patients under 18 years

Keywords: overactive bladder mirabegron persistence patient-centered care inappropriate prescribing discontinuation
hippocampal stimulation in chronic low back pain

Conditions: Chronic Pain; Back Pain; Pain

Summary: in this study the investigators aim to examine the effects of transcranial magnetic stimulation (tms) on hippocampal network connectivity and pain levels in individuals with chronic low back pain.


Eligibility criteria:
inclusion criteria: * ≥ 6 months of back pain on a daily basis; * male or female with no racial or ethnic restrictions; * 18 to 75 years old; * average back pain intensity \> 4/10 at study entry; * must be able to read, understand, and sign consent form; * generally healthy. exclusion criteria: * back pain with fever, chills, rheumatoid arthritis, ankylosing spondylitis, acute vertebral fractures, * history of tumor in the back; * back surgery within the past 6 months; * chronic neurologic conditions, e.g., parkinson's * involvement in litigation regarding back pain; * other severe medical diseases; * pregnancy; * positive urinary screen for any recreational drugs, * opioids use; * use of anticoagulants (low dose asa allowed); * history of gastric ulcer; renal insufficiency or congestive heart failure, * contraindication to mri, * contraindication to tms; including history of seizure/epilepsy\* * any medical condition that in the investigator's judgment may prevent the individual from completing the study or put the individual at undue risk; * in the judgment of the investigator, unable or unwilling to follow protocol and instructions; * diagnosis of major depression; * intra-axial implants (e.g. spinal cord stimulators or pumps)

Keywords: transcranial magnetic stimulation resting state mri
internet treatment for social phobia in romania

Conditions: Phobia, Social

Summary: the main aim of this study is to investigate the effectiveness of an internet-delivered intervention for social phobia by comparing it to a waitlist control group. the second aim of the study is to track the potential changes in participants' thinking patterns. because this is among the first guided internet-delivered interventions conducted in romania, the treatment credibility will also be investigated. finally, the predictive power of anxiety sensitivity for both sad symptoms and the treatment effectiveness will be investigated.

the primary aim of this study is to investigate the effectiveness of an internet intervention for social phobia (i.e., the isofie) by comparing it to a waitlist control group. isofie was derived from a previously tested program (furmark, holmström, sparthan, carlbring, \& andersson, 2006) and has been significantly shortened while retaining the most important elements. the second aim of the study is to track the potential changes in participants' thinking patterns. while this intervention is primarily based on the cognitive-behavioral model of sad (clark and wells, 1995), and no specific rational emotive behavior therapy (rebt, ellis \& dryden, 1997) will be implemented, it is hypothesized that the cognitive restructuring and exposure exercises will make participants less prone to irrational thinking (as measured by the attitude and belief scale-ii (abs-ii, digiuseppe, leaf, exner, \& robin, 1988). to our knowledge, no study has investigated whether an icbt program for sad has the potential to alter participants' irrational thinking patterns. moreover, because this is among the first guided internet-delivered interventions conducted in romania, the treatment credibility of the program will be investigated. finally, the predictive power of anxiety sensitivity for both sad symptoms and the treatment effectiveness will be investigated.

Eligibility criteria:
inclusion criteria: * over 18 years * social anxiety disorder is the primary diagnostic (according to the dsm-iv) * access to an internet connected computer * be fluent in romanian language exclusion criteria: * suicidal ideation * ongoing psychological treatment for social anxiety disorder * recent change in psychiatric medication (i.e., during the last 6 weeks) * psychoses or borderline personality disorder

Keywords: social anxiety disorders social phobia anxiety sensitivity irrational thinking guided self-help internet-delivered treatment
we collected blood samples from septic shock patients and measured elabela, creatinine, and ngal levels. survival after 7 days was recorded and analyzed to evaluate the potential of serum elabela as an early diagnostic marker for sepsis-associated acute kidney injury.

Conditions: Sepsis; Septic Shock; Acute Kidney Injury

Summary: the investigators selected patients diagnosed with sepsis who were admitted to the intensive care unit (icu) of huai'an first people's hospital between june 2022 and december 2023, as well as healthy individuals with normal kidney function during the same period, for the research. the investigators collected blood samples from patients with septic shock or sepsis at 6 hours, 12 hours, 24 hours, 48 hours, 3 days, 5 days, and 7 days after diagnosis， and also collected blood samples from the healthy individuals. the blood samples were stored in gel separation vacuum tubes containing heparin as an anticoagulant. the supernatant was removed and stored at -80°c, and the levels of plasma ela (enzyme-linked immunosorbent assay) were measured using a standardized ela kit. additionally, serum ngal (neutrophil gelatinase-associated lipocalin) and creatinine levels were measured simultaneously. the subjects were divided into three groups based on the kdigo diagnostic criteria: sepsis-associated acute kidney injury (s-aki) group, sepsis non-aki group, and normal control group. finally, the data were analyzed to determine the early diagnostic value of ela for s-aki. approximately 70 specimens were collected in total.


Eligibility criteria:
inclusion criteria: patients with sepsis admitted to the icu. exclusion criteria: 1. under 18 years old; 2. history of chronic kidney disease; 3. recipients of organ transplantation within the past year; 4. patients or their families could not give informed consent.

Keywords: sepsis associated acute kidney injury elabela
plasma glucagon-like peptide-1 levels and acute myocardial infarction

Conditions: Coronary Angiography; Glucagon-like Peptide-1

Summary: glp-1(9-36) amide and (9-37), which was previously thought to be the inactive metabolite of glp-1, also exerts cardioprotective effects. direct administration of glp-1(9-36) during reperfusion reduced ischaemic damage in isolated hearts and increased cgmp release, vasodilatation and coronary flow in ami mouse model, one may speculate that total glp-1 level may associate with adverse cardiovascular events in ami patients, the hypothesis is therefore tested in this study.


Eligibility criteria:
inclusion criteria: * consecutive patients of acute ami come to our department,absent of cardiogenic shock, and survival for at least 24 h after pci treatment. exclusion criteria: * patients with cancer, and patients who were taking a dpp4 inhibitor or a glucagon-like peptide-1 (glp-1) analogue
surgery for delay-recognized or defer-operated type a aortic dissection

Conditions: Aortic Dissection

Summary: from november 2004 to june 2020, there were more than 200 patients with acute taad patients who underwent aortic surgery at our hospital.of all the patients in the study period, there were 34 patients (defined as study group) who sought for medical attention with symptoms for several days (median 5 days, range 3-7 days) or deferred aortic surgery several days later (median 3 days, range 2-7 days) even though acute taad was diagnosed on the same day when chest pain or back pain occurred. for reducing the selection bias, propensity score matching (psm) was used to match the study group with the control group from all the patients treated at our hospital during the study period. comparison between the two groups was performed.

from november 2004 to june 2020, there were more than 200 patients with acute taad patients who underwent aortic surgery at our hospital. the research protocol used in this study was approved by the institutional review board of mackay memorial hospital (irb number: 21mmhis005e). of all the patients in the study period, there were 34 patients (defined as study group) who sought for medical attention with symptoms for several days (median 5 days, range 3-7 days) or deferred aortic surgery several days later (median 3 days, range 2-7 days) even though acute taad was diagnosed on the same day when chest pain or back pain occurred. the mean age at presentation was 60.2 +/- 13.2 years (range 33.4\~83.5 years). all the patients in the study group were divided into 3 groups: dp group (n=22) with acute taad diagnosis delayed by patient but received prompt aortic surgery; dd group (n=4) with acute taad diagnosis delayed by patient and received deferred aortic surgery; id group (n=8) with acute taad diagnosis on the same day when the symptoms occurred but received deferred aortic surgery several days later. for reducing the selection bias, propensity score matching (psm) was used to match the study group with the control group from all the patients treated at our hospital during the study period. comparison between the two groups was performed.

Eligibility criteria:
inclusion criteria: * the patients sought for medical attention with symptoms (chest pain, back pain or shortness of breath) for several days or deferred aortic surgery several days later although acute taad was diagnosed on the same day when chest pain or back pain occurred exclusion criteria: -
initiating substance use disorder treatment for hospitalized opioid use disorder patients.

Conditions: Opioid-use Disorder

Summary: the purpose of this 24-week study is to evaluate the impact of recovery coach intervention on rates of treatment retention, illicit opioid use, and readmission among hospitalized patients newly initiated on buprenorphine or methadone compared to the control intervention.

patients with opioid use disorder (oud) frequently utilize hospitals due to soft tissue infections and other conditions that require inpatient level of care. prior studies have indicated that oud patients are often amenable to initiating buprenorphine treatment and can be successfully linked to outpatient treatment. however, hospitalized oud patients initiated on buprenorphine have much lower treatment retention rates at 6-months compared to oud patients initiating treatment in the outpatient setting. as such, there is a great need to identify strategies to improve treatment retention in this patient population. there is a growing body of evidence for the benefits of recovery coaches, who provide peer-delivered support services in the community. tracing their origin to mutual support groups to supplement traditional clinical services, recovery coaches are individuals with lived experience of recovery. studies of recovery coaches have demonstrated greater treatment retention, reduced substance use, and reduced inpatient utilization. however, no prior studies have examined the impact of recovery coaches in improving medication-assisted treatment retention. as such, the aim of this 24-week study is to evaluate the impact of recovery coach intervention on rates of treatment retention, illicit opioid use, and readmission among hospitalized patients newly initiated on buprenorphine or methadone compared to the control intervention. patients who are successfully initiated on buprenorphine or methadone, and are willing to engage in treatment after discharge, will be eligible to enroll. assessments will be conducted at baseline, 4 weeks, 12 weeks, and 24 weeks.

Eligibility criteria:
inclusion criteria: * english speaking, adults aged 18-75 * diagnostic and statistical manual of mental disorders, 5th edition (dsm-5) diagnosis of opioid use disorder, severe, actively using illicit opioids until the time of hospitalization * have a working telephone * can identify at least 2 individuals who can act as points of contact following discharge from the hospital * willing to engage in treatment (either a psychosocial treatment program and/or medication treatment with methadone or buprenorphine) exclusion criteria: * liver function test \>3x upper normal limit * pregnant * psychotic disorder, active suicidality or homicidality * condition likely to be terminal in 24 weeks such as cancer * unable to perform consent due to mental status * engaged in substance abuse treatment in the last month prior to admission
implementation of clinical pathway to improve quality of healthcare in stroke inpatients

Conditions: Stroke

Summary: with the extension of the average life expectancy, the incidence of cardiovascular diseases is also rising. stroke in taiwan has been the leading cause of morbidity and mortality, but also in countries around the world), stroke and the impact of socio-economic and health spending are large how to reduce the degree of disability after stroke is an important issue in medicine. for a long time, the resident will fill the clinical pathway form before the stroke inpatients were discharged. we also analyzed the data of clinical pathway every three months. according to the current data of stroke clinical pathway included demographic data, length of hospitalization days, complications, functional independent measure, brunnstrom motor recovery stage, mini-mental state examination, geriatric depression scale, blood pressure data, and post-stroke checklist for a retrospective analysis to provide more complete and more comprehensive information on follow-up care for stroke patients and effective use of medical resources, to improve the quality of future medical care and quality of life for stroke patients.


Eligibility criteria:
inclusion criteria: 1. ischemic and hemorrhagic stroke patients 2. mri confirmed the diagnosis of stroke 3. within three months of onset of unilateral limb hemiplegia in patients exclusion criteria: 1. initial tracheostomy impantation and hospital stay is less than 5 days 2. combined with other neurological diseases, such as epilepsy, multiple neuropathy, meniere's disease, vestibular neuritis, parkinson's disease, dementia or cerebellar atrophy, etc. 3. significant lesions of the lower limb joints, including joint contractures, lower limb fractures, joint replacement or long-term pain in patients with osteoarthritis 4. unstable signs of life (if not through the tilt bed test) or severe cardiopulmonary disease 5. those who can not cooperate with the study or who have not signed the inform consent

Keywords: stroke, clinical pathway, medical care
physical activity and insulin sensitivity dynamics

Conditions: Insulin Sensitivity

Summary: the study investigates the role of one single bout of exercise in mediating enhancement of muscle insulin sensitivity following a single bout of exercise. furthermore, the study is aiming to elucidate the temporal development in insulin signaling, at the early timepoints of insulin stimulation that may be responsible for the enhanced muscle insulin sensitivity. this will be investigated in young healthy males subjected to a one-legged knee-extensor exercise followed by a hyperinsulinemic-euglycemic clamp, a setup known to enhance muscle insulin sensitivity.

the participant arrives fasting at 8:00 am, having abstained from alcohol, nicotine, and caffeine for the past 24 hours and refrained from strenuous physical activity for the past 48 hours. the participants are then subjected to a one-legged knee extension exercise performed by the participant from 9:00 am to 10:00 am. groin catheters are inserted into the femoral artery and vein using ultrasound guidance and sterile technique two hours after the completion of the exercise, a catheter is inserted into an arm vein (antecubital vein) and groin catheters are inserted into the femoral artery and vein using ultrasound guidance and sterile technique. four hours after the exercise ends, a hyperinsulinemic-euglycemic clamp is commenced. the clamp begins with a bolus injection of insulin, followed by a continuous infusion. glucose is infused concurrently to maintain constant blood glucose levels. throughout the procedure, blood samples are collected every 5 minutes from the femoral catheters, and blood flow is measured using ultrasound doppler. muscle biopsies from the vastus lateralis of both legs are taken before the clamp starts and at 3, 6, 10, and 20 minutes after the clamp's initiation. following the 20-minute mark, the clamp continues until steady-state is achieved to determine tissue-specific and whole-body insulin sensitivity. over the course of the experiment, a total of 10 muscle biopsies and approximately 150 ml of blood are collected. the experimental part of the study is expected to conclude by 4:30 pm. participants are provided with food and beverages and observed for 1 hour before being allowed to leave the research laboratory.

Eligibility criteria:
inclusion criteria: * healthy individuals (no known diseases) * no use of medication * non-smokers * male * aged 22-35 years * fitness level (vo2max, i.e., maximal oxygen uptake) between 30-50 ml o2/min/kg * bmi between 28 and 35 exclusion criteria: * women * failure to meet all inclusion criteria * physical activity level (e.g., running, cycling, fitness, etc.) exceeding 6 hours per week * acute illness within 2 weeks prior to the study days * use of recreational drugs within 2 weeks prior to the study days

Keywords: exercise muscle insulin sensitivity muscle glucose uptake glut4 phosphoproteomics