Kornimate/medical-research-clean huggingface dataset:
intraoperative nirs of transplanted kidney for prediction of acute and sub-acute injury

Conditions: Graft Failure

Summary: this is a prospective, observational cohort study, designed to explore the use of nirs in kidney transplants. this study will investigate an association between measurements of intra- operative nirs and post - operative graft dysfunction as manifested in initiation of renal replacement therapy.


Eligibility criteria:
inclusion criteria: * kidney transplant candidates (living/ cadaver donor) at tlvmc who will consent to participate. exclusion criteria: * patients unable to give consent, * patients whose surgeries were aborted before transplant, * patients who were lost to follow up during the first 7 post-transplant days, * patients who suffered from surgical graft failure (vascular problems or need for re exploration due to bleeding etc.) * no pregnant patients will participate in this study. * no minors will participate in this study.
the effect of low-i̇ntensity combined exercises in patients with early stage als.

Conditions: Amyotrophic Lateral Sclerosis

Summary: the aim of this study is to investigate the effects of low-intensity combined exercises on balance, fatigue and quality of life applied to patients with als.

balance problems and signs of fatigue are seen in early-stage als patients. while balance problems lead to falls in als patients, fatigue also affects a part of their lives. studies investigating the effects of low-intensity exercise on fatigue, balance, and quality of life in patients with early-stage als are rare. this study will investigate the effects of low-intensity combined exercises on balance, fatigue and quality of life in patients with als. participants will be randomly divided into supervised and home groups. low-intensity exercises will be applied to the home exercise group as a home program for 1 hour a day, 3 days a week, for 6 weeks. low-intensity exercises will be applied to the supervised exercise group for 1 hour a day, 3 days a week for 6 weeks, accompanied by a physiotherapist. evaluations will be made at the beginning and at the end of the treatment. berg balance scale, fatigue severity scale (fss), amyotrophic lateral sclerosis assessment questionnaire-40 (alsaq-40) and revised amyotrophic lateral sclerosis functional rating scale (alsfrs-r) will be used to evaluate patients before and 6 weeks after treatment.

Eligibility criteria:
inclusion criteria: * being diagnosed with early-stage als by a neurologist * disease duration in the range of 1-18 months * alsfrs-r score \> 24 higher * without infectious disease * saturation \>95 * heart rate \<92 exclusion criteria: * history of other neurological disease * inability to walk * with mechanical ventilation * people with heart and respiratory insufficiency * people with neuropsychological or cognitive impairment * dyspnea after als

Keywords: amyotrophic lateral sclerosis balance fatigue quality of life
improving medication self-administration and health after brain injury

Conditions: Stroke; Stroke, Acute; Cognitive Impairment; Brain Injuries, Traumatic; Medication Adherence; Medication Compliance

Summary: the purpose of this research study is to assess medication self-administration (msa) and the impact of three different interventions on improving medication adherence. the findings for this study may help develop evidence-based reminder protocols to reduce medication self-administration errors after brain injury.

the investigators are interested in studying how brain injury (tbi, stroke, etc.) survivors manage self-administering their medication once they return home, and are aiming to improve their medication adherence. in this six month long study, patients will be placed into one of three intervention groups 1) standard care received (usual care, no reminder provided), 2) receive a video call at time medication is to be taken, 3) receive an automated text message when medication is to be taken. the investigators aim to identify which intervention is best at helping brain injury survivors adhere to their medication schedule, with the future goal of implementing this type of reminder protocol into standard care. hypothesis: the investigators hypothesize that automated reminder text messages will result in msa improvement comparable to video calls, maintained over the six month period. allocation to groups: patients will be randomized to receive video calls, automated text messages, or no intervention (standard care). the randomization schedule is by computer-generated number list.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 * less than three months post brain injury event * english speaking (learned english at age 10 or younger, and use it daily) * currently taking up to eight medications on a daily basis exclusion criteria: * legally blind * unable to give informed consent due to comprehension deficits * severe memory or cognitive impairments that would not allow for formal testing, as determined by the investigator * history of psychiatric hospitalization for attempted overdose of pills
effect of aging on micro-tensile bond strength and color stability of self-adhesive resin composite

Conditions: Tooth Decay

Summary: the objective of this study is to evaluate the micro-tensile bond strength of a newly self-adhesive resinous restorative material to dentin with and without application of universal bonding system (in-vitro) and to examine it's clinical performance by evaluation of it's color stability and marginal discoloration through a randomized clinical trial (in-vivo).

for color stability and marginal discoloration test, twenty class i cavities were prepared in the molar teeth of twenty different patients and then were randomly divided into two groups of ten patients each, where half of the molars was restored with surefil one self-adhesive bulk-fill composite and the other half with filtek one bulk-fill composite. a vita easyshade spectrophotometer was used to measure the baseline color of the restoration and at the margin after 24 hours and degree of color change and marginal discoloration after 3 months and 6 months of composite placement and then degree of color change (δe) was determined using the cie l\*a\*b\* system. all discolored restored molar teeth of both composite types were polished using a series of different thickness of sof-lex aluminum oxide discs (coarse, medium, fine), then the degree of color change of the restoration and at the margin (δe) was determined and was then compared to the baseline color measurements.

Eligibility criteria:
inclusion criteria: * patients with class i lesion in their maxillary or mandibular molars with a maximum of approximately 2 mm final cavity depth. * patients with teeth shade a2 according to vitapan classical shade guide. * patients with an acceptable oral hygiene level. * patients keen to regularly attend the follow up visits. exclusion criteria: * patients with heavy bruxism or traumatic occlusion. * patients with poor oral hygiene or active periodontal disease. * patients with exposed or endodontically treated teeth. * patients participated in a clinical trial within 6 months before beginning of this trial. * patients who decline to be involved in the study or sign the written consent. * patients unable to return for the follow up visits.

Keywords: color stability aging self-adhesive
no-reflow in patients with stemi after intracoronary tirofiban after opening of the track

Conditions: No-Reflow; STEMI; Intracoronary; Tirofiban

Summary: this study aims to assess the no-reflow in patients with stemi after intracoronary glycoprotein iib/iiia inhibitors after opening of track in thrombus.

st-segment-elevation myocardial infarction (stemi) is most commonly caused by rupture or erosion of an atherosclerotic plaque, resulting in acute occlusion of the coronary artery, and the preferred reperfusion strategy is primary percutaneous coronary intervention (pci). the no-reflow phenomenon is one of the most common causes of adverse cardiovascular events in patients stemi. in recent years, mechanical or pharmacological treatment strategies including adjunctive administration of glycoprotein iib/iiia inhibitors (gpi) have been proposed in patients with stemi.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old. * both sexes. * patients with stemi. st-segment elevated myocardial infarction is defined as typical chest pain \>30 minutes with st-segment elevation of \>1 mm in at least 2 consecutive leads on the electrocardiogram or new-onset left bundle brunch block. exclusion criteria: * treatment with thrombolytic drugs in the previous 24 hours. * known malignancy. * thrombocytopenia. * end-stage liver disease. * cardiogenic shock. * renal failure with glomerular filtration\<30 ml/min. * contraindication for the use of tirofiban.
effects of vocational rehabilitation group intervention on motivation and occupational self-awareness in individuals with intellectual disabilities

Conditions: Intellectual Disability

Summary: this study is an intervention study that investigates the effects of a group-based approach to motivation and occupational self-awareness of individuals with intellectual disability (id). the intervention method was developed by following the intervention mapping method. an 8 weeks group intervention (twice a week) was applied to individuals with id which includes; introduction to intervention and meeting with other group members self-awareness training occupational self-awareness taking responsibility group work and labor division problem identification problem-solving the entire program was structured and guided by the prepared manual (available upon request from the authors). the manual was prepared by the authors of this study to ensure consistency between different sessions and groups. all sessions were diffusively explained in the manual as well as the individual session booklets. the supervisors were able to follow the structure of the sessions from those booklets. additionally, there were visual materials for each session as in; presentations, graphics, and photographs. the program supervisors (therapists) met once every week to discuss the progress, participation, and overall status of each participant. homework assignments were utilized to facilitate learning. families were not included directly in the group sessions, however were informed about the homework assignments. homework assignments consisted of very basic mental practice and reenactment regarding the session's topic and concepts. families were also included in the final week's sessions since graduation certificates were handed out during these sessions and also small celebrations were carried out.


Eligibility criteria:
inclusion criteria: 1. being between the ages of 18 and 65, 2. not being currently working, 3. having formal intellectual disability diagnosis, 4. having scored 23 points or less from the mini mental state examination, 5. being able to understand basic turkish language and 6) volunteering to participate in the study exclusion criteria: 1. having severe communication problems specifically in self-expression, 2. not being able to continue participating in the study for the projected study duration, 3. not permitted to participate by legal guardian.

Keywords: self awareness occupational therapy vocational rehabilitation intellectual disability motivation
effect of the hands- on mckenzie program on low back pain

Conditions: Low Back Pain

Summary: low back pain (lbp) is one of most prevalent types of musculoskeletal pain and is strongly related to disability. the mckenzie method is one of most popular treatment options for lbp. the objectives of this study are to determine the effect of the hands-on mckenzie program on pain, disability, spine mobility, and posture deviations in subjects with derangement low back pain.

thirty eight patients with sub-acute and chronic lbp will be randomly assigned to the mckenzie group (mg) or the control group (cg). the mg will perform exercises with the hands-on procedure (three sessions per week) for two weeks, while the cg will perform only exercises for two weeks. both groups will do a home exercise program. the outcome assessments will measure pain by the pain numerical rating scale (nprs), the level of disability through the oswestry disability index (odi), spine mobility by range of motion (rom) for the lumbar spine, and the centralization of symptoms and the postural alternation by postural analysis grid (pag). by using spss version 20, a paired t-test will be use to study the effect of the mckenzie program before and after treatment. an independent t-test will be used to study the significance between the two groups.

Eligibility criteria:
inclusion criteria: - the patients will be age from 18 to 60 years old, and have lbp with or without leg pain, lasting from seven weeks to 12 weeks or more. additional criteria include recurrent lbp, demonstrating a dp during the mechanical assessment , the subjects have a bmi of normal (17 to 23.9) or overweight (24 to 28.9). patient is eligible. exclusion criteria: participants who are underweight (bmi \< 18.5) or obese (bmi ≥ 30) will be excluded . those with contraindications to physical exercise according to the guidelines of the american college of sports medicine , such as those with serious spinal pathologies (fractures, tumours, and inflammatory diseases, such as ankylosing spondylitis), nerve root compromise (e.g., cauda equine syndrome), severe cardiopulmonary diseases,scd, or pregnancy will be excluded. -
a pharmacokinetic study to determine the oral bioavailability of methotrexate in patients with inflammatory bowel disease

Conditions: Inflammatory Bowel Disease

Summary: patients with inflammatory bowel disease (ibd) who require methotrexate (mtx)for treatment currently receive this drug by injection. mtx is also available as a pill that can be given by mouth but it is not known how well the drug enters the body in patients with crohn's disease or ulcerative colitis. this study is being done to compare how much mtx enters the body when the drug is taken by mouth compared to when it is given by injection. if the drug is well absorbed, it may allow patients to receive the drug by mouth.


Eligibility criteria:
* adult or pediatric patients with ibd (cd or uc) currently receiving mtx as part of their clinical care. * patients must be receiving weekly mtx at a dose between 7.5 and 40 mg/m2. * weight \>= 12 kg. * normal serum creatinine.
comparative effectiveness of intervention in multi-level hospitals for acute traumatic brain injury(metric-tbi)

Conditions: Traumatic Brain Injury

Summary: a prospective, multicenter, observational cohort study is designed to compare the effectiveness of intervention in multi-grade hospitals for acute traumatic brain injury and to optimize clinical outcomes.

traumatic brain injury (tbi) is associated with significant morbidity, mortality, and disability, profoundly impacting public health. this study aims to establish a database for acute craniocerebral trauma within the beijing-tianjin-hebei region, and compiles indicators of hospital treatment capabilities and patient data, including neuroimaging, clinical progression, and rehabilitation prognoses.the study is bifurcated into two segments: the initial phase surveys the current status of acute treatment outcomes for tbi inpatients across hospitals in the beijing-tianjin-hebei region and conducts a comparative effectiveness analysis to identify the clinical interventions to optimize. subsequent phases build on the former by applying optimized treatment strategies to improve efficacy and establish collaborative optimized treatment protocols. this is a prospective, multicenter, observational study designed to enroll 2,000 patients under the age of 90 years with traumatic brain injury in the presence of clinical symptoms confirmed by computed tomography or magnetic resonance imaging.the primary outcome is the extended glasgow outcome score within 12 months. secondary outcomes include the generalized anxiety disorder-7 (gad-7), patient health questionnaire-9(phq-9), rivermead post-concussion symptoms questionnaire(rpq), ptsd checklist-5 version(pcl-5)，six-item screener (sis) and 12-item short-form health survey version 2(sf-12v2). the objective of this study is anticipated to the beijing-tianjin-hebei region a 20 percent increase in the number of cases treated by optimized clinical practice guidelines and a 10 percent decrement in mortality and disability rates among tbi patients in the region.

Eligibility criteria:
inclusion criteria: * patient (1 years to 89 years) presenting with clinical symptoms of traumatic brain injury * traumatic brain injury verified on cranial computed tomography or magnetic resonance imaging * written informed consent from patients or their next of kin according to the patient's cognitive status exclusion criteria: * patients ≥90 years of age * patients who did not accept follow-up visits or were unable to complete follow-up assessments * patients with incomplete information * patients who did not obtain written informed consent * patients with concomitant cancer or other serious illnesses

Keywords: traumatic brain injury beijing-tianjin-hebei region database comparative effectiveness of intervention clinical treatment guideline
end-on versus parallel radiofrequency lesioning for neurotomy of the cervical medial branch nerves

Conditions: Neck Pain; Zygapophyseal Joint Arthritis

Summary: aim of the endparl study is to compare the efficacy and effectiveness of the two techniques utilizing sharp straight conventional radiofrequency needle with a trident needle for radiofrequency neurotomy of cervical medial branch nerves (cmbns), in patients presenting with chronic, moderate-to-severe, neck pain due to cervical zygapophyseal joint osteoarthritis, as diagnosed by positive responses to two consecutive diagnostic blocks with local anesthetic of the cmbn.


Eligibility criteria:
inclusion criteria: 1. adult patient of either gender aged 18-85 years 2. predominant axial (non-radicular) neck pain for at least 3 months 3. 7-day average nrs score for neck pain ≥ 5/10 at baseline evaluation 4. moderate or greater functional impairment due to pain, defined as ndi questionnaire raw score of 15 out of 50 (≥30% )e failure to respond to conservative medical management (pharmacologic, physical therapy) for at least 3 months; f) positive response to two consecutive diagnostic blocks of the cmbn with a short and long-acting anesthetic exclusion criteria: 1. participants with financial incentives or litigation associated with ongoing pain 2. inability to complete assessment instruments 3. chronic widespread pain 4. prior rfn of the cmbn; 5. severe mental health issues 6. pregnancy or other reason that precludes the use of fluoroscopy 7. untreated coagulopathy 8. systemic or local infection at the time of screening.

Keywords: radiofrequency neurotomy cervical medial branch nerves
study of risk factors and clinical characterization of rapidly growing melanoma

Conditions: Melanoma Cancer

Summary: state of the question over the past decade, the incidence of melanoma (mm) has steadily increased in france and in most developed countries. this increased incidence was concerned mainly mm thin while the incidence of mm thick that represent the true "killers", and mortality from mm remained stable or increased slightly over the same period. these epidemiological data and observations from everyday medical practice dermatologists suggest the existence of different growth patterns within mm. indeed, some mm progressing slowly sometimes for decades before diagnosis but are thin at the time of resection. conversely, others mm grow very quickly, resulting in thick tumors despite a diagnosis and resection sometimes very early. these fast growing mm (fgmm) probably contribute significantly to the relative mortality in mm, as improved screening failed to influence to this day. our team has already demonstrated that the growth kinetics of the mm was a prognostic factor of tumor aggressiveness regardless of the thickness of the tumor. using the same method to calculate the growth rate, an australian team recently studied the growth rate in a population of patients suffering from mm. in this population 1/3 of mm had a growth of more than 0.5 mm per month. clinical aspects and fgmm of these risk factors were individuals (injuries symmetrical achromic and regular occurrence among about older and low-nevi). the european and australian people are very different in particular regarding the prevention policy, these results can not be extrapolated to the french population.the main objective is to identify risk factors for fgmm in french propulation


Eligibility criteria:
inclusion criteria: * patient with breslow primitive melanoma for over 1 mm skin affected exclusion criteria: * patient unable to answer questionnair concerning its melanoma history desease
detection of meconium in amniotic fluid in post term pregnancies

Conditions: Meconium

Summary: meconium constitutes the bowel contents of the fetus and is normally expelled only after birth. however, it may be secreted into the amniotic fluid of 20% of all fetuses. meconium stained amniotic fluid had been recognized from ancient times as an obstetric hazard which complicates delivery and is associated with increased newborn morbidity and mortality. at present there is no viable diagnostic test for meconium prior to the onset of labor and the rupture of membranes. the system developed for the detection of meconium, based on recognizing a characteristic fluoroscopic spectral pattern emitted by meconium under light excitation at a specific wavelength. the diagnostic test being developed does not require penetration into the amniotic sac and is safe, painless and simple to perform.


Eligibility criteria:
inclusion criteria: * 37-42 weeks regnancy without rupture of membranes exclusion criteria: * none

Keywords: amniotic fluid post term pregnancies