Kornimate/medical-research-clean huggingface dataset:
mobile intervention for suicidal thoughts

Conditions: Suicide

Summary: one of the factors that contributes to suicide risk is what is known as a "suicidal belief system." this belief system is made up of several cognitions that been associated with suicide risk among military personnel. modification of these cognitions may reduce suicidal thoughts and behaviors. the study team has developed a brief mobile intervention entitled the mobile intervention for suicidal thoughts (mist) that uses evidence-based interpretation bias modification techniques to reduce these suicide cognitions. the goal of this project is to is to conduct a pilot trial of the mist intervention to evaluate whether it is feasible an acceptable as an adjunct treatment for veterans with suicidal ideation.

one of the factors that contributes to suicide risk is what is known as a "suicidal belief system." this belief system is made up of several cognitions, including hopelessness, thwarted belongingness, perceived burdensomeness, unlovability, unbearability, and unsolvability. these cognitions have all been associated with suicide risk among military personnel. modification of these cognitions may reduce suicidal thoughts and behaviors. the study team has developed a brief mobile intervention entitled the mobile intervention for suicidal thoughts (mist) that uses evidence-based interpretation bias modification techniques to reduce these suicide cognitions. the goal of this project is to is to conduct a pilot trial of the mist intervention to evaluate whether it is feasible an acceptable as an adjunct treatment for veterans with suicidal ideation. the investigators will conduct a pilot randomized controlled trial (rct), in which 50 veterans with suicidal ideation will be randomized to either mist plus treatment as usual and safety planning versus treatment as usual and safety planning. the central hypothesis is that veterans will find mist acceptable and will be willing to use it to reduce their suicidal thoughts.

Eligibility criteria:
inclusion criteria: * veterans using the durham va health care system * endorsing suicidal ideation without intent in the last 30 days, established via c-ssrs * meet at least every 4 months with a mental health provider, established via chart review chart * can read at least 6th grade level material, established by their demonstrated ability to read the consent form and answer basic questions about it exclusion criteria: * currently in a period of active psychosis or mania, established via the scid-5 * currently meeting criteria for a moderate or severe alcohol or substance use disorder, established via the scid-5 * endorsing suicidal intent, established via c-ssrs * exhibit current prominent suicidal or homicidal ideation requiring immediate intervention * have used the mist intervention before as part of another research study

Keywords: suicide suicide cognitions mobile intervention veterans
sperm pathology samples and morphokinetics

Conditions: Cylinical Embryo; Oligospermia

Summary: the embryo kinetics may be a new prognostic factor for choosing the embryos with the highest implantation potential. in order to identify the factors that may affect the rate of embryo cleavage, there are many studies about morphokinetics and culture medium, oxygen tension, oocyte quality or type of medication used for ovarian stimulation. however there are no published data with respect to the influence of semen quality in the embryo kinetic. in this study the investigators propose that the sperm quality may has influence in the embryo division.


Eligibility criteria:
inclusion criteria: * sperm samples with more than 15 mill/ml of sperms, more than 40% of mobile sperms * sperm samples with less than 5 mill/ml of sperms, less than 10% of mobile sperms exclusion criteria: * sperm samples between 5 to 15 mil/ml of sperms and between 10% to 40% of mobile sperms
study of improving insulin sensitivity by electroacupuncture therapy

Conditions: Diabetes Mellitus, Type 2; Insulin Resistance

Summary: the aim of this study is to find out whether the hypoglycemic and improving insulin resistance effect will appear or not, when ea applying on specific acupoints of niddm patients.

some previous animal model studies reveal that electroacupuncture (ea) applying on specific acupoints, such as zhongwan and zusanli acupoint, can reduce plasma glucose levels and encourage insulin secretion, even improve insulin resistance. in this study, we want to observe these results on type ii diabetic patients who have been diagnosed in five years under a study design of randomized control trial (rct) to obtain evidence on clinical. we undertook a randomized, single blind and sham group controlled study to evaluate the effect of ea with a frequency in 15 hz and fixed intensity (10 ma) on human zusanli acupoint. a total of 26 newly diagnostic type ii diabetic patients are enrolled in this study. they are randomly divided into 2 groups. there are 13 patients in the experimental group (eg) with ea treatment, and the other 13 patients are divided into control group (cg) with sham treatment. the main outcome is the changes of laboratory parameters between before and 30 minutes after the test.

Eligibility criteria:
inclusion criteria: * newly diagnosed niddm patient within 5 years * age between 30 to 65 years old * controlled bp below 140/90 mmhg * oral hypoglycemic agent (oha) therapy with gliclazide twice per day. exclusion criteria: * disorders of hemostasis * patient had received insulin therapy * severe disease such as cva, cad within 6 months * arrhythmia history and on pacemaker.

Keywords: electroacupuncture, plasma glucose, plasma insulin
antazoline in rapid cardioversion of paroxysmal atrial fibrillation

Conditions: Paroxysmal Atrial Fibrillation

Summary: the purpose of this randomized, double blind, placebo-controlled, superiority clinical trial was to assess clinical efficacy of antazoline in rapid conversion of atrial fibrillation during observation sinus rhythm.

antazoline is a first generation antihistaminic agent with chinidin-like properties. when administered intravenously, antazoline exerts a strong antiarrhythmic effect on supraventricular arrhythmia especially on atrial fibrillation (af) facilitating rapid conversion to sinus rhythm. despite relative lack of published data antazoline is marketed in poland and widely used in cardiology wards and emergency rooms due to its efficacy, safety and rapid onset of action within minutes of administration. to show superiority of antazoline over placebo a sample size of 80 patients was calculated based on following assumptions: two-tailed test, a type i error of 0.01, a power of 90%, efficacy of placebo 5%, efficacy of antazoline 50% and 20% drop-out rate to fulfill the criteria of intention-to-treat analysis. due to presumed lack of statistical power the secondary end points and safety endpoints will be considered exploratory.

Eligibility criteria:
inclusion criteria: * written informed consent for participating in the study and written standard version of informed consent for cardioversion accepted in institute of cardiology, warsaw, poland * age above 18 and good general condition * potassium level over 3.5 mmol/l * stable cardio-pulmonary state on enrollment * in case of unclear history of heart failure or suspicion of impaired left ventricle function echocardiography is indicated prior to enrollment * a long-term antiarrhythmic drug therapy is allowed exclusion criteria: * lack of written informed consent * antazoline allergy * af related to significant valvular disease * clinically significant heart failure or ejection fraction \< 55% * diastolic blood pressure (bp) \< 100mmhg * history of significant bradyarrhythmia not treated with permanent pacemaker * qt prolongation over 440ms or qtc (bazett's formula) over population norm * tachycardia \> 160' * advanced liver or kidney failure * acute coronary syndrome, coronary artery by-pass graft, stroke or transient ischemic attack within 30 days before enrollment * preexcitation in ecg not treated by radiofrequency ablation of accessory pathway * signs and symptoms of ischemia related to af * an investigational drug used within 30 days before enrollment * pregnancy or breast feeding

Keywords: atrial fibrillation paroxysmal cardioversion antazoline
academic stress and proinflammatory cytokines: omega-3 intervention

Conditions: Stress-related Changes in Inflammation

Summary: this study is designed to examine the effects of fish oil on immune function and mood in medical students.

this study will examine how supplementation with omega-3 polyunsaturated fatty acids (key fish oil components) affects immune and mood responses to examination stress. this study will examine these outcomes in medical students during academic examination periods as well as less stressful non-exam periods. participants will take fish oil supplements or placebo pills for approximately 3 months during which time relevant mood, endocrine, and immune measures will be assessed. for detailed information about the study, please visit our website at http://www.stressandhealth.org

Eligibility criteria:
inclusion criteria: * osu preclinical medical or dental student, or graduate nursing student * male or female exclusion criteria: * taking certain medications with immune or endocrine effects * chronic health conditions * smoking * excessive use of alcohol or caffeine * significant digestive problems * routine use of fish oil or flaxseed supplements or high fish intake * fish allergy

Keywords: affect inflammation
effectiveness of whatsapp (a messenger program) usage in emergency department (ed)

Conditions: Communication

Summary: effective communication between consulting physicians and the emergency physicians is critical for patients in the emergency department. the aim of this study was to determinate effectiveness of whatsapp usage for communication between physicians.

effective communication between consulting physicians and the emergency physicians is critical for patients in the emergency department. many hospitals still use outdated pager systems as the foundation for clinical communication between physicians and other health care professionals. but, outdated pager systems contain some problems including long waiting-times for the return of a page, high costs, frequent interruptions, and the inability to identify the location or identity of the caller. this outdated communication technologies in healthcare can place patient safety at risk. therefore they are no longer seen as an effective communication tool given the obvious advantages of smart phones. whatsapp messenger, which is a messaging program for smart phones, is the most commonly used for communication in at present. as of september 2015, whatsapp incorporated announced more than 900 million users. this is making it the most globally popular messaging application. whatsapp messenger have been started to be used for communication in healthcare. so, this study aims to trial the effect of whatsapp usage for communication between physicians. study design and setting: a prospective, randomized, double-blind, controlled, single-center, clinical trial was conducted in ed of a tertiary care university hospital with an annual census of approximately 200,000 visits.

Eligibility criteria:
inclusion criteria: 1. adult patients who performed consultation in emergency department. 2. patients who are consulted to a physician using whatsapp on a regular basis and who is chosen by an assistant blinded to the study. exclusion criteria: 1. patients below 18 years of age 2. missing emergency service consultations 3. patients with more than one consultation call 4. consultations which do not determined the arrival duration to emergency service

Keywords: referral and consultation emergency department whatsapp
"sandwich" chemotherapy with radiotherapy in newly diagnosed, stage ie to iie, enktl

Conditions: Treatment Refusal

Summary: a phase 2 study was conducted of "sandwich" protocols, with earlier rt after an initial 2 of p-chop (pegaspargase, cyclophosphamide,vincristine, doxorubicin and dexamethasone ), followed by further two "consolidation" cycles,to explore the appropriate mode of combined modality therapy (cmt) in early stage enktl.

the extranodal natural killer/t-cell lymphoma (enktl) shows high local or systemic failure rates when radiotherapy (rt) is taken as the primary treatment, suggesting a role for chemotherapy (ct) added to rt for this disease. however, the appropriate mode of combined modality therapy (cmt) has not been fully defined.we conducted a prospective phase ii study of "sandwich" pegaspargase, cyclophosphamide,vincristine, doxorubicin and dexamethasone (p-chop) regimen in combination with radiotherapy.the "sandwich" protocols, refer to earlier rt after an initial 2 cycles of p-chop followed by further two "consolidation" cycles.

Eligibility criteria:
inclusion criteria: * newly diagnosed enktl * age:18-69years * ann arbor stage ie,or stage iie with cervical lymph node involvement * at lease one measurable lesion * receive no chemotherapy or radiotherapy before * eastern cooperativeoncology group performance status of 0 to 2. * adequate hematologic function (eg, white blood cell ≥ 3×10e9/l,neutrophils count ≥1.5×10e9/l, and platelet count≥ 100×10e9/l),renal function (eg, serum creatinine≤1.5 mg/dl and creatinine clearance ≥50 ml minute), and hepatic function (e.g, total bilirubin≤ 2 times the upper limit of normal and aspartate and alanine transaminase levels ≤ 3 times the upper limit of normal) exclusion criteria: * mismatch the inclusion criteria * systematic central nervous system involvement * previous or concomitant malignancies and any coexisting medical problems that could cause poor compliance with the study protocol. * primary lesion not from the upper respiratory

Keywords: extranodal natural killer/t-cell lymphoma nasal type radiotherapy chemotherapy
diet for colonoscopy preparation in diabetic patients

Conditions: Diabetes Mellitus; Colonic Diseases

Summary: this trial will compare the efficacy of to 2 different sets of dietary recommendations to be followed before colon cleansing for colonoscopy in diabetic patients.

consecutive diabetic patients undergoing an ambulatory colonoscopy at the participating sites will be randomized to follow one of two different sets of dietary recommendations. the experimental group will be asked to start a low-residue diet 4 days before the procedure, during which the therapy for diabetes will be adjusted. the control group will be asked to follow a low-residue diet for 3 days followed by a liquid diet during the day before the procedure, and no adjustments will be made to their usual treatment. colon cleansing will be undertaken with polyethylene glycol (4 liters in the usual split administration scheme) in both groups. analogic visual scales and standardized questionnaires on various aspects that may influence the degree of satisfaction about the preparation will be answered by the participants and collected before the colonoscopy. the endoscopist, blinded to the preparation method, will grade the adequacy of the preparation. adverse events will be recorded up to 1 month after the procedure

Eligibility criteria:
inclusion criteria: * patients scheduled for a diagnostic, screening or follow-up outpatient colonoscopy * diabetes mellitus (being treated with insulin or any oral agent). exclusion criteria: * unwillingness to participate. * hospital admission at the time of colonoscopy. * inability to follow instructions * active inflammatory bowel disease * previous colectomy. * incomplete colonoscopies due to technical reasons or contraindication for the procedure as evaluated by the endoscopist

Keywords: colonoscopy diabetes mellitus diet polyethylene glycols efficacy personal satisfaction
postoperative outcomes and patient satisfaction with mayo clinic florida care hotel after mastectomy and tissue expander placement

Conditions: Breast Carcinoma

Summary: this study evaluates the postoperative outcomes of patients who are admitted to the mayo clinic florida care hotel after mastectomy and tissue expander placement. at mayo clinic florida, patients receiving low risk surgeries are often admitted to the hospital overnight for observation. a new model of delivering patient care was created at the mayo clinic florida coined the "care hotel." this is a temporal, voluntary accommodation that offers patients a comfortable environment to receive nursing care before or after hospital treatment with in-person daytime monitoring and 24-hour virtual tele-monitoring in a hotel setting. this study evaluates post operative complications in patients who underwent mastectomy followed by tissue expander reconstruction and were admitted to the care hotel for overnight observation compared to the standard hospital admission and those who are discharged home.

primary objective: i. to investigate post operative complications in patients who underwent mastectomy followed by tissue expander reconstruction and were admitted to the care hotel for overnight observation compared to the standard hospital admission and those who are discharged home. outline: this is an observational study. patients have their medical records reviewed and may complete a survey on study.

Eligibility criteria:
inclusion criteria: * women who underwent mastectomy followed by tissue expander reconstruction for breast cancer or high-risk gene mutation prophylaxis followed by immediate tissue expander reconstruction who are either admitted to the care hotel post operatively, discharge home or admitted to the hospital. exclusion criteria: * younger than 18 years old.
the serum tissue factor level in lung cancer patients as a prognostic factor

Conditions: Lung Cancer

Summary: this study uses serum tissue factor and tissue factor inhibitor and factor vii to monitor the pre-coagulation status in lung cancer patients and to correlate the pre-coagulation status with clinical staging and prognosis.

the staging of lung cancer was according to tumor size, involvement of lymph node and metastatic status. but there is a different prognosis in cancer patients of the same stage. the coagulation status of cancer patients was considered as an important possible prognostic factor. so in this study, we want to evaluate patients' coagulation status and find the relation of coagulation status and cancer status. we thus propose a prospective study using coagulation factors in order to search for the relationship between cancer stage and pre-coagulation status in taiwanese lung cancer patients. we will also evaluate the potential use of tissue factor as a prognosis predictor in lung cancer patients.

Eligibility criteria:
inclusion criteria: * patients with newly-diagnosed lung cancer * serum from cancer-free healthy volunteers exclusion criteria: * chronic renal failure or end-stage renal disease \[esrd\] (creatinine \[cr\] \> 2 ) * hyperlipidemia on statin therapy * acute myocardial infarction * tapal or plavix use * active thromboembolic event * severe liver disease (\> child b)

Keywords: tissue factor lung cancer tissue factor protein inhibitor factor vii factor x
an observational study to evaluate the clinical utility of the oncomine precision assay within the exactis network

Conditions: NSCLC

Summary: a multi-centre observational study to evaluate the clinical utility of returning genomic aberration results using the oncomine precision assay in advanced or metastatic non-small cell lung cancer patients within the exactis network

this prospective multi-center observational study will evaluate the clinical utility of returning genomic aberration results in blood and/or tissue using the oncomine precision assay in non-small cell lung cancer (nsclc) patients. up to 100 patients with stage iiib/iv nsclc will consent to have their blood and tissue profiled on the oncomine precision assay. a baseline plasma sample will be collected for all patients, of which up to 50 patients will have a tissue sample collected from pathology archives or planned biopsy or surgery.

Eligibility criteria:
inclusion criteria: * patients with nsclc, which is (i) advanced or metastatic (stage iiib/iv), (ii) non- squamous histology nsclc as confirmed by local histopathology (mixed squamous and adenocarcinoma is allowed), and has (iii) radiographically measurable disease with at least one bidimensionally measurable lesion of \> 1 cm by ct scan * no prior treatment for advanced or metastatic nsclc, except for palliative radiation therapy to non-lung or non-thorax metastases. patients who received palliative radiation therapy to metastases located within or approximately to the lung or thorax must be evaluated for eligibility. * willing and able to provide adequate blood sample prior to starting treatment. * willing to provide primary or metastatic tissue, if available. * signed and dated research ethics board (reb)-approved informed consent form for exactis-01 or pmt. * not pregnant or breastfeeding exclusion criteria: • patients who have a history of another active cancer within the past 2 years from date of consent except cervical cancer in situ, basal cell carcinoma of the skin or another in situ carcinoma that is considered cured by the investigator.

Keywords: genomic aberrations exactis network advanced or metastatic non-small cell lung cancer liquid biopsy
comparison of expandable and fixed size cryoballoon for the treatment of paroxysmal atrial fibrillation

Conditions: Atrial Fibrillation

Summary: the goal of this clinical trial is to compare two different, market approved, cryoballoon devices for the treatment of paroxysmal atrial fibrillation (af). the main aims of the study are: * to compare the efficacy of two ablation devices (acute and 1 year success rates) * to compare the procedural characteristics (procedure duration, fluoroscopy duration, ablation time * to compare the complication rates participants who have indication for cryoballoon ablation of af will be randomized in 1:1 fashion to older fixed size cryoballoon and newer expandable cryoballoon. standard of care cryoballoon procedure will be performed alongside with standard postprocedural follow-up. • to compare the complication rates participants who have indication for cryoballoon ablation of af will be randomized in 1:1 fashion to older fixed size cryoballoon and newer expandable cryoballoon.

patients suffering from paroxysmal atrial fibrillation who are scheduled (independently of this study) for cryoballoon pulmonary vein isolation will be informed about the study and potential risks. all patients who give written informed consent will be randomized to 4th generation artic front advance pro device (fixed size balloon of 28 mm) and polar x fit device (28-31 mm expandable balloon). the ablation procedure will be performed in standard of care fashion. also, standard postprocedural follow up of the patients will be scheduled with outpatient clinic visits and 24-hour holters and 3, 6 and 12 months, and yearly thereafter. extra visits will be scheduled in the case of symptoms/palpitations. standard patient and procedural data will be collected alongside with the information obtained in the follow up.

Eligibility criteria:
inclusion criteria: * paroxysmal atrial fibrillation * patient scheduled for cryoballoon pulmonary vein isolation regardless of this study exclusion criteria: * unwilling to sing the informed consent left atrium size \> 55 mm uncontrolled heart failure (nyha iii-iv) intracardiac thrombi

Keywords: atrial fibrillation ablation cryoballoon