Kornimate/medical-research-clean huggingface dataset:
tajik migrant health education study

Conditions: HIV Infections; Hepatitis C; Risky Health Behavior; Risk Reduction Behavior

Summary: this study will test the efficacy of a peer-education prevention intervention to reduce risky drug, alcohol, and sexual behaviors among male tajik labor migrants who inject drugs (mwid) while working in moscow. the peer educator intervention will be compared to a health education control intervention. each intervention consists of 5 weekly 2-hour small group sessions. follow-up assessments will be conducted at 3, 6, 9, and 12 months after the intervention. it is hypothesized that, compared to mwid who receive the health education control intervention, those who receive the peer educator intervention will have a greater reduction in the frequency of risk behaviors. similar effects are expected for network members of intervention participants.

the investigators will recruit male tajik migrants who inject drugs from 12 different sites in moscow, including bazaars and other work sites. in both study arms, the recruited men (index participants) will be required to recruit two eligible mwid peers for interviews prior to being interviewed themselves. participants will be randomly assigned to either the peer educator intervention program or the health education intervention program. after peer-recruited network members are enrolled and interviewed, the index participant will participate in the peer educator training or the control group activities. all participants and recruited network members will then be followed and re-interviewed at 3-month intervals for one year to assess changes in risky drug, alcohol, and sexual behaviors due to intervention participation and through diffusion to network members. the investigators will also collect data from voluntary hiv and hcv testing conducted at 6 months (hcv only) and at 12 months (hiv and hcv) post-intervention.

Eligibility criteria:
inclusion criteria: * adult tajik man * injected drugs in past 30 days * living and working as migrant laborer in moscow exclusion criteria: * does not intend to stay in moscow for the next 12 months

Keywords: injection drug use migrant workers risk behavior
microstructural changes in the brain during recovery after mild traumatic brain injury

Conditions: Brain Concussion

Summary: this study examines the possible microstructural changes in the brain during recovery after mtbi using diffusion mri.

this study is embedded in a larger randomized controlled trial (rct) (clinicaltrials.gov id: nct02337101) from which the subjects are recruited and will separately examine the possible microstructural changes in the brain during recovery after mild traumatic brain injury (mtbi) in subjects with ongoing symptoms more than 2 month after mtbi in both groups from the rct. several biomarkers and brain areas has been investigated as possible sites of injury after mtbi. the nature of the diffuse chronic post-concussion symptoms (pcs) makes corpus callosum (cc), thalamus (tha) and hippocampus (hip) interesting because of their central position and connection to widespread motor, sensory and cognitive processes and other brain areas. in most prior studies conventional magnetic resonance imaging (mri) has failed to detect pathology especially in the chronic phase after mtbi. diffusional kurtosis imaging (dki) and diffusional tensor imaging (dti) are more sensitive to microstructural changes and might serve as biomarkers in the brain after mtbi. we hypothesized that a change in symptoms (as measured by cognitive performance and self reported symptoms) will correlate with a change in microstructural changes (as measured with dki) in thalamus, corpus callosum and hippocampus from baseline 2-6 month after mtbi to follow up 6 month after. separate correlations will also be made for both treatment and control group within the cohort.

Eligibility criteria:
inclusion criteria: * concussion caused by a head trauma according to the diagnostic criteria recommended by the danish consensus report on commotio cerebri within the last 2-6 months. the criteria are based on recommendations by the who task force, but with the amendment, that there must have been a direct contact between the head and an object in order to rule out pure acceleration - deceleration traumas. * age 18 to 30 years at the time of the head trauma. * able to understand, speak and read danish. * patients with symptoms on at least three items on the rivermead post concussion symptoms questionnaire (rpq) rated as moderate or severe problem. pcs have to be subjectively rated as causing substantial impairment in daily life. * suitable for mri examination exclusion criteria: * objective neurological findings from neurological examination and / or acute trauma ct scan, indicating other neurological diseases or brain damage. * previous concussion leading to persistent pcs within the last two years. * severe abuse of alcohol, prescription drugs and / or illegal drugs. * psychiatric morbidity or severe neurological disease that impedes participation in the treatment, i.e. bipolar disorder, autism, psychotic disorder (lifetime), multiple sclerosis etc.
to compare intravitreal clindamycin & dexamethasone with classic treatment of toxoplasmic retinochoroiditis

Conditions: Chorioretinitis

Summary: toxoplasmosis, an intra cellular parasite, is a very important cause of chorioretinitis. the goal of treatment is arresting multiplication of the parasite in its inflammatory active phase. in this study the investigators try to compare the efficacy of the classic regimen (pyrimethamine-sulfadiazine + prednisolon) with intravitreal clindamycin \& dexamethasone.


Eligibility criteria:
inclusion criteria: * patients with toxoplasmic chorioretinitis * location of the lesion within zone i of the retina or a lesion greater than 2dd with 3+-4+ vitreous inflammation in zone ii or iii * no allergic history to the used drugs * no any other diseases exclusion criteria: * any allergic reaction to the used medications * one eyed patients * partially treated patients

Keywords: toxoplasmosis chorioretinitis intravitreal clindamycin dexamethasone in chorioretinitis toxoplasmic
neoadjuvant chemotherapy with docetaxel and gemcitabine in locally advanced breast cancer

Conditions: Breast Cancer Stage II; Breast Cancer Stage III

Summary: the purpose of this study is to assess the response of docetaxel and gemcitabine in the neoadjuvant setting in women with locally advanced breast cancer.

neoadjuvant chemotherapy is now standard for patients with locally advanced breast cancer, and this method of treatment has been extended to patients with earlier disease without affecting the treatment outcome. this single arm, multicenter phase ii study was designed to evaluate the response rate, toxicity, progression free survival and tumor control rate of docetaxel and gemcitabine in the neoadjuvant setting with locally advanced breast cancer.

Eligibility criteria:
inclusion criteria: 1. women aged : 20\~70 years 2. world health organization (who) (eastern cooperative oncology group \[ecog\]) performance status 0-2 3. patients with measurable lesion assessed by imaging using the recist (response evaluation criteria in solid tumor) guideline 4. have given written informed consent and are available for prolonged follow-up exclusion criteria: 1. patients with previous chemotherapy for recurrent breast cancer 2. breast cancer recurrence within 12 months after taxane treatment 3. her-2/neu expression breast cancer 4. patients with malignancies (other than breast cancer) within the last 5 years, except for adequately treated in situ carcinoma of the cervix or basal cell, squamous cell carcinoma of the skin. 5. brain metastasis 6. uncontrolled infection, medically uncontrollable heart disease 7. other serious medical illness or prior malignancies 8. pregnant or lactating women were excluded.

Keywords: locally advanced breast cancer docetaxel gemcitabine
pre-operative assessment of chest wall invasion in nsclc using pre-operative, surgeon performed ultrasound

Conditions: Non Small Cell Lung Cancer

Summary: non-small cell lung cancer (75% of lung cancer) is associated with involvement of the parietal pleura and or chest wall (soft tissue and/or bone) in 5-8% of patients. invasion of the chest wall increases the t staging in the tumor, node, mestasis (tnm) classification system of lung cancer to a t3 and is associated with decreased survival and more extensive operative procedures. the reported 5-year survival for patients with t2 tumors is 58% compared to 38% in patients with t3 lesions. the american college of chest physician has still not identified the best tool to assess chest wall invasion by lung cancer, ct-scan being used by physicians for this assessment. in some studies, ct scan has been shown to have a sensitivity ranging from 42 % to 68 % in assessing chest wall invasion, and a specificity ranging from 66 % to 100 %. trans-thoracic ultrasound (us) has the capacity of allowing for dynamic real-time imaging of the pulmonary lesion and the chest wall. therefore, us has the potential to allow for the appreciation of subtle findings related to the movement of the lesion and lung over the chest wall. hence, us might be an accurate tool to assess chest wall invasion by lung cancer; thus improving pre-operative diagnosis, staging and operative planning of patient with chest wall invasion. however us is not currently utilized in the pre-operative assessment of patients with lung cancer invading the pleura and chest wall, and has not been extensively studied. in some rare studies evaluating the accuracy of us, results have shown a sensitivity ranging from 89% to 100% and a specificity ranging from 95% to 98% for us detecting chest wall invasion by lung cancer. however those studies got criticized. bandi et al study, got criticized by the fact that the operators in the study were experienced interventional pulmonologists who perform hundreds of thoracic and endoscopic ultrasound per year. nobuo et al study took place in 1993, since when the device of us has evolved, the investigators can not apply with certainty the findings of this study. consequently, there is a need to conduct a study to evaluate the accuracy of us to assess chest wall invasion by lung cancer. in this prospective study the investigators will assess the accuracy of us, and then compare it to the accuracy of the ct-scan


Eligibility criteria:
inclusion criteria: * patients with peripheral pulmonary nodules abutting the visceral pleura on pre-operative ct scan of the chest and who are booked for surgery. exclusion criteria: * inability to consent for the study. * patients less than 18 years old.

Keywords: lung cancer chest wall invasion transthoracic ultrasound
a comparison of local infiltration analgesia and pecs block for analgesia in mastectomy with axillary dissection - an equivalence study

Conditions: Mastectomy; Lymphedema; Local Infiltration; Anesthesia, Local; Block

Summary: the investigators aim to compare the quality of pain relief provided by local infiltration analgesia delivered by surgeon and pecs block delivered by anaesthetist under ultrasound guidance for patients undergoing mastectomy with axillary dissection.

total breast removal with armpit dissection may be a painful surgery. pectoral nerve block (pecs block) is common pain relief method used to reduce pain after breast surgery. the pecs block is a pain relief method technique at targeted body part. the pecs block numbs nerves which supply sensation to the upper chest wall, armpit and upper arm. this procedure is only possible under ultrasound guidance and is carried out by the anaesthetist (medical specialist who administers anaesthetics) after patients are put under general anaesthesia. despite the advantages of pecs block in pain management, this method is not always available to all patients due to various reasons. these reasons include the availability of ultrasound machine to facilitate the method, presence of anaesthetist to carry out the procedure and additional time required to perform this method in the operating theatre. another method has been modified by our surgeons (medical specialist who performs surgery, a different specialty from anaesthetist) to achieve pain relief among patients undergoing breast removal surgery. this method is called local infiltration analgesia (lia). the pain control is achieved by having the surgeons to deliver a pain control drug surgically during the breast removal operation. lia could be a good pain control alternative when a pecs block could not be performed. the investigators hope to compare the quality of pain relief provided by local infiltration analgesia delivered by surgeon and pecs block delivered by anaesthetist under ultrasound guidance. the investigators hope to show that lia delivered by surgeon is as effective as pecs block in patients undergoing mastectomy with axillary dissection.

Eligibility criteria:
inclusion criteria: * age above 21 years old * able to give consent * body weight \> 50kg exclusion criteria: * patient's refusal and inability to give consent * allergy or contraindicated to local anaesthetics, paracetamol, nsaids or opioids * background history of chronic pain * bilateral procedures
pulsed radiofrequency treatment in lumbar facet-related pain

Conditions: Facet Joint Pain; Pain Syndrome; Pain, Chronic

Summary: facet joint-related pain is one of the leading causes of low back pain. facet joint-related disorders can have a negative impact on quality of life and daily living activities, in addition to the pain.conservative treatment methods such as analgesic medications, physical therapy, and manual therapy are used for facet joint-related low back pain, and interventional pain management practices are used in patients who do not respond adequately to these treatments. pulse radiofrequency application, which is a recent popular treatment in interventional pain management, is also frequently applied in the treatment of facet-joint related pain. pulsed radiofrequency intervention can be applied directly intra-articularly or can be applied to the median branch, which is important structure in pain transmission. although both methods are frequently used in pain management, there is a lack of information in the literature about which is more effective. this study aimed to compare the treatment results of intraarticular pulse radiofrequency application and median branch pulse radiofrequency application in facet joint-related low back pain.


Eligibility criteria:
inclusion criteria: * having facet joint-related low back pain at least 3 months * no response to other conservative treatments (analgesic medications, physical therapy, manuel therapy etc.) * patients with a pain severity score of at least 6 according to nrs exclusion criteria: * history of lumbar region surgery * patients with bleeding disorders * presence of pregnancy and breastfeeding status * presence of the infection related findings and any other systemic disorder * history of allergic reaction to contrast agent * patients who do not have sufficient mental function to fill out the scales during the follow-up periods
the molecular screening study for the umbrella trial (sukses) in relapsed small cell lung cancer patients [sukses-s]

Conditions: Small Cell Lung Cancers; Neuroendocrine Carcinoma

Summary: this protocol is a molecular screening protocol only. no drug intervention study will be included in this protocol. based on the molecular profiling, patients may be eligible for drug intervention study of sukses trial. this procedure can be performed during or after the first-line treatment. dna will be extracted from the archived or fresh tissue and blood. ngs-based cancer panel and nanostring cnv will be tested with dna from tissue and/or blood. immunohistochemistry and fish will be done by pathologists using archived or fresh tissue. tumor tissues (fresh or archival) will be analyzed using ngs-based cancer panel, nanostring cnv, immunohistochemistry and/or fish. specific methods of each molecular tests will be defined with standard laboratory manual developed by pathologists.

this protocol is a molecular screening protocol only. no drug intervention study will be included in this protocol. based on the molecular profiling, patients may be eligible for drug intervention study of sukses trial. this procedure (molecular profiling) can be performed before, during, or after the initial treatment. dna will be extracted from the archived or fresh tissue and blood. ngs-based cancer panel and nanostring cnv will be tested with dna from tissue and/or blood. immunohistochemistry and fish will be done by pathologists using archived or fresh tissue. in addition, blood collection will be conducted at baseline (initial), three weeks, six weeks, twelve weeks, and subsequent imaging. tumor tissues (fresh or archival) will be analyzed using ngs-based cancer panel, nanostring cnv, immunohistochemistry and/or fish. specific methods of each molecular tests will be defined with standard laboratory manual developed by pathologists.

Eligibility criteria:
inclusion criteria: 1. provision of fully informed consent prior to any study specific procedures. 2. patients must be ≥20 years of age. 3. histologically or cytologically confirmed small cell lung cancers 4. ecog performance status of 0 to 2 5. patients who are being treated or were treated with platinum-based chemotherapy as a first-line treatment 6. patients with available archival tissues for molecular analysis or patients who agreed with biopsy for molecular analysis exclusion criteria: 1. more than two prior chemotherapy regimen for the treatment of small cell lung cancer 2. pregnant or nursing women (women of reproductive potential have to agree to use an effective contraceptive method) 3. patients with second primary cancer, except: adequately treated non-melanoma skin cancer, curatively treated in-situ cancer of the cervix, or other solid tumours curatively treated with no evidence of disease for ≤2 years.
neurovascular coupling in patients with open angle glaucoma

Conditions: Glaucoma

Summary: a variety of studies demonstrate that ocular blood flow is altered in glaucoma. various animal and human studies have shown an increase in retinal and optic nerve head blood flow in response to diffuse luminance flicker. based on studies with erg, this effect has been attributed to augmented activity in the retinal ganglion cells and associated axons indicating a coupling mechanism between neuronal activity and retinal blood flow. whereas a variety of studies have confirmed these effects, the knowledge about this coupling in the retina of patients with glaucoma is sparse. recently the investigators could show that flicker induced vasodilatation is blunted in patients with open angle glaucoma. however, the investigators results are limited by the fact that only data about retinal vessel diameters, not blood flow per se, are available. the further development of the investigators current flicker stimulation technique now allows us to determine blood flow velocity during flicker stimulation. thus, in the current study, the investigators set out to determine whether this blood flow response is impaired in patients with glaucoma as compared to those in healthy volunteers and whether this is related to altered neural activity. the study objective was, to investigate whether the blood flow response to flicker stimulation is altered in patients with glaucoma.


Eligibility criteria:
inclusion criteria: * men and women aged between 20 and 80 years. * normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant. * inclusion criteria of patients are open angle glaucoma. * men and women will be included in equal parts. a pregnancy test will be performed at screening. * ametropia of less than 3 diopters and anisometropia of less than 1 diopter. exclusion criteria: * treatment with vasoactive drugs. * presence of intraocular pathology other than open angle glaucoma. * presence of ocular hypertension or pex (pseudoexfoliation) glaucoma * history or family history of epilepsy. * pregnancy. * diabetes mellitus.

Keywords: glaucoma ficker stimulation ocular blood flow
stem cells treatment for the local urinary incontinence after a radical prostate cancer surgery (hulpuro)

Conditions: Urinary Incontinence

Summary: the purpose of this study is to evaluate the feasibility and security of the autologous e-asc for the urinary incontinence after a radical prostate cancer surgery


Eligibility criteria:
inclusion criteria: 1. signed informed consent 2. men over 18 years old. good general state of health according to the findings of the clinical history and the physical examination 3. prostate cancer diagnosed subjects via a biopsy and having had a radical surgery with a healing purpose in the previous 18 months 4. having urinary incontinence after the surgery 5. failure in any previous conservative treatment exclusion criteria: 1. having had an adjuvant treatment 2. having a psa ≥ 0,2 after surgery 3. having any sign or symptom that suggest the investigator the non-healing of the adenocarcinoma 4. active urine infection 5. alcohol or other addictive substances abuse antecedents in the previous 6 months to the inclusion 6. cardiopulmonary illness that, in the investigator opinion, could be unstable or could be serious enough to drop the patient from the study 7. any kind of medical or psychiatric illness that, in the investigator opinion, could be a reason to exclude the patient from the study 8. subjects with congenital or acquired immunodeficiencies, b and/or c hepatitis, tuberculose or treponema diagnosed at the moment of inclusion 9. anesthetic allergy 10. major surgery or severe trauma in the previous 6 months 11. administration of any drug under experimentation in the present or in the previous 3 months before recruitment

Keywords: urinary incontinence autologous expanded stem cells radical prostate cancer surgery