Kornimate/medical-research-clean huggingface dataset:
dim light at night in patients with obstructive sleep apnea

Conditions: Obstructive Sleep Apnea (OSA)

Summary: with the advent of electricity, light at night has become a ubiquitous part of our society. the main purpose of this study is to determine whether sleeping with dim light (40 lux), the brightness of a night light) in your bedroom for 5 consecutive nights will result in increased markers of inflammation in the blood compared to sleeping in darkness during the night in patients with obstructive sleep apnea (osa). a secondary aim is to examine the effects on insulin sensitivity, other blood proteins, and rna molecules as a result of sleeping with dim light. rna molecules are substances in blood that dictate what type of proteins the body should make.

the primary objective of this study is to determine whether sleeping with dlan (40 lux) for 5 consecutive nights will result in increased markers of inflammation compared to sleeping in darkness (\< 1 lux) during the night in patients with osa. a secondary aim is to examine the effects on insulin sensitivity, adipokines, and rna molecules. the risks associated with this study are minimal compared to the potential benefits. knowledge about the effects of sleeping with dim light on inflammation in patients with osa is important and would guide future recommendations about proper sleep hygiene. this research may also guide future recommendations about light conditions in other environments such as hospital bedrooms.

Eligibility criteria:
inclusion criteria: * • 18 -60 years of age. * willing and able to give informed consent * ahi \>10 episodes per hour based on a prior psg. * patients who have been started on treatment for osa with either continuous positive airway pressure (cpap) or dental device will be eligible for the study as long as they have been compliant with treatment for at least 30 days. exclusion criteria: * • incapable of giving informed consent * under the age of 18 * currently sleeping with lights on in the bedroom * excessive alcohol consumption * excessive alcohol use is defined as: * more than 3 glasses of wine a day * more than 3 beers a day * more than 60 ml of hard liquor a day * room air oxyhemoglobin saturation \< 88% * use of home oxygen * use of corticosteroids and other immunosuppressive medications. * diagnosis of: hiv, connective tissue disease (lupus, rheumatoid arthritis), inflammatory bowel disease.
matched pair study - kinematic vs mechanical alignment

Conditions: Osteoarthritis, Knee; Joint Disease

Summary: the aim of this study is to evaluate postoperative knee function after total knee arthroplasty performed according to the anatomical alignment and compare these results to those of a matched historical cohort of patients operated with mechanical alignment.

the 25 patients, of the kinematic group, are prospectively enrolled. while, the data of patients of the mechanical group, are retrospectively collected from an historical collection.

Eligibility criteria:
inclusion criteria: 1. patients presenting with disease that meets the indications for use for medacta implants defined by this study (on-label use). 2. patients necessitating primary total knee replacement 3. patients who are willing and able to provide written informed consent for participation in the study. written informed consent must be obtained prior to the patient's surgery. exclusion criteria: 1. those with one or more medical conditions identified as a contraindication defined by the labeling on medacta implants used in this study. 2. previous osteotomy around the knee 3. ligament instability likely to require higher level of constraint 4. previous infection or inflammatory disease 5. extraarticular deformities for which a femoral intramedullary guide rod can't be inserted into the canal and use of computer assisted orthopaedic surgery (caos) or patient specific instrumentation (psi) is required.
improvement in wound healing with negative pressure wound therapy for postoperative total hip arthroplasty

Conditions: Complications; Arthroplasty, Infection or Inflammation; Wound Complication

Summary: for the target population of adult patients following primary total hip arthroplasty, the randomized clinical trial will be used to evaluate the efficacy of the use of a mobile negative pressure wound therapy(npwt) device compared to a standard absorptive dressing in the immediate postoperative period. we will apply two dressing types and evaluate the postoperative wounds with a wound scoring system (asepsis) that incorporates multiple variables of wound infection risk.


Eligibility criteria:
inclusion criteria: - adult patients undergoing primary total hip arthroplasty. exclusion criteria: * age less than 18 y/o * total hip arthroplasty for fracture * revision or conversion total hip arthroplasty * inability to personally consent to participation due to cognitive impairment, intoxication or sedation * multiple surgical procedures * patients taking immune modulating medication(prednisone, methotrexate, anakinra, etc.) * skin hypersensitivity to acrylic adhesive or silver. * inability to care for dressing due to physical or mental incapacitation
treadwill, an automated intervention for depressive symptoms

Conditions: Depressive Symptoms

Summary: treadwill is a fully automated digital intervention that provides a multi-modal treatment for depressive symptoms. it includes: 1. slides and interactive text-based conversations based on cognitive behavioral therapy (cbt); 2. mindfulness videos; 3. game-based cognitive bias modification paradigms; 4. an empathetic chatbot. this study's primary aim is to test the differential effectiveness of this full-featured version of treadwill compared to a text-based cbt program.

treadwill is an online tool to deliver automated intervention for depressive symptoms. treadwill helps the participants learn the concepts of cognitive behavioral therapy (cbt), and practice mindfulness in an interactive manner. it also has games based on cognitive bias modification (cbm) and an empathetic chatbot. we hypothesize that participants using treadwill will show a significant reduction in depressive symptoms and will show engagement with the program. to test this hypothesis, we are conducting a randomized controlled trial. we will randomize participants into three groups: experimental, active control, and waitlist. participants randomized to the experimental group will get access to the full-featured version of treadwill as described above. participants randomized to the active control group will have access to a limited version of treadwill designed to deliver basic cbt in plain text format. the waitlisted participants will be put on a waitlist for 6 weeks.

Eligibility criteria:
inclusion criteria: * fluent in english * phq-9 score from 5 to 19 * access to an internet-enabled android smartphone * plan to use treadwill in google chrome browser * agree to allow notifications from treadwill * agree to add treadwill to home screen * have email on one of the html-enabled platforms including gmail, outlook, yahoo, rediffmail, aol, hotmail. exclusion criteria: * suicide ideation (score greater than 0 on the 9th question of phq-9 and score greater than 4 on siq) * unemployed * current or previous diagnosis of bipolar disorder/manic-depressive disorder or psychosis * prospective participants who say they only want to check out the program and do not plan to complete it are excluded. * used an earlier version of treadwill

Keywords: depression anxiety ccbt cbm chatbot cbt mindfulness
the feasibility of a physical activity intervention for advanced multiple myeloma patients

Conditions: Multiple Myeloma; Hematologic Neoplasms; Advanced Cancer

Summary: although physical activity (pa) is commonly used to manage symptoms and enhance quality of life (qol) in cancer survivors, relatively little is known regarding the benefits in advanced multiple myeloma (mm). the primary aims of the physical activity in advanced cancer treatment (paact) intervention were to examine (1) program feasibility and (2) potential impact on patient outcomes. it is hypothesized that an exercise intervention will be feasible and potentially impactful.

while the introduction of novel and more effective treatments has seen improved survival in multiple myeloma (mm), the aggressive nature of the disease and these corresponding agents can have a debilitating impact on quality of life (qol). exercise can help manage symptoms and enhance qol in cancer survivors, however relatively little is known regarding the feasibility or benefits of exercise in mm. the purpose of this study was to examine the feasibility of a group- and home-based exercise intervention for individuals with advanced mm. in this single arm study, advanced mm patients (ds stage ii-iii) participated in a 12-week aerobic and resistance training intervention, with the option of palliative care consultation. participants attended once weekly supervised group exercise classes and received individually tailored home exercise booklets. validated measures of physical functioning and patient-reported outcomes, including qol, fatigue, anxiety, depression, and self-compassion were obtained at baseline and 12-weeks (post-intervention). optional semi-structured interviews were conducted halfway (week 6) and at the end of the intervention (week 12)

Eligibility criteria:
inclusion criteria: * diagnosed with advanced (durie-salmon stage ii-iii) multiple myeloma * 18 years of age or older and given a survival prognosis greater than 6 months * stable hemoglobin level of ≥80g/l as measured within 2 weeks of enrollment * no active infections at the time of enrollment. exclusion criteria: * refusal of informed consent * geographically inaccessible * non-english speaking * co-morbidities that interfere with participation (i.e., severe mobility issues or cognitive impairments) * known or active history of substance abuse

Keywords: physical activity exercise hematology intervention supportive cancer care multiple myeloma resistance training
effect of skate skin extract on cognitive function in adults

Conditions: Subjective Memory Impairment

Summary: the investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of skate skin extract on cognitive function in adults with subjective memory impairment for 12 weeks.

previous animal studies have indicated that skate skin extract may have the ability to improve cognitive function. therefore, the investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of skate skin extract on cognitive function in adults with subjective memory impairment for 12 weeks; the safety of the compound are also evaluate. the investigators examine chemical and metabolic parameters, and cognitive function at baseline, as well as after 6 and 12 weeks of intervention. one hundred adults were administered either 500 mg of skate skin extract or a placebo each day for 12 weeks;

Eligibility criteria:
inclusion criteria: * global deterioration scale (gds) 2 or 3 exclusion criteria: * abnormal liver or renal function (i.e., serum aminotransferase activity \> 3 times of upper limit of reference range and serum creatinine concentrations \> 1.2 mg/dl) * diabetes (diagnosed clinically or fasting glucose level \> 126 mg/dl) * history of viral hepatitis or cancer * uncontrolled hypertension * history of serious cardiac disease such as angina or myocardial infarction * history of gastrectomy * history of medication for psychiatric disease * administration of oriental medicine including herbs within the past 4 weeks
the bochum optimizing clopidogrel-aspirin therapy and mortality study (bocla-mort)

Conditions: Coronary Artery Disease

Summary: comparing standard treatment versus optimized antiplatelet therapy and outcomes measures.

the study is aimed to evaluate if optimized antiplatelet treatment using a test and treat algorithm (with whole blood aggregometry) is able to improve clinical outcome of patients compared to standard treatment without platelet function testing.

Eligibility criteria:
inclusion criteria: * coronary stent implantation exclusion criteria: * no consent

Keywords: clopidogrel aspirin low response platelet aggregation acute coronary syndrome coronary stent implantation
ultrasound guided local anesthetic block: thoracolumbar interfascial plane

Conditions: Healthy

Summary: the purpose of the study is to determine the effectiveness of a new approach to numbing (anesthetizing) nerves in the back and to measure how far the area of anesthesia extends on the skin of the back.

this research aims to define a novel field-infiltration nerve block. we will use ultrasound guidance to inject local anesthesia into the potential space between the muscle bodies of the erector spinae. the medial branch of the dorsal ramus of each thoracolumbar nerve innervates the muscle and skin overlying the erector spinae muscle to the midline. by anesthetizing each nerve we believe minimally invasive (1-2 level) back surgery may be completed with less pain and preclude the side-effect laden opioid analgesics.

Eligibility criteria:
inclusion criteria: * healthy adult exclusion criteria: * pregnant women (a urine pregnancy test will be done on all females of childbearing age) * liver dysfunction * elderly * impaired cardiovascular function * individuals on amiodarone or history of back surgery * history of medical allergy to local amide type local anesthetics * medical allergy to chlorhexidine * history of paresthesias * inability to lay flat * home oxygen requirement * history of seizures * only adults will be eligible.

Keywords: volunteer pilot study adults
trial to assess safety, tolerability, and immunogenicity of influenza virus vaccine, trivalent, types a & b, live cold-adapted (flumist) and measles, mumps, rubella, and varicella vaccines administered concurrently to healthy children

Conditions: Influenza

Summary: * to compare immune responses to measles, mumps, rubella, and varicella antigens following vaccination in children who receive flumist concurrently with mmriiò and varivaxò and in children who receive an intranasal placebo mist concurrently with mmriiò and varivaxò (group 2 vs. group 1). * to compare immune responses to the three strains of influenza (h1n1, h3n2, and b) following a two dose regimen of flumist in children who receive the initial flumist dose concurrently with mmriiò and varivaxò and in children who receive two doses of flumist alone (group 2 vs. group 3).secondary: * to assess the safety and tolerability of concurrent administration of flumist with mmriiò and varivaxò.


Eligibility criteria:
inclusion criteria: * 12 to 15 months of age (not reached their 16th month birthday); * in good health; * parent/guardian available by telephone or for home visits; * ability of the parent/guardian to understand and comply with the requirements of the protocol; * signed informed consent by parent/guardian; and * up to date with the primary series of recommended vaccines per standard clinic practice and local vaccine availability. exclusion criteria: * previous known measles, mumps, rubella or varicella disease; * previous vaccination against measles, mumps, rubella or varicella disease; * hypersensitivity to egg or egg protein; * signs or symptoms of any immunosuppressive or immune deficiency disease or ongoing immunosuppressive therapy; or an immunosuppressed individual living in the same household; * acute febrile (\>100.0of \[37.8°c\] oral) illness or clinically significant upper respiratory illness within the 72 hours prior to enrollment; * use of aspirin (acetylsalicylic acid) or aspirin-containing products in the month prior to enrollment, or expected use of aspirin while enrolled in this study; * administration of any intranasal medication within two weeks prior to enrollment or expected receipt during this study; * administration of any live virus vaccine within one month prior to enrollment through 30 days after visit 3; * administration of any inactivated vaccine within two weeks prior to enrollment through 30 days after visit 3; * participation in another investigational trial within one month prior to enrollment or expected enrollment in another investigational trial during this study; * receipt of any blood product within three months prior to vaccination or expected receipt within the study duration; and * any condition which, in the opinion of the investigator, would interfere with the interpretation or evaluation of the vaccines. * history of two or more episodes of medically attended wheezing illness by parent/guardian report. * history of medically attended wheezing illness or bronchodilator medication use within four weeks of enrollment by parent/guardian report.
observational study to assess the effect of iluvien® in dme patients insufficiently responsive to available therapies

Conditions: Diabetic Macular Edema (DME)

Summary: this observational study aims to assess the safety and effect of iluvien® in dme patients considered insufficiently responsive to available therapies in a real life setting in germany.


Eligibility criteria:
inclusion criteria: * adult patients of both sexes that have signed informed consent after detailed information about the characteristics of the observation by the physician * dme based on physician's clinical evaluation and demonstrated on fundus photographs and/or optical coherence tomography (oct); * vision impairment associated with dme * prior treatment with available therapies for dme; and * patients considered by the physician insufficiently responsive to available therapies exclusion criteria: * patients with contraindications according to the current summary of product characteristics (spc) * the presence of pre-existing glaucoma * active or suspected ocular or periocular infection * the patient is hypersensitive to the active agent or to one of the excipients * elevated iop * pregnancy or breastfeeding
fetal brain ultrasound

Conditions: Fetal Anomaly

Summary: the aim of our study is to determine the range of frontal horn sizes (both upside and downside) in healthy fetuses over gestation and to determine how far fhs are from the midline . also to determine the range of cavum septi pellucidi and corpus callosum sizes . also, to determine whether the maternal body mass index (bmi) affects rates of visualized and non-visualized csp and cc.

fetal central nervous system (cns) abnormalities are among the most commonly encountered congenital abnormalities . many different methods can be used to obtain prenatal diagnoses, including ultrasound (us), which is one of the most commonly used methods .neonatal survival rates have increased over the last decades leading to increased number of infants with adverse neurodevelopmental outcomes, including cognitive, motor impairments and behavioral and learning difficulties later in life . recent studies demonstrated that signs of abnormal neurological development are already present at birth . frontal horns (fhs) are the most anterior portions of the lateral ventricles, on each side the cavum septi pellucidi (csp). in accordance with practice parameters released as early as 1985 by the american institute of ultrasound in medicine, american college of obstetrics and gynecology, and society of radiologists in ultrasound, the csp is examined in screening fetal ultrasound (us) examinations in the biparietal diameter view . frontal horns (fh) are also visualized in the same plane. abnormal morphologic characteristics of the fhs such as enlargement, squaring, spearing, and splaying may have an association with congenital intracranial anomalies such as holoprosencephaly, schizencephaly and agenesis of the corpus callosum . the corpus callosum (cc) is the largest interhemispheric white matter commissure of the human brain . it is a sensitive indicator of normal brain development and maturation

Eligibility criteria:
inclusion criteria: * pregnant woman 15 weeks to 36 weeks exclusion criteria: * congenital malformations * multiple pregnancy * intrauterine infection * fetuses with fetal growth restriction
mindfulness-based exercise video in educating hispanic/latino patients with colorectal cancer and their caregivers

Conditions: Anxiety Disorder; Colon Cancer; Depression; Fatigue; Rectal Cancer

Summary: this randomized pilot trial studies mindfulness-based program in educating patients with colorectal cancer and their caregivers. a mindfulness-based exercise video may help reduce stress and fatigue in patients with colorectal cancer and their caregivers.

primary objectives: i. to evaluate the effect of a brief educational program on colorectal cancer knowledge acquisition in a 3-arm randomized clinical trial (control group: standard of care; treatment group 1: cancer education; treatment group 2: mindfulness + cancer education) comparing visual/written educational material with and without mindfulness training to the standard of care. ii. to determine the priming effect of a brief mindfulness training on retaining knowledge of colorectal cancer education. iii. to determine the joint effect of colorectal cancer education delivered to both the patient and a caregiver on the overall colorectal cancer knowledge. secondary objectives: i. to examine the relative changes in psychobiological variables (stress, anxiety, depression, mindfulness, fatigue, life benefit) from pre (t0) to post (t1) intervention in the 3 arms of the clinical trials. ii. to measure changes in salivary cortisol levels as an indicator of acute stress reactivity across 4 time points across a one-hour period (i.e., 0 min, 20 min, 40 min, 60 min) during active chemotherapy (t1). iii. to determine the moderating effect of baseline peripheral levels of inflammation (interleukin-1 \[il-1\], il-6, c-reactive protein \[crp\] and tumor necrosis factor alpha \[tnfa\]) on the trajectory of salivary cortisol reactivity. outline: patients and caregivers are randomized to 1 of 3 groups. group i: patients and caregivers receive standard of care. group ii: patients and caregivers receive a 20-minute self-playing interactive educational video brochure. group iii: patients and caregivers receive a 20-minute self-playing interactive educational video brochure and watch a 20-minute interactive mindfulness exercise video.

Eligibility criteria:
inclusion criteria: * patient diagnosed with colorectal cancer * patients with at least one more chemotherapy appointment at the time of enrollment * if patients have a caregiver, patients should agree to bring a caregiver to one of their hospital visits or have the caregiver schedule a separate study visit * ability to understand and the willingness to sign a written informed consent exclusion criteria: * illiterate participants * deaf participants * participants that do not read speak or understand either spanish or english