Kornimate/medical-research-clean huggingface dataset:
integrating hcv and hiv screening during the era of hiv antigen testing

Conditions: HIV; Hepatitis C

Summary: the objective of this proposal is to develop an optimal testing strategy for hcv and hiv in high prevalence settings, such as detoxification centers with a large proportion of young injection drug users. the latest venipuncture testing will be compared to rapid finger stick testing for hcv and hiv. outcomes for each strategy among individuals admitted at a short-term drug detoxification center will be determined.


Eligibility criteria:
inclusion criteria: * age greater or equal to 18 * all clients admitted to btc with a history of drug or alcohol use * individuals who self-report as being hiv and hcv non-infected within the past 6 months or having unknown status * participants providing contact information of two family members or friends * individuals signing a medical records release form for the referral site (boston medical center) * english speaking exclusion criteria: * individuals unable to provide informed consent * individuals with a known history of hcv and/or hiv
retrospective long-term safety and efficacy study of the beta-cath(tm) 3.5f system

Conditions: Coronary In-stent Restenosis

Summary: the study will evaluate the long-term safety and efficacy of intravascular beta radiation therapy to treat coronary in-stent restenosis using the beta-cath(tm) 3.5f system; data will be collected retrospectively on patients treated with the beta-cath™ 3.5f system in routine clinical practice following fda pre-market approval of the system. outcomes will be reported up to 5 years following treatment.


Eligibility criteria:
inclusion criteria: * patients who underwent on-label treatment (as defined below) with the beta-cath™ 3.5f system (30, 40 or 60mm) for in-stent restenosis (isr) after coronary stenting. 1. on-label treatment for the 30 and 40mm beta-cath™ 3.5f system is defined as: treatment of isr in native coronary arteries with discrete lesions (treatable with a 20mm balloon) in reference vessel diameters (rvd) ranging from 2.7mm to 4.0mm 2. on-label treatment for the 60mm beta-cath™ 3.5f system is defined as: treatment of isr in native coronary arteries with lesions \<40mm in length in rvd ranging from 2.7mm to 4.0mm * patients must have undergone brachytherapy treatment at least 6-8 months prior to enrollment in this retrospective study and the date of their treatment must be: 1. on or after february 8, 2002 for the 30/40mm 3.5f system 2. on or after june 25, 2003 for the 60mm 3.5f system exclusion criteria: * patients who do not give informed consent * patients who do not meet the inclusion criteria

Keywords: coronary brachytherapy coronary restenosis coronary in stent restenosis
effectiveness of corneal accelerated crosslinking for infectious keratitis

Conditions: Keratitis

Summary: the objective of this study is to evaluate the efficacy and safety of accelerated cross-linking (avedro inc., waltham, usa) in the management of microbial keratitis as adjunctive therapy.

investigators perform a comprehensive ophthalmological examination, including evaluation of risk factors (immunosuppressive status, ocular trauma, previous ocular surgery, contact lens wear, topical corticosteroids use), best-corrected visual acuity (snellen chart), slit-lamp biomicroscopy, tonometry and fundoscopy. in addition, anterior segment optical coherence tomography imaging (visante, carl zeiss meditec, dublin, california, usa), corneal scrapes, culture and clinical photographs at day 1, day 7, month 1 and 3 will be analyzed. each participant will be assigned to one of four groups after randomization. group 1: initial ulcer on treatment with antibiotic plus sham (n = 66), these partcipants will receive only topical moxifloxacin 0,5% (vigamoxi, alcon, texas, usa) and sham cxl; group 2: initial ulcer on treatment with antibiotic plus cross-linking (cxl) (n = 66) receive moxifloxacin plus cxl (riboflavin 0.1% during 10 minutes and irradiation 30 mw/cm2 during 3 minutes using accelerated cxl); group 3: refractory corneal ulcer on treatment with antibiotic plus sham (n=66), receive only topical antibiotic plus sham cxl; group 4: refractory corneal ulcer on treatment with antibiotic plus cxl will receive their standard medications plus cxl. statistical analysis will be divided into four phases: 1) analysis of compliance, 2) intention to treat, 3) losses to follow-up and 4) variable-response (healing) using stata/mp 12.0 (stata corp., college station, tx).

Eligibility criteria:
inclusion criteria: * subjects with infectious keratitis (initial or refractory to treatment) including bacterial or mycotic keratitis with size larger than 3 mm exclusion criteria: * herpetic keratitis * acanthamoeba keratitis * pregnancy * endophthalmitis * systemic immunosuppression

Keywords: infectious keratitis cross-linking
improving health behavior and outcomes after angioplasty

Conditions: Angioplasty

Summary: the objective of this randomized trials is to evaluate, among coronary artery disease patients who have just had either angioplasty or stents, whether a novel intervention based on feedback of individualized risk profiles framed as the opportunity to reduce one's biological age is more effective after two years in reducing mortality and major cardiovascular morbidity (specifically, myocardial infarction, stroke, class ii-iv angina, and severe ischemia) than the standard risk reduction approach, which is framed as one's opportunity to reduce future risk. the novel strategy is based on the theory of net-present value and is tested in coronary artery disease patients who have a high risk of adverse outcomes by two years.

1. to determine whether patients who receive the net-present value intervention have more improvements in their risk factor profile than those in the control group at two years. 2. to determine whether the net-present value intervention will enable patients to sustain behavioral change over the long-term. 3. to determine whether the net-present value intervention will improve overall functional status and prevent further disability. the long-term objective of this study is to determine whether a net-present value approach for motivation behavior change is effective in reducing risk factors, improving treatment outcomes, and enhancing quality of life among a high-risk group of patients.

Eligibility criteria:
inclusion criteria: * all patients undergoing coronary artery catheterization who are found to have at least single vessel stenosis and who have had revascularization with angioplasty or coronary artery stenting will be eligible for enrollment. patients must be able to provide informed consent within the one week after the procedures. exclusion criteria: * patients must be verbally fluent in english. to ascertain this, we ask the patient to rate their fluency on a scale of 1-10 (with 10 as best), and if the score is 7 or more, they are approached for consent. the patient must be able to provide their own consent without translation. * enrollment in other trials designed to modify post-procedure behaviors. * patients who refuse to participate will be excluded. * if at any time prior to enrollment in the study, the patient's cardiologist determines that the patient should not participate in this study, the patient will not be enrolled in the trial.

Keywords: angioplasty motivating behavior change reducing risk factors enhancing quality of life improving treatment outcomes
fascial release on upper cross syndrome.

Conditions: Upper Cross Syndrome

Summary: this study will be a randomized controlled trial conducted to investigate the effect of release of upper track of deep front fascial line on patients with upper cross syndrome.a sample size of 40 will be randomly allocated to two group ,(20 participants in each group), by using computer-generated random number list method. experimental group will receive release of upper track of deep front fascial line in addition supervised corrective exercises for upper crossed syndrome and control group which will receive supervised corrective exercise only. both groups will receive eight sessions (2 sessions per week for 4 weeks).

upper cross syndrome is a characterized by muscular imbalance of skeletal muscles activation and inhibition rather than just single muscle involvement. individuals who present with upper crossed syndrome will show a forward head and neck posture working in abnormal posture for prolonged duration is the main risk factor. although this posture does not necessarily lead to pain, but when prolonged, individuals do often experience upper back and neck pain.stress on cervico-cranial and cervico-thoracic junction is caused by the poor posture .some postural patterning of forward shoulders, increases kyphosis, forward head posture, and loss of cervical lordosis is created by this poor posture. many researches studied effect of exercises, stretching ,muscle energy technique,active release technique.research on fascia gains more and more attention in basic science. fascial tissue plays an important role not only in functional anatomy,but also in sport and exercise science as well as in numerous therapeutic approaches as well as in clinical rehabilitation.accordingly,there is no studies in the literature investigated the the effect of release of upper anterior track of deep front fascial line in subjects with upper cross syndrome, therefore this is the purpose study.

Eligibility criteria:
inclusion criteria: 1. age ranged from 18 to 40 years. 2. body mass index ≤30 kg/m². 3. all participants have forward head ,craniovertebral angle less than 48-50 degrees. 4. all participants have round back(kyphosis angle ≥ 42°). 5. the subjects were chosen from both genders. 6. based on assessment for upper cross syndrome by photogrammetric analysis exclusion criteria: 1. history of trauma or surgery in cervical region. 2. bone fractures or acute soft tissue injuries . 3. osteoporosis . 4. heart attack . 5. unstable angina pectoris . 6. implanted pacemaker or defibrillator . 7. pregnant women. 8. cancer . 9. rheumatoid arthritis. 10. connective tissue disease: this includes diseases such as osteomyelitis, lupus and scleroderma. 11. neurological conditions. -
evaluating motivation and reward mechanisms and brain substrates in adults with obesity

Conditions: Anhedonia; Obesity

Summary: anhedonia and abnormalities in reward behavior are core features of overweight/obesity (ow), a highly prevalent condition within mdd populations, and is independently associated with reward disturbances. the investigators therefore aim to investigate the brain substrates subserving reward and motivation in adults with overweight/obesity. the primary aim of this pilot study is to determine whether associations exist between obesity and decreased performance on the respective motivation/reward paradigms.

herein, the investigators are primarily interested in three overlapping, yet distinct aspects, of anhedonia. the investigators are primarily interested in motivation, reward valuation, and reward learning towards addressing the measurement of each of these respective subdomains, eligible participants will complete validated gold standard measures (i.e. the effort expenditure for rewards task (eefrt) (reward valuation), probabilistic reward task (prt) (reward learning), and the monetary incentive delay (mid) task (reward anticipation)). twenty adults with overweight/obesity will complete all tasks at a single visit with two of the tasks being completed prior to mri and one of the tasks (i.e. eefrt) will be completed during mri acquisition. the primary aim of this pilot study is to determine whether associations exist between obesity and decreased performance on the respective motivation/reward paradigms. in addition, associations between performance on reward tasks and functional connectivity, as measured by mri and dti, a secondary objective is to ascertain whether associations exist between performance on the motivation reward tasks and gold standard measures of food intake (i.e. food diary) and energy expenditure (i.e. calorimetry).

Eligibility criteria:
inclusion criteria: * 18-65 years of age * meeting dsm-v criteria for: (i) major depressive disorder (symptomatic or asymptomatic in any phase of the illness) or (ii) bipolar disorder i/ii (symptomatic or asymptomatic in any phase of the illness) * ability to provide written and informed consent * obesity 30 kg/m2 * weight under 440lbs * shoulder-to-shoulder width under 60 cm exclusion criteria: * age below 18 or above 65 * use of benzodiazepines or consumption of alcohol within 12 hours of assessments * abuse of marijuana * physical, cognitive, or language impairments sufficient to adversely affect data derived from assessments * diagnosed reading disability or dyslexia * clinically significant learning disorder by history * history of moderate or severe traumatic brain injury * other neurological disorders, or unstable systemic medical diseases * pregnancy and post-partum period * presence of any contra-indications for mri * weight above 440lbs * shoulder-to-shoulder width greater than 60 cm. all subjects will be consented prior to initiating the study; \>45 bmi; suicidality as determined by clinical discretion
postoperative enteral immunonutrition in gastric cancer

Conditions: Gastric Cancer

Summary: immunomodulating enteral nutrition in the perioperative period may reduce postoperative complications in cancer patients. little is known if this effect translates to the better survival. the aim of study was to assess the impact of postoperative immunomodulating enteral nutrition on postoperative complications and survival of gastric cancer patients. the group of 98 gastric cancer patients were randomly assigned for postoperative immunomodulating enteral nutrition n=44 (reconvan ,fresenius kabi), or standard enteral nutrition n=54 (peptisorb, nutricia). postoperative complications, mortality, 6-month, 1-year and 5-year survival were analyzed.

treatment of gastric cancer often requires major surgery and carries the risk of postoperative complications and fatal outcomes. mortality rates after gastrectomy due to gastric cancer have been reported as 2-5%, while the incidence of postoperative complications was 10 to over 40%. immunomodulating enteral nutrition in the perioperative period may reduce postoperative complications in cancer patients. little is known if this effect translates to the better survival. the aim of study was to assess the impact of postoperative immunomodulating enteral nutrition on postoperative complications and survival of gastric cancer patients. the group of 98 gastric cancer patients were randomly assigned for postoperative immunomodulating enteral nutrition n=44 or standard enteral nutrition n=54. following the initial randomization, the patients received either standard nutrition (oligopeptide, low-fat, isocaloric, non-residue diet - peptisorb, nutricia) or immunomodulating nutrition (protein rich, isocaloric, no-residue diet including arginine, glutamines and omega-3 fatty acids - reconvan, fresenius kabi). postoperative complications, mortality, 6-month, 1-year and 5-year survival were analyzed.

Eligibility criteria:
inclusion criteria: * gastric cancer confirmed in histopathological examination * elective operation due to gastric cancer * informed consent signed * age \> 18 years * normal nutritional status or mild to moderate malnutrition exclusion criteria: * severe malnutrition which required parenteral nutrition * urgent operation

Keywords: immunonutrition gastric cancer enteral nutrition
the effect of midwifery care given to couples experiencing pregnancy loss on grief and general well-being

Conditions: Pregnancy Loss; Grief; Loss Pregnancy; Care Pattern, Maternal; Bereavement

Summary: this study was designed as a randomised controlled, 2-group, pre-test-post-test comparative, experimental study to increase the general well-being of women experiencing pregnancy loss and to decrease the level of perinatal grief.

objective: the aim of this study was to examine the effect of midwifery care and counselling based on swanson care theory for couples experiencing pregnancy loss on womens perinatal grief and general well-being levels. method: the study had an experimental two-group pretest-posttest design. midwifery care and counselling based on swanson care theory is a grief support program consisting of eight interviews, including four face-to-face interviews after the woman\&#39;s admission to the clinic and four telephone interviews until the 30th day after discharge. the study was conducted with 76 couples admitted to the obstetrics and gynecology department of a training and research hospital in istanbul between august 2023 and may 2024 with a diagnosis of pregnancy loss. the intervention group (n=38) received midwifery care and counselling based on swanson care theory in addition to routine midwifery care in accordance with clinical procedures, whereas the control group (n=38) received only routine midwifery care in accordance with clinical procedures. this study used the women experiencing pregnancy loss introductory information form, men experiencing pregnancy loss introductory information form, perinatal bereavement scale, and general well-being scale.

Eligibility criteria:
inclusion criteria * to agree to participate in the research with a partner. * speak and understand turkish. * to be 18 years of age or older. * to be at least primary school graduate. * having experienced loss after spontaneous pregnancy. * not being diagnosed with a psychiatric illness. exclusion criteria: * pregnancy loss due to medical termination * being pregnant with assisted reproductive techniques and experiencing pregnancy loss

Keywords: midwifery pregnancy loss perinatal bereavement bereavement care guide midwifery care and counselling
evaluation of success rate of partial pulpotomy versus complete pulpotomy in primary molars using neoputty mta

Conditions: Pulp Disease, Dental

Summary: evaluating the clinical and radiographic success of partial pulpotomy compared to complete pulpotomy in vital primary second molars with reversible pulpitis using neoputty™ (mta).

children with symptoms of reversible pulpitis in their second primary molar will be chosen to be enrolled in the study, and then randomly allocated into two groups. one group will undergo partial pulpotomy and the other group complete pulpotomy and followed up for 12 months. the blinding of the operator is not possible due to the nature of the technique used. trial participants, outcome assessors and statistician will be blinded. 1. informed consent from participating children's parents. 2. baseline records photographs, percussion test, periapical radiograph and personal data collection. 3. diagnostic chart with personal, medical and dental history will be filled. 4. allocation (concealed by withdrawing a sealed opaque envelope containing four-folded numbered papers containing the type of vital pulp therapy technique that will be used then writing the patient's name and i.d. on it and will be opened after removing the carious lesion). 5. clinical examination will be performed to assess the clinical inclusion criteria. (pulpal and periapical diagnoses are established after clinical examination). 6. preoperative and postoperative photographs will be taken.

Eligibility criteria:
inclusion criteria: * patients: * aged 4-7 years, in good general health and medically within normal. teeth: * restorable mandibular second primary molars. * history of reversible pulpitis. preoperative radiograph: * absence of periapical or inter-radicular radiolucency. * absence of widening of periodontal ligaments (pdl) space. * absence of internal or external root resorption. exclusion criteria: * patients: * with systemic disorders. * physical or mental disabilities. * unable to attend follow-up visits. * refusal of participation. * refusal to sign the informed consent. teeth: * previously accessed teeth. * mobile mandibular second primary molar. * swelling in the vestibule or on palpation. * pain on percussion.
effects of a vitality dietary supplement on physical and mental function in middle-aged adults

Conditions: Health-related Quality of Life

Summary: the purpose of the study is to determine the effects of 8 weeks vitality product supplementation on physical and mental function in middle-aged adults


Eligibility criteria:
inclusion criteria: * males and females aged 40-70 years * signed informed consent * bmi between 19 and 30 kg/m2 * normotensive, defined as systolic blood pressure 90-140 mmhg and diastolic blood pressure 50-90 mmhg exclusion criteria: * regular dietary supplement use and unwilling to discontinue use at least 1 month prior to enrollment in the study * self-reported chronic condition that may affect subject safety (e.g. diabetes, cardiovascular disease) or significantly impact product effectiveness (e.g. chronic fatigue) * pregnancy/suspected pregnancy, breastfeeding * antihypertensive medication use * allergies to any supplement ingredients * consumption of more than 600mg caffeine from any source per day * consumption of "energy drinks" (e.g. red bull, monster) or any herbal supplement known to affect energy levels * known iron anemia * medically treated for insomnia * medically treated for depression * taking medications known to affect energy, e.g. thyroid medication * tobacco user * planned surgical procedure in next 2 months * participating in another clinical (medical or nutritional) study or likely to enroll in another medical or nutritional study
lesion detection of automated breast ultrasound compared with handheld physician-performed breast ultrasound

Conditions: Breast Diseases

Summary: compare lesion detection of the automated breast ultrasound (abvs) exam with the conventional handheld (hh) breast ultrasound (us) exam.

this is a research study to test a fda-approved automated breast ultrasound (abvs) machine in subjects recommended for an ultrasound of the breast. the main purpose of the study is to compare images obtained from the automated breast ultrasound exam with the standard physician performed handheld breast ultrasound exam for lesion detection equivalence. each subject will have a bilateral hand-held breast ultrasound and a bilateral automated breast ultrasound, both exams preferably done on the same day. the hand-held ultrasound will be performed by a breast imaging physician participating in the study and the automated ultrasound exam will be performed by a sonographer. there is no radiation risk from ultrasound. the physician performing the handheld breast ultrasound is blinded to the study, will not know the subject's history, but only the reason for the breast ultrasound exam. the automated scan requires gentle pressure on the breast during a scan. three basic views will be acquired for each breast, each scan lasting approximately one minute. once all necessary views are acquired, the images will be sent to a remote workstation, where a second radiologist, also blinded to the results of the handheld study, will interpret the automated ultrasound. once all images and patient information are gathered, the study radiologists will review the previous images, if available, to provide the final result that will determine clinical management. therefore, it is possible that the hand-held or automated ultrasound scan will lead to further evaluation of the breast and possibly a biopsy.

Eligibility criteria:
inclusion criteria: * anyone who is referred for an ultrasound of the breast exclusion criteria: * subjects whose breast thickness is greater than 6 cm.the maximum depth of image filed for the abvs acquisition is 6 cm