Kornimate/medical-research-clean huggingface dataset:
comparison of synera patch versus lmx-4 cream versus placebo patch for pain reduction during venipuncture in children

Conditions: Pain; Venipuncture; Anesthetics, Local

Summary: the purpose of this study is to compare the effect of synera patch versus lmx-4 cream and placebo on the level of pain, observed distress, difficulty of venipuncture and skin side effects in children undergoing intravenous blood draw in the emergency setting or the phlebotomy lab.

this study will compare the effectiveness of a patch applied for 30 minutes (synera-lidocaine 70 mg/tetracaine 70 mg) with the effectiveness of a cream (lmx-4- 4% liposomal lidocaine) and a placebo patch applied for the same length of time in reducing pain due to needle sticks in children. one hundred fifty children and adolescents 5-17 years old admitted to emergency department or presenting to the phlebotomy lab. will be randomly placed in each group. children will rate their level of pain using the faces pain scale-revised (fps-r) before the medication is applied, after the medication is removed and after the needle stick. parents and research observer will fill out the observed behavioral distress (obd) score. the phlebotomist will rate how difficult it was to perform the needle sticks. any skin reaction seen by the investigator after the cream or patch is removed will be noted and compared among the three groups. subjects will be monitored from the time of enrollment to 5 minutes post phlebotomy.the time frame for which data will be presented is one (1) year.

Eligibility criteria:
inclusion criteria: * children requiring venipuncture for medical care * the ability to demonstrate proper understanding of the faces pain scale-revised (fps-r) * parents of enrolled children need to be present during the procedure and be willing to rate their child's pain exclusion criteria: * damaged or inflamed skin at the designated application site * known sensitivity to components of synera or lmx-4 (lidocaine, tetracaine, or local anesthetics of the amide or ester type, paba derivatives) * contraindications to synera or lmx-4 use (severe hepatic disease, history of drug-induced methemoglobinemia, taking class 1 antiarrhythmics) * use of analgesics during the past 24 hours * teenage female participants who are pregnant or lactating * if in the attending's judgment the patient cannot wait wait 30 minutes for a blood drawn. these conditions include but are not limited to: sepsis, trauma, surgical emergencies, severe dehydration.

Keywords: pain children local anesthetics
adductor canal block and arthroscopic knee surgery, high pain responders

Conditions: Arthroscopic Knee Surgery

Summary: the investigators want to explore the analgesic effect of adductor canal blockade (a peripheral nerve block) in high pain responding patients after arthroscopic knee surgery. the investigators hypothesize that the nerve block will have an abrupt analgesic effect.


Eligibility criteria:
inclusion criteria: arthroscopic knee surgery, if reconstruction of anterior cruciate ligament only hamstring graft 18-80 years of age bmi 18-40 asa i-iii written consent exclusion criteria: unable to communicate in danish, allergic reactions toward any study medication pregnancy alcohol/drug abuse daily opioid consumption scin infection (injection site)

Keywords: minor arthroscopic knee surgery including acl-reconstruction (hamstrins graft) high pain responders adductore canal block analgesics ultrasound guided nerve block
therapeutic gain by induction-concurrent chemoradiotherapy and/or accelerated fractionation for nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma

Summary: the objectives of this clinical study are threefold: 1. to compare the benefits in cancer control and survival obtained from adding induction-concurrent chemotherapy to radiation with those from adding concurrent-adjuvant chemotherapy to radiation. 2. to test whether replacing fluorouracil with xeloda in combining with cisplatin in the chemotherapy plan will maintain or improve further the chemotherapy benefits while reducing the duration of hospital stay. 3. to see if accelerated fractionation radiotherapy can improve the outcome of patients as compared with conventional fractionation radiotherapy.

1. primary objectives include 1. comparing induction chemotherapy with cisplatin + 5-fluorouracil versus adjuvant chemotherapy with cisplatin + 5-fluorouracil(pf-pvs p-pf) 2. comparing induction chemotherapy with cisplatin + capecitabine versus adjuvant chemotherapy with cisplatin + 5-fluorouracil(px-p vs p-pf) 3. comparing accelerated fractionation versus conventional fractionation (af vs cf)radiotherapy. 2. secondary objectives include 1. comparing induction chemotherapy with cisplatin + capecitabine versus induction chemotherapy with cisplatin + 5-fluorouracil(px-p vs px-p) 2. comparing concurrent-adjuvant (ca) versus induction-concurrent (ic) chemotherapy sequence.

Eligibility criteria:
inclusion criteria: * histologically proven nasopharyngeal carcinoma for primary treatment with radical intent * non-keratinizing or undifferentiated type * stage iii-ivb (by ajcc/uicc 6th edition) * ecog performance status less or equal to 2 * marrow: wbc \>= 4 and platelet \>=100 * renal: creatinine clearance \>=60 * informed consent exclusion criteria: * primary treatment with palliative intent * who type i squamous cell carcinoma or adenocarcinoma * evidence of distant metastases * patient is pregnant or lactating * prior malignancy except adequately treated basal cell or squamous cell skin cancer, in-situ cervical cancer or other cancer for which the patient has been disease-free for 5 years

Keywords: nasopharyngeal carcinoma chemoradiotherapy accelerated fractionation
the efficacy and safety of dwp16001 compared to placebo in the treatment of type 2 diabetes mellitus.

Conditions: T2DM (Type 2 Diabetes Mellitus)

Summary: the purpose of this study is to determine the efficacy and safety of dwp16001 compared to placebo in the treatment of type 2 diabetes mellitus.


Eligibility criteria:
inclusion criteria: 1. adults aged 19 to 80 years 2. subjects with 7% ≤ hba1c ≤ 10% who have been diagnosed with t2dm at least 8 weeks 3. subjects with bmi of 20-45 kg/m2 4. subjects who have been on a stable diet and exercise program for at least 8 weeks 5. subjects who voluntarily decided to participate and provided written consent after being told of the objectives, method, and effects of this study exclusion criteria: 1. different type of diabetes mellitus which is not t2dm (type 1 diabetes mellitus, secondary diabetes mellitus, or congenital renal glucosuria) 2. symptoms of stress urinary incontinence, dysuria that is not controlled by medications due to neurogenic bladder or prostatic hyperplasia, anuria, oliguria, or urinary retention 3. severe diabetes complications (proliferative diabetic retinopathy, nephropathy of stage 4 or higher, or serious diabetic neuropathy) 4. egfr \< 60 ml/min/1.73 m2 5. severe gastrointestinal diseases: active ulcer, gastrointestinal or rectal bleeding, active inflammatory bowel syndrome, biliary duct obstruction, active gastritis that is not controlled by medication, etc. 6. uncontrolled hypertension (sbp \>180 mmhg or dbp \> 110 mmhg)
outcome of transanal specimen extraction surgery for elderly colorectal cancer patients

Conditions: Colorectal Cancer

Summary: retrospective analysis of a cohort of elderly crc patients (aged ≥ 65 years) underwent transanal-noses between august 2008 and february 2022 was constructed. data were obtained from china noses database (cndb). the primary outcomes included time to first flatus, postoperative hospital stays, 30-day postoperative complication and hospital mortality. the secondary outcomes were overall survival (os) and disease-free survival (dfs).


Eligibility criteria:
inclusion criteria: patients diagnosed as t1-4n0-2m0 colorectal cancer pathologically patients underwent transanal-noses patients aged 65 years or older exclusion criteria: patients with multiple primary colorectal cancer patients with total colectomy patients without complete data

Keywords: survival
the alzheimer's companion engagement (ace) project.

Conditions: Stress, Psychological; Adaptation, Psychological

Summary: black family caregivers of older adults with alzheimer's disease and/or related dementias (adrd), have an increased mortality risk related to pre-existing health conditions and stress. targeted, culturally responsive, health interventions that help black adrd caregivers to effectively manage their own health and use community preferenced ways of coping, can improve caregivers' overall health, perceived ability to provide care for a person with adrd (self-efficacy), and increases the likelihood that they will experience benefits from caregiving. this clinical trial pilot will test the feasibility of a community based intervention designed to improve health outcomes for black family caregivers of persons with adrd.

the proposed intervention is a peer-supportive and facilitator-led video teleconference program that will engage small groups of caregivers weekly over 6 weeks. each week participants (n = 36, 2-5/group) will receive a different culturally relevant caregiving or personal health strategy to practice. during the support calls, a facilitator will provide an overview of the content covered and each participant will have the opportunity to discuss their past week and how they engaged the weekly strategy, or challenges that came up for them during the week. the format will be structured to ensure that core content is reviewed, and everyone can be equally engaged while flexible enough that caregivers can receive support in the areas they need. a battery of assessment measures will be taken at weeks 1 and 8.

Eligibility criteria:
inclusion criteria for participation are as follows: self-identified as black/ african american at least 18 years old able to speak, understand, and hear spoken english related to, or has a close personal relationship to a person over the age of 55 that has an adrd diagnosis or evidence of cognitive impairment regular access to a smartphone, tablet or computer with internet access that will allow video conferencing engagement. provides monitoring, and assistance in activities of daily living and or other care tasks for the care recipient. -
effect of kinesio taping and sham taping in knee osteoarthritis

Conditions: Osteoarthritis

Summary: the prevalence of knee osteoarthritis has been increasing in recent decades as the number of obese people has increased. various interventions are used to improve the functional condition of patients, but it is still not clear which one is most effective. the primary aim of this study was to determine and compare the effects of kinesio taping and sham taping on the knee functional mobility.

the investigators assigned 30 adult participants (26 women, 4 men; mean age 58,1±3,9 yrs) from lithuania. participants were assigned to one of three groups: control group (con) (n = 10), sham taping + exercise (ste) (n = 10), and kinesio taping + exercise (kte) group (n = 10). participants performed all necessary tests according to the study protocol one week before the intervention. a second set of tests was performed one week after the intervention. the intervention duration was 1 week. exercise, sham and kinesio taping were applied by physical therapist. all the study groups did exercise training.

Eligibility criteria:
inclusion criteria: * clinical and radiography diagnosis of osteoarthritis of the knee joint * patients with different degrees of severity of the knee osteoarthritis * consent to participate in the study. exclusion criteria: * rheumatoid arthritis * systemic connective tissue disease * knee joint oedema * surgery intervention in recent 6 months * wearing of knee braces * skin problems * previous total or partial knee replacement surgery * inability to perform physical examination tests * oncology * use of medications, infection * previous experience of kinesio taping intervention.

Keywords: kinesiotaping functional mobility physiotherapy knee pain
a study evaluating the addition of mabthera (rituximab) to standard treatment in patients with idiopathic thrombocytopenic purpura (itp)

Conditions: Idiopathic Thrombocytopenic Purpura

Summary: this study will compare the efficacy, safety, and pharmacokinetics of standard treatment versus standard treatment plus mabthera in patients with itp. the anticipated time on study treatment is \<3 months, and the target sample size is 100-500 individuals.


Eligibility criteria:
inclusion criteria: * adult patients \>=18 years of age; * untreated itp. exclusion criteria: * itp with relapse; * positive test result for hiv or hepatitis b or c; * active infection requiring systemic therapy; * malignancy within 3 years before study.
belun ring platform with an improved algorithm for osa assessment

Conditions: Sleep-Disordered Breathing; Sleep Architecture

Summary: osa is commonly diagnosed with either attended in-lab polysomnography (psg) or unattended home sleep apnea testing (hsat). the bls-100 (belun technology company limited, hong kong) is a novel neural network-based hsat platform consists of a ring shape pulse oximeter sensor, a cradle, and an improved proprietary analytic algorithm. this study investigates the hypothesis that the bls-100 is a reasonable hsat device for osa assessment.


Eligibility criteria:
inclusion criteria: * provision of signed and dated informed consent form. * age 18-80 * clinically assessed and suspicious for osa exclusion criteria: * full night pap titration study * on home o2, noninvasive ventilator, diaphragmatic pacing, or any form of nerve stimulator * having atrial fibrillation-flutter, pacemaker/defibrillator, lvef \< 55%, left ventricular assist device (lvad), or status post cardiac transplantation * patients taking narcotics * recent hospitalization or recent surgery in the past 30 days * unstable cardiopulmonary status on the night of the study judged to be unsafe for sleep study by the sleep tech and/or the on-call sleep physician an individual who meets the above criteria but fails to have at least 4 hours of technically valid sleep based on bls-100 in a diagnostic study or at least 3 hours of technically valid sleep during the diagnostic portion of a split night study will be excluded from statistical analyses.

Keywords: obstructive sleep apnea wearable home sleep apnea testing photoplethysmography validation artificial intelligence
epley manoeuvre in participants with multiple sclerosis diagnosed from benign paroxysmal positional vertigo

Conditions: Benign Paroxysmal Positional Vertigo; Multiple Sclerosis

Summary: vertigo, dizziness and control postural disturbance are one of the most disabling symptoms in multiple sclerosis. these could be caused by a peripheral or central vestibular disorder. although, central vestibular damage is more prevalent, peripheral vestibular disturbance aetiology is significantly common in this disease. within peripheral vestibulopathy, benign paroxysmal positional vertigo is the most common syndrome. impairments of posterior semi-circular canals in benign paroxysmal positional vertigo represent among the 60-90 % of the cases. gold standard treatment in this syndrome is the canalith repositioning procedure, called epley manoeuvre. this manoeuvre has been deeply investigated in previous studies for participants who only suffer from benign paroxysmal positional vertigo. any randomized clinical trials have been carried out to assess the effectiveness of epley manoeuvre. however, a retrospective research and a case study reported encouraging results for the resolution of posterior semi-circular canal benign paroxysmal positional vertigo, through the epley manoeuvre. the main objective of the study is to assess the effectiveness of the epley manoeuvre for the improvement of the benign paroxysmal positional vertigo of participants with multiple sclerosis, compared to a passive control group.

after given oral and written information to participants, they will be freedom to decide their wish to participate. after the invitation, those participants who desire to be part of study will sign the written informed consent.the study describes a two-arms, parallel groups design and double-blind randomized clinical trial. a prospective study with randomized and conceal allocation will be performed to prevent possible bias. participants and evaluators will be blinded to group allocation. the randomized controlled trial have 3 evaluations of the sample, that will be carried out at baseline, immediately after intervention and 48 hours later

Eligibility criteria:
inclusion criteria: * adults of both genders aged from 18 to 65 years old. * clinically diagnosed of any ms subtype (relapsing-remitting, primary progressive and secondary progressive), * with an expanded disability status scale (edss) ranging from 1 to 5 points, * diagnosed of posterior semi-circular canals benign paroxysmal positional vertigo by an otolaryngologist and a physical therapist expert in vestibular rehabilitation. exclusion criteria: * changes in ms pharmacotherapy within the last 3 months, * bppv treatments as vestibular sedatives, corticosteroids, morphic and antihistamines, at least 72 hours before intervention, * alcohol consumption in the last 72 hours, * severe visual impairments, * participants who have received vestibular rehabilitation within the last 3 months, * existence of any other neurologic disease.

Keywords: multiple sclerosis benign paroxysmal positional vertigo epley manoeuvre vertigo dizziness
ultra sound guided genicular nerves cooled radiofrequency ablation in total knee replacement surgeries

Conditions: Osteoarthritis of Knee

Summary: total knee replacement surgery is common procedure that is usually done for patients suffering from persistent pain with limitation of movement. unfortunately, they do suffer after the operation as it is associated still with significant pain that affect the rehabilitation plan, hospital length of stay, life style and patient satisfaction. new approaches are rising every day to add to the multimodal management plan. genicular nerves cooled radiofrequency ablation is a new approach that can be simply done u.s. guided with little side effects, if any, and great results.

the study measures the efficacy of genicular nerves cooled radiofrequency ablation in enhancing quality of rehabilitation in patients undergoing total knee replacement

Eligibility criteria:
inclusion criteria:• undergoing a scheduled unilateral total knee replacement surgery - exclusion criteria: * • allergy to any of the drugs used in the study * alcohol or drug abuse * psychiatric disease
the role of extracorporeal shock wave therapy in the treatment of trapezial-metacarpal osteoarthritis. a double blind randomized controlled study.

Conditions: Osteoarthritis Trapezial-metacarpal Joint

Summary: evaluate if extracorporeal shock wave therapy is more effective than sham treatment in patients with trapezial-metacarpal osteoarthritis in pain relief and functional improvement.


Eligibility criteria:
inclusion criteria: * according to the eaton et al. classification the inclusion criteria involved those patients with stage iii, participants had to have a history 6 months of pain and they were 18 years of age or older. exclusion criteria were also the presence of degenerative or non-degenerative neurologic conditions, in which pain perception is altered, a history of coagulopathy, cancer, cardiac pacemaker, calcaneal fracture, and pregnancy. exclusion criteria: * exclusion criteria were also the presence of degenerative or non-degenerative neurologic conditions, in which pain perception is altered, a history of coagulopathy, cancer, cardiac pacemaker, calcaneal fracture, and pregnancy.
multimodality evaluation of left ventricular remodeling in mitral regurgitation: a pilot study

Conditions: Left Ventricular Systolic Dysfunction

Summary: the purpose of this research is to determine the feasibility of a larger, future study proposing a multimodal approach using cardiac ct and mri to assess the risk of developing left ventricular (lv) systolic dysfunction in patients with mitral regurgitation (mr).


Eligibility criteria:
inclusion criteria: * age \>= 18 * male or female * a diagnosis of severe chronic primary mitral regurgitation * undergoing isolated robotic mitral annuloplasty at mayo clinic rochester * patients must have the ability to consent or have an appropriate representative available to do so. exclusion criteria: * prior valve intervention, * concomitant valve surgery at the time of mitral annuloplasty (e.g. tricuspid annuloplasty, aortic valve replacement). * concomitant \>= moderate regurgitation or stenosis in any other valve by preoperative echocardiography * history of prior myocardial infarction * history of cardiomyopathy unrelated to mitral regurgitation (e.g. dilated, hypertrophic, infiltrative) * pregnancy. women of childbearing potential will be verbally screened by clinical staff during as part of routine pre-mri evaluation. if a subject is unsure whether they could be pregnant, a negative pregnancy test will be performed prior to scanning. * implantable devices that would be a contraindication to mri * severe allergy to gadolinium mri contrast
feasibility of the management of severe cervical dysplasia in a single visit

Conditions: Cervical Intraepithelial Neoplasia

Summary: 1. implement a single-visit program (svp) for cervix cancer prevention in clinics serving a multi-ethnic population of women; 2. set up an efficient system for interpretation of pap smears for patients in the svp that will minimize waiting time; 3. determine the follow-up rates and compare them between women assigned to the svp and a usual care program (ucp); 4. determine satisfaction and compare it between women assigned to the svp and the ucp; 5. determine the cost-effectiveness and compare it between the svp and ucp

women were recruited from underserved communities to participate in this single visit cervix cancer project. large loop electrosurgical excision procedure (leep) was performed on svp subjects with either a diagnosis of hgsil/agus or suspicion of carcinoma. all other subjects with abnormal papanicolaou smears were referred to our abnormal cytology clinics or received care in the community.

Eligibility criteria:
inclusion criteria: * older than 18 years * no history of invasive cervical cancer * not pregnant exclusion criteria: * absence of a cervix * abnormal vaginal bleeding * cervical cancer screening within the previous 12 months * a known bleeding disorder * reluctance to be randomized * unwillingness to follow the study protocol
comparison between low pressure versus high pressure laparoscopic cholecystectomy

Conditions: Cholelithiasis

Summary: the physiological changes and postoperative pain are directly related with the degree of intra-abdominal pressure kept during the laparoscopy. the present study aims to examine difference between low pressure pneumoperitoneum (8 mm hg)and high pressure pneumoperitoneum (12 mm hg)during laparoscopic cholecystectomy in terms of pain, cardio-pulmonary function, arterial blood gas changes etc.


Eligibility criteria:
inclusion criteria: * symptomatic gall stone disease exclusion criteria: * pyocele * gangrene of gall bladder * history of cholangitis * simultaneous cbd stones * gall stone pancreatitis * who does not give consent if they will be randomized to lplc

Keywords: laparoscopic cholecystectomy low pressure pneumoperitoneum