Kornimate/medical-research-clean huggingface dataset:
right sided colon polyp miss rate: impact of retroflexion in the right colon

Conditions: Colon Polyps; Colon Cancer Screening

Summary: colonoscopy is the gold standard screening test for colorectal cancer. removal of pre-malignant colon polyps during colonoscopy reduces colorectal cancer mortality by over 50%. however, while colonoscopy is highly effective at preventing distal (left sided) colon cancers, it provides only limited protection from cancer in the proximal (right side) colon. our goal is to determine if additional pre-cancerous colon polyps can be identified by looking at the right side of the colon in retroflexion. during retroflexion the tip of the colonoscope is turned 180 degrees; allowing the doctor to view the backs of colonic folds. if additional polyps can be identified in this manner colonoscopy will become a more efficient method of screening for colon cancer. in order to evaluate how effective right colon retroflexion is at detecting polyps in the proximal colon we plan on performing a randomized, controlled trial. patients undergoing screening or follow up colonoscopy will be invited to participate in the study. those patients who agree to participate will be randomized into one of two groups once the colonoscope is fully inserted. group one will have the right side of their colon examined for polyps with the endoscope looking forward (traditional form of examination) followed by repeat examination of the right side of the colon with the colonosocpe in retroflexion (looking backwards). polyps seen during each section of the exam will be removed and manner in which the polyps were found/ removed will be recorded. following the two exams of the right side of the colon the colonoscopy will be completed in the usual manner. the duration of each portion of colonoscopy will be recorded. after the procedure is completed the physician performing the colonoscopy will rate difficulty of the procedure and confidence with quality of the examination. pathology results for each polyp will be recorded once available. there will be no study related follow up after the pathology results are recorded.


Eligibility criteria:
inclusion criteria: * • patients \>18 years of age undergoing colonoscopy for colorectal cancer screening or routine polyp surveillance exclusion criteria: * • failure to intubate the cecum during colonoscope insertion * prior right colon resection * known polyposis syndrome or polyposis identified at colonoscopy * inflammatory bowel disease * preparation of the colon is judged fair or poor using boston bowel preparation scale.

Keywords: colon polyps colon cancer screening colonoscopy
evaluation of uterine patency following sonography-guided transcervical ablation of fibroids

Conditions: Uterine Fibroids; Adhesions

Summary: this study is designed to observe the presence or absence of intrauterine adhesions at 6 weeks after treatment with the sonata® system through hysteroscopic evaluation by third party readers.

patients who agree to participate in this observational trial will have selected fibroid treatment with the sonata system. research participants will undergo hysteroscopy at 6 weeks following treatment to evaluate presence or absence of intrauterine adhesions. research participants will be asked to complete a quality of life questionnaire prior to and 6 weeks following treatment. research participants will also complete a satisfaction survey and a diary that tracks their return to normal daily activities.

Eligibility criteria:
inclusion criteria: * have selected sonata for treatment of fibroids in the presence of heavy menstrual bleeding * presence of at least one submucous myoma (type 1, type 2) or transmural fibroid (type 2-5) * willing and able to read, understand, and sign the informed consent form and to adhere to all study follow-up requirements exclusion criteria: * preexisting adhesions within the endometrial cavity as indicated by an esh score ≥ i as determined by the investigator * one or more type 0 fibroids and/or endometrial polyps of any size * any reason for which, in the opinion of the investigator, the individual study patient is not appropriate or suitable for participation in this study
patient activation, counseling and exercise - acute leukemia (pace-al)

Conditions: Acute Leukemia

Summary: the purpose of this study is to test a new preventive and restorative intervention for patients with acute leukaemia undergoing consolidation chemotherapy, to measure and delineate the patients' treatment related symptom burden and to explore the effect of the intervention on length of hospital stay, duration of sick leave and return to work status. further, to examine the relationship of the symptom profile with clinical indicators, physiological response, physical performance and survival.


Eligibility criteria:
inclusion criteria: * patients that are able to speak danish \> 18 years and newly diagnosed with acute leukæmia (mds, aml, cmml, apl or all) * normal ekg, blood pressure and pulse * signed informed written consent exclusion criteria: * medical reason that contraindicates physical activity * patients diagnosed with a symptomatic cardial disease * documented bone metastasis * cognitively or emotionally unstable * unable to read or write in danish * patients unable to carry out baseline tests

Keywords: #14 cancer related fatigue #13 quality of life #12 "psychosocial intervention"[ti/ab] #11 rehabilitation[tw] #10 "physical fitness"[tw] #9 "physical activity"[tw] #8 "exercise therapy"[tw] #7 exercise[tw] #6 hematologic[tw] #5 hematological[tw] #4 leukemia, myeloid, acute[mh] #3 "acute myeloid leukemia"[tw] #2 "acute lymphoblastic leukemia"[tw] #1 "acute leukemia"[tw]
progress at work - the impact of adalimumab on work related productivity in patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study is to describe the impact of treatment with adalimumab on work related productivity and economic burden in patients with rheumatoid arthritis (ra) treated in canada.


Eligibility criteria:
inclusion criteria: 1. subjects with moderate to severe ra for whom the physician has decided to initiate treatment with adalimumab 2. adult male or female ≥ 18 years old that has been newly prescribed adalimumab therapy according to the local product label and are with progress 3. subjects should be evaluated for tuberculosis (tb) exposure/risk factors for active and latent tb 4. subject is able to give written patient authorization and is willing to comply with the requirements of this study protocol. exclusion criteria: 1. subject cannot or will not sign a patient authorization 2. subject with a known hypersensitivity to adalimumab, or any of its components 3. presence of any condition that, in the opinion of the treating physician, prohibits the subject from participating in the study or obscures the assessment of the treatment of ra 4. subjects currently participating in an investigational clinical trial 5. subjects treated with \>1 prior biologic disease-modifying antirheumatic drugs (dmards) for ra. any prior treatment with adalimumab is prohibited 6. subjects previously treated with targeted synthetic disease modifying agent.
adequate sock to avoid hiking injuries

Conditions: Skin Lesion

Summary: foot lesions can be developed during hiking because of external factors. this makes it important to study the effect of hiking equipment on lesion development. this study analyzes the extrinsic factors involved in the appearance of injuries at the feet during the realization of a route of low difficulty and short travel. 33 participants wore cotton not technicians socks in his two feet, were used like control socks and 76 participants wore technical socks "tierra" and "set" one on each foot.

socks it used as an indispensable element to protect the foot of injuries during sports practice. the different compositions of socks can influence the appearance of injuries. the technical socks are designed for high-performance sports use ("lurbel" brand, models "tierra" and "set"), and non-technical socks (cotton) for everyday use. the socks had different composition: "tierra" (50% regenerative, 25% cool-teak, 17% polyamide ions, 8% lycra); "set" (75% cotton, 17% polyamide, 8% lycra) and cotton (98% cotton, 2% elastane). the technical socks had reinforced weave in the toe, metatarsal and heel areas.

Eligibility criteria:
inclusion criteria: * the admission criteria were: be of legal age, have no current health problems that would hinder or prevent participation in the hike, and carry a backpack weighing less than 3 kg. participants were asked to use specific hiking footwear (light, flexible, soft-soled, with good grip and breathable material) (low top hiking shoes), based on earlier studies 38-40. they were also asked to do the entire hike following the instructions of an experienced guide and to not remove their footwear or socks before examination by a podiatrist. exclusion criteria: * not meet any inclusion criteria.

Keywords: sport injury; technical socks; temperature; hiking
safety and efficacy study of the combined ablation procedure to treat paroxysmal atrial fibrillation

Conditions: Paroxysmal Atrial Fibrillation

Summary: this is a multi-center, prospective, open label, feasibility clinical study,evaluating the safety and efficacy of the combined ablation procedure for the treatment of symptomatic paroxysmal atrial fibrillation.

the purpose of this feasibility study is to evaluate the safety and efficacy of the epicardial / endocardial combined procedure for the treatment of drug refractory symptomatic paroxysmal atrial fibrillation (af) patients, using the ncontact numeris®-af guided coagulation system with visitrax® epicardially and the biosense webster navistar® thermocool® diagnostic/ablation deflectable tip catheter in conjunction with the carto navigation system endocardially.

Eligibility criteria:
inclusion criteria: * age \> 18 years; \< 80 years * left atrium less than or equal to 6.5 cm (tte) * symptomatic paroxysmal af * provided written informed consent * refractory to at least one aad (class i, ii, iii or iv) exclusion criteria: * patients requiring concomitant surgery * left ventricular ejection fraction \< 30% * pregnant or planning to become pregnant during study * co-morbid medical conditions that limit one year life expectancy * measured left ventricular wall thickness \> 1.5 cm * history of coagulopathy * previous cardiac surgery * right ventricular outflow tract obstruction * history of pericarditis * previous cerebrovascular accident (cva), excluding fully resolved tia * patients who have severe chronic obstructive pulmonary disease (copd) * patients who have an active infection or sepsis * patients who have uncorrected reversible cause(s) of af * patients who are contraindicated for anticoagulants * patients who are being treated for arrhythmias other than af * patients who have had any previous af or left atrial catheter ablation * current participation in another clinical investigation of a medical device or a drug, or recent participation in such a study within 30 days prior to study enrollment. * not competent to legally represent him or herself (e.g., requires a guardian or caretaker as a legal representative).

Keywords: paroxysmal atrial fibrillation af atrial fibrillation rf ablation
impact of discontinuing contact precautions for extended-spectrum β-lactamase enterobacteriaceae in a geriatric unit

Conditions: Infection, Hospital

Summary: this is an interventional multicenter prospective noninferiority non-randomized double-blind controlled before and after study. the aim of this study is to demonstrate that standard precautions alone are not inferior to contact precautions by comparing the incidence density of extended-spectrum β-lactamase (esbl)-producing enterobacteriaceae acquired in geriatric units before and after discontinuing contact precautions.

healthcare-associated infections (hais) are one of the main causes of morbidity and mortality worldwide. extended-spectrum β-lactamase (esbl)-producing enterobacteriaceae have become microorganisms frequently found in hais, which reduces the therapeutic possibilities.

Eligibility criteria:
inclusion criteria: * adult patient (\> 65 years old) * patient hospitalized in geriatrics during the study period * free and informed consent obtained from the patient (or his trusted person or legal representative) within 48 hours of its admission at the geriatric unit * patient affiliated to a social security scheme non inclusion criteria: * patient requiring contact precaution for an indication other than esble (covid-19, classical pcc excluding eblse, clostridium difficile pcc, scabies pcc and bhre pcc) on admission * patient under legal protection * person deprived of liberty exclusion criteria: * patient requiring contact precaution for an indication other than esbl during the patient stay (covid-19, classical pcc excluding eblse, clostridium difficile pcc, scabies pcc and bhre pcc) * patient's stay period less than 4 days
phase i/ii study of opb-31121 in patients with progressive hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: the purpose of this study is: phase1: to evaluate the safety and determine the recommended dose (rd) phase2: to evaluate the efficacy


Eligibility criteria:
inclusion criteria: * patients with histopathologically or clinically confirmed diagnosis of hepatocellular carcinoma * patients with child-pugh classification a or b * patients unresponsive to standard therapy or for whom standard therapy is intolerable, or for whom there is no appropriate therapy * patients who are able to take oral medication * patients age 20 to 79 years (inclusive) at time of informed consent * patients with an ecog performance status score of 0-2 * patients have the eligible organ function. exclusion criteria: * patients with a primary malignant tumor * patients with a history of liver transplant * patients with brain metastases * patients with a complication of uncontrolled * patients with a psychiatric disorder that might cause difficulty in obtaining informed consent or in conducting the trial

Keywords: hepatocellular carcinoma
management of pain in persons with multiple sclerosis

Conditions: Multiple Sclerosis; Pain

Summary: the purpose of this study is to see if treatments that include components of self-hypnosis training and cognitive behavioral therapy (cbt) can help decrease pain in people with ms.

this study examined the benefits of two treatments, individually and together, for helping individuals with ms manage their pain. we conducted a time series design in which ms subjects received all four treatment conditions in two orders (randomly assigned): (1) control (education intervention-cont),self-hypnosis training (hyp), cognitive behavioral therapy (cbt), hyp-cbt(a combination of hyp and cbt) and (2) cont, cbt, hyp, hyp-cbt. subjects attended 16 60-minute treatment sessions conducted by one of the study's psychologists either at the uw,hmc or in the subject's home. each subject received four treatment sessions of each treatment module listed above. primary outcome measures were collected via the telephone and mail by research personnel blind to the treatment condition before treatment, immediately after treatment ends and one month after treatment ends. secondary outcome measures were collected at the same assessment points via pencil and paper interviews completed by subjects.

Eligibility criteria:
inclusion criteria: * chronic ongoing pain (i.e., pain at all times) with an average pain intensity of at least 4/10 on 0-10 numeric rating scale * pain is either worse or started since the onset of other ms symptoms. * pain of at least six months duration. * reads, speaks and understands english. * definitive diagnosis of multiple sclerosis (ms) * at least 18 years of age * recruited from a recruitment source approved by the irb exclusion criteria: * severe cognitive impairment resulting in the inability to verbally comprehend, learn, and recall new auditory verbal information, as reflected by a tics score of 20 or less. * currently participating in counseling and/or psychotherapy more than once a week. * currently taking anti-psychotic medications * has been hospitalized for psychiatric reasons in the past six months * experiencing current active suicidal ideation. * has received treatment or participated in a clinical trial that involved significant elements of either cbt or hypnosis within the past year.

Keywords: pain management cognitive behavior therapy hypnosis
the effect of simulation-based breastfeeding education on breastfeeding self-efficacy and breastfeeding problems

Conditions: Postpartum Complication; Caesarean Section;Stillbirth

Summary: in the literature, there are studies conducted to determine the effect of simulation-based and different training techniques models given in the prenatal period on postpartum breastfeeding self-efficacy. however, no study was found that evaluated the effects of simulation-based and different training techniques given in the prenatal period on breastfeeding self-efficacy and breastfeeding problems. therefore, this study was planned to determine the effect of simulation-based breastfeeding education on breastfeeding self-efficacy and breastfeeding problems in the prenatal period.


Eligibility criteria:
inclusion criteria: * pregnants between32nd-36th gestational weeks, * primigravida, * planning to breastfeed, * can speak and understand turkish, * pregnant women who agreed to participate in the study were included. exclusion criteria: * breastfeeding contraindications, * having a risky pregnancy, having received a planned breastfeeding training before, * premature birth (before 37th weeks of gestation), * having a systemic/chronic disease
impact of pulmonary rehabilitation after lung resection for cancer on patients' level of anxiety and depression

Conditions: Pulmonary Resection

Summary: the interest of pulmonary rehabilitation for patients who underwent lung resection for cancer remains controversial. the investigators studied the effects of the rr and its impact on quality of life and level of anxiety and depression in patients. in 2011 and 2012 , an rr was proposed to the patients referred to our center after lung resection for cancer. patients were assessed at entry and departure by 6minutes walk test , a visual analog pain scale , a quality of life questionnaire ( eortc qlq c30 ) and an anxiety questionnaire and depression (had) . these same questionnaires were mailed 6 months after the end of the pulmonary rehabilitation .


Eligibility criteria:
inclusion criteria: * patient with pulmonary resection * patients undergoing a standardized approach (or thoratomie videothoracoscopy)
adolescent fibromyalgia study

Conditions: Fibromyalgia

Summary: this study will compare pregabalin with placebo over a 15 week period in adolescents with fibromyalgia aged 12-17 years to evaluate the safety and efficacy of pregabalin.


Eligibility criteria:
inclusion criteria: * diagnosis of fibromyalgia * 12-17 years of age exclusion criteria: * patients with other pain conditions * previous treatment with pregabalin * patients taking excluded medication

Keywords: juvenile primary fibromyalgia syndrome pediatric fibromyalgia pregabalin and lyrica
comparison of decolonization of methicillin-resistant staphylococcus aureus (mrsa) using theraworx

Conditions: Methicillin-Resistant Staphylococcus Aureus

Summary: the purpose of this study is to examine treatment method of methicillin-resistant staphylococcus aureus (mrsa) decolonization in patients.

decolonization therapy is indicated for management of patients with mrsa. theraworx is reported to be an effective antimicrobial against multiple organisms. in this study, patients with positive mrsa colonization culture will be treated with theraworx to evaluate decolonization duration capability.

Eligibility criteria:
inclusion criteria: * positive mrsa culture exclusion criteria: * patients currently on or start antibiotic therapy directed for mrsa.(prophylaxis antibiotic for surgical procedure not considered therapy.) * patients with mrsa infected wounds * patients under the age of 18 years * a woman currently pregnant or nursing a child * patients participating in another study within 30 days of randomization

Keywords: methicillin resistance
bictegravir/ftc/taf for the treatment of primary hiv infection

Conditions: HIV Primary Infection

Summary: the purpose of this study is to assess the efficacy of bictegravir/ftc/taf in patients with less of 100 days post hiv infection

after providing informed consent, patients will undergo to a screening visit. if they meet the inclusion criteria and none of the exclusion will be included in this trial. patients will take one tablet of biktarvy at day for 48 weeks. then the results will be compared with a cohort of 66 patients treated with 2 nucleoside analogues and one integrase chain transfer inhibitor.

Eligibility criteria:
inclusion criteria: * male and female patients aged 18-65 years * art naïve * hiv infection of less than 100 days post-infection (documented 3 month previous negative serology or incomplete wb test with negative p31 band) * women of child-bearing potential must have a negative pregnancy test in serum before the inclusion in the study and agree to use highly effective contraceptive methods, including intrauterine device, bilateral tubal occlusion or a vasectomized partner. exclusion criteria: * known hypersensitivity to any drug included in bictegravir/ftc/taf regimen * ast \>5 times unl * creatinine clearance \<30 ml/min/1.73m2 * any end-stage organ disease * acute or chronic hcv co-infection * use of prep with truvada® until 4 weeks before the onset of symptoms of phi (risk of acquired-drug resistance to fct or tdf).

Keywords: human immunodeficiency virus hiv primary infection biktarvy
talk therapy by phone to promote treatment for alcohol problems

Conditions: Alcohol Use Disorder; Alcohol Abuse

Summary: a small percentage of individuals with alcohol use disorder (aud) obtain alcohol-related care despite research showing that treatment is effective. this randomized controlled trial tests the efficacy of a brief, phone based cognitive behavioral intervention to increase treatment engagement, improve alcohol related outcomes, and show that treatment engagement is a mechanism for the improved outcomes in individuals with aud.


Eligibility criteria:
inclusion criteria: * age 18-plus; * score ≥ 16 on audit; * within the past 30 days, exceeding the limits for low-risk drinking adopted by niaaa: \>3 standard drinks on any occasion or \>7 drinks per week (women); \>4 drinks on any occasion or \>14 drinks per week (men). exclusion criteria: * unable to communicate with the researcher in english; * unable to comprehend the nature of the study; * history of alcohol-related care; * alcohol withdrawal necessitating medical evaluation; * residency outside of the greater rochester area.