Kornimate/medical-research-clean huggingface dataset:
high image matrix ct reconstruction

Conditions: Healthy Subjects; Pulmonary-Related Conditions; Cardiac-Related Conditions

Summary: background: computed tomography (ct) scans make detailed pictures of the body in seconds. ct scans make pictures by passing x-rays through a person. ct scans are common. in 2011, around 85.3 million of them occurred in the united states. researchers think ct images can be made better using new techniques. higher resolution images can be derived from the original scan. objective: to learn if new ways of obtaining and processing pictures of the body from a regular ct scan can produce images with higher resolution (pixels) and more information than standard methods. eligibility: people ages 18 and older who are scheduled to have a ct scan and are not pregnant design: participants will be screened with a review of their medical records. participants will have their scheduled ct scan. the ct scanner used in this study provides enhanced images of inside the body. researchers may use the ct scanner in a research mode to test and improve the pictures. images from the ct scan will be reviewed. any clinical findings from the ct test will be shared with the participant s doctor. participants will continue to receive their medical care from their regular doctor. the ct images will be entered into an nih research database. in the future, they may be used for research purposes.

computed tomography (ct) images the body. different methods of creating ct pictures are avilable on a research basis that enables higher resolution imaging using the same aquisition. the purpose of this research study is to learn wheteher these new high resolution images derived from the original ct scan provide similar or perhaps more information than the current standard clinical method.

Eligibility criteria:
* inclusion criteria: * clinical indication for ct * age equal to or greater than 18 years * able to understand and willing to sign the informed consent form exclusion criteria: -pregnancy

Keywords: computed tomography image reconstruction iterative reconstruction natural history
periostin and non-surgical periodontal treatment

Conditions: Periodontal Diseases

Summary: a total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. patients with periodontal disease received non-surgical periodontal treatment. gingival crevicular fluid periostin levels were assessed at baseline, at the 6th week and the 3rd month after treatment.

periostin is commonly found in collagen-rich tissues, which is thought to affect the production of collagen fibers. additionally, periostin is synthesized in tissues exposed to constant mechanical forces such as the periosteum, periodontal ligament, tendon, heart valve and skin. periostin mediates inflammation and fibrosis during diseases of various organs, including the heart, lung, kidney, skin, liver, skeletal muscle and retina. this study evaluated periostin levels in gingival crevicular fluid from patients with chronic periodontitis, gingivitis and periodontally healthy as well as the effect of non-surgical periodontal treatment on gingival crevicular fluid periostin levels.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of chronic periodontitis * clinical diagnosis of gingivitis * clinical diagnosis of periodontal health exclusion criteria: * have any systemic disease * to be alcohol consumer * to receive any periodontal therapy in the past 6 months * to take any drugs regularly * to be pregnant and/or lactate

Keywords: chronic periodontitis gingival crevicular fluid gingivitis non-surgical periodontal treatment periostin
study on the role of fdg-pet in patients with fl at time of relapse/progression

Conditions: Follicular Lymphoma

Summary: the study is designed as a retrospective analysis of patients with relapsed/refractory fl identified by the hematological centers of italy.

the study does not require any intervention on the patient, but it involves the simple collection of data that are already present in the medical record. since this is a retrospective study, it will not require further analysis or diagnostic investigations than those already made.

Eligibility criteria:
inclusion criteria: * patients with initial diagnosis of follicular lymphoma since 2001 * histological confirmation of follicular lymphoma, grade i, ii, iii according to who 2008 classification, at the time of initial diagnosis * systemic first-line treatment with immuno-chemotherapy * pet availability at the time of response after first-line treatment (optional) * clinical and radiological evidence of fl relapse or progression * histological confirmation of relapse (strongly recommended) * pet availability of at the time of relapse/progression and images available for central assessment * availability of clinical, laboratory and therapeutic treatment data at the time of initial diagnosis and relapse/progression * follow up of at least 12 months after relapse/progression exclusion criteria: * none

Keywords: follicular lymphoma fdg-pet relapse/progression
fio2 and outcomes after opcab (the carrot trial)

Conditions: Coronary Artery Disease

Summary: conventionally, a relatively high level of fraction of inspired oxygen (fio2) has been used for secure a margin of safety in patients undergoing cardiac surgery including off-pump coronary artery bypass grafting (opcab). since the potential adverse effects of hyperoxemia (via reactive oxygen species, vasocontriction, perfusion heterogeneity, myocardiac injury, etc.), various studies on this topic has been performed. however, the results are conflicting and inconsistent, and the consensus about whether the use of additional oxygen supply in cardiac surgery has not been reached among practitioners yet. this study is a multicenter study (seoul national university, asan medical center, severance hospital) where the effect of different level of fio2 on postoperative clinical outcomes is evaluated.

a sub-study will also be conducted in part of patients of the present study. in 40 out of 500 (expected) patients, two different levels of fio2 will be sequentially set with a 5-minute interval after the induction of general anesthesia. mixed venous and regional cerebral oxygen saturation will then be recorded according to the change of fio2.

Eligibility criteria:
inclusion criteria: * all patients scheduled for elective off-pump coronary artery bypass grafting exclusion criteria: * emergency * robot-assisted surgery * minimally invasive cardiac surgery requiring thoracotomy/one-lung anesthesia * preoperative pulmonary morbidity requiring oxygen therapy * preoperative use of ecmo or iabp * preoperative tracheal intubation or mechanical ventilation
trial of autologous mesenchymal stem cells in patients with multiple system atrophy

Conditions: Multiple System Atrophy

Summary: this study is based on positive results in open label trial of mesenchymal stem cells therapy in patients with multiple system atrophy (msa).


Eligibility criteria:
inclusion criteria: * 75 years old or less * multiple system atrophy * voluntary participants exclusion criteria: * doubted dementia (mmse \< 24) * severe febrile condition * serum sgot/sgpt three times above * malignant mass

Keywords: voluntary participants 75 years old or less
restricted or liberal fluid for haemodynamic resuscitation in sepsis

Conditions: Septic Shock; Fluid Resuscitation

Summary: a prospective, individual patient data meta-analysis (ipdma) of four multicentre, open-label, randomised clinical trials of initial haemodynamic resuscitation in patients with septic shock.

this study is a prospective, individual patient data meta-analysis (ipdma) of four multicentre, open-label, randomised clinical trials of initial haemodynamic resuscitation in patients with septic shock. the investigators will include four multicentre, open-label, randomised, clinical trials: * australasian resuscitation in sepsis evaluation fluids of vasopressors in emergency department sepsis (arise fluids) trial conducted in australia and new zealand. clinicaltrials.gov identifier nct04569942 * conservative versus liberal approach to fluid therapy of septic shock in intensive care (classic) trial conducted in seven european countries. clinicaltrials.gov identifier nct03668236 * crystalloid liberal or vasopressors early (clovers) trial conducted in the united states. clinicaltrials.gov identifier nct03434028 * early vasopressors in sepsis (evis) trial conducted in the united kingdom. clinicaltrials.gov identifier nct05179499 all four trials have all received relevant approval from a research ethics committee with a locally appropriate method of obtaining consent. these trials are prospectively chosen prior to the results of any individual trial being known because they are investigating the same broad question in patients with acute septic shock across several countries. the investigators of these trials collaborated to harmonise data and outcomes as far as possible across all trials to facilitate an ipdma. the aims to provide high level evidence to address the question of whether a fluid sparing/early vasopressor approach or a liberal fluid/later vasopressor approach to initial haemodynamic resuscitation in septic shock results in improved outcomes, including mortality.

Eligibility criteria:
inclusion criteria: participants of the arise fluids, classic, clovers \& evis trials who had: * suspected or proven infection * systolic blood pressure (sbp) \<100 mm hg or mean arterial pressure (map) \<65 mm hg * lactate ≥ 2.0 mmol/l * requirement for vasopressors to meet perfusion targets exclusion criteria: participants not in the arise fluids, classic, clovers \& evis trials
the south-norway atrial fibrillation screening study

Conditions: Atrial Fibrillation

Summary: atrial fibrillation (af) is the most common sustained cardiac rhythm disorder. the most serious common complication of af is ischemic stroke.the aim of this study is to investigate the yield of af screening with a continuous ecg monitor (ecg247) and to estimate the prevalence of silent af

atrial fibrillation (af) is the most common sustained cardiac rhythm disorder. the most serious common complication of af is ischemic stroke. many af cases are undiagnosed due to the asymptomatic and intermittent nature of af (silent af). today there is no simple and inexpensive method of detecting silent af and thus preventing stroke. the ecg247 sensor is a new norwegian digital clinical tool for out-of-hospital self-testing of af. the innovation project has originated from the university of agder and sorlandet hospital. the covid19 pandemic is realizing more than ever the need for single-use self-testing out-of-hospital diagnostic tools. the general aim of this open non-randomized study is to investigate the yield of af screening with a continuous ecg monitor (ecg247) and to estimate the prevalence of silent af in a cohort of 1500 65-year-old individuals with additional risk factors for stroke. if the study results indicate that easy-to-use continuous af-screening-devices designed for self-testing can identify people with previously unrecognized af, this study may contribute to change the approach to screening for af in the community. consequently, the study may prevent stroke in the future. by preventing stroke, major personal and socio-economic consequences can be avoided.

Eligibility criteria:
inclusion criteria: * age \>65 years * diabetes, heart failure, hypertension, previous stroke/tia or other cardiovascular disease (minimum 1 risk factor) * informed written consent for participation exclusion criteria: * chronic af * lack of ability to cooperate
sonographic follow-up of patients with carpal tunnel syndrome undergoing surgical or conservative treatment

Conditions: Carpal Tunnel Syndrome

Summary: in wrists with carpal tunnel syndrome (cts) the sonographically measured largest cross-sectional area (csa) of the median nerve is increased. we compared the changes in largest csa in wrists undergoing surgical decompression and wrists undergoing conservative treatment of cts.

objective: in wrists with carpal tunnel syndrome (cts) the sonographically measured largest cross-sectional area (csa) of the median nerve is increased. we compared the changes in largest csa in wrists undergoing surgical decompression and wrists undergoing conservative treatment of cts. methods: prospective cohort study in 55 consecutive patients with 78 wrists with established cts, including 60 wrists with surgical decompression and 18 wrists with conservative treatment. a sonographic examination was scheduled before and at 4 months after initiation of treatment. changes in csa between wrists with surgical and wrists with conservative treatment were compared using linear regression models.

Eligibility criteria:
inclusion criteria: * wrists with established cts exclusion criteria: * prior surgery for cts * traumatic lesions * coexistent neurological disease

Keywords: carpal tunnel syndrome median nerve ultrasonography prospective cohort study
continuous infusions vs scheduled bolus infusions

Conditions: Surgical Procedure, Unspecified; Pain, Postoperative

Summary: to compare continuous infusions to bolus infusions and there affect on post-surgical pain.

regional anesthetic techniques are an integral part to many anesthetic approaches, providing both intraoperative and postoperative anesthesia and analgesia. regional anesthesia peripheral nerve blocks have been shown to reduce postoperative pain and improve measures such as opioid requirements and readiness for discharge. by using a catheter technique for continuous peripheral nerve blocks, analgesia can be extended well into post-operative days 2 and 3, further extending these benefits. historically these catheters have implemented a continuous dosing regimen of local anesthetic, but increasingly there is evidence of improved analgesic outcomes without adverse effects by using a scheduled bolus dosing regimen. many institutions have implemented this new protocol for catheter dosing. the beneficial effect of scheduled bolus dosing has not been studied in all blocks and all surgical procedures.

Eligibility criteria:
inclusion criteria: enrollment will be offered to adult patients with asa physical status i, ii, or iii, presenting for nerve block catheters for post-operative analgesia. - exclusion criteria: exclusion criteria will include: pregnancy, incarceration, age \ 35, pre-operative opioid use \>30 mg morphine equivalents per day, inability to communicate with investigators by telephone, and pre-existing neuropathy of the operative extremity.
brain function in adolescent eating disorders and healthy peers

Conditions: Eating Disorder

Summary: this study of adolescent eating disorders (ed) will examine the association of temperament-based classifications, brain activation during incentive processing, and ed symptoms at time of scan and 1 year later to better understand the neurobiology and symptoms of ed. we will recruit 150 females currently ill with an ed and 50 controls ages 14-17 to investigate how temperaments reflecting greater inhibition, impulsivity, or effortful control correspond to 1) clinical symptoms and 2) the brain's response to anticipation and outcome of salient stimuli, and 3) by collecting follow-up clinical data one year later, identify how temperament-based subtypes predict ed symptom change (e.g., clinical prediction). data collection will rely on a technology called functional magnetic resonance imaging (fmri).


Eligibility criteria:
inclusion criteria: * female * meet dsm-v criteria for an eating disorder or never met criteria for an eating disorder * medically stable * post-pubertal (must have started menses, but subsequent loss of menses secondary to ed is fine). exclusion criteria: * psychotic illness/other mental illness requiring hospitalization * current dependence on drugs or alcohol * physical conditions known to influence eating or weight (e.g, diabetes mellitus, pregnancy). * on psychoactive medication * organic brain syndromes, delirium, psychotic disorders, or intellectual disability * neurological or medical disorders such as seizure disorder * any contraindication to undergoing an mri * major depressive disorder * left handed

Keywords: adolescents, healthy controls
the effects of red spinach extract on physical performance following chronic resistance training in trained males

Conditions: Sports

Summary: red spinach is a natural food which is a rich source of nitrates, which are beneficial in hemodynamics, cardiovascular function, and have natural hypotensive and antianginal effects . in recent research, red spinach extract has been shown to be beneficial in acute exercise performance. however, currently it is unclear how these acute increases in performance may translate to long term training adaptations. this research study is designed to measure the effects of red spinach extract (rse) on markers of physical performance, body composition, and health following chronic resistance training and anaerobic exercise.

the investigators aim to measure muscle strength, athletic performance, body composition, and muscle size in two groups of adults before and after 11 weeks of intervention in a randomized, double blinded study. one group (n=15 ) will receive an intervention of resistance exercise and a red spinach extract supplement, and the other group (n=15) will receive resistance exercise and a placebo (maltodextrin).

Eligibility criteria:
inclusion criteria: * 18-35 years old * at least 1 year of resistance training experience * are free of musculoskeletal injuries * are not taking medications that may interfere with study measurements exclusion criteria: * participant that cannot take either the rse or placebo supplement will be excluded, as this will be a double-blind study. * furthermore, participants that cannot participate in pre- and post-research testing, and/or those that cannot commit to regular training sessions will be excluded. * inability to perform physical exercise (determined by health and activity questionnaire) * taking any other nutritional supplement or performance enhancing drug. * any chronic illness that causes continuous medical care.
lung cancer diagnosis and staging using ultrasound guidance

Conditions: Lung Cancer

Summary: to collect data of all patients who have undergone endobronchial ultrasound for diagnosis or staging of suspected lung cancer

introduction: endobronchial ultrasound (ebus) is a procedure that is performed via flexible bronchoscopy under moderate sedation for visualization of lymph nodes in the chest and biopsy under real-time guidance for the staging of lung cancer or evaluation of enlarged lymph nodes. in addition, lung lesions or masses can be visualized and biopsied in the same sitting. the use of ebus has enhanced the safety and diagnostic yield of flexible bronchoscopy. aim: the data of patients with suspected lung cancer or undiagnosed lymph node enlargement in whom bronchoscopy with ebus guidance is clinically indicated will be collected prospectively. results from ebus are considered positive if a specific diagnosis is obtained ( eg malignancy) or if lymphocytes are present in the lymph node biopsy, indicating accurate sampling of lymph node. in patients with non-diagnostic ebus, the results from other procedures will be compared for analysis.

Eligibility criteria:
inclusion criteria: * patients who have undergone endobronchial ultrasound exclusion criteria: none

Keywords: endobronchial ultrasound, lung cancer
the prevalence of helicobacter pylori in shanghai, 2013 to 2019

Conditions: Peptic Ulcer; Helicobacter Pylori Infection

Summary: the study was a cross-sectional single-center study, conducted at renji hospital, shanghai jiaotong university school of medicine. we retrieved the medical records of all patients who had undergone upper gastrointestinal endoscopy from january 1, 2013 through december 31, 2019. the medical records were analyzed for the prevalence of h. pylori infection in patients with peptic ulcers.


Eligibility criteria:
inclusion criteria: all patients who had undergone upper gastrointestinal endoscopy in renji hospital because of uninvestigated dyspepsia during 2013 and 2019 were analyzed. exclusion criteria: patients that underwent upper endoscopy for reasons other than uninvestigated dyspepsia such as cirrhosis follow-up, major systemic diseases or other indications were excluded. exclusions also included absence of biopsies, unknown h. pylori status and acute ulcer bleeding.
a retrospective cohort study to develop markers for tb severity and treatment progress

Conditions: Pulmonary Tuberculoses; Tuberculosis, Pulmonary

Summary: the objective of this study is to compare how accurately the xpert mtb/rif assay ct value at diagnosis and the ai-based tuberculosis activity score predict the treatment outcome of rifampin-susceptible pulmonary tuberculosis patients. as a retrospective observational study, data from patients diagnosed with rifampin susceptible pulmonary tuberculosis through the xpert mtb/rif assay performed on sputum in 2019 at the participating institutions will be analyzed (up to 900 people).


Eligibility criteria:
inclusion criteria: * patients diagnosed with rifampin-susceptible pulmonary tuberculosis by xpert mtb/rif assay with sputum samples between january 1, 2019 and december 31, 2019 exclusion criteria: * none
elastography of the liver in cystic fibrosis patients. diagnostic and prognostic aspects

Conditions: Cystic Fibrosis; Liver Fibrosis

Summary: the aim of the study is to find cf patients at risk for cystic fibrosis related liver disease (cfld). comparison of ultrasound by two modalities and biochemical markers with histological evaluation of liver biopsy if present.

there are 209 cf patients attending stockholm cystic fibrosis center (january 2010). all up till 15 years of age are screened for liver disease annually by ultrasound (us) and also by biochemical markers. ultrasound is performed every third year over 15 years of age in patients without cfld, while all of them with diagnosed cfld are continued to be investigated annually. biochemical markers are controlled at least once every year in all cf patients. elastography of the liver will be planned together with the investigations of the annual follow up, in an optimal clinical status. if either us or elastography of the liver indicates liver disease or progress of the already existing pathological changes, a liver biopsy will be performed according to routine procedure at stockholm cf centre. also, historical data of liver biopsies and biochemical investigations will be considered in the study. elastography of the liver will be performed by fibroscan device, with transducers for children and adults, respectively. clinical importance liver us investigations in cf patients have important implications but are difficult to standardize in a routine clinical setting. elastography may have an advantage in the evaluation of early fibrosis with clinical importance in pursuing diagnostics and intensifying treatment. a significant group (up to 25 %) of cf patients may be helped by this novel method. including histological data, accuracy of elastography in cf patients may be improved. further details of the importance of fatty acid status in cf may be elucidated.

Eligibility criteria:
inclusion criteria: * verified cystic fibrosis exclusion criteria:

Keywords: cystic fibrosis elastography liver biopsy