Kornimate/medical-research-clean huggingface dataset:
a modified mathematical model to calculate power received by mechanically ventilated patients with different etiologies

Conditions: Acute Respiratory Distress Syndrome, Mechanical Ventilation, Respiratory Mechanics, Ventilator-induced Lung Injury

Summary: ventilator-induced lung injury is a common complication. the latest and most noticeable theory of its pathogenesis is called 'ergotrauma' by gattinoni in 2016. the theory uses ventilator-imposed 'energy' or 'power' to encompass several known forms of injury-inducing factors such as pressure,volume, flow, rate, etc. however, to quantify power imposed by ventilator is no easy task in clinical practice. so, gattinoni proposed a mathematical formula for easy power calculation. however, gattinoni did not compare the difference between various etiologies of acute lung injury. we will enroll 100 patients (50 with acute respiratory distress syndrome and 50 with normal lung). the ventilator-imposed power at various tidal volume (6, 8, 10 ml/kg) and positive end-expiratory pressure (5, 10 cmh2o) will be calculated by the formula. the area enclosed by hysteresis of pressure-volume curve, and hence the work it implies, will be measured as a standard. our study will aim to compare the formula in different patient groups and in taiwanese people.


Eligibility criteria:
inclusion criteria: * intubated patients aged 20 to 90 years old exclusion criteria: * fraction of inspired oxygen (fio2) higher than 60% * acute physiology and chronic health evaluation (apache) ii score more than 30 * plateau pressure or peak airway pressure more than 30 cmh2o * high risk for barotrauma * unstable hemodynamic status * under airway pressure release ventilation or high frequency oscillation ventilation therapy * under extra-corporeal membrane oxygenation support * on prone position
pulse 2-observational long-term effectiveness follow-up study of pulse 1

Conditions: Epilepsy

Summary: this is a post-market, open observational long-term effectiveness follow-up study of participants with drug-resistant epilepsy with partial-onset seizures previously enrolled in a randomized controlled trial (pulse) comparing best medical practice with or without adjunctive vagus nerve stimulation therapy.

in 2005 cyberonics, inc. initiated pulse: an open, prospective, randomized, parallel group study directly comparing best medical practice with and without adjunctive vns therapy. in july 2008, the decision was made to discontinue this study due to lower than expected enrolment, impairing the possibility to meet the primary objective with appropriate statistical power. however, the relatively large number of participants (n=121) randomized in the original pulse study offers the possibility to generate scientifically valuable and original findings if additional follow-up data can be gathered. after consultation with the pulse investigators, cyberonics decided to implement an observational long-term follow-up of the participants enrolled in the original pulse study.

Eligibility criteria:
inclusion criteria: to be eligible for the study, the participant must meet all the following criteria: 1. participant must have been randomized in the original pulse study. 2. participant must have baseline data from the original pulse study. 3. participant is able to give accurate seizure counts, health outcomes information, and complete study instruments with minimal assistance. 4. participant or legal guardian understands study procedures and has voluntarily signed an informed consent for pulse 2 in accordance with institutional and local regulatory policies. exclusion criteria: the presence of any of the following will exclude a participant from the study: 1. participant has a history of non-compliance with the completion of a seizure diary. 2. participant currently uses, or is expected to use during the study, short-wave diathermy, microwave diathermy, or therapeutic ultrasound diathermy. 3. participant is expected to require full body magnetic resonance imaging during the clinical study.

Keywords: pulse 2, drug-resistant epilepsy partial-onset seizures
influence of mask on functional capacity and quality of life during controlled endurance exercise in sedentary adults

Conditions: Sedentary Adults

Summary: subjects had randomly divided into two groups. all will do aerobic exercise in form of treadmill but group (a) will do while wearing surgical mask and group (b) without surgical mask. to detect the influence of surgical mask on functional capacity and quality of life during controlled endurance exercise in sedentary adults

group (a): 1. each subject will sign a consent form after receiving a detailed explanation about the procedure. 2. functional capacity and quality of life will be evaluated before the start of the training. 3. subjects in group a will wear surgical mask before starting of the session. 4.3 sessions will be done every week for 3 months. 5.the session will start with warming up for 5 minutes then 25 minutes of aerobic exercise on the treadmill with moderate intensity followed by cooling down for 5 minutes. 6.after finishing the program, the participant will be evaluated to detect the effect of the exercise. group (b): 1. each subject will sign a consent form after receiving a detailed explanation about the procedure. 2. functional capacity and quality of life will be evaluated before the start of the training. 3. subjects in group a will not wear any mask during the session. 4.3 sessions will be done every week for 3 months. 5.the session will start with warming up for 5 minutes then 25 minutes of aerobic exercise on the treadmill with moderate intensity followed by cooling down for 5 minutes. 6.after finishing the program, the participant will be evaluated to detect the effect of the exercise.

Eligibility criteria:
inclusion criteria: * 100 participants * 30 to 40 years of age * both sex exclusion criteria: * uncontrolled cardiopulmonary conditions, * sever un treated orthopedic condition * uncontrolled neurological conditions,) * uncontrolled diabetes, * claustrophobia, * pregnancy * recent covid-19 infection,)

Keywords: surgical mask functional capacity quality of life aerobic exercise
study on the effectiveness of af analysis software in af rhythm monitoring

Conditions: Atrial Fibrillation; Atrial Fibrillation Paroxysmal

Summary: atrial fibrillation (af) is a serious public health problem because of its increasing incidence and prevalence in the aging population. ecg is the most commonly used gold standard for clinical diagnosis of arrhythmias, but conventional ecg examinations are not adequate for long-term ecg follow-up measurements in patients with af. in this study, the af patients will wear an watch and ecg patch to continuously monitor ecg and ppg. the software uses an integrated diagnostic mechanism of "af burden + af segments" to efficiently analyze ecg and ppg data, which can quickly and accurately identify the occurrence of af and analyze af burden in real-time, facilitating physicians' diagnosis and treatment and efficacy assessment.

ppg-af study is a cohort randomized observational study.the trial will include patients with af who meet the study requirements from beijing anzhen hospital within 2 months. each participant will wear an watch and ecg monitor after admission to hospital until radiofrequency ablation for af, and after af ablation until discharge. and more than 18 hours in each period. 1. primary endpoint. the ecg and ppg data are automatically analyzed by the af analysis software. the results are compared with expert-annotated gold standard results to verify the sensitivity and specificity. 2. secondary endpoints. the af burden calculated from ppg data is compared with that from ecg monitoring, to verify the feasibility of daily monitoring of af burden using ppg analysis.

Eligibility criteria:
inclusion criteria: * be at least 18 years of age. * have clear ecg-recorded atrial fibrillation in the past and will undergo atrial fibrillation ablation in the current hospitalization. * patients who agree to wear both the watch and the ecg recorder. exclusion criteria: * inability to wear the watch due to limited mobility or other problems. * severe skin diseases such as skin allergies or skin ulcers. * chronic insomnia not treated with medication. * patients with severe cardiovascular disease who may be resuscitated at any time. * previous history of parkinson's, schizophrenia, epilepsy. * black people and those with excessively dark skin.
chronic sleep deprivation and changes in cortical and hippocampal volume

Conditions: Sleep Deprivation; Hippocampal Atrophy; Cortical Irregularity

Summary: sleep is a physiological state that is essential for human performance, including academic, occupational, interpersonal, and psychological aspects. sleep disruption or deprivation leads to a loss of psychomotor skills and an increased association with various diseases. therefore, it is critical to assess how chronic sleep deprivation affects medical residents who work long shifts, including those assigned during their training.

objective: to determine if there is an association between chronic sleep deprivation and changes in cortical and hippocampal volume, assessed by nuclear magnetic resonance, in first-year medical residents assigned to the high specialty medical unit, specialty hospital no. 1, national medical center of bajío, during a period of 2 months after their admission. materials and methods: this is a retrospective cohort study of first-year residents at umae t1, with a calculated sample size of 37 patients. results are presented using descriptive statistics with mean and standard deviation or median with confidence intervals, depending on the type of variable. the relationship between mri values and sleep deprivation will be assessed using pearson's correlation coefficient or its non-parametric equivalent. ethical considerations: the study will be conducted with the informed consent of the patients in accordance with the general health law on research and the helsinki declaration of 1975. the risk associated with this study is more than minimal. resources: magnetic resonance studies will be performed at the high specialty medical unit, specialty hospital no. 1, national medical center of bajio, under the supervision of affiliated physicians specializing in the field of radiology and a fourth year resident in diagnostic and therapeutic imaging.

Eligibility criteria:
inclusion criteria: * new resident physicians assigned to the high specialty medical unit, hospital de especialidades no. 1 centro médico nacional del bajío. exclusion criteria: * - patients who have ingested caffeine, nicotine or alcohol in the last 24 hours. * patients with sleep disorders who present a score greater than 5 in the initial assessment of the pittsburgh sleep quality index. * patients with psychiatric treatment. * patients ingesting medications that intervene in the awake state. * patients with drug abuse (marijuana, cocaine, etc.). * patients with claustrophobia. * patients with metallic implants.

Keywords: sleep deprivation hippocampal atrophy cortical irregularity first-year medical residents
a study to assess the adverse events and how oral abbv-552 capsules moves through the body of healthy adult japanese and han chinese participants

Conditions: Healthy Volunteers

Summary: this study will assess how safe abbv-552 is and how abbv-552 moves through the body of adult healthy japanese and han chinese participants. adverse events will be assessed. abbv-552 is an investigational drug being developed for potential treatment of alzheimer's disease (ad). approximately 18 adult healthy japanese and han chinese volunteers will be enrolled in 2 sites in the united states. japanese participants assigned to arm 1 will receive ascending doses of abbv-552 oral capsules once every week for 3 weeks. han chinese participants assigned to arm 2 will receive oral abbv-552 capsules on day 1. all participants will be followed for 30 days after their last dose. participants will be confined for 22 days or 8 days depending on the arm they are assigned to. adverse events and blood tests will be performed.


Eligibility criteria:
inclusion criteria: - japanese participants must be first- or second-generation japanese of full japanese parentage. first-generation participants will have been born in japan to two parents and four grandparents also born in japan of full japanese descent. second-generation participants born outside of japan must have two parents and four grandparents born in japan of full japanese descent. all participants must maintain a typical japanese lifestyle, including consuming a typical japanese diet. or * han chinese participants must be first-generation han chinese of full chinese parentage residing outside of china for less than 5 years. participants must maintain a typical chinese lifestyle, including consuming a typical chinese diet. exclusion criteria: - has no other clinically significant and/or unstable medical conditions or any other reason that the investigator determines would interfere with the participant's participation in this study or would make the participant an unsuitable candidate to receive abbv-552.

Keywords: abbv-552 alzheimer's disease (ad)
effect of nitroglycerin ointment on mastectomy flap necrosis

Conditions: Mastectomy Flap Necrosis

Summary: background: mastectomy flap necrosis (mfn) is a common complication that affects recovery, reconstructive success and aesthetic outcome. nitroglycerin (ntg) ointment is a potent topical vasodilator that increases local blood flow by dilating arteries and veins without altering the ratio of pre- to post-capillary resistance. there are no studies that evaluate whether the application of ntg ointment in patients undergoing skin-sparing mastectomy (ssm) or nipple-sparing mastectomy (nsm) and immediate reconstruction decreases the rate of mastectomy flap necrosis. objective: to evaluate if the post-operative application of ntg ointment improve rates of mfn in patients undergoing ssm or nsm with immediate breast reconstruction compared to patients receiving placebo. hypothesis: in patients undergoing ssm and immediate breast reconstruction there will be a decrease in the rate of mfn in those who receive ntg ointment compared to those who receive placebo.


Eligibility criteria:
inclusion criteria: * patients who undergo ssm or nsm with immediate alloplastic or autologous breast reconstruction * unilateral and bilateral cases (in bilateral cases only the mastectomy performed by the general surgeon will be included. this will avoid the potential effect of absorption of nitroglycerin from one breast to the other) * patients older than 21 and less than 65 exclusion criteria: * patient declining inclusion in the study * patient with medical history that precludes the administration of nitroglycerin, i.e. a medical history significant for * acute circulatory failure accompanied by clear hypotension * myocardial insufficiency related to obstruction * use of sildenafil, vardenafil \& tadalafil * use of beta-blockers, calcium channel blockers, diuretics or phenothiazides * salicylates (asa) * alteplase * recent history of mi or cardiac insufficiency * anemia, severe * cerebral hemorrhage or recent head trauma * glaucoma * hepatic function impairment, severe * hyperthyroidism * hypertrophic cardiomyopathy * hypotension * sensitivity to nitrites * patient with a history of mantle radiation * patient with an allergy to polysporin or any of its ingredients
effectiveness of aurix therapy in diabetic foot ulcers

Conditions: Diabetic Foot Ulcers

Summary: the aim of this trial is to demonstrate the effectiveness of complete wound healing in a prospective, open-label, randomized trial in which diabetic food ulcers (dfu) will be treated using aurix plus usual and customary care (ucc) and compared to a group receiving just ucc as provided in up to 100 u.s. wound centers

aurix is a platelet-rich plasma gel used in the treatment of non-healing chronic wounds. prospective observational studies of the effectiveness of aurix have demonstrated promising results in regard to the healing of dfus, including severe wagner grade 3 and 4 ulcers. the aim of this trial is to demonstrate the of complete wound healing in a prospective, open-label, randomized trial in which diabetic foot ulcers will be treated using aurix to determine the time to heal at 12 weeks. comparison will be made on a 1:1 basis of aurix + ucc versus control subjects receiving undefined ucc.

Eligibility criteria:
inclusion criteria: 1. medicare eligible 2. ≥18 years of age 3. type i or ii diabetes requiring medical treatment as determined by the physician 4. the largest non-healing wound, if multiple wounds are present, or the single wound to be treated (index ulcer) is a wagner 1-5 dfu (see appendix 9 for wagner classification) that is located on the dorsal, plantar, medial, or lateral aspect of the foot or heel (including all toe surfaces) 5. for subjects with potentially multiple eligible dfus, the largest ulcer will be selected as the index ulcer for study. there must be at least 4 cm between the index ulcer and other ulcers; if all ulcers are closer than 4 cm, the subject should not be enrolled (screen failure) 6. debrided ulcer size between 0.5 cm2 and 50 cm2 7. subject has received ucc care for ≥ 2 weeks at treating wound clinic 8. demonstrated adequate offloading regimen 9. duration ≥ 1 month at first visit 10. subject must be willing to comply with the protocol, which will be assessed by enrolling clinician. exclusion criteria: 1. subjects known to be sensitive to aurix components (calcium chloride, thrombin, ascorbic acid) and/or materials of bovine origin 2. presence of another wound that is concurrently treated and might interfere with treatment of the index wound by aurix 3. ulcer not of dfu pathophysiology (e.g., venous, vasculitic, radiation, rheumatoid, collagen vascular disease, pressure, or arterial etiology) 4. patients on chemotherapeutic agents or any malignancy in the wound area 5. subjects who are cognitively impaired 6. serum albumin of less than 2.5 g/dl 7. plasma platelet count of less than 100 x 109/l 8. hemoglobin of less than 10.5 g/dl 9. subject has inadequate venous access for repeated blood draw required for aurix administration.

Keywords: non healing wound
evaluation of a tracheostomy tube that enables communication

Conditions: Evaluate the Effect of a Talking Tracheostomy Tube on Quality of Life

Summary: verbal communication is vital to critically ill mechanically ventilated patient's quality of life (hess, 2005). patients who have a tracheostomy tube may be able to communicate using a speaking valve, however, some patients may not be able to tolerate cuff deflation for use of speaking valve. there are talking tracheostomy tubes that do not require cuff deflation to facilitate speech in this population. unfortunately, not all candidates are offered these options due to lack of awareness. recently, at our institution, there has been an increase in the use of these tubes to facilitate speech. one of the talking tracheotomy tubes that has proven to be effective is the portex blueline ultra suctionaid (blusa). in 2010, we conducted a retrospective review of 4 cases and found that blusa tracheostomy helped facilitate communication in this unique population (irb #: na_00041547). we would now like to formally conduct a prospective pilot study to evaluate the feasibility of measuring outcomes of patients with a blusa using a pretest-posttest research design. communication empowers patients and allows healthcare staff to obtain a more accurate assessment of patients' condition and tailor care accordingly. identifying the predictors of speech intelligibility and the impact of blusa on quality of life will promote communication between patients and healthcare providers. study hypothesis: determine the impact of a talking tracheostomy tube on quality of life in patients requiring prolonged mechanical ventilation in the hospital.


Eligibility criteria:
inclusion criteria: * mechanically ventilated via tracheostomy * awake, alert, and attempting to communicate * able to understand english exclusion criteria: * delirium * fresh tracheostomy within 48 hours * laryngectomy

Keywords: quality of life talking tracheostomy tube speech mechanically ventilated patients
deep transcranial magnetic stimulation in patients with alzheimer's disease

Conditions: Alzheimer's Disease

Summary: the primary objective of this trial is to assess the ability of transcranial magnetic stimulation with h2 coil to prefrontal and parieto-temporal cortex to improve cognitive performance in patients with alzheimer's disease which received drug treatment. this study is a single-center, double-blind 4 months duration trial.

primary outcome measure: adas-cog (time frame baseline, 2 months, 4 months) secondary outcome measure: cgi-c, neuropsychological computerized test (mindstream), fab,adl, beck depression inventory-time frame baseline,1 month (visit 12) 2 months (visit 16), 4 months (visit 17). estimated enrollment: 45 patients estimated study start date: november 2008 estimated study completion date: november 2012 number of arms: 3 interventions details: h2 coil device for transcranial magnetic stimulation with magstim to prefrontal and parieto-temporal regions bilaterally with frequency 10hz in one arm, 1hz in the second arm, and sham-stimulation with frequency 10hz/1hz in third arm. ages: 50-80 genders: both

Eligibility criteria:
inclusion criteria: * written informed consent will be obtained * diagnostic evidence of probable ad consistent with dsm iv * stable treatment with acetylcholine-esterase inhibitors or/and memantine for 5 weeks prior to screening * stable dose treatment with other drugs * mmse \<25 exclusion criteria: * patients with neurological or psychiatric disorders that affect cognition but are distinguishable from ad * patients who are unwilling or unable to fulfill the requirements of the study * severe personality disorder * malignant or untreated hypertension * history of epilepsy * history of head trauma * metal implant in head, cardiac pacemaker, medical pump * drug or alcohol addiction * involvement in any other clinical trial during the preceding 3 month * patient who are unwilling or unable to give informed consent

Keywords: tms ad h2 coil
syncope and implanted loop recorder: the utility of remote monitoring and patients centered setting alarms

Conditions: Syncope; Loop Recorder; Remote Monitoring

Summary: actually, there are few data about the effectiveness of remote monitoring (rm) and patient centered alarms setting in patients with unexplained syncope underwent implanted loop recorder (ilr) monitoring. the aim of this study is to evaluate the time from onset of first physician's evaluation of asyntomatic ecg events lead to medical treatment in ordinary clinical practice for syncope patients with ilr patients and compare it between patients followed with rm or conventionally with annual in-hospital visits.


Eligibility criteria:
inclusion criteria * patients with unexplained syncope underwent icm implantation according to current gudelines. exclusion criteria * patients do not provied signing patient informed consent form

Keywords: syncope loop recorder remote monitoring
internet-based stress reduction training for students

Conditions: Depression; Stress

Summary: the main objective of the current study is to evaluate whether a mindfulness based intervention delivered online can provide an effective resource for increasing psychological well-being among students. in addition, explore potential mechanisms through which the training lead to improvements by means of mediational analyses, with hypothesized variables like positive/negative affect and attention regulation.


Eligibility criteria:
inclusion criteria: * current student * have an active e-mail account * regular use of the internet exclusion criteria: * non-swedish speaking