fingerprinting of impulsivity

Conditions: Impulse Control Disorders

Summary: the study aims to examine a battery of behavioral and questionnaire measures in 4 disorders clinically associated with impulsivity and in health controls, to: 1) investigate if the different populations have a distinct behavioral profile, and 2) to investigate if there are specific measures that are reliable and sensitive measures of impulsivity across diagnoses.


Eligibility criteria:
inclusion criteria: all cohorts: - males and females ages 18-50. healthy control cohort: - volunteers in generally good psychiatric and non-psychiatric medical health borderline personality disorder (2 cohorts): - subjects who meet diagnostic and statistical manual of mental disorders-v (dsm-v) criteria for borderline personality disorder binge eating disorder cohort: - subjects who meet dsm-v criteria for binge eating disorder. stimulant use disorder cohort: - subjects who meet dsm-v criteria for current stimulant use disorder, subtype cocaine, moderate or severe use attention deficit hyperactivity disorder cohort: - subjects who meet dsm-v criteria for adult attention deficit hyperactivity disorder exclusion criteria: general: * positive breathalyzer test for alcohol at any study visit * history of clinically significant neurologic disorders or head trauma with loss of consciousness greater than 30 minutes * clinically significant non-psychiatric medical disorder requiring ongoing treatment as judged by the investigator. * unwillingness or inability to sign a written informed consent form * pregnancy as assessed by a urine test for ß-human chorionic gonadotropin (ß-hcg) at screening visit * medical or physical contraindications for participation (see below), based on medical history interview, as judged by the investigator * unwilling to refrain from tobacco use one hour prior to testing until after conclusion of testing healthy controls: * diagnostic and statistical manual of mental disorders (dsm)-5 diagnoses of personality disorders (based on structured clinical interview for dsm-iv (scid)-ii) * dsm-5 diagnoses based on the scid-i (including the eating disorders and attention deficit hyperactivity disorder (adhd) module) * history of arrest or incarceration * positive urine drug screen for cannabis, cocaine, opioids, amphetamine, and benzodiazepines at any visit * current tobacco users borderline personality disorder subjects: * dsm-5 diagnoses other than: tobacco use disorder, major depressive disorder (mild subtype), generalized anxiety disorder (in remission), post-traumatic stress disorder (in remission), major depressive disorder (moderate or severe subtype, in remission), or substance use disorder (mild subtype, in remission) * dsm-5 personality disorder other than cluster b personality disorders. * positive urine drug screen for cocaine, opioids, amphetamine, and benzodiazepines at any visit * antipsychotic medication or mood stabilizers taken within the last 30 days or change in antidepressant medication within the last 30 days. binge eating disorder subjects: * dsm-5 diagnoses other than: binge eating disorder (current bulimia also excluded), tobacco use disorder, major depressive disorder (in remission), generalized anxiety disorder (in remission), post-traumatic stress disorder (in remission), and substance use disorder (in remission, mild subtype). * dsm-5 diagnoses of cluster b personality disorders. * positive urine drug screen for cocaine, opioids, amphetamine, and benzodiazepines at any visit stimulant use disorder, cocaine subtype subjects: * dsm-5 diagnoses other than: stimulant use disorder, cannabis use disorder, alcohol use disorder (mild subtype), and tobacco use disorder, substance induced mood disorder, major depressive disorder (in remission), generalized anxiety disorder (in remission), post-traumatic stress disorder (in remission). * dsm-5 diagnoses of cluster b personality disorders. * positive urine drug screen for opioids, amphetamine, and benzodiazepines at any visit adhd subjects: * dsm-5 diagnoses other than adhd, substance induced mood disorder, major depressive disorder (in remission), generalized anxiety disorder (in remission), post-traumatic stress disorder (in remission), substance use disorder (mild subtype, in remission). * dsm-5 diagnoses of cluster b personality disorders. * stimulant medication taken the morning of behavioral testing. * positive urine drug screen for cannabis, cocaine, opioids, amphetamine, methamphetamine or benzodiazepines at any visit. subjects with a valid prescription for amphetamines for the treatment of adhd will not be excluded. * unable or unwilling to withhold medications prescribed for treatment of adhd on the morning of any behavioral testing clinic visit. * further exclusion criteria apply