Kornimate/medical-research-clean huggingface dataset:
financial incentives for increasing exercise

Conditions: Sedentary Lifestyle; Obesity

Summary: participants will be employees of genzyme who volunteer to participate in a study on motivating healthy behaviors, involving giving them goals for taking a certain number of steps per day, and increasing that number over time. participants will wear pedometers and upload their data to a website that allows them to monitor their progress, and have the opportunity to win money based on meeting their step goals. interested employees will schedule a day and time to complete a health screening at a "health fair" at their place of employment, to ensure that they are healthy enough to participate; at this time participants will also complete the investigators baseline dependent measures, and receive a pedometer. after a one-week baseline period during which they wear the pedometer and the investigators establish their typical number of steps per day, eligible participants will then be assigned to one of four treatments - a "no incentive" control condition, and three conditions in which they are entered into different kinds of monetary lotteries if they have met their step goals for that day. participants' initial goal will be based on their steps during the baseline period, and the goal will increase by 250 steps each week, for a total of 12 weeks. after these 3 months, the incentives portion of the experiment ends, but participants continue to wear their pedometers and upload their data for an additional 6 months. at 3 months, 6 months, and then at the study end at 9 months, participants again complete the investigators dependent measures at follow-up health fairs at their place of employment.


Eligibility criteria:
inclusion criteria: * bmi of 28 or higher * pass the par-q * answer "no" to all par-q questions * at least 18 years of age * has computer at home or work with compatible operating system (i.e. windows 2000, windows xp, windows vista, osx 10.3-10.5), internet access, and usb port exclusion criteria: * anyone who does not meet all of the inclusion criteria

Keywords: sedentary lifestyle physical exercise behavioral economics financial incentives obesity
trial on the effect of media multi-tasking on attention to food cues and cued overeating

Conditions: Attention Concentration Difficulty; Obesity, Childhood

Summary: childhood obesity is a critical public health problem in the united states. one factor known to contribute to childhood obesity is excess consumption. importantly, excess consumption related to weight gain is not necessarily driven by hunger. for example, environmental food cues stimulate brain reward regions and lead to overeating even after a child has eaten to satiety. this type of cued eating is associated with increased attention to food cues; the amount of time a child spends looking at food cues (e.g., food advertisements) is associated with increased caloric intake. however, individual susceptibility to environmental food cues remains unknown. it is proposed that the prevalent practice of media multi-tasking-simultaneously attending to multiple electronic media sources-increases attention to peripheral food cues in the environment and thereby plays an important role in the development of obesity. it is hypothesized that multi-tasking teaches children to engage in constant task switching that makes them more responsive to peripheral cues, many of which are potentially harmful (such as those that promote overeating). the overarching hypothesis is that media multi-tasking alters the attentional networks of the brain that control attention to environmental cues. high media multi-tasking children are therefore particularly susceptible to food cues, thereby leading to increased cued eating. it is also predicted that attention modification training can provide a protective effect against detrimental attentional processing caused multi-tasking, by increasing the proficiency of the attention networks. these hypotheses will be tested by assessing the pathway between media-multitasking, attention to food cues, and cued eating. it will also be examined whether it is possible to intervene on this pathway by piloting an at-home attention modification training intervention designed to reduce attention to food cues. it is our belief that this research will lead to the development of low-cost, scalable tools that can train attention networks so that children are less influenced by peripheral food cues, a known cause of overeating. for example, having children practice attention modification intervention tasks regularly (which could be accomplished through user-friendly computer games or cell phone/tablet apps) might offset the negative attentional effects of media multi-tasking.

\[3/14/2020\]: study recruitment temporarily halted due to the covid-19 pandemic

Eligibility criteria:
inclusion criteria: * n/a. exclusion criteria: * inadequate english proficiency, a vision disorder that is not corrected with corrective lenses, and relevant food allergies.

Keywords: attention food cues media multi-tasking
a study to determine the safety and efficacy of an ultrasound device in the management of acute acne lesions

Conditions: Acne Vulgaris

Summary: the purpose of this study is to find out how effective and safe an experimental ultrasound device is for treating acute acne lesions.

acne vulgaris is a disease that occurs when oil and dead skin cells clog the pores of the skin. when the skin's pores are clogged, red spots and bumps known as pimples are formed, usually on the face, neck, chest, and back. in adolescents and adults, acne vulgaris is commonly called "acne." many factors have been associated with acne. one of the factors is the increased production of fatty substances from an enlarged sebaceous gland ("oil gland"). the experimental ultrasonic device uses sound waves (called ultrasonic waves) to heat the acute acne lesion and the surrounding sebaceous ("oil") glands deep in the skin without affecting the surface of the skin. we hope that heating the sebaceous glands will reduce their size and reduce the symptoms of inflamed acne. using ultrasonic waves to treat acne is investigational. this is a pilot study. a pilot study is done on a small group of subjects to learn if the device will be effective and safe, before the device is used on a larger group of subjects.

Eligibility criteria:
inclusion criteria: * female or male subjects, * greater than 18 years age, * with acute acne on the face. exclusion criteria: * pregnancy, * concomitant skin diseases, * severe acne, * antibiotic therapy.
trapezius muscle activities in the natural head posture and corrected head posture during wall-slide exercise

Conditions: Trapezius Muscle Atrophy

Summary: the goal of this observational study is to investigate the effect of head posture on trapezius muscle activity and ratios during wall slide exercise. the main question the study aims to answer is: •how does the trapezius muscle activity change during wall slide exercise when performed with a natural head posture and the corrected head posture? the participants performed wall slide exercise with their natural head posture and the corrected posture. for both interventions, muscle activity of the lower, middle and upper trapezius was measured with surface electromyography(emg) noraxon minidts system (noraxon, usa, inc, scottsdale, az) in the ascending, stationary and descending phases of the exercise.

healthy individuals between the ages of 18 and 35 who have not had any pain in the upper extremity for the last 6 weeks, have musculoskeletal system pathologies of the upper extremity and/or any surgery were included in the study. individuals who have had pain in the shoulder area for the last 6 weeks, had shoulder injury and/or shoulder surgery, have neurological, rheumatological or systemic diseases and body mass index (bmi) greater than 30 kg/m2 were excluded. participants were asked to perform wall-slide exercise with both natural head posture and corrected head posture, separately. during the wall-slide exercise, muscle activations of upper trapezius (ut), middle trapezius (mt) and lower trapezius (lt) were measured with surface emg noraxon minidts system (noraxon, usa, inc, scottsdale, az) in the ascending, stationary and descending phases of the exercise.

Eligibility criteria:
inclusion criteria: * healthy individuals between the ages of 18 and 35 * individuals who have not had any pain in the upper extremity for the last 6 weeks * individuals who do not have musculoskeletal system pathologies of the upper extremity and/or any surgery exclusion criteria: * individuals who have had pain in the shoulder area for the last 6 weeks * individuals who had shoulder injury and/or shoulder surgery * individuals who have neurological, rheumatological or systemic diseases * individuals with body mass index (bmi) greater than 30 kg/m2
acs registry - a non-interventional study to estimate the rates of outcomes in acs patients in moscow

Conditions: Heart Attack; Stroke; Cardiovascular Death

Summary: cardiovascular diseases (cvd) are currently the leading cause of death in industrialized countries and are expected to become the leading cause of death in emerging countries by 20201. according to the official russian statistics, in 2015, cvd was the cause in 34% of deaths in russia2. acute coronary syndrome (acs) is the most prevalent manifestation of cvd and is associated with high mortality and morbidity. no other life-threatening disease is as prevalent or expensive to society3. in 2014 in russian federation 46 250 people died from acute myocardial infarction (mi) and 17 605 people died from recurrent mi4. acs is a clinical syndrome characterized by unstable angina (ua), non-st-segment elevation myocardial infarction (nstemi) and st-segment elevation myocardial infarction (stemi). the most common cause of acs is reduced myocardial perfusion that results from coronary artery narrowing caused by the formation of partially or totally occlusive thrombi in response to rupture of atherosclerotic plaques on the vessel wall5-7. in russian federation acs management after acs is provided in out-patient settings by doctors of different specialties (cardiologists and general practitioners (gps)). however, the management of acs in out-patient settings in some regions in russian federation is frequently suboptimal. moscow city significantly differs from other parts of russia from acs management at hospital stage (up to 90% of pci managed st elevation myocardial infarction (mi) patients, no thrombolysis, short first medical contact to balloon time etc.) but it is unclear if management of post mi patients in moscow out-patient settings is also optimal. in-hospital mortality in mi patients decreased last years but there is no data on clinical outcomes during 12 months after mi in moscow. this study will provide the epidemiological data about rates of major adverse cardiovascular and cerebrovascular events (macce) (mi, stroke, cardiovascular death) within 12 months after mi in real clinical practice in moscow and describe dapt at out-patient setting. the information received in this study will help to optimize management of russian patients with acs. the data will be used in discussion with payers


Eligibility criteria:
inclusion criteria: the subject population that will be observed in this prospective study must meet the following criteria: 1. patients survivors who visited outpatient setting after discharge from hospital due to mi (stemi or nstemi) within 1 month after discharge from hospital; 2. obtained written informed consent for participation in this study. 3. age of 18 year or older. exclusion criteria: 1. current participation in a clinical study. 2. unknown type of mi
improving outcomes for individuals with serious mental illness and diabetes

Conditions: Diabetes Mellitus; Bipolar Disorder; Depression; Psychotic Disorders; Schizophrenia

Summary: this project tests a model for improving illness self-management among persons who have both serious mental illness and diabetes and will be performed within a primary care setting at a safety net hospital system. the information gained from the randomized trial will be supplemented with reports from participants about their experiences of trying to improve illness self-management. improvements in self-management should result in a reduction of psychiatric symptoms and improvements in functioning and physical health.

this project will test a novel intervention, targeted training in illness management (ttim), intended to improve both serious mental illness (smi) and diabetes mellitus (dm) self-management in 100 individuals with smi-dm vs. 100 individuals with smi-dm receiving treatment as usual (tau). the intervention will be conducted in a safety-net health system primary care setting and will be conducted as a randomized controlled trial (rct). the primary effects of ttim will be assessed with respect to smi symptoms, functional status/role impairment, general health status, and dm outcomes. secondary outcomes include adherence to psychotropic and dm medication, and engagement in healthy behaviors. this assessment will include quantitative assessment of facilitators/barriers targeted by the proposed intervention as well as a supplemental qualitative assessment. the qualitative assessments will include input from patients and interventionists. specific aims for the qualitative analysis are to validate findings from the rct, expand understanding of "key active ingredients" of ttim, and provide information to inform future studies on individuals with smi and related medical conditions.

Eligibility criteria:
inclusion criteria: 1. have diagnostic and statistical manual of mental disorders, fourth edition (dsm-iv) diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder or major depression 2. have dm based upon either previous diagnosis or laboratory values 3. be ≥ 18 years of age 4. be able to communicate in english 5. be able to provide written, informed consent to participation. exclusion criteria: 1. actively suicidal/homicidal 2. unable to be rated on study rating scales 3. demented 4. pregnant 5. unable to provide informed consent.

Keywords: serious mental illness diabetes
study of an implantable device for lowering intraocular pressure in glaucoma patients undergoing cataract surgery

Conditions: Primary Open Angle Glaucoma (POAG); Cataract

Summary: the purpose of this study is to evaluate the safety and efficacy of the cypass implant for lowering intraocular pressure (iop) in patients with glaucoma who undergo cataract surgery.

this study is a modified and expanded protocol based on acceptable safety results from an earlier feasibility study. the trial is conducted using a 3:1 randomization (treatment to control) in which patients are screened for eligibility, randomized at time of surgery and followed for 24 months postoperatively.

Eligibility criteria:
preoperative inclusion criteria: * diagnosis of primary open angle glaucoma (poag) * mean diurnal unmedicated iop of 21 - 33 mmhg * normal anterior chamber angle anatomy at site of implantation * operable age-related cataract exclusion criteria: * use of more than 3 ocular hypotensive medications (combination medications count as 2 medications) * significant risk associated with washout of ocular hypotensive medication * previous glaucoma surgery (with exception of laser treatments to the trabecular meshwork) * previous corneal surgery * clinically significant ocular pathology, other than cataract and glaucoma * diagnosis of acute angle closure, traumatic, congenital, malignant, uveitic, pseudoexfoliative, pigmentary or neovascular glaucoma

Keywords: glaucoma glaucoma device glaucoma surgery intraocular pressure
study to evaluate the effectiveness of rotarix™ against severe gastroenteritis among hospitalized children in brazil

Conditions: Rotavirus Gastroenteritis

Summary: the purpose of this study is to estimate the effectiveness of 2 doses of rotarix™ vaccination in preventing rotavirus severe gastroenteritis among children hospitalized in belem area, brazil.

the study will be comprised of two parts: case-control study and rotavirus strain surveillance.

Eligibility criteria:
inclusion criteria: for cases: * a male or female child born after 6 march 2006 and at least 12 weeks of age. * subject admitted to the study clinics/hospitals for severe gastroenteritis during the study period. * onset of severe gastroenteritis ≤ 14 days prior to admission. * laboratory confirmed rotavirus positive stool sample at hospital admission or during the first 48 hours of hospitalization. * written informed consent obtained from the parent or guardian of the subject. for controls: * admitted for non-gastroenteritis causes at the same clinic/hospital as the case. * living in the same neighbourhood as the case for at least three consecutive months without any symptoms of gastroenteritis or severe gastroenteritis on the day of interview of his/ her parents/ guardians. * being born within +- 2 weeks from the date of birth of the case. if the number required is not available, then the range would be extended to +- 4 weeks, and ultimately up to +- 6 weeks for hospital controls. for neighbourhood controls, the range may be extended to +- 8 weeks. * written informed consent obtained from the parent or guardian of the child. exclusion criteria: for cases: * subject has previously participated as case or control in this study. * onset of severe gastroenteritis \> 48 hours after admission to the hospital (nosocomial infections). for controls: * for hospital controls: child who has symptoms of gastroenteritis during current hospitalization or on the day of interview of his/her parent or guardian or for neighbourhood controls: child who has symptoms of gastroenteritis or severe gastroenteritis on the day of interview of his/her parent or guardian. * exclude children with the following vaccine preventable diseases: measles, mumps, rubella, diphtheria, pertussis, tetanus, tuberculosis, invasive haemophilus influenzae type b (hib) infections (meningitis, bacteraemia, septic arthritis, cellulitis, and epiglottitis) and hepatitis b. * child has participated in the past as a case or control in this study. * child living in the same house as the case
comparison of the effect of remimazolam and propofol on perioperative hypothermia under spinal anesthesia

Conditions: Lower Extremity Problem; Gynecologic Disease; Urinary Tract Disease

Summary: after dividing the patients into two groups, sedation is performed with propofol and remimazolam, respectively, after spinal anesthesia. compare the patient's body temperature change after surgery.

patients in the study were randomly assigned to the propofol group (group p) and the remimazolam group (group r) in a 1:1 ratio. study drugs are prepared in the same 50 ml syringe, double-blind to group assignment. all patients are not given pre-anesthetic medication, and body temperature, blood pressure, and heart rate are measured in the recovery room after surgery at 10-minute intervals from just before anesthesia induction to surgery. if hypotension or bradycardia occurs during surgery and is not corrected even after rapid fluid infusion, ephedrine is increased by 10 mg or glycopyrrolate 0.2 mg or atropine 0.5 mg is administered. if spinal anesthesia is successfully performed, check the patient's anesthesia height. when the appropriate level of anesthesia is confirmed, group p receives propofol at 25-100ug/kg/min and maintains the bis at 70-80. group r receives remimazolam at 1-20ug/kg/min and maintains bis between 70-80. both groups apply a conventionally used air heating device, and the operating room temperature is kept at 20 °c. if shivering occurs during surgery, the elapsed time from induction and the shivering grades are recorded. at the end of the surgery, record total anesthesia time and surgery time, fluid dose, and drug use. after moving to the recovery room, the patient's body temperature, systolic blood pressure, diastolic pressure, heart rate, the incidence of shivering, and the grade of shivering are checked. when shivering occurs, a forced air-warming device is applied first, and if shivering continues, administer meperidine in 5mg increments until the patient is comfortable and record the total dose.

Eligibility criteria:
inclusion criteria: * those aged between 19 and under 65 who are undergoing surgery under spinal anesthesia at wonkwang university hospital. * american society of anesthesiologists' physical status class (asa) award class i-iii. exclusion criteria: * patients with fever before surgery * patients taking antipyretics before surgery * patients who are chronically using anti-inflammatory drugs * high-risk patients with asa class iv or higher * patient who refused sedation * patients with thyroid dysfunction.
treatment of trigger finger with steroid injection versus steroid injection and splinting

Conditions: Trigger Finger; Stenosing Tenosynovitis

Summary: hypothesis: treatment of trigger finger by corticosteroid injection and splinting is superior to corticosteroid treatment alone.

stenosing tenosynovitis, or more commonly "trigger finger" is a disease that can severely impact a patient's quality of life. its incidence is said to be 28 persons per 100,000 annually. the disease is manifested in one or more fingers by finger locking in flexion or extension, leading to pain, discomfort and at times, loss of function. patients frequently report having to snap their fingers back in position to alleviate symptoms. the pathophysiology relates to thickening of the flexor tendon sheath, which can impair tendon gliding within it. although multiple treatment strategies are available, it is not entirely clear which treatment offers the best outcome, especially when the finger has not reached end stage locking. in general, corticosteroid injection into the tendon sheath is offered as the first line of treatment. splinting alone has also been described as a reliable method treatment. however, patel and bassini indicated that steroid injection results in fewer recurrences than splinting alone. surgery is typically reserved for recurrent triggering, cases refractory to injection, or digits locked in flexion. the effects of steroid injection followed by splinting however have not been reported in a comprehensive fashion. it may be that this form of treatment could result in a synergistic effect, which can offer a treatment modality superior to either injection or splinting alone. the purpose of this research study is to determine whether steroid injection followed by splinting is superior to injection alone.

Eligibility criteria:
inclusion criteria: * trigger finger in one or more trigger fingers, in stages 2 to 5 (inclusive) * adult patient aged over 18 years. * no prior treatment (splinting, injection or surgery) to the involved finger or at least 1 year since last treatment of the involved finger. exclusion criteria: * exclude trigger thumbs because they appear to be respond very favorably or unfavorably to treatment3 * exclude locked digits because surgery is indicated in these cases * pregnant patients * prisoners * patients with impaired decision-making capacity * patients that do not speak english and cannot fill in english language questionnaires.

Keywords: trigger finger orthotic intervention