Kornimate/medical-research-clean huggingface dataset:
obesity and psychotherapy as an alternative to treatment

Conditions: Obesity; Therapy

Summary: adherence to obesity treatment programs has been a limiting factor to good results in loosing weight. this study aimed to verify if obese subjects submitted to a physical exercise program and group psychotherapy would have a greater adherence, than obese people exercising only.

the sample was forty people, both genders, mean age: 42,2 ± 10,7 years old. physical exercise consisted of walking and stretching three times a week, during 50 minutes, with intensity verified by the borg scale, during three months. one of the days were supervised by the authors while two were freely chosen by the participant, without supervision. the verified variables were: total body mass, height, body mass index, physical activity level, caloric expenditure, waist circumference and fat percentile. half of the sample participated of group psychotherapy once weekly.

Eligibility criteria:
inclusion criteria: * bmi \>= 30 kg/m2 exclusion criteria: * age less than 25 or more than 62

Keywords: obesity exercise psychotherapy
real-time videoconference-based exercise in eldercare workers

Conditions: Pain; Mental Disorders

Summary: formal caregiving of elderly dependent people is a both physically and psychologically demanding job, and both musculoskeletal and mental disorders with a negative impact in general health and quality of life are habitual among eldercare workers. previous research has shown that physical exercise programs can reduce and/or prevent those disorders, consequently improving well-being at work. online exercise interventions might be a cost-effective tool, as they can reach a large number of people at a relatively low cost. moreover, they are compatible with situations in which interpersonal physical distancing is required, such as the current covid-19 pandemic. however, real-time videoconference-based exercise interventions have not yet been studied in working populations. thus, the aim of this study is to assess the effects of a real-time videoconference-based exercise intervention in eldercare workers. the primary outcome will be low back pain. pain in neck, shoulders and wrists/hands will also be recorded, as well as additional measures of physical fitness, psychoaffective state, health and work-related variables. all outcomes will be measured at baseline and at 12-week and 48-week follow-ups.


Eligibility criteria:
inclusion criteria: * professional eldercare workers with ≥3 months of experience in the profession * employment contract at least until the anticipated date of study end exclusion criteria: * pregnancy * contraindication to exercise according to the american college of sports medicine guidelines

Keywords: eldercare caregiver exercise tele-health musculoskeletal disorders mental disorders absenteeism work ability work performance
sub-vastus versus mid-vastus arthrotomy for total knee arthroplasty: a randomized clinical trial

Conditions: Tricompartmental Gonarthrosis

Summary: randomized, single-blind trial in which one group of patients will be operated with a "mid-vastus approach" of the knee joint and the other group will undergo knee surgery with a "sub-vastus approach".


Eligibility criteria:
inclusion criteria: * patients diagnosed with osteoarthrosis of the knee * patients must be in good general health condition exclusion criteria: * patients with morbid obesity (bmi \>45) * patients with history of knee surgery, infection or inflammatory disease of the knee joint or large cartilage lesion
communityrx-cardiovascular disease

Conditions: Cardiovascular Diseases; Self Efficacy

Summary: the goal of this single arm pre-test post-test design study is to test the impact of providing patients with information about community-based resources to address health-related social needs and cardiometabolic health in rural african american patients. the main question it aims to answer is: • what is the effectiveness of community resource information on patient self-efficacy to use community resources? participants will be given: * a personalized "healtherx" resource with information about community resources related to food, housing, utility support, transportation, and crisis support. the healtherx is personalized for patients based on their age and zip code. * access to a community resource navigator for support with using the healtherx upon request * 2 text messages with reminders about the healtherx and access to the community resource navigator


Eligibility criteria:
inclusion criteria: * patient * african american * age 2 or older * have at least one cardiometabolic condition: * overweight (bmi greater than or equal to 25 kg/m\^2); * obesity (bmi greater than or equal to 30 kg/m\^2); * icd-9 or 10 diagnostic code for overweight or obesity * adult prehypertension (sbp 120 to 129 and dbp greater than 80 mmhg); * adult hypertension (sbp greater than or equal to130 or dbp = 80 mmhg); * pediatric prehypertension (sbp or dbp greater than or equal to 90th but \<95th percentile) * pediatric hypertension (sbp or dbp greater than or equal to 95th percentile); * icd-9 or 10 diagnostic code for hypertension * adult and pediatric prediabetes (fasting glucose 100-125 mg/dl or ogtt 140-199 mg/dl) * adult and pediatric diabetes (fpg greater than or equal to126 mg/dl (7.0 mmol/l) or ogtt greater than or equal to 200 mg/dl (11.1mmol/l) or hgba1c greater than or equal to 6.5); * icd-9 or 10 diagnostic code for diabetes, pre-diabetes or elevated glucose, or gestational diabetes; * adult and pediatric total cholesterol (\>200mg/dl; ldl \>130mg/dl; hdl \< 35 mg/dl; tg greater than or equal to150mg/dl); * icd-9 or 10 diagnostic code for hyperlipidemia exclusion criteria: * unable to read, speak or understand english * unable to receive text message or email communications * living in the same household as someone already enrolled in the crx-cvd study * adults with limited life expectancy (e.g., advanced cancer, end stage liver disease, hospice) * adults receiving treatment for cancer * adults living in skilled nursing facilities * dementia/other significant cognitive impairment

Keywords: cardiovascular disease social determinants of health rural health health related social needs self efficacy
transition of diabetes care from pediatric to adult healthcare providers.

Conditions: Transition

Summary: a dedicated pre-transition class, as proposed in this study, could help facilitate a smooth transition between pediatric and adult diabetes care. the innovation in this study is that these classes are an opportunity for the patients and their families to meet with the adult diabetes team consisting of a diabetologist, rd and cde, prior to the transition of care. having met them would then increase the likelihood of compliance with the adult clinic visits.


Eligibility criteria:
inclusion criteria: adolescents with type 1 diabetes exclusion criteria: not wanting to participate in the classes
clinical monitoring, mri and neuro-ophthalmology of a cohort of patients with a clinically isolated syndrome (cis)

Conditions: Clinically Isolated Syndrome; Multiple Sclerosis

Summary: the purpose of this study is to develop tools to detect, measure, monitor and predict axonal damage in the course of cis and during multiple sclerosis (ms), in order to be able to consider as early as possible an adaptation of the background treatment in patients with ms. patients with radiological criteria of poor long-term clinical course.


Eligibility criteria:
inclusion criteria: * any patient who has had a cis of less than 4 months (+/- 15 days), with at least 1 inflammatory lesion on his initial brain mri or with normal brain mri associated with the presence of oligoclonal bands in the csf, exclusion criteria: * atypical cis for a first relapse of multiple sclerosis (extensive myelitis, bilateral retrobulbar optic neuritis immediately) * cis dating more than 4 months (+/- 15 days) * corticotherapy in the last 4 weeks
open-label, randomized study evaluating treatment with venlafaxine extended-release plus dialogues time to talk program

Conditions: Depressive Disorder, Major

Summary: the purpose of this study is to evaluate the effect of the dialogues time to talk program in subjects treated with venlafaxine extended release (er). dialogues time to talk program is a patient management program, which aims to help patients achieve successful outcomes by reinforcing physician treatment efforts, providing feedback to treating physicians, and encouraging better physician-patient communications.


Eligibility criteria:
inclusion criteria: * currently experiencing a major depressive episode, which requires the initiation of antidepressant drug treatment or a change in current antidepressant drug treatment * at least 18 years of age exclusion criteria: * history or presence of bipolar disorder * current treatment with venlafaxine

Keywords: major depressive disorder depression anxiety
effectiveness of proprioceptive exercises program in patients with carpometacarpal joint osteoarthritis

Conditions: Thumb Osteoarthritis

Summary: objective: to establish the effectiveness of a proprioceptive training program as a complementary therapy for a traditional protocol in position control, pain intensity, upper limb function and occupation performance for patients with thumb cmc joint oa. methods: standard conservative thumb cmc joint oa treatments were received for both the control (n=26) and experimental groups (n=26) for a period of 12 weeks. the experimental group received a proprioceptive training program during the same intervention period, which was conducted twice weekly (24 sessions). the severity of pain with activity was measured according to the visual analog scale (vas). quickdash questionnaire was used to measure upper extremity function. patient's occupational performance was measured with the canadian occupational performance measure (copm) and proprioception was assessed using joint position sense (jps) testing.


Eligibility criteria:
inclusion criteria: patients were included if they satisfied the following inclusion criteria; over 18 years of age with a diagnosis of grade i, ii or iii thumb cmc joint oa in their dominant hand according to the eaton classification stage (14), a minimum pain rating of 4/10 on the visual analogue scale (vas) during activities of daily living (adls) at the time of the therapy initial evaluation,and the ability to read and understand the patient information sheets and exercises. exclusion criteria: patients were excluded from participation if they had a neurological disorder affecting the upper limb, had received specific treatment for hand or thumb pain in the same limb in the last 6 months including an intra-articular joint injection to wrist, fingers, or thumb, had fractures or a significant hand injury or previous surgery to the wrist or hand, or had hand or finger tenosynovitis and/or dupuytren disease. we also excluded patients with cognitive impairments who were not able to understand the informed consent and/or exercise program.

Keywords: thumb pain thumb proprioception thumb osteoarthritis
use of device data to predict frailty in individuals

Conditions: Age Problem; Morality; Arrhythmias, Cardiac

Summary: this is an investigation to examine the correlation and predictive ability of activity measures obtained from cardiovascular implantable electrical devices.

technology is providing new opportunities to gain insight into patient health in a manner far superior to what can be obtained from routine office visits. for geriatric patients, frailty is one such measure, which has been shown to have a negative correlation with outcomes, including hospitalizations, complications following invasive procedures, and overall mortality. methods to quantify frailty have been highly limited and somewhat controversial, largely because of their cross-sectional nature. efforts to obtain longitudinal measures of frailty using activity monitors and other wearable devices have been promising, although they are limited by patient cooperation and cost. in addition to their therapeutic functions, cardiovascular implantable electrical devices (cieds) collect large amounts of data on individuals in whom they are implanted, which can be accessed during office visits as well as remotely. importantly, the data is obtained passively and routinely from all patients, requiring little to no additional effort or expense. the possibility that activity measures from cieds could be used to evaluate frailty, as well as other outcomes, would provide a powerful tool for clinicians to apply data science directly to patients. this pilot investigation will assess the feasibility of using cied-derived activity data to predict frailty, and other outcomes, in older populations. the investigators plan to enroll subjects in whom cieds are implanted from the university of colorado hospital device clinic, and analyze their data to assess the correlation of daily activity with frailty measures, as well as with cardiac and clinical outcomes.

Eligibility criteria:
inclusion criteria: * individuals followed in the uch device clinic * individuals with cied implanted * age over 65 exclusion criteria: * unable/unwilling to provide informed consent
study of licarbazepine in the treatment of manic episodes of bipolar disorder

Conditions: Bipolar Disorder

Summary: the purpose of this study is to evaluate the effectiveness and tolerability of an investigational drug for the treatment of manic episodes of bipolar disorder. the investigational drug will be given as additional treatment with either lithium or valproate, which are already fda (food and drug administration)-approved treatments for mania.


Eligibility criteria:
inclusion criteria: * diagnosis of bipolar disorder (type i) with manic or mixed episodes (including patients with/without psychotic features or with/without a history of rapid cycling) * in need of psychiatric treatment * cooperation and willingness to complete all aspects of the study exclusion criteria: * current diagnosis other than bipolar i disorder * history of schizophrenia or schizoaffective disorder * drug dependence within 1 month prior to study start or testing positive in a urine drug test * suicide attempt within 1 month prior to study start or at immediate risk of harm to self or others * any form of psychotherapy within 1 month prior to study start

Keywords: bipolar disorder manic episode treatment licarbazepine
inhaled iloprost for the treatment of persistent pulmonary hypertension in the term and near term infants.

Conditions: Pulmonary Hypertension

Summary: inhaled iloprost will be administered to near term infants with persistent pulmonary hypertension of the newborn in two different doses in order to test safety and efficacy in reducing pulmonary artery pressure.

infants eligible for the study will be divided into two arms according to oxygenation index: infants in arm a (oi \ 20) will receive no, and in addition will receive nebulized iloprost in a lower dose for one hour and a higher dose for another hour.

Eligibility criteria:
inclusion criteria: * near-term infants (\>34 gestational age) with evidence of persistent pulmonary hypertension and severe hypoxia(pao2\<100 mmhg with mechanical ventilation with fio2=100%). exclusion criteria: * major congenital malformation * congenital diaphragmatic hernia * structural cardiac anomalies * hydrops fetalis * pulmonary hemorrhage * severe perinatal depression * patients on high frequency oscillation ventilator

Keywords: iloprost pphn newborn pulmonary hypertension term persistent pulmonary hypertension of the newborn
leptin signaling in lean and obese humans

Conditions: Obesity

Summary: obesity does not respond to high circulating levels of the hormone leptin. this study is aiming at finding out why this happens and open new avenues for treatment of obesity.

ex vivo and in vitro identification and study of leptin signaling pathways in commercially available cell lines serum/ plasma samples and discarded tissues from humans.

Eligibility criteria:
inclusion criteria: * men and women * ages 18 to 65 * bmi ranges between 20 and 45 kg/m2 exclusion criteria: * subjects requiring special diets * history of illness other than obesity of diabetes * taking medications known to influence glucose metabolism * subjects with history of anaphylactic reaction or hypersensitivity to e. coli derived proteins or anesthetic agents * women who are breastfeeding, pregnant or wanting to become pregnant * subjects with bleeding dyscrasia or poor wound healing
ultrasonography assessment of peripheral entheses in axial spondyloarthritis and in healthy subjects, athletes or not

Conditions: Peripheral Entheses

Summary: purpose: * assessment of ultrasound masei index in axial spondyloarthritis and in healthy subjects, athletes or not * comparison of the ultrasound semiology of enthesitis in the 3 populations * comparison of the masei scores in the 3 populations


Eligibility criteria:
inclusion criteria: * - axial spondyloarthritis according to the asas classification criteria * 18-45 years old * athletes are defined by sport activities greater than or equal to 6 hours per week * non athletes are defined by sport activities lesser than or equal to 1 hour per week exclusion criteria: * - history of heel or ankle surgery * recent corticosteroid infiltration of the heel or the ankle
telocytes in placental tissues of patients with gestational and pre-gestational diabetes

Conditions: Diabetes in Pregnancy

Summary: examining the expression of telocytes in the placental tissues and umbilical cord of patients with gestational or pregestational diabetes during pregnancy compared to control.

this is an observational study, patients with gestational or pre-gestational diabetes undergoing elective (pre-labour) cesarean section will be asked to participate in the study. samples of placenta and umbilical cord will be taken postpartum and will be fixed and examined using immunohistochemistry to measure abundance of telocytes in these tissues. another group of patients with non complicated pregnancies will be asked to join as a control. as the topic was never studied before, a pilot phase of 10 patients per group will be done followed by sample size collection based on sd of number of telocytes in each group. diabetes patients will divided in 3 subgroups; gestational diabetes and pre-gestational diabetes type 1 or 2. each group will be further subdivided according to hba1c level collected at the time of delivery into controlled or non controlled.

Eligibility criteria:
inclusion criteria: * all pregnant women presented at the delivery ward in sohag university hospital, sohag, egypt with the following criteria: 1. study group: singleton pregnancies complicated with diabetes undergoing pre-labour cs at gestational age (37+0 to 40+0). these will be divided into 3 groups according to the type of disease either gestational diabetes (group a), pregestational diabetes type 1 (group b) or type 2 (group c). 2-control group: singleton pregnancies undergoing elective pre-labour cs at gestational age (37+0 to 40+0) that are otherwise healthy exclusion criteria: * women with history of medical co-morbidities other than diabetes are excluded from the study. this includes the following: chronic hypertension, renal diseases, autoimmune diseases, history of organ transplantation and immunosuppressive therapy, hematological diseases, history of thrombotic events, cardiopulmonary diseases, liver diseases acute and chronic inflammatory diseases. * pregnancy induced medical disorders like: gestational hypertension, preeclampsia, gestational thrombocytopenia, and proteinuria. * multiple pregnancies. * abnormal placentation, i.e. placenta previa and morbidly adherent placenta. * fetal anomalies. * vaginal deliveries and cs in labor. * spontaneous delivery.

Keywords: pregnancy diabetes telocytes placenta umbilical cord
the 10/7 hiit shock cycle study: effectiveness of 10 hiit sessions in 7 days

Conditions: Healthy; Athlete; Performance

Summary: a randomized, controlled trial to evaluate the effects of two versions of 10 high intensity interval trainings (hiit) within a 7-day shock microcycle on endurance performance, well-being, health, stress and recovery in trained athletes.

thirty-six trained endurance athletes will be recruited and randomly assigned to either a "high volume (hiit-hv)" group, a "low volume (hiit-lv)" group, or a control group. all participants will be monitored before (9 days), during (7 days), and after (14 days) a 7-day training intervention, for 30 days. participants in both intervention groups will complete 10 hiit sessions within the period of 7 days, with an additional 30 minutes of low-intensity training exclusively in hiit-hv. hiit sessions consist of aerobic hiit, i.e., 5x4min at 90-95% of maximal heart rate interspersed by 2.5 min active recovery periods. to determine the effects of the intervention, performance diagnostics, and a 5 kilometer time trial will be conducted before and after the intervention. in addition, participants are closely monitored for general health, stress, fatigue, recovery, neuromuscular performance, executive functions and sleep.

Eligibility criteria:
inclusion criteria: * female or male * aged 18-45 years * proof of physical fitness (e.g. sports medical examination required) for measurements with higher intensities (e.g. endurance tests, competition simulation) * competition experience at the national or international level in an endurance sport * vo2max ≥50ml/kg/min for females; ≥55 ml/kg/min for males or a 5-kilometer (km) time trial performance of ≤ 20:00 min (female), or ≤ 18:30 min (male) exclusion criteria: * systemic disease or other known pathology in the organs: heart, lungs, kidney, stomach, spleen, liver, gall bladder, and intestines. * evidence of pulmonary disease: forced expiratory volume in one second/forced expiratory volume \< 70% with/without symptoms (cough, sputum) or other evidence of pulmonologic disease. * diabetes ii. * neurological or psychological disease of any kind. * currently undergoing medical or psycho-therapeutic treatment. * health condition that does not allow regular participation in the training forms (e.g. acute illnesses such as fever or other flu-like infections within the last 7 days before the start of the study), orthopedic diseases, injuries to the muscular, bone, joint or tendon apparatus within the last three months. * alcohol or drug abuse. * already high training volume with high intensity training (more than 2 weekly training sessions of high-intensity training)

Keywords: high-intensity interval training microcycle endurance training load monitoring athlete performance hit training block training hit block polarized training
dermacyd delicata pocket br - photo evaluation

Conditions: Healthy

Summary: the purpose of this study is to prove the absence of photo irritation and photo sensitivity potential of the product dermacyd delicata pocket br.


Eligibility criteria:
inclusion criteria: * phototype skin ii and iii * integral skin test in the region exclusion criteria: * lactation or gestation; * use of antiinflammatory and/or immunosuppression drugs 15 days before the selection * diseases which can cause immunity decrease, such as hiv, diabetes * use of drug photosensitizer * history of sensitivity or irritation for topic products * active cutaneous disease which can change the study results * history or photodermatosis active * family or personal antecedent of cutaneous photoinduced neoplasias * presence of a precursor lesion of cutaneous neoplasia, such as nevus melanocyte and keratoses actinium * intense solar exposure in the study area * use of new drugs or cosmetics during the study the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Keywords: hygiene