Kornimate/medical-research-clean huggingface dataset:
the effect of anticoagulation after endoscopic therapy in cirrhotic patients with portal vein thrombosis

Conditions: Portal Vein Thrombosis; Liver Cirrhosis

Summary: to determine the effect and safety of anticoagulation after endoscopic therapy in cirrhotic patients with portal vein thrombosis and to explore whether it can decrease the short-term rebleeding rate.

the treatment of cirrhotic patients with pvt (portal vein thrombosis) is clearly recommended in guideline now. several published studies has confirm the effect and safety of anticoagulation therapy in cirrhotic patients with pvt.the present studies are most observation studies with small sample size and low quality.we need more high-quality research such as randomized controlled trials. this is a zelen-designed randomized controlled trial. patients will randomly enter into two groups:the anticoagulation group or the control group and then we will make sure wether their are fond of the group and make decision by themselves. the recanalization rate and complications will be analyzed

Eligibility criteria:
inclusion criteria: * age between 18-70 years old; * a clinical, radiological or histologic diagnosis of liver cirrhosis and portal hypertension; * diagnosed of portal vein thrombosis; * capable of understanding the purpose and risks of the study and informed consent to participate in the study; * have undergone endoscopy to prevent variceal rebleeding. exclusion criteria: * age \ 70 years; * portal vein thrombosis diagnosed before 6 months; * patients with signs of acute pvt such as fever，abdominal pain or intestinal obstruction，who should be treated immediately; * pregnant or nursing; * hepatocellular carcinoma; * severe cardiopulmonary diseases or concomitant renal insufficiency; * cavernous transformation of the portal vein; * contradictions to endoscopy; * contradictions to anticoagulation,such as:allergy to lmwh or warfarin, severe uncontrolled hypertension, history of hemorrhagic cerebral vascular accident, recent peptic ulcer disease, bacterial endocarditis, ulcerative colitis，sustained platelet count \< 50 x103/ul); * taking immunosuppressive agent; * coagulation disorders other than the liver disease related; * variceal bleeding failed to control.

Keywords: anticoagulation zelen-designed randomized controlled trial
medina pilot study for evaluation of the medina concept of homely rehabilitation after myocardial infarction

Conditions: Feasibility of Telemedical Home Monitoring; Post Stationary; Patients With Myocardial Infarction

Summary: in this study feasibility of the medina concept is looked at, which means telemedical services for homely rehabilitation. with the help of microsystems technology, the relevant vital signs are measured at the patient's home, then transmitted to the medina- homebox- tablet pc (by bluetooth) and then transferred into a central database, the medina ehealth- portal (by hsdpa, umts). these parameters can be continuously monitored by authorized network participants such as the family doctor or the patients themselves. in future, beyond cost advantages this will help to supervise risk patients or inspire patients to take more care of their health during homely rehab.

patients after myocard infarction who undergo homely rehab post stationary are divided into two groups of 10 patients each. the patients of group a undergo home monitoring for 4 weeks with the medina homebox and afterwards 4 weeks without home monitoring. group b starts vice versa, without home monitoring first and then undergoes home monitoring for 4 weeks (cross over,controlled intra-individually). during home monitoring with the medina homebox patients measure vital parameters (weight, blood pressure, ecg (by chest strap including micro sensors), pulse and activity (also by chest strap including accelerometer) several times a day. the pseudonomized data which are transferred via the medina homebox- tablet pc to the medina ehealth internet portal (umts, hsdpa) to which the responsible authorized medicines will have access will be evaluated descriptively.

Eligibility criteria:
inclusion criteria: * female and male patients minimum 60 years old * myocardial infarction * post stationary rehabilitation at home * internet access or mobile phone reception possible * able to give informed consent exclusion criteria: * patients with dementia * aphasic impairment * serious pulmonary diseases * motional resriction (e.g. amputee)

Keywords: feasibility compliance telemedical home monitoring post stationary rehabilitation patients with myocardial infarction
clinical study of mak immune cells in the treatment of phc

Conditions: Primary Hepatocellular Carcinoma

Summary: the investigators will plan to recruit 20 patients with liver cancer cnlc stage ⅲa and ⅲb who are older than 18 years old. peripheral blood mononuclear cells were obtained and then the mak(mixed-activated killer) cells were injected, and then the safety and efficacy were observed.

the investigators will plan to recruit 20 patients with liver cancer cnlc stage ⅲa and ⅲb who are older than 18 years old. peripheral venous blood was collected twice (50-60ml/time, 2 times, 1 week apart) from each patient. peripheral blood mononuclear cells were separated, induced, expanded, and cultured in vitro for a total of 1 week to obtain physiological conditions immune cell populations with tumor-killing activity (mainly mak immune cells mainly cd3-cd16 + cd56 + and cd3 + cd56 +), and then the mak(mixed-activated killer) cells were injected intravenously for three days. observe that the patient received cell therapy 24h, the safety and efficacy of 1 month, 2 months, and 3 months, and monitoring of adverse reactions.

Eligibility criteria:
inclusion criteria: 1. age over 18 years old, regardless of gender. 2. patients with primary hepatocellular carcinoma. 3. according to the "regulations for diagnosis and treatment of primary liver cancer (2019 edition)" by the health commission of the people's republic of china liver cancer staging scheme, patients with ⅲa and ⅲb. 4. the expected survival time is ≥6 months. 5. peripheral blood white blood cell count ≥3×10\^9 /l. 6. understand and voluntarily sign the informed consent form. exclusion criteria: 1. patients with immunodeficiency or autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, multiple primary sclerosis, insulin dependent diabetes, etc.). 2. patients with a history of other malignant tumors in the past 5 years. 3. patients who participated in other clinical trials or clinical research treatments within 3 months before this clinical study by. 4. patients who have received other cell therapy within the past 6 months. 5. patients with fever who have not effectively controlled the infection. 6. patients with high allergies or a history of severe allergies. 7. patients who are allergic to albumin. 8. patients after organ transplantation; patients who have been using or are using immunosuppressive agents for a long time.
association of apical periodontitis with chronic kidney disease

Conditions: Chronic Kidney Diseases; Periapical Lesions

Summary: this investigation is aimed to assess the prevalence and severity of apical periodontitis (ap) in different stages of ckd patients and its impact on the systemic (nutritional and inflammatory) markers was compared to healthy individuals.

105 ckd patients (35 early (eg), 35pre-dialysis (pdg) and 35 hemodialysis (hdg)groups and 105 age and gender matched healthy controls were assessed for prevalence and severity of apical periodontitis and oral disease burden . inflammatory (hscrp and ferritin) and nutritional (urea and creatinine) markers were estimated and egfr was calculated for the study population. logistic regression was used to determine the possible association between ckd and ap in study population and linear regression was performed to evaluate the possible association between systemic markers and endodontic burden (eb) in experimental group.

Eligibility criteria:
inclusion criteria: * known patient of ckd stages 1,2,3,4 \& 5 with estimated glomerular filtration rate \[egfr; mdrd\] with mature permanent teeth. * \> 18 years * \> 8 natural teeth. * complete medical \& dental history including panoramic radiographs of maxilla \& mandible exclusion criteria: * patients having systemic disorders other than ckd (eg hiv, diabetes mellitus, coronary heart disease, history of secondary hyperparathyroidism). * pregnancy, lactation \& contraceptives. * systemic conditions that contra indicates dental treatment. * use of antibiotics \& anti-inflammatory in last 3 months * need for antibiotic prophylaxis. * hepatitis c and b virus. * patients on steroids.

Keywords: apical periodontitis root canal treatment
three care models for elderly patients with hip fracture

Conditions: Hip Fracture

Summary: hip fracture in the elderly is associated with excess mortality of 5 to 20%, and mobility problems that usually results in costly hospital stays and lengthy rehabilitation procedures. the purpose of this study is to compare the costs and effectiveness of three care models- acute/sub-acute, comprehensive, and routine care models for hip fractured elders in taiwan.

hip fracture in the elderly is associated with excess mortality of 5 to 20%, and mobility problems that usually results in costly hospital stays and lengthy rehabilitation procedures. with this increase in the aging population, hip fracture represents a major and a fast growing health care problem in taiwan. currently, the incidence rate of hip fractures is 10 times of the incidence rate for the general population. despite the use of advanced treatment, the one-year mortality rate (15.4%) remains significant, and many of the patients never recover completely in terms of activities of daily living functions. many studies in the united states have proved that elderly patients with hip fracture can benefit from post-operative rehabilitation, early discharge planning programs, or transitional care programs. however, little is known about what intervention should be attempted for these patients and their families in taiwan. the purpose of this study is to compare the costs and effectiveness of three care models- acute/sub-acute, comprehensive, and routine care models for hip fractured elders in taiwan.

Eligibility criteria:
inclusion criteria: * age 60 years or older * admitted to hospital for an accidental single-side hip fracture * receiving hip arthroplasty or internal fixation * able to perform full range of motion against gravity and against some or full resistance, and have a pre-fracture chinese barthel index (cbi) score \>70 * living in northern taiwan exclusion criteria: * severely cognitively impaired and completely unable to follow orders (determined by a chinese mini-mental state examination \[mmse\] score \<10), or * terminally ill

Keywords: elderly hip fracture intervention program
seizure control as a new metric in assessing efficacy of tumor treatment in patients with low grade glioma

Conditions: Brain Neoplasm; Low Grade Glioma; Seizure Disorder

Summary: this study investigates how seizures can vary over time with changes in low grade gliomas and its treatments. this study may help doctors find symptoms or triggers of seizures earlier than normal, and ultimately earlier care or treatment for seizures.

primary objective: i. to evaluate the rate of change of seizure frequency and the status of the tumor at each data collection point. secondary objectives: i. to obtain sufficient number of patients' data in order to power the analysis to determine whether a change in seizure frequency correlates with tumor control. ii. evaluate progression free survival and overall survival when compared with seizure control. outline: patients complete a seizure assessment survey over 5 minutes at each clinic visit.

Eligibility criteria:
inclusion criteria: * adult patients * primary brain tumors (separated by world health organization \[who\] grade i-iv) * history of seizures secondary to brain tumor * on tumor directed treatment * magnetic resonance imaging (mri) within 2 weeks of clinic visit where seizure assessment takes place exclusion criteria: * patients without seizures * patients with intracranial lesions other than primary brain tumor * patients not undergoing tumor directed treatment * absence of recent (within 2 weeks) mri
insulin pump therapy and continuous glucose monitoring in diabetic continuous ambulatory peritoneal dialysis (capd) patients

Conditions: Diabetes; Poor Glycemic Control

Summary: the aims of this study are to assess the potential efficacy and safety of insulin pump to improve glycemic control in conjunction with continuous glucose monitoring (cgms) for diabetic continuous ambulatory peritoneal dialysis (capd) patients.

diabetic nephropathy now accounts for 20% to 40% of all patients entering end-stage renal failure (esrf) programs. the quality of glycemic control is known to be an important determinant of the rate of progression of patients with diabetic continuous ambulatory peritoneal dialysis (capd) patients. diabetic capd patients are usually treated with dialysis fluids utilizing glucose as the osmotic agent to provide ultrafiltration. most of diabetic capd patients had hba1c readings above 7% despite the recommendation to keep the reading below 7%. the continuous blood glucose monitor (cgms) has recently offered an opportunity to monitor blood glucose at 5-minute intervals for 72 continuous hours in diabetic patients. the cgms patterns reveal blood glucose tracings well above the recommended standards of control in most of the diabetic capd patients. good glycemic control is often difficult to maintain in diabetic patients treated with capd because they are continuously exposed to high concentrations of glucose in peritoneal dialysate. however, recent studies have suggested that diabetic patients who use insulin pump has been shown to reduce glycated hemoglobin levels without an increased risk of hypoglycemia, as compared with a regimen of multiple daily insulin injections, but results in diabetic capd patients have not been reported.

Eligibility criteria:
inclusion criteria: 1. age 18 - 70 years old at registration 2. type 1 or type 2 diabetic capd patients for at least 3 month and less than 60 months 3. hemoglobin a1c of at least 7.5% at registration kt/v is greater than 1.7 exclusion criteria: 1. have peritonitis in recent 3 months other active bacterial infections 2. unstable clinical conditions or evidence of malignancy 3. pregnancy 4. non-diabetic esrd patients 5. individuals already receiving diabetes therapy via an insulin pump

Keywords: continuous glucose monitoring capd patients insulin pump
formation and severity of pressure ulcers associated with 4% albumin vs. 0.9% sodium chloride

Conditions: Pressure Ulcer, Area; Pressure Ulcer, Grade; Albumin Level; Risk Score; Length of ICU Stay

Summary: patients resuscitated with 4% albumin will have less incidence and reduced severity of pressure injuries than patients resuscitated with 0.9% sodium chloride due to the improved intravascular oncotic pressure effected from higher albumin levels.

pressure ulcers incur multiple risks to the patient. the disruption of the skin is a portal of entry for infection , which may remain localised to the site or become blood borne. a pressure ulcer can lead to protein and fluid losses from the wound exudate. many authors have theorised the existence of a relationship between the development of pressure ulcers and low serum albumin levels however, there is no strong evidence to prove this correlation. the literature does demonstrate a clear relationship between people with existing pressure ulcers and the presence of low serum albumins. specifically serum albumin levels \<30mg/dl have been associated with the incidence of pressure ulcer development.

Eligibility criteria:
inclusion criteria: randomisation to the safe study - exclusion criteria: in addition to the safe exclusion criteria, pre-existing pressure ulcers (developed prior to icu admission) will also be excluded-
after cesarean time interval for exercise (active) trial

Conditions: Postoperative Complications

Summary: the purpose of this study is to test whether or not activity restrictions after a cesarean section are warranted and if exercise can improve postpartum wellness. this research study is being done because there is no science-based evidence to support postpartum activity restrictions after cesarean sections. participants will be randomly placed into one of the following study groups: * standard postpartum and post-operative instructions group: activity restrictions, including no strenuous exercise, sexual intercourse, or lifting objects greater than 25 pounds for 6 weeks or until evaluation at the 6 week postpartum visit * study group: structured 10 week exercise protocol consisting of core strengthening exercises (concentrating on the abdominal, gluteal, and pelvic areas), breathing exercises, and diaphragm exercises.


Eligibility criteria:
inclusion criteria: * pregnant woman at least 18 years of age * carrying only one baby at time of delivery * delivery planned by scheduled cesarean section * baby of gestational age of \> 37 weeks * no known restrictions to exercise. exclusion criteria: * woman with pre-existing post operative complications * medical history with exercise limitations/disabilities * carrying more than one baby at time of delivery * delivery (planned by scheduled or emergent) cesarean section with fetal concerns (anomaly, growth restriction, nicu admission, etc)

Keywords: postpartum wellness postoperative activity postoperative complication postpartum complication
bilateral external oblique i̇ntercostal (eoi) plane block in patients undergoing laparoscopic cholecystectomy.

Conditions: Laparoscopic Cholecystectomy

Summary: this study will define the postoperative analgesic effect of ultrasound-guided bilateral external oblique i̇ntercostal (eoi) plane block and compare the control group in patients undergoing laparoscopic cholecystectomy. the aim of this study is to compare postoperative opioid consumption of eoi plane block versus control group. it is hypothesized that postoperative opioid use will be less in patients with eoi plane block than in patients who only receive routine multimodal analgesia.

laparoscopy is a minimally invasive procedure, but postoperative pain is still the most common symptom after laparoscopic cholecystectomy (lc). regional blocks used in addition to multimodal analgesia for postoperative pain after lc usually block the anterior branches of the intercostal nerves. after it was suggested by hamilton et al. in 2018 that it could block the lateral cutaneous branches between t7-t11 intercostal nerve by administering local anesthetic to the thoracic facial plane and could be used in lateral abdominal surgeries, the eoi plane block has become a block that can be used for analgesic purposes in upper and lateral abdominal surgeries. blocking the anterior and lateral branches together may produce analgesia in a wider area, resulting in less postoperative opioid consumption. this study will be conducted as a single-center, prospective, randomized trial in a university hospital. patients scheduled for elective laparoscopic cholecystectomy will be screened for enrollment in the study. after randomization, eoi plane block will be performed under ultrasound guidance after administering general anesthesia and prior to the skin incision. an anesthesiologist who performed blocks will not involve in the data collection. other health care workers who will involve in the evaluation of postoperative opioid consumption,pain scores, nausea and vomiting, antiemetic use, and quality of recovery score will be blinded to group assignment.

Eligibility criteria:
inclusion criteria: patients' age between 18 and 70 years with american society of anesthesiology (asa) physical status i-ii, who will be scheduled for an elective laparoscopic cholecystectomy surgery included in the study. exclusion criteria: * presence of coagulation disorder * infection at the injection site of the block * known allergy to local anesthetics * advanced hepatic or renal failure * can not communicate in turkish * history of abdominal surgery or trauma * conversion of laparoscopic to open surgery * consumption of any pain killers within the 24 h before the operation * chronic opioid consumption * pregnancy * alcohol or drug abuse * body mass index (bmi) ≥ 35 kg m-2.

Keywords: laparoscopic cholecystectomy acute postoperative pain nerve block
effect of motor relearning programme and mirror therapy along for improving hand function in patients with stroke.

Conditions: STROKE

Summary: study was conducted effectiveness of motor relearning programme and mirror therapy along with conventional physiotherapy treatment for improving hand function in patients with stroke. study was an experimental study conducted on 12 stroke patients using convenient sampling method .subjects were divided into two equal groups (n=6). group a was given conventional physiotherapy and motor relearning programme exercises for the affected hand and group b received conventional physiotherapy for the affected hand and mirror therapy for the unaffected hand. chedoke arm and hand inventory (cahai) was used as primary outcome measure for evaluation of hand function before and after application of therapeutic intervention

title: effectiveness of motor relearning programme and mirror therapy along with conventional physiotherapy treatment for improving hand function in patients with stroke. background upper extremity complications are common following stroke. individuals who have sustained stroke are often left with residual motor deficits of the upper limb. these deficits restrict functional use of the limb in everyday activities and can result in increased dependen cy upon others to engage in some tasks. objectives present study aims to see effectiveness of mirror therapy and motor relearning programme for improving hand functions in stroke. materials and methods present study was an experimental study conducted on 12 stroke patients using convenient sampling method .subjects were divided into two equal groups (n=6). group a was given conventional physiotherapy and motor relearning programme exercises for the affected hand and group b received conventional physiotherapy for the affected hand and mirror therapy for the unaffected hand. chedoke arm and hand inventory (cahai) was used as primary outcome measure for evaluation of hand function before and after application of therapeutic intervention

Eligibility criteria:
inclusion criteria: * experienced one episode of stroke only, * both ischemic \& hemorrhagic stroke individuals * duration of stroke between 1 to 6 months, * mini mental status examination (mmse) (score \> 23), * brunstrom stage 4 \& 5. exclusion criteria: * any musculoskeletal disorders, * neurological disorder other than stroke, * visual impairment, systemic disease, * non co-operative patients * psychological problems.

Keywords: mrp, mirror therapy, stroke