Kornimate/medical-research-clean huggingface dataset:
study of abt-333 in both healthy volunteers and hepatitis c virus (hcv) + genotype 1 infected subjects

Conditions: HCV Infection

Summary: the purpose of this study is to assess the safety, tolerability, pharmacokinetics of abt-333 in healthy volunteers and the antiviral activity in hcv infected subjects.

phase 1, double-blind, randomized, placebo-controlled clinical trial in healthy and hcv genotype 1 infected adults to evaluate safety, tolerability, antiviral activity and pharmacokinetics of abt-333.

Eligibility criteria:
inclusion criteria: * main selection criteria for healthy volunteers: * subject has provided written consent. * subject is in general good health. * if female, subject is postmenopausal. * if female, subject is not pregnant and is not breast-feeding. * main selection criteria for hcv+ subjects: * subject is hav-igm, hbsag or hiv ab negative. * subject is hcv genotype 1 with hcv rna of \> 50,000 iu/ml. * subject is excluded if they have previously received antiviral therapy for hcv infection * subjects must demonstrate chronic hepatitis c infection for at least 6 months prior to study enrollment * subjects must have a prior liver biopsy with histology consistent with hcv induced liver damage, and with no evidence of cirrhosis or liver pathology due to any cause other than chronic hcv. exclusion criteria: see above for main selection criteria
a feasibility study exploring the effect of remicade on the disease activity in ra patients (study p05417)

Conditions: Rheumatoid Arthritis

Summary: this observational study will explore the swedish national population of patients with rheumatoid arthritis (ra) on infliximab maintenance therapy in order to identify patients who may be eligible for a dose reduction study. patients will be asked a variety of questions regarding their treatment dosing and disease activity, and then asked whether or not they would consider participating in a dose reduction study. patients in this study will be described in terms of demographic and disease characteristics.

already known subjects (ra and on at least 12 months ongoing remicade treatment) from the clinic could participate if they are eligible.

Eligibility criteria:
inclusion criteria: * rheumatoid arthritis, infliximab maintenance treatment for at least the past 12 months, given written informed consent. exclusion criteria: * episodic treatment with infliximab
cranio-caudal and lateral approach for recurrent laryngeal nerve

Conditions: Recurrent Laryngeal Nerve Injuries

Summary: the recurrent laryngeal nerve (rln) dissection should be performed cranio-caudally in toetva approach.the aim of this study was to compare the cranio-caudal and lateral approach for rln dissection in regard with the rates of los during conventional thyroidectomy using continuous intraoperative nerve monitoring (cionm).

during the thyroid surgery, the identification of the recurrent laryngeal nerve (rln) and the dissection through its entry point is still the gold standard in prevention of the nerve injury and to decrease the rln palsy rate. intraoperative nerve monitoring (ionm) has also so many benefits to search, identify and dissect the nerve through its course during thyroid surgery and especially the most important benefit of the ionm is to have real time information about the function of the rln. most of the endocrine surgeons use the inferolateral approach for rln identification under the guidance of the ionm in the recent years. however after the definition of the transoral endoscopic thyroidectomy vestibular approach (toetva) technique, the approach to the rln have to be changed to craniocaudal approach in which a way that most of the surgeons are not familiar with. the different approaches of the recurrent laryngeal nerve depend on the indications and on the surgeon's habit. several approaches exist such as the superior approach ,the lateral approach, and the inferior approach.

Eligibility criteria:
inclusion criteria: * multinoduler goitre * thyroid papillary cancer * solitary thyroid nodule exclusion criteria: * previous thyroid or parathyroid surgery, * substernal goiter, * preoperative vcp, * evidence of lateral lymph node metastasis, * intentional transection of the rln due to tumor invasion, * failure to assess rln functioning due to equipment issues with the ionm setup, * presurgical dissection amplitude of \<500µv, * patient's refusal to participate

Keywords: cranio-caudal approach lateral approach intraoperative nerve monitoring
the effect of pca on ponv after microvascular decompression

Conditions: Postoperative Nausea and Vomiting

Summary: this study is a randomized, controlled, double-blinded, and parallel design study. a total 94 patients will be randomized to receive ketorolac or fentanyl based patient-controlled analgesia after microvascular decompression surgery.


Eligibility criteria:
inclusion criteria: * patients who undergo elective microvascular decompression surgery * american society of anesthesiologists grade 1 or 2 * 19 - 65 years old exclusion criteria: * refuse to participate to the study * refuse to use patient-controlled analgesia * body mass index \ 35 kg/m2 * history of craniotomy or chemotheraphy * patients who used preoperative antiemetics within 24h before surgery * severe renal or hepatic dysfunction * pregnant
a pilot study testing onabotulinum toxin a versus incobotulinum toxin a injections for facial wrinkles

Conditions: Wrinkles

Summary: the purpose of this study is to compare the effectiveness of botox® (onabotulinum toxin a) versus xeomin® (incobotulinum toxin a) for the treatment of forehead and glabellar (vertical lines between the eyebrows) wrinkles.

subjects will be screened, photographed, assessed, and randomized to be injected with onabotulinum toxin a on one side and incobotulinum toxin a on the other side during their first clinic visit. subjects will return for a 2 week, 2 month, 3 month, 4 month, 5 month, and 6 month follow-up to have photographs taken by the unblinded research assistant at relaxed and full contraction. this study is a pilot study designed to determine feasibility of these procedures.

Eligibility criteria:
inclusion criteria: 1. females and males 2. in good health 3. is 20-65 years of age 4. has static and moderate dynamic forehead/glabellar wrinkles 5. has willingness and the ability to understand and provide informed consent and communicate with the study staff exclusion criteria: 1. pregnant or lactating 2. younger than 20 or older than 65 years of age 3. has received the following treatments in the forehead or glabellar region: 1. botulinum toxin injections in the past 6 months 2. ablative laser procedure in the past 6 months 3. radiofrequency device treatment in the past 6 months 4. ultrasound device treatment in the past 6 months 5. medium to deep chemical peel in the past 6 months 6. temporary soft tissue augmentation material in the area to be treated in the past year 7. semi-permanent soft tissue augmentation material in the area to be treated in the past 2 years 8. permanent soft tissue augmentation material in the area to be treated 4. is planning to receive within the next 6 months, any cosmetic procedure (such as any chemical peels, botulinum toxin injections, ablative or non-ablative laser procedures, filler injections, radiofrequency procedures, dermabrasion, ultrasound and face lifting procedures) in the forehead or glabellar region. 5. is planning to use tretinoin or retinoic acid in the next 6 months 6. has an active infection in the forehead or glabellar region (excluding mild acne) 7. is allergic to cow's milk protein 8. is allergic to albumin 9. taking aminoglycoside 10. is currently using anticoagulation therapy 11. has a history of bleeding disorders 12. has a mental illness 13. unable to understand the protocol or to give informed consent
multicenter symphony il-6 monitoring sepsis icu study

Conditions: Sepsis; Septic Shock

Summary: the primary objective of this study is to establish an il-6 concentration cutoff and optimal time point(s) for using symphony il-6 that predict 28-day mortality in patients who are admitted or are intended to be admitted to the intensive care unit (icu) diagnosed with sepsis or septic shock.


Eligibility criteria:
inclusion criteria: * adult patients (≥22 years of age) * diagnosis of sepsis or septic shock based on: the third international consensus definitions (sepsis-3 criteria) defined as at least one of the following criteria as determined by a treating physician or study physician investigator. * admitted or intended to be admitted to the icu * at least 0.4ml plasma drawn and available for collection (or is anticipated to be able to be drawn and available) within 12 hours of the earliest diagnosis of sepsis or septic shock. exclusion criteria: * prisoners or imprisonment at time of enrollment * prior enrollment into this study * informed consent as approved by irb is unable to be obtained.

Keywords: interleukin-6 il-6 risk stratification infections toxemia systemic inflammatory response syndrome inflammation pathologic processes sepsis septic shock shock
serological evaluation of 77a/g and 11a/12a gene of mmp-13 in periodontitis affected and healthy individuals

Conditions: Generalized Adult Periodontitis

Summary: 50 periodontitis 50 healthy individuals serological evaluation will done to see association of 77a/g and 11a/12a gene polymorphisms of mmp-13

* the study will be conducted on 100 individuals * 50 chronic periodontitis and 50 healthy individuals will be recruited from the out patient department of periodontics in the study. * an informed consent will be obtained from patients who wish to participate in the study. * patients will be categorized by periodontal disease index (pdi) by p. ramfjord(1959) * after clinical examination, blood samples will be collected and assessed for mmp 13 gene polymorphisms. * subjects will be selected according to the study criteria and divided into two groups (50 each). 1. test group 2. control group

Eligibility criteria:
inclusion criteria:• test group 1. patients with chronic periodontitis classified according to american academy of periodontology ( aap) 1999 2. subjects aged between 30-55 years * control group systemically and periodontally healthy individuals of same age group exclusion criteria: 1. present and past smokers 2. presence of any systemic diseases. 3. oral diseases other than periodontitis 4. with a previous history of periodontal treatment in the past 6 months and subjects under any medications. 5. family history of any diagnosed genetic disorders.
a novel method for determination of thromboembolic stroke origin

Conditions: Thromboembolic Stroke

Summary: rupture of vulnerable carotid, vertebral, and intracranial arterial plaques results in thromboembolic stroke. identification of these culprit lesions is an important component of post-stroke care. this study seeks to test the feasibility of naf pet-ct to detect these plaques and alter patient care. prior studies have shown a high degree of correlation between naf pet+ lesions and high-risk plaque features on high resolution mri, including mirocalcification, necrosis, and ulceration.


Eligibility criteria:
inclusion criteria: 18 years of age or older with a non-cardiogenic thromboembolic stroke in the past 14 days. exclusion criteria: less than 18 years of age, any other kind of stroke, not clinically stable to undergo pet-ct
improving critical congenital heart disease screening with addition of perfusion measurements

Conditions: Congenital Heart Disease

Summary: the purpose of this research is to evaluate and create a new clinical prediction model for cchd screening that combines non-invasive measurements of oxygenation and perfusion.

this study will create and test an enhanced critical congenital heart defect (cchd) screen that combines non-invasive measurements of oxygenation and perfusion in two ways. the first will use current equipment without automated interpretation and the second will require additional software/device but will automate the interpretation. to work towards development of those two algorithms in this stage of the study, the study team will download oxygen saturation (spo2) and perfusion index (pix) measurements from newborns with and without congenital heart disease (chd) and apply statistical tests to the data afterwards to identify parameters to include in the newly developed screening algorithms. the overall objective is to create an automated screening algorithm to improve acyanotic cchd detection, preventing morbidity and mortality associated with diagnoses missed by spo2 screening. the central hypothesis is that the addition of non-invasive perfusion measurements to spo2 will be superior to spo2-alone screening for detection of acyanotic cchd. the data collected during this study will be used to develop the two algorithms and the algorithms will be compared to the standard of care using statistical tests on the data after the fact (k-fold validation). the newly developed algorithms will not be tested in-situ on patients during this study.

Eligibility criteria:
inclusion criteria: * age \< 22 days * and either: a) asymptomatic newborn undergoing spo2 screening for cchd, or 2b) newborn prenatally or postnatally diagnosed/suspected with chd. exclusion criteria: * for controls: echocardiogram completed prior to enrollment as the newborn would then no longer be considered "asymptomatic undergoing spo2 screening for cchd" * for newborns with confirmed/suspected chd: a) patent ductus arteriosus and/or atrial septal defect/patent foramen ovale without other defects, b) corrective cardiac surgical or catheter intervention performed before enrollment or c) current infusions of vasoactive medications other than prostaglandin therapy.
alcohol consumption relation with nutritional knowledge and body weight

Conditions: Binge Drinking

Summary: the increase of overweight and obesity in young italian people, nowadays showed by several epidemiological data, has been related to the misuse of alcohol and to a lack in nutritional knowledge. thus the aim of our study was to investigate if different nutritional knowledge from could affect body composition and drinking habits of a cohort of local young people. 104 healthy subjects (56 males and 54 females) were recruited using oral advertisements among the students of 18-19 years-old belonging to the istituto agrario and the istituto alberghiero raineri-marcora of piacenza. the subjects were asked to complete a questionnaire on alcohol consumption and another one related to nutritional knowledge. then anthropometric data were measured: height, weight, waist and hips circumferences, waist-hips ratio and skinfolds were evaluated for each subject and body fat mass was calculated.


Eligibility criteria:
inclusion criteria: * students exclusion criteria: * pregnant or breast feeding * vegan or vegetarian
outcomes associated with application of a normothermia protocol in patients with severe neurological insult and fever

Conditions: Subarachnoid Hemorrhage; Severe Traumatic Brain Injury

Summary: when fever is present in patients with stroke, traumatic brain injury (tbi), or brain hemorrhage, it has been associated with worse outcomes including larger areas of tissue death, increased length of stay, worse degree of coma, lower ability to function, and higher mortality. both adult and pediatric tbi national guidelines state that maintenance of normal body temperature should be a standard of care. however, no further standards or options are presented to specifically guide practice. the current ischemic stroke guidelines state that fever should be treated with fever-reducing agents and offer "cooling devices" as an option but do not provide specifics to guide practice. over 50% of patients in the neurosurgical intensive care unit (icu) at harborview medical center develop fever during the course of their stay. with elevated temperatures the body consumes more oxygen than if the temperature was normal, causing less oxygen to be available to the brain. this may lead to injury of the brain cells and a diminished capacity for healing. thus, temperature management in neurologically vulnerable patients is both a prevalent and problematic challenge. based on this information the goal of the present proposal is to evaluate if 1) a standardized, step-wise approach to temperature management using a normothermia protocol is successful in achieving and maintaining normal temperature in neurosurgical icu patients; and 2) if maintenance of normal temperature will be associated with fewer episodes of diminished responsiveness in their neurological exams as evidenced by a measure of depth of coma, as measured by the glasgow coma score (gcs) compared to a control group treated according to usual care.


Eligibility criteria:
inclusion criteria: 1. temperature \> 38.3 celsius 2. meet brain injury criteria: * traumatic brain injury with glasgow coma scale score of 8 or less * subarachnoid hemorrhage without vasospasm- hunt and hess grade iii and below * subarachnoid hemorrhage with vasospasm 3. first febrile episode 4. english speaking exclusion criteria: 1. skin breakdown 2. bleeding disorders 3. increased risk for clotting 4. ongoing seizure activity 5. allergy to medications used in the study 6. prisoners 7. pregnancy
effects of core stabilization exercises vs. schroth's program on posture and quality of life in females with scoliosis.

Conditions: Scoliosis Idiopathic

Summary: the objective of this study is to compare the effects of core stabilization exercises versus schroth's program on posture and quality of life in females with idiopathic scoliosis

scoliosis is a 3 dimension condition that effects most of our population specifically females. it is not only a bend in your spine but according to new research, its also twisting it. the curvature effects the effected individual physical and the social anxiety due to appearance and a continues state of lethargy effects their quality of life immensely. the posture is poorly effected along with a visual appearance. often someone with scoliosis might find good posture difficult. often someone with scoliosis will lean forwards and to the side either slightly or a lot. they will often try to avoid doing this, which can lead to slightly bent knees and the pelvis tilting backwards. scoliosis is often defined as spinal curvature in the "coronal" (frontal) plane. while the degree of curvature is measured on the coronal plane, scoliosis is actually a more complex, three-dimensional problem which involves all 3 planes. it is defined by the cobb's angle of spine curvature in the coronal plane and is often accompanied by vertebral rotation in the transverse plane and hypokyphosis in the sagittal plane. these abnormalities in the spine, costal-vertebral joints, and the rib cage produce a 'convex' and 'concave' hemithorax. only females having idiopathic scoliosis with cob's angle 10°-26° with age ranging between 19-30 are included and any subjects with surgical interventions are excluded. population will be divided in to two groups. one group will perform scroth exercises for 4 weeks and the other group will perform core straightening exercises for 4 weeks each. once the time period is complete, the posture will be measured using pelvic and shoulder goniometers to check the level of tilt and for quality of lifestyle, we will be using quality of life (scoliosis research society-22 questionnaire)

Eligibility criteria:
inclusion criteria: * females only * positive forward bend test (fbt) * idiopathic scoliosis * cob's angle 10°-26° * age group ranged between 19-30 yrs. * normal bmi (18.5-24.9 kg/m2) * chronic scoliosis patients * riser sign 4-5 exclusion criteria: * subjects with any surgical intervention for scoliosis * pregnant women * subjects with any serious health condition
flavonoids and cardiovascular disease

Conditions: Cardiovascular Diseases; Heart Diseases; Cerebrovascular Accident; Myocardial Infarction; Coronary Disease

Summary: to determine the association between flavonoids intake and the prevention of incident cardiovascular disease (cvd).

background: basic science, clinical observation, and epidemiologic studies have all contributed to an emerging body of evidence on the potential role of flavonoids, a group of polyphenolic compounds with antioxidant properties, in the prevention of cardiovascular disease. however, the few existing studies on flavonoids or its food sources have provided inconsistent results, usually focusing on the primary prevention of coronary heart disease mortality. the study used the small grant mechanism (r03) to analyze previously collected data. design narrative: the investigators examined whether flavonoid intake was associated with the risk of incident cvd, and whether specific food sources of flavonoids--including tea, onions, apples, red wine, and other foods--were associated with the risk of incident cvd. the investigators processed and analyzed previously collected data of 39,876 middle-aged and older women free of cvd; the women's antioxidant cardiovascular study (wacs), a prospective study of 8,171 middle-aged and older women with pre-existing cvd or more than three coronary risk factors; the normative aging study (nas), a prospective study of 2,280 middle-aged and older men; and the boston area health study (bahs), a case-control study of first nonfatal myocardial infarction in men and women aged less than 76 years. using data from semiquantitative food frequency questionnaires administered in each study, the investigators determined individual intake of flavonoids and its food sources. unlike previous studies, they examined flavonoids in relation to both the primary and secondary prevention of incident cardiovascular disease (cvd), consisting of confirmed cases of nonfatal myocardial infarction (ml), nonfatal stroke, revascularization procedures, and cvd death. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria