Kornimate/medical-research-clean huggingface dataset:
survey on niv settings in the intensive care unit for acute exacerbation of copd

Conditions: COPD (Chronic Obstructive Pulmonary Disease); Acute Exacerbation of COPD; Hypercapnic Respiratory Failure, COPD

Summary: introduction chronic obstructive pulmonary disease (copd) is a common condition and the fourth leading cause of death worldwide. with the rise of non-invasive ventilation (niv), mortality among patients admitted for acute hypercapnic respiratory failure has decreased, though to a lesser extent than reported in the studies that validated this technique. we hypothesize that inappropriate initial ventilatory parameter settings for niv could be associated with increased morbidity and mortality in this context. objective the primary objective of this study is to assess the initial niv settings used in intensive care units (icus) and respiratory intensive care or medical intensive care units (micus) in this patient population. a secondary objective is to evaluate whether specific ventilatory settings are associated with mortality or the need for invasive mechanical ventilation (imv). methods this is a prospective multicenter observational study aiming to include 976 patients. niv settings will be recorded at initiation, after the first recommended arterial blood gas (abg) evaluation (between 1.5 and 2 hours of ventilation), and at 24 and 48 hours. patient characteristics, including medical history, clinical and biological parameters at admission, will be collected. vital status and the need for imv will be recorded at icu discharge and on day 28 (d28).


Eligibility criteria:
inclusion criteria: * adult copd patient * known or suspected copd diagnosis as assessed by the attending physicians * admitted to a medical intensive care unit (micu), respiratory intensive care unit, or micu * hypercapnic respiratory distress * niv indication determined by the physician * covered by social security exclusion criteria: * pregnant or breastfeeding women * other obstructive diseases (asthma, bronchiectasis, cystic fibrosis, bronchiolitis, pulmonary fibrosis, restrictive thoracic syndrome) central hypoventilation (ondine's syndrome, iatrogenic), neurological (neuromuscular disease), osteoarticular (kyphoscoliosis), or ent-related causes * immediate need for intubation * acute pulmonary edema * contraindications to niv (untreated pneumothorax, shock, cardiac arrest, uncontrolled vomiting, upper gastrointestinal bleeding, cervicofacial trauma, coma except when related to hypercapnia) * patients under legal guardianship * incarcerated individuals

Keywords: copd acute exacerbation of copd non invasive ventilation hypercapnic respiratory failure
the efficacy of biomarker in patient with interstitial cystitis/painful bladder syndrome

Conditions: Interstitial Cystitis

Summary: the purpose of this study is to evaluate efficacy of biomarker in patient with interstitial cystitis/painful bladder syndrome

this is a observational study

Eligibility criteria:
inclusion criteria: * 1) must have experienced bladder pain, urinary urgency and urinary frequency, for at least 6 months prior to entry into the study 2) pain vas ≥4 3) o'leary-sant interstitial cystitis questionnaire (ic-q) symptom and problem ≥ 12( and pain ≥2, and nocturia ≥ 2) 4) puf score ≥ 13 5) cystoscopic record within 2 years exclusion criteria: 1. patients who are pregnancy or, childbearing age without no contraception 2. patients with voided volume \ 400ml 3. patients with microscopic hematuria, (≥1+ in dipstick), if not excluded that no evidence of neoplastic tumor examination 4. patients with urine culture showing evidence of urinary tract infection 1month prior to the study 5. accompanied medical problem below * tuberculosis in urinary system * bladder cancer, urethral cancer, prostate cancer * recurrent cystitis * anatomical disorder 6. patients had prior surgery (eq, bladder augmentation, cystectomy 7. patients with neurologic disorder 8. patients with indwelling catheter or intermittent self-catheterization 9. patients with psychologic problem

Keywords: biomarkers
nutritional assessment in non-tuberculous mycobacteria pulmonary disease

Conditions: Non-Tuberculous Mycobacterial Pneumonia

Summary: non-tuberculous mycobacterial (ntm) pulmonary disease (pd) is an emerging condition with heterogeneous manifestations from both the microbiological and the clinical point of view. diagnostic and therapeutic guidelines are available but there are still unmet patients' and physicians' needs, including the exams to perform in the nutritional evaluation and intervention to improve health-related qol and to control gastrointestinal side-effects during antimicrobial therapy, particularly in those with low body mass index and history of weight loss.

the aim of the study is to evaluate the nutritional status in patients with non-tuberculous mycobacterial pulmonary disease (ntm-pd) and to provide an initial assessment of the potential impact of the introduction of targeted antibiotic therapy on the nutritional status itself. specifically, the primary objective is the assessment of the proportion of underweight subjects, i.e. with body mass index (bmi) \<18.5 kg/m2, to confirm that it is significantly higher than that of the general italian population. study design: multicenter cohort pilot observational study participation in the study consists of two pneumological visits, as per normal clinical practice, (at the beginning of the study, t1, after 6 months, t3, and at the end of the antimicobacterial antibiotic therapy, t5) in which the collection of past medical history, measurement of oxygen saturation, pulmonary functional tests and 6-minute walking tests will be performed. in addition, nutritional assessments (t2, t4, t6) will be carried out at the same time as the pulmonary visits. nutritional assessments will include anthropometric measurements, questionnaires on nutritional status and physical activity, performing blood chemistry tests, bioimpedance, dynamometry and gait speed 4 meters, to evaluate body composition and physical performance.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years; * diagnosis of ntm-pd according to the bts 2017 guidelines exclusion criteria: * severe renal failure, defined as a gfr (glomerular filtration rate) lower than 30ml / min; nyha class iv; * severe liver failure, defined as child-pugh score class c; * active solid or haematological neoplasms; * having already received (currently or in the prior 6 months) antimicobacterial therapy; * severe immunosuppression; * inability to walk without help; * need for oxygen therapy at rest; * participation in other interventional experimental protocols with use of a medicinal product.

Keywords: nutrition nutritional status sarcopenia malnutrition body mass index bioimpedance analysis
prevention and control of obesity in primary school children in tehran

Conditions: Childhood Obesity Prevention

Summary: this study evaluates the effect of an interventional model for preventing and controlling overweight and obesity in male and female fifth-graders. first, based on who (world health organization) references obese (bmi-z score ≥ 2) and overweight (bmi-z score ≥ 1) students from 12 primary schools (randomly allocated to 6 intervention and 6 comparison) will be screened. then from the screened students 30 students with the following inclusion criteria will be recruited: not metabolically ill, not on a weight losing diet and not professionally athlete. for selected students bmi-z score as primary outcome will be calculated. demographic data, as well as data on waist and hip circumference, triceps skin-fold thickness, food intake for 3 days (2 ordinary week days and 1 weekend) and physical activity will be collected at the beginning and at end of the 6-month intervention. the approach of the study will be health promoting schools. the intervention includes three components, i.e., nutrition education (students and parents), increased physical activity, and changing environment (food items offered in schools' canteens). nutrition education will be imparted (a 30-minute session per week) by health instructors; physical activity will be done under the supervision of the school coaches (2 one-hour sessions per week). parents' education (a 1.5-hour session) will be monthly. finally the efficacy of the intervention will be determined and reported.


Eligibility criteria:
inclusion criteria: * bmi-z-score\> or =1 (who) * students in the fifth or sixth grades exclusion criteria: * metabolic disorders (hypo or hyperthyroidism) * any disease which interfere with adherence to the intervention * intake of any appetite-reducing drug * doing professional sports * being on a weight reduction diet
nutrition intervention for chronic pain patients

Conditions: Chronic Pain

Summary: the primary objective of the study is to determine the effectiveness of nutrition education (individual and group) on the intensity of pain in patients suffering from chronic pain. the secondary goal is to determine whether there is a change in the status of the patient's nutrition, their quality of life, quality of life, and other indicators of the psychophysical condition of the patient.

the underlying hypothesis of the study is that patients with chronic pain that go through a series of nutrition education (individual and group) specifically tailored to fit their needs (based on our preliminary findings), they increase the consumption of foods that have antiinflammatory properties, which will result in lower levels of inflammatory cytokines in the body (high sensitivity c-reactive protein (hs-crp ), interleukin (il) -2, il-4 and il-6), and consequently reduce the intensity of pain. also, weight loss in obese patients is expected, and it will have an contributing effect of the intervention. patient's quality of life and indicators of their psychophysical condition (eg, depression level) are also expected to improve. chronic pain patients who either attend daily clinic (control arm) or the 4-week multidisciplinary programme at the department of anesthesiology, resuscitation and intensive care (intervention arm) will be recruited. they will be followed for total of 8 weeks (4 week intervention + 4 week follow-up).

Eligibility criteria:
inclusion criteria: * signed informed consent * chronic low back pain with or without radiculopathy patients; non-cancer pain * bmi within the range \>18 and \<35 kg/m2 * croatian-speaking * referred to a multidisciplinary pain management center * able to report on their health and pain status (neurologically stable) * pain intensity on 0-10 visual analog scale ≥ 5 prior to treatment * magnetic resonance imaging (mri) of the lumbar spine and electromyography (emng) studies completed confirming clinical symptoms of low back pain with or without radiculopathy exclusion criteria: * younger than 18 or older than 80 * cancer pain * pregnancy * disability (unable to walk) * inability to fill in questionnaires in croatian * cognitive impairment * significant, symptomatic uncontrolled psychosis * psychiatric disorder * pain intensity on 0-10 visual analog scale \< 5 prior to treatment * severe somatic disorder (oncological disease, type 1 diabetes, hepatological or nephrological) * undergoing current treatment for a major medical illness such as malignancy, autoimmune or immune deficiency disorder * acute low back pain, or shorter than 6 months * clotting disorders * bmi \<18 or over 35 kg/m2 * nutritional deficiency (e.g. iron deficiency anaemia, osteoporosis) * current or history of eating disorder (anorexia, bulimia or ednos) * current use of weight loss interventions (drugs; exercise interventions) * regular use of supplemental omega-3 fatty acids, gamma-linolenic acid or vitamin d

Keywords: chronic pain nutrition education inflammatory biomarkers
a study to evaluate the safety and efficacy of dsfnc1 soft hydrophilic contact lenses and sihy color soft hydrophilic contact lenses

Conditions: Myopia

Summary: this project is an open, parallel, randomly controlled, and non-inferiority clinical trial of dsfnc1 soft hydrophilic contact lenses with sihy color soft hydrophilic contact lenses.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years old, gender is not limited; 2. soft hydrophilic contact lenses to be worn range from 0.00 to -12.00d; 3. both eyes were normal with no other abnormality or disease other than refractive error; 4. best-corrected eyesight ≥ 1.0 in both eyes with frame lenses; 5. astigmatism ≤ 2.0d; 6. t5ar film break-up time (but) \&gt;5s in both eyes 7. those who are able to complete a minimum of 90 days of follow-up and are able to wear contact lenses as required by the protocol; 8. ability to understand the purpose of the trial, to participate voluntarily and to have informed consent signed by the subject himself/herself or his/her legal guardian. exclusion criteria: 1. persons with any systemic condition that contraindicates the wearing of contact lenses, or who are receiving treatment that interferes with vision or the wearing of contact lenses; 2. those who had worn hard contact lenses within 4 weeks or soft contact lenses within 7 days prior to enrollment in this trial; 3. people who are allergic to contact lens, and people with systemic allergic diseases; 4. patients with conical corneas or other irregular corneas; 5. those who have to wear soft hydrophilic contact lenses for a long period of time under special circumstances such as dryness, severe dust or volatile chemicals; 6. those who are pregnant, breastfeeding, or planning a pregnancy at the time of enrollment; 7. those who were eligible for enrollment in only one eye; 8. concurrent participation in other clinical trials or participation in a soft contact lens clinical trial of soft hydrophilic contact lenses within 10 days prior to enrollment in this trial 9. participants who have participated in a clinical trial of a drug or a medical device other than a contact lens within 3 months prior to enrollment in this trial; 10. other conditions that, in the judgment of the investigator, make wearing soft contact lenses unsuitable or preclude enrollment.
lifestyle interventions to reduce diabetes risk

Conditions: Glucose Intolerance; Diabetes Mellitus, Type 2

Summary: type 2 diabetes is more frequent in japanese americans than in japan or the u.s. non-hispanic white population. this appears to be due to the effects of ''westernization'' to bring out metabolic changes that lead to diabetes. this study will look at whether increased physical activity and dietary changes will reduce or prevent the metabolic changes that lead to type 2 diabetes in japanese americans who have impaired glucose tolerance, a condition intermediate between normal glucose tolerance and diabetes.


Eligibility criteria:
inclusion criteria: * japanese american * confirmed impaired glucose tolerance * able to fill out questionnaires exclusion criteria: * significant exercise-restricting disease * poorly controlled hypertension * psychiatric disease or dementia * already on unusually restrictive diet * use of hypolipidemic drugs * use of tobacco * abnormal blood screening tests * ecg evidence of ischemic heart disease at rest * abnormal maximal bruce treadmill test

Keywords: low fat diet aerobic exercise impaired glucose tolerance japanese americans metabolic risk factors
quality and independence of gait classification scale for dmd (qigs-dmd)

Conditions: Duchenne Muscular Dystrophy; Gait Disorders in Children

Summary: the aim of this study was to develop a reliable and valid gait classification scale for duchenne muscular dystrophy (qigs-dmd). the items of the qigs-dmd were designed based on the literature review considering existing functional classification scales, gait scales, and the opinions of the physiotherapists who were expertized in rehabilitation of patients with dmd. content validity was determined based on the opinions of a total of ten expert physiotherapists. videos were recorded during gait of 69 children with dmd and inter- and intra-rater reliability were examined. criterion validity was determined according to the relationship between qigs-dmd and motor function measure (mfm) and vignos lower extremity rating scale (vlers).


Eligibility criteria:
inclusion criteria: * being 5 years old or above, and * having a confirmed diagnosis of duchenne muscular dystrophy. exclusion criteria: * having other coexisting medical or psychiatric diseases or injury and/or surgery related to the lower extremities within the last 6 months

Keywords: duchenne muscular dystrophy scale development gait classification reliability validitiy
lateral lymph node dissection for middle-low rectal cancer

Conditions: Rectal Cancer

Summary: the investigators will perform ct three-dimension reconstruction for middle-low rectal cancer patients who have enlarged lateral lymph nodes to recognize the variance of pelvic vessels, by which to help reduce operative time and blood loss, localize the lateral lymph nodes, improve the lymph node harvested and positive rate. besides, the investigators will label the vessels near the interested node to achieve node-by-node for further investigation.

ct three-dimensional reconstruction was performed for middle-low patients who had enlarged lateral lymph node before surgery. the main purpose is to recognize the track and variance of pelvic and iliac blood vessels. the investigators want to explore whether this method can help reduce operative time, unexpected injuries and blood loss, and the investigators also want to study whether it can help improve the lymph node harvested and positive rate during lateral lymph node dissection. besides, the investigators want to perform node-by-node for enlarged lateral lymph node and ct three-dimensional reconstruction can help the investigators to localize and label the interested lymph node during operation. after node-by-node, the investigators can explore the accuracy of radiologists' and surgeons' judgement for lateral lymph node metastasis, and the investigators also want explore the best cut-off value of shorter diameter to predict lateral lymph node metastasis. besides, the investigators want to perform texture analysis by combination radiology and pathology to find some useful parameters to predict lateral lymph node metastasis. the investigators also want to explore the feasibility of dissecting the unilateral visceral branch of internal iliac vessels when performing lateral lymph node dissection. the investigators will have a close follow-up for patients who have enlarged lateral lymph node but do not meet the criteria for lateral lymph node dissection. ct three-dimensional reconstruction can help the investigators recognize which parts' lateral lymph nodes have more potential possibility to metastasis and recurrence.

Eligibility criteria:
inclusion criteria: 1) confirmed rectal cancer; 2) tumor located less than 10 cm from the anus verge; 3) have enlarged lateral lymph on preoperative ct/mri exclusion criteria: 1) patients who have severe liver or renal dysfunction;

Keywords: lateral lymph node dissection node-by-node rectal cancer ct three-dimensional reconstruction internal iliac vessels dissection
stretch of respiratory muscles in patients with chronic obstructive pulmonary disease

Conditions: Dyspnea; Quality of Life; Respiratory Symptoms

Summary: the aim of this study is to test if the stretching of the respiratory accessory muscle provide some benefit on thoracoabdominal mechanics, functional capacity, psychological and social aspects in patients with chronic obstructive pulmonary disease

patients with chronic obstructive pulmonary disease will be submitted to passive stretching of respiratory muscles and exercise in treadmill during 12 weeks, twice a week. one week after the training period, the functional capacity, the thoracoabdominal mechanics and levels of anxiety and depression will be assessed.

Eligibility criteria:
inclusion criteria: * chronic obstructive pulmonary disease diagnosis * clinical stability * absence of previous thoracic surgery * absence of other limitations exclusion criteria: * copd exacerbation * absence greater than three days

Keywords: chronic obstructive pulmonary disease thoracoabdominal mechanics functional capacity quality of life
the effect of multimodal nutrition intervention on glucose and lipid parameters of arfa iron and steel company workers

Conditions: Blood Sugar; Lipid Profile; Weight Change

Summary: the goal of this clinical trial is to investigate the impact of nutritional interventions on glycemic and lipid profile factors among workers. the main questions it aims to answer are: does nutritional interventions (include: nutritional education and change in the factory restaurant's menu improve glycemic and lipid profile factors among workers? researchers will compare glycemic and lipid profile factors among workers before and after nutritional intervention .


Eligibility criteria:
inclusion criteria: * be arfa's company worker exclusion criteria: * individuals who were diagnosed with any type of cancer

Keywords: public health workers nutrition
surveillance study for early detection of cholangiocarcinoma (cca) in primary sclerosing cholangitis (psc)

Conditions: Primary Sclerosing Cholangitis; Cholangiocarcinoma

Summary: this observational study of a national cohort of 600 swedish psc patients include yearly mr/mrcp, biobanking of serum, plasma and blood, followup clinical data (interventions, symptoms, labs, colonoscopy). the aim is to collect a well characterized cohort of psc patients and provide future possibilities to evaluate biomarkers for prognosis and early cancer detection.


Eligibility criteria:
inclusion criteria: * diagnosis of psc by mr/mrcp * life expectancy \>1 year * informed consent exclusion criteria: * liver transplantation or on the waiting list * secondry sc * diagnosis of cca
trans-theoretical model based home visiting on medication behavior

Conditions: Hypertension; Medication Adherence

Summary: this study was a single-blinded, two-armed, randomized controlled trial comparing a medication self-management intervention to usual care for hypertensive elderly in the residential care facility. to explore the effect of stage-matched tailored education on disease management for hypertensive elderly. patient were randomly assigned to either a 6-month trans-theoretical model-based medication management intervention group or a treatment-as-usual group. we would like to improve its adherence to the medicine prescribed by their own physician through five sessions of face-to-face interview which focused on anti-hypertensive medication-related information, the importance of medication refills, motivation, self-management and self-check skills.

this study was a single-blinded, two-armed, randomized controlled trial comparing a medication self-management intervention to usual care for hypertensive elderly in the residential care facility. from october 2018 to november 2018, convenience sampling was used to recruit 120 participants from one of the most extensive facilities in zhengzhou, china. individuals aged 65 years of age or older diagnosed had stage i or stage ii hypertension (140-159/90-99 mm hg or 160-180/100-110 mm hg, respectively), as confirmed by the professional physician and prescribed anti-hypertensive medication by the physician for at least six months and with an estimated life expectancy of no less than six months were included.the intervention included five educational sessions focused on anti-hypertensive medication-related information, the importance of medication refills, motivation, self-management and self-check skills.

Eligibility criteria:
inclusion criteria: 1. aged 65 years of age or older 2. diagnosed with a stage i or stage ii hypertension (140-159/90-99 mm hg or 160-180/100-110 mm hg, respectively), as confirmed by the professional physician 3. prescribed anti-hypertensive medication by the physician for at least six months exclusion criteria 1. unable to communicate and take medications by themselves. 2. with an estimated life expectancy of no more than six months. -