Kornimate/medical-research-clean huggingface dataset:
normal saline vrs balanced i.v. fluids in neurosurgery

Conditions: Benign Neoplasms; Vascular Malformations, Brain

Summary: the purpose of this study was to investigate whether the balanced fluids therapy change plasma osmolality in neurosurgical procedures due to brain tumors, meningeomas and arterio-venous malformation.

normal saline or 0.9% sodium chloride solution is the most commonly used intravenous fluid worldwide and its composition are 154 mmol na+ and 154 mmol cl- per litter with osmolality of 308 mosmol/l. that composition is not "normal" because plasma contains potassium in range between 137-146 mmol/l, and chloride in range between 98-106 mmol/l, with plasma osmolality of 280-295 mosmol/kg. recently published data suggested detrimental effects of chloride rich fluids on renal blood flow and glomerular filtration rate, urine output and acute kidney injury. one alternative to saline solution is a buffered, balanced, crystalloid solution with an electrolyte composition similar to plasma and osmolality between 286-295 mosmol/l. someone could indicate that such balanced solutions are not suitable for neurosurgical patients because of a possible impact on the brain edema development.

Eligibility criteria:
inclusion criteria: * patients with brain tumor, meningeomas and vascular malformation. exclusion criteria: * patients with signs of elevated intracranial pressure; history of kidney disease, history of heart disease

Keywords: balanced fluids, neurosurgery, plasma osmolality
active powered prosthesis (apex) for spinal cord injury

Conditions: Spinal Cord Injuries

Summary: the active powered prosthesis (apex) (abilitech medical inc., minneapolis, mn) is a proof-of-concept shoulder-elbow-wrist device intended to provide non-invasive active powered robotic assistive movement to upper extremities. the objective of this study is to perform focus groups with users and clinicians to evaluate a proof of concept active powered assistance device.


Eligibility criteria:
inclusion criteria: 1. spinal cord injury at levels c3 to c5, and ais a, b, or c 2. greater than 3-months post injury or surgery to the spinal column, arms, or shoulder 3. ability to provide informed consent 4. age 18 or over 5. selected for participation based on investigator discretion exclusion criteria: 1. unable to follow instructions 2. exhibit significant behavioral problems or impaired cognitive ability 3. inability to provide consent 4. non-english speaker
evaluation of peri-surgical results at short and mean terms of the gore ® excluder iliac branch endoprosthesis

Conditions: Iliac Aneurysm

Summary: the aim of this project is to demonstrate the benefit of the use of aortic iliac branch endoprosthesis in the iliac aneurysms and to avoid the classic complications.


Eligibility criteria:
inclusion criteria: * high surgical risk: * comorbidity cardiopulmonary * renal insufficiency * hostile abdomen including ascites or portal hypertension * anatomic criteria: * primitive iliac aneurysm superior to 25 mm without collar * primitive iliac length superior to 40 mm * primitive iliac distal diameter superior to 14 mm * presence of internal iliac collar * affiliation to a social security system exclusion criteria: * patient without surgical risk * non-respect of the anatomic criteria * patient with known allergy to the materials of the device * patient with systemic infection * patient with severe renal insufficiency * patient unable to complete the oximetry test * persons under legal protection
fmri of language recovery following stroke in adults

Conditions: Aphasia; Stroke

Summary: the purpose of this study is to test the effectiveness of constraint-induced aphasia therapy.

aphasia (difficulty speaking) is one of the most dreaded consequences of stroke. it is associated with high mortality and severe motor, social, and cognitive disability. during the past decade, therapies administered by stroke teams have made great strides in limiting the damage due to a stroke. unfortunately, progress in aphasia rehabilitation has not experienced the same rapid advancement. evidence suggests that the brain may have untapped potential for recovery of aphasia after stroke. using functional magnetic resonance imaging (fmri), researchers now are able to examine the areas of the brain that are responsible for language recovery after stroke. such data may explain how the brain recovers after stroke, and may lead to new therapies to help individuals who have suffered an aphasia-causing stroke. in this study, researchers will examine the changes the brain undergoes while recovering from an aphasia-causing stroke and the mechanisms that underlie such recovery, and test the effectiveness of a new and promising method of aphasia rehabilitation called constraint-induced aphasia therapy (ciat). the scientists will perform fmri studies of brain activation in people who have suffered an aphasia-causing stroke in order to better understand the underlying mechanisms of recovery from aphasia. specifically the researchers will compare language activation between adults with stroke and children with perinatal and postnatal stroke (from previous studies); map changes in language activation, characterize the patterns of language reorganization that occur following stroke; and use the fmri measures to assess recovery using ciat. the study will last one year, during this time participants will have language testing to evaluate the degree of aphasia and its recovery; and five fmri scans scheduled at 2 weeks, 6 weeks, 12 weeks, 26 weeks, and 56 weeks. participants with remaining moderate aphasia will be offered a chance to participate in an extension treatment study that will last up to 3 months (study). a better understanding of brain changes during recovery from aphasia may help develop new methods to improve recovery.

Eligibility criteria:
inclusion criteria: * mca stroke as indicated by the presence of aphasia and mri lesion in the lmca distribution * moderate aphasia (token test score between 40th and 90th percentile) * written informed consent by the patient or the next of kin exclusion criteria: * underlying degenerative or metabolic disorder or supervening medical illness * severe depression or other psychiatric disorder * pregnancy * any contraindication to an mri procedure (i.e., metal implants, claustrophobia)

Keywords: aphasia stroke functional magnetic resonance imaging fmri language recovery after stroke constraint-induced aphasia therapy ciat
measurement algorithm control and optimization with subsequent performance evaluation of sanmina non-invasive biosensors during a standardized meal test in patients with diabetes mellitus type 1 and type 2

Conditions: Diabetes Mellitus

Summary: measurement algorithm control and optimization with subsequent performance evaluation of sanmina biosensors in monitoring of glucose, heart rate (hr), and spo2 in patients with type 1 and type 2 diabetes during a standardized meal experiment.

* this study is a combined, open label, prospective, comparative single-center study. * the study is separated in 3 consecutive study parts. the first 2 study parts include 12 patients each. in the third study part 36 patients will be enrolled. study part 1 and 2 will be used for optimization and control of the measurement algorithms of the sanmina biosensors. during the third study part with enrolment of 36 patients, the precision and accuracy of the final sanmina biosensor algorithm will be demonstrated. the study conduct for all 60 participants of all 3 study parts will be exactly the same. in all groups of participants, the sanmina finger clip and wearable non-invasive monitoring biosensor will be individually introduced and assigned. during the study visit at the study site, a standardized meal will be given to the participants. at eleven time points before and after the standardized meal, glucose, heart rate, and po2 will be measured using the sanmina finger clip and wearable non-invasive monitoring biosensor. the measurement time points are -30, 0, 15, 30, 45, 60, 75, 90, 120, 150 and 180 min. the measurements will be compared to capillary blood glucose measurements by ysi stat 2300 and statstrip (glucose), and parallel measurements of the heart rate and the po2 using a patient monitor. further the exact skin colour will be evaluated using a skin colour card.

Eligibility criteria:
inclusion criteria: * type 1 or type 2 diabetic subjects or healthy probands * subjects who are able to complete informed consent form (by him/herself or by his/her guardian); * 18 years old and above; * anatomically suitable finger in discretion of the investigator exclusion criteria: * does not meet inclusion criteria; * any conditions that may hamper good visual contact between the finger or wrist and sensor, such as raised birthmarks, scars, tattoos; * pregnancy; * nursing mothers; * any skin scratch(es), damage, over dry, long nails on the measured finger; * unsuitable finger with the device might be excluded if recognized during the trial; * medication containing nitrates
study about high fat meal and postprandial lipemia

Conditions: Obesity

Summary: the hypothesis of the proposed project is that after a fat overload, the postprandial response is different in both groups, suggesting that the lpp will present the most significant damage in endothelial vasomotion in obese individuals, especially those with gi and t2dm. after the fat overload, we hypothesized that there will be a worsening of endothelial function and microvascular reactivity in ob/dm2 and ob group compared to c, but also find lower concentrations of incretins in ob/dm2 group compared to other groups. these hypotheses may be confirmed by techniques for evaluating microvascular function, the use of dft skin for vasomotion evaluation and finally analysis of analytes through metabolic and cardiovascular read by multiplex kit.

will be recruited 60 women aged 19-40 years, with a diagnosis of obesity (bmi ≥ 30 kg/m2) treated at the obesity clinic at the state university of rio de janeiro (uerj)at brazil. microcirculation parameters and blood tests will be assessed at baseline and after this, the women will receive a high-fat meal containing croissant, salami, whole milk and cheddar cheese. after 30, 60, 120 and 180 minutes this meal the microcirculation will be evaluated as well as blood collection.

Eligibility criteria:
inclusion criteria: * all patients should have obesity class i (bmi between 30 and 35kg/m2); * submit diabetes mellitus without further treatment or be obese non-diabetic or glucose intolerant; * presenting the age between 19 to 40 years. * waist circumference\> 80 cm (idf) exclusion criteria: * renal disease, coronary or peripheral vascular, hematologic or hepatic impairment; * presence of dyslipidemia; * smokers; * significant loss of body weight six months prior to the study.

Keywords: glucose intolerance (20) control (20)
myocardial function of the setonis aortic valve before and beyond valve replacement

Conditions: Myocardial Function of the Stenosis Aortic Valve Before and Beyond Valve Replacement

Summary: study the consequences on heart muscle of the stenosis aortic valve before and after the replacement procedure, the repercussion on heart. study the impact on the heart of "sick" valve can affect on "well-being" and prognosis in the year following the surgery.


Eligibility criteria:
inclusion criteria: * major patient freely accepting to participate in the study * non-opposition signed * aortic surface \<1cm² or \<0.6cm² / m² of indication surgical restraint * oriented to short interventional management surgical term * lvef left ventricular ejection fraction\> 50% * in the subgroup "mri-fibrosis", absence of indication for performing mri exclusion criteria: * patient under guardianship, curatorship or safeguard of justice * minor patient * pregnant woman * patient with significant polyvalvulopathy for which it is from the start programmed more than aortic valve replacement * patient with severe coronary artery disease requiring revascularization * allergy to the contrast product
interest of mri in preoperative staging for the laryngeal and hypopharyngeal cancer

Conditions: Hypopharyngeal Carcinoma; Laryngeal Carcinoma

Summary: to determine if mri can detect preoperative invasion of cartilage by laryngeal and hypopharyngeal carcinoma, and to compare it to ct imaging and histopathology in excised larynges and/or hypopharynges.


Eligibility criteria:
inclusion criteria: * patient ≥18 years old * patient with a laryngeal or hypopharyngeal cancer at any stage * patient eligible for a surgical treatment in multidisciplinary consultation * patient who did not oppose its participation to the study * indication for performing an mri in addition to ct at the discretion of the investigator exclusion criteria: * patient with an asa ("american society of anesthesiologists", international anesthesia classification) score ≥ 3, * patient with a chirurgical contraindication * patient with a mri contraindication * pregnant or nursing woman * adult requiring protection (guardianship, supervision) * patient participating in interventional research (excluding physiological studies and interventional research involving only minimal risks and constraints that do not interfere with the analysis of the primary outcome).
picu patient diary

Conditions: Critical Illness

Summary: the picu-diary study is a prospective single centre pilot study in the pediatric critical care unit at mcmaster children's hospital. we will evaluate the impressions of family caregivers and healthcare providers on the picu patient diary, and its acceptability for use in the picu, using mixed methods. we will assess the feasibility of assessing the impact of a patient diary on picu outcomes and psychological distress in critically ill children, 1 month following picu discharge.

there is considerable need for research dedicated to exploring interventions to improve the psychological and functional effects of critical care admission on patients and families. patient diaries are one approach that has been used in several adult critical care groups and has been shown to positively impact patient care by helping patients better understand their illness, acting as a therapeutic tool and debriefing aid, and providing an outlet for caregivers to participate in care plans. however, to date, there is minimal research available in the pediatric population. the specific objectives of this study are to evaluate the acceptability and impressions of a patient diary as a supportive measure for critically ill children in the picu. our secondary objective is to evaluate the feasibility of measuring the impact of a patient diary on psychological distress in critically ill children, following discharge from the picu. the purpose of this diary is to support the recovery of critically ill children and their family members by: 1. helping patients understand visually and in written form as age appropriate, what has happened to them during their picu stay, how ill they were, and in so doing, reduce anxiety and post-traumatic stress symptoms; and 2. serving as an engagement tool to help families take on an informed, active role in their child's care plan.

Eligibility criteria:
inclusion criteria: * consecutive patients admitted to the picu will be screened for eligibility to participate in the evaluation component of the picu diary study * we will offer a picu diary to families of any critically ill children admitted to the picu for at least 72 hours and who are fluent in the english language * eligible patients and their families will be approached for consent to participate, by a member of the investigator team (mb, kc, sb or cc). for those who consent to participate, they will be oriented to the diary and its use. exclusion criteria: * stay less than 72 hours * not fluent in the english language
genlab: unveiling the genetic landscape of brugada syndrome: novel biomarker discovery for precise diagnosis

Conditions: Brugada Syndrome (BrS)

Summary: this research makes several significant contributions to the field of brs. it employs advanced genetic sequencing techniques to develop a genetic signature to improve the accuracy and efficiency of brs diagnosis. the identification of specific biomolecular profiles and genetic signatures enhances our understanding of the syndrome's molecular mechanisms, facilitating targeted therapies and refined risk stratification. these advancements optimize patient care by enabling personalized treatment plans and risk assessment. overall, this research adds value by advancing diagnostic methods, providing molecular insights, optimizing patient care, and positively impacting public health outcomes in brs.

our work on brs is dedicated to decipher the pathogenic mechanism and to ameliorate diagnostic approaches by developing a non-invasive test. employing a multi-omic strategy, we've identified potential biomarkers across proteins, metabolites, and lipids, leading to a filed patent for a promising biomolecular signature. additionally, we've discovered associated gene mutations. this grant proposal aims to enhance our preliminary findings by studying a larger brs cohort, supported by a meticulously curated patient registry. by integrating advanced whole-exome sequencing (wes) and machine learning , we aim to identify a genetic signature for brs diagnosis and uncover altered pathways integral to brs etiology. this could refine risk stratification strategies, contributing to improved diagnostic accuracy and deeper understanding brs molecular mechanisms.

Eligibility criteria:
inclusion criteria: * age \> 18 years * patients affected by brugada syndrome * patients who signs the informed consent exclusion criteria: * none
study of liatermin (r-methugdnf) administered by bilateral intraputaminal (ipu) infusion to subjects with idiopathic parkinson's disease

Conditions: Idiopathic Parkinson's Disease

Summary: this randomized study was designed to evaluate the efficacy and safety of ipu-infused liatermin (15mg/putamen/day) compared with placebo in subjects with symptomatic, levodopa-response parkinson's disease. this study consisted of a 90-day evaluation period followed by implantation of the ipu delivery system and then a 6-month double-blind treatment period.


Eligibility criteria:
inclusion criteria: - diagnosis of bilateral, idiopathic parkinson's disease

Keywords: bilateral, idiopathic parkinson's disease
electroacupuncture for hypertension patients with chronic kidney disease

Conditions: HYPERTENSION RENAL

Summary: 1. to observe the efficiency of electroacupuncture for hypertension patients with chronic kidney disease. 2. to observe if different-time treatment having an impact on hypertension patients with chronic kidney disease.


Eligibility criteria:
inclusion criteria: * chronic kidney disease patients with hypertension exclusion criteria: * renal replacement therapy * heart failure * severe valvular disease * sustained arrhythmias * secondary hypertension excluded from renovascular hypertension * acute cardiovascular events * infection
use of dual energy computed tomography in thoracic radiotherapy planning.

Conditions: Lung Cancer; Lung Function Decreased; Radiation Pneumonitis

Summary: this is a prospective observational study aiming: 1) to quantify lung function using perfusion dual energy computed tomography (dect) and use this information at the time of treatment planning with preferential sparing of functional lung parenchymal 2) to validate results of lung function obtained using dect with lung perfusion scintigraphy results, the current standard method; 4) to compare dosimetry of whole lungs vs. functional lungs in patients treated with either stereotactic body radiotherapy (sbrt) for early stage lung cancer or conventional radiotherapy for locally advanced lung cancer and 5) to evaluate lung function 6, 12 and 24 months post-radiotherapy with both perfusion dect and pulmonary function tests and compare radiation dose-map to functional lung-map.


Eligibility criteria:
inclusion criteria: * ≥ 18 years * ecog 0-2 * pulmonary neoplasia, confirmed histopathologically or by imaging * prognosis evaluated ≥ 1 year by attending md * clinically acceptable lung capacity to undergo radiotherapy * initial assessment including history, physical examination, biochemistry, pft, chest radiograph, chest and abdominal-pelvic scan, pet * written consent * the patient must be available for treatment and monitoring. patients registered in the study should be treated in our center. exclusion criteria * previous radiotherapy in the radiation field * presence of any major medical condition that, in the opinion of the investigator, would prevent follow-up at 6, 12 and 24 months post-radiotherapy. * iodine allergy * pregnancy and lactation
the effect of distraction technique on children's pain, anxiety and fear of medical procedure in invasive interventions

Conditions: Child Behavior

Summary: this study was conducted on the effects of visual and/or auditory distraction techniques applied to children aged 7-12 years who applied to çanakkale mehmet akif ersoy state hospital gynecology and pediatric emergency service during invasive procedures (blood sampling, intravenous access or intramuscular injection in the deltoid region). kaleidoscope, music concert, virtual reality glasses) is a randomized controlled experimental study to determine the effect of children on pain, anxiety and fear of medical procedures.


Eligibility criteria:
inclusion criteria: * the child is between the ages of 7 and 12 * admission of the child to the pediatric emergency service for diagnosis and treatment * the child's general condition is stable * deciding on one of the interventions such as blood collection, vascular access, deltoid region intramuscular injection after the examination, and the absence of any other invasive intervention planning * the fact that the invasive intervention was performed in one go * the child does not have vision and hearing problems * the child has no pain (due to the disease, drug side effects, distension) * the child does not have a chronic disease (kidney, diabetes, etc.) that will require frequent invasive procedures. * the child's mental development level to be able to answer the questions asked * the child and parent speak and understand turkish comfortably * the children and their parents are willing to participate in the research. * parents give written consent exclusion criteria: * the child has a history of epilepsy, vertigo and neurological disease * having a history of fainting during blood draw * having a disease that causes chronic pain * wearing glasses or hearing aids * complication development during invasive intervention (allergy, syncope, etc.) * if the child is in danger of life and is taken to the very urgent patient examination room (resuscitation room) * deciding that the child is a forensic case after the examination

Keywords: music kaleidoscope virtual reality glasses