Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of shexiang baoxin pill in patients with ischemia with non-obstructive coronary artery

Conditions: Ischemia With Non-Obstructive Coronary Artery; Angina Pectoris; Coronary Heart Disease; X Syndrome, Angina

Summary: this is a multicenter, randomized, double-blind, placebo-controlled clinical trial. patients were treated with the trial drug or placebo in a 1:1 ratio. the control group was treated with placebo 4 pills / day, 3 times / day on the basis of conventional treatment until the end of follow-up, while the experimental group was treated with musk pill 4 pills / day, 3 times / day on the basis of conventional treatment until the end of follow-up.


Eligibility criteria:
inclusion criteria: * the age was 18-75 years old, and the gender was not limited; * the clinical diagnosis of angina pectoris or angina pectoris equivalent symptoms (attack at least twice a week), within 1 year, coronary cta or coronary angiography examination of coronary artery normal or lesions \< 50%; * willing to follow up and sign informed consent. exclusion criteria: * patients were selected and had no angina pectoris without medication * history of vascular reconstruction within 6 months, cabg or pci; * preparation for cabg or pci during the trial period * the maximum lesions of major branches of major vessels were ≥ 50% in cta or angiographic examination; * severe cardiovascular and pulmonary vascular diseases: stubborn heart failure or cardiogenic shock, hypertrophic obstructive cardiomyopathy, severe aortic stenosis, incomplete closure, aortic dissection, pulmonary embolism; * there were three months of acute myocardial infarction; * severe respiratory disease, copd or active pulmonary infection; * although the patients with poor blood pressure control were treated with hypertension, the hypertension was not controlled and / or systolic pressure ≥ 180mmhg and diastolic pressure ≥ 110mmhg before the end of screening period; * severe liver and kidney diseases, such as liver and kidney dysfunction (alt, ast ≥ 1.5 times of the upper limit of normal value, cr \> 1.5 times of normal value), active liver disease, cirrhosis or uremia patients; * any other serious diseases or conditions such as malignant tumor, severe anemia, severe renal artery stenosis, severe anxiety depression (hamd-17) and suicide or maniac mental illness; * participated in other clinical studies within 30 days before the selection, or is currently participating in other clinical studies; * pregnant, lactating women and women and men with recent birth plans; * allergic constitution or allergy to known components of the study drug; * the researchers judged that the patients who were not suitable for the study were not suitable. (note: patients need to stop using other cardiovascular traditional chinese patent medicines and simple preparations or traditional chinese medicine for 7 days before enrollment.)

Keywords: shexiang baoxin pill muskardia patients with chest pain due to non obstructive coronary artery disease
comparing acceptance and commitment therapy (act) and cognitive therapy (ct) for test anxiety

Conditions: Anxiety

Summary: this study proposes to compare the effectiveness of an acceptance-based intervention and a cognitive control-based intervention for coping with test anxiety in nursing students during the hesi (health education systems, inc.) examination. subjects will be randomized to receive either the ct or the act condition. in both conditions, subjects will receive an education on test anxiety to inform them about what test anxiety is and why it occurs. then, the different conditions will receive the respective treatment of either ct or act. the study is considered minimum risk because the nursing students will only be exposed to an amount of anxiety that is typical of their testing experience. both conditions will meet three times, with each session lasting approximately one and a half hours. the purpose of the treatment is to provide subjects with tools to help them cope with their test anxiety.


Eligibility criteria:
inclusion criteria: * nursing student subjects may only participate if they are currently enrolled as an undergraduate student at drexel university. * they must be nursing majors enrolled in nursing 492 and intending to take the cumulative hesi examination. * psychology students must be enrolled in the courses where recruitment will occur. * pre-professional students must be currently enrolled at drexel university, and planning to take a standardized test within 6 months. * all subjects must be at least 18 years of age or older. exclusion criteria: * persons may not participate if they are unable to see/read words off of a computer screen.

Keywords: test anxiety
comparison of corwatch with right heart catheter measurements in heart failure

Conditions: Heart Failure

Summary: this is an observational study to evaluate the agreement between the incardia diagnostic technology corwatch for the assessment of venous pressure in human subjects. this includes evaluation of incardia technology in heart failure (hf) patients undergoing invasive right heart catheterization in a cardiac catheterization laboratory (cath lab) and in a cardiac intensive care unit (icu).


Eligibility criteria:
inclusion criteria: * diagnosed with nyha class ii-iv heart failure irrespective of ejection fraction * patient is able to give consent exclusion criteria: * severe tricuspid regurgitation * mechanical ventilation * patient is pregnant * inability to access either of the patient's upper arms.

Keywords: central venous pressure right heart catheterization hemodynamic congestion
a comparison of three medications to treat diarrhea in adults.

Conditions: Diarrhea

Summary: a comparison of three medications to treat diarrhea in adults.

this single (investigator) blind, randomized, 3-arm, parallel-group study design was selected to show non-inferiority of loperamide/simeticone caplets compared to chewable tablets in a heterogeneous subject population aiming at validity of results and reducing bias. the study will also compare the loperamide/simeticone combinations versus a probiotic (saccharomyces boulardii) in the treatment of acute diarrhea in adults. probiotics have been used for acute infectious diarrhea to reduce the duration and severity of the illness.

Eligibility criteria:
inclusion criteria: * male or female at least 18 years of age * acute diarrhea illness with symptoms onset within 48 hours of study entry * minimum of 3 unformed stools in 24 hours before study entry * most recent stool is unformed * abdominal discomfort/wind (intensity mild to severe) within 4 hours of study entry * women of childbearing potential must have a negative pregnancy test at screening * willing to adhere to the prohibitions and restrictions specified in this protocol * subjects must have signed an informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study exclusion criteria: * requiring hospital admission, parenteral hydration or antibiotic therapy axillary temperature \>38.2°c or oral temperature \>38.6°c * history or clinical evidence of gross blood or pus in stool in current illness * signs or symptoms of orthostatic hypotension * unable to take medication and fluids by mouth * history of chronic gastrointestinal disease, hepatic or renal insufficiency, or other significant medical condition that could be aggravated by untreated acute diarrhea * immunodeficiency (e.g. those with acquired immunodeficiency syndrome \[aids\] or known human immunodeficiency virus \[hiv\] infection, or undergoing chemotherapy or radiotherapy) * intake of antibiotics, oral antifungals, quinidine or ritonavir within 7 days, antidiarrhoeal, promotility drugs (e.g., metoclopramide, domperidone), antiflatulents (e.g., simeticone, activated charcoal) or probiotics or bismuth salts within 48 hours, or any analgesic within 6 hours prior to study entry hypersensitivity to loperamide, yeast, or any component of study formulations * pregnant or breast-feeding * unable to comply with the protocol requirements and schedule * any condition that, in the opinion of the investigator, would compromise the well-being of the subject or the study * use of opiates (as 'recreational' drugs and as painkillers)

Keywords: antidiarrheals
evaluating an internet-based program for anxious youth: a pilot rct

Conditions: Anxiety

Summary: anxiety is a common mental health problem for canadian youth. anxiety that is diagnosed as a disorder and serious enough to require treatment affects up to 10% of all youth by the age of 16. anxiety disorders can have serious negative effects on a young person's personal relationships, school performance, and family life. these disorders may not be discovered by youth, parents and health care providers. even if anxiety disorders are discovered, youth may not get the right therapy. anxious youth can become sick if their anxiety is not treated properly. the investigative team will carry out research to test breathe, their new internet-based treatment for youth with anxiety problems. youth can use this treatment at home. breathe includes information materials and personalized homework assignments to help anxious youth learn ways to manage anxiety. this study is a pilot randomized controlled trial (rct) with two groups, an internet-delivered cognitive behavioural therapy (cbt) experimental group (breathe) and a resource webpage (control group; considered treatment as usual for youth waiting for services). the investigators will evaluate several methodological processes and outcomes through the following objectives: 1. to evaluate the change in youths' anxiety (primary outcome) from pre- to post- intervention. 2. to estimate recruitment and retention rates for a full-scale rct. 3. to estimate a sample size for a full-scale rct. 4. to define the minimal clinically important difference (mcid) for the primary outcome measure. 5. to measure intervention acceptability. 6. to determine the use of co-interventions during the trial. 7. to conduct a preliminary economic analysis.


Eligibility criteria:
inclusion criteria: * dsm-iv social anxiety, generalized anxiety, anxiety not otherwise specified, or adjustment disorder as the primary clinical problem * ability to read and write english * regular access to a telephone and a computer system with high speed internet service * ability to use a computer to interact with web material * youth aged 13-14 must have a consenting parent exclusion criteria: * youth with an anxiety problem that is not included above * youth who receive cognitive behavioural therapy * youth who cannot provide consent
moderating impact of various emotion personality factors on salivary cortisol response to a tsst

Conditions: Psychological Stress

Summary: with the aim of evaluating the putative impacts of emotion related personality factors on physical and mental disease and the mechanisms of these impacts, 58 students were submitted to a social stress test (trier social stress test) and salivary cortisol samples were taken. the subjects were also submitted to several personality trait inventory, that evaluated respectively alexithymia, emotional intelligence, resilience and the five factor model of personality. the moderating impact of these factors on the cortisol response were analysed


Eligibility criteria:
inclusion criteria: * students exclusion criteria: * female, * smokers, * medication or alcohol abuse

Keywords: emotion personality social stress appraisal
mucosal microbiome in human gastric intestinal metaplasia and duodenal tissue.

Conditions: Mucosal Microbiome; Gastric Intestinal Metaplasia; Duodenum

Summary: to investigate the mucosal microbiome in human gastric intestinal etaplasia and duodenal tissue.


Eligibility criteria:
inclusion criteria: * patients scheduled for gastroendoscopy examination aged between 18 and 80 years old exclusion criteria: * antibiotic, probiotic or prebiotic usage within 2months,gastric inhibitor usage within 1 month esophageal, gastric or duodenal cancer or other malignancy history of upper gi tract surgery coagulopathy or bleeding disorders allergy to fluorescein sodium pregnant or breast-feeding (for females) impaired renal function

Keywords: mucosal microbiome gastric intestinal metaplasia duodenum
hypofractionated radiotherapy for prostate cancer

Conditions: Prostate Cancer

Summary: radiotherapy is a standard definitive treatment for men with localized prostate cancer. recent improvements in technology allow high doses of radiation to be delivered to the prostate in less days with lower doses to surrounding healthy tissues, trying to reduce side effects. this study is being proposed to evaluate the use of moderate hypofractionated volumetric radiotherapy in localized prostate cancer patients and assessing treatment -related later adverse events using the ctcae 4.0

recent evidence suggests that the same or better outcomes might be achieved in prostate cancer by ussing a higher dose of radiation per fraction ( 3gy) with the consequent decrease in total days quality of life outcomes as well as gastrointestinal and genitourinary late toxicities will be analyzed. it is thought that this regimen will produce comparable findings and would result in substantial health care cost savings, as well as, be more convenient for patients.

Eligibility criteria:
inclusion criteria: * histologic confirmation of adenocarcinoma of the prostate by biopsy * performance status 0-2 * signed informed consent form exclusion criteria: * positive lymph-nodes or metastatic disease from prostate cancer on imaging studies * anticoagulant treatment, individual assessment of antiplatelet therapy * previous pelvic radiotherapy * previous surgery for prostate cancer * previous transurethral resection of the prostate * history of crohn's disease or ulcerative colitis * antecedents of rectal fistulas in the last 10 years * previous significant urinary obstructive symptoms * previous chemotherapeutic treatments * non-compliance with constraints established in this protocol (see special section

Keywords: hypofractioned
sexual behavior among medical students in mexico

Conditions: Sexually Transmitted Diseases

Summary: this study aims to identify factors that influence students to undertake or not sexually transmitted diseases screening tests and to have an actual outlook of how mexican university students live their sexual life. moreover, the investigators aim to identify potential epidemiological risks and challenges to achieve adequate prevention and control of sexually transmitted diseases in this population. this is a descriptive cross-sectional study conducted at a private university in guadalajara, jalisco, mexico, from december 2019 to april 2020.

the investigators will invite the students to complete it and leave it in a black painted box to maintain privacy. the investigators will inquire if the participants considered having adequate knowledge about stds, sexual intercourse onset, sexual behavior, number of sex partners, sexual orientation, use of condoms and contraceptives, sexual intercourse under the influence of alcohol or drugs, and reasons why students do not get sexually transmitted diseases screenings.

Eligibility criteria:
inclusion criteria: * university students currently attending medical school from 1st through 6th semester exclusion criteria: * young adults not attending medical school * students out of the 1st - 6th-semester range

Keywords: sexually transmitted diseases mass screening public health confounding factors sexual intercourse epidemiologic
post-operative pain and child behavior of hall technique versus sdf in the management of carious primary molars: rct

Conditions: Caries

Summary: pico question: papulation: children suffering from caries intervention: silver diamine fluoride comparison: hall technique outcome: primary outcome: intraoperative and postoperative pain measurement device: face pain scale revised8 measurement unit: score 0-2-4-6-8-10 secondary outcome: 1. child anxiety measurement device: venham anxiety rating scale 9 measurement unit: six-point scales 0-1-2-3-4-5 2. child behavior measurement device: venham behavior rating scale 9 measurement unit: six-point scales 0-1-2-3-4-5

dental caries, also known as tooth decay, it can occur in primary teeth in early childhood, is formed through interaction between acid-producing bacteria and carbohydrate. the caries develops in both the crowns and roots of teeth. progress of caries depended on the lifestyle of the child (as high numbers of cariogenic bacteria, inadequate salivary flow, insufficient fluoride exposure and poor oral hygiene). to avoid this disease should follow the proper oral hygiene and improve lifestyle 1. a lot of methods found to treatment the decayed tooth - like; hall technique and silver diamine fluoride. the first report on the hall technique published in 2007 by a general dental practitioner from aberdeen/scotland, dr. norna hall. dr. hall used pmcs to restore carious primary molars rather than using the standard technique, placed them using a simplified method2. previous studies have recommended that silver diamine fluoride (sdf) solution would exert a preventive result in managing early childhood caries ecc. however, no well-designed clinical trials have yet been performed to study the effect of sdf on caries prevention. the objective is useful in arresting early childhood caries (ecc) 3

Eligibility criteria:
inclusion criteria: 1. age: from 4 to 6 years 2. clinical diagnosis of tooth with caries in primary molars within enamel or dentin without pulp disease exclusion criteria: 1. tooth with signs and symptoms of pulp necrosis 2. tooth with root caries 3. tooth with spontaneous pain
memflex to prevent depressive relapse

Conditions: Major Depressive Disorder

Summary: a wealth of research has demonstrated that they way in which the investigators recall our personal, autobiographical memories is influential in the course of depression. biases in the recall of autobiographical memory occur in the midst of a depressive episode, and are shown to prolong symptoms, however these biases also remain when depression remits, and may predispose the individual towards relapse. a novel cognitive intervention, memflex, aims to train individuals to be flexible in their retrieval of autobiographical memories, and thereby reduce depressive relapse. changes in memory bias may also have an effect on intermediate processes that increase risk of depression, such as rumination, impaired problem solving, and cognitive avoidance. this feasibility trial compares the effects of memflex and psychoeducation in their ability to reduce memory bias and intermediate cognitive risk factors, and thereby depressive relapse, in individuals remitted from major depressive disorder. clinical outcome and process measures will be assessed immediately following completion of the intervention, at 6 months post-intervention, and at 12 months post-intervention. if encouraging, the results of this pilot trial may provide a foundation for a later phase trial.


Eligibility criteria:
inclusion criteria: * meets criteria for major depressive disorder but is currently in remission, indexed on the structured clinical interview for the dsm (scid; first et al., 1996) * 18 years of age or older exclusion criteria: * meets criteria for a current major depressive episode, indexed on the scid * meets criteria for another mood disorder (e.g., bipolar disorder), indexed on the scid * current alcohol or substance dependence, or currently experiencing psychotic symptoms, indexed on the scid * experience of intellectual disability, traumatic brain injury, or other neurological condition which may impact memory recall, assessed via self-report

Keywords: depression cognitive risk factors autobiographical memory cognitive bias relapse prevention
immune response following lobectomy along with or without bilateral transcervical mediastinal lymphadenectomy

Conditions: Lung Neoplasm Malignant

Summary: any kind of anatomical lung resection for lung cancer with curative intent has to be accompanied by formal mediastinal lymph node dissection. video-assisted mediastinoscopic lymphadenectomy through a cervical access (vamla) along with thoracoscopic lobectomies in the same setting offers improved radicality through bilateral mediastinal dissection, provide accurate staging, does not require single lung ventilation and hence ideally supports the concept of minimally invasive surgery. due to the vamla associated radicality, the investigator believes that using of vamla along with lobectomy could improve the oncological outcome of lung cancer patients. furthermore, the absence of single lung ventilation during vamla could attenuate the surgically induced immunosuppression.

any kind of anatomical lung resection for lung cancer with curative intent has to be accompanied by formal mediastinal lymph node dissection. video-assisted mediastinoscopic lymphadenectomy through a cervical access (vamla) along with thoracoscopic lobectomies in the same setting offers improved radicality through bilateral mediastinal dissection, provide accurate staging, does not require single lung ventilation and hence ideally supports the concept of minimally invasive surgery. due to the vamla associated radicality, the investigator believes that using vamla along with lobectomy could improve the oncological outcome of lung cancer patients. furthermore, the absence of single lung ventilation during vamla could attenuate the surgically induced immunosuppression. the present study aims at: 1. the current project primarily aims at identifying the effect of reduced single lunge ventilation time during vamla-vats lobectomy on the intraoperative production of oxygen radicals as well as its effect on the immune competence of patients undergoing vamla-vats lobectomy as compared to those receiving vats lobectomy along with conventional unilateral lymphadenectomy. 2. secondary, in line with the hypothesis that radical bilateral lymphadenectomy might results in a more complete oncological staging as compared to unilateral lymphadenectomy or lymph node sampling. the current project aims to compare the pre- and postoperative staging in patients undergoing vamla, as vamla enables a proper examination of all bilateral mediastinal lymph nodes. 3. patient follow-up will be continued for at least 5 years postoperatively in order to compare the oncological outcome namely local and distant recurrence, tumor-associated and overall survival in patients undergoing vamla-vats lobectomy as compared to those with vats lobectomy. this issue is, however, a second endpoint of this study and will be independent of the primary endpoint.

Eligibility criteria:
inclusion criteria: * adult * non small cell lung cancer * operable tumor * indicated for endoscopic lung surgery exclusion criteria: * pregnancy

Keywords: lung lobectomy lymphadenectomy