Kornimate/medical-research-clean huggingface dataset:
the role of gastroesophageal reflux in scleroderma pulmonary fibrosis

Conditions: Interstitial Lung Disease; Systemic Sclerosis; Gastroesophageal Reflux

Summary: scarring of the lungs is common in patients with scleroderma and is one of the main causes of death. patients with scleroderma very frequently have problems with their gullet (esophagus), the food pipe that leads into the stomach. normally, a small circular muscle at the base of the esophagus opens to allow food to pass into the stomach and closes to keep the digestive fluids from flowing back up into the gullet. in patients with scleroderma, the muscle may become weak and no longer close properly. gastroesophageal reflux (ger) is the medical term for reflux of stomach contents into the esophagus. our hypothesis is that small amounts of ger can move back up into the esophagus and get inhaled into the lungs, and may be one of the triggers for lung scarring. we propose to look for certain substances normally only found in the stomach in the "exhaled breath condensate" which is collected by breathing comfortably into a cooled cylinder, allowing the breath to condensate. in a smaller group of patients, we also plan to perform a bronchoalveolar lavage, a more widely studied test in which a small amount of fluid is introduced into a small part of the lungs through a fine tube, and then removed for examination, to evaluate whether the two tests provide similar measurements. we will also evaluate the correlation between these molecules and other tests, including lung function, and markers of lung scarring activity, and tests to look at how the esophagus is working so that we can get a clearer picture of how this affects patients' daily lives. finally, we will be following up patients over time with lung function to see whether evidence of ger into the lungs is linked with a greater likelihood of worsening of lung scarring in the future.


Eligibility criteria:
inclusion criteria: * patients aged \> 18 years * diagnosis of ssc (american college of rheumatology criteria) * interstitial lung disease (\>5% extent of ild on hrct) * only for bronchoscopy: presence of troublesome cough and/or ger symptoms and/or recurrent chest infections and/or asymmetry of ild changes on ct exclusion criteria: * significant communication difficulties * unable to perform reliable lung function tests * current smokers * only for bronchoscopy: fev1 less than 1l or dlco less than 30% of the predicted
polyunsaturated fatty acids in patients with nafld.

Conditions: NAFLD

Summary: patients with metabolic syndrome and nonalcoholic fatty liver disease (nafld) will be randomly allocated for the treatment with n-3 pufa (3.6 g/day) or placebo for 12 months. at the beginning and at the end of the study basic clinical and anthropometric data, as well as parameters of liver steatosis and fibrosis will be tested.

patients with metabolic syndrome and nonalcoholic fatty liver disease (nafld) will be randomly allocated for the treatment with n-3 pufa (3.6 g/day) or placebo for 12 months. at the beginning and at the end of the study basic clinical and anthropometric data will be recorded and the following parameters will be tested: panel of biochemistry and liver function tests: triglycerides, cholesterol, hdlcholesterol, ldl-cholesterol, glucose, insulin, serum bilirubin, liver tests, thyroid hormones, bile acids and their metabolites, albumin, total protein. bioactive metabolites, inflammatory markers non-invasive serum markers of liver fibrosis and steatohepatitis. hyaluronic acid, nafld fibrosis score, cytokeratine-18 fragments. ultrasonography with non-invasive measurement of fibrosis and steatosis, magnetic resonance spectroscopy for visceral and liver fat determination.

Eligibility criteria:
inclusion criteria: * patients with metabolic syndrome and nafld exclusion criteria: * age below 18 years * gravidity * incompliance.
23andme ipf research study

Conditions: Idiopathic Pulmonary Fibrosis

Summary: the long term goal of this study is to increase genetic understanding of ipf to enable the development of an effective drug for ipf that can improve the lives of those living with the condition.

this study will recruit 1,000 people who have been diagnosed with ipf or hermansky-pudlak syndrome (hps). eligible participants who consent to participate in 23andme research and the ipf research study will receive a 23andme health + ancestry kit at no cost. participants will provide a saliva sample and take a baseline survey online answering questions about their disease diagnosis, testing, treatment, and symptoms. participants will also be asked to take the same survey 3, 6, and 9 months after completing the baseline survey. the data collected from this study will be incorporated into the 23andme database and used to better understand the underlying genetic and environmental factors that contribute to ipf.

Eligibility criteria:
inclusion criteria: * have been diagnosed with ipf or hermansky-pudlak syndrome (hps) * are 18+ years old * live in the us exclusion criteria: - have been diagnosed with sarcoidosis or hypersensitivity pneumonitis

Keywords: idiopathic pulmonary fibrosis ipf pulmonary fibrosis lung diseases lung respiratory tract diseases rare rare diseases hermansky-pudlak syndrome hps
retrospective study on the prediction of radiation-induced brain injury in patients with nasopharyngeal carcinoma

Conditions: Nasopharyngeal Carcinoma; Radiation-Induced Temporal Lobe Injury

Summary: radiation therapy has become the preferred treatment for nasopharyngeal cancer due to the sensitivity of nasopharyngeal carcinoma to radiation. however, even with the use of intensity-modulated radiation therapy (imrt), radiation-induced temporal lobe injury (rtli) can be a severe complication. patients with rtli may experience long-term memory loss, personality changes, physical dysfunctions, and other symptoms, which seriously impair their quality of life and long-term prognosis. currently, the diagnosis of rtli primarily relies on clinical symptoms and imaging examinations such as computed tomography (ct) and conventional mri. however, these methods only enable the diagnosis of rtli at a late stage when it is irreversible and cannot be effectively treated. therefore, the early identification or individualized prediction of rtli after imrt holds exceptional importance for improving the quality of life in nasopharyngeal carcinoma patients. the exact mechanism of rtli remains unclear. many clinical covariates have been proven to be associated with rtli in npc patients, including stage, age, and dosimetric parameters. in addition, it was reported that each patient's temporal lobe exhibits unique genetic susceptibility to radiation exposure. in this study, we aim to predict the occurrence of rtli by analyzing clinical factors and heterogeneity of temporal lobe tissue prior to irradiation. finally, we want to construct and validate a prediction model for rlti, which can support clinician decision-making in developing individualized treatment plans and providing preventive measures.


Eligibility criteria:
inclusion criteria: * (1) pathological confirmation of npc; (2) receipt of imrt; (3) nasopharynx-neck mri within 2 weeks before antineoplastic treatment exclusion criteria: * (1) temporal lobe invasion; (2) with central nervous system diseases except rtli; (3) receiving additional radiation after imrt; (4) incomplete clinical or imaging data

Keywords: radiomics machine learning deep learning
dynamic change in accommodation after wearing multifocal soft contact lenses for myopia control

Conditions: Myopia; Accommodation

Summary: the purpose of this study is to report the changes in accommodation, aberrations, and myopia in patients wearing multifocal soft contact lens for various durations. the study objectives are to: 1. determine the effects of wearing multifocal soft contact lens on accommodation and aberrations over a 12-month period. 2. determine the effect of wearing multifocal soft contact lens on myopia over a 12-month period.


Eligibility criteria:
inclusion criteria: * age: 8-17 years * refractive error: sphere ≤ -10.00d, cylinder ≤ 1.00d * monocular bcva 20/25 or better * no previous cl experience required exclusion criteria: * history of ocular pathology, binocular vision anomalies, refractive surgery, previous myopia control therapy, pharmaceutical agent known to affect accommodation.
paclitaxel eluting balloon and conventional balloon for in-stent restenosis of the superficial femoral artery

Conditions: Peripheral Vascular Disease

Summary: the aim of this study is to perform a randomized, controlled trial to compare percutaneous transluminal angioplasty using paclitaxel eluting balloon (peb) or using a conventional balloon for treatment of superficial femoral artery in-stent restenosis.

the superficial femoral artery is a common place for arteriosclerosis in patients symptomatic for lower extremity vascular disease. advances in percutaneous transluminal angioplasty (pta) and stenting have provided new options for the treatment of the disease in this arterial segment. restenosis after pta occurs in 40-60% within one year. a novel attempt to reduce restenosis is the use of paclitaxel eluting balloons (peb). first clinical studies suggest that the use of pebs during percutaneous treatment of femoropopliteal disease is associated with significant reductions in late lumen loss and target-lesion revascularization. there is no randomized comparison of these treatments in patients with in stent restenosis of the superficial femoral artery. thus, the aim of this study was to compare the efficacy of pta with conventional balloon or peb for in stent restenosis in the sfa in terms of reduction of diameter stenosis at follow-up angiogram.

Eligibility criteria:
inclusion criteria: * symptomatic ≥ 70% in-stent restenosis of the afs, (rutherford stage 2-6) * written, informed consent by the patient or her/his legally-authorized representative for participation in the study exclusion criteria: * acute ischemia and/or acute thrombosis of the sfa * untreated ipsilateral iliac artery stenosis \>70% * not at least one vessel run-off * popliteal involvement with stenosis \>70% * severe renal insufficiency (gfr \<30 ml/min/m2) * malignancies or other comorbid conditions (for example severe liver, renal and pancreatic disease) with life expectancy less than 12 months or that may result in protocol non-compliance. * pregnancy (present, suspected or planned) or positive pregnancy test. * previous enrollment in this trial. * patient's inability to fully cooperate with the study protocol.

Keywords: pta paclitaxel restenosis
massachusetts general hospital and tsuchiura kyodo general hospital coronary imaging collaboration

Conditions: Atherosclerosis

Summary: the purpose of this collaboration is to establish a multi-modality image database including coronary angiograms, optical coherence tomography (oct), computed tomography angiograms (cta) and cardiac magnetic resonance imaging (cmr) for future studies. the main goal of this collaboration is to create a resource to promote further understanding of the pathobiology of atherosclerosis through image analysis.

the purpose of this collaboration is to establish a multi-modality image database including coronary angiograms, optical coherence tomography (oct), computed tomography angiograms (cta) and cardiac magnetic resonance imaging (cmr) for future studies. about one thousand patients who underwent coronary angiography with oct and had a cta prior to catheterization at tsuchiura kyodo general hospital (tkgh) in japan, will be included. a subset of these patients also had cmr. the main goal of this collaboration is to create a resource to promote further understanding of the pathobiology of atherosclerosis through image analysis.

Eligibility criteria:
inclusion criteria: * had cta prior to cardiac catheterization and then oct during catheterization exclusion criteria: -
dietary fiber: is it the missing link in achieving long term behavior change?

Conditions: Obesity

Summary: the overall objective of this three-arm randomized controlled trial is to compare a dietary fiber-focused behavioral intervention to standard weight loss education for improving eating-related behavior and cognition, weight, and metabolic markers of chronic disease risk in a population of adults with obesity.


Eligibility criteria:
inclusion criteria: * 18-65 years of age * dietary fiber intake ≤25 grams/day * self-reported bmi ≥30 kg/m2 * willingness to attend in-person education sessions * willingness to avoid taking supplemental digestive aids (e.g., alpha-galactosidase (beano®), * willingness to provide informed consent. exclusion criteria: * metabolic, digestive, or allergic conditions or reactions that preclude consumption of whole food or food groups (e.g., irritable bowel syndrome, diverticulosis) * history of gastric bypass surgery * currently taking glucagon like glucagon-like peptide-1 (glp-1) receptor agonists * self-reported history of a diagnosed eating disorder * chronic disease (other than obesity) * pregnancy or lactation * use of tobacco or electronic smoking products * taking a pre-, pro-, or syn-biotic supplement * enrollment in another weight loss or diet intervention
progression of carotid artery atheroma in moderately hypercholesterolemic subjects

Conditions: Carotid Artery Stenosis; Hypercholesterolemia

Summary: the purpose of this study is to examine the changes in the carotid artery when subjects receive high or low doses of rosuvastatin.


Eligibility criteria:
inclusion criteria: * fasting blood low density lipoprotein cholesterol level as defined by the protocol * diagnosed carotid arterial stenosis exclusion criteria: * the use of lipid lowering drugs or dietary supplements after visit 1. * heavy or total occlusion of the carotid artery or recent stroke * uncontrolled hypertension, hypothyroidism, alcohol or drug abuse

Keywords: cholesterol carotid artery stenosis hypercholesterolemia rosuvastatin crestor
validation of the procedure of early liver transplantation in alcoholic hepatitis resisting to medical treatment

Conditions: Alcoholic Hepatitis; Alcoholic Cirrhosis

Summary: the purpose of this study is to validate a strategy of identification of patients for early liver transplantation in severe alcoholic hepatitis. in this setting, short-term survival is very low (approx. 25% at 6 months) and a pilot study has suggested (mathurin et al. n engl j med 2011) that liver transplantation may be an option in very carefully selected patients who did not respond to medical treatment. this selection process deserves to be confirmed in a population of greater size. we hypothesized that patients selected with this process would have a same alcohol relapse rate after liver transplantation than patients transplanted for alcoholic cirrhosis and selected using a 6-month sobriety period

non-inferiority of alcohol relapse in early liver transplantation for severe alcoholic hepatitis as compared to patients transplanted for alcoholic cirrhosis.

Eligibility criteria:
inclusion criteria (group a): * age \> 18 years * maddrey score \> 32 * liver biopsy confirming the diagnosis of alcoholic hepatitis * non-response to medical treatment: lille score ≥ 0.45 at day 7, or early worsening of liver function (meld score \> 25) despite a low lille score (\< 0.45) * hospitalization stay \< 1 month * algorithm score ≥ 220/250. inclusion criteria (group b): * age \>18 years * diagnosis of alcoholic cirrhosis * alcoholic withdrawal of 6 months minimum before inscription on the transplant list * meld score ≥ 15 for patients with hepatocellular carcinoma responding to milan criteria (1 node \< 5 cm or 3 nodes \< 3 cm) * meld score ≥ 20 preferably for patients not displaying hepatocellular carcinoma and that did not obtain an "expert" component * no recommendation of meld score for patients having obtained an "expert" component non-inclusion criteria (group a and b): * bacterial or viral infection uncontrolled by medical treatment * fungal or aspergillosis uncontrolled infection * hepatocellular carcinoma or invasive cancer * positive test for hbsag, positive test for hiv,positive pcr for hcv * portal thrombosis * pregnancy or breast-feeding woman

Keywords: alcoholic hepatitis liver transplantation alcohol relapse alcoholic cirrhosis
intervention to enhance prep uptake and adherence in a community-based setting

Conditions: Human Immunodeficiency Virus (HIV)

Summary: this study identifies social and behavioral factors likely to influence prep acceptability and adherence among men who have sex with men (msm), and collaborates with a community health center to evaluate a two-stage intervention to improve prep decision-making, as well as persistence and adherence for those who chose to take prep.

pre-exposure prophylaxis (prep) refers to daily or intermittent oral administration of antiretroviral drugs designed to protect high-risk hiv-negative individuals from infection. in order for prep to become an effective prevention tool, three critical factors must be addressed: a) acceptability, i.e., individuals who would benefit from prep must know about it and be willing to take it; b) adherence, i.e., individuals who choose to prep as a prevention strategy must take the pills as prescribed; and c) implementation, i.e., processes and protocols must be developed to allow for the integration of prep delivery and programs into real world settings in a way that is feasible, scalable, and realistic. this project has three specific aims: 1) identifying social and behavioral factors that are likely to influence prep implementation, acceptance, and use/adherence by men who have sex with men (msm) in nyc, including factors at individual-, community-, and organizational-levels; 2) examining social and behavioral factors associated with disparities in access to prevention and care services among msm in nyc that might directly impact prep implementation programs and policies; and 3) evaluating an intervention in which prep is introduced, provided, and supported as part of a prevention package delivered in an community health center. the project has the potential to exert a sustained and powerful influence not only on the effectiveness of prep interventions for msm, but also on dissemination and scalability of a targeted intervention within community-based settings and in a manner that reduces disparities in access and maximizes cultural competence and acceptability.

Eligibility criteria:
inclusion criteria: * registered patient receiving medical or health services at callen-lorde community health center * male sex (at birth) and reported sex with men or transwomen * at least 18 years of age * hiv-negative * at risk for hiv acquisition exclusion criteria: * past history of prep use or currently taking prep

Keywords: hiv pre-exposure prophylaxis prep msm demonstration project
antihypertensive effectiveness of the associations of hydrochlorothiazide and amiloride and hydrochlorothiazide and enalapril

Conditions: Hypertension

Summary: the majority of hypertensive patients require antihypertensive associations to control their blood pressure. most of clinical trials don't compare different associations using hydrochlorothiazide 25 mg as the standard initial therapy and compare the associations using doses that are not equivalent. this randomized trial where patients and investigators are blinded and compares the effectiveness two associations: hydrochlorothiazide and amiloride and hydrochlorothiazide and enalapril.


Eligibility criteria:
inclusion criteria: * patients who are using hydrochlorothiazide 25mg/d at least in a four weeks treatment and had their office blood pressure not controlled (systolic or diastolic greater than 140 mmhg or 90 mmhg, respectively). exclusion criteria: * established cardiovascular disease * diabetics in use of insulin * impairment renal in renal function * contraindications for the study medications
application of multimodal endoscopic functional imaging technology in the diagnosis of common gastrointestinal diseases

Conditions: Gastrointestinal Disease

Summary: we plan the study to explore the application of endoscopic laser speckle imaging and multispectral blood oxygen imaging to observe gastrointestinal lesions, as well as the differences in the morphology, density and functional status of mucosal surfaces and deep blood vessels of different gastrointestinal lesions, also to explore the role of endoscopic multimodal functional imaging in common gastrointestinal diseases, especially in the early diagnosis of gastrointestinal tumors.

the current focus of electronic endoscopy is on the morphology and fine structure of the mucosal surface, and there is no effective observation method for the deep structure of the mucosa and the function of blood oxygen binding. however, the multilayer morphology and functions of mucosal vessels under different conditions of digestive tract lesions should be different. therefore, we propose a method of endoscopic multimodal functional imaging to the conventional endoscopic examinations observing the mucosa of the digestive tract, which is based on the existing electronic endoscope, laser speckle contrast imaging and multispectral blood oxygen imaging technology. laser irradiation was given to obtain the information of coherent light on the mucosal surface and deep scattering of coherent light to obtain multi-level vascular distribution information, and multispectral irradiation imaging was carried out to obtain the oxygenation situation of the mucosa. finally, we may find the differences of images of deep blood vessels among common gastrointestinal diseases, which could help us to make early diagnosis of gastrointestinal tumors noninvasively.

Eligibility criteria:
inclusion criteria: 1. age: 18-80 years old, gender is not limited 2. diagnosed or suspected of one of the following common gastrointestinal mucosal diseases: chronic non-atrophic gastritis, chronic atrophic gastritis, gastric polyps, early gastric cancer, advanced gastric cancer, colon polyps, colon melanosis, inflammatory bowel disease, early colon cancer, advanced colon cancer 3. sign the informed consent form - exclusion criteria: 1. combined with cardiovascular and cerebrovascular diseases, or severe impairment of liver, kidney and hematopoietic system; 2. mentally ill; 3. the presence of bleeding disorders; 4. platelet count\<50×10\^9/l; 5. inability to tolerate or cooperate with endoscopy; 6. patients with serious complications, such as severe infection, gastrointestinal bleeding, obstruction, perforation, etc.; 7. pregnant or lactating women. 8. refuse to sign the informed consent form

Keywords: endoscopic laser speckle imaging multispectral blood oxygen imaging gastrointestinal lesions early diagnosis gastrointestinal tumors
effect of kmc on neurobehavior of preterm neonates

Conditions: Neonatal Neurobehavior

Summary: this prospective cohort study was conducted on stable preterm infants (31 to 35 weeks gestation). neonates were subjected to either daily kmc for 60 minutes, daily kmc for 120 minutes or conventional care (controls) for at least 7 days. neonates were evaluated by neonatal intensive care unit network neurobehavioral scale (nnns) at 36 weeks gestation. salivary cortisol was measured before and after first kmc session and after 7 days.


Eligibility criteria:
inclusion criteria: * stable preterm neonates with gestational age between 31 and 35 weeks. exclusion criteria: * neonates with major congenital birth defects or chromosomal anomalies. * perinatal asphyxia and intra-ventricular hemorrhage. * hemodynamically significant cardiac abnormalities. * neonates received postnatal steroids. * neonates whose mothers had a history of drug abuse during pregnancy.