Kornimate/medical-research-clean huggingface dataset:
hemofilter life span, ecls and/or crrt

Conditions: Kidney Diseases; Acute Injury of Kidney; Renal Failure; Renal Insufficiency; Neonatal Renal Disorder (Disorder)

Summary: the goal of this project to better understand the immune-modulatory effects of continuous renal replacement therapy (crrt) in neonatal and pediatric patients, particularly those receiving extracorporeal life support (ecls). little is known about the effects of crrt in this particular population and improved knowledge will be useful clinically and may lead to novel therapeutic approaches and improved outcomes for these critically ill patients.

via collection of serum and ultrafiltrate samples, the invesitgators will examine how hemofilter lifespan alters the filtration of pro- and anti-inflammatory cytokines.

Eligibility criteria:
inclusion criteria: * neonatal or pediatric patients receiving ecls (\>2 kilograms and \>34 weeks gestation) * crrt utilized during ecls course * for the secondary endpoints comparing crrt-mediated cytokine filtration in patients receiving ecls with concurrent crrt to patients receiving crrt alone (no ecls), the investigators will also enroll neonatal and pediatric patients receiving crrt alone (no ecls). patients will be eligible for entry into this study if they meet all of the following criteria: * neonatal or pediatric patients receiving crrt exclusion criteria: -those patients with inability or unwillingness of legal guardian/representative to give informed consent

Keywords: extracorporeal life support extracorporeal membrane oxygenation acute kidney injury renal replacement therapy renal support therapy kidney support therapy
the impact of the practice of touch-massage on the anxiety of patients with hematological disorders hospitalized in a protective environment, a randomized, controlled study

Conditions: Hematologic Diseases

Summary: each year, 17000 cases of severe hematological diseases are diagnosed in france, with more than 6,000 of these requiring hospitalization in a protective, sterile environment. new methods, such as touch massage, have emerged in response to anxiety symptoms observed in patients in such sterile and isolated surroundings. we hypothesize that during the period of isolation, touch massage becomes a nursing care which can help the patient.

patients with hematologic diseases (leukaemia, myeloma, lymphoma) hospitalized in a sterile area of a hematology unit for at least 3 weeks 18 to 65 years female or male not having met the nurse, who is providing the touch-massage

Eligibility criteria:
inclusion criteria: * patients with hematologic diseases (leukaemia, myeloma, lymphoma) hospitalized in a sterile area of a hematology unit for at least 3 weeks * 18 to 65 years * female or male * not having met the nurse, who is providing the touch-massage exclusion criteria: * allergy to sweet almond oil * injury to the skin, at the back and / or arms and / or hands * cognitive impairment and / or preventing psychiatric responses to interviews and / or questionnaires * physical inability to take sitting in an ergonomic chair for the conduct of touch massage.

Keywords: touch-massage anxiety leukemia haematology cancerology supportive care complementary therapy
determination of safety and consumers' satisfaction of moussik versus desitin creamy ointment in diaper rash prophylaxis

Conditions: Diaper Rash

Summary: the purpose of this clinical observation is to evaluate the safety and consumers' satisfaction of moussik vs desitin creamy ointment as a diaper rash protection product.


Eligibility criteria:
inclusion criteria: * healthy male or female infants aged between 3-18 months who are routine users of disposable diapers exclusion criteria: * children with symptoms of systemic disease or skin lesions. * children diagnosed as having diaper dermatitis at baseline * known hypersensitivity to any of the components of the trial preparations. * children suffering from atopic diseases. * children who have participated during the last month in another clinical trial.

Keywords: diaper dermatitis diaper rash erythema
efficacy study of an olfactory stimulation program for the recuperation of autobiographical memories in anorexia

Conditions: Anorexic

Summary: the purpose of this study is to estimate the impact of an olfactive stimulation, in relaxing environment, on the access at the autobiographical memories in anorexic patients.


Eligibility criteria:
inclusion criteria: * eating disorders, anorexia (restrictive form or mixed) according to dsm iv-tr ( diagnostic and statistical manual of mental disorders iv - text revision) criteria * patient hospitalized in a department of one of the inquiring centers for a minimal duration of 5 weeks * french language ability * coverage by the social insurance * fully informed patient who consent to participate in the study exclusion criteria: * major mental associated disorders (psychotic disorders, bipolar disorder, major depression), neurological disorders or addiction to substances * psychotropic treatment (with the exception of antidepressants, anxiolytics and sleeping drugs, if the treatment was started more than 30 days ago) * any disorder susceptible to alter the reasoning capacities, discernment or judgment * physically or psychologically unable to answer questionnaires

Keywords: anorexic olfactory stimulation autobiographical memories recovery
a study of bevacizumab in combination with gemcitabine and carboplatin in participants with triple negative metastatic breast cancer

Conditions: Breast Cancer

Summary: this multicenter study will assess the efficacy and safety of bevacizumab in combination with gemcitabine and cisplatin as first line treatment in participants with triple negative metastatic breast cancer. participants will receive bevacizumab at a dose of 15 mg/kg intravenously (iv) every 3 weeks, plus gemcitabine (1000 mg/m2 iv) and carboplatin (iv to an area under curve \[auc\]=2) on days 1 and 8 of each 3-week cycle. anticipated time on study treatment is until disease progression.


Eligibility criteria:
inclusion criteria: * female participants, \>/= 18 years of age * metastatic breast cancer * estrogen receptor-, progesterone- and human epidermal growth factor receptor 2 (her2)-negative disease * treatment-naïve for metastatic breast cancer * eastern cooperative oncology group (ecog) performance status 0-2 * adequate hematological, renal and liver function * patients should have received anthracyclines and taxanes in the adjuvant setting * women of childbearing potential must agree to use adequate contraception (per institutional standard of care) during treatment and until 6 months after the last administration of investigational products exclusion criteria: * prior first line treatment for metastatic breast cancer * central nervous system (cns) metastasis * uncontrolled hypertension (\> 170/95 mmhg) * evidence of bleeding diathesis, coagulopathy or hemorrhage at baseline * other malignancy within the last 5 years, except for adequately treated carcinoma in situ of the cervix or squamous carcinoma of the skin, or adequately controlled limited basal cell skin cancer. * prior therapy with gemcitabine or carboplatin in the metastatic setting. participants having received gemcitabine or carboplatin as part of adjuvant therapy are eligible, if recurrence was first documented \>6 months after the last exposure to the drug(s) * requirement of chronic use of immunosuppressive agents * hiv, hepatitis b or hepatitis c infection
women overcoming and managing adversity now (woman) study

Conditions: Posttraumatic Stress Disorder; PTSD

Summary: the goal of the study is to evaluate the efficacy of a two therapeutic models designed to enhance women's skills for managing reactive emotions in their current lives as well as to educate them about how using these skills can enhance their personal effectiveness and help them to gain control of post-traumatic stress reactions. the interventions adaptations of a manualized psychotherapy that has shown promise with adults with complex posttraumatic stress disorder (ptsd) (trauma affect regulation: guide for education and therapy; target) compared to a supportive group therapy (sgt) that has been found to have modest benefits with women survivors of childhood abuse (wallis, 2002).

in a randomized treatment design, we will compare offenders receiving skills-based intervention (target) and those receiving a similar amount of supportive intervention (sgt). we will assess the efficacy of treatment by determining if those receiving the target skills training show an improvement in functionality, as compared to those receiving only supportive intervention. we will measure this by analyzing ptsd symptoms, psychological distress, psychosocial functioning, and social/legal adjustment and services using structured interviews, self-report questionnaires and qualitative questions. questionnaires are listed below in the outcome measure's section. we will collect follow-up data on program participants who successfully finish the program at york. for those offenders who discharge into the community directly from york, we will collect follow-up data on program participants through cdoc parole or probation records. statistically we anticipate a medium effect size difference between the treatment conditions.

Eligibility criteria:
inclusion criteria: * incarcerated, release not expected within 6 months * probable ptsd on pc-ptsd screen and ptsd by caps interview exclusion criteria * clinically significant psychopathy (pcl-sv severe range) * unable to comprehend study materials (mini-mental status exam orientation, attention, and recall sections total score \<15).

Keywords: women ptsd group therapy incarceration
the follow-up study for the patients of illicit substance use disorder

Conditions: Substance Use Disorders; Illicit Drug Use

Summary: the patients will be diagnosed according to dsm-5, the severity of individual substance use disorder will be assessed, and the plan of treatment will be provided. the treatment will be determined by the diagnosis and severity of addiction, the mood or psychiatric comorbidities, the hyperactivity or attention deficit, alcohol addiction, and etc. the motivational enhancement interview, the individual psychotherapy, the group psychotherapy, the family therapy will be provided by our team members. in order to evaluate the efficacy of the different therapy, we will evaluate the psychological and social status of the patients and follow up every 3 months. the efficacy of different treatment will be evaluated according to our study instruments.

the patients will be diagnosed according to dsm-5, the severity of individual addiction will be assessed, and the plan of treatment will be provided. the treatment will be determined by the diagnosis and severity of addiction, the mood or psychiatric comorbidities, the hyperactivity or attention deficit, alcohol addiction, and etc. the motivational enhancement interview, the individual psychotherapy, the group psychotherapy, the family therapy will be provided by our team members. in order to evaluate the efficacy of the different therapy, we will evaluate the psychological and social status of the patients and follow up every 3 months. the patients will be received the basic physiological assessment, the chest x-ray, electrocardiogram, liver and renal function, hematology test, urine screening for addictive substances, screening for blood infectious diseases (including hepatitis b, c and hiv infection) will be included. besides, the drug abuse screen test (dast), the severity of dependence scale (sds), the reliability of readiness to change questionnaire, the opiate treatment index (oti), drug avoidance self-efficacy scale (dases), the family apgar score, the brief version of the world health organization quality of life instrument (whoqol-bref taiwan version), chinese health questionnaire (chq), parental bonding instrument (pbi), toronto alexithymia scale (tas), brief symptom rating scale (bsrs-5), chinese version of adult adhd self-report scale (asrs-v1. 1), becker depression scale (bdi) and becker anxiety scale (bai) will be evaluated every 3 months after receiving our treatment.

Eligibility criteria:
inclusion criteria: patients with illicit substance use disorder diagnosed by dsm-5 exclusion criteria: the age of the patient is below 20 years old or above 65 years old, the patients cannot cooperate with the tools of investigation
the effects of videogames on depression symptoms and brain dynamics

Conditions: Major Depressive Disorder

Summary: the purpose of the study is to evaluate the effects of a game-based digital-therapeutics (dtx) medical software device on the symptoms of depression in adults with confirmed major depressive disorder.

the study is a comparator-controlled, randomised, double-blinded intervention study aimed at assessing the effects of the investigational device mel-t01, "meliora", on the symptoms of major depressive disorder (mdd). mel-s01 acts as a comparator. mel-t01 is a game-based digital-therapeutics (dtx) medical software device developed at aalto university and is intended to be used as a treatment for mdd together with treatment-as-usual (tau). mel-t01 implements personalised cognitive training to alleviate mdd symptoms and improve cognitive performance in mdd subjects. subjects volunteering to participate in this investigation are adults whose mdd is confirmed through mini interview. they have an on-going mental health treatment contact with a mental health professional. the subjects are randomised into three arms with equal probabilities in blocks of six consecutive subjects. subjects in the mel-t01 and mel-s01 arms are engaged in the intervention for 12 weeks while those in the tau arm are on a follow-up period during these 12 weeks. after this 12-week period, the subjects in mel-t01 and mel-s01 arms enter a 12-week follow-up period and the subjects in tau arm engage with either the mel-t01 or mel-s01 intervention (randomised at t0 with equal probability) for 12 weeks. the subjects are recommended to play the investigational-device game for a total of 48 hours during the 12 weeks of active intervention with a recommended weekly dose of 4 hours. a minimum of 24 hours is needed for inclusion to hypothesis testing. the subjects are limited to a daily maximum of 1.5 hours of game time. the subjects' mental health symptoms and well-being are evaluated through online questionnaires five times: before subjects are randomised into one of the three groups (t0), and then 4 (t1), 8 (t2), 12 (t3), and 24 (t4) weeks after the study has begun.

Eligibility criteria:
inclusion criteria: * between 18-65 year-old * suffering from major depressive disorder * have an ongoing mental health treatment contact to basic healthcare, specialised healthcare, student healthcare or occupational healthcare * has sufficient eyesight with or without prescription * has a windows computer with internet connection and mouse * has email and phone number exclusion criteria: * they have threat of self-harm * they have addiction to digital games * they have psychotic disorders * they are pregnant or breastfeeding * they have impaired ability in decision making * they are prisoner or forensic subject * they have neurological disorders such as epilepsy or brain injury

Keywords: depression digital therapeutics digital mental health intervention
prevalence of circulating parvovirus genome in recently diagnosed graves' disease: a case-control study

Conditions: Graves Disease

Summary: lymphocytic thyroiditis is the most common autoimmune disease, usually affecting young women. although the aetiology and pathogenesis remain obscure, the most widely accepted hypothesis is an interaction between a genetic predisposition and an environmental trigger factor such as viral infection. parvovirus infections have been proposed as trigger factors for hashimoto's thyroiditis and graves' disease.


Eligibility criteria:
inclusion criteria: * graves' disease :patients treated for graves' disease, the diagnosis date less than 4 months * control : patients cared for nodules or goiter exclusion criteria: * patients undergoing immunosuppressive therapy including corticosteroids

Keywords: parvovirus genome
the effect of virtual reality glasses on the behavior of children with autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: the aim of this study is to determine whether the use of virtual reality glasses showing an immersive video simulation of the dental visit will help decrease anxiety at future appointments by decreasing the element of surprise and increasing the patient's familiarity and comfort level with a specific dental practice environment.

after an initial baseline data collection visit to the dental clinic, patients will be placed in the virtual reality (vr) group or the no vr group. caregivers in the vr group will be given vr glasses. they will be instructed how to access the video and use the glasses. the child/wearer of the glasses will feel immersed in the three-dimensional environment and be able to look around the room as they move down the hallways in the video. the caregiver will be encouraged to have the child wear the vr glasses as often as possible and record the number of times the video is watched. the caregiver will fill out a "records form" which will include the date and time the video was watched. both groups will then return to the clinic for follow up data collection visit.

Eligibility criteria:
inclusion criteria: * autism spectrum disorder (asd) exclusion criteria: * no specific diagnosis of autism spectrum disorder (asd) * limited english proficiency * existing patient of vcu department of pediatric dentistry * parent/guardian determination that child would not be avle to tolerate immersive simulation with vr glasses
the role of endothelium a and egfr receptor in fibrocytes from asthma with obstructive sleep apnea

Conditions: Asthma; OSA

Summary: the investigators will compare the circulating fibrocyte proportion in asthmatic patients with obstructive sleep apnea (osa) and not with osa in addition, the investigators will compare the expression of epidermal growth factor receptor (egfr), endothelin a receptor (etar) and connective tissue growth factor (ctgf) the association of those factors and annual decline of forced expiratory volume in 1 second (fev1) will be performed

asthma is characterized by airflow obstruction, chronic airway inflammation and remodeling. the investigators' report has shown directly the relationship between fibrocytes, and chronic airflow obstruction with rapid decline in fev1 in asthma. asthma concomitant of obstructive sleep apnea (osa) may appear intermittent hypoxia and result in the frequent attack of asthma symptoms. in animal model, hypoxia may increase the circulating fibrocytes, thus play a role in pulmonary hypertension. the investigators' published paper also showed that an increased expression of egfr, etar and vascular endothelial growth factor receptor (vegfr) in circulating fibrocytes in chronic obstructive asthmatics. it is unknown whether circulating fibrocytes from asthma with osa have the higher expression of egfr, connective tissue growth factor receptor, vegfr and etar compared to asthma without osa. the investigators are also interested in whether proliferation and differentiation of fibrocytes are different between asthmatics with or without concomitant of osa. the investigators will study the correlation between the percentage of circulating fibrocytes and the oxygen desaturation index (odi) and severity of sleep apnea to clarify the role of hypoxia, which contributing to chronic asthma.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of asthma exclusion criteria: * chronic obstructive pulmonary disease (copd) * bronchiectasis * cystic fibrosis

Keywords: asthma fibrocyte airway remodeling osa hypoxia
treatment with elexacaftor/tezacaftor/ivacaftor, in patients with cystic fibrosis and caloric intake

Conditions: Cystic Fibrosis

Summary: the aim of the study is to describe the evolution of caloric intake in patients with cystic fibrosis with an indication to start treatment with elexacaftor/tezacaftor/ivacaftor according to the marketing authorization, between the start of treatment and at 12 months.

cystic fibrosis is a genetic pathology linked to a dysfunction of the cftr protein. undernutrition is common in the natural course of cystic fibrosis, it is linked to exocrine pancreatic insufficiency but also to the increase in energy expenditure due to respiratory damage. at a time when these cftr modulators are greatly modifying the prognosis and management of cystic fibrosis, it is important to describe how caloric and nutritional intake evolve under treatment with elexacaftor/tezacaftor/ivacaftor in order to be able, in the long term, to adapt nutritional recommendations under treatment with cftr modulators. the aim of the study is to describe the evolution of caloric intake in patients with cystic fibrosis with an indication to start treatment with elexacaftor/tezacaftor/ivacaftor according to the marketing authorization, between the start of treatment and at 12 months.

Eligibility criteria:
inclusion criteria: * patient with cystic fibrosis * patient with an indication to start treatment with elexacaftor/tezacaftor/ivacaftor according to the marketing authorization. * patient who has not received treatment with cftr modulators in the 6 months preceding inclusion. * no opposition expressed by the patient (if ≥ 18 years) or by at least one of the holders of parental authority and the child (if \< 18 years). * be affiliated to a social security scheme or be a beneficiary of such a scheme. exclusion criteria: -

Keywords: caloric intake
insulin-based strategies to prevent hypoglycemia during exercise

Conditions: Type 1 Diabetes

Summary: it has been reported that insulin basal rate reduction initiated at exercise onset can reduce the hypoglycemic risk during exercise. however, another potentially more efficient strategy to prevent exercise-induced hypoglycemia could be to reduce insulin basal rate a certain time prior to exercise. no study investigated what would be the best timing to initiate such temporary basal insulin reduction. therefore, the objective of this study will be to compare the efficacy of three strategies to prevent exercise-induced hypoglycemia during a 45 min exercise at 60% vo2peak (moderate intensity): 1) reduce insulin basal rate at the time of exercise; 2) reduce insulin basal rate 20 minutes prior to exercise; 3) reduce insulin basal rate 40 minutes prior to exercise. investigators hypothesize that the time spent in hypoglycemia will be less when the insulin basal rate is reduced 40 minutes prior to exercise compared to a reduction at the time of exercise. secondary hypotheses are: 1) time spent in hypoglycemia will be less when the insulin basal rate is reduced 20 minutes prior to exercise compared to a reduction at the time of exercise; 2) time spent in hypoglycemia will be less when the insulin basal rate is reduced 40 minutes prior to exercise compared to a reduction 20 minutes prior to exercise.


Eligibility criteria:
inclusion criteria: 1. males and females ≥ 18 years of old. 2. clinical diagnosis of type 1 diabetes for at least one year. 3. the subject will have been on insulin pump therapy for at least 3 months. 4. last (less than 2 months) hba1c ≤ 12%. exclusion criteria: 1. clinically significant microvascular complications: nephropathy (estimated glomerular filtration rate below 40 ml/min), neuropathy (especially diagnosed gastroparesis) or severe proliferative retinopathy as judged by the investigator. 2. recent (\< 3 months) acute macrovascular event e.g. acute coronary syndrome or cardiac surgery. 3. abnormal blood panel and/or anemia. 4. ongoing pregnancy. 5. severe hypoglycemic episode within two weeks of screening. 6. other serious medical illness likely to interfere with study participation or with the ability to complete the exercise periods by the judgment of the investigator (e.g. orthopedic limitation). 7. failure to comply with team's recommendations (e.g. not willing to change pump parameters, etc.).

Keywords: type 1 diabetes exercise hypoglycemia insulin pump