Kornimate/medical-research-clean huggingface dataset:
noradrenaline versus glypressin for prevention of hypotension after deflation of tourniquet in knee arthroplasty

Conditions: Norepinephrine, Glypressin, Tourniquet Deflation; Hypotension

Summary: pneumatic tourniquet is usually used in orthopedic surgeries, as it helps to decrease operative bed bleeding, and thus, maintaining a clean and dry surgical field allowing easy and clear identification of the anatomical structures. despite that advantage, after its deflation, there is a blood volume shift towards that ischemic area, which may decrease cardiac preload leading to hypotension

hemodynamic changes after tourniquet deflation include; hypotension, tachycardia and increase in cardiac index. these changes may be insignificant for healthy individuals but, risky for patients with compromised cardiovascular system and geriatric population. hypovolemia is a common problem in many clinical situations. the mortality of hypovolemic shock is directly related to the severity and duration of organ hypoperfusion. management of hypotension include frequent monitoring of blood pressure, fluid therapy, non-pharmacological methods, and vasopressors. fluid therapy by crystalloids or colloids has been the traditional approach to restore volume and can be given as preload or co-load .non pharmacological methods include positioning and leg compression. trendelenburg position can increase venous return to the heart. leg compression by flexion of the hip, elastic bandages, or stockings. an efficient method to treat spinal hypotension is administration of vasopressors, either given by infusion or boluses. vasopressor drugs act by reversing the circulatory effect of sympathetic blockade. they also restore vascular tone and preserve venous return and cardiac filling

Eligibility criteria:
inclusion criteria: * adult patients of both gender * american society of anesthesiologists (asa) i or ii * scheduled for elective unilateral total knee arthroplasty exclusion criteria * patient refusal. * major cardiopulmonary disorders * uncontrolled systemic hypertension. * hepatic or renal disorders. * patient with relative contraindication for tourniquet use as peripheral vascular disease, sickle cell anemia, deep venous thrombosis, diabetic neuropathy and crushed injury. * cases having american society of anesthesiologists \[asa\] \> ii * coagulopathy and bleeding tendency. * revision knee arthroplasty and bilateral knee arthroplasty
body composition monitor in hemodialysis patients

Conditions: End Stage Renal Disease

Summary: control of volume status is a pivotal issue in haemodialysis therapy. objective and practical management for maintaining normovolemia is needed. the investigators hypothesized that intervention of volume status with the body composition monitor (bcm) may improved hemodynamic parameters and biomarkers in hemodialysis patients.

the investigators will assess bcm in enrolled hemodialysis patients by 4 weeks for 16 weeks during the former 8-week intervention period, the investigators will adjust patients' volume status according to the results of bcm. during the latter 8-week observational period, the investigators will evaluate the changes of patients' hemodynamic parameters and biomarkers.

Eligibility criteria:
inclusion criteria: * 6-month or more stable hemodialysis patients * 18 years or more * less than 5% of changes of dry weight for last 3 months exclusion criteria: * pregnancy * active malignancy * cardiac pacemaker or defibrillator * history of extremity amputation * active infectious disease within 3 months * admission history for complication related to hemodialysis within 3 months

Keywords: body composition blood pressure hemodialysis
glaucoma treatment by circular cyclocoagulation using high intensity focused ultrasound with the eyeop medical device

Conditions: Glaucoma

Summary: the aim of the study is to evaluate the effectiveness and the safety of the eyeop treatment using high intensity focused ultrasound in refractory glaucoma patients.


Eligibility criteria:
inclusion criteria: * primary open angle glaucoma included pseudo-exfoliative glaucoma and pigmentary glaucoma in the study eye with maximally tolerated medical treatment * ocular hypertension defined as an intraocular pressure (iop) \> 21 mm hg * subject has failed a conventional intraocular glaucoma filtering surgery * patient must be aged 18 years or more * no previous intraocular glaucoma surgery or laser treatment in the study eye during the 3 months before hifu treatment * no previous cyclophotocoagulation procedure in the study eye * patient able and willing to provide informed consent and to complete post-operative follow-up requirements. exclusion criteria: * history of previous glaucoma surgery with implantation of glaucoma drainage device in the study eye * history of ocular or retrobulbar tumor * retinal detachment, choroidal hemorrhage or detachment * ocular infectious disease within 14 days before hifu treatment

Keywords: glaucoma refractory glaucoma cyclocoagulation high intensity focused ultrasound
physical activity intervention on myocardial function in patients with her2 + breast cancer

Conditions: Breast Cancer

Summary: purpose of the study is to examine the effects of 3 months of physical activity intervention on myocardial function (left ventricular ejection fraction) in patients with her2+ breast cancer

primary objective: to evaluate in patients with her2 + breast cancer, treated only by trastuzumab, the impact of three months individualized physical activity intervention (55 minutes, 3 times per week) on left ventricular ejection fraction (lvef). secondary objectives: to evaluate the impact of physical activity intervention on body composition, muscle function, metabolic, hormonal and inflammatory responses, pain, fatigue and quality of life. this study examines patients aged 18 to 85 years, diagnosed with early breast cancer with her2 overexpression confirmed histologically and eligible to receive treatment with trastuzumab (adjuvant). this study includes 3 assessments phases: baseline (t0), 3 months (t3) and 6 months (t6) for both arms. the programme is organised as follows: arm a "standard oncologic care coupled with physical activity intervention (3 times / week) " for 3 months ; arm b (control group) "standard oncologic care". between t3 and t6, volontary physical activity level will follow by actimetry.

Eligibility criteria:
inclusion criteria: * patients aged 18 to 85 years * first breast cancer her2 + histologically confirmed, * who grade performance index ≤1 * normal renal function (creatinine clearance ≥ 60 ml min-1) * normal heart function with lvef ≥ 50% * normal liver function (ast and alt normal) * physical activity certificate issued by a cardiologist or an oncologist, * active contraception or postmenopausal exclusion criteria: * patients aged under 18 and over 85 * patients having no breast cancer her2+ * patients with metastases * heart failure (lvef ≤50%) and respiratory (o2 saturation ≤ 92%), * autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis) * symptomatic osteoarthritis, * cardiovascular diseases (angina or uncontrolled high blood pressure) or heart-lung (chronic obstructive pulmonary disease) * patients suffering from malnutrition (body mass index (bmi) \<18 kg m-2) or weight loss of over 10% during the last 3 months, * patients with psychiatric or cognitive disorders deemed unsuitable for a sporting activity * pregnant or lactating patients.
comparative effects of acbt and slow expiration in patients with chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: chronic obstructive pulmonary disease (copd) is characterized by nonreversible airway obstruction. a diagnosis of copd is determined by clinical assessment of airflow limitation and symptoms such as cough and wheeze; however, the detrimental effect of copd symptoms on a patient's quality of life is often underestimated. rehabilitation exercise can lessen the possibility of the progressive exacerbation of the patient's condition, exerting an active role in improving their lung function and the quality of the patients' life .therefore, active cycle breathing techniques (acbt) is a cycle of techniques consisting of breathing control, lower thoracic expansion exercises and the forced expiration technique modifiable for every patient to reduce condition . the effect of eltgol on mucus clearance of right and left lungs, especially of peripheral lung areas, in stable patients with copd . a couple of relaxed breaths and when you are ready go on to your huff. repeat the huff two or three times until you have the urge to cough. once you have cleared your chest have a few normal relaxed breaths and start the cycle over again with deep breaths and huffs. a randomized clinical trial, subjects with age group between 4o-70 years. in group -a subjects (n=15) were treated with active cycle of breathing technique where group-b subjects (n=15) received eltgol training . this study is to compare the effectiveness of acbt and eltgol on improving the quality of life and increasing functional capacity in subjects with copd . assessment will be done before and after intervention and result will be analyzed using statistical package for social sciences spss 20.


Eligibility criteria:
inclusion criteria: * both genders (male and female) * 40-70 years * diagnosed copd according to gold classification * hemodynamically stable patient exclusion criteria: * patient with other disorders like cardiac and respiratory disorders * carcinoma * lung surgery * neurological disorders

Keywords: copd(chronic obstructive pulmonary disease), acbt(active cycle of breathing techniques) eltgol
a study of brentuximab vedotin combined with nivolumab for relapsed or refractory hodgkin lymphoma

Conditions: Hodgkin Lymphoma

Summary: the purpose of this study is to assess the safety profile and antitumor activity of brentuximab vedotin administered in combination with nivolumab in patients with relapsed or refractory hodgkin lymphoma (hl)

this study will examine the safety profile and antitumor activity when brentuximab vedotin is combined with nivolumab. patients will be treated for up to four 21-day cycles with brentuximab vedotin 1.8 mg/kg and nivolumab 3 mg/kg. there will be 3 parts to this study. in part 1, the safety of combination treatment will be evaluated by a safety monitoring committee (smc) prior to expansion of enrollment to evaluate treatment effect in part 2. part 2 of the study will further characterize the safety and antitumor activity of brentuximab vedotin combined with nivolumab by enrolling patients at the recommended dose schedule determined in part 1. part 3 of the study will evaluate the safety and antitumor activity of combination treatment administered at an alternate dosing schedule determined by cumulative safety and activity data from parts 1 and 2.

Eligibility criteria:
inclusion criteria: * relapsed or refractory hodgkin lymphoma following failure of standard frontline chemotherapy for the treatment of classical hodgkin lymphoma * eastern cooperative oncology group (ecog) performance status of 0 or 1 exclusion criteria: * previously treated with brentuximab vedotin, immune-oncology agents, or received an allogeneic or autologous stem cell transplant * documented history of a cerebral vascular event * history of another invasive malignancy that has not been in remission for at least 3 years * history of progressive multifocal leukoencephalopathy (pml)

Keywords: monomethyl auristatin e antigens, cd30 antibody-drug conjugate antibodies, monoclonal immunotherapy autologous stem cell transplant
graft-augmented rectocele repair-a randomized surgical trial

Conditions: Rectocele

Summary: the purpose of this study is to determine whether adding a graft during a rectocele repair will improve the success rate of the repair.

rectoceles may have a significant effect on the quality of life of women. symptoms associated with rectoceles include a protruding vaginal mass, persistent pelvic pressure, and sexual dysfunction. surgical repair is the most common treatment with success rates ranging from 65%-85% at 1-2 years. in an attempt to improve surgical outcomes, clinicians are using graft materials to augment weakened tissues in rectocele repairs: however, there is little data to support or refute these practices. the purpose of this study is to estimate the effect of graft augmentation on objective and subjective outcomes. comparison: rectocele repair without graft, compared to rectocele repair with the surgisis (tm) graft.

Eligibility criteria:
inclusion criteria: * women with stage 2 or greater symptomatic rectocele * women electing to undergo surgical rectocele repair * women over age 21 years * women willing to comply with study procedures and follow-up exclusion criteria: * pregnant or nursing women * history of porcine allergy * history of connective tissue disease, pelvic malignancy, or pelvic radiation * women undergoing concurrent sacral colpopexy

Keywords: rectocele pelvic prolapse graft surgical repair
sacral neuromodulation & urodynamics

Conditions: Overactive Bladder; Non-obstructive Urinary Retention

Summary: in the field of urology, sacral neuromodulation (snm) is a well-accepted, second-line, minimally invasive treatment for patients with overactive bladder dry (oabd) or wet (oabw), and for patients with non-obstructive urinary retention (nour). long-term vary between 50-60%. this study examines whether urodynamics can be used as a predictor for successful snm therapy


Eligibility criteria:
inclusion criteria: * overactive bladder * non-obstructive urinary retention exclusion criteria: * neurogenica disorder (e.g. cerebrovascular accident, spinal cord injury)
18f-fmau pet/ct and mri for the detection of brain tumors in patients with brain cancer or brain metastases

Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Clinical Stage IV Cutaneous Melanoma AJCC v8; Glioma; Malignant Brain Neoplasm; Metastatic Breast Carcinoma; Metastatic Colon Carcinoma; Metastatic Kidney Carcinoma; Metastatic Lung Carcinoma; Metastatic Malignant Neoplasm in the Brain; Metastatic Melanoma; Pathologic Stage IV Cutaneous Melanoma AJCC v8; Prognostic Stage IV Breast Cancer AJCC v8; Stage IV Colon Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IV Renal Cell Cancer AJCC v8; Stage IVA Colon Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Colon Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8; Stage IVC Colon Cancer AJCC v8

Summary: this early phase i trial tests the use of a radioactive tracer (a drug that is visible during an imaging test) known as 18f-fmau, for imaging with positron emission tomography/computed tomography (pet/ct) in patients with brain cancer or cancer that has spread to the brain (brain metastases). a pet/ct scan is an imaging test that uses a small amount of radioactive tracer (given through the vein) to take detailed pictures of areas inside the body where the tracer is taken up. 18f-fmau may also help find the cancer and how far the disease has spread. magnetic resonance imaging (mri) is a type of imaging test used to diagnose brain tumors. 18f-fmau pet/ct in addition to mri may make the finding and diagnosing of brain tumor easier.

primary objectives: i. assess the correlation between multiparametric magnetic resonance imaging (mpmri) radiomics and dynamic 2'-fluoro-5-methyl-1-beta-d-arabinofuranosyluracil (fmau) pet kinetic analysis parameters. ii. explore the different pattern in radiomics mpmri and fmau pet kinetic analysis parameters between patients with presence or absence of recurrent tumor. outline: patients receive 18f-fmau intravenously (iv) and undergo a pet/ct scan over 60 minutes. patients then undergo standard of care mpmri over approximately 45 minutes. after completion of study intervention, patients are followed up at 24-96 hours after their 18f-fmau pet/ct scan.

Eligibility criteria:
inclusion criteria: * age \> 18 years, both men and women * documented history of either primary brain tumor (e.g. glioma) or metastatic brain tumor from another primary cancer (e.g. lung, breast, colon, melanoma, kidney) * documented radiation therapy regardless of treatments prior to radiation therapy exclusion criteria: * unable to give consent * inability to remain motionless during imaging studies * intractable seizures * claustrophobia * implantable devices incompatible with magnetic resonance (mr) environment
parental knowledge and beliefs about infant sleep position

Conditions: Sudden Infant Death Syndrome

Summary: in the united states, sudden infant death syndrome (sids)is the leading cause of death in infants between the ages of 1 and 12 months. the etiology of sids is still not clear although a number of risk factors have been identified. sleeping on the stomach has been identified as a major risk for sids. the rates of sids have dropped substantially in countries in which the usual sleep position has changed from the stomach to the side or back. back sleep has been shown to be the most stable and safest position. the american academy of pediatrics now recommends the back sleeping position for all healthy infants. since the american academy of pediatrics began advocating the back sleep position, the incidence of sids has decreased by more than 40% in this country. however, the decrease has not been uniform across segments of the population. black infants continue to have a higher rate of sids compared with other groups. this discrepancy could be related to infant sleep position practices. several studies have shown that infants born to low income, minority, inner-city families were more likely to be placed on the stomach to sleep. education appears to influence choice of sleep position and may explain, at least to some degree, the difference in choice of sleep position among certain groups. we believe that uniform education of parents will influence the sleep position that parents choose for their baby. we will undertake this initial study to document what parents choose to do with their infants regarding sleep position and why they make these choices so that we can improve our educational approach.


Eligibility criteria:
inclusion criteria: * parent of a two-week old infant born in the well newborn nursery at yale-new haven hospital. infant is brought for well child care at yale-new haven hospital primary care center
acquisition and analysis of relationships between longitudinal emotional signals produced by an artificial intelligence algorithm and self-questionnaires used in the psychiatric follow-up of patients with mood and/or anxiety disorders: a real-environment study.

Conditions: Anxiety Disorders; Major Depressive Disorder

Summary: the worldwide prevalence of anxiety and depression increased massively during the pandemic, with a 25% rise in the number of patients suffering from psychological distress. psychiatrists, and even more so general practitioners, need measurement tools that enable them to remotely monitor their patients' psychological state of health, and to be automatically alerted in the event of a break in behavior. in this study, the investigators propose to collect clinical data along with longitudinal measurement of patients' emotions. emobot proposes to analyze the evolution of mood disorders over time by passively studying people's emotional behavior. the aim of emoacq-1 is to acquire knowledge and produce a quantitative link between emotional expression and mood disorders, ultimately facilitating the understanding and management of these disorders. through this study, could be developed a technological solution to support healthcare professionals and patients in psychiatry, a field known as the "poor relation of medicine" and lacking in resources. such a solution would enable better understanding, disorders remote \& continuous monitoring and, ultimately, better treatment of these disorders. the investigators will process the data by carrying out a number of analyses, including descriptive, comparative and correlation studies of the data from the self-questionnaire results and the emotional signals captured by the devices. finally, the aim will be to predict questionnaire scores from the emotional signals produced.


Eligibility criteria:
inclusion criteria: * persons over the age of 18 who volunteer to take part in research * must have access to a computer with an internet connection, * written comprehension of french. exclusion criteria: * n/a
robot-assisted therapy combined with mirror priming in upper limb training in stroke

Conditions: Stroke

Summary: this project will employ the robot-assisted system to assist patients to perform the grasping and releasing movement of both hands simultaneously while mirror priming strategy is applied, and, then, perform intensive and game-based finger movement training with the robotic assistance. this randomized controlled trial is the first study to explore the benefits of combined robotic-assisted therapy and mirror priming strategy in stroke patients. this proposed combined approach might be a novel combination of enhancing movement performance, daily function and quality of life for patients with stroke.

approximately 70% to 80 % of stroke patients suffered from upper limb (ue) hemiparesis which limited their daily function and quality of life, as well as required considerable demands of long-term medical care. robot-assisted training and mirror priming has been advocated as part of contemporary approaches. the robotic-assisted therapy mainly emphasized on the proximal part of ue, such as shoulder and elbow movement. while mirror priming strategy has been increasingly employed in the ue training, one question has been raised: the affected ue of stroke patients cannot complete the same movement as the sounded limb synchronously. this project will employ the robot-assisted system to assist patients to perform the grasping and releasing movement of both hands simultaneously while mirror priming strategy is applied, and, then, perform intensive and game-based finger movement training with the robotic assistance. this randomized controlled trial is the first study to explore the benefits of combined robotic-assisted therapy and mirror priming strategy in stroke patients. this proposed combined approach might be a novel combination of enhancing movement performance, daily function and quality of life for patients with stroke. this project will further explore the possible neuro-muscular mechanism underlying this combined mirror priming with robotic training. this project attempts to compare the cortical activation and neuromuscular control of patients with stroke and age-matched healthy adults in terms of electroencephalography (eeg) and muscle tone measurement. the findings of this study may lay an evidence-based foundation for bridging basic science and clinical application.

Eligibility criteria:
inclusion criteria: * stroke more than 3 months. * modified ashworth scale proximal part ≤ 3, modified ashworth scale distal part ≤ 2, and no serious muscle spasms. * the myoelectric signal can be detected to activate the instrument * unilateral paresis (fma score\<60) * no serious cognitive impairment (i.e., mini mental state exam score \> 24) * can provide informed consent exclusion criteria: * other neurological disease * complete sense of body defect * inability to understand instructions * current participation in any other research * botulinum toxin injection within 3 months

Keywords: robot assisted therapy mirror priming upper limb neuromuscular mechanism