Kornimate/medical-research-clean huggingface dataset:
performance of toric silicone hydrogel contact lenses following one month of daily wear

Conditions: Astigmatism

Summary: the aim of this prospective study is to evaluate the clinical performance of fanfilcon a toric and lotrafilcon b toric contact lenses after 1 month of wear in each pair.

the aim of this prospective study is to evaluate the clinical performance of avaira vitality toric (fanfilcon a) and air optix for astigmatism (lotrafilcon b) contact lenses after 1 month of wear in each pair.

Eligibility criteria:
inclusion criteria: * is between 18 and 40 years of age (inclusive) * has had a self-reported visual exam in the last two years * is an adapted soft contact lens wearer * has a contact lens spherical prescription between +6.00 to - 9.00 (inclusive) * have no less than -0.75d of astigmatism and no more than -2.25 d in both eyes. * can achieve best corrected spectacle distance visual acuity of 20/25 (0.10 logmar) or better in each eye. * can achieve a distance visual acuity of 20/30 (0.18 logmar) or better in each eye with the study contact lenses. * has clear corneas and no active ocular disease * has read, understood and signed the information consent letter. * patient contact lens refraction should fit within the available parameters of the study lenses. * is willing to comply with the wear schedule (at least 5 days per week, \> 8 hours/day assuming there are no contraindications for doing so). * is willing to comply with the visit schedule exclusion criteria: a person will be excluded from the study if he/she: * has a cl prescription outside the range of the available parameters of the study lenses. * has a spectacle cylinder less than -0.75d or more than -2.50 d of cylinder in either eye. * has a history of not achieving comfortable cl wear (5 days per week; \> 8 hours/day) * has contact lens best corrected distance vision worse than 20/25 (0.10 logmar) in either eye. * presence of clinically significant (grade 2-4) anterior segment abnormalities * presence of ocular or systemic disease or need of medications which might interfere with contact lens wear. * slit lamp findings that would contraindicate contact lens wear such as: * pathological dry eye or associated findings * pterygium, pinguecula, or corneal scars within the visual axis * neovascularization \> 0.75 mm in from of the limbus * giant papillary conjunctivitis (gcp) worse than grade 1 * anterior uveitis or iritis (past or present) * seborrheic eczema, seborrheic conjunctivitis * history of corneal ulcers or fungal infections * poor personal hygiene * has a known history of corneal hypoesthesia (reduced corneal sensitivity) * has aphakia, keratoconus or a highly irregular cornea. * has presbyopia or has dependence on spectacles for near work over the contact lenses. * has undergone corneal refractive surgery. * is participating in any other type of eye related clinical or research study.
post-authorization long-term safety study of lutathera

Conditions: Neuroendocrine Tumors

Summary: study to assess the long-term safety of lutathera for the labeled indication (smpc/uspi).

to assess the incidence and nature of potential long-term safety outcomes in patients with unresectable or metastatic, well-differentiated, somatostatin receptor positive gastroenteropancreatic neuroendocrine tumours. retrospective and prospective data will be used.

Eligibility criteria:
inclusion criteria: * adult patients (fulfilling the definition of "age of majority" per local regulations), * with unresectable or metastatic, well-differentiated, somatostatin receptor positive gep-nets * and who were treated with lutathera (regardless of the quantity and number of doses administered and whatever the reasons for ending). exclusion criteria: * hypersensitivity to lutathera (active substance or any of the excipients), * presence of established or suspected pregnancy or pregnancy not excluded, * presence of kidney failure with creatinine clearance \< 30 ml/min.

Keywords: gastroenteropancreatic neuroendocrine tumours
study evaluating pd-0299685 for the treatment of vasomotor symptoms (hot flashes / flushes) associated with menopause

Conditions: Hot Flashes

Summary: the primary purpose of this study is to determine if pd-0299685 is effective and safe in the treatment of vasomotor symptoms (hot flashes / flushes) associated with menopause.


Eligibility criteria:
inclusion criteria: * postmenopausal as defined by 6 months of spontaneous amenorrhea with serum fsh levels \>40mlu/ml and estradiol \ 40 mlu/ml and estradiol \< than = 25 pg/ml * women reporting at least 50 moderate to severe vasomotor symptoms per week, recorded for seven consecutive days * aged 40 to 70 years exclusion criteria: * no estrogen monotherapy or estrogen/progesterone containing drug products within applicable wash out period prior to screening * use of serms, clonidine within 4 weeks of screening * use of cns active medication within 1 week of screening * use of medications (ssri; snri), herbal or dietary supplements, including black cohosh, soy, phytoestrogens or over the counter agent known to possibly be effective for the treatment of vasomotor symptoms, within 4 weeks of screening * participation in clinical trial within 30 days * significant medical or psychiatric illness within past 12 months
investigation of the effects of physical activity in women at risk of osteoporosis

Conditions: Osteoporosis Risk

Summary: the goal of this clinical trial is to investigate the effects of the increase in the physical activity level of women at risk for osteoporosis in the post-menopausal period on the physical fitness, functional fitness age and quality of life. the main question it aims to answer is: • does the increase in the level of physical activity positively affect the physical fitness parameters (strength, endurance, balance, agility and flexibility), functional fitness ages and quality of life of post-menopausal women with moderate to high osteoporosis risk? participants in the intervention group were given the otago exercise program, which will last 3 days a week and an average of 30 minutes per day for 12 weeks. the exercises were done one-by-one with a physiotherapist. no program were applied to the participants in the control group, and they were asked to continue their daily living activities in the same way. researchers will compare two groups to see if there is a difference in effects of otogo exercise program on physical fitness, functional fitness age, and quality of life.

the osteoporosis risks of the participants were calculated according to the osteoporosis self-assessment tool for women (ost). women have medium and high risk were included in the study. otago exercise program includes strengthening exercises consisting of knee extension, knee flexion, hip abduction, ankle dorsi flexion, and 12 balance exercises consisting of plantar flexion and squatting, walking backward, walking and rolling back, sideways walking, tandem stance, tandem gait, standing on one leg, heels walking on toes, walking on tiptoe, sitting and standing, climbing and descending stairs, and backward tandem walking. • in addition, moderate-intensity walking exercise for 30 minutes a day, 2 days a week, was recommended to the patients in experimental group.

Eligibility criteria:
inclusion criteria: * being at medium-high risk as a result of the osteoporosis self-assessment tool for women (ost) * being 54 years old and over * being in the post-menopausal period exclusion criteria: * having a broken history * having a history of surgery in the last 1 year * having a cognitive or physical condition that will prevent them from exercising * exercising regularly for more than 30 minutes a day, at least 3 days a week

Keywords: functional fitness age osteoporosis otago exercise program post-menopausal woman quality of life physical fitness
thiol/disulphide homeostasis and albumin in vertigo

Conditions: Vertigo, Peripheral; Vertigo, Central Origin; Oxidative Stress; Diagnosis

Summary: vertigo is a common complaint in the emergency department (ed). the differential diagnosis of central and peripheral vertigo is a difficult issue that directly affects mortality. magnetic resonance imaging (mri) is the preferred diagnostic tool, but may not be suitable in all patients due to logistic and economic conditions. in this study, the investigators evaluated the role of thiol/disulfide homeostasis (tdh) parameters and ischemia modified albumin (ima) levels to assist in the value of being used instead of mri.

the study was conducted in the ed using a prospective, non-randomized method, and included patients with complaints of acute onset vertigo over 18 years of age and who underwent brain mri. pregnant women, smokers, and those with significant neurological signs were excluded. patients with acute ischemia with mri were included in the central vertigo group, and patients with normal mri were included in the peripheral vertigo group. blood samples for native thiol (nt), total thiol (tt), disulfide, and ima were collected from all patients at admission. statistical analyzes were performed with ibm spss statistics for windows 16.0 package program.

Eligibility criteria:
inclusion criteria: * patients with complaint of vertigo * patients over18 years of age exclusion criteria: * patients contraindicated for mri due to metal prosthesis or claustrophobia * patients under 18 years of age * pregnant patients * tobacco users * patients exhibiting significant neurological signs or symptoms such as motor or sensory neurologic deficit, speech disorders, unconsciousness, or seizure * patients found to have any type of lesion such as a hematoma, mass, cyst, aneurysm, arteriovenous malformation, etc. other than ischemic infarcts on mri * patients with an ischemic lesion other than posterior fossa lesions * patients with any type of infection, including upper respiratory tract and ear infections * patients previously diagnosed with peripheral vertigo * patients where the cause of lightheadedness was blood pressure disorders, cardiac ischemic and arrhythmic disorders, thromboembolic diseases, metabolic disorders, trauma, etc. rather than central and peripheral vertigo.

Keywords: vertigo central vertigo peripheral vertigo thiol/disulfide homeostasis ischemia modified albumin differential diagnosis
effect of biphasic insulin aspart 30 combined with metformin on blood glucose control in subjects with type 2 diabetes inadequately controlled with basal insulin

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in asia. this single arm trial aims to evaluate the blood glucose control with twice daily biphasic insulin aspart 30 in combination with metformin in chinese subjects with type 2 diabetes inadequately controlled with once or twice daily basal insulin.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * currently treated with basal insulin once or twice daily with or without oral anti-diabetic drugs (oads) for at least 3 months * hba1c (glycosylated haemoglobin a1c) within the range of 7.5% to10.0% ( both inclusive) * bmi (body mass index) maximum 40 kg/m2 exclusion criteria: * metformin contraindications according to local practice * systemically treated with tzds (thiazolidinediones) for more than one month within 6 months prior to this trial
ultrasound-guided esp block vs. wound infiltration in lumbar surgery: a comparative analysis (esp:erector spinae plane)

Conditions: Lumbar Spinal Stenosis; Lumbar Spine Instability; Lumbar Spine Degeneration

Summary: this study aimed to compare the efficacy of ultrasound-guided erector spinae plane block (espb) with that of wound infiltration (wi) for postoperative analgesia in lumbar spinal surgeries involving instrumentation.

in this randomized controlled trial, 80 patients were divided into two groups: espb (n=40) and wi (n=40). postoperative pain intensity was assessed using the visual analog scale (vas) at multiple time points within 24 hours. additionally, opioid consumption, time to first rescue analgesia, incidence of postoperative nausea and vomiting (ponv), and patient satisfaction were evaluated.

Eligibility criteria:
inclusion criteria: * elective lumbar spine surgery involving instrumentation * asa physical status i-iii * ability to provide informed consent exclusion criteria: * known allergies to local anesthetics * coagulopathy or anticoagulant therapy * infection at the injection site * preexisting neurological disorders affecting sensory perception * pregnancy * inability to understand the visual analog scale (vas) for pain assessment

Keywords: erector spinae plane block wound infiltration postoperative analgesia lumbar spinal surgery ultrasound-guided anesthesia postoperative pain visual analog scale (vas) enhanced recovery after surgery (eras)
unexpected cardiac arrest in intensive care unit

Conditions: Heart Arrest

Summary: unexpected cardiac arrest involves approximately 0.5 to 5% of patients admitted in intensive care unit (icu). even if they have a technical environment conducive to prompt diagnosis and prompt treatment, patients hospitalized in icu suffer from chronic illnesses and organ failure(s) that obscure the prognosis of cardiac arrest. although extra cardiac arrhythmias or intra-hospital arrests are the subject of numerous publications, few studies specifically focus on unexpected cardiac arrest in icu (none in france). the objective of our work is to produce a prospective epidemiological description of unexpected cardiac arrest in in french icus.

unexpected cardiac arrest in icu corresponds to cardiovascular arrest leading to at least one cardiopulmonary resuscitation technique (external cardiac massage and / or electric shock). they account for about 0.5 to 5% of admissions to intensive care units. even if they benefit from a technical environment conducive to prompt diagnosis and rapid management, resuscitated patients suffer from chronic diseases and organ failure (s) that darken the prognosis. etiologies of unexpected cardiac arrest in icu are rarely described in the literature. their specificity comes from the fact that they can be related to patient's medical characteristics, but also to deleterious effects of supportive techniques in place at the time of circulatory arrest (respiratory assistance, vasopressor drugs, extracorporeal circulation ...). these same techniques may also reduce the effectiveness of cardiopulmonary resuscitation (cardiorespiratory interactions of respiratory assistance, pro-arrhythmogenic effect of vasopressor drugs, haemodynamic repercussion of extracorporeal circulation). although cardiac arrests have been published extensively out of or in-hospital, there are few studies specifically concerning unexpected cardiac arrest in icu (none in france). the prognosis is different: after an unexpected cardiac arrest in icu, 50% of the patients recover a spontaneous cardiac activity but only 15% leave alive from the hospital (3 to 4% with a good functional autonomy). a prospective description of risk factors, circumstances and consequences in the medium term would identify (and prevent) risky situations and identify, among those at risk for unexpected cardiac arrest, those for whom a cardiopulmonary resuscitation is justified.

Eligibility criteria:
inclusion criteria: * patient with unexpected cardiac arrest during his / her hospitalization in the icu * patients who have benefited from at least one basic cardiopulmonary resuscitation technique by the icu team to treat this circulatory arrest (external electric shock, external cardiac massage, adrenaline injection ...) * patients with multiple unexpected cardiac arrest during hospitalization will be included only for the first circulatory arrest. exclusion criteria: * patients with unexpected cardiac that have not been resuscitated. * patients in cardiac arrest at admission to icu
profiling antibody status and vaccine effectiveness in post vaccination with sars cov2 in ain shams university

Conditions: Covid19

Summary: this is a prospective intervention study to assess the effectiveness of both the live attenuated and messenger rna vaccines against sars-cov-2 infection

this is a prospective intervention study to assess the short-term effectiveness of the first dose of both the live attenuated and messenger rna vaccines against sars-cov-2 infection by monitoring the antibodies (igg, igm and level of neutralizing antibodies) in sera of post-vaccinated persons. the study also will monitor the incidence of sars-cov-2 infection among vaccinees just before the first dose administration, 3 weeks after immunization, at the administration of the second dose, 14 days following the second dose and after 3 and 6 months.

Eligibility criteria:
inclusion criteria: 1. age \> 18 years old 2. candidate for receiving vaccination according to health care authorties prioritaizaton exclusion criteria: 1. sars-cov-2 recovered cases \<3 months 2. individuals who are currently infected with sars-cov-2 and/or with respiratory symptoms with fever.

Keywords: egypt ain shams university vaccine
hemostasis of active gastrointestinal (gi) luminal tract bleeding

Conditions: Bleeding Peptic Ulcers

Summary: the objective of this study is to show that hemospray is effective in achieving initial hemostasis and documenting rate of further bleed when compared to standard of care.


Eligibility criteria:
inclusion criteria: * bleeding peptic ulcer exclusion criteria: * patient is: \< 18 years of age * patient is unable to consent * patient is contraindicated to undergo endoscopy * patient has: coagulopathy, altered post surgical anatomy of the stomach, previously placed intrahepatic portosystemic shunt * patient is pregnant or lactating * patinet has an inr \> 2.5

Keywords: endoscopic hemostasis peptic ulcer recurrent bleeding injection therapy thermal probe
prophylactic mesh implantation in patients with peritonitis for the prevention of incisional hernia

Conditions: Peritonitis; Incisional Hernia; Surgery

Summary: in patients undergoing laparotomy, the incidence of abdominal wall related complications such as incisional hernia is very high. in particular in patients with peritonitis undergoing laparotomy the incidence of incisional hernia is up to 54.3%. furthermore, these patients are at great risk for development of postoperative fascial dehiscence. the gold standard of abdominal wall closure is a running slowly absorbable suture irrespective of the presence of peritonitis. implantation of an intraperitoneal mesh potentially reduces the incidence of incisional hernia. in a series of high risk patients in which we implanted non-absorbable intraperitoneal mesh prophylactically we reduced the incidence of incisional hernia down to 3.2%.

background incisional hernia is a common complication in visceral surgery and varies between 11 and 26% in the general surgical population \[1,2\]. an incisional hernia is defined as any abdominal wall gap with or without a bulge in the area of postoperative scar perceptible or palpable by clinical examination or imaging \[3\]. overall incidence of incisional hernia at our institution with a follow-up of five years was 14%, whereas in patients undergoing liver transplantation we found an incidence of incisional hernia of 25% in a prospective study \[2\]. however, patients with peritonitis are at very high risk for the development of incisional hernia. moussavian et al demonstrated an incidence of incisional hernia of 54.3% after a median follow-up of 6 years in patients undergoing emergency surgery for secondary peritonitis \[4\]. in patients undergoing surgical therapy for secondary peritonitis, redo surgery because of complications associated with the abdominal wall, such as fascial dehiscence and surgical site infection are frequent. impaired wound healing in response to the systemic inflammatory response and the high incidence of surgical site infection might render the abdominal wall even more susceptible for incisional hernia, compared with the general surgical population \[5,6\]. furthermore, patients with peritonitis undergoing emergency laparotomy develop fascial dehiscence in up to 24.1% \[7\]. fascial dehiscence requires reoperation and is associated with a mortality rate up to 44% \[8\]. objective to compare prophylactic mesh implantation to conventional abdominal wall closure in patients undergoing emergency laparotomy for peritonitis. methods implantation of a non-resorbable intraperitoneal mesh in patients with peritonitis undergoing emergency laparotomy.

Eligibility criteria:
inclusion criteria: * patients with clinical signs of peritonitis * emergency laparotomy or laparoscopy with conversion to laparotomy * patients \> 18 years * written informed consent exclusion criteria * previous implanted mesh * incisional hernia present * small bowel obstruction without bowel resection * surgery for cholecystitis * inflammatory bowel disease (crohn's disease, ulcerative colitis) * polytrauma patients * pregnant women * women younger than 45 years
minimum effective local anesthetic volume for ultrasound guided superior trunk block

Conditions: Musculoskeletal Diseases or Conditions

Summary: the objective of this study is to identify the minimum effective dosage of a commonly used local anaesthetic drug "levobupivacaine" required to produce an effective ultrasound guided (usg) superior trunk block (stb) in at least 90% of patients for shoulder arthroscopic surgeries.

shoulder arthroscopic surgery is one of the most commonly performed procedures worldwide, and associated with significant postoperative pain. currently, such surgery is performed either under general anaesthesia or under interscalene brachial plexus block (isbpb), which is a regional anaesthesia technique. however, isbpb is associated with the highest incidence of hemi-diaphragmatic palsy of the operative side. since majority of the innervation to the shoulder arises from or passes through the superior trunk of the brachial plexus, superior trunk block has been shown to have lesser impact on the phrenic nerve and it has been gaining popularity worldwide. ultrasound is widely used for brachial plexus block and current evidence indicates that it is feasible to accurately identify majority of the main components of the brachial plexus above the clavicle, including the three trunks (superior, middle, and inferior trunks). however, there are no data describing an optimal volume of local anaesthetic for superior trunk block. the aim of this study is to identify the minimum effective dosage of a commonly used local anaesthetic drug "levobupivacaine" required to produce an effective ultrasound guided (usg) superior trunk block (stb) in at least 90% of patients for shoulder arthroscopic surgeries.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) physical status i-iii scheduled to undergo elective upper shoulder arthroscopic rotator cuff repair procedure exclusion criteria: * patient refusal * pregnancy * skin infection at the site of block placement * history of allergy to local anaesthetic drugs * bleeding tendency or with evidence of coagulopathy * pre-existing neurological deficit or neuromuscular disease.

Keywords: superior trunk nerve block