Kornimate/medical-research-clean huggingface dataset:
use of human dehydrated amnion/chorion (dhacm) allograft in partial nephrectomy

Conditions: Partial Nephrectomy; Kidney Cancer; Renal Function Aggravated

Summary: after partial nephrectomy, kidney function decreases by about 10% overall and by about 20% in the operated kidney. this is primarily due to the loss of healthy parenchymal volume during resection of the tumor. in an effort to preserve and regenerate healthy parenchyma during the procedure and ultimately renal function after partial nephrectomy, the single center double arm single-blinded randomized screening clinical trial will evaluate the ability of human amnion/chorion allograft to facilitate the recovery of renal function following robotic partial nephrectomy.

to determine whether amniofix facilitates improved recovery of renal function at 12 months.

Eligibility criteria:
inclusion criteria: * any individual with a diagnosis of a renal mass. * all patients undergoing partial nephrectomy as their definitive treatment for their renal mass. * ability to understand and the willingness to sign a written informed consent. * patients with a solitary clinical t1a renal mass. exclusion criteria: * patients undergoing radical nephrectomy as their definitive treatment for their renal mass. * patients with transitional cell carcinoma. * patients with known hereditary syndromes such von hippel-lindau (vhl) syndrome, lynch syndrome, birt-hogg-dube syndrome. * patients with metastatic disease undergoing cytoreductive nephrectomy as their definitive treatment for metastatic disease. * patients with prior kidney surgery. * patients with a solitary or horseshoe kidney. * patients with a positive margin found during intra-operative frozen section done only when clinically indicated (i.e., macroscopic abnormality identified). * patients with multiple renal masses. * patients with greater than a clinical t1a renal mass.
clinical study of attr-cm

Conditions: Transthyroxine Amyloidosis Cardiomyopathy

Summary: in this study, patients with attr-cm or gene carriers were selected to study the diagnosis and treatment, and long-term follow-up was conducted.


Eligibility criteria:
inclusion criteria: * patients and gene carriers of attr-cm confirmed in the second affiliated hospital of zhejiang university school of medicine, regardless of gender, age 18-90 years old; * patients who have the ability to understand the test and can cooperate with investigators exclusion criteria: * patients who unable to understand or unwilling to fill in informed consent forms or follow visitors
positron emission tomography (pet) study with [11c]raclopride to determine central d2 dopamine occupancy of seroquel

Conditions: Depression

Summary: the aim of this study is to relate pharmacokinetics of two different formulations of quetiapine to pet measured receptor occupancy in the brains of healthy subjects.


Eligibility criteria:
inclusion criteria: * normal mri scan * body mass index 19-30 kg/m2 and weight of 50-100 kg * clinically normal physical findings, medical history and laboratory values exclusion criteria: * trauma or sickness last 2 weeks before the first pet examination. * a history or presence of neurological, haematological, psychiatric, gastrointestinal, hepatic, pulmonary, renal disease or other condition as judged by the investigator * any previous participation in a pet study * subjects suffer from claustrophobia

Keywords: pet phase 1 depression seroquel positron emission tomography drug profile comparison
autonomic testing in subclinical carotid atherosclerosis

Conditions: Subclinical Carotid Atherosclerosis

Summary: background: atherosclerotic carotid intima-media thickness (imt) may be associated with alterations in the sensitivity of carotid and subclavian baroreceptors. aim: the aim of this study is to investigate if carotid imt is associated with changes in the autonomic modulation of the heart rate variability (hrv). methods: this is a prospective cross-sectional study. the carotid imt is determined by b-mode and duplex ultrasonography. the cardiovagal function was determined through linear and nonlinear measures of hrv. linear regression models, adjusted for demographics, comorbidities, body mass index, waist-hip-ratio, and left ventricular ejection fraction will be used to evaluate the association between hrv parameters and carotid imt.


Eligibility criteria:
inclusion criteria: * asymptomatic patients aged 18 years and older without a history of transient ischemic attack, stroke, or other neurologic signs or symptoms are selected to participate in the study. exclusion criteria: * patients with symptomatic carotid artery stenosis were excluded if the patient had transient or permanent focal neurologic symptoms related to the ipsilateral retina or the cerebral hemisphere. * patients with heart rhythm disorders, pacemaker, heart failure, ejection fraction less than 0.45, chronic renal failure on hemodialysis, severe liver failure, myocardial infarction, endarterectomy, carotid angioplasty, carotid dissection and carotid occlusion were excluded. * patients receiving drugs known to interfere with autonomic function, such as beta-blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, vasodilators, statins, neuroleptics and nasal vasoconstrictors, were discontinued for 24 hours before the tests.
pain control after cardiac surgery using intravenous acetaminophen

Conditions: Pain

Summary: evaluate the efficacy of iv acetaminophen; compared to a placebo, in reducing opioid consumption and/or pain intensity scores after cardiac surgery.


Eligibility criteria:
inclusion criteria: * - males or females 18 years of age or older. * non-emergency cardiac surgery via a midline sternotomy at cleveland clinic main campus. exclusion criteria: 1. redo cardiac surgery. 2. combined cabg (coronary artery bypass graft)\& valve replacement, multiple valve replacements, ascending aortic or aortic arch surgery. 3. weight \ 38 kg/m2. 4. left ventricle ef ¡ü 35% ,right ventricular moderate or severe dysfunction. 5. severe (3-4 +) tricuspid regurgitation. 6. recent stroke (within 6 months). 7. severe lung disease requiring home o2 therapy. 8. preoperative renal insufficiency (creatinine \> 2.0) or on dialysis. 9. history of liver cirrhosis or active liver disease. 10. chronic pain conditions controlled by preoperative opioid administration. 11. known allergy to acetaminophen or fentanyl.

Keywords: males or females 18 years of age or older. non-emergency cardiac surgery midline sternotomy.
the effect of intrarectal ice application on pain, anxiety, cortisol level, complication development in transrectal ultrasonography guided prostate biopsy

Conditions: Transrectal Ultrasound (TRUS)-Guided Prostate Biopsy

Summary: transrectal ultrasound (trus)-guided prostate biopsy is one of the most commonly performed urological procedures today. this technique involves the insertion of a needle through the rectal mucosa to access the prostate. while trus-guided biopsy demonstrates a high detection rate for prostate cancer, it also carries a significant risk of post-procedural complications, such as hematuria, rectal bleeding, urinary retention, and anemia. compared to other biopsy methods, trus-guided biopsy is associated with higher rates of hospital readmissions and an increased risk of infection and sepsis. these complications contribute to elevated healthcare costs, prolonged hospital stays, increased workload for healthcare providers, heightened patient stress and anxiety levels, greater analgesic requirements, the potential for additional complications, and reduced patient satisfaction. various non-pharmacological methods have been shown to be effective in preventing these adverse patient outcomes. one such method, which has been identified in the literature as effective, is cold application. cold application is a widely preferred non-pharmacological intervention due to its simplicity, affordability, and accessibility. it is particularly used to reduce acute pain, edema, and bleeding. cold therapy slows down metabolism, thereby reducing the oxygen and nutrient demands of tissues; it also limits inflammation, muscle spasm, and edema, alleviates pressure and tension on nerve endings, and decreases the conduction velocity of peripheral nerves. these effects contribute to a reduction in patients' pain, anxiety associated with pain, and bleeding. the aim of this study is to determine the effects of intrarectal ice application during transrectal ultrasound-guided prostate biopsy on pain, anxiety, cortisol levels, the incidence of complications, and hospital readmission rates.


Eligibility criteria:
inclusion criteria: * patients who agree to participate in the study, * patients over the age of 18 * patients who are conscious, oriented, and cooperative, * patients who have no communication problems, * patients who are scheduled to undergo their first prostate biopsy under transrectal ultrasound guidance, * patients who have no mental disorders, * patients who have not been diagnosed with anxiety disorder, * patients not taking medication for anxiety control. exclusion criteria: * patients who refuse to participate in the study, * patients under the age of 18 * patients who are conscious, oriented, and uncooperative, * patients with communication problems, * patients who have not undergone transrectal ultrasound-guided prostate biopsy, * patients who have previously undergone prostate biopsy, * patients with mental disorders, * patients diagnosed with anxiety disorder, * patients taking medication for anxiety control.

Keywords: transrectal ultrasound (trus)-guided prostate biopsy intrarectal ice application pain, anxiety, cortisol levels
rapid atrial fibrillation treatment strategy

Conditions: New Onset Atrial Fibrillation; Sepsis; Respiratory Failure

Summary: prospective, randomized, open-label clinical trial studying the treatment of new onset atrial fibrillation in critically ill patients with septic shock. patients will be assigned to rhythm vs rate control strategies with various outcome measures assessed.

data have demonstrated that critically ill patients with septic shock who develop atrial fibrillation suffer a greater likelihood of death and other complications when compared with patients who remain in sinus rhythm, however, little evidence exists to inform treatment strategies in this population. ours is a pilot study evaluating rhythm vs rate control strategies in patients with septic shock and respiratory failure requiring invasive mechanical ventilation who develop new onset atrial fibrillation (noaf). design will be prospective, randomized, open-label. patients in the rhythm control arm will receive iv amiodarone infusion followed by attempt at electrical cardioversion within 24 hours development of noaf. those in the rate control arm will receive negative chronotropic agents (beta blockers, calcium channel blockers, amiodarone, or digoxin) at the discretion of the treating physician. available patient data will be collected for a total of 180 days following enrollment, and outcomes assessed will include icu length of stay, ventilator free days, and time on vasopressors

Eligibility criteria:
inclusion criteria: * no history of atrial fibrillation * meet sepsis-3 criteria * new onset atrial fibrillation in the icu * atrial fibrillation treatment warranted * anticoagulation therapy not contraindicated * on a ventilator * patient or family member willing to provide informed consent to participate in study exclusion criteria: * post-cardiac or thoracic surgery * hemodynamically unstable * unable to tolerate anticoagulation * physician provider does not agree for patient to participate in study * patient or family member unwilling or unable to provide informed consent * expected death within 24 hours * non-english speakers

Keywords: new onsent atrial fibrillation sepsis critical care direct current cardioversion atrial fibrillation treatment
the role of social determinants in cardiovascular health and vascular function

Conditions: Social Determinants of Health; Major Depressive Disorder; Cardiovascular Diseases

Summary: this study aims to identify the influence of social determinants of health domains on vascular function in a low income, racial, and ethnic minority population at risk for disparities. we hypothesize that individuals of a lower social economic position and those struggling with depression are at greater risk of cardiovascular disease.

this study aims to identify the influence of social determinants of health domains on vascular function in a low income, racial, and ethnic minority population at risk for disparities. we hypothesize that individuals of a lower social economic position are at greater risk of impairment in the large organ that is responsible for blood movement in the body and artery stiffness. additional sims include identifying the influence of depression on vascular function and measure the interaction between depression and social determinants of health. we hypothesize that impairment will be greater in individuals with depression than in individuals without. finally we will compare a comprehensive metabolic project against the social determinants of health and depression, hypothesizing that more severe social determinants of health and depression will increase the risk of cardiovascular disease.

Eligibility criteria:
inclusion criteria: * age 18 or older and ability to read. exclusion criteria: * (1) unable to provide informed consent (e.g., due to acute impairment or psychosis), (2) inability to read, (3) previously enrolled in the study.
dermatologic manifestations of zika virus

Conditions: Zika Virus Symptoms and the Associated Exanthema

Summary: the purpose of this study is to determine whether any diagnostic patterns exist in the symptom presentation of zika virus.

the study has both retrospective and prospective components. the retrospective review includes medical records with laboratory confirmed zika virus diagnosis and the prospective component will enroll adults presenting with febrile illness and rash and ask them to complete a survey about their symptoms. diagnostic testing will be completed to confirm infection source.

Eligibility criteria:
inclusion criteria: * adults aged 18 years and older presenting with febrile illness and rash exclusion criteria: * patients aged 17 years or younger

Keywords: zika virus
evaluation of a point-of-care testing instrument for fecal immunochemical test

Conditions: Colorectal Cancer

Summary: early detecting and removing of colorectal advanced adenomas can reduce incidence of colorectal cancer.use of the fecal immunochemical test (fit) for colorectal cancer (crc) prevention is supported by previous studies.however existing instruments have low portability.the purpose of this study is to test the performance of a point-of-care testing instrument for fecal immunochemical test(fit) .

colorectal cancer (crc) is the third most common cancer worldwide and has become a progressively important public health problem that inevitably leads to an increase in morbidity and medical costs. therefore, many countries have a screening program in place to lower the incidence of crc. subjects with a positive fecal immunochemical test (fit) have a much higher likelihood of advanced neoplasms than the general population.however existing instruments have low portability.the purpose of this study is to test the performance of a point-of-care testing instrument for fecal immunochemical test (fit).

Eligibility criteria:
inclusion criteria: * people who use the new instrument for fecal immunochemical test(fit) * people sign an "informed consent form" exclusion criteria: * people with history of surgery in any part of the large bowel; * people with symptoms including visible rectal bleeding, hematuria, hemorrhoid bleeds, severe and acute diarrhea and 7th type stool (bristol feces score);
from skin fibroblasts to neural stem cells to investigate in vitro the impact of diabetes on adult neurogenesis

Conditions: Diabetes Mellitus, Type 2; Diabetes Mellitus Type 2 in Obese; Diabetes Mellitus Type 2 in Nonobese; Obesity; Cognitive Dysfunction; Metabolism Disorder

Summary: obesity and glucose intolerance or overt diabetes are increasing at an alarming rate in the population, and are bound to become a public health issue and a major cause of disability, loss of independence and high social costs in the near future. a large body of evidence has in recent years highlighted, among the negative effects of overnutrition and glucose dysmetabolism, also an acceleration of cognitive decline and of brain senescence, through cellular (vascular, neuronal, or both) and molecular mechanisms still incompletely clarified. understanding how overweight and impaired glucose homeostasis negatively affect brain function represents both a major scientific challenge and an avenue to early detection and possibly prevention of this invalidating complication. the aim of this project is to obtain neuronal progenitor-like cells from skin fibroblasts in order to correlate patient-specific metabolism to adult neural stem cell (nsc) and neuronal function in vitro.

* analysis of skin fibroblasts from normal, obese, lean/diabetic and obese/diabetic individuals and in vitro epigenetic conversion, as revealed by morphological changes, loss of mesenchymal markers and expression of pluripotency genes. * to re-differentiate patient-derived pluripotent cells into neural progenitor (np) and to test their proliferative, self-renewal and multilineage differentiation capacity. * to evaluate neuronal cells derived from patient and control pluripotent cells for a number functional and biochemical parameters (apoptosis/autophagy, mitochondrial potential, reactive oxygen species etc.) relevant to neurodegenerative disorders.

Eligibility criteria:
inclusion criteria: * patients of both sexes with bmi \ 30 (obese) with or without t2dm with an indication for surgery exclusion criteria: * malignant neoplastic diseases
hema free versus hema containing adhesives in posterior restorations

Conditions: Dental Caries

Summary: the aim of study is to evaluate the clinical performance of posterior restorations using hema free universal adhesive versus hema containing universal adhesive over one year using usphs criteria.

the study is intended to evaluate the hema free universal adhesive versus hema containing universal adhesive when both used in conjunction with giomer aesthetic restorations in occlusal cavities in posterior teeth icdas iii and iv. the restorations will be evaluated at baseline, 6 and 12 months according to modified usphs criteria in terms of marginal staining, marginal adaptation and caries recurrence. patients will be recruited from outpatient clinic of conservative dentistry department, cairo university according to inclusion and exclusion criteria. patient will be randomly allocated to intervention or control group.

Eligibility criteria:
inclusion criteria of participants: * patients with occlusal caries in molars classified as icdas iii or iv. * 19-35 years. * males or females. * co-operative patients approving to participate in the trial. exclusion criteria of participants: * pregnancy. * disabilities. * systemic disease or severe medical complications. * allergic history concerning methacrylate. * rampant caries. * heavy smoking. * xerostomia. * lack of compliance. * evidence of severe bruxism, clenching, or tempromandibular joint disorders.

Keywords: hema free hema containing adhesive giomers giomer usphs criteria
teleconference fatigue management for people with multiple sclerosis

Conditions: Multiple Sclerosis

Summary: approximately 60% of individuals with multiple sclerosis (ms) describe fatigue as their most disabling symptom. energy conservation education involves teaching people with ms different strategies to manage fatigue and reduce its impact on daily life. despite growing evidence of the effectiveness of face-to-face energy conservation education, not all people with ms are able to access these programs. the purpose of this project is to test the effectiveness and efficacy of a teleconference-delivered energy conservation education program for people with ms. the primary goals of the project are to reduce the impact of fatigue on participants' everyday lives, reduce fatigue severity, and improve quality of life. secondary goals are to increase self-efficacy for managing fatigue and increase the number of energy conservation strategies used. the study will employ a randomly allocated two group time series design with a wait-list control group, which is one type of randomized control trial. a total of 181 people with ms will be recruited through direct mailing and advertising. the program will be delivered by telephone teleconference by a licensed occupational therapist. outcome measures will be administered over the telephone by a research assistant before and after the program, at three months and at six months. we hypothesize that: (1) individuals in the immediate intervention group achieve better outcomes than individuals in the wait-list control group; (2) the program leads to significant reductions in fatigue impact and fatigue severity, and improved quality of life; and (3) improvements in the outcomes can be maintained over six months.


Eligibility criteria:
inclusion criteria: * a diagnosis of ms * 18 years of age or older * functional english literacy (i.e., able to read course materials and carry on telephone conservations in english) * fatigue severity scale score of 4 or greater * residing in the state of illinois exclusion criteria: * short version - blessed orientation memory concentration test - outside of normal range

Keywords: energy conservation education occupational therapy intervention fatigue management psychoeducation
study of combination docetaxel and radiotherapy with or without cisplatin to treat local advanced head and neck cancer

Conditions: Head and Neck Neoplasms

Summary: to evaluate the efficacy of the concomitant combination of radiotherapy and docetaxel with or without cisplatin in terms of objective response rates (who criteria).


Eligibility criteria:
inclusion criteria: * patients with locally advanced head and neck cancer (t3 and t4 tumors), epidermoid, histologically proven without metastasis; the primitive site of which is the oral cavity, the oropharynx, the hypopharynx or the larynx. * locally advanced tumors which are inoperable, or operable but the patient refuses surgery. * age ≥ 18 years and ≤ 70 years. * ps \< 2. * satisfactory hematological, hepatic and renal functions: (pn ≥ 2000/mm3, platelet count ≥ 100,000/mm3, hemoglobin ≥ 10g/dl, serum creatinine ≤ 120 µmol/l or creatinine clearance ≥ 60 ml/mn, normal total bilirubin, ast (sgot) and alt (sgpt) ≤ 2.5 x the upper limit of normal (uln) of each center, pal ≤ 5 x lns; patients with ast or alt \> 1.5 x lns combined with pal \> 2.5 x lns will not be eligible for this trial. exclusion criteria: * any metastases (other than cervical ganglia). * cancer of the cavum and the facial structure. * any previous chemotherapy or radiotherapy, irrespective of the reason. * any surgery for epidermoid carcinoma in the upper aerodigestive tracts. * weight loss ≥10% of total body weight during the last 3 months. * any other previous cancer excepting in situ or cutaneous cervical cancer (spinocellular or basocellular). * pregnant or nursing women; women of childbearing potential must use an appropriate method of contraception. * poorly controlled progressive infection. * peripheral neuropathy with nci grade ≥ 2. * neurological or psychiatric disease (dementia, seizures, etc.) that is not compatible with good understanding and sufficient compliance with treatment. * any other poorly controlled progressive disease, such as heart failure, symptomatic cardiac rhythm disorders, progressive angina pectoris, or respiratory impairment. * any other concomitant investigational treatment. * any other concomitant anticancer treatment. * allergy to polysorbate 80. * definitive formal contraindication to corticosteroids. the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.