Kornimate/medical-research-clean huggingface dataset:
dental health epidemiology among israel defense forces (idf) recruits

Conditions: Caries, Dental; Gingivitis; Fluorosis; Dental Trauma

Summary: an epidemiological survey for prevalence description of dental morbidity (caries, gingivitis, dental trauma and fluorosis) among israel defense forces (idf) general recruits. morbidity measures were collected from 700 recruits at their first day of military service in order to evaluate extent and burden of dental diseases among recruits. the data will enable the military dental services commanders to plan and implement dental services according to the dental needs.

caries, gingivitis, dental trauma and fluorosis epidemiological measures were collected among idf recruits in 700 sample using short clinical evaluation without radiographs. water fluoridation ecological data will be obtained from the ministry of health. the results might impact dental services plan, professional manpower system, and the layout of the dental clinics in the idf. it will give the professionals in the military dental services an evidence based data for planning an accurate primary and secondary prevention programs and an evaluation of dental diseases burden in order to have the "full picture" of recruits dental needs. .

Eligibility criteria:
inclusion criteria: * above 18 years old. exclusion criteria: * chronic bone diseases. * mineralization defects
interest of the pleth variability index in neurosurgery

Conditions: Intraoperative Monitoring; Hypovolemia; Fluid Challenge

Summary: this clinical trial aims to study the interest of the pleth variability index (pvi) to evaluate perioperative fluid responsiveness in neurosurgery in adults. the main question it aims to answer is: • does the pleth variability index predict fluid responsiveness in neurosurgery? researchers will compare the pleth variability index to dela pp to see if it predicts fluid responsiveness in neurosurgery. once participants give their consent, they will be randomly assigned to one of two groups. in one group, fluid responsiveness will be monitored using the pleth variability index, while in the other group, it will be monitored using delta pp.


Eligibility criteria:
inclusion criteria: 1. patients proposed for intracranial surgery 2. must be aged 18 and over 3. must be classified as asa i, asa ii, and asa iii according to the american society of anesthesiologists classification exclusion criteria: 1. non-consenting patients 2. patients classified asa iv or higher 3. cardiac arrhythmia 4. heart disease with left ventricular ejection fraction less than 45% 5. obesity with a bmi greater than 40 kg/m2. 6. peripheral vascular disease 7. severe lung disease 8. end-stage renal disease 9. intraoperative cardiac arrhythmia 10. the occurrence of cardiac arrest 11. the occurrence of hemorrhagic shock 12. intraoperative use of low tidal volumes or high respiratory rates.
study to assess the efficacy/safety of transdermal testosterone patches in naturally menopausal women with low libido

Conditions: Hypoactive Sexual Desire Disorder (HSDD)

Summary: this study is designed to evaluate efficacy and safety of a testosterone patch as treatment for low libido in naturally menopausal women who are taking estrogen or estrogen/progestin therapy.

naturally menopausal women with hypoactive sexual desire disorder (hsdd) were randomized into a 24-week, multicenter, multinational, double-blind (db), parallel-group, placebo-controlled study. patients were randomized to receive a placebo or testosterone transdermal system throughout the study. safety was assessed by adverse events, lipids, serum chemistry with hepatic, renal and carbohydrate metabolism evaluation, and hematology. physical exam including clinical assessments of facial hair and acne were monitored.

Eligibility criteria:
inclusion criteria: eligible women must: 1. be 40-70 years old and in generally good health 2. be post-menopausal with no spontaneous periods for 1 year 3. be receiving a stable dose of hormone replacement therapy for at least 3 months pror to screening with the intention of maintaining that regimen. 4. be, in her own judgment, in a stable, monogamous sexual relationship that is perceived to be secure and communicative, for at least one year prior to study entry 5. meet the criteria for having hypoactive sexual desire disorder exclusion criteria: eligible women must not: 1. have received androgen therapy at any time during the past 3 months (during the past 7 months if therapy was an investigational implantable product) 2. be experiencing any chronic or acute life stress relating to any major life change 3. be experiencing depression and/or receiving medication for such illness or disorder 4. have current severe skin problems (such as severe or cystic acne) or allergy to adhesives (like the ones in bandages) 5. have had a major illness, active gall bladder disease, or gynecological or breast surgery within the last 6 months 6. have a history of breast, endometrial, or other gynecological cancer at any time before study participation or other cancer within the last 5 years 7. have diabetes, a history of cerebrovascular disease, thrombo-embolic disorders, heart attack, or angina at any time before study participation or thrombophlebitis within the last 5 years 8. have abnormal laboratory test results upon initial screening for this study 9. have previously participated in a clinical trial within 30 days or received an investigational medication within 30 days

Keywords: natural menopause
blood glucose awareness training for parents

Conditions: Diabetes Mellitus, Type 1

Summary: the purpose of this study is to test a training program for parents of children with t1dm.

successful diabetes management relies on a process of self-regulation in which treatment behavior is guided by feedback about changing blood glucose (bg) levels and decision-making. the processes involved in self-regulation have been studied extensively in adults with type 1 diabetes mellitus (t1dm), leading to the development of sophisticated research tools that have significantly advanced our understanding and ability to predict clinical outcome. additionally, this research has led to the development of a highly effective, empirically based,pyschobehavioral intervention, blood glucose awareness training (bgat) that improves self-regulation and clinical outcome in adults with t1dm. unfortunately, the processes involved in the self-regulation of pediatric diabetes have received virtually no empirical attention. the purpose of this project is to correct the scientific neglect of the self-regulation in pediatric diabetes by adapting the conceptual and methodological tools used in adult studies to investigate the process of diabetes regulation by school-aged children (6-11 years) with t1dm and their parents and to develop and test an intervention to enhance the skills critical to this process.

Eligibility criteria:
inclusion criteria: * parent/guardian with primary responsibility for a child's diabetes management * child with t1dm between the ages 6 - 11 years. * duration of child's diabetes \> 1 year * routine self-testing of child's bg \> 2x day * intention to remain in the study's geographical region for the next 5 months * have a computer at home exclusion criteria: * significant comorbidity in the child that could interfere with bg awareness or psychosocial status * medications taken by the child that interfere with symptom perception * psychiatric disorder in a parent or child * cognitive deficits/learning disabilities in the child that might preclude ability to complete the study protocol.

Keywords: bg perception hypoglycemic awareness pediatric t1dm
evaluation of pediatric measles cases in 2019: single-center experience

Conditions: Measles

Summary: measles, can be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. as a result of the world health organization (who) and united nations international children's emergency fund (unicef) strategic plans, the annual global incidence of measles decreased by 75% over the period 2000-2015, and the estimated global mortality rate fell by 73%. for the current 2019 period, the european and the eastern mediterranean region has recorded respectively more than two-fold and 1.5-fold increase in reported measles cases. as it is known, no specific antiviral treatment exists for the measles virus therefore, vaccination is still the most effective method of preventing disease. the aim of this study was to evaluate the measles cases in districts where the refugees live quite intensely.

measles, can be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. as a result of the world health organization (who) and united nations international children's emergency fund (unicef) strategic plans, the annual global incidence of measles decreased by 75% over the period 2000-2015, and the estimated global mortality rate fell by 73%. for the current 2019 period, the european and the eastern mediterranean region has recorded respectively more than two-fold and 1.5-fold increase in reported measles cases. as it is known, no specific antiviral treatment exists for the measles virus therefore, vaccination is still the most effective method of preventing disease. the aim of this study was to evaluate the measles cases in districts where the refugees live quite intensely. this retrospective study was consecutively enrolled children who were considered as suspicious measles case according to with clinical features and attended in esenler gynecology and pediatrics hospital pediatric clinic between 01 january-30 june 2019.

Eligibility criteria:
inclusion criteria: * the suspicious case of measles * measles/rubella case notification and laboratory request and result form and measles/ rubella case study form must be filled * accept the informed consent form * positive measles ig m and measles ig g laboratory test exclusion criteria: * rejected the informed consent form

Keywords: measles vaccine children vitamin a
immediate effects of two spinal manipulative techniques

Conditions: Chronic Low-back Pain

Summary: the aim of this study is to investigate the instant effects of direct vertabral manipulation and indirect vertebral manipulation techniques on muscles mechanical properties, pressure-pain threshold and joint range of motion in individuals with chronic low back pain. another purpose of this study was to compare the effects of both treatment methods on the parameters studied.

resolving chronic low back pain is a costly obstacle. there is a wide spectrum of treatment for chronic low back pain, such as exercise training, pain training and spinal manipulation.it is the recommended spinal manipulation in the short and long term in chronic low back pain. clinical spinal manipulation is one of the most preferred methods of reducing pain and disability.

Eligibility criteria:
inclusion criteria: * 18-65 ages * individuals with non-specific chronic low back pain who have continued pain for at least 3 months * according to vas, individuals with pain of at least 3 severity exclusion criteria: * pregnancy situation or suspicion * spinal stenosis * vertebral fracture * cancer * osteoporosis * individuals with bmi over 30 kg/m2 * those with neurological disease that leads to november loss of muscle strength or spasticity-rigidity

Keywords: acute manipulation chronic manipulation low back pain muscles mechanical treshold physiotherapy
electrically guided bachmann's bundle pacing: a lead placement strategy with potential antiarrhythmic benefits

Conditions: Atrial Fibrillation

Summary: despite identification of optimal ventricular pacing sites, which not only avoid dyssynchronous activation but can restore ventricular synchrony, optimal atrial pacing sites have not yet been identified. specialized conduction tracts do not exist in the atria as they do in the ventricle. activating the atria in a manner that preserves or improves interatrial synchrony may provide clinical benefit based on recent data. prior site-selective right atrial septal pacing (ras) pacing studies relied on non-specific fluoroscopic guidance during lead placement. these studies were limited by the lack of an electrogram target and electrical measures of successful atrial resynchronization. the goal of this study is to prospectively evaluate bachmann's bundle lead placement guided by fluoroscopy and electrical markers (an endocardial electrogram target and paced p-wave criteria) and determine its anti-arrhythmic efficacy compared with right atrial appendage (raa) pacing. patients presenting for pacemaker placement with an indication for an atrial lead are randomized to either electrically-guided bb lead placement or raa lead placement and then followed for 15 months.


Eligibility criteria:
inclusion criteria: * subject is \>18 years old * subject is referred for permanent pacemaker implantation with an indication for an atrial lead * subject has either paroxysmal atrial fibrillation or baseline intra-atrial conduction delay (p-wave duration \>120ms on a 12-lead ecg) * subject is expected to remain available for standard-of-care pacemaker follow-up visits and study questionnaires exclusion criteria: * subject has permanent atrial fibrillation or is in atrial fibrillation in the pre-operative area prior to the procedure (inability to assess paced p-wave morphology) * subject has pacemaker implantation prior to planned atrioventricular nodal ablation * subject has resting spontaneous sinus rate \>85 beats-per-minute * subject has left ventricular ejection fraction \<45% * subject is unable or unwilling to complete baseline or follow up quality of life questionnaires * subject is currently enrolled in a potentially confounding trial * subject is pregnant * subject's anticipated life expectancy is less than 1 year
combined effects of low level laser therapy and kabat technique in patients with bell's palsy

Conditions: Bell Palsy

Summary: the objective of this current study is to determine the combined effects of low-level laser therapy (lllt) and the kabat technique on quality of life, synkinetic movements and functional outcome in patients of bell's palsy

bell's palsy is an acute condition which occurs by the damage of 7th cranial nerve along its course at the level which is distal to pons. basically it is an idiopathic facial condition. the yearly incidence of bell's palsy is 15 to 30 per 100,000 people, which affect both sexes equally. this study aims to see combined effects of low level laser therapy and kabat technique in the treatment of bell's palsy. synkinesis, which is described as an involuntary movement in one part of the face produced during voluntary movement in another region of the face, is a problematic bell's palsy sequel. the mechanism behind the formation of synkinesis is unknown. according to the predominant idea, damaged axons regenerate abnormally, innervating facial muscles that weren't originally innervated. the yearly incidence of bell's palsy is 15 to 30 per 100,000 people, which affect both sexes equally. kabat technique is neurorehabilitation technique that uses diagonal and spiral patterns for movement in conjunction with stretch and resistance and other pnf techniques to reinforce neuromuscular recruitment. it mainly concerns the stimulation of these muscles: orbicularis occuli, ztgomaticus, levator labii, nasalis, buccinator, frontalis, corrugator. for all bp patients, including those who are unable to take corticosteroids due to diabetes or hypertension, laser therapy offers a non-invasive, painless means of treatment. however, just a few researches have examined the effectiveness of low- dose laser therapy in bp patients. low level laser therapy has the potential to promote nerve regeneration, reduce inflammation, and accelerate tissue healing in the affected facial nerve. on the other hand, the kabat technique focuses on restoring neuromuscular control and improving muscle function. by combining low level laser therapy and the kabat technique, a synergistic effect may be achieved, maximizing the potential benefits of both interventions. therefore, this study aims to determine the specific parameters and protocols for the combined use of low level laser therapy and the kabat technique in bell's palsy

Eligibility criteria:
inclusion criteria: * age 18-40 * both genders will be included * unilateral facial paralysis/paresis * patients presented within onset of 12 days - 3 weeks (sub-acute bell's palsy) exclusion criteria: * previous surgery of facial reconstruction * traumatic brain injury * any other neurological deficit * congenital deformities * recurrent bell's palsy will be excluded

Keywords: bell's palsy facial disability index kabat technique low level laser therapy sunnybrook facial grading system
classification of heart failure with preserved ejection fraction

Conditions: Heart Failure With Preserved Ejection Fraction; Diastolic Heart Failure

Summary: the purpose of this study is to create a classification system for the heterogenous disorder of heart failure with preserved ejection fraction (hfpef).

patients with hfpef are a heterogeneous group with varying etiology and pathophysiology, which may play a large role in the difficulty in managing these patients and enrolling them in clinical trials. a major advance in the care of patients with hfpef would be a classification system based on etiology, pathophysiology, and/or genetic factors as well as machine learning analyses. the ultimate goal of this study is to demonstrate that it is possible to better classify patients with hfpef based on etiologic, pathophysiologic, and genetic differences between patients. if successful, this study could lead to: (1) novel risk estimation in patients with hfpef and (2) more fruitful clinical trials based on targeting specific subsets of hfpef.

Eligibility criteria:
inclusion criteria: * age \> 21 years * signs or symptoms of congestive heart failure * left ventricular ejection fraction \> 50% exclusion criteria: * severe valvular heart disease * history of cardiac transplantation * prior history of heart failure associated with left ventricular ejection fraction \< 35%

Keywords: heart failure ejection fraction diastolic heart failure diastolic dysfunction ventricular-arterial coupling exercise testing echocardiography tissue doppler imaging arterial tonometry genetics epidemiology
new technologies to help manage adhd

Conditions: Attention Deficit Hyperactivity Disorder

Summary: cluster randomized controlled trial to evaluate the general effectiveness of intervention compared to control on medication continuity as measured by prescriptions written and other more proximal outcomes during the first six months of treatment.

this cluster randomized controlled trial will evaluate the general effectiveness of the intervention (e.g. enhanced myadhdportal.com), compared to control (e.g. treatment as usual standard portal), on medication continuity as measured by prescriptions written and other more proximal outcomes during the first six months of treatment.

Eligibility criteria:
inclusion criteria: * parents of children are eligible to participate if 1. their child receives adhd care at one of the pediatric primary care practices that is partnering to conduct this trial 2. child being registered on myadhdportal.com to initiate child assessment of adhd 3. child age 6-10 years 4. child must not have been previously treated with adhd medication 5. child prescribed adhd medication within 12 months of enrolling in the study exclusion criteria: * unable to read and speak english
study of nimotuzumab in combination with neoadjuvant chemotherapy for cervical cancer

Conditions: Cervical Cancer

Summary: nimotuzumab is a humanized monoclonal antibody against epidermal growth factor receptor (egfr). clinical trials are ongoing globally to evaluate nimotuzumab in different indications. nimotuzumab has been approved to treat squamous cell carcinoma of head and neck (scchn), glioma and nasopharyngeal carcinoma in different countries. the clinical phaseⅱtrial is designed to assess the resection rate and pathological complete response of nimotuzumab plus carboplatin and paclitaxel in patients with cervical cancer.


Eligibility criteria:
inclusion criteria: 1. age:18-70 years 2. histological confirmed cervical squamous cell carcinoma 3. figo stage: ib2-iiib 4. tumor lesions and stages are confirmed by the internal medicine, obstetrics and gynecology inspection, including a pelvic exam and abdominal and pelvic ct,.if necessary, laparoscopy, cystoscopy and pelvic mri examination will be taken. 5. at least one lesions can be measured 6. no previous therapy 7. ecog performance status 0-2 8. life expectancy of more than 6 months 9. normal hematology:haemoglobin≥90g/l,white blood cell(wbc)≥4×109/l absolute neutrophil count≥1.5×109/l,platelet count≥100×109/l, normal renal function: serum creatinine\ 60ml/min；normal liver function:tbil≤1.5 uln, ast and alt≤1.5 uln 10. without lung or heart disease 11. without active infection 12. signed informed consent and submit to the organization of research exclusion criteria: 1. severe systemic or uncontrolled disease, unfit for chemotherapy 2. neuropathy caused by any reason 3. psychiatric disease 4. other malignant tumor 5. bilateral renal pelvis and ureter hydrocephalus who can't be alleviated by ureteral stent or percutaneous nephrostomy, abnormal serum creatinine level 6. infection and severe systemic disease 7. received other anti egfr monoclonal antibody treatment 8. participation in other interventional clinical trials 9. allergic constitution or history of drug allergy 10. pregnant or breast-feeding or refused to take contraceptive method 11. poor compliance
higher vs. lower dose heparin for pci

Conditions: Cardiovascular Diseases; Percutaneous Coronary Intervention

Summary: hd pci is a multicenter, randomized, registry-based, cluster crossover design trial of higher dose versus lower dose heparin in patients undergoing elective percutaneous coronary intervention (pci).

the primary objective of hd pci is to compare the effect of a policy of higher dose heparin (100 u/kg) use to a policy of lower dose heparin (70 u/kg) use on death, myocardial infarction (mi) or target vessel revascularization (tvr) in patients undergoing elective percutaneous coronary intervention (pci).

Eligibility criteria:
inclusion criteria: - patients undergoing elective pci exclusion criteria: * age \<18 years * planned chronic total occlusion pci * non-resident precluding follow up through local registries hospital (cluster) eligibility criteria hospitals will be eligible to participate if they meet the following criteria: * submit pci procedure data to a compatible registry that is able to provide data for the trial * site agrees to manage patients as per the higher or lower dose heparin policy in place during the given crossover period