Kornimate/medical-research-clean huggingface dataset:
relevance of whole-body computed tomography prescription in the emergency department : an identification tool for low risk patients

Conditions: Trauma

Summary: the whole-body scanner (sce) is a powerful examination that guides the management of patients severely traumatized. however, the systematic use of this examination in emergency departments is responsible for a large proportion of normal examinations. in addition to the non-negligible direct cost, the average irradiation of 20 msv would give an adult a 1 in 1000 risk of developing a cancer. the vittel score makes it possible to categorize pre-hospital patients as seriously traumatized to guide the sending of resources and direct them to a center equipped with a suitable technical platform. the use of this score to condition the prescription of the ecs is at the origin of an over-triage important since one out of two patients who validates at least one criterion has no lesion on imaging. the purpose of this research project is to validate a decision support tool to objectively guide the emergency physician in its use of the ecs. at the same time, the economic impact of such a procedure will be analysed.


Eligibility criteria:
inclusion criteria: * any adult patient undergoing an sce as part of a post-traumatic lesion assessment during a stay in the emergency room. * mechanism of injury: road accident or fall. * patient having read and understood the information letter and given his oral consent. exclusion criteria: * neurological impairment defined by a glasgow score of less than 8. * respiratory failure with spo2 \< 90% on oxygen or with the use of ventilatory assistance. * hemodynamic failure with vascular filling greater than 1000 cc or recourse to catecholamines. * acute alcoholism. * taking narcotics. * history of cognitive disorders. * current pregnancy. * suicidal patient. * trauma related to a brawl * penetrating trauma. * hemophilia. * known thrombocytopenia at the time of inclusion. * heart, lung, liver or kidney transplant patient. * person deprived of liberty by an administrative or judicial decision or person placed under legal safeguard / sub-tutorship or curatorship.
effects of dpp4 inhibitor versus sglt2 inhibitor

Conditions: Diabetes Mellitus, Type 2; Ischemic Heart Disease

Summary: type 2 diabetes mellitus (type 2 dm) is an important disease with increasing prevalence worldwide. more than 60% of diabetes patients die of cvd. diabetes is associated with 2-to 4- fold increase in the risk of coronary artery disease (cad). diabetes patients with stable ischemic heart disease may have more prevalent of asymptomatic ischemia or silent ischemia due to autonomic neuropathy. therefore, detection of total myocardial ischemia including both symptomatic and silent ischemia using ambulatory electrocardiogram monitoring may provide better accuracy in ischemic burden and prognosis in diabetes patients. ddp-4 inhibitors have favorable effects on atherosclerotic risk factors beyond glycemic control. furthermore, dpp-4 inhibitors may have favorable effects on ischemic preconditioning in patients with cad. for this study we aim to compare the effects of between vildagliptin and dapagliflozin on ischemic burden defined by total ischemic time, markers of autonomic function, biomarkers of myocardial injury and biomarkers of inflammation.


Eligibility criteria:
inclusion criteria: 1. adult patients (age \> 21), male or non-child bearing potential female 2. inadequately controlled type 2 diabetes with at least half maximum dose of metformin (hba1c \> 6.5 and \< 9.0%) 3. stable documented cad defined as the followings: 1. stable angina with \> 70% stenosis of at least one major epicardial artery from coronary angiogram (cag) or coronary cta 2. post myocardial infarction (\> 30 days) exclusion criteria: 1. significant renal function (egfr \< 30ml/min) 2. significant hepatic impairment or alt/ast elevations beyond x2 upper normal limit or known hepatic failure 3. planned coronary intervention or planed surgical intervention (pci or cabg) 4. recent (\<30 day) acute coronary syndrome (acs) 5. hypersensitivity to either of the study drug components 6. history of lactic acidosis 7. type 1 diabetes 8. current hba1c \>9% 9. current insulin treatment 10. active treatment with glp-1 or other dpp4i medication 11. inability to comply with study protocol 12. active malignancy other than basal cell carcinoma 13. clinically advanced congestive heart failure - nyha iii-iv 14. severe left ventricular dysfunction (lvef\<25%) 15. recent heart failure decompensation (\<3 months) 16. chronic inflammation (i.e. inflammatory bowel disease, lupus, inflammatory arthritis, rheumatoid arthritis) or chronic infection (i.e. chronic diabetic foot infection) 17. pregnancy, lactation or child-bearing potential
cardiac speckle tracking myocardial strain balance

Conditions: Pulmonary Hypertension; Echocardiography

Summary: the investigators intend to evaluate the function of left heart and right heart and the motion balance between four chambers of the heart by speckle tracking technique during the follow-up of patients with pulmonary hypertension, and explore the relationship between the balance and prognosis of patients.

pulmonary hypertension is a fatal disease with progressive progressive vascular resistance that leads to the loss of right heart function. right heart failure is the cause of death in most patients with end-stage pulmonary hypertension, and right heart function is also an important factor in determining the prognosis of patients. echocardiography speckle tracking technology is a noninvasive technique for evaluating global and local cardiac function by tracking myocardial ultrasonic spots through computer image analysis technology and quantifying myocardial deformation. the investigators intend to evaluate the function of left heart and right heart and the motion balance between four chambers of the heart by speckle tracking technique during the follow-up of patients with pulmonary hypertension, and explore the relationship between the balance and prognosis of patients.

Eligibility criteria:
inclusion criteria: diagnosed with pulmonary hypertension by right cardiac catheterization the patient is between 18-80 years of age the date of diagnosis was from 2007 to 2017 exclusion criteria: cardiomyopathy severe complications pregnancy atrial fibrillation, or other irregular heart rhythm poor ultrasonic image quality
hyponatremia in the prevention of hospitalized patients falls

Conditions: Hyponatremia; Accidental Falls

Summary: cross ecological quasi-experimental study to assess effectiveness of early intervention in the diagnosis and treatment of hyponatremia in the prevention of hospitalized patients´ falls.

effectiveness of early intervention in the diagnosis and treatment of hyponatremia in the prevention of hospitalized patients´ falls. aims: 1. to assess the effectiveness of corrective activity of hyponatremia in falls reducing incidence. 2. to assess the cost-effectiveness ratio of the two proposed strategies: conventional treatment versus early intervention. cross ecological quasi-experimental study. the project will take place in gregorio marañón hospital (madrid, spain) in the following inpatient adult units: neurology, rehabilitation 1, geriatrics, internal medicine (group a), cardiology, rehabilitation 2, gastroenterology, neurosurgery and oncology (group b). the estimated sample size for a confidence level of 95% (α = 0.05) and power of 90% (β = 0.010), taking into account a decrease in the incidence of falls of 20% restocking losses, is 124 patients per group (ie, the 124 patients receiving regular performance \*\* and 124 patients receiving the experimental intervention \*, if necessary, by participant unit). data collection: in each of the study participants units both interventions will be held. first the participants units have been randomized in two groups (group a: neurology, rehabilitation 1, geriatrics, internal medicine; group b: cardiology, rehabilitation 2, gastroenterology, neurosurgery and oncology). all patients hospitalized in these units will be potentially included. first of all, collaborators will give them an informed consent to ask for their participation. the interventions are: * experimental intervention: early diagnosis, treatment of hyponatremia until resolution and valuation according to the dynamic gait index test. duration: 6 months * habitual action: the usual pattern of work will be performed in all patients who enter. duration: 6 months.

Eligibility criteria:
inclusion criteria: * age \>65 years * admitted to a participating study unit * wish to participate in the study and signature of informed consent. exclusion criteria: * transfer of the patient to a unit not included in the study * deterioration of the patient's condition to severe or extremely painful

Keywords: accidental falls hyponatremia elderly risk factors nurse
impact of an alarm management protocol on noise pollution and patient safety in intensive care units

Conditions: Intensive Care Unit

Summary: resuscitation patients are monitored for various physiological parameters. when these parameters exceed abnormal thresholds, an audible alarm is triggered. given the complexity of physiological situations and the number of monitored parameters, the number of alarms within an intensive care unit is significant. in the literature, the number ranges from 100 to 350 alarms per patient per day. among these alarms, 74 to 99% are deemed irrelevant as they provide false or insignificant information. this study will enable to assess the efficacy of a restrictive protocol for managing alarms as a means of rationalizing their use.

the large volume of unnecessary alarms has multiple negative repercussions. firstly, the excessively loud sound environment present in most resuscitation services causes stress and discomfort for both patients and caregivers. additionally, nurses become desensitised and less responsive when the number of alarms is high, particularly if many of them are ultimately pointless. finally, multiple interruptions of tasks associated with alarms that require responses are sources of errors in the execution of care and medication preparation. these interruptions contribute to a phenomenon known as "alarm fatigue", which many authorsand health authorities consider a threat to patient safety.the intensive care unit of the saint-etienne university hospital has had a long-standing interest in this topic, and has a computerized data collection tool that permits exhaustive analysis of all alarm signals originating from each resuscitation bed. this study will enable to assess the efficacy of a restrictive protocol for managing alarms as a means of rationalizing their use.

Eligibility criteria:
inclusion criteria: * patient aged ≥ 18 years * patient admitted to the intensive care unit of the st-etienne university hospital * patient affiliated or entitled to a social security system * patient having received informed information about the study and having co-signed, with the investigator, a consent to participate in the study or, for patients who are unable to consent due to health condition, a trusted person/family member who has been informed about the study and has who has co-signed, with the investigator, a consent to participate exclusion criteria: * pregnant and nursing women * persons of legal age under guardianship

Keywords: alarm fatigue nursing staff resuscitation patients restrictive alarm strategy
comparison of upper extremity function, physical activity levels and peripheral muscle strength, fear of movement, balance, activities of daily living and quality of life in patients with pacemakers according to pacemaker type

Conditions: Pacemaker; Implantable Cardioverter Defibrillator; Cardiac Resynchronization Therapy

Summary: while research and clinical practice have demonstrated the objective benefits of pacemaker use on mortality, morbidity, and quality of life, some patients do not experience the expected level of improvement following device implantation. the purpose of this research was to determine the effects of device implantation on daily living activities, upper extremity functions, peripheral muscle strength, balance problems, fear of movement and quality of life.


Eligibility criteria:
inclusion criteria: * at least 3 months have passed since pacemaker implantation and there are no complications in the last pacemaker control, * being in nyha class i-ii-iii, * patients with no coordination problems, * volunteering to participate in the research exclusion criteria: * patients with a history of shoulder pathologies prior to pacemaker implantation that may restrict movement of the upper limb (conditions such as severe pain around the shoulder, edema or shoulder dislocation that may restrict upper limb movement), * patients with a history of shoulder surgery (limitation in range of motion), * patients who have had a cerebrovascular event resulting in mastectomy or arm involvement on the affected side, * patients with decompensated heart failure, * patients with a history of icd inappropriate shock, * those with acute myocardial infarction, * patients with malignancy on active treatment, patients with collagen tissue disease receiving systemic steroids, * chronic kidney disease patients on dialysis with unstable volume load
addiction risk: mindset induction effect on brief intervention

Conditions: Alcohol Drinking in College

Summary: brief interventions (bi) based on motivational interviewing are effective to reduce alcohol use. in this study the investigators test the hypothesis that that an open mindset increases the positive effects of bi. university students take part in a voluntary screened for risky alcohol use. all students with risky alcohol use are eligible to the study and all receive the who's assist-linked bi. participants receive a brief mindset induction prior to receiving bi. they are are randomly assigned to either the induction of an open or a closed mindset according to the mindset theory of action phases (gollwitzer \& keller (2016). mindset theory. in: v. zeigler-hill, t.k. shackelford (eds.), encyclopedia of personality and individual differences. new york: springer). the investigators measure the change in alcohol-related risk perception, treatment motivation and real alcohol drinking after the brief intervention in relation to the mindset induced before receiving the intervention.


Eligibility criteria:
inclusion criteria: * student status at university of konstanz * risky alcohol use in past 12 months exclusion criteria: * acute psychosis, acute suicidality, illiteracy
liposomal bupivacaine (exparel ® ) plus 0.5% bupivacaine hcl versus 0.5% bupivacaine hcl for interscalene nerve block (isb) for patients undergoing total shoulder arthroplasty(tsa)

Conditions: Shoulder Pain

Summary: this is a phase iv , randomized, single-blind, single-center study comparing patient related outcomes such as postoperative pain and opioid usage for patients who receive isb 's containing liposomal bupivacaine (exparel®) plus 0.5% bupivacaine hcl versus 0.5% bupivacaine hcl undergoing total shoulder arthroplasty. the objective of this study is to compare opioid utilization and pain management of patients who receive exparel in an isb vs standard 0.5% bupivacaine hcl during the initial 72 --- hour post --- operative period. additionally, to understand the duration of block after addition of exparel® to bupivacaine in an interscalene block after tsa.


Eligibility criteria:
inclusion criteria: * patients undergoing total shoulder arthroplasty; * patients who consent to be randomized. exclusion criteria: * patients younger than 18 and older than 75; * patients with a history of chronic pain that have used opioids for pain management for 3 months or longer; * patients who are allergic to oxycodone; * patients who are unable to speak english; * patients with diagnosed or self---reported cognitive dysfunction; * patients with a history of neurologic disorder that can interfere with pain sensation; * patients with a history of drug or recorded alcohol abuse; * patients who are unable to understand or follow instructions; * patients with severe liver disease, renal insufficiency, congestive heart failure, and/or significant heart disease; * patients with an allergy or contraindication to any of the medications used in the study, or patients with a contraindication to any study procedures; * patients with bmi over 40; * any patient that the investigators feel cannot comply with all study related procedures; * nyu langone health students, residents, faculty or staff members

Keywords: total shoulder arthroplasty (tsa) interscalene nerve block (isb)
effect of intake of glycin max (l.) merr. peel extract on body fat and body weight

Conditions: Obesity

Summary: the investigators performed a 8-week, randomized, double-blind, placebo-controlled human trial to evaluate the efficacy and safety of glycin max (l.) merr. peel extract on decrement of body fat. the investigators measured decrement of body fat parameters , including body fat mass, percent body fat, weight and bmi(body mass index), and monitored their blood pressure.


Eligibility criteria:
inclusion criteria: * males and females 19-65 years old * bmi(body mass index) ≥ 25 kg/m\^2 or wc(waist circumference) ≥ 90(men), wc ≥ 85(women) * able to give informed consent exclusion criteria: * significant variation in weight(more 10%) in the past 3 months * allergic or hypersensitive to any of the ingredients in the test products * history of reaction to any of the test products or of gastrointestinal diseases such as crohn's disease or gastrointestinal surgery * history of alcohol or substance abuse * participation in any other clinical trials within past 2 months * laboratory test, medical or psychological conditions deemed by the investigators to interfere with successful participation in the study * pregnant or lactating women etc.
protein nutrition for muscle hypertrophy in older adults

Conditions: Healthy Elderly Muscle; Anabolically Resistant Elderly Muscle

Summary: the primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar fsr with protein feeding in the elderly.

the primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar fsr with protein feeding in the elderly

Eligibility criteria:
inclusion criteria: * must habitually complete a minimum of 5000 steps per day * having obtained informed consent * non-obese * non-smoker exclusion criteria: * aged \>80 years * inability to comply with study procedures * currently participating or having participated in another infusion trial during last 12 months * any acute or chronic llness * history of neuromuscular problems * medications known to affect protein metabolism * individuals who complete fewer than 5000 steps per day * individuals who have metal implants
a study on the use of tanakan® for recovery of neurological impairment following ischaemic stroke

Conditions: Stroke, Acute; Neurological Impairment

Summary: the purpose of this study is to evaluate the effectiveness of tanakan® 240mg in association with acetylsalicylic acid (325mg/day) in the recovery of neurological impairment following ischemic stroke.


Eligibility criteria:
inclusion criteria: * patient having had a single infarct in the carotid artery territory 3 to 8 days before inclusion * patient with a moderately severe or severe disability (modified rankin score 4 or 5) * patient having a quick's test (for inr) and appt (activated partial prothrombin time) test in the normal values of the laboratory exclusion criteria: * patients having had an ischemic stroke (ct confirmed) less than 3 days and more than 8 days prior * patient with known pre-existent cerebral infarction * infarct damaged area bigger than 1/3 hemisphere * patient having a score below the cut-off point at frenchay aphasia short test
fertility preservation in cases of klinefelter syndrome.

Conditions: Klinefelter Syndrome

Summary: klinefelter syndrome (ks) is the most common sex chromosomal abnormalities (1/600 newborn males), and is characterized by a hypergonadism hypogonadism. until few years ago, mostly non-mosaic ks was considered as a model of a complete male infertility although few ks (4-8%) have an oligospermia. recent studies in adult with non-mosaic ks reported the possibility of sperm retrieval by testicular biopsy (tese) in around 50% cases and more than some pregnancies have been obtained after tese with intracytoplasmic sperm injection (icsi). since 1997, more than one hundred births are described. as some studies shown a decrease of successful sperm retrieval with the increasing of age, we plan to compare the potential of sperm retrieval between two groups "adult" (23-55 years) and "young" after the onset of puberty (15-22 years). the study will be performed by searching spermatozoa on two seminal analyses spaced out 3 months followed by a testicular biopsy if the azoospermia is confirmed on semen analyses.


Eligibility criteria:
inclusion criteria: * klinefelter syndrome with 47,xxy non-mosaic * androgenotherapy stopped since more than 6 months exclusion criteria: * antecedent of radiotherapy or chemotherapy * psychological trouble * treatment interfering with spermatogenesis * androgenotherapy non stopped

Keywords: klinefelter syndrome azoospermia seminal analyses testicular biopsy
serotonin role on brain circuits involved in food avoidance in anorexia nervosa

Conditions: Anorexia Nervosa

Summary: serotoninergic activity in brain structures involved in food control and avoidance, such as the basal ganglia, is poorly understood in anorexia nervosa.

a simultaneous positron emission tomography (pet)- functional magnetic resonance imaging (fmri) approach and testing of food preferences and choices will provide further insight into the link between potential abnormalities in serotoninergic transmission and the specific food restriction disorder for anorexia nervosa. these data can pave the way for new therapeutic avenues.

Eligibility criteria:
common criteria for inclusion : * signature of written consent * subject affiliated or entitled to a social security scheme inclusion criteria: patients with restrictive anorexia nervosa (30 subjects). * anorexia nervosa common features : fear of weight gain, dysmorphophobia, bmi \< 17.5 kg/ m², amenorrhea * absence of food compulsions and purges * subgroup 1 (15 subjects) : stai y2 anxiety score \> 61 * subgroup 2 (15 subjects) : stai y2 anxiety score \< 51 inclusion criteria - female control subjects (15 subjects) * bmi between 18.5 and 25 kg/ m² * absence of a psychological profile of eating disorder or other psychiatric disorders. exclusion criteria: * subjects with an oral contraception and breastfeeding woman * subject with heart failure * subject treated during the last three months with neuroleptics, and antiparkinsonian drugs, monoamine oxidase (mao)-a or monoamine oxidase (moa)-b inhibitors, tricyclic antidepressants, 5ht reuptake inhibitors, thymo regulators (lithium), antiepileptic dugs, codeine derivatives, morphinics, tramadol-containing products (topalgic, ...),dopaminergic drugs. * subjects with suspected pregnancy; test β human chorionic gonadotropin (hcg) positive prior to examination. * subjects for whom mri is contraindicated (pacemaker, intracerebral clips, prosthesis made of ferromagnetic material or claustrophobia). * subjects unable to sign written consent for participation in the study. * subject deprived of liberty by a judicial or administrative decision

Keywords: anorexia nervosa serotonin pet-mri eating disorders