Kornimate/medical-research-clean huggingface dataset:
comparative clinical effects of salvadora persica oral rinse and a phenolic commercial mouth wash on human oral health

Conditions: Plaque, Dental

Summary: abstract: objective: to compare the clinical effects of salvadora persica (miswak) oral rinse and commercial listerein mouth wash on oral health of socially deprived madrasa girls. methods: girls aged 18-22 years living permanently in a madrasa of multan city will be recruited. sample size and trial duration will be determined using the american dental association guidelines. participants will be randomized into two interventional groups; a and b and will be either provided with salvadora persica oral rinse and commercial listerein mouth wash respectively. pre, mid and post-intervention examinations will be executed by a blind and calibrated examiner using turesky quigley hein plaque and loe and silness gingival indices. statistical analysis will include descriptive statistics and two sample independent t-tests. the p-value of \<0.05 will be considered significant at 95 % confidence level. key words: dental plaque, gingivitis, miswak, mouthwash

comparative clinical effects of salvadora persica (miswak) oral rinse and commercial listerein mouth wash will be studied on the oral health of socially deprived madrasa girls. girls aged 18-22 years living permanently in a madrasa of multan city will be recruited. sample size and trial duration will be determined using the american dental association guidelines. participants will be randomized into two interventional groups; a and b and were either provided with salvadora persica oral rinse and commercial listerein mouth wash respectively. pre, mid and post-intervention examinations will be executed by a blind and calibrated examiner using turesky quigley hein plaque and loe and silness gingival indices. statistical analysis will include descriptive statistics and two sample independent t-tests. the p-value of \<0.05 will be considered significant at 95 % confidence level.

Eligibility criteria:
exclusion criteria: * participants/girls with any medical or dental disease, * participants/girls with any dental prosthesis, * those taken antibiotics in last 6 months, * those received any periodontal therapy in last 3 months inclusion criteria: \*participants with at least 10 sites of chronic mild gingivitis with bleeding on probing but not having periodontal pockets of greater than 3mm

Keywords: dental plaque gingivitis miswak mouthwash
molecular and epidemiological risk factors in the development of gastric cancer

Conditions: Gastric Cancer

Summary: this protocol is a single-institution feasibility study to identify the molecular and epidemiological risk factors in the development of gastric cancer in high-risk predominantly hispanic south texas population. the study is broken down into two main parts: 1) to identify molecular differences in gastric adenocarcinoma (gac) between non-hispanics and hispanics, stratified by age, and in benign, pre-malignant, and malignant gastric lesions; and 2) to identify environmental and clinicopathological factors in hispanics associated with specific molecular changes linked to the development of gac.

the first part of the study will be accomplished by performing molecular testing on formalin-fixed paraffin-embedded (ffpe) tissues on retrospectively identified patients with gac. germline testing will be done on both retrospectively and prospectively identified cohort of patients with diagnosis of gac. the second part of the study will be accomplished via survey administration on retrospectively and prospectively identified patients with diagnosis of gac and to test helicobacter pylori (h. pylori) and epstein-barr virus (ebv) infection status, which are known risk factors for the development of gac, on their ffpe gastric specimen. the data from part 1 and part 2 will be analyzed and correlated. the overall goal of the study is to identify molecular markers and environmental risk factors in gac unique to hispanics relative to non-hispanics in south texas, and to define molecular alterations in pre-malignant gastric lesions associated with the development of gac. the long-term goal is to improve racial disparities by defining prognostic and therapeutic molecular markers and environmental risk factors in hispanics and ultimately for all patients with gac. identification of high-risk molecular markers and environmental factors in the development of gac will help future deployment of improved prevention and surveillance modalities.

Eligibility criteria:
inclusion criteria: * aged 18 years or older * patient with histologically confirmed diagnosis of gastric adenocarcinoma * able to understand english or spanish (only for the prospective cohort) * gej adenocarcinoma type ii (within 1 cm above and 2 cm below the gej) and type iii (2-5 cm below the gej) * hyperplastic polyps exclusion criteria: * clinically and genetically confirmed diagnosis of well-established hereditary cancer syndrome * gastroesophageal junction (gej) adenocarcinoma type i (1-5 cm above the gej) as they are treated as esophageal cancer * other benign or malignant histology types (i.e. leiomyoma, gastrointestinal stroma tumors, fundic gland polyps, etc.)
translating healthy lifestyle interventions for cancer survivors

Conditions: Diabetes Mellitus, Non-Insulin-Dependent; Breast Cancer; Endometrial Cancer

Summary: investigators proposed to refine and test the feasibility and acceptability of a 4-month multi-modal lifestyle intervention in african american female breast or endometrial cancer survivors diagnosed with type 2 diabetes.

recent systematic reviews and meta-analyses of cohort studies show that physical activity can reduce mortality and morbidity in diabetes and obesity-related cancers. yet, there have been few efforts to promote physical activity within the context of female cancer survivorship, particularly among women with diabetes. in response, investigators proposed to refine and test the feasibility and acceptability of a 4-month multi-modal lifestyle intervention in african americans (aa) with diabetes and who are breast or endometrial cancer survivors. this web-based, lifestyle intervention, coupled with coaching calls and in-person exercise sessions, may be an effective way to promote physical activity and healthy survivorship. the primary goal is for participants to participate in 30 minutes of moderate-to-vigorous physical activity five times a week. the investigators' aims : i) refine a theory-driven healthy lifestyle intervention, that is delivered via computer technologies and periodic in-person group exercise sessions with appropriate content, literacy demand and graphics, ii) assess the preliminary effects of the intervention on the primary outcome of level of moderate to vigorous physical activity (mvpa), as measured by accelerometry; weight, glycosylated hemaglobin and evaluate the effect of eating behaviors, wellbeing/functioning (quality of life, depressive symptoms, self-efficacy), compliance/adherence to protocol and acceptability on response to the intervention.

Eligibility criteria:
inclusion criteria: * african american women, ages 30 * no evidence of pregnancy, as evidenced by negative urine pregnancy test. * diagnosed with type 2 diabetes by their provider * diagnosed with stage i-iii breast or endometrial cancer * completed treatment for breast or endometrial cancer at least 4 months and no more 5 years ago english-speaking * agree to participate in all aspects of the semi-structured interview (aim 1) * agree to participate in all aspects of the feasibility study, including group sessions (aim 2) * access to the internet via phone or computer * access to a working phone for personal use exclusion criteria: * non-english speaking * recent epilepsy, cardiac event or stroke in last 6 months,special nutritional needs (e.g. current evidence of malignancy; hiv) * history of epilepsy, cardiac event or stroke within the last year * known diagnosis of hiv * known new malignancy * less than 4 months or more than 2 years post treatment of stage i-iii breast or endometrial cancer. * no diagnosis of type 2 diabetes * no self-report of african american race/ethnicity * no access to a phone for personal use * no access to the internet via computer or mobile phone

Keywords: cancer breast cancer endometrial cancer, type 2 diabetes
nutrition in people with a lower limb amputation

Conditions: Diet, Food, and Nutrition; Nutrition Disorders; Amputation

Summary: the goal of this prospective longitudinal observational cohort study is to determine the nutritional intake, nutritional status, and physical activity level in people who have undergone a major dysvascular lower limb amputation (lla) at different moments post-lla (during hospital admission several days post-lla, and at 5 weeks, 6 months, and 9 months post-lla). the main questions this study aims to answer are: * what is the nutritional intake, nutritional status, and physical activity level at different moments post-lla? * what is the association between nutritional intake and physical activity level, and nutritional status? * what is the association between nutritional intake, nutritional status and physical activity level and clinical outcomes (mortality, wound healing, quality of life, physical functioning)?

people requiring an lla are at high risk for adverse clinical outcomes. undernutrition and low physical activity level may affect clinical outcomes negatively. however, little is known about the nutritional intake, nutritional status and physical activity level in the lla population, and their association with clinical outcomes.

Eligibility criteria:
inclusion criteria: * undergoing or recently (i.e., within the last seven weeks) having undergone a major dysvascular lower limb amputation (i.e., syme amputation or more proximal level) * 18 years or older * able to collaborate exclusion criteria: * requiring re-amputation * severe malabsorption disease

Keywords: nutrition malnutrition physical activity amputation outcomes
coenzyme q10 and clomiphene citrate (cc) for ovulation induction in polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome

Summary: objective of the study was to evaluate the effect of combination of oral coenzyme q10 (coq10), with clomiphene citrate (cc) for ovulation induction in cc-resistant polycystic ovary syndrome (pcos).in a prospective controlled randomized trial performed in a university hospital and private practice setting. one hundred ten infertile women with pcos resistant to cc were randomized to either combined cc/coq10 (51 patients, 82 cycles) or cc 150 mg/day alone (50 patients, 71 cycles) for ovulation induction in patients with cc-resistant pcos. main outcome measures: number of follicles, serum e2, serum p, endometrial thickness, pregnancy rate (pr) and miscarriage rate.

no more details

Eligibility criteria:
inclusion criteria: * diagnosis of pcos based on the revised 2003 consensus on diagnostic criteria and long-term health risks related to pcos (2003). * all women were previously treated with 100 mg of cc daily for 5 days per cycle, for two to three cycles with persistent anovulation or ovulate with very thin endometrium \<5 mm at the time of hcg administration exclusion criteria: * patients with hyperprolactinaemia, * hypercorticism and * thyroid dysfunction. * patients receiving medications as cholesterol lowering drugs, as statins, beta-blockers, and tricyclic antidepressants

Keywords: pcos coenzymeq10 clomiphene citrate
long-term follow-up study of unilateral microtia patients implanted with aur-201

Conditions: Microtia

Summary: long-term follow-up of unilateral microtia patients implanted with aur-201.

long-term follow-up study of unilateral microtia patients who participated in study aur-201-05 and had the aur-201 implant in place at the final visit (24 weeks post-implantation).

Eligibility criteria:
inclusion criteria: 1. participated in study aur-201-05 and had the aur-201 implant (auricle\* or auricle and wedge) in place at the final study visit of study aur-201-05 (24 weeks after the first implantation surgery). \*if the principal investigator (pi) opted not to implant the wedge component beneath the auricle component and the subject has only the auricle in place at the final study visit of study aur-201-05, the subject will be considered eligible under this inclusion criterion; 2. subject or guardian signed the informed consent form (icf). exclusion criteria: 1. any condition which, in the opinion of the pi, places the subject at unacceptable risk if he/she were to participate in the study.
partial posterior hyaloidectomy in macular surgery

Conditions: Retinal Break; Retinal Detachment

Summary: to evaluate the effect of partial posterior hyaloidectomy on preventing iatrogenic retinal breaks related to induction of a posterior vitreous detachment

the induction of a posterior vitreous detachment (ipvd) during vitrectomy have been suggested as one of the etiologies of iatrogenic retinal break related to vitrectomy.the iatrogenic retinal breaks related to ipvd usually develop near or anterior to the equatorial region. thus, the investigators hypothesized that this complication could be prevented by restricting the extent of ipvd, and planned a modified procedure of vitrectomy in which the extent of ipvd and removal of vitreous cortex was restricted to about slightly beyond the margin of temporal major vascular arcade. the investigators have termed this procedure, partial posterior hyaloidectomy. unlike rrd or proliferative diabetic retinopathy, lesions are localized within the major vascular arcade in macular disorders so that macular disorders could be an eligible indication for this procedure.

Eligibility criteria:
inclusion criteria: * cases of idiopathic erm or idiopathic mh without evidence of pvd preoperatively exclusion criteria: * history of previous intraocular surgery

Keywords: prevention retinal break vitrectomy partial posterior hyaloidectomy
cardiac metabolic remodeling after pulmonary vasodilator therapy in pulmonary arterial hypertension: a pilot study

Conditions: Pulmonary Arterial Hypertension; Right-Sided Heart Failure

Summary: pulmonary arterial hypertension(pah) is associated with the development of right heart failure. in the setting of heart failure, the heart shifts to increasing dependence on glucose metabolism. in this study, the investigators will perform cardiac positron emission tomography/magnetic resonance imaging (pet/mri) scans to measure glucose metabolism in the heart before and after initiation of pulmonary vasodilator therapy for pulmonary arterial hypertension.

pulmonary arterial hypertension is associated with the development of right heart failure. in the setting of heart failure, the heart shifts to increasing dependence on glucose metabolism. in this study, the investigators will perform cardiac positron emission tomography/magnetic resonance imaging (pet/mri) scans to measure glucose metabolism in the heart before and after initiation of pulmonary vasodilator therapy for pulmonary arterial hypertension. by utilizing a rest-exercise protocol and continuous pet imaging acquisition, we can capture real-time changes in glucose uptake in the heart in response to acute exercise. by coupling these measures of dynamic glucose utilization with mri-based cardiac function, we will determine cardiac metabolic efficiency.

Eligibility criteria:
inclusion criteria: * world health organization(who) group pah secondary into idiopathic pulmonary arterial hypertension(ipah) or connective tissue disease associated pulmonary arterial hypertension (ctdpah) * new york heart association (nyha) classification i - iii heart failure * vasodilator therapy naive * able to provide informed consent exclusion criteria: * metabolic disorders such as uncontrolled diabetes (a1c \> 8%) that may interfere with fdg uptake * baseline 6-minute walk distance (6mwd) \< 400 feet or nyha class iv heart failure * musculoskeletal abnormalities that would prevent exercise * contraindications to mri

Keywords: pulmonary arterial hypertension right-sided heart failure metabolism pet/mri
using mobile health to respond early to acute exacerbations of copd in hiv

Conditions: COPD; COPD Exacerbation

Summary: investigators propose to develop methods to improve early identification of acute exacerbations of copd (aecopd) among hiv-infected individuals. investigators hypothesize that earlier identification of acute exacerbations through in-home monitoring of respiratory symptoms, lung function and medication usage will allow appropriate intervention to reduce the morbidity associated with aecopd. therefore, the investigators propose using innovative mobile health (mhealth) applications to respond early to acute exacerbations of copd in hiv (mreach). copd is a co-morbidity of hiv with growing recognition, but remains greatly under-recognized among hiv-infected persons. in this application, among hiv-infected individuals with spirometry-confirmed copd, investigators will conduct a pilot randomized trial of mhealth monitoring compared to usual care to reduce the symptom and clinical burden of aecopd.


Eligibility criteria:
inclusion criteria: * hiv infected * has an established longitudinal care provider in baltimore, md * confirmed copd defined as post-bronchodilator fev1/fvc\<0.70 * stable residence for duration of 6 month intervention exclusion criteria: * age \< 18 years * unable/unwilling to provide informed consent * failure to present to randomization visit

Keywords: hiv mobile health spirometry
facial aesthetic analysis model based on clinical cohort phenotype to explore 45° facial profile.

Conditions: Malocclusion, Angle Class II; Malocclusion, Angle Class III

Summary: facial aesthetics has always been a complex and subjective concept. the overall facial harmony, along with lip protrusion, which is often a focus for orthodontists, requires evaluation from multiple perspectives. the viewing angle also influences the assessment of facial aesthetics, particularly the judgment of lip protrusion. this study aims to explore the differences in facial fixation patterns and aesthetic evaluations among different populations at specific viewing angles by using digital models to simulate various perspectives.

in the analysis of facial aesthetics, the 45° profile has a unique advantage in evaluating lip protrusion, zygomatic fullness, and contour curve. compared to the frontal view, this angle provides a more three-dimensional and deeper perspective. in a previous study, the research group found that the shape of the midface area at 45° influences the evaluation of lip protrusion. in this study, a digital model was used to simulate the protrusion of different midface areas in order to explore the differences in facial fixation patterns and aesthetic evaluations among various individuals at 45°. based on data from individuals who showed significant improvement in frontal and profile beauty before and after clinical treatment, the study added an evaluation of beauty and lip position from the 45° profile. this aims to provide a reference for the subsequent establishment of a 45° profile analysis.

Eligibility criteria:
inclusion criteria: orthodontist inclusion criteria: ① with dental doctor qualification certificate; ② at least 2 years of professional training in orthodontics. inclusion criteria for orthodontic patients: ① receiving orthodontic treatment for more than 1 year; ② volunteer to participate in the study; ③ native language is chinese, can understand the prompt language and normal communication. general adult inclusion criteria: ① have not experienced orthodontic treatment or have no need for orthodontic treatment; ② do not engage in stomatology industry, have not studied stomatology specialty; ③ native language is chinese, can understand the prompt language and normal communication. exclusion criteria: ① have visual impairment (such as color blindness, high myopia); ②have psychological problems (such as autism, schizophrenia); ③ recent use of alcohol, or long-term fatigue, anxiety; current use of any medication that may affect cognitive ability; ⑤ use mascara, contact lenses or small frame height glasses

Keywords: midface eye tracking aesthetic evaluation perception morphology
patients engaged in prevention: enhancing outreach to increase patient engagement in diabetes prevention

Conditions: Preventive Health Services; Health Communication

Summary: this study examines whether a health message that includes a self-affirmation intervention (where people reflect on values that are important to them) increases acceptance of the message and encourages people to take steps to prevent diabetes, as compared to a health message without the self affirmation intervention.

background: despite availability of evidence-based programs for diabetes prevention, few strategies exist to promote patients' interest in them. strategies should be developed for racial/ethnic minority women with a history of gestational diabetes (gdm), who face exceptionally high risk for chronic diabetes. we previously found that a theory-based outreach message containing a streamlined values affirmation-two sentences prompting individuals to reflect on core personal values-increased women's likelihood of demonstrating interest in a preventive program. extending this work, this pilot trial tests whether the values affirmation outreach message is as acceptable as (non-inferior to) a standard outreach message among african-american and latina women. methods: two-arm, parallel-group, randomized trial among english- and spanish-speaking minority women with prior gdm and overweight/obesity in a healthcare system. within an online survey, participants are randomized to read an outreach message promoting an existing preventive program. the message contains either a values affirmation (intervention condition) or no affirmation (control condition).

Eligibility criteria:
inclusion criteria: * history of gestational diabetes * body mass index ≥25 kg/m2 * english or spanish language exclusion criteria: * current diabetes * current pregnancy

Keywords: diabetes, gestational diabetes mellitus
first in human study of torl-2-307-adc in participants with advanced cancer

Conditions: Advanced Solid Tumor; Gastric Cancer; Pancreas Cancer; Gastroesophageal Junction Adenocarcinoma

Summary: this first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of torl-2-307-adc in patients with advanced cancer


Eligibility criteria:
inclusion criteria: * advanced solid tumor * measurable disease, per recist v1.1 * eastern cooperative oncology group (ecog) performance status 0-1 * adequate organ function exclusion criteria: * has not recovered \[recovery is defined as nci ctcae, version 5.0, grade ≤1\] from the acute toxicities of previous therapy, except treatment-related alopecia or laboratory abnormalities otherwise meeting eligibility requirements * received prior chemotherapeutic, investigational, or other therapies for the treatment of cancer within 14 days with small molecule and within 28 days with biologic before the first dose of torl-2-307-adc * progressive or symptomatic brain metastases * serious, uncontrolled medical disorder, nonmalignant systemic disease, or active, uncontrolled infection * history of significant cardiac disease * history of myelodysplastic syndrome (mds) or aml * history of another cancer within 3 years before day 1 of study treatment, with the exception of basal or squamous cell carcinoma of the skin that has been definitively treated. a history of other malignancies with a low risk of recurrence, including appropriately treated ductal carcinoma in situ (dcis) of the breast and prostate cancer with a gleason score less than or equal to 6, are also not excluded * if female, is pregnant or breastfeeding

Keywords: claudin18.2