Kornimate/medical-research-clean huggingface dataset:
assessing sedentary behaviour in adults with type 2 diabetes - a randomized controlled trial

Conditions: Sedentary Behavior; Diabetes Mellitus, Type 2; Adult ALL

Summary: the purpose of this health behaviour change research study is to assist adults with t2d in achieving the canadian 24-hour sedentary behaviour movement guidelines.

adults with type 2 diabetes (t2d) are less active and accumulate more sedentary behaviour (sb) than those without. among adults with t2d, increased sb is associated with increased mortality after adjusting for physical activity. canadian 24-hour sb movement guidelines recommend limiting sb to ≤8 hours, no more than 3 hours of recreational screen time, and breaking up long periods of sb as often as possible. therefore, the purpose of this research study is for adults with t2d to achieve these sb canadian 24-hour sb movement guidelines. to address this purpose, we will be conducting a six-week two-arm repeated measures randomized control trial. the intervention group will receive a theory-based behaviour change counselling session through zoom at week 0, mobile phone application at weeks 2 and 4 that encourage participants to create their own personal and specific action plans and coping strategies, and daily text messages that motivate participants to reduce and break up their sb. the control group will receive no intervention. the primary objective of the study is to reduce sb, while the secondary objectives are to break up sb, reduce screen time, improve quality of life, determine the perceptions towards the intervention, and validate the sb questionnaires. sb will be collected in the form of total daily sb, frequency of sb breaks, and duration of sb breaks. these variables will be measured through a sb and quality of life questionnaires that will be delivered through a downloadable mobile phone application. outcome measures will be compared within and between groups to detect differences.

Eligibility criteria:
inclusion criteria: * 18 years or older * diagnosed with type 2 diabetes * access to a smart phone with internet connection * be able to read, write, and speak in english exclusion criteria: * any medical or physical limitation that would prevent standing, stretching, and/or light physical activity
bilateral sacrospinous colposuspension (bsc) in the female genital prolapse with urinary urge symptomatology

Conditions: Urinary Urge Incontinence

Summary: prospective non-randomised trial investigating the effect of vaginal vault suspension on urge symptomatology in female patients with pelvic organ prolapse

a multicenter multinational trial is performed in 250 female patients with pelvic organ prolapse (pop) and symptoms of urinary urge incontinence. dependent on the presence or abscence of the uterus patients are treated with bilateral sacrospinous uterine or vaginal vault suspension (bsc) by means of a tape specifically designed for this purpose.

Eligibility criteria:
inclusion criteria: * urge urinary incontinence or symptoms thereof * 18 years old or older * compliance regarding data collection, therapy and follow-up * written informed consent * simultaneous performance of surgical colporrhaphy permitted exclusion criteria: * pelvic organ prolapse without symptoms of urinary urge * age less than 18 years * no informed consent * lack of compliance * adverse reaction to polypropylene * life expectancy less than anticipated duration of protocol * asa 4

Keywords: pelvic organ prolapse incontinence minimally invasive vaginal surgery macroporous lightweight mesh polypropylene pop urge
comparison of prs according to inhalation agent during ldlt

Conditions: Liver Transplantation; Postreperfusion Syndrome

Summary: the investigators tried to evaluate the effect of desflurane on the incidence of postreperfusion syndrome during living donor liver transplantation surgery. the investigators used sevoflurane as a comparison.


Eligibility criteria:
inclusion criteria: * elective ldlt exclusion criteria: * age \ 65 * patient refusal * re-transplantation
a study to investigate the potential pharmacokinetic interaction between tmc435 and methadone

Conditions: Hepatitis C

Summary: the purpose of this study is to evaluate the effect of steady-state (constant concentration of medication in the blood) tmc435 (150 mg, once a day) on the steady state pharmacokinetics (what the body does to the medication) of r- and s-methadone.

this is an open label (all people know the identity of the intervention) drug-drug interaction (tmc435 versus methadone) study. approximately 12 hepatitis c virus-negative opioid-dependent participants on stable maintenance therapy (for at least 30 days before screening) will be enrolled in the study. the study will consist of 3 phases: 1) run-in phase: during this phase, participants will take individualized (dose of methadone will be adjusted for each participant between a range of 30 and 150 mg daily) dose of methadone from day -14 (14 days before the first intake of tmc435) till day -1 (1 day before the first intake of tmc435), which will be supervised by the medical staff. 2) 7 days treatment phase: during this phase, the participants will take 150 mg dose of tmc435 once daily from day 1 to day 7 orally (by mouth) plus the individualized dose of methadone which will be supervised by the medical staff. 3) follow-up phase: during this phase, the participants will continue to take only the individualized dose of methadone for 30-32 days. safety evaluations will include assessment of adverse events, clinical laboratory tests, cardiovascular safety, physical examination and alcohol breath test. the total study duration will be of 22 days excluding screening and follow-up phase.

Eligibility criteria:
inclusion criteria: * receiving once daily oral methadone maintenance therapy at a stable individualized dose of 30 to 130 mg once daily for at least 30 days prior to screening * agreeing not to change the current methadone dose from screening until day7 included and to have a daily observed and documented methadone intake from day-14 until day8 and to have a daily observed and documented tmc435 intake from day1 until day 7 * having obtained approval from his/her addiction physician for participation in the trial and addiction physician agrees to provide medical care for the volunteer after discharge from the testing facility exclusion criteria: * no female of childbearing potential, except if using effective birth control methods during the trial and for at least 30 days after the end of the treatment period * no positive testing for drugs of abuse * no positive testing for hepatitis a, b and c and for hiv1 and 2 * impaired liver disease or other clinically relevant diseases

Keywords: hepatitis c hcv hepatitis c virus hcv negative protease inhibitor methadone tmc435
blood pressure following isometric exercise in inactive adults

Conditions: Hypertension; Elevated Blood Pressure; Sedentary Lifestlye

Summary: this study investigates how isometric exercise training (iet) affects blood pressure in physically inactive adults. isometric exercise involves sustained muscle contractions without movement-for example, pushing against a fixed object. previous research has shown that iet may help reduce blood pressure, but the mechanisms involved are not fully understood. the purpose of this study is to assess both the immediate (acute) and long-term (chronic) effects of iet on cardiovascular outcomes. participants will complete a series of lab-based exercise sessions over several weeks. in these sessions, they will perform repeated bouts of isometric leg extensions while seated on an exercise machine designed to measure muscle force. throughout the study, researchers will monitor participants' blood pressure, heart rate, and muscle activity. acute responses-such as post-exercise hypotension (a short-term drop in blood pressure)-will be measured immediately after exercise. chronic changes, such as resting blood pressure improvements, will be evaluated across the training period. additional measurements will include heart rate variability (hrv), which gives insight into autonomic nervous system activity, and electromyography (emg), which tracks muscle fatigue and activation patterns. these data will help explore potential mechanisms behind the cardiovascular benefits of iet. by examining how repeated sessions of isometric exercise influence blood pressure and related physiological responses, this research may support the use of iet as a non-pharmacological strategy for managing or preventing hypertension in physically inactive individuals.


Eligibility criteria:
inclusion criteria: * age 18 years or older * self-reported physically inactive or insufficiently active (not meeting current physical activity guidelines) * not currently engaged in structured resistance or isometric exercise training * able to attend lab sessions over a 4-week period * provides written informed consent exclusion criteria: * current diagnosis of hypertension requiring medication * any known cardiovascular, neurological, or musculoskeletal condition contraindicating isometric exercise * formal education or professional background in exercise science, physiology, or a related field * pregnant or planning to become pregnant during the study period * inability to follow verbal instructions or complete study protocols

Keywords: isometric exercise blood pressure post-exercise hypotension physical inactivity heart rate variability electromyography (emg) muscle fatigue cardiovascular adaptation exercise intervention non-pharmacological treatment hypertension prevention autonomic nervous system belief-bp
effectiveness of musical training in hong kong chinese childhood brain tumor survivors

Conditions: Brain Neoplasms; Child

Summary: this study aims to work out the effectiveness (effect size) of the musical training intervention in reducing depressive symptoms, improving self-esteem and quality of life among childhood brain tumour survivors and to examine the feasibility, appropriateness, and acceptability of implementing musical training intervention in clinical practice. subjects in the experimental group will receive weekly 45-minute lessons on musical training for one year (52 weeks), while those in the control group will receive usual care.

musical training has been increasingly implemented to promote one's psychological well-being and cognitive functioning. for instance, to reduce depression, anxiety in psychiatric patients, to improve self-esteem and mood recognition in hospitalized adolescent patients diagnosed with "adjustment reaction to adolescence", to improve social skills of children with autism, to enhance reading skills and academic achievement in young poor readers, and to facilitate children's cognitive development. nevertheless, the effectiveness of musical training in promoting psychological well-being, particularly to reduce their depressive symptoms and enhance self-esteem, and enhancing quality of life among the childhood brain tumour survivors is remain underexplored. it is of paramount importance to examine the effectiveness of musical training so as to ameliorate adverse disease- and treatment-related late effects, such as depression and low self-esteem, hence enhancing childhood brain tumour survivors' quality of life.

Eligibility criteria:
inclusion criteria: * hong kong chinese children surviving from brain tumours with the modified mini-mental scale (mmse) score of 18 or above * be aged between 7 and 16 years * able to speak cantonese and read chinese * have completed treatment for at least two months * have residual function of the upper extremities (i.e. be able to move the extremities, such as the fingers and arms, without assistance) exclusion criteria: * children who have undertaken any musical training following their cancer diagnosis * survivors with evidence of recurrence or second malignancies * survivors receiving palliative care
the chronic pain incidence after elective and urgent cesarean sections

Conditions: Chronic Pain

Summary: the purpose of this study is to determine the effects of whether urgent or elective cesarean section on the occurrance of chronic pain.

the purpose of this study is to determine the effects of whether urgent or elective cesarean section on the occurrance of chronic pain. patients aged between 18 - 45 years whose underwent urgent or elective cesarean section will be invited to participate in the study. preoperatively in operating theatre, patients will be asked to complete the pain catastrophizing scale (pcs) questionnaire. in postoperative 6 months after discharge, patients will be called by an investigator who is blind to the study to evaluate the presence of chronic pain. patients will be asked to grade the pain that they suffer using a numeric rating scale for the intensity of pain.

Eligibility criteria:
inclusion criteria: * female * 18 - 45 years of age * underwent elective or urgent cesarean section exclusion criteria: * not willing to participate in the study * can not reach by phone * use of anti-psychotic or anti-depressant drugs
orthotic use for chronic low back pain

Conditions: Chronic Low Back Pain

Summary: the purpose of this research study is to determine the change in perceived levels of pain and dysfunction in 50 patients with chronic low back pain, following the use of custom-made shoe orthotics for a three month period. the hypothesis of this study is that custom orthotic intervention will improve the patients' low back pain and dysfunction symptoms.


Eligibility criteria:
inclusion criteria: 1. males and females must be at least 18 years old. 2. subjects must be symptomatic with current pain between t12 and the sacroiliac joints with or without radiating pain. 3. symptoms must have been present for at least three months. exclusion criteria: 1. use of custom-made shoe orthotics in the past year 2. brain disorders (i.e.: dementia or alzheimer's disease) that would lead to difficulty in questionnaire completion. 3. active conservative care (such as physical therapy or chiropractic care) for the low back received in the last six months (excluding the use of oral medications or daily at-home exercises for general well-being). we do not want to over-treat the patient or have any cross-over effects within this study from previous treatment. 4. not fluent or literate in the english language. we will not be able to provide multiple translators within this pilot study. 5. current or future litigation for low back pain. 6. chronic pain other then low back pain such as fibromyalgia 7. low back surgery in last six months. 8. other conditions that may affect the outcomes of this study or exclude patients from participation in the study, including contraindications to orthotic use. 9. peripheral neuropathy due to disorders such as diabetes. 10. low back or leg pain that is not reproducible.
epidemiology study of malaria transmission intensity in sub-saharan africa

Conditions: Malaria

Summary: this study is designed to characterise p. falciparum transmission intensity in subjects aged ≥6 months and \<10 years by measurement of p. falciparum parasite prevalence, and to estimate the use of malaria control interventions at some centres selected for the epi-mal-002 and epi-mal-003 studies in sub-saharan western africa.

two subsequent studies (epi-mal-002 and epi-mal-003) are planned to monitor vaccine safety prior to and after implementation of the rts,s/as01 candidate malaria vaccine. epi-mal-002 will take place before rts,s is authorised and epi-mal-003 will start when rts,s is registered and authorised in the country. a cross-sectional survey at peak transmission will provide by-site point estimates of parasite prevalence (pp) and malaria control measure coverage in the areas participating in epi-mal-002/-003. epi-mal-006 will be conducted in advance of epi-mal-002/-003 in order to assess pp and malaria control measures to inform enrollment in these studies. the age group for enrollment (≥6 months - \<10 years) will permit analysis of pp according to the world health organization (who) definition (2-9 years) and by the joint technical expert group (jteg) suggested age (\<5 years).

Eligibility criteria:
inclusion criteria: * subjects' parent(s)/legally acceptable representative(s) \[lar(s)\] who, in the opinion of the investigator, can and will comply with the requirements of the protocol. * a male or female equal or more than 6 months of age and less than 10 years of age at the time of survey. * signed informed consent or thumb-printed and witnessed informed consent obtained from the parent(s)/lar(s) of the child. exclusion criteria: * child in care. * current active participation in any trial involving administration of an investigational malaria vaccine or malaria drug.

Keywords: saharan western africa epidemiology post-approval programme study malaria burden of disease study
buccal mucosal graft for onlay ureteroplasty in the management of proximal ureteral stricture

Conditions: Stricture Ureter

Summary: onlay uretroplasty with either grafts or flaps has been attempted by many reconstructive urologists, ln particular buccal mucosa graft (bmg) ureteroplasty has been reported by many centers and has shown its feasibility and safety

in cases of long segment upper ureteral stricture, more advanced surgical techniques, such as renal mobilization and downward nephropexy, ileal ureter replacement, transureteroureterostomy, and autotransplantation of the kidney, are necessary to provide a tension-free anastomosis. autotransplantation of the kidney needs more efforts, more experts and may lead to significant renovascular complications. also, there is severe metabolic and intestinal complications are associated with using of long intestinal segment in the management of ureteral stricture \[9\]. these previous side effects and difficulties make the management of long upper and middle ureteral strictures more complicated and indicate other lines of management urgently. even the ureteral stricture still not patent enough to drain urine but still, we can use it as a ureteral plate with little affection of its vascularity. based on this theory an onlay repair technique was emerged. onlay uretroplasty with either grafts or flaps has been attempted by many reconstructive urologists, ln particular buccal mucosa graft (bmg) ureteroplasty has been reported by many centers and has shown its feasibility and safety.

Eligibility criteria:
inclusion criteria: * proximal ureteral stricture or uretropelvic junction obstruction (upjo) which are not amenable for primery anastmosis. exclusion criteria: * buccal graft contraindications as i. active oral infections ii.oral cancers like cancers of lips, tongue or cheeks.

Keywords: buccal mucosa stricture ureteroplasty
the renal safety in patients with chronic hcv undergoing sofosbuvir containing antiviral therapy

Conditions: Egyptian Patients, HCV Treatment, Kidney Function

Summary: the aim of this study is to investigate the occurrence of aki during antiviral therapy, when compared with baseline values in egyptian patients. in addition, the study aims to evaluate the change in insulin resistance value after treating patients from hcv.

there are limited published data, currently, suggesting the risk of aki during oral direct acting antiviral treatment. most case reports and retrospective studies reported the presence of an intrinsic cause of renal injury, with most of the available biopsies showing acute tubular necrosis (atn) and acute interstitial nephritis (ain). most of these patients had returned to baseline renal function on cessation of sofosbuvir combination therapy. recently it was found that a notable percentage of patients experienced a transient increase in creatinine during therapy, which could occasionally lead to a more than 50% decrease in patients' egfr. previous studies had also shown that the co-use of nonsteroidal anti-inflammatory drugs (nsaids) and recurrent ascites were at increased risk for aki during sofosbuvir-based antiviral therapy (brawn et al., 2018). the primary endpoint of this study is to investigate the occurrence of aki in egyptian patients during antiviral therapy and to highlight its reasons and time of incidence in addition to the mechanism of this injury.

Eligibility criteria:
inclusion criteria: * age≥ 18 years chronic infection with hcv gt 4 no prior hcv treatment experience exclusion criteria: * co-infection with hbv or hiv, clinical evidence of ischemic heart disease, the presence of diabetic ketoacidosis, patients admitted to the intensive care unit (icu), or expected to undergo surgery during the study period, and child pough score c.

Keywords: hcv daas egyptian patients creatinine insulin resistence gfr
study to evaluate the efficacy, safety and pk of intravenous single injection lc28-0126 immediately before pci in stemi patients

Conditions: ST-segment Elevation Myocardial Infarction

Summary: evaluate the efficacy, safety and pharmacokinetics of intravenous single injection lc28-0126 immediately before percutaneous coronary intervention (pci) in patients with st-segment elevation myocardial infarction (stemi).


Eligibility criteria:
inclusion criteria: * age between 20 and 75 * within 12 hours after the onset of chest pain * st-segment elevation of more than 0.1 mv in two contiguous leads or new left bundle-branch block (lbbb) patients * signed for written informed consent exclusion criteria: * left main disease * multi-vessel disease
application of thrombin gel matrix for the prevention of lymphocele in patients with endometrial cancer.

Conditions: Lymphocele; Lymphocele After Surgical Procedure; Endometrium Cancer

Summary: to compare the incidence of lymphocele in endometrial cancer patients with thrombin gel matrix used and not used during pelvic lymph node dissection.

pelvic lymph node dissection is the most accurate staging tool to determine lymph node involvement in endometrial cancer. lymphoceles developed after surgery can cause serious morbidity, additional costs and delays in chemotherapy or radiotherapy. in this study, conventional pelvic lymphadenectomy will be compared with thrombin gel matrix application after pelvic lymphadenectomy. our goal is to prospectively assess the lymphostatic effect of thrombin gel matrix in endometrial cancer patients undergoing pelvic lymph node dissection.

Eligibility criteria:
inclusion criteria: * endometrial cancer patients who need laparotomic bilateral plnd * patients suitable for surgery exclusion criteria: * previous pelvic surgery * previous chemotherapy or radiotherapy * patients who undergo only lymph node sampling * patients who have not signed informed consent
long-working distance oct for children

Conditions: Retinal Diseases; Optic Nerve Diseases

Summary: young children age 6 month to 6 years are often not able to cooperate for advanced oct eye imaging. the purpose of this study is to investigate the use of a novel long-working distance swept source (ss) optical coherence tomography imaging system with fixation alignment for use first in young adults, older children, and then young children ages 6 months to 6 years. the investigator's future goal is to obtain important retinal and optic nerve information from oct in clinic in these young children.

the overall objective of this study is to examine the utility of a long-working distance high speed ssoct system along with technology to identify and use movies, etc. to aid with fixation. this study would be the first testing of such a system, first in adults and then moving to older children who could provide feedback, and then to young children. this imaging data will be compared to other clinical tests and images collected during regular health care and eye examinations.

Eligibility criteria:
inclusion criteria: * minor or adult undergoing eye examination at duke eye center * adults with normal eye health enrolled as controls exclusion criteria: * have any ocular disease that restricts the ability to perform oct scanning * minor under the age of 6 months

Keywords: optical coherence tomography (oct) swept source oct