Kornimate/medical-research-clean huggingface dataset:
bone adaptation to impact loading

Conditions: Osteoporosis

Summary: ageing populations have made osteoporosis and fragility fractures a major public health concern worldwide. half of all women and 30% of all men will suffer a fracture related to osteoporosis during their lifetime. while medical prevention of this immense problem is impossible at population level, it is necessary to find efficient preventive strategies. exercise is one of the major prevention approaches because one reason behind the increasing burden of osteoporosis is the modern sedentary lifestyle. however, the optimal type, intensity, frequency, and duration of exercise that best enhances skeletal integrity are still largely unknown. we conducted a 12-month population-based randomized controlled exercise intervention in 120 premenopausal women. the aim was to investigate the effect of impact exercise on bone mineral density, geometry and metabolism in healthy women with the intention of assessing the intensity and amount of impact loading with a novel accelerometer-based measurement device. training effects on risk factors of osteoporotic fractures, physical performance and risk factors of cardiovascular diseases were also evaluated. this study demonstrated that 12 months of regular impact exercise favoured bone formation, increased bone mineral density in weight-bearing bones, especially at the hip, and led to geometric adaptations by increasing periosteal circumference. bone adaptations had a dose- and intensity-dependent relationship with measured impact loading. changes in proximal femur were threshold-dependent, indicating the importance of high impacts exceeding acceleration of 4 g as an osteogenic stimulus. the number of impacts needed to achieve this stimulation was 60 per day. impact exercise also had a favourable effect on physical performance and cardiorespiratory risk factors by increasing maximal oxygen uptake, dynamic leg strength and decreasing low-density lipoproteins and waist circumference. changes were dose-dependent with impact loading at wide intensity range. bone adapts to impact loading through various mechanisms to ensure optimal bone strength. the number of impacts needed to achieve bone stimulation appeared to be 60 per day, comparable to the same number of daily jumps. if done on a regular basis, impact exercise may be an efficient and safe way of preventing osteoporosis.


Eligibility criteria:
inclusion criteria: * random population-based sample of women: * age 35-40 yr * residing in the city of oulu, finland * in march 2002 exclusion criteria: * cardiovascular, musculoskeletal, respiratory, or other chronic diseases that might limit training and testing * diseases or medication affecting the bone * pregnancy and breastfeeding * regular current or previous participation in impact-type exercises and long-distance running more than three times a week

Keywords: acceleration bone density cardiovascular diseases exercise female fragility fractures impact intensity intervention studies osteoporosis premenopause
"aida" protocol (lap 0493)

Conditions: Leukemia

Summary: the main purposes of the aida protocol are to test the role of intermittent maintenance therapy with atra, standard maintenance chemotherapy with methotrexate and 6-mercaptopurine of both in pcr negative patients at the end of the consolidation phase and to evaluate the role of allogeneic or autologous bone marrow transplantation in pcr positive patients at the end of the consolidation phase.


Eligibility criteria:
inclusion criteria: * age \> 12 months (1 year) and \< 75 years * morphological newly diagnosis of apl * presence of the pml-rara transcript * no cardiac contraindications to anthracycline chemotherapy * serum creatinine \<=2.5 mg/dl * serum alkaline phosphatase \<= 3 times the normal upper limit * serum bilirubin \<= 3 times the normal upper limit * serum sgot \<= 3 times the upper normal limit * negative pregnancy test * informed consent exclusion criteria: * age \ =75 years * absence of the pml-rara transcript * pregnant of lactating women * presence of active serious infections that are not controlled by antibiotics * prior treatment with antileukemic therapy (excluded corticosteroids) * presence of severe concomitant psychiatric disease * presence of other concomitant malignant tumors, except basal cell carcinoma * concurrent treatment with cytotoxic chemotherapy or radiotherapy * cardiac contraindications to anthracycline chemotherapy * serum creatinine \>2.5 mg/dl * serum alkaline phosphatase \> 3 times the normal upper limit * serum bilirubin \> 3 times the normal upper limit * serum sgot \> 3 times the upper normal limit * positive pregnancy test * absence of informed consent

Keywords: acute promyelocytic leukemia
respiratory muscle dysfunction in critically ill patients

Conditions: Sepsis; Mechanical Ventilation

Summary: respiratory muscle dysfunction in critically ill patients is associated with elevated morbidity, including prolonged weaning from mechanical ventilation. the causes for respiratory muscle dysfunction in these patients is poorly understood and no effective treatment is available. the general hypothesis of the present study is that in critically ill mechanically ventilated subjects respiratory muscle dysfunctions results from loss of myosin induced by activation of proteolytic cascades.


Eligibility criteria:
inclusion criteria: * severe sepsis / septic shock * clinical reason for laparotomy * \> 18 years exclusion criteria: * no informed consent * medical history of myopathy * unintended weight loss before icu admission * pregnancy * chronic use of corticosteroids

Keywords: respiratory muscle myosin mechanical ventilation
the detection of circulating tumor cells (ctcs) in patients with breast cancer undergoing cryosurgery combined with dc-cik treatment

Conditions: Neoplastic Cells, Circulating

Summary: circulating tumor cells (ctcs) have the potential to provide a surrogate for'real-time biopsy' of tumor biological activity. enumeration and molecular characterization of ctcs in breast cancer could play an important role in diagnosis, predicting the risk for tumor recurrence, and providing novel target therapy biomarkers. in view of these facts, the investigators wanted to demonstrate the value of multiparameter flow cytometry in detecting human tumor cells of breast cancer in normal peripheral blood after cryosurgery with or without dendritic cell(dc)-cytokine-induced killers(cik) treatment, and the investigators also compared the specificity with reverse transcriptase polymerase chain reaction (rt-pcr) method.

1 day before and 2 days after cryosurgery with or without dc-cik treatment，approximately 17-ml ethylene diamine tetraacetic acid(edta)-blood was drawn by vein puncture from patients with breast cancer and healthy volunteers. the blood of the healthy volunteers will be used to evaluate the sensitivity and specificity and as negative control cells. to avoid contamination with skin cells, 2 ml blood will be discarded before the study samples will be taken.briefly, the mononucleate cells will be separated from the blood over ficoll- paque for 20 min with 1800g at 4℃. the interface cells will be removed and washed, and the red blood cells(rbcs) will be removed using a lysis buffer followed by a repeated wash. the mononuclear cells will be counted and aliquot for rt-pcr and multiparameter flow cytometry on the basis of at least 2-3×106 cells for each methodology. the cell pellet will be resuspended in phosphate-buffered saline for multiparameter flow cytometry and in trizol reagent for rt-pcr. aim : identification of ctcs may lead to better diagnosis and prognosis and could help to choose an adequate therapy.

Eligibility criteria:
inclusion criteria: 1. age:18-75 2. karnofsky performance status \>60 3. diagnosis of breast cancer based on histology or the current accepted radiological measures. 4. classification tumor,nodes,metastasis-classification(tnm) stage: ⅱ,ⅲ,ⅳ 5. will receive cryosurgery and/or dc-cik treatment 6. life expectancy: greater than 3 months 7. patients' routine blood test, liver function and kidney function have no obvious abnormalities 8. ability to understand the study protocol and a willingness to sign a written informed consent document exclusion criteria: 1. patients with other primary tumor except lung cancer 2. history of coagulation disorders or anemia

Keywords: breast neoplasms circulating tumor cells
multicenter, open-label, safety and tolerability study

Conditions: Schizophrenia

Summary: this will be a multicenter, 52 week, open label study to assess the safety and tolerability of oral opc-34712 (1 to 6 mg) as monotherapy in adult patients with schizophrenia. the study will be conducted on an outpatient basis. enrollment into the study will be drawn from eligible subjects who have completed participation in study 331-07- 203 and who, in the investigator's judgment, would benefit from continued treatment with oral opc-34712.


Eligibility criteria:
inclusion criteria: 1. subjects who participated in 331-07-203 and who, in the opinion of the investigator, have the potential to benefit from continued administration of opc-34712 for the treatment of schizophrenia. 2. outpatient status at last visit of study 331-07-203. exclusion criteria: 1. sexually active males who are not practicing two different methods of birth control during the study and for 90 days after the last dose of study medication or who will not remain abstinent during the study and for 90 days after the last dose, or sexually active females of childbearing potential who are not practicing two different methods of birth control during the study and for 30 days after the last dose of study medication or who will not remain abstinent during the study and for 30 days after the last dose. if employing birth control, two of the following precautions must be used: vasectomy, tubal ligation, vaginal diaphragm, intrauterine device, birth control pill, birth control depot injection, birth control implant, condom, or sponge with spermicide. 2. females who are breast-feeding and/or who have a positive pregnancy test result prior to receiving open-label opc-34712. 3. subjects who during the course of their participation in 331-07-203 were treated in violation of the protocol or who developed any exclusion criteria during the course of their participation. 4. subjects who do not continue to meet all applicable inclusion/exclusion criteria for protocol 331-07-203 at the last visit (ie, week 6) of protocol 331-07-203. 5. subjects who represent a risk of committing suicide based on an answer of "yes" to either question 4 (active suicidal ideation with some intent to act, without specific plan) or question 5 (active suicidal ideation with specific plan and intent) on the "suicidal ideation" portion of the c-ssrs, or an answer of "yes" to any of the suicide-related behaviors (actual attempt, interrupted attempt, aborted attempt, preparatory acts or behavior) on the "suicidal behavior" portion of the c-ssrs. a subject who has had any suicidal ideation within the last 6 months, any suicidal behaviors within the last two years, or who in the clinical judgment of the investigator presents a serious risk of suicide should be excluded from the study. 6. subjects who would be likely to require prohibited concomitant therapy during the study. 7. any subject who, in the opinion of the investigator, should not participate in the study.

Keywords: schizophrenia
efficacy of an education protocol in the correction of inhalation techniques in copd

Conditions: COPD; Education

Summary: this study evaluates the implementation of an education protocol and its impact on the correct inhalation technique in copd patients presenting errors or mistakes. there will be 4 sessions, in each one the inhalation technique will be evaluated using a checklist of steps. whenever errors are found, the correct use of each device will be educated through verbal explanation and written material will be delivered.


Eligibility criteria:
inclusion criteria: * patients with copd diagnosed by spirometry (presence of a postbronchodilator fev1 / fvc ratio \<0.7) * over 40 years old * use any of the following devices: metered dose inhaler, handihaler, turbuhaler, diskus, aerolizer * have at least one error in the inhalation technique * signature of informed consent. exclusion criteria: * artificial airway * cognitive impairment noted in the medical history * hearing loss that complicates the compression of simple orders * bilateral amaurosis * functional dependence for the use of inhalers * presence of abnormal movements in the upper limbs that interfere and / or impede the correct use of the devices

Keywords: education copd inhalation devices
effects of iloprost on pulmonary hemodynamics and oxygenation in patients of chronic obstructive pulmonary disease during one-lung ventilation

Conditions: Video-assisted Thoracoscopic Surgery; Chronic Obstructive Pulmonary Disease

Summary: the inhaled iloprost, approved for pulmonary hypertension, caused increase in oxygenation, and increase exercise tolerance in ards or chronic obstructive pulmonary disease. inhaled iloprost has been researched in animal study, but not yet in human during one-lung ventilation. the investigators will enroll patients who diagnosed moderate to severe chronic obstructive pulmonary disease, preoperative pulse oximetry (spo2) of below 95% at room air or pao2 /fio2 ratio\< 150 mmhg after initiating one-lung ventilation. the primary outcome is pulmonary oxygenation expressed by pao2 /fio2 ratio. and secondary outcome is assessment of cardiac function including tei-index during nebulizing iloprost. the investigators hypothesized inhaled iloprost will improve oxygenation and decrease the fio2 in chronic obstructive pulmonary disease during one-lung ventilation.


Eligibility criteria:
inclusion criteria: 1. chronic obstructive pulmonary disease was defined as fev1/fvc ratio \< 0.7 and an fev 1 of 80% or less after inhalation bronchodilator : 1. above 40 years of age. 2. american society of anesthesiologists (asa) physical status ii, iii. 3. preoperative spo2 95 % or less at room air (spontaneous ventilation) or 4. pao2 /fio2 ratio\< 150 mmhg after initiating one-lung ventilation exclusion criteria: 1. severe functional liver or kidney disease 2. diagnosed hf (lv ejection fraction \<50% , or wall motion abnormality) 3. arrhythmia or received treatment with antiarrythmic drug . 4. severe bradycardia(hr \< 45 bpm) and av block 6. pathologic esophageal lesion (esophageal stricture or varix ) 7. pregnancy 8. pao2 /fio2 ratio ≥ 150 mmhg after initiating one-lung ventilation
performance and safety use of the nanostructured titanium dental implant "kontact n"

Conditions: Dental Implant; Dental Restoration; Edentulous Alveolar Ridge; Implant-supported Fixed Prosthesis

Summary: a multicenter prospective observational study in which aim is to illustrate the clinical outcome of dental implants "kontact n"; and the effects of its nanostructured surface on the osseointegration and secondary stability without increasing the rate of peri-implantitis. all the enrolled patients will be eligible for one or multiple implant-supported fixed restoration(s) according to the routine clinical practice and the manufacturer's instruction for use.


Eligibility criteria:
inclusion criteria: * edentulous patient (partially or completely and formerly, recently or just before implantation) requiring the placement of one (or more) dental implant (s) in maxillary or mandibular * age ≥ 18 years * good general health (asa score between \[1-2\]) * sufficient bone volume and quality (with or without bone graft) to support the implant * non-opposition of the patient for the collection of his medical data as part of the study (delivery of a patient's sheet) exclusion criteria: 1. poor oral hygiene 2. bruxism, parafunctional habits, occlusion disorders and / or temporomandibular joints 3. infections and oral inflammation such as periodontitis, gingivitis 4. patient with metabolic disorders (eg diabetes mellitus) or bone disease that may compromise peri-implant tissue healing 5. heavy smoker (\> 10 cigarettes / day) 6. patient with a pathology or immunosuppressive therapy such as chemotherapy, radiotherapy 7. patient on prolonged steroid therapy 8. titanium / titanium alloy allergy 9. alcohol or drug abuse 10. pregnant woman (or likely to be pregnant); or breastfeeding 11. difficulty of medical follow-up patients with geographical, social or psychological constraints 12. persons deprived of liberty or guardianship 13. involuntary / patient refusal to participate in the study

Keywords: nanostructured-implant titanium implant nano-roughness surface hydrophilic surface kontact n biotech dental
serratus anterior plane block , paravertebral block and quality of analgesia in patients with blunt chest trauma

Conditions: Analgesia

Summary: pain associated with rib movement cause inability to cough and breathe deeply that leads to reduction in the tidal volume and predisposes to significant atelectasis, sputum retention, pneumonia and a reduction in functional residual capacity .these factors in turn lead to decreased lung compliance, ventilation perfusion mismatch, hypoxemia and respiratory distress. therefore, effective pain relief remains the cornerstone of management to prevent serious respiratory complications .

thoracic paravertebral block and other regional techniques like intrapleural block and intercostal nerve blocks have variable success and high potential for local anaesthetic toxicity. serratus anterior plane block is relatively novel technique that is less invasive, easier to perform and improve pulmonary function that reduces the incidence of pneumonia, number of ventilator days, and mortality, especially those sustaining five or more rib fractures

Eligibility criteria:
inclusion criteria:patients aging from 20 to 70 years old. * asa physical status status i-ii -- patients suffering from blunt chest trauma with unilateral multiple rib fractures. exclusion criteria:• spinal cord injury. * epidural or spinal cord haematoma. * thoracic vertebral body fracture. * spinal injury awaiting assessment. * coagulopathy (platelets \ 1.5). * local infection or sepsis. * allergy to local anaesthetic. * inability to position patient due to associated injuries. * severe traumatic brain injury. * unstable lumbar or cervical spinal fractures. * hypotension. * hypovolaemia
measurement of the skin sympathetic nerve activity

Conditions: Skin Sympathetic Nerve Activity During General Anesthesia in Patients Undergoing Breast Cancer Surgery

Summary: sympathetic nerve activity can be measured transcutaneously in awake patients by computer-based filtering of raw signal obtained via skin leads attached on the chest. electrocardiogram can be removed by applying a high-pass filter setting of 150 hz. electromyogram can be filtered by applying a high-pass filter setting of 500 hz or a band-pass filter setting of 500-1000 hz. however, it is not known whether the skin sympathetic nerve activity (skna) can be measured in anesthetized and/or paralyzed patients. therefore, we planned this pilot study to observe whether the skna can be obtained in these patients. if the skna ca be observed, it will be presented in milivolt (uv).


Eligibility criteria:
inclusion criteria: * patients scheduled to undergo resection of breast cancer under general anesthesia after insertion of laryngeal mask airway exclusion criteria: * autonomic nervous system disease * medication acting on the autonomic nervous system * refuse to participate
taping for saliva control in cerebral palsy

Conditions: Cerebral Palsy

Summary: this study aim to investigate the effect of banding on saliva control and quality of life in children with cerebral palsy.

cerebral palsy describes a whole set of permanent disorders or disorders in the development of movement and posture, attributed to non-progressive disorders occurring in the developing fetal or infant brain, causing activity limitation. motor disorders are often accompanied by sensory, perception, communication and behavioral disorders, epilepsy and secondary musculoskeletal problems. kinesio taping has been proven to increase local circulation, reduce local edema and provide a positional stimulus for muscle, skin, or facial structures, regulating sensory input, and activating regions in the brain. kt is currently used to improve oral control in children with neurological and neuromuscular disorders and provides a reduction in saliva flow and frequency. however, knowledge of the potential of using neuromuscular bandages to manage the dribble flow has been limited.

Eligibility criteria:
inclusion criteria: * being a dribble control disorder, * having a diagnosis of cerebral palsy, * being between the ages of 5-15, * not allergic to kinesio taping tape. exclusion criteria: * using drugs for saliva control disorder, * botulinum toxin has been applied in the last 6 months, * active infection (tooth, intestine, etc.), * failure to comply with treatment, * swallowing disorder.

Keywords: saliva taping
effects of tnt on pain, rom and disability in patients with rc tendinopathy

Conditions: Rotator Cuff Tendinopathy

Summary: effects of tendon neuroplastic training on pain, range of motion and disability in patients with rotator cuff tendinopathy

rotator cuff tendinopathy is a condition where the shoulder's tendon suffers small tears or inflammation, often causing pain frequently arises from repetitive overuse or the natural aging process regular overhead activities can aggravate the shoulder's wear and tear, leading to tendinosis. the purpose of this study is to evaluate and compare the impact of tendon neuroplastic training with standard treatments on pain levels, functional disability, and the range of motion in patients suffering from rotator cuff tendinopathy. data were collected from riphah rehabilitation clinic lahore. nprs , goinmeter and spadi questioner were used before and after the intervention. assessment was done through the tool before and after the treatment.

Eligibility criteria:
inclusion criteria: * have a current shoulder complaint lasting at least three months prior to the time of enrollment * pain is located in the proximal lateral aspect of the upper arm (c5 dermatome) * positive hawkins-kennedy test exclusion criteria: * bilateral shoulder pain * less than 90 degrees of active elevation of the arm * corticosteroid injection within the last six weeks * radiologically verified fracture * glenohumeral osteoarthritis * surgery or dislocation of the affected shoulder * symptomatic arthritis in the ac joint * frozen shoulder * symptoms derived from the cervical spine

Keywords: rotator cuff tendiopathy tendon neuroplastic training disability range of motion pain