Kornimate/medical-research-clean huggingface dataset:
respiratory physiotherapy in type 2 diabetes and bariatric surgery

Conditions: Type 2 Diabetes; Bariatric Surgery Candidate

Summary: the aim of this study is to investigate the early effects of inspiratory muscle training (imt) applied before and after bariatric surgery on respiratory function, respiratory muscle strength and functional capacity in individuals with type 2 diabetes. the study will be conducted with 40 individuals with type 2 diabetes aged between 25-65. individuals will be randomly assigned to the imt (trained at 30% of maximum inspiratory pressure with an imt threshold device) and control group. as measurement parameters, a 6-minute walk test for functional capacity, a spirometry test for respiratory function, and a portable device (cosmed pony fx desktop spirometer, usa) will be used for respiratory muscle strength. hand grip strength will be measured with a baseline dynamometer. all measurements will be repeated on the first day before surgery and on the fourth day before discharge after surgery.

all patients will be evaluated with the same examinations on the first day before surgery and on the fourth day after surgery before discharge. individuals in the control group will only apply the hospital routine exercise program in the postoperative period. while individuals in the imt group will receive only imt on the first day before surgery, they will also receive the hospital routine exercise program in addition to imt treatment from the first day to the fourth day after surgery. during the training, the patient will undergo two 20-minute training sessions with a linear pressure resistance device, wearing a nose clip (threshold® imt-health scan products, usa) in a sitting position (ats/ets, 2002). imt training load will be adjusted according to the 30-40% pressure determined in the mip measurement. in the postoperative period, all patients will receive incentive spirometry, breathing exercises and ambulation exercises as part of the hospital routine exercise program.

Eligibility criteria:
inclusion criteria: • individuals with type 2 diabetes between the ages of 25 and 65 who applied to the general surgery department of büyük anadolu hospital and underwent bariatric surgery exclusion criteria: * individuals with a history of emergency surgery, * smoking, * exercising regularly in the last 6 months, * comorbidities with respiratory dysfunction, * pulmonary dysfunction, * acute copd exacerbation were excluded from the study.

Keywords: diabetes mellitus respiratory muscles bariatric surgery type 2
the effect of the drymouth shield on snoring

Conditions: Snoring

Summary: to measure the effect of the drymouth shield on snoring.

the primary outcome of this study is to aid in the final design of the drymouth shield and to assess the effect of the drymouth shield on snoring frequency. to accomplish this we will compare the frequency of snores during 1) overnight polysomnography without using the drymouth shield and 2) overnight polysomnography using the drymouth shield. secondary outcomes of the study will include: 1) compare the difference in the volume of snores without and with the use of the drymouth shield; 2) estimate the changes in apnea hypopnea index without and with the use of the drymouth shield; 3) describe symptoms of dry mouth without and with the use of the drymouth shield 4) describe symptoms of bruxism without and with the use of the dry mouth shield and 5) gather patient feedback about the user experience with the dry mouth shield.

Eligibility criteria:
inclusion criteria: 1. reports of snoring that disturbed a bed partner or housemate and 2. an objective measure of snoring such as a previous home sleep study, lab based polysomnography, or smart phone application with a snoring index of at least 20% exclusion criteria: 1. patient's with a body mass index of greater than 35 kilogram/meter squared. 2. a history of chronic lung disease with permanently impaired lung function testing. 3. a history of cardiovascular disease including but not limited to coronary artery disease or cerebrovascular disease. 4. current smokers. 5. patient's with a comorbid sleep disorder including but not limited to severe sleep apnea with an apnea hypopnea index of 30 events per hour, nocturnal hypoxia necessitating oxygen, current positive airway pressure use or restless legs syndrome 6. poor nasal patency in the judgment of the investigator 7. use of narcotics, benzodiazepines or other respiratory suppressing medication 8. females who are pregnant.
evaluation of the effect of music medicine application on menstrual symptoms

Conditions: Menstruation; Syndrome

Summary: in this study, the "music medicine application" method was chosen in line with the literature and guidelines and it is aimed to determine whether it is effective in reducing the symptoms experienced by female students with "music medicine application" during the menstrual period.

this study aims to determine whether the application of music medicine is effective in reducing the symptoms experienced by female students during the menstrual period. the type of research was planned as a prospective, randomized controlled experimental study with a pretest-posttest control group. the research will be conducted with female students studying at pamukkale university faculty of health sciences. the data of the research will be collected between march 2024 and february 2025. personal information form, visual analogue scale and menstruation symptom scale will be used to collect data. it was determined that a total of 62 people should participate in the research, 31 in the experimental group and 31 in the control group. as the randomization method, "simple randomization" will be used to ensure an equal number of samples in the experimental and control groups. randomization will be done using the www.randomizer.org application. the data will be analyzed using the spss (23.0) package program. continuous variables will be given as mean ± standard deviation and categorical variables will be given as number and percentage. significance test of difference between two means in comparing independent group differences when parametric test assumptions are met; when parametric test assumptions are not met, mann-whitney u test will be used to compare independent group differences.

Eligibility criteria:
inclusion criteria: 1. volunteering to participate in the research 2. menstrual cycle length has been within normal limits (21-35) for the last 3 months 3. not using oral contraceptives for the last 3 months 4. not having any psychiatric problems and not receiving any treatment for this in the last 3 months. 5. not using painkillers or any pharmacological agents or methods that reduce symptoms during the study. 6. participants who marked 1.1-10 according to visüel analog scala exclusion criteria: 1. presence of chronic diseases or serious medical conditions 2. presence of another physical or psychological disorder that may affect menstrual symptoms 3. presence of psychiatric or psychological disorders 4. active drug use or hormone therapy 5. having given birth 6. answering survey questions incompletely or not answering them 7. participants who marked 0-1 according to visüel analog scala 8. not applying music medicine for the experimental group

Keywords: music medicine menstruation symptom menstrual pain
endocuff-assisted vs. standard colonoscopy

Conditions: Colon Neoplasms

Summary: the aim of this study is to evaluate endocuff- assisted colonoscopy in terms of its possible additive contribution in the detection of important lesions, namely polyps and cancers, compared to standard colonoscopy, in a series of patients undergoing back-to-back screening or surveillance colonoscopies in a randomized fashion. moreover, we aim to assess possible changes regarding post-polypectomy surveillance programs following endocuff utilization.

tandem colonoscopies studies results, show that novel endoscopic technologies detect about 20% more adenomas than those conventional colonoscopy does (missed adenomas). since endocuff-assisted colonoscopy cannot be considered as a perfect examination, we hypothesize that conventional colonoscopy will detect one third of the missed adenomas that endocuff-assisted colonoscopy detects in a similar setting. therefore a sample size of 120 adenomas achieves 80% power to detect an odds ratio of 3.0 using a two-sided mcnemar test with a significance level of 0.05. the odds ratio is equivalent to a difference between two paired proportions of 14% which occurs when the proportion of detected missed adenomas during endocuff-assisted colonoscopy is 21% and the proportion of missed adenomas during conventional colonoscopy is 7%. during one year period before the study initiation, our colonoscopy performance quality data show that we detect a mean number of adenomas per patient equal of 0.7 in a population similar to the one recruited in our study. therefore, 172 patients overall will be required to detect 120 adenomas. given the uncertainty of our estimation and in order to cope with patients exclusions, withdrawals and unexpected incomplete colonoscopies, we decided to recruit 200 patients. a more extensive description regarding the investigators study is provided in the following fields.

Eligibility criteria:
inclusion criteria: * adults undergoing elective screening or surveillance colonoscopy * symptomatic adults with indication for colonoscopy exclusion criteria: * age\ 80 years * poor overall health (asa iii, iv) * recent abdominal surgery * presence of abdominal wall hernias * active colitis * previous bowel resection * inflammatory bowel disease * polyposis syndromes

Keywords: colonoscopy adenoma detection rate endocuff-assisted colonoscopy
recombinant human keratinocyte growth factor to reduce oral mucositis in hematologic malignancy patients undergoing peripheral blood stem cell transplantation after radiation and high-dose chemotherapy

Conditions: Stomatitis

Summary: radiotherapy and high dose chemotherapy with bone marrow transplantation or peripheral blood stem cell transplantation is frequently used as treatment for patients with cancers of the bone marrow or lymph nodes such as hodgkin's disease, non-hodgkin's lymphoma, leukemia or multiple myeloma. a common side effect of the radiotherapy and high dose chemotherapy is mucositis (inflammation of the inside of the mouth and throat resulting in pain and difficulty swallowing). mucositis is often very severe such that patients receive intravenous nutrition and pain medication in the hospital. in this study, an investigational recombinant human growth factor called keratinocyte growth factor (rhukgf) is being evaluated to determine its protective effect on the mucosal tissue and its ability to reduce the mouth and throat soreness.


Eligibility criteria:
inclusion criteria: \* patients with: non-hodgkin's lymphoma, hodgkin's disease, acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, chronic lymphocytic leukemia, or multiple myeloma \* eligible for fractionated total body irradiation (ftbi) plus high-dose chemotherapy followed by autologous pbpc support. \* 18 years of age or older \* karnofsky performance status greater than or equal to 70% \* minimum of 1.5 mio cd34+ cells/kg cryopreserved and to be transplanted \* informed consent for participation in the study exclusion criteria: \* history of, or concurrent cancer other than nhl, hodgkin's disease, aml, all, cml, cll, multiple myeloma \* prior bone marrow or peripheral blood stem cell transplantation \* purged stem cell product \* currently active infection or oral mucositis \* congestive heart failure \* serum creatinine \> 1.5x uln \* direct bilirubin \> 1.5x uln \* transaminases \> 3x uln \* corrected dlco \< 50% of predicted \* subject is currently enrolled in, or has not yet completed at least 30 days since ending other investigational device or drug trial(s) or is receiving other investigational agent(s). \* subject is pregnant (eg, positive human chorionic gonadotropin \[hcg\] test) or is breastfeeding. \* subject refuses to use adequate contraceptive precautions. \* known hypersensitivity to any of the products to be administered during dosing, including e coli-derived products. \* inability to give a truly informed consent.
magnetic resonance imaging (mri) hysterosalpingography versus radiographic hysterosalpingography in female infertility

Conditions: Female Infertility

Summary: the main objective of this study is to compare the data of hystérosalpingo-mri with intra cavitary injection of diluted gadolinium salts with the classic hysterography, which allows to realize at once with no irradiating examination, a complete assessment of the female infertility.

infertility is a disease which affects around 15% of couples (one union of seven) and has been increasing for 10 years. therefore, and due to the development of methods of medically assisted procreation, demand for infertility evaluation is steadily increasing. the infertility evaluation always begins with an accurate history, coupled with a physical examination of both partners. indeed, infertility of a couple is due to the female partner in about two thirds of cases, the male partner in the remaining third of cases. in women, the main observed causes are ovulatory function disorders (10 to 20%), tubal causes by proximal or distal occlusion (10%), uterine causes involving intra-uterine synechiae, leiomyomas, adenomyosis, mucosal polyps (5 %), inadequate cervical mucus or cervical stenosis , and peritoneal causes such as endometriosis and post-infectious or post-surgical peritubo-ovarian adhesions (20 %). medical imaging is one of the key methods to identify the different etiologies in men as in women. it will serve to clarify the etiology in question and assess the likelihood of subsequent pregnancy. the initial imaging assessment for infertility in any woman includes an endovaginal ultrasound examination and a hysterosalpingography (hsg) . the use of mri is considered as a second line in the absence of definitive diagnosis or to establish a definitive diagnosis before considering a targeted therapy. indeed the performance of mri for the diagnosis of pelvic endometriosis or fibroids mapping are well established. hsg is the imaging technique of choice to evaluate the morphology of the uterine cavity and tubal patency. but it has several important limitations. firstly it is an imaging method that uses x-rays and therefore delivers irradiation to the gynecological organs. moreover, it does not allow a precise exploration of the entire abdomen and pelvis: therefore, the physician cannot have a complete assessment of the etiologies of infertility with hsg. finally, it has a very good specificity but a relatively low sensitivity.

Eligibility criteria:
inclusion criteria: patient who a pelvic mri and an hysterography, part of an infertility assessment, have been prescribed by a gynecologist physician in nice university hospital. informed consent signed patient with social insurance age \> 18 exclusion criteria: contraindication to magnetic resonance imaging hysterosalpingography contraindication to radiographic hysterosalpingography
fatty infiltration in paraspinal muscles and lumbar erector spina plane block

Conditions: Low Back Pain

Summary: this study aimed to investigate the relationship between fatty infiltration in the lumbar paraspinal (multifidus and erector spinae) muscles, clinical characteristics, and treatment response after lumbar erector spinae plane block (espb) in patients with low back pain due to lumbar radiculopathy. a responder was defined as a patient with a numerical rating scale (nrs) decrease of ≥ 50% from baseline to one month after the procedure. the presence of fat infiltration in the lumbar paraspinal muscles was assessed, along with patient demographic and clinical characteristics.

low back pain (lbp) is a common health problem that causes global disability. lumbosacral radiculopathy (lr) is the most common cause of low back pain. disc herniation is the most common cause of lr, in addition to spinal stenosis, foraminal stenosis, facet joint hypertrophy, and degenerative disease (1). treatment options for lumbar disc herniation include conservative treatment, interventional pain management, and surgery. lumbar erector spinae plane block (espb) is an interventional procedure for chronic axial and radicular low back pain which that is unresponsive to conservative treatment. lumbar paraspinal muscles play an important role in maintaining lumbar spine stability. increased fat infiltration in the paraspinal muscles has been associated with high-intensity low back pain and poor functional status, and fat infiltration in the paraspinal muscles can be detected by lumbar magnetic resonance imaging. in this study, fatty infiltration in the bilateral lumbar multifidus muscles was evaluated at the l3 level using goutallier classification. the primary aim of this study was to investigate the potential relationship between the treatment outcome of lumbar espb and the degree of fatty infiltration in the paraspinal muscles in patients with chronic axial and/or radicular low back pain unresponsive to conservative treatments. the secondary aim was to identify other factors that may be associated with a successful response to lumbar espb and fatty infiltration of the paraspinal muscles.

Eligibility criteria:
inclusion criteria: * lumbar radicular pain * no response to conservative treatment for \> 3 months * mri within 1 year prior to injection. exclusion criteria: * inadequate medical records with missing numerical rating scale (nrs) scores and mri images * patients lost to follow-up within one month after lumbar espb * patients with a history of surgery for lumbar disc herniation * patients with severe spinal and/or foraminal stenosis * patients with extruded, sequestrated, or migrating hernias.

Keywords: plane block low back pain lumbar radiculopathy fatty infiltration erector spinae muscles
role of il 12 and il 23 as potential biomarkers in diagnosis of early crohn's disease

Conditions: Interleukin 12; Interleukin 23; Biomarker; Diagnosis; Crohn Disease

Summary: this study aims to evaluate the role of interleukin (il)-12 and il-23 as potential biomarkers in the diagnosis of early crohn's disease.

crohn's disease (cd) is characterized by periods of remission and relapse, with symptoms ranging from abdominal pain and diarrhea to severe complications such as fistulas and intestinal obstruction. interleukins (ils) are known clusters of cytokines that regulate the proliferation, development, and activation of immune cells. il-12 is predominantly a pro-inflammatory cytokine secreted by antigen-presenting cells (apc) in response to sensing of microbial components by toll-like receptors. another member of this family, il-23 is also produced by dcs and macrophages after toll-like receptors (tlrs) engagement.

Eligibility criteria:
inclusion criteria: * age from 18 to 65 years. * both sexes. * patients who are suspected of having crohn's disease clinically and by colonoscopy (like ulcers, fistulas, or skip lesions). * non-specific ileitis by histopathology. exclusion criteria: * patients with no pathological samples through colonoscopy. * history of other significant gastrointestinal diseases (e.g., colon cancer, ischemic bowel disease). * immunosuppressive therapy or biologic agents at the time of study. * previous abdominal surgeries.
assessing the safety and efficacy of mk-5592 (posaconazole) in japanese participants with fungal infection (mk-5592-101)

Conditions: Aspergillosis

Summary: the primary objective of this study is to assess and compare the safety of posaconazole with voriconazole in japanese participants with aspergillosis.


Eligibility criteria:
inclusion criteria: * body weight \>=45 kg * can be treated by taking tablet orally or intravenous (iv) formulation via central vein * female has a negative pregnancy test * female of non-childbearing potential; or if of childbearing potential, agrees to use proper combination of barrier method of birth control * met screening criteria for either invasive aspergillosis, chronic pulmonary aspergillosis, zygomycosis or fusariosis. exclusion criteria: * has a fungal infection other than aspergillus any species (spp.) zygomycetes (including mucor spp.) and fusarium spp. infection * has allergic bronchopulmonary aspergillosis, allergic sinusitis of aspergillosis, or aspergillosis of the eye * has long-term inactive aspergilloma not expected to respond to investigational product * is not expected to survive study duration * has an underlying disease, complication and systemic condition which makes it difficult to evaluate effect of study drug * has received, or continues to receive any systemic antifungal therapy, and cannot discontinue this treatment; but if fungal infection does not improve, can switch to study drug * is expected to need prohibited medications * has received posaconazole, has received voriconazole for this infection in the past and has deep-seated fungal infection that has not responded to this treatment, has intolerance for azole antifungal treatments, or is receiving antifungal combination therapy for chronic pulmonary aspergillosis * has known hypersensitivity to any medication * has history of either torsade de pointes, myocardial infarction within previous 90 days, has congenital or acquired long qt interval syndrome, or unstable cardiac arrhythmia * has significant liver dysfunction * has liver cirrhosis or cholestasis * has renal insufficiency * has a known hereditary problem of either galactose intolerance, lapp lactase deficiency, or glucose-galactose malabsorption * has acute symptomatic pancreatitis within 6 months of study entry or chronic pancreatitis * has an active skin lesion consistent with squamous cell carcinoma or melanoma, or within prior 5 years a history of malignant melanoma * has known or suspected gilbert's disease * female is pregnant, or nursing, or intends to become pregnant within 14 days after end of study.
breast augmentation rehabilitation program

Conditions: Breast Implants; Surgery, Plastic

Summary: the purpose of this study is to determine whether implementing a rehabilitation program can improve the post-operative time to pain free living after breast augmentation.


Eligibility criteria:
inclusion criteria: * women who undergo endoscopic transaxillary subpectoral breast augmentation * women above the age of 18 years * women with a bmi 18-27 exclusion criteria: * women who underwent previous breast reconstruction (cosmetic or therapeutic) * women who underwent previous chest surgery * women with previous chest trauma * women who underwent previous shoulder/arm surgery * women with previous shoulder/arm injury * women who smoke * women who are immunocompromised

Keywords: rehabilitation reconstructive surgery