Kornimate/medical-research-clean huggingface dataset:
change of pulmonary function after incentive spirometer training in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: this study was designed to examine the effect of incentive spirometry in pulmonary rehabilitation of children with cerebral palsy. the incentive spirometer, a device that can help improve breathing and strengthen inspiratory muscles. if the patient assigned to training group, the subjects started to respiratory muscle strengthening exercise using incentive spirometry. the training was performed ten sessions daily, for 4 weeks. respiratory function tests including forced vital capacity, forced expiratory volume in 1 second, peak cough flow, maximal phonation time were compared before interventions and at the end of exercise.


Eligibility criteria:
inclusion criteria: * male or female, 4 to 18 years * patients who are committed to comply with protocol-required procedures * gmfcs (gross motor function classification system) level ii, iii, iv * stable medical condition in the investigator's opinion * acceptable chest radiologic result who has no evidence of pulmonary disease exclusion criteria: * any uncontrolled clinically significant medical condition other than the one under study * patients with cognitive impairment who are unable to comply with protocol-required procedure * patients with presence or history of tracheostomy * patients who are taking medications that can affect respiratory function
a comparative clinical and radiographic study of collagen based pulpotomy in cariously exposed vital primary molars

Conditions: Dental Caries in Children

Summary: to assess post operative pain and survival rate after collagen based pulpotomy versus mta pulpotomy in children with vital primary molars.

pulpotomy of vital primary molars is indicated when caries removal results in pulp exposure. treatment approaches consist of devitalization using formocresol, preservation using ferric sulfate and regeneration using mineral trioxide aggregate of the remaining pulp tissue have been utilized to date. the ideal pulpotomy medicament would be biocompatible and bactericidal, in addition, to promote the healing of the root pulp and be compatible with the physiological process of root resorption. collagen, which is available for dental implication, is already sterilized and also reinforced with antibiotic particles to efficiently aid in regeneration and repair without any contaminations. the collagen particles can be sterilized by various methods like irradiation, dry heat, and ethylene oxide, among which irradiation is the most frequently used method as it does not affect the structural stability

Eligibility criteria:
inclusion criteria: 1. primary molar tooth not more than one-third of root resorption. 2. children with bilateral deep dental caries approximating the pulp in primary molars assessed both clinically and radiographically. 3. systemically healthy. 4. cooperative patients who will comply to follow up visits. exclusion criteria: 1. children with medical, physical, or mental conditions. 2. primary molars with any congenital deformities. 3. previously accessed teeth. 4. at operative procedure haemorrhage control is unachievable after pulpotomy.
internet-based psychotherapy for depressed elderly

Conditions: Depression

Summary: this study aims to evaluate the effectiveness of internet-based cognitive behavioral therapy (cbt) for depressed elderly.

individuals of age 60+ with symptoms of depression will be assessed before the study. at week 0, participants who meet eligibility requirements will be randomized either to intervention group which will participate in an 8-week internet-based modular cbt or to a delayed treatment control group.

Eligibility criteria:
inclusion criteria: * depressive symptoms * have access to a computer/tablet/smartphone and to the internet * have good knowledge of the lithuanian language exclusion criteria: * alcohol addiction * presently in any other psychological treatment * severe depression * suicidal ideation * significant change in psychiatric medication (during last 6 weeks)

Keywords: depression internet-based cognitive behaviour therapy elderly ehealth
a study of the safety and efficacy of bimatoprost in patients with glaucoma or ocular hypertension

Conditions: Glaucoma; Ocular Hypertension

Summary: a one month study which will determine the safety and efficacy of bimatoprost eye drops in patients with glaucoma or ocular hypertension


Eligibility criteria:
inclusion criteria: * chronic glaucoma or ocular hypertension * iop controlled on xalatan exclusion criteria: * uncontrolled medical conditions * known hypersensitivity to study medications
modality of adjuvant radiotherapy and chemotherapy for stage ⅲ endometrial cancer

Conditions: Endometrial Cancer

Summary: endometrial cancer is the most common gynecological malignancy affecting women's health. about 15% of the patients will have local late disease (stage iii) with high risk of recurrence and tumor related mortality. there is a consensus that adjuvant radiochemotherapy is needed for stage ⅲ endometrial cancer, but the best modality of radiochemotherapy is still uncertain. the retrospective data of our center showed that the sequential radiochemotherapy of "chemotherapy-radiotherapy-chemotherapy" in the "sanwich" mode could improve the survival outcome in patients with advanced endometrial cancer. a multicenter, prospective, randomized controlled study to compare the "sanwich" mode of radiochemotherapy and the "concurrent chemoradiotherapy followed by chemotherapy" mode will be carried out to determine the better modality of radiochemotherapy in stage iii endometrial adenocarcinoma.


Eligibility criteria:
inclusion criteria: 1. patients of primary treatment 2. all patients must have undertaken comprehensive staging operation（surgery must have included a hysterectomy and bilateral salpingooophorectomy and surgical staging). 3. patients with endometrial adenocarcinoma confirmed by postoperative patholog. 4. all patients with surgical stage iii endometrial carcinoma according to figo 2009 staging criteria. 5. entry into the study is limited to no more than 8 weeks from the date of surgery. 6. patients with adequate organ function, reflected by the following parameters: 1. wbc ≥ normal value of the institution; 2. absolute neutrophil count (anc) ≥ normal value of the institution; 3. platelet count ≥ 100,000/mcl; 4. sgot, sgpt, and alkaline phosphatase ≤ 1.25 x upper limit of normal (uln) ; 5. bilirubin ≤ 1.5 x uln; 6. creatinine ≤ institutional uln. 7. patients with a karnofsky score≥60. 8. the patients should voluntarily join the study, sign an approved informed consent with good compliance and cooperation with the follow-up. exclusion criteria: 1. patients who have received prior adjuvant therapy (radiotherapy or chemotherapy or endocrine therapy). 2. patients with residual tumor after surgery. 3. patients with other invasive malignancies. 4. patients with contraindications of radiotherapy and chemotherapy (with a history of myocardial infarction within 3 month, unstable angina pectoris or history of uncontrolled arrhythmia s from the date of registration) and who cannot receive postoperative adjuvant radiotherapy and chemotherapy. 5. patients with an estimated survival of less than 6 months. 6. those who are unable or unwilling to comply with the research requirements

Keywords: radiochemotherapy sanwich mode
investigation of the effect of pelvic floor exercise programme in elderly.

Conditions: Pelvic Floor Muscle Weakness; Urinary Incontinence in Old Age; Sexual Dysfunction; Quality of Life

Summary: alteration of hormonal structure and decreasing of muscle tissue with aging causes pelvic floor dysfunction. over age of 65 so many factors such as decrease in volume of muscle tissue, decrease in the amount of estrogen / testosterone, and low level of physical activity cause problems such as incontinence, prolapse, constipation and sexual dysfunction the aim of this study is to investigate the effectiveness of pelvic floor exercise program on sexual dysfunction, incontinence, quality of life and physical activity level in elderly.

pelvic floor problems including prolapse, voiding and defecation dysfunction have been seen in approximately 37% of women aged 60-79 years and incontinence is the leading pelvic floor dysfunction. the international incontinence society (ics)defines that all types of involuntarily urinary leakage as urinary incontinence. the incidence of urinary incontinence is 26.6% in women aged 65-74 and 41.8% in patients aged 75 and over. sexual dysfunction is also frequently encountered problem in pelvic floor disorders in people older than 65 years. the aim of this study is to investigate the effectiveness of pelvic floor exercise program on sexual dysfunction, incontinence, quality of life and physical activity level in elderly. pelvic floor exercises programme contains different contractions of pelvic floor muscle. each exercises have slow and fast twitch muscle exercise contraction.

Eligibility criteria:
inclusion criteria: to be aged over 65 to attend all exercise class not to be communication problem exclusion criteria: to have neurogenic bladder to have metastatic prostate or ovary cancer to have enfection in urinary tractus to have pelvic organs malign diseases

Keywords: pelvic floor exercise urinary incontinence sexual dysfunction
intervention for emotions in caregivers of dementia

Conditions: BPSD; Expressed Emotion; Depressive Symptoms

Summary: this study aims to evaluate the effectiveness of a 6-week caregivers of dementia processing emotions (cope) program using the integrative therapy to reduce ee (primary outcome) in family caregiver of plwd to alleviate the caregivers' depression, improve social dynamic with the plwd, and mitigate the perceived stress from bpsd (secondary outcomes).

a dual-modal (face-to-face and online approaches), client-customized caregivers of dementia processing emotions (cope) program can be developed to address ee in caregivers, such as (1) reduce caregivers' ee, (2) reduce caregivers' depressive symptoms, (3) reduce the behaviorally interactive social dynamic of maladaptation (i.e., dysfunctional dyadic relationship and quality of care), and (4) improve caregivers' perceived stress from plwd's bpsd.

Eligibility criteria:
inclusion criteria: * with a high level of expressed emotion as indicated by a cut-off score of 35 or above on the family attitude scale (chinese version; fas-c);(kavanagh et al., 1997; van humbeeck et al., 2002; yu et al., 2016) * provides care at least 4 hours per day;(moon \& adams, 2013) * consent to participate, and * no acute psychiatric illness. exclusion criteria: * with a low level (scored lower than 35 on fas-c) of expressed emotion * do not provide consistent or sufficient care (fewer than 4 hours per day) to plwd * do not consent to participate; * with comorbid acute psychiatric illness.

Keywords: dementia care caregiver burden integrative intervention
efficacy of lycra garments in ataxic subjects

Conditions: Ataxia, Cerebellar

Summary: the aim of this study iss to analyze the effect of lycra garments in the axial stabilization in subjects affected by ataxia, both in acquired cerebellar injuries and malformative etiology. improvement are expected for what concerns: * greater stability during stance * smoother walking pattern * reduction of risk of fall. the two groups (acquired and malformative) will be compared.


Eligibility criteria:
inclusion criteria: * subjects recruited must show a framework of ataxia consequent to acquired brain injury or malformative etiology. * subjects must be able to walk autonomously without any device exclusion criteria: * presence of spasticity or muscular contractures * subjects who already used lycra garments
a study of jnj-77242113 for the treatment of participants with moderate to severe plaque psoriasis (iconic-advance 2)

Conditions: Plaque Psoriasis

Summary: the purpose of the study is to evaluate how effective jnj-77242113 is in participants with moderate to severe plaque psoriasis compared to placebo and deucravacitinib.


Eligibility criteria:
inclusion criteria: * diagnosis of plaque psoriasis, with or without psoriatic arthritis (psa), for at least 26 weeks prior to the first administration of study intervention * total body surface area (bsa) greater than or equal to (\>=)10 percent (%) at screening and baseline * total psoriasis area and severity index (pasi) \>=12 at screening and baseline * total investigator global assessment (iga) \>=3 at screening and baseline * candidate for phototherapy or systemic treatment for plaque psoriasis exclusion criteria: * nonplaque form of psoriasis (for example, erythrodermic, guttate, or pustular) * current drug-induced psoriasis (for example, a new onset of psoriasis or an exacerbation of psoriasis from beta blockers, calcium channel blockers, or lithium) * a current diagnosis or signs or symptoms of severe, progressive, or uncontrolled renal, liver, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, psychiatric, or metabolic disturbances * known allergies, hypersensitivity, or intolerance to jnj-77242113, deucravacitinib or to any of the excipients or components of the study intervention * major surgical procedure, (for example, requiring general anesthesia) within 8 weeks before screening, or will not have fully recovered from surgical procedure, or has a surgical procedure planned during the time the participant is expected to participate in the study
mom nest study: maternal opioid medication: naltrexone efficacy study

Conditions: Opioid-use Disorder; Neonatal Abstinence Syndrome; Pregnancy, High Risk; Alcohol Use Disorder

Summary: this is a multi-center prospective comparative cohort study examining the safety, efficacy, pharmacokinetics, and pharmacogenomics of naltrexone for pregnant women with opioid use disorder. pregnancy, delivery, and maternal and infant outcomes to 12 months post-delivery will be examined and compared with a cohort treated with buprenorphine/naloxone.

fifty pregnant women stabilized pre-pregnancy on oral or extended-release naltrexone (xr-ntx) and 50 comparison women on buprenorphine/naloxone (bph) from boston medical center and the university of north carolina will be enrolled in this multi-center prospective comparative cohort study. the specific aims of this project are: 1) safety and efficacy: to compare maternal outcomes (safety, relapse, retention in care), fetal outcomes (growth, fetal distress), and infant outcomes (neonatal abstinence syndrome, growth, neurodevelopment) during pregnancy until 12 months post- delivery; an exploratory part of this aim is to collect safety and efficacy data on women receiving ntx for alcohol use disorder (aud). we will collect maternal, fetal and infant outcomes related to prenatal alcohol exposure. 2) pharmacokinetics: to determine the pharmacokinetics of ntx in pregnant and postpartum women; 3) genetics and epigenetics: to examine the association between genetic variants and epigenetic modification in the mu-opioid receptor (oprm1) gene, as well as global dna methylation changes after treatment with ntx and bph within the mother, placenta, and infant; and 4) breast milk: to measure breast milk concentrations of ntx and corresponding infant relative dose to determine safety for lactating women.

Eligibility criteria:
inclusion criteria: * pregnant women between 6 - 30 6/7 weeks gestation, receiving prenatal care at boston medical center (bmc) or the university of north carolina (unc) * plan to deliver infant at bmc or unc * diagnosis of opioid use disorder (oud) or alcohol use disorder (aud) in the current pregnancy on prescribed oral or extended-release naltrexone; or buprenorphine/naloxone for the treatment of oud * english speaking * singleton pregnancy exclusion criteria: * oud on prescribed methadone, or no maintenance medication * oud on subutex formulation of buprenorphine * severe psychiatric illness or cognitively impairing ability to provide informed consent * current maternal incarceration * women who present for care \>31 0/7 weeks * multiple gestation pregnancy

Keywords: naltrexone buprenorphine/naloxone maternal relapse retention in care pharmacokinetics pharmacogenetics
next-generation pre-operative targeting for thalamic dbs in the treatment of tremor

Conditions: Essential Tremor

Summary: researchers are investigating improved methods of targeting deep brain stimulators for treatment of essential tremor relying on brain connectivity measures derived from mri.


Eligibility criteria:
inclusion criteria: * diagnosis of refractory essential tremor scheduled for unilateral thalamic deep brain stimulator placement * age ≥ 18 years exclusion criteria: * prior deep brain stimulator, stereotactic radiosurgery, or focused ultrasound procedure for treatment of tremor * presence of concomitant movement disorder (e.g. parkinson's disease, dystonia, etc.) * known pre-existing structural brain abnormality (e.g, infarction, tumor, prior brain surgery, etc.) * contraindication to 3 tesla brain mri (e.g. incompatible implanted device) * pregnant

Keywords: deep brain stimulation
managment and outcome of urinary bladder trauma after gynaecological and obstetric operations

Conditions: Urinary Bladder Trauma

Summary: we aimed to evaluate the management and outcome of bladder trauma after gynecological and obstetric operations at assiut university hospital and to evaluate the methods of treatment of these complications. we aimed to find out risk factors for vesico uterine fistula after bladder trauma

the female genital and urinary systems are closely related embryologically and anatomically. the surgeon should know the anatomy of this area to avoid urinary tract (ut) injuries during obstetric (obst) and gynecologic (gyn) surgeries (solyman et al., 2022) ut injuries during obst/gyn surgeries are rare but have a significant psychological impact on both patient and surgeon, and their medico legal aspects are very bothering (safrai et al., 2022) ut injuries during obst/gyn operations range from 0.3 to 1% (blackwell et al., 2018) most cases are bladder injury, approximately three times more than ureteral injury (wong et al., 2018) the primary goal of the obst/gyn surgeon is to avoid ut injuries during his procedure. still, in some situations, this will be difficult as in patients with abnormal anatomy, difficult operations as in the presence of severe bleeding or pelvic adhesions, and with surgeons with low experience. immediate intraoperative repair of these injuries is optimal. in some cases, diagnosis and management are delayed postoperatively(patel and heisler, 2021) ut injuries during obst/gyn operations are either acute injuries such as bladder and ureteral laceration, and ureteral ligation identified immediately intra operatively or chronic injuries as fistula formation and stricture ureter, which are discovered later on (lee et al., 2012) iatrogenic urological complications from gynecological surgery can be prevented and reduced by complying with standard surgical

Eligibility criteria:
inclusion criteria: - all patients with urinary bladder injuries related to obst/gyn operations exclusion criteria: * no exclusion criteria in all patients with bladder trauma after gyn \&obs operations

Keywords: urinary bladder trauma after gynaecological and obstetric operations
clinical evaluation of therapy™ cool path™ duo cardiac ablation system for the treatment of typical atrial flutter (afl)

Conditions: Typical Atrial Flutter

Summary: the purpose of this study is to demonstrate that ablation with the therapy™ cool path™ duo cardiac ablation system can eliminate typical atrial flutter and that its use does not result in an unacceptable risk of serious adverse events (sae's).

this is a prospective, multi-center, non-randomized study (historical data as control) for the evaluating the safety and efficacy of therapy tm cool pathtm duo ablation system for the treatment of typical atrial flutter (cavo-triscupid isthmus dependent)

Eligibility criteria:
inclusion criteria: * a signed written informed consent * presence of typical atrial flutter (cavotricuspid isthmus dependent) * if subjects are receiving antiarrhythmic drug therapy (class i or class iii aad)for an arrhythmia other than typical atrial flutter, then the subject needs to be controlled on their medication for at least 3 months. if the subject had typical atrial flutter before starting the aad(s) (class i or class iii) and then subsequently had another arrhythmia (i.e. atrial fibrillation), then the 3 month aad criteria will not apply. * one documented occurrence of the study arrhythmia documented by ecg, holter, telemetry strip, or transtelephonic monitor within the past 6 months * in good physical health * 18 years of age or older * agree to comply with follow-up visits and evaluation exclusion criteria: * prior typical atrial flutter ablation treatment * pregnancy * atypical flutter or scar flutter(non-isthmus dependent) * significant coronary heart disease or heart failure; that is unstable angina pectoris and/or uncontrolled congestive heart failure (nyha class iii or iv) at the time of enrollment * a recent myocardial infarction within 3 months of the intended procedure date * permanent coronary sinus pacing lead * tricuspid valvular disease requiring surgery and/or a prosthetic tricuspid heart valve (i.e. significant) * evidence of intracardiac thrombus or a history of clotting disorders * participation in another investigational study * cardiac surgery within 1 month of the intended procedure date * allergy or contraindication to heparin

Keywords: cavo-tricuspid dependent