surgical treatment of peri-implantitis defects

Conditions: Peri Implantitis

Summary: the aim of this study is to evaluate the efficacy of implant surface decontamination using electrolysis cleaning system. and to evaluate the adjunctive use of l-prf in promoting soft tissue healing and long-term stability of the peri-implant marginal bone in the surgical treatment of peri-implantitis.

research design * prospective, in which participants will be recruited and then followed up throughout a specified period of time. * randomized, parallel designed, concurrent controlled trial with participants randomly allocated to either control or test groups. * single-blinded as the outcome accessors will be blinded to the intervention. materials and methods: patients attending dubai dental hospital and requiring treatment of peri-implantitis will be invited to take part in this randomized controlled trial based on the following inclusion and exclusion criteria: inclusion criteria: * aged 18 or over. * require treatment of peri-implantitis (defined as the presence of bleeding and/or suppuration on gentle probing, probing depths of ≥ 6 mm, presence of bone loss beyond crestal bone level changes resulting from initial bone remodeling). * screw retained implant crown. * good compliance and commitment to attend follow-up review appointments. * willing to provide informed consent. exclusion criteria * history of surgical therapy of peri-implantitis. * peri-implant defects indicated for regenerative procedure (i.e. contained bony defect). * cement retained implant crown. * systemic/local antibiotics during the previous 6 months. * bone metabolic disease and/or taking medications that affect bone metabolism. * history of malignancy, radiotherapy or chemotherapy. * pregnant or lactating women. * smokers the study will be conducted following the ethical standards of the declaration of helsinki in 1975, as revised in 2013 and the consort statement will be used as a guideline in reporting this study. randomization, allocation concealment and blinding: the participants will be randomly allocated to three equally sized groups using computer-generated numbers: control group (c): conventional open flap debridement test group 1 (t1): open flap debridement using (galvosurge® - straumann) test group 2 (t2): open flap debridement using (galvosurge® - straumann) combined with l-prf application

Eligibility criteria:
inclusion criteria: * aged 18 or over. * require treatment of peri-implantitis (defined as the presence of bleeding and/or suppuration on gentle probing, probing depths of ≥ 6 mm, presence of bone loss beyond crestal bone level changes resulting from initial bone remodeling). * screw retained implant crown. * good compliance and commitment to attend follow-up review appointments. * willing to provide informed consent. exclusion criteria: * history of surgical therapy of peri-implantitis. * peri-implant defects indicated for regenerative procedure (i.e. contained bony defect). * cement retained implant crown. * systemic/local antibiotics during the previous 6 months. * bone metabolic disease and/or taking medications that affect bone metabolism. * history of malignancy, radiotherapy or chemotherapy. * pregnant or lactating women. * smokers