Kornimate/medical-research-clean huggingface dataset:
robustness predictive factors in people aged over 75 years after going to the emergency room (rob-u)

Conditions: Aging; Emergency Room; Risk Factors

Summary: after emergency room visits, the elderly patients can increase their dependence and functional decline. in this context the goal of this study is to demonstrate that there are robustness predictive factors after visit to the emergency room.

the emergency department is one of the main access routes to the hospital for elderly patients. older age is often associated with an increase risk of longer stay in the emergency room with a high subsequent risk of hospital re-admission. one of the essential care objectives when treating these patients is to maintain the autonomy to avoid any dependence in order to keep the quality of life, and limit the time of hospitalization. emergency room visits and hospitalizations are too often considered as a source of autonomy loss aggravation in the elderly. many studies have demonstrated the mortality predictive factors existence, functional decline, or re-hospitalization of the elderly after an emergency room visit or after hospitalization. no study until now has investigated the existence of factors directly predictive of robustness. then the goal of this study is to demonstrate that there are robustness predictive factors after going to the emergency room.

Eligibility criteria:
inclusion criteria: * patients admitted to the emergency room * patients aged ≥ 75 years old * patients without cognitive disorders or vigilance disorders * patients living at home * patients able to give its non-opposition non inclusion criteria: * patients admitted to the hospital in the last 3 months * patients refusing to participate in the study exclusion criteria: * patients whose stay is \ 48h * patients who die during hospitalization * patient not hospitalized * patient not returning home after discharge from hospital

Keywords: elderly dependence emergency room visits lack of autonomy robustness re-hospitalization
effects of gua sha and thermotherapy on chronic neck pain

Conditions: Neck Pain

Summary: gua sha massage is a traditional chinese medical treatment. it is mostly used in the treatment of the common cold and pain syndromes. gua sha involves pressuring the skin by a round-edged instrument until small petechiae appear. this so called "sha", considered as the removal of blood stasis by traditional practitioners, will fade within a few days. normally, this treatment is not considered as painful, but as relaxing and easing tense muscles. in this study, the investigators will investigate the effectivity of gua sha massage in treating chronic neck pain. the investigators will research effects on subjective pain intensity, neck pain specific disability and haptic perception.


Eligibility criteria:
inclusion criteria: * chronic mechanical neck pain, at least 40 mm on a 100mm visual analog scale. * pain for at least 3 months. exclusion criteria: * radicular symptoms * congenital spine deformity * pregnancy * rheumatic diseases * oncologic diseases * other severe psychiatric or somatic comorbidity * recent invasive or surgical treatment of the spine * participation in other studies * skin diseases in the area to be treated

Keywords: neck pain massage hyperthermia, induced touch perception randomized controlled trial
improved screening for osteoporosis

Conditions: Osteoporosis

Summary: osteoporosis is a disease characterized by skeletal fragility due to decreased bone mass and deterioration of bone microarchitecture , leading to increased fracture risk for low trauma, such as spinal fractures or femoral neck . it is estimated that 3 million people are living in france , particularly women , with an incidence that increases with age . this disease is a major public health issue in terms of morbidity and mortality , costs and risk of recurrence (after a first fracture episode) , including risk factors are identified. however, although bone densitometry is a reliable diagnostic tool and preventive treatments are at our disposal, screening for osteoporosis is still insufficient . the objective of our study is to improve the detection of osteoporosis in hospital departmental vendee , using a simple questionnaire seeking risk factors followed by bone densitometry or if risk factors are found. based on the results , the patient will be sent in rheumatology consultation for implementation of treatment if necessary . therefore included women hospitalized in medical services , gynecology, surgery and orthopedics hospital departmental vendee , aged 50 to 80 years. will not be included women who could answer a simple questionnaire and those previously treated for osteoporosis or have already received a bone density there is less than 3 years old .


Eligibility criteria:
inclusion criteria: * women between 50 and 80 years * hospitalized * in health services, orthopedics, gynecology, surgery * able to respond to an easy questionnaire * able to give their agreement to participate in the study exclusion criteria: * patients with dementia * patients can not express * patients at end of life * patients previously treated for osteoporosis or recent densitometry (bmd) \<3 years * patients could not be seen in time by the nurse during their hospitalization * patients receiving a measure of legal protection
right ventricular function and pulmonary hypertension in hfpef

Conditions: Heart Failure With Preserved Ejection Fraction

Summary: in patients with heart failure and preserved ejection fraction (hfpef) right ventricular (rv) systolic and diastolic dysfunction are prognostically and functionally relevant factors but have mechanistically been neglected so far. in the present study alterations of intrinsic rv (systolic and diastolic) function, as assessed by invasive pressure volume loops, are examined in relation to tissue alterations on myocardial level and to the degree of rv afterload (pulmonary hypertension). study aim is to gain insights into mechanisms contributing to the development of rv dysfunction and potentially identify new therapeutic targets.


Eligibility criteria:
hfpef inclusion criteria: * clinical signs of heart failure * preserved left ventricular (lv) ejection fraction (ef \>= 50%) * structural heart diseases on echocardiogram/ n terminal-pro-brain natriuretic peptide \> 125ng/l * elevated lv end-diastolic pressure at rest (\>15mmhg) or during exertion (\>=25mmhg) no heart failure inclusion criteria: * no signs of heart failure * preserved left ventricular (lv) ejection fraction (ef \>= 50%) * normal lv end-diastolic pressure at rest (=\<15mmhg) and during exertion (\<25mmhg) exclusion criteria: * significant coronary artery stenosis at time of catheterization * acute coronary syndrome or cerebral insult within 1 month of examination * more than moderate valvular diseases * pregnancy * contraindication to cardiac magnetic resonance imaging
examining the effect of mental health disorders on vascular function and exercise tolerance

Conditions: Mental Health Disorders

Summary: specific aim #1: examining the impact of mental health disorders (ptsd and gad) on peripheral vascular function and sympathetic nervous system activity in young individuals. specific aim #2: examining the impact of mental health disorders (ptsd and gad) on peripheral hemodynamics and metabolic byproducts during small muscle mass exercise in young individuals. specific aim #3: examining the impact of mental health disorders (ptsd and gad) on exercise tolerance, peripheral hemodynamics and metabolic byproducts during large muscle mass exercise in young individuals.

mental health disorders are highly prevalent and underdiagnosed and can cause perturbations in cardiovascular and metabolic function leading to substantial individual burden (increased health care cost, loss of work productivity). post-traumatic stress disorder (ptsd) and generalized anxiety disorder (gad), two common mental health disorders, can cause increase cardiovascular disease risk due to chronic increases or fluctuations in heart rate, blood pressure, stress hormones, inflammation, and oxidative stress. post-traumatic stress disorder (ptsd) is a disabling psychiatric condition characterized by a persistent maladaptive reaction resulting from exposure to severe psychological stress. it has been revealed that individuals with ptsd, in addition to adverse mental health symptoms, also possess higher prevalence rates for physical comorbidities such as hypertension, obesity, diabetes, and metabolic syndrome. taken together, these ptsd-induced comorbidities result in a significant increase in the likelihood of developing cardiovascular disease (cvd) when compared to individuals without ptsd. anxiety disorders, the most prevalent mental health issue in the united states, is associated an increased incidence of hypertension and heart disease. this increased cardiovascular disease (cvd) risk is thought to derive from an overactivation of the sympathetic nervous system that results in a predominately pro-oxidant, pro-inflammatory cardiovascular environment. peripheral vascular dysfunction, or the inability of the blood vessels to adequately respond to specific stimuli, is a factor closely related to cvd. therefore, this study will focus on a younger population with ptsd or gad in an attempt to ascertain the presence of peripheral vascular dysfunction and the magnitude to which two potential primary contributors (autonomic dysfunction, oxidative stress) are involved in this dysfunction.

Eligibility criteria:
inclusion criteria: * apparently healthy and free of overt cardiovascular, pulmonary, or metabolic disease * for ptsd group, a score of ≥ 33 on pcl-5 checklist * for gad group, a score of ≥ 10 on the gad-7 self-report scale exclusion criteria: * taking medications that could influence cardiovascular function * limited english proficiency

Keywords: cardiovascular disease vascular function ptsd gad
cognitive rehabilitation in alzheimer's disease

Conditions: Alzheimer's Disease

Summary: this study aims to proof the efficacy of a cognitive rehabilitation program for patients with mild dementia in alzheimers disease with respect to activities of daily living.

this prospective randomized, single blind intervention study aims to proof a cognitive rehabilitation program for patients with mild dementia in alzheimers disease (ad). the investigators modified a manualized and established german behavioural therapy program (kordial) to use in a group context. the respective modules contain multimodal and multiprofessional approaches to improve capabilities relevant to activities of daily living (external memory support, compensation strategies, training of everyday competence, communication training). the intervention group receives this therapy for 12 weeks. age and gender matched participants with ad serve as active control sample receiving a standardized cognitive training in the domesticity. the primary outcome are measurements of skills in activities of daily living prior the intervention as well as at the end of the intervention (after 3 months) and after 6 months (follow up).

Eligibility criteria:
inclusion criteria: * mild dementia in alzheimer's disease (nincds-adrda) * mini mental state ≥ 17 exclusion criteria: * severe psychiatric disorder * severe brain disorder (epilepsy, tumor, stroke) * contraindication for mri examination
naltrexone in treatment of cocaine dependence - 5

Conditions: Cocaine-Related Disorders

Summary: the purpose of this study is to determine the efficacy of naltrexone in the treatment of cocaine dependence as measured by: 1) decreased urine benzoylecgonine (be) levels, 2) decreased cocaine use by self-report, 3) decreased cocaine craving, and 4) retention in treatment.

double-blind, placebo controlled study of the safety and efficacy of naltrexone in treating cocaine dependence in a patient sample that initiated the study while in an inpatient setting and were then followed-up for 3 months as outpatients.

Eligibility criteria:
inclusion criteria: 1. meet dsm-iii-r criteria for cocaine dependency, 2. 18 to 65 years of age, 3. capable of understanding the study, 4. voluntarily signed consent, 5. male or non-pregnant female using approved form of birth control. exclusion criteria: 1. abnormal liver function tests (sgot, sgpt, or ggt greater than twice the normal values), 2. opioid use within the last 7 days, 3. use of neuroleptics, 4. having a severe acute medical problem, 5. unable to complete psychiatric rating scales, or 6. judged by the investigator to be unlikely to comply with the study protocol

Keywords: cocaine dependence
safety of monthly recombinant factor xiii replacement therapy in subjects with congenital factor xiii deficiency: an extension to trial f13cd-1725

Conditions: Congenital Bleeding Disorder; Congenital FXIII Deficiency

Summary: this trial is conducted in asia, europe and north america. the aim of the trial is to investigate the safety of monthly replacement therapy of recombinant factor xiii in patients with congenital fxiii deficiency. the trial continues until the product is commercially available, but an interim assessment will take place when all subjects have completed 52 weeks in the trial.


Eligibility criteria:
inclusion criteria: * for subjects who participated in f13cd-1725: * previous participation (means up to and inclusive visit 16, (end of trial)) in f13cd-1725 * for all other subjects: * diagnosis of congenital fxiii a-subunit deficiency (confirmed by genotyping at screening visit or documented results from previously performed genotyping) * body weight at least 20 kg exclusion criteria: * known neutralizing antibodies (inhibitors) towards fxiii * any known congenital or acquired coagulation disorder other than congenital fxiii deficiency * platelet count (thrombocytes) of less than 50 × 109/l. for subjects who participated in f13cd-1725 platelet count from visit 15 in f13cd-1725 must be used for evaluation. * females of childbearing potential who are pregnant, breastfeeding or are not using adequate contraceptive methods
a study to evaluate the safety and effectiveness of rivaroxaban (xarelto) for prevention of stroke and systemic embolism in indian patients with non-valvular atrial fibrillation (nvaf)

Conditions: Non-valvular Atrial Fibrillation (NVAF)

Summary: this study is planned to collect prospective data and evaluate the safety and effectiveness of rivaroxaban for the prevention of stroke and systemic embolism in indian patients with nvaf when used in clinical practice under real-life conditions. the study will be conducted in routine clinical practice settings. approximately 1000 patients from india will be enrolled in this study. patients will be observed for maximum period of 12 months after the start of xarelto treatment or until it is no longer possible (e.g. lost to follow-up, death, withdrawal) before the end of the observation period. the decision by the investigator to start with of xarelto must be independent of the inclusion of a patient to the study.


Eligibility criteria:
inclusion criteria: * patient should be an adult female or male, ≥18 years of age; * patient should be diagnosed with nvaf and initiated with rivaroxaban treatment for prevention of stroke or systemic embolism per investigator's routine treatment practice; * patient should not have received rivaroxaban in the past; * patient/patient's legally acceptable representative should be willing to provide written informed consent. exclusion criteria: * patient has contraindications to receive rivaroxaban therapy according to local prescribing information; * patient is receiving anticoagulant therapy for indication other than nvaf and that needs to be continued as per discretion of treating physician; * patient is participating in an investigational program with interventions outside of routine clinical practice.

Keywords: stroke; systemic embolism
stop, focus, plan, and change: predicting parent and child responses to a brief, telehealth parent training

Conditions: Behavioral Problem; Irritable Mood; Parenting; Stress

Summary: this study will look at who does not improve after doing a behavioral parent training program briefly through telehealth. it will also study ways to make the intervention better for those that do not improve.


Eligibility criteria:
inclusion criteria: * parent speaks english or spanish * parent has access to internet * parent intends to complete treatment * parent reports child has elevated externalizing concerns exclusion criteria: * child is a ward of the state * child diagnosed with severe medical or nonverbal developmental disability

Keywords: behavioral concerns irritability parenting stress parenting practices
fixed low-dose heparin versus standard adjusted-dose heparin infusion in adults receiving venovenous ecmo with a heparin bonded circuit.

Conditions: Acute Respiratory Failure; Extracorporeal Membrane Oxygenation Complication; Bleeding

Summary: heparin is a blood thinner used to prevent blood clots in patients on a form of life-support called ecmo. heparin can cause bleeding - the most common complication of ecmo. new materials used in ecmo machines may help prevent clots - this could allow the use of lower doses of heparin which might reduce the risk of bleeding. our study will compare low dose to high dose heparin in patients on ecmo. we think low dose heparin may be adequate to prevent clotting, but may cause less bleeding and be safer for patients.

intravenous heparin is considered standard therapy to prevent clotting complications in patients on ecmo, however the optimal method of heparin dosing has not yet been determined. international surveys have shown that most ecmo centers use adjusted dose heparin to achieve an activated clotting time of at least 180 seconds. however, heparin may contribute to the most common complication of ecmo - bleeding. advances in material technology have potentially reduced the thrombogenicity of modern ecmo circuits. our observational data suggest that fixed low dose heparin infusion may reduce the rate of bleeding complications from 75% to 50% compared to standard adjusted-dose heparin, without increasing clotting complications. we intend to perform a randomized controlled trial in adults receiving venovenous ecmo comparing these two heparin regimens. the main outcome measures are bleeding complications and oxygenator failure due to clotting. a safety committee will monitor the results of the study. power calculations indicate a sample size of 110 patients is required, which we estimate will take us five years to achieve.

Eligibility criteria:
inclusion criteria: * on ecmo for acute respiratory failure, achieving ecmo blood flow rate \>3l/min, * patient or surrogate able to speak/understand english or spanish exclusion criteria: * history of heparin-induced thrombocytopenia, decision by clinicians to run ecmo off heparin due to high bleeding risk, * pregnancy

Keywords: extracorporeal membrane oxygenation intravenous heparin
evaluation of an icu-specific questionnaire for patient-reported outcome measures

Conditions: Intensive Care Unit Syndrome

Summary: an icu-specific questionnaire for patient reported outcome measures (prom) after critical care will be tested in a study of 650 patients recruited six months to three years after discharge from the icu, and 150 controls who have not been critically ill, matched for age and sex. the questionnaire is sent by mail after an invitation letter followed by a phone call and returned in a pre-stamped envelope. it is then scanned and data imported digitally. medical data from the icu-stay can be added. further analyses after comparison with the control population and item reduction will follow.

icu-patients were interviewed in a semi-structured way, providing detailed information on symptoms and difficulties in all areas of everyday life. the interviews were recorded, transcribed, and the issues were categorized into 13 hypothesised domains.all issues were then rephrased into questions, with care taken to maintain only one issue per question, and adequate scales for frequency, intensity and duration was used. the time frame is usually the last month. this intensive care specific questionnaire for patient reported outcome measures (prom) after critical care will be tested in a study of 650 patients recruited six months to three years after discharge from the icu, and 150 controls who have not been critically ill, matched for age and sex. the questionnaire is sent by mail after an invitation letter followed by a phone call and returned in a pre-stamped envelope. it is then scanned and data imported digitally. medical data from the icu-stay can be added. further analyses after comparison with the control population and item reduction will follow.

Eligibility criteria:
inclusion criteria: * patients treated in an intensive care unit at sahlgrenska university for more than 72 hours and survived are included between 6 months and tre years after discharge from icu. * control persons from the swedish population registry matched for sex and gender are also included. exclusion criteria: * patient with acute neurological/neurosurgical conditions and/or anoxic/hypoxic brain damage