eating concerns and compulsivity

Conditions: Anorexia Nervosa in Remission; Eating Disorder

Summary: this study uses a computational task to examine differences in adaptive learning to both rewards and punishments between three groups: those who have recovered from anorexia nervosa, those who score highly on the eat-26 (eating attitudes test - 26 item version; an eating disorder symptom scale), and healthy controls. this task also allows the examination of pupil response (thought to reflect norepinephrine activity) in response to expected and unexpected wins and losses.

this study involves using a novel computational task (the volatility task, designed by dr michael browning) to examine differences in adaptive learning in terms of sensitivity to environmental change in those who are in eating disorder 'risk' groups (defined as those with a previous diagnosis of an, and those who score highly in the eat-26 for eating disorder symptoms. this study allows us to investigate whether or not these individuals are able to pick up key environmental statistics and adapt their behaviour accordingly. we hypothesise that those in eating disorder risk groups will show a deficit in this area, which might begin to explain why the cognitive phenotype of 'cognitive inflexibility' is found so commonly in these patients. using pupillometry measures will also allow us to putatively form links between this behaviour and the norepinephrine system in these participants, as pupil dilation measures are thought to track environmental statistics of this kind. additionally, this task allows us to identify whether there is a particular deficit in tracking and learning about positive or negative environmental information. we will be using standard clinical interviews and questionnaires to define the groups and to record key variables (e.g. mood information) within groups. this study will consist of a single visit, including these interviews and questionnaires, the volatility task with pupillometry measures, and the wisconsin card sort task, which we hope to use to demonstrate a baseline difference between groups on cognitive flexibility.

Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the study. * females aged 18 to 45 years. * bmi over 18.5 and has remained so for the last year. * participant is a fluent english speaker. inclusion: recovered from anorexia * past formal diagnosis of an (defined by dsm-5 criteria). * fully recovered: score must be below 2.767 on the ede-q, below 16 on the cia, and below 20 on the eat-26 or partially recovered: scores may be above 2.767, 16 and 20 respectively. inclusion: high scoring on eat-26 * score above 20 on the eat-26 questionnaire. inclusion: healthy control * score below 2.767 on the ede-q, below 16 on the cia, and below 20 on the eat-26. exclusion criteria: * any current diagnosis of a psychiatric disorder which in the investigator's opinion could impact study results (e.g. significant depression, anxiety or ocd). * any current psychotropic medications. * current regular cigarette smoking of over 5 cigarettes per day. * recent use of illicit drugs. * alcohol intake which indicates an element of alcohol abuse; or unwillingness to refrain from drinking the night before the study visit. exclusion for high scoring eat-26 • a former formal diagnosis of an eating disorder. note that in this group a current diagnosis of ednos will not be an exclusion criterion.

Keywords: computational