Kornimate/medical-research-clean huggingface dataset:
the efficacy of balance and proprioception exercises in patients with knee osteoarthritis

Conditions: Knee Osteoarthritis; Balance; Distorted; Proprioceptive Disorders

Summary: this study aime to investigate the effects of balance and proprioception exercises using two different methods (classical balance training and balance system™ sd) in addition to strengthening exercises on dynamic balance, pain, functional status and quality of life in patients with knee osteoarthritis (oa).

it is known that knee oa leads to a decrease in proprioception and balance disturbances. falls due to balance disorders often occur during dynamic activities such as walking and stair climbing. therefore, correction of balance disorders is of great importance to prevent falls and associated fractures in the elderly population, in which knee oa is common. in addition, loss of proprioception in the knee joint, muscle weakness, and balance disorders are also known to contribute to the development of knee oa itself. therefore, treatment of balance disorders may also slow the progression of the disease. this study was planned to compare the effects of isometric strengthening exercises plus balance and proprioception exercises performed by two different methods with isometric strengthening exercises alone. this is a single-center randomized trial with 3 parallel arms.

Eligibility criteria:
inclusion criteria: * patients were included if they had a knee oa diagnosis according to the american college of rheumatology (acr) diagnostic criteria, had suffered from knee pain for at least six months, had radiologically verified bilateral knee oa of grade ii or iii according to the kellgren-lawrence classification and had not previously participated in a regular exercise program. exclusion criteria: * patients who had undergone knee surgery, who had received hyaluronic acid or corticosteroid injections into the knee within six months, and patients with conditions that might affect balance were excluded from the study.
the cognitive resilience study

Conditions: Alzheimer Disease

Summary: the purpose of this study is to test whether two new cognitive "stress tests" may help distinguish between people at lower or higher genetic risk of alzheimer's disease. the investigators are trying to understand how these cognitive "stress tests" work in people who have not been diagnosed with alzheimer's disease and are not exhibiting symptoms of alzheimer's disease. study subjects will undergo testing of memory and executive function during functional magnetic resonance image (fmri) of the brain and also during a walking test.

the objective is to establish the feasibility and evaluate the role of two novel tests of cognitive resilience for use in identification of early alzheimer's disease. the investigators hypothesize that exposure to the controlled stressor of increased cognitive task demand will evoke measurable phenotypes of poor resilience, which will be associated with alzheimer's disease risk. the study will include 30 volunteer participants from the duke alzheimer's disease prevention registry (adpr). the adpr cohort has been characterized according to genetic risk based on genotype at loci associated with alzheimer's disease. the investigators will recruit a sample from the adpr that includes 15 people in the "genetic high risk" group and 15 people, matched by age, in the "genetic low risk" group. investigators and experimenters are masked to the genetic profile of all participants. all participants will undergo two cognitive stress test protocols. both protocols include memory and executive function components, one done during functional mri and one while ambulating on a force sensor mat. both cognitive stress tests are minimal risk; the primary risk of this study is loss of confidentiality. genetic testing is not performed as part of this protocol; the sampling strategy will make use of prior genetic testing results, which are not revealed to the primary investigators. in addition to determining whether scores on the two novel tests statistically differ by ad risk groups, the project will establish the tests' feasibility and characteristics for use in future study.

Eligibility criteria:
inclusion criteria: * able to walk 2 minutes without assistive device or assistance from another person * cognitive function within normal limits exclusion criteria: * unable to undergo mri * left handed * red/green color blind * severe vision impairments * diagnosis of alzheimer's disease or other dementia/memory problem
treatment effect of edaravone in patients with amyotrophic lateral sclerosis (als)

Conditions: Neuromuscular Diseases

Summary: amyotrophic lateral sclerosis (als) is a neurodegenerative disease that causes the death of 30,000 affected individual every year. complex nature and unknown pathogenesis of this disease are 2 major reasons for failure of therapeutic interventions. edaravone is a free radical scavenger that slows down functional decline and prevents from disease progression in als patients. fda newly approved this drug in these patients (2017/5/5). in this study, investigators aimed to assess the treatment effect of this newly approved drug in patients with als in a representative iranian population.


Eligibility criteria:
inclusion criteria: 1. patients diagnosed as definite or probable als according to el escorial criteria. 2. als patients who are graded as mild or moderate according to als health state scale. 3. forced vital capacity of at least 80% 4. desire of the patient to participate in this study and signing written informed consent. exclusion criteria: 1. incidence of drug's side effects that requires discontinuation of the drug (edaravone's side effects: acute kidney injury, acute allergic reactions, dic, thrombocytopenia, leukopenia). 2. desire of the patient to discontinue participating in this study. 3. the patient starts another drug or herb for als during the study.

Keywords: amyotrophic lateral sclerosis edaravone
educational intervention to reduce drug-related hospitalizations in elderly primary health care patients

Conditions: Polypharmacy; Adverse Drug Reaction

Summary: the purpose of this study is to determine whether an educational intervention given towards health care providers working in primary health care centers can reduce inappropriate prescribing in the elderly patient and thus reduce number and length of drug-related hospitalizations as well as number of emergency department visits in this patient group.

inappropriate medication in the elderly patient leads to substantial morbidity, possibly causing up to 20% of hospitalizations in this patient group (1). to improve prescribing and thus reduce undesired drug effects is a great challenge for doctors and nurses in primary health care. performance of drug utilization reviews is recommended in order to reduce the negative impact of inappropriate prescribing in the elderly. however, scientific evidence on their efficacy is lacking, especially regarding patient-related health outcomes (2,3). most studies are carried out in inpatient care, making it difficult to draw conclusions regarding primary health care (2). moreover, studies in this scientific field diverge regarding the content and structure of drug utilization reviews, which implies that comparison between studies becomes challenging, if not impossible. this trial aims at educating health care providers in how to perform drug utilization reviews, and to help them implement theory into practice.

Eligibility criteria:
inclusion criteria: * primary health care center in stockholm county * authorized by stockholm county council since at least 3 years * at least 5% of patients attributed to primary health care center are 65 years and older * primary health care center takes care of at least 10 home care patients exclusion criteria: * less than 3000 patients listed in primary health care center * primary health care centers where researchers carrying out the present study work

Keywords: drug utilization review aged aged, 80 and over primary health care
dynamic mediterranean prospective cohort: the sun project

Conditions: Lifestyle; Chronic Disease; Dietary Habits

Summary: dynamic prospective cohort of spanish university graduates. the main objective is to evaluate the associations between nutrition and lifestyle and chronic diseases.

the sun project (university of navarra follow-up study) began in 1999, and currently more than 20,500 people participate. the project is permanently open to new volunteers, and around 2,000 new participants are invited each year. a new questionnaire is sent to participants every two years. the questionnaires are named with the letter "q," followed by the number of years that have passed since the participant first volunteered. the first questionnaire is titled "q0" and is followed by "q2","q4", etc. the cohort is "dynamic" thanks to the fact that it is permanently open to new volunteers. although the project was created by the department of preventive medicine and public health of the university of navarra, it now counts on the invaluable collaboration of other spanish university centers. thanks to the invaluable collaboration of our participants, the investigators are able to research cardiovascular diseases, depression, fertility, arterial hypertension, and car accident injuries, among other areas.

Eligibility criteria:
inclusion criteria: * spanish university graduates exclusion criteria: * not spanish university graduates

Keywords: nutritional epidemiology prospective
prospective clinical trial of the lensar laser system

Conditions: Cataract

Summary: the lensar laser system is used to create an opening in the anterior capsule of the lens and fragments the cataractous lens. the study will evaluate clinical outcomes compared to the contra-lateral eye treated with conventional phacoemulsification surgery.


Eligibility criteria:
inclusion criteria: * subjects must sign and be given a copy of the written informed consent form * subjects must have elected to undergo lens extraction and iol implantation and then elect to have the lensar laser surgery as part of the procedure. * subjects must be willing and able to return for scheduled follow-up examinations for 6 months after surgery. * subjects must have central 7 mm of clear cornea without vascularization. exclusion criteria: * subjects who have undergone previous corneal or intraocular surgery in the eye to be treated. * subjects with a history, signs or symptoms of ocular disease or atypical finding which would be contraindicated under standard of care for cataract surgery. * diabetic or hypertensive subjects with clinical evidence of retinal pathology. * subjects with macular degenerative pathology. * subjects with a history of steroid-responsive rise in iop or uncontrolled glaucoma in either eye. * subjects with known lens/zonular instability such as, but not restricted to, marfan's syndrome, pseudoexfoliation syndrome, etc. * subjects with corneal disease or pathology that precludes applanation of the cornea or transmission of laser wavelength or distortion of laser light.

Keywords: cataract capsulotomy capsulorrhexis lens fragmentation phacoemulsification
ivosidenib in locally advanced or metastatic cholangiocarcinoma with idh1 r132 mutation after at least one prior systemic treatment - an observational study

Conditions: Cholangiocarcinoma

Summary: cholangiocarcinoma is a rare and aggressive tumor of the bile duct associated with a poor prognosis and very limited treatment options. the idh1 inhibitor ivosidenib provides a new, targeted treatment option for this disease. ivosidenib was approved by european medicines agency (ema) in may 2023 as monotherapy in adult patients with locally advanced or metastatic cholangiocarcinoma with an idh1 r132 mutation who were previously treated by at least one prior line of systemic therapy. the prospective, multicenter, observational study idhira will collect first real-world data on ivosidenib treatment in a broad patient population in germany. ivosidenib will be administered according to the current smpc. thus, idhira will generate real-world evidence on effectiveness, quality of life (qol) and safety of ivosidenib.


Eligibility criteria:
inclusion criteria: * age 18 years or older. * histologically confirmed locally advanced or metastatic ccc with a documented idh1 r132 mutation diagnosed by an appropriate diagnostic test * patients must have at least one prior systemic therapy * decision for treatment with ivosidenib according to current smpc. * signed written informed consent before or within 6 weeks of first ivosidenib dose (inclusion of patients up to 6 weeks after first ivosidenib intake is allowed for patients not participating in the pro module) * for patients participating in the pro module (optional): * dated signature of informed consent form before start of study treatment. * willingness and capability to participate in pro assessment in german language. * other criteria according to current smpc. exclusion criteria: * participation in an interventional clinical trial within 30 days prior to enrolment or concurrent participation in an interventional clinical trial except for the follow-up period. * other contraindications according to current smpc.
exercise in air pollution and lung health in asthmatics

Conditions: Exercise-induced Bronchoconstriction; Air Pollution

Summary: when exposed to air pollution, the asthma symptoms are aggravated and lung function is impaired. due to high breathing rates and volumes, physically active individuals are at particular risk of lung health impairment due to the high breathing rates and volumes. greater doses of air pollutants reach deeper areas in the lungs where they can trigger asthma-symptoms. when treating these symptoms with inhaled beta-2-agonists the airways widen even more, allowing the air pollutants to reach even deeper areas of the lung. with this study the investigators investigate how inhaled beta-2-agonists affect athletic capacity and lung health in physically active asthmatics.


Eligibility criteria:
inclusion criteria: * mild-moderate asthmatics with controlled treatment (definition of "mild": percent fall index at eucapnic voluntary hyperpnea (evh) test on screening day between 10-15%; "moderate": percent fall index at evh test on screening day between 15 - 20%). * men and non-pregnant women exclusion criteria: * any history of uncontrolled respiratory or cardiac disease * pregnancy * allergic reactions to lidocaine and salbutamol * any recent infections or orthopaedic nasal issues/injuries that may interfere with the insertion of the catheter needed to assess expiratory flow limitation or work of breathing * claustrophobia in small rooms, comparable to the air pollution chamber used for this study. * english as a second language (esl) - participants who are not able to understand the risk that may be associated with the participation in this study due to language difficulties after following the university of british clinical research ethics board guidance notes 13.2.1. (esl participants will be given a consent form in the most appropriate language or an appropriate translator will be present during the initial consent process).

Keywords: exercise-induced bronchoconstriction air pollution exercise inhaled beta-2-agonist cognitive function
influence of biial following pph on dorsal clitoral artery blood flow and fsfi

Conditions: Bilateral Iliac Artery Ligation; Postpartum Hemorrhage

Summary: dorsal clitoral artery doppler examinations in women with bilateral internal iliac artery ligation due to postpartum hemorrhage (study group) and age-matched healthy puerperal women were performed regularly in the postoperative period, in order to evaluate possible effects of biial on clitoral blood flow.

women who underwent bilateral internal iliac artery ligation due to postpartum hemorrhage in gaziantep cengiz gokcek maternity hospital, gaziantep turkey and near east university, department of obstetrics and gynecology, mersin, turkey comprise the study group. the control group consists of age-matched healthy women who delivered in last 2 months. dorsal clitoral artery doppler examinations will be performed in both case and control groups regularly in the postoperative period in 3rd and 6th months, in order to evaluate the possible effects of biial on clitoral blood flow. ultrasound is performed using a mindray dc-7 ultrasound system (china) equipped with linear 7.5 mhz probe. each woman was scanned in the gynecological position. the translabial probe is placed on the clitoris sagittally and transversely without applying any pressure force. after identifying the clitoral artery using colour flow mapping, the doppler probe is positioned over the vessel and at least three sequential doppler wave forms are obtained. the following parameters are analysed: peak systolic velocity (psv), end diastolic velocity (edv), resistive index (ri), pulsatile index (pi) and systolic/diastolic (s/d) ratio. the measurements are performed by the same radiologist. finally a female sexual fantasy questionnaire (fsfq) is performed.

Eligibility criteria:
inclusion criteria: * 18-35 year-old women who underwent bilateral internal iliac artery ligation (biial) due to postpartum hemorrhage * age-matched healthy puerperal women exclusion criteria: * known diabetes melitus or cardiovascular disease * known affection disorder before or during pregnancy * b-lynch procedure, ligation of uterine or ovarian artery, hysterectomy and salphingooophorectomy following postpartum hemorrhage * known functional sexual disorder before pregnancy * postoperative endometritis or other puerperal infections * postoperative thromboembolic incidence * cessation of breastfeeding in puerperal period

Keywords: ultrasonography, doppler, color postpartum hemorrhage bilateral iliac artery ligation dorsal clitoral artery
effect of roflumilast on exacerbation rate in patients with chronic obstructive pulmonary disease (copd): the aura study (by217/m2-124)

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: the aim of the study is to investigate the effect of roflumilast on exacerbation rate and pulmonary function in patients with chronic obstructive pulmonary disease (copd). roflumilast will be administered orally once daily in the morning at one dose level. the study duration will last up to 56 weeks. the study will provide further data on safety and tolerability of roflumilast. for additional information (for us patients only) see www.copdstudy.net or dial 866-788-2673 (toll free).


Eligibility criteria:
main inclusion criteria: * copd patients having at least one exacerbation within last year * fev1/fvc ratio (post-bronchodilator) ≤ 70% * fev1 (post-bronchodilator) ≤ 50% of predicted main exclusion criteria: * copd exacerbation not resolved at first baseline visit * diagnosis of asthma and/or other relevant lung disease

Keywords: roflumilast copd chronic obstructive pulmonary disease
delineation of reducing clinical target volume for early-stage nasopharyngeal carcinoma patients

Conditions: Target Volume Delineation; Early-stage Nasopharyngeal Carcinoma; Intensity Modulated Radiation Therapy

Summary: to analyze the long-term results and toxicities of the reducing clinical target volume (ctv) delineation method in early-stage nasopharyngeal carcinoma (npc) patients treated with intensity modulated radiation therapy (imrt).

the investigators designed a prospective phase ii study for early-stage npc patients, and proposed a reasonable delineation method of reducing ctv according to the clinical characteristics and tumor infiltration patterns, performing therapeutic dose to tumor and prophylactic dose to ctv while protecting as much normal tissues as possible, in order to ensure a long-term survival with good quality of life.

Eligibility criteria:
inclusion criteria: 1. histologically confirmed npc (who ii-iii) 2. stage i-iib according to the 6th ajcc/uicc 3. no previous treatment for npc 4. between 18 and 70 years old 5. kps ≥ 80 scores 6. adequate organ function (white blood cell ≥ 4.0×109/l; absolute neutrophil count ≥ 1.5×109/l; hemoglobin ≥ 100g/l; platelet count ≥ 100×109/l; total bilirubin, aspartate aminotransferase and alanine aminotransferase ≤ 1.5x upper limit normal; and creatinine clearance rate ≥ 30 ml/min) exclusion criteria: 1. fine-needle aspiration biopsy, incisional or excisional biopsy of neck lymph node, or neck dissection prior imrt 2. disease progression during imrt 3. presence of distant metastasis 4. pregnancy or lactation 5. previous malignancy or other concomitant malignant disease

Keywords: locoregional failure pattern toxicity
comparison between fully covered metal stents and plastic stents in preoperative biliary drainage

Conditions: Periampullary Cancer; Complications of Surgical Procedures or Medical Care; Disorder of Bile Duct Stent

Summary: this study is a prospective, randomized study to compare of outcome of fully covered metal stents with that of plastic stents for preoperative biliary drainage in distal common bile duct cancer, pancreas head cancer or ampullary cancer with respect to the incidence of stent-related adverse events, the re-intervention rate, the effectiveness of biliary drainage, surgical outcomes and hospital stays.

pancreaticoduodenectomy is curative option in periampullary tumor. preoperative endoscopic retrograde cholangiopancreatog-raphy (ercp) is usually undertaken in patients with resectable disease to relieve biliary obstruction, which is thought to impair immune response, clotting, and other functions that impact intraoperative and postoperative outcomes. despite conflicting data pertaining to preoperative biliary drainage, ercp with biliary stenting has become standard practice in patients with periampullary malignancies. in a recent multicenter randomized trial, patients who underwent preoperative biliary drainage had a 74% rate of complications compared with 39% for those who directly underwent surgery without preoperative biliary drainage. in this trial, however, all patients underwent placement of plastic stents. in ercp, self-expandable metal stent are being increasingly placed for palliation of malignant biliary obstruction. compared with plastic stents, self-expandable metal stents have large caliber and have demonstrated longer patency duration. even in patients with resectable malignant disease, self-expandable metal stents which are placed below the level of transection may not impair technical outcomes at surgery and can be safely removed along with the surgical specimen. this prospective study is designed to compare the incidence of stent-related adverse events, the re-intervention rate, the effectiveness of biliary drainage, surgical outcomes and hospital stays in patients with periamupllary tumors who are undergone with self-expandable metal stents or plastic stents placement for preoperative biliary drainage

Eligibility criteria:
inclusion criteria: * older than 20 years old of age * obstructive jaundice due to common bile duct cancer and pancreas head cancer, or ampullary cancer * no evidence of distant metastases or locally advanced tumor exclusion criteria: * unresectable stage of cancer * preoperative gastric operation that preclude ercp (total gastrectomy and subtotal gastrectomy with b-ii anastomosis) * severe gastric outlet obstruction or duodenal obstruction * severe comorbidity (karnofsky\<50%)

Keywords: self-expandable metal stent; plastic stent