Kornimate/medical-research-clean huggingface dataset:
screening, early referral and lifestyle tailored e_prescription for cardiovascular prevention

Conditions: Cardiovascular Diseases; Cerebral Infarction; Type2 Diabetes Mellitus; Hypertension,Essential; Prevention

Summary: we will evaluate an e_prescription intervention can be integrated into an electronic screening program, which together exploit: (i) reach - the adult population has 100% mobile phone ownership and 92% internet national coverage; and (ii) behavioral change - the intervention can teach verbally and visually, thus bypassing literacy challenges, to allow simple, low-cost, repetition messaging for habit reinforcement. uptake of the program through the various stages will be evaluated in \~2000 adults of a large representative suburban district of karachi: as well as before-and-after physiological measures, including blood pressure (bp) and blood glucose, a random sample of 30-40 participants will be invited for interview to assess success and failure of the program. this is a pragmatic feasibility intervention implementation study.

the goal of this pilot study is to demonstrate feasibility of a scalable , population-wide, approach to early detection and management of people at high-risk of cvd using electronic screening, referral, treatment and lifestyle modification based on health theory and considerable background research for local applicability. it is a mixed method, feasibility study based in malir district of karachi, the largest city in pakistan, to demonstrate uptake, participation and response of our mhealth intervention.

Eligibility criteria:
inclusion criteria: * all adult (\>18 years) residents of malir district * own a mobile phone * provide written informed consent are eligible to participate exclusion criteria: * not permanent residents of malir district. * a person who is decision impaired due to stroke, or aphasia or dementia . * serious cognitive deficits that impair the visualization or understanding of sms, ivr and e_prescription messages

Keywords: mhealth mixed method feasibility study malir district
adductor-canal-blockade versus the femoral nerve block effect on muscle strength, pain and mobilization after total knee replacement

Conditions: Total Knee Arthroplasty

Summary: the aim of this study is to investigate the efficacy of the adductor-canal-blockade versus the femoral nerve block on muscle strength, pain and mobilization after total knee arthroplasty. we hypothesize that the adductor-canal-blockade has the same effect on pain and morphine consumption as the femoral nerve block, but without the same reduction in quadriceps muscle strength.


Eligibility criteria:
inclusion criteria: * asa 1-3 * bmi \> 18 og \< 40 * total knee arthroplasty in spinal anesthesia exclusion criteria: * can not cooperate to the exam * do not speak or understand danish * drug allergy * alcohol or drug abuse * daily consumption of strong opioids * rheumatoid arthritis * intake of glucocorticoids * effect of spinal anesthesia stopped prior to performing the regional block

Keywords: adductor-canal-blockade femoral nerve block postoperative pain total knee arthroplasty
an observational study of roactemra/actemra (tocilizumab) as monotherapy in rheumatoid arthritis patients in routine clinical practice

Conditions: Rheumatoid Arthritis

Summary: this prospective, multi-center, observational study will evaluate factors influencing the use of tocilizumab (roactemra/actemra) as monotherapy in rheumatoid arthritis patients in real life setting. data will be collected from participants for 12 months following initiation of tocilizumab treatment.


Eligibility criteria:
inclusion criteria: * adult participants, \>/= 18 years of age * patients with rheumatoid arthritis for whom the rheumatologist decides to start tocilizumab in combination with dmard or as monotherapy exclusion criteria: * current participation in a clinical trial in rheumatoid arthritis
study evaluating the correlation between c-11 acetate uptake and retention as measured by pet and fas in prostate cancer

Conditions: Prostate Cancer

Summary: the purpose of this study is to understand if a new type of radiology test called positron emission tomography (pet) with carbon 11 acetate will help us to understand which cancers produce more of a protein called fatty acid synthase (fas).

* within 4 weeks of the patient's scheduled surgery they will undergo a c11 acetate pet scan. this scan will be performed at the massachusetts general hospital's nuclear medicine department and involves an intravenous injection of acetate with a radioactive tracer followed by a pet scan. the scan will determine how well the tumor is taking up the acetate. * patients will also undergo a ct scan of the pelvis at the same time as the pet scan. * after surgery, the removed tumor will have additional testing that will look at different factors that may tell us how aggressive the tumor is and how much fas is within the tumor. fas seems to be produced in higher amounts by prostate cancer cells than normal cells. we will then try to determine if the results of the c11 acetate pet scan can tell us how much fas is produced by prostate cancer cells.

Eligibility criteria:
inclusion criteria: * histologically documented prostate cancer * planned radical prostatectomy * \> 50% cores positive for prostate cancer from prostate biopsy or a palpable prostate nodule * older than 18 years of age exclusion criteria: * inability to lay on a scanner for 60 minutes

Keywords: prostate cancer positron emission tomography carbon 11 acetate pet fatty acid synthase fas
meditation as complementary treatment for chronic hypertension in pregnancy

Conditions: Hypertension, Pregnancy-Induced; Hypertension in Pregnancy; Hypertension

Summary: pregnancy relates to arterial hypertension; it is an aggravating factor for pre-existing chronic arterial hypertension or a trigger for preeclampsia in normotensive women. the gestational hypertensive disease is managed conventionally with the pregnant woman's hospitalization and/or the use of antihypertensive medications. nevertheless, this treatment may present some risks. the investigators seek to determine whether the intervention compared to the control can reduce the increase in blood pressure that pregnant women in the transition from the 2nd to the 3rd trimester.

primary research question: can meditation decrease the mean increase in diastolic blood pressure in pregnant hypertensive women at the transition from the second to the third trimester of gestation? secondary research question: can meditation decrease the mean increase in systolic blood pressure in pregnant hypertensive women at the transition from the second to the third trimester of gestation? does meditation practice increases (or decreases) the likelihood of change in resilience indicators? does meditation practice increase (or decrease) the likelihood of change in anxiety and depression indicators? does meditation practice increase (or decrease) the likelihood of change in mindfulness indicators? does meditation practice increase (or decrease) the likelihood of change in quality of life indicators?

Eligibility criteria:
inclusion criteria: 1. pre-existing hypertension. 2. single pregnancy, with gestational age between 20th and 24th weeks, with uncomplicated systemic arterial hypertension. 3. prenatal follow-up in a high-risk pregnancy clinic. 4. no personal background of depression or psychiatric disorders. 5. no serious heart disease. 6. no illicit drugs and/or alcohol use. 7. acceptance of the informed consent. 8. to follow the practice used in the study, the subjects are required to have an available phone in order to download an app which contains an audio guide for this purpose. exclusion criteria: 1. diagnosis of depression and psychiatric disorders during pregnancy. 2. patients who do not return to follow-up or who want to quit the study. 3. to practice meditation.

Keywords: systemic arterial hypertension hypertension hypertension, pregnancy-induced pre-eclampsia meditation randomized clinical trial
treating amblyopia in adults with interactive video games

Conditions: Amblyopia

Summary: researchers are trying to determine whether interactive video game play, while wearing a patch over better-seeing eye, will improve subject reduced vision (amblyopia).

the purpose of this research is to determine whether amblyopia (reduced vision in one eye) in adults can be improved using interactive video game play. study participation involves playing the video game mario karttm (provided by the study), while wearing a patch over their better-seeing eye. participants are asked to play the game for a total of 40 hours over a one-month period. the primary outcome measure will be logmar visual acuity measured 1 month after initiating game play.

Eligibility criteria:
inclusion criteria: * aged \>17 years old * refraction within past year and wearing updated glasses or contact lenses * diagnosis of strabismic, anisometropic or combined amblyopia (\> 2 lines inter-ocular difference) * stable visual acuity as defined as \<1 logmar change over 2 visits 8 weeks apart, or wearing glasses for at least 16 weeks exclusion criteria: * monovision and unwilling to wear corrective glasses * allergy to adhesive bandages * women who are currently pregnant
comparison of quality of life in patients undergoing more intensive versus less intensive chemotherapy and radiation preceding a bone marrow transplant

Conditions: Bone Marrow Transplantation

Summary: this study will examine the quality of life of patients undergoing bone marrow transplantation to treat a blood disease. it will look at how this therapy affects many areas of life, including for example, personal relationships, work, and general emotional state. the information gained may lead to improved ways of dealing with problems that may arise before or during treatment. patients receiving bone marrow stem cells donated by a family member may participate in this study. they will be interviewed before treatment begins and will complete questionnaires at the following intervals: 1. day of admission to the hospital 2. day of the transplant 3. 30 days after the transplant 4. 100 days after the transplant 5. 1 year after therapy 6. 2 years after therapy all questionnaires to be completed after discharge from the hospital will be scheduled during a regular follow-up visit. each questionnaire takes about 15 to 20 minutes to complete. the information provided is confidential and will not be shared.

clinical research in blood stem cell and bone marrow transplantation documents improvements in disease free intervals, disease free survival, and the severity of treatment related toxicities. however, it is important for patients and families to know the quality of life (qol) they can expect following an allogeneic transplant. in this longitudinal study we will compare the qol of patients undergoing a non-myeloablative allogeneic peripheral blood stem cell transplant (a-pbsct) prospectively with that of a myeloablative a-pbsct. subjects (n=106) over the age of 18 will be enrolled. measures of quality of life (medical outcomes study short form-mos sf-36 and functional assessment of cancer therapy-general and bone marrow transplant - fact-g and fact-g/bmt) and symptom distress (symptom distress scale - sds) will be administered prior to transplant (baseline) and at set interval post transplant. data will be analyzed using repeated measures analysis of variance and regression analysis.

Eligibility criteria:
inclusion criteria: male or female subjects 18 years of age or older. able to read english or spanish. hematological disease requiring a-pbsct. signed informed consent for qol study.

Keywords: allogeneic transplant function mini-transplant physical symptoms symptom distress
evaluating the response of the immune system of people with long covid (post sars-cov-2)

Conditions: COVID-19

Summary: many people who have had covid 19 continue to experience symptoms long after they have recovered from the acute infection. this study will examine the clinical symptoms of people with "long covid" and measure various markers of inflammation in their blood.

patients who attend the long covid recovery clinic at huntington hospital will be offered participation in the study. after giving written informed consent, their medical history along with a description of clinical symptoms given through an extensive questionnaire will be accessed. venous blood will be collected as a baseline and then at follow up visits (as dictated by changes in clinical symptomatology) for evaluation of corollary immune parameters. patients will be followed at a minimum of every 2 months for 2 years.

Eligibility criteria:
inclusion criteria: * enrolled in huntington hospital\&#39;s long covid recovery clinic * documented previous infection with sars-cov2 * symptoms suggestive of post-acute sequelae of sars-cov2 (including but not limited to chronic fatigue, brain fog, muscle and joint pain, cardiac and pulmonary issues, or other factors related to their acute covid-19 event) * signed informed consent form exclusion criteria: * no documented positive sars-cov2 serologies * no post-acute sequelae of sars-cov2 symptomatology * incarcerated

Keywords: post-acute sequelae of sars-cov2 post-acute covid-19 syndrome long covid
a study to assess the safety and efficacy of ecf843 vs vehicle in subjects with dry eye disease

Conditions: Dry Eye

Summary: the study was planned to be conducted in 2 parts: part 1 to determine the efficacy and safety of ecf843 vs vehicle, followed by part 2 with additional exploratory assessments of ecf843 vs vehicle. both parts of the study included a double-masked study design, with randomization stratified for subjects with sjogren's syndrome.

part 1 of the study was a double-masked, randomized, parallel design in which participants were assigned to one of the following five treatment arms/groups in a ratio of 1:1:1:1:1. * ecf843 0.45 mg/ml three times daily (tid) or vehicle * ecf843 0.15 mg/ml tid or vehicle * ecf843 vehicle tid * ecf843 0.15 mg/ml twice daily (bid) or vehicle * ecf843 vehicle bid the planned duration of double-masked treatment during part 1 was 56 days. for subjects randomized to ecf843, the maximum drug exposure was up to 28 days. at some point during part 1, all participants received vehicle. the study was terminated after completion of part 1 and part 2 of the study was not therefore initiated.

Eligibility criteria:
inclusion criteria: * written informed consent must be obtained before any assessment * adult male or female subjects 18 years of age or older * at least 6 months history of dry eye disease in both eyes * must use, or feel the need to use, artificial tears/gels/lubricants on a regular basis * composite corneal fluorescein staining score \>= 4 (modified national eye institute (nei) scale) in at least one eye * schirmer score \>= 1 and =\< 10 mm after 5 minutes in at least one eye * patients with sjögren's syndrome must have dry eye exclusion criteria: * ocular infection in either eye within 30 days prior to screening * use of artificial tears, gels, lubricants within 4 hours of the screening visit * use of contact lenses in either eye within 14 days of screening * uncontrolled ocular rosacea * clinically significant conjunctivochalasis in either eye * other corneal conditions affecting the corneal structure * severe ocular conditions such as herpes, graft versus host disease, stephen's johnson syndrome, sarcoidosis * currently active, or history of ocular allergies during the time of year the patient will be participating in the study * patients with current punctal plugs or punctal cauterization or occlusion * chronic medications (both over the counter and prescription) that have not been stable for at least 30 days prior to screening. * use of restasis®, cequa®, or xiidra® within 30 days prior to screening * use of ocular, nasal, inhaled, or systemic corticosteroids within 30 days of screening * history of malignancy of any organ system within the past five years * pregnant or nursing women

Keywords: dry eye sjogrens dry eye syndrome (des) keratoconjunctivitis sicca (kcs) keratitis xerophthalmia sjögren's syndrome sjogren's syndrome
cervical pessary to prevent preterm birth in singleton pregnancies with a sonographically measured short cervix

Conditions: Premature Birth

Summary: the purpose of this study is to learn if the arabin pessary can reduce preterm birth less than 37 weeks 0 days in singleton pregnancies that have a short cervix.

this is an open label randomized controlled study. the pessary will be offered to those patients who have a transvaginal cervical length less than 25 mm before 23 weeks 0 days. the control group will receive the current standard of care which includes surveillance of cervical length, vaginal progesterone, and emergency cerclage. the primary outcome of the study is preterm delivery less than 37 weeks 0 days.

Eligibility criteria:
inclusion criteria: * singleton * cervical length \< 25 mm measured by transvaginal ultrasound prior to 23 weeks 0 days * agrees to refrain from sexual intercourse exclusion criteria: * major fetal anomalies * painful regular uterine contractions * active vaginal bleeding * ruptured membranes * evidence of chorioamnionitis or other maternal/fetal infectious morbidity * placenta previa * cervical cerclage in situ * visual cervical dilation of 2 cm or greater with visible amnion/chorion * significant maternal-fetal complications (chronic hypertension, insulin dependent diabetes mellitus, systemic lupus erythematosus with nephritis, chronic hypertension, red cell alloimmunization, drug abuse)

Keywords: arabin pessary short cervix
pulmonary rehabilitation implemented with vr for post-covid-19 patients

Conditions: COVID-19

Summary: although the covid-19 pandemic was announced almost 2 years ago, societies are still facing the effects not only of individuals but also of entire populations. clinical symptoms in patients depending on the variant of the virus range from fever, sore throat, cough, fatigue, or gastrointestinal or neurological symptoms. symptoms of respiratory failure also occur, as well as heart and kidney damage. therefore, it is important to implement appropriate pulmonary rehabilitation programs to counteract the effects of the disease. the current project aims to evaluate the effectiveness of a comprehensive pulmonary rehabilitation program for patients hospitalized for sars-cov2 infection.

initial studies indicated that approximately 60 days after the first covid-19 symptom onset, only 13% of patients previously hospitalized for covid-19 were reported to be essentially free of any covid-19-related symptoms, while 32% had one or two symptoms and 55% had three or more symptoms. furthermore, the covid-19 pandemic gives rise to new psychosocial and emotional stressors for recovering patients, including social isolation, physical distancing, loss of employment and uncertainties about the future. in the confrontation of such an uncertain prognosis, it seems justified to introduce preventive actions against the development of pandemic-related adverse effects. to date, only few publications assessed the effectiveness of early post-hospital rehabilitation of patients with covid-19. this project is aimed to propose an innovative comprehensive intervention based on a stationary pulmonary rehabilitation (pr) programme for covid-19 survivors. moreover, this project assumes the use of virtual reality (vr) in rehabilitation processes.

Eligibility criteria:
inclusion criteria: * individuals hospitalized for covid-19. exclusion criteria: * failure to consent to participate in research, * pneumonia, * evidence of ischemic heart disease/acute changes on ecg, * uncontrolled hypertension, * insulin dependent diabetes mellitus, * inability to exercise independently or musculoskeletal/neurological conditions that would prevent completion of the course, * lung cancer, * cognitive disorders, or mini-mental state examination \< 24.

Keywords: covid-19 pulmonary rehabilitation virtual reality
non-invasive diagnosis of pediatric pulmonary invasive mold infections

Conditions: Pulmonary Invasive Fungal Infections; Pulmonary Invasive Aspergillosis

Summary: this study will establish a non-invasive diagnostic approach and evaluate clinical outcomes for children at high-risk for pulmonary invasive fungal infection (pifi).


Eligibility criteria:
inclusion criteria: * males or females age \> 120 days and \< 22 years at any participating site * have at least one of the following conditions associated with a known high incidence of ifi: hematopoietic stem cell transplantation (hsct), aplastic anemia, bone marrow failure, primary or acquired immune deficiency, or malignancy * new (last 96 hours) radiographic evidence of at least one of the following: at least one nodular lesion greater than or equal to 5 mm in size, a wedge-shaped and segmental or lobar consolidation, a cavitary lesion, a lesion with a halo sign, a lesion with a reverse halo sign, or a lesion with an air crescent sign * prolonged neutropenia (absolute neutrophil count \< 500 cells/µl for a period of ≥ 5 consecutive days) in 30 days prior to and including the day of qualifying chest mri or ct scan date or currently receiving systemic therapy for acute or chronic graft-versus-host disease (gvhd) or presence of neutrophil dysfunction because of underlying acquired or primary immune deficiency (e.g. chronic granulomatous disease) on the date of the qualifying chest mri or ct scan * subject consent or parental/guardian permission (informed consent) and if appropriate, child assent exclusion criteria: * weight \<3 kg, so as to not exceed 3 ml/kg in a single blood draw * previous inclusion in this study
delta healthy sprouts: intervention to promote maternal weight control and reduce childhood obesity in the ms delta

Conditions: Obesity

Summary: the delta healthy sprouts project is a randomized, controlled trial evaluating the enhancement of an existing mother, infant, and early childhood home visiting program in 150 african american women in their early second trimester of pregnancy. the control arm, parents as teachers, is an evidence-based approach to increase parental knowledge of child development and improve parenting practices. the experimental arm, parents as teachers enhanced, builds on the parents as teachers curriculum by including nutrition and physical activity components specifically designed for the gestational and postnatal periods. both arms of the intervention will be implemented by community-based, trained parent educators. the comparative effectiveness of the two intervention arms on weight status, dietary intake, and health behaviors of mothers and their infants will be assessed. the delta healthy sprouts project will determine if a novel, scalable, lifestyle intervention can improve the health of african american women and their children at high-risk for obesity and chronic disease.


Eligibility criteria:
inclusion criteria: * at least 18 years of age * less than 18 weeks pregnant with first, second, or third child * resident of mississippi counties of washington and bolivar exclusion criteria: * pregnant with more than one fetus

Keywords: obesity pregnant women nutrition assessment health behavior