Kornimate/medical-research-clean huggingface dataset:
biofeedback treatment for functional constipation

Conditions: Constipation

Summary: the purpose of this randomized, controlled trial is to examine how well biofeedback treatment works to improve constipation. the study is comparing two kinds of biofeedback treatment: 1) anorectal-specific biofeedback therapy and 2) generalized biofeedback therapy using relaxation techniques. the study will also examine which medical and psychological factors determine biofeedback success for treating constipation, such as bowel habits, emotional reactions to constipation, and levels of stress and psychological distress.

this is a randomized controlled trial (rct) to evaluate the efficacy of anorectal biofeedback therapy for functional constipation secondary to pelvic floor dyssynergia. participants will be randomized to either six sessions of anorectal biofeedback or to six sessions of generalized biofeedback. participants will complete questionnaires at baseline, at completion of randomized treatment(12 weeks), and six months after completion of treatment to measure change in bowel habits, constipation severity, constipation-related quality of life, and constipation-related disability. an examination of psychosocial factors will also be conducted prior to treatment to distinguish which ones are predictive of biofeedback success for functional constipation.

Eligibility criteria:
inclusion criteria: * chronic constipation * medical recommendation to undergo biofeedback training

Keywords: biofeedback constipation
safety and effectiveness of the tornier simpliciti™ shoulder system in shoulder arthroplasty

Conditions: Shoulder Osteoarthritis

Summary: the aim of this observationnal post-marketing study is to provide additional information on the safety and effectiveness of simpliciti™ system at 24 months post-shoulder arthroplasty , in usual surgical practice.


Eligibility criteria:
inclusion criteria: * a subject must meet all of the following inclusion criteria in order to enter the study: * adult subject 18 years or older, * clinical indication for total shoulder or hemi replacement due to primary diagnosis of osteoarthritis, * scapula and proximal humerus must have reached skeletal maturity, * willing and able to comply with the protocol, * willing and able to personally sign the informed consent form, * subject is legally competent, understands the nature, significance and implications of the clinical investigation, and is able to form a rational intention in the light of these facts. exclusion criteria: * a subject will not be eligible to participate in the study if any of the following conditions is present: * lack of sufficient sound bone to seat and support the implant, including that resulting from skeletal immaturity, osteoporosis or erosive arthritis, * severe walch grade b2 glenoid defined as \>60% posterior head displacement and \>20% posterior glenoid bone loss, * metal allergies or sensitivity, * infection at or near the site of implantation, * distant or systemic infection.
exploring the effect of visual feedback on motion trajectory in a virtual reality environment.

Conditions: Stroke; Control

Summary: the rehabilitation intensity and frequency of upper extremities of stroke patients is insufficient. virtual reality technique may solved this problem. the investigators want to build up the motion trajectory system by head-mounted display virtual reality technique, and to explore the effect of visual feedback on motion trajectory in a virtual reality environment.

how to increase the rehabilitation intensity in the critical rehabilitation window for stroke patients (half year since onset) was very important. the training intensity and frequency of upper extremities is insufficient. the proprioceptive neuromuscular facilitation (pnf) movements of upper extremities are applied to all daily upper extremities movement. the goals of this study are that the investigators want to build up the motion trajectory system by head-mounted display virtual reality technique, and the investigators want to explore the effect of visual feedback on motion trajectory in a virtual reality environment. the investigators will record the motion patterns, motion trajectory and the deviation of position and angle comparing to the normal pnf movement pattern to analyze the motion accuracy.

Eligibility criteria:
stroke patients inclusion criteria 1. age:20\~100y/o. 2. stroke onset time \> 1 week, and neurological status and medical condition are stable. 3. brunnstrom stage iii to v. 4. can follow order. exclusion criteria 1. crucial organ failure, including heart, lung, liver, and kidney. 2. brain operation and epilepsy. 3. severe metal illness and aphasia, so cannot follow order 4. feel uncomfortable while using virtual reality. 5. crucial eye problems, including color-blind, weak color, cataract, glaucoma, etc. 6. mental illness, neuro-musculoskeletal system lesions, vertigo, claustrophobic. 7. illness and pain to affect upper extremities movement. healthy people inclusion criteria 1. age:20\~100y/o. 2. no pain to affect upper extremities movement. exclusion criteria 1. feel uncomfortable while using virtual reality. 2. crucial eye problems, including color-blind, weak color, cataract, glaucoma, etc. 3. cognition impairment, history of mental illness, neuro-musculoskeletal system lesions, vertigo, claustrophobic. 4. epilepsy.

Keywords: virtual reality
chronic disease health management information platform

Conditions: Hypertension

Summary: based on the combination of domestic and foreign experience and the needs of patients as the orientation, this research gives full play to the hospital's advantages in chronic disease management, and uses network information technology to develop a systematic and intelligent system that integrates prevention, diagnosis and treatment, follow-up, and education.

patients with hypertension are showing a trend of getting younger and younger, and high-normal blood pressure is increasing rapidly among the young and middle-aged people aged less than 65 years. young and middle-aged patients with hypertension have a lower absolute short-term cardiovascular risk, but their lifetime risk is higher. studies have shown that the awareness rate, treatment rate and control rate ("three rates") of young and middle-aged hypertensive patients in my country need to be improved urgently. improving the knowledge and behavior of young and middle-aged hypertensive patients with disease, treatment compliance and self-health management has become the focus of research. "internet + medical" through information network technology, innovative service models have become a trend.

Eligibility criteria:
inclusion criteria: * patients who are 18 to 59 years old according to the world health organization (who) age classification criteria, meet the diagnostic criteria for hypertension published in the "guidelines for the prevention and control of hypertension in china", and are diagnosed with essential hypertension; * patients are conscious and possess normal reading, comprehension and expression skills; * use a smart phone to surf the internet and send and receive information, accept and use the outpatient chronic disease health management platform services; * informed consent, voluntarily participate in this research. exclusion criteria: * patients with severe organic heart disease and other cardiovascular and cerebrovascular diseases; * chronic liver and kidney failure; * patients with malignant tumors; * persons who have participated in other forms of internet + health management.

Keywords: hypertension
rivaroxaban - percutaneous coronary intervention

Conditions: Coronary Artery Disease; Atrial Fibrillation

Summary: we investigated in-vitro the management of intraprocedural anticoagulation in patients requiring immediate percutaneous coronary intervention(pci) while using regular direct oral anticoagulants(doacs). twenty-five patients taking 20mg of rivaroxaban once daily comprised the study group, while five healthy volunteers included the control group. in study group, a beginning(24-hours after the last rivaroxaban dose) examination was performed. then, the effects of basal and four different anticoagulant doses(50iu/kg unfractionated heparin(ufh), 100iu/kg ufh, 0.5mg/kg enoxaparin, and 1mg/kg enoxaparin) on coagulation parameters were investigated at the 4th and 12th hours following rivaroxaban intake. anticoagulant activity was assessed mainly by anti-factor xa(anti-xa) levels.


Eligibility criteria:
inclusion criteria: * patients using the direct oral factor xa inhibitor rivaroxaban * atrial fibrillation exclusion criteria: * malignancy, * coagulopathy, * heart valve disease, * active infection, * chronic systemic or inflammatory disease, * recent acs or elective pci, * uncontrolled hypertension and diabetes, * cerebrovascular accident, * thyroid disorder, * left ventricular systolic dysfunction (ejection fraction \<50%), * glomerular filtration rate \<50 ml/min/1.73 m2, * underweight and overweight (\ 100 kg), * age \>75 years, * hyperbilirubinemia and hypertriglyceridemia (\>350 mg/dl).
subclinical hypothyroidism and acute anterior myocardial infarction: is it cardio-protective or not?

Conditions: Heart Injuries

Summary: the study plans to investigate whether recovery of the heart function after acute anterior myocardial infarction is dependent upon improvement in thyroid gland functioning.


Eligibility criteria:
inclusion criteria: * have suffered anterior myocardial infarction exclusion criteria: * do not receive thyroid treatment * no history of ischemic heart disease
fev1/fev6 and fev6 as an alternative for fev1/fvc and fvc in bolivian subjects

Conditions: Copd

Summary: comparison of fev1/fev6 and fev6 as an alternative for fev1/fvc and fcv in the detection of airway obstruction in a bolivian population

the data of consecutive adult smoker patients, referred to the clínica del pulmón (santa cruz, bolivia), between may 2018 and june 2018, will be analyzed. all the patients are current or ex-smokers, complaining of dyspnea, cough or expectorations. spirometry measurements will be performed with a medisoft body box 5500 by one highly trained and experienced pulmonologist according to the guidelines of the ats/ers. the criteria used to detect airway obstruction are either the fixed cut-off points according to gold recommendations (fev1/fvc\<0.70) or the lower limit of normal (fev1/fvc\<lln). these indices will be compared to a fixed cut-off fev1/fev6 \<0.73 as proposed by vandevoorde et al. or to a fev1/fv6 ration \< lln. reference equations used are those of caucasians from the nhanes iii survey. statistical tests will be done using ibm spss 24 software. cohen's κ will be used to determine if there is an agreement between the definitions of airway obstruction.

Eligibility criteria:
inclusion criteria: * adult smoker suspected of copd exclusion criteria: * unable to perform spirometry

Keywords: spirometry
a study comparing duloxetine to other antidepressants in the treatment of severe depression

Conditions: Depression

Summary: the purpose of this study is to compare duloxetine with other antidepressants in the treatment of severe depression.


Eligibility criteria:
inclusion criteria: * at least 18 years of age * have major depression and are currently in a severe depressive episode * have a degree of understanding such that patient can communicate with the investigator and study staff * all females must test negative for pregnancy * females of childbearing potential must use reliable method of birth control during the study and for 1 month after taking the last dose of study drug exclusion criteria: * have not responded to duloxetine for depression in the past * have a history of bipolar disorder, a psychotic disorder (such as schizophrenia), a cognitive disorder (such as moderate or severe dementia), or obsessive-compulsive disorder (ocd) * are at significant risk for suicide * have not responded to 2 or more adequate trials of antidepressant medications during the current depressive episode * have a serious, unstable medical condition * have a current or recent history of substance abuse or dependence * have had electroconvulsive therapy (ect), transcranial magnetic stimulation (rtms), or vagus nerve stimulation (vns) in the past year * have started psychotherapy within 6 weeks prior to study entry * have a serious medical illness or clinically significant laboratory abnormality that is not stabilized or is anticipated, in the judgment of the investigator, to require hospitalization or use of an excluded medication during the course of the study

Keywords: severe depressive episode
evaluation of the clinical and economic impact of painprimer in the treatment of low back pain in a primary care setting

Conditions: Low Back Pain

Summary: to evaluate the impact of painprimer in a prospective six-month clinical investigation looking at clinical outcomes, health care professional and patient satisfaction, healthcare resource use, productivity and direct and indirect costs. the hypothesis is that early identification of the presence of neuropathic pain and back pain related comorbidities, to direct appropriate pharmacologic and non-pharmacologic treatment, painprimer would improve patient outcomes and reduce patient cycling, inappropriate use of imaging and surgery, thereby reducing costs and productivity loss associated with these inefficiencies.


Eligibility criteria:
inclusion criteria: * those aged 18 years of age * presenting to a hcp with low back pain * able to speak, write, and understand both verbal and written english exclusion criteria: * conditions that may impede the patient's ability to participate in painprimer and complete the questionnaires, as per the hcp's discretion * patients presenting who have undergone surgery for back pain in the previous 12 months * patients with medicare as their primary insurance
rotational angiography in cryoballoon ablation

Conditions: Atrial Fibrillation

Summary: there is still unresolved question weather preprocedural imaging of left atrium and pulmonary veins is needed before the pulmonary vein isolation procedure for the treatment of atrial fibrillation. the investigators are conducting a randomized study to determine if 3d rotational angiography (as a mode of preprocedural imaging) performed before the cryoballoon ablation, facilitates the procedure and has positive impact on procedure characteristics and outcomes.

around 50% of cardiac electrophysiology (ep) centers are using some kind of imaging to define left atrium and pulmonary vein anatomy before the pulmonary vein isolation (pvi) procedure. most commonly, ct or mr are performed few days/weeks before the procedure. three dimensional rotational angiography is least commonly used. however it has the advantage that it can be performed in the ep room just before the ablation procedure. there is still no consensus if any kind of imaging is really needed to perform safe and effective pvi. the investigators want to determine if 3d rotational angiography (as a mode of preprocedural imaging) has positive impact on procedure safety and efficacy. also the investigators want to compare the immediate procedure characteristics. the investigators are conducting a randomized study with 1:1 randomization and planning to enroll around 100 participants with 1 year follow up.

Eligibility criteria:
inclusion criteria: * paroxysmal atrial fibrillation * persistent atrial fibrillation * scheduled for cryoballoon ablation exclusion criteria: * longstanding persistent atrial fibrillation * renal failure * contrast allergy

Keywords: preprocedural imaging atrial fibrillation rotational angiography
effect of consumption of black cumin (nigella sativa l.) water extract on weight loss in overweight women

Conditions: Obesity

Summary: the purpose of this clinical trial is to study the therapeutic effect of black cumin water extract (nigella sativa l.) on obesity and overweight

the worldwide prevalence of obesity has reached epidemic proportions mostly in low-income and transitional than in industrialized countries. changes in dietary habits and sedentary lifestyles are known to be associated with changes in health and increased prevalence of chronic diseases in the population. the need to promote healthy nutrition for the population must be pursued vigorously, as the escalation of nutrition-related chronic degenerative diseases - once an urban phenomenon - has now spread to the rural population at an alarming rate. during the past decades efficacious strategies have been developed for prevention of these diseases. these strategies involve general lifestyle changes, which include, healthy diet, optimal weight, physical activity, moderate or no alcohol consumption, control of diabetes mellitus and in particular, treatment of obesity. although the global market for satiety, fat burning and other weight management remedies has been grown, the awareness of the benefits of weight management ingredients is neither sufficient nor clearly perceived by consumer. subsequently, the opportunities for scientifically-substantiated weight management ingredients regarding the natural and herbal dietary pattern are impressive. the seed of nigella sativa (black cumin) is one of the most common traditional herbs for weight loss in the middle east which is usually used as a spice as well as traditional medicine to treat a variety of health conditions especially inflammatory diseases and obesity. furthermore, many of the components present in black cumin including polyphenols have been attributed to have anti-inflammatory and anti-obesity effect which further supports our hypothesis.

Eligibility criteria:
inclusion criteria: * being obese exclusion criteria: * having heart disease or renal disease * using drugs influencing metabolism and appetite

Keywords: obesity
5 alpha reductase inhibitors and the risk of suicide and depression

Conditions: BPH; Depression; Suicide

Summary: in december 2015, health canada issued a warning about a potential relationship between suicide and finasteride use and called for further research. no population based studies have assessed the risk of suicide with finasteride use, and this risk is not currently part of the product monograph. furthermore, the link between depression and finasteride has not been well studied in the older population who are the primary users of this medication.


Eligibility criteria:
inclusion criteria: * all men \>66 years of age in ontario between 2003-2013 exclusion criteria: * non ontario residents * no prescriptions filled in prior 180 days * prior exposure to finasteride/dutasteride in the 2 years prior to study enrollment. * prescription initiated during hospital admission or er visit.
meg and dti of neural function and connectivity in traumatic brain injury

Conditions: Traumatic Brain Injury; Post-concussive Symptoms

Summary: the overall hypothesis is that the long-term cognitive and behavioral sequelae of traumatic brain injury (tbi) are due to selective disruption of the long association white matter tracts of the cerebral hemispheres, with resulting functional impairment of the network of cortical regions that are interconnected by these long-range association pathways. we propose that traumatic white matter injury can be measured with diffusion tensor imaging (dti) and that the impaired cortical activation can be detected with magnetoencephalography (meg), and that the results of these imaging examinations will correlate with neurocognitive status and functional recovery after tbi.


Eligibility criteria:
inclusion criteria: * 18-50 years of age * single episode of blunt traumatic brain injury * symptoms of persistent post-concussive syndrome present an average of 4 months to 4 years since date of injury * fluency in english (cognitive battery not available in other languages) * capable of self-consent exclusion criteria: * \ 50 years of age * pregnancy * history of previous tbi with loss of consciousness * alcoholism as evidenced by audit questionnaire * regular use of illicit drugs * non-english fluency * significant psychiatric history excluding mild depression or anxiety disorder any contraindication to mri, including claustrophobia, pregnancy, any trauma or surgery which may have left ferromagnetic material in the body, ferromagnetic implants or pacemakers; and inability to lie still for 1 hour or more

Keywords: traumatic brain injury post-concussive symptoms brain imaging neurocognitive testing
testing the effectiveness of ww clinic glp1

Conditions: Weight Loss; Obesity

Summary: the study objective is to evaluate the efficacy of the weightwatchers (ww) glp-1 behavioral program + ww clinic (formerly known as sequence medical weight management program) on weight loss and related outcomes. participants will be invited to take part and answer surveys at 0, 12 and 24 weeks.

this is a 24 week prospective single-arm efficacy outcomes study. up to 180 adult participants who are currently enrolled in ww glp-1 behavioral program program + ww clinic (formerly known as sequence medical weight management program) and already prescribed semaglutide or tirzepatide. the application of a comprehensive lifestyle-based intervention focused on dietary intake, physical activity, support and behavioral principles in conjunction with anti-obesity medication (aom) is novel and may increase aom efficacy while minimizing maintenance concerns. as obesity care can now be delivered virtually, it will also include an innovative strategy of virtual/remotely delivered medical care via sequence and ww. further, this study will examine multiple psychosocial domains associated with weight loss and weight loss related outcomes including physical activity, dietary behavior, disordered eating, depression symptoms, internalized weight bias and community, that have not been examined in aom trials.

Eligibility criteria:
inclusion criteria: 1. 18 years or older 2. bmi of \>30 or bmi of \>27 with one or more weight related medically qualifying condition (hypertension, dyslipidemia, sleep apnea, cardiovascular disease) 3. access to a smartphone or tablet that runs ios/ipados 15.0 or later, or android 7.0 or later 4. a prescription for wegovy, mounjaro, or zepbound exclusion criteria: 1. diabetes 2. personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 3. history of pancreatitis within 180 days 4. previous surgical obesity treatment 5. use of other anti-obesity medication in last 90 days 6. use of glp-1 within the last 180 days 7. lost weight \>11 lbs in the last 90 days 8. pregnant, breastfeeding, intends to become pregnant, of child-bearing potential and not using a highly effective contraceptive method