Kornimate/medical-research-clean huggingface dataset:
helicobacter pylori eradication study in parkinson's disease

Conditions: Parkinson's Disease; Helicobacter Pylori Infection

Summary: it has been hypothesized, based on epidemiological observations, that helicobacter pylori (hp) infection may play a role in the pathogenesis of parkinson's disease (pd). previous studies have also shown that hp eradication therapy may result in improvements in levodopa pharmacokinetics and motor fluctuations. this study aims to examine the effects of hp eradication, using a double-blind randomized placebo-controlled trial design in a relatively large cohort of patients. outcomes of interest include motor function, gastrointestinal symptoms and health-related quality of life. the investigators hypothesize that hp eradication will lead to improvements in motor function. the primary outcome of interest is the "on"-medication unified pd rating scale (updrs) part iii score at 3 months. secondary outcomes include purdue pegboard score, timed test of gait, dyskinesia and bradykinesia scores measured by parkinson's kinetigraph (pkg), leeds dyspepsia questionnaire (ldq), parkinson's disease questionnaire (pdq-39), updrs part i, part ii and part iv; and montreal cognitive assessment (moca).


Eligibility criteria:
inclusion criteria: 1. aged ≥18 years 2. provision of written informed consent 3. clinical diagnosis of parkinson's disease (pd) assigned by a consultant neurologist exclusion criteria: 1. history of previous gastric or major abdominal/pelvic surgery 2. history of previous eradication therapy for helicobacter pylori 3. antibiotic use in the preceding four weeks or use of anti-acid/prokinetics/laxatives in the preceding one week prior to breath test 4. recent initiation of dopaminergic medications (within the last three months) or recent adjustment of dopaminergic medications (within the last one month) 5. history of functional neurosurgery for pd 6. no concomitant neurologic disease except pd 7. medical condition that prevents reliable completion of questionnaire

Keywords: parkinson's disease helicobacter pylori infection
ovarian stimulation: inositol and melatonin

Conditions: Infertility

Summary: an efficient protocol of ovarian stimulation is a key part of assisted reproductive technology. in order to obtain the highest oocyte retrieval with no adverse effects, numerous studies have evaluated the efficiency of the clinical approaches currently available. recent studies have shown that two natural compounds, such as inositol and melatonin, play an important role in oocyte maturation and quality. therefore, the present study aims at investigating whether inositol and melatonin are able to improve the number of oocytes obtained after ovarian stimulation with recombinant follicle stimulating hormone (rfsh). to this purpose, a randomized double-blind trial will be established where 150 healthy women in reproductive age undergoing to assistant reproductive technology (art) because of male infertility will be divided in two groups. group a will be treated with 225iu rfsh alone, group b will be treated with 225iu rfsh, 4g inositol and 3mg melatonin. as primary outcome of the study, oocyte quality, total number of oocytes retrieved, clinical pregnancy rate and live birth rate will be evaluated in group a vs. group b.


Eligibility criteria:
inclusion criteria: * female age 18-39 years * bmi 18-30 kg/m2, * fewer than 3 prior oocyte retrievals, * no fertility problems
development of a prediction platform for neoadjuvant treatment and prognosis in pancreatic cancer using organoid

Conditions: Pancreas Cancer

Summary: the investigators create organoid from the pancreatic cancer tissue obtained via eus-fna and eus-fnb within the pancreatic cancer diagnostic process. and also the investigators create organoid from the pancreatic cancer tissue obtained after surgery as part of the pancreatic cancer treatment process. check for the reactivity to anti-cancer drugs through cell viability assay after treating with various anti-cancer drugs, such as anti-cancer drugs used as neoadjuvant chemotherapy for pancreatic cancer to the organoid. also, perform genomic analysis on each organoid, and then check if there are any unique genomic mutations for each organoid. by recognizing the relationship between the unique genomic mutations and reactivity to the anti-cancer drug within pancreatic cancer patients eligible for surgery, the investigators aim to strategize appropriate neoadjuvant chemotherapy before surgery, thus developing a platform to predict the outcomes of each patient.


Eligibility criteria:
inclusion criteria: 1. 18 years old or older 2. newly discovered pancreatic cancer and not a relapse 3. diagnosed with pancreatic cancer via eus-fna, eus-fnb before surgery 4. who is in need of neoadjuvant chemotherapy before surgery 5. patients who can undergo surgery for pancreatic cancer after neoadjuvant chemotherapy 6. diagnosed with pancreatic cancer from the final tissue pathology diagnosis after surgery 7. able to make decisions for oneself for participation 8. has obtained voluntary consent in written form (if 70 years of age or older, receive consent from the guardian as well) exclusion criteria: • none
infections and autoimmunity: autobodies screening in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: the purpose of this investigation is to assess the prevalence of infectious disease seropositivity (toxoplasmosis, rubella, cytomegalovirus \[cmv\]), herpes simplex virus type 1 (hsv-1) and herpes simplex virus type 2 (hsv-2), syphilis, epstein-barr virus and h. pylori in a group of patients presenting with specific autoimmune diseases (rheumatoid arthritis \[ra\], undifferentiated connective tissue disorder \[uctd\], sjogren, antiphospholipid syndrome - aps, vasculitides, systemic lupus erythematosus \[sle\], polymyositis, hashimoto, multiple sclerosis, primary biliary cirrhosis \[pbc\], etc.), using the bioplex 2200 and complementary eia kits as compared to matched controls (by age, sex and ethnicity).

the purpose of this investigation is to assess the prevalence of infectious disease seropositivity (toxoplasmosis, rubella, cytomegalovirus \[cmv\]), herpes simplex virus type 1 (hsv-1) and herpes simplex virus type 2 (hsv-2), syphilis, epstein-barr virus and h. pylori in a group of patients presenting with specific autoimmune diseases (ra, uctd, sjogren, antiphospholipid syndrome - aps, vasculitides, sle, polymyositis, hashimoto, multiple sclerosis, pbc, etc.), using the bioplex 2200 and complementary eia kits as compared to matched controls (by age, sex and ethnicity). we will assess in our center 100 patients with multiple sclerosis for the antibody profile of different infectious agents. comparative assessments will be performed with normal matched subjects.

Eligibility criteria:
inclusion criteria: * definite multiple sclerosis exclusion criteria: * intravenous immune globulin (ivig) treatment

Keywords: multiple sclerosis antibodies serum infectious agents immunoglobulin g immunoglobulin m
brilliant blue versus indocyanine green

Conditions: Macular Pucker; Macular Hole; Vitreoretinal Surgery

Summary: a study of non-inferiority design comparing brilliant blue and indocyanine green as intraoperative dye in macular pucker and macular hole.


Eligibility criteria:
inclusion criteria: * age over 50 * macular pucker or macular hole with subjective disturbances * all phakic or pseudophakic patients * far visual acuity better than 20/400 * able to read, understand, and willing to sign the informed consent form exclusion criteria: * any other ocular disease or conditions compromising the visual acuity other than macular hole or macular pucker * prior vitreoretinal surgery in the study eye

Keywords: dye internal limiting membrane macular hole macular pucker
reproductive capacity and iron burden in thalassemia

Conditions: THALASSEMIA MAJOR

Summary: the improved long-term survival of thalassemia major (tm) patients has resulted in increased focus on the ability to preserve fertility. while the association of iron toxicity with vital organ dysfunction, heart and liver, has been extensively investigated, the correlation of reproductive capacity and extent of iron overload is not well understood. despite remarkable progress in methodology for prediction of reproductive status and intervention for preserving fertility, implementation in thalassemia is lacking. the investigators hypothesize that iron toxicity to the anterior pituitary occurring in the process of transfusional iron loading is directly associated with a decline in gonadal function. the investigators expect pituitary mri measurements of iron deposition as well as markers of oxidative damage to correlate with the functional studies of pituitary-gonadal axis performed in this study. this cross sectional study will examine the relation of pituitary iron deposition and pituitary volume; serum iron and oxidative stress measures, liver iron concentration (lic), cardiac iron and chelation adequacy with pituitary and gonadal reproductive hormone levels (and spermatogenesis in adult male patients), in order to better define the association of iron burden and chelation patterns with fertility potential, in thalassemia patients with iron overload. the study will assess whether the current chelation treatment regimens, in particular during the pubertal developmental age, are adequate for preserving fertility and could lead to improved chelation routines for preventing the high prevalence of compromised fertility. in addition, by utilizing state-of-the-art markers for fertility status, findings from this study may improve current methods for screening for hypogonadism and reproductive potential and allow earlier intervention. the investigators propose to examine 26-30 patients, 12 years and older, with measures of fertility potential, and correlate them to their current iron burden parameters and to the cumulative iron effect as indicated by past iron overload patterns and chelation history.


Eligibility criteria:
inclusion criteria: * transfusion-dependent\* females and males with thalassemia (any genotype) who are 12 to 45 years of age. * history of at least 5 years of chronic transfusion (defined as ≥ 8 transfusions/year) (age of initiation of transfusions does not matter) * any pubertal stage. * liver iron evaluated by squid, mri or liver biopsy within 12 months prior to enrollment in the study. * need to be able to stop hormonal therapy for 3 weeks (males) and one month (females) prior to study enrollment. exclusion criteria: * pregnant or lactating during study enrollment * unable to obtain liver iron concentration within 12 months prior or 6 months after study entry.

Keywords: infertility thalassemia iron overload pituitary iron load oxidative stress reproductive capacity and association to iron burden and chelation patterns in thalassemia major patients
physical capacity of patients with chronic obstructive pulmonary disease with and without supplementation of whey

Conditions: Pulmonary Disease, Chronic Obstructive; Dietary Supplements; Rehabilitation

Summary: chronic obstructive pulmonary disease is characterized by obstruction to pulmonary airflow and dyspnea. these characteristics are a consequence of exposure to harmful gases and particles that lead to oxidative stress in the lungs together with an exaggerated inflammatory response. in addition to respiratory impairment, chronic obstructive pulmonary disease has systemic manifestations, nutritional alterations, and exercise limitation. pulmonary rehabilitation is one of the most effective interventions in the treatment of chronic obstructive pulmonary disease, with one goal being to improve patient capacity. whey protein supplementation, concomitant with physical activity for patients with chronic obstructive pulmonary disease, aims to stimulate protein synthesis and decrease muscle catabolism that may be caused by exercise. the investigators aimed to evaluate the effects of whey protein supplementation supplementation on the physical capacity, body composition and tissue functionality of patients with chronic obstructive pulmonary disease in a pulmonary rehabilitation program.

a randomized clinical study will be carried out with 62 patients (31 patients per group) with chronic obstructive pulmonary disease who came from specialized departments of the pulmonology service of the hospital de clínicas of porto alegre and were referred to the pulmonary rehabilitation program of this institution. patients will be evaluated in relation to anthropometry, body composition, blood biochemistry, phase angle, dietary intake, physical capacity, muscle strength and lung function. the data will be processed in the statistical program spss version 17.0 and for statistical analysis they will be tested for their normality by the kolmogorov-smirnoff test and after this definition will be applied specific tests for parametric or non-parametric data, being they presented in the form of mean and standard deviation or median, minimum and maximum, according to their distribution. the differences will be considered significant for values of p \<0.05.

Eligibility criteria:
inclusion criteria: * have been referred for pulmonary rehabilitation for chronic obstructive pulmonary disease diagnosis; * stable for the last 3 months and have no contraindications to exercise (no infection, acute myocardial infarction, malignant neoplasms, renal or hepatic disease, ascites / edema or neuromuscular disease); * be 40 years or older; * being literate; exclusion criteria: * being a vegetarian; * make use of continuous oxygen; * present cognitive or functional changes that limit the execution of any of the proposed tests. * body mass index \<21.0 kg / m² and ≥ 35.0 kg / m².

Keywords: whey protein
preoperative relaxation training and acupuncture to minimize perioperative symptoms in breast cancer patients

Conditions: Breast Neoplasms

Summary: breast cancer surgery is associated with presurgical psychological distress and clinically significant side effects including postsurgical pain, nausea and fatigue. a few studies have examined how to intervene to assist women undergoing breast cancer surgery. for example presurgical hypnosis has been proven to decrease side effects and even intraoperative anesthesia use. besides the more psychologically based interventions there are a few studies suggesting positive effects of acupuncture on pain, anxiety and nausea in surgery patients.this study aims to investigate whether a presurgical relaxation training, acupuncture treatment or a combination of both therapies is able to reduce presurgical psychological distress an postsurgical side effects in breast cancer patients in comparison to usual care.


Eligibility criteria:
inclusion criteria: * clinically proven breast cancer with an indication for breast conserving surgery with max. 50% volume reduction * physical and psychological ability to take part in relaxation training exclusion criteria: * serious psychiatric disorder * to time span to surgery shorter than 2 weeks or longer than 20 weeks
evaluation of physical and cognitive industrial workload

Conditions: Work-Related Condition; Physical Stress; Mental Fatigue

Summary: the main aim of the project is to evaluate a novel upper body exoskeleton during simulated industrial work. in this stage of the project, a study analysing the physical and mental load during occupational work will be carried out. high risk tasks will be identified in the field and simulated in lab-setting to analyse physical and mental load using physiological and biomechanical data.these will include, but will not be limited to, non-ergonomic postures, for example performing operations above the head or reaching in front of, to the side of, or behind the body; flexing the arms for extended periods of time; and bending or twisting the torso to lift an object from low or distant locations. important items to assess in this task are the frequency and duration of tasks and activities, lifting characteristics, perceived physical effort and work-induced fatigue.


Eligibility criteria:
inclusion criteria: * male * 18 - 65 yrs old exclusion criteria: * injury

Keywords: fatigue mental fatigue signs and symptoms behavioral symptoms industrial work physical effort mental effort questionnaires ergonomic evaluation
clinical trial to evaluate the safety and efficacy of "citus dry syrup" in children with perennial allergic rhinitis

Conditions: Perennial Allergic Rhinitis

Summary: therapeutic confirmatory clinical trial to evaluate the safety and efficacy of "citus dry syrup" in children with perennial allergic rhinitis: double blinded, randomized, placebo controlled, parallel designed, multi-centered, phase iii study.


Eligibility criteria:
inclusion criteria: 1. children aged over 24 months and under 15 years. 2. patients who was diagnosed with perennial allergic rhinitis by immunocap test. 3. nis mean total score of 1-week in baseline should be over 4.0. exclusion criteria: 1. patient who is accompanied by the seriously abnormal symptom in respiratory system, such as pneumonia, cystic fibrosis, viral influenza, tuberculosis, asthma(status praesens). 2. patient who has cancer, diabetes mellitus, hypertension, cns disease, and metabolic disease which need medication. 3. patient who has rhinitis not caused by allergy. 4. acute or chronic sinusitis. 5. patient who has medical history of allergy in seasonal pollen during the trial. 6. patient who has had eyes or nose surgery within 3 months prior to the trial. 7. patient who has had eye or upper airway infection within 1 week prior to the treatment period. 8. beginning immunotherapy or dose of change within 1 month prior to the trial. 9. patient who has clinical history of sensitivity to allergic rhinitis medication. 10. patient whose heart function is abnormal: including heart failure, abnormal ecg test value that is clinically significant. 11. patient who has experience to have participated in other clinical trial within 2 months prior to the trial. 12. patient who has taken contraindicated medications in this study within 1 week(baseline period) prior to the treatment period. 13. for girl who had her first period, result of pregnancy test was positive.
the evaluation of the lower limb function after femur fracture's operation treatment

Conditions: Surgical Treatment

Summary: the goal of this study is the evaluation of lower limb function and the quaility of life of the patients after femur fracture operation treatment. lltq (lower-limb tasks questionnaire), lefs (lower extremity funcional scale), llfi-10 (lower limb functional index - 10) and llfi (lower limb functional index) will be used for all the patients.

all four questionnaires (lltq, lefs llfi-10 and llfi) will be translated and adopted to the polish conditions. the detailed medical/ epidemiological history will be collected in each patient. the fracture will be assessed based on the x-ray examination and will be qualified according to ao classification. nrs (numerical rating scale) will be used to assess the pain intensity. sf36, qol, csq, cope and hads questionnaire will be used to evaluate patient's the quality of life (subjective assessment). first assessment will be done before operation and then after 3, 6, 12, 24 month postoperation treatment. with this main study, there is a plan to assess not only femur fractures patients, but the investigators would like to have addtional groups of the patients with hip and knee allopasty and knee arthroscopy with slightly different follow-up period: before the oparation, 1 and 12 month after the treatment.

Eligibility criteria:
inclusion criteria: * signed patient informed consent * patients planned for the surgical treatment exclusion criteria: n.a.
persistence disease after laparoscopic shaving of rectal endometriosis

Conditions: Endometriosis, Rectum

Summary: when performing shaving of a rectal endometriotic nodule, the surgeon can use the macroscopic appearance of the nodule and the tactile feedback provided by the laparoscopic instruments to decide the area of the bowel that needs to be excised. theoretically, compared with segmental bowel resection, the shaving technique may expose the patients to a higher risk of persistence of intestinal endometriosis. the objective of this ultrasonographic study was to assess the risk of rectal endometriosis persistence following laparoscopic shaving of rectovaginal nodules.


Eligibility criteria:
inclusion criteria: * patients underwent laparoscopic shaving of rectovaginal endometriosis infiltrating the rectum exclusion criteria: * patients underwent previous bowel surgery (except appendectomy); * patients experienced postoperative complications (such as pelvic abscess, rectovaginal fistula, ureteral injuries)
telerehabilitation in mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: the main aim of the study is to evaluate the efficacy of the virtual reality rehabilitation system (vrrs) compared to usual care treatment for patients with mild cognitive impairment (mci). moreover, we will assess the possibility to prolong the beneficial effects of the treatment with an innovative telerehabilitation system. in the second phase of the present study we aim to evaluate the short and long term effects induced by the treatment of active (anodal) transcranial direct current stimulation (tdcs) applied to the left dorsolateral prefrontal cortex combined with vrrs compared to placebo tdcs stimulation combined with vrrs. the effects of the intervention on outcome variables will be assessed using a randomized controlled trial design with five groups. the investigators will assess the effects of vrrs system and of the implementation of the at-home treatment on the quality of life, cognitive and functional abilities.


Eligibility criteria:
inclusion criteria: * diagnosis of mci, defined according to standard criteria (petersen et al., 2011) * mini mental state examination (mmse) ≥24 * education ≥ 5 years * all of the subjects will have normal or corrected-to-normal vision and will be native italian speakers. * all participants reported subjective memory complaints and objective memory impairment, but no impairment of function in daily life. exclusion criteria: * visual perception disorder and/or hearing loss * history of major psychiatric disorders * any contraindication for tdcs such as a history of seizures, major head trauma, past brain surgery, a brain metal implant or a pacemaker.
collagen cross-linking with ultraviolet-a in asymmetric corneas

Conditions: Keratoconus; Corneal Diseases; Eye Diseases; Photosensitizing Agents

Summary: this study will assess changes in visual acuity and corneal symmetry after corneal collagen cross-linking (cxl) of asymmetric corneas.

this study will evaluate the results of corneal collagen crosslinking (cxl) in patients with conditions that include keratoconus, forme fruste keratoconus, post-lasik ectasia, pellucid marginal degeneration, forme fruste pellucid marginal degeneration, diurnal fluctuation post-radial keratotomy, or terrien's marginal degeneration. this is an outcomes study, all patients receive treatment.

Eligibility criteria:
inclusion criteria: * a diagnosis of at least one of the following conditions: 1. keratoconus 2. forme fruste keratoconus 3. post-lasik ectasia 4. pellucid marginal degeneration 5. forme fruste pellucid marginal degeneration 6. diurnal fluctuation post-radial keratotomy 7. terrien's marginal degeneration exclusion criteria: 1. corneal thickness \< 375 microns measured by ultrasound or pentacam. 2. contraindications or hypersensitivities to any study medications or their components. 3. pregnancy or breastfeeding. 4. any history of herpes simplex corneal disease in an eye to be treated. 5. nystagmus or any other condition that would, in the judgement of the investigator, prevent a steady gaze during the treatment. 6. inability to cooperate with diagnostic tests. 7. enrollment in another ophthalmic clinical trial.

Keywords: keratoconus forme fruste keratoconus post-lasik ectasia pellucid marginal degeneration forme fruste pellucid marginal degeneration diurnal fluctuation post-radial keratotomy terrien's marginal degeneration