Kornimate/medical-research-clean huggingface dataset:
investigation of iron uptake from micronutrient fortified powder versus from tailored control in milk

Conditions: Growth and Development

Summary: the present study supplements iron as part of multiple micro-nutrient supplementation to demonstrate that intake of a micronutrient fortified powder in milk helps increase the uptake of key micronutrients like iron due to unique nature of the given matrix, as compared to intake of iron alone in milk.


Eligibility criteria:
inclusion criteria: * demonstrates understanding of the study and willingness to participate as evidenced by participants' parents and/or legal guardian's voluntary written informed consent as well as written assent by the participant and has received a signed and dated copy of the informed consent form as well as the assent form * participant belonging to middle socio-economic background as per modified kuppuswamy scale * good general and mental health with, in the opinion of the investigator or medically qualified designee * child residing in the peri-urban areas of bangalore city * child with z-scores of: a. height for age of 0 to ≥-3; b. bmi for age of 0 to ≥-3. exclusion criteria: * children in care (cic) * known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds), any of their stated ingredients or any known food allergies like peanut allergy, gluten allergy or lactose intolerance * participants with severe anaemia (haemoglobin \< 8g %) as determined by laboratory results * current or relevant history of any serious, severe or unstable physical or psychiatric illness or any medical disorder that would make the participant unlikely to fully complete the study or any condition that presents undue risk from the study product or procedures in the opinion of the investigator * recent history (3 months) of serious infections, injuries and/ or surgeries * children consuming iron, calcium and/or other nutritional supplements and/ or health food drinks on a regular basis (more than 3 times a week) in last 6 months prior to screening visit * use of any prescription medications within 15 days prior to screening and throughout the entire duration of the study * recent history (within the last 1 year) of alcohol or other substance abuse.
effect of rofecoxib and a narcotic analgesic to treat pain following arthroscopic surgery (0966-179)(completed)

Conditions: Pain, Postoperative Arthroscopy

Summary: study the effect of rofecoxib 50 mg compared to both placebo, and hydrocodone 7.5 mg with acetaminophen 750 mg, to treat moderate to severe pain following arthroscopic knee surgery.


Eligibility criteria:
inclusion criteria: * elective outpatient arthroscopic knee surgery expected to last \<= 90 minutes using general anesthesia * patients must experience moderate to severe pain following surgery * patient must be in general good health as judged by the primary investigator exclusion criteria: * osteoarthritis; rheumatoid arthritis * allergy/sensitivity to aspirin, ibuprofen, indomethacin, other nsaids, cox-2 inhibitors (e.g., rofecoxib, celecoxib), hydrocodone, acetaminophen * asthma associated with nasal polyps * any arthroscopic knee surgery in the past 6 months
high flow nasal cannula and exercise in chronic obstructive pulmonary disease (copd)

Conditions: COPD

Summary: the aim of this study is to compare exercise capacity in copd patients through two different systems of supplemental oxygen delivery: high flow nasal cannula oxygen (hfnco) and the venturi mask (vm).

design: interventional, crossover, randomized. the main goal of this study is to compare the maximum speed reached in an incremental load treadmill test (iltt) and max time tolerated in a constant treadmill load test (ctlt) while using two different oxygen delivery devices (high flow nasal cannula oxygen and the mask venturi). patients will be evaluated through two different kinds of tests: incremental load treadmill test (iltt) and constant treadmill load test (ctlt). each test will be conducted two times, once using hfnco and the other time with the vm. in total, each patient will be evaluated four times on four different visits. the testing order will be randomized through stata. the following variables will be measured before, during and after each test: 1. max speed reached in an incremental load test: km/h 2. max time tolerate in a constant load test: in seconds 3. oxygen saturation: % 4. dyspnea: modified borg scale (0-10) 5. cardiac rate: beats per minute 6. respiratory rate: breaths per minute 7. blood pressure: mmhg 8. lower limbs fatigue: modified borg scale (0-10) 9. global comfort according to the device used: visual analogue scale (vas) 0-10

Eligibility criteria:
inclusion criteria: * long term oxygen therapy (ltot) or oxygen needs during exercise. * clinically stable defined as four weeks without exacerbation. exclusion criteria: * refusal to participate * any neuromuscular or cardiovascular or condition that limits test performance. * contraindication for exercise

Keywords: high flow nasal cannula copd pulmonary rehabilitation hfnc oxygen
radiation dose from computed tomography before and after implementation of a high pitch dual spiral technique

Conditions: Atherosclerosis of Coronary Artery; Cardiovascular Disease; Pulmonary Embolism; Aortic Aneurysm Without Mention of Rupture Nos

Summary: the purpose of this study is to compare the radiation exposure of a variety of chest ct examinations performed on the current state of the art ct scanners (64 slice, dual source ct scanner) with the radiation exposure for identical chest ct examinations performed on the siemens flash ct scanner (high pitch dual source spiral technique).

computed tomography has emerged as the "gold standard" for the diagnosis of a broad range of medical diagnoses. for cardiac imaging alone, the installation of ct scanners in us cardiology practices alone has tripled over the past 2 years. patients who undergo cardiac cta (computed tomography angiography) may be subjected to relatively high doses of ionizing radiation (ie. 4 times annual background radiation) during the diagnosis and management of coronary artery disease. current radiation doses for cardiac ct examinations are comparable to the effective doses for patients undergoing nuclear stress tests or cardiac catheterization (ie. approximately 10-15 millisieverts). in addition, non cardiac ct protocols, such as chest ct examinations for the evaluation of pulmonary arteries, thoracic and abdominal aorta, and lung nodules, are associated with significant radiation exposure. many patients undergo repeated ct examinations over several years for such pathology. there is a growing public concern regarding the cancer risk associated with such radiation. recent major technological advances have been made with the advent of newer generation ct scanners which allow significant radiation dose reduction. one such scanner, the dual source ct, is a new high pitch dual source spiral technique that offers the ability to image a patient's chest with ecg gated imaging protocols within a single second. these technological advances allow significant radiation dose savings, often resulting in effective radiation doses of less than one millisievert (msv).

Eligibility criteria:
inclusion criteria: * all patients who undergo chest ct examinations (including cardiac cta, and non cardiac ct examinations including pulmonary embolism, lung nodule and aortic pathology protocols)

Keywords: cardiovascular disease heart ct scan ct scan pulmonary embolisms aortography
effectiveness, tolerability and safety of rasagiline in early parkinson's disease patients not treated with levodopa

Conditions: Parkinson's Disease

Summary: study to look at the effectiveness, tolerability and safety of two doses of study medication in early parkinson's disease (pd) patients who have not been treated with levodopa.


Eligibility criteria:
inclusion criteria: men and women with parkinson's disease (pd) whose diagnosis is confirmed by at least two of the cardinal signs (resting tremor, bradykinesia, rigidity) being present, without other known or suspected cause of parkinsonism. subjects must be age 35 years or older. subjects not taking or requiring anti-parkinsonian medications, except for anticholinergics. exclusion criteria: subjects with unstable systemic medical problems or clinically significant malignancy, with particular attention to clinically significant or unstable vascular disease
dynamic data-driven management of atrial fibrillation using implantable cardiac monitors: the monitor-af study

Conditions: Atrial Fibrillation

Summary: observational, multi-center, retrospective study to evaluate the use of icm (implantable cardiac monitor) versus traditional, non-icm (non-implantable cardiac monitor) methods such as ecgs (electrocardiogram), holter, and mobile cardiac outpatient telemetry (mcot) units.

even with its increasing popularity and use, the impact of icms on af (atrial fibrillation) management is still being determined and can even be conflicting. furthermore, the use of icm is dependent on physician preference. it is hypothesized that dynamic monitoring with icms is superior to conventional methods and should be used for all patients with af. thus, it aimed to measure the outcomes of using icm versus more traditional approaches in patients with af.

Eligibility criteria:
inclusion criteria * patients \> 18 years of age * present for management of af * icm is inserted at the discretion of the treating physician exclusion criteria * patients \< 18 years of age * presence of a permanent pacemaker, implantable cardiac defibrillator, or cardiac resynchronization therapy * unable to tolerate icm or traditional monitoring with ecg, holter, or mcot monitoring * unable to tolerate aad, oac, and ca as part of af standard of care * icm inserted for cryptogenic stroke or syncope * was not followed \> 12 months * ca performed for af before icm implant
68ga-grazytracer pet assists in diagnosing pseudoprogression following immunotherapy in lung cancer.

Conditions: PET / CT; Lung Carcinoma; Immunotherapy

Summary: currently, there are limited methods available in clinical practice to distinguish pseudoprogression after immunotherapy. most patients rely on follow-up observations to monitor the disease, which does not meet clinical needs. 68ga-grazytracer is a novel imaging agent targeting granzyme b. by detecting the concentration of granzyme b, it reflects the localization of cytotoxic t cells in the tumor region and their potential ability to kill tumor cells. this study aims to leverage the simplicity, non-invasiveness, visualization, and semi-quantitative advantages of 68ga-grazytracer pet imaging to evaluate its effectiveness and feasibility in diagnosing pseudoprogression.


Eligibility criteria:
inclusion criteria: 1. lung cancer patients who develope lesion enlargement and/or new lesions after treatment with immune checkpoint inhibitors; 2. pseudoprogression cannot be ruled out in clinical practice; 3. lung cancer confirmed by pathology or cytology, regardless of pathological type; 4. fully-informed written consent obtained from patients; 5. patient ability to comply with protocol requirements; 6. age 18-75 years; 7. life expectancy of at least 6 months. exclusion criteria: 1. patients with serious diseases that the investigator deems unsuitable for participation in the clinical study. such as severe cardiopulmonary insufficiency, severe bone marrow suppression, severe hepatic or renal insufficiency, etc; 2. intestinal perforation, complete intestinal obstruction; 3. active phase of hepatitis b； 4. pregnant women and women who are potentially pregnant, as well as nursing mothers; 5. patients with poor compliance.
safety and efficacy of the btl-703 treatment for the non-invasive lipolysis

Conditions: Overweight; Obesity

Summary: the study will evaluate safety and efficacy of the btl-703 device for the non-invasive lipolysis.


Eligibility criteria:
inclusion criteria: * age ≥ 22 years * voluntarily signed informed consent form exclusion criteria: * implanted electronic device such as a cardiac pacemaker, bladder stimulator, spinal cord stimulator or electrodes for a myoelectric prosthesis, etc. * diabetics dependent on insulin or oral hypoglycemic medications * known cardiovascular disease such as arrhythmias, congestive heart failure * cardiac surgeries such as cardiac bypass, heart transplant surgery, pacemakers. * prior surgical interventions for body sculpting of thighs or buttocks such as liposuction * medical, physical or other contraindications for body sculpting/ weight loss * current use of medication known to affect weight levels and/or cause bloating or swelling and for which abstinence during the course of study participation is not safe or medically prudent * any medical condition known to affect weight levels and/or to cause bloating or swelling * active infection, wound or other external trauma to the area to be treated * pregnant, breast feeding, or planning pregnant before the end of the study * serious mental health illness * active or recurrent cancer or current chemotherapy and/or radiation treatment * negative affection to heat
the effect of endurance training in patients with prostate cancer

Conditions: Prostate Cancer; Insulin Sensitivity; Body Composition, Beneficial

Summary: the aim of the present study is to investigate the effect of endurance on psa doubling time in prostate cancer patients with an elevation in psa following radical prostatectomy for localized cancer. furthermore, underlying mechanisms such as reduction in inflammatory markers and improvement in insulin sensitivity and body composition are investigated.


Eligibility criteria:
inclusion criteria: * prostate cancer patients with an increase in psa following radical prostatectomy exclusion criteria: * severe cardiovascular disease * severe arthritis * severe neuropathy * severe hypertension * therapy with antidiabetic agents * other treatment for prostate cancer than radical prostatectomy
optimal treatment protocol for selective laser trabeculoplasty - repeat trial

Conditions: Glaucoma, Open-Angle; Pseudoexfoliation Glaucoma; Ocular Hypertension

Summary: glaucoma is a common eye disease that can lead to blindness. the only known way to reduce the rate of disease progression is by reducing the pressure in the eye (the intraocular pressure, iop). selective laser trabeculoplasty (slt) is an ophthalmic laser intervention with the purpose of reducing the iop. slt can be performed in different ways, with four of the treatment protocols being evaluated in the optimal slt (oslt) trial. slt is a repeatable procedure, but scientific evidence is scarce regarding more than one repetition. in this trial, patients included in the oslt trial will be invited to the extended trial (oslt-r), for further follow-up and re-treatment with slt, if needed.

subjects already included in the oslt trial (nct03798223) will be invited to the extended trial (oslt-r) at the time of slt re-treatment or when oslt follow up is scheduled to terminate. patients are re-treated as needed, according to the randomized group assignment performed in the oslt inclusion process. the oslt-r trial is aiming to elucidate: * if the slt efficacy, in terms of relative iop reduction (percent of baseline iop), changes with additional slt iterations. * if the longevity of iop reduction after slt changes with additional slt iterations. * if repeated slt is associated with a change in postoperative discomfort or adverse events. all of the above will be analyzed within each of the four treatment groups (slt protocols) in the trial. further, analysis will also be conducted regarding differences between the treatment groups regarding the above. further, analysis will be performed regarding slt efficacy depending of the total number of slt:s an eye has received, including those performed before entering the oslt and oslt-r trials.

Eligibility criteria:
inclusion criteria: * included in the oslt trial * followed up without the need for other treatment escalation than repeat slt exclusion criteria: * unable to participate in follow up due to health conditions, strength or physical location.

Keywords: selective laser trabeculoplasty
search for a link between the different variables for glycaemia and oxidative stress or impaired hdl function

Conditions: Type-1 Diabetes

Summary: as glycaemic variability on the one hand and hypoglycaemia on the other are associated with oxidative stress and inflammation, they are likely, in type-1 diabetic patients, to affect the oxidation of lipoproteins and hdl function, by altering their anti-atherogenic properties. the aim of this study is thus to determine, in patients with type 1 diabetic (t1d) who will wear a glycaemic holter for 1 week, the glycaemia parameters (mean glycaemia, duration of hypoglycaemia, duration of hyperglycaemia, mean amplitude of glycaemic excursions) associated with proatherogenic alterations in lipoproteins, in particular: * ldl oxidation * hdl oxidation and alterations of hdl function (anti-inflammatory capacity, antioxidant capacity)


Eligibility criteria:
inclusion criteria: * patients who have provided written consent * patients with national health insurance cover patients with t1d * t1d patients treated with insulin via a pump or multiple injections * hba1c \< 9.5 % control patients * normal fasting glycaemia (\< 6.1 mmol/l) * age \> 18 years, matched for sex and age with t1d patients all patients * normal serum hdl cholesterol (\> 1.04 mmol/l in men, \> 1.30 mmol:l in women) * serum ldl cholesterol \< 5 mmol/l * triglyceridemia \< 1.7 mmol/l * waist circumference \< 102 cm in men, \< 88 cm in women exclusion criteria: * smoking * kidney failure (creatinine clearance\< 60 ml/min/1.73 m2) * liver failure * dysthyroidism * medication that interferes with lipoprotein metabolism (lipid-lowering agents, oestroprogestative, anti-hiv, corticoids, retinoic acid), unless stopped for at least one 1 month * antioxidant (vitamin e, dietary supplements, dha) * pregnancy of more than 15d
acute effect of static stretching and pilates stretching on the muscle strength

Conditions: Muscle Strength; Muscle Strength Dynamometer

Summary: introduction: studies have shown that static stretching performed immediately before strength exercises impairs performance. however, unlike static stretching, dynamic stretching performed immediately before muscular strength exercises does not seem to result in worse performance, and in some cases may even provide greater strength performance. still, the literature is controversial and inconclusive to date. objective: to verify the acute effect of static stretching versus dynamic stretching on the muscle strength of young university students. methods: the sample will consist of 102 physically active young university students, of both sexes, aged between 18 and 25 years old, subdivided into three groups: group 1 - static stretching; group 2 - dynamic stretching; and group 3 - control. everyone will undergo assessment of the isokinetic peak torque of the knee extensor and flexor muscles at 60º/s and 180º/s in the dominant lower limb. next, the experimental groups (groups 1 and 2) will perform static or dynamic stretching exercises for the quadriceps and hamstring muscles, while the control group will not perform any activity. finally, everyone will undergo muscle strength assessment again according to the same procedures used initially. analysis of covariance (ancova) will be used to compare groups, with data from the initial assessment as adjustment covariates.


Eligibility criteria:
inclusion criteria: * to practice systematic physical exercises at least three times a week over the last six months; * healthy young adults, aged between 18 and 25 years; * agree to participate in the study by signing the free and informed consent form. exclusion criteria: * musculoskeletal injuries in the lower limbs; * pregnancy.
study on single-nucleotide-polymorphism in idiopathic membranous nephropathy

Conditions: Idiopathic Membranous Nephropathy

Summary: the purpose of this study is to analysis the different genotype in the idiopathic membranous nephropathy patients which with different therapeutic outcomes after treated by the comprehensive treatment regimen or immunosuppressive agents, and so as to looking for ideal markers to assess appropriate treatment approach and the long-term efficacy.

the primary objective of this study is to looking for the gene level predictors in the patients who suffered from idiopathic membranous nephropathy. and according to the predictors, the clinicians could make a decision which method should be taken on imn patients, traditional chinese medicine or western medicine, and could get better results.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of idiopathic membranous nephropathy * chronic kidney disease (ckd)≤3 stage（glomerular filtration rate (gfr)≥30ml/min）and 24 hour urinary protein≥3g * voluntarily participated in the study and signed an informed consent exclusion criteria: * combined life-threatening complications such as serious infection * abnormal glucose metabolism * patients with malignant tumors or malignancy , hiv infection and a history of mental illness , acute central nervous system disease , serious gastrointestinal diseases,etc * pregnancy or breast-feeding women * undergoing other clinical trials

Keywords: single-nucleotide-polymorphism traditional chinese medicine the comprehensive treatment regimen
covid-19 effectiveness study in the philippines

Conditions: COVID-19; Vaccine Effectiveness Against COVID-19; Hospitalized COVID-19

Summary: this is a multi-site, observational, prospective test negative design case-control study which primarily aims to determine the protective effectiveness of 2 doses of an inactivated covid-19 vaccine at least 14 days after the second dose, against hospitalized virologically-confirmed sars-cov-2 infection.


Eligibility criteria:
inclusion criteria: * written informed consent. * aged 18 years of age and above * residing in the catchment area of the participating hospital * admitted to the participating hospital with an acute respiratory illness * able and willing to provide a naso- and oro-pharyngeal swab for rt-pcr testing exclusion criteria: * 6.2.2.1 refusal to participate

Keywords: covid-19 vaccine effectiveness hospitalized covid-19 inactivated covid-19 vaccine