Kornimate/medical-research-clean huggingface dataset:
the orange-iii trial: optimised recovery with movicol® preoperatively within an enhanced recovery programme

Conditions: Liver Diseases

Summary: the aim of this study is to accelerate recovery after liver surgery by enhancing intestinal passage through the preoperative use of movicol. hypothesis the use of movicol® during one week prior to partial liver resection combined with the enhanced recovery after surgery (eras®) programme accelerates functional recovery by promoting early return of gastro-intestinal function, defined as the passage of stools and early oral intake.

rationale: the routine use of laxatives after liver surgery as part of an enhanced recovery after surgery (eras®) programme enhances recovery of gastro-intestinal function and early tolerance of oral nutrition. the use of macrogol (movicol®) as laxative during one week prior to partial liver resection will further enhance early return of gastro-intestinal function and accelerate functional recovery. objective: the aim of this study is to accelerate recovery after liver surgery by enhancing intestinal passage through the preoperative use of movicol® study design: the orange-iii trial is a multicentre randomised controlled trial to aim whether the administration of 1 sachet of movicol® during one week preoperatively and 2 sachets of movicol® postoperatively will further enhance early recovery compared to the administration of 2 sachets of movicol® postoperatively only, following liver surgery. all patients will be managed within an eras® programme of perioperative care. study population: patients requiring a partial liver resection (two or more segments), 18-80 yr old. main study parameters/endpoints: the main objective of the orange-iii trial is to provide evidence on early recovery of gastro-intestinal function defined as time to first intake of solid food continued for more than 24 hours after the use of movicol® during one week prior to partial liver resection within an enhanced recovery programme. secondary objectives are recovery of gastro-intestinal function defined as time to first stools and time to continuous intake of clear fluids for more than 24 hours, functional recovery, hospital length of stay and patient activity level.

Eligibility criteria:
inclusion criteria: * patients undergoing a partial liver resection * able to understand the nature of the study and what will be required of them * men and non-pregnant, non-lactating women between age 18-80 * bmi between 18-35 * patients with asa i-iii exclusion criteria: * inability to give written informed consent * patients requiring bile duct reconstruction * patients with asa iv-v * superextended hepatectomy * underlying symptomatic liver disease such as cirrhosis * underlying gastro-intestinal disease such as motility disorders * need for procedures additive to partial liver resection

Keywords: general surgery
diagnostic and prognostic biomarkers of idiopathic intracranial hypertension

Conditions: Benign Intracranial Hypertension

Summary: idiopathic intracranial hypertension (iih) is a condition of unknown etiology, primarily affecting overweight females of childbearing age. typically, patients experience headache and visual symptoms due to increased intracranial pressure (icp) and papilledema. the diagnosis is difficult, and outcomes vary from no sequelae to blindness or chronic headaches. no clear prognostic indicators exist. treatment consists of medication, weight loss, and possibly surgical intervention.there is an unmet need of defining biomarkers with prognostic or diagnostic value and defining predictors of a poor outcome. this project is a prospective, population-based cohort study including clinical data and a biobank (blood samples and cerebrospinal fluid). the investigator's primary aim is to identify biomarkers of diagnostic or prognostic value and to create a clinical iih database. the clinical database will answer questions about patient characteristics at baseline and during follow-up, identify predictors of outcome, and help create a standardized programme for follow-up and

this study is a multicenter, prospective, population-based cohort study with consecutive inclusion of patients in which the diagnosis of iih is suspected. this study is carried out in collaboration between the danish headache center, rigshospitalet-glostrup, and the neurological department at odense university hospital. patients are eligible for inclusion into the study if: 1. iih is suspected 2. \> 18 years old and able to provide written informed consent. at baseline included patients will have: a.) medical history b.) neurological, ophthalmological and general medical examination c.) relevant neuro-imaging d.) blood samples and lumbar puncture f.) evaluation by other specialist, including neuro-psychologists, if appropriate. subsequently patients are divided into three sub-groups according to revised friedmann criteria: 1. certain iih or iih-wop 2. suspected, but unconfirmed, iih 3. iih ruled out patients are followed at a headache center and by neuro-ophthalmologist according to standard clinical practice.

Eligibility criteria:
inclusion criteria: 1. able to and willing to provide informed consent 2. more than 18 years of age 3. suspicion of iih (based on clinical evaluation by neurologist or opthalmologist) exclusion criteria: 1.) unable to consent (e.g. language, mental retardation).
a study of brl49653c for the treatment of type 2 diabetes (combination therapy with sulfonyl urea) -with placebo study

Conditions: Diabetes Mellitus, Type 2

Summary: this study was designed to compare the efficacy and safety of brl49653c versus placebo with concomitant use of sulfonyl urea (su).


Eligibility criteria:
inclusion criteria: * patients with type 2 diabetes mellitus managed by su will be candidate for this study. these candidates will be checked up on their clinical laboratory data, and must have adequate blood, liver and kidney function. exclusion criteria: * patient with serious cardiovascular disease or serious hepatic disease will not be eligible.

Keywords: rosiglitazone avandia type 2 diabetes mellitus diabetes
training attentional awareness and control in adhd

Conditions: Attention Deficit Hyperactivity Disorder

Summary: the purpose of this study is to evaluate the effects of different types of cognitive training on attention in adults with attention deficit hyperactivity disorder (adhd) using mobile software on personal mobile devices.

different types of software-based cognitive training are thought to impact attention via different mechanisms. this study examines the nature of the effects on sustained attention of two different types of mobile software based training. because the nature of the training method is behavioral, the investigators can not divulge the differences in the training methods and their hypothesized differences in their impact on attention.

Eligibility criteria:
inclusion criteria: 1. meet established diagnostic and statistical manual-5 (dsm-5) criteria for adhd predominately inattentive or combined subtype with clinically significant levels of impairment, diagnosed by structured clinical interview, the mini international neuropsychiatric interview, and corroborating information 2. clinical global impression-severity (cgi-s) score ≥ 4 for adhd 3. no lifetime history of dsm-5 bipolar disorder, psychotic disorder, pervasive developmental disorder, obsessive-compulsive disorder, substance abuse, or substance dependence (except nicotine) as assessed with the mini-international neuropsychiatric interview (mini) 4. able in the opinion of the investigator to complete all required study procedures. exclusion criteria: 1. history of diagnosis of childhood disorder other than adhd (e.g. autism, dyslexia) 2. history of any general medical condition likely to require chronic use of medication with identified central nervous system (cns) effects suspected to alter cognitive performance 3. history of seizure disorder, brain tumor, other major neurological disorder or head injury resulting in loss of consciousness 4. serious oxygen deprivation 5. current psychopathology requiring ongoing treatment with antipsychotic medications, mood stabilizers, benzodiazepines, or anticonvulsants 6. current untreated psychopathology which is rated to be primary in terms of severity (greater than adhd severity) 7. current treatment with guanfacine.

Keywords: attention deficit hyperactivity disorder. attention training mobile devices brain training
the long term impact of bariatric surgery on quality of life

Conditions: Obesity

Summary: the primary purpose of this study is to examine the breadth, nature, and factors affecting the long term changes in physical and psychological health and quality of life (qol) following bariatric surgery. data will be gathered via electronic survey (surveymonkey), postal mail, or phone, or using a standardized questionnaire expected to last 25-35 minutes. archival data available from patient medical records will also be gathered.

information from existing databases and medical records will be used to obtain a list of phone numbers for persons who had roux-en-y bariatric surgery at the svbce five or more years ago at the st. vincent bariatric center of excellence (svbce. the interview includes scripts that the caller will use to recruit subjects in either direct conversation, in voice mail or by leaving a message. recruitment will cease after 400 complete post pilot interviews are obtained. the interview covers topics related to physical and psychological health and quality of life. the number of questions asked will vary from subject to subject since some questions are asked only if a prior question is answered affirmatively. for example, if a subject responds "yes" when asked "have you had plastic surgery?" the subject is then asked what type of procedure they had. the topics covered are as follows: weight, current health, post surgery complications, relationships, work, cross addiction, mental health, diet, television viewing, exercise, and life satisfaction.

Eligibility criteria:
inclusion criteria: * bariatric surgery patients of the st. vincent bariatric center of excellence who had surgery at least 5 years before the survey was administered. exclusion criteria: * patients having bariatric surgery at facilities other than st. vincent bariatric center. * patients who had bariatric surgery less than 5 years before the survey period.

Keywords: bariatric surgery long-term outcomes obesity
study of difluprednate in the treatment of uveitis

Conditions: Uveitis

Summary: the purpose of this study is to determine the safety and efficacy of difluprednate compared with prednisolone acetate in the treatment of endogenous anterior uveitis.


Eligibility criteria:
inclusion criteria: * diagnosis of endogenous anterior uveitis in at least 1 eye exclusion criteria: * presence of intermediate uveitis, posterior uveitis or panuveitis * corneal abrasion * any confirmed or suspected active viral, bacterial, or fungal keratoconjunctival disease * allergy to similar drugs, such as other corticosteroids
hpv-based screening among women 23-29 years of age

Conditions: Human Papilloma Virus; Cervical Intraepithelial Neoplasia; Cervical Cancer

Summary: the aim of the trial is to determine whether organized screening with primary hpv analysis provide higher cancer protection in the age group 23-29 years compared to primary cytology.

the aim is to investigate whether primary hpv analysis in the organized cell sampling program for women in the age group 23-29 provides higher cancer protection compared to the current method where cell samples are primarily analyzed with cytology. in this study, all women in the age group 23-29 in the stockholm and skåne region of sweden will participate. age is defined by year of birth. for 2020, women born 1991-1997 are included. sampling and collection of samples is the same as for cytology.

Eligibility criteria:
inclusion criteria: * women ages 23-29 invited to screening. exclusion criteria: * women who do not show up for screening or do not consent.

Keywords: organized screening hpv vaccination human papilloma virus prevention
diagnosis of pancreatic cancer by purine metabolite (hypoxanthine, xanthine) in urine

Conditions: Pancreas Cancer; Diagnosis

Summary: * this study aim to develope a diagnostic method of pancreatic cancer by using a reagent for analyzing purine metabolite (hypoxanthine, xanthine) in urine. * it is safe and cost effective compare to radiologic or blood test. it can be used for initial screening test for healty population.

* cubebio and seoul national university bundang hospital signed a joint technology development agreement to compare the analytical performance of existing analytical methods and purine metabolite analysis reagents developed by cubebio. * through quantitative analysis of hypoxanthine and xanthine in the urine of normal people and pancreatic cancer patients, we plan to confirm the possibility of diagnosing pancreatic cancer using reagents for analyzing purine metabolites. * early diagnosis of pancreatic cancer is a key determinant of cure and survival rates, and impact on all aspects of cancer, including rate of progression, treatment, and prognosis. * this study could change the paradigm of pancreatic cancer screening by evaluating the stability and accuracy of urinary purine metabolite analysis reagents.

Eligibility criteria:
1. pancreatic cancer group inclusion criteria: * pancreatic ductal adenocarcinoma that is pathologically confirmed or shows characteristic radiologic features * patients with resectable pancreatic cancer at the time of surgery (including borderline resectable pancreatic cancer at the time of diagnosis or locally advanced pancreatic cancer after chemotherapy or radiation therapy) * patients without invasion of adjacent organs other than the left adrenal gland and mesocolon * patients with informed consent exclusion criteria: * history of other malignancy (inclusive if there is no evidence of recurrence after 5 years of treatment) * patient with inflammatory disease(e.g. severe pancreatitis, cholangitis) * patients with underlying diseases at high risk of general anesthesia * other subject whom the investigator deems inappropriate 2. control group inclusion criteria included healthy individuals as well as patients with benign diseases. exclusion criteria for the control group included a previous cancer diagnosis within the past five years, active inflammatory diseases, borderline malignant pancreatic tumors, or a postoperative pathological finding of malignancy.

Keywords: pancreatic cancer hypoxanthine/xanthine concentration in urine
next generation sequencing detection of lyme disease

Conditions: Lyme Disease; Pediatric Infectious Disease; Erythema Migrans; Lyme Arthritis; Lyme Carditis; Lyme Disease Meningitis

Summary: next generation sequencing is capable of sequencing millions of small strands of dna from a single blood sample, potentially improving its sensitivity compared to pcr testing, which only detects predetermined larger strands of dna. we will test the ability of ngs to detect borrelia burgdorferi dna in the blood of pediatric patients with lyme disease. we will conduct an observational study of ngs testing on pediatric patients at all stages of lyme disease. study involvement will require a single study visit for clinical data collection and blood draw. we will enroll patients at all phases of suspected lyme disease, collect clinically relevant information, and test for lyme disease using next generation sequencing and standard lyme serologic testing. if the patient has multiple erythema migrans, lyme meningitis, facial nerve palsy, arthritis, or carditis, a b. burgdorferi serum pcr will also be sent. enrollment and next generation sequencing blood draw will occur before or up to 24 hours after the first dose of antibiotics is administered. we will also study the impact of antibiotics on ngs testing by running the test 6-24 hours after antibiotics are started among a small subset of patients with a multiple erythema migrans rash. collected data will be analyzed with basic descriptive statistics.


Eligibility criteria:
lyme disease subjects (cases): inclusion criteria: 1. age 1 to \<18 years old 2. the subject has spent time in a lyme-endemic area during the previous month 3. the subject has a suspected lyme disease infection exclusion criteria: 1. past infection with lyme disease 2. received oral or iv antibiotics within 1 month prior to presentation note: subjects may be enrolled if ngs blood test can be drawn \<24 hours after the first dose of lyme diseasetargeted antibiotics is administered

Keywords: next generation sequencing
tryptophan depletion in pd patients treated with stn dbs

Conditions: Parkinson's Disease

Summary: the purpose of this study is to assess the effect of tryptophan depletion on mood and behavior in parkinson's disease (pd) patients treated with deep brain stimulation (dbs) of the subthalamic nucleus (stn). by doing this, the investigators hope to be able to identify risk factors for and mechanisms underlying psychiatric side effects of stn dbs. the study will be an intervention study with a placebo controlled, randomized cross-over design.

parkinson's disease (pd) is a neurodegenerative disorder characterized by motor symptoms such as tremor, rigidity and slowness of movement. in later stages of the disease, when pharmacological treatment becomes less efficient, deep brain stimulation (dbs) of the subthalamic nucleus (stn) becomes a treatment option. although motor symptoms improve significantly by dbs, a number of operated patients experience severe side effects, mostly related to mood, cognition or behavior. these adverse effects are most likely mediated through the serotonin (5-ht) system. additionally, a dysfunction of the 5-ht system is implied in the pathophysiology of pd. pd patients are therefore regarded as 'vulnerable' to experiencing mood, cognitive and emotional problems due to changes in 5-ht activity. to elucidate whether stn dbs is indeed the trigger for psychiatric and cognitive problems to arise in the pd patient, the 5-ht levels in pd patients implanted with stn dbs will be manipulated. in order to do this, the investigators will make use of the tryptophan (trp) depletion method, an established research paradigm. in trp depletion, the brain is depleted of trp, the precursor of 5-ht, which consequently leads to lowered 5-ht levels. in both the normal and 5-ht depleted condition, mood- and cognitive parameters of the pd patients both with the stn stimulation on (on) and off (off) will be assessed. the goal is to get more insight into the effects of stn dbs in pd patients with a 5-ht vulnerabililty and the effects on 5-ht related mood and cognitive behaviour. this way, possible risk factors for and mechanisms underlying psychiatric side effects of stn dbs can be identified. the study is an intervention study with a placebo controlled, randomized cross-over design.

Eligibility criteria:
inclusion criteria: * subjects must be mentally competent * subjects must have undergone stn dbs surgery for pd symptomatology exclusion criteria: * head injury * stroke * currentl malignancy or infection * neurological disorders other than pd * psychoactive medication: specifically antidepressants and antipsychotics ( a stable dose of benzodiazepines will be allowed) * clinically relevant cognitive decline, operationalized as a mmse score \< 24 * current psychiatric syptomatology, operationalized as a hamilton depression scale score \> 16 or a score \>2 on one of the mds-updrs section i, items 1-6

Keywords: parkinson's disease deep brain stimulation subthalamic nucleus tryptophan depletion serotonin
continuous lumbar plexus block for postoperative pain control after total hip arthroplasty

Conditions: Postoperative Pain

Summary: continuous lumbar plexus and femoral blocks have been demonstrated to provide effective postoperative analgesia of the lower extremity following total joint arthroplasty. the purpose of this study was to compare these two techniques when used with intravenous patient-controlled analgesia and the use of patient-controlled analgesia alone for postoperative pain management following unilateral total hip arthroplasty.

above may be applied

Eligibility criteria:
inclusion criteria: * 18-80 years old * primary diagnosis of osteoarthritis exclusion criteria: * allergy to local anesthetics * peripheral neuropathy * opioid dependency * dementia * coagulopathy

Keywords: continuous lumbar plexus,femoral,hydromorphone
impact of implant supported overdenture on changes of electromyographic and brain activity

Conditions: Implant Supported Overdenture

Summary: the purpose of this study is to evaluate and compare the effects of a mandibular implant-supported overdenture with a mandibular complete denture on electromyographic activity, brain activity, and cognitive performance in edentulous patients. ten patients who are entirely edentulous and did not wear dentures will be chosen. to assess brain activity and cognitive function, electroencephalograms, the mini-mental state examination (mmse), and electromyographic examinations of the temporalis and masseter muscles will be performed prior to complete denture construction, one and three months after complete denture construction, and one and three months after implant supported overdenture insertion, respectively.


Eligibility criteria:
inclusion criteria: * all patients' ridges should be covered with firm mucosa which is free from any signs of inflammation or ulceration. * patients should be free from any bone disorder and exhibit adequate height and width of the residual alveolar ridge. * all patients must have sufficient inter arch space. exclusion criteria: * patients with oral or systemic diseases. * patients with xerostomia or excessive salivation. * patients with parafunctional habits (bruxism or clenching). * heavy smoker or alcoholic patients. * patients with history of temporo-mandibular dysfunction. * patients with neurological or psychiatric disorders.
improving bladder function in sci by neuromodulation

Conditions: Spinal Cord Injury

Summary: this trial will investigate the safety and utility of spinal cord neuromodulation to improve urinary bladder function in the context of spinal cord injury.

this trial will investigate the safety and utility of spinal cord neuromodulation to improve urinary bladder function in the context of spinal cord injury. neuromodulation will be in the form of transcutaneous electrical stimulation and/or magnetic stimulation.

Eligibility criteria:
inclusion criteria: 1. male 18-45 years; 2. at least 1 year post-injury; 3. non-progressive sci at c2-t8 (non-conus injury); 4. motor complete asia (a or b); 5. neurogenic bladder requiring clean intermittent straight catheterization; 6. able to attend twice weekly testing sessions for 6 months. 7. have intact lower extremity anatomy and able to use lower extremity for assistive standing and stepping. exclusion criteria: 1. history of autonomic dysreflexia; 2. ventilator dependency; 3. musculoskeletal dysfunction, unhealed fracture, pressure ulcer, active infection; 4. clinically significant depression or ongoing drug abuse; 5. received botox injection, or bladder surgery (suprapubic access, brindley procedure, etc.); 6. prostatic hypertrophy or bladder outlet disorder; 7. cardiopulmonary disease that precludes lower extremity training or rehabilitation.