Kornimate/medical-research-clean huggingface dataset:
nuga (nutrition for gastric cancer patients)

Conditions: Gastric Cancer

Summary: the objective of this pilot study is to evaluate the feasibility and efficacy of rhexium onco nutrition, hdt-202 for post-operative care in patients who have undergone gastrectomy.

1. a total of 4 visits will be performed. 2. at the screening visit,subject's written informed consent, assessing the inclusion/exclusion criteria and assigning enrollment numbers to eligible subjects, demographic information taking, medical history/medication history taking, vital signs measuring, physical examination, height and body weight measuring, instructing how to install/use the investigational device, and administering quality of life questionnaires. 3. during the treatment period, a total of 3 visits will be performed. to evaluate feasibility and efficacy, the following procedures will be carried out: vital signs measuring, physical examination, nutrition assessment/consultation, evaluation of feasibility for 'subjects', evaluation of feasibility for 'investigators', and adverse events (aes)/concomitant medications checking and collecting. 4. during the treatment period, telephone monitoring is conducted depending on the compliance of subjects.

Eligibility criteria:
inclusion criteria: 1. patient who voluntarily signs the informed consent form for this study 2. age of ≥19 years old 3. patient who has undergone therapeutic gastrectomy after a diagnosis of gastric cancer 4. able to eat food orally after gastrectomy 5. patient who possesses an android os based mobile device and is capable of using the investigational device. exclusion criteria: 1. other cancer or metastasis documented within 5 years prior to screening 2. ongoing or planned enteral tube feeding or total parenteral nutrition 3. other clinically significant medical or psychiatric findings based on which the individual is considered by the investigator to be ineligible 4. individual who possesses a mobile device on which the application is unable to be installed and/or run normally for technical reasons 5. individual who, in the opinion of the investigator, has difficulty understanding how to use the investigational device or is unlikely to comply with other study procedures

Keywords: gastrectomy postoperative care nutrition digital health technology application
randomized, double-blind (db), placebo-controlled 18 week study of linagliptin (bi 1356) in type 2 diabetic patients with insufficient glycaemic control on a sulfonylurea drug

Conditions: Diabetes Mellitus, Type 2

Summary: efficacy and safety of bi 1356 compared to placebo in patients with type 2 diabetes who have insufficient glycaemic control despite treatment with a sulfonylurea drug.


Eligibility criteria:
inclusion criteria: patients between 18 and 80 years old with type 2 diabetes and insufficient glycemic control \[glycosylated hemoglobin (hba1c 7% to 10%)\] despite therapy with a sulfonylurea drug exclusion criteria: myocardial infarction,stroke or transient ischaemic attack in last 6 months treatment with rosiglitazone, pioglitazone, glp-1 analogues, insulin or anti-obesity drugs in the past 3 months impaired hepatic function severe renal impairment current treatment with systemic steroids change in thyroid hormone dosage hereditary galactose intolerance
kisspeptin levels in early pregnancy

Conditions: Early Pregnancy; Ectopic Pregnancy

Summary: kisspeptins are a family of neuropeptides that are critical for the puberty initiation and female fertility. the investigators aimed to investigate in this study kisspeptin levels in early pregnancy, ectopic pregnancy, and early pregnancy loss.

clinicians can easily do a differential diagnosis of early pregnancy, miscarriage, and ectopic pregnancy when the human chorionic gonadotropin (hcg) values higher than 2000 miu/ml with transvaginal ultrasound. however, in cases where the hcg value is below the critical threshold of 1500 to 2000 miu/ml (often called the discrimination level) and ultrasound is not likely to be diagnostic, the pregnancy is of unknown location. plasma or serum kisspeptin is mainly derived from the placenta during pregnancy and plasma kisspeptin levels significantly increase across pregnancy. plasma kisspeptin levels could be used as a potential biomarker for the discrimination of miscarriage and ectopic pregnancy. all statistics will be carried out with the use of spss (ver. 21, ibm). a p value of \<.05 is considered to be statistically significant. pearson chi-square test will be used to evaluate between-group differences by pregnancy outcome for categoric data. kisspeptin differences will be calculated between groups with one way anova.

Eligibility criteria:
inclusion criteria: women aged between 18-37 years presented with between 5-6 weeks of gestation by last menstrual period. exclusion criteria: * women older than 37 years or younger than 18 years * women with a molar pregnancy, multiple gestations, gestational age past 6 weeks at the time of blood draw, or if pregnancies were assisted conceptions

Keywords: kisspeptin ectopic pregnancy
effect of different irrigation solutions on postoperative pain and lesion healing

Conditions: Endodontic Disease

Summary: in this study researchers plan to conduct, three different irrigation solutions that are responsible for the release of growth factors necessary for the success of regenerative endodontic treatments will be used. these solutions; ethylene diamine tetra acetic acid (edta), etidronic acid and citric acid. the aim of this study is to evaluate the effect of different irrigation solutions used in regenerative endodontic treatment of necrotic open apex molar teeth on postoperative pain. additionally, the healing of these teeth will be monitored for 1 year.

root canal treatment is a treatment method applied to milk and permanent teeth. the inflamed and necrotic pulp where the root canal is located is cleaned, debrided chemo-mechanically, and finally filled hermetically with a biocompatible material. necrotic immature teeth lose their restorative and defensive abilities. since the root canal walls of these teeth are thin and weak, regenerative endodontic procedures are applied more frequently in the treatment of immature teeth to ensure root development and to restore the vitality of the pulp tissue. in this study researchers plan to conduct, three different irrigation solutions that are responsible for the release of growth factors necessary for the success of regenerative endodontic treatments will be used. these solutions; ethylene diamine tetra acetic acid (edta), etidronic acid and citric acid. the aim of this study is to evaluate the effect of different irrigation solutions used in regenerative endodontic treatment of necrotic open apex molar teeth on postoperative pain. additionally, the healing of these teeth will be monitored for 1 year.

Eligibility criteria:
inclusion criteria:• molars with open apex * teeth with apical periodontitis * teeth for which prosthetic restoration is not planned * patients between the ages of 8-15 who do not have any significant health problems * patients who are not accompanied by periodontal problems and have good oral hygiene exclusion criteria:• people with systemic disease and allergic reactions * severely damaged teeth * if the tooth has previously undergone root canal treatment. * use of antibiotics, anti-inflammatory and painkillers in the last two weeks
natural history of pedal puncture wounds in diabetics

Conditions: Diabetes

Summary: there are no evidence (research) based guidelines for treatment of early, closed puncture wounds of the feet in diabetics. surgeons usually see only the limb- and life-threatening consequences of puncture wounds of the feet in diabetics, and are therefore tempted to advocate more aggressive, preemptive, invasive primary treatment for all such wounds, assuming, from this blinkered perspective that all such wounds progress to serious infection. this study is designed to determine the natural history of puncture wounds of the feet in diabetics, specifically, whether all become infected or whether some do heal without any surgical intervention. it requires administration of a questionnaire to 188 known diabetics attending 11 selected outpatient health care centers in the parish of st. james, jamaica.


Eligibility criteria:
inclusion criteria: * diabetic * 15 years and older * resident in the parish of st. james, jamaica exclusion criteria: * impairment of conscious level or mental status such that autonomy is compromised

Keywords: pedal puncture wounds infection in pedal puncture wounds diabetes education and pedal puncture wounds
sustainable healthcenter implementation prep pilot study

Conditions: HIV Chemoprophylaxis; HIV Preexposure Prophylaxis

Summary: a health services implementation pilot study, conducted with an observational cohort of hiv-uninfected persons including men who have sex with men, heterosexual women and men, and injection drug users receiving daily oral antiretroviral preexposure prophylaxis (prep) at four federally qualified health centers that provide sexual health and primary care services to communities with high hiv incidence/prevalence.


Eligibility criteria:
inclusion criteria: * adult * documented without hiv infection (acute or established) * report sexual behaviors that indicate substantial risk of hiv acquisition * report injection-related behaviors that indicate substantial risk of hiv acquisition exclusion criteria: * \<18 years of age * documented hiv infection (acute or established)

Keywords: preexposure prophylaxis prep hiv
effect of paired testing to poorly controlled chinese diabetes on glycemic control and self care

Conditions: Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 1

Summary: this study aims is to evaluate the effect of introducing paired testing on actual testing frequency, glycemic control, psychosocial and behavioural aspects of poorly controlled diabetes patients in china.

self monitoring of blood glucose (smbg) in insulin treated type 1 and type 2 diabetics has consistently been demonstrated to confer benefits, and is considered an essential part in the management of diabetes. in china, utilization of smbg among diabetes patients is low. even among those who perform smbg regularly, the daily testing frequency falls short of those recommended in international and national clinical guidelines. there is thus a need to create the awareness of the benefits of smbg and at the same time establish a smbg regimen that is deemed practically feasible and cost effective for diabetes patients. paired testing entails the act of measuring glucose level before and after an event that may impact the glucose level in a patient, e.g. meals, exercise, medication adjustment, and thereafter responding to any abnormal glucose levels/patterns by modifying lifestyle and/or medication. this study aims is to evaluate the effect of introducing paired testing on actual testing frequency, glycemic control, psychosocial and behavioral aspects of poorly controlled diabetes patients in china.

Eligibility criteria:
inclusion criteria: * diagnosed with diabetes mellitus * hba1c ≥ 8% measured within the a month prior to enrolment * have not been performing smbg on a regular (daily) basis within the 3 months prior to enrolment * willing and able to use accu-chek® active blood glucose meter to perform daily smbg * willing and able to complete participant questionnaires * willing and able to visit the physician at month 3 and month 6 * provide informed consent prior to enrolling in the study exclusion criteria: * any retinopathy that required photocoagulation or retinal surgery in the 6 months prior to enrolment or that may require photocoagulation or retinal surgery during the study * any clinically significant condition that required hospitalization in the last 2 months prior to enrolment or that may require hospitalization (e.g. elective surgery) during the study * any clinically significant psychosis or cognitive impairment * unlikelihood to comply or complete the study * women who are pregnant, lactating or planning to become pregnant during the study period

Keywords: type 1 diabetes type 2 diabetes paired testing
full mouth ultrasonic debridement carried out with either piezoelectric or magnetostrictive device

Conditions: Periodontitis, Adult

Summary: the treatment of periodontitis requires the removal of dental biofilm through both professional mechanical plaque removal and at-home oral hygiene practices. this study aims to compare clinical and psychological outcomes following professional treatment using either piezoelectric or magnetostrictive ultrasonic devices.

patients diagnosed with periodontitis will be screened for eligibility criteria. a comprehensive full-mouth periodontal assessment will be conducted by a calibrated examiner to determine the severity and extent of the disease. subsequently, patients will receive oral hygiene instructions, and group allocation will be revealed using a sealed envelope. based on the assigned group, full-mouth ultrasonic debridement will be performed by a trained operator. patient perceptions regarding the treatment will then be recorded. after three months, patients will return for a follow-up periodontal evaluation.

Eligibility criteria:
inclusion criteria: * \>18 years * periodontitis of stage 1 and 2 * absence of systemic chronic disease exclusion criteria: * anticoagulants treatment * antibiotic treatment 3 months before the screening visit

Keywords: periodontitis patient centred outcomes magnetostrictive
comparision of different methods of enviromennt disinfection

Conditions: Enviroment Cleaning

Summary: multidrug resistance bacteria infection is common in icu. infection incidence is associated with age, organ dysfunction, invasive treatment and enviroment cleaning. according to hospital hygienic standard for disinfection, total numbers of colony of air and the object surface in icu must be ≤4cfu/cm2（5min）and≤10cfu/cm2. in this study, the two different methods will be used to evaluate the disinfection effects in icu enviroments.


Eligibility criteria:
inclusion criteria: no patients recruitment exclusion criteria: no patients recruitment

Keywords: clean supplies icu floor bacteria colony catheter associated with infection
impact of level and quality of immunosuppression on onset and pattern of cardiac allograft vasculopathy evaluated by oct

Conditions: Transplant; Failure, Heart

Summary: the aim of this study is to use the high resolution of optical coherence tomography to assess the prevalence of different types of cardiac allograft vasculopathy (cav) in cardiac transplanted patients and correlate those results with the level of immunosuppression

cav is the most common reason for retransplantation at \>1 year and one of the main risk factors for mortality after cardiac transplantation. for this registry, patients planned to undergo coronary angiography either as a part of routine follow-up to screen for relevant cardiac allograft vasculopathy or because of clinical suspicion of relevant cardiac allograft vasculopathy will be considered eligible. since the "transplant care guidelines of 2010" recommend the use of intracoronary imaging during angiographic follow-up in patients after heart transplantation to recognize cav as early as possible, oct has become integral part of the cav diagnostic in our center. through its high resolution oct (so called virtual histology) provides the earliest possible diagnosis of cav as well as new insights into the differentiation of cav types. we aim to correlate the findings of oct with the level of immunosuppression.

Eligibility criteria:
inclusion criteria: * patients after cardiac transplantation undergoing planed routine angiographic examination and intracoronary imaging. * written informed consent exclusion criteria: * age \< 18 years old * hemodynamic and/or electric instability * chronic kidney failure with glomerular filtration rate \< 30 ml/min * pregnant or breastfeeding women * incapacity of providing informed consent * if in the investigator's opinion the patient has (a) co-morbid condition(s) that could limit the patient's ability to participate in the study or impact the scientific integrity of the study * any contraindication to intracoronary imaging

Keywords: oct cardiac allograft vasculopathy cav intravascular imaging
evaluating the impact of evidence-based information about psa testing on prostate cancer screening decisions

Conditions: Prostate Cancer

Summary: patient decision aids are tools that help guide individuals through a healthcare-related decision making process. they help users combine evidence-based information and recommendations by a health care provider with their personal needs, values and preferences. through this project, dr. dobbins and her research team will explore whether the use of patient decision aids with high-quality and user-friendly summaries of research evidence, or summaries of research evidence alone, help to improve the quality of decision making by men facing prostate cancer screening decisions.

guidelines for prostate screening in canada are based on low-moderate quality evidence of effectiveness and screening is associated with potential harms. patient decision aids (pdas) are tools that assist users to understand treatment options, risks and benefits to align decisions with values and preferences. the investigators would now like to know whether use of a pda alongside evidence-based information provided through the mcmaster optimal aging portal, or simply access to evidence-based information alone, can help users to make informed decisions about prostate cancer screening in men.

Eligibility criteria:
inclusion criteria: * english speaking men, \> 50 years old exclusion criteria: * history of prostate cancer or psa test in the last 12 months

Keywords: screening psa testing patient decision aid
the additional effect of hallux valgus correction on runners with first ray instability and patellofemoral pain syndrome

Conditions: Patellofemoral Pain Syndrome; Hallux Valgus

Summary: the study purpose is to investigate the effectiveness of a program combining biomechanical taping with lower extremity neuromuscular exercises for runners with patellofemoral pain syndrome (pfps) and hallux valgus

this will be a single-blind, experimental study with two treatment groups. a total of 30 college athletes with pfps and hallux valgus and majoring in long distance running or soccer, or recreational runners in taipei metropolitan area will be recruited. a set of clinical examination will be conducted to rule out abnormal knee structures, pathologies, or injuries apart from pfps. the lower extremity alignment as well as hip and knee kinematics during a step down test will be tracked using noraxon's myomotion system. muscle activation of the muscles controlling the hip and knee movements during the step down test will be recorded using telemyo dts of noraxon. hallux valgus angle will be measured with surface markers on photographs. knee pain level will be rated in a visual analog scale. the investigators will analyze the data with statistical product and service solutions (spss) for windows. repeated-measure anovas will be used to examine group-by-time interaction on all the outcome variables. all significance level will be set at 0.05.

Eligibility criteria:
inclusion criteria: * high physical activity level (running at least 5 times/week and at least 2 hours/time) * presenting anterior/retropatellar knee pain in the past 6 months * at least two of the following activities provocated symptom: prolonged sitting, ascending and/or descending stairs, squatting, kneeling, running, limping * not having any pathologies of knee joint (ligament tear, menisci injury, patellofemoral joint dislocation, tendinitis, bursitis...etc.) * with hallux valgus angle\>15° * with 1st metatarsophalangeal joint instability * 20\~40 y/o exclusion criteria: * lower extremities osteoarthritis * systematic diseases such as rheumatoid arthritis, systemic lupus erythematosus, dm...etc. * lower extremities fracture history * surgical history of lower extremities * neurological pathology that would interfere with gait * hallux could not be corrected to neutral through passive correction * low back pain and/or sacroiliac joint dysfunction in the past six months * excessive femoral anteversion

Keywords: patellofemoral pain syndrome runner first ray instability lower extremity closed chain exercise
incidence of large annular defects in primary lumbar discectomy patients

Conditions: Lumbar Disc Herniation; Anular Tear of Lumbar Disc; Nucleus Pulp Hernia;Lumbosac

Summary: lumbar discectomy study, collection and evaluation of incidence of large annular defects.

this study is designed as a single-site prospective data collection. measurements will be collected during 150 consecutive standard of care primary lumbar discectomy procedures.

Eligibility criteria:
inclusion criteria: 1. must be 18-75 years of age, and skeletally mature 2. must have clinical and radiological evidence of primary lumbar disc herniation at one level of the lumbar spine between l3-s1. 3. must be psychosocially, mentally and physically able to comply with protocol, post-operative management and follow-up care. 4. subject must understand and sign the written informed consent. exclusion criteria: 1. prior surgery at the index lumbar vertebral level. 2. subject requires spinal surgery other than a discectomy (with or without laminotomy) to treat leg/back pain 3. morbid obesity (bmi ≥ 40 kg/m2) 4. investigational drug or device use within 30 days
an evaluation of an adapted stepps group within forensic services

Conditions: Personality Disorder

Summary: the purpose of this study is to determine how effective the stepps-hi group is at improving emotional regulation skills in those with identified difficulties in this area within forensic inpatient services. in addition, to explore whether there is increased acceptability of the adapted stepps group (stepps-hi) for this client group.

systems training for emotional predictability and problem solving (stepps) is a manualised group programme for people primarily with a diagnosis of borderline personality disorder (bpd). although, stepps groups have been run within prisons in usa, it has been less formally evaluated within forensic psychiatric settings except for pipon-young \& cole (2012). taking the learning from these studies into account, significant adaptations to the current stepps manual are needed to increase the acceptability and applicability of the group within forensic settings. following the adaption of the stepps manual for a forensic inpatient population (stepps hi), this research aims to investigate how effective the group is at improving emotional regulation skills in those with identified difficulties in the area as well as whether there is increased acceptability of the adapted group for the participants. the outcome of the research is intended to provide feedback on the adaption of the stepps manual and also an evaluation of the revised programme.

Eligibility criteria:
inclusion criteria: * 18 years or older. * to give informed consent to participate in the study. * currently a resident in a low or medium secure unit. * has been diagnosed as meeting dsm-iv criteria for a personality disorder at some stage in their mental health history. * has identified difficulties with emotional regulation. * be willing and have suitable abilities to participate in a group. * to be assessed by the clinical team as sufficiently psychologically robust to participate in the group and the research. exclusion criteria: * psychiatric/psychological or any other difficulties that would mean that participants could not give informed consent. * intellectual/cognitive impairment which prohibits participants ability to consent or fully comprehend the study or study materials. * non-english speakers as there is no provision for interpreters. * unable to manage a group environment due to risk to self and others including bullying and violence (this will be assessed by the clinical and stepps-hi facilitation team. * no evidence of emotional regulation difficulties.

Keywords: stepps-hi personality disorder evaluation forensic