Kornimate/medical-research-clean huggingface dataset:
anthropometric measures and severity of gastroesophageal reflux disease

Conditions: Gastroesophageal Reflux Disease

Summary: evaluate the impact of different anthropometric measures on clinical and endoscopic severity of gerd and its relation to serum leptin.


Eligibility criteria:
inclusion criteria: * gastro esophageal reflux symptoms (e.g. heart burn, regurgitation, water brash or atypical symptoms such as hoarseness of voice, asthma and cough) * complete upper gastrointestinal endoscopy. exclusion criteria: * receiving medication for reflux disease (including proton pump inhibitor, histamine type 2 receptors blocker, prokinetic agents) in the previous month. * pregnant woman. * history of upper abdominal surgery. * severe co-morbidity as cirrhosis, end-stage renal disease and heart failure.

Keywords: gastroesophageal reflux disease; anthropometric measures; leptin
biomonitoring of internal exposure to mnpls, and its effects, in blood of patients with chronic kidney disease (ckd)

Conditions: Chronic Kidney Diseases; Microplastics; Nanoplastics; Genotoxic Damage

Summary: micro and nanoplastics (mnpls) effects on human heath is still preliminary. chronic kidney disease (ckd) participants, specially does patients submitted to hemodialysis, are a population high exposed to plastics. the objective of our research is to be able to detect mnpls on biological fluids of hemodialysis patients as well as their potential genotoxic and immunological damage.

the exponential increase in the production/use of plastic translates into a parallel increase of environmental plastic-waste that is continuously degraded into micro and nanoplastics (mnpls). information on the mnpls' effects on human health is still preliminary and, furthermore, the limitations in current methodologies prevent accurate human exposure/risk assessment. the study aims to analyse specific biomarkers of exposure to mnpls in humans, as well as biomarkers of genetic damage, which will allow an association between exposure to these plastic materials and the optimisation of different techniques for the detection and characterisation of mnpls. the study will evaluate the effect of exposure to mnpls, analysing the genotoxic damage, different biomarkers of exposure and the effects on microbiota, in different body samples (urine, blood and feces).

Eligibility criteria:
inclusion criteria for chronic kidney disease (ckd) submitted to hemodialysis: * participant submitted to hemodialysis for more than 3 months * between 18 and 85 years old * stable haemoglobin (more than 10 gr/dl) * absence of infectious disease at the date of sample collection and for a period of more than two weeks * absence of active neoplasia * stable vascular access inclusion criteria for chronic kidney disease (ckd) pre-dialysis: * no hemodialysis treatment * between 18 and 85 years old * stable haemoglobin (more than 10 gr/dl) * glomerular filtration ≤ 20 ml/min * absence of infectious disease at the date of sample collection and for a period of more than two weeks * absence of active neoplasia inclusion criteria for controls : * between 18 and 85 years old (paired by gender, age and lifestyle to the ckd patients) * absence of chronic kidney disease or dialysis treatment * absence of chronic pathology (including neoplasia) * absence of infectious disease at the date of sample collection and for a period of more than two weeks * spanish residence exclusion criteria for both groups of ckd patients: * clinical instability * life expectancy of less than 12 months * coagulation system disorders * participation in other clinical study * pregnancy * unsigned informed consent exclusion criteria for controls: * participation in other clinical study * pregnancy * unsigned informed consent

Keywords: ckd mnpls
modulation of ciliogenesis in glioma stem cells

Conditions: Glioblastoma; Glioma, Malignant

Summary: the study aims at investigating the cilium-related transcriptome in patients-derived glioblastoma stem cells and the potential impact of modulation of cilium players in vitro, in vivo and ex vivo in glioblastoma brain organoids. moreover, drugs inhibiting cilia disassembly will be tested. finally, the potential prognostic role of a cilium-related gene expression signature in glioblastoma will be assessed.


Eligibility criteria:
inclusion criteria: to be enrolled in the study patients must: 1. have a radiological diagnosis of supratentorial glioblastoma, or 2. have a radiological diagnosis of first recurrence of a primary supratentorial glioblastoma (for which a formal histopathologic diagnosis of glioblastoma had been made at first surgery), according with rano criteria (wen, 2010); 3. be a candidate to neurosurgery for glioblastoma at the operational unit of neurosurgery fpg; 4. be of an age of 18 years or above; 5. provide written informed consent for participation to the study. exclusion criteria to be enrolled in the study patients must not: 1. have not enough pathological material removed at surgery available both for mandatory routine histopathological diagnosis and for the present study, as judged by the principal investigator; 2. have not a definitive pathological diagnosis of a primary supratentorial gbm, according with 2016 who classification.

Keywords: cilia disassembly complex nek2 glioblastoma stem cells
biobank for ms and other demyelinating diseases

Conditions: Multiple Sclerosis; Transverse Myelitis; Neuromyelitis Optica; Acute Disseminated Encephalomyelitis; Optic Neuritis

Summary: to establish a large, longitudinal collection of high quality samples and data from subjects with ms, selected other demyelinating diseases (transverse myelitis (tm), neuromyelitis optica (nmo) or devic's, acute disseminated encephalomyelitis (adem), and optic neuritis (on)), and related and unrelated unaffected controls. samples and data will be available as a shared resource to scientists researching the causes, sub-types, and biomarkers of ms and related demyelinating diseases.


Eligibility criteria:
inclusion criteria: * age 18+ able to give informed consent or individuals younger than 18 with parental permission and able to give assent * willing to provide up to 110 ml (50 ml for \< 18 years old) of blood via venipuncture * experienced at least one cns demyelinating event characteristic of ms, tm, nmo, adem, or on exclusion criteria: * history of blood borne pathogens * allogeneic bone marrow transplant * clinical or radiological evidence of stroke, meningitis, or other well characterized diseases of the nervous system (with the exception of ms, tm, nmo, adem, or on). * weight less than 37 pounds

Keywords: multiple sclerosis clinically isolated syndrome transverse myelitis neuromyelitis optica acute disseminated encephalomyelitis optic neuritis repository biobank
the immediate effects of post isometric relaxation techniques

Conditions: Neck Pain

Summary: aim: the aim of this study is to investigate the immediate effects of post isometric relaxation (pir) technique on pain threshold, pain severity and joint range of motion of the cervical region in healthcare workers with neck pain. method: a total of 30 male and female participants aged 20-45 were randomly divided into two groups (post isometric relaxation (pir) technique and control group). pir group participants were under a single session of pir application with 10 repetitions to m.supraspinatus, the upper part of the m.trapeze and m.levator scapula in addition to classical swedish massage for neck and upper thoraric region. control group participants received only classical swedish massage to the cervical and upper thoracic region. pain severity (visual analog scale), pain threshold (digital algometer), range of servical motion (goniometer) were measured at baseline and immediately after the single-session pir techniques.

neck pain is the second most common musculoskeletal problem in the world after low back pain in terms of disability and health expenditures. occupational groups with the highest incidence of neck pain include those working in a hospital environment, office workers, and manual workers. post isometric relaxation technique (pir) is a muscle energy technique (met) and is used by physiotherapists to relax muscles, reduce pain and increase range of motion. the pir technique provides its neurological effects through autogenic inhibition, which results in relaxation in the agonist muscle by inhibiting contraction with the stimuli sent by the group ib fibers originating from the golgi tendon organ of the agonist muscle to the medulla spinalis during static stretching. the aim of our study is to investigate the instantaneous effect of pir technique on pain threshold, pain intensity and joint range of motion (neck flexion, extension, right and left rotation, right and left lateral flexion) in hospital workers with neck pain. this experimental study, which was planned as randomized and single-blind, was planned to be carried out with a total of 30 volunteer participants, male and female, working in a private hospital in istanbul between 7 october 2022 and 10 december 2022.

Eligibility criteria:
inclusion criteria: * be a hospital worker * complaining of neck pain for at least 3 months * pain intensity at rest is 4 out of 10 according to vas assessment * volunteer to participate in the study exclusion criteria: * having neck pain after trauma to the neck in the last 6 months * presence of neurological signs; neck pain that has spread to the arm and fingers * have had spinal surgery * shoulder pathology

Keywords: neck pain post isometric relaxation hospital employees pain threshold
comparison of architectural and performance adaptations of hip extension exercise under gravitational or inertial loading conditions

Conditions: Injury;Sports

Summary: the main objective of this study is to investigate training-induced adaptations in biceps femoris long head (bflh) architecture and performance measures such as muscle strength, jumping, and power variables after following 6 weeks of resistance training program with gravitational or inertial hip extension (he) exercise and a subsequent detraining period, comparing those adaptations with a control group. in addition, this study aims to determine the time course of bflh architectural adaptations throughout a 6-week training intervention.


Eligibility criteria:
inclusion criteria: * at least two years of resistance training experience * not have any injury, disease or pain that could reduce their maximal effort exclusion criteria: * history of injury to the lower limbs (including the hamstrings), wrist, or back in the past 18 months
evaluation of the wear of vitamin e treated polyethylene components in primary tha using rsa

Conditions: Osteoarthritis of Hip; Traumatic Arthritis of Hip

Summary: the specific aim of this proposed study is to conduct a prospective rsa clinical study at massachusetts general hospital involving 50 patients receiving primary total hip replacements. all patients will receive the vitamin e treated polyethylene acetabular inserts. short-term femoral head penetration and long-term steady state wear of the polyethylene will be measured using both rsa and martell analysis techniques. stability of the acetabular and femoral components will be measured in all patients using rsa analysis. the stability of the cemented femoral stems will be compared to the stability of the cementless femoral components as well as to historic data in the literature. in addition, all patients will complete a self-administered questionnaire to assess the clinical outcome of the surgery and patient satisfaction.


Eligibility criteria:
inclusion criteria: * male or female * 20 to 75 years of age * subjects requiring primary total hip replacement * subjects with diagnosis of osteoarthritis, avascular necrosis, or traumatic arthritis * subjects who demonstrate the ability to return to mgh for follow-up for the next five years. exclusion criteria: * subjects with limited life span * subjects with difficulty in comprehending study protocol for any reason. * subjects with inflammatory disease, previous infection or those requiring revision hip surgery. * subjects whose bony structures are so small that a femoral head less than 32mm in diameter must be used. * subjects whose bony structure deviates substantially from the general norm sufficiently to require non-standard techniques and non-standard implants. specific examples of these are total dislocation of the hip, severe coxa vera deformity, severe forms of multiple epiphyseal dysplasia * subjects with complex disease entities which significantly increase the risks of the surgery such as any major platelet abnormality, hematological disorder, positive for hiv or any other major medical complication which substantially reduces longevity. * female subjects that are pregnant or who may suspect they are pregnant or who plan to become pregnant while participating in this study.

Keywords: clinical outcomes radiographic outcomes total hip arthroplasty survivorship
inflammatory bowel disease (ibd) and covid-19 infection

Conditions: Inflammatory Bowel Disease

Summary: most of the inflammatory bowel disease (ibd: crohn's disease and ulcerative colitis) in a tertiary expert centre are on immunosuppressive and/or biological therapy. theoretically, these treatments may increase patients' risk of infection, in particular viral infection. therefore, the current sars-cov-2 pandemia, with its unprecedent worldwide morbidity and mortality, may have a negative impact on ibd patients' clinical course. identifying an increased risk in this particular patients' population as well as the risk/protective factors is of outstanding importance, in order to adapt their treatment and surveillance. as a consequence, our aims were (i) to measure retrospectively the risk of sars-cov-2 (proven by biological testing or suspected due to record of potential clinical symptoms of covid-19 infection) in this patients' cohort (principal objective), (ii) to identify risk or protective factors for sars-cov-2 infection in ibd, and (iii) to analyze the outcome of patients in case of suspected or confirmed covid-19. the results of this study may be important to adjust our surveillance and therapeutic strategy in these patients, in particular if high virus circulation will occur in the future.


Eligibility criteria:
inclusion criteria: * patient over the age of 18 years * ibd patients (crohn's disease, ulcerative colitis, indeterminate colitis) * patient agreeing to participate in the study exclusion criteria: * patient unable to understand the study protocol or to answer simple anamnestic questions due to language barrier * patient under guardianship or trusteeship * patient under safeguard of justice

Keywords: sars-cov-2 inflammatory bowel disease ibd crohn's disease ulcerative colitis immunosuppressant therapy biologicals severe respiratory disease intensive care unit mechanical ventilation death
study of the expression of met receptor fragments in non small cell lung cancers

Conditions: Non Small Cell Lung Cancer

Summary: our project, established through collaboration between clinicians (oscar lambret center-university hospital) and scientists (ibl), aims to evaluate the expression of met fragments in the lung cancer (lc). unlike previous studies on met by sequencing, in situ hybridization or immunohistochemistry, the investigators propose a protein analysis by western blot of tumor samples and healthy tissue. this approach will evaluate the expression of full-length receptor, the potential presence of intracellular fragments, and their phosphorylation status.

* patient information and collection of signed inform consent * blood sample collection before bronchoscopy or before surgery, at the same time as a usual blood assessment. * prospective collection of bronchial biopsies of patients with metastatic non small cell lung cancer, during a bronchoscopy at the oscar lambret center (dr dansin) * prospective collection of resected specimens of patients with localized non small cell lung cancer, who were operated at the thoracic surgery unit of the university hospital (pr porte) * transportation of the samples to the pathology laboratories (dr robin, pr copin) * selection of blocks of interest and preparation of tumor samples * clinical data collection : date of biopsy or surgery, disease-free survival, overall survival, tumor characteristics, egfr status, alk, braf, her2 * transportation of tumor blocks and blood samples to the institute of biology of lille for analyses: western blot, immunohistochemistry and elisa test) * return to storage of the tumor samples at the oscar lambret center and at the university hospital of lille

Eligibility criteria:
inclusion criteria: * patients with non small cell lung cancer (nsclc) * patients candidate for bronchial biopsies at the oscar lambret center (metastatic stage) or candidate for thoracic surgery at university hospital of lille (localized stage) * treatment naive patient for metastatic nsclc * patients with or without neoadjuvant therapy for localized nsclc * male or female patients aged ≥ 18 years * patient registered with the social security system * having signed a written informed consent exclusion criteria: * malignant tumors which are not carcinoma * small-cell malignant tumors * secondary bronchial lesions * revision surgery * pregnant or breastfeeding women * patient under guardianship or tutorship * previous cancer

Keywords: met fragments expression
study of gut microbiota diversity in children aged 1-3 years on prolonged antibiotic prophylaxis for grade 3 or higher vesicoureteral reflux compared with 2 age-matched control groups

Conditions: Vesicoureteral Reflux 3

Summary: urinary tract infections are very common in pediatrics. urinary antibiotic prophylaxis is commonly used in children with malformative uropathies. long-term, low-dose antibiotic prophylaxis with trimethoprim-sulfamethoxazole has been associated with a decrease in the number of urinary tract infections in susceptible children, but not systematically with a decrease in the risk of renal scarring (depending of uropathy stage). long-term antibiotic prophylaxis has implications for the acquisition of antibiotic resistance. a child receiving antibiotic prophylaxis for urinary tract infection is around 6 times more likely to develop a multidrug-resistant infection. in the general population, the microbiota of children treated with curative antibiotics is less diverse in terms of species and strains. in addition, short-term compositional changes are observed between consecutive samples of children treated with antibiotics. the gut microbiota modulates the immune system, in particular via metabolites (scfa, polysaccharide a) produced by bacteria that modify the expansion and function of regulatory t-cells. the disturbances of the intestinal microbiota play a role in the medium and long term on the acquisition of pathologies, such as atopy. the study authors wish to describe the intestinal microbiota of children with vesico-ureteral reflux treated long-term with trimethoprim-sulfamethoxazole and compared it those not receiving antibiotic prophylaxis and to healthy children.


Eligibility criteria:
inclusion criteria: * the patient must be a member or beneficiary of a health insurance plan * patient with no objection to participation in the study from the parent or guardian * child with a diversified diet. o specific inclusion criteria for group 1 (cases): * child with grade 3 or higher vesicoureteral reflux. * child on trimethoprim-sulfamethoxazole therapy for at least 5 months. o specific inclusion criteria for group 2 (controls): * child with uropathy and without long-term trimethoprim-sulfamethoxazole treatment. o specific inclusion criteria for group 3 (healthy controls): * child without uropathy or long-term trimethoprim-sulfamethoxazole treatment. exclusion criteria: * chronic digestive pathology * acute gastroenteritis or infectious colitis within last 15 days. * curative antibiotic therapy taken less than one month ago. * chronic inflammatory bowel disease or other localizations * congenital or acquired immune deficiency (current treatment with methotrexate, biotherapies, immunosuppressants) * patient participating in a category 1 trial likely to modify the intestinal microbiota. * patient in an exclusion period determined by another study. * patient under court protection, guardianship or curatorship. * patient for whom it is impossible to give informed information to person with parental authority.

Keywords: antibiotic prophylaxis microbiota
anterior shoulder dislocation

Conditions: Shoulder Dislocation

Summary: to compare and validate the two clinical algorithms

clinical decision rules have safely and successfully allowed clinicians to reduce the total number of radiographs ordered, while detecting patients with important pathology or injuries. the ottawa ankle and knee rules were developed from a series of studies, and have successfully reduced the number of radiographs ordered by physicians without missing serious ankle fractures (1-4). likewise, the nexus group developed a clinical decision rule for the selection of blunt trauma patients who are appropriate for imaging, based on clinical features (5). drs. hendey and emond have separately developed similar algorithms for selective radiography in patients with a suspected shoulder dislocation (6-10). the goal of the current study is to compare and validate the two clinical algorithms. both approaches examine clinical features that are readily accessible to the physician at the time of ed evaluation. in the pre-reduction assessment, both algorithms included the mechanism of injury and whether the patient had experienced a previous shoulder dislocation. hendey additionally assessed whether the physician was clinically confident of the dislocation (8). emond additionally included the age of the patient, and the presence or absence of humeral ecchymosis (9). in the post-reduction assessment, both algorithms emphasize the importance of clinical certainty of reduction, as well as the presence of a fracture dislocation.

Eligibility criteria:
inclusion criteria: * adult patients 18 years and older * patient with a suspected acute anterior shoulder dislocation exclusion criteria: * patients under 18 years of age * prisoners

Keywords: anterior shoulder dislocation shoulder dislocation shoulder pain shoulder deformity