Kornimate/medical-research-clean huggingface dataset:
a novel ballet-inspired low-impact at-home workout programme for adults with stroke

Conditions: Stroke; Gait, Unsteady; Balance; Distorted; Memory Impairment

Summary: to explore the feasibility of a novel ballet-inspired low-impact at-home workout programme for community-dwelling stroke survivors in hong kong.

a mixed methods exploratory study incorporating a randomised controlled trial (rct) and qualitative evaluation will be conducted. a total of 40 stroke participants will be recruited from two acute public hospitals. participants will be randomly assigned to receive the interention and usual care, or usual care only. data will be collected in multiple forms: recruitment/retention rates, adherence to the intervention, journals, field notes, verbal feedback, audio records, semi-structured interviews, and questionnaires on outcomes (balance, confidence in balance, gait, walking endurance). this study is the first of its kind in hong kong. findings will address the cross-cultural applicability of dance interventions and lay the groundwork for examination in a larger-rct about its effects on survivors' balance, gait and memory.

Eligibility criteria:
inclusion criteria: 1. aged 18 years or above 2. clinically diagnosed with a first-ever ischaemic/ haemorrhagic stroke 3. living in home settings 4. mild-moderate lower limb paresis with a modified functional ambulation classification (mfac) of iii (dependent walker) or above 5. a montreal cognitive assessment (moca) score\>20 6. able to follow three-step directions 7. able to communicate in cantonese and read traditional chinese 8. their hearing and/or visual disturbances corrected by hearing aids and/or glasses 9. consent to participate in the study exclusion criteria: 1. diagnosed with transcient ischaemic attack, subdural or epidural haemorrhage 2. experienced cerebrovascular events due to tumours or head trauma 3. have pre-existing neurological, cardiovascular or orthopaedic conditions that contradict participation in dancing such as shoulder dislocation, myocardial infarction, seizures or acutes illness 4. mental condition such as depression, schizophrenia or personality disorder 5. incomprehensible speech 6. severe hearing and/or visual disturbance
pleiotropy and mechanism of peripheral nerve related genes in the progression of amyotrophic lateral sclerosis

Conditions: Amyotrophic Lateral Sclerosis

Summary: this study will establish a comprehensive exon database of als patients, lay the foundation for screening the genes related to the occurrence and development of the disease, support the theory of als disease progression from peripheral to central, and reveal the correlation between the functional level of peripheral nerve and the prognosis of the disease at the gene level for the first time, and provide the basis for the mechanism research at the molecular level.

amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease that selectively invades superior and inferior motor neurons. because there is no effective treatment, it is urgent to find the risk factors of als to guide the prevention and slow down the disease progression. in the early stage of the disease, the peripheral motor injury is more rapid and sensitive than the central response, which is an ideal window to observe the state of the disease. protecting peripheral nerve integrity and maintaining its function can slow down the death of superior neurons, effectively relieve symptoms and prolong survival time, which has also been confirmed in patients with multiple stem cell-derived motor neurons and sod1 g93a disease model mice. reexamination of the role of peripheral motor nerve related factors in the development of als is of great significance for the study of disease mechanism, clinical classification, prognosis, evaluation of drug trial efficacy and individualized treatment plan. previous studies have shown that nefl gene, as the coding gene of light chain of neuron cytoskeleton, is closely related to axonal function, and its polymorphism is related to the occurrence and severity of axonal charcot marie tooth disease. exploring the role of similar peripheral nerve related genes in the progression of als will help us better understand the disease from the genetic level, establish an accurate and stable prognosis prediction model, and guide early treatment. this study will establish a comprehensive exon database of als patients, lay the foundation for screening the genes related to the occurrence and development of the disease, support the theory of als disease progression from peripheral to central, and reveal the correlation between the functional level of peripheral nerve and the prognosis of the disease at the gene level for the first time, and provide the basis for the mechanism research at the molecular level.

Eligibility criteria:
inclusion criteria: 1. since february 2021, he has been in the department of neurology, the third hospital of beijing medical university. he was diagnosed amyotrophic lateral sclerosis according to the revised ei escorial diagnostic criteria of 2004 edition, and the patients within one year of onset. 2. informed consent has been signed. exclusion criteria: 1. patients with als like syndrome caused by autoimmune diseases, paraneoplastic syndrome and simple demyelinating lesions were excluded.
development of a next generation sequencing (ngs) -based assay to detect preeclampsia molecular markers

Conditions: Preeclampsia

Summary: sample collection study

this is a limited prospective collection of whole blood samples from pregnant women with a diagnosis of preeclampsia with severe features and/or fetal growth restriction in addition to samples from a control group to aid in the development of a next generation sequencing (ngs)-based assay to detect molecular markers associated with preterm preeclampsia.

Eligibility criteria:
inclusion criteria: 1. women 18 years of age or older at enrollment 2. pregnant women with a viable singleton gestation 3. able to provide written, informed consent 4. able to provide 20 ml of whole blood 5. diagnosis of preeclampsia with severe features and/or diagnosis of fetal growth restriction. 1. preeclampsia with severe features is defined as: proteinuria: excretion of ≥300mg/24hr (24 hour collection) of protein or a timed excretion that is extrapolated to the 24 hour urine value or a protein/creatinine \[both in mg/dl\] ratio of at least 0.3 or a qualitative determination of (urine dipstick) of ≥1+ with systolic bp ≥160mmhg or diastolic bp ≥110mmhg on at least 2 occasions 4 hours apart while on bedrest but before the onset of labor or systolic bp ≥160mmhg or diastolic bp ≥110mmhg on 1 occasion but before the onset of labor, if antihypertensive therapy is initiated due to severe hypertension or new onset hypertension defined as: systolic bp ≥140 mmhg or diastolic ≥90 mmhg with one or more of the following features: thrombocytopenia (\ 1.1mg/dl or a doubling of serum creatinine in the absence of other renal disease); pulmonary edema; new onset cerebral disturbances or scotomata 2. fetal growth restriction defined as: estimated fetal weight by ultrasound at ≥ 19 0/7 weeks gestational age \ 95%ile for gestational age, absent end diastolic flow or reverse end diastolic flow) 6. gestational age between 20 0/7 and 33 6/7 weeks determined by ultrasound and/or lmp per acog guidelines1. a subject diagnosed with preeclampsia without severe features prior to 33 6/7 weeks gestation and who is managed expectantly and develops severe features after 34 weeks may be included. exclusion criteria: 1. known malignancy 2. history of maternal organ or bone marrow transplant 3. maternal blood transfusion in the last 8 weeks 4. chronic hypertension diagnosed prior to current pregnancy 5. type i, ii or gestational diabetes 6. fetal anomaly or known chromosome abnormality 7. active labor

Keywords: preeclampsia fetal growth restriction
effects of leader sleep improvement on leadership

Conditions: Insomnia, Primary; Chronic Insomnia

Summary: the purpose of the study is to investigate the effects of sleep improvement in leaders on leader outcomes.

the investigators seek to extend the findings of a recent research which demonstrated that treating insomnia has several beneficial effects on employee work outcomes (barnes, miller, \& bostock, in press). in the present study, the investigators propose that the treatment of leader insomnia would beneficially influence leadership, specifically abusive supervision, charismatic leadership, and laissez-faire leadership.

Eligibility criteria:
inclusion criteria: * working adults who have at least one direct report (i.e., subordinate). exclusion criteria: * non-working adults/ adults who do not have at least one direct report (i.e., subordinate).
brain plasticity in carpal tunnel syndrome and its response to acupuncture

Conditions: Carpal Tunnel Syndrome

Summary: this study will characterize brain plasticity in carpal tunnel syndrome and will determine how this central fmri biomarker is modulated by acupuncture. this study will also investigate the behavioral consequences of maladaptive cortical plasticity in this disease population.


Eligibility criteria:
inclusion criteria: 1. male and female adults aged 20-60. 2. history * pain and/or paresthesia in median nerve distribution (i.e., numbness in some combination of digit 1, 2, 3, and the radial part of digit 4) * nocturnal pain and/or paresthesia in median nerve distribution * symptoms (a and b) greater than 3 months in duration 3. physical exam with two of the following three findings: * phalen's and durkin's sign (positive with paresthesia in at least 1 of 3 radial digits) * abnormal grip strength (greater than 2 s.d. compared to uninvolved side using an isometric hand grip device) 4. nerve conduction findings consistent with mild to severe cts: mild cts: delayed distal latency of the sensory nerve conductions across the wrist (\> 3.7milliseconds and/or \> than 0.5 milliseconds compared to the ulnar sensory conduction) with normal motor conductions moderate cts: delayed distal latency of the sensory nerve conductions across the wrist as stated above with delayed distal latency of the motor conductions across the wrist (\> 4.2 milliseconds). severe cts: delayed distal latency of the sensory nerve conductions across the wrist as stated above with greater than 50% loss of motor amplitudes (relative to unaffected side and/or normative range). exclusion criteria: 1. contraindications to mri examination (pregnancy, pacemaker, etc. according to guidelines set by mgh nmr-center) 2. history of diabetes mellitus or other major cardiovascular, respiratory, or neurological illnesses. 3. history of rheumatoid arthritis. 4. history of wrist fracture with direct trauma to median nerve. 5. current usage of prescriptive opioid pain medication. 6. severe thenar atrophy. 7. nerve entrapment other than median nerve. 8. cervical radiculopathy or myelopathy. 9. generalized peripheral neuropathy. 10. a blood dyscrasia or coagulopathy or current use of anticoagulation therapy
effects of an early wheelchair reconditionong program on functional independence in spinal cord-inured individuals

Conditions: Spinal Cord Injuries

Summary: reconditioning program during the chronic phase of the spinal cord-injury is well known for its beneficial effects, but there is no investigation in early rehabilitation consequences. nevertheless, it may be justified : to increase oxygen uptake; to decrease the risks of medical complications; or to improve the mobility. the restrictive autonomy is due to different factors: firstly wheelchair users reduce their movement because they need technical or human help to achieve transfers; and secondly, locomotion is performed by the upper limbs. without specific practice, the upper limbs mechanical and physiological properties do not permit exercises that are long and intense. then, the purpose of this research is to evaluate the effects of an 8 weeks interval training program on wheelchair independance during inpatient early rehabilitation for spinal cord injury (3 to 6 months post injury) compared to a control group (classical rehabilitation program in a physical medicine and rehabilitation department).


Eligibility criteria:
inclusion criteria: * acute spinal cord injury (sci) from trauma , medical or surgical pathology at levels between c7 and l1. * categories a or b as defined by the american spinal injury association (asia) impairment scale * male or female * 18 to 60 years old. * no ability to walk independently with or without an assistive device * 3 to 6 months post-sci in early phase of rehabilitation in a physical medicine and rehabilitation unit. * subject affiliated to a social security regime and registered at the healthcare department * written informed consent obtained from each subject exclusion criteria: * symptomatic syringomyelia that may complicate the evaluation procedures * disabled pathology before the sci * cardiopulmonary disease, degenerative disorders, upper limb disorders, bones inury or other significant medical complications that would prohibit or alter compliance with a wheelchair training protocol. * psychological incapacity to follow a training protocol during 8 weeks. * surgery or intrathecal injection planned. * reject to give written informed consent.

Keywords: early reconditioning program spinal cord injury early rehabilitation wheelchair
epidemiological characteristics and prognosis factors of cancer patients admitted at french emergency departments

Conditions: Cancer Patients; Emergencies

Summary: patients with cancer or hematological malignancy are susceptible to present acute complications linked to their disease or to their specific treatments (dyspnea, sepsis, coma, hemorrhagic syndrome). emergency physicians are in first line when these complications arise and have to face with some complex situations in which informations about patient malignancy or prognosis may be lacking. nowadays, there is very few epidemiological data published concerning how cancer patient use emergency departments (eds) and cancer patient care delivery in the eds. thus, an observational multicenter prospective cross-sectional study is conducted to study the prevalence of cancer patients admitted to french eds, and to describe the different reasons for cancer patients to seek care in eds with their prevalence and underscore those linked to cancer or treatment complication


Eligibility criteria:
inclusion criteria: * adult patients (age \>=18 years) * with active malignancy or a history of cancer in remission within the last 5 years * being attended in one of the 400 french emergency centers participating in the study during the 3-day study period exclusion criteria: * opposition to participate

Keywords: cancer emergency departments (ed)
does mindfulness enhance bmi in obese adolescents enrolled in the bright bodies weight management program?

Conditions: Pediatric Obesity

Summary: participants will be randomized to an evidence-based healthy lifestyle program alone or a healthy lifestyle program with mindfulness meditation added. the purpose of the study will be to determine if mindfulness improves bmi outcomes more than the program alone due to the stress-reduction benefits of mindfulness.

the study will randomize 44 adolescents (aged 11-17 yo) with bmi \>95th percentile to traditional bright bodies healthy lifestyle program or lifestyle program plus mindfulness meditation (6 sessions within the 12-week program) (22 per group). the traditional program includes exercise two evenings per week and nutrition/behavior modification one evening per week for 12 weeks. mindfulness session topics include breathing meditation, body scan meditation, mindful eating techniques, and identification of hunger verses satiation. the primary outcome measure with be (1) bmi, while secondary outcomes include changes in (2) percent body fat, (3) perceived stress scale (questionnaire), (4) physical stress (saliva cortisol levels), and (5) overall caloric intake (pre and post food records). after the 3 month intervention, participants will engage in post measures and be asked to return 6 months later (9 months) for longer-term follow-up measures.

Eligibility criteria:
inclusion criteria: * bmi \>95th percentile for gender \& age * english-speaking subject and parent/caregiver * parent/caregiver willing to participate in weight mgt program exclusion criteria: * bmi \>40 \<27 * psychiatric disorder or medical condition that precludes participation in program * currently taking medication that causes weight gain or loss * involvement in co-existing weight management program * a positive pregnancy test * plans on moving out of the greater new haven area within 9 months

Keywords: pediatric obesity, stress
prevention of acute pancreatitis after endoscopic interventions

Conditions: Cholangiolitis; Acute Pancreatitis

Summary: the aim of the study is to develop a method for the prevention of acute pancreatitis after minimally invasive interventions of the bile ducts using a drug regimen.

a prospective, randomized, single-center study is planned to identify the most effective drug regimen in order to prevent the development of acute pancreatitis after transpapillary interventions of the bile ducts.

Eligibility criteria:
inclusion criteria: 1. patients with cholangiolithiasis. 2. patients with benign formations of the bile ducts. 3. patients with malignant formations of the bile ducts. 4. patients with extrahepatic bile duct cysts. 5. patients with biliary hypertension of unknown etiology. 6. patients with cholangitis. 7. patients with extrahepatic bile duct strictures. 8. patients suffering from oncopathology of the head of the pancreas, complicated by obstructive jaundice. 9. patients with malignant pathology of the pancreas. 10. patients with benign pancreatic pathology. exclusion criteria: 1. asa scale\> iii (severe concomitant cardiovascular pathology) 2. severe pathology of the respiratory system. 3. acute period of myocardial infarction. 4. acute period of cerebral infarction.

Keywords: cholangiolithiasis, endoscopic, acute pancreatitis, cholangiography
topical hydromorphone for wound healing

Conditions: Wound Healing

Summary: the hypothesis is that topical opioids will hasten wound healing in humans.

this is based on our published data that morphine is a powerful stimulant of angiogenesis and our preclinical study of wounds in rats which demonstrate that topical opioids (morphine, hydromorphone and fentanyl) hasten healing of punch biopsy wounds. this study will focus on hydromorphone which was more powerful than morphine as a wound-healer in the rat study.

Eligibility criteria:
inclusion criteria: * self-identified as normal, healthy volunteers age 18-65. exclusion criteria: * known bleeding disorder.
clinical efficacy of a new piezoelectric technique for wisdom teeth extraction

Conditions: Impacted Third Molar Tooth

Summary: the aim of this randomized controlled clinical study is to evaluate the efficacy of a new piezoelectric technique for wisdom teeth extraction without using manual tools versus the conventional one.patients referred to the hospital of bolzano for wisdom tooth extraction will be randomly divided in two groups. in the test group all the procedure will be performed using piezoelectric instruments, while in the control one conventional manual instruments will be used. main outcome measures are patient pain and complications, secondary outcome measures are duration of the surgical treatment and soft tissue healing

wisdom teeth extraction can be difficult and patient can suffer post operative swelling and pain. a new piezoelectric technique for wisdom teeth extraction was developed and it showed promising results in terms of surgical effectiveness and patients post operative complications. the aim of the study is to compare the new technique with special designed piezoelectric tools with the traditional one in a randomized controlled way. the same procedures are to be followed for teeth extraction except for the use of a piezoelectric lever in one group and a manual lever in the other one. the study is a mono-center, pragmatic, randomised clinical trial (rct) of parallel group design. the trial would have one week follow up. all patients referred to the dental department of s.maurizio hospital (bolzano, italy) for the extraction of wisdom teeth are considered eligible for the study.

Eligibility criteria:
inclusion criteria: * patients referred for wisdom tooth extraction * patients older than 18 years old and able to sign the informed consent exclusion criteria: * general contraindications to surgery. * patients irradiated in the head and neck area. * immunosuppressed or immunocompromised patients. * patients who took or are taking bisphosphonates intravenously. * uncontrolled diabetes * presence of oral pathologies that seriously involved oral mucosa * patients with poor oral hygiene and motivation. * patients with oral pathologies with serious mucosal involvement * pregnancy or lactation. * addiction to alcohol or drugs. * psychiatric problems. * patients with an acute infection inflammation around the tooth to be extracted. * wisdom teeth with roots attached or positioned around the nerve * patients unable to come to the required follow up visits

Keywords: wisdom teeth extraction piezoelectric technique
analyzing the effect of trunk training on limbs in children with spastic cerebral palsy

Conditions: Cerebral Palsy, Spastic

Summary: the purpose of this study is to analyze if trunk training has effects on trunk, upper, lower extremity motor functions in children with spastic cerebral palsy. second purpose is to analyze the relation between trunk control and prematurity, birth weight, upper and lower extremity motor functions in children with spastic cerebral palsy.

cerebral palsy (cp) is a condition caused by a lesion occurred in immature brain during prenatal, natal or postnatal period. children with cp may have motor, cognitive, sensory, auditory, behavioral problems during their lifespan. spastic type cp is most common type of cp and many children with spastic cp have both trunk and limb impairment. physiotherapy is very important for improving motor function and protect from secondary impairments in this children and should start as early as possible. the aim of this study is to analyze if trunk training has effects on trunk, upper and lower extremity motor function in children with spastic cp. 38 children with spastic cp between 4-18 years age are included in this study. both genders are included. the participants randomized according to their gross motor function classification system levels and their age. before intervention all groups assessed with assessment tools which assess muscle spasticity, balance, gross motor function, trunk control and walking characteristics. after randomization there wasn't any intervention for control group; they continued their regular physiotherapy in special education centers two times a week. study group received trunk training two times a week in addition to their regular physiotherapy in special education centers during 8 weeks. after 8 weeks all groups assessed with the same assessment tools.

Eligibility criteria:
inclusion criteria: 1. children with spastic cerebral palsy effected bilaterally 2. between 4-18 years age exclusion criteria: 1. received orthopedic surgery during last 6 weeks 2. receive botulinum toxin injection during last 6 weeks 3. mentally retarded children with communication limitations 4. had epileptic seizures during last 12 moths -

Keywords: trunk training motor function
changes of bone metabolic markers and bone mineral density after denosumab and/or teriparatide treatment in japanese osteoporotic patients

Conditions: Osteoporosis

Summary: it has not been well known about the changes of bone metabolic markers, bone mineral density and other bone-related markers after teriparatide and/or denosumab treatment in japanese osteoporotic patients.


Eligibility criteria:
inclusion criteria: * osteoporotic patients exclusion criteria: * none