Kornimate/medical-research-clean huggingface dataset:
qigong and exercise therapy for low back pain in adults

Conditions: Low Back Pain

Summary: the purpose of this study is to assess the effectiveness of qigong for the treatment of low back pain compared to a stabilizing exercise therapy.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of chronic low back pain since at least 3 months and complaints for a maximum duration of 5 years * low back pain more prominent than other pain in the spine * average pain intensity of the last 7 days more or equal to 40 mm measured by a visual analogue scale (vas 0 - 100 mm) * intellectual and physical ability to participate in the study * informed consent exclusion criteria: * low back pain related to malignancy * low back pain due to an accident * inflammatory joint disorders * previous spine surgery * protrusion/prolapse of a spinal disk, spondylolisthesis, with radicular symptomatology * actually doing or planning to do other regular physical exercise during the study with possible positive effects on low back pain - such as swimming, yoga, pilates, tai chi, etc. * planning to do another therapy during the study with possible positive effects in low back pain, such as physiotherapy, acupuncture, massage, spinal manipulation etc. * use of pain drugs for other diseases (\> 1x/week) * pregnancy * severe chronic or acute disease interfering with therapy attendance * alcohol or substance abuse * participation in another clinical trial in the last 6 months before study entry

Keywords: qigong traditional chinese medicine exercise therapy low back pain
myofascial massage in the treatment of chronic low back pain

Conditions: Chronic Low Back Pain

Summary: the purpose of the study is to determine the effectiveness of an approach that combines massage therapy with elements of neurocognitive rehabilitation such as motor imagery and the words of the physiotherapist compared to a traditional massage therapy in reducing pain in patients with chronic low back pain (clbp) and to evaluate if and how the pain reduction is linked to the interoceptive awareness and which is the patient's ability to relax through the measurement of the hearth rate variability (hrv).


Eligibility criteria:
inclusion criteria: * presence of chronic nonspecific low back pain for at least three months * subjects aged between 18 and 50 years exclusion criteria: * presence of acute low back pain * low back pain due to other causes (vertebral fractures, spondylolisthesis, herniated discs, lumbar canal stenosis) * disorders of central and/or peripheral nervous system * systemic inflammatory disease (eg rheumatoid arthritis) * systemic infectious disease * neoplastic disease * previous surgery * cognitive impairment * pregnancy

Keywords: low back pain interoceptive awareness motor imagery massage
evaluation of the probiotic lactobacillus coryniformis k8 on covid-19 prevention in healthcare workers

Conditions: Covid-19

Summary: the aim of the present study is to evaluate the effects of lactobacillus coryniformis k8 consumption on the incidence and severity of covid-19 in health workers exposed to the virus. this is a preventive study


Eligibility criteria:
inclusion criteria: 1. persons over 20 years of age. 2. active healthcare personnel, who attend patients with covid-19 disease, including all professional categories, medicine, nursing and warders. 3. ability to complete surveys. 4. signature of informed consent exclusion criteria: 1. person with positive test of covid-19 confirmed by pcr test or serology 2. person with concomitant pathology hiv, transplant, active oncology or other type of active immunosuppression 3. pregnant women or women with intention to become pregnant in the next 2 months.

Keywords: covid-19 prevention healthcare workers
efficacy of acupuncture on chronic pelvic pain in women with endometriosis or adenomyosis

Conditions: Endometriosis; Adenomyosis; Pelvic Pain

Summary: the purpose of ths study is to determine the efficacy of acupuncture on chronic pelvic pain in women with endometriosis or adenomyosis.

chronic pelvic pain(cpp) is a common disease among women, and its prevalence ranges from 4 to 25 percent. there are various conditions associated with cpp, including gynecologic, urologic and gastointestinal problems. endometriosis is the most common diagnosis made at the time of gynecological laparoscopy performed to evaluate cpp. treatments of cpp with endometriosis include medical(analgesics, oral contraceptive pills, gonadotropin releasing hormone(gnrh) agonist, etc.), surgical and combined treatment. progestins, danazol, estrogen-progestin pills, or gnrh agonists are commonly used as a concurrent treatment along with surgery. however, a systematic review on the comparison of postsurgical hormonal suppression to surgery alone concluded that, while postoperative medical therapy decreased recurrence rates, there was no significant benefit on the outcomes of pain and pregnancy rates. therefore there is a need for postoperaive medical therapy for pain relief. in this study, the investigators propose a randomized, sham-controlled trial to investigate the efficacy of acupuncture as a pain control for the patients dignosed endometriosis during laparoscopic surgery due to cpp, and have been on 6 month-scheduled gnrh agonist treatment as a postoperative treatment.

Eligibility criteria:
inclusion criteria: * patients diagnosed pathologically of endometriosis or adenomyosis among those who had undergone laparoscopic surgery due to pelvic pain * patients who have been on gnrh agonist treatment for 6 months after being diagnosed endometriosis or adenomyosis * patients who agreed a written consent by their own will * patients' compliance and geographical adjacency appropriate for proper follow up survey * continuous pelvic pain over vas 5 during past 1 week on screening visit(after 6 weeks of surgery) (0='no pain', '10=most severe') exclusion criteria: * those who had taken hormones or drugs that can affect diagnosis of endometriosis or adenomyosis for past 1 year * patients found to have malignant tumor of uterus and adenexa, pid or pregnancy during surgery * allergies to metal or contraindications for acupuncture treatment (ex: coagulopathy, epilepsy) * unable to participate in clinical trial by doctor's judgment * irritable bowel syndrome

Keywords: acupuncture
a research trial of high dose vitamin c and chemotherapy for metastatic pancreatic cancer

Conditions: Pancreatic Neoplasms

Summary: this study is designed to determine the maximum tolerated dose of vitamin c when given with a standard chemotherapy for people who have metastatic pancreatic cancer.

this is a phase i, dose-escalating study of ascorbic acid (vitamin c) designed to determine the maximum tolerated dose of vitamin c or, if well tolerated, the dose required to obtain a desired ascorbic acid plasma concentration. because this is a phase i study, prospective subjects should have advanced disease (i.e., metastasis) and have failed other curative therapies (or, are unable to receive curative therapies due to comorbidities or stage of disease).

Eligibility criteria:
inclusion criteria: * normal g6pd status * histologically or cytologically diagnosed pancreatic adenocarcinoma. * disease extent documented by ct scan (radiologically measurable disease is not required) * ambulatory patient without evidence of spinal cord compression * no prior chemotherapy for metastatic disease * failed curative therapy or patient ineligible for definitive curative therapy * completed adjuvant therapy at least 4 weeks prior and recovered from any/all toxicities related to that treatment. * if post-therapy, must have disease progression since that treatment * if treated with prior radiation therapy, disease must be outside of the radiation fields * no currently active second malignancies unless it is a non-melanoma skin cancer * women must be non-pregnant and non-lactating * ecog performance of 0, 1, or 2 * granulocytes at least 1,500 / ul * platelets at least 100,000 / ul * creatinine less than 1.5 mg/dl or clearance of at least 60 ml / min * total bilirubin less than 2 times the upper limit of normal * ast and alt less than 3 times the upper limit of normal if liver metastases are not present. if liver metastases are present, ast and alt less than 5 times the upper limit of normal * pt inr less than 1.5 (unless the patient is on full dose warfarin) * patient must be at least 18 years of age * patient must be able to understand consent process, the research study, and be able to sign the consent document exclusion criteria: * a psychiatric disorder by history or examination that would prevent completion of the study * ecog performance of 3 or 4 * co-morbid conditions that affect survival: end stage congestive heart failure, unstable angina, myocardial infarction (within the past 6 weeks), uncontrolled blood sugars of greater than 300 mg/dl, known chronic active hepatitis or cirrhosis. * consumption of excess alcohol (more than 4 drinks per day) or use of illicit drugs * continued sse of over-the-counter antioxidants (supplements like vitamin c and grape seeds)

Keywords: ascorbic acid gemcitabine
safety and performance evaluation of the autolap system

Conditions: Patients Scheduled for Hernia Repair, Cholecystectomy, Right Colectomy, Nissen Fundoplication and Sigmoid Resection

Summary: the main objectives of this study are to evaluate the safety and performance of the autolap system in laparoscopic cholecystectomy procedures.


Eligibility criteria:
inclusion criteria: 1. signed and dated informed consent form. 2. patients between 18 and 75 years of age inclusive who were scheduled for elective laparoscopic cholecystectomy procedure. exclusion criteria: 1. previous upper abdominal surgery and contraindications to pneumoperitoneum. 2. pregnancy. 3. obesity (bmi \>35 kg/m2). 4. generalized peritonitis. 5. septic shock from cholangitis. 6. severe acute pancreatitis. 7. uncorrected coagulopathy. 8. previous abdominal operations which prevent safe abdominal access or progression of the procedure. 9. advanced cirrhosis with failure of hepatic function. 10. suspected gallbladder cancer. 11. acute cholecystitis 12. presence of any medical or psychiatric condition or any other condition that, in the opinion of the investigator, could affect the successful participation of the patient in the study. 13. patient participates in any other clinical study 60 days prior to the start of the study and throughout the study duration.

Keywords: laparoscopic cholecystectomy gallbladder removal laparoscope holder
evaluation of a new silicone hydrogel contact lens

Conditions: Myopia

Summary: the objective of this study is to determine the clinical feasibility and to evaluate the product performance of investigational contact lenses developed by bausch + lomb.


Eligibility criteria:
inclusion criteria: * have physiologically normal anterior segments not exhibiting clinically significant biomicroscopy findings. * be adapted wearers of soft contact lenses, wear a lens in each eye, and each lens must be of the same manufacture and brand. exclusion criteria: * have worn gas permeable (gp) contact lenses within last 30 days or polymethylmethacrylate (pmma) lenses within last 3 months. * any systemic disease affecting ocular health. * using any systemic or topical medications that will affect ocular physiology or lens performance. * an active ocular disease, any corneal infiltrative response or are using any ocular medications. * any "present" finding during the slit lamp examination that, in the investigator's judgment, interferes with contact lens wear. * allergic to any component in the study care products.

Keywords: contact lens
grip effects of power ball in children

Conditions: Visual Impairment

Summary: a broad definition of visual impairment includes a wide continuum of visual function loss. aspects of visual function include visual acuity, which is the capacity to resolve detail, and accommodation (capacity to concentrate), field of vision (the area that may be seen), colour perception, and light sensitivity. a child with cerebral blindness can nevertheless be able to perceive motion. there are numerous sources of prevalence information, each of which has drawbacks. one of the fundamental pillars of the major worldwide prevention of blindness project, vision 2020 the right to sight, is the reduction of visual impairment and blindness in children in resource-poor nations. refraction and poor vision services aid visually impaired children, especially those with genetic or congenital ocular defects and enable vision improvement.

visual impairment is a broad term that describes a wide continuum of loss in visual function. there are many aspects of visual function e.g., visual acuity(ability to resolve detail),accommodation (ability to focus), field of vision (area which can be seen), colour vision and adapt ability to light. a child with cerebral blindness may have intact perception of movement. prevalence data can be obtained from a variety of different sources, each of which has limitations. reducing visual impairment and blindness in children in resource-poor countries is one of the key components of the major global prevention of blindness initiative, vision 2020 the right to sight. visually impaired children especially with hereditary /congenital ocular anomalies benefit from refraction and low vision services which facilitate vision enhancement and inclusive education. pediatricians have a key role in early detection and multidisciplinary management to minimise the impact of visual impairment (vi) in childhood.visually impaired children especially with hereditary /congenital ocular anomalies benefit from refraction and low vision services which facilitate vision enhancement and inclusive powerball® is such a market existing device that can be used for wrist rehabilitation and also as a sports aid for strengthening the wrist. the powerball acts as an eccentric exercise tool, generating forces in different directions and thus causing stimulation of the forearm, hand, and wrist musculature. the tools used will be handheld dynamometer and pegboard test. study will be conducted on twenty eight patients in two groups. .group a will be control group that will be provided with conventional physiotherapy (isometric hand grip training exercises) and group b will be experimental group that conventional treatment with power ball training. data will be analyzed using spss 22.0

Eligibility criteria:
inclusion criteria: * age ranging from 8 to 14 years, * both genders (male /female) exclusion criteria: * serious medical conditions such as cardiac disease, diabetes, or uncontrolled seizures * significant shoulder, elbow, or * wrist joint contractures preventing grip movement of the hand and fingers. * unable to follow the command * orthopedic surgery, neurological surgery
tongzhou cohort study

Conditions: Obesity; Hypertension

Summary: the present study aimed to investigate the impact of obesity on long-term cardiovascular risk in elderly patients with hypertension.

overweight status and obesity are important risk factors leading to hypertension, poor blood pressure control, and poor prognosis. however, the studies focused on elderly patients with hypertension are limited. therefore, the aim of the present study was to evaluate the long-term impact of obesity on cardiovascular risk in elderly patients with hypertension.

Eligibility criteria:
inclusion criteria: * ages of ≥ 60 years * history of hypertension and treatment with anti-hypertension drugs for more than 4 weeks * availability for follow-up until 2026 * no major barriers to provide written consent exclusion criteria: * na

Keywords: obesity hypertension cardiovascular risk
infective endocarditis after tavr

Conditions: Infective Endocarditis of Aortic Valve

Summary: this study aims at studying the frequency of infective endocarditis after transcatheter aortic valve replacement/implantation

since the start of transcatheter aortic valve implnatations/replacements (tavr/tavi) implantations in sweden in 2008 all procedures have been added to a national database, which now contains 4500+ procedures. at the same time, all admissions to the hospital is also recorded with diagnosis in a separate database. we intend to make a nation-wide complete follow up of all tavr/tavi patients in swede that has received the diagnosis of infective endocarditis after the implantation. in addition data will also be collected from the national endocarditis database for detailed information of the cases.

Eligibility criteria:
inclusion criteria: all patients that has under tavr/tavi in sweden between 2008 and 2018 exclusion criteria: patients unable to follow up due to emigration or missing social security number
preimplantation genetic testing for aneuploidies in patients with recurrent implantation failure

Conditions: Recurrent Implantation Failure

Summary: assessing whether preimplantation genetic testing for aneuploidy (pgt-a) can increase the ongoing pregnancy rate per transferred embryo and can decrease the time to pregnancy and miscarriage rate in patients with recurrent implantation failure (rif)


Eligibility criteria:
inclusion criteria: * women with recurrent implantation failure (previous transfer of least 4 good quality embryos in at least 3 fresh or frozen cycles) * bmi \< 35 * normal hysteroscopy exclusion criteria: * thin endometrium in previous cycles (\<6mm), endometriosis asrm score iii-iv, premature ovarian failure (pof, bologna criteria), abnormal karyotype, donor oocytes or embryos, pgt-m
a multicentre clinical investigation of a decision support algorithm for neonatal seizure detection

Conditions: Seizures; Brain Diseases; Central Nervous System Diseases; Epilepsy; Nervous System Diseases; Neurologic Manifestations

Summary: the anser clinical investigation is a multi-centre, randomised, controlled, clinical investigation of a standalone decision support algorithm for neonatal seizure recognition, the anser software system.

this will be an open, two arm, parallel group, randomised, controlled investigation of the anser software system as a stand-alone neonatal seizure recognition decision support tool. term neonates requiring eeg monitoring will be stratified by recruiting site and then randomised to receive either eeg monitoring with the anser software system or eeg monitoring without the anser software system. it is proposed that the rate of true detections (sensitivity) of investigation personnel using the anser software system in clinical practice will be at least 25% higher than that of investigation personnel not using the anser software system in routine clinical practice. in addition we expect the specificity of investigation personnel using the anser software system to be no worse than 10% less than that of investigation personnel not using the anser software system. this should result in more appropriate and timely use of antiepileptic drugs (aed). randomisation immediately following enrolment in the investigation, each participant will be randomly assigned to receive either eeg monitoring with the anser software system or without the anser software system. randomisation will be stratified by recruiting site with a 1:1 allocation ratio to each group. block randomisation with varying block sizes will be used and the randomisation and allocation will be performed centrally using a web-based electronic system. blinding as this is an investigation of a medical device (software), the investigation personnel will be aware of which group the participant is assigned to. the expert panel who are the diagnostic reference standard will be blinded to group allocation. the biostatistician will also be blinded to group allocation during the analysis of the data.

Eligibility criteria:
inclusion criteria: * neonates 36 weeks - 44 weeks corrected gestational age in whom eeg monitoring is indicated because they are deemed to be * at high risk of seizures or * are experiencing seizures exclusion criteria: * • no parental/guardian consent

Keywords: neonatal seizures decision support algorithm eeg
integrated care approach for rheumatoid arthritis patients

Conditions: Rheumatoid Arthritis (RA)

Summary: the goal of this study is to learn about the long-term effects of integrated care approach in persons over the age of 20 who take part in integrated care approach to treat their rheumatoid arthritis (ra). the main question is to explore whether adding the integrated care approach into routine care can lower pro-inflammatory cytokines and depressive symptom in ra persons over age 20 when taken long-term to treat ra?


Eligibility criteria:
inclusion criteria: age of at least 20 years; willingness to participate in the survey; having the physician-diagnosed ra with the international classification of diseases, 9th revision, clinical modification code of 714.0 exclusion criteria: * having physician-based diagnosis of cognitive impairment and with the ability to express opinion
discharge planning for elderly patients in the emergency department: use of a brief phone call after discharge to improve medication utilization and physician follow-up

Conditions: Patient Discharge

Summary: the investigators hypothesize that the acquisition and correct utilization of medications as well as arranging and attending follow-up appointments will improve as a result of a phone call intervention 1-3 days after elderly patients are discharged from the emergency department (ed).

older patients seen in the ed are at high risk of functional decline and return visits to the ed. previous studies have shown that a comprehensive assessment by a geriatric specialist at the time of discharge from the ed along with extensive integration with home services and/or referral to community services can decrease functional decline and return visits to the ed as well as increase patient satisfaction, but this intervention is resource intensive requiring a geriatric discharge specialist to be available to the emergency department 24 hours a day/ 7 days a week. it is also known that in other patient populations telephone reminders to make follow up appointments can increase rate of follow up and that comprehension of discharge instructions is the primary barrier to compliance with discharge instructions. it has been shown that telephone follow-up interviews are feasible for geriatric patients discharged from the ed, and that many elderly patients discharged from the ed do not understand their discharge instructions or attend follow-up appointments. however, there are no published studies evaluating whether a follow up telephone call after discharge from the ed can improve patient compliance with the medical treatment plan including obtaining follow - up appointments and obtaining prescribed medications as well as using them appropriately. we seek to determine if we can increase compliance with medications and outpatient follow up with a phone call from a nurse provider 1-3 days after discharge.

Eligibility criteria:
inclusion criteria: * age 65 or over * discharged from the unc emergency department exclusion criteria: * in the hospital at the time of phone call follow-up * neither the patient nor their responsible party are able to pass a standardized test to assess cognitive function

Keywords: emergency medicine primary care physicians