Kornimate/medical-research-clean huggingface dataset:
effectiveness of teleorientation in oral hygiene during the covid-19 pandemic

Conditions: Dental Caries in Children

Summary: the present study aims to evaluate the effectiveness of teleorientation in oral hygiene during pandemic by covid-19 in children aged 6 to 10 years, attended at the pediatric clinic of forp. for this, a randomized clinical study will be carried out with the factor to be analyzed the comparison between synchronous and asynchronous teleorientation, the effectiveness of the transfer of knowledge in oral hygiene through video modeling and remote guidance. the response variables will be the assimilation of oral hygiene guidance through video modeling and synchronous guidance, the hypothesis is that educational content will have beneficial effects on children's oral health.

this is a randomized clinical trial, whose sample is composed of thirty children aged 6 to 10 years, attended between the year 2019 and the beginning of 2020. the sample will be randomly randomized into 3 groups who received guidance on toothbrushing. group 1 will be done teleorientation of tooth brushing through video call by the whatsapp application, in group 2 will be done teleorientation of toothbrushing through a platform designed exclusively for teleconsultations and group 3 will receive the same in-person brushing orientation. the main purpose of the clinical trial is to develop and analyze a program of teleorientation of toothbrushing in children of the pediatric dentistry clinic of forp. the specific objectives are assess whether oral hygiene is taking place properly during the covid-19 pandemic, assess, through a questionnaire, the level of understanding of parents and caregivers regarding the information received. this project will be designed as a randomized study with a two-month follow-up. the study factor will be to compare synchronous with asynchronous teleorientation, the effectiveness of knowledge transfer in oral hygiene through video modeling and remote orientation. the response variables will be the assimilation of guidance in oral hygiene by video modeling and by synchronous guidance, the hypothesis is that educational content will have beneficial effects on the oral health of children. the procedures will be performed at the pediatric dentistry clinic of the faculty of dentistry of ribeirão preto - university of são paulo - forp/usp. the consort guide (schulz et al., 2010) for randomized controlled trials will be followed for the design of the present study.

Eligibility criteria:
inclusion criteria: * children aged 6 to 8 years old, * attended at forp's pediatric dentistry clinic, * with complete record in the medical record, * parents or caregivers who have smartphone and internet access * and who are willing to download the v4h and * whatsapp application and * accept to participate in all stages of the research upon acceptance of the consent form. exclusion criteria * :children who present pain and/or spontaneous sensitivity, * motor difficulties and * health disorders .

Keywords: ehealth, mobile health
examining the effects of core stabilization exercises and myofascial release technique in individuals with chronic neck pain: a randomized clinical trial

Conditions: Neck Pain

Summary: chronic neck pain is a musculoskeletal disorder that affects people frequently in life. postural control is based on the process of correctly identifying and selectively focusing the incoming afferent input of the central nervous system (cns). the main treatment options for people with neck pain include soft tissue and joint mobilizations, stabilization exercises for the neck, trunk and shoulder muscles, cervical deckings, relaxation training, strengthening exercises and body awareness and posture training. in this study, it was aimed to investigate the effects of myofascial relaxation on balance, pain, joint range of motion and functionality in individuals with chronic neck pain by dividing them into two groups in the form of core stabilization and core stabilization and myofascial relaxation. the study included 45 people between the ages of 18 and 65. in two groups, the core stabilization group will be 22 people, and the core stabilization and myofascial relaxation group will be 23 people. the study period is planned as 6 weeks and 3 sessions per week.


Eligibility criteria:
inclusion criteria: * having neck pain that has been going on for at least three months * the mean pain intensity according to the visual analog scale (gas) is moderate \[4-6.9 centimeters (cm) * december\] or be at a severe (7 cm and above) level * to be between the ages of dec 18-65 * to be literate and to be a writer * volunteering to participate in the study exclusion criteria: * having severe degenerative arthritis * having a neurological finding due to spinal root compression (positive upper limb stretching tests,cervical compression test) * to have a finding due to pressure of the spinal cord (positive l'hermitte sign, babinski sign) is * having undergone cervical spine surgery * having a cervical neck fracture and/or joint subluxation/dislocation * having osteoporosis and/or neck pain due to a tumor * having a history of primary malignancy * being pregnant * the title refers to neurological disease (parkinson's, multiple sclerosis, etc.) * having received physiotherapy and rehabilitation in the last three months

Keywords: balance functionality myofascial relase
effects of rosa damascena and frankincense essential oils in labor

Conditions: Labor Pain

Summary: this randomized controlled study aims to compare effects of different essential oils in labor pain, anxiety and childbirth comfort. the main questions it aims to answer are: is it effective using rosa damascena oil during labor? is it effective using frankincense oil during labor? which essential oil is more effective during labor researchers will compare aromatherapy oils groups to see labor pain, anxiety and childbirth comfort levels of pregnant women.

during childbirth; pain, anxiety, and comfort level of women have a critical importance for a positive childbirth experience. so this study aims to compare the effects of different essential oils on labor pain, anxiety and labor comfort. in some studies, rosa damascena was found effective for labor pain. however, there are limited studies about comfort level and anxiety level of women during labor. so we aimed to investigate whether rosa damascena oil was effective for labor comfort and anxiety level or not. samely it will be investigated frankincense oil was effective for labor comfort and anxiety level or not. also which essential oil was more effective during labor will be analyzed.

Eligibility criteria:
inclusion criteria: - pregnant women who are at latent phase of labor exclusion criteria: * complicated pregnancy (preeclampsia, hypertension, diabetes etc.) * women who will have planned cesarean section * asthma or any other respiratory disease * allergies to rosa damascena or frankincense oil

Keywords: aromatherapy childbirth problems rosa damascena frankincense comfort
effectiveness of treatment for relational aggression in urban african american girls

Conditions: Aggression

Summary: this study will evaluate the effectiveness of a school-based social cognitive group treatment in reducing aggression (bullying) among relationally aggressive urban african american girls.

relational aggression, also known as "female bullying," is a type of psychological aggression in which covert tactics are used to harm other people and their relationships. these tactics include humiliation, intimidation, coercing, shaming, malicious teasing, shunning, and using other forms of emotional abuse in an attempt to harm others. although aggressive behavior is typically common among younger children, most children become less aggressive as they mature and develop better interpersonal skills. however, consistent aggressive behavior can lead to further problems and increased violence in the aggressor. in this study, a social cognitive anger management group intervention called friend to friend (f2f) will be evaluated as a way to develop more productive social and emotional functioning among relationally aggressive urban african american girls. participants will be randomly assigned to either the f2f program or a psycho-educational attention control (pac) group. all participants will attend 40-minute treatment sessions twice a week for a total of 10 weeks. the sessions will occur during the girls' lunch or recess period. participants assigned to the f2f program will learn how to identify signs of physiological arousal, react to a potential conflict while generating alternatives to the solution, and apply previously discussed social cognitive strategies to different situations. culturally specific cartoons, videotape illustrations, and role playing will be used to portray these improved strategies and behaviors. participants assigned to the pac group will learn different organization and homework strategies as well as how to improve their study skills in an attempt to improve their overall academic performance. outcomes will be assessed through observation, school reports, and questionnaires for all participants at baseline, immediately after treatment, and 9 months after treatment.

Eligibility criteria:
inclusion criteria for schools : * urban school located in southwest philadelphia * student body is more than 80% african american * large school with at least three classrooms per grade * not currently involved with systematic anti-aggression social skills program inclusion criteria for participants: * in the 3rd, 4th, or 5th grade * meets diagnostic criteria for relational aggression exclusion criteria for participants: * enrolled in special education and not integrated into a regular education classroom

Keywords: social skills anger management relational aggression
individualizing antidepressant treatment using pharmacogenomics and ehr-driven clinical decision support

Conditions: Depression

Summary: the purpose of this study is to understand the effectiveness of pharmacogenomic testing in using antidepressants and to understand how ehr - driven clinical decision support system can be used to deliver pgx test results by healhcare providers.


Eligibility criteria:
inclusion criteria: patients who quality the criteria below: * patients with nonpsychotic mdd * patients who would like to either start a new antidepressant or change their existing antidepressant treatment * patients for whom antidepressant treatment is deemed appropriate by the treating clinician * \>18 years of age * willingness to provide signed informed consent to participate in the study * will be following up or continuously visiting their physician providers: * outpatient practice providers * providers who are familiar with epic exclusion criteria: patients: * patients with medical contraindications that preclude antidepressant treatment * patients with schizophrenia, schizoaffective disorder, or who have bipolar i disorder * patients currently on antipsychotic medications (e.g., typical and atypical antipsychotic drugs) and mood stabilizing agents (e.g., lithium, carbamazepine, valproate, lamotrigine, gabapentin, or other anticonvulsants) * patients who are pregnant or have severe cognitive impairment * patients requiring urgent care or inpatient hospitalization at the time of consent providers: • unable or unwilling to commit time to introduce mygenes study to patients
impact of insulin on sympathetic nervous system-mediated peripheral vasoconstriction

Conditions: Vasoconstriction; Healthy; Insulin Resistance

Summary: the purpose of this project is to determine if hyperinsulinemia attenuates sympathetic nervous system-mediated vasoconstriction in the human leg.


Eligibility criteria:
inclusion criteria: * healthy adult men and women; * 18-45 years of age; * bmi 18-30 kg/m2; * non-pregnant/non-breastfeeding; * non-nicotine users; exclusion criteria: * taking any medications known to affect metabolic, respiratory, cardiovascular, and/or autonomic functions self-reported history of: * hepatic, renal, pulmonary, cardiovascular, or neurological disease; * stroke or neurovascular disease; * bleeding/clotting disorders; * sleep apnea or other sleep disorders; * diabetes; * smoking; * history of alcoholism or substance abuse, excessive alcohol consumption; * hypertension; * active cancer; * autoimmune disease; * immunosuppressant therapy
effectiveness of contingency management in the treatment of crack addiction in brazil

Conditions: Substance Use Disorders; Contingency Management; Addiction, Cocaine

Summary: crack addiction has become a severe public health problem in brazil. crack users present elevated prevalence rates of psychiatric comorbidities, sexual transmitted infections and unemployment with high probability of living or have lived in the streets, history of incarceration and engagement in illegal activities. for the last 20 years a treatment called contingency management (cm) have achieved the best results regarding reduction of substance use, promotion of abstinence, treatment attendance and retention in treatment. the first cm study conducted in brazil advocates for the efficacy of cm on all of these outcomes, suggesting that cm can be effective in a brazilian population of crack users.

the objective of this study is to evaluate the effectiveness of contingency management (cm) for crack users living in the "crackland" region. to achieve this goal, regular treatment staff from unidade recomeço helvétia treatment service will be capacitated in cm to latter-on apply the cm intervention in their respective services. the design will be a single-blind randomized clinical trial composed of a sample of 100 subjects with current diagnose for crack/cocaine dependence. participants allocated to the control condition will receive 12 weeks of the usual care treatment provided by these two treatment facilities. participants allocated to the experimental condition will receive the exact same treatment as control participants associated with cm. cm procedure will occur 2 timer per week (every monday and thursday or tuesday and friday). primary outcomes are: (1)retention in treatment; (2) reduction of crack use; (3) promotion of continuous crack cocaine abstinence. secondary findings are reduction on psychiatric symptomatology. the investigator hypothesis is that participants in the cm condition will have a better treatment response in all studied outcomes.

Eligibility criteria:
inclusion criteria: * dsm-v diagnose for crack cocaine use disorder exclusion criteria: * being under 18 years old

Keywords: crack cocaine contingency management ambulatory treatment brazil
train your brain - executive function

Conditions: Overweight and Obesity

Summary: the purpose of this research is to test if playing games designed to improve an individual's executive function can change their views about the types of foods they eat. executive function is a set of mental processes that people use every day to make decisions - such as what kinds of foods they choose to eat and when and where they eat those foods.

the purpose of this study is to determine whether executive function (ef) training concurrently improves attitudes, perceptions, and consumption of nutrient-dense foods (i.e., fruits, vegetables) while worsening the same of nutrient-poor foods. in effect, the aim is to test whether ef training can promote the substitution of nutrient-poor foods with fruits and vegetables (fv), as the dietary guidelines for americans (dga) recommends regular consumption of fv as part of a healthy dietary pattern. given the health benefits associated with consuming fv, ef training that effectively promotes increased fv intake may benefit health. for example, fv consumption is associated with the reduced risk of all-cause mortality, cardiovascular disease, diabetes, cancer, and eye and skin health. moreover, fv consumption is associated with better mental and cognitive health.

Eligibility criteria:
inclusion criteria: * bmi 23-38 kg/m2 * us citizenship * not currently dieting to lose weight and no weight loss or gain of \>2 kg over the past 3 months * no tobacco or e-cigarette use * not pregnant or lactating or planning to become pregnant while participating in the study exclusion criteria: * not a us citizen * currently dieting to lose weight * weight loss of \>2 kg over the past 3 months * tobacco or e-cigarette use * pregnant or lactating or planning to become pregnant while participating in the study * a history of bariatric surgery * diagnosis of major medical or psychiatric condition that would interfere with participation, including not being physically able to play the games, or a current eating disorder

Keywords: normal weight
pegfilgrastim for stem cell mobilization in children (meg-5)

Conditions: Solid Malignancies

Summary: hypothesis : pegfilgrastim at 200 µg/kg between 12 and 18 days after previous chemotherapy provides an efficient stem cell mobilization in children with malignancies design: phase 2 study. judgment criterion: percentage of children achieving at least 5x10e6 cd34 cells with a standard apheresis (less than 3 blood volume processed

patients: consecutively referred for hsc mobilization. 12 to 18 days after the previous chemotherapy. no haematological growth factor during the 8 previous days. mobilization: one sc injection of 200 µg/kg pegfilgrastim (neulasta, amgen) evaluation during the study: cd34 circulating cells from day 3 to day 7 ; ae recording judgment criterion: percentage of children achieving at least 5x10e6 cd34 cells with a standard apheresis (less than 3 blood volume processed) analysis: sequential bayesian study

Eligibility criteria:
inclusion criteria: * 0 to 18 years * solid malignancy * lansky score \>70% * 12 to 18 days since the beginning of the last chemotherapy cycle * no administration of any hematopoietic growth factor in the previous 8 days exclusion criteria: * clinical or biological conditions precluding the mobilization or collection procedure

Keywords: children cancer bone marrow transplantation stem cell mobilization g-csf children with solid malignancies
secondary bypass banding for weight regain or weight loss failure after lap. gastric bypass

Conditions: Morbid Obesity

Summary: this is an observational study on the efficacy of the secondary placement of the a.m.i soft gastric band in weight regain or weight loss failure after lap. gastric bypass.


Eligibility criteria:
inclusion criteria: * weight regain of more than 10 kg from nadir * excessive weight loss of less than 50% at 18 months after laparoscopic gastric bypass exclusion criteria: * formerly leak at the gastrojejunostomy * formerly open abdominal surgery * anastomotic ulcer

Keywords: weight regain weight loss failure gastric bypass
assisting pulmonary disease diagnosis with ophthalmic artificial intelligence technology

Conditions: Pulmonary Diseases; Ophthalmological Diagnostic Techniques; Artificial Intelligence

Summary: this study intends to collect ophthalmologic examination results, pulmonary examination results and related indexes from patients with pulmonary disease and control populations, and combine big data analysis and artificial intelligence technology to explore whether new methods can be provided for early screening strategies for pulmonary disease with the aid of ophthalmologic examination, and thus assist in identifying the types of pulmonary disease and determining disease prognosis.


Eligibility criteria:
inclusion criteria: * those aged ≥18 years; or those aged \<18 years who can cooperate with the relevant examination and are accompanied and informed by a guardian; * people with respiratory-related diseases who were to undergo pulmonary examination, or those who volunteered to participate in the trial through publicity recruitment; * expected survival time of 3 months or more; * those with no previous serious underlying disease and no history of serious eye disease; * those who can cooperate with ophthalmologic and pulmonary-related examinations and have regular follow-up examinations; * those who gave informed consent to the study prior to the trial and voluntarily signed the informed consent form; * other conditions that can be included in the study as judged by the investigator. exclusion criteria: * patients who are unable to complete ophthalmology or pulmonary-related examinations and regular follow-ups due to serious diseases, trauma or surgery (serious ophthalmology diseases such as extremely poor vision that cannot be fixed, ocular atrophy, severe refractive interstitial clouding that prevents fundus photography, etc.); * people with poor compliance due to various reasons such as alcohol or drug dependence, or mental disorders; * those without informed consent; * other conditions judged by the investigator to be unsuitable for participation in the trial.

Keywords: pulmonary diseases ophthalmological diagnostic techniques artificial intelligence
maintenance oral vinorelbine or observation after vinorelbine-docetaxel first line chemotherapy in advanced breast ca

Conditions: Breast Cancer

Summary: this 2 arms study will assess the efficacy and safety of the vinorelbine-docetaxel combination given as an initial upfront treatment (first line) to all metastatic breast cancer patients enrolled. patients having a disease control following initial treatment, will be randomized to either oral vinorelbine maintenance arm or observation arm. the trial will also compare the efficacy and safety of maintenance oral vinorelbine versus observation.

to our knowledge, this is the first trial evaluating the role of oral vinorelbine as a maintenance therapy versus observation following a first line treatment with iv/oral vinorelbine+docetaxel. eligible patients will be enrolled in the trial to receive 6 cycles of iv(d1)/oral(d8) vinorelbine + docetaxel. for responding and sd patients, after the 6 cycles, they will be randomized either in observation arm or to receive a maintenance chemotherapy with oral vinorelbine. the oral form of the drug was found to be most appropriate for a long term treatment allowing to preserve qol of the patients. oral vinorelbine will be administered on d1, d8 every 3 weeks during maintenance treatment, until pd, unacceptable toxicity or patient refusal to continue. the trial will assess efficacy/safety of initial vinorelbine-docetaxel combination as well as the benefits of maintenance chemotherapy with oral vinorelbine.

Eligibility criteria:
inclusion criteria: * written informed consent * patients \>=18 years of age * histologically or cytologically confirmed adenocarcinoma of the breast that is now metastatic or locally-recurrent and inoperable with curative intent * measurable and/or non-measurable disease * the patient's primary and/or metastatic tumor is her2 neu negative * documented metastatic disease previously untreated with palliative chemotherapy * adjuvant or neo-adjuvant chemotherapy (including treatment with docetaxel or any other chemotherapy) is allowed with a disease free survival of at least 6 months * no symptom or sign of brain metastasis exclusion criteria: * operable local recurrence * ascites or pericardial effusion as only site of metastasis * symptomatic peripheral neuropathy \> grade 1 according to the nci common toxicity criteria * radiotherapy to all areas of evaluable disease within the previous 4 weeks * disease significantly affecting absorption * severe hepatic insufficiency * patient previously treated with chemotherapy for their metastatic disease

Keywords: oral vinorelbine oral chemotherapy metastatic breast cancer advanced breast cancer maintenance treatment