Kornimate/medical-research-clean huggingface dataset:
development and prospective validation of a digital pathology-based artificial intelligence diagnostic model for pan-cancer lymphatic metastasis

Conditions: Cancer; Lymphatic Metastasis

Summary: the goal of this diagnostic test is to develop an artificial intelligence (ai)-based pan-cancer universal diagnostic model for detecting pathological lymph node metastasis (lnm), and prospectively evaluate its apllication value in the real-world clinical practice. investigators will compare the diagnostic performance (sensitivity, specificity, etc.) of the ai model and routine pathological report issued by pathologists, to see if the ai model can improve the clinical workflow of pathological evaluation of cancer lnm in in the real world.

lymph node metastasis (lnm) is a common mode of cancer metastasis, and accurate postoperative pathological lymph node staging is of great significance for further treatment and prognosis assessment. however, the current pathological evaluation of lymph nodes relies on manual examination by pathologists, which has a relatively low diagnostic efficiency and is prone to missed-diagnosis for micro metastatic lesions. therefore, investigators are to develope an artificial intelligence (ai)-based diagnostic model for detecting pathological cancer lymph node metastasis based on deep learning algorithms, and evaluate its apllication value in the real-world clinical settings. this study is a diagnostic test with no intervention measures, planning to collect pathological slides of formalin-fixed, paraffin-embedded lymph nodes resected from the enrolled patients and digitise them into whole-slide images (wsis). the ai model will analyse the wsis and generate pixel-level heatmaps and slide-level diagnostic results (with or without lnm). the routine pathological examination will be performed as usual. these two processes will not interfere with each other. and if there are inconsistency in slide-level classification between ai and routine pathological examination, investigators would convene senior pathologists for discussion to make the final decision (immunohistochemistry would be performed if necessary). the final result will be presented to the patient in the form of a pathological report.

Eligibility criteria:
inclusion criteria: * patients with cancer, undergoing radical tumor resection and lymph node dissection. * patients with complete clinical and pathological information. exclusion criteria: * the patient refused to participate in this diagnostic test.

Keywords: artificial intelligence lymph node metastasis digital pathology whole slide image
examination of trends in multiple myeloma trial patient experiences

Conditions: Multiple Myeloma

Summary: historically, participation in clinical trials has been highly skewed towards specific demographic groups. however, research identifying which trial attributes impact participation, in either positive or negative ways, is limited. this study invites participants to record a wide range of data on their clinical trial experience, with the goal being to identify factors which persistently limit patients' ability to participate in, or complete, a trial in which they were initially interested. data will be analyzed through a range of demographic lenses, in hopes of discovering patterns which might improve the experience of future multiple myeloma patients.


Eligibility criteria:
inclusion criteria: * aged ≥ 18 years old and ability to provide written informed consent obtained prior to participation in the study and any related procedures being performed * patient has been diagnosed with multiple myeloma * subjects willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examination. exclusion criteria: * inability to perform regular electronic reporting * patient does not understand, sign, and return consent form * pregnant, breastfeeding or expecting to conceive within the projected duration of the study

Keywords: multiple myeloma
propofol effect-site target controlled infusion in the obese: characterization of the time profile of bispectral index response

Conditions: Obesity

Summary: the aim of this study is to characterize the pharmacokinetic/pharmacodynamic relationship of a single bolus dose of propofol in obese patients and to extract a time to peak effect (t-peak) from the estimated model parameters.

target controlled infusion (tci) is a technique to administer intravenous drugs that allows rapid achievement and maintenance of predetermined drug concentrations, either in plasma (cp) or at the site of effect (ce). to characterize the time profile of propofol effect an additional parameter, the equilibration half time between plasma and effect site (t1/2keo) needs to be incorporated in the pharmacokinetic (pk) model.

Eligibility criteria:
inclusion criteria: * imc \> 35 kg m-2 * scheduled for laparoscopic bariatric surgery * asa i-ii patients * between 20 and 60 yr of age. exclusion criteria: * patients with allergy to study drugs * uncontrolled hypertension * heart block greater than first degree * take any drug acting in the central nervous system

Keywords: anaesthetics iv propofol pharmacokinetics pharmacodynamic
cyanide poisoning in fire victims

Conditions: Carbon Monoxide Poisoning

Summary: aim: to determine the incidence of cyanide poisoning in fire victims. 20 consecutive patients will have the rest of their blood sample analyzed for cyanide.


Eligibility criteria:
inclusion criteria: * age 18 years or older * exposed to smoke from fire and admitted to hospital exclusion criteria: none
influence of the education in layperson in out of hospital resuscitation

Conditions: Cardiac Arrest, Sudden; Heart Arrest

Summary: cardiac arrest occurs frequently and the outcome after out-of-hospital resuscitation is often fatal. disturbing is that more than half of the surviving patients suffer from permanent impairment of cognitive functions, such attention, memory and executive functioning. with all the efforts to achieve a high quality initial resuscitation management the time delay between cardiac arrest and the beginning the initial resuscitation maneuver is the main reason for the still poor outcome. to shorten this fatal time delay, current efforts of national and supranational health authorities aime at the non-medically trained lay person, who should carry out basic life support directly on the scene supported by the use of public available semi-automatic defibrillators (aed).

it is a combined retrospective and prospective observational single center study. data of all out of hospital patients suffered a cardiac arrest in zurich city will be collected according to the utstein criteria. the aim of this study is to investigate the impact of trained police forces in the resuscitation outcome.

Eligibility criteria:
inclusion criteria: * all out of hospital patients suffering cardiac arrest in zurich city, resuscitated by lay persons, city police and or trained emergency medical services exclusion criteria: * individuals with cardiac arrest occurring in the presence of ems * individuals in whom there were apparent toxic, traumatic or suicidal etiologies for unconsciousness * drowned individuals and individuals with terminal illness * documented negation of data collection

Keywords: first responder bls aed resuscitation
an open label pharmacokinetic study of gabapentin in japanese subjects with renal impairment including hemodialysis

Conditions: PK Properties Of Gabapentin In Subjects With Impaired Renal Function

Summary: to confirm the pharmacokinetics following administration of gabapentin to japanese subjects with renal impairment, compare the results to western study results and confirm the adaptive possibility of dose adjustment in us package insert to japanese.

the study was terminated on september 30, 2008 at the current study site due to reported adverse events in the study subjects (n=8). while the adverse events reported were generally consistent with the known profile of gabapentin, it was decided that the study should continue at a different study site. the pharmacokinetics of gabapentin in the subjects with renal impairment will be evaluated in a separate study with a different study number at a different site. the study will be entitled: "the pharmacokinetic study of gabapentin in japanese epileptic subjects with renal impairment".

Eligibility criteria:
inclusion criteria: * the subjects whose creatinine clearance is 5-59 ml/min, or hemodialysis patients. * the hemodialysis patients who enter this study is required hemodialysis for at least six weeks (the frequency is three times per week) exclusion criteria: * renal allograft recipients

Keywords: gabapentin pharmacokinetics, renal impairment
frequency of hepatobilliary manifestations in patients with inflammatory bowel disease

Conditions: Hepatobilliary Manifestations in Inflammatory Bowel Disease Patients

Summary: hepatobilliary manifestations as extraintestinal manifestations of ibd are sometimes underdiagnosed which can impair patient prognosis

non alcoholic fatty liver is aliver disease most commonly found in patient with ibd most commonly without intestinal activity. on the other hand primary according cholangitis is the most common specific with ibd commonly with ulcerative colitis. and is commonly overlap with autoimmune hepatitis ibd therapy can also be a cause it can lead to hepatic toxicity and some drugs like ant tnf can cause hepatitis b virus activation.

Eligibility criteria:
inclusion criteria:all patients diagnosed ibd crohns and ulcerative on conventional treatment and biological treatment - exclusion criteria:no -
status of surgical resection and histologic subtype as predictors of local recurrence in retroperitoneal liposarcoma

Conditions: Liposarcoma of Soft Tissue; Surgical Procedure, Unspecified

Summary: soft tissue sarcomas are rare malignant tumors. liposarcoma constitute the most frequent histological subtype of retroperitoneal sarcoma. the prognosis of soft tissue sarcomas depend on clinical and histologic characteristics. objective: evaluate variables that may be related to overall survival and local recurrence free survival in patients with retroperitoneal liposarcoma. methods: retrospective analysis of medical records of 60 patients attended from 1997 to 2017, who underwent surgical resection of retroperitoneal liposarcoma.


Eligibility criteria:
inclusion criteria: * all patients who underwent surgical resection of retroperitoneal liposarcoma exclusion criteria: * unresectable disease (upper mesenteric artery or vein involvement) or metastatic disease (sarcomatosis or distant disease)

Keywords: retroperitoneal liposarcoma overall survival local recurrence free survival
ambien cr for treatment of insomnia associated with depression when used concomitantly with lexapro

Conditions: Insomnia

Summary: to demonstrate overall improvement of insomnia in subjects treated with zolpidem tartrate extended-release (ambien cr) and escitalopram (lexapro) vs. subjects treated with placebo and escitalopram at 2 months.


Eligibility criteria:
major inclusion criteria: 1. must experience sleep disturbances at least 3 nights/week, based on historical data 2. must meet the diagnostic requirements for major depressive disorder 3. must have qids-sr16 score between 6 and 15 4. must be either newly diagnosed or show symptoms of relapse/recurrence of depression while not on medication 5. age 21-64, inclusive 6. women must use a medically acceptable form of contraception (steroidal contraceptive, double-barrier, or intra-uterine device) during the entire study period, or: be surgically sterilized, post-menopausal, agree to use double-barrier contraception throughout the study period, or must have a negative urine pregnancy test prior to randomization. 7. subject must be stabilized on all ongoing long-term medication therapy for at least 28 days prior to screening visit. major exclusion criteria: 1. severity of depressive episode had been rated as "severe" or "severe with psychotic features." 2. history of a suicide attempt or suicidal ideation. 3. history of mania, manic episode or bipolar disease. 4. currently using a benzodiazepine or ssri or more than 2 days of use within the 28 days preceding randomization. 5. use of prescription and non-prescription sedative drugs given for the purpose of sleep induction or to relieve jet lag 6. any abnormal pre-study laboratory values that require clinical intervention 7. prior failure to respond to escitalopram therapy for depression 8. current depressive episode requiring inpatient hospitalization. 9. shift work or requirement for a regular change in sleep schedule by at least six hours within the previous 28 days. 10. history of drug addiction, alcoholism, or drug abuse. 11. a positive urine drug screen for medication that would interfere with the assessment of the study medication. 12. known allergy to zolpidem, escitalopram or any of their excipients 13. history of sleep apnea 14. history of myasthenia gravis 15. the presence of any untreated or uncompensated clinically significant renal, endocrine, gastrointestinal, hepatic, respiratory, cardiovascular, other neurologic, hematologic, oncologic, immunologic, cerebrovascular disease or malignancy. 16. pregnant or breastfeeding 17. subject is participating in another clinical trial, or has completed another clinical trial within 28 days prior to screening.
pilot behavioral support intervention after bariatric surgery

Conditions: Obesity

Summary: prospective, randomized pilot trial to evaluate a comprehensive postoperative behavioral support intervention using a 4-month bi-weekly program in 40 bariatric surgery patients (all surgical procedure types) from the geisinger health system center for nutrition and weight management compared to 40 usual care patients.

bariatric surgery patients may experience significant psychosocial changes after surgery, but little psychological support is available beyond support groups postoperatively. psychosocial changes after surgery, including mood fluctuations, interpersonal issues and substance use, have the potential to lower quality of life and interfere with adherence to the postoperative diet and lifestyle, diminishing weight loss outcomes. this prospective randomized pilot trial will evaluate the effect of a postoperative support program targeting quality of life, psychosocial functioning and adherence to behavior change in geisinger health system (ghs) bariatric surgery patients. in this study there will be two arms. the intervention arm will include forty bariatric surgery patients (all procedure types) from the ghs center for nutrition and weight management (cnwm) who will participate in a four month bi-weekly postoperative behavioral support program to address psychosocial changes after surgery, strategies for postoperative diet and adherence and preventing weight regain. the control arm will include 40 usual care (uc) patients from the same center that completed bariatric surgery within one year. both groups will complete two sets of surveys. the first set will be administered at study initiation. the second set will be administered upon completion of the 8 sessions for the intervention group. the control group will also complete surveys during this same timeframe (approximately 4-6 months after baseline survey completion). upon study completion, control group members will be afforded an opportunity to participate in the same postoperative behavioral support program offered to the intervention group. the primary endpoint of this study will be quality of life with secondary endpoints including differences in psychosocial functioning (mood, eating behaviors) and adherence (diet, physical activity, appointments) as well as patient satisfaction, treatment feasibility and attrition.

Eligibility criteria:
inclusion criteria: * bmi\>35 kg/m2 at time of surgery * primary bariatric surgery completion \< 1 year * understanding of informed consent exclusion criteria: * pregnancy * revision of bariatric surgery * significant cognitive impairment that prevents informed consent
elastography in boys with epididymo-orchitis

Conditions: Epididymo-orchitis

Summary: the patients treated in our clinic for epididymoorchitis will be given scrotal shear wave elastography by the department of radiology and affected testis will be compared to non affected testis radiologically. shear wave elastography is a method of ultrasonography, which allows the focused ultrasonographic wave to be directed to the selected tissue to produce deformation of the tissue and to obtain the numerical data on the tissue elasticity by measuring the speed of the wave when the tissue is recovered. the higher the wave velocity, the lower the elasticity of the tissue. the data to be obtained by this method will be compared statistically.

epididymo-orchitis is an inflammatory disease of the epididymis and / or testis. the clinical picture is manifested by sudden onset testicular pain and swelling. the differential diagnosis of testicular torsion should be made in the pediatric age group. while urgent surgery is required in testicular torsion, treatment with epididymo-orchitis consists of antiinflammatory and cold application. scrotal ultrasonography is used in the differential diagnosis and epididymo-orchitis is diagnosed in epididymis. the scrotal ultrasound for the control after the patient's symptoms have regressed gives an idea about the course of the inflammatory process. in recent years, the introduction of elastography, which is an advanced ultrasound technique, has begun to suggest the evaluation of the elasticity of testis and epididymis in various scrotal diseases. in epididymo-orchitis, a disease that is known with inflammation of the testicular parenchyma, a study evaluating whether there is a permanent change in the testicular parenchyma after inflammation has regressed is not yet available in the english literature. in this study, it is planned to evaluate the pediatric patients from this perspective and contribute to the literature with the results to be obtained.

Eligibility criteria:
inclusion criteria: * to be followed-up and treated in the department of pediatric surgery at trakya university due to epidididymo-orchitis. (inpatient and / or outpatient clinic) * 18 years old or younger * approval by the legal guardian exclusion criteria: * bilateral epididymo-orchitis * testicular pathology other than epididymo-orchitis (undescended testis, testicular torsion) * scrotal surgery (due to epididymoorchitis or not) * older than 18 years old

Keywords: epididymo-orchitis shear wave elastography
vitamin and unsaturated fatty acid supplements in healthy and uveitis human subjects

Conditions: Healthy; Uveitis; Autoimmune Diseases

Summary: the goal of this clinical trial is to learn if dietary supplements containing vitamin and unsaturated fatty acid works to intervene t cell inflammatory factor expression in patients with uveitis and healthy subjects in adults.


Eligibility criteria:
inclusion criteria: * healthy or with uveitis volunteers age 19-65 years. exclusion criteria: * abnormal blood glucose, blood pressure, blood lipids, or other systemic diseases should not participate in the study
aromatherapy versus diet

Conditions: Nocturnal Enuresis

Summary: eligible children were randomly divided into 2 groups assigned to receive dietary recommendations (group a) or to receive herbal compounds (group b). children were treated for a period of one week , then cross over the two groups is done


Eligibility criteria:
inclusion criteria: * the participants age will be ranged from 5to 10 years. * primary nocturnal enuresis(ne) number of wet nights/week is more than 4\\7 exclusion criteria: * secondary nocturnal enuresis to any neurological disorders , musculoskeletal problems, or congenital abnormalities * the child receives any pharmacological treatment to ne
benefit of topical hemostatic powder containing hydrophilic polymer with potassium ferrate for hemostasis following nail surgery

Conditions: Nail Diseases

Summary: the purpose of this study is to assess the efficacy and safety of topical hemostatic powder containing hydrophilic polymer with potassium ferrate for bleeding control after nail surgical procedures


Eligibility criteria:
inclusion criteria: * at least 18 years old * patients scheduled for any type of nail surgical procedure * willingness to participate in the study * ability to understand all instructions in the english language exclusion criteria: * failure to have nail surgery performed * likely inability to comply with the study protocol or cooperate fully with the research team

Keywords: nails nail surgery hemostasis potassium ferrate
core stability measures as a risk factor for the development of lower extremity injuries in physical education students

Conditions: Leg Injuries

Summary: male and female physical education students were subjected to a clinical test battery comprised of valid and reliable tests to measure different aspects of core stability at the start of the study. after a period of 2 months testing, the injury registration procedure started with the use of an online injury registration platform and regular call back moments. after 2 years of injury registration, all data was gathered and will be analysed statistically to link the measured core stability aspects as risk factors for certain lower extremity injuries.

september 2014 - december 2014: 139 male and female participants 18+ were subjected to different test to evaluate corresponding aspects of core stability. the following test were performed: star excursion balance test; lumbopelvic proprioception test; lumbopelvic neuromuscular control test; lateral step down test; hip strength test measured with a handheld dynamometer(flexion/extension/abduction/adduction/internal rotation/external rotation); trunk strength tests measured with a handheld dynamometer (trunk flexion and trunk extension) and core muscle endurance tests (prone bridging test/biering-sorenson test/side bridging tests). january 2015 - april 2017: prospective follow up of lower extremity injury contracted during sports activity. the injuries were confirmed by a medical examiner and were recorded in an online injury registry platform (survey monkey). statistical analysis will be performed to evaluate which core stability outcome measure can be considered a risk factor for the development of lower extremity injuries.

Eligibility criteria:
inclusion criteria: - 1st year of physical education study (enrolled at the artevelde graduate school or the ghent graduate school exclusion criteria: * musculoskeletal injury at the time of study participation * pre-existing lower back injury * pre-existing lower extremity injury (less than 6 months prior to study participation)

Keywords: abdominal muscles back muscles core stability field test muscle strength dynamometer lower extremity injury risk assessment prospective studies
a study to evaluate visually inspired patient education material on willingness to pursue radiation therapy

Conditions: Patient Education in Radiation Oncology

Summary: this research study is being done in order to better understand and identify american indian/alaskan native (ai/an) cancer patients' attitudes and beliefs towards radiation therapy treatment plans and their willingness to pursue them.


Eligibility criteria:
inclusion criteria: * patient at least 18 years of age with cancer diagnosis. * radiation therapy is recommended for their cancer treatment as a next step in their cancer care. * cognitive capacity to complete a paper-and-pencil survey. * ability to communicate and understand english with proficiency to provide informed consent and complete a paper-and-pencil survey. exclusion criteria: * patient \< 18 years of age. * patient does not have a cancer diagnosis.

Keywords: radiation therapy patient education radiation oncology native americans