Kornimate/medical-research-clean huggingface dataset:
absorbable suture versus tissue glue to repair defects following mohs surgery

Conditions: Basal Cell Carcinoma; Squamous Cell Carcinoma

Summary: the purpose of the study is to look at which nonpermanent superficial closure method, cyanoacrylate tissue glue or fast absorbing gut suture, leads to a better cosmetic and functional outcome in repairs of facial wounds after mohs surgery.

cyanoacrylate is a rapidly polymerizing topical adhesive commonly used as an alternative to traditional sutures. both cyanoacrylate and fast absorbing gut suture eliminate the need for suture removal which can represent a significant savings in patient and staff time as well as related healthcare resources. both cyanoacrylate and fast absorbing gut suture are currently routinely used for epidermal closure at yale following mohs micrographic surgery. physician preference currently dictates which epidermal closure method is chosen for a given surgery. cyanoacrylate has been reported to decrease trauma to the epidermal edges, minimize suture tract marks in surgical scars, and decrease the risk of inflammatory reaction to suture material. cyanoacrylate, however, does not allow for wound eversion. wound eversion minimizes the risk of a depressed scar from tissue contraction during healing. as with all sutures, fast absorbing gut suture allows for wound eversion which is reported to maximize the likelihood of a good epidermal approximation. on the other hand, fast absorbing gut suture degrades by proteolysis which can result in an inflammatory reaction. any inflammatory reaction on the skin while healing can affect the final cosmetic outcome (ie. post-inflammatory hyperpigmentation). a recent article (tierney 2009), reported that tissue adhesive may not be as effective in achieving optimal cosmesis as fast absorbing gut for defects on the trunk and extremities. however, we would like to study these two methods for the repair of facial wounds, which are in low tension areas as compared to trunk and extremities. therefore, it is unknown exactly which of these two method is better than the other in epidermal closure of facial wounds follow mohs micrographic surgery.

Eligibility criteria:
inclusion criteria: * the subject is willing and able to give informed consent. * the subject is willing and able to participate in the study as an outpatient and is willing to comply with study requirements. * the subject is 18 years of age or older. * the subject has a diagnosis of a non-melanoma skin cancer on the face requiring mohs micrographic surgery. * the subjects also has a final wound length of 3cm or greater. * the subject is able to abide by the protocol of standard postoperative care and is able to attend standard post-operative visits at 3 months after the surgery. exclusion criteria: * the subject is on systemic immunosuppressants and/or is an organ transplant recipients. * the subject has reported or suspected hypersensitivity to cyanoacrylate or fast absorbing gut suture. * the subject has a dermatologic disease in the target site that may interfere with examination.

Keywords: cyanoacrylate fast absorbing gut mohs surgery epidermal closure method
attitudes and barriers of prosthetics and orthotics professionals in turkey towards 3d printers and technology

Conditions: Technology

Summary: this study aim is the attitudes and barriers of prosthetics and orthotics professionals towards 3d printers and technology will be determined.

it is known that there are generally concerns about high capital costs and return on investment in the use of 3d printer technology in turkey. it is known that there is no study in turkey to investigate the attitudes and barriers of prosthetics and orthotics professionals towards 3d printers and technology. therefore, the attitudes and barriers of prosthetics and orthotics professionals towards 3d printers and technology will be questioned in the study. it was aimed to reveal the perspectives and concerns about 3d printers and technology and to emphasize the importance of increasing the number of education and competent personnel regarding the dissemination of technological applications in practice. in the study investigating the attitudes and barriers of prosthetics and orthosis professionals towards 3d printers and technology in turkey, a total of 131 participants, 29 female and 102 male, aged at least 18 and at most 65 years old, were included. the participants first filled out the demographic information form. this form includes demographic information such as the participant's age, gender, education level, profession, duration of professional experience, geographical region where they work, the number of in-service trainings they receive in the field of orthosis and prosthesis, weekly working hours and the number of daily patients they communicate with. at the end of the demographic information, the participants were asked to state open-endedly what they had concerns about technology that they could not define. in addition, questions created according to the technology acceptance model (tam) and the affinity for technology interaction (ati) were also answered by the participants. when the participants were asked whether they had concerns about 3d printers and technology that they could not define, it was determined that they mostly answered no. when the participants who had concerns were asked open-endedly about their concerns, the answers given were mostly about the lack of information or competent personnel for use when the answers were collected under common headings. it was observed that the technology acceptance model and proximity to technology had an effect on the time spent in the profession and the total score of ati.

Eligibility criteria:
inclusion criteria: * as working in an orthosis and prosthesis application center * being 18 years of age or older. exclusion criteria: * insufficient cognitive level to answer the survey

Keywords: three-dimensional printing anxiety orthosis limb prosthesis
cough reflex sensitivity and bronchial hyper-responsiveness

Conditions: Gastroesophageal Reflux Disease; Chronic Cough; Broncho-hyperreactivity

Summary: the aim of this study is to provide pilot data on the possible gastrointestinal predictors of respiratory hyper-responsiveness and how these relate to the clinical sub-types of gastroesophageal reflux disease (gerd) and visceral acid hypersensitivity.

this study recruited participants into three groups: reflux patients with non-erosive disease (nerd) with abnormal levels of acid reflux, nerd patients with normal levels of reflux and healthy volunteers. participants were assessed for cough reflex sensitivity (crs) to citric acid and bronchial-hyperresponsiveness (bhr) to methacholine challenge, both before (baseline) and after esophageal acid infusion (hcl, 0.15m) or normal saline control (8ml/min). the order of crs and bhr was randomized, as was the order of the acid/saline infusions.

Eligibility criteria:
inclusion criteria: * symptomatic reflux (i.e., one symptom at least one day a week, with at least 'moderate' severity) * no evidence of esophagitis * non-smokers exclusion criteria: * previous gastrointestinal surgery (excluding minor surgeries, such as cholecystectomy, appendectomy * active peptic ulcer disease * zollinger ellison syndrome * barrett's esophagus * eosinophilic esophagitis * cardiac disease * diabetes or neurological deficit * use of tricyclics * selective serotonin reuptake inhibitors * narcotics or benzodiazepines * current use of medications that may affect symptoms of perception,lower esophageal sphincter basal pressure, acid clearance time or acid suppression * antibiotics within 60 days * nursing mothers will be excluded * allergies to citrus * asthma * chronic lung disease * heart attack or stroke within the last three months * hypersensitivity to methacholine products * know aortic aneurysm * uncontrolled hypertension (defined as systolic pressure greater than 200 or diastolic greater than 100) * reduced pulmonary function test (forced expiratory volume in one second (fev1) or the fev1 to forced vital capacity (fvc) ratio (fev1/fvc) of less that 70% of predicted value) * none of the controls will have any gerd symptoms or ever used antireflux treatment.
mri study of antidepressants in the treatment of refractory functional dyspepsia

Conditions: Therapeutic Mechanism of Antidepressants for Refractory FD

Summary: in this study, diffusion tensor imaging（dti）technique was used to evaluate the brain microstructures and connective white matter microstructures in patients with refractory fd, resting fmri was used to evaluate the functional connectivity between hemispheres, and neuroimaging changes after antidepressant intervention were observed to explore the activation patterns of resting brain homeostasis-receptive network areas in patients with refractory fd. we aimed to explore microstructure of white matter and gray matter and functional connectivity between hemispheres to explain the therapeutic mechanism of antidepressants.

in this study, functional magnetic resonance imaging (fmri) was used to investigate the abnormal activation patterns of brain regions in patients with refractory fd in resting state, and to observe the changes of brain functions after antidepressant treatment, in order to find scientific evidence for exploring the etiology, neuropathological mechanism and the mechanism of antidepressant treatment of refractory fd.

Eligibility criteria:
inclusion criteria: * age 18-60 years old, meeting the criteria for inclusion of refractory fd * hp infection negative * right handedness exclusion criteria: * antidepressant drug allergists * history of gastroduodenal surgery; * researchers judged suicidal ideation. * women in pregnancy or lactation. * patients with uncorrected narrow angle glaucoma. * there was a history of epileptic seizures. * suffering from any serious or unstable medical disease or disease. * addiction to illicit drugs or alcohol and unwillingness to discontinue use during the study period. * patients can't express their complaints correctly and can't cooperate with the researcher.

Keywords: antidepressants refractory functional dyspepsia resting fmri
mpmri compared to diagnostic turbt in patients with suspected muscle-invasive bladder cancer

Conditions: Urothelial Bladder Cancer; Muscle-Invasive Bladder Cancer

Summary: this is a pilot, single arm, prospective study that aims to validate the accuracy of the vi-rads score obtained via multi-parametric magnetic resonance imaging (mpmri) compared to pathologic cancer stage obtained via diagnostic transurethral bladder tumor resection (turbt) as well as compare the clinical and quality of life outcomes between these diagnostic modalities in patients with suspected muscle-invasive bladder cancer (mibc).


Eligibility criteria:
inclusion criteria: * age 18 years old or greater at the time of consent. * suspected muscle-invasive bladder cancer by tumor appearance on initial routine cystoscopy as determined by the uci-affiliated urologist performing this procedure. * ecog performance status of 0-3. * patients must have the ability to understand and the willingness to sign a written informed consent document (prior to the initiation of the study and any study procedures). * patients must be willing and able to comply with the scheduled visits, imaging plan, follow up plan, and other specified study procedures in the opinion of the investigator. exclusion criteria: * prior turbt within 120 days of study entry. * prior therapy for bladder cancer within 120 days of study entry. * inability to tolerate mpmri or associated contrast. * inability to tolerate turbt or associated anesthesia. * ecog performance status of 4. * female patient who is known to be pregnant or breastfeeding.

Keywords: mpmri turbt vi-rads score
smart-ibd app trial

Conditions: Inflammatory Bowel Diseases; IBD; Crohn Disease; Ulcerative Colitis

Summary: the objective of this trial is to test whether a smartphone app, smart-ibd, is effective in improving medication adherence and self-management skills in adolescents with ibd. the investigators will conduct a randomized control trial to compare a sample of 15 youth (ages 13-17) with ibd using an app that has educational content and medication reminders to 15 youth in an attention control group. the length of the intervention will include one month of baseline adherence data collection, one month of intervention, and one month of post-treatment adherence data collection.


Eligibility criteria:
inclusion criteria: * patient diagnosed with crohn's disease, ulcerative colitis, or indeterminate colitis (collectively ibd) * prescribed at least one medication used to treat ibd, regardless of route of administration * access to internet or wi-fi or data plan and access to smartphone * english fluency for patient and clinician exclusion criteria: * diagnosis of pervasive developmental disorder in patient or caregiver as determined by medical chart review * diagnosis of serious mental illness (e.g., schizophrenia) in patient or caregiver as determined by medical chart review

Keywords: ibd
enteral nutrition and glucose homeostasis

Conditions: Hyperglycemia Stress

Summary: different enteral nutrition formulas are tested on their effect on glucose homeostasis in critically ill medical patients.

to assess whether enteral nutrition fomulas based either on fat or glucose influence glucose homeostasis differently in critically ill medical patients. all patients are admitted to a tertiary icu and require mechanical ventilation. resting energy expenditure is assessed at baseline in the fasting state by indirect calorimetry. total energy demand is calculated and patients are randomized to receive fat-based or glucose-based nutrition which is administered continously for 7 days. indirect calorimetry is repeated on days 3 and 7 under continous nutrition. during the study period, various parameters of glucose homeostasis are assessed. daily, there will be at least 3 measurements of blood glucose, more if the treating physician deems it necessary. daily average glucose, daily glucose variability, overall area under the curve for glucose are calculated. furthermore, energy intake by nutrition, medications (i.e. propofol), and glucose infusion, as well as substrate intake, and insulin demand per 24hrs are determined daily. adverse effects such as episodes of hyper- or hypoglycemia, cholestasis, hypertriglyceridemia, diarrhea, vomiting, and the amount of gastric residual volume are noted.

Eligibility criteria:
inclusion criteria: * medical patient with need for mechanical ventilation * fio2 requirement \< 60% * need for nutritional support exclusion criteria: * contraindications against nutritional therapy * hemodynamic shock (lactate of ≥ 4 mmol/l) * severe hypertriglyceridemia (≥ 450 mg/dl) * contraindications against enteral nutrion (intestinal obstruction, disruption or severe bleeding of upper gastrointestinal tract)

Keywords: criticall illness enteral nutrition
project impact immunizations (improving america's communities together) scaled demonstration

Conditions: Influenza

Summary: the primary objective of this study is to evaluate how implementing an innovative care model that provides the pharmacist access to a patient's vaccine history at the point-of-care impacts the pharmacist's ability to identify unmet vaccination needs and increase vaccination rates for routinely recommended adult vaccinations.

this multi-site study will use a pre-post design with a population-based comparison group to investigate the impact of implementing an innovative care model on the pharmacist's ability to identify unmet vaccination needs and increase vaccination rates for routinely recommended adult vaccinations. the innovative care model enables the pharmacist to utilize a bi-directional iis to assess patients' vaccination histories, identify unmet vaccination needs, and document the care provided. the project duration has been established to allow sufficient time for each pharmacy to implement the innovative care model and monitor each pharmacy for a 6-month study period. the american pharmacists association (apha) foundation has an a priori intent to publish the project results.

Eligibility criteria:
inclusion criteria: * individuals eligible to be enrolled in the study include any person at least 18 years of age who is eligible for a comprehensive vaccination history review as determined by the pharmacist. exclusion criteria: * n/a

Keywords: preventable disease vaccine public health vaccine history point-of-care
prospective assessment project about cardiac arrest resuscitation

Conditions: Cardiac Arrest

Summary: in case of a cardiac arrest it is very important to quickly provide high quality cardiopulmonary resuscitation (cpr). for reasons of patient safety the investigators want to assess the frequency, the quality and the outcome of cardiopulmonary resuscitations in the inselspital bern.


Eligibility criteria:
inclusion criteria: * every patient for which the alarm button for a cardiopulmonary arrest gets triggered exclusion criteria: * none
percepic: perc rule combined with implicit low clinical probability

Conditions: Pulmonary Embolism; Dyspnea; Thoracic Pain

Summary: perc rule was created to rule out pulmonary embolism (pe) without further exams, with residual pe risk \<2%. its safety is currently confirmed in low pe prevalence populations as north-american. in european high pe prevalence population, it has been showed that perc rule used alone or associated with low clinical probability assessed by revised geneva score (rgs) was not safe. in retrospective study, we suggest that the combination of perc rule with implicit clinical probability (gestalt) could allow the use of the perc rule. percepic, an observational prospective multicenter study performed in france and belgium, will test this hypothesis. therefore, 3000 patients will be included in 12 centers. primary outcome will be the rate of thromboembolic events or death related or possibly related to pe in patients with low implicit clinical probability and negative perc rule (8 criteria absents). upper limit of confidence interval of this rate must be equal or lower than 3% to consider perc rule as safe in this combination.


Eligibility criteria:
inclusion criteria: - patients admitted to the emergency department for one of the following criteria : * dyspnea and/or thoracic pain without another obvious cause * pulmonary embolism suspicion whatever the reason exclusion criteria: * age lower than 18 * patients hospitalized for more than 48h * ongoing curative anticoagulant therapy for more than 48h before admission * patients with thromboembolic disease diagnosed before the admission * unavailability for follow-up (short life expectancy, no phone number...) * patient refusing to be contacted by phone at 3 month * patient refusing that medical data were collected * secondary exclusion criteria : curative anticoagulant therapy for more than 5 days during the 3 month follow-up for another reason than thromboembolic disease.

Keywords: pulmonary embolism diagnostic strategy exclusion clinical probability implicit judgment (gestalt) perc
trial of hypofractionated intensity modulated radiation therapy with temozolomide and granulocyte-macrophage colony-stimulating factor for patients with newly diagnosed glioblastoma multiforme

Conditions: Glioblastoma Multiforme

Summary: phase ii trial of hypofractionated intensity modulated radiation therapy(imrt) with temozolomide and granulocyte-macrophage colony-stimulating factor(gm-csf) for patients with newly diagnosed glioblastoma multiforme.


Eligibility criteria:
inclusion criteria: * newly diagnosed and pathologically confirmed glioblastoma multiforme without an enhanced lesion beside the cerebrospinal fluid space on baseline magnetic resonance imaging * karnofsky performance status more than 60 * normal liver, kidney, and bone marrow function. exclusion criteria: * previous allergies to granulocyte macrophage colony stimulating factor * receiving radiotherapy * receiving other investigational agents * had uncontrolled intercurrent illnesses.
effects of electroacupuncture on cognitive symptoms in major depressive disorder

Conditions: Major Depressive Disorders; Cognitive Dysfunction

Summary: the goal of this pilot study and randomized controlled trial is to investigate the impact of electroacupuncture on cognitive function, quality of life (qol), and depression severity in patients with major depressive disorder (mdd). the main question\[s\] it aims to answer are: * primary : electroacupuncture has the potential to treat subjective cognitive complaints and cognitive impairment in mdd outpatients * secondary : electroacupuncture has the potential to treat depressive in mdd outpatients the 60 participants will randomly be assigned to either the treatment group or the control group in a 1:1 ratio. the treatment group will undergo electroacupuncture (ea), while the control group will receive sham acupuncture within 10 weeks period. both groups will receive antidepressants with adjunctive medication (i.e., benzodiazepines, tricyclics, or antipsychotics) as the standard treatment. all participants will be assessed for executive functions and memory using specific cognitive tests, including the trail making test b (tmt-b), stroop color and word test (scwt), category delayed recall in the alzheimer's disease assessment scale-cognitive subscale (adas-cog), and subjective reports of concern regarding concentration, memory, problem-solving, learning, communication, and quality of life (qol) concerns using the who disability assessment schedule (whodas 2.0; sections d1.1-1.6 and h1-3), and depressive symptoms were assessed using the thai-phq-9.


Eligibility criteria:
inclusion criteria: * aged between 18 and 55 years * mdd diagnosed according to the dsm-5 or dsm-iv-tr criteria, * low suicidal risk * receiving treatment with antidepressants for at least 3 months from psychiatrists and psychiatric residents. * subjective cognitive symptoms from the screening using the thai version of the patient health questionnaire (thai-phq-9). exclusion criteria: * severe cognitive deficits from traumatic brain injury, delirium, neurodevelopmental disorders, or intellectual disability; * neurological disorders such as stroke, parkinson's disease, epilepsy, or other brain lesions; * severe medical conditions preventing lying down for 20 minutes; * recent electroconvulsive therapy (ect) within the last 6 months; * individuals with a pacemaker; * visual or hearing impairment that could not be corrected with eyeglasses or hearing aids; * severe mdd or scoring 20 points or more on the thai-phq-9.

Keywords: electroacupuncture depression cognition humans pilot randomized controlled trial
pk and pd study of calcitriol 3 mcg/g ointment in pediatric subjects with plaque psoriasis

Conditions: Plaque Psoriasis

Summary: the purpose of this study is to determine if the calcitriol absorption in pediatric subjects is comparable to that in adults and adolescents, with no significant impact on calcium/phosphorus metabolism.


Eligibility criteria:
inclusion criteria: * male or female pediatric subjects, 2 to 12 years of age inclusive at screening * clinical diagnosis of plaque type psoriasis involving 3% through 35% body surface area at screening and baseline (excluding face and scalp) exclusion criteria: * subjects with guttate or pustular psoriasis, erythrodermic psoriasis or active infection * vitamin d deficiency at screening * subjects with hypercalcemia and out of range urinary calcium/creatinine ratio at screening * subjects with secondary hyperparathyroidism at screening