Kornimate/medical-research-clean huggingface dataset:
guided imagery and music for the reduction of side effects of chemotherapy in teenagers

Conditions: Cancer

Summary: the purpose of this study is to determine whether a modified and resource-oriented form of guided imagery and music (gim) is effective in reducing side effects of chemotherapy in teenagers with cancer.

(will be added later)

Eligibility criteria:
inclusion criteria: 1. teenagers at the ages 12-17 2. four or five (dependent on their overall plan of medical treatment) consecutive courses of chemotherapy administrated at the involved child cancer units and (administered) over a period of minimum 24 hours incl. hydration with assumed moderate to severe nausea and vomiting. the specific type of chemotherapy may vary across the four/five consecutive courses but shall include one of the following moderate and/or highly emetogenic types of chemotherapy: moderate emetogenic chemotherapy: * carboplatin * cyclophosphamide \<1500 mg/m2 * cytarabine \>1 g/m2 * daunorubicin * doxorubicin * epirubicin * idarubicin * ifosfamide * mitoxantrone * methotrexate \>1000 mg/m2 highly emetogenic chemotherapy: * cisplatin \>25 mg/m2 * cyclophosphamide \>1500 mg/m2 * dacarbazine 3. understand norwegian/danish 4. read norwegian/danish (teenagers or alternatively parents) 5. no significant hearing impairment 6. informed written consent (teenagers ≥16 years and parents) 7. subsequent verbal confirmation of written informed consent before enrolment in study exclusion criteria: 1. previous and/or acute psychiatric diagnosis 2. cognitive and mental deficits or impaired functioning

Keywords: teenager moderate and/or highly emetogenic chemotherapy
comparison of intravitreal ranibizumab and macular laser photocoagulation for me following branch retinal vein occlusion (brvo)

Conditions: Branch Retinal Vein Occlusion

Summary: this study is designed to evaluate the efficacy of intravitreal ranibizumab in comparison with macular laser photocoagulation as treatments for macular edema secondary to branch retinal vein occlusion. characteristics of this study is as below 1. multicenter, randomized clinical trial. (intravitreal ranibizumab 0.5mg injection vs. macular laser photocoagulation) 2. after 48 weeks follow up, functional change(visual acuity)and anatomical change (central retinal thickness) would be evaluated


Eligibility criteria:
inclusion criteria: * symptom duration \ 4 weeks * visual acuity - less than 20/40 (73 letters) more than 20/400 (19 letters) in etdrs chart * oct - center involved retinal thickening : \> 250 micrometers * clear media * well controlled hypertension (\<140/90mmhg) and diabetes (6.5\<hba1c\<9.5) * willing to return for all scheduled visits exclusion criteria: * uveitis,nvg, exudative amd, diabetic retinopathy, irvine-gass syndrome, ois * any malignancy * previous treatment history - laser photocoagulation, intravitreal injection with any drug, vitrectomy * vitreomacular traction or epiretinal membrane * intraocular surgery in the study eye within 6 months * uncontrolled glaucoma ( \> 30mmhg with anti-glaucoma medications) * optic neuropathy, amblyopia * a condition that in the opinion of the investigator would preclude a patient's participation in the study

Keywords: branch retinal vein occlusion macular edema intravitreal injection ranibizumab
the first-line treatment of rclm with ras mutation was local short-course radiotherapy (scrt) + pd-1+ standard therapy

Conditions: Rectal Cancer

Summary: to explore the efficacy and safety of radiotherapy followed by pd-1+ standard chemotherapy in the first-line treatment of initial unresectable rectal cancer liver metastases


Eligibility criteria:
inclusion criteria: * histologically confirmed adenocarcinoma of the rectum； * the clinical stage evaluated by mri was t3-4 and/or n+ and m1a(only liver metastasis)； * ecog ps 0-2； * child pugh a； * estimated survival ≥3 months; * women of childbearing age should comply with contraceptive measures if pregnancy test is negative; * adequate organ and bone marrow functions, ecg, blood, biochemical and other basic tests are not contraindications of chemotherapy; * adherence to scheduled visits, treatment plans, laboratory tests, and other study procedures willingness and ability. exclusion criteria: * pregnant or lactating women; * no previous antitumor therapy； * no previous liver local therapy； * no contraception during the reproductive period; * patients known to have a history of allergy to any study drug, similar drug or excipient; * patients with risk of massive gastrointestinal bleeding or gastrointestinal obstruction; * patients with a history of thromboembolism, except those caused by picc; * patients with active infection; * other conditions that the investigator determines are not suitable for inclusion in the study.
bioefficiency of of conventional fish and vitamin d fortified fish

Conditions: Vitamin D Deficiency

Summary: the aim of this study is to investigate the bioavailability of conventional and vitamin d fortified fish as measured by the increase of the specific hydroxy form by 25(oh)d3.

study design: human volunteers will receive conventional fish or vitamin d fortified fish for a period of 4 weeks. at baseline and after 4 weeks, 25(oh)d3 will be measured in serum as the main outcome variables. additional outcome variables are the ca concentration in serum, pth concentration in serum. groups/cohorts assigned interventions 1. placebo group receiving conventional fish 2. intervention group receiving vitamin d fortified fish

Eligibility criteria:
inclusion criteria: * 18 years * healthy exclusion criteria: * supplementation of vitamin d and calcium * hypercalcemia * hypercalciuria * chronical illness (diabetes, kidney diseases, cardiovascular diseases) * serum-creatinine above 115 mmol/l * pregnancy or breastfeeding women

Keywords: vitamin d bioeffiency vitamin d fortified fish
inferior vena cava collapsibility index guide for preoperative fluid therapy in preeclampsia

Conditions: Pre-Eclampsia; Hypotension; Fluid Overload

Summary: the routine assessment of fluid status depends on clinical evaluation and invasive monitoring. the clinical assessment lacks objectivity and the invasive monitoring carries risks. point of care ultrasound (pocus) parameters can be useful as early markers of fluid status and were used in safe fluid assessment in term pregnancy and preeclampsia.

fluid therapy in preeclamptic patients presents a challenge. volume expansion may precipitate pulmonary edema while fluid restriction may worsen renal function and may aggravate post-spinal hypotension during cesarean section. pre-eclampsia predisposes to maternal mortality. it presents a serious hypertensive disorder during pregnancy which may progress rapidly to serious complications, including the death of both mother and fetus the optimal fluid management strategy constitutes a cornerstone in the management. the royal college of obstetricians and gynecologists (rcog) guidelines for severe pre-eclampsia recommend restrictive fluid therapy, in keeping with the absence of evidence favoring volume expansion. restrictive management is advocated by the society of obstetric medicine of australia and new zealand (somanz) with additional fluid administration only recommended before intravenous hydralazine, regional anesthesia, immediate delivery, or in oliguric patients where a volume deficit is suspected. overall, limited evidence exists regarding the effectiveness of ultrasound assessment of the ivc collapsibility index to guide pre-operative fluid management in critically ill pre-eclamptic patients. a meta-analysis stated that few research trials are available in the obstetric population. some studies suggest that it can accurately predict fluid responsiveness, but others argue that it may not be helpful. our trial is the first trial that compares the efficacy of ivcci-guided perioperative fluid therapy against standard fluid therapy guided by clinical parameters in critically ill pre-eclamptic patients.

Eligibility criteria:
inclusion criteria: * critically ill pre-eclamptic patients for cesarean section exclusion criteria: * patient refusal * severe cardiovascular disease ( ejection fraction \< 40 mmhg ), tricuspid regurge. * contraindication for spinal anesthesia. * failure to perform spinal anesthesia. * severe hepatic. * renal dysfunction
individually tailored lighting system to improve sleep in older adults

Conditions: Sleep Disturbances

Summary: in conjunction with investigators at the cecil g. sheps center for health services research, university of north carolina (unc) at chapel hill, we propose to develop and evaluate a low-cost, minimally obtrusive device that delivers individualized light therapy to adults with early-awakening insomnia - the most common sleep disturbance in older adults, and a significant problem because of its relationship to daytime sleepiness, use of potentially hazardous sleep medication, and reduced quality of life. the proposed device will measure light/dark exposure data over 24 hours, estimate optimum timing for light delivery, and deliver an individualized light dosage while subjects are asleep. light applied through closed eyelids in the early part of the night will delay the dim light melatonin onset, a marker of the circadian clock, and help those with early sleep onset to fall asleep later

we will recruit 50 subjects who report going to bed early and desiring later bedtimes and will ask them to wear an active and an inactive light mask for 8 consecutive weeks each. a 2-week washout period between active and inactive conditions will be applied. outcome measures will be collected periodically throughout the 8 weeks. baseline (no intervention) will be collected prior to the active and inactive lighting interventions.

Eligibility criteria:
inclusion criteria: * age 65 or older * cognitively capable * able to respond to study staff verbally and in english * score greater than 6 using the pittsburgh sleepiness quality index * suffer from insomnia * suffer from excessive daytime sleepiness exclusion criteria: * severe sleep apnea * severe restless leg syndrome (rls) * significant cognitive impairment * history of severe photosensitivity dermatitis

Keywords: light circadian rhythms dim light melatonin onset sleep
the effect of a multispecies probiotic on hypersensitivity in irritable bowel syndrome (ibs) patients

Conditions: Irritable Bowel Syndrome; Hypersensitivity

Summary: the purpose of this study is to determine whether a specifically designed multispecies probiotic decreases visceral hypersensitivity in ibs-patient (defined by an increased pain tolerance threshold). moreover, the effect on general symptom scores and inflammatory and microbiological parameters will be studied.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of ibs according to the rome iii criteria * increased visceral perception according to barostat measurements, defined as a pain tolerance threshold at smaller than or equal to 23 mmhg * age between 18 and 65 years * bmi between 18.5 and 30 kg/m2 exclusion criteria: * known gastro-intestinal diseases * major abdominal surgery * previous radiotherapy, chemotherapy * clinical significant systemic diseases * critically ill patients or patients suffering from severe acute pancreatitis * patients with organs failure * patients receiving enteral feeding * excessive alcohol intake (greater than 15 consumptions per week) * (planned) pregnancy or lactation * use of pre-, probiotics in the month before and during the study * use of antibiotics in the two months before and during the study * use of anti-diarrhoea medication, anti-laxatives or anti-acid medication in the two weeks before and during the study * use of anti depressives (especially ssri's) in the month before and during the study * use of other medication if less then one month on stable dosage

Keywords: irritable bowel syndrome hypersensitivity probiotics multispecies
the effect of cold storage solutions on ischemic injury in lung transplantation

Conditions: Lung Transplant Recipients

Summary: the purpose of this study is to compare 2 different cold storage solutions, used to preserve donor lungs for lung transplantation, and their effect on cytokine activation related to ischemic reperfusion injury. primary endpoint is 30 day survival.

the length of ischemic time in harvesting lung allografts is associated with graft survival. it is further thought that ischemic changes in early post-transplantation bronchoscopic biopsies has a direct correlation with later development of chronic rejection.

Eligibility criteria:
inclusion criteria: any patient undergoing a lung trasnplant at johns hopkins hospital - exclusion criteria: -

Keywords: cytokines in lung transplantation cold storage solutions ischemic reperfusion injury
clinical and urodynamic evaluation of surgical repair of pelvic organ prolapse associated with lower urinary tract symptoms

Conditions: Pelvic Organ Prolapse

Summary: to assess the urinary symptoms and urodynamic findings concomitant with pelvic organ prolapse before and after surgical treatment and to define the role of urodynamic study in treatment decision making.

pelvic organ prolapse (pop) is a prevalent problem that affects women's quality of life women with pop may present with a variety of lower urinary tract symptoms (luts). for pop patients with concomitant urinary symptoms, urodynamic (udn) testing is proposed for proper evaluation of cases and identification of the pathophysiologic events in each case individually. in this prospective study, the investigators aim to describe the urinary symptoms and urodynamic findings concomitant with pop before and after surgical treatment of pop. we also aimed at defining the role of udn in decision-making regarding the treatment of pop when associated with luts.

Eligibility criteria:
inclusion criteria: * women with anterior pelvic organ prolapse (pop) associated with lower urinary tract symptoms exclusion criteria: * patients with pop less than pop-q grade ii, pop not in need for surgical repair, neurological diseases that could possibly affect voiding functions, pelvic infections, congenital bladder disorders, history of urinary fistula, history of malignancy, and patients on current medical treatment for voiding dysfunction.
ultra-low dose computed tomography for diagnosis and follow-up of patients with diffuse parenchymal lung disease (dpld)

Conditions: Diffuse Parenchymal Lung Disease

Summary: the primary intention of this study is to determine the diagnostic performance of ultra-low-dose ct (uldct) in diagnosis and follow-up of diffuse parenchymal lung disease (dpld). we hypothesize that inspiratory and expiratory chest uldct has comparable diagnostic yield to standard dose chest high-resolution computed tomography (hrct) and utility for follow-up of patients with known dpld. we will study this hypothesis through the following aims: 1. determine whether inspiratory and expiratory uldct are comparable to hrct in identifying mosaic attenuation due to air-trapping. 2. determine whether uldct is as good as hrct for follow-up of patients with established dpld to identify disease progression.


Eligibility criteria:
inclusion criteria: 1. suspected or known dpld 2. referred to dpld observation exclusion criteria: 1. other lung related diseases -
risk factors for anal sphincter damage during vaginal delivery

Conditions: Anal Sphincter Injury; Fecal Incontinence

Summary: vaginal delivery may cause various levels of damage to the anal sphincter. according to the literature, one third - two third of women diagnosed with 3rd degree rupture during vaginal delivery suffer from fecal incontinence. this has an adverse effect on the quality of life. different risk factors such as: first births, instrumental delivery, high birth weight, prolonged second stage, epidural anesthesia etc. were assessed and found to be associated with anal sphincter disruption. the purpose of this study is to assess risk factors for anal sphincter disruption by new methods such as three-dimensional transperineal ultrasound (3d transperineal us).


Eligibility criteria:
inclusion criteria: * first delivery * vaginal delivery * birthweight \> 3000 * singleton pregnancy exclusion criteria: * anal sphincter disruption before birth

Keywords: anal sphincter injury fecal incontinence
therapeutic strategy in advanced bronchioloalveolar carcinoma

Conditions: Adenocarcinoma, Bronchiolo-Alveolar

Summary: to evaluate among patients with untreated advanced adc-cba, impact on the disease control rate after 4 months treatment of an early therapeutic permutation with the first month in the absence of stabilization or objective answer.


Eligibility criteria:
inclusion criteria: * cba histologically proven (or cytologically with pneumonic presentation) ps \< 3 signed and written informed consent exclusion criteria: * visible tumoral lesion in bronchial fibroscopy

Keywords: adenocarcinoma, bronchiolo-alveolar
quantitative stress echocardiography to diagnose myocardial ischaemia

Conditions: Ischemia, Myocardial

Summary: patients with chest pain on exertion need a reliable non-invasive test to identify if they have inducible myocardial ischaemia. this would reduce the use of diagnostic coronary arteriography, avoid its risks and costs, and guide clinical decisions. conventional stress echocardiography has poor reproducibility because it relies on qualitative and subjective interpretation. quantitative approaches based on precise and reliable measurements of myocardial velocity, strain, strain rate and global longitudinal strain have been shown to be able to accurately diagnose myocardial ischaemia. a more accurate test using myocardial velocity imaging was not implemented by ultrasound vendors although it provided an objective measurement of myocardial functional reserve on a continuous scale from normality to severe ischaemia. the investigators propose an original approach to create a diagnostic software tool that can be used in routine clinical practice. the investigators will extract and compare quantitative data obtained through myocardial velocity imaging and speckle tracking in subjects who undergo dobutamine stress echocardiography. the data will be analysed using advanced computational mathematics including multiple kernel learning and joint statistics applied to multivariate data across multiple dimensions (including velocity, strain and strain rate traces). this approach will be validated against quantitative coronary arteriography and fractional flow reserve. the results will be displayed as parametric images and placed into a reporting tool. the output will determine the presence and severity of myocardial ischaemia. these new tools will have the capacity for iterative learning so that the precision of the diagnostic conclusions can be continuously refined.


Eligibility criteria:
inclusion criteria: * chest pain, chest pain equivalent exclusion criteria: * acute coronary syndrome with elevated troponin, severe heart valve disease, uncontrolled hypertension (resting sbp \>200mmhg), cardiomyopathy, contraindication to dobutamine, pregnancy

Keywords: myocardial velocity imaging strain strain rate speckle tracking deformation quantitative echocardiography machine learning
individual and family motivational interviews for substance using truant teens

Conditions: Substance Use

Summary: this application will provide a test of one potential model for adding substance use assessment and brief intervention into a truancy court program. the primary goal of this study is to determine whether a motivational intervention will reduce substance use among adolescents referred to truancy court for school attendance problems. in this treatment development application, an open trial with 20 families referred by truancy court will first be conducted. this trial will be used to adapt an existing motivational intervention to include material relevant to school attendance and performance. then 100 families participating in the rhode island truancy court program with adolescents between the ages of 13-16 years who report using substances will be randomly assigned to receive the experimental intervention plus standard truancy court procedures or psychoeducation plus standard truancy court procedures. the 2-session intervention protocol consists of an individual motivational interview plus the family check-up (dishion \& kavanagh, 2003), a family based motivational interview. the experimental protocol provides a thorough assessment of both individual and family strengths and weaknesses with respect to substance use prevention and school attendance/performance. follow-up interviews will be conducted at 3 and 6 months.


Eligibility criteria:
inclusion criteria: 1. between the ages of 13-16 at the start of the project and living at home with at least one parent/guardian, 2. t- score of 70 or above on one of the diagnostic-oriented scales (internalizing or externalizing problems) on the child behavior checklist (i.e. reach the clinical cut-off), 3. the child must report 6 or more incidences of substance use in the last 90 days, 4. parental consent and child assent are obtained. exclusion criteria: 1. adolescent meets diagnostic criteria for substance dependence suggesting need for more intensive services, 2. the family is not able to speak and understand english or spanish well enough to complete study procedures.

Keywords: substance use adolescents intervention truancy
clinical evaluation of a test for monitoring patients diagnosed with chronic myeloid leukemia (cml)

Conditions: Leukemia, Myelogenous, Chronic

Summary: the objective of this study is to establish the performance of an assay that detects mrna transcript levels in patients diagnosed with cml. the study is conducted at locations within the united states. testing is performed on peripheral blood specimens provided by eligible enrolled patients. results from this study will not be used for patient management decisions.


Eligibility criteria:
inclusion criteria: * prospective specimens: * patient is at least 18 years of age * patient has provided documented informed consent as required by the reviewing irb. experimental bill of rights will also be documented for all subjects enrolled in applicable states. * patient has been diagnosed with cml. * patient consents to provide at least 12 ml of peripheral blood for study purposes * frozen specimens: * specimen is from a subject diagnosed with cml * specimen meets the manufacturer's criteria to support testing by both diagnostic assays exclusion criteria: * prospective specimens: * patient is considered to be of insufficient health to supply the required volume of peripheral blood by his/her health care provider * patient has been previously enrolled * frozen specimens: • specimen previously enrolled
rhythmic sensory stimulation on fibromyalgia

Conditions: Chronic Pain, Widespread

Summary: the aim of this project is to further examine the effectiveness of rhythmic sensory stimulation (rss) with low-frequency sounds and somatosensory stimulation as a complementary therapy for fibromyalgia, and to investigate potential mechanisms underlying the effects of rss on chronic pain.


Eligibility criteria:
inclusion criteria: * patients with clinical diagnosis of fibromyalgia * able to read and write english adequately * have satisfactory hearing bilaterally (self-reported) * have the ability to operate the supplied device exclusion criteria: * acute and active inflammatory conditions (e.g., rheumatoid arthritis, osteoarthritis, autoimmune disease) * medical or psychiatric illness * history of psychosis, epilepsy, seizures * pregnancy or breast feeding * hemorrhaging or active bleeding * thrombosis, angina pectoris * heart disease, such as hypotension, arrhythmia, pacemaker * substance abuse (harmful or hazardous use of psychoactive subtances, including alcohol and illicit drugs) in the last year * suffering from a recently prolapsed vertebral disc * recovering from a recent accident with back or neck injury.