Kornimate/medical-research-clean huggingface dataset:
microbiome influence on seminal quality

Conditions: Infertility, Male

Summary: the microbiome plays an important role in health and in some unknown etiologies. some previous studies have identified bacteria in semen as a potential factor in male infertility. more studies are needed to discover associations between microbiomes and semen quality. in this study, forty semen samples from donors candidates will be collected where clinical criteria for seminal quality (volume, concentration, motility and morphology) will be measured and bacterial communities examined. with the next-generation sequencing of gene technology and bioinformatic analysis, we can investigate the associations between bacterial communities and seminal quality. it would be interesting to know if the proportion of certain bacteria is significantly higher in samples of normal seminal quality or significantly higher in samples of low seminal quality. this study could contribute to the current understanding of certain etiologies of male fertility.

surplus semen samples will be collected from donor candidates who come to the ivi alicante clinic with ages between 18 and 35 years old and who intend to participate in the donation program for the semen bank, and come to evaluate their quality. informed consent for this study will be given to all of them, which they will have to return signed. depending on the semen quality evaluated in the diagnostic sample within the usual practice, in the laboratory the participants will be divided into 2 groups according to the who reference values in terms of sperm concentration and percentage of progressive motility: * group a (normozoospermics): ≥15 mill / ml and\> 32% progressive mobility. * group b (non-normozoospermic): \<15 mill / ml and \<32% progressive mobility. the study will consist of 2 years. the first year will be used to collect all the diagnostic seminal samples from donor candidates, and the second year will be used in its first months to analyze the microbiome by extracting dna from ejaculates, amplifying bacterial dna with targeted primers. to the bacterial 16s rrna gene regions, sequencing, library preparation and bioinformatic analysis.

Eligibility criteria:
inclusion criteria: * 18-35 years. suitable on your first informational visit. exclusion criteria: * presence of own or hereditary pathology. presence of mental or behavioral disturbance

Keywords: microbiome semen
intraoperative eabr for decision making

Conditions: Vestibular Schwannoma; Hearing Loss

Summary: in this study patients undergoing simultaneous translabyrinthine vestibular schwannoma resection and cochlear implantation are included. the goal of the study is to correlate the eabr results with postoperative hearing results.

patients undergoing translabyrinthine vestibular schwannoma resection are included in the study. preoperatively an eabr is carried out, as well as before and after tumor resection. postoperatively patients are fitted with a cochlear implant as routinely carried out. the postoperative hearing results with cochlear implant are correlated to the eabr results. the study is an observational study since eabr measurements are not part of the study. a correlation between eabr results categorized in three groups (good response, weak response, no response) with monosyllable understanding with cochlear implant (measured with freiburger monosyllables test).

Eligibility criteria:
inclusion criteria: * patients between 18 and 99 years undergoing translabyrinthine vestibular schwannoma resection * patients wanted hearing rehabilitation with a cochlear implant exclusion criteria: * patients who do not want to be part of the study

Keywords: cochlear implant
follow up by us following hospitalization with periappendicular abscess refusing to be operated on within a few weeks.

Conditions: Disorder of Appendix

Summary: follow up via ultrasonic abdoman after patients who were giagnosed and treated as periappendicular abcess and refused to be operated later on in the "interval period ". to ass what occured to their appendics ?

during the last 10 years patients were hospitalized and treated with antibiotics due to the diagnosis of periappendicular abcess. they were invited to be operate after wards -appendectomy, electively few weeks later on. all these patients refused to be operated. what happend to their appendics few months or years later on via ultrasonic abdomen view??

Eligibility criteria:
inclusion criteria: * all patients diagnosed in the last 10 years suffering from periappendicular abcess. exclusion criteria: * after appendectomy

Keywords: periappendicular abscess ultrasound
clinical trial evaluating chlorine e6 derivative-mediated antimicrobial photodynamic therapy as a treatment for denture stomatitis

Conditions: Health Care Associated Infection

Summary: objective: this randomized clinical trial assessed antimicrobial photodynamic therapy (apdt) mediated by photodithazine (pdz) to treat patients with denture stomatitis (ds). methodologies: patients with ds were randomly assigned to the groups: apdt (n=30) and nystatin (nys, n=35). apdt patients received 6 apdt sessions, three times a week for 15 days, which involved pdz (200 mg/l) topical application (20 min) on the palate and upper denture, followed by light emitting diode (led) illumination (660 nm, 50 j/cm²). nys patients were instructed to rinse one dropper of this medication for one minute, four times a day, for 15 days. microbiological collections of dentures and palates were performed and cultured on blood agar and chromagar candida. microbial viability was determined, and photographs of the palates were taken for clinical evaluation. data were analyzed by repeated measure linear model and bonferroni (p≤0.05).


Eligibility criteria:
inclusion criteria: * edentulous denture wearers clinically diagnosed with denture stomatitis. exclusion criteria: * patients who received antibiotics, antifungal or steroids in the past 3 months prior to the beginning of the research, women in the reproductive phase, patients who had worn the same denture in the past 10 years, diabetics, anemics, immunocompromised and under cancer treatment.
trypan blue versus brillant blue for epiretinal membranes

Conditions: Idiopathic Epiretinal Membranes

Summary: membraneppeling alone versus membranepeeling with membrane limitans interna pelling using two different dyes for epiretinal membrane surgery.


Eligibility criteria:
inclusion criteria: * idiopathic eperetinal membranes * phakic or pseudophakic eyes * age over 60 years exclusion criteria: * secondary epiretinal membranes * severe ocular pathologies

Keywords: epiretinal membranes vitreoretinal dyes membranepeeling
visual distraction as a means of enhancing child resistance

Conditions: Unintentional Ingestion of Prescriptions Within Vials and Blisters

Summary: unintentional poisonings of children continues to be a major issue in the us. according to a study conducted by cincinnati children's hospital medical centers, during the period from 2001-2008, emergency room visits for children less than 5 rose 28% as the result of pharmaceutical products. the authors note, "the problem of pediatric medication poisoning is getting worse, not better." child resistant closures have been required on most medications sold in the us since the early 1970s. however, most designs attempt to thwart children through purely physical means (e.g. simultaneous dissimilar motion or opening using sequential tasks). few, if any designs, have utilized perception and cognition as a way to enhance child resistance. the investigators propose utilizing visual illusions in spaces distinct from the opening mechanism of prescription packages as a means of enhancing child resistance. in this project, visual illusion images are applied to both vials and wallet blisters in order to attract children's interest and prolong the time before opening. during stage i, the investigators will determine if the visual distractor attracts attention when samples are displayed in a storage rack. during stage ii, the investigators will test the effect of visual distractors on child resistance as measured by successful openings and time to open.

stage i objective: to determine if the visual distractor attracts attention when samples are displayed in a storage rack. eligibility criteria to participate in this study children must: * be 2 years to 4 ½ years old * have parent's permission to be videotaped * have parent's signed permission (in the form of the official (irb approved, signed consent) * have no known history of lactose allergy or lactose sensitivity (packages contain a lactose placebo) * verbally agree to participate after a brief explanation of what we want them to do outcome measures categorical variable (package choice) continuous variable (time to choice) stage ii objective: to test the effect of visual distractors on child resistance as measured by successful openings and time to open. eligibility criteria to participate in this stage of the study children must: * have no known history of lactose allergy or lactose sensitivity (packages contain a lactose placebo) * be 2 years to 4 ½ years old * have their parent's permission to be videotaped * have their parent's permission (in the form of the official, irb approved signed consent) * verbally agree to participate after a brief explanation of what we want them to do outcome measures binary (package opened yes/no) continuous variable (time to open for those successful)

Eligibility criteria:
inclusion criteria: * 2-4.5 years of age * parental permission to video tape exclusion criteria: * lactose allergy or lactose sensitivity

Keywords: poison control child resistant packaging prescription vials prescription blisters drug packaging
appetite regulation in children with failure to thrive

Conditions: Failure to Thrive

Summary: failure to thrive (ftt) is an expression for inadequate growth in the early childhood and thus, a sign of undernutrition. this study will include children with ftt, and compare with existing data from children with normal and excessive growth. the overall aim of this study is to explore whether 1) children who develop ftt with no organic explanation differ from healthy normal weight and overweight children in their basal level of appetite-regulating hormones and 2) if inadequate, normal and excessive growth in children can be partly predicted by variation in their gut microbiome and metabolome.


Eligibility criteria:
inclusion criteria: * diagnosed with failure to thrive * weight for height \> 1.9 sd below the median by use of the who child growth standards * age between 12-36 months exclusion criteria: * cancer * inflammatory bowel disease * celiac disease * immunodeficiency * other somatic disease that can explain the growth failure

Keywords: growth children appetite-regulating hormones gut microbiota
d-dimer adjusted versus therapeutic dose low-molecular-weight heparin in patients with covid-19 pneumonia

Conditions: Coronavirus Disease (COVID)19

Summary: evaluation of the efficacy and safety of d-dimer adjusted heparin versus therapeutic dose heparin in patients with covid-19 pneumonia.

the following will be done for enrolled patients: 1. data collection: name, age, sex, special habits of medical importance (i.e. smoking, drug abuse), comorbid conditions. 2. clinical examination vital data local chest examination 3. measurement of oxygen saturation using pulse oximeter 4. laboratory investigations: complete blood count with differential count liver and kidney functions d-dimer level coagulation profile 5. radiology work up ( chest x-ray-high resolution computed tomography of the chest- computed tomography of the chest with pulmonary angiography as needed) 6. sepsis-induced coagulopathy score (sic score) 7. sequential organ failure score (sofa score) 8. patients will receive treatment according to the hospital guidelines for different disease stratification severity

Eligibility criteria:
inclusion criteria: * all adult (\>18 years) patients from both sexes with covid-19 pneumonia with positive nucleic acid test for severe acute respiratory syndrome coronavirus (sars-cov-2) hospitalized either in the ward or intensive care unit exclusion criteria: * patients with absolute contraindication of pharmacological thromboprophylaxis and/ anticoagulation * congenital hemorrhagic disorders * hypersensitivity to heparin * personal history of heparin-induced thrombocytopenia * active major bleeding or conditions predisposing to major bleeding. major bleeding is defined as fulfilling any one of these three criteria: a) occurs in a critical area or organ (e.g.intracranial, intraspinal, intraocular, retroperitoneal, intra-articular or pericardial, intra-uterine or intramuscular with compartment syndrome), b) causes a fall in haemoglobin level (hb) of ≥2g/dl in a 24h period, or c) leads to transfusion of 2 or more units of whole blood or red blood cells (13). * suspected or confirmed bacterial endocarditis * ongoing or planned therapeutic anticoagulation for any other indication * platelet count \<50,000/μl within the past 24 hours or hb level \<8g/dl * prothrombin time (pt) ≥2 seconds above the upper limit of age-appropriate local reference range within the past 24 hours * activated partial thromboplastin time (aptt) ≥4 seconds above the upper limit of age-appropriate local reference range within the past 24 hours * fibrinogen \<2.0 g/l * severe renal impairment (crcl\<30 ml/min) or acute kidney injury * use of dual antiplatelet therapy * pregnancy * unwillingness to consent
genetic determinants of cardiovascular response to coffee drinking

Conditions: Caffeine

Summary: cardiovascular and neuropsychologic effects of coffee are still debated. the precise mechanism underlying the actions of caffeine on the cardiovascular and neuropsychologic systems is incompletely understood and a considerable variability in the response to coffee drinking was observed, in part ascribable to a genetic trait. the aim of the study is to evaluate acute cardiovascular and neuropsychologic effects of coffee and explore whether such effects are influenced by the genetic asset of caffeine metabolism (by a polymorphisms of cytochrome p450 1a2), adenosine metabolism (by polymorphisms of adenosine receptor and adenosine monophosphate deaminase) or catecholamine receptors (by polymorphisms of adrenergic receptors).

coffee is among the most widely consumed beverages worldwide. despite the relationship between coffee consumption and the incidence of cardiovascular disease has been studied extensively, the effects of this drink on the cardiovascular apparatus and its role as a risk factor for coronary heart disease are still debated. moreover, the effect of coffee on attention, sleep changes, anxiety and panic disorders was studied but a great variability was observed. many of the known or suspected cardiovascular and neuropsychologic effects of coffee have been attributed to caffeine. the main mechanism of action of caffeine is to antagonize adenosine receptors; a secondary effect is the inhibition of phosphodiesterases, with the subsequent accumulation of cyclic adenosine monophosphate and a intensification of the effects of catecholamines. it is also well known that there is a considerable variability in the cardiovascular and neuropsychologic response to coffee drinking, explaining the inconsistency between different effects observed in the various studies. this variability may have a genetic basis. the aim of the study is to evaluate acute cardiovascular and neuropsychologic effects of coffee and explore whether such effects are influenced by the genetic asset of caffeine metabolism (by a polymorphisms of cytochrome p450 1a2), adenosine metabolism (by polymorphisms of adenosine receptor and adenosine monophosphate deaminase) or catecholamine receptors (by polymorphisms of adrenergic receptors).

Eligibility criteria:
inclusion criteria: * age between 18 and 40 years * males (to avoid variation due to female hormonal cycle) * no known active ongoing disease (apparent good health) * non-smokers (to avoid contributory effects of nicotine or other tobacco alkaloids to caffeine effects or tolerance) * average coffee intake (not less than one cup/day and not greater than three cups/day) exclusion criteria: * treatment with any drug with known activity on the adrenergic system * hypertension * therapy with sympathomimetic drugs, theophylline, alpha- or beta-blockers, any antihypertensive therapy * body mass index (bmi) \> 30 kg/m2 (obesity) * bmi \< 18.5 kg/m2

Keywords: coffee caffeine blood pressure nutrigenetics gene polymorphisms acute cardiovascular and neuropsychologic effects
ropinirole xr (extended release) in patients with restless legs syndrome

Conditions: Restless Legs Syndrome

Summary: the purpose of this study is to assess the efficacy and safety of ropinirole xr in the treatment of adults with restless legs syndrome (rls).


Eligibility criteria:
inclusion criteria: * diagnosed with rls using the international rls study group diagnostic criteria with a total score of 15 or greater on the international rls rating scale. * have evening and nighttime symptoms of rls, significant sleep impairment due to rls symptoms, and symptoms requiring treatment prior to bedtime, but no earlier than 5:00pm. exclusion criteria: * have secondary rls. * have any medical conditions that may impact efficacy assessments or that may present a safety concern.

Keywords: restless legs syndrome rls
tracking breathing during sleep with non-contact sensors

Conditions: Sleep Apnea Syndromes; Snoring

Summary: the purpose of this study is to evaluate the feasibility of tracking breathing during sleep with non-contact sensors (for example, microphones or wireless movement sensors). the investigators will use the data collected with these sensors to develop algorithms for tracking breathing during sleep. the investigators will assess the performance of the algorithms by comparing automatic output against manually-generated labels.

subjects will be asked to place non-contact sensors (for example, ambient microphones, wireless movement sensors) in their home sleep environment. no sensors will be attached to or otherwise in contact with the subject's body. the subjects will start the data collection before they fall asleep, and stop the data collection the next morning when they wake. the subjects will then return the sensors to the investigator for analysis. the investigators will study the data and associated manual labeling. the investigators will develop algorithms that use statistical and machine-learning methods to train computer models designed to track breathing automatically. the investigators will compare the automatic output against manually generated labels to determine breath-tracking accuracy.

Eligibility criteria:
inclusion criteria: * age 21-89 * no self-reported sleep breathing problems exclusion criteria: * positive diagnosis for sleep breathing problem (e.g., obstructive sleep apnea)

Keywords: sleep apnea snoring
a randomized controlled trial evaluating sildenafil citrate in relieving ureteral stent related symptoms

Conditions: Quality of Life

Summary: despite its beneficial effect, ureteral stents may produce symptoms (such as hematuria, dysuria, frequency, urgency, urge incontinence and suprapubic or flank pain) that affect the quality of life in 70-80%. this study will be conducted to evaluate the role of phosphodiestrase 5 inhibitor (sildenafil citrate) in relieving these symptoms.

adult patient (\>18 years) who will undergo ureteral stent fixation after endoscopic procedures will be randomized between the study arms. exclusion criteria: 1. patients who had lower urinary tract symptoms before stent fixation. 2. ureteral stent fixation after open surgery. 3. known contraindications to sildenafil citrate

Eligibility criteria:
inclusion criteria: 1. patient aged \>18 years exclusion criteria: 1. patients who had luts before dj stent fixation 2. dj stent fixation after open surgery 3. contraindication to sildenafil citrate
china medical university hospital (cmuh) triapin listing

Conditions: Hypertension

Summary: the objective of this study is to compare the reduction in office seated systolic blood pressure (bp) following a 8 weeks regimen of ramipril 5mg plus felodipine 5mg versus ramipril 10mg. to compare the response rate (defined as office systolic blood pressure (sbp) / diastolic blood pressure (dbp) reduce more than 10mmhg from baseline), and bp controlled rate (defined as sbp\ 10%. to ascertain the safety and tolerability of ramipril/felodipine versus ramipril in taiwanese population. to compare compliance with fixed dose combination of ramipril/felodipine versus ramipril treatment.


Eligibility criteria:
inclusion criteria: * uncontrolled essential hypertension defined by office sbp/dbp \> 140/90 or \> 130/80 mmhg for compelling indications (diabetes mellitus, chronic kidney disease, known cad or cad equivalent or 10-year framingham risk score \> 10%) * previously untreated, or previously treated with a single antihypertensive therapy at usual dose during the last 4 weeks exclusion criteria: * female who are pregnant or breast feeding * office dbp\> 110mmhg or office sbp \>180mmhg * hypersensitivity to ramipril, felodipine or to any of the excipients * bilateral stenosis of the renal arteries, or unilateral stenosis in the single kidney * history of intolerance to any ace inhibitor * history of significant renal diseases including: serum creatinine \>3.0 mg/dl, or creatinine clearance \<30 ml/min * history of hereditary and/or idiopathic angioedema; or angioedema associated with previous acei * significant cardiovascular diseases, multiple drug allergies, bronchospastic disease or other malignancies requiring current medication * hepatic disease as indicated by any of the following: serum glutamooxaloacetate transferase (sgot) or serum glutamopyruvate transferase (sgpt)\>3 x upper limit of normal, or serum bilirubin \> 2 x upper limit of normal * any other condition or therapy that, in the investigator's opinion, or as indicated in the product(s) label may pose a risk to the patient or interfere with the study objective. the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
intraocular pressure fluctuation in patients with glaucoma and in healthy patients during standard yoga positions

Conditions: Glaucoma; Intraocular Pressure

Summary: the purpose of the study is to investigate the iop difference between normal and glaucomatous eyes using standard ophthalmic tonometry devices while subjects are performing different standard yoga asanas. the iop of participants will be measured prior, immediately at start of the asana, 2 minutes into the asana, and immediately after assuming a sitting position. the patient will wait 10 minutes and a final iop will be taken. four standard yoga asanas will be tested.


Eligibility criteria:
inclusion criteria: * glaucoma or healthy control * practice yoga * 18-80 years old * practice yoga for a minimum of 12 months exclusion criteria: * healthy subjects do not have normal ophthalmic exam * cannot maintain yoga positions