Kornimate/medical-research-clean huggingface dataset:
long-term nutritional support in patients with the acquired immunodeficiency syndrome: comparison of liposyn iii 2 percent with liposyn ii 20 percent

Conditions: HIV Infections

Summary: to compare two lipid emulsions in the long-term parenteral alimentation of patients with aids in relation to: clinical effectiveness. effect on immunologic function. effect on hiv load as measured by p24 antigen levels. effect on relative hiv infectivity.


Eligibility criteria:
inclusion criteria concurrent medication: allowed: * zidovudine (azt). * all drugs used for the standard treatment of opportunistic infections. * other drugs used for the treatment of other aids conditions if they have been started more than 3 months prior to study entry. patients must have: * diagnosis of aids. * weight loss of \> 10 percent premorbid body weight. * presenting diagnosis of either opportunistic infection or kaposi's sarcoma. * require home total parenteral nutrition (tpn) for a period of approximately 3 months. * life expectancy = or \> 90 days. prior medication: allowed: * zidovudine (azt). exclusion criteria co-existing condition: patients with the following conditions or symptoms are excluded: * life expectancy \< 90 days. * biliary stasis. * history of drug abuse. patients with the following are excluded: * life expectancy \< 90 days. * biliary stasis. * history of drug abuse. prior medication: excluded within 3 months of study entry: * immunomodulators. * experimental antiviral dt. history of drug abuse.

Keywords: weight loss parenteral nutrition, total aids-related opportunistic infections liposyn acquired immunodeficiency syndrome
is involucrin has a role in verruca vulgaris? a clinical and immunohistochemical study

Conditions: Verruca Vulgaris; Involucrin

Summary: vitamin d3 plays important role in keratinocyte differentiation and had been used recently in verruca vulgaris. aim of the work: to assess the expression of involucrin in verrucae vulgaris before and after injection of vitamin d3. subjects and methods: this study included 60 patients with verrucae vulgaris subjected to intralesional injection of vitamin d3 at three weeks interval for a maximum of five sessions. immunohistochemical assessment of involucrin was done before and after injection and compared to skin biopsies from 30 healthy individuals


Eligibility criteria:
inclusion criteria: patients with multiple verruca vulgaris patients with with verrucae vulgaris with size more than 3 cm exclusion criteria: patients with a past history of allergic response to vitamin d. pregnant or lactating females. hepatic patients. renal patients. patients with bleeding tendency.
the role of exercise training in the treatment of resistant hypertension

Conditions: Resistant Hypertension

Summary: the main purpose of this study is to assess whether exercise training reduces ambulatory blood pressure in patients with resistant hypertension. to accomplish these goals 60 patients with resistant hypertension will be recruited and randomized into exercise training or control groups and followed up for 6 months. the patients in the exercise group will participate in a 3-month outpatient program. the control group will receive usual medical care. at baseline, after the intervention and 3 months after the end of the intervention both groups will undergo several evaluations, including casual and ambulatory blood pressure, body composition, cardiorespiratory fitness, quality of life, arterial stiffness, autonomic function, and endothelial and inflammatory biomarkers.


Eligibility criteria:
inclusion criteria: confirmed resistant hypertension, who in the previous 3 months had unchanged medication exclusion criteria: 1. patients with secondary hypertension 2. evidence of target organ damage 3. patients with heart failure 4. previous cardiovascular event 5. peripheral artery disease 6. renal failure 7. chronic obstructive pulmonary disease 8. systolic office blood pressure superior to 180 mmhg 9. biomechanical limitations to physical activity 10. those participating in regular physical activity

Keywords: exercise training ambulatory blood pressure resistant hypertension nitric oxide
knowing and remembering: cognitive and neural influences of familiarity on recognition memory in early alzheimer's disease

Conditions: Alzheimer's Disease

Summary: unrandomized, unblinded, monocentric comparative functional magnetic resonance imaging study.

prospective functional magnetic resonance imaging study involving a group of participants with mild cognitive impairment due to ad and a control participants group matched for age, education level, verbal intelligence quotient as assessed through the french version of the national adult reading test and income group following national institute of statistics and economics studies classification.

Eligibility criteria:
inclusion criteria: volunteers (pilot phase) * aged 25 - 75 * french native speakers * right-handed * education level equal or superior to primary school leaving certificate * free from any medical or psychiatric condition that may impact cognition * having given written informed consent volunteers (experimental phase) * aged 60 - 75 * french native speakers * right-handed * education level equal or superior to primary school leaving certificate * free from any medical or psychiatric condition that may impact cognition * having given written informed consent ad-mci participants * aged 60 - 75 * french native speakers * right-handed * education level equal or superior to primary school leaving certificate * fulfilling criteria for " ad-mci " (albert et al., 2011) * have been seen in a memory medical center or in memory resources and research medical center for cognitive symptoms * free from any medical or psychiatric condition that may impact cognition * able to understand and consent * having given written informed consent exclusion criteria: mri contraindications (all participants) * claustrophobia * wearing of any metal implant such as: * heart pacemaker * iron-magnetic surgical clips * any metallic foreign body in the eye or brain other criteria (all participants) * significant history of neurological or psychiatric disorders * ongoing medication that may affect cognitive performances * sensory deficit that may interfere with the experimental design (e.g. uncorrected visual impairment) * lack of sufficient cooperation during the cognitive tasks * persons under major legal protection and/or deprived of liberty other criteria (control participants) - global cognitive impairment attested by mattis dementia rating scale or mini-mental state examination, according to available normative data other criteria (ad-mci participants) * 7 items modified hachinski ischemic score \> 2 (hachinski et al., 2012) * dementia (mckahn, et al., 2011)

Keywords: alzheimer, recognition memory, mild cognitive impairment, fmri
testing for covid-19 in high risk children with intellectual and developmental disabilities (cov-idd)

Conditions: Covid19

Summary: the purpose of this study is to understand how to prevent covid-19 spread in a school like the mary cariola center (mcc) in rochester, ny by answering questions like these: how do activities in the school alter chances of infection? are there people infected with the covid-19 virus who have no symptoms? how is spread of covid-19 affected by vaccination rates? is there any hesitancy to get the vaccine and what are the reasons? this information will be used to help keep the school open and the students and staff safe. eligible participants are those that work at the mary cariola center (mcc) and interact with the students at mcc who have a high risk of infection from covid-19. the study lasts for up to 16 months.


Eligibility criteria:
inclusion criteria: students: * idd student of the mary cariola center * age 3 - 18 * have a parent/guardian who can give informed consent * in the judgement of the mary cariola medical staff will be able to safely participate in the study procedures (nasal swab, phlebotomy) staff * age 18 - 72 * able give informed consent * anticipated duration of remaining employment less than 1 month (e.g. retiring) * must be willing to participate in rt-pcr and antibody testing exclusion criteria: students * contraindication to nasal swab * contraindication to phlebotomy (e.g. anticoagulated, bleeding diathesis) staff * contraindication to nasal swab * contraindication to phlebotomy (e.g. anticoagulated, bleeding diathesis)
spatiotemporal dimensions of metabolism in autochthonous tumors of gbm patients

Conditions: Glioblastoma Multiforme

Summary: to learn how altered metabolism in gbm causes tumor growth and resistance to drug therapy. in this pilot research study, we will dose gbm patients with a form of nicotinamide (a natural vitamin) that we can track. the nicotinamide will be converted to methyl nicotinamide (menam) in the tumor. we will measure how fast the nicotinamide is converted to methyl nicotinamide. we believe that the speed of this chemical reaction in the tumor (fast versus slow) may be correlated with gbm aggressiveness


Eligibility criteria:
inclusion criteria: 1. preoperative mri consistent with a primary intracranial malignant brain tumor. 2. must be 18 years of age or older. 3. patient eligible for debulking surgery/resection. exclusion criteria: 1. inability to obtain pre-operative iv access. 2. use of tru niagen, basis (or any other nicotinamide riboside (nr)-containing nad+ booster) or niacin supplements within one month prior to study visit 1. 3. participation in studies involving investigational drug(s) within 30 days prior to study visit 1 4. blood donation (excluding plasma donations) of approximately 1 pint (500 ml) or more within 56 days prior to study visit 1 (participants may not donate blood any time during the study, through the final study day) 5. presence of any condition that, in the opinion of dr. field, compromises participant safety or data integrity or the participant's ability to complete study days. 6. pregnancy, lactation or \< 9 months postpartum from the study visit 1 date.
identification of predictive factors for physiological hypermetabolism of the anal canal in 18f-fdg pet / ct

Conditions: Anal Cancer

Summary: questionnaire to be completed by patients coming for pet to identify the predictive factors of physiological hypermetabolism of the anal canal


Eligibility criteria:
inclusion criteria: * patient 18 years old * patient referred for 18f-fdg pet exclusion criteria: * history of surgery or anal and / or perineal and / or pelvic radiotherapy, whatever the indication * patient deprived of liberty, under tutorship or curatorship * any associated socio-educational, medical or psychological condition that could compromise the patient's ability to participate in the study (eg illiteracy, mental retardation, etc.) * pregnant woman (classic contraindication of a pet scan) * opposition of the patient to participate in the study

Keywords: tep hypermetabolism
partnerships to address covid-19 inequities

Conditions: COVID-19

Summary: this study evaluates the impact of an intervention to increase covid-19 prevention behaviors, including covid-19 testing. the intervention will be developed through a crowdsourcing contest.

a. the surge of covid-19 cases has been accompanied by glaring racial disparities in covid-19-related morbidity and mortality; disparities in outcomes have been most pronounced for african americans who, despite comprising only 13% of the us population account for about 30% of all covid-19 cases in states for which race-related data are reported. infectious disease modelers, epidemiologists, and other public health experts believe that covid-19 is here to stay and suggest that annual surges may persist through 2025 and beyond. with vaccine hesitancy and delay compromising our ability to attain herd immunity, the best means for controlling the spread of covid-19 according to public health experts is mass adoption of the 3 ws (wear a mask, wait 6 feet apart, and wash your hands) and increasing awareness of one's status through testing. as such, non-pharmaceutical interventions (npis) are currently our best options for viral control and containment. npis that are community-driven and developed in collaboration with diverse partners, including community members, public health agencies, and researchers may offer an acceptable and effective approach to reducing covid-19 transmission and addressing individual and socio-structural barriers that lead to worse covid-19-related outcomes among african americans. our study goals are to use a crowdsourcing open call to identify exceptional ideas (e.g., messages, videos, communication and dissemination strategies) that promote covid-19 testing and encourage the public to practice the 3 ws, referred to as health-promotive behaviors.

Eligibility criteria:
inclusion criteria: * specific zip codes in north carolina (specific zip codes to be determined) * no self-reported history of covid-19 infection * have not tested within the past 14 days exclusion criteria: * live outside of study area * under 18
naltrexone in the treatment of trichotillomania

Conditions: Trichotillomania

Summary: this is an 8-week, double-blind study of natrexone in the treatment of trichotillomania

the goal of the proposed study is to evaluate the efficacy of naltrexone in trichotillomania. forty subjects with dsm-iv trichotillomania will receive 8 weeks of double-blind naltrexone or placebo. the hypothesis to be tested is that naltrexone will be effective and well tolerated in patients with trichotillomania compared to placebo. the proposed study will provide needed data on the treatment of a disabling disorder that currently lacks a clearly effective treatment.

Eligibility criteria:
inclusion criteria: 1. men and women age 18-75; 2. current dsm-iv trichotillomania; 3. hair-pulling primarily due to urges/cravings; and 4) pulling is reported as pleasurable the majority of time. exclusion criteria: 1. unstable medical illness or clinically significant abnormalities on pre-study laboratory tests or physical examination; 2. history of seizures; 3. myocardial infarction within 6 months; 4. current pregnancy or lactation, or inadequate contraception in women of childbearing potential; 5. clinically significant suicidality; 6. current or recent (past 3 months) dsm-iv substance abuse or dependence; 7. illegal substance within 2 weeks of study initiation; 8. initiation of psychotherapy or behavior therapy from a mental health professional for the treatment of trichotillomania within 3 months prior to study baseline; 9. initiation of a psychotropic medication within 2 months prior to study inclusion; 10. previous treatment with naltrexone; and 11. treatment with investigational medication or depot neuroleptics within 3 months, with fluoxetine within 6 weeks, or with other psychotropics within 2 weeks prior to study baseline; 12. lifetime history of dsm-iv bipolar disorder type i, dementia, or schizophrenia or any other dsm-iv psychotic disorder; 13. current use of opiates.

Keywords: hair pulling
the cardiovascular and renal effects of moringa oleifera extracts and stevia rebaudiana bertoni in patients with type ii diabetes mellitus

Conditions: Benefits of a Capsules of Moringa Oleifera and Stevia Rebaudiana Bertoni in Patients With Type 2 Diabetes Mellitus Before and After 45 Days of add-on Therapy

Summary: the aim of the study was the evaluation of cardiovascular and renal benefits of moringa oleifera and stevia rebaudiana bertoni in patients with type 2 diabetes mellitus before and after 8 weeks of add-on therapy.

the investigators performed a non-randomized single-arm clinical trial with a before and after design, carried out from november 2016 and may 2017. intervention consisted of the administration of a daily consummation of 425 ml of drink containing the extracts of 1,38mg of leaves extracts of moringa oleifera and 23,46 mg of stevia rebaudiana bertoni leaves extracts lasting 45 days. before and after intervention, the following were done by the participants: bioelectrical impedance analysis (bia), blood pressure measurements, fasting blood sugar, hba1c, lipid profiles, liver function tests, kidney function tests, urinary excretion of albumin tests and full blood counts. these were followed by morphological workup including electrocardiograms (ecgs), transthoracic heart ultrasounds and ambulatory blood pressure measurements (abpm), also done before and after intervention. clinical evaluation with fasting blood sugar control, blood pressure controls and urinary excretion albumin tests were done for safety purposes.

Eligibility criteria:
inclusion criteria: * known t2dm patients aged above 21years * no change in anti-diabetic medication during the last three months hba1c between 42 to 64mmol/mol (6-8%) * clearance of creatinine calculated according to the modification of diet in renal disease equation\> 60ml/min/1.73 m2 exclusion criteria: * patient already on moringa or stevia supplementation or other herbal medication drugs that could interact with moringa or whose effects may be amplified, as far back as 1 month before study. * cardiac, renal disease and liver pathologies sensitivity, intolerance or allergy to moringa or stevia discontinued intervention * withdrawal of consent

Keywords: diastolic function blood pressure profile moringa oleifera stevia rebaudiana bertoni diabetes mellitus
a geriatric home visit program to reduce post-hip fracture complications

Conditions: Fracture; Infection; Depression; Gait Instability; Debility

Summary: the overall goal of the project is to reduce the incidence of post hip fracture morbidity and mortality by conducting geriatric fellow periodic home visits.the assessment will be multidisciplinary and will include assessments of functional status, depression, environmental risks and medical conditions. this group will be compared against a group followed by the usual standard of care post hip fracture.

all patients post hip fracture on the hospital's rehabilitation service that will be discharged to home will be enrolled after obtaining consent. patients will be randomized into the intervention group and the usual standard of care group.we will be recruiting a total of 100 patients , with equal numbers for each group.all patients will undergo an initial assessment by a geriatric fellow prior to discharge . the intervention group will be seen at the time of discharge in the hospital and at home at 1, 3, and 6 months post hip fracture. the control group will be seen at the time of discharge in the hospital and then again at 6 months for follow up. the two groups will then be compared for multiple known complications post hip fractures well as mortality.

Eligibility criteria:
inclusion criteria: * all post hip fracture patients on the hospital's rehabilitation service being discharged to home . exclusion criteria: * patients discharged to nursing homes or rehabilitation facilities.

Keywords: hip fracture postoperative complications depression environmental hazards fim scores falls
passive descent in obese nulliparous gravidae

Conditions: Management of the Second Stage of Labor in Obese Nulliparous Women by Either Passive Descent or Immediate Pushing.

Summary: obesity rates in reproductive aged women in the united states are rising. it is now universally accepted that obesity is associated with many adverse pregnancy outcomes and post-operative complications following cesarean section. recent studies have also shown an increased rate of cesarean section in obese women, adding to the already elevated rate of complications and adverse outcomes. given the increased a priori risk for obese patients, it is vital that the investigators reexamine management practices routinely used for normal weight women in this specific high-risk population. passive descent has been shown to increase the spontaneous vaginal delivery rate in non-obese women; however, high quality studies have never been performed in obese women. the investigators hypothesize that passive descent could improve the spontaneous vaginal delivery rate in nulliparous, obese women with regional anesthesia. this study will randomize women to passive descent for ninety minutes or active pushing upon entry into the second stage. further, given that passive descent is widely accepted in the midwifery literature and clinical practice, the investigators anticipate that a high-quality study in the physician literature could increase the dialogue between practitioners and lead to development of best practices in this high-risk population.


Eligibility criteria:
inclusion criteria: * obese - body mass index (bmi) calculated as weight (kg)/ \[height (m2)\] greater than or equal to 30 as determined at the time of admission to labor and delivery * regional anesthesia * nulliparous (defined as no deliveries after 20 weeks gestation) * gestational age of 37 0/7 weeks and greater * singleton pregnancy exclusion criteria: * body mass index (bmi) calculated as weight (kg)/ \[height (m2)\] less than 30 as determined at the time of admission to labor and delivery * no regional anesthesia * multiparous * gestational age of less than 37 0/7 weeks * multiple gestations * maternal fever prior to second stage * severe fetal anomalies (incompatible with life)
a comparative study on trans-umbilical single-port laparoscopic extra-peritoneal approach versus conventional repair for inguinal hernia in children

Conditions: Inguinal Hernia,Laparoscopy,Extra-peritoneal

Summary: inguinal hernia is a common disease in children. treatment of this disease by laparoscopic high ligation of the hernia sac has been accepted by domestic and foreign scholars. since laparoscopic inguinal hernia was introduced in 1990,it has now become the most commonly performed hernia repair in children. the conventional approach this is done with2small trocars to 1trocar . however the wound complications of infection and pain and the recurrent rate have not been resolved. the aim of the study was to described a new way of extra-peritoneal high ligation of hernia sac. this method combines the single-port laparoscopic could eliminated rate of wound complications and recurrence in inguinal hernia repair in children. the investigators hoped that this study will prove that the extra-peritoneal single-port laparoscopic repair is at least a s effective and efficient as the conventional technique in the cure of inguinal hernia and may results in lower recurrence and reduce incidence of wound complications.


Eligibility criteria:
inclusion criteria: unilateral inguinal herina age between 6 months and 13 years no history of abdominal or inguinal operations of male patients ,only those with completely descended testes were included exclusion criteria: the bilateral heina the recurrence herina