Kornimate/medical-research-clean huggingface dataset:
comparison of glycemic control with smartphone application

Conditions: Diabetes Mellitus

Summary: the study is aimed to determine if a smartphone application based weekly glucose monitoring by a care provider is superior to the routine home glucose monitoring by patients in poorly controlled type 2 diabetes mellitus who are on insulin.

the study is a randomized, prospective cohort study. subjects will be enrolled randomly after fulfilling the meeting criteria into two groups. group 1 (intervention group) will used mobile application to enter their glucose level and group 2 (control group) will record their glucose level on daily diary. data collection will be standardized in order to eliminate bias. in addition, all statistical analyses will be performed by a departmental statistician and not the study investigators. patients in each arm of the study will be selected form the same population in order to avoid selection bias.

Eligibility criteria:
inclusion criteria: * adult type 2 diabetes mellitus patients (≥ 18years of age) whose hba1c is ≥8% on insulin. * at least three months of daily home glucose monitoring before including in the study * willing to provide consent to participate in the study4. uses a smartphone with cellular network and willing to and has ability to learn and use the vivo vitals application on it. exclusion criteria: * patients who have gestational diabetes or type 1 diabetes * patients who have been admitted to the hospital in the last month for more than 3 days. * patients who have adrenal disorders or taking exogenous glucocorticoids. * patients who are mentally incompetent, having uncontrolled psychiatric conditions, inmates. * patients with active malignancies including those on treatment
laparoscopic single incision -vs- multiple incision gastric band surgery

Conditions: Surgery; Post-operative Pain; Post-operative Recovery

Summary: a double blinded randomised control trial comparing the differences between laparoscopic single incision versus multiple port bariatric surgery in morbidly obese patients (bmi\>35). single incision surgery is a new minimally invasive surgical technique requiring the surgeon to operate through one small single incision and is virtually scarless. the traditional laparoscopic approach to abdominal surgery is through multiple small incisions (4-7 ports) across the whole abdomen. this study seeks to identify the risks, benefits and costs of the adjustable gastric band insertion via single incision and multiple incision within the morbidly obese patient group.


Eligibility criteria:
inclusion criteria: * morbidly obese patients, bmi ≥35 kg/m2 * undergoing gastric band surgery * undergone a pre-weight loss surgery risk assessment * fit for anaesthesia and surgery * fulfil day surgery criteria * full understanding of bariatric procedure, with informed consent of the risks and benefits of laparoscopic single incision and multiple incision surgery exclusion criteria: * pregnancy * history of portal hypertension * previous gastric surgery or large hiatus hernia * previous laparotomy or bariatric surgery * weight \>150kg (day surgery limit) * unwilling to consider surgical treatment

Keywords: single incision surgery sils laparoscopic gastric band morbid obesity bariatric surgery
the effect of sleep hygiene education given in line with the health promotion model on sleep quality and menopause symptoms

Conditions: Absence of Menstrual Bleeding for at Least 12 Consecutive Months; No Communication Difficulties; Using a Mobile Phone; Becoming Literate; Not Using Sleeping Pills; Not Taking Any Supplements to Sleep

Summary: health promotion is defined as the behaviors that a person exhibits for a long-term and high-standard life. health promotion creates a sense of health in the individual, which makes the person feel more energetic and happy. the health promotion model primarily aims to treat the disease in the person. if the individual does not have a disease, their health is further improved. sleep is one of the basic needs required for a person to continue their life in a healthy way. some behaviors of people affect the quality and order of sleep. sleep hygiene is the daily activities performed to improve the quality of sleep during sleep. sleep hygiene education aims to avoid personal behaviors that affect a healthy sleep order and to exhibit behaviors that will positively affect sleep. menopause is defined as the permanent cessation of the menstrual cycle as a result of the ovaries losing their activity. menopause is one of the important stages of a woman's life. some physical and psychological changes begin to occur in women who lose their fertility and enter menopause. these changes are generally called menopausal symptoms. these symptoms are; menstrual irregularity, hot flashes, sleep disorders, tension and depression, etc. the research was planned as an experimental pre-test and post-test, and the data will be collected before and after the face-to-face training given by the researcher. the effects of sleep hygiene training given in line with the health promotion model on sleep have been investigated in the literature, but no study has been found examining the effects of sleep hygiene training given in line with the health promotion model on sleep hygiene and menopausal symptoms of women in menopause. therefore, it is thought that the research will contribute to the literature. the results obtained as a result of the study regarding the effects of sleep hygiene training given on sleep hygiene and menopausal symptoms will be taken into consideration by midwives.


Eligibility criteria:
inclusion criteria: * not having menstrual bleeding for at least 12 consecutive months * not having difficulty communicating * using a mobile phone * being literate * not using sleeping pills * not taking any supplements to sleep. exclusion criteria: * menstrual bleeding during the research period * the participant wants to talk about his/her research.

Keywords: menopause symptoms midwife sleep hygiene education sleep quality health promotion model
the effect of montelukast on difficulty in breathing after exercise in pediatric patients (mk0476-377)(completed)

Conditions: Exercise-induced Bronchoconstriction (EIB)

Summary: this study will see if there is a change in breathing after exercising when the child receives study drug ( montelukast or placebo). breathing will be measured by a spirometer before exercising and measured again several times after exercising.


Eligibility criteria:
inclusion criteria: * the child is 4 years to 14 years of age * the child is a non smoker * the child has exercise-induced bronchoconstriction (eib) exclusion criteria: * the child has active or chronic breathing disease, other than asthma * the child has required insertion of a breathing tube for asthma * the child had major surgery within the last 4 weeks * the child is currently in the hospital * the child has or had an upper respiratory tract infection within the last 2 weeks * the child has been hospitalized or visited the emergency room or had a change in their medication for asthma within the last 4 weeks * the child has been in a research study in the last 4 weeks * the child has stomach, brain, heart, kidney or liver disease * the child drinks more that 4 caffeinated drinks a day
open label extension study of epratuzumab in subjects with systemic lupus erythematosus

Conditions: Systemic Lupus Erythematosus

Summary: the primary objective of the study is assess the safety and tolerability of long-term epratuzumab treatment in subjects with systemic lupus erythematosus (sle)

treatment period was extended by 2 years to a total of 4 years and an amendment was prepared accordingly.

Eligibility criteria:
inclusion criteria: * subject has completed the double-blind study sl0009 (nct01262365) or sl0010 (nct01261793) or terminated prematurely at week 16 or later in sl0009 or sl0010 due to lack of efficacy and would, in the opinion of the investigator, continue to benefit from continued epratuzumab treatment * subject has completed open-label study sl0006 (nct00383513) or sl0008 (nct00660881), and would, in the opinion of the investigator, continue to benefit from continued epratuzumab treatment * women of childbearing potential must agree to use an acceptable method of birth control exclusion criteria: * subjects with active, severe, neuropsychiatric sle, defined as any neuropsychiatric element scoring british isles lupus assessment group index (bilag) level a disease * subjects with active, severe sle disease activity which involves the renal system * subjects with concurrent relevant medical conditions like defined chronic infections or high risk of new significant infections * substance abuse or dependence * history of malignant cancer * subjects with any other condition which, in the investigator's judgment, would make the subject unsuitable for inclusion

Keywords: lupus monoclonal antibody b-cell immunotherapy epratuzumab
doxorubicin alone versus atezolizumab alone versus doxorubicin and atezolizumab in recurrent cervical cancer

Conditions: Cervical Cancer

Summary: this is an open-label, multicenter, randomized phase ii trial to evaluate the safety and efficacy of atezolizumab in patients with recurrent cervical cancer in second line therapy. a total of 48 patients will be randomized in 3 arms, each arm consisting of 16 patients: arm a: atezolizumab monotherapy q3w arm b: atezolizumab combined with doxorubicin q3w arm c: doxorubicin monotherapy q3w


Eligibility criteria:
inclusion criteria: * squamous cell or adenocarcinoma of the cervix * at least one prior chemotherapy regimen for recurrent or advanced disease with a platinum-taxane combination, but not more than two lines of chemotherapy or targeted therapy in recurrent/advanced setting * measurable disease * ecog≤2 * adequate pretreatment hematologic, renal and hepatic function test * patients are allowed to have had bevacizumab during their prior treatment * evidence of non-childbearing status for women of childbearing potential exclusion criteria: * history of invasive malignancy other than cervical cancer unless there is no recurrence of these other primary tumors the last 3 years. * previous anthracycline-based chemotherapy * central nerve system metastases and leptomeningeal disease * active or history of autoimmune disease * prior allogenic bone marrow transplantation or prior solid organ transplantation * history of idiopathic pulmonary fibrosis * known positive test for hiv, or active hepatitis b or hepatitis c * known active tuberculosis * severe infection within 4 weeks prior to initiation of study treatment * prior immunotherapy
budesonide for maintenance treatment of collagenous colitis

Conditions: Collagenous Colitis

Summary: the purpose of this study is to determine whether orale budesonide is effective in maintaining clinical remission in patients with collagenous colitis.

the purpose of this study is to determine whether orale budesonide is effective in maintaining clinical remission in patients with collagenous colitis.

Eligibility criteria:
inclusion criteria: * collagenous colitis * diarrhea * written informed consent exclusion criteria: * infectious causes for diarrhea * other inflammatory bowel diseases * history of colonic surgery * celiac disease * malignancies * severe concomitant diseases * use of budesonide, steroids, mesalazine within the previous 2 weeks * known intolerance to budesonide * history of lack of response to budesonide * pregnancy,lactation * drug and/or alcohol abuse * lack of compliance

Keywords: collagenous colitis microscopic colitis budesonide
effect of gabapentin on idiopathic subjective tinnitus

Conditions: Subjective Tinnitus

Summary: the purpose of this study is to determine wether gabapentin which is useful for treating neuropathic pains, is effective on idiopathic subjective tinnitus.

tinnitus is the perception of sound in the absence of acoustic stimulation. it can be subjective or objective. . despite numerous researches,no effective treatment for people who suffer from tinnitus has yet been stablished. as there are many evidences suggesting that loss of inhibition in the central nervous system may be responsible for many aspects of auditory dysfunction,including tinnitus; and as gabapentin (neurontin), a gama-aminobutyric acid (gaba) analogue, is an effective medication in conditions where inhibition in the cns is impaired; we guess that gabapentin might be useful for treating idiopathic subjective tinnitus.

Eligibility criteria:
inclusion criteria: * patients with subjective idiopathic tinnitus exclusion criteria: * tinnitus with known underlying cause * pregnant women and patients younger than 18 or older than 75 years * patients with impaired renal function

Keywords: tinnitus gabapentin
re-training to effort (re) according to the severity of multiple sclerosis: preliminary assessments based on fatigue and quality of life

Conditions: Multiple Sclerosis

Summary: regular physical activity promotes physical and mental well-being in the general population. patients with multiple sclerosis (ms patients) tend them, to limit their physical activity or because of deficiencies related to the disease, or even on the advice of their caregivers in order to save their functional abilities. time for leisure activity could be almost 20% lower in ms patients compared to healthy controls, and this situation is likely to aggravate the functional symptoms of multiple sclerosis. the literature described the benefit of physical activity for ms patients according to protocols and varied assessments. evaluations were indeed concern very analytical elements of metabolic functioning, nervous, muscular, cardiopulmonary etc ... or take into account the performance of components or fatigue and quality of life. due to the multiplicity of re protocols, sometimes on the verge of pragmatic goals of functional rehabilitation, the double issue was the profit earned by an re program and of this benefit by level of severity of ms. the main objective of our study was an evaluation of the effects on fatigue and quality of life of a retraining program to effort suitable for levels of impairment and patients with ms activity limitations. the secondary objective was checking a performance improvement of the patients in this adapted program.


Eligibility criteria:
inclusion criteria: * patients necessarily declare fatigue perceived as annoying in everyday life. * basic electrocardiogram should be absolutely normal. * patients should subject themselves to regular participation in the re program exclusion criteria: * in the previous month the inclusion or during the re, the ms patients should not have presented thrust nor undergone intravenous chemotherapy, or have been in care center. * free of cognitive impairment.
diagnostic value of serum cathepsin s and chromogranin a in dkd

Conditions: Diabetic Kidney Disease

Summary: 1. evulate the diagnostic value of serum cathepsin s and chromogranin a for diabetic kidney disease. 2. to correlate the levels of serum cathepsin s and chromogranin a with hba1c and egfr in type 2 diabetic patients based on urinary albumin- creatinine ratio.

diabetic nephropathy (dn) is a common and serious complication of diabetes and has been shown to be a major cause of end-stage renal disease (esrd), requiring costly renal replacement therapy in the form of dialysis or transplantation . it is appreciated that up to 40% of patients with type 1 and type 2 diabetes mellitus (dm) present dn . early detection and appropriate treatment are essential to prevent disability and death. cathepsin s (cat-s) was a secreted cysteine proteolytic enzyme that is mainly expressed in macrophages. macrophages undergoing chemotaxis adhere to the basement membrane of blood vessels and secrete cat-s, and the secreted cat-s was involved in hydrolysis of elastin, laminin, collagen and other extracellular matrix components, causing vascular damage . so, cathepsin s(cat-s), a novel non-invasive diagnostic marker mediates vascular endothelial dysfunction. in recent years, studies have shown that up regulation of cat-s was associated with the development of iga nephropathy, lupus nephritis, insulin resistance, diabetes and other renal diseases. chromogranin a (cga) is the main member of the chromogranin family and is an acidic glycoprotein consisting of 439 amino acids with an approximate molecular mass of 48 kda. cga is used as a diagnostic marker of neuroendocrine tumors(6). the kidney is the main site for the removal of cga, and it is retained in serum with declining renal function. in patients with renal failure, serum cga increases much more than creatinine and the other studied low-mw proteins.

Eligibility criteria:
inclusion criteria: * patients diagnosed as type 2 diabetes mellitus * patients with t2dm with normoalbuminuria , microalbuminuria and macroalbuminuria. exclusion criteria: * renal impairment of other known origin, * type 1 d, * hepatic disease, * heart failure, * thyroid disorders, * autoimmune disorders, * inflammatory condition, * malignancy, * urinary tract infection, * pregnancy.
studying the skin microbiome and the potential of a topical probiotic cream for patients with acne

Conditions: Acne Vulgaris

Summary: in this study the topical use of cream with live probiotic bacteria was evaluated for its efficacy in reducing acne symptoms and its effect on the skin microbiota on patients with acne. patients with mild to moderate acne used the probiotic cream for 8 weeks and clinical evaluation and sampling was done at start, 4, 8 and 10 weeks. next-generation sequencing was used to analyze the skin microbiota of the patients.

probiotics are live micro-organisms which when administered in adequate amounts can exert a health benefit on the host. this health-promoting effects have been extensively studied in the gastrointestinal niche but it becomes more and more clear that other niches are also interesting for the potential of probiotics. recent breakthroughs in 'next generation sequencing' (ngs) technologies are making it now possible to map the microbiota after dna extraction, which is very interesting for bacteria that are not or difficult to cultivate. the research into the microbiota of the skin with such new ngs technologies currently limited, but shows that there is also an equilibrium in the skin composition of the microbiota and that there is a disturbance of the skin microbiota in acne (murillo \& raoult, 2013). in acne vulgaris it is known that the condition is multifactorial and that both hormonal triggers and environmental factors play a role. however, it is also known that propionibacterium acnes play an important role in the inflammation of the sebaceous gland follicles. probiotic strains with antipathogenic activity against this bacterium and suitable for application to the skin is thus potentially able to restore the balance of the skin microbiota and reduce acne symptoms.

Eligibility criteria:
inclusion criteria: * mild to moderate acne exclusion criteria: * local treatments, including cleansers, soaps, antimycotics and antibiotics within 2 weeks prior to start of study * use of oral antibiotics within 4 weeks prior to start of study * use of systemic retinoids within 6 months prior to start of study

Keywords: acne, comedonal, mild to moderate papulopustular acne
weaning from noninvasive ventilation

Conditions: Hypercapnic Respiratory Failure; Weaning Failure; Noninvasive Ventilation

Summary: noninvasive ventilation (niv) weaning strategies differ considerably from one another. these strategies have yet not been compared to each other. therefore, the investigators planned to perform a prospective, randomized, pilot study involving hypercapnic acute respiratory failure patients ready to be weaned off from niv. the investigators are going to compare the success rate of niv weaning and the duration of niv after randomization between 3 niv weaning methods: gradual decrease in duration of niv or level of ventilator support, and abrupt discontinuation of niv.


Eligibility criteria:
inclusion criteria: patients will be screened by the physician 24 hours (±6 hours) after initiation of niv treatment if: * age ≥18 years old * hypercapnic arf ( baseline ph\ 45 mmhg, borg\>4) * breathing frequency\< 25 bpm under niv * ph \>7.35 under niv * 10% or more decrease from baseline paco2 under niv * kelly ≤ 2 under niv (alert. follows simple/3 step complex commands) * pao2 between 60 and 70 mmhg under niv * no need for sedation * systolic blood pressure 90-180 mmhg without vasopressors * body temperature 36-38°c * heart rate 50-120 bpm the patient will be enrolled to the study and will be randomized to one of the niv weaning protocols, if passes daily weaning criteria listed below after 1 hour of spontaneous breathing (with supplementary oxygen), * respiratory rate 8-30 bpm * systolic blood pressure 90-180 mmhg without vasopressors * body temperature 36-38°c * heart rate 50-120 bpm * neurologic score of kelly ≤2 (alert. follows simple/ 3-step complex commands), * sao2 ≥88-92% with a fio2≤40%. * ph≥7.35 * absence of severe dyspnea (borg\>4). exclusion criteria: * age \<18 years old * niv use at home for chronic respiratory failure * cpap use for acute respiratory failure * niv use as palliative treatment * severe heart failure with cardiac index ≤ 2 l/min/m2 * severe hepatic failure with bilirubin ≥ 34.2µmol/l * severe renal failure with creatinine ≥ 220 µmol/l

Keywords: noninvasive ventilation respiratory insufficiency hypercapnia ventilator weaning
vibratory stimuli, a novel rehabilitation method for preventing post - traumatic knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: this study will evaluate the acute effects of vibration (whole body vibration and local muscle vibration) on quadriceps function, knee joint proprioception, and gait biomechanics linked to osteoarthritis development in individuals with anterior cruciate ligament reconstruction. subjects will be randomly assigned to control (no vibration), whole body vibration, and local muscle vibration groups, and the aforementioned characteristics will be assessed prior to and following the respective interventions.

quadriceps muscle dysfunction and proprioceptive deficits following knee injuries alter walking gait biomechanics in manners that contribute to development of knee osteoarthritis. current rehabilitation techniques are minimally effective for addressing these complications and preventing knee osteoarthritis. anterior cruciate ligament reconstruction dramatically increases the risk of knee osteoarthritis, and represents an ideal model for evaluating novel rehabilitation techniques for preventing knee osteoarthritis. direct (local muscle vibration) and indirect (whole body vibration) vibratory stimuli enhance quadriceps function and proprioception, and may improve rehabilitation and reduce the risk of knee osteoarthritis. the purpose of this investigation is to determine and compare the acute effects of whole body vibration and local muscle vibration on quadriceps function, knee proprioception, and gait biomechanics in individuals with anterior cruciate ligament reconstruction. the investigators hypothesize that vibratory stimuli will enhance quadriceps function, knee proprioception, and gait biomechanics in manners that would reduce the risk of developing knee osteoarthritis, and that whole body vibration and local muscle vibration will produce equivalent improvements in these characteristics.

Eligibility criteria:
inclusion criteria: * age 18-35 years * undergone unilateral aclr within 5 years prior to participation * at least 6 months post-aclr * knee injury and osteoarthritis outcome score (koos) self-report survey pain subscale score \> 53.1 and symptom subscale score \> 44.9 * cleared by a physician for return to physical activity, and currently participating in at least 20 minutes of physical activity 3x per week. exclusion criteria: * central activation ratio (car) \> 95% * history of acl graft rupture or revision surgery, neurological disorder, or injury to either leg within 6 months prior to participation (other than the initial aclr)

Keywords: anterior cruciate ligament reconstruction