Kornimate/medical-research-clean huggingface dataset:
contrast ultrasound perfusion imaging in pad with sonazoid

Conditions: Peripheral Artery Disease

Summary: the measurement of limb skeletal muscle perfusion and perfusion reserve during exercise is an approach that can assess the total impact of the complex pathophysiologic processes in patients with limb ischemia, particularly in those with diabetes in whom distal arterial disease and abnormal microvascular functional responses are common. this trial is designed to: (a) optimize methods for assessment of limb perfusion at rest and during stress using contrast-enhanced ultrasound (normal subjects) and a microbubble contrast agent that is able to provide non-linear signal without destruction at medium acoustic pressures, and (b) to test whether perfusion imaging provides incremental information on the severity of disease in patients with peripheral artery disease.


Eligibility criteria:
inclusion criteria: * for healthy controls: no active major medical problems or vasoactive medications * for pad: known diagnosis with pad an abi of 0.4-0.6 exclusion criteria: * rutherford class 6 or greater * allergy to ultrasound contrast agents * previous limb amputation * pregnancy * known congenital or acquired right to left shunt
amifostine in treating patients with ovarian epithelial cancer who are receiving chemotherapy

Conditions: Ovarian Cancer; Quality of Life

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. chemoprotective drugs such as amifostine may protect normal cells from the side effects of chemotherapy. purpose: randomized phase iii trial to study the effectiveness of amifostine in treating patients who have ovarian epithelial cancer and who are receiving chemotherapy.

objectives: i. determine if patients with ovarian epithelial cancer receiving chemotherapy have significantly fewer neurologic events when treated with amifostine. ii. compare amifostine vs no chemoprotection in terms of overall incidence of neuropathy, incidence of neutropenia, infection, and other myelosuppressive events (e.g., leukopenia, anemia, and thrombocytopenia), length of hospital stay due to infections, and quality of life in this patient population. outline: this is a randomized, parallel, controlled, double blind study. patients are randomized to one of two treatment arms. arm i: patients receive amifostine iv over 10 minutes, 30 minutes prior to chemotherapy. arm ii: patients receive a placebo iv over 10 minutes, 30 minutes prior to chemotherapy. treatment repeats every 3 weeks for 8 courses in the absence of disease progression or unacceptable toxicity. quality of life is assessed prior to courses 1, 4, and 8, and then every 3 months for 1 year. patients are followed monthly for 6 months. projected accrual: a total of 60 patients will be accrued for this study within 2 years.

Eligibility criteria:
disease characteristics: histologically confirmed, surgically staged ovarian epithelial cancer planned treatment with paclitaxel/carboplatinum chemotherapy patient characteristics: age: 18 and over performance status: gog 0-2 life expectancy: not specified hematopoietic: absolute neutrophil count at least 1,500/mm3 platelet count at least 100,000/mm3 hepatic: bilirubin no greater than 3 mg/dl sgot/sgpt no greater than 2.5 times upper limit of normal renal: creatinine no greater than 2 mg/dl other: not pregnant or nursing negative pregnancy test fertile patients must use effective contraception during and for 3 months after study prior concurrent therapy: biologic therapy: not specified chemotherapy: see disease characteristics no prior chemotherapy endocrine therapy: not specified radiotherapy: no prior radiotherapy surgery: see disease characteristics other: at least 24 hours since prior antihypertensives

Keywords: stage i ovarian epithelial cancer stage ii ovarian epithelial cancer stage iii ovarian epithelial cancer stage iv ovarian epithelial cancer quality of life
probiotics and multi-drug resistant urinary tract infection

Conditions: Urinary Tract Infections; Recurrent UTI; Antibiotic Resistant Infection

Summary: this pilot study is a single-site randomized, double blinded placebo-controlled in females with recurrent multi-drug resistant (mdr) urinary tract infections(uti). our study hypothesizes that a novel probiotic strain improves antibiotic sensitivity patterns in these former mdr utis.

the aims of this study are (1) to evaluate the effects of six months of probiotic therapy in addition to standard of care in changing sensitivity patterns of mdr bacteria causing recurrent uti, (2) analyze the genetic composition of mdr bacterial isolates causing recurrent uti before and after administration of probiotic vs. placebo, with standard of care antibiotics. study subjects will be asked to take a either a probiotic supplement or placebo at a dose of 1 caplet per day for 24 weeks in addition to antibiotic regimen. subjects will be followed for 12 months. the outcome measure is the percent of probiotic ingestors vs placebo ingestors who experience a change in antibiotic susceptibility over this time period. the secondary outcome measure is the evaluation of genetic composition of bacteria recurring after probiotic vs. placebo administration.

Eligibility criteria:
inclusion criteria: * female, age 18-90 * ability to void spontaneously * suffers from recurrent multi-drug resistant or extensively drug resistant urinary tract infections caused by e.coli, klebsiella, enterococcus, citrobacter, proteus, enterobacter, serratia and providencia. exclusion criteria: * has staghorn renal calculi, chronic hydronephrosis, intermittent catherization, indwelling urinary catheters, urinary diversions, end stage renal disease on hemodialysis, transplantation, hiv, cirrhosis, pancreatitis, allergy to soy or milk/milk proteins or lactose intolerance * pregnant or breastfeeding * currently taking probiotics. 4 week washout.

Keywords: probiotics multi-drug resistant uti recurrent uti
safety and effectiveness study of tumor cell-derived microparticles to treat malignant ascites and pleural effusion

Conditions: Malignant Pleural Effusion,; Malignant Ascites

Summary: malignant ascites and pleural effusion are common symptoms in patients with advanced cancer. currently, the management of malignant ascites and pleural effusion is a considerable clinical challenge. the investigator hypothesized that tumor cell-derived microparticles packaging chemotherapeutic drugs might be a useful means to treat malignant ascites and pleural effusion. thirty malignant ascites or pleural effusion patients will be recruited for phase ii clinical trials.

ascites or pleural effusion were first removed from patients. the patients were then locally injected with microparticles packaging chemotherapeutic drugs 4 times a week. the therapeutic effects and side effects were recorded.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of malignant ascites or malignant pleural effusion exclusion criteria: * non-malignant ascites or pleural effusion

Keywords: pleural effusion ascites malignant
effects of pelvic floor health education program in women with stress urinary incontinence

Conditions: Stress Urinary Incontinence

Summary: the aim of this study is to investigate the effects of pelvic floor health education program on urinary incontinence symptoms, knowledge level and quality of life in women with stress urinary incontinence.

stress urinary incontinence (sui) is the involuntary urinary incontinence that develops in parallel with the increase in intra-abdominal pressure and is seen in the absence of detrusor contraction. studies have shown that sui, leading to a decrease in the quality of life and worsening of social and health conditions, is more common in women than men. knowledge of pelvic floor health or urinary incontinence is generally low. low level of knowledge or wrong information limits patients' access to treatment. pelvic floor muscle exercise and lifestyle recommendations are also the first treatment options for sui. the information and awareness related to the pelvic floor and sui can be increase and unhealthy behavioral strategies can be modifiable through education programs. therefore the education programs related to the pelvic floor health would have positive effects on urinary incontinence symptoms, knowledge level and quality of life. studies about this issue are needed.

Eligibility criteria:
inclusion criteria: * being between the ages of 18-65 * women with stress urinary incontinence * those who volunteered to participate in the study * being literate exclusion criteria: * having advanced pelvic organ prolapse * having a malignancy * having a urinary tract infection * those who have a problem that interferes with cooperation and understanding
i-124 pet/ct imaging and dosimetry for rai-naïve or refractory thyroid cancer

Conditions: Thyroid Cancer; RAI-Refractory Thyroid Cancer

Summary: the objective of this study is to demonstrate the clinical utility of i-124 pet/ct imaging and dosimetry in patients with thyroid cancer including 1) evaluation of extent (volume and pattern) of remnant tissue in post total thyroidectomy setting and distinction of nodal metastases vs remnant tissue for determination of indication for rai ablation, 2) evaluation of response to rai remnant ablation, 3) evaluation for suspected occult recurrent/metastatic disease, 4) evaluation of extent of disease in patients with known metastatic disease and 5) evaluation of rai avidity of recurrent/metastatic thyroid cancer and response to treatment with thyroid kinase inhibitors (tki). patients who underwent total thyroidectomy for thyroid cancers are studied. patients who are newly diagnosed, as well as those who have known or suspected to have recurrent or metastatic disease are eligible. patients receiving tki treatment are eligible for evaluation prior to and after the treatment. the patients who are considered for tki/mapk treatments undergo pre and post treatment with clinically determined oncoprotein/tkr therapeutic agent(s), including multi-tki, selective braf, mek, pi3k or erk inhibitors or combination treatments.


Eligibility criteria:
inclusion criteria * post-total thyroidectomy patients with diagnosis of thyroid cancer, any histology, subtype, any ata risk category, for evaluation for residual disease, cervical or remote metastatic disease * patients with known or suspected recurrent/metastatic thyroid cancer, identified by ultrasound (us), ct/mr/fdg-pet\|ct or elevated thyroglobulin (tg). * pretreatment and post-treatment evaluation of patients with thyroid cancer deemed rai-indifferent/refractory who are considered for tki * age ≥ 18 * ability and willingness to give a written consent * life expectancy \> 3 months * ecog performance status ≤ 2 exclusion criteria * cancers metastatic to thyroid * age \< 18 * inability or unwillingness to give a written consent * life expectancy \< 3 months * ecog performance status ≥ 3 * pregnant and nursing women.

Keywords: thyroid cancer rai-refractory thyroid cancer redifferentiation therapy
evaluation of the subjectively perceived pelvic floor function in patients with gynecological tumors and breast cancer under systemic tumor therapy using a validated questionnaire

Conditions: Pelvic Floor Disorders

Summary: the multimodal therapy of gynecological malignancies and breast cancer often leads to an impairment of the pelvic floor function. this has a major impact on the quality of life of cancer patients. the aim of the study is to record and analyze the potential subjective impairment of the bladder, bowel and sexual function under systemic tumor therapy as well as possible influencing factors by means of validated disease-specific questionnaires. to find possible starting points for the prevention and treatment of the symptoms.


Eligibility criteria:
inclusion criteria: * breastcancer under tumor therapy * gynecological carcinoma under tumor therapy exclusion criteria: * none
improving consent and survey procedures for young msm in web-based hiv prevention

Conditions: Healthy

Summary: a two-part study to test the efficacy of alternative consent procedures and the efficacy of alternative methods to improve survey completion.

men who have sex with men are the risk population most heavily impacted by hiv in the united states by any measure; in 2009, at least 61% of new hiv infections were estimated to have occurred in msm. msm are experiencing an increase in hiv transmission that has been occurring since at least 1990, and accelerated in multiple north american and european countries from 2000-2005. the expansion of the hiv epidemic has been proposed to be attributable, in part, to the extent to which the internet has facilitated sexual connectivity among msm. researchers have attempted to reach msm for hiv prevention research and intervention on the internet. in the past 10 years, there has been a proliferation of internet surveys and hiv research studies among men who have sex with men that utilize the internet for data collection and, in some cases, the delivery of hiv prevention content. the development of internet-based interventions has been recently identified as especially promising because of its potential for scalability. however, there are also important limitations to internet-based data collections and prevention studies. the most important of these relate to representativeness and opportunities to introduce bias to data collections and differences in access to and use of internet among different subgroups of msm. equally important, although less discussed, are the unique ethical and human research protections challenges posed by online sexual health prevention studies. the investigators will conduct a series of experiments that will result in improved knowledge of how to conduct internet-based hiv prevention research with msm in ways that improve the protection of human subjects and decrease biases in data collections. the design will consist of preparatory online qualitative research with up to 100 msm, followed by two cross-sectional randomized controlled trials of msm recruited online; a total of 2440 msm will be enrolled in the two randomized quantitative studies (1,440 in study 1 to determine optimal methods to provide informed consent, online, and 1000 in study 2 to determine how to best improve retention in online surveys). about 2440 men will be enrolled in the study in total. this summary describes study 1; a separate submission will be completed for study 2.

Eligibility criteria:
inclusion criteria: * ages 18-34 * have had sex with another man in the past 12 months exclusion criteria: * female, transgender * younger than 18 years old * older than 34 years old * have not had sex with a man in the past 12 months
smoking dependence and periodontitis

Conditions: Smoking; Periodontitis

Summary: the present study was designed as a, single-center, prospective cohort study focusing on the relationship between smoking status and the severity of periodontitis

the present study was designed as a, single-center, prospective cohort study focusing on the relationship between smoking status and the severity of periodontitis. the research question was " how the fagerström for nicotine dependence (ftnd) and the number of cigarette cunsuption (nnc) are correlated to the severity of chronic periodontitis"? thirty-four consecutive smoker patients presenting a chronic periodontitis were included in the study, and the smoking status was defined both by ncc and ftnd. periodontal clinical parameters were correlated with ncc and ftnd. all the clinical periodontal parameters were recorded by a single periodontist (l.s). periodontal assessments included: probing depth (pd), gingival recession (rd), clinical attachment level (cal), bleeding on probing (bop), plaque score index (pi), furcation (furc), tooth mobility and the percentage of sites of pd ≥ 6mm. a graduated manual periodontal probe was used to take measurements at the 6 sites of each tooth. bop (%) and plaque score (%). all the participants of the study respected the following inclusion criteria: 1/ smoker patients aged of minimum 18 years old, 2/ chronic periodontitis, 3/ presence of a minimum of 6 teeth at each arch, 4/ a minimum of 6 teeth with pocket depth of 5 mm, 5/ signed the informed consent. the exclusion criteria were: 1/ aggressive periodontitis, 2/ diabetes, 3/ connective tissue disease, 4/ pregnancy, 5/ radio-therapy, 6/ chemotherapy, 7/ psychological disease, 8/ previous periodontal therapy. the patient smoking status was defined by ftnd and ncc ftnd scores were categorized in 3 groups * scores \< 4 for low nicotine dependence, * scores = 4-5 for moderate nicotine dependence * scores \> 5 for high nicotine dependence. the ncc s was classified in three levels of smokers as described in most of the periodontal studies: * number of cigarette smoking ≤ 10 per day for low consumption * number of cigarette smoking from 10 to 20 per day for moderate consumption * number of cigarette smoking \> 20 per day for high cigarette consumption

Eligibility criteria:
inclusion criteria: * smoker patients aged of minimum 18 years old * chronic periodontitis * presence of a minimum of 6 teeth at each arch * a minimum of 6 teeth with pocket depth of 5 mm * signed the informed consent exclusion criteria: * aggressive periodontitis * diabetes * connective tissue disease * pregnancy * radio-therapy * chemotherapy * psychological disease * previous periodontal therapy.
adrenal tumors - pathogenesis and therapy

Conditions: Adrenal Tumors; Adrenocortical Carcinoma; Cushing Syndrome; Conn Syndrome; Pheochromocytoma

Summary: the pathogenesis of adrenal tumors is still not fully elucidated and the treatment options for malignant tumors are poor. the current study investigates different aspects of the pathogenesis of adrenal tumors and evaluates different therapeutic options in patients with adrenocortical carcinoma.


Eligibility criteria:
inclusion criteria: * adrenal tumor detected by imaging exclusion criteria:
evolution of pulmonary ultrasound in patients hospitalized for covid (coronavirus disease) 19

Conditions: Pneumonia, Viral; COVID-19

Summary: clinical thoracic ultrasound plays an important role in the exploration, diagnosis and follow-up of thoracic pathologies. the covid (coronavirus disease) epidemic is leading to a large influx of patients in the emergency department with respiratory disorders. the rapid diagnosis of respiratory disorders in infected patients is important for further management. chest ultrasound has already demonstrated its value in the diagnosis of pneumonia in the emergency department with superiority over chest x-ray. however, there is little data on the thoracic ultrasound semiology of viral pneumonia in general and of covid in particular.

chest ultrasound has already shown its value in the diagnosis of pneumonia in the emergency department with superiority over chest x-ray. however, there is little data on the thoracic ultrasound semiology of viral pneumonia in general and of covid in particular. peng reported data from 20 patients and compared them to chest ct. the abnormalities are a thickening of the pleuropneumonia line, an interstitial syndrome with b lines, corresponding to frosted glass opacities, confluent b lines (snowstorm appearance) corresponding to interstitial infiltrate, sub-pleural alveolar opacities corresponding to sub-pleural condensations, more frank alveolar images corresponding to alveolar opacities. a multifocal aspect was associated with involvement of more than 2 lobes. however, the frequency of these abnormalities as well as the sensitivity of the echo are not detailed in this article. another italian article describes a clinical case of covid-19 pneumonia with sub-pleural involvement and irregularity of the pleuro-pulmonary line. clinical thoracic ultrasound has a major potential interest during the covid epidemic: available at the patient's bedside, avoiding the need to move around, feasible for the physician during his visit, easy to clean especially if ultraportable devices are used, fast and not exposing the staff any more than the usual clinical examination. in order to determine whether this technique is useful in the management of infected patients or patients suspected of covid-19 infection with respiratory signs, we propose a descriptive prospective study evaluating the ultrasound semiology of covid-19 pneumonia and the interest of ultrasound in the evolutionary follow-up of these patients.

Eligibility criteria:
inclusion criteria: * patients admitted to hospital with proven covid-19 infection with respiratory signs warranting a chest ct scan exclusion criteria: * patient not agreeing to have his or her data collected for the study * unconscious patient
oral morphine versus ketamine in pain management

Conditions: Pain, Procedural

Summary: the study will mainly focus on procedural pain management using oral morphine versus rectal ketamine during paediatric burn and wound dressing at mbarara regional referral hospital.

subjects will be randomly assigned to one of the two treatment groups a and b. guardians of patients who are scheduled for burn wound care will sign written consent pre- operatively about procedural pain management. group a will receive rectal ketamine while those in group b will receive only traditional standard of care protocols.

Eligibility criteria:
inclusion criteria: * pediatric patients between 6 months and 6-years old scheduled for a minimum of one procedure for burn wound dressing at the pediatric unit at mbarara regional referral hospital exclusion criteria: * children with rectal or anal pathology, * refusal to assent to participate or parental or guardian refusal to consent in the study * children who require mechanical ventilation or already intubated in intensive care unit * those allergic to ketamine or its constituents
effect of transcutaneous electrical nerve stimulation based on wrist-ankle acupuncture theory on postoperative pain after video-assisted thoracoscopic surgery

Conditions: Postoperative Pain; Video-assisted Thoracoscopic Surgery (VATS)

Summary: at present, surgical resection remains one of the main methods for the radical treatment of lung cancer. compared with traditional thoracotomy, video-assisted thoracoscopic surgery (vats) offers obvious advantages, such as less surgical trauma and rapid postoperative recovery. however, a certain proportion of patients will still experience moderate to severe pain after undergoing vats. postoperative acute pain can lead to increased postoperative pulmonary complications, prolonged hospital stays, and increased treatment costs. additionally, it is also associated with the development of postoperative chronic pain. therefore, effective pain management after vats is crucial. researchers will compare transcutaneous electrical nerve stimulation (tens) based on wrist-ankle acupuncture theory (tens-waa) with a sham stimulation regimen to determine whether tens-waa can relieve postoperative pain in patients undergoing thoracoscopic lung resection. this study aims to enrich the existing postoperative analgesia schemes and provide a reliable basis for its clinical promotion.


Eligibility criteria:
inclusion criteria: * patients aged over 18 years * american society of anesthesiologists (asa) physical status of i-iii * patients scheduled for elective unilateral lobectomy via video-assisted thoracoscopic surgery (vats) for lung cancer under general anesthesia * informed consent signed exclusion criteria: * history of liver, kidney, heart, lung, or brain disease * psychiatric disorder or cognitive impairment * chronic pain, daily use of analgesics, or alcohol dependence * routine or recent acupuncture treatment * contraindications to tens (with pacemaker or metallic implants, allergy to surface electrodes, with skin sensory disorders, skin ulceration, unhealed scars, or adhesions)

Keywords: video-assisted thoracoscopic surgery (vats) postoperative pain