Kornimate/medical-research-clean huggingface dataset:
the effect of +3.00add on myopia progression in chinese children

Conditions: Myopia

Summary: the purpose of this study is to evaluate the effect of +3.00add vs single vision spectacle on the progression of myopia in children. many studies applying bifocals or multifocal spectacles to intervene the progression have been carried out based on the idea that myopia was caused by excessive accommodation, however, the effect was limited. the possible reason is that bifocal or multifocal spectacles still not fully adjust the accommodative error in myopia children.

the optical intervention has been extensively explored for the intervention of myopia progression. based on the theory that myopia was caused by the excessive accommodative, bifocal or multifocal spectacles for slowing the progression of myopia have been fully studied. although some studies' results showed statistically significant for slowing myopia progression with multifocal spectacles, few had clinically meaningful, even in children with high accommodative lag or near-point esophoria. the investigators think that the possible reason for this clinical un-meaningful maybe that daily wearing bifocal or multifocal spectacles still not fully adjust the accommodative error in children. the aim of this randomized clinical trial is to evaluate myopic progression in children using two spectacles (single-vision spectacles for distant vision, and +3.00add spectacle for near vision), compared with control subjects wearing one spectacles (single-vision spectacles). myopia progression quantified by changes in axial length (al) and cycloplegic spherical equivalent refraction will be monitored for 3 years. the spectacles for intervention group children will be adjusted based on the cycloplegic spherical equivalent and the extent of accommodation lag for schedule time.

Eligibility criteria:
inclusion criteria 1. children who are aged 8 to 12 years (grade 3 and grade 4) from huadu district of guangzhou in china. 2. refractive error meeting all the following, obtained by cycloplegic autorefraction: spherical equivalent -1.00 to -6.00d in both eyes, astigmatism ≤2.00 d in both eyes, and spherical equivalent anisometropia ≤1.50 d. 3. the best corrected visual acuity is ≥ 6/9.5 4. the parents are willing to provide consent to participation in the study, and the children are willing to wear the only provided spectacles exclusion criteria 1. children who are allergy to tropicamide or topical anesthetic drugs. 2. children who had other eye diseases that cause the visual impairment including strabismus, amblyopia, ocular surface related disease, cataract, traumas, ocular fundus diseases, and ocular surgery. 3. children who were wearing rigid gas permeable contact lenses, progressive-addition lenses, bifocal spectacles lens, peripheral defocus modifying contact lenses; 4. children who are receiving visual function training.

Keywords: +3.00add single vision spectacle
the effect of short term amiodarone treatment after catheter ablation for atrial fibrillation

Conditions: Atrial Fibrillation

Summary: the purpose of this study is to examine the overall effectiveness of short-time anti-arrhythmic drug treatment with amiodarone (to control heart rhythm) to prevent short-and long-term atrial fibrillation following an ablation procedure for atrial fibrillation.

atrial fibrillation (af) is the most common cardiac arrhythmia, and it is associated with increased mortality and morbidity due to increased risk of stroke, poor quality of life and risk of developing heart failure. today, catheter ablation has become a standard procedure in the treatment of symptomatic atrial fibrillation, but so far there is no official recommendations regarding the use of antiarrythmic drugs after the procedure. nevertheless, it is common standard practice to prescribe antiarrhythmic drugs for the first 2-3 months after the intervention to prevent early recurrences. to our knowledge, the effect of antiarrythmic drugs following ablation for atrial fibrillation has only been evaluated in a few recent studies. none of these have evaluated the long term effect of short term antiarrythmic drug treatment. in addition, none of the trials have been conducted placebo-controlled. in this study patients with paroxysmal or persistent atrial fibrillation will be considered for randomisation. following the ablation procedure, patients will be randomized to receive either amiodarone or placebo for a period of 8 weeks. clinical visits including a physical exam, 12 lead ecg recording and blood samples, will be scheduled during the follow-up time. furthermore patients will be evaluated with quality of life questionaires and holter monitoring. the primary endpoint of the study is freedom from atrial fibrillation, atrial flutter or atrial tachycardia at 6 months follow-up.

Eligibility criteria:
inclusion criteria: * patients with symptomatic paroxysmal or persistent atrial fibrillation undergoing catheter ablation for atrial fibrillation. (persistent episodes may last no more than 12 months) exclusion criteria: * contraindication or intolerance to amiodarone. * prolonged amiodarone treatment within 3 months before the planned ablation procedure. * previous participation in this study. * other cardiac arrythmias (patients with co-existing atrial flutter can be included). * antiarrhythmic treatment for indication other than atrial fibrillation (or atrial flutter). * heart failure (nyha class iii or iv or left ventricular ejection fraction \< 35%). * significant heart valve disease. * significant lung disease, thyroid dysfunction or liver disease. * inability or unwillingness to be treated with anticoagulation before and during the study. * females with birth giving potential * failure to give informed concent.

Keywords: atrial fibrillation amiodarone arrhythmias, cardiac catheter ablation
efficacy of lanthanum carbonate in calciphylaxis

Conditions: Calciphylaxis

Summary: the research question and primary aim is to determine if lanthanum carbonate is effective in treating calciphylaxis by measurement of complete or partial remission of skin lesions. secondary endpoints will be measured to determine if lanthanum carbonate can lower calcium-phosphorus product levels, intact pth and mortality. albumin levels will be measured as a marker of nutritional status and inflammation.

calciphylaxis or calcific uremic arteriolopathy is an infrequently occurring although debilitating vasculopathy seen primarily in patients with end stage renal disease (esrd) which almost always affects the skin. it has a prevalence rate \~4 % in long term hemodialysis patients, with 1-year survival of 45% and an 8-fold risk of death as compared to the general dialysis population. (surgery 1997;122:1083-1089, kidney int 2001;60:324-332). despite being described in the literature for over 100 years, there has been no proven effective therapy. lanthanum carbonate (fosrenol®) is a potent non-aluminum, non-calcium phosphate binder that was approved for use to reduce serum phosphate levels in patients with end stage renal disease. since the proposed etiologic mechanism of injury and vascular calcification of calciphylaxis is predominantly hyperphosphatemia, elevated serum pth, and hypercalcemia, fosrenol® would be an ideal pharmacologic agent to utilize in this extremely enigmatic disease (dermatol clin. 2008 oct;26(4):557-68). furthermore, a recent case report demonstrated a significant improvement in laboratory parameters and calciphylaxis skin lesions with the use of fosrenol® (wmj. 2008 nov;107(7):335-8). the primary hypothesis is that since calciphylaxis represents the ultimate sequelae of metastatic vascular calcification predominantly involving hyperphosphatemia, elevated serum pth, and hypercalcemia, fosrenol® will be efficacious in its treatment.

Eligibility criteria:
inclusion criteria: * i participants will have signed a witnessed informed consent. ii participants will be greater than or equal to 18 years of age iii chronic renal failure receiving hemodialysis or peritoneal dialysis iv a diagnosis of calciphylaxis proven by skin biopsy or initial dermatology visit within the previous 5 year v serum phosphorus \> 4.5 mg/dl exclusion criteria: * i participants are not able to understand or provide written informed consent ii the research team deems that the participant may not be able to follow the study protocol. iii non-dependent hd patients receiving dialysis while in acute kidney injury; iv pregnant dialysis patient v active gastrointestinal obstruction or bleed vi active inflammatory bowel disease vii acute arteriovenous graft occlusion viii known hypersensitivity to fosrenol®

Keywords: calciphylaxis, dialysis
adapted eras in gynecologic oncology surgery

Conditions: Genital Neoplasm Malignant Female

Summary: background: in recent decades, the new concept of enhanced recovery after surgery (eras) program has been well accepted in the fields of gynecologic surgery. many studies have shown the effectiveness of eras protocol in reducing hospital's length of stay, patient's morbidity, and rate of postoperative complications while cutting back on health care cost. thus, standard guidelines such as acog has strongly recommended eras protocol implementation into each institution. however, institutions have self-limitations on adapting the standard eras pathway published from eras society due to the demand in resources. the concept of partial implementation of eras protocol has been raised and was mentioned in guidelines that eras implementation should be individualized to each institution. nevertheless, the effectiveness of adapted eras protocol itself has not been well researched. objectives: to examine the effect of partial implementation of eras protocol adapted to our institution on patient's recovery (based on hospital length of stay, pain score, time to flatulence, postoperative complications, and re-visits) compared to standard routine care in women diagnosed with gynecologic malignancy (cervix, endometrium, and ovary) undergoing elective open surgery. design: a randomized controlled trial in gynecologic cancers (cervix, endometrium, and ovary) women, age 18-75 years, undergoing elective open gynecologic oncology surgery at faculty of medicine, chiang mai university hospital. the participants will be randomly assigned into one of two study groups: intervention (adapted eras protocol) and control (standard routine care). for the intervention group, each woman will be brought through the adapted eras protocol step by step starting from preoperative counseling and preparation, intraoperative management, and postoperative management standard according to the adapted eras protocol. for the control group, each woman will be cared for using routine standard care. the primary outcome is length of hospital stay. 1.3 proposed duration 24 months


Eligibility criteria:
inclusion criteria: * 18 - 75 years old * diagnosed with gynecologic malignancy of cervix, endometrium, or ovary * elective laparotomy surgery exclusion criteria: * intraoperative accidental injury to urinary or gi organs * retain endotracheal intubation after surgery * peritoneal drainage for monitoring of bleeding/infection * unable to follow oral instructions * severe neuromuscular disease * preoperative hyperalimentation * neoadjuvant chemotherapy within 3 weeks prior to the procedure * previous abdominal/pelvic radiation * bowel obstruction * emergency operation
zero sodium peritoneal dialysate protocol pilot study

Conditions: Potential Applications for Heart Failure; Volume Overload

Summary: the following pilot study will be undertaken to determine the effects of use of a zero-sodium peritoneal dialysate solution (10% dextrose in sterile water) on sodium removal as compared to a standard peritoneal dialysis solution.

while heart failure (hf) is generally regarded as the inability of the heart to pump sufficient blood, on a population level, volume overload is the primary driver of morbidity and hospitalization. the signs and symptoms of volume overload are driven by water accumulation, which is initially driven by sodium retention. this overall goal of this study is to investigate the ability to remove sodium through use of a zero-sodium solution in peritoneal dialysis.

Eligibility criteria:
inclusion criteria: 1. patients actively undergoing peritoneal dialysis (pd) with a functioning pd catheter 2. pd vintage \< 3 years 3. as judged by treating nephrologist to be at or above optimal volume status (i.e., not dehydrated) exclusion criteria: 1. uncontrolled diabetes with frequent episodes of severe hyperglycemia 2. systolic blood pressure \< 100 mmhg 3. serum sodium \< 130 meq/l 4. 1 or more episodes of peritonitis in the previous 6 months or active infection of the peritoneal dialysis catheter 5. anemia with hemoglobin \<8 g/dl 6. serum bicarbinate \< 18 meq/l 7. anuric renal failure 8. inability to give written informed consent or follow study protocol

Keywords: peritoneal dialysis
do oral steroid dose packs predict how well epidural steroid injections will work?

Conditions: Lumbar Spine Disc Herniation

Summary: the purpose of this observational study is to show whether a standard oral steroid dose pack can be used as a screening tool to assess the effectiveness of a subsequent epidural steroid injection (esi). if an oral steroid does not give a patient significant temporary relief of pain from a herniated lumbar disc then an epidural steroid injection will not either. therefore the risk and expense associated from the interventional pain management procedure for those patients could be avoided and other treatment modalities pursued.


Eligibility criteria:
inclusion criteria: * 18 years and older * diagnosed by participating physicians during the study enrollment period as having intervertebral disk herniation and persistent symptoms with or without some nonoperative treatment for at least 4 weeks * radicular pain (below the knee for lower lumbar herniations, into the anterior thigh for upper lumbar herniations) * evidence of nerve-root irritation with a positive nerve-root tension sign (straight leg raise-positive between 30° and 70°) or a corresponding neurologic deficit (asymmetrical depressed reflex, decreased sensation in a dermatomal distribution) * undergone either mri or ct scan showing disc herniation (protrusion, extrusion, or sequestered fragment) at a level and side corresponding to the clinical symptoms * patients with multiple herniations can be included if only one of the herniations is considered symptomatic * preenrollment nonprocedural care can include: education/counseling, physical therapy, chiropractic therapy, anti-inflammatory medications, opioid analgesics, adjuvant analgesics such as anticonvulsants and antidepressants exclusion criteria: * prior lumbar surgery * cauda equina syndrome * vertebral fractures * spine infection or tumor * severe motor deficit * inflammatory spondyloarthropathy * pregnancy * cardiac or pulmonary comorbid conditions contraindicating interventional procedures * diabetes * inability/unwillingness to have spinal injections
the effect of bitter taste receptor agonists on the gastrointestinal tract, hunger and food intake

Conditions: Healthy; Obesity

Summary: in this study, the investigators aimed at evaluating the role of bitter taste receptors in the gastrointestinal tract (git). intragastric or intraduodenal administration of denatonium benzoate (db) or quinine hydrochloride were compared with placebo administration for their effects on lingual sensitivity, gastrointestinal motility (both in the fasted and fed state), gut hormone release (motilin, ghrelin, glucagon-like peptide-1 (glp-1) and cholecystokinin (cck)) and food intake. differences between lean and obese subjects will be evaluated.


Eligibility criteria:
inclusion criteria: * bmi\>30 kg/m² for the obese volunteers * bmi\<30 kg/m² for the lean volunteers * subject is capable and willing to give informed consent * female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception exclusion criteria: * female volunteer is pregnant or breastfeeding * gastrointestinal diseases, major abdominal surgery * major psychiatric illnesses * volunteers that use drugs affecting the git or the central nervous system (cns) * volunteers that suffer from diabetes mellitus * volunteers suffering from an endocrine disease such as diabetes, cushing's disease, addison's disease, hypothalamic tumor... * volunteers that have undergone surgical procedure for weight loss

Keywords: healthy volunteers obesity bitter
elemental diets vs. semi-solid diets on gastric excretion and gastroesophageal regurgitation

Conditions: Gastro-oesophageal Reflux

Summary: study 1: a randomized, crossover trial using elemental or semi-solid diets containing contrast medium as a tracer given to bedridden peg patients. the distribution of the administered diets is assessed at the distal esophagus, proximal and distal stomach using a plain ct before and 1 hour after the administration. study 2: a randomized, crossover trial using elemental or semi-solid diets containing 13c sodium acetate as a tracer given to bedridden peg patients. 13c breath tests are performed to estimate gastric emptying.

study 1: a mix of elemental or semi-solid diet (300 kcal/300 ml ) and contrast medium (5ml) is administered using peg, respectively. using a plain ct, the distribution of the administered diet is assessed at the distal esophagus, proximal and distal stomach before and 1 hour after the administration. the volume of the residual diet at the distal esophagus, proximal and distal stomach is compared between an elemental and semi-solid diet. study 2: either the elemental diet or semi-solid diet (200 kcal/200 ml) is labeled with 100 mg \[13c\]sodium acetate (cambridge isotope laboratories inc, cambridge, ma) and is administered in the first 15 min of the examination at the same speed using the peg.

Eligibility criteria:
inclusion criteria: * bedridden peg patients are admitted for fever which is the most common reason for admission of peg patients to our hospital. exclusion criteria: * regular use of gastric acid blockers, motility drugs, benzodiazepines or opioids, any clinical evidence of acute infection, a history of abdominal surgery, and an american society of anesthesiologists physical status of class iv or v.

Keywords: elemental diet semi-solid diet gastric emptying ger peg
mechanical ventilation reconnection for one hour after spontaneous breathing trial

Conditions: Airway Extubation; Ventilator Weaning

Summary: the aim of this study is to evaluate the feasibility to perform a future larger clinical trial to analyze whether the mechanical ventilation reconnection for 1 hour after a successful spontaneous breathing trial reduces the risk of reintubation or death at 7 days in participants with more than 72 hours of mechanical ventilation. the study will compare two weaning strategies in critically ill participants admitted to intensive care units, with more than 72 hours of mechanical ventilation and with a successful spontaneous breathing trial: 1. reconnection to mechanical ventilation for 1 hour followed by extubation; 2. direct extubation. follow-up will be until hospital discharge or death.


Eligibility criteria:
inclusion criteria: * age \> 18 years; * admission to the intensive care unit; * orotracheal intubation; * mechanical ventilation for more than 72 hours; * spontaneous breathing trial (according to the study protocol) successful and considered able to be extubated. exclusion criteria: * patients unable to obey commands; * unplanned extubation; * neuromuscular disease and cervical spinal cord injury; * tracheostomy; * contraindication for cardiopulmonary resuscitation or reintubation; * absence of informed consent.

Keywords: rest ventilator weaning airway extubation
heart failure registry

Conditions: Heart Failure, Congestive

Summary: the purpose of this registry is to compile a large clinical database on the medical management of patients hospitalized with acute heart failure, using information collected from acute care hospitals across the united states.

adhere is a phase iv, multicenter, observational, open-label registry of the management of patients treated in the hospital for acute heart failure (hf) in the united states. the target population consists of patients admitted to an acute care hospital who are treated actively for acute heart failure, where acute hf is defined as new-onset hf with decompensation; or chronic hf with decompensation. patient eligibility is based upon the presence of an acute hf diagnosis and is not tied to the use of any specific therapeutic agent or regimen. collect data on the episode of hospital care beginning with the point of initial care in the hospital and/or emergency department and ending with the patient's discharge, transfer out of the hospital, or in-hospital death. n/a

Eligibility criteria:
inclusion criteria: * received or is eligible to receive a principal hospital discharge diagnosis of hf or decompensated hf is present as determined clinically by the patient care team exclusion criteria: * heart failure is present as a co-morbid condition, but is not a principal focus of diagnosis or treatment during this hospitalization episode

Keywords: heart failure, congestive registry acute decompensated heart failure dyspnea
topical arnica and mucopolysaccharide polysulfate on postoperative pain, edema and trismus

Conditions: Impacted Third Molar Tooth

Summary: the present study was to evaluate the effect of topical arnica and mpsp application with respect to visual analogue scale (vas) scores, maximal interincisal opening (mio) and edema values after mandibular impacted third molar removal on days 1, 3, 5 and 10 postoperatively. the following null hypotheses of the present research were determined as follows: usage of topical agents would not influence i) vas scores, ii) mio values, and iii) edema values on 1st, 3rd, 5th, and 10th days after the mandibular impacted third molar surgery


Eligibility criteria:
inclusion criteria: * age between 16-68 years * american society of anesthesiologists (asa) class 1 physiological status * consistent radiological and clinical data * volunteered to participate in the study * scale ii" surgery difficulty according to modified parant classification for mandibular impacted third molar removal, be free of pericoronitis and infection at operation time exclusion criteria: * being out of age range * pregnancy or lactation * analgesic or antibiotic therapy history in last 14 days due to symptoms of related third molar * smoking cigarette * any pathology associated with impacted third molar * active complaints on preoperative examination on the day of surgery * immunosuppressed or diagnosed with malignancy * diagnosed chronic diseases such as; diabetes mellitus (dm), hypertension, cerebrovascular event, psychiatric diseases, coagulopathies * autoimmune diseases * patients who could not attend regular follow-up visits * allergy to the medications prescribed or utilized in study protocol * inconsistent clinical and radiological data or missed follow-up

Keywords: impacted third molar oral surgery edema trismus pain postoperative sequelae