Kornimate/medical-research-clean huggingface dataset:
comparison of automatic cpap to fixed cpap for osas following a prediction formula

Conditions: Obstructive Sleep Apnea Syndrome

Summary: comparison of automatic cpap with fixed cpap in patients with osas

the polysomnography is divided into two parts, randomly assigned: * in one part, the patient uses the automatic cpap device in titration mode * in the other part, the patient uses the cpap device, in fixed mode according to the prediction formula

Eligibility criteria:
inclusion criteria: * patients with proven obstructive sleep apnea syndrome * apnea-hypopnea-index \> 20/h * awaking index \> 30/h exclusion criteria: * severe nasal obstruction * hypoventilation * excessive sleep fragmentation caused by non-respiratory factors * copd (fev1/fvc \< 65%) * cpap compliance \< 3h per night * insufficient sleep time (\< 2h tst) during one of both parts of the split night cpap-titration * patients needing \> 16 mbar cpap pressures
effect of scapular mobilization on patients with scapular pain

Conditions: Myofascial Pain Syndrome

Summary: the purpose of this study is to determine the effect of scapular mobilization on pain related parameters including pain intensity, pressure pain threshold, muscle tension, anxiety, scapular range of motion, patient satisfaction in patients with scapular pain associated with myofascial trigger point:


Eligibility criteria:
inclusion criteria: * the participants have experienced spontaneous scapular pain for longer than 12 weeks (chronic) and that at least one trigger point will be present in the muscles surrounding the scapula. trigger points will be diagnosed as the presence of focal tenderness in a taut band and with pain recognition. * the participants will be able to follow instructions. * good communication and cooperation. exclusion criteria: * shoulder impingement syndrome * adhesive capsulitis * shoulder instability * shoulder arthritides * shoulder dislocation and/or bone fracture * hypermobility of shoulder joint * open wound * drug and/or alcohol intoxication * contraindications of mobilization
effectiveness of pulpotomy in the management of mature permanent tooth with irreversible pulpits

Conditions: Irreversible Pulpitis; Mature Teeth

Summary: this study is to evaluate the effectiveness of pulpotomy in mature permanent tooth with irreversible pulpits, and compare the clinical efficacy of pulpotomy and root canal therapy.

at present, root canal therapy ( rct ) is still the main treatment for mature teeth diagnosed as irreversible pulpitis, but the teeth after rct become non-vital, losing the immune defense mechanism and regeneration potential of pulp, which is not conducive to the long-term preservation of teeth. the traditional view is that mature permanent teeth with irreversible pulpitis are not indications for pulpotomy. however, with the deepening of pulp biology research and the availability of new pulp capping materials, the effect of pulpotomy is more predictable. recent studies have shown that pulpotomy for irreversible pulpitis teeth can achieve good results, however, there is a lack of high-quality randomized controlled clinical studies, and the effect of pulpotomy compared with rct studies rarely reported. therefore, this project intends to explore the curative effect of pulpotomy on mature permanent teeth with irreversible pulpitis, and analyze the influence of age, tooth position and other factors on its curative effect, broaden the indications of pulpotomy, and establish the indications and standardized operation process of pulpotomy for mature permanent teeth with irreversible pulpitis.

Eligibility criteria:
inclusion criteria: intended to participate with this study, and provide informed assent/consent. aged 18 and 59 years. at least one mature permanent teeth diagnosed as acute pulpitis or chronic pulpitis, and the teeth was in nolla stage 9 and above by radiographic examination. to be prepared to appear for follow-up. exclusion criteria: allergic to any medications or materials necessary to complete the procedures. the teeth with severe coronal defect that find to be non-restorable. the teeth with full crown restoration. the teeth with root fracture or vertical root fractures. patients with periodontitis. patients who are undergoing orthodontic treatment. patients with dental dysplasia or other oral genetic disorders. women who are pregnant or lactating, or women who plan to become pregnant in the subsequent 2 years. patients with mental disorders. patients with a history of systemic diseases that may alter immune function.

Keywords: pulpotomy root canal therapy
neurotoxic health hazards of long-term low-level exposure to organophosphate (op) compounds in in hula valley

Conditions: Peripheral Neuropathy

Summary: during 1987-1991, who supported studies of exposures and short term neurobehavioral effects in a cohort (n=200) with occupational and community exposures to pesticide drift containing organophosphates from orchards and cotton fields in the hula valley. we aim (1) to re-examine neurobehavioral outcomes in members of the original cohort and (2) to examine cognitive effects in children with residential exposures. in adults, we will carry out assays of alkyl phosphates, pon1 (paraoxonase-1), nte (neuropathy target esterase), neurobehavioral tests of cognitive and performance skills, nerve conduction measurements and mood status. we will carry out psycho-didactic tests in children. the findings will advance knowledge on delayed term health effects of lengthy everyday exposure to op pesticides and guide regulatory policy.


Eligibility criteria:
inclusion criteria: * participants of the former study twenty years ago

Keywords: op pesticides long-term low level exposure occupational health neurobehavioral effects
surgical versus nonsurgical treatment of fibular fractures: a prospective randomized study

Conditions: Ankle Fracture; Malleolus Fracture; Medial Malleolus Fracture; Bimalleolar Fracture; Trimalleolar Fracture

Summary: isolated surgical repair of the inside portion of the tibia may be enough to stabilize an ankle fracture in which both the tibia and the fibula are broken. this would alleviate the need for another incision, plate, and screws to repair the fibula. the purpose of this study is to help determine if surgically repairing only the tibia fracture will lead to equivalent clinical outcomes when compared with surgical repair of both bones. the hypothesis of this study is that operative stabilization of the medial malleolus fracture only, in otherwise ligamentously stable bimalleolar and/or trimalleolar fractures of the ankle, will lead to equivalent clinical outcomes and functional scores as those treated with operative stabilization of both malleoli and/or all malleoli.


Eligibility criteria:
inclusion criteria: * skeletally mature patients ≥ 18 years of age with acute, closed bimalleolar and/or trimalleolar ankle fractures * operative fixation of the ankle fracture is within 3 weeks from date of injury * bimalleolar and/or trimalleolar ankle fractures in which the medial malleolus fragment is greater than 1.7cm wide on lateral x-ray imaging * bimalleolar and/or trimalleolar ankle fractures in which the posterior malleolus fragment is less than 20% of the depth of the tibial articular surface exclusion criteria: * skeletally immature patients \< 18 years of age * single malleolar ankle fractures * open fractures * operative fixation of the ankle fracture is more than 3 weeks from date of injury * bimalleolar and/or trimalleolar fractures in which the medial malleolar fragment is less than or equal to 1.7cm wide on lateral x-ray imaging * bimalleolar and/or trimalleolar ankle fractures in which the posterior malleolus fragment is greater than or equal to 20% of the depth of the tibial articular surface * ankles with previous fractures of the medial and/or lateral malleolus requiring operative intervention

Keywords: outcomes surgical non-surgical ankle malleolus fracture tibia fibula bimalleolar trimalleolar
equine-assisted intervention on psychosocial adjustment in patients with psychiatric disorders

Conditions: Equine-assisted Therapy

Summary: the purpose of this study is to assess the efficacy of a brief equine-assisted intervention on the social adjustment, assertiveness, self-esteem and coping strategies in adult patients with psychosocial dysfunction, hospitalized and followed in psychiatry, as compared to standard care.


Eligibility criteria:
inclusion criteria: patients hospitalized in psychiatry with mental disorders lasting for more than 6 months with an egf score on the global evaluation of psychosocial functioning scale of between 31 and 60 at the time of inclusion. exclusion criteria: * acute psychiatric crisis * severe comorbidities (such as mental retardation, mental deterioration) which could invalidate informed consent or limit patient compliance with the study protocol. * medical contraindication to equine-assisted therapy (allergy, immunocompromised patients) * pregnancy * no affiliation to a social security scheme * deprivation of liberty by a judicial decision * wardship * horse phobia

Keywords: psychiatry psychosocial adjustment
non-drug interventions for migraines

Conditions: Migraine; Headache

Summary: this proposal describes a randomized controlled pilot trial investigating feasibility, safety, and migraine frequency in patients with migraines who undergo an 8 week mindfulness based stress reduction (mbsr) program compared to a wait-list control group.

preliminary research has shown mbsr to be effective in chronic pain syndromes and other mind/body interventions have shown good promise in the treatment of headaches. a randomized controlled trial (rct) of yoga in migraine without aura patients by john and colleagues showed that yoga resulted in a significant decrease in headache frequency, pain index, and symptomatic medication usage compared to a self-care group. this rct demonstrated that patients with headaches may benefit from a mind-body intervention. however, their yoga protocol was not specified, and participants were instructed to practice the technique only during the prodromal phase of a headache (prior to the pain becoming severe), so as an abortive intervention at the time of a headache. thus, the investigators of this trial are proposing to evaluate the effect of mbsr on adults with migraines compared to an education control group. this study will add to the john study because, unlike many other mind-body interventions, mbsr offers the distinct advantage of a standardized protocol that has been used both clinically and in numerous research studies across a wide variety of conditions. furthermore, mbsr teaches participants a daily practice that, if effective, could serve as a prophylactic intervention.

Eligibility criteria:
inclusion criteria: * diagnosis of migraine (international classification of headache disorders-ii);21 * 4-14 days with migraines/month * ≥one year of migraines * ≥18 years * able and willing to attend weekly sessions and willing to participate in daily mindfulness assignments, up to 30-45 min/day * agreeable to participate and to be randomized to either group * fluent in english (since the treatment groups will be run in english) * good general health with no additional diseases expected to interfere with the study exclusion criteria: * current regular meditation/yoga practice * any major systemic illness or unstable medical or psychiatric condition (e.g. suicide risk) requiring immediate treatment or that could lead to difficulty complying with the protocol * diagnosis of medication overuse headache (international classification of headache disorders-ii);19 * current or planned pregnancy or breastfeeding * new prophylactic migraine medicine started within 4 weeks of the screening visit * unwilling to maintain stable current doses of migraine medicines for the duration of trial * failure to complete baseline diary recordings of migraine activity and medication use

Keywords: migraines behavioral complementary and alternative medicine mindfulness meditation mindfulness based stress reduction
a study of commercial definity® to monitor the effects of the heart's pulmonary artery pressure

Conditions: Pulmonary Heart Disease

Summary: the purpose of this clinical research is to learn if definity® 416 will cause any adverse effects during right heart catheterization. this research was requested by the fda.

this phase iv safety study will provide safety data on potential systemic and pulmonary hemodynamic effects caused by the administration of definity® in patients who are to undergo right heart cardiac catheterization for clinical reasons. using a right heart catheter for direct measurements of pulmonary artery hemodynamics will allow accurate assessments of potential alterations of the pulmonary vasculature. this will be further investigated by the inclusion of two patient populations, one with a baseline pulmonary artery pressure \< 35 mmhg, and one with elevated baseline pulmonary artery pressure. the addition of immune parameter measurements will assess a potential link between systemic and pulmonary alterations and potential immune reactions following definity® administration. the inclusion of patients in this study is not based on a required echocardiogram with definity® administration because patients would be exposed to an unjustifiable risk of invasive right heart catheterization and are unlikely to consent to such a procedure. therefore, patients undergoing heart catheterization for clinical reasons, or patients who are undergoing pulmonary artery hemodynamic assessments will be enrolled and receive definity® in this study.

Eligibility criteria:
inclusion criteria: * appropriate candidate scheduled to undergo right heart catheterization and measurement of pulmonary artery hemodynamics for clinical reasons * be male or female above the age of 18 * female patients who no longer have child-bearing potential * women of child-bearing potential(wocbp) who: 1. are not pregnant and have been using an adequate and medically approved method of contraception 2. have a negative urine pregnancy test * be able and willing to communicate effectively with study center personnel. exclusion criteria: * women who are pregnant or lactating * known hypersensitivity or contraindication to or greater heart block * previous heart transplant * known right-to-left shunt (including atrial septal defect) * severe pulmonary artery hypertension (i.e., \> 75 mmhg * current uncontrolled ventricular tachycardia * second-degree or greater heart block * any contraindications for the use of a right heart catheter

Keywords: phase 4 definity® hemodynamics pulmonary artery pressure
next-generation sequencing of colorectal cancer somatic cells to guide genetic susceptibility gene mutations screening.

Conditions: Hereditary Colorectal Cancer

Summary: this is a prospective, single-center, clinical study.this study is to evaluate the feasibility of genetic susceptibility screening based on the detection of tumor tissue mutations by a ngs panel.

in this study, gene mutation profiling was performed on primary tissue samples from colorectal cancer patients who met relevant clinical screening criteria, unearthing suspected germline pathogenic mutations. at the same time, germline mutation detection was performed on peripheral blood leukocytes of patients, and the consistency between suspected germline mutations in tumor somatic mutation detection and control leukocytes was compared. establishing the feasibility of tumor somatic mutation-based detection to guide genetic susceptibility screening.pedigree verification will be carried out for blood relatives of patients with germline mutations which have been identified for colorectal cancer.through the tumor somatic and germline gene mutation profiles of chinese hereditary colorectal cancer patients, it reveals the molecular characteristics of hereditary colorectal cancer in asian populations and provides molecular-level evidence for possible subsequent clinical diagnosis and treatment.

Eligibility criteria:
inclusion criteria: * a biopsy proven histological diagnosis of colorectal carcinoma. * ≥ 18 years of age on the day of signing informed consent. * patients must meet the relevant clinical screening standards, such as the amsterdam standard (i / ii),etc. * patients need to provide tumor tissue samples and matched peripheral blood (leukocyte) samples. exclusion criteria: * history of other malignant tumors(except for cervical carcinoma in situ, basal or squamous cell skin cancer which has been fully treated). * there is no detailed histopathological report to judge the nature of the lesions. * any social or psychological problems, etc., which are judged by the researcher to be unsuitable for the study. * for various reasons, the baseline samples (tumor tissue samples, peripheral blood samples) were incomplete. * patients who are unwilling or unable to follow the research program for long-term and regular follow-up in current medical institutions. * failure to complete the follow-up within 2 years.

Keywords: colorectal cancer next-generation sequencing genetic susceptibility
protozoans in biofilm from patients with periodontitis

Conditions: Periodontitis, Adult

Summary: the buccal cavity is colonized by numerous microorganisms whose the number and composition could be modified with medical background (diseases and drugs) and the level of oral hygiene of the patients. among all microorganisms identified in the periodontium, few of them are implicated in the etiopathogenesis of periodontal pathologies. to date, four major bacteria are identified for their ability to degrade periodontal tissues. although the periodontitis is established to be the consequence of bacterial virulence and immune dysfunction, these factors fail to explain the refractory periodontitis of some patients to etiologic treatment . others microorganisms such as protozoans could have an impact on this disease.


Eligibility criteria:
inclusion criteria: * adults \> 18 years-old * consulting in periodontal department of chru * patients with moderate to severe periodontitis * at least 2 periodontal sites with ppd ≥ 5mm and one healthy site * no scaling root planing in the last 6 months * patients insured under the franch social security system exclusion criteria: * pregnants patients * patients with antibiotic therapy and/ or all medecines which could modify the buccal microbiota in the last 6 months * tooth with endodontics periapical lesion * patients having a scaling root planing in the last 6 months * patients with guardianship
ipd meta-analysis of de-escalation treatment strategy after pci in acs

Conditions: Acute Coronary Syndrome; Coronary Artery Disease

Summary: we will perform a systemic review of previously published data and an updated patient-level meta-analysis of studies, including the most recent publications. pubmed, embase, cochrane central register of controlled trials, the united states national institutes of health registry of clinical trials, and relevant websites were searched for pertinent published studies.

this is an individual patient-level data meta-analysis (ipd meta-analysis). this study population was incorporated from studies that were previoiusly published. we will perform a systemic review of previously published data and an updated patient-level meta-analysis of studies, including the most recent publications. pubmed, embase, cochrane central register of controlled trials, the united states national institutes of health registry of clinical trials, and relevant websites were searched for pertinent published studies. the electronic search strategy was complemented by manual examination of references cited by included articles, recent reviews, editorials, and meta-analyses. no restrictions were imposed on language, study period, or sample size. the search keywords include "acute coronary syndrome", "acs", "primary", "percutaneous coronary intervention", "pci", "de-escalation", "guided", "guide", "antiplatelet", "p2y12 inhibitor", "p2y12", "dual antiplatelet therapy", "dapt". articles were included when they met the following prespecified criteria: (1) included the acs patients who underwent pci with drug-eluting stent (des); (2) maintained dapt for 1 year; (3) de-escalation strategy of dapt was clearly defined; (4) clinical outcomes, including ischemic and bleeding events, were clearly reported; (5) randomized controlled trials were considered for inclusion. two independent investigators screened titles and abstracts, identified duplicated studies, performed full-article reviews, and determined the study inclusion. the third investigator supervised the searching process and adjudicated all the disagreements. after selecting eligible rcts, we will incorporate all known randomized controlled trials requesting individual patient data from the principal investigator of each trial.

Eligibility criteria:
this study is a meta-analysis of previously published studies. therefore, the eligibility criteria may be diverse according to the individual studies. -------------------------- inclusion criteria: * subject must have clinical diagnosis of acute coronary syndrome exclusion criteria: * the patient has a known hypersensitivity or contraindication to any of the following medications: heparin, aspirin, clopidogrel, prasugrel, ticagrelor

Keywords: percutaneous coronary intervention dual antiplatelet therapy de-escalation
intravenous beta-blockade for improvement of autonomic activity

Conditions: Hypertension; Tachycardia; Heart Rate Variability

Summary: chronic beta-adrenoceptor blockade is known to improve outcome of high risk patients whereas amelioration of autonomic activity was demonstrated to be a major cause of outcome improvement. therefore, perioperative beta-adrenoceptor blockade is recommended in patients with revised cardiac risk index score of three or greater. the investigators hypothesise that preoperative intravenous beta-adrenoceptor blockade for treatment of hypertension and/or tachycardia improves autonomic activity reflected by increase of total power of heart rate variability. material and methods: after irb approval 20 patients scheduled for elective cardiac surgery were included into the study. routine medication was continued throughout the study as recommended by the guidelines. hrv (tp and low to high frequency ratio (lf/hf) reflecting sympathetic to parasympathetic balance) was analysed prior to induction of general anesthesia and beta-adrenoceptor blockade in all patients (baseline). patients were assigned by their baseline hemodynamics. patients with hypertension (systolic blood pressure \> 140mmhg or diastolic blood pressure \> 90mmhg) or tachycardia (heart rate \> 80bpm) were assigned to group beta-block. in this group metoprolol-boli (2mg) were administered intravenously in stepwise manner until hemodynamic values decreased to normal. total dosage was recorded. after normalisation of hemodynamics, second hrv analysis was performed (intervention). normotensive and normocardic patients were assigned to group control. no intervention was performed. statistics: mann whitney u test for comparison between groups and between events baseline and intervention within group beta-block, p\<0.05.


Eligibility criteria:
inclusion criteria: * patients scheduled for coronary artery bypass surgery * ejection fraction \> 30 % * informed consent exclusion criteria: * emergency cases * myocardiac infraction within 4 weeks

Keywords: outcome assessment, patients; autonomic nervous system; perioperative care; adrenergic beta antagonist autonomic regulation perioperative beta-blockade outcome