Kornimate/medical-research-clean huggingface dataset:
effects of prescription omega-3 acids on glucose and lipoprotein lipids in subjects with hypertriglyceridemia

Conditions: Hypertriglyceridemia

Summary: the objectives of this study are to assess the effects of 4 g/d prescription omega-3 acid ethyl esters (pom3), compared with a placebo, on indices of insulin sensitivity and secretion, as well as aspects of the fasting and postprandial lipid and lipoprotein profiles, in subjects with hypertriglyceridemia.

this trial will utilize a randomized, double-blind, two-period crossover design. at visit 2 (week 0), subjects meeting all entry criteria will be randomized to one of two treatment sequences: placebo or pom3 for the first 6 week phase followed by the study product they did not receive during the first phase (pom3 or placebo) for the second 6 weeks. there will be a 2-week washout period between treatment phases.

Eligibility criteria:
inclusion criteria: * men and postmenopausal women, ages 18-79 years. * fasting, triglyceride (tg) level in the borderline high to high range. * fasting, low density lipoprotein cholesterol (ldl-c) below the very high range while on no lipid altering therapy or while taking stable-dose statin therapy * provide written informed consent and authorization for protected health information exclusion criteria: * use of any lipid-altering medications, which cannot be stopped, except stable dose statin therapy. * use of any omega-3 fatty acid ethyl ester medications or dietary supplements with \>1.0 g/d of eicosapentaenoic acid (epa), docosahexaenoic acid (dha), or a combination of epa and dha * coronary heart disease (chd) or a chd risk equivalent * body mass index over 45 kg per square meter * allergy or sensitivity to omega-3 fatty acids, corn or corn products (e.g., corn oil), d-alpha tocopherol (vitamin e) or any ingredients in the study drug * certain muscle, liver, kidney, lung or gastrointestinal conditions * poorly controlled hypertension * certain medications * active cancers treated within prior 2 years (except non-melanoma skin cancer)
intralipid for recurrent miscarriage

Conditions: Abortion, Spontaneous; Abortion, Habitual

Summary: intralipid infusion can improve the outcome in nk cells positive females with history of recurrent miscarriages undergoing ivf/icsi cycles.


Eligibility criteria:
inclusion criteria: * couples with unexplained secondary infertility * three or more prior consecutive clinical miscarriages after either spontaneous pregnancy or after ivf/icsi. * elevated natural killer (nk) cells cd16, cd56 and cells with both cd16/cd56 \>12%. exclusion criteria: * age above forty years old. * antiphospholipid syndrome (lupus anticoagulant and/or anticardiolipin antibodies \[igg or igm\]); other recognised thrombophilic conditions (testing according to usual clinic practice). * intrauterine abnormalities (as assessed by ultrasound, hysterosonography, hysterosalpingogram, or hysteroscopy). * abnormal parental karyotype. * other identifiable causes of recurrent miscarriages (tests initiated only if clinically indicated) e.g., diabetes, thyroid disease and systemic lupus erythematosus (sle). * disturbances of normal fat metabolism such as pathologic hyperlipemia * allergic to it; or to eggs, soybean oil, or safflower oil. * severe liver disease, kidney disease, lung disease, anemia, blood clotting disorder.

Keywords: recurrent miscarriage implantation failure intralipid icsi / ivf failure
photochemical tissue bonding

Conditions: Basal Cell Carcinoma; Squamous Cell Carcinoma; Atypical Nevus

Summary: the broad aim of this study is to evaluate the efficacy of photochemical tissue bonding (ptb) for the closure of skin excisions. we will test the hypothesis that full thickness skin excisions treated with ptb can heal with less scarring than those treated with the conventional suture closure method.

hypertrophic scarring is a frequent endpoint after traditional surgical excision of skin cancers of the chest. these scars create significant long-term morbidity to the patient. there is a clinical need for an alternative treatment that would reduce factors associated with hypertrophic and possibly keloid scar formation by providing minimal tension, low infection risk and an absence of foreign body material. this would result in a normal appearing and healed scar without associated patient morbidity. photochemical tissue bonding may provide this alternate treatment. ptb differs from sutures by continuously joining the tissue surfaces on a molecular level rather than only at discrete suture points. in addition, ptb does not incite foreign body reactions nor create tissue injury during passage of the needle and tying a knot, injuries that may initiate scarring.

Eligibility criteria:
inclusion criteria: * histopathology confirmed basal cell carcinoma or well-differentiated squamous cell carcinoma without subcutaneous fat invasion on the chest, arm or abdomen or a diagnosis of atypical or dysplastic nevi on the chest, arm or abdomen. * able to follow involved post-operative care instructions * able to comply with study requirements * age 20-60 years exclusion criteria: history of underlying photosensitivity condition skin phototypes v-vi use of photosensitizing medication history of accutane use within the past 12 months history of underlying bleeding disorder or use of anticoagulant (e.g. coumadin) active smoker known pregnancy or lactating mother allergies or reactions to lidocaine or epinephrine underlying immunodeficiency inability to comply with study requirements pacemaker or defibrillator in place

Keywords: skin cancer skin excision laser superficial sutures wound healing
photobiomodulation for dry age related macula degeneration

Conditions: Photobiomodulation; Age-Related Macular Degeneration

Summary: the study will investigate the effect of photobiomodulation treatment on the risk of developing late age related macula degeneration (amd) in the study eye in patients with wet amd in the fellow eye.


Eligibility criteria:
inclusion criteria: * patients with dry amd in the study eye and wet amd in the control eye exclusion criteria: * geographic atrophy of the central macular region at enrolment * previous/ active wet amd in the study eye * a history of epilepsy * retinal diseases apart from amd * significant media opacities * cataracts worse than grade 2 (locs iii classification) * change in areds 2 supplements (vitamins) 1 month before the study and during the study trial was allowed. * ongoing systemic medications that are photosensitizing (e.g. tetracyclins) * systemic medications during the last 6 months that can cause deposits in the macular region (hydroxychloroquine, amiodarone) * unable to give informed consent * unable to cooperate with the treatment and follow-up

Keywords: choroidal neovascular membrane
implementation of a novel functional eye-tracking biomarker for multiple sclerosis

Conditions: Clinically Isolated Syndrome; Relapsing Remitting Multiple Sclerosis

Summary: this study aims to develop and validate a sensitive and non-invasive eye-tracking software application. this study will obtain participant responses to brief cognitive tests designed to evaluate several key functions known to be affected by cis and rrms and non-invasive eye movement measurements in response to visually presented stimuli during specifically designed eye-tracking tests. the study data will be used to develop machine learning algorithms and validate a software application intended to identify which metrics-or combination thereof-can serve as reliable biomarker of cis and rrms disease progression and cognitive status.


Eligibility criteria:
inclusion criteria: * for all participants 1. able to provide informed consent 2. visual acuity of 20/100 in at least one eye (corrective glasses, contact lenses, surgery etc. are permitted) * for patients only 1. confirmed diagnosis of cis with abnormal mri or rrms 2. neurological condition is medically stable during the study visit exclusion criteria: * for all participants: 1. evidence or medical history of psychiatric issues, which are known to also affect movements and oculomotor control. 2. aged above 65 or less than 18 years of age. 3. presence of comorbid neurological conditions to avoid eye movement anomaly confounds (strabismus, cranial nerve palsy, stroke-causing hemianopsia). 4. diagnosis of macular edema or other pre-existing ocular conditions that would prevent from performing the eye movement assessments. * for healthy controls only: 1. evidence or history of significant neurological disorder (multiple sclerosis, parkinson's disease, amyotrophic lateral sclerosis, dementia)

Keywords: multiple sclerosis clinically isolated syndrome eye-tracking
memory training in aneurysmal subarachnoid hemorrhage patients

Conditions: Ruptured Aneurysm; Memory Deficits; Subarachnoid Hemorrhage

Summary: the study aim is to determine if periodic online cognitive exercises (lumosity) improve memory function in ruptured cerebral aneurysm patients with disabling baseline memory deficits within the first 24 months after rupture. half of the subjects will be randomized to use lumosity-designed online cognitive exercises and half will serve as an active control group performing online crossword puzzles.

in this prospective randomized, control clinical trial subjects have a self-reported disabling memory deficit within the first two years of their ruptured cerebral aneurysm. subjects will be recruited in the neurosurgery clinic setting, via email and phone screen, through social media and phone screen, or during a monthly support group for the patient population in question. during the screening interview the inclusion and exclusion criteria are assessed and informed consent is obtained if needed. those who qualify for the study will undergo a baseline assessment involving checklist for cognitive and emotional consequences following stroke (clce-24), working memory questionnaire, activity of daily living questionnaire, and a lumosity administered assessment. after baseline assessments randomization will occur stratified according to duration since sah \ 12 months, to either a treatment group, which will include online access to structure-oriented activities (lumosity), or an active control group(online crossword puzzles). subjects in the intervention group will undergo twenty training sessions over 10 weeks involving cognitive games selected from lumocity. games will be customized using an automated algorithm supplied by lumosity, to determine performance in the various targeted skills, which include: task switching, logical reasoning, quantitative reasoning, response inhibition, numerical calculation, working memory, face-name recall, selective attention, spatial recall, spatial orientations, planning, and divided attention. the recommended duration of interaction is 2 hours per week for 10 weeks. the control group uses a computerized crossword puzzle. the puzzle is offered in three different puzzle sizes, levels of complexity, and font sizes. these puzzles do not provide progressive challenge to the user by either increased speed, visual field size, number of distractors, or degree of difficulty of target stimulus differentiation.

Eligibility criteria:
inclusion criteria: * ruptured cerebral aneurysm-confirmed by study personnel within past year * age 18 and older * those with a modified rankin 0 or 1 * baseline memory problem affecting daily life * home computer or tablet with internet access exclusion criteria: * unable to read or speak english

Keywords: memory aneurysm deficits trouble forgetful ruptured subarachnoid hemorrhage
effects of back muscles endurance training in patients with chronic mechanical low back pain

Conditions: Mechanical Low Back Pain; Paraspinal Muscles; Muscle Stretching Exercises

Summary: low back pain is one the leading cause of disability and affecting many individuals. chronic low back pain is associated with restriction in daily physical activities that ultimately leads to disuse atrophy of muscles. the objective of the study is to find out the effects of back muscles endurance training on pain, disability, endurance and lumbar flexibility in patients with chronic mechanical low back pain.

low back pain is the leading worldwide cause of years lost to disability and its burden is growing alongside the increasing and ageing population. mechanical low back pain refers to back pain that arises intrinsically from the spine, intervertebral disks, or surrounding soft tissues. repetitive trauma and overuse are common causes of chronic mechanical low back pain, which is often secondary to workplace injury. most patients who experience activity-limiting low back pain go on to have recurrent episodes. low back pain is a common condition affecting many individuals at some point in their lives. chronic low back pain prevalence increases linearly from the third decade of life on, until the 60 years of age, being more prevalent in women.

Eligibility criteria:
inclusion criteria: * the ages between 20-45 years * both males and females * the presence of low back pain as a primary complaint * the onset of pain at least three months back exclusion criteria: * tumors, infection or inflammatory diseases affecting the spine * spinal or lower limb surgery * spinal fractures or structural deformities such as spinal stenosis, spondylolisthesis and spondylolysis * signs of nerve root compression * any contraindications for exercise therapy * patient with any spinal surgery, have respiratory or systemic diseases. * pregnant women. * sacroiliac joint dysfunction (determined by any three positives among distraction test, gaenslen's test, thigh thrust test, sacral thrust test, and compression test)
virtual reality glasses in palliative care

Conditions: Virtual Reality

Summary: developments in medicine and technology have led to an increase in life expectancy and an increase in the need for palliative care. palliative care aims to reduce or eliminate a life-threatening situation. the palliative care team cares for the patient and provides informal support to the patient. it should provide care that centers on caregivers (patient's relatives). relatives of patients who provide palliative care are responsible for their care as it increases, problems such as fatigue, hopelessness and anger may occur. problems experienced by caregivers of patients eliminating this problem and integrating it into care by providing psychosocial support is essential for the quality of care. caregivers health technologies can be used to support in our research, we found that virtual reality glasses were used in palliative care clinics. it is aimed to investigate the effect of patient relatives who care for inpatients on the psychological well-being and care burden. a randomized controlled research design was used in the study. the population of the research is a country in turkey between june and october 2023. the study consisted of patient relatives who provide care to patients in the palliative care clinic of the public hospital in the province. to research relatives of patients who met the participation criteria and agreed to participate (control group, n=22; experimental group, n=22) constituted the sample. data were collected from "caregiver introduction form", "psychological well-being scale", "caregiving burden scale" and "virtual reality glasses". it was collected using the "satisfaction form". before starting the research, a preliminary study was conducted with four patient relatives. of research in the implementation, firstly the preliminary application of the data collection tools was made. then, the experimental group was given weekly videos containing 360-degree images were watched using virtual reality glasses for 30 minutes for three days. in the control group no intervention was made. at the end of the research, the final application of the data collection tools was made. from research the data obtained was analyzed with the spss 22.0 package program.


Eligibility criteria:
inclusion criteria: * volunteering to participate in the research, * no vision, hearing or perception impairment that prevents communication, * not using glasses to wear vr glasses, * no psychiatric disease, * absence of complaints such as migraine, vertigo, active nausea, vomiting, headache, * not having someone to help you care for your patient. exclusion criteria: * wanting to leave the research.

Keywords: virtual reality nursing palliative care
nobori biolimus-eluting versus xience/promus everolimus-eluting stent trial

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to evaluate whether the newly-approved biolimus-eluting stent is not inferior to the everolimus-eluting stent in terms of the rate of target-lesion revascularization at 1-year and death or myocardial infarction at 3-year after stent implantation in the real world clinical practice.

everolimus-eluting stent is the most widely used coronary drug-eluting stent in japan. biolimus-eluting stent is a new coronary drug-eluting stent, which is going to be approved in 2011 by the japanese ministry of health, labor and welfare. it has been reported that biolimus-eluting stent had lower rate of target-lesion revascularization and stent thrombosis at 9 months as compared with paclitaxel-eluting stent. however, trial results comparing biolimus-eluting stent with everolimus-eluting stent are largely unknown. the purpose of this study is to evaluate whether the newly-approved biolimus-eluting stent is not inferior to the everolimus-eluting stent in terms of the rate of target-lesion revascularization at 1-year and death or myocardial infarction at 3-year after stent implantation in the real world clinical practice. the design of this study is all-comer design enrolling patients scheduled for percutaneous coronary intervention using drug-eluting stents without any exclusion criteria.

Eligibility criteria:
inclusion criteria: * patients scheduled for percutaneous coronary intervention using drug-eluting stents

Keywords: coronary stent
comparison of two phacoemulsification-methods: hf easytip 2.2mm vs. hf easytip 2.8mm

Conditions: Cataracts

Summary: the aim of this study was to compare the intraoperative efficiency, safety and postoperative outcomes of cataract surgery with two different "high-fluidic" settings.


Eligibility criteria:
inclusion criteria: * bilateral age-related cataract * good overall physical constitution * locs 2-5 exclusion criteria: * previous intraocular surgery or ocular trauma * previous corneal pathology * previous endothelial cell count \<1200 * glaucoma * uveitis * pex * diabetic retinopathy and any other severe retinal pathology that would make a postoperative visual acuity of 20/40 (decimal equivalent = 0.5) or better unlikely * intraocular complication like posterior capsular * postoperative comlpications (e.g. postoperative uveitis)

Keywords: efficacy and safety
physical activity and obesity

Conditions: Obesity; Prediabetic State; Sedentary Lifestyle

Summary: the purpose of the study is to see if a twelve-week exercise intervention in overweight or obese subjects with pre-diabetes or early disease course type 2 diabetes can lead to improved skeletal muscle capillary blood flow by improving substances that dilate blood vessels and result in improved insulin sensitivity.


Eligibility criteria:
inclusion criteria: 1. males and females ages 30-60 years of age 2. overweight and obese (28\< bmi \<45) 3. confirmed pre-diabetic (5.7≤ hba1c \< 6.5) 4. type 2 dm, diagnosis 2 years or less, on no medications or metformin only, hba1c ≤ 6.7 exclusion criteria: 1. stage 3 chronic kidney disease (glomerular filtration rate \[gfr\] \< 60) 2. obstructive coronary artery disease 3. congestive heart failure (ejection fraction \< 55%) 4. peripheral vascular disease, 5. degenerative joint disease, musculoskeletal disease, or peripheral vascular disease that limits ability to exercise 6. know hypersensitivity to definity® ultrasound contrast agent 7. intra-cardiac or pulmonary shunt 8. the use of antithrombotic agents or a severe bleeding diathesis due to risk of bleeding with intravenous and arterial line placement 9. physical activity greater than three hours per week 10. pregnancy

Keywords: obesity prediabetic state sedentary lifestyle insulin resistance endothelium eicosanoids nitric oxide regional blood flow
rehabilitation for survivors of out-of-hospital cardiac arrest

Conditions: Cardiac Arrest; Heart Arrest; Cardiopulmonary Resuscitation; Return to Work; Return-to-work; Rehabilitation; Recovery of Function; Cardiac Rehabilitation

Summary: this study is a parallel group multicentre investigator-initiated clinical randomised controlled superiority trial that will include a total of 214 survivors of ohca. participants will to be randomized with a 1:1 allocation ratio to either a intervention consisting of a comprehensive initiated tailored rehabilitation intervention focusing on supporting rtw plus usual care compared to usual care alone.

the rock trial is a two-arm multicentre investigator-initiated clinical randomised controlled superiority trial evaluating the effectiveness of a comprehensive individually tailored rehabilitation intervention focusing on supporting labour marked participation of survivors of out-of-hospital cardiac arrest compared to usual care, with primary endpoint measured after 12 months follow-up. the overall aim of the rock trial is to evaluate the effectiveness of a comprehensive individually tailored multidisciplinary rehabilitation intervention for survivors of ohca on rtw compared to usual care. the investigators hypothesize that the intervention will result in a higher-level labour marked attachment one year after hospital discharge in addition to increased health-related quality of life. a full statistical analysis plan describing all details have been developed. in short, data from the national register on social transfer payments (dream database) will form the basis for the primary outcome. the primary outcome is labour market participation, defined as the proportion of employment vs. on social transfer payment, and the primary end point will be collected 12 months after hospital discharge.

Eligibility criteria:
inclusion criteria: * all adult survivors with first time out-of-hospital cardiac arrest * discharged from the hospitals will be assessed eligible for inclusion exclusion criteria: * survivors who prior to the cardiac arrest were not part of the labour force with at least two years until they are qualified to receive retirement state pensions * patients that cannot understand and fulfil the study surveys (in danish) * patients with short witnessed cardiac arrests with return of spontaneous circulation estimated less than 4 minutes and immediate awakening without icu treatment

Keywords: labour marked cardiac arrest heart arrest cardiopulmonary resuscitation return to work return-to-work back to work rehabilitation recovery of function cardiac rehabilitation