Kornimate/medical-research-clean huggingface dataset:
multiclear treatment for striae distensae - a pilot study

Conditions: Striae Distensae

Summary: striae distensae is a common skin condition that rarely causes significant medical problems. however, it often results in a considerable amount of distress to those with the condition. various modalities of treatments have been used for striae distensae but few have led to satisfactory results. more recently, newer techniques such as pulsed dye laser and radiofrequency devices have been used with modest results. there is still, however, paucity of data using light therapy for the treatment of this condition. blue light therapy using the multiclear device has been used successfully in the treatment of acne. in contrast, there is little data to suggest its use in the management of striae distensae. we aim to study the effects of blue light on the treatment of striae distensae and whether this can be used safely to manage this condition.

patients will receive twice weekly blue light treatment with the multiclear device. the first treatment dose will be 75mj/cm2 ( minimum effective dose;med) for all patients. if no erythema develops, the subsequent treatment dose can be increased by 0.5 med. if mild to moderate erythema develops, the same dose (i.e. 1 med) will be used.if severe erythema/ blisters develop, treatment will be stopped and the patient wil be invited one week later and treatment will be offered at 50% of the last dose. during the first consultation, patients will be assessed for the presence of striae distensae (sd). duration and previous treatments of sd will be recorded. the width of the widest striae and the length of the longest straie will be measured at baseline and after 2 months of treatment. photographs will be taken at baseline and post treatment. these will be evaluated by dermatologists who will be blinded (i.e. details of which photographs are pre or post treatment will not be given). subjective scores will be used (very good to excellent; \>75%, good; 51-75%, moderate; 26-50%, minimal to no improvement; \<25%) participants will also be given a feedback form to rate any improvements noted and any side effects experienced.

Eligibility criteria:
inclusion criteria: 1. both male and female subjects 2. patients above 21 years 3. patients who are able to attend follow up regularly exclusion criteria: 1. patients with other co-existing dermatoses 2. patients with epilepsy/ who are pregnant 3. patients with previous intolerable treatment to blue light 4. patients treated with blue light within the last six months

Keywords: striae distensiae
prevention of type 2 diabetes mellitus by changes in diet

Conditions: Prediabetes

Summary: investigators evaluated the efficacy of two types of diet with different macronutrients, on prevention or delaying the onset of type 2 diabetes in subjects with either impaired fasting glucose (ifg) or impaired glucose tolerance (igt). 322 subjects with prediabetes were randomly assigned to high monounsaturated fat diet (n=107), high carbohydrate diet (n=106) or control group (n=109) and followed for 2 years. for calculating daily energy requirement in subjects with bmi≥25 kg/m2 the weight was adjusted with the use of 110 percent of the ideal body weight with no attempt for losing body weight. control group were encouraged to follow the food guide pyramid and reduce their fat intake to less than 30% of energy consumed and saturated fat to less than 10 percent of total energy. the primary outcome variable was incidence of type 2 diabetes mellitus, diagnosed by the latest american diabetic association criteria.

322 participants were randomized and stratified into a control group and two study groups according to sex, age, body mass index (bmi), ifg and igt or both. baseline assessments were anthropometric measurements, food diary and laboratory exams. anthropometric measurements were repeated annually. blood sample tests measured fasting blood glucose, glucose two hours after ingestion of 75 g glucose, high density lipoprotein (hdl), low density lipoprotein (ldl) and triglyceride (tg), which were analyzed in the laboratory of the only university hospital in the city. the same assessments were repeated annually (at 12 and 24 months) in all groups. daily energy requirement was calculated by multiplying 30-35 kcal per kg body weight for each participant. for patients with bmi ≥25 kg/m2, the weight was adjusted with use of 110 percent of the ideal body weight. diet in hcd group was 15% from protein, 30% from fat (10% mufa, 10% pufa, 10% sfa) and 55% from carbohydrate. diet in hmd group was 15% from protein, 45% from fat (25% mufa, 10% pufa, 10% sfa) and 40% from carbohydrate. source of mufa in this group was olive oil. in the intervention groups diet regimen was written for each participant by a registered dietitian. group three or the control group was encouraged to follow the food guide pyramid and reduce their fat intake to less than 30 percent of energy consumption and saturated fat to less than 10 percent of total energy.

Eligibility criteria:
inclusion criteria: adults over 20 years exclusion criteria: diet therapy; severe physical activity; accompanying diseases such as cancer which reduce their life expectancy; receiving thiazide diuretics; receiving systemic ß blockers; receiving glucocorticoids; receiving nicotinic acid; receiving weight lowering drugs
a study of epoetin beta (neorecormon) in anemic participants with diabetes and chronic renal failure who are not on dialysis

Conditions: Anemia

Summary: this study will evaluate the effect of epoetin beta (neorecormon) on correction of anemia and quality of life in participants with diabetes and chronic renal failure and who are not receiving dialysis.


Eligibility criteria:
inclusion criteria: * type 1 or 2 diabetes * chronic renal failure (stage 2 to stage 5) defined by glomerular filtration rate (gfr) less than (\<) 90 milliliter per minute per 1.73 square meter (ml/min/1.73 m\^2) * anemia related to chronic kidney disease and requiring treatment with erythropoiesis-stimulating agent (esa) (2 values of hemoglobin less than or equal to 11 gram per deciliter \[g/dl\] during the 3 months prior to inclusion), and hemoglobin greater than 8 g/dl exclusion criteria: * anemia due to a non-renal cause * poorly controlled hypertension * treatment with an erythropoiesis stimulating agent (esa) within 3 months prior to the study * planned dialysis in next 3 months or organ transplant * history of cancer except for basal cell cancer and cervical cancer in situ
russian severe asthma registry

Conditions: Severe Asthma

Summary: the russian severe asthma registry is a russian initiative to collect anonymous long-term evidence for patients with severe asthma in russia

the russian severe asthma registry is a russian initiative to collect anonymous long-term evidence for patients with severe asthma in russia. the rsar initiative is realized under the efforts of the interregional public organization "russian respiratory society" and llc "rsmi" with the sponsorship of "astrazeneca pharmaceuticals" llc. the developed rsar electronic database is a russian software product that meets the current requirements of the russian legislation in the field of working with personal data and the implementation of similar observational studies. participating researchers also agree to grant access and share anonymous data at the patient level as part of the work to implement the rsar initiative. participants will provide high-quality data for the development of data sets for research, approved by the russian respiratory society (rpo), which has priority in owning and implementation in scientific field of the gained data. based on ethical, legal and regulatory authorizations, anonymous data will be collected in the central database (cdb) on respiratory diseases (referred to here as the rsar database) to create sets of important data and the necessary analysis. cdb is part of the software "medical online platform rosmed.info".

Eligibility criteria:
inclusion criteria: * patients aged 12 years or older. * patients with confirmed diagnosis of severe asthma. * patients receiving treatment according to gina step 5 or uncontrolled for 4 step. uncontrolled patients are defined as having symptoms of severe asthma or frequent exacerbations . * signed informed consent. exclusion criteria: * patients currently participating in clinical trials at the time of enrolment * intermittent, mild, moderate ba, before verification of the diagnosis. * copd. * diseases of the respiratory system, such as tuberculosis, sarcoidosis, ipf, lung cancer. * vasculitis, systemic connective tissue diseases. * neoplasm. * written refusal of the patient to participate in the study after signing an informed consent.

Keywords: severe asthma
comparative effects of nerve gliding exercises and conventional grip strength exercises in batters.

Conditions: Nerve Compression

Summary: cricket is transformed over the years and dynamic of batting has changed. gone are the days, when batters used to play the game with defensive mindset. maintaining higher striker rate and arsenal of power hitting is the epitome of stroke play in limited overs cricket.this study will compare the effects of the nerve gliding exercises and conventional grip strength exercises on handgrip strength, range of motion and performance of cricket batters. it will be a randomized clinical trial where non-probability convenience sampling will be used to recruit participants aged 18 to 35 years from various cricket academies in lahore.

cricket is transformed over the years and dynamic of batting has changed. gone are the days, when batters used to play the game with defensive mindset. maintaining higher striker rate and arsenal of power hitting is the epitome of stroke play in limited overs cricket. after modernization of the game, several exercises are adapted to enhance the hitting capability of batsmen with conventional grip strength training but the effectiveness of nerve gliding exercises on handgrip strength is not utilized in cricketing population effectively as compared to tennis and squash players, where it improves the efficiency of wrist mobility in efficient stroke play. this study will compare the effects of the nerve gliding exercises and conventional grip strength exercises on handgrip strength, range of motion and performance of cricket batters. it will be a randomized clinical trial where non-probability convenience sampling will be used to recruit participants aged 18 to 35 years from various cricket academies in lahore. participants will be randomized through lottery method and allocated into two groups. group a (n=20) participants will receive nerve gliding exercises intervention, while group b (n=20) will receive conventional grip strength exercises intervention. the adjustable hand dynamometer for grip strength, goniometer for range of motion while batting tee test for performance will be outcome measure tools. data will be analyzed by spss version 26. the normality of the data will be conducted through the shapiro-wilk test; for between-group analysis, an independent t-test or mann-whitney will be conducted. similarly, a paired t-test or wilcoxon rank test will be conducted for within-group analysis.

Eligibility criteria:
inclusion criteria: * age between 18 to 35 years * batsmen * doing net practices more than 4 days per week for at least 3 months. * right hand grip strength (men) 42.9-46.4, left hand grip strength (men) 42.042.2. exclusion criteria: * non-athletic population * upper extremity peripheral neuropathies. * tennis/golfer epicondylitis. cervical disc herniation. * overuse injuries of the shoulder joint that may affect handgrip strength. * having any neurological or orthopaedical problem related to upper extremity.

Keywords: nerve gliding exercises grip strength range of motion hand exercise program
effects of aerobic and strength exercice on nociplastic pain in temporomandibular disorders

Conditions: Temporomandibular Disorders (TMD); Nociplastic Pain; Aerobic Exercise; Strengthening Exercises; Myofascial Pain Dysfunction Syndrome, Temporomandibular Joint

Summary: chronic temporomandibular disorders are common in the general population. nociplastic pain seems to be present in this pathology, with an hypersensitivity to touch, pressure and movement observed in both local and remote areas, as weel as comorbidities such as fatigue, sleep disturbance, difficulty to focus attention and memory disturbance. the best evidence-based treatment of temporomandibular disorders consists in combining education, manual therapy and therapeutic exercise in both temporomandibular and cervical regions. aerobic and strength exercises showed to be effective in subjects with chronic pain and nociplastic pain, by inducing an hypoalgesic effect. however, there isn\&#39;t investigation about the effects of theses types of exercise in subjects with temporomandibular disorders and nociplastic pain. thus, the aim of the study is to determine if adding aerobic or strength exercise to an effective physical therapy programme is more effective than physical therapy alone to improve nociplastic pain in subjects with temporomandibular disorders.

introduction: temporomandibular disorders used to improve with education manual therapy and therapeutic exercise. however, despite the evidence oh nociplastic pain in these patients, the treatments remain local. as aerobic and strength exercice have hypoalgesic effect in chronic musculoskeletal pain, we aim to study the effects combined with a common physical therapy programme on nociplastic pain in patients with temporomandibular disorders. main objective: determine if aerobic exercice and strength exercice combined with physical therapy are more effective than physical therapy alone to improve local and remote pressure pain threshold (temporals, masseters, sternocledomastoids, upper trapezius, handgrip, quadriceps and gastrocnemius), in subjects with temporomandibular disorders and nociplastic pain. material and methodos:

Eligibility criteria:
inclusion criteria: * diagnosis of a myogenic temporomandibular disorder (dc/tmd) by an odontologist. * chronic pain (\&gt;3months) * nociplastic pain * positive flexion rotation test * be physically able to realize aerobic and strength exercise (functional movement test) exclusion criteria: * history of trauma, tmj or cervical fracture the past three months * history of tmj or cervical surgery * systemic, rheumatic, metabolic, neurologic, psychiatric, pulmonary diseases or neoplastic malignant * history of cardiovascular diseases which contraindicate aerobic exercise * current orthodontic treatment, splints for bruxism * drug addiction, alcoholism * pregnancy * use of analgesic medication less than 48 hours before each data collection * physical therapy treatment during the past three month
message communicating latest data on covid-19 transmission in patient's area

Conditions: COVID-19

Summary: this experiment is part of a megastudy with a total of ten experimental conditions and a holdout control condition to which patients will be randomly assigned. the focal comparison in this experiment is between a message encouraging vaccination by communicating to patients that they live in an area with significant covid transmission and a control message telling patients that an updated covid booster vaccine is waiting for them.


Eligibility criteria:
exclusion criteria: 1. the patient unsubscribed from texts before the send date and time of the patient's sms/mms message 2. the patient received a bivalent covid booster before the send date and time of the patient's sms/mms message.

Keywords: covid-19 behavioral science interventions vaccination promotion
a prospective study comparing the accuracy of olympus lucera spectrum technology vs olympus lucera elite technology in the in vivo diagnosis of barrett's oesophagus and colorectal polyps: the elite study

Conditions: Barrett Esophagus; Polyps

Summary: barrett's oesophagus is a condition where the lining of the oesophagus (gullet) wall changes. people with barrett's oesophagus are at risk of developing oesophageal cancer but can have regular checkups to detect changes before they progress to cancer. every two years patients with barrett's are offered examination by passing a fibreoptic tube into the oesophagus (gastroscopy) to remove small tissue samples (biopsies), which are examined in the laboratory to check for changes. bowel cancer is the third most common cancer in the uk, and the second leading cause of cancer deaths. prevention and early detection are the most effective strategies of dealing with bowel cancer. most cancers develop from benign polyps (growths) in the bowel. polyps are common and have the potential of developing into cancer over the course of many years. patients with a prior diagnosis of barrett's oesophagus and colonic polyps undergo regular endoscopic examinations known as surveillance endoscopies. this is done to detect changes in the cells of barrett's oesophagus or further polyps. current practice is to capture recorded videos of barrett's surveillance examinations and still images of polyps prior to their removal. endoscope technology continues to advance. these newly developed technologies are marketed to have claims of superiority in performance over preceding generations often without the back up of scientific data but at a significant financial cost. the aim of this study is to use endoscopic images and videos recorded as part of routine clinical practice to compare the current version of olympus endoscopes with the new version launched by the company.


Eligibility criteria:
inclusion criteria: * patients attending for barrett's surveillance or * patients attending for colonic polyp surveillance or screening * patients are willing and able to give informed consent. exclusion criteria: * polyp syndromes (eg fap or lynch syndrome) * known history of ibd
safety of arcblate mrghifu in patients with painful bone metastases: an extension study

Conditions: Bone Metastases

Summary: an extension study to evaluate the safety of arcblate mrghifu in patients with painful bone metastases

pain palliation of bone metastasis through localized denervation by thermal ablation.

Eligibility criteria:
inclusion criteria: 1. male or female, who randomized into sham control group and withdrew from ctp-bm-22-01 study (i.e. main study) due to lack of efficacy. 2. completed 14-day evaluation in main study. 3. will provide completed and signed written informed consents. exclusion criteria: 1. pregnant women. 2. subjects who do not meet any of the inclusion criteria in ctp-bm-22-01 study (i.e. main study) after re-evaluation. 3. determined by the investigator to be not suitable for the conduct of the study for any other reasons.
combined vitrectomy and triamcinolone in macular edema secondary to branch retinal vein occlusion (brvo)

Conditions: Branch Retinal Vein Occlusion; Macular Edema

Summary: the purpose of this study is to determine whether pars plana vitrectomy in combination with triamcinolone acetate is effective in the treatment of macular edema due to branch retinal vein occlusion.


Eligibility criteria:
inclusion criteria: * macular edema secondary to brvo * best corrected visual acuity of ≤ 20/40 on etdrs chart * duration no shorter than 3 months * duration no longer than 12 months exclusion criteria: * proliferations in study eye * blod in vitreous cavity * previous fundus laser treatment * brvo with over 180˚ of ischemia on fa * age under 18 * other eye condition which contribute to relevant loss of visual acuity

Keywords: branch retinal vein occlusion brvo macular edema triamcinolone vitrectomy
prasugrel monotherapy following primary percutaneous coronary intervention for st-elevation myocardial infarction

Conditions: ST-segment Elevation Myocardial Infarction (STEMI)

Summary: the aim of this study is to evaluate the safety of prasugrel monotherapy without aspirin versus 12-month dual antiplatelet therapy (dapt) in patients with stemi using platinum-chrome everolimus-eluting stent (ptcr-ees: synergytm).

in the stopdapt-2 acs trial (nct03462498), ischemic events (especially myocardial infarction) was significantly increased with 1-month dapt followed by clopidogrel monotherapy, as compared to 12-month dapt in patients with acute coronary syndrome (acs). this was potentially attributable to clopidogrel, instead of prasugrel, which is more potent and has less individual difference in efficacy. on the other hand, previous studies including the stopdapt-2 acs that evaluated the safety and efficacy of monotherapy with a p2y12 inhibitor without aspirin consistently and significantly reduced the risk of bleeding, compared with standard dapt. consequently, there has been growing necessity to establish the safety with p2y12 inhibitor monotherapy in terms of major adverse cardiovascular events. therefore, we have planned to evaluate the non-inferiority of p2y12 inhibitor monotherapy with prasugrel versus standard 12-month dapt with prasugrel and aspirin in terms of the incidence of major cardiovascular events at 12 months after primary pci in patients with stemi using platinum-chromium everolimus eluting stent (ptcr-ees; synergytm).

Eligibility criteria:
inclusion criteria: * patients scheduled for primary pci with everolimus-eluting stent (ptcr-ees, synergytm) * stemi patients * patients who can continue dual antiplatelet therapy with aspirin and a p2y12 inhibitor for 12 months exclusion criteria: * patients taking anticoagulants * patients under 18 years old * patients with less than 1 year prognosis * patients participating in other intervention studies

Keywords: acute coronary syndrome dual antiplatelet therapy drug eluting stent percutaneous coronary intervention st-elevation myocardial infarction
slow coronary artery flow: influence on morbidity and mortality

Conditions: Coronary Disease

Summary: to compare patients with slow coronary artery flow to patients with normal flow and to determine whether there is a difference in their future incidence of heart disease.


Eligibility criteria:
inclusion criteria: * patients who underwent coronary angiography exclusion criteria: * patients with coronary occulsion above 50% * patients with severe valve disorder

Keywords: coronary slow flow phenomenon coronary angiography acute coronary syndrome chest pain unstable angina
prospective evaluation of idiopathic pancreatitis: role of endoscopic ultrasonography

Conditions: Gallbladder Disease; Pancreatitis

Summary: the purpose of the study is to determine the best evaluation for patients with idiopathic (unexplained) pancreatitis.

the study evaluates the role of endoscopic ultrasonography, given that the minimally invasive procedures can diagnosis gallbladder disease as well as pancreatitis abnormalities.

Eligibility criteria:
inclusion criteria: * all patients referred to the principal investigator for unexplained pancreatitis will be enrolled. exclusion criteria: * there are no gender nor racial exclusion.

Keywords: endoscopic ultrasonography pancreatitis eus