Kornimate/medical-research-clean huggingface dataset:
radial extracorporeal shock wave therapy on chronic low back pain: a prospective controlled study

Conditions: Low Back Pain

Summary: the aim of this prospective study is to explore the pain-alleviating effect of low-energy extracorporeal shock wave therapy(eswt) in patients with chronic low back pain.

26 patients who suffered from persistent symptoms for more than 3 months are going to be treated with dolorclast radial extracorporeal shock wave(ems, swiss). patients are assigned to two groups according to the exist of specific pain spot. group i(have specific pain spot) received a total of 2000 impulses of 2.5 bar; group ii(controls, no specific pain spot) 4000 impulses of 2.5 bar. patients is going to be treated once. the efficacy of therapy is going to be evaluated by vas scale before and after the treatment.

Eligibility criteria:
inclusion criteria: * symptom of low back pain during last 4 weeks * low back pain history for more than 3 months exclusion criteria: * have lower limbs radiating pain beyond knee joints * spinal tumorous or infectious disease, fracture, ankylosing spondylitis, cauda equina syndrome or other severe spinal diseases * spinal surgical history * severe heart, lung, liver, kidney disease or high blood pressure * with cardiac pacemaker * coagulopathy or thrombosis * have esw therapy or pharmaceutical treatment for low back pain during last 1 months * mental illnesses or none cooperation * pregnancy

Keywords: low back pain extracorporeal shock wave therapy trigger points
sngception and pain in spine enhanced recovery after surgery (eras) pathways

Conditions: Pain Postoperative

Summary: enhanced recovery after surgery (eras) is a recognized, evidence-based and patient-centered clinical pathway that has an array of benefits. minimally invasive techniques, a cyclopedic pain management plan and precise administration of anesthetics, which will render patients a rapid and comfortable recovery if executed correctly, followed by early mobilization and discharge. pain management practice is traveling through a paradigm shift as opioid crises arise in the western countries. opioid-based pain control is being disarmed and replaced by multimodal analgesia (mma) and becoming the mainstay strategy. opioids are increasingly being reserved as rescue medications. mma target different parts of the nociceptive pathway, preventing its wind-up during surgery. decreased firing of the nociceptive neurons may be linked to lower postoperative pain scores or even the suppressing chronic pain incidence. in our eras pathway, we implement erector spinae plane block (espb) as the main analgesic firepower. as postoperative pain decreases, an observed rising complaint is "sng", or soreness, in native taiwanese in our eras spine patients. it is very different from the nociceptive "pain" we are familiar with. patients avoid movements if it causes pain, but they tend to stretch or adjust postures if sngception dominates. the term "sngception" has been proposed in 2018 by taiwanese scholars. it is believed to be a sense of acidosis, possibly within the muscles. acidosis and associated pain are well documented, such as in muscle aches from exercise, cancer or diabetic ketoacidosis. the underlying mechanism is yet to be established but does not entirely overlap with nociception. there are numerous similarities of sngception in our patients and sngception: 1. a sensation different from nociception, 2. usual painkillers are ineffective, suggesting an alternative route of transmission, 3. relieved by movement, 4. inflammation and acidosis in the vicinity of surgical wound. in this study, we intended to characterize sngception by observing various perioperative factors, as well as the short- and long- term outcomes they bring. this will be done through a detailed sngception and pain trajectory analysis. only when we know the main causative factor(s), we can design treatment plans toward guarding against sngception. this further improves the quality of postoperative recovery and safety as less opioids may be required as rescue medications.


Eligibility criteria:
inclusion criteria: 1. patients undergoing routine eras protocol for spine surgeries 2. american society of anesthesiologists physical status (asa-ps) i\~iii exclusion criteria: 1. communication issues that preclude proper preoperative counselling for eras and study design. 2. active alcohol or drug addiction. 3. pregnancy 4. allergy to main anesthetics that preclude the use of routine eras anesthesia management. 5. patient refusal to participate in study. 6. emergent operations.

Keywords: enhanced recovery eras spine surgery pain sngception sng
platelet rich plasma combined with platelet rich fibrin in management of temporomandibular joint osteoarthritis

Conditions: Osteoarthritis

Summary: studying effectiveness of prp with prf comparing with prp or prf for mangement of tmj osteoarthritis as result in pain and mandibular movement in adult pt

45 pt assigned for the study , divided in to three gruops to comparing new combination of prp with prf in management of tmj oa

Eligibility criteria:
inclusion criteria: adult pt with oa exclusion criteria: medicaly compromised
usefulness of rehabilitation in patients with cervical imbalance

Conditions: Rehabilitation; Cervical Vertigo

Summary: using the data obtained in a study carried out at the hospital of alcañiz (teruel, spain) between february and july 2019, with a stabilometric platform and with movement sensors, the investigators want to demonstrate that the rehabilitation works in those patients with vertigo or dizziness of cervical origin. for this, the data obtained from that sample, which was of 67 patients, will be analyzed in a pre-post rehabilitation treatment study, objectifying whether the patients improved or not, both in terms of imbalance and cervical pain, if any.

using the data obtained in a study carried out at the hospital of alcañiz (teruel, spain) between february and july 2019, with a stabilometric platform and with movement sensors, the investigators want to demonstrate that the rehabilitation works in those patients with vertigo or dizziness of cervical origin. for this, the data obtained from that sample, which was of 67 patients, will be analyzed in a pre-post rehabilitation treatment study, objectifying whether the patients improved or not, both in terms of imbalance and cervical pain, if any. the 67 patients attended the rehabilitation consultation where, after taking the anamnesis, they began to perform balance tests with a stabilometric platform and those patients with associated neck pain, with cervical motion sensors. treatment with conventional physiotherapy, electrotherapy or exercises at home was prescribed as appropriate to each one. 3 months later, the patients were examined again in consultation, using a new anamnesis, the platform and the sensors. with the data obtained in said field work, carried out in 2019, the present study aims to analyze the usefulness of rehabilitation treatment in vertigo.

Eligibility criteria:
inclusion criteria: * present vertigo of vestibular, neurological or cervical cause. * the last episode of vertigo occurred less than a year ago. exclusion criteria: * present acute musculoskeletal pathology in the lower limbs or lumbar spine. * present some lower limb amputation. * present unresolved visual pathology. * being active with anticancer treatment.
svc occlusion in subjects with acute decompensated heart failure

Conditions: Acute Decompensated Heart Failure; Acute Heart Failure; Congestive Heart Failure; Heart Diseases

Summary: safety and performance evaluation of the precardia system for patients with adhf.

the objective of this early feasibility study is to evaluate the safety and performance of the precardia system for superior vena caval (svc) intermittent mechanical occlusion as a therapeutic approach in significantly congested subjects with acute decompensated heart failure (adhf), who are not diuresing adequately.

Eligibility criteria:
inclusion criteria: * nyha class iii-iv heart failure * subjects with inadequate diuresis * stage c-d systolic heart failure exclusion criteria: * active myocardial ischemia or acute coronary syndrome (acs) * severe aortic or mitral valve insufficiency * severe peripheral vascular disease
tele-rehabilitation home exercise program for ambulatory adults with cerebral palsy

Conditions: Cerebral Palsy

Summary: this study aims to determine if a tele-rehabilitation home exercise program is feasible to promote adherence to a fitness and mobility exercise program in ambulatory adults with cerebral palsy (gmfcs i, ii, iii) aged 21- 60 year old, and second, to determine if a tele-health exercise program improves fitness and functional mobility for participants.

cerebral palsy (cp) is a non-progressive neurologic condition caused by a brain lesion(s) that occurs in the prenatal, perinatal or early postnatal period. ambulatory adults with cp are at risk for gait deterioration and increased sedentary lifestyles due to their diagnosis, associated conditions and the impact of aging. adults with cp often have limited access to physical therapy (pt) and community-based programs to sustain ambulation, reduce pain, prevent falls risk and increase fitness and physical activity. this tele-rehabilitation home exercise program (trhexp) is a prospective cohort study participants in this feasibility study will engage in 150 minutes of exercise per week (30 min/day for 5 days/week) for 8 weeks and will have weekly virtual exercise coaching sessions with a trained project team member.

Eligibility criteria:
inclusion criteria: * primary diagnosis: spastic cerebral palsy (unilateral or bilateral) * gross motor function classification system (gmfcs) level i to iii * no orthopedic surgery in past year * no botox in past 3 months * able to follow directions \& attend for 20-30 minutes * able to stand independently up to 1 minutes with or without an assistive device * able to walk independently up to 2 minutes with or without an assistive device * must have a laptop, tablet or smart phone to do the program exclusion criteria: * visual, cognitive or attentional deficit that makes it too difficult to participate * no technology to participate in zoom tele-rehabilitation sessions * medical contraindications to participate in an exercise program (e.g., uncontrolled hypertension, diabetes, syncope, uncontrolled seizures)

Keywords: exercise telehealth rehabilitation
study on adjuvant chemotherapy after total two-field lymph node dissection of thoracic esophageal squamous cell carcinoma

Conditions: Thoracic Esophageal Squamous Cell Carcinoma

Summary: patients with thoracic esophageal squamous cell carcinoma after total two-field lymph node dissection were randomized into the adjuvant chemotherapy group or the postoperative observation group

patients with t≥3 or n≥1 thoracic esophageal squamous cell carcinoma after total two-field lymph node dissection were randomly enrolled into the experimental group for adjuvant chemotherapy or the controlled group for postoperative observation. the experimental group received 4-course chemotherapy of docetaxel combined with nedaplatin, and to observe the 3-year progression free survival (dfs) and 5-year overall survival (os) in two groups.

Eligibility criteria:
inclusion criteria: 1. patients with esophageal squamous cell carcinoma who received radical surgical resection and total two-field lymph node dissection did not receive neoadjuvant therapy before surgery, and didn't suffer serious complications after surgery. 2. t≥3 or n≥1, and more than 15 lymph nodes were dissected. 3. age ≥18 years and ≤75 years. 4. eastern cooperative oncology group (ecog) performance status score of 0 or 1. 5. adequate hematological function: absolute neutrophil count (anc) ≥ 1.5×109/l, and blood platelet count (plt) ≥ 1.5×109/l, and hemoglobin ≥ 9g/dl. 6. adequate hepatic function: total bilirubin ≤1.5 times the upper limit of normal (uln), aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase ≤2.5 × uln. 7. adequate renal function: serum creatinine ≤1.5 × uln and creatinine clearance ≥50 ml/min. 8. subjects could understand and comply with study and follow-up procedures, and voluntarily signed written informed consent exclusion criteria: 1. suffering from previous primary malignancy or co-existing serious illness of other organs, which will affect the judgment of the end point of this study. 2. serious postoperative complications that will affect progress of chemotherapy. 3. patients with chemotherapy contraindications. 4. women who are pregnant or breast-feeding or who are planning for pregnancy. 5. unable to complete the follow-up as planned. 6. without informed consent due to psychological, family, social and other factors.

Keywords: adjuvant chemotherapy
adherence to european society of cardiology guideline-directed medical therapies for patients with chronic heart failure in france

Conditions: Heart Failure; Heart Failure With Preserved Ejection Fraction (HFPEF); Heart Failure With Reduced Ejection Fraction; Remote Monitoring; Care Management, Patient

Summary: the goal of this observational study was to evaluate trends and determinants of sglt2 inhibitor (sglt2i) prescriptions in heart failure patients from 2021 to 2024, particularly in relation to lvef subgroups and evolving scientific evidence (emperor-preserved, deliver, 2023 guidelines). participant population were adults with heart failure using the satelia®cardio web application to remotely monitor their condition. the main questions it aims to answer are: * to compare the prescription of treatments (including doses, and distribution of patients according to various therapeutic classes recommend for heart failure) with esc recommendations to see to what extent gdmts are adhered to. * to quantify the association between the presence of treatments and the risk of alerts/hospitalizations and overall death and as a function of lvef using telemonitoring. * to evaluate the adherence across patient profiles and cardiologist practices (outpatient vs. hospital-based). participants will complete follow-up, quality-of-life and patient support questionnaires and provide data regarding their treatments on the web application.

a retrospective, multicenter descriptive study was conducted in france from january 1, 2021 to december 31, 2024. the remote-hf study included 17,551 patients enrolled in remote monitoring program for heart failure (hf) management. we described and analyzed the implementation of esc guidelines in patients monitored remotely with a web application named satelia®cardio (np medical). key clinical parameters such as age, gender, nyha class, lvef, and hf etiology were analyzed. prescribed therapies including acei/arb/arnis, beta-blockers, mras, and sglt2 inhibitors, were compared against the european society of cardiology (esc) guideline-directed medical therapies (gdmts). adherence was evaluated across patient profiles and cardiologist practices (outpatient vs. hospital-based) in france.

Eligibility criteria:
inclusion criteria: * registered to use satelia®cardio to remotely monitor their condition * patients diagnosed with heart failure whatever the aetiology: especially patients who undergone: hospitalization within the previous 12 months, or patients with nyha class ii or more, and bnp \> 100 pg/ml or nt-probnp \> 1000 pg/ml. exclusion criteria: * people aged under 18 years old * pregnant women * physical or psychological impossibility for the patient or carer to use the digital medical device according to the judgment of the doctor wishing to include the patient in the remote medical monitoring project.

Keywords: heart failure guideline-directed medical therapy gdmt remote monitoring
conventional photodynamic therapy vs. painless photodynamic therapy for actinic keratosis

Conditions: Actinic Keratosis

Summary: this study is being done to compare a new, continuous illumination and short incubation time regimen of aminolevulinic acid photodynamic therapy#ala-pdt) to a conventional regimen for treatment of actinic keratosis. the hypothesis is that the continuous illumination approach will be less or even no painful, but equally efficacious, as the old regimen.

this study is being done to compare a new, continuous illumination and short incubation time regimen of aminolevulinic acid photodynamic therapy#painless-pdt) to a conventional regimen for treatment of actinic keratosis. the hypothesis is that the continuous illumination approach will be less or even no painful, but equally efficacious, as the old regimen.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosed with ak (olsen classification grade i, ii, iii), aged \> 18 years (because no dosing or adverse event data are currently available on the use of topical aminolevulinic acid in patients \<18 years of age, children are excluded from this study); 2. all patients are unfit and reluctant to undergo surgery for any reasons, and volunteered to participate in the study and ability to understand and the willingness to sign a written informed consent. patents are willing to pay for the treatment, and agreed to take a picture of the skin lesions. exclusion criteria: 1. those who had ala-pdt and any other studies that affect this study within 12 weeks ; 2. there are other facial diseases that may affect the efficacy evaluation, such as other photodermatosis; 3. take phototoxic or photosensitizer within 8 weeks; 4. clinical and / or pathological prove that the tumor has invaded other organs or tissues; 5. serious immunocompromised persons; 6. scar constitution; 7. patients are known to have skin photosensitivity, porphyria, or allergies to ala, light or lidocaine; 8. persons are suffering from severe internal diseases, mental and mental illness, infectious diseases or pregnant or lactating women.

Keywords: photodynamic therapy conventional painless actinic keratosis
glufast on insulin glargine trial in type 2 dm

Conditions: Diabetes Mellitus, Type 2

Summary: we will evaluate the efficacy and safety of combination therapy of 10 mg mitiglinide or 0.2mg voglibose with insulin glargine for 16 weeks after single administration of insulin glargine for 4 weeks in type 2 diabetic patients whose glycemic control were not enough despite administration of oral antidiabetic drug or insulin glargine.


Eligibility criteria:
inclusion criteria: * the type 2 diabetic patients aged between 30 and 70 * the patients whose hb1ac is over 7.0% despite administration of two or more oral antidiabetic drugs over 6 months or only insulin glargine over 3 months before registration * outpatients whose bmi is between 21 and 40 kg/㎡ * the patients who consented to participate in the clinical study in writing exclusion criteria: * the patients who have been using insulin formulation except insulin glargine * the patients whose fasting blood glucose is over 270 mg/dl * the patients whose c-peptide is under 1ng/ml on an empty stomach * the patients who was surgically operated of gastrointestinal tract * the patients who need additional treatment or who underwent operation within 3 months for severe complication such as diabetic foot ulcer, retinopathy and neuropathy * the patients with severe hepatic dysfunction : uncompensated hepatic cirrhosis, or the case where aspartate aminotransferase (ast) or alanine aminotransferase (alt) is over 2.5 times higher than the normal limit ( ≥ 2.5 x normal ranges) * the patients with unstable angina or acute myocardial infarction occurred within 3months * the patients with renal failure or severe hypertension : diastolic blood pressure is over 110mmhg despite drug treatment * the patients who have a life-threatening disease such as cancer or severe infection * the patients with a history of drug allergy * pregnant or breast feeding or the women who are likely to be pregnant * the patients who need oral or parenteral corticosteroids * the patients who were judged to be unsuitable to the clinical study by other reasons

Keywords: diabetes mellitus, type 2 mitiglinide
small nerve fiber activity in patients with carpal tunnel syndrome assessed via quantitative sensory testing

Conditions: Carpal Tunnel Syndrome

Summary: the diagnosis of carpal tunnel syndrome (cts) is typically based on clinical findings and confirmatory electrodiagnostic testing. however, electrodiagnostic testing can only assess large a-alpha and a-beta nerve fibers. quantitative sensory testing (qst) is a series of tests used to assess small nerve fiber changes in the a-delta, c-fibers, and a-beta nerve fibers as well. previous studies have used qst to assess small nerve fiber changes related to carpal tunnel syndrome and found changes compared to controls. this study will utilize a course of standard physical therapy care and assess for any changes to small nerve fiber activity and how those changes may or may not relate to patient outcomes.

purpose: to assess changes in a-beta, a-deta, and c-fiber function after standard physical therapy interventions in individuals with cts. specific aim 1 (primary aim): determine if a-beta, a-deta, and c-fiber functions change following a course of physical therapy (pt) in individuals with cts. specific aim 2 (secondary aim): describe the relationship between changes in qst and changes in a patient-reported outcome measure after a course of pt in individuals with a clinical diagnosis of cts. specific aim 3 (secondary aim): determine if there are differences in a-beta, a-deta, and c-fiber function between the affected and unaffected wrists in individuals with a clinical diagnosis of cts.

Eligibility criteria:
inclusion criteria: deers eligible age 18-65 pain and paresthesia in the median nerve distribution a positive phalen test a positive tinel test over the carpal tunnel willing to attend physical therapy exclusion criteria: nerve root signs consistent with a radiculopathy suspected radial and ulnar nerve involvement based on monofilament testing bilateral cts previous hand surgery injections in the upper quarter in the last 6 months cervical, shoulder, or ue trauma in the last 6 months currently pregnant or postpartum within the last 6 months no more than minimal care (evaluation and patient education, 1 visit) for the current episode

Keywords: carpal tunnel syndrome quantitative sensory testing median nerve neuropathy small nerve fiber
effects of natural sounds on attention restoration in noisy environment

Conditions: Cognitive Fatigue; Mental Fatigue; Heart Rate Variability; Skin Conductance; Behavioral Performance; Positive and Negative Affect; Inhibition; Working Memory; Perceived Restoration

Summary: this study aims to examine whether listening to natural sounds in a noisy (traffic) environment compared to traffic noise only impacts behavioural, cognitive, affective, and physiological markers associated with attention restoration. attention restoration will be examined as an aspect of cognitive fatigue.

based on the attention restoration theory (kaplan, 1995), we hypothesize that listening to natural sounds has restorative effects on attention by supporting greater use of involuntary attention. this generates the prediction that exposure to natural sounds in the context of a noisy environment will have greater restorative effects on attention (i.e., physiological, affect, cognition, and behaviour) as compared to the control group (exposed to noise only). individual differences (i.e., age, gender, caffeine and food intake, body mass index, skin temperature, noise sensitivity, sleep quality, baseline physiology and behavioural performance) will be examined and accounted for. a cognitive task will be administered at the beginning of the experiment to induce fatigue to examine the restorative effects of natural sounds.

Eligibility criteria:
inclusion criteria: * singapore-based * non-clinical * 18-35years exclusion criteria: * individuals with hearing difficulties or failing to meet the minimal threshold for normal hearing * individuals with a history of ear, developmental, neurological, or psychiatric disorder