Kornimate/medical-research-clean huggingface dataset:
basal tumours in bladder cancer, response to chemotherapy

Conditions: Bladder Cancer; Chemotherapy Effect

Summary: determine the sensitivity/resistance to chemotherapy of the various subgroups of muscle-invasive bladder cancers, including the basal subgroup (about 25% of these tumours) according to 4 different classifications based on molecular or immunohistochemical classifiers.


Eligibility criteria:
inclusion criteria of patients enrolled in vesper study: tumors from patient having muscle invasive bladder cancer who benefit from neoadjuvant chemotherapy with cisplatine included in vesper cohort and : * having signed an informed consent form for the participation to the collection or * dead/lost to follow-up without prior opposition expressed against research program, * genetic analysis will only be carried out for patients who have signed the genetic consent form. inclusion criteria of patients from st louis cohort not enrolled in vesper study: tumors from patient having muscle invasive bladder cancer who benefit from neoadjuvant chemotherapy with cisplatine included in saint-louis cohort and : * having received an informed form for the participation to the collection and not having expressed opposition against research program within 1 month or * dead/lost to follow-up without prior opposition expressed against research program, exclusion criteria: -patients enrolled in vesper study:tumors from patient having withdrawn his/her informed consent form for the participation to the collection and/or vesper project. or -patients from st louis not enrolled in vesper study:tumors from patient having expressed opposition against research program after 1 month for the participation to the collection.

Keywords: neoadjuvant chemotherapy cisplatine
performance of 3 sampling methods for the detection of sars-cov-2 (covid-19) with real-time reverse transcriptase pcr

Conditions: Covid-19; SARS-CoV-2; Diagnosis; Polymerase Chain Reaction

Summary: the performance of 3 different sampling methods (2 nasopharyngeal swabs, 1 oropharyngeal swab) for the detection of sars-cov-2 with real-time reverse transcriptase polymerase chain reaction will be compared.

thirty volunteers will be recruited from health care workers suspicious for covid-19, who consult the ocupational physician for covid-19 testing. for each volunteer, 3 swabs will be taken: * flocked eswab (copan, italy) of the oropharynx * flocked nasopharyngeal eswab (copan, italy) of the nasopharynx * dry flocked nasopharyngeal swab, placed in lysis buffer each swab will be tested for the presence of sars-cov-2 with an in-house reverse-transcriptase real-time pcr (egene). performance of each method will be calculated.

Eligibility criteria:
inclusion criteria: * health care workers with symptoms suspicious for covid-19 exclusion criteria: * none
effectiveness of an online psychoeducation program for improving coping in people with a high level of dissociative symptoms: a pilot randomized waitlist-controlled trial

Conditions: Dissociation

Summary: subject population our study's target population is people with pathological dissociation in the community. research design a pilot randomized waitlist-controlled trial will investigate the effects of an online psychoeducation program on coping, symptom management, and self-efficacy of people with pathological dissociation immediately (posttest-1) and 2-month (posttest-2) post-intervention. supplementary semi-structured interviews will be conducted for process evaluation. the analysis and reporting of the trial will strictly follow the consort guidelines. instrument the primary outcome of our study is the coping ability of individuals with pathological dissociation, which will be assessed by the brief coping orientation to problems experienced inventory (brief-cope). the secondary outcome measures are dissociative symptoms, emotional regulation, and self-efficacy, which would be assessed by the dissociative experiences scale-taxon (des-t), the emotion regulation questionnaire (erq), and the general self-efficacy scale (gses) accordingly. procedure the online psychoeducation program is developed based on an integrative theoretical framework that integrates the stress and coping model, cognitive-behavioural theory, bandura's self-efﬁcacy theory, and findings of our previous feasibility studies on this psychoeducational program. participants will be recruited via posting on social media and online forums. a 16-session online psychoeducation program will be delivered to the participants in eight weeks.


Eligibility criteria:
inclusion criteria: * agree to give informed consent and participate * aged 18 or above * self-reported symptoms or experiences of pathological dissociation * screened positive on the chinese version of the des-t (i.e., des-t score 20 or above) at a baseline screening * able to understand and communicate in chinese-cantonese * have access to the internet. exclusion criteria: * individuals who have a reading disorder, cognitive impairment, dementia, or intellectual disabilities * individuals who are participating in any research studies * individuals who had participated in our previous feasibility study of the same intervention
charged particle rt for chordomas and chondrosarcomas of the base of skull or cervical spine

Conditions: Chordoma; Chondrosarcoma

Summary: the primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose. most of the treatment will be given protons, but participants may receive a small portion of treatment with x-rays, because less radiation is given to the skin with x-rays. this study uses two slightly different doses of radiation it is not clear at this time which of the dose levels is better.

* participants will be assigned to a dose level by random chance, like flipping a coin. * a treatment plan will be determined by a treatment planning ct scan and will either involve 40-44 treatments or 37-40 treatments.

Eligibility criteria:
inclusion criteria: * biopsy proven chordoma. slides must be reviewed prior to randomization by the central review pathologist * sites: intercranial (sphenoid, clivus, petrous, basio-occiput) or cervical spine * boost target volume less than or equal to 150 * 18 years of age or older * karnofsky performance status \> 50 * neurologic function of i or ii * no evidence of metastases exclusion criteria: * previous radiation to the head or neck that would compromise the ability to deliver the prescribed treatment * concurrent or prior malignancy unless disease free for 5 or more years * evidence of metastatic disease * diabetes mellitus * major medical illness or psychiatric impairments that in the opinion of the investigator, will prevent administration or completion of the protocol therapy

Keywords: charged particle radiation therapy
long term safety & efficacy of budesonide inhalation suspension in japanese children with bronchial asthma

Conditions: Asthma

Summary: this study is as an extension study of sd-004-0765, to assess the safety profile of long-term use of budesonide inhalation suspension in japanese young children with bronchial asthma. children completing study sd-004-0765 continued administration of budesonide inhalation suspension as judged by the investigator; the dose is adjusted as appropriate within the range of 0.25 to 1.0 mg per day administered once or twice daily, according to the symptoms.


Eligibility criteria:
inclusion criteria: - 1. clinical benefit from continued treatment with budesonide inhalation suspension was expected in patients with bronchial asthma participating in study sd-004-0765, as judged by the investigator(s) at the completion of that study (visit 11, week 24), and the patient's caregiver wished the continued treatment with budesonide inhalation suspension a written consent to participate in this study had been obtained from the patient's legal representative (a person who exercises parental authority for the patient, or if no one was applicable, a guardian: in principle, the patient's parent). 3. the patient was younger than 5 years old. patients aged 5 years could be included in this study if no other effective treatment for the patient's bronchial asthma was available as judged by the investigator(s). exclusion criteria: -1. concurrent severe diseases of liver, kidney, heart or other complications. 2. contra-indications (eg, known or suspected allergy) to budesonide or excipients contained in the investigational product. 3. other conditions, in which the investigator(s) judges patient's participation in this study inappropriate.
a study to evaluate safety and effectiveness of bevacizumab in combination with paclitaxel and cisplatin/carboplatin or toptecan in participants with advanced cervical cancer

Conditions: Cervical Cancer

Summary: this study will evaluate the safety of bevacizumab (avastin®) combined with standard chemotherapy in participant with advanced cervical cancer, with special focus on the incidence of gastrointestinal (gi) and genitourinary (gu) fistulas and gi perforations in the common practice setting.


Eligibility criteria:
inclusion criteria: * age 18 or older * diagnosis of primary stage ivb, recurrent or persistent squamous cell carcinoma, adenosquamous carcinoma, or adenocarcinoma of the cervix which is not amenable to curative treatment with surgery and/or radiation therapy * retrospective clinical decision made to initiate therapy with bevacizumab (avastin®) combined with standard chemotherapy (cisplatin or carboplatin or topotecan and paclitaxel) between 01 january 2015 and 01 january 2016 * all participants must have received at least one dose of bevacizumab combined with standard chemotherapy between 01 january 2015 and 01 january 2016 and have at least 12 months of documented follow up, from treatment start, unless died or lost to follow up within the minimum study entry follow up period * availability of documentation of for advanced cervical cancer (including prior treatment as applicable) and follow up in the participant's medical records exclusion criteria: * participation during the study period in an interventional clinical trial or any other interventional study that may impact advanced cervical cancer outcome * participants who have received prior therapy with any anti-vegf drug, including bevacizumab
performance of ct parameters compared to bone mineral density to detect bone fragility in rheumatoid arthritis

Conditions: Osteoporosis; Rheumatoid Arthritis; Vertebral Fracture

Summary: objective: to evaluate the performance of ct parameters (sbac-l1 and fractal analysis) compared to bmd (gold standard) to detect vertebral fractures in rheumatoid arthritis

to evaluate the performance of scanographic bone attenuation coefficient of the first lumbar vertebra (sbac-l1) and fractal analysis, markers of bone fragility on computed tomography (ct), compared to bone mineral density (bmd) to detect vertebral fractures in rheumatoid arthritis (ra). patient and methods: rheumatoid arthritis patients followed from 2009 to 2019 in nancy university hospital who met the 2010 acr/eular criteria for ra and examined using thoraco-abdomino-pelvic ct (tap-ct) and bmd (spine, hip) within a period of up to 2 years were included. scanographic bone attenuation coefficient and fractal dimension of the first lumbar vertebra (sbac-l1, fd-l1) were measured on ct. vertebral fractures of the thoracolumbar spine were evaluated on ct according to an adaptation of genant's scoring method. demographic characteristics (age, sex, smoking), clinical data (disease duration, das-28), biological data (c-reactive protein (crp), rf, acpa) and treatments (n proton pump inhibitor, corticosteroid, tnf-inhibitors (tnfi) and others biologics, calcium, vitamin d, antiresorptive agents) were collected from the complete medical record. univariate and multivariate analysis were performed to determine if these variables were associated or not with bone fragility (vertebral fracture, sbac-l1, fd-l1). we evaluated the performance and diagnostic complementarity as well as optimal diagnostic thresholds of sbac-l1, fd-l1 and bmd (gold standard) to detect vertebral fractures in these patients at risk of osteoporosis. intra and inter-readers reproducibilities of the scanographic screening methods (sbac-l1, fd-l1) were also studied.

Eligibility criteria:
inclusion criteria: * rheumatoid arthritis patients followed from 2009 to 2019 in nancy university hospital who met the 2010 acr/eular criteria for ra * thoraco-abdomino-pelvic ct (tap-ct) and bmd (spine, hip) within a period of up to 2 years
satisfaction with care and quality of life

Conditions: Chronic Disease

Summary: investigating the predictive value of patient satisfaction with care on 6 months and 1-year quality of life.

background: evaluating the impact of complex procedures of patient care for chronic disease patients is one of the objectives and priorities defined in the french framework of the public health act of august 2004. the relevant indicators that predict the impact of the medium-term hospitalization on the quality of life remain to be explored. preliminary data showed that care satisfaction, usual indicator of quality of care, was associated with quality of life away from the hospital, especially in the field of orthopedics (prosthetic surgery). satisfaction is an indicator currently collected in routine periodic surveys in all establishments. this project will test the hypothesis of the prognostic role of this satisfaction after a medical or a surgical treatment in people hospitalized for chronic disease. objective: the objective of this research is to investigate the prognostic value of satisfaction with care on the quality of life of patients with chronic disease hospital, at 6 months and 1 year of discharge. patients and methods: a multicenter cohort of 1520 patients hospitalized in medical and surgical units for chronic disease (in the field of cardiovascular, musculoskeletal, nephrology, urology, digestive, pulmonary or endocrine). patients will respond to pjhq satisfaction questionnaire at the waning of their hospital stay. the quality of life (sf-36) will be measured at 6 months and 1 year after hospitalization. the socio-demographic characteristics, diagnosis, anxiety state (had), optimistic / pessimistic personality (lot-r), comorbidities (charlson and functional comorbidity index), major health events (rehospitalization, death ) and the characteristics of the stays and care structure (cluster services) who welcomed them will be saved. the number of subjects required was calculated based on a cluster sampling (13 poles or services between institutions) to highlight with a power of 80% a difference of 5 points of quality of life among the satisfied and less satisfied subjects. statistical analysis will study the relationship of satisfaction scores with qol dimensions at 6 months and 1 year, in hierarchical regression multilevel models adjusted for confounding variables.

Eligibility criteria:
inclusion criteria: * age: 40-75 years * patients hospitalized for treatment of chronic disease, defined as a disease lasting for more than 6 months, and confirmed by a validation committee * hospitalization motivation is: * a care of an acute episode of a chronic disease * a car of a worsening of chronic disease * a new therapeutic of a chronic disease exclusion criteria: * patients who did not have a therapeutic intervention during their hospitalization (i.e., diagnostic analysis or medical follow-up without change of their treatment) * patients with more than 5 hospitalizations during the previous 5 years (more than 1 per year)
influence of main psychological and social factors on primary headaches

Conditions: Headache, Migraine

Summary: this study aims to describe the psychological and social characteristics of patients suffering from primary headache and monitored in neurology department of besançon university hospital

the aim of our study is to describe the psychological patterns in a population of patients suffering of episodic migraine or chronic migraine with and without medication overuse and the level of disability. data about migraine characteristics will be obtained using a standardized questionnaire. socio-demographic data will be obtained for all patients including gender, age, educational level and professional status. a booklet of 10 self-administered questionnaires will permit to measure psychological factors such as depression, anxiety, alexithymia...

Eligibility criteria:
inclusion criteria: * patients from 25 to 60 ans y.o suffering from primary headache and monitored in the neurology department of besançon university hospital exclusion criteria: * patients with former or current psychic troubles
viscoelastic tests-guided therapy in liver transplantation

Conditions: Liver Transplant; Complications; Bleeding; Hemostatic Disorder

Summary: background: perioperative bleeding and transfusion are important causes of morbidity and mortality in patients undergoing liver transplantation. the aim of this study is to assess whether viscoelastic tests-guided therapy with the use of synthetic factor concentrates impact transfusion rates of hemocomponents in adult patients undergoing liver transplantation. methods: this is an interventional before-after comparative study. patients undergoing liver transplantation before the implementation of a protocol using thromboelastometry and synthetic factor concentrates were compared to patients after the implementation. primary outcome was transfusion of any hemocomponents. secondary outcomes included: transfusion of red blood cells (rbc), fresh frozen plasma (ffp), cryoprecipitate or platelets, clinical complications, length of stay and in-hospital mortality.


Eligibility criteria:
inclusion criteria: * deceased donor liver transplantation * chronic liver disease exclusion criteria: * acute liver failure * combined transplantation * re-transplantation is less than 30 days after the first transplant

Keywords: liver transplantation blood coagulation disorders blood transfusion hemostasis thromboelastometry
prehospital traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: the aim of the study is to measure the effect of finnish physician-staffed ems unit treatment methods on traumatic brain injury (tbi) patient prognosis.

a secondary aim is to identify out-of-hospital treatment factors that can be influenced by education and protocols.

Eligibility criteria:
inclusion criteria: * tbi with gcs ≤ 8 or unconsciousness verified by an on-call neurosurgeon during admission to the hospital. exclusion criteria: * multiple trauma

Keywords: traumatic brain injury ems out-of-hospital
study to test genetic alterations among different dermoscopic types of melanocytic nevi.

Conditions: Nevi

Summary: this project is a multicenter study in which we will investigate a dual concept of nevogenesis. study location is the department of dermatology at the medical university of graz in collaboration with centers in austria (vienna), italy (naples, benevento, modena), spain (barcelona) and the united states (new york). the hypothesis is that small congenital melanocytic nevi (cmn), "early" acquired melanocytic nevi in childhood (amn) and dermal nevi, all dermatoscopically characterized by globular pattern, belong to the same spectrum of genetically determined melanocytic proliferations that develop due to endogenous pathways, in contrast to "true" acquired melanocytic nevi, dermatoscopically showing reticular pattern, that develop due to exogeneous factors such as uv-exposure.

the investigations to this study will verify whether small cmn, "early" amn and dermal nevi, characterized by globular pattern differ in their genetic alterations compared to reticular typed nevi. it will be expected that globular typed nevi and eventually dermal nevi lack b-raf mutations whereas reticular nevi show alterations in the b-raf gene. study location: graz

Eligibility criteria:
inclusion criteria: * healthy individuals aged 9 to 80 years showing one or more dermoscopically benign nevi with either uniform globular-cobblestone pattern or reticular pattern or a combination of both types exclusion criteria: * children under the age of 9 years * pregnant woman * patients with atypical nevi (i.e., melanoma cannot be clinically ruled out) * patients with immunosuppression * patients with sun exposure 4 weeks before enrollment

Keywords: dermoscopy histopathology genetics nevi nevogenesis
vaccine for recurrent urinary tract infections in women

Conditions: Recurrent Urinary Tract Infections in Women

Summary: the purpose of this study is determine whether a vaginal mucosal vaccine given to women with a history of recurrent urinary tract infections can reduce the number of infections occurring in a six-month study period, as compared to placebo treatment.

recurrent urinary tract infections (utis) affect approximately 10% of women in the united states. since antibiotic prophylaxis is not always effective, alternate treatments need to be developed. one such treatment would be immunization with a vaccine containing bacteria known to cause these infections. the objective of the study is to immunize susceptible women with inactivated bacteria contained in a vaginal suppository and to monitor the rates of reinfection compared to a group of women treated with placebo suppositories. each group of patients will receive a total of six suppositories in the first four-months of the six-month study during which all utis and side effects will be recorded. the infection rates between vaccine- and placebo-treated women will be statistically analyzed to determine vaccine efficacy.

Eligibility criteria:
inclusion criteria: * three or more urinary tract infections in the previous year exclusion criteria: * neurogenic bladder * interstitial cystitis * urinary diversion * kidney stones * indwelling catheter

Keywords: phase 2 vaccine urinary tract infection vaginal mucosal