Kornimate/medical-research-clean huggingface dataset:
impact of inflammatory indexes and gene scores in prediction of atrial fibrillation

Conditions: Atrial Fibrillation; Inflammation; Genetic Predisposition to Disease

Summary: because of the high recurrence rates following electrical cardioversion and high morbidity in af patients there is a need to explore prediction models for af recurrence following ecv. previous studies have primarily focused on high-sensitivity crp (hscrp), crp, and il-6, while other inflammatory indexes and gene scores might hold greater value. this prospective cohort study is planning to include 182 patients with persistent atrial fibrillation, planned for electrical cardioversion, and \&gt;18 years at two medium-sized hospitals in sweden. blood samples will be collected prior to electrical cardioversion and at 7-, 30-, 90-, and 180-days follow-up. atrial fibrillation recurrence will be evaluated at follow-up or upon patient request and diagnosed with 12-lead ecg. an interim analysis will be conducted after more than 80 patients have been included. if the results from univariate and/or multivariable logistic regression on inflammatory markers and genetic expression regarding atrial fibrillation recurrence are significant, the study will be concluded.


Eligibility criteria:
inclusion criteria: * persistent atrial fibrillation (icd-10 i48.1) * age over 18 years exclusion criteria: * autoimmune disease * inflammatory diseases * acute or chronic liver dysfunction * ongoing infectious diseases * thyroid disorders * any other conditions known to impact inflammatory activity (including medication use and hematological diseases)
local phase 4 pan-european smart study

Conditions: Asthma

Summary: the purpose of this study is to evaluate the effect of two different maintenance doses of symbicort maintenance and reliever therapy (smart) in adult asthmatic patients. a 6 month treatment period


Eligibility criteria:
inclusion criteria: * patients at out-patient clinics * \>18 years with a minimum of 6 months documented history of persistent asthma who have used inhaled glucocorticosteroids for at least one month and have a history of use in rapid-acting b2 agonists for symptom relief exclusion criteria: * asthma exacerbation within the last 14 days prior to study start * subject aged \>40 years with a smoking history of \>10pack-years * subjects with chronic obstructive lung disease or other significant respiratory disease

Keywords: asthma
evaluation of perioperative celecoxib for hip arthroscopy

Conditions: Hip Labral Tears

Summary: celecoxib is commonly used for perioperative pain control for certain orthopaedic procedures. it has been shown to be successful in assisting in pain control for knee arthroscopy. it has not previously been studied in hip arthroscopy. this is a double blinded randomized controlled trial to determine the efficacy of celecoxib in perioperative pain control for hip arthroscopy.

this study examines the efficacy of perioperative dose of celecoxib in pain management after hip arthroscopy. perioperative administration of celecoxib has been shown to improve pain control after knee arthroscopy, but this has not yet been studied in the hip. in this study, patients are randomized to receive either 400mg celecoxib or placebo 1 hour prior to undergoing hip arthroscopy surgery. postoperatively, patients are monitored for pain on the vas scale, narcotic use, and meeting discharge criteria. the study will enroll 100 patients. patients are approached for informed consent on the day of surgery. pain scores, narcotic use, and time to discharge in the celecoxib group are compared to the placebo group.

Eligibility criteria:
inclusion criteria: * all patients who are undergoing a hip arthroscopy procedure at northwestern memorial hospital with dr. michael terry. exclusion criteria: * pregnant women and any patient under the age of 18 years.

Keywords: hip arthroscopy
psychophysiological effects of music

Conditions: Sadness

Summary: this study employed a repeated measure between-subjects design. two groups (i.e., depressed group and non-depressed group) of participants were recruited. each participant experienced four stages: baseline, neutral control, sadness induction, and music intervention. the outcome variables were self-reported emotion and heart rate variability features. emotions were reported at the end of every stage. electrocardiogram signals were recorded throughout the experiment.


Eligibility criteria:
inclusion criteria: * aged 18-30 years * right-handed * no recent illness or medication use * no history of neurological or psychiatric disorders * normal or corrected-to-normal visual acuity (myopic participants wore glasses) * normal hearing exclusion criteria: * incapable of giving written informed consent to this study * acute high suicide risk at baseline assessment * psychosis

Keywords: music depression emotion heart rate variability
carotid pet/mri with dotatate in patients post head and neck radiation therapy

Conditions: Head & Neck Cancer

Summary: the improvement of comprehensive multi-modality treatment and radiotherapy (rt) technology has resulted in an improved survival rate of head and neck malignancies within recent decades. as survival increases, late toxicity from cancer therapy becomes a larger burden. radiation induced vascular injury following rt is a recognized complication of radiotherapy. diagnosis of vascular changes predominately relies on non-invasive imaging techniques. doppler ultrasound assessment has been proven as a good indicator of diffuse atherosclerotic disease and a significant predictor of future vascular events. new opportunities are provided by the recent introduction of the hybrid pet/mri scanners for investigating the synergistic effect of these two modalities without the challenge of image co-registration. it has been shown that the pet system integrated with the mri scanner performs the same as the pet portion of a pet/ct for various cancers and cardiovascular indications. mri allows better delineation of the carotid artery and atherosclerotic plaque when compared with ct due to the superior soft tissue contrast. the pet/mri system acquires the pet and mri simultaneously allowing for perfect alignment between the 2 sets of images, when compared with the sequential acquisition in pet/ct where minor head movements can cause misalignment. there is evidence in the literature that 68-ga dota-tate pet-imaging can serve as a surrogate marker for evidence of invasion into the vessel wall and thereby possibly detects early, developing atherosclerotic plaque. thus, combined pet and mr with 68-ga dota-tate should be a promising imaging tool to screen and characterize patients at risk for radiation induced carotid injury. in this study, dotatate-pet/mr will be performed in up to 60 patients with a history of radiation therapy for head and neck squamous cell carcinoma over 2 years.


Eligibility criteria:
inclusion criteria: * previously treated with radiation for head and neck malignancy; * age group: ≥30 years; * patients who have no contraindications to pet/mri; * no allergy to contrast agents. exclusion criteria: * pregnant females; * age group: \< 30 years; * allergy to mr contrast agents; * pacemakers/icd/claustrophobic patients.
study evaluating the safety and efficacy of ar-15512 (comet-3)

Conditions: Dry Eye Disease

Summary: this will be a phase 3, multicenter, vehicle-controlled, double-masked, randomized study conducted at approximately 20 sites in the united states. all subjects enrolled will have dry eye disease (ded). the study will consist of screening (day -14) and baseline (day 1) visits as well as visits at day 7, day 14, day 28, and day 90 (study exit).


Eligibility criteria:
inclusion criteria: * male or female, 30 years of age or older at the screening visit * signs of ded at the screening and baseline visits assessed by corneal staining and schirmer test * symptoms of ded at both screening and baseline visits assessed by sande questionnaire and ods-vas * corrected visual acuity (+0.70 logmar) or better in both eyes at both the screening and baseline visits exclusion criteria: * history or presence of any ocular disorder or condition (other than ded) in either eye that would, in the opinion of the investigator, likely interfere with the interpretation of the study results or subject safety * regular use of lid hygiene within 14 days prior to the screening visit or any planned use during the study * use of artificial tears within 2 hours prior to the screening visit or anticipated use during the study * use of any topical ocular anti-inflammatory medication within 30 days prior to the screening visit or anticipated use during the study (e.g., ocular cyclosporine \[restasis®, cequa™\], lifitegrast \[xiidra®\], or any other prescription ophthalmic product for ded, topical ocular corticosteroid- or non-steroidal-anti-inflammatory agents * use of tyrvaya™ (varenicline solution, nasal spray 0.03mg) within 30 days prior to the screening visit or anticipated use during the study * use of medications for the treatment of severe ded and/or meibomian gland disease such as oral pilocarpine, oral cevimeline, oral macrolides, oral tetracyclines, oral tetracycline derivatives, and oral retinoids within 30 days prior to the screening visit or anticipated use during the study. * initiation, discontinuation, or change in dose of a systemic medication known to cause ocular drying (e.g., antihistamines or tricyclic antidepressants) less than 14 days prior to the screening visit or a change in dosage is anticipated during the study. * initiation, discontinuation, or change in dose of a systemic corticosteroid less than 60 days prior to the screening visit or a change in dosage is anticipated during the study. * initiation, discontinuation, or change in dose of a systemic immunomodulator (e.g., hydroxychloroquine, methotrexate, cyclosporine) less than 60 days prior to the screening visit or a change in dosage is anticipated during the study * history or presence of significant systemic disease (i.e.: cardiovascular, pulmonary, hepatic, renal, hematologic, immunologic)
pain management in arthtroscopic shoulder surgery

Conditions: Arthroscopic Shoulder Surgery

Summary: it is compared that combined suprascapular and infraclavicular nerve blocks to interscalene nerve block for clinical outcomes after shoulder surgery

in this study, the investigators planned to investigate postoperative pain, analgesic dosage, respiratory effects of the block and side effects of patients undergoing general anaesthesia after arthroscopic shoulder surgery under preoperative interscalene nerve block or suprascapular + infraclavicular nerve block.

Eligibility criteria:
inclusion criteria: * patients scheduled for elective shoulder surgery under general anesthesia with suprascapular + infraclavicular nerve block or interscalene nerve block for any reason asa 1-3 patients exclusion criteria: * diabetes * coagulopathy * local anesthetic allergy * chronic opioid users * neurological deficit of the surgical limb * obstructive or restrictive pulmoner disease * inability to understand pain scores
women's activity and lifestyle study in connecticut

Conditions: Ovarian Cancer

Summary: despite an increase in longevity, surviving ovarian cancer often brings an array of unpleasant side effects and compromises in qol. our proposed trial will be the first study to test whether exercise compared with attention control has a beneficial impact on quality of life, fitness and surrogate markers of ovarian cancer. our trial could suggest a unique and important role for exercise in ovarian cancer care given that physical and functional aspects of qol are often the most compromised in ovarian cancer patients.

currently, the american cancer society recommends a physically active lifestyle for cancer survivors to increase disease-free survival from cancer and other chronic diseases, and to improve quality of life. studies of a strong benefit of physical activity on improving qol following other types of cancer treatment, e.g., breast cancer, are well documented in the literature; yet very few studies of physical activity and qol after a diagnosis of ovarian cancer have been published. therefore, clinical trials of exercise on common physical and psychological consequences of ovarian cancer and its treatments are warranted. the primary aims of our study are to examine, in 230 women who have completed treatment for stage i-iv ovarian cancer, the impact of a moderate-intensity aerobic exercise intervention vs. attention control on: * quality of life * body composition (weight, bmi, total and % body fat, waist and hip circumference) * hormones possibly associated with physical activity and ovarian cancer prognosis (insulin, igf-i, igf-ii, igf binding protein-3, crp, leptin, estrone, estradiol, free estradiol, and sex-hormone binding globulin, osteopontin, mif, prolactin, and ca-125) * cardiorespiratory fitness - an objective measure of functional capacity and adherence to exercise. hypotheses: women randomized to exercise will experience improvements in quality of life, body composition, hormone levels, and cardiorespiratory fitness compared to women randomized to usual care. our trial could suggest a unique and important role for exercise in ovarian cancer care given that physical and functional aspects of qol are often the most compromised in ovarian cancer patients.

Eligibility criteria:
inclusion criteria: * stage i-iv ovarian cancer * less than 76 yrs of age exclusion criteria: * exercising

Keywords: exercise physical activity ovarian cancer quality of life fatigue weight
network dysregulation among individuals with comorbid tinnitus and ptsd

Conditions: Stress Disorders, Post-Traumatic; Tinnitus

Summary: evaluation of the overlap between tinnitus-related distress and symptoms of post traumatic stress disorder (ptsd), to identify functional covariance among resting-state networks among individuals with tinnitus and ptsd

the purpose of this study is to characterize tinnitus and ptsd symptomatically, neurobiologically, and causally, applying causal modeling to psychometric and neurofunctional data. we will enroll 30 individuals with both tinnitus and ptsd. participants will be asked to complete baseline assessments of subjective tinnitus distress, ptsd, depression, and resting-state fmri at baseline. individuals with comorbid tinnitus and ptsd who are eligible for the study will receive 12 sessions of cognitive processing therapy (cpt) over a 6- to 15-week period. cpt is a trauma-focused treatment for ptsd that guides individuals on how to recognize and challenge thoughts that are erroneous and dysfunctional. one-month follow-up assessments of tinnitus-related distress, ptsd, depression, and anxiety will be conducted, along with resting-state functional magnetic resonance imaging (fmri).

Eligibility criteria:
inclusion criteria: * adult military veterans (age 18-60) who deployed in support of combat operations post-9/11 seeking behavioral health treatment for ptsd and/or tinnitus * diagnosis of ptsd determined by the clinician-administered ptsd scale - interview - version 5 (caps-5) * ability to speak and read english * meets criteria for tinnitus and considers their tinnitus bothersome, as defined by a score on the tinnitus functional index of 32 or greater exclusion criteria: * currently receiving evidence based treatment for ptsd * current suicidal ideation severe enough to warrant immediate attention (as determined by the depressive symptoms index- suicidality subscale and corroborated by a clinical risk assessment by a credentialed provider * psychiatric hospitalization in the last 12 months * current and severe alcohol use warranting immediate intervention based on clinical judgment * current manic episode or psychotic symptoms requiring immediate stabilization or hospitalization (as determined by the manic and psychosis modules of the mini) * evidence of a moderate or severe traumatic brain injury (as determined by the inability to comprehend the baseline screening questionnaires) * neurobiological disorders * meniere's disease, temporomandibular joint disorders * history of seizures * history of penetrating head trauma or neurosurgery * metal objects implanted in the head, ferrous metal filings in the eye * inflammation of the brain * cardiac pacemaker * implanted medical pump or cardiac lines * heart disease * currently taking certain types of medication for depression or seizures (tricyclic antidepressants or neuroleptics which lower seizure threshold)
diet and hip fracture risk in the united kingdom women's cohort

Conditions: Hip Fracture (First Incidence of)

Summary: hip fracture is a common serious injury in older women that reduces quality of life and can lead to premature death. in the united kingdom, hip fractures are estimated to account for 1.5 million hospital bed days used per year due to long hospitalisation and rehabilitation periods post-surgery, costing the national health service over £1 billion per year. diet can affect bone health and risk of hip fracture, with varying risks in women on specific diets, and specific foods and nutrients playing more important roles than others. vegetarians may be at a greater risk of hip fracture than meat-eaters, and those who don't consume enough protein could be at a greater risk than those with adequate intakes. this research aims to investigate which dietary factors (and in what quantities) might predispose united kingdom women to a greater risk of hip fracture, and which factors may be protective. the purpose of this study is to better understand the role of diet in reducing hip fracture risk in united kingdom women. the research will use existing dietary and lifestyle data from the united kingdom women's cohort study and hospital records of hip fractures.

background: hip fracture is an increasingly prevalent global health condition that increases morbidity and mortality. previous observational studies have shown potential for risk reduction through diet modification, but associations between many dietary factors and hip fracture incidence are uncertain, and evidence in united kingdom populations is limited. therefore, this study aims to assess associations between diet and hip fracture incidence in the united kingdom women's cohort. research plan and methods: the investigators will utilise dietary and lifestyle data from the united kingdom women's cohort which recruited 35,372 middle-aged women between 1995-1998. this data has been linked with hospital episode statistics to provide hip fracture data of participants. cox regression models will be applied to explore potential associations between dietary factors and hip fracture incidence. dietary factors will be modelled both as categorical and continuous so that models can be fit comparing the risk of hip fracture between categories of intakes and per increment increase in exposure intake (linear dose-response). cubic splines will be used to model non-linear associations for dietary intake of fruits, vegetables, tea, and coffee since previous research has suggested possible non-linear associations for these variables.

Eligibility criteria:
inclusion criteria: * female * ages 35 - 69 years at time of recruitment * able to provide informed consent exclusion criteria: * male * not a resident of england * unable to link dietary and lifestyle data with hospital episode data * missing covariate data * hip fracture or osteoporosis prevalence before or on the date of recruitment

Keywords: nutrition fracture cohort study epidemiology osteoporosis
assessment of quality of life and social support gained in patients before and after colorectal cancer surgery

Conditions: Colorectal Cancer

Summary: * evaluation of the quality of life of patients before and after laparoscopic surgery for rectal cancer and cancer of the right part of the intestine at different stages of the disease, whether it depends on the size of the tumor, neoadjuvant treatment, type of cancer and its location * multidimensional assessment of perceived social support (considering three sources of support: significant person, family and friends) of patients before and after laparoscopic surgery for rectal cancer and cancer of the right part of the intestine, whether it depends on the stage of the disease, the location of the tumor lesion and the treatment undertaken

specific scientific objectives: * to evaluate the quality of life of patients before and after laparoscopic surgery for rectal cancer and right-sided colon cancer at different stages of disease, whether it depends on tumor size, neoadjuvant treatment, type of cancer and its location * multidimensional evaluation of perceived social support (considering three sources of support: significant person, family and friends) of patients before and after laparoscopic surgery for rectal cancer and cancer of the right part of the intestine, whether it depends on the stage of the disease, the location of the tumor lesion and the treatment undertaken scientific (research) problems: * what is the quality of life of patients before surgery, and what is the quality of life after laparoscopic surgery for rectal cancer and cancer of the right side of the intestine at different stages of oncological disease? does quality of life depend on the size of the tumor, location, advancement or type of treatment undertaken? * how do patients rate the received social support both before and after laparoscopic surgery for rectal cancer and right colon cancer ? * did the obtained social support in the patient at each stage of the disease ( before surgery, after surgery) depend on the advancement of the oncological lesion, the location of the tumor lesion and the treatment undertaken ? 2 methodology of the study the study will be carried out at the general surgery clinical department of the john grande hospital of the order of st. john of god in krakow after obtaining permission from the facility's management. each patient qualified for laparoscopic surgery for rectal cancer and cancer of the right side of the intestine who simultaneously agreed to participate in the study anonymously was included in the study group.

Eligibility criteria:
inclusion criteria for the study: * clinical diagnosis of rectal cancer and right colon cancer * laparoscopic surgery study exclusion criteria: - surgery by traditional method
brazilian heart-prevent meal - a pilot randomized clinical trial

Conditions: Cardiovascular Diseases

Summary: the purpose of this study is to evaluate the effectiveness of a brazilian cardioprotective diet plan to reduce cardiovascular risk factors of new cardiovascular events.

cardiovascular diseases are the leading cause of mortality in both sexes in brazil and worldwide. modifying risk factors such as diet and lifestyle can prevent most cases of cardiovascular disease. this pilot trial is based on specific and traditional brazilian food. the objective is to reduce risk factors such as obesity, high blood pressure,dyslipidemia and diabetes in patients with cardiovascular disease history.

Eligibility criteria:
inclusion criteria: * any coronary artery disease evidence in the past 10 years; or any ischemic stroke or tia evidence in the past 10 years; or peripheral arterial disease in the past 10 years; or at least one of the following additional risk factors: * diabetes mellitus; hypertension; dyslipidemia; coronary artery disease family history; * asymptomatic carotid artery disease; * body mass index\> 25 kg/m2 for adults and\> 28 kg/m2 for seniors exclusion criteria: * neurocognitive or psychiatric condition; * life expectancy less than 6 months (eg, metastatic malignancy or other defined as clinical trial investigators). * pregnancy or breast feeding. * hepatic impairment defined as elevated liver enzymes above three times the upper limit of normal * renal impairment defined as creatinine values higher than 1.5 mg/dl.