Kornimate/medical-research-clean huggingface dataset:
motivation makes the move!

Conditions: Obesity; Cardiovascular Diseases; Physical Conditioning

Summary: this study evaluates the effect and usability of mobile and cloud technology -based intervention on lifestyle modification in 18-40 year obese and overweight subjects. the study has a dose-response design with three randomized subjects groups from mode 1 to mode 3 with increasing intensity of intervention (guidance, exercise program, diet, support). the special focus of this study is on motivation and use of music and mobile health devices as motivational tools to support individualized exercise training, healthy diet and overall healthy life style.

obesity negatively impacts health in many ways. it is associated with metabolic diseases and mood disorders and in women pregnancy outcome as well as the health of the offspring. the modern evolution of societies steers populations towards a profound sedentary lifestyle. physical activity brings about health benefits, however, the risk reduction for chronic diseases remains significantly greater for fitness than physical activity per se. the recent knowledge suggest individualized approach rather than general guidelines for exercise in prevention-oriented strategies. in this study we compare three different intensities of lifestyle intervention: 1) general guidelines for healthy exercise and diet, 2) individual program,and 3) highly individual program. individual programs will be based on pre-examinations including interview and clinical exercise test. mobile and cloud technologies will be used to collect data and steer the subjects´ lifestyles and daily activities and together with music to motivate them. the duration of the active intervention is 3 months and it will continue on a self-governing basis up to 1 year. the primary outcome is maximal oxygen consumption (vo2max), and secondary outcomes are physical activity, cardio-respiratory and cardiovascular parameters, blood volume, total hemoglobin mass, metabolic health along with chronic low-grade inflammation and well-being.

Eligibility criteria:
inclusion criteria: * bmi ≥ 27,5 kg/m2 * estimated by health care personnel to benefit from lifestyle modification exclusion criteria: * inability to perform exercise testing and intervention (physical, mental or other reason) * not able to operate in finnish (some applications only in finnish for the time being) * severe anemia (hb\<108 g/l for women and \< 124 g/l for men) * smoking (disturbs autonomic nervous system measurements) * regular medication affecting glucose metabolism (excluding insulin) or autonomic nervous system (e.g. beta blockers, ssri) * ongoing pregnancy or breast feeding * prisoner
the use of nasal phenylephrine in infants with bronchiolitis

Conditions: Bronchiolitis

Summary: drops of either saline or phenylephrine are placed in the nose of infants less than 12 months of age to determine if it helps them to breathe easier.


Eligibility criteria:
inclusion criteria: * age 4 weeks to 12 months; admitting diagnosis of bronchiolitis; admitted to hospital's bronchiolitis pathway, admitted during weekdays, need for nasal suctioning. exclusion criteria: * congenital heart disease, history of hypertension, previous wheezing, prior use of inhaled corticosteroids, gestational age at birth of \<34 weeks.
a study of the pk interaction of cxa-10 with pravastatin and vytorin® in healthy males

Conditions: Acute Kidney Injury

Summary: this is an exploratory study in a small, well controlled group of healthy subjects to explore the effect of cxa-10 on pravastatin and vytorin® (combination of simvastatin and ezetimibe).

this is an exploratory study in a small, well controlled group of healthy subjects to explore the effect of cxa-10 on pravastatin and vytorin® (combination of simvastatin and ezetimibe). the overall design of the trial is to administer drugs that are metabolized through these transporters to quantify the impact cxa-10 may have on the exposure of these drugs. the study will also examine the 24-h urine total creatinine excretion prior to and following administration of cxa-10 to examine the effects of cxa-10, if any, either directly on creatinine transporters or through enhanced creatinine production. to reduce the potential variability in drug exposure levels, the study population will only include male subjects between 19 to 25 years of age.

Eligibility criteria:
inclusion criteria: * in good general health as determined by a thorough medical history and physical examination, ecg, vital signs, and clinical laboratory evaluation. results of clinical laboratory tests must be without clinically significant abnormalities for this population and may exceed the limits of the reference ranges, including hematology, clinical chemistry and urinalysis except as noted below. * resting hr greater than or equal to 45 beats per minute (bpm) after 5 minute rest at screening. * qtcf interval must be less than or equal to 430msec at screening and pre-dose. exclusion criteria: * any clinically relevant abnormality for this population identified on the screening history, physical or laboratory examinations, or any other medical condition or circumstance making the volunteer unsuitable for participation in the study. * any clinical history of cardiovascular events, arrhythmias, fainting, palpitations, personal or family history of congenital prolonged qt syndromes or sudden unexpected death due to a cardiac reason. * treatment with any prescription or non-prescription drugs (including vitamins, herbal and dietary supplements) within 7 days or 5 half-lives, whichever is longer, prior to dosing and until collection of the final pk sample. * history of smoking, including e-cigarettes, or use of nicotine-containing products within 1 month of screening. * subjects with any other clinically relevant ecg parameter abnormality (e.g., pr interval, qrs deviation) or any clinically significant ecg abnormality will be excluded from the study.
ultrasound-guided percutaneous electrical stimulation on radial nerve in patients with lateral epicondylalgia

Conditions: Tennis Elbow

Summary: lateral epicondylalgia is a common musculoskeletal condition that approximately affects 1-3% of the general population. several authors have found greater mechanical pain sensitivity in the radial nerve when compared with healthy subjects. radial tunnel syndrome exhibits a similar clinical presentation to lateral epicondylalgia. percutaneous electrical stimulation has shown reduce pain in several conditions. percutaneous electrical stimulation on the radial nerve could cause an important relief in lateral epicondylalgia. hypothesis: percutaneous electrical stimulation on radial nerve plus exercise therapy in patients with lateral epicondylalgia is better than sham percutaneous electrical stimulation plus exercise.

randomized, double-blind, placebo controlled clinical trial, using percutaneous electrical nerve stimulation (pens). pens is technique to provide a transcutaneous electrical nerve stimulation current throughout needling filaments place close to the nerve. study aims: aim #1: the primary aim of the study is to compare the effect of the short, mid and long-term of pens on intensity of pain as measured by numeric pain rating scale and disability as measured by patient rated tennis elbow evaluation (prtee) in patients with lateral epicondylalgia with random assignment to two treatments: pens plus exercise program or sham pens plus exercise program. aim #2: the secondary aim of the study is to compare the effect of the short, medium and long-term of pens on disability as measured by dash questionnaire, and psychological factors (fear and avoidance and catastrophism) and global rating of change (groc) in patients with lateral epicondylalgia with random assignment to two treatments: pens plus exercise program or sham pens plus exercise program.

Eligibility criteria:
inclusion criteria: * lateral epicondylalgia symptoms confirmed with at least 2 of the 4 following test: 1. pain during palpation of lateral epicondyle 2. pain on resisted wrist extension 3. pain on resisted middle finger extension 4. pain during hand-grip. exclusion criteria: * history of fractures, luxations, surgery and/or musculoskeletal disorders in upper limb. * neurological disorders, inflammatory and/or degenerative diseases. * having received as treatment techniques that involve needles on the previous 6 months to study enrollment, or having received percutaneous electrical stimulation as a treatment before. * cervical pathology, fibromyalgia, unstable cardiovascular diseases, pregnant women or under suspect of pregnancy. * contraindications of needle's insertions: anticoagulant therapy, needle phobia, diabetes, hypothyroidism, lymphoedema, muscular diseases). * contraindications of electrical current application.

Keywords: lateral epicondylalgia lateral epicondylitis lateral elbow tendinopathy lateral elbow pain percutaneous electrical nerve stimulation
effects of cognitive training on academic task performance in attention deficit hyperactivity disorder (adhd)

Conditions: ADHD; Attention

Summary: impaired wm is a central deficit in adhd. a computerized training program, cogmed, has been shown to increase wm capacity in children with adhd. it is not known whether the training improves behavior associated with classroom learning, such as remaining on-task and inhibiting off- task behavior. the aim of this study is to utilize ecologically valid measures to investigate training's effect on observable adhd behavior in conjunction with more standard measures. subjects will be randomly assigned to a cogmed versus an active "placebo" condition in which the tasks do not increase in difficulty level in a double-blinded fashion. the effects of the active cogmed versus placebo computer training will be compared on measures in children with adhd.


Eligibility criteria:
inclusion criteria: 1. age range 7-14 2. at least average academic and intellectual functioning via parent report. 3. must have adhd (by parent report of previous diagnosis or per telephone screening checklist - to be confirmed via interview and ratings) 4. attentional, hyperactive or impulsive symptoms that interfere with functioning. exclusion criteria: 1. diagnosis of severe mental illness for example, psychotic, bipolar or major depressive disorder, (by history) 2. mental retardation (by history) 3. english is not the primary language 4. family does not have a computer

Keywords: cognitive training
characterization of fungal infections in covid-19 infected and mechanically ventilated patients in icu

Conditions: Covid-19

Summary: characterization of fungal infections in covid-19 infected and mechanically ventilated patients in icu

currently, icu patients with ards, whatever the etiology, are not systematically screened for the detection of respiratory fungal infections. here, the protocol will be in two steps: first step covid-19 patients hospitalized in icu for ards will benefit for a systematic screening with a fungal respiratory syndromic panel once or twice a week from entry to discharge from icu, with minimum 3 samples when discharge occurs after 15 days:: * sample: tracheal aspiration, bronchial aspiration, bal * fungal respiratory panel: samples will be processed in each lab for culture without direct examination nor stained smears, and real-time pcr will be performed for aspergillus, pneumocystis jirovecii and mucormycetes * results will be given to icu in order to optimize the management of the patient second step complementary analysis will be performed in order to finalize the diagnostic and to differentiate between colonization and infection, with: * serum detection of galactomannan and serum aspergillus pcr in case of positive respiratory sample for aspergillus * serum/plasma beta-d-glucan detection in case of positive respiratory sample for pneumocystis jirovecii * serum mucorales pcr in case of positive respiratory sample for mucorales this second step is possible in most of the labs, but when necessary a confirmation test can be externalized. a process of dna transmission to a reference lab within each region will be implemented. this second step will allow to classify infections as probable or proven according to international recommendations. case report form (crf) a short but standardized crf will be proposed to all centers in order to collect demographic data and the essential clinical and laboratory data during the survey.

Eligibility criteria:
inclusion criteria : * icu patients covid-19 diagnosed by rt-pcr * intubated and mechanically ventilated patients * adult patients * patients (or legal representative) informed on the research without opposition non-inclusion criteria : * patients \<18 years old * people of full age who are the subject of a judicial safeguard, exclusion criteria: * patient, or legal representative opposing the pursuit of the research * patients under judicial protection will be excluded as soon as the investigator becomes aware of their status.

Keywords: invasives mycoses aspergillosis pneumocystosis mucormycosis
survival in myelofibrosis patients after allogeneic hematopoietic stem cell transplantation in five centers in france

Conditions: Myelofibrosis

Summary: the investigators would like to conduct a retrospective study in five centers in france in the goal to evaluate the survival of patients receiving allogeneic hematopoietic stem cell transplantation for myelofibrosis.

the allogeneic stem cell transplantation is the only curative treatment for myelofibrosis. however, because of complications such as infection, graft-versus-host disease and conditioning toxicity, this procedure is associated with a high morbidity-mortality rate. the discovery of molecular and genetic markers permitted to improve therapeutic strategy and survival of patient in the last few years. in this study, the investigators want to make an overview of survival, incidence of relapse and incidence of acute and chronic graft versus host disease in allogeneic stem cell transplantation for myelofibrosis, in five centers in france, between 2007 and 2017.

Eligibility criteria:
inclusion criteria: adult patients receiving allogeneic hematopoietic stem cell transplantation for myelofibrosis in five centers in france (nancy, besancon, strasbourg, pitie salpetriere and lyon) between 2007 and 2017 - exclusion criteria: * age \< 18 years old

Keywords: allogeneic hematopoietic stem cell transplantation survival graft versus host disease
lat for oligoprogressive nsclc treated with first-line osimertinib

Conditions: Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor

Summary: to determine whether in patients with egfr mutated advanced nsclc and osimertinib as first-line treatment, the (repeated) use of lat to ≤ 3 op lesions and continuation of first-line osimertinib, improves the median progression-free survival by more than 3 months (i.e. pfs2-pfs1 = \>3 months).

the (repeated) use of lat to ≤ 3 op lesions with continuation of first-line osimertinib, is endorsed by international guidelines (nccn, esmo). in this phase iib prospective non-randomized observational trial, we want to document the benefit of lat in this patient cohort.

Eligibility criteria:
inclusion criteria: 1. male or female, ≥ 18 years of age 2. established histological diagnosis of advanced nsclc, not suitable for radical treatment, with an egfr actionable mutation receiving first-line targeted tki therapy with osimertinib 3. initial radiologically confirmed response (at least stable disease) to osimertinib assessed 3 months post commencing osimertinib according to recist criteria v1.1. 4. confirmed opd defined as ≤ 3 intra- and extracranial sites of progressive disease. op may be defined as progression of an individual metastasis according to recist or on 2 consecutive imaging studies at least 2 months apart with a minimum of 5mm increase in size from baseline or an unambiguous development of a new metastatic lesion with a grand total of 3 lesions. all sites must be visible, imaging defined targets, not previously treated with radiation or radiofrequency and suitable for treatment with lat as determined by the local multi-disciplinary team (mdt). 5. adequate baseline organ function to allow lat to all the op targets. 6. predicted life expectancy ≥ 6 months 7. karnofsky index ≥ 60% and ecog 0-2 8. provision of written informed consent 9. female participants must be surgically sterile or postmenopausal if sbrt is planned to the abdominal area or must agree to use effective contraception during the period of therapy. exclusion criteria: 1. \> 3 sites of progressive disease 2. oligoprogressive metastases not amenable to lat 3. radiotherapy or radiofrequency ablation near the op lesion prior to the inclusion in the lat-flosi study 4. co-morbidities considered clinically precluding the safe use of lat 5. any psychological, sociological or geographical issue potentially hampering compliance with the study 6. pregnancy

Keywords: first line osimertinib local ablative therapy
pulsed radiofrequency in trigeminal neuralgia

Conditions: Trigeminal Neuralgia

Summary: the current study investigated the efficacy of pulsed radiofrequency in pain reduction in tn patients and compared the efficacy and the impact on the quality of life of the standard technique with a prolonged duration technique and a higher voltage one. entire enrolled patients were diagnosed as classic tn according to the international headache society classification (ihs, 2013) and underwent brain mri and mra to exclude secondary causes. patients were randomly divided into three groups, group a patients underwent prf using the standard settings, group b patients underwent prf with prolonged duration and group c patients underwent prf with higher voltage. vas and pain amplitude reduction were recorded before the intervention and 1 hour, 1 day, 1week, 1 month, 6 months and 1year after it. quality of life was assessed before and 1 year after the intervention.


Eligibility criteria:
inclusion criteria: * patients are diagnosed as classic tn according to the international headache society classification of headache disorders * visual analogue scale (vas) for pain of at least 4 or more. * pain is refractory to medical treatment (for at least 3 months with three drugs including carbamazepine with optimum dosage) or patients who developed intolerable side effects from medications. exclusion criteria: * symptomatic (secondary) tn: which is causes by structural lesion other than neurovascular compression such as multiple sclerosis, tumors, stroke or trauma according to the international headache society classification (ihs, 2013). local infection at the site of the needle puncture. bleeding tendency or coagulopathy. previous treatment with invasive treatments such as radiofrequency thermo coagulation, destructive chemical injection, gamma knife treatment, percutaneous balloon micro-compression or microvascular decompression. major mental or psychiatric disorders. history of drug abuse.

Keywords: pulsed radiofrequency
intraoperative hypotension and perioperative myocardial injury

Conditions: Myocardial Infarction Postoperative; Myocardial Injury; Intraoperative Complications; Intraoperative Hypotension; Perioperative Complication

Summary: acute myocardial infarction (mi) is a significant complication following non-cardiac surgery. we sought to evaluate incidence of perioperative mi, its preoperative - and intraoperative - risk factors and outcomes after this complication.

background: in sweden, over 800 000 patents undergo surgery each year. worldwide, the number of surgical procedures yearly is over 310 million. surgical care is en essential part of the advancement in treating disease, associated with increased lift expectancy a d improved quality of life. however as surgical volume continues to grow, the number of patients who suffer postoperative complications will also increase. hemodynamic instability in the perioperative period is frequent and there has been a cumulative interest in this area and the relation to organ failure over the recent years. there are several studies showing results of associations between intraoperative hypotensive events and perioperative cardiac, kidney and cerebral injury, as well as increased mortality in high-risk surgical patients. more specifically the project aims to answer how intraoperative events, with a special focus on hypotension, are related to perioperative myocardial and kidney injury. we hypothesize that patients, with preoperative risk factors, undergoing major non-cardiac surgery are at increased risk of developing perioperative organ damage in the presence of intraoperative hypotension or other events such as tachycardia, hypoxia and extensive blood loss.

Eligibility criteria:
cases inclusion criteria: * adults (≥18 years), male and female. * undergoing elective or non-elective in-patients non-cardiac surgery at 3 university hospitals in sweden: karolinska university hospital, skåne university hospital and norrland university hospital. * surgeries performed between 2007 and 2014. * acute myocardial infarction criteria fulfilled within 30 days after surgery. exclusion criteria: * cardiac surgery * obstetric surgery controls: matched (on age, preoperative risk factors, surgical year- site and procedure) surgical patients without myocardial infarction within 30 days after surgery.
biomarkers in prediction of ami

Conditions: Acute Mesenteric Ischemia

Summary: current study will be undertaken to identify combinations of biomarkers that can reliably identify acute mesenteric ischaemia (ami) and distinguish between non-transmural and transmural ischaemia. different combinations of biomarkers for different sub-types and severity of ami, and different time points of measurement after onset of symptoms.


Eligibility criteria:
inclusion criteria: * age 18 years or older * initial decision in favour of further diagnostics of mesenteric ischaemia exclusion criteria: * age \<18 years * consent declined by patient or next of kin (delayed consent) * chronic mesenteric ischaemia without an acute event * immediate decision for withdrawal of further diagnostics and active treatment * referral from another hospital with already established diagnosis of ami * ami diagnosed at surgery without previously having been considered