Kornimate/medical-research-clean huggingface dataset:
mirror therapy for impingement syndrome

Conditions: Impingement Syndrome; Mirror Movements 2

Summary: background: mirror therapy is an adjuvant treatment option based on shoulder impingement syndrome objective:to investigate the effect of mirror theraphy on shoulder impingement syndrome methods: the study included 62 participants, including cases in the intervention group (ig) (± years) and 20 cases in the control group (cg) (years) who met the selection criteria. ig received mirror theraphy with regular physiotherapy while cg received only regular physiotherapy. the patients were evaluated with the before treatment, immediately after treatment (post-treatment).


Eligibility criteria:
inclusion criteria: * being aged 18-75 years * being diagnosed with shoulder impingement syndrome exclusion criteria: * being uncooperative * having an additional systemic disease * having uncontrolled hypertension * presence of heart failure * having hearing or vision problems * having a balance disorder * diagnosis of heart disease and lung disease so advanced that exercise is contraindicated * history of shoulder surgery * have any pathology that may cause referred pain (eg, cervical radiculopathy) * shoulder trauma, previous humeral fracture history * steroid injection to the shoulder joint or subacromial bursa in the last 6 months

Keywords: mirror therapy impingement syndrome shoulder adjuvant treatment
induced myocardial ischemia: a serial troponin t and troponin i measurements

Conditions: Acute Coronary Syndrome; Cardiac Ischemia

Summary: background troponin are proteins found in the cardiomyocyte and are a cornerstone in the diagnoses of acute myocardial infarction. troponin is released to the bloodstream as a result of an cardiomyocyte injury. troponin is frequently assessed in hospital care for patients with chest pain and dyspnea. guidelines recommend troponin assessment at admission and repeated at 3 to 6 hours, depending on the assay. high-sensitivity assays measure concentrations that are ten-times lower than earlier generations of assays. however, the time from when troponin is elevated in the bloodstream after an ischemic injury, measured with high-sensitivity assays, are not fully known. during an x-ray imaging of the heart's blood vessels (coronary angiogram) it is possible to do a short, controlled occlusion of coronary artery by inflating a small balloon in one of the coronary arteries. numerous earlier studies in patients have used this method for induced occlusion of one coronary artery for 1 to 3 minutes. only one of the studies measured troponin i. the aim with this study is to quantify and compare the release of troponin t and troponin i in the early hours after a controlled induced ischemia. study design this is a prospective, descriptive and experimental study. there will be included 40 patients, without acute ischemic cardiac disease. they will be randomized in 4 groups. 0: 10 patients - control group, no balloon occlusion 1. 10 patients - balloon occlusion for 30 seconds 2. 10 patients - balloon occlusion for 60 seconds 3. 10 patients - balloon occlusion for 90 seconds subsequently there will be assessed serial blood samples 0 - 3 hours: every 15 minutes 3 - 6 hours: every 30 minutes statistics this is a pilot study and it is estimated that ten patients are sufficient number of patients in each group to assess elevation of troponin after occlusion of coronary artery. the thesis is there is a dosage-response correlation between the length of balloon occlusion and the concentration of troponin in blood stream.


Eligibility criteria:
inclusion criteria: * \> 18 years of age elective coronary angiogram informed signed accept exclusion criteria: * stenosis or atherosclerosis of the coronary artery renal failure or p-creatinin \> 100 µmol/l heart failure or lvef \< 50 severe heart valve disease
brief mindfulness intervention for chronic pain in ukraine

Conditions: Chronic Pain

Summary: this is a pragmatic randomized controlled trial comparing a single 15-minute mindfulness-based intervention to usual care for patients with chronic pain in ukraine being seen in a pain clinic.


Eligibility criteria:
inclusion criteria: * physician-confirmed chronic pain-related diagnosis exclusion criteria: * cognitive impairment preventing completion of study procedures. * other unstable illness judged by medical staff to interfere with study treatment.
clear corneal incisions and arcuate incisions utilizing femtosecond laser technology for cataract surgery

Conditions: Cataracts

Summary: the purpose of this study is to prove the efficacy and safety of the femtosecond laser to create a clear corneal incision during cataract surgery.


Eligibility criteria:
inclusion criteria: * study participants must have a cataract for which phacoemulsification extraction and posterior iol implantation has been planned in at least one eye. * study participants should be capable of achieving better than 20/30 snellen best corrected distance vision after cataract extraction and iol implantation. * the surgeon may use the mentor potential acuity meter (pam) laser interferometer, mcintyre pinhole, or his/her judgment to estimate the patient's potential acuity. exclusion criteria: * concurrent participation or participation in the last thirty days in any other clinical trial. * known steroid iop responder * taking medications that may affect vision, iop or ease of cataract surgery (e.g., flomax, glaucoma mediations, etc.) * acute or chronic disease or illness that would increase risk or confound study results (e.g., uncontrolled diabetes mellitus, immunocompromised, etc.) * uncontrolled systemic or ocular disease * corneal abnormalities (e.g., stromal, epithelial or endothelial dystrophies) * pseudoexfoliation * ocular hypertension iop \>25 mmhg by tonometry or glaucomatous changes in the optic nerve
optimizing pain management following laparoscopic cholecystectomy rct

Conditions: Acute Post-operative Pain; Cholecystectomy, Laparoscopic; Pain Assessment Pain Intensity; Pain Intensity

Summary: evaluating the two final steps we added to optimize post laparoscopic cholecystectomy pain management.

introduction: after a laparoscopic cholecystectomy (lc), pain is still a significant concern, leading to extended hospital stays or readmissions. in majority of patients, postoperative pain medications are required. a standardized strategy is needed to offer effective pain relief postoperatively. the majority of pain in the early postoperative period is due to elimination of intraperitoneal surface tension or of parietal type. aim of the work: to evaluate the two final steps we added to optimize postoperative pain management. patients and methods: over the period from march 2020 to december 2021, 816 patients with gallbladder stone undergoing lc were randomized into 2 groups after exclusion of 12 patients: group a; interventional contained 402 patients. group b; control contained 402 patients. post-operative data to be compared were made in terms of operative time, shoulder pain, upper abdominal pain, (at 6,12,18 and 24 hours) and number of analgesic doses and hospital stay. pain intensity was assessed by using the visual analogue scale (vas) for each patient.

Eligibility criteria:
inclusion criteria: * patients who were having symptoms consistent with biliary colic, * had ultrasound evidence of gall stones, * classified as american society of anesthesiology (asa) i and ii * ages ranging from 18 to 65 years exclusion criteria: * patients who refused to give consent, * pregnant, * had a history of drug abuse, * had cbd stones, * acute cholecystitis, * acute pancreatitis, * previous abdominal surgery, * history of peritonitis, * had carcinoma of the gall bladder patients who were converted to open surgery, * patients who required placement of drains * patients with intraoperative complications (cbd injury or liver bed bleeding).
comparison of two new generation drug eluting stents in patients with diabetes (oct-des)

Conditions: Coronary Artery Disease; Diabetes

Summary: the aim of this study is a comparative evaluation of re-endothelailisation of the integrity resolute zotarolimus eluting stent (medtronic) and of the promus element erolimus eluting stent (boston scientific), in patients with diabetes. we plan to compare endothelial coverage and neointimal proliferation using oct and compare this data to published results from conventional stents.


Eligibility criteria:
inclusion criteria: * known to have diabetes * scheduled for percutaneous coronary intervention (pci) with a stenosis suitable for des implantation and oct imaging * reference vessel diameter over 2.5mm by operator assessment. * able to understand and sign the written informed consent form. * able and willing to follow the protocol requirements. exclusion criteria: * inability to consent * cardiogenic shock * planned use of a bare metal stent * lms coronary artery disease * congestive cardiac failure or low ejection fraction (lvef \<35%) * lesions unsuitable for oct * total length of stented lesion greater than 55mm (total combination of stent lengths) * age less than 18 years or age greater than 80 years * planned surgical procedure ≤ 12 months post pci procedure * patient demonstrates evidence of thrombocytopenia (platelet count \< 100,000/mm3) * patients with contraindications to asa, clopidogrel, or prasogrel * patient is currently on warfarin, or possibility of treatment with warfarin during the following 12 months post index procedure * allergy to contrast * patients enrolled in another active clinical trial. * potential for non-compliance towards the requirements in the study protocol. * serious known concomitant disease with a life expectancy of less than one year * follow-up impossible (no fixed abode, etc) * patients with renal impairment (creatinine \>200mmol/l) * subjects of childbearing potential

Keywords: diabetes mellitus pci drug eluting stent oct
atorvastatin for the treatment of retinal vein occlusion

Conditions: Retinal Vein Occlusion; Retinal Vein Thrombosis; Central Retinal Vein Occlusion; Branch Retinal Vein Occlusion; Thrombosis

Summary: the atorvo study is designed to determine whether atorvastatin (lipitor) can improve vision, when compared to placebo

retinal vein occlusion (rvo), a common cause of visual loss in the western world, is a disease whose etiology resembles that of classic atherosclerosis. a therapy that lowers the risk of arterial and venous thrombosis would seem to be a reasonable approach to managing this disease, for which there is currently no treatment. atorvo is a randomized double-masked clinical trial comparing a daily dose of 80 mg of atorvastatin to matched placebo in persons recently diagnosed with rvo. at 24 weeks after randomization, we will evaluate each participant's visual acuity and the presence of secondary complications related to rvo.

Eligibility criteria:
inclusion criteria: * adults aged 40 years and older * diagnosed with crvo or brvo * visual acuity of 20/40 or worse in the affected eye * onset of current symptoms of loss of vision within the past 60 days * ability to understand spoken english exclusion criteria: * current use of a statin or fibrate medication * known cardiovascular disease or revascularization, including coronary artery disease (myocardial infarction or angina), stroke or peripheral artery occlusion * known diabetes mellitus * known liver disease * serum low-density lipoprotein cholesterol (ldl-c) \> 5.0 mmol/l * baseline serum triglycerides \> 6.0 mmol/l * serum alt above 115 u/l (i.e., 2.5 x upper limit of normal) * baseline serum creatinine \> 250 µmol/l * ocular surgery within the past 90 days * planned ocular or cataract surgery within the study period * known retinal disease: age-related macular degeneration, retinal detachment or macular hole, or past history of vein occlusion * women who are pregnant or who are breastfeeding * participation in another clinical trial concurrently or within 30 days prior to screening * known allergy to fluorescein dye * current use of cyclosporine medication. * current use of an hiv protease inhibitor medication.

Keywords: retinal vein occlusion retinal vein thrombosis central retinal vein occlusion branch retinal vein occlusion visual loss atorvastatin statin neovascularization thrombosis
comparison of effect of virtual reality and kinetic chain exercises in knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: it is necessary to explore the novel rehabilitation strategies to treat knee osteoarthritis. although kinetic chain exercises have shown efficacy but there is growing interest in virtual reality training using xbox kinect because it has the potential to enhance motivation and patient's adherence to rehabilitation. the aim of this study is to compare the effectiveness of both interventions and provide a valuable insight to optimize the therapeutic strategies for treating knee osteoarthritis.

knee osteoarthritis (oa) is a prevalent musculoskeletal condition that impacts the quality of life. despite various treatment options, managing knee oa is still a challenge for healthcare professionals. however, there is growing interest in exploring the innovative interventions to decrease symptoms and improve functional outcome in patients with knee oa.the project will be a randomized control trial conducted to check the effect of virtual reality and kinetic chain exercises in patients with knee osteoarthritis.so that we can have best treatment option. duration of this study will be of 8 weeks , convenient sampling will be done, subjects following eligibility criteria from iimct pakistan railway general hospital will be randomly allocated in two groups, baseline assessment will be done, group a will be given xbox kinetic training and group b will be given kinetic chain exercises . outcome measures if this research will be pain , range if motion , function and disability. post intervention assessment will be done via nprs , womac , koos_ps and goniometric measurements of knee ranges .data was analyzed by using spss software. there is lack of research comparing the effectiveness of virtual reality xbox kinect and kinetic chain exercises in patients with knee osteoarthritis. there are studies that have explored the effectiveness of these interventions separately. in past, few researches support the fact that virtual reality rehabilitation is more effective than conventional physical therapy and few researches are in support of kinetic chain exercises being more effective for knee osteoarthritis. however there is no study that has compared these both interventions. therefore there is a need for further research to compare both of these interventions which in future will provide optimal, more personalized and effective rehabilitation strategy for individuals with knee osteoarthritis

Eligibility criteria:
inclusion criteria: * both male \& female * age 50 or older. * body mass index (bmi) between 18.9kg/m2 and 29.9 kg/m2. * diagnosed with grade ii knee oa * have knee pain \> 4 on nprs * ability to engage in moderate physical activity. exclusion criteria: * severe comorbidities limiting physical activity. * history of hip and knee arthroplasty. * cognitive impairments affecting comprehension

Keywords: knee osteoarthritis xbox kinetic virtual reality rehabilitation kinetic chain exercises
a clinical pharmacology study of mt-2990 in seasonal allergic rhinitis patients

Conditions: Seasonal Allergic Rhinitis

Summary: the objective of this study is to investigate the safety, tolerability, and pharmacokinetics of mt-2990 in patients with japanese cedar pollen-induced seasonal allergic rhinitis (jc-sar). additional objective of the study is to investigate the efficacy and pharmacodynamics profile of mt-2990 in an environmental exposure chamber (eec) on day 8, 29, 57, and 85.


Eligibility criteria:
inclusion criteria: * a body weight of 40 to 100 kg for female or 45 to 100 kg for male * a body mass index of 18 to 30 kg/m2 * subjects who have current history of jc-sar in previous 2 consecutive years. * presence (cap-rast: ≥2) of ige specific to japanese cedar pollens and absence (cap-rast: ≤1) of ige specific to other 4 allergens * presence of at least 2 symptoms, which are moderate to very severe, in 4 nasal symptoms (runny nose, sneezing, blocked nose, itchy nose) at any time point during allergen exposure in eec at screening period exclusion criteria: * presence of any symptoms of allergic rhinitis within 1 year except scattering season of cedar pollen or cypress pollen * subjects who have persistent symptom caused by allergen exposure in eec at screening period until day 1 (pre-dose) * underwent nasal surgery (include laser surgery) to improve nasal symptoms within 2 years * underwent specific immunotherapy or non-specific immunotherapy within 5 years * underwent medication of anti-histamine, oral mast cell stabilizer, leukotriene receptor antagonist, prostaglandin d2/thromboxane a2 receptor antagonist, th2 cytokine inhibitor, corticosteroid (oral form, intra-nasal form, ocular form), or vasoconstrictor within 4 weeks * underwent medication of corticosteroid (injection form) or anti-ige antibody within 6 months * subject who is concerned about exacerbation of the physical condition due to allergen exposure in eec
different local anesthetic volumes for tpvb in post-thoracotomy analgesia

Conditions: Thoracic Paravertebral Block; Thoracotomy; Postoperative Analgesia; Acute Pain; Local Anesthetic

Summary: thoracotomy is one of the most painful operations known. therefore, it causes severe acute pain. if pain is not controlled, it increases the frequency of postoperative pulmonary complications and postoperative morbidity. it can even cause chronic pain in the future. thoracic epidural analgesia (tea) is the gold standard method in the treatment of pain after thoracotomy. thoracic paravertebral block (tpvb) is known as the most effective method after tea. the fact that tpvb has fewer side effects than tea increases the use of tpvb. there is no consensus on the dose of analgesia in studies. in the literature, volumes between 20 ml and 30 ml are frequently used for tpvb in recent years. this study, it was aimed to compare the efficacy of 20 ml, 25 ml, and 30 ml volumes of tpvb with local anesthetic at the same concentration (0.25% bupivacaine) on postoperative analgesia in patients undergoing thoracotomy.


Eligibility criteria:
inclusion criteria: * 18 to 80 years old * american society of anesthesiologists (asa) physical status i-ii-iii * bmi 18 to 40 kg/m2 * elective thoracotomy surgery exclusion criteria: * patient refusing the procedure * emergency surgery * history of chronic opioid or analgesic used
bip cvc in access center at danderyd hospital, stockholm, sweden

Conditions: Vascular Access Complication; Catheter-Related Infections; Catheter Thrombosis; Catheter Blockage; Catheter Complications; Catheter Site Discomfort; Catheter Bacteraemia

Summary: primary objective of the study is to establish the incidence of all any catheter related complications in bip cvc and standard cvc groups in patients requiring cvc. (cvc - central venous catheter; bip - bactiguard infection protection)

catheter related complications include crbsi, cri, local cvc infection, need to exchange of cvc due to suspected cri/crbsi or thrombosis, stop / slower flow in any cvc lumen, local thrombosis, device malfunctions / technical catheter problems, device related adverse events. (crbsi - catheter related blood stream infection; cri - catheter related infection)

Eligibility criteria:
inclusion criteria: 1. patients admitted to the access center at danderyd who need an elective cvc (surgery, infection, nutrition, medication...) 2. fully recognize and understand patient information 3. signed informed consent exclusion criteria: 1. if cvc present prior to inclusion in the study and no intention to change the present cvc over guidewire 2. age \< 18 years 3. pregnant women 4. known allergy to gold, silver and palladium 5. participation in other clinical studies which may interfere with this study as judged by the investigator
isolated oligohydramnios less favorable delivery and neonatal outcomes

Conditions: Oligohydramnios, Delivered

Summary: oligohydramnios happens in 1-5% of term pregnancies. the clinical significance of isolated oligohydramnios been a matter of debate. we aimed in this study to investigate the impact of isolated oligohydramnios on the mode of delivery and risk of adverse perinatal outcome.

retrospective study conducted in armed forces hospitals of southern region, comparing cases with oligohydramnios (amniotic fluid level index \<5) to normal amniotic fluid cases (amniotic fluid level index ≥ 8). primary outcomes are the mode of delivery and adverse perinatal outcomes (including mortality, nicu admission, low apgar score and sepsis)

Eligibility criteria:
inclusion criteria: 1. third trimester pregnancy 2. isolated oligohydramnios exclusion criteria: 1. multiple pregnancy 2. less than 32 weeks 3. medical disorders like dm hpn 4. fetal jeopardy
efficacy of hypnosis during embryo transfer procedure on clinical pregnancy rate for patients undergoing assisted reproductive technology ivf or icsi

Conditions: Infertility

Summary: the purpose of this study is to compare the clinical benefits that can be expected by the embryo transfert procedure with hypnosis to the usual embryo transfer procedure


Eligibility criteria:
inclusion criteria: consent to participate in study age ≥ 18 years and \< 41 years ivf or ivf/icsi attempt gnrh antagonist or agonist stimulation protocol scheduled transfer of 1 or 2 embryos exclusion criteria: refusal to provide consent refusal hypnosis fsh \> 13 muiml cfa \< 8 follicles amh \< 0.5 ngml patient not covered by the social security system (nhs)

Keywords: hypnosis embryo transfer ivf icsi
pulmonary hypertension: efficacy of a 3 week inpatient rehabilitation on physical condition, body composition and health related quality of life

Conditions: Pulmonary Hypertension: Efficacy of Rehabilitation

Summary: pulmonary hypertension (ph) leads to impaired physical condition (pc), body composition (bc) and health-related quality of life (hrqol). we hypothesized that a 3 week inpatient pulmonary rehabilitation (pr) improves pc, bc and hrqol.

pulmonary hypertension (ph) impairs physical condition (pc), body composition (bc) and health-related quality of life (hrqol). specific pharmacological treatment and - in selected patients, refractory to agents - lung or combined heart and lung transplantation can improve physical functioning and long term survival. initial trials with limited numbers of patients were encouraging. investigation of larger cohorts is essential to assess the efficacy of rehabilitation programmes in ph. we hypothesize that a 3 week inpatient pulmonary rehabilitation (pr) improves pc, bc and hrqol in patients with ph in functional classes (fc) ii and iii. critical ill patients with a functional class iv are excluded. all patients with ph undergo a 3-week inpatient rehabilitation program (interval bicycle and strength training, physiotherapy, psychological support, education). exercise testing (peak work load (pwl) 6-min-walk distance), body composition (bioimpedance analysis bia: lean body mass (lbm), body cell mass (bcm), bcm/lbm ratio, phase angle (pa)) and hrqol (sf 36 questionnaire) are assessed at baseline and completion of pr.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of pulmonary hypertension * functional class ii-iii exclusion criteria: * functional class i and iv * right heart decompensation

Keywords: pulmonary hypertension rehabilitation exercise capacity body composition health related quality of life