Kornimate/medical-research-clean huggingface dataset:
comparison of the effects of aerobic exercise and computerized cognitive stimulation in patients with schizophrenia - a randomized controlled trial

Conditions: Schizophrenia; Exercise; Computerized Cognitive Stimulation

Summary: schizophrenia is a chronic mental disorder characterized by the occurrence of both positive symptoms, such as hallucinations and delusions, and negative symptoms, such as apathy and withdrawal, repetition of cognitive skills and disorganization. there are approximately 20 million people with schizophrenia worldwide and this number will continue to increase every year.

the aim of this study was to compare the effects of computer-based cognitive stimulation and aerobic/strengthening exercises on cognition, physical capacity, depression, quality of life, quality of life, and activities of daily living in schizophrenia patients receiving community mental health center services.

Eligibility criteria:
inclusion criteria: * individuals diagnosed with schizophrenia by a physician according to dsm-v criteria patients treated at trsm individuals diagnosed with schizophrenia between the ages of 20-60 exclusion criteria: * those who did not give consent to participate in the study patients with a diagnosis other than schizophrenia pregnancy patients with chronic metabolic diseases such as diabetes, heart problems and cancer
isovolumetric and isocaloric preloads of various types of milk on food intake, subjective appetite and glycemic response

Conditions: Diabetes Prevention; Obesity Prevention

Summary: the purpose of this protocol is to study the effects of fluid milk products on satiety, food intake, and glucose metabolism in healthy young men and women. experiment 1: the specific objective is to investigate isovolumetric amounts of milk (2% m.f.), chocolate milk (1% m.f.), a soy beverage, cow's milk-based infant formula, and water (control) on satiety and food intake and on blood glucose before and after a meal. a fixed volume approach is based on the commercially available serving size. experiment 2 will examine equicaloric amounts of milk (2% m.f.), chocolate milk (1% m.f.), a soy beverage, cow's milk-based infant formula, a glucose drink and water (control) the treatments in order to investigate macronutrient composition on satiety and food intake and on blood glucose before and after the meal.


Eligibility criteria:
inclusion criteria: * healthy * non-smoking * aged 20-30 years * body mass index between 20 and 24.9 kg/m2 exclusion criteria: * diabetes * medication * lactose-intolerance or allergies to milk * breakfast skippers and those on an energy restricted diet

Keywords: food intake blood glucose milk
clinical outcome of autonomous cortisol secretion in adrenal incidentalomas

Conditions: Adrenal Incidentaloma

Summary: the primary aim of the study is to assess mortality and cardiovascular events potentially linked to cortisol excess in patients with adrenal incidentalomas stratified by cortisol values following the 1-mg overnight dexamethasone test.

the napaca outcome study is part of the ensat registry (https://registry.ensat.org/)

Eligibility criteria:
inclusion criteria: * age ≥18 years * adrenal incidentaloma (≥ 1cm) detected by cross-sectional imaging between january 1, 1996 and december 31, 2015 * imaging characteristics suggestive for an adrenal adenoma or excluded malignancy by follow-up imaging * availability of a 1 mg dexamethasone test result * follow-up data on living status and occurrence of cardiovascular events * follow-up duration of at least 36 months. exclusion criteria: * proven pheochromocytoma, primary hyperaldosteronism or adrenocorticotropic hormone (acth)-dependent cushing's syndrome * clinical features suggestive for overt cushing's syndrome; urinary free cortisol (ufc) ≥ 2-fold higher than the upper limit of normal of the local assay * any active malignancy (including adrenocortical cancer) at the time of primary diagnosis
pocket-sized ultrasound for point-of-care diagnosis of heart failure

Conditions: Heart Failure, Congestive; Cardiac Failure

Summary: assessment of pocket sized ultrasound (vscan ge healthcare) for diagnosing heart failure in primary care patients, with a comprehensive cardiac ultrasound examination (siemens acusan p10) performed at a specialized the eco.lab, as reference.

waiting times for cardiac ultrasound is a cause of delay in identification of heart failure, which means delayed treatment, or that treatment recommendations are based on insufficient knowledge. heart failure is a common condition; about 10% of 80-year-old people are affected and most patients are treated within primary care. a new ultrasound technology with integrated software support for interpretation (pocket-sized ultrasound) promises to improve care for heart patients and lead to earlier treatment with effective drugs. in cooperation with norwegian researchers and the region of jämtland härjedalen, this project opens opportunities for a significant medical innovation. the new concept, pocket-sized ultrasound for diagnosis of heart failure, has not previously been validated in patients seen in primary care. a new study may provide very important information that is directly applicable in the care of heart failure patients. we aim to recruit 250 study patients from the waiting list of patients referred from gps, to ultrasound at the dpt. of clinical physiology, östersund hospital, due to a suspicion of heart failure. the examinations will be carried out during the same day, with the investigators blinded to each other. the new concept of ultrasound has a potential to provide more cost-effective identification and monitoring of patients with heart failure in primary care.

Eligibility criteria:
inclusion criteria: study patients fulfil all of the following criteria: 1. age 20 and over 2. recruited from primary care clinics, in the region of jämtland härjedalen, sweden. 3. referred to comprehensive cardiac ultrasound (reference method) from gps, due to suspected heart failure. 4. provide written informed consent before enrolment. exclusion criteria: 1. non consenting patients. 2. patients in need of acute medical attention.

Keywords: diagnostic ultrasound primary care
european study of hf0220 in mild to moderate alzheimer's disease patients

Conditions: Alzheimer's Disease

Summary: the purpose of this phase ii study is to evaluate the safety and tolerability of hf 0220 in patients with alzheimer's disease compared to placebo (inactive substance). the study will also validate biochemical markers as appropriate clinical end-points and to assess the suitability of chosen dose levels for future clinical studies.


Eligibility criteria:
recruitment of participants is performed only by study sites inclusion criteria: participants must meet the following inclusion criteria to be eligible. * male or female (age over 55 years). females must be non-child-bearing potential. male patients with female partners of child-bearing potential should use effective contraception for the duration of the study. * a diagnosis of probable alzheimer's disease established in accordance with the national institute of neurological and communicative disorders and stroke /alzheimer's disease and related disorders association (nincds-adrda) classification. * severity of dementia of mild to moderate as assessed by the mini-mental state examination (mmse) score of 12-24. * patients must be living in the community living with or have at least daily visits from a responsible carer. the carer should be capable of assisting with the patient's medication, and prepared to attend with the patient for assessment. * written consent should be obtained from the patient and responsible carer. exclusion criteria patients will not be eligible to participate in the study if they meet any of the following criteria: * primary, secondary or pseudodementias other than probable alzheimer's disease. * clinically significant and/or uncontrolled condition or other significant medical disease. * if taking medication for symptoms of dementia, the patient must be stable on therapy and have been taking these for a minimum of 3 months prior to enrolment. * treatment within the previous 3 months with any drug known to have a well defined potential for hepatotoxicity. * non-steroidal or steroidal anti-inflammatory agents. however, patients stable on low dose aspirin (upto 300mg/day) for at least 3 month prior to enrolment will be eligible. * taking anti-oxidant supplements. * active smokers of tobacco. * considered to be malnourished (body mass index \<19). * patients in whom a lumbar puncture is contra-indicated.

Keywords: alzheimer's disease
exercise is medicine: a cohort study

Conditions: Hypertension

Summary: 6,000 patients with ht and/or dm will be recruited to participate a 12-week eim exercise intervention, which also involve consistent feedback and reminders using information technology (it). the primary outcome will be improvement of blood pressure at 1-year. other clinical outcomes will be obtained on recruitment (baseline), 12-week (immediately after eim classes) and 1-year after recruitment


Eligibility criteria:
inclusion criteria: * have a clinical diagnosis of primary ht and/or type ii dm from clinical medical record * having less than 150 minutes of moderate intensity exercise per week or having less than 75 minutes of intensive intensity exercise per week (this is set according to latest world health organization guideline) * who have used any mobile apps on their phone (because the intervention involve use of apps to monitor and remind regular exercise) exclusion criteria: * patients with diagnosed chronic obstructive lung disease and recent stroke (within last 12 months) * patients on 3 or more anti-hypertensive medications (on maximum or maximal tolerable doses) are excluded because these patients have resistant ht and may represent another spectrum of disease. * patients with spinal cord compression, radiculopathy with active pain, or osteoarthritis of hips and knees that are on the waiting list for joint replacement surgery are excluded for safety reasons. * acute myocardial infarction in last 6 months * ongoing angina * uncontrolled cardiac arrhythmia * acute diseases including known active endocarditis/acute pulmonary embolism, pulmonary infarction, deep vein thrombosis, acute aortic dissection, acute myocarditis * known aortic stenosis * known heart failure * known obstructive left main coronary artery stenosis * uncontrolled ventricular rates * complete heart block * known hypertrophic obstructive cardiomyopathy * mental impairment that limit co-operation * resting blood pressure with systolic blood pressure \>180mmhg or diastolic blood pressure \>110mmhg * known anaemia with haemoglobin level less than 11gm/dl * known uncorrected electrolyte imbalance * known uncontrolled hyperthyroidism. * for dm patients, patients with proliferative diabetic retinopathy and recent retinal bleeding (in last 12 months)
effects of mdrt vs cee on pulmonary functions, chest expansion and asthma control in asthma patients

Conditions: Asthma

Summary: to determine the effects of manual diaphragmatic release technique (mdrt) versus chest wall expansion exercises on pulmonary function, chest wall expansion and asthma control in patients with asthma.

patients who will meet the inclusion criteria will be recruited by convenient sampling technique and allocated to groups by simple randomization process by sealed opaque enveloped labeled as a for group a and b for group b. at the beginning of the study, a formal educational session, lasting about 30 minutes will be given by the physiotherapist dealing with the treatment/interventions. group a: it will receive mdrt and generalized body stretching. group b: it will receive chest expansion exercises and generalized body stretching. frequency of patient's visit will be tailored with minimum of 2-3 visits per week for 4 weeks.

Eligibility criteria:
inclusion criteria: * • medically diagnosed asthma patients. * aged 35-60 years. * patient should be non-smoker or ex-smoker for last 6 months exclusion criteria: * • patients having other cardiac or respiratory diseases. * patient having thoracic or abdominal surgeries. * pregnancy and uncontrolled hemodynamic parameters. * inability of patient to understand instruction due to mental disorder.

Keywords: manual diaphragmatic release technique chest wall expansion exercises pulmonary functions chest expansion asthma control dyspnea
plan and pledge, hiv self-testing in south africa

Conditions: Human Immunodeficiency Virus

Summary: the plan and pledge pilot will incorporate behavioral economics approaches (nudges) into the pre-existing star self-test fixed-site distribution program, implemented by wits reproductive health and hiv institute (wits rhi) at the university of witwatersrand, johannesburg, south africa. the objective of this pilot is to examine the use of commitment strategies to increase uptake of hiv self-testing in south africa.

this study will use a cluster randomized trial design to test the effectiveness of interventions designed to increase usage of self-test and reporting of results by hiv self-tests recipients. specifically, this study will examine the use of commitment and planning prompts to increase the uptake of hiv self-testing in the tshwane district in south africa. the intervention will build on the implementation procedures of star program (hiv self-testing africa). the two arms in the study will be: 1) usual care, "promote": a card with information to report results via whatsapp, similar to the existing card used in the star program. with a dedicated usual care whatsapp number (different from the existing campaign numbers). 2) plan and pledge: a card with the information from the usual care card plus a brief template to "make a plan" and "make a pledge" for test completion and results reporting, to take the test. the card will include a dedicated pledge and plan whatsapp number. self-test distribution team-day pair will serve as the unit of randomization (i.e. two pairs of star field staff will be randomized by arm and by day. clusters of individuals will receive self-tests at a distribution site from a pair of star field staff on an individual day). computer-generated randomization will be used to assign site-day clusters to the 2 study arms. the study will take place at the star community fixed-point distribution sites in tshwane district, south africa.

Eligibility criteria:
inclusion criteria: * 19 years of age or older exclusion criteria: * intoxication as this effects the result of the hiv self-test
hpv-based screen-and-treat demonstration project in lilongwe

Conditions: HPV Infection; Cervical Cancer; HIV Infections

Summary: the purpose of this study is to assess completion and performance of the following novel invasive cervical cancer (icc) screen-and-treat algorithm among 625 hiv-positive women in lilongwe, malawi: 1) rapid testing of self-collected vaginal brush for primary high risk (hr)-human papillomavirus (hpv), 2) same-day visual inspection with acetic acid (via) for women who are hr-hpv positive, and 3) thermocoagulation for via positive/ablation-eligible (by cervical colposcopy) women.

this is a single arm, prospective study of 625 hiv-positive women attending art clinics in lilongwe, malawi. the primary objectives of this study are to assess completion of a novel icc screen-and-treat strategy among hiv-positive women in lilongwe, malawi, using self-collected vaginal brush for hr-hpv testing, followed by same-day via and thermocoagulation for hpv-positive/via-positive/ablation-eligible (by colposcopy) women, and to determine the 24-week efficacy of thermocoagulation among hiv-positive women with cin2/3. the secondary objective will be to evaluate the performance of the icc screen-and-treat strategy by estimating overtreatment for women who are hpv-positive/via-positive/ablation-eligible, and undertreatment among hpv-positive/via-negative women.

Eligibility criteria:
inclusion criteria: 1. females ≥ 25 years of age at study entry and ≤ 50 years of age (per current malawi national cervical cancer control program guidelines for screening). 2. females with confirmed hiv-1 infection. fda-approved testing methods should be used when possible. 3. ability and willingness of participant to provide written informed consent. exclusion criteria: 1. current or prior history of cervical, vaginal or vulvar cancer or dysplasia 2. current symptomatic sexual transmitted infection requiring treatment (women will be allowed to be in the study upon successful treatment) 3. prior hpv vaccination. 4. participants with known allergy to acetic acid. 5. participants with a history of total hysterectomy. 6. participants who are pregnant or plan on becoming pregnant during the study period. 7. participants who are less than 12 weeks postpartum. 8. participants with other illnesses that would limit compliance with study requirements or in the opinion of the investigator or designee, have a problem that would make participation in the study unsafe or complicate interpretation of study findings.

Keywords: visual inspection with acetic acid (via)
the effect of specific strength-training on tension-type headache in children 9-17 years

Conditions: Tension-Type Headache

Summary: this study aims at examining muscle strength capacity in neck and shoulder muscles in children and adolescents with and without tension-type headache, and furthermore examining the effect of a 10 week specific strength training programme for neck and shoulder muscles compared to a multi-disciplinary approach in 10 weeks.

frequent and chronic tension type headache are the most frequent pain illnesses in children with a prevalence of 0.5-7,6%. frequent or daily headache leads to constraints in the child's life in relation to school and social activities. the underlying pathophysiological mechanisms are not yet fully examined. in several studies in adults and in children it is found that the shoulder muscles are tense and tender, but it is not known whether this phenomenon is primary or secondary to tension-type headache. a decrease in muscle capacity is furthermore found in studies. we therefore aim at examining parameters for muscle function in order to compare the differences between children with and without headache, and at examining the effect of a 10 week progressive specific strength training programme on headache compared to an in time comparable multidisciplinary intervention based on lifestyle counseling.

Eligibility criteria:
inclusion criteria: * primary tension-type headache with no more than one episode of migraine pr. month exclusion criteria: * post-trauma headache * co-morbidity

Keywords: tension-type headache strength capacity neck and shoulder
maintenance treatment of renal anemia in dialysis subjects

Conditions: Anemia; Renal Insufficiency, Chronic

Summary: the purpose of this study is to evaluate the efficacy and safety of molidustat in comparison to darbepoetin alfa in dialysis subjects with renal anemia who are treated with erythropoiesis-stimulating agents (esas).


Eligibility criteria:
inclusion criteria: * subject with eskd (end-stage kidney disease) on regular dialysis (including, hemodiafiltration, hemofiltration, hemodialysis, and other modalities except for peritoneal dialysis) weekly or more than weekly for at least 12 weeks prior to randomization * body weight (after dialysis) \> 40 and ≤ 160 kg at screening * male or female subject ≥ 20 years of age at screening * at least one kidney * treated with weekly or bi-weekly dose of darbepoetin alfa, monthly or bi-weekly dose of epoetin beta pegol, or weekly, biweekly, twice or three times per week dose of epoetin alfa/beta, and having had no more than one dose change within 8 weeks prior to randomization * mean screening hb level ≥ 9.5 and \< 12.0 g/dl (mean of all central laboratory hb levels before dialysis \[at least 2 measurements must be taken ≥ 2 days apart\] during the screening period, and all hb level must be measured by the central laboratory, and the difference between the lowest level and highest level is \< 1.2 g/dl), with the last screening hb level measurement within 14 days prior to randomization * ferritin ≥ 100 ng/ml or transferrin saturation ≥ 20% at screening * serum folate level and serum vitamin b12 level above lower limit of normal (lln) at screening exclusion criteria: * new york heart association (nyha) class iii or iv congestive heart failure * history of cardio- (cerebro-) vascular events (e.g., unstable angina, myocardial infarction, stroke, pulmonary thromboembolism, and acute limb ischemia) within 6 months prior to randomization * sustained, poorly controlled arterial hypertension (defined as systolic bp (blood pressure) ≥ 180mmhg or diastolic bp ≥ 110mmhg) or hypotension (defined as systolic bp \< 90mmhg) at randomization * proliferative choroidal or retinal disease, such as neovascular agerelated macular degeneration or proliferative diabetic retinopathy requiring invasive treatment (e.g., intraocular injections or laser photocoagulation) at screening
diosmin as adjuvant therapy in treatment of non-bleeding peptic ulcer

Conditions: Non-bleeding Peptic Ulcer

Summary: the aim of the study is to evaluate the safety and efficacy of diosmin as adjuvant therapy in treatment of non-bleeding peptic ulcer patients.


Eligibility criteria:
inclusion criteria: -. age 25-65 years old. * patients of both gender (male and female). * non-bleeding peptic ulcer patients (duodenal \&gastric) diagnosed by endoscopy. exclusion criteria: * the presence of other factors that can lead to gastric bleeding other than peptic ulcer. * patients with cancerous disease * breast-feeding. * surgically altered stomach ( bariatric surgery), * patient with liver disease. * bleeding \& perforated peptic ulcer.
the analysis of hair count in healthy taiwanese persons by trichoscope

Conditions: Dermatosis

Summary: horizontal sectioning of scalp biopsy is a better method for evaluating hair disorders than vertical sectioning because it enables the quantitative examination of hair follicles at different stages. without having the quantitative data of normal scalp hair counts as controls, it is impossible to evaluate scalp biopsies for hair disorders. in recent years, trichoscope is more popular in analysis of hair disease. it is less invasive and simple. the aim of this study is to understand the pros and cons of trichoscpoe.


Eligibility criteria:
inclusion criteria: * 20-50y/o adults without any scalp disorder exclusion criteria: * adults with any scalp disorder