Kornimate/medical-research-clean huggingface dataset:
cognitive function and body mass index in children and adolescents

Conditions: Obesity, Childhood; Obesity, Adolescent; Cognitive Orientation

Summary: the child will complete computerized tasks and paper-pencil test, and will be presented with symbols, letters, or numbers on a computer screen and asked to respond by pressing a button on the computer. before each task a researcher will explain the instructions of the task and assess if the child needs a break before completing the next task. while the child is completing computerized tasks, the parent/guardian will be asked to fill out paper-pencil questionnaires about the child and to sign a release of medical information form so that we can study how physical markers of health effect cognition.


Eligibility criteria:
inclusion criteria: * local population (based on ethnicity) * healthy or overweight/obese exclusion criteria: * history of developmental delay or disorders * history of any medical conditions ( that may impact the development)
assessing the safety and performance of the easyendotm universal linear cutting stapler in laparoscopic gastric bypass surgery

Conditions: Roux-en-Y Gastric Bypass; Obesity

Summary: the purpose of this observational registry is to evaluate the safety and performance of the easyendotm universal linear cutting stapler and reloads from ezisurg medical used in laparoscopic rygb surgery to create anastomoses. the goal of the study will be achieved by assessing the device performance and reporting of peri- and postoperative complications in a prospectively maintained database.


Eligibility criteria:
inclusion criteria: 1. age at study entry is at least 18 years. 2. patient must sign and date the informed consent form prior to the index-procedure. if the patient is not able to give informed consent, a legally authorized representative must give informed consent on his/her behalf. 3. patient has a bmi ≥ 35 kg/m2 with one of more related co-morbidities. 4. patient has a bmi ≥ 40 kg/m2. exclusion criteria: 1. patient is pregnant. 2. history of bariatric surgery. 3. patient is known to be, or suspected of being unable to comply with the study protocol or proposed follow-up visits (e.g. no permanent address, known to be non-compliant or presenting an unstable psychiatric history).
does pregnancy increase risk of ventral hernia recurrence?

Conditions: Recurrent Hernia of Anterior Abdominal Wall

Summary: the investigators will examine if pregnancy increases risk of ventral hernia recurrence

the investigators will establish a cohort of female fertile patients who underwent ventral hernia repair (umbilical, epigastric and incisional hernia repair) registered in the danish hernia database. the investigators will link these data at an individual level with the danish national patient registry (dnpr), danish medical birth registry (dmbr) and the danish civil registry (cpr). from dmbr, subsequent pregnancies in the study cohort will be noted. from dnpr, ventral hernia recurrence, defined as clinical recurrence and/or reoperation for recurrence will be noted. cases registered with both clinical recurrence and reoperation for recurrence, the date of the earliest registration will be defined as the date of ventral hernia recurrence. from cpr, date of death or emigration will be noted. through an extended cox regression analysis, handling pregnancy as a time-dependent variable, the investigators will examine whether pregnancy is associated with an increased risk of ventral hernia recurrence.

Eligibility criteria:
inclusion criteria: * fertile female patient exclusion criteria: * non-danish citizen
preventing epilepsy using vigabatrin in infants with tuberous sclerosis complex

Conditions: Tuberous Sclerosis Complex

Summary: study design is a phase iib prospective multi-center, randomized, placebo-controlled, double-blind clinical trial. the goal will be to enroll 80 infants with tuberous sclerosis complex who are less than 6 months of age prior to the onset of their first seizure

the central hypothesis of this phase iib trial is that early identification of electroencephalography (eeg) biomarkers and early treatment versus delayed treatment with vigabatrin in infants with tuberous sclerosis complex (tsc) will have a positive impact on developmental outcomes at 24 months of age. it would also prevent or lower the risk of developing infantile spasms and refractory seizures. this preventative approach would be expected to result in more favorable long-term cognitive, behavioral, developmental and psychiatric outcomes and significantly improve overall quality of life. it is a randomized, double-blind, placebo-controlled clinical trial design. successful completion of this trial will also advance the field by demonstrating the value of systematic surveillance with eeg in asymptomatic infants with tsc.

Eligibility criteria:
inclusion criteria: 1. less than or equal to 6 months of age 2. no history of seizures or infantile spasms, or evidence of subclinical electrographic seizures on a previous video eeg 3. meet genetic or clinical diagnostic criteria for tsc, the latter based on current recommendations for diagnostic evaluation, such as physical exam, neuroimaging, echocardiogram exclusion criteria: 1. is greater than 6 months of age 2. has not been diagnosed with tsc 3. history of seizures or infantile spasms, or evidence of subclinical electrographic seizures on a previous video eeg 4. has received any anticonvulsant medication including vigabatrin, other anti-seizure therapeutic agent including cannabidiol 5. has received an oral mtor inhibitor such as everolimus or sirolimus 6. has taken an investigational drug, including but not limited to cannabidiol, as part of a research study 30 days prior to enrollment, or plans on taking an investigational drug at any time during the duration of the study 7. is currently enrolled, or plans on enrolling at any time during the duration of the study, in an experimental behavioral early intervention study 8. has a history of being born prematurely (born less than \<30 weeks gestation at the time of delivery)
salivary calcium in post-menopausal women and prevalence of dental caries

Conditions: Salivary Calcium

Summary: different phases of a woman's life are puberty, menses, pregnancy, and menopause. menopause is one of the normal developmental stages in a woman's life, marks the permanent cessation of menstruation. it occurs due to irreversible changes in the hormones.the gradual variation and circulating sex hormones affect women's psychological balance and quality of life. the hormonal changes affect the reproductory system and affect the bone integrity and overall health of the individual. the only source of oocytes in women is an ovary. that is the primary source of oestrogens and progesterone, majorly the androgens. therefore, various systemic health concerns like vasomotor symptoms, cardiovascular diseases, cancer, sexual problems, osteoporosis, and poor oral health

the presence of estrogen receptors detected through immunohistochemistry in the oral cavity plays a significant role in associating the effect of post-menopausal conditions to variations in the oral environment like salivary hypofunction, oral discomfort, and oral mucosal disorders. the vaginal mucosa and oral mucosa are similar histologically due to stratified squamous epithelium and desquamative growth pattern. therefore, the variation in hormonal status in post-menopausal women may lead to the proliferation and maturation of oral epithelium in response to circulating estrogens. the keratinocytes and fibroblasts in the gingival tissues are majorly targeted by estrogen leading to periodontitis, fibroblastic hyperplasia, and desquamatic lesions. therefore, it is a proven fact that gingiva is a traditional estrogen target, leading to the destruction of supporting structures of a tooth, causing periodontitis and thereby exposing tooth structure. another primary oral manifestation in menopausal women is xerostomia/dryness of the mouth. the salivary components provide defense by maintaining the desired ph and decreasing the prevalence of caries, but estrogen levels directly decrease the salivary flow rate. thus, the prevalent acidic ph causes demineralization and destruction of enamel, dentin making it more susceptible to dental caries. a correlation between bone mineral density, salivary calcium levels, and estrogen levels is already established. hence, the salivary calcium levels can indicate increased demineralization of tooth surface and osteoporosis in menopausal. hence, the present focuses on estimating salivary calcium levels and their association with the prevalence of dental caries in post-menopausal women.

Eligibility criteria:
inclusion criteria: * no metabolic disorders * no medications taken in the past 3 months * no periodontal disease exclusion criteria: * periodontal disease present * metabolic disease present * medications taken in the past 3 months

Keywords: pre-menopausal post-menopausal salivary calcium dental caries
durability and safety of cch with two different injection techniques in cellulite with laxity

Conditions: Cellulite; Laxity; Skin; Edematous Fibrosclerotic Panniculopathy

Summary: all participants who completed the en3835-224 study will be invited to participate in this observational study to evaluate long term durability of response and safety.


Eligibility criteria:
inclusion criteria: 1. have participated in and completed study en3835-224 (parent study). 2. be willing and able to cooperate with the requirements of the study. exclusion criteria: 1. has received any collagenase treatments (eg, santyl® ointment) at any time since 2. has had any surgery, invasive procedure (eg, liposuction), injectable treatment (eg, kybella®) or any similar treatment in the area treated during the en3835-224 study since the completion of that study. 3. has any other conditions that, in the investigator's opinion, might indicate the participant to be unsuitable for the study
vales+tú: targeting psychosocial stressors to reduce latino day laborers (ldl) injury disparities

Conditions: Work-related Injury

Summary: the purpose of this study is to determine the efficacy of vales+tú in reducing hazardous exposures at work and to determine the mediating effect of psychosocial stressors on vales+tú primary outcomes


Eligibility criteria:
inclusion criteria: * self-identify as hispanic or latino * be present at the corner for the purpose of looking for work exclusion criteria: * have not been previously hired to work at a corner * symptoms of covid-19 in the previous 48 hours

Keywords: latino day laborers
music therapy to improve quality of life in sickle cell disease (musiqols)

Conditions: Sickle Cell Disease; Chronic Pain

Summary: the purpose of this pilot study is to investigate the effects of a 6-session music therapy protocol on the pain, mood, quality of life, coping skills, and self-efficacy of adult patients with sickle cell disease (scd) as compared to adult patients with scd who receive standard care alone. the investigators will also determine the feasibility (delivery, acceptability, and usefulness) of the music therapy intervention for pain management and quality of life.


Eligibility criteria:
inclusion criteria: * subject is 18 years or older * subject has a scd diagnosis * subject fits chronic pain criteria in scd * subject has a working email address * subject has access to a mobile device with email and internet capabilities * subject is able to speak and understand english * subject has attended at least 50% of his/her scheduled outpatient visits to the adult scd clinic in the last 12 months exclusion criteria: * subject has a significant visual impairment that has not been corrected * subject has a significant hearing impairment that has not been corrected * subject has a significant cognitive impairment that would prevent subject from participating in the study

Keywords: music therapy sickle cell disease quality of life chronic pain
training dual-task walking after stroke

Conditions: Stroke

Summary: community ambulation is a highly complex skill requiring the ability to adapt to increased environmental complexity and perform multiple tasks simultaneously. deficits in dual-tasking may severely compromise the ability to participate fully in community living. unfortunately, current rehabilitation practice for stroke fails to adequately address dual-task limitations; individuals with stroke continue to exhibit clinically significant dual-task costs on gait at discharge. as a result, many stroke survivors are living in the community with residual deficits that may increase disability in the real world and lead to falls with devastating consequences. to address this issue, the proposed study investigates the efficacy of dual-task gait training on attention allocation and locomotor performance in community-dwelling stroke survivors. because walking in the real world often requires time-critical tasks and obstacle avoidance, the investigators will test the impact of dual-task gait training on cognitive-motor interference during walking at preferred speed and at maximal speed (aim 1), and on locomotor control during obstacle negotiation (aim 2). the investigators will also evaluate the effects of the intervention on community reintegration and participation (aim 3).


Eligibility criteria:
inclusion criteria: * within 3 years of stroke onset * living in the community, operationally defined as living in one's own home, or the home of a friend, relative, or caregiver * walking speed 0.6-1.1 m/s determined during 10-meter walk test * walk without the assistance of another person * medically stable and approved for participation by study physician * intact global cognition indicated by score \> 23 on montreal cognitive assessment * living in the community prior to stroke exclusion criteria: * pre-existing neurological disorders (e.g., parkinson's disease, multiple sclerosis, dementia, traumatic brain injury) * previous stroke with residual motor deficit * uncontrolled hypertension * inability to follow 3-step command * primary uncontrolled hearing impairment * severe uncontrolled visual impairment * any speech-language impairment affecting ability to respond verbally to auditory stimuli * timed up and go test \> 15 seconds * lower extremity amputation * any orthopedic problem affecting gait * concurrent participation in another clinical trial

Keywords: gait dual-task obstacle avoidance attention allocation
effects of kinesio taping vs jones technique on myofascial trigger points in cervicalgia.

Conditions: Cervicalgia

Summary: a large number of workers in different sectors suffer from musculoskeletal neck disorders, which are the most common work-related illness in europe. a multitude of combinations of techniques can be used to treat these conditions, including recorded film and the jones technique. this pilot study examines the efficacy of kinesio taping and the jones technique in improving pain, joint range of motion and muscle tension in active subjects with latent myofascial trigger points. a clinical trial was conducted with 38 patients with neck pain. the sample was randomly distributed into three groups: a jones technique group, a kinesio taping group and a combined therapy group in which both techniques were performed. the duration of treatment was 4 weeks, with a follow-up of 2 weeks. cervical spine joint range of motion, pain and functional disability were assessed with the goniometer, the visual analogue scale, the pressure algometer and the cervical disability index.


Eligibility criteria:
inclusion criteria: * diagnosis of latent pgm in the upper trapezius * have been working for more than 6 months in the center or company * work more than 4 hours a day with the computer * be over 18 years of age and under 64 years of age exclusion criteria: * diagnosis of fibromyalgia * having suffered a cervical sprain * diagnosis of radiculopathy, cervical spine surgery * medical contraindications to neuromuscular bandaging or jones technique * diseases such as diabetes and cancer, pregnancy, and any other pathology that produces neck pain other than that specified in the objective of the study

Keywords: cervicalgia cinta de kinesio técnica de jones fisioterapia puntos de activación.
re-engineered discharge for diabetes care transitions

Conditions: Diabetes Mellitus Type 2; Social Determinants of Health (SDOH); Hospital Readmission

Summary: the goal of this project is to test a novel bedside sdoh screening intervention coupled with post-discharge navigation for hospitalized patients with a diabetes diagnosis to reduce unmet social needs, compared to usual care.

the investigators are conducting this research to test a computer-based screening tool and a care coordination protocol to help people with type 2 diabetes who report unmet social determinants of health. social determinants of health (sdoh) are the conditions in the environments where people are born, live, learn, work, play, worship, and age that affect a wide range of health, functioning, and quality-of-life outcomes and risks. - office of disease prevention and health promotion examples of sdoh include factors such as housing, transportation, education, job opportunities, income, and access to healthy food, clean air and water, and health care services. participants who join this research will be asked to complete a screening survey about their health. then, participants will be randomly assigned (like pulling a name out of a hat) to one of two groups: * those in group 1 will be partnered with a patient navigator whose role will be to review the results of the screening survey and help coordinate care before leaving the hospital and for 90 days after. * those in group 2 will receive treatment as usual. a list of community-based resources will be provided. participants in both groups will complete surveys at the beginning of the study and again at 30 and 90 days after leaving the hospital. the investigators will make reminder calls to participants in both groups about data collection and will collect information from the medical record for as long as 90 days after leaving the hospital.

Eligibility criteria:
inclusion criteria: * adult aged 18 years or older * diagnosed with type 2 diabetes * hospitalized at univ of massachusetts-affiliated hospital * endorsed at least 1 unmet social need via screening survey exclusion criteria: * pregnancy * discharge to short or long-term nursing facility or hospital * medical contraindication * cognitive impairment * unable to provide informed consent

Keywords: diabetes social determinants of health hospital readmission
effect of coconut oil application in reducing water loss from skin of premature babies in first week of life (tewl)

Conditions: Trans Epidermal Water Loss (TEWL)

Summary: the skin of newborn infants is immature and ineffective as a barrier. preterm skin exhibits even more vulnerability to the environment due to poor self regulatory heat mechanisms, paucity of fatty tissue and its thinness. most preterm babies lose up to 13% of their weight as water loss from their skin during the first week of life. many strategies have been utilized by neonatologists to decrease this water loss. oil application on the skin can act as a non permeable barrier and can help in reducing water loss from the skin. edible coconut oil, often used for traditional massage of babies by indian communities, is culturally acceptable and hence the investigators decided to undertake this study to objectively assess the reduction in water loss from skin after oil application


Eligibility criteria:
inclusion criteria: all preterm babies born at the study center with birth weight \< 1500gms were eligible for inclusion in the study. exclusion criteria: 1. babies with birth weight less than 750 gms at birth 2. babies with major congenital malformations. 3. babies with severe asphyxia, hydrops and shock. 4. babies with congenital diseases of skin associated with skin breach or denudation of skin precluding oil application 5. babies with preexisting skin infection such as multiple furuncles (2 or more skin areas - each limb, head, chest, abdomen and back are the individual areas that will be taken as one area

Keywords: preterm vlbw coconut oil application trans epidermal water loss weight gain
aliskiren trial in type 2 diabetes using cardiovascular and renal disease endpoints (core and extension phases)

Conditions: Type 2 Diabetes Mellitus; Cardiovascular Disease

Summary: the purpose of this study was to determine whether, in patients with type 2 diabetes and pre-existing disease of the heart and the circulatory system and/or the kidney, aliskiren at a target dose of 300 mg once daily (compared to placebo), on top of conventional treatment, reduces death and disease caused by the heart, the circulatory system and the kidney. amendment 4 rationale (march 2012) : protocol amendment 4 served to address the data monitoring committee recommendation dated 14 dec 2011 to discontinue study treatment in all participating patients. it also addressed the subsequent health authorities request to implement a 12 month safety follow-up period (actual duration was 9 months in average) post study drug discontinuation.


Eligibility criteria:
inclusion criteria: * type 2 diabetes and at least one of the following: * macroalbuminuria and an egfr ≥30 ml/min/1.73 m2 * microalbuminuria and a reduced kidney function (egfr egfr ≥30 and \<60 ml/min/1.73 m2) * a history of cv disease (previous mi, previous stroke, heart failure, coronary artery disease, history of percutaneous coronary intervention, angiography proven stenosis ≥50% in at least one coronary artery and a reduced kidney function (egfr ≥30 and \<60 ml/min/1.73 m2) * concomitant treatment should follow national guidelines and must include either an angiotensin-converting-enzyme-inhibitor (acei) or an angiotensin-receptor-blocker (arb) but not both. exclusion criteria: * type 1 diabetes mellitus * cardiovascular event or procedure ≤ 3 months prior to visit 1 * unstable serum creatinine * hypertension: mean sitting systolic blood pressure (mssbp) ≥ 135 and \< 170 mmhg or mean sitting diastolic blood pressure (msdbp) ≥ 85 and \< 110 mmhg unless treated with at least 3 anti-hypertensive medications * hypertension mssbp ≥ 170 or msdbp ≥ 110 mmhg * baseline serum potassium \> 5.0 mmol/l * patients who are treated with two renin-angiotensin-aldosterone-system-blockers * patients with nyha class iii or iv heart failure * known renal artery stenosis * previous randomization into the avoid trial (cspp100c2201) exclusion specific to the safety follow-up period: - aliskiren or aliskiren containing fixed combination products must not be used other protocol-defined inclusion/exclusion criteria applied

Keywords: type 2 diabetes mellitus renal morbidity and mortality cardiovascular disease micro-albuminuria macro-albuminuria raas renin inhibitor reduced estimated glomerular filtration rate