Kornimate/medical-research-clean huggingface dataset:
perioperative analgesia by femoral perineural catheter for femoral neck fracture - study ktcol

Conditions: Femoral Neck Fracture

Summary: therapeutic essay of phase iv, monocentric, prospective, randomized, in double-blind during 48 hours(then simple-blind),controlled by placebo. abstract: the increasing incidence of the number of femoral neck fractures and the poor prognosis of this traumatological pathology involves an optimization of the diagnostic, therapeutic and analgesic care. a widespread collectively practice for the analgesia in prehospital or preoperative period is the single injection ("single shot") of local anesthetic with the technique of the femoral or iliofascial block. nevertheless the single injection of a dose of local anesthetic associated or not with analgesic adjuvants, due to their pharmacological properties, can't prolong the efficiency of the loco-regional analgesia more than 12 hours. the aim of our study is to evaluate, in the patients admitted in emergencies for suspicion of femoral neck fractures, the perioperative efficiency of an analgesic treatment using a femoral perineural catheter (inserted from the hospital admission) with continuous infusion of ropivacaïne controlled by placebo (physiological serum).


Eligibility criteria:
inclusion criteria: * femoral neck fracture exclusion criteria: * contraindication with analgesia

Keywords: femoral neck fracture analgesia
effectiveness of the neuromuscular control-based exercise training in the treatment of partial-thickness rotator cuff tears

Conditions: Rotator Cuff Tear or Rupture, Not Specified as Traumatic; Pain, Shoulder

Summary: the aim of this study is to determine and compare the effects of neuromuscular control exercises for the shoulder, and standard conservative exercise programs, which are different forms of exercise and have an important role in the treatment of partial thickness rotator cuff tears on treatment. thus, it is aimed to compare these exercise types with different mechanisms on treatment, to determine the place of neuromuscular control exercises in treatment and whether they are more effective than conventional exercises.

rotator cuff (rc) tear shows different symptoms or sometimes can progress asymptomatic. the most common symptoms associated with rotator cuff tears are loss of shoulder range of motion (rom), shoulder pain exacerbated by overhead activities, nocturnal pain, shoulder dysfunction, and functional limitations. conservative treatment is the first and most preferred procedure in the treatment of partial tears. conservative treatment includes patient education, activity modifications, medication, and physiotherapy and rehabilitation programs. in the literature search, it is seen that the studies on the conservative treatment of partial rc tears often include open kinetic chain-weighted standard exercises and strengthening exercise types. it is seen that stabilization and proprioception-based neuromuscular control exercises of the shoulder, which have an important role in restoring neuromuscular control, which is reported to be impaired in shoulder pathologies, are included in some studies and these exercises are generally added to standard treatment. however, it is not known whether neuromuscular control exercises are more effective than other exercises in the standard rehabilitation programs as a result of the combined application of these exercises in this patient group. for this purpose, it is aimed to compare the treatment efficacy of a group consisting of neuromuscular control exercises for the shoulder and a group consisting of conventional exercises and to determine the place of neuromuscular control exercises in treatment.

Eligibility criteria:
inclusion criteria: * forty years of age or older patients that had been diagnosed for a partial rotator cuff tear that was unrelated to trauma by a specialist orthopedist with mri and physical examination and no other shoulder problems on the diagnosed shoulder were included into this study. exclusion criteria: * patients diagnosed with full-thickness or massive rotator cuff tear, patients who had undergone previous surgery, patients diagnosed with frozen shoulder or glenohumeral instability, and athletic patients younger than 40 years of age with symptoms of acute rc tear were not included in this study.

Keywords: rotator cuff tear physiotherapy rehabilitation neuromuscular control rupture
effect of proton pump inhibitors on cf pulmonary exacerbations

Conditions: Cystic Fibrosis

Summary: gastroesophageal reflux disease (gerd) is a common problem in cystic fibrosis (cf). it may lead to worsening lung function and more respiratory infections for a person with cf. this study will look at treating gerd with a medication, esomeprazole. the medication stops stomach acid from being made. the study will see if there are fewer respiratory infections and improved lung function in patients with cf when taking esomeprazole.

this is a randomized, placebo controlled intervention study in patients with cf who have a history of frequent exacerbations. treatment duration is 6 months.

Eligibility criteria:
inclusion criteria: 1. cystic fibrosis 2. age \> 18 years 3. stable maintenance medical regimen during the previous 6 weeks. 4. negative pregnancy test (women of childbearing potential) at both screening and baseline visits. 5. women of childbearing potential must be using medically acceptable contraception. 6. at least two respiratory exacerbations per year requiring oral and/or intravenous antibiotics for each of the two years prior to study entry, but no more than 4 exacerbations requiring intravenous antibiotics during either of those years. exclusion criteria: 1. previous anti-reflux or peptic ulcer surgery, 2. use of proton pump inhibitor (ppi) within the past two weeks 3. pulmonary exacerbation requiring antibiotics within the previous 2 weeks 4. parenteral hyperalimentation 5. cigarette smoking 6. treatment with azoles, iron, anti-coagulants, digitalis 7. use of any investigative drugs within the previous month. 8. use of over the counter acid suppressor agents (not including acid neutralizers)

Keywords: cf
observational cohort study of patients with castration-resistant prostate cancer (crpc)

Conditions: Prostate Cancer; Castration-resistant Prostate Cancer; Metastatic Prostate Cancer

Summary: the purpose of this study is to describe patterns of care in crpc patients, as well as health-related quality of life (hrqol) outcomes associated with crpc and its management. this study will also describe factors influencing treatment decisions including reason(s) for treatment choices and triggers for treatment changes for crpc as well as describe clinical outcomes based on patient characteristics.


Eligibility criteria:
inclusion criteria: patient inclusion: * patient may have m0 or m1 disease * confirmed diagnosis of crpc defined by both testosterone at castrate levels, as evidenced by a serum testosterone level ≤ 1.73 nmol/l (50 ng/dl) and clear progressive disease, as evidenced by a minimum of two rising psa levels measured at least 7 days apart or new clinical or imaging evidence of progressive metastatic disease * initiating the first or second line treatment for crpc: including anti- androgens, androgen synthesis inhibitors, chemotherapy, immunotherapy or radionuclide therapy. previous first line crpc treatments are limited to: first generation anti-androgens (bicalutamide, flutamide, or nilutamide) or sipuleucel-t * patients may be enrolled within 90 days from the time of decision to treat or within 90 days of treatment initiation. * willing and able to complete periodic patient-reported outcome (pro) questionnaires, with or without assistance * estimated life expectancy of ≥ 6 months caregiver inclusion: * meets the definition of an unpaid relative or friend who helps the patient with his or her activities of daily living * willing and able to complete caregiver-reported outcome questionnaires over the course of the patient's participation in the study exclusion criteria: patient exclusion: * receiving concomitant treatment for other cancer (excluding basal cell carcinoma, squamous cell carcinoma and treatment for hormone sensitive prostate cancer) within 6 months prior to enrollment.

Keywords: prostate cancer castration-resistant prostate cancer metastatic prostate cancer
biomarkers and imaging markers for ich

Conditions: Intracerebral Hemorrhage

Summary: intracerebral hemorrhage (ich) is a subtype of stroke associated with high mortality and disability. basic and clinical research has contributed to our understanding of the complex pathophysiology in ich. however, questions regarding acute diagnosis, therapeutic decisions, and prognostication of ich remain unanswered. molecular biomarkers and imaging markers have revolutionalized diagnosis and treatment of many diseases, such as troponin use in myocardial infarction and magnetic resonance imaging (mri) scan in ischemic stroke. therefore, the investigators aim to discovery the potential biomarkers by screening samples of blood, cerebral spinal fluid, urine, saliva, and even tissues (if available) from ich patients, and imaging markers via serial multimodality imaging scans such as computed tomography(ct), magnetic resonance imaging (mri), magnetic resonance spectroscopy (mrs), positron emission tomography (pet), etc. these molecular and imaging markers would assist in contributing additional information to current tools for onset warning, diagnosis, therapy monitoring, risk stratification, intervention and prognosis for ich patients.

intracerebral hemorrhage (ich) is one of the most serious subtypes of stroke, affecting approximately 2-3 million people worldwide each year. about one third of people with ich die early after onset and the majority of survivors are left with major long-term disability. today little is known about the characteristic changes in molecules from body samples and pictures from multimodality imaging scans. in this study, the investigators aim to reveal the potential biomarkers by screening samples of blood, cerebral spinal fluid, urine, saliva, and even tissues (if available) from ich patients, and imaging markers via serial multimodality imaging scans such as computed tomography(ct), magnetic resonance imaging (mri), magnetic resonance spectroscopy (mrs), positron emission tomography (pet), etc, which will bring insights into pathophysiological mechanisms and addition of new tools for onset warning, diagnosis, therapy monitoring, risk stratification, intervention and prognosis for ich patients.

Eligibility criteria:
inclusion criteria: 1. individuals aged 18-80 years 2. hematoma size is more than 5 ml 3. evidence of a spontaneous ich on ct scan 4. patient within 72 hours of ictus 5. glasgow coma scale (gcs) score of 5-15. 6. the history of hypertension exclusion criteria: 1. individuals with age \ 80 years 2. clear evidence that the hemorrhage is due to an aneurysm, arteriovenous malformation or other cerebrovascular diseases. 3. ich secondary to tumor or trauma.. 4. if the haematological effects of any previous anticoagulants are not completely reversed. 5. patients with heart insufficiency, lungs insufficiency, renal insufficiency, hepatic insufficiency, autoimmune diseases and other organ diseases with severe dysfunction.
effectiveness of stability ball training, dead bug exercises, and their combination on reducing specific low back pain

Conditions: Radiculopathy Lumbar

Summary: this study is a single-blinded, randomized controlled trial (rct) focused on individuals aged 30 to 50 with acute specific low back pain (lumbar radiculopathy). participants will be divided into three groups: one performing stability ball exercises, one doing dead bug exercises, and the third group combining both types of exercises.

the study aims to assess the effectiveness of these regimens in reducing pain and improving quality of life. the trial will be conducted at sheikh zayed hospital and alara health care clinic, with simple random sampling used to assign participants. the study will run for 6 months, with follow-up assessments at 1, 4, and 8 weeks.

Eligibility criteria:
inclusion criteria: * participants aged 30 to 50 years with a specific diagnosis of acute lumbar radiculopathy lasting less than three months but severe enough to impair daily activities were included in the study. * they were required to provide informed consent and agree to adhere to the study procedures, * including attending sessions and completing evaluations. eligibility was limited to those without other physical conditions, such as joint replacements or fractures, * that could interfere with the ability to perform stability ball or dead bug exercises. individuals who had participated in similar therapeutic exercises, such as stability ball training or core strengthening, within the last six months were excluded to ensure the results reflected the intervention's impact rather than prior training effects. exclusion criteria: * included participants with severe musculoskeletal or cardiovascular disorders, such as spinal surgery, herniated discs, scoliosis, fractures, or osteoarthritis, due to the potential risks associated with exercise. * pregnant women were excluded as balance-related activities, like stability ball exercises, could pose safety concerns. individuals using pain medications, particularly opioids or muscle relaxants, were excluded to avoid interference with exercise performance or altered pain perception. * participants who had undergone back surgery within the last six months, or those currently undergoing other physical therapy or treatments for back pain, such as physiotherapy or chiropractic care, in the previous month were also excluded
connected electronic wrist strap for patient follow-up after cardiac surgery

Conditions: Cardiac Surgery; Surgery--Complications; Cardiac Disease; Physical Disability

Summary: after cardiac surgery, patients' follow-up after discharge is a major public health issue. since the main complications occur mostly during the first extra-hospital month, a follow-up period becomes necessary as the average duration of hospitalization tends to decrease. the resumption of normal physical activity is rarely transmitted and when complications arise, the healthcare team is most often informed late. an electronic wristband is worn by the patient during the day, between the day of discharge from the hospital (d0) and the end of the second extra-hospital month (d60). the data recorded by the wristband include : bracelet id, date, time and number of steps per day. the primary objective of the study is to measure the resumption of physical activity after elective cardiac surgery. this objective will be quantified by the number of daily footsteps. a secondary objective is to determine perioperative predictors of the physical resumption.


Eligibility criteria:
inclusion criteria: * adult patients who underwent elective cardiac surgery, regardless of indication and type of intervention. exclusion criteria: * refuse of the patient, * misunderstanding of the system (electronic wristband, application) or the principle of the study (language problem, cerebral vascular sequelae), * pre-existing handicap that does not allow walking (not related to the cardiac pathology leading to the planned cardiac surgery). * patients who are unable to understand the content of the information delivered * pregnant women can not be included in the study.
gdnf gene therapy for multiple system atrophy

Conditions: Multiple System Atrophy

Summary: the objective of this randomized, double-blinded, placebo-controlled phase 1 investigation is to evaluate the safety and potential clinical effect of aav2-gdnf delivered to the putamen in subjects with either a possible or probable diagnosis of multiple system atrophy.


Eligibility criteria:
inclusion criteria: * male and female 35-75 years of age (inclusive) * clinical diagnosis of msa, parkinsonian type with symptoms onset sporadic, progressive and \> 30 years of age * less than 5 years from msa parkinsonian diagnosis with expected survival more than 3 years * stable anti-parkinsonian medication regimen * ability to walk a distance of 25 feet with or without an assistive device exclusion criteria: * presence of idiopathic parkinson's disease (pd) or any pd-related mutation or other neurological diseases * presence of dementia, psychosis, substance abuse or poorly controlled depression * prior brain surgery (i.e., deep brain stimulator implantation) or other brain imaging abnormalities * history of cancer or poorly controlled medical conditions that would increase surgical risk * received investigational agent within 12 weeks * inability to tolerate laying flat in an mri and/or allergy to gadolinium note: other protocol defined inclusion/exclusion criteria may apply.

Keywords: msa multiple system atrophy neurotrophic factor growth factor glial cell line-derived neurotrophic factor gdnf aav gene therapy
use of a video decision tool to improve informed decision-making in hospitalized patients considering palliative radiation therapy

Conditions: Metastatic Cancer or Locally Advanced; Patients Receiving Palliative Radiation

Summary: the purpose of this study is to assess the effectiveness and acceptability of a recently created informative video geared for patients who have been evaluated by a radiation oncologist for palliative radiation therapy during a hospitalization at memorial sloan-kettering cancer center. palliative radiation therapy is radiation therapy that is given to patients with the purpose of easing symptoms from cancer. it is not given with the intent to cure the cancer. the video presents basic information about palliative radiation and palliative care.


Eligibility criteria:
inclusion criteria: * age ≥18 years * eligible for palliative radiation to the brain, spine, chest, abdomen, pelvis, skin, or bone as per the judgment of the radiation oncologist or nurse practitioner * patient is english-speaking and able to give informed consent and fill out study questionnaires * hospitalized at mskcc * pathologically confirmed malignancy * cancer is metastatic or locally advanced, and is not curable * patients who may undergo radiation at a satellite facility are still eligible for protocol enrollment exclusion criteria: * those who have seen the video beforehand

Keywords: palliative radiation 12-172
pembrolizumab in combination with epacadostat or placebo in cisplatin-ineligible urothelial carcinoma (keynote-672/echo-307)

Conditions: UC (Urothelial Cancer)

Summary: the purpose of this study was to evaluate the efficacy and safety of pembrolizumab + epacadostat vs pembrolizumab + placebo in participants with cisplatin-ineligible urothelial carcinoma.


Eligibility criteria:
inclusion criteria: * histologically or cytologically-confirmed diagnosis of advanced/unresectable (inoperable) or metastatic urothelial cancer of the renal pelvis, ureter, bladder, or urethra. * measurable disease based on recist v1.1. * be considered ineligible to receive cisplatin-based combination therapy, based on protocol-defined criteria. * have provided tissue for pd-l1 analysis from an archival tissue sample or newly obtained core or excisional biopsy of a tumor lesion not previously irradiated. * have received no prior systemic chemotherapy for advanced/unresectable (inoperable) or metastatic urothelial cancer. * eastern cooperative oncology group (ecog) performance status of 0, 1, or 2 within 14 days prior to randomization. * adequate organ function per protocol-defined criteria. exclusion criteria: * disease that is suitable for local therapy administered with curative intent. * known additional malignancy that is progressing or has required active treatment within the past 3 years. * known active central nervous system (cns) metastases and/or carcinomatous meningitis. participants with previously treated brain metastases may participate provided they are radiologically stable, ie, without evidence of progression for at least 4 weeks by repeat imaging, clinically stable and without requirement of steroid treatment for at least 14 days prior to first dose of study treatment. * active autoimmune disease that has required systemic treatment in past 2 years. * known history of human immunodeficiency virus (hiv) infection. hiv testing is not required unless mandated by local health authority. * known history of or is positive for active hepatitis b (hepatitis b surface antigen \[hbsag\] reactive) or has active hepatitis c (hcv rna). note: testing must be performed to determine eligibility. * history of a gastrointestinal condition that in the opinion of the investigator may affect oral drug absorption. * history or presence of an abnormal electrocardiogram (ecg) that, in the investigator's opinion, is clinically meaningful. * use of protocol-defined prior/concomitant therapy.

Keywords: urothelial cancer, programmed cell death 1 (pd-1) inhibitor indoleamine 2,3-dioxygenase (ido) inhibitor
sex, hormones and gamma-aminobutyric acid (gaba) in stress induced anhedonia in depression

Conditions: Major Depressive Disorder

Summary: using an innovative multi-modal imaging approach, this study investigates the role of the neurochemical gamma-aminobutyric acid (gaba), brain activity, as well as hormones in understanding sex differences in major depressive disorder (mdd). further, the investigators will link these markers to symptoms of depression.

the goals of this research are to investigate: (1) functional and neurochemical features associated with depression irrespective of clinical state; (2) moderating effects of hormones on stress circuitry in mdd; and (3) sex differences in symptoms. to this end, the study is enrolling adults with current depression and remitted depression, along with a control group of psychiatrically health adults. participants will have an magnetic resonance imaging (mri) exam involving multiple imaging techniques (functional, structural, spectroscopic) while performing computer-based tests. additional questionnaires and tests will be done outside the scanner to assess current symptoms and hormone levels. the integration of laboratory-based measures of reward and stress sensitivity, with state-of-the-art imaging techniques and hormonal assessments promises to provide novel insights in the sex-dependent manifestation and pathophysiology of mdd.

Eligibility criteria:
inclusion criteria for all participants. * males and females aged 18 through 25 * capable of providing written informed consent, and fluent in english * right-handed * absence of any psychotropic medications for at least 2 weeks * female subjects will be scheduled to participate during the follicular phase of their menstrual cycle inclusion criteria for "current mdd" group: * meets inclusion criteria for all subjects, plus: * meets diagnostic criteria for a current episode of major depressive disorder (mdd), as defined by the diagnostic and statistical manual of mental disorders (dsm-5). inclusion criteria for "remitted mdd" group: * meets inclusion criteria for all subjects, plus: * history of mdd as defined by dsm-5, but in remission for the past two months * absence of anxiety disorder for the past two months exclusion criteria for all participants: * history of psychiatric illnesses, other than depression or anxiety disorders among the current mdd and remitted mdd groups. * history of psychotic episodes, suicidal ideation, or of electroconvulsive therapy (ect) treatment * use of hormone replacement therapy, or of anabolic steroids. * use of hormonal contraceptives is permitted for female subjects only if the subject has regular menses * failure to meet any mri safety requirements * serious or unstable medical illness, or history of neurological disease or damage * history of use of cocaine, stimulants, or dopaminergic drugs * history of substance use disorder or alcohol use disorder (as these terms are defined by dsm-5); except depressed subjects may have a history of 'mild' substance/alcohol use disorder only if it ended as least 12 months ago.

Keywords: gaba depression stress androgens