Kornimate/medical-research-clean huggingface dataset:
effects of dry needling in patients with upper cross syndrome

Conditions: Neck Syndrome

Summary: the study will be done to evaluate the effectiveness of dry needling of muscles involved in upper cross syndrome. muscles involved in upper cross syndrome are tight upper trap, levator scapulae, sternocledomastoid , pectorals major and minor and rhomboids. physical assessment of trigger points will locate the target area for dry needling. after pre treatment measurements, dry needling will be performed to treatment group and stretching, hot pack and tens will be apply in control group. study design will be randomized controlled trial and sample size will be 34 participants. data will be collected from riphah rehabilitation center. patients of 20-50 years old with ucs diagnosed through observation and physical examination will be included. patients with systemic soft tissue and bony diseases will be excluded. intervention duration will be two session of dnt with two weeks routine management. basic tools will be visual analog scale (vas), neck disability index (ndi) and goniometry

dry needling is relatively new method for the management of musculoskeletal pain.different methods of dry needling, its effectiveness, and physiologic and adverse effects are discussed. dry needling is a treatment modality that is minimally invasive, cheap, easy to learn with appropriate training, and carries a low risk. the deep method of dry needling has been shown to be more effective than the superficial one for the treatment of pain associated with myofascial trigger points. however, over areas with potential risk of significant adverse events, such as lungs and large blood vessels, we suggest using the superficial technique, which has also been shown to be effective. questionnaire for assessing the improvement in quality of life is by ndi and ranges like neck flexion/extension, side bending and rotation will be measured by standard goniometry. neck disability index will use to check the patient's ability to perform his adl before and after the treatment/control. data will be collected from riphah rehab center. assessed patients of ucs of age 20 to 50 will be the targeted population of this study. patients with systematic and bony disease excluded from the study. population having stiff upper back, tight trap and stiff upper thoracic spine have ucs. ethical guidelines will be followed for both treatment and control group. spss version 21 will be use for data analysis with sample size of 34 participants, 17 participants each group that will randomly allocated in treatment/control group.

Eligibility criteria:
inclusion criteria: * stiffness and gradual pain in neck and shoulder * pain due to postural dysfunction * trauma or insidious onset exclusion criteria: * any systemic soft tissue and bony disease. * patient with spinal tuberculosis, spinal fractures, pregnancy, cancer. * any recent surgery. * patient with any cervical or thoracic problem. * patients with any other serious pathology/red flags

Keywords: dry needling, upper cross syndrome, vas, ndi, goniometry
acute pain rate of single versus two-visit root canal treatment of teeth with necrotic pulps

Conditions: Pain, Postoperative

Summary: aim to compare acute pain rate after single-visit ortwo-visits treatment of teeth with necrotic pulp and apical periodontitis .90 teeth with a diagnosis of pulp necrosis and apical radiolucency at the apex.working length was established with eal and confirmed radiographically. flex-r files were used to complete canal preparation. level ofdiscomfort were recorded and cases with acute postoperative pain.

90 teeth with a diagnosis of pulp necrosis and apical radiolucency at the apex.working length was established with eal and confirmed radiographically. m4system with flex-r files were used to complete canal preparation. level ofdiscomfort were recorded and cases with severe postoperative pain and/orswelling were classified as acute pain.

Eligibility criteria:
inclusion criteria: a) radiographic evidence of apical periodontitis (minimum size ≥2.0mm x 2.0 mm) and a diagnosis of pulpal necrosis confirmed by negativeresponse to hot and cold tests and b) need for retreatment. thermal pulptesting was performed by the author, and radiographic interpretation wasverified by one certified oral surgeon - exclusion criteria: * patients without inclusion requirements or failure to obtain patient ́sauthorization. patients, were excluded if they were younger than 18 yearsold, pregnant, had a positive history of antibiotic use within the past month,suffered from diabetes, or other systemic diseases. teeth with periodontalpockets deeper than 4 mm also were excluded of the study
use of probiotics to aid in weight loss

Conditions: Weight Loss

Summary: the purpose of this study is to evaluate the success of daily supplementation of multiple probiotic bacterial cultures over 12 weeks in increasing the percentage of excess weight loss in the rnygb (gastric bypass) weight loss population.

hypothesis: the daily supplementation of a probiotic will increase weight loss compared to a placebo supplement in the post-operative gastric bypass patients. study design: all patients in this study will be scheduled to undergo the rnygb (gastric bypass) procedure to assist in weight loss. patients in this study will be randomized to one of two groups: group 1 (probiotics) or group 2 (placebo). patients will begin supplementation at the beginning of their 4 week pre-surgery optifast© 800 diet. all patients will take supplements for a total of 12 weeks. nutritional education and support will be provided to each patient enrolled in the study. weight loss will be measured using a machine that measures body composition. all patients will complete a quality of life questionnaire with regard to gastrointestinal health and a hair loss survey pre treatment and at the end of the study.

Eligibility criteria:
inclusion criteria: * male or female at least 18 years of age * signed informed consent * willingness to take a supplement once a day for 12 weeks * undergoing a rnygb (gastric bypass) procedure * willingness to complete quality of life questionnaire and hair loss survey exclusion criteria: * pregnant female * lactating female * male or female less than 18 years of age * patients on chronic antibiotic treatment (prescribed more than 2 courses of antibiotics over the 12 week study period) * patients who have demonstrated medical therapy non-compliance past or present

Keywords: weight loss probiotics gastric bypass
dry needling & trigger point compression release in neck pain

Conditions: Neck Pain; Trigger Point Pain, Myofascial; Neck Muscle Issue; Muscle Tightness; Neckache

Summary: this randomized control trial was conducted to investigate the efficacy of trigger point dry needling which is a modern treatment intervention compared with ischemic compression release in the patients having neck pain due to myofascial trigger points.

many treatment protocols have been used in the clinical arena for the improvement of neck pain but un-availability of follow-up studies and lack of evidence of modern treatment interventions are few shortcomings a researcher faces. thus, a need stands up to address these perspectives for newer treatment strategies. this randomized control trial is conducted to investigate the efficacy of trigger point dry needling which is a modern treatment intervention compared with ischemic compression release in the patients having neck pain due to myofascial trigger points. findings of this research will assist in creating awareness about better treatment intervention for trigger point release among medical community.

Eligibility criteria:
inclusion criteria: * patients between the age group of 20 to 40 years. * both male and female patients. * patients presenting with neck pain due to mtrp's. * the presence of a palpable taut band in the neck region. * patients reporting typically referred pain pattern of the mtrp in response to compression. exclusion criteria: * patients with any associated comorbidities such as hypertension and diabetes. * patients with known history of fibromyalgia syndrome, whiplash injury, cervical spine surgery fracture and cervical radiculopathy. * patients with any systemic disease such as rheumatism and tuberculosis or cervical myelopathy and multiple sclerosis. * patients with history of myofascial trigger point therapy one month prior to enrollment. * patients with non-cooperative attitude, fear or any contraindications to needling.

Keywords: dry needling ischemic compression neck pain
written exposure therapy versus prolonged exposure: a non-inferiority trial

Conditions: PTSD

Summary: the goal of this study is to examine whether a brief, exposure-based treatment (written exposure therapy) approach is just as effective in the treatment of posttraumatic stress disorder (ptsd) compared with a more commonly used time-intensive approach called prolonged exposure. one hundred and fifty veterans diagnosed with ptsd will be randomly assigned to either written exposure therapy or prolonged exposure. veteran participants will be assessed at pre-treatment, and 10-, 20-, and 30- weeks post first treatment session. primary outcome measure will be ptsd symptom severity. the secondary outcome measure will be quality of life. in addition, treatment dropout during the first five sessions will be examined. wet is expected to have a lower treatment dropout rate relative to pe.

although written exposure therapy (wet) is listed in the upcoming va/dod ptsd practice guidelines as an evidence-based, recommended ptsd treatment, there are limited data supporting the use of wet with veterans suffering from ptsd. additional research is needed to support the use of wet for the treatment of veterans diagnosed with ptsd. the goal of this study is to investigate whether wet is non-inferior in the treatment of ptsd in a sample of veterans diagnosed with ptsd. men and women veterans diagnosed with ptsd will be randomly assigned to either wet (n = 88) or prolonged exposure (pe; n = 90). ptsd symptom severity will serve as the primary outcome. quality of life will serve as a secondary outcome measure. assessments will be conducted by independent evaluators at baseline, 10-, 20-, and 20-week post first treatment session. wet is expected to be non-inferior to pe in reducing ptsd symptom severity and functioning. in addition, wet is expected to have significantly lower treatment dropout rate relative to the first five sessions of pe (i.e., better treatment engagement). if wet is found to be non-inferior to the more time intensive pe treatment then the va will have evidence to support the use of a brief ptsd treatment, which will assist in addressing the high demand for ptsd clinical services.

Eligibility criteria:
inclusion criteria: * veteran status * current dsm-5 diagnosis of ptsd (assessed with the clinician administered ptsd scale for dsm-5; caps-5) * if taking psychotropic medication, on a stable dose for at least 30 days prior to study entry exclusion criteria: * current engagement psychosocial treatment for ptsd * current diagnosis of substance dependence * abuse will not be excluded; determined with severe combined immunodeficiency (scid) * current psychosis or unstable bipolar disorder diagnosis * determined with the mini international neuropsychiatric interview (mini)clinician-administered interview * high suicidal risk * i.e., intent with a plan; assessed with the mini suicide module * significant cognitive impairment (assessed with the montreal cognitive assessment \[moca\] and clinical judgment)

Keywords: ptsd psychosocial treatment cognitive behavioral treatment veterans quality of life
pain mechanisms in patients with bronchiectasis

Conditions: Bronchiectasis; Respiratory Disease

Summary: pain mechanisms and their clinical impact in patients with bronchiectasis have not been investigated yet. the aim of the research is to assess the presence of central pain mechanisms in patients with bronchiectasis using the quantitative sensory testing (qst) assumptions.

background and objective: recent findings suggest that pain can play an important role in terms of physical activity limitation in respiratory patients. nevertheless, pain mechanisms and their clinical impact in patients with bronchiectasis have not been investigated yet. the objective of the observational study is to determine the somatosensorial profile in order to assess the presence of central pain mechanisms in patients with bronchiectasis. methodology: repeated-measures prospective cross-sectional study. a sample of patients diagnosed with bronchiectasis will be recruited and matched by age and sex with healthy controls. pressure pain thresholds (ppts), conditioned pain modulation (cpm) and referral pain will be assessed before and after the incremental shuttle walking test (isw). levels of physical activity will be assessed using accelerometry during a 7-days period. sleep quality (pittsburgh sleep quality test), level of catastrophizing (pain catastrophizing scale), level of sensitization (central sensitization inventory) and level of anxiety and depression (hospital anxiety and depression) will be assessed. the assessments will be done twice: 1) at baseline; and 2) at 6 months follow-up period.

Eligibility criteria:
bronchiectasis group inclusion criteria: * diagnosis of bronchiectasis by high-resolution computed tomography. * ability to understand and perform all the clinical procedure. * acquisition of informed consent. exclusion criteria: * diagnosis or clinical suspicion of cystic fibrosis by genetic test or sweat electrolytes test. * diagnosis of rheumatic disease. * being on a waiting list for lung transplantation. * thoraco-abdominal surgery in the last 6 months. * chronic use of pain medication. control group inclusion criteria: * healthy subjects matched by age and sex with bronchiectasis group's subjects exclusion criteria: * be taking pain medication. * presence of pain condition or pathology.

Keywords: bronchiectasis pain mechanisms pressure pain threshold referred pain
dietary allowance of methyl donor nutrients to minimize risks of non-alcoholic fatty liver progression

Conditions: Non-alcoholic Fatty Liver Disease

Summary: investigate the methyl donors requirement of nafld patients to correct the malnutrition, lipid-toxicity, microbiota dysfunction, and metabolomics biomarkers.

folate/choline/betaine, service as a methyl-donor nutrients, are essential nutrients involving in hepatic one-carbon and bioenergetic metabolism. methyl-donor nutrients deficiency cause liver and muscle dysfunction as result of non-alcoholic fatty liver diseases (nafld) and its progressive lesions of steatohepatitis (nash), fibrinogen cirrhosis and hepatoma. as methyl-donor nutrients intakes in taiwanese population are highly insufficient, the dietary requirement of methyl-donor nutrients upon genetic, epigenetic and microbiota interaction to prevent or/and co-therapy of nafld progression is currently not known. in this study, we investigate whether intervention of methyl-donor nutrients improve or retard nafld progress. nafld patients are randomly divided into three groups and received placebo, folic acid, or choline, respectively. from first day to ten day, interventions are given double recommended daily intake dose of folic acid or double adequate intakes dose of choline, then continuing with four times, and eight times dose for every 10 days. all supplements solve in cranberry juice. at the end of every ten days intervention prior, interventions are measurement of weight and body fat, and collection of blood and feces. the primary outcome measures are described to decreased body weight or body fat, improvement of liver function and fatty liver, and increasing methyl-donor nutrients levels.

Eligibility criteria:
inclusion criteria: * nafld/nash patients * folate levels in plasma \< 6 ng/ml or choline levels in plasma \< 5 micromol per liter * folate intake \< estimated average requirement or choline intake \< 50% adequate intakes * homocysteine levels in plasma \> 9 micromol per liter exclusion criteria: * asymptomatic carrier of hepatitis b and c * liver disease except nafld * taking drugs that causes fatty liver * inflammation about stomach or intestines * pregnancy * cancer except liver cancer * heart disease, vascular disease, or psychosis * intake alcohol over 100 g or unaccessible intake alcohol

Keywords: methyl nutrients non-alcoholic fatty liver gut-liver axis metabolomics
impact of genetic counseling for individuals with mental illness

Conditions: Schizophrenia; Bipolar Disorder; Schizoaffective Disorder

Summary: people who have experienced mental illnesses like schizophrenia, bipolar disorder or schizoaffective disorder often have a poor understanding of the causes of their illness, and that they are often very worried about how the illness affects their families. in particular, affected individuals worry that there is a high chance that any children that they have will become affected with the same illness. often, because of this fear, affected individuals choose not to have children. genetic counseling is a process where information about the causes of illnesses, and about chances for family members of individuals with these illnesses to become similarly affected is provided in a supportive environment by a specially trained healthcare professional. this study will investigate whether genetic counseling can reduce perceptions of risk and stigma, and increase perceived control and knowledge about the causes of the illness, amongst individuals who have a major mental illness.

we will recruit 120 individuals who have a personal history of a major psychiatric disorder (as defined above). each participant will be randomized into one of 3 groups of approximately equal size: one of which will receive genetic counseling within 1 month after enrollment (gc), another will receive the educational brochure within 1 month (eb), and the last will be assigned to waitlist (wt). after randomization (but prior to intervention for gc and eb groups, and within 1 month after enrollment for the wt group) we will gather baseline information regarding the 4 outcome measures (perceived risk and control, stigma, and knowledge). we will re-assess the 4 outcome measures immediately post-intervention for gc and eb groups. a further follow-up (for all groups) will be conducted two months after enrollment (which is 1 month post intervention for gc and eb groups).

Eligibility criteria:
inclusion criteria: * fluent in english * have been diagnosed with schizophrenia, bipolar, or schizoaffective disorder * reside in bc, and be able to attend 3 study visits over 1.5 months

Keywords: schizophrenia bipolar disorder schizoaffective disorder genetic counseling risk perception stigma control knowledge
non-invasive determination of cardiac output by inertgas rebreathing method

Conditions: Cardiac Diseases

Summary: the cardiac output (co) is an important parameter in the diagnosis and therapy of cardiac diseases. the current standard methods for the determination of the co, however, are either invasive (e.g. right heart catheterization) or technically expendable and expensive (magnetic resonance tomography, mrt). the traditional non-invasive methods of determining the co by rebreathing of carbon dioxide are easily carried out but suffer from methodical inaccuracies. therefore the aim of the study at hand was to evaluate a new method for determining the co by means of the inert gas rebreathing method.


Eligibility criteria:
inclusion criteria: * indication for cmr * ability of following instructions for rebreathing test

Keywords: indication for cmr
economic evaluation and communication in remote monitoring of people with pacemakers

Conditions: Cardiovascular Disease

Summary: the purpose of this research is to estimate the outcomes in health and cost of the follow-up of patients with pacemakers. the initial hypothesize of this study is that remote monitoring of pacemaker will show a best relation of outcomes in costs and effectiveness than the conventional follow-up in hospital.

cardiovascular diseases are a major cause of global morbidity and mortality, being responsible according to the world health organization of the 30% of overall mortality. since 2001 that the first pacemaker of remote monitoring was implanted in europe, more than 300,000 pacemaker have been implanted around the world. despite this sharp expansion, the scientific evidence on economic evaluations of pacemaker with remote monitoring is very limited, and in our knowledge, studies including informal costs have not been conducted. in the field of cardiology, telemedicine allows consultations with patients through monitoring systems and remote communication analyzing the ongoing heart rates of people with pacemakers, implantable cardioverter defibrillators, cardiac resynchronization therapy and subcutaneous holter. the use of remote monitoring may save time and efforts to both healthcare professionals and patients, including their informal caregivers, reducing the number of follow up visits to the hospital and reducing the associated costs with patient follow-up, which will help to improve sustainability of healthcare services. during the 06 months of study, the patients with implant of pacemakers of both groups will be assessed of the same parameters, in 3 different moments (pre-implant and months 1, and 6 post-implantation). pacemakers that are going to be used in the project: 1. remote monitoring group: biotronik estella sr-t and dr-t \& biotronik evia sr-t and dr-t. 2. hospital monitoring group: st jude medical endurity sr and dr \& sorin reply 200 sr and dr. the study will estimate: 1) the clinical features of the patients. 2) the effectiveness through of administration of health-related quality of life questionnaires and 3) finally, hospital and informal costs of patients with pacemakers will be estimated by the researches.

Eligibility criteria:
inclusion criteria: * be 18 years of age * have a pacemaker implanted * understand and be able to properly perform self-monitoring at home exclusion criteria: * be participating in another study * refuse to participate in the study * have implanted a different cardiac device to the pacemaker

Keywords: follow-up studies biological pacemakers telemedicine efficiency