Kornimate/medical-research-clean huggingface dataset:
the immunologic reaction to polypropylene mesh in inguinal hernioplasty

Conditions: Inguinal Hernia

Summary: the notable development and diffusion of prosthetic surgery of the abdominal wall over the last few years has led to the introduction of light weight meshes. the efficacy of inguinal hernia repair with light weight prosthesis, as well as the better or worse biotolerability with respect to those of light weight, remains questionable in literature, where a clear answer still remains to be given. if there exists a connection between the quantity of material implanted, the immunological reaction to the mesh, the induced oxidative stress and the degree of cicatrization, and consequently the long-term result of the efficacy of the operation, remains to be demonstrated. there are few studies on the immunological reaction to polypropylene meshes, and none on the oxidative stress induced by the mesh. moreover, only one study has been published that clearly correlates the immunological reaction to the amount of prosthetic material, but was carried out on only a few patients. the aim of this research is to show if there is a relationship between the amount of prosthetic material used and immunological reactions as well as postoperative oxidative stress, and thus to evaluate, if present, the differences in the biological reaction and biotolerability between light-weight and heavy-weight meshes on a statistically significant number of patients.

double blind randomization. the recruitment of patients will take place in the order that they are referred to the hernia service of the general surgery and week surgery unit of the university hospital of catania. after the examination confirming the diagnosis of inguinal hernia and once surgery has be indicated, informed consent will be obtained from the patient by means of a standardized form. the assignment to group h or group l will be made following a simple criterion of alternation that is completely random: i.e. patient 1 (group h), patient 2 (group l).a total of 60 patients will be recruited and divided into the two groups. for group h inguinal hernioplastic surgery will be carried out with the so called "heavy-weight" mesh (about 220 g/m2 of polypropylene), for group l, on the other hand, the mesh will be of the "light-weight" type (about 40 g/m2). a preoperative blood test will be carried out to determine the basal levels of il-6, tnf-alpha, nitrites, gsh and isoprostanes) and 3 postoperative tests (at 6 h, 3 days and 12 days), all samples will be frozen for reference. all the data from each patient will be collected in a personal file compiled by the surgeon. when all the blood samples are collected a laboratory technician and a biochemist will determine the levels of the above mentioned substances, these data will then undergo statistical evaluation.

Eligibility criteria:
inclusion criteria: * all patients affected by primary inguinal hernia exclusion criteria: * diabetes * corticosteroids treatment * immunosuppressive drugs * cirrhotic patients * chronic inflammatory disease * neoplastic patients

Keywords: inguinal hernia immune system cytokines prosthetic repair oxidative stress
evaluation of periapical healing following endodontic microsurgery with leukocyte and platelet rich fibrin (l-prf)

Conditions: Apical Periodontitis

Summary: the purpose of the study is to evaluate peri-radicular healing after root-end surgery using leukocyte and platelet rich fibrin. the study population includes patients diagnosed with persistent periapical pathology and scheduled for endodontic microsurgery at the university of pennsylvania school of dental medicine, department of endodontics. patients undergoing routine endodontic microsurgery and who meet the inclusion criteria will be given the opportunity to opt in to receive l-prf in the osteotomy site to promote bone formation. healing will be assessed radiographically and clinically at six, twelve, eighteen, and twenty-four months.


Eligibility criteria:
inclusion criteria: 1. provision of signed and dated informed consent form. 2. stated willingness to comply with all study procedures and availability for the duration of the study, including the follow-up visits. 3. male or female age \>18 years old. 4. in good general health (asa 2 or less) with no contraindications for endodontic microsurgery. 5. persistent endodontic periapical pathology class a, b, or c according to the kim and kratchman classification (5) 6. intact coronal restorations with no evidence of leakage or caries under the restoration. exclusion criteria: 1. minors. 2. suspected root fractures. 3. asa classification 3 or greater. 4. periapical pathology class d, e, or f according to the kim and kratchman classification (5). 5. patients with history of oral or iv bisphosphonate use. 6. patients may be excluded if their treatment team do not believe endodontic microsurgery and l-prf graft is in the patient's best interests.
improving the pregnancy rate with endometrial sampling before intrauterine insemination

Conditions: Infertility; Clinical Pregnancy Rate

Summary: endometrial sampling improves the pregnancy rates in superovulation-iui cycles

endometrial sampling is performed using the standard technique in the outpatient department. similarly, superovulation with gonadotrophins will be performed according to our standard practice.endometrial sampling will be done in the follicular phase not later than day 10 of the cycle. endometrial sampling will be performed using pipelle sampling catheter. the pipelle is inserted gently through the cervical canal into the uterine cavity and advanced slowly till just resistance felt by the operator. then, the piston is withdrawn to create negative suction and gentle movement of pipelle up and down in the uterine cavity is performed while it is against the uterine wall. the pipelle catheter is withdrawn gently and any obtained specimen will be sent for histopathological examination.

Eligibility criteria:
inclusion criteria: 1. all women undergoing superovulation with gonadotrophins and intrauterine insemination. 2. all women with cervical factor, mild male factor and/or unexplained infertility. 3. at least one patent fallopian tube. exclusion criteria: 1. bilateral tubal disease 2. severe male factor infertility 3. intrauterine pathology (submucosal fibroid, endometrial polyp, adhesions) 4. women with positive cervical culture and/or acute vaginal infection

Keywords: infertility clinical pregnancy rate
clinical effects of lumbal stabilization exercises and connective tissue massage on neuropathic pain, functional capacity and quality of life

Conditions: Peripheral Neuropathy

Summary: the aim of the study is to investigate the efficacy of connective tissue massage and lumbar stabilization exercise treatment on pain severity, functional capacity and quality of life in those who have experienced peripheral neuropathy

the patients diagnosed with fine fiber neuropathy by the neurology department of hacettepe university will be included and the patients referred to physical therapy will be included. patients meeting the inclusion criteria will be randomly divided into 3 groups by simple randomization. the first group consisted of lumbal stabilization exercises, the second group with connective tissue massage and the third group with only medical treatment. all patients will be evaluated 2 times before and after 6 weeks. the treatment will be 2 days per week for 6 weeks. exercise programs of the patients will be performed under the supervision of physiotherapist. in the first group, lumbal stabilization exercises will be applied for 6 weeks and the second group will be given connective tissue massage. statistical analysis of the study will be done using spss 21 statistical program. in the statistical analysis to be carried out within the scope of the study, p value will be selected as 0.05 and p \<0.05 will be considered significant. mean ± standard deviation, number, percentage, minimum and maximum values will be used as descriptive statistics. wilcoxon test is used to compare the pre- and post-treatment values of the groups in the variables and the kruskal-wallis test will be used to compare the groups with each other.

Eligibility criteria:
inclusion criteria: * diagnosed small fiber neuropathy * score-4 and over from the -dn4 score * 18-65 years old adults * volunteers to participate in the study. exclusion criteria: * pain from different etiologies * other neurological disorders involved in neuropathy evaluation * cognitive or reading disorders to prevent the questionnaires from being filled * people with musculoskeletal or orthopedic disorders that affect exercise will not be included.
a magnetic resonance imaging study of patients with cervical spondylosis

Conditions: Cervical Spondylosis

Summary: this study aims at evaluating spinal cord structure using diffusion tensor imaging in patients with cervical spondylosis.

diffusion tensor imaging (dti) of the cervical spinal cord will be performed in patients with cervical spondylosis with varying degrees of symptoms and in healthy control subjects. fibre tracking of main spinal tracts will be performed. regions of interest will also be identified. diffusion parameters will be extracted. this will allow quantification of degree of damage in of the spinal cord. the findings will be related to motor function measures and comprehensive clinical tests of sensory and motor function.

Eligibility criteria:
inclusion criteria: * 18-70 years old * sufficiently cooperative * cognitively understands study and implications * signed informed consent * symptomatic cervical spondylosis exclusion criteria: * mri contraindications (e.g., pacemaker, metal implants, claustrophobia) * previous pathology that would impact behavioural measures * anxiety and poor cooperation * previous neurological condition * pregnancy

Keywords: spinal cord cervical spondylosis myelopathy
multi-disease carrier screening test validation

Conditions: Spinal Muscular Atrophy (SMA); Carrier Screening; Genetic Testing

Summary: the purpose of this study is to collect blood samples to enable validation of genetic testing for diseases within a multi-disease carrier screening panel. samples will be collected from adult women or men who have previously tested positive as carriers for various recessive conditions. these are healthy adults who carry a mutation that might place them at increased risk of having a child with a specific genetic disorder. study participation will be open to adults that were previously tested as part of their routine medical care and where test results demonstrated positive carrier status for a specific genetic disease. samples will be tested for the disease mutation for which the subjects provides documentation of prior testing.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * individuals who are carriers of an smn1 deletion consistent with spinal muscular atrophy carrier status and are able to provide documentation of carrier status determined from prior testing * able to provide a blood sample * pregnant women may be include in the study exclusion criteria: * minors under the age of 18 years * individuals who are not carriers of a spinal muscular atrophy mutation * individuals who are unable to provide documentation of spinal muscular atrophy carrier status.

Keywords: spinal muscular atrophy (sma) carrier screening genetic testing
the colic study: colonization of the infant gut with b. infantis evc001 to reduce symptoms of colic

Conditions: Infantile Colic

Summary: to investigate whether b. infantis evc001 colonization in the infant gut can reduce symptoms of colic

there is evidence to support that b. infantis evc001 supplementation may ameliorate symptoms associated with colic by establishing and maintaining the necessary gut microbial composition to promote proper barrier and immune function in infants. the primary objective of this study is to assess the effect of the probiotic, b. infantis evc001, on reducing the duration of crying/fussing symptoms of breastfed infants diagnosed with infantile colic from baseline to day 14.

Eligibility criteria:
inclusion criteria: * infants with a diagnosis of infantile colic per rome iv criteria and reported to cry/fuss for ≥ 3 hours/day, within a 24-hour period as determined by the 24-hour cry/fuss ediary and 24 hours of lena vocalizations * infants with a gestational period of ≥ 37 to 42 weeks * infants between 14 and ≤ 42 days of life at the completion of screening/baseline tasks * infants exclusively breastfed for at least 7 days immediately prior to enrollment and with mother's intent to continue feeding breast milk exclusively for the duration of the study * mothers willing to use their own electronic device(s) to download and utilize all required study software (decentralized trial platform on a mobile device and the lena device software on a windows 10 or higher laptop or desktop that has at least 10 gb of free space and fast, reliable internet) * mother is fluent in english exclusion criteria: * infants born in multiple birth (i.e., twins, triplets, etc.) * infants born with medical complications (i.e., neurological, cerebral palsy, confirmed food allergies) * infants with current evidence of failure to thrive, fever, or illness * infants with any gi tract abnormalities * antibiotic, infant formula, solid food or iron supplement intake within 7 days prior to enrollment or mother's intent to feed non-study probiotics, prebiotics, infant formula, solid food or iron supplements to their infant at any time during the study * infants who have consumed any probiotics since birth * unwillingness to discontinue/avoid products used to treat ic (i.e., simethicone, gripe water, colic drops, etc.) during the study. note: consumption of ic products prior to the baseline period is not exclusionary * maternal use of probiotics containing b. infantis during pregnancy, after the baby's birth and/or intent to use probiotics containing b. infantis at any time throughout the study * maternal smoking or smoking within the home by any household member currently or during pregnancy * mother following exclusionary diet due to her infant's colic (i.e., dairy elimination diet) * any infant the investigator deems to be ineligible for participation
poc-hcv genedrive viral detection assay validation study

Conditions: Hepatitis C

Summary: the principal objective is to assess the diagnostic accuracy of the poc assay (genedrive, epistem) to detect hcv rna against the reference standard of commercial real-time polymerase chain reaction (rt-pcr) assay (realtime hcv, abbott) using stored heparinized plasma from patients with chronic hepatitis c and non-infected controls.


Eligibility criteria:
inclusion criteria: criteria for case * age \> 18 years old. * patients with positive hcv rna. * heparinized plasma samples are available before the initiation of antiviral hcv therapy. * patients have given a written consent that their blood samples will be further used for research. criteria for control * age \> 18 years old. * participants were tested negative for anti-hcv antibody * heparinized plasma samples are available * participants have given a written consent that their blood samples will be further used for research exclusion criteria: -

Keywords: hcv genedrive point of care
validity of cow's milk-related symptom score among children suspected to have cow's milk protein alergy

Conditions: Cow's Milk Allergy

Summary: cow's milk protein allergy is a sensitivity reaction against cow's milk protein and and is calcified as ige-medaited, non- ige mediated and mixed type according to the underlying immunological mechanism. cow's milk related symptom score ( comiss) considers general manifestation and dermatological, gastrointestinal and respiratory symptoms.


Eligibility criteria:
inclusion criteria : * age: from birth up to five years... * sex: both males and females * all children who suspected to have cow's milk allergy that have the following symptoms (chronic unexplained failure to thrive, regurgitation , chronic abdominal distension, skin manifestation such as urticaria \& eczema and respiratory symptoms such as chronic cough, recurrent wheezy chest). exclusion criteria * functional git disorders such irritable bowel syndrome , gastroesophageal reflux disease according to rome iv criteria in children * organic gastrointestinal diseases like coeliac disease , cystic fibrosis. * chronic gastrointestinal infections as parasitic infections.
study to assess the long term safety and tolerability of act-541468 (daridorexant) in adult and elderly subjects suffering from difficulties to sleep

Conditions: Insomnia Disorder

Summary: study to assess the long term safety and tolerability of daridorexant in adult and elderly subjects suffering from difficulties to sleep


Eligibility criteria:
inclusion criteria: * signed informed consent prior to any study-mandated procedure (visit 1). * having completed the db study treatment and the run-out period of id-078a301 (nct03545191) or id-078a302 (nct03575104). * for woman of childbearing potential, the following is required: * negative urine pregnancy test (eot of id-078a301 or id-078a302 studies) * agreement to use the contraception scheme as required by the protocol from visit 1 up to at least 30 days after eodbt. exclusion criteria: * unstable medical condition, significant medical disorder or acute illness, c-ssrs©, ecg, hematology or biochemistry test results in id-078a301 and id-078a302, which in the opinion of the investigator could affect the subject's safety or interfere with the study assessments (visit 1). * for female subjects: lactating or planning to become pregnant during the duration of the study (visit 1). * positive urine drug test (for benzodiazepines, barbiturates, cannabinoids, opiates, amphetamines, or cocaine) or presence of alcohol in exhaled breath as detected by breathalyzer test (eot of id-078a301 or id-078a302 studies if same day as visit 1 or visit 1 if within 7 days after eot).
a proof of principle study of aminolevulinic acid (ala) - induced fluorescence detection in resectable non-small cell lung cancer

Conditions: Lung Cancer in Normal and Malignant Tumors

Summary: the purpose of this trial is to measure ala-induced fluorescence in both normal and malignant tissue.


Eligibility criteria:
inclusion criteria: * inclusion criteria patients (12 total patients with lung cancer) meeting eligibility criteria will be enrolled. * preoperative diagnosis of either presumed or documented non-small cell lung cancer. * tumor judged to be suitable for surgical resection based on preoperative evaluation of radiographic studies, pulmonary function tests, performance status and clinical judgment of surgeons at dhmc (erkmen, nugent) * age ≥ 18 years old. * population representative of our usual referral pattern including minority populations, women and those who are financially disadvantaged. * subjects capable of giving informed consent exclusion criteria: * pregnant women * women who are breast feeding * history of cutaneous photosensitivity * porphyria, hypersensitivity to porphyrins, photodermatosis * exfoliative dermatitis * history of liver disease within the last 12 months * inability to comply with photosensitivity precautions associated with the study * inability to give informed consent * ast, alt, alp or bilirubin levels greater than 2.5 times the normal limit at any time during the past 2 months * plasma creatinine in excess of 180 umol/l * women who are breast feeding * history of cutaneous photosensitivity * porphyria, hypersensitivity to porphyrins, photodermatosis * exfoliative dermatitis * history of liver disease within the last 12 months * inability to comply with photosensitivity precautions associated with the study

Keywords: ala florescence lung cancer
clinical validation of radiomics artificial intelligence: application to breast cancer treatment planning

Conditions: Breast Cancer

Summary: radioval will develop and implement interoperable solutions for clinical deployment of the radiomics tools, including information, training, and communication packages for clinicians and patients, as well as standard operating procedures for the integration of radiomics in clinical oncology. with this study, we will clinically validate these solutions, by looking at their reliability for precise breast cancer diagnosis, treatment recommendation and prognosis estimate, treatment response, evaluation of residual disease and outcome prediction.


Eligibility criteria:
inclusion criteria: * females ≥ 18 years up to 85 years old * individuals referred to hospitals for diagnosis of breast cancer * availability of radiological images: 2d mammography or 2d synthetic digital tomosynthesis, ultrasound, or magnetic resonance * availability of pathological report (surgical specimen) * availability of (neoadjuvant) treatment allocation (scheme, duration, benefit) * availability of treatment response exclusion criteria: * patient with incomplete or low-quality data (radiological, pathological or clinical)
kinesiotaping versus functional electrical stimulation on equinus deformity

Conditions: EQUINUS DEFORMITY

Summary: effect of fes versus no fes intervention. a statistically significant between-group difference in activity in favor of fes was reported for all 3 studies, immediately after the intervention period. this difference represented a 30% to 32% greater increase in activity compared with no fes intervention. a follow-up measurement was reported for 1 study, but no data were reported. effect of fes versus activity training. both studies reported a statistically nonsignificant between-group difference in activity compared with activity training, immediately after the intervention period. one study included a follow-up measurement, but no data were reported

this study will be conducted at the outpatient clinics, faculty of physical therapy kafrelsheikh university to prove the effect of core stability exercises on standing , balance and gait in diplegic cp children. the children will be randomly allocated by simple random method via choosing one of two wrapped cards representing the two treatment groups, which are: group (a): will receive core stability exercises in addition to the designed physiotherapy program. group (b): will receive the designed physiotherapy program only . inclusion criteria children will be included in the study if they fulfil the following criteria: 1. a medical diagnosis of diplegic cp made by paediatricians or pediatric neurologists. 2. children with spasticity grades ranged from 1 to 1+ according to mas. 3. their age range from 4 to 10 years. 1. children were level i or ii on the gross motor function classifcation system (gmfcs) 5.no orthopedic surgeries. exclusion criteria children will be excluded from the study if: 1. they had a permanent deformity (bony or soft tissue contractures). 2. children having visual or auditory defects. 3. children who had botox application to the lower extremity in the past 6 months or had undergone a previous surgical intervention to ankle and knee. 4. a history of epileptic seizure and any diagnosed cardiac or orthopaedic disability that may prevent the use of assessment methods. 5. children who are absent in two successive sessions.

Eligibility criteria:
inclusion criteria: * 1. a medical diagnosis of diplegic cp made by paediatricians or pediatric neurologists. 2. children with spasticity grades ranged from 1 to 1+ according to mas. 3. their age range from 4 to 10 years. 1. children were level i or ii on the gross motor function classifcation system (gmfcs) 5.no orthopedic surgeries exclusion criteria: 1. they had a permanent deformity (bony or soft tissue contractures). 2. children having visual or auditory defects. 3. children who had botox application to the lower extremity in the past 6 months or had undergone a previous surgical intervention to ankle and knee. 4. a history of epileptic seizure and any diagnosed cardiac or orthopaedic disability that may prevent the use of assessment methods. 5. children who are absent in two successive sessions.

Keywords: kinesotaping functional electrical stimulation equinus deformity diaplegic cerebral palsy