Kornimate/medical-research-clean huggingface dataset:
diagnosis of subclinical urinary tract infections using advanced microbiome survey techniques in high risk trauma patients

Conditions: Urinary Tract Infection

Summary: the purpose of this study is to see if the investigators can identify early those patients who are admitted to the hospital and have a urinary tract infection (uti) or those patients that develop a uti during their hospitalization.


Eligibility criteria:
inclusion criteria: * 65 years old or older admitted as a result of trauma to saint marys hospital at mayo clinic exclusion criteria: * prisoners * pregnancy * active urinary tract stones * less than 65 years of age
comparison of different physiotherapy methods in people with non-specific neck pain

Conditions: Neck Pain

Summary: the study will include 45 people between the ages of 25-55 with non-specific neck pain. the patients will be randomly divided into three groups. group 1 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (tens), and hot pack application. group 2 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (tens), and hot pack application in addition to the mulligan mobilization technique. group 3 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (tens), and hot pack application in addition to graston treatment for 5 minutes to the upper and lower trapezius, rhomboid major and minor muscles.

the study will include 45 people between the ages of 25-55 with non-specific neck pain. the patients will be randomly divided into three groups. group 1 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (tens), and hot pack application. group 2 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (tens), and hot pack application in addition to the mulligan mobilization technique. group 3 will receive 5 minutes of ultrasound, 20 minutes of transcutaneous electrical nerve stimulation (tens), and hot pack application in addition to graston treatment for 5 minutes to the upper and lower trapezius, rhomboid major and minor muscles. the patients will receive treatments 3-4 times a week for 4 weeks, for a total of 10 sessions. vas, neck joint range of motion, functional status and disability level neck pain and disability scale and sf-36 will be used as evaluation measurements.

Eligibility criteria:
inclusion criteria: * patients diagnosed with non-specific neck pain by a doctor * aged between 25-55 * who have had pain in their neck for at least 2 weeks will be included in the study. exclusion criteria: * neurological disease * manual therapy contraindication such as osteoporosis, spinal infection * spondyloarthropathy, disc herniation * people with contraindications to the graston technique such as neoplastic disorders, anticoagulant drug use, uncontrolled hypertension or general infection will not be included in the study

Keywords: non specific neck pain physiotherapy applicaitons pain
associations of exposure to bisphenol a with blood pressure and epigenetic change

Conditions: Hypertension

Summary: * bisphenol a(bpa) is an endocrine disrupting chemical, which mimics the action of estrogen. * previous studies reported that bpa exposure is associated with increased risk of cardiovascular diseases. * exposure to bpa occur mainly through oral route, and epoxy coating of canned food is one of the well established source. * the investigators hypothesis is that increased bpa exposure from canned beverage would disrupt normal physiology in a short term. * in the present trial the investigators are to investigate whether increased bpa exposure by consuming canned beverage actually affect cardiovascular indices and epigenetic feature. * for this aim, the investigators will conduct a cross-over trial.


Eligibility criteria:
inclusion criteria: * reside in seoul * who provided informed consent exclusion criteria: * who has cancer * who has disease or disorder of liver, nervous system, endocrine system, cardiovascular system * who does not provieded informed consent
color ii: laparoscopic versus open rectal cancer removal

Conditions: Rectal Cancer

Summary: color ii is a randomized, international, multi center study comparing the outcomes of laparoscopic and conventional resection of rectal carcinoma below 15 cm with curative intent. clinical and operative data will be collected centrally in the coordinating centre in halifax, canada. quality of life and costs will be assessed on a national basis.

the design involves allocation of all suitable consecutive patients with rectal carcinoma to either of the two procedures at a randomization ratio of 2:1 in favor of the laparoscopic procedure. excluded are patients with a carcinoma treated by local resection and palliative resections. the trial will be stratified according to participating centre, resection type, and preoperative radiotherapy. if the 95% ci for the difference of the 3-year locoregional recurrence rates excludes a difference greater than 5% in favor of the conventional procedure, non-inferiority of the laparoscopic procedure will be concluded. assuming both rates are 10%, 1000 evaluable cases are required in total for a power of 80%. analysis will be primarily on an intention to treat basis. definition of conversion is defined by protocol.

Eligibility criteria:
inclusion criteria: * solitary rectal cancer observed at colonoscopy or on barium x-ray * no evidence of distant metastases * distal border of the tumor within 15 cm of the anal verge at rigid rectoscopy or under linea conjugata at lateral barium enema radiography * suitable for elective surgical resection * informed consent exclusion criteria: * t1 tumors treated by locl excision * t4 tumors * patients under 18 years of age * signs of acute intestinal obstruction * more than one colorectal tumor * familial adenomatosis polyposis, hereditary non-polyposis colorectal cancer * active crohn's or active ulcerative colitis * scheduled need for other synchronous colon surgery * preoperative indication of invasion of adjacent organs, immobile at palpation or ct showing invasion * preoperative evidence of metastases (at least chest x-ray and liver ultrasound) * other malignancies in medical history except adequately treated basocellular carcinoma of the skin or in situ carcinoma of the cervix uteri * absolute contraindications to general anesthesia or prolonged pneumoperitoneum (asa class \> iii) * pregnancy

Keywords: rectal cancer laparoscopic technique open technique clinical trial multicenter study randomized controlled trial tumor below 15cm curative surgical resection no evidence for distant metastases
treatment of covid-19 by nebulization of inteferon beta 1b efficiency and safety study

Conditions: COVID-19; INTERFERON; NEBULIZATION

Summary: covid-19 is causing a serious viral pandemic in terms of health and social impact. to date, no treatment has yet demonstrated strong efficacy in treating the infectious disease (covid-19). pulmonary administration of interferon (ifn) type i is a therapeutic strategy with high potential,due to higher local concentrations and minimal adverse effects. type i interferons (including ifn-α and ifn-β) are antiviral defence cytokines and also have the potential to negatively modulate ifn type ii and il-6 dependent cytokine storm, the latter being induced in the late forms of covid-19. in vitro, ifn-β were more effective on covid-19 than ifn-α. in existing preliminary studies, only patients receiving ifn type i modulators have a decrease in viral carriage and a rapid reversal. the purpose of this project is to assess in hospitalized patients with oxygen for covid 19, the clinical efficacy on oxygen requirements of the addition of inhaled interferon type i compared to the control arm .


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * patient with laboratory-confirmed sars-cov-2 infection as determined by pcr \< 96 h (at initial diagnosis or persistent carriage \<96 h) * hospitalized patient with covid-19 requiring oxygen therapy and targeting in phase b : * patients under oxygen therapy such as nasal cannula/mask or non-invasive ventilation with pao2/fio2 \> 200 mmhg. * patients hospitalized for less than 7 days. * patients with symptoms for less than 10 days or rt-pcr (\<96h) with cycle treshold \< 25. * social security coverage * signed informed consent (by patient or their legally authorized representative) exclusion criteria: * hypersensitivity to natural or recombinant interferon-ß * hypersensitivity to human albumin or mannitol * recent suicide attempt * decompensation of liver failure * age \< 18 years * pregnant or nursing. * patients managed on an outpatient basis (i.e. not initially hospitalized). * parenteral ifn treatment. in periode b, addition of new exclusion criteria * patients with kidney transplant * immunocompromised patients * patients with severe systemic disease constantly threatening their vital prognosis (asa ≥ iv: e.g. severe arf, advanced cancer pathology, recent myocardial idm, severe valvular dysfunction, dependence on parenteral nutrition on central line, shock, sepsis, trauma, ...). * patients in septic shock. * patients with documented fungal infection. * patients on mechanical ventilation. * patients hospitalized for covid-19 for more than 7 days.

Keywords: covid-19 interferon nebulization
italian registry of cardiovascular magnetic resonance on congenital anomalies of the coronary arteries (itaca-registry)

Conditions: Congenital Coronary Artery Abnormality

Summary: italian registry of coronary artery abnormalities diagnosed utilizing cardiac magnetic resonance imaging.

congenital coronary anomalies (acc) are relatively rare heart disease, in which a congenital defect of origin, course, and term, of one or more epicardial cardiac coronary arteries, is recognized. the global prevalence is estimated at around 0.6-0.7% in the general population, where the most frequent accs consist of the anomalous origin of the right coronary artery from the left breast (arca), with a prevalence of 0.23%; while the anomalous origin from the sn coronary artery from the right breast (alca) would seem to have a prevalence of 0.03%. accs have often been associated with an increased risk of sudden cardiac death (scd), especially in athletes. in fact, within this population, accs are counted as the second most frequent cause of scd after hypertrophic cardiomyopathy. in the general population, the risk of sudden death from alca is estimated at around 6.3% at 20 years, while for arca it is estimated at around 0.2% at 20 years. the estimated incidence in athletes instead recognizes a range that varies between 0.5 and 13 deaths per 100,000. although acc are therefore recognized as a frequent cause of sudden cardiac death, a recent english study, conducted on a population of 11,168 young footballers, showed a significantly lower incidence than expected: only two coronary anomalies, an alca and an arca, respectively; the prevalence was therefore 0.002%, at least 10 times lower than expected. the most common manifestations of acc are chest pain, palpitations, dizziness and syncope, although more than 50% of patients with acc are asymptomatic. in the past, these anomalies could only be described at autopsy, while thanks to the enormous developments that the different cardiac imaging modalities have undergone in recent years, accs can now also be detected non-invasively. the initial diagnosis is echocardiography, but a confirmation method is necessary (ct, mri, or coronary angiography), moreover most of the time the finding can be completely incidental and found in the course of examinations conducted for another reason. this registry will enroll patients from different sites in italy (who decided to join the registry within the italian society of cardiology) objectives aiming at establishing the clinical and imaging correlates in patients with congenital anomalies of coronary origin, found or confirmed by cardiac magnetic resonance imaging. as secondary endpoint will be observed subpopulations of patients: 1) in competitive athletes; 2) patients with ventricular ectopic beats (lown class ≥2).

Eligibility criteria:
inclusion criteria: * patients with anomalous origin of the coronaries diagnosed with cardiac magnetic resonance imaging exclusion criteria: * patients with known ischemic heart disease * patients with coronary atherosclerotic disease
research of automated maculopathy screening based on ai techniques using oct images

Conditions: Maculopathy

Summary: the investigators expect to develop an algorithm that can interpret oct images and automated determine whether the macula is normal or not by using oct image-based deep learning techniques. and investigators wish to develop software applications that will help better screen and diagnose macular diseases in resource-limited areas.

the investigators will apply deep learning convolutional neural network by using imagenet for an automated detection of multiple retinal diseases with oct horizontal b-scans with a high-quality labeled database. datasets, including training dataset, testing dataset and validation datasets, will be built by ophthalmologists of the first affiliated hospital of nanjing medical university according to the standardized annotation guidelines.

Eligibility criteria:
inclusion criteria: * all patients attending the ophthalmology department of the first affiliated hospital of nanjing medical university within 5 years and who received known, clear diagnoses with digital retinal imaging (including oct, fundus digital photographs and fundus fluorescein angiography, at least with oct images) as part of their routine clinical care, will be eligible for inclusion in this study. exclusion criteria: * hardcopy examinations (i.e., photos of paper reports of oct imaging performed at other hospitals) will be ineligible. * data from patients who have previously manually requested that their data should not be shared, even for research purposes in anonymised form, and have informed the ophthalmology department of the first affiliated hospital of nanjing medical university of this desire (even in previously conducted studies or other on-going studies in this hospital), will be excluded, and their data will not be upload to the cloud platform before research begins. * data from eyes tamponed with silicone oil or gas (i.e., c3f8) will be ineligible. * data with poor image quality, such as incomplete images, inverted images, blurred or cracked images and images with a very weak signal (i.e., vitreous haemorrhage), will be ineligible.

Keywords: macular diseases screening oct deep learning ai
ambient light levels in the kindergarten and schools and the relation to refractive development

Conditions: Myopia

Summary: myopia, the most common human eye disorder, is a phenomenon characterized by an unconstrained elongation of the eye globe there are number of theories concerning the environmental effect on the emmetropization process, most are related to childhood exposure to outdoor activity, near work and sleep with night light. studies in lab animals found an association between intensity of ambient lighting and myopia development. in this study, the investigators will examine the ambient light in kindergarten and schools and their relation to refractive error. diurnal luminance in kindergarten and school class room will be measured and correlated to biometric measures such as refraction, axial length and keratometry.


Eligibility criteria:
inclusion criteria * every child that have been studying in the same class for the last 6-12 months (kindergarten and school respectively). exclusion criteria * noncooperative child or parents. * ocular surgery. * ocular genetic disease.

Keywords: effects heat light
cardiovascular diagnosis using µ-cor - an interventional pilot trial

Conditions: Congestive Heart Failure

Summary: subjects that are being treated at the congestive heart failure clinic in nazareth will be given the µ-cor system to be added to their standard care, and randomized 1:1 to an interventional arm or a control arm.


Eligibility criteria:
inclusion criteria: * men or women 20-90 years old. * new york heart association (nyha) class iii-iv heart failure * followed by the congestive heart failure (chf) clinic in nazareth * left ventricular ejection fraction \<35% * requiring treatment with \>40mg/day of furosemide\* orally or with repeated bolus or intravenous infusion of furosemide\* (\*or equivalent bumetanide or torasemide). exclusion criteria: * pregnancy * subjects who have received a heart transplant. * subjects who are unable or unwilling to follow the study requirements. * patients with allergies or skin sensitivities to electrode hydrogel and/or acrylic based adhesive. * patients with skin breakdown in areas on the chest where device and electrode placement is required
intraoperative radiotherapy for korean patients with breast cancer

Conditions: Breast Cancer

Summary: the purpose of this study is to evaluate acute local toxicity of iort at the dose of 20 gy for the replacement of boost-external beam radiotherapy in korean women who are candidates for breast-conserving treatment.

local toxicity checklist * hematoma needing surgical evacuation * seroma needing more than three aspirations * skin breakdown or delayed wound healing * any complication needing surgical intervention * radiation therapy oncology group (rtog version 2.0) toxicity grade 3 or 4 for dermatitis, telangiectasia, pain in irradiated field, or other. * any complication of rtog toxicity grade more than 2

Eligibility criteria:
inclusion criteria: * histologically confirmed and newly diagnosed non-metastatic operable primary breast cancer * primary tumor \<5cm, measured by ultrasonography - n0-3 (any n if resectable) and no evidence of distant metastasis (m) (isolated supraclavicular node involvement allowed) * age ≥18-years women with good performance status (ecog 0-1) * no breast operation is allowed except diagnostic biopsy * women with ductal carcinoma in situ diagnosed by preoperative biopsy are allowed exclusion criteria: * pregnancy or unwillingness to use a reliable contraceptive method in women of child-bearing potential. * patients who received prior chemotherapy or radiotherapy for breast cancer * patients who have history of cancer other than in situ uterine cervix cancer or non-melanoma skin cancer * the depth of tumor from skin measured by ultrasonography is less than 1cm. * contraindications to breast conservative surgery * multicentric breast cancer (tumors in more than one quadrant) * diffuse malignant appearing microcalcification * prior therapeutic radiation to the breast region * small breast, which is not possible to achieve clear margins in relation to a cosmetically acceptable result * history of collagen vascular disease, such as active scleroderma and active lupus * postoperative exclusion * patients who require re-excision due to positive resection margin * the depth of cavity from skin after lumpectomy is less than 0.5cm

Keywords: breast cancer breast conservative surgery intraoperative radiotherapy local toxicity whole breast radiotherapy
a study comparing leo 80190 ointment with hydrocortisone ointment, both applied once daily in the treatment of psoriasis vulgaris on the face and intertriginous areas

Conditions: Psoriasis Vulgaris

Summary: an international, multi-centre, prospective, randomised, double-blind, active-controlled, 2-arm, parallel group, 8-week, phase 3 clinical study in paediatric patients (aged 6 to 17 years) with psoriasis vulgaris on the face and on the intertriginous areas


Eligibility criteria:
inclusion criteria: * clinical diagnosis of psoriasis vulgaris involving the face * clinical signs of psoriasis vulgaris on the trunk and/or on the limbs, or earlier diagnosed with psoriasis vulgaris on the trunk and/or limbs. the extent and severity of psoriasis vulgaris on trunk and/or limbs should be amenable to topical therapy with any of the allowed medications * an extent of psoriatic involvement of the face of at least 5 cm2 (the sum of all facial lesions) * treatment areas (the face and the intertriginous areas) amenable to topical treatment with a maximum of 30 g (6 to 11 years) or 45 g (12 to 17 years) of ointment per week * disease severity graded as mild, moderate or severe according to the investigator's global assessment of disease severity of the face * aged 6 to 17 years exclusion criteria: * systemic treatment with therapies other than biologicals with a potential effect on psoriasis vulgaris within the 4-week period prior to randomisation * systemic treatment with biological therapies (marketed or not marketed) with a possible effect on psoriasis vulgaris within 4 weeks (etanercept), 2 months (adalimumab, alefacept, infliximab), 4 months (ustekinumab) or 4 weeks/5 half-lives (which-ever is longer) for experimental biological products prior to randomisation * puva therapy or grenz ray therapy within the 4-week period prior to randomisation * uvb therapy within the 2-week period prior to randomisation * topical treatment of psoriasis vulgaris lesions on the face or on the intertriginous areas within the 2-week period prior to randomisation * topical treatment with very potent who group iv corticosteroids within the 2-week period prior to randomisation * initiation of or expected changes to concomitant medication that may affect psoriasis vulgaris (e.g., beta blockers, anti-malaria drugs, lithium and ace inhibitors) during the treatment phase of the study * current diagnosis of erythrodermic, exfoliative or pustular psoriasis
fitness level in short stature children and after growth hormone treatment

Conditions: Fitness

Summary: fitness and physical activity will be evaluate in short stature children, using the euro fitness testing and the wingate anaerobic test. the fitness level will be evaluate in healthy short children and with growth hormone deficiency at base line and after 6 month .

the euro fitness testing which is a series of field testing for children evaluating aerobic, strength and flexibility and the wingate anaerobic test which is a 30 seconds maximum pedaling against resistance on bike for evaluating the anaerobic fitness. the fitness test will be done in healthy short stature children and in growth hormone deficiency or idiopathic short stature from the endocrine unit in meir medical center the test will be done at base line and after 6 month . the fitness test in child with growth hormone deficiency will be done before starting gh treatment and 6 month later. the child will be asked to fill a questioner about his daily physical activity anthropometric measurement will be taking including weight, height and fat percent. details about age, sex, tanner stage, indication for growth hormone, dose, insulin growth factor-1 (igf1) level will be taken from the medical file.

Eligibility criteria:
inclusion criteria: * short stature * physical healthy * mental healthy * capable to perform fitness test exclusion criteria: * cardiac disease that interfere or risk the child during physical activity * respiratory disease that interfere or risk the child during physical activity * musculoskeletal disease interfering physical preformance. * family history of death for unknown reasons at an early age. * uncontroled thyroid diseae

Keywords: short stature fitness children