Kornimate/medical-research-clean huggingface dataset:
pinto beans and glycemic control in adults with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: this study examines the impact of daily consumption of ½ c pinto beans, compared to a control (½ c green beans), on fasting glucose, postprandial glucose and hba1c concentrations in adults with type 2 diabetes mellitus (t2dm).

this study utilized a randomized, pretest-posttest, crossover (within-group) design, that includes two treatment periods \[control period (½ c. green beans each day) and pinto beans (½ c each day)\], each 12-weeks in duration with a 4- week wash-out period to determine the impact on fasting glucose, postprandial glucose and hba1c concentrations. after a baseline wash-in period, 16 participants are randomly assigned to 2 treatment periods \[control period and pinto beans\], each 12-weeks in duration. on 28 randomized days during the wash-in period and interventions, participants keep diet records and measure a postprandial capillary glucose concentration using a glucometer 1 hour after the meal during which the pinto beans or control are consumed. before and after each 12-week intervention, participants provide a fasted venous blood sample for glucose and hba1c analyses.

Eligibility criteria:
inclusion criteria: * diagnosis of t2dm by a physician; * currently attempting control of t2dm by diet or metformin; * fasting glucose ≥ 90 mg/dl (confirmed by fasting blood draw or potential participant provided lab analysis conducted within last 30 days) and/or hemoglobin a1c ≥ 6.5% (confirmed by blood draw or potential participant provided lab analysis conducted within last 30 days); * body mass index (bmi) of 22-40 kg/m2; * no unresolved health conditions and no diagnosis of gastrointestinal disease; * limited history of legume intake; * willingness to follow study protocol, scheduling, and ability to come to the testing location; * no recent weight gain or loss (\>10% over 6 months); * no use of medications and/or dietary supplements other than metformin that affected glucose; * women could not be pregnant or breastfeeding; * habitual alcohol consumption had to be less than 2 drinks per day (specifically ≤ 720 ml of beer, 240 ml of wine, or 90 ml of hard liquor). exclusion criteria: * non compliance with above inclusion criteria.

Keywords: pulses legumes phaseolus vulgaris l. glycemic response
cross cultural validation of the italian version of the clinical assessment of dysphagia in neurodegeneration

Conditions: Swallowing Disorder; Dysphagia; Neuro-Degenerative Disease

Summary: the english version of the "clinical assessment of dysphagia in neurodegeneration" (cadn), represents a rapid and valid clinical assessment tool for dysphagia in neurodegenerative population. currently, there is no validated tool in italian specific for the clinical assessment of dysphagia in neurodegenerative disease with strong psychometric characteristics. the present study aims to translate and validate the italian version of cadn in neurodegenerative population. psychometric properties will be measured.

most of patients with a neurodegenerative disease will develop swallowing impairments (dysphagia) during their disease progression (up to 80%- 100% in parkinson disease and amyotrophic lateral sclerosis). dysphagia is associated with serious clinical complications, particularly regarding loss of life quality, insufficient medication intake, malnutrition, dehydration, and aspiration with subsequent pneumonia, which is the leading cause of death in this population. early detection and measurement of dysphagia trough validated and standardized procedures plays a fundamental role in the clinical practice. clinical assessment by a speech language pathologist (slp) can provide early identification of dysphagia and its severity and direct clinical decision making. the english version of the "clinical assessment of dysphagia in neurodegeneration" (cadn), represents a rapid and valid clinical assessment tool for dysphagia in neurodegenerative population. currently, there is no validated tool in italian specific for the clinical assessment of dysphagia in neurodegenerative disease with strong psychometric characteristics. the present study aims to translate and validate the italian version of cadn in neurodegenerative population. the study will be carried out in two phases: 1. forward and back translation 2. validation process

Eligibility criteria:
inclusion criteria: * diagnosis of neurodegenerative disease according to the respective consensus criteria * \>18 years old * able to provide informed consent * able to follow simple instructions * capable of sitting upright for anamnesis and examination for at least 20 min (in chair or wheelchair) exclusion criteria: * history of stroke * surgery to the head or neck * radiotherapy in the last 12 months * dysphagia resulting from other known causes
evaluation of the efficacy and the safety of a stereotaxic prostatic radiotherapy delivered with linac mri, in patients with prostate adenocarcinoma

Conditions: Adenocarcinoma of the Prostate

Summary: stereotaxic prostatic radiotherapy on linac mri, with monitoring of movements of the pelvic organs per fraction on the prostate in real time, in 4 sessions, with integrated boost on the index tumor (if it is visible on the diagnostic mri), could reduce the digestive, urinary and sexual toxicities accumulated at 5 years and guarantee excellent local tumor control, for patients with localized prostate cancer, with a favorable prognosis, intermediate or very local high risk, according to the d'amico classification. the benefits that patients participating in this research could obtain are: * better disease control efficiency * a reduction in the duration of treatment to 4 radiotherapy sessions (2 weeks maximum) instead of 40 sessions (8 weeks) for usual treatment. * avoid the risks associated with the implantation of prostate markers necessary for stereotaxic radiotherapy on a standard accelerator (anesthetic risks, infectious risks, hemorrhagic risks, pain risks) * better quality of life


Eligibility criteria:
inclusion criteria: 1. prostate adenocarcinoma 2. who performance index ≤ 1 3. patient presenting one of the following cases: * low risk: ≤ t2a and gleason 6 (3 + 3) and psa \<10 ng / ml * intermediate risk: t2b-t2c or gleason 7 or psa \<15 ng / ml * high localized risk: t3a and gleason ≤7 and psa \<15 ng / ml 4. disease presenting a risk of lymph node involvement \<15% 5. absence of pelvic or lumbar aortic lymphadenopathy 6. absence of bone or visceral metastasis 7. ipss score \<15 or ≤ 7 8. prostate volume estimated by mri or ultrasound \< 90cc 9. if hormonotherapy, hormone therapy must not have started for more than 60 days before inclusion. 10. absence of prior pelvic radiotherapy 11. no surgical treatment for prostate cancer exclusion criteria: 1. prostate cancer of histology other than adenocarcinoma 2. contraindication to mri including, but not limited to, patients with a pacemaker or defibrillator 3. patient diagnosed n1 during imaging workup or pn1 4. serum psa level ≥ 15 ng / ml 5. ipss score ≥ 15 or ipss score\> 7 if alpha blocking urological treatment in progress 6. prostate volume estimated on mri or ultrasound\> 90 cc 7. involvement of seminal vesicles on mri 8. history of cancer in the 5 years preceding entry into the trial 9. history of transurethral resection of the prostate less than 6 months compared to the expected date of start of radiotherapy 10. rectal surgery 11. pelvic irradiation 12. patient treated with antineoplastic or medication which may include methotrexate 13. hormone therapy started for more than 60 days at the time of inclusion 14. severe uncontrolled hypertension 15. patient followed or treated for severe or unstable angina, or having presented a myocardial infarction in the 6 months preceding the randomization 16. patient on immunosuppressant 17. patient with known hypersensitivity to gadoteric acid, meglumine or any drug containing gadolinium

Keywords: radiotherapy
stress & social cognition in borderline personality disorder

Conditions: Borderline Personality Disorder

Summary: the investigators will examine whether perceived social exclusion provoke a reduction in prosocial behavior in bpd patients.

the investigators will examine whether perceived social exclusion provoke a reduction in prosocial behavior, such as empathy, in bpd patients and whether this "fight-or-flight" pattern is also seen in other relevant aspects of social behavior, such as sharing and punishment behavior. to induce social exclusion all participants will play cyberball, either the exclusion condition or the (over)inclusion condition before testing

Eligibility criteria:
inclusion criteria: female patients with bpd and healthy control women, matched for age, body mass index, and education exclusion criteria: physical illness
nutritional management of infants with chronic diarrhea

Conditions: Growth and Tolerance Infant Study

Summary: the study objective is to assess the growth of infants fed an experimental formula for the nutritional management of chronic diarrhea.


Eligibility criteria:
inclusion criteria: * less than or equal to 12 months of age at enrollment * candidates for elemental feeding * chronic diarrhea and diagnosis of one of the following conditions: short-bowel syndrome, eosinophilic gastroenteritis, food allergy, inflammatory bowel disease, pancreatic disease, protein maldigestion, hiv-advanced disease or other gi disease requiring an elemental diet or have underlying gi disease without chronic diarrhea if his/her chronic diarrhea is controlled or is in remission by a semi-elemental or elemental formula for no more than 13 weeks * parents agree to feed infant with experimental formula for least 50% of total calories during study period exclusion criteria: * any non-approved concomitant study

Keywords: growth infants
indian phenotype registry

Conditions: Diabetes Mellitus

Summary: this study is a non-interventional, multicentre observational study to be conducted at 1000 sites in india. the study targets to enrol approx. 50000 patients with approx. 50 patients per site. the study would enrol diabetes mellitus patients who provides written informed consent. no study medication will be prescribed or administered as a part of study procedure. patients, who have been treated as per investigators' routine clinical practice will be screened for enrolment in study. the study will be initiated after obtaining written approval of independent ethics committee (iec) /institutional review board (irb).

this study is a non-interventional, multicentre observational study to be conducted at 1000 sites in india. the study targets to enrol approx. 50000 patients with approx. 50 patients per site. the study would enrol diabetes mellitus patients who provides written informed consent. no study medication will be prescribed or administered as a part of study procedure. patients, who have been treated as per investigators' routine clinical practice will be screened for enrolment in study. the study will be initiated after obtaining written approval of independent ethics committee (iec) /institutional review board (irb). this is a single visit cross sectional study however during site feasibility visit, probability of follow-up of these patients will be evaluated. if feasible protocol will be amended to continue data collection prospectively for appropriate duration

Eligibility criteria:
inclusion criteria 1. male or female patients with 18 years and above. 2. patients who provide written informed consent. 3. patients with previously diagnosed with diabetes mellitus 4. hba1c report available within past 3 months exclusion criteria- none

Keywords: diabetes, t2d
two pieces of fruit to type 2 diabetics?

Conditions: Diabetes Mellitus, Type 2

Summary: it has been questioned whether patients with type 2 diabetes who are advised to restrict their fruit consumption to two or less pieces of fruits daily have better outcomes (hba1c, body weight, fruit intake and serum lipids) after three months compared to patients with type 2 diabetes who are advised to eat at least two pieces of fruits. to the investigators' knowledge, no randomized controlled trial has evaluated this. the investigators therefore perform a randomized controlled trial including 76 patients with type 2 diabetes to investigate this. the investigators' hypothesis is that: type 2 diabetics who are advised to restrict their fruit consumption have the same hba1c three months after an initially dietary treatment as type 2 diabetics who are advised not to restrict their fruit consumption.


Eligibility criteria:
inclusion criteria: * patients refered from a general practitioner exclusion criteria: * no hba1c when refered * hba1c lower than 5% or higher than 12% * patients that require a translator * patients with severe cardiovascular, renal or endocrine disease * psychiatric patients * pregnant patients
use of the triggering receptor expressed on myeloid cells-1 (trem-1) in the diagnosis of pleural effusion

Conditions: Pleural Effusion

Summary: the aim of this trial is to evaluate the level of trem-1 in different kinds of pleural effusion.

the triggering receptor expressed on myeloid cells-1 (trem-1) is a member of the immunoglobulin superfamily, and its expression is upregulated on phagocytic cells in the presence of bacteria or fungi. several experiments by bouchon and colleagues showed that trem-1 mediates the acute inflammatory response to microbial products. human tissues infected with bacteria are infiltrated with neutrophils and macrophages that express high levels of trem-1. conversely, trem-1 is only weakly expressed in samples from patients with noninfectious inflammatory disorders. in addition, trem-1 is shed from the membrane of activated phagocytes and can be found in a soluble form in body fluids. the presence of a soluble form of trem-1 in samples of bronchoalveolar lavage fluid from mechanically ventilated patients has been shown to be a good indicator of infectious pneumonia.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of pleural effusion * pleural effusion proved by chest sonography exclusion criteria: * conditions for which thoracentesis are contraindicated * pregnancy

Keywords: pleural effusion trem-1
side-to-side duodenojejunostomy after distal duodenal resection (duoresect)

Conditions: Duodenal Neoplasm; Gastrointestinal Disease; Surgery--Complications; Survival

Summary: lower partial duodenectomy could be indicated in case of injury, wide neck diverticulum, tumor invasion by other tumors such as retroperitoneal sarcoma and primary tumor of 3rd and 4th portion of the duodenum. reconstruction after resection is usually performed by a end-to-end or end-to-side anastomosis. the investigators analyze the short and long-term results of a case series with resection for various lesions in the third and fourth duodenal portions and reconstruction of the intestinal transit through side-to-side duodenojejunostomy

the investigators retrospectively looked at patients who, from january 2010 to december 2018, underwent surgical procedures for duodenal tumors or other type of primary lesions. patients with primary duodenal lesions who underwent surgery were included in the study. patients with secondary duodenal infiltration or liver and/or peritoneal metastasis found during intraoperative exploration were excluded. similarly, if the surgeons appreciate the involvement of the pancreas during the procedure, for which they would have to perform a pancreaticoduodenectomy, the patient would be excluded. diagnostic management included establishment of a medical history, performance of clinical examination and imaging tests, including endoscopic exploration and, when neoplasm was suspected, computerized tomography (ct) scan, to confirm the tumor origin and growth, as well as infiltration, if any, of adjacent structures. these also allowed to rule out distant metastases, and to assess resectability and the option for reconstruction according to the location. the variables taken into account were age, sex, the american society of anesthesiologists (asa) classification, preoperative examinations performed and type of lesion susppected as benign, duodenal adenocarcinoma or gastrointestinal stromal tumor (gist). perioperative clinical results, surgical approach, type of resection and reconstruction, and intraoperative complications were recorded. details of the postoperative course were collected. some of the key short-term data recorded included length of hospital stay, complications' ranking (according to the clavien-dindo score; 'severe complication' is defined as greater or equal to iiia), re-operation, re-admission and operative mortality (\< 90 days after operation). some of the key long-term data recorded were, digestive symptoms along follow-up, specific disease-free survival (dfs) and overall survival (os)

Eligibility criteria:
inclusion criteria: * patients with primary duodenal lesions who underwent surgery exclusion criteria: * secondary duodenal infiltration or liver and/or peritoneal metastasis found during intraoperative exploration
molecular signatures of cutaneous squamous cell carcinoma during recessive dystrophic epidermolysis bullosa

Conditions: Recessive Dystrophic Epidermolysis Bullosa

Summary: recessive dystrophic epidermolysis bullosa (rdeb) is a hereditary skin disease characterized by cutaneous and mucosa fragility. blister formations and erosions, resulting in chronic wounds and dystrophic scars, lead development of aggressive cutaneous squamous cell carcinoma (cscc) in young subjects. cscc in rdeb patients are often recurrent and sometimes aggressive. although fibrotic and inflammatory microenvironment plays an important role in the tumoral process, specific mechanisms in cscc of rdeb patients are still unknown. actually, the only treatment is a wide surgical excision with poor prognostic (80% of death after the first occurrence of cscc). the objective of the study is to describe the molecular signatures in the cscc in rdeb patients


Eligibility criteria:
inclusion criteria: * for rdeb patients with a scc : 1. aged older than 18 years old 2. one or more scc surgically treated 3. signed genetic consent form * for non-rdeb patients with a scc induced by ultraviolet radiation : 1. aged older than 18 years old 2. one or more scc induced by ultraviolet radiation 3. signed genetic consent form exclusion criteria: * under protection by law (tutorship or curatorship) * without health insurance coverage
vestibular incision subperiosteal tunnel access (vista) technique versus coronally advanced flap (caf) combined with a connective tissue graft for the treatment of maxillary gingival recessions

Conditions: Gingival Recessions

Summary: gingival recession (gr) is a common oral health problem that causes sensitivity, esthetic concerns and hygiene problems. successful root coverage can be achieved by various surgical techniques. the vista technique may overcome some of the limitations of other techniques and present equal results to techniques that are considered the "gold standard" in this area of periodontology. the objective of the research is to study the vista technique in terms of complete root coverage, % root coverage, gingival thickness gain, bleeding on probing, keratinized gingival width, proms, vestibular depth and esthetic results.


Eligibility criteria:
inclusion criteria: * healthy adults: men and women between 18 and 75 years of age. * accepts and signs informed consent. * systemically healthy patients with periodontal health or controlled periodontitis. * presence of at least two maxillary cairo type i or ii (rt1/2) recessions \> 2 mm deep on buccal aspect. * plaque index ≤20% * no previous periodontal surgeries performed. * presence of the cementoenamel junction (cej), a 1 mm step in the cej and/or presence of root abrasion, but with an identifiable cej will be accepted. exclusion criteria: * smoker of 10 ≥ cigarettes per day. * contraindications to periodontal surgery. * medications that affect the gingiva or their healing. * active orthodontic treatment. * pregnant women * caries or restorations in the area to be treated. * patients who cannot follow the post-surgical medication adequately

Keywords: vista technique caf root coverage
stimulation of efferent loop prior to ileostomy closure

Conditions: Ileostomy; Complications

Summary: the aim of this study is to compare postoperative ileus between stimulated and unstimulated patients prior to ileostomy closure.

stimulation was performed ten days prior to the intervention, through the efferent limb of the ileostomy with 500 cc of a thickening substance (saline and nutritional thickener)

Eligibility criteria:
inclusion criteria: * protective ileostomy after rectal cancer surgery exclusion criteria: * under 18 years

Keywords: ileostomy closure,postoperative ileus,stimulation ileostomy
impact of body mass index on serum maternal and fetal magnesium level

Conditions: Pre-Eclampsia

Summary: magnesium sulphate is an inorganic salt with multiple therapeutic applications in medicine it has been widely utilized and studied on a diverse set of conditions such as asthma, cardiac arrhythmia and stroke. in pregnant women ,mgso4 has been used in many cases such as for seizures prophylaxis in preeclampsia, tocolysis in preterm labour and for fetal neuroprotection in immenint preterm delivery.mgso4 has been used as the standard drug for tocolysis in preterm labour and other drugs have been compared to it.


Eligibility criteria:
inclusion criteria: pregnant women 34 weeks or less admitted to women's health hospital with a diagnosis of : * sever preeclampsia. it is defined as 1- blood pressure 160/110 mmhg or more 2- proteinurea (+3 or more by dipstick) 3-hellp syndrome * threatened preterm labour that will receive magnesium sulphate either for tocolysis or neuroprotection. exclusion criteria: - women with more than 34 weeks gestation and with any contraindication for magnesium sulphate intake like severe renal impairment or myasthenia gravis.
resistance exercise, muscle mass, strength and body composition

Conditions: Sarcopenia; Obesity

Summary: a plethora of trials reported the positive effect of resistance exercise on functional and morphological parameters. although a large amount of the studies used suboptimum devices and obsolete methods the results of these older studies were still considered as golden standard. the aim of the present study is thus to determine the proper effect of different resistance exercise protocols with and without adjuvant protein supplementation on functional and morphological muscle and body composition parameters in male untrained subjects 30-50 years old under special regard of modern medical imaging and segmentation technologies. our general study hypothesis is that hit-resistance exercise significantly impact relevant muscular parameters of the upper leg.


Eligibility criteria:
inclusion criteria: * males * untrained (\< 2 h exercise/week, \< 1 h resistance exercise/week) * 30-50 years old exclusion criteria: * medication/diseases affecting intervention or study endpoints * history of intense resistance exercise (\> 3 h/week during the last decade) * very low physical capacity (\< 100 watt at ergometry) * more than 2 weeks of absence during the interventional period * contraindication related to mri-assessment (i.e. magnetizable intracorporal artefacts) * pathological changes of the heart * inflammable diseases

Keywords: resistance exercise muscle mass abdominal fat strength coronary heart disease (chd)-risk myocardial mass