Kornimate/medical-research-clean huggingface dataset:
virtual reality and laser biostimulation on pain perception and dental anxiety

Conditions: Dental Anxiety; Pain Intensity Assessment

Summary: dental anxiety in children can prevent planned treatment from being carried out, negatively affect the child's relationship with the dentist and make the treatment process difficult. the most common sources of directly anticipated anxiety are known to be associated with pain. painful experiences are anxiety-provoking for people of all ages, especially children.this study aims to evaluate the effect of virtual reality glassess (vr) and low-level laser therapy (lllt) on dental anxiety and pain perception during local anaesthesia administration in paediatric patients.

this study aims to investigate the combined effects of virtual reality glassess (vr) and low-level laser therapy (lllt) on dental anxiety and pain perception in paediatric patients undergoing local anaesthesia for dental procedures. dental anxiety is a common issue in children, often leading to increased pain perception and poor cooperation during treatment. virtual reality has been proposed as a distraction technique, while lllt is believed to reduce pain and inflammation. by exploring the effectiveness of these two interventions, the study seeks to determine whether vr and lllt can serve as effective adjuncts to improve patient comfort, reduce anxiety, and enhance overall treatment experience during the administration of local anaesthesia

Eligibility criteria:
inclusion criteria: * no history of systemic disease or infectious disease * compliant with the dental treatments to be performed in the children's dental hospital and able to answer the questions asked * exhibiting 'positive' and 'absolutely positive' behaviours during the examination, compliant according to the frankl scale, * children with no previous experience of dental treatment with local anaesthesia exclusion criteria: * children with any systemic condition * mentally and physically disabled, unable to co-operate, * children allergic to local anaesthesia, * previous dental treatment experience with local anaesthesia * exhibiting "negative" and "strongly negative" behaviour according to the frankl scale * children with eye diseases such as myopia and astigmatism

Keywords: pain perception dental anxiety children virtual reality dental laser
a study of ombitasvir/paritaprevir/ritonavir and dasabuvir with or without sofosbuvir and ribavirin in direct-acting antiviral agent treatment-experienced adults with chronic hepatitis c virus infection

Conditions: Chronic Hepatitis C Infection

Summary: the purpose of this study is to evaluate the safety and efficacy of ombitasvir/paritaprevir/ritonavir and dasabuvir with or without sofosbuvir (sof) and ribavirin (rbv) in daa treatment-experienced adults with genotype 1 chronic hepatitis c virus infection. this study will contain 2 parts. part 1: approximately 20 participants and at least 10 of the 20 participants previously treated with the combination of ombitasvir/paritaprevir/ritonavir and dasabuvir, with or without rbv, and experienced treatment failure. part 2: approximately 10 participants and all participants previously treated with sof/ledipasvir and experienced treatment failure.

efficacy, safety, and demographic analyses were performed separately for the 2 study parts using the intent-to-treat (itt) population, which consists of all enrolled participants who received at least one dose of study drug.

Eligibility criteria:
inclusion criteria: * history of previous direct acting antiviral (daa) therapy failure; part 2 only: history of previous direct acting antiviral (daa) therapy failure and received at least 8 weeks of sof/ledipasvir; participant must be treatment naïve to all other anti-hcv therapies * hcv genotype 1 infection * females must be post-menopausal, of non-child bearing potential or practicing specific forms of birth control exclusion criteria: * positive screen for hepatitis b surface antigen or anti-human immunodeficiency virus antibody * discontinuation of the prior daa treatment for reasons other than virologic failure * confirmed presence of hepatocellular carcinoma * abnormal lab tests

Keywords: hepatitis c interferon-free treatment experienced chronic hepatitis c hepatitis c virus
a comparison of the perioperative hemodynamic effects of remifentanil and esmolol in intracranial surgery

Conditions: Tachycardia; Hypertension; Myocardial Ischemia

Summary: it was hypothesized that the use of esmolol as an alternative to remifentanil with sevoflurane inhalation anesthesia during intracranial surgery, could provide better hemodynamic conditions and cause lesser side effects in the perioperative period. it was the main objective of this study to compare the effect of esmolol and remifentanil on the incidence of tachycardia and hypertension and the intraoperative fentanyl consumption. the comparison of postoperative troponine i and creatine phosphokinase levels and ekg changes were the secondary objectives.

during neurosurgical procedures intubation, insertion of the head pins, extubation and the early postoperative period are the time lines in which cerebral autoregulation can be impaired by changes in heart rate and blood pressure. several anesthetic regimens have been implied to overcome this problem. remifentanil is used in neurosurgery since it allows early recovery and neurologic evaluation. esmolol on the other hand is also very short acting, effective to blunt cardiovascular responses during surgery and has no significant effect on intracranial pressure and cerebral blood flow. in addition esmolol is addressed to reduce perioperative ischemia during noncardiac surgery. it was hypothesized that the use of esmolol as an alternative to remifentanil with sevoflurane inhalation anesthesia during intracranial surgery, could provide better hemodynamic conditions and cause lesser side effects in the perioperative period. it was the main objective of this study to compare the effect of esmolol and remifentanil on the incidence of tachycardia and hypertension and the intraoperative fentanyl consumption. the comparison of postoperative troponine i and creatine phosphokinase levels and ekg changes were the secondary objectives.

Eligibility criteria:
inclusion criteria: * intracranial surgery exclusion criteria: * heart rate ≤ 50, * atrioventricular block, * sick sinus syndrome, * heart failure, * history of asthma, * hypertension, * impaired renal or hepatic function, * patients receiving beta blockers or calcium channel blockers, * emergency surgery.

Keywords: remifentanil esmolol intracranial surgery heart rate blood pressure
characterisation of the biochemical profile and physiology of the coronary circulation in takotsubo syndrome

Conditions: Tako Tsubo Cardiomyopathy

Summary: consecutive consenting patients over the age of 18 years diagnosed with takotsubo syndrome according to the position statement of the european journal of heart failure (2016) will be included in the study. the primary endpoint is to evaluate the incidence of coronary microcirculation dysfunction and its correlation with the clinical presentation and the prognosis in patients with tako-tsubo syndrome. secondary endpoints will be to assess the incidence of in-hospital mortality, the prevalence of cardiogenic shock, the correlation between the levels of biomarkers analyzed, microvascular dysfunction, perceived quality of life, and angina severity during hospitalization and at subsequent follow-ups, and the influence of knowledge of the level of microvascular dysfunction on clinical management and prescribed therapies. enrolment: 2 years, follow-up: 1 month and 1 year. total: 3 years.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years; * diagnosis of takotsubo syndrome * signing of informed consent exclusion criteria: * age \<18 years; * refusal to sign written informed consent.
stool transplant to control treatment-related diarrhea

Conditions: Fecal Microbiota Transplantation (FMT)

Summary: this study will test the safety, effectiveness, and feasibility of a treatment called fecal microbiota transplantation (fmt) to reduce the symptoms of ici-related diarrhea. fmt uses a liquid preparation of stool collected from a healthy donor with normal (healthy) bacteria; this liquid is infused into the small or large intestine of a recipient during a colonoscopy procedure. the study researchers think that the healthy bacteria in the transplanted stool will grow and replace the unhealthy bacteria and return the intestines and colon of the recipient to a healthy state.


Eligibility criteria:
inclusion criteria: * ≥ 18 years old * patient has been treated with immune checkpoint inhibitors (ici), including anti-ctla-4, anti-pd-1 and anti-pdl-1 therapy for any malignant indication * patient has developed diarrhea ≥ grade 2 attributed to ici * patient has diarrhea ≥ grade 2 attributed to ici, that persists despite treatment with corticosteroids for at least 72 hours and/or at least one dose of a biologic medication, such as infliximab or vedolizumab, with symptoms that persist or recur at least 72 hours post-infusion ° if no to the above, patient has a contraindictation to immunosuppressive treatment exclusion criteria: * active gi infection, including untreated viral, bacterial or fungal or alternative identified cause(s) of diarrhea. * antibiotic exposure within 48 hours prior to fmt * expected prolonged compromised immunity indicated by at least one of the below: * known hiv infection with cd4 count \<240 * anc \<1000/mm3 (use of growth factors to raise anc is acceptable) * seronegative for ebv or cmv (i.e. ebv igg negative or cmv igg negative) * contraindications to anesthesia for procedure indicated by at least one of the below: * serious cardiopulmonary comorbidities * inability to tolerate anesthesia * pregnancy * patient is pregnant * women of childbearing potential should not have plans to became pregnant or breastfeed an infant and must agree to use a highly effective method of birth control until 2 months after treatment with fmt (e.g. barrier method, oral or parenteral contraceptives, a vasectomized partner, or abstinence from sexual intercourse) * severe food allergies

Keywords: immune checkpoint inhibitor (ici)-related diarrhea 20-242
optimisation strategy for emergency tracheal intubation

Conditions: Emergencies; Out-of-hospital Setting; Tracheal Intubation

Summary: this study has to objective to assess, in adults' patients needing tracheal intubation because of vital distress, the effect of a combined strategy to reduce intubation-related morbidity. this strategy will associate systematic use of rocuronium as paralyzing agent to facilitate tracheal intubation, bag face-mask ventilation before intubation and gum elastic bougie (geb) use.

several studies have reported positive impact of some interventions on the tracheal intubation-related complications incidence. providing bag face-mask ventilation between medication administration and initiation of laryngoscopy significantly reduced the number of peri intubation hypoxemia episodes. the use of a non-depolarizing (rocuronium) paralytic agent instead of succinylcholine is associated with less post-intubation complications occurrence. finally, use of a tracheal tube introducer (geb) as an aid for intubation in emergency patients with at least one prognostic factor of difficult laryngoscopy has been shown to facilitate intubation. assessment of a strategy combining these three interventions to reduce intubation related morbidity in emergency situations has never been assessed. it is expected that the combination of these interventions will drastically reduce the morbidity associated with emergency intubation. the strategy assessed will associate rocuronium use as paralyzing agent to facilitate intubation, bag mask ventilation before intubation and geb use at first intubation attempt in all patients. the emergency physician in charge of the patients will record out-of hospital outcomes immediately after the out-of-hospital period. intra-hospital data will be retrieved from the patient's medical record on the 28th day after inclusion.

Eligibility criteria:
inclusion criteria: * patient adult (≥ 18 years) presenting with vital distress requiring emergency tracheal intubation as assessed by the emergency physician in the out-of-hospital setting. * patient with all conditions (trauma, dyspnea, coma, overdoses, and shock) except those in cardiac arrest will be included. exclusion criteria: * patient presenting of a contraindication to succinylcholine, and/or rocuronium, and/or sugammadex (rocunorium antagonist). * patient who have contraindication to bag face mask ventilation before intubation (ongoing emesis, hematemesis, or hemoptysis). * patient that are not members of a medical aid scheme (beneficiary or main member). * patient under specific protection measures: pregnant, parturient or nursing women; legal protection or deprived of liberty: patient under judicial protection, patient under guardianship/curatorship.

Keywords: out-of-hospital intubation complications vital distress rapid sequence intubation rocuronium gum elastic bougie
postural perturbations tracing to the stomatognathic system

Conditions: Posture

Summary: a connection of the stomatognathic system \[an anatomical system comprising the teeth, jaws, and associated soft tissues\] to postural control has been suggested in the literature. this research will investigate how occlusion can impact postural response, disorder, and rehabilitation by examining how modifications in the vertical dimension of occlusion (vdo) influence balance and gait. although it is currently unclear which or how restorative approaches cause postural disturbances, changes in several occlusal factors, i.e. vdo, angle's class, crossbite and others have been suggested to manifest clearly into an altered stability, which could have a significant effect on the quality of life, especially in the elderly. the present study aims to identify the degree to which specific interventions in oral cavity affect the stability and gait patterns of patients, this will b achieved by either: * the use of dental splints (fully certified devices) * the use of the subjects' own dentures a direct correlation of postural perturbations and vdo, would essentially void the necessity to evaluate specific interventions (e.g. different types of restorations) independently and allow clinicians to assess a potential effect on their patients' stability and gait based on pre- to post- treatment vdo.


Eligibility criteria:
inclusion criteria for group a * 30-45 years old * physically and cognitively healthy (able to easily walk without assistance) * possessing a complete set of teeth (either natural or restored with crowns) * classified as class i malocclusion according to angle's criteria. inclusion criteria for group b * 50-65 years old * physically and cognitively healthy (able to easily walk without assistance) * fully edentulous * wear complete dentures exclusion criteria: * parkinson's disease * morbid obesity i.e. bmi values exceeding 40, calculated based on body weight and height requested over the phone or during the visit * occlusion altered due to a non-physiological condition i.e. trauma or pathology * active temporomandibular joint disorder * pregnancy, as pregnancy-related physiological changes could influence the study's balance and gait measurements. this exclusion will be based on self-report during the screening process, and no additional testing will be conducted. * any other condition that in the opinion of the study researchers has potential to impact balance or gait

Keywords: dental splints dentures vertical dimension of occlusion temporomandibular joint disorders balance gait
a study of non-small cell lung cancer (nsclc) patients receiving second-line nivolumab monotherapy in asia

Conditions: Lung Cancer; Non-Small Cell Lung Cancer

Summary: the purpose of this study is to investigate the safety of patients in asia with non-small cell lung cancer (nsclc)who are treated with nivolumab monotherapy as a second line or third line treatment.


Eligibility criteria:
for more information regarding bristol-myers squibb clinical trial participation, please visit www.bmsstudyconnect.com inclusion criteria: * advanced metastatic stage iiib/iv nsclc (nonsquamous and squamous) * 1 to 2 prior systemic therapies * eastern cooperative oncology group (ecog) performance status of less than or equal to 1 * participants must have measurable disease by computed tomography (ct) or magnetic resonance imaging (mri) * prior radiotherapy or radiosurgery must have been completed at least 2 weeks prior to starting study treatment exclusion criteria: * women with a positive pregnancy test at enrollment or prior to administration of study medication * participants with active central nervous system metastases * participants with a condition requiring systemic treatment with either corticosteroids (\> 10 mg daily prednisone equivalent) or other immunosuppressive medications within 14 days of first dose of study drug * participants with previous malignancies are excluded unless a complete remission was achieved at least 2 years prior to study entry and no additional therapy is required or anticipated to be required during the study period * participants with carcinomatous meningitis other protocol defined inclusion/exclusion criteria could apply
effects and mechanism of the sequential combination of exercise and cognitive training in stroke patients

Conditions: Stroke Patients With Cognitive Decline

Summary: the purpose of this study is to determine the treatment effects of sequential combination of aerobic exercise and cognitive training on cognitive function, physiological markers, daily function, physical function, social participation and quality of life in stroke patients with cognitive decline.

cognitive decline after stroke is a common sequela and is highly associated with functional disability. empirical evidence shows that exercise combined cognitive training may induce neuroplastic changes that modulate cognitive function. however, evidence about the effects of combined exercise-cognitive trainings on physiological biomarkers, cognitive and physical functions in stroke patients with cognitive decline is still less. the present study aim to investigate the effects of sequential combination of exercise-cognitive trainings on cognitive, physical, and daily function. in addition, the physiological mechanism of the combination training on cognitive function by several biomarkers including the brain-derived neurotrophic factor (bdnf), antioxidative marker, hba1c, and plasma lipid level will be investigated. this study is a single-blind randomized controlled trial. participants will be randomly assigned to seq group in which sequentially perform physical exercise and cognitive training or to ci group of control intervention.

Eligibility criteria:
inclusion criteria: 1. ischemic or hemorrhagic stroke occurring at least 6 months prior to enrollment 2. mmse score ≥ 19,moca\<26,able to follow the study instruction 3. self- or informant-reported memory or cognitive complaints or cdr scale ≤ 0.5 4. adequate cardiopulmonary function to perform aerobic exercise 5. able to walk with or without assistive devices exclusion criteria: 1. unstable medical history (e.g., recent myocardial infarction) that might limit participation 2. concomitant with other neurological disorders (e.g., parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis) 3. current participation in another interventional trial
effect of preoperative oral carbohydrate administration in thoracic surgery patients

Conditions: Non Small Cell Lung Cancer; Fasting; Postoperative Pneumonia

Summary: preoperative carbohydrate loading has been shown to reduce pre-operative discomfort and postoperative nausea and vomiting. there is no need for prolonged preoperative fasting of the patients, but the traditional approach still continues especially in thoracic surgery patients. for this purpose, we aimed to evaluate the effect of preoperative carbohydrate loading on postoperative morbidity in the patients.

the study was conducted on 94 patients. the patients in the control group were fasting after midnight. experimental group patients consumed carbohydrate drink as liquid two hours before the operation. 47 patients were in the control group (a) and 47 patients were in the experimental group (b). the groups were compared in terms of length of hospital and intensive care unit stay, vomiting, gas-stool outlet, postoperative pain conditions (vas), inflammation parameters, blood glucose, and mobilization time. spss 11.0 (spss, inc., chicago, il, usa) was used for statistical analyses. all means were presented with 95% confidence limits. in the empirical analysis, t-test and chi-square test were used. in addition, correlation analysis was used to determine the relationship between fasting time and surgical recovery time.

Eligibility criteria:
inclusion criteria: stage i-stage ii all operable nsclc patients - exclusion criteria: patients with diabetes mellitus, a history of delayed gastric emptying, severe hepatic or renal failure, or any endocrine disorder that might influence the metabolic parameters were excluded, as were patients requiring urgent or emergent surgery. -

Keywords: preoperative fasting, postoperative morbidity, preoperative carbohydrate drinking, thoracic surgery
internet-based self-help for tinnitus: the role of support

Conditions: Tinnitus

Summary: internet-based cognitive behavioural self-help (icbt) has become increasingly popular to provide psychotherapy. for several psychological and psychosomatic disorders, treatment efficacy was shown. previously, icbt has also been applied to patients suffering from tinnitus and results show significant and long-term stable improvements in tinnitus distress. however, the role of therapeutic support in icbt has not been thoroughly investigated. previous results suggest that icbt without therapeutic support is less effective and leads to higher dropout rates than therapist-guided icbt. the aim of the randomized controlled trial is thus to investigate the role of therapeutic support in an icbt for tinnitus sufferers.


Eligibility criteria:
inclusion criteria: * tinnitus duration of more than 6 months * severe or most severe tinnitus distress * age of at least 18 years * fluent in german exclusion criteria: * psychosis, severe psychological disorder, risk for suicide * prior participation in associated study * medical disorder as reason for tinnitus, i.e. morbus ménière

Keywords: tinnitus cognitive behavioural therapy internet treatment