Kornimate/medical-research-clean huggingface dataset:
identification and prevention of pelvic floor dysfunction in gynecologic cancer survivors

Conditions: Gynecologic Cancer

Summary: the two goals of this study are to establish a standardized method of assessing the pelvic floor for patients undergoing pelvic radiation and to determine the feasibility of inverse-rt planning using mri to identify dosimetric constraints of the pelvic floor musculature for use in radiation planning. the investigators hypothesize that an exam-based diagnostic tool will provide more information about the areas of injury related to pelvic radiation than patient-reported outcomes, and could be used in future studies of preventive strategies. an exam-based tool will also allow measurement of the pain dose-response to radiation treatment of specific areas, which could be excluded from radiation fields during treatment planning.


Eligibility criteria:
inclusion criteria - prospective cohort * undergoing primary treatment for locally advanced cervical cancer with definitive, curative-intent chemoradiotherapy (chemotherapy must be a radiosensitizing platinum agent). * at least 18 years of age. * english speaker. * able to understand and willing to sign an irb approved written informed consent document. exclusion criteria - prospective cohort * received any form of pelvic radiation (excepting diagnostic studies). * currently taking and does not plan to take anti-estrogenic hormonal therapy. * diagnosis of interstitial cystitis/chronic bladder pain, irritable bowel syndrome, or inflammatory bowel disease. * currently being treated for a chronic non-cancer pain condition (treatment for pain after enrollment is acceptable). inclusion criteria - retrospective cohort (historical control) * received primary treatment for locally advanced cervical cancer with definitive, curative-intent chemoradiotherapy (chemotherapy must be a radiosensitizing platinum agent). * at least 18 years of age. exclusion criteria - retrospective cohort (historical control) * received any form of pelvic radiation (excepting diagnostic studies). * took anti-estrogenic hormonal therapy during treatment or in the 6 months following treatment. * diagnosis of interstitial cystitis/chronic bladder pain, irritable bowel syndrome, or inflammatory bowel disease at the start of treatment. * simultaneously treated for a chronic non-cancer pain condition at the start of treatment.

Keywords: cervical cancer radiation chemoradiation pelvic floor muscle dysfunction chronic pelvic pain
record voxel rate nonlinear optical microscope to unravel brain connectome and signaling

Conditions: Brain Tumor; Brain Cancer

Summary: the research aims to develop a novel pathological technology, including rapid whole-mount tissue h\&e \& ihc staining protocol and high-resolution nonlinear optical microscopy imaging system, to intraoperatively assess brain tumor grade, types and other biological parameters.

brain tumors, especially like glioma, the infiltrative growth pattern resulted in an indistinct margin against normal brain tissues. surgery is currently the most effective method in prolonging patient's survival, the extent of tumor resection is therefore crucial to the overall outcome. distinguishing the tumor type and grading can help neurosurgeons plan the intraoperative surgical strategies to cure the suffered patients. feasible solutions to improve the extent of resections including fluorescence-guided surgery and intraoperative mr imaging are relatively indirect to judge the completeness of tumor resection and its margin; considering means like moh's surgery performed in the dermatological practice, though it is reasonable to look at the resection proportion by pathological interpretation, it is very time consuming. besides, many kinds of brain tumors can't be classified only by the outcomes of frozen pathology. there are several related studies trying to solve the problem, but the judgment criteria is not sufficient to meet the standard of modern pathological diagnosis. the research aims to acquire images by optical microscopy from both h\&e and ihc stained tissues, and to compare those images with slides obtained by standard pathological workflow in order to achieve accurate and rapid assessment of tumor categories and grading.

Eligibility criteria:
inclusion criteria: 1. patients older than the age of 20 with diagnosis of brain tumor (both newly-diagnosed or recurrent) who are suitable and willing to receive resection surgery. exclusion criteria: 1. patients who cannot give consent to participate in the study. 2. the tumor samples failed to give a conclusive pathological diagnosis by standard pathological workflow. 3. patients who only receives biopsy surgery rather than resection surgery. 4. significant post-irradiation effect or radiation necrosis reported in the pathological examination.

Keywords: brain tumor brain cancer
circulating tumor mitochondrial dna (ct-mtdna) as a biomarker for hepatocellular carcinoma recurrence surveillance

Conditions: Hepatocellular Carcinoma (HCC)

Summary: this is a prospective, observational, single-center study. the purpose of this study is to evaluate the efficacy of circulating tumor mitochondrial dna (ct-mtdna) in plasma as a biomarker for minimal residual disease (mrd) assessment and recurrence monitoring in patients with hepatocellular carcinoma.

hepatocellular carcinoma (hcc) is a leading cause of cancer-related mortality worldwide, with a significant proportion of cases occurring in china. despite advancements in treatment, the prognosis for hcc remains poor due to late diagnosis and high recurrence rates. minimal residual disease (mrd) refers to the presence of residual cancer cells after treatment, which can lead to tumor recurrence. the primary objective of this study is to evaluate the effectiveness of plasma tumor mitochondrial mutations as a biomarker for mrd assessment and recurrence monitoring in patients with hcc. the study hypothesizes that the presence and dynamics of tumor mitochondrial mutations in plasma are associated with the risk of recurrence and overall survival in hcc patients. this is a prospective, observational, single-center study conducted by the chinese cooperative group of liver cancer (ccglc) under the auspices of the chinese chapter of international hepato-pancreato biliary association. the study will involve the collection and analysis of plasma samples from patients with hcc to detect ct-mtdna mutations before and after treatment. the primary clinical endpoint is the impact of mrd status on progression-free survival (pfs). secondary endpoints include the influence of treatment on mrd markers, the correlation between post-treatment residual tumor molecular burden and pfs, and the ability of mrd detection to predict recurrence earlier than traditional tumor markers or imaging methods. this study seeks to contribute to the field of hcc management by providing a more precise and personalized approach to mrd assessment and recurrence monitoring. the findings have the potential to improve long-term treatment outcomes and quality of life for patients with hcc.

Eligibility criteria:
inclusion criteria: * patients with hepatocellular carcinoma (hcc); * diagnosis of hcc is according to the american association for the study of liver diseases or european association for the study of the liver guidelines of hcc management; * at least one measurable lesion according to response evaluation criteria in solid tumors (recist) v1.1 or mresist criteria.; * expected survival time of 12 weeks or more; * signed informed consent form and ability to comply with the study visits and related procedures as stipulated in the protocol. exclusion criteria: * patients with other active tumors or severe complications; * insufficient tumor tissue for mrd detection.

Keywords: mrd ct-mtdna recurrence hepatocellular carcinoma
a multicentric validation study on the accuracy of artificial intelligence assisted system in clinical application of digestive endoscopy

Conditions: Gastrointestinal Disease; Endoscopy; Artificial Intelligence

Summary: this is an artificial intelligence-based optical artificial intelligence assisted system that can assist endoscopists in improving the quality of endoscopy.

endoscopic diagnosis and treatment play an important role in the discovery and treatment of gastrointestinal diseases.with the rapid increase in the number of endoscopies, the workload of endoscopists increases further.the high workload reduces the quality of endoscopy, leading to incomplete coverage and incomplete detection of lesions.with the rapid increase in the number of endoscopies, the workload of endoscopists increases further.the high workload reduces the quality of endoscopy, leading to incomplete coverage and incomplete detection of lesions.therefore, carrying out deep learning and other artificial intelligence methods has good academic research and practical value for improving the quality of endoscopic diagnosis and treatment.the research and development, testing and functional evaluation of artificial intelligence devices need to use a large number of endoscopic images, and at the same time, the effectiveness and safety of artificial intelligence devices need to be verified in different hospitals and environments.based on this, our research group intends to collect endoscopic image data from different hospitals for training and validation of the model.

Eligibility criteria:
inclusion criteria: 1. male or female aged 18 or above; 2. endoscopy and related examinations should be performed to further clarify the characteristics of digestive tract diseases; 3. be able to read, understand and sign the informed consent; 4. the researcher believes that the subject can understand the process of the clinical study, is willing and able to complete all the study procedures and follow-up visits, and cooperate with the study procedures; exclusion criteria: 1. have participated in other clinical trials, signed the informed consent and have been in the follow-up period of other clinical trials; 2. drug or alcohol abuse or psychological disorder in the last 5 years; 3. pregnant or nursing women; 4. subjects with previous history of gastrointestinal surgery; 5. the researcher considers that the subject is not suitable for endoscopy and related examination; 6. high-risk diseases or other special conditions that the investigator considers inappropriate for the subject to participate in the clinical trial.

Keywords: deep learning
study of daclatasvir-based therapy in chinese participants with chronic hepatitis c (chc)

Conditions: Chronic Hepatitis C

Summary: study is a non-interventional, prospective, multicenter post marketing surveillance study to determine the safety of daclatasvir based therapy


Eligibility criteria:
inclusion criteria: * participants 18 years of age and older * participants with chronic hepatitis c virus (chc) who are eligible for treatment with branded dcv-based therapy as indicated in the locally approved label exclusion criteria: * participants under the age of 18 other protocol defined inclusion/exclusion criteria could apply
an outpatient study of the effectiveness and safety of depakote er in the treatment of mania/bipolar disorder in children and adolescents

Conditions: Bipolar Disorder

Summary: the purpose of this study is to determine the safety and effectiveness of depakote er (divalproex sodium extended-release tablets) compared to placebo in the treatment of bipolar disorder, manic or mixed type in children and adolescents ages 10-17 years.


Eligibility criteria:
inclusion criteria * current primary diagnosis of bipolar i disorder, mania or mixed type * outpatient between 10 and 17 years of age * young mania rating scale score greater than or equal to 20 during screening/washout and at day 1 exclusion criteria * axis i other than attention deficit hyperactivity disorder (adhd), obsessive compulsive disorder (ocd), oppositional defiant disorder (odd), conduct disorder (cd), panic disorder; or axis ii (e.g., personality disorder) that would interfere with compliance or confound interpretation of study results * current manic episode is drug-induced or secondary to a medical disorder (e.g., anti-depressants, hyperthyroidism) * expected to require hospitalization for the current manic episode * participation in psychotherapy that was started within the past 3 months, or if any significant changes are anticipated * has taken atomoxetine or has taken allowed stimulant medication that has not been stable for at least 3 months prior to day 1, or a dosage adjustment is expected during the study, or that may worsen mood symptoms * unable to swallow tablets * has received depot psychoactive medication within one inter-injection interval of day 1 * urine toxicology screen is positive for phencyclidine (pcp), opiates, cocaine, barbiturates, benzodiazepines or amphetamines * history of alcohol or substance dependence within past 3 mos. or substance abuse within past month * history of failed treatment on adequate depakote (dr or er) for a manic episode within past 12 months * has taken depakote (dr or er) regularly for the current manic episode * has serious violent, homicidal, or suicidal ideation

Keywords: bipolar disorder type 1 (manic or mixed type)
investigation of the effects of inspiratory muscle training on patients with mechanical low back pain.

Conditions: Mechanical Low Back Pain

Summary: there are many conservative treatment methods for the treatment of mechanical low back pain and they continue to be developed. the aim of this study is to examine the effects of inspiratory muscle training, which can be added to these treatment methods, on muscle endurance, functional capacity, pain intensity, disability, quality of life and sleep quality in people with mechanical low back pain.

when initial assessment will be completed, patients will be assigned to one of two possible sequences by simple randomization: study group (sg) or control group (cg). all participants will receive the core stabilization exercise program designed for mechanical low back pain for 8 weeks. additionally, the study group will receive inspiratory muscle training for 8 weeks. all studies will be evaluated both at the beginning and end of the study in terms of pain, quality of life, sleep quality, disability level, muscle endurance and functional capacity. all data will be collected by the same physiotherapist at baseline and at the end of the study (8 weeks). the same physiotherapist will also supervise the exercises and inspiratory training.

Eligibility criteria:
inclusion criteria: * to be between the ages of 18-65 * applying to the physical therapy unit with the diagnosis of mechanical low back pain (lumbal disc herniation, spinal stenosis, spondylolisthesis, facet joint pain, discogenic pain, sacroiliac joint pain, myofascial pain, lumbar osteoarthrosis) * ability to adapt to exercise commands and understand assessment questions * volunteering to participate in research exclusion criteria: * those with cooperation and communication problems * complaining of acute or chronic musculoskeletal pain other than low back pain * having a chronic disease (hypertension, diabetes, chronic obstructive pulmonary disease (copd), previous cerebrovascular accident (cvo), heart, neurological and rheumatological problems) * sequestrated and extruded hernia * receiving physical therapy in the last 2 months * having a history of recent surgery (spine, abdomen, upper and lower extremity surgeries) * being obese (body mass index ≥30 kg/m2) * contagious and vascular diseases

Keywords: mechanical low back pain inspiratuar muscle training core stabilization exercise
serotonin effect in functional dyspepsia

Conditions: Dyspepsia

Summary: the purpose of this study is to investigate whether efexor (venlafaxine) is effective in the treatment of functional dyspepsia.

background: a good 60% of patients presenting with upper abdominal complaints have functional dyspepsia. usually, acid-suppressive drugs are given as first-line therapy for upper gastrointestinal symptoms. however, results are often not satisfying and symptoms persist. since many patients with functional gastrointestinal diseases are more anxious and depressed in comparison to healthy controls, several studies investigated the use of antidepressant agents in these patients. although many studies were underpowered, promising results were obtained with tricyclic antidepressant and mianserin in patients with irritable bowel syndrome. there is still a need for a placebo controlled study with antidepressants in patients with functional dyspepsia. objective: to investigate the effectiveness of venlafaxine, a selective serotonin and norepinephrine reuptake inhibitor, for treatment of patients with functional dyspepsia. study design: a randomized, double blind, placebo controlled trial. study population: consecutive patients with persistent upper gi symptoms without abnormalities at upper gastrointestinal endoscopy. primary endpoints: upper gastrointestinal symptom absence after 6 weeks treatment. secondary endpoints: * anxiety and depression after venlafaxine treatment; * health related quality of life after venlafaxine treatment; * the association between serotonin transporter protein and 5-ht receptor polymorphisms and efficacy of venlafaxine. study procedure: a venous blood sample will be collected in a 10ml edta-tube. then, each subject will be randomized to treatment with efexor xr (first and last two weeks 75 mg 1dd and from the third to the fifth week 75 mg 2dd) or identical placebos for 8 weeks. before starting and after finishing treatment, patients will be asked to fill out a questionnaire on intensity of their gastrointestinal complaints, current quality of life and anxiety and depression.

Eligibility criteria:
inclusion criteria: * persistent upper gastrointestinal symptoms; * absence of any serious organic cause of the complaints at previous upper gastrointestinal endoscopy (including gastric ulcer, carcinoma, oesophageal reflux disease, portal hypertension, hernia hiatus \>2 cm or severe gastritis); * over 18 years of age; * written informed consent. exclusion criteria: * history of bipolar disorder; * contra-indication for venlafaxine; * current or planned pregnancy or lactation; * diagnosed alcoholism, anorexia nervosa or bulimia; * current or recent (within the last two weeks) use of a selective serotonin re-uptake inhibitor (ssri) or mao-inhibitor; * any other condition or circumstance that, in the opinion of the investigator or the physician, would compromise the subject's successful participation in this trial.

Keywords: functional dyspepsia; serotonin uptake inhibitors; antidepressive agents.
clinical impact of 2 types of mandibular retention devices - narval o.r.m cadcam design vs narval o.r.m traditional design - on obstructive sleep apnea (osa) therapy: estamps study

Conditions: Obstructive Sleep Apnea Syndrome

Summary: estamps is a randomized clinical trial with a crossover design: main objective is to compare impact of 2 different mandibular retention device (mrd) designs (narval mrd cadcam (cc) design vs narval mrd traditional (trad) design) on upper airway volume secondary objectives: to evaluate the maximal mandibular propulsion according to the type of mrd to evaluate benefits on quality of life, sleepiness and osa symptoms to evaluate impact of mrd design on therapy efficacy and tolerance to evaluate impact of mrd design on mandibular positioning

hypothesis orcades results suggest that narval o.r.m cc could be more efficient than narval mrd trad to reduce ahi whatever the initial osa severity 79% of cc mrd patients have at least an ahi reduction of 50% (vs. 61% with a trad narval mrd, p=0.0031) 66% of cc mrd patients get a complete answer with an ahi reduction \<10 (vs. 49% with a trad narval mrd, p=0.0017) the investigators think that differences seen in the orcades study between the 2 mrd is due to a different impact on upper airway volume

Eligibility criteria:
inclusion criteria: * patients with a mild osa syndrome (5\ 15) who do not tolerate or refuse cpap therapy * patients ≥ 18 years old * patient is able to fully understand study information and provide written informed consent exclusion criteria: * mrd contraindication * clinical trial classic exclusion criteria

Keywords: obstructive sleep apnea syndrome mandibular repositioning device
role of bandage after fue hair transplantation

Conditions: Hair Loss/Baldness

Summary: the aim of this interventional study is to determine the role of bandage on the follicular donor sites on the scalp after fue hair transplantation. a randomized side of the scalp will be covered using bandage, the other side will be left naked. subjects under study will be evaluated after the procedure is completed, and day 1 and day 7 post-procedure during the healing phase. this will in turn help, answering the importance of bandage in healing of the donor site post-hair transplantation.

in this modern era, hair-transplantation has become very common. interests in wound healing is not new; with every passing day, different techniques are introduced to get better results for the patients. the current literature available online shows that many hair-transplant centers have stated about using bandage on the donor area post-transplantation, however, there isn't a single study available to augment this use of bandage. on the other hand, data regarding application of antibiotic ointments and silicon gels is available. the punctures made during fue are only of 9-10mm, requiring no sutures. in addition to this, the blood supply of the scalp also favors quick healing. the process of re-epithelization starts within a few hours of injury and progresses over the first 1 to 3 days. most of the clinics remove, the bandage after 24hrs, disrupting the healing process of the skin. in the present study, the investigators sought to compare bandage versus no-bandage donor site in terms of healing. the investigators hypothesize that, compared with bandage site, no-bandage donor site after fue will have reduce post-procedural downtime and donor site inflammation ultimately, enhancing patient satisfaction with the procedure. the long-term goal of this study is to get evidence-based usage of bandage, if results are in contrast with the hypothesis.

Eligibility criteria:
inclusion criteria: * over 18 years old * able to provide informed consent * planning to undergo follicular unit extraction hair restoration exclusion criteria: * significant medical or surgical conditions * unable to give informed consent * immunocompromised

Keywords: hair loss follicular unit extraction hair transplantation wound healing
intraabdominal pressure monitoring urinary catheter and kidney perfusion pressure

Conditions: Acute Kidney Injury

Summary: the goal of this clinical trial is to determine whether monitoring intra-abdominal pressure (iap) and adjusting blood pressure accordingly to maintain optimal renal perfusion pressure can reduce the risk of acute kidney injury (aki) after cardiac surgery. the main question this study aims to answer is: - does iap-guided blood pressure management improve renal perfusion and lower aki rates in cardiac surgery patients? participants will be randomly assigned to one of two groups: * control group: standard icu care with a conventional foley catheter. * intervention group: standard icu care with an iap-monitoring foley catheter, where blood pressure is adjusted based on iap readings to optimize renal perfusion pressure. all participants will undergo routine blood and urine tests to assess kidney function during their hospital stay. this study will help determine whether iap-based hemodynamic management can improve postoperative kidney outcomes and provide a new strategy for aki prevention in cardiac surgery patients.


Eligibility criteria:
inclusion criteria: * adults undergoing cardiac surgery with cardiopulmonary bypass * left ventricular ejection fraction (lvef) \< 50% exclusion criteria: * current pregnancy * esrd or aki on dialysis * currently on ecmo or impella * emergent surgery

Keywords: acute kidney injury intra-abdominal pressure renal perfusion pressure cardiac surgery