Kornimate/medical-research-clean huggingface dataset:
diagnostic performance of general practitioners in compression ultrasound

Conditions: Deep Vein Thrombosis

Summary: the objective of this study is to evaluate the diagnostic efficiency of general practitioners for the diagnosis of proximal deep vein thrombosis of the lower limbs compared with whole-leg ultrasound with doppler performed by the vascular physician.

after being informed about the study and the potential risks, all patients who have given their written consent and who meet the eligibility criteria will benefit from a 3-point compression ultrasound performed by the general practitioner before being referred for a whole-leg ultrasound with doppler at the vascular physician.

Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years * management by a general practitioner trained in 3-point venous ultrasound * suspicion of deep vein thrombosis by the general practitioner with prescription of a whole-leg doppler ultrasound by a vascular physician. it is noted that the patient can be included from the moment the general practitioner had planned to refer the patient to the vascular physician for a suspicion of dvt, including in the absence of realization of ddimer on a low probability of dvt. it may also be included in case of positive ddimer tests. * signed written consent * patient covered by the french social security system exclusion criteria: * whole leg ultrasound performed more than 72 hours after the initial examination * history of homolateral deep vein thrombosis * patient objecting to the use of his data * refusal of written and signed consent

Keywords: dvt vein thrombosis thrombophlebitis
cytokine hemoadsorption in ecmo patients

Conditions: SIRS; Cytokine Storm; Cardiogenic Shock; Cardiac Arrest; Septic Shock; ARDS, Human

Summary: cytokine hemoadsorption is a novel therapy used to improve outcome in critically ill patients with a dysregulated cytokine response and hemodynamic instability. patients on extracorporeal membraneous oxygenation (ecmo) often develop severe systemic inflammatory response syndrome (sirs). cytokine removal using different types of hemoadsorption devices is believed to block the vicious circle of inflammation dysregulation when other basic therapeutic measures fail. to date there are very limited reports on ecmo and cytokine hemoadsorption combination therapy. the aim of this retrospective study is to evaluate feasibility and effectiveness of hemoadsorption in veno-arterial and veno-venous ecmo patients.


Eligibility criteria:
inclusion criteria: * va/vv ecmo * hemoadsorption * age ≥ 18 years exclusion criteria: * no additional exclusion criteria after being eligible for ecmo

Keywords: hemoadsorption ecmo sirs ards post-resuscitation syndrome ecpr
treatment of grammatical time marking in post-stroke aphasia

Conditions: Brain Injury, Vascular; Aphasia; Stroke

Summary: the study aims to assess an individual or self-administered computer therapy's effectiveness in grammatical time marking. the main objective is to examine whether the therapy improves grammatical time marking of inflected verbs treated on the sessions. we also explore whether the observed progress can be transferred to untrained items, more ecological contexts and if is maintained two and four weeks after the end of treatment. this therapy will be administered to six individuals with brain lesions after stroke. four individuals will take part of the individual therapy and two individuals will take part of the self-administered computer therapy. the therapy will last one month, at the rate of three weekly sessions of approximately one hour.


Eligibility criteria:
inclusion criteria: * have had an imaging-objectified stroke in adulthood that resulted in aphasia (fluent or non-fluent). the time between the stroke and participation in this study must be greater than 6 months. * be a native french speaker or have excellent mastery of french. * be between 18 and 75 years old. * present grammatical tense marking disorders objectified by language evaluation (deficit scores on the "batterie d'évaluation de la production syntaxique" (beps) verb flexion task, monetta et al., 2018; and/or on the "test d'expression morpho-syntaxique fine" (t.e.m.f.) active sentence production subtask, bernaert-paul and simonin, 2011). exclusion criteria: * present chronic symptoms of a substance use disorder as defined by diagnostic and statistical manual of mental disorders (dsm-v) criteria. * have significant uncorrected vision and/or hearing impairment. * have significant impairments in oral/written comprehension. * present apraxia of speech or a severe arthritic disorder * present hemineglect * present impaired judgment and discernment, objectified by a neuropsychological evaluation
autologous car-t cells targeting cspg4 in relapsed/refractory hnscc

Conditions: Head and Neck Cancer; Relapse; Recurrent; Refractory Cancer

Summary: the purpose of this study is to test the safety and tolerability of using a new treatment called autologous t lymphocyte chimeric antigen receptor cells against the cspg4 antigen (ic9.car-cspg4 t cells) in patients with head and neck cancer that came back after receiving standard therapy for this cancer. the ic9.car-cspg4 treatment is experimental and has not been approved by the food and drug administration. how many (dose) of the ic9.car. cspg4 t cells are safe to use in patients without causing too many side effects, and what is the maximum dose that could be tolerated will be investigated. the information collected from the study would help cancer patients in the future. there are two parts to this study. in part 1, blood will be collected to prepare the ic9.car-cspg4 t cells. disease fighting t cells will be isolated and modified to prepare the ic9.car-cspg4 t cells. in part 2, the ic9.car-cspg4 t cells are given by infusion after completion of lymphodepletion chemotherapy. the data from the dose escalation will be used to determine a recommended phase 2 dose (rp2d), which will be decided based on the maximum tolerated dose (mtd). additionally, recommended phase 2 dose will be tested. eligible subjects will receive lymphodepletion chemotherapy standard followed by infusion of ic9-car.cspg4 t cells. after treatment completion or discontinuation, subjects will be followed since involving gene transfer experiments.


Eligibility criteria:
inclusion criteria: unless otherwise noted, subjects must meet all of the following criteria to participate in all phases of the study: 1. written informed consent and hipaa authorization for release of personal health information explained to, understood by and signed by the subject; subject given a copy of the informed consent form. 2. age ≥ 18 years at the time of consent. 3. karnofsky score of \> 60% 4. histologically or cytologically confirmed stage recurrent/metastatic squamous cell carcinoma of the head and neck as defined by american joint committee on cancer (ajcc). this includes squamous cancer of: oral cavity, oropharynx, hypopharynx and larynx. exclusion criteria: 1. subject with a history or current severe progressive heart disease (congestive heart failure, coronary artery disease, uncontrolled arterial hypertension, uncontrolled arrhythmia, or myocardial infarction in the past 6 months. 2. subject with a history of stroke or transient ischemic attack (tia) within 12 months before procurement. 3. subject with a history of severe immediate hypersensitivity reaction to cyclophosphamide or fludarabine.

Keywords: cellular therapy
a study for older adults with acute lymphoblastic leukaemia

Conditions: Acute Lymphoblastic Leukaemia

Summary: the ncri adult all sub-group propose to collaborate with the dutch/belgian group hovon to carry out a prospective, non randomised multi-arm study (including a choice of regimen intensity) to investigate the safety, tolerability and feasibility of a standardised therapy protocol for patients ≥ 60 years old with de novo all. the overall aim is define a basic standard of care upon which trials of novel therapies will be based in future. the design of the study will enable collection of a comprehensive dataset regarding the clinical outcome, complete response rate (cr) and minimal residual disease (mrd) response rates in a previously completely uncharacterised population, thus providing the essential platform for designing future randomised advanced phase studies in which new therapeutic approaches and novel therapies can be prospectively investigated.

the study will 1. establish baseline expectations for event free survival (efs), overall survival (os), mrd responses and quality of life measures for older patients of all ages and pre-morbid states; 2. disclose how best to use knowledge of pre-morbid characteristics to apply the appropriate intensity of therapy in order to balance the best disease related outcomes against quality of life; 3. establish national standards of care for this patient group; 4. provide the essential platform for careful design of future randomised advanced phase studies of new therapeutic approaches and agents.

Eligibility criteria:
inclusion criteria: * age ≥ 60 with acute lymphoblastic leukaemia (all) or ≥ 55 with acute lymphoblastic leukaemia (all) unsuitable for the ukall14 or hovon 100 trial * newly diagnosed, previously untreated all (a steroid pre-phase of 5-7 days may be given before trial registration)) * willing and able to give consent exclusion criteria: * known hiv infection * blast transformation of cml * mature b-cell leukaemia i.e. burkitts disease t(8,14)(q24 ;q32) and variant c-myc translocations e.g. t(2;8)(p12 ;q24), t(8;22)(q24;q11) * women who are pregnant or lactating
ultrasound (us)-doppler for the diagnosis of asymptomatic deep vein thrombosis (dvt) in gynecologic cancer patients

Conditions: Deep Vein Thrombosis

Summary: the aim of this study is to determine the prevalence of asymptomatic lower extremity dvt detected by doppler ultrasound in a selected group of patients suffering from gynecological malignancies.

the association between malignancy and venous thromboembolism (vte) is well known. it has been shown that there is a high prevalence of vte in gynecological malignancies. early detection of vte can identify patients who may benefit from anticoagulant therapy and prevent morbidity and mortality. no clear guidelines are available for anticoagulant prophylaxis in a selected group of ambulatory gynecological cancer patients. it has been shown, in other selected groups of patients that ultrasound doppler can be used in order to diagnose asymptomatic dvt (deep vein thrombosis).

Eligibility criteria:
inclusion criteria: * gynecological cancer patients * ambulatory performance status of 0-2 * prior to, or during, chemotherapy and/or radiation exclusion criteria: * before or near surgery

Keywords: deep vein thrombosis gynecological cancer
virtual reality's effect on decreasing pain and subsequent opioid use in pediatric patients in the post-operative period following scoliosis repair

Conditions: Scoliosis; Juvenile; Scoliosis; Adolescence; Scoliosis

Summary: the goal of this study is to determine whether introducing vr in the immediate post-operative period following scoliosis repair can reduce perceived pain and stress in pediatric patients and in turn ultimately decrease opioid use. based on previous studies that have been performed in other fields of pediatrics showing a decrease in pain and stress with vr use, the investigators hypothesize that vr will significantly decrease patient's reported level of pain and stress immediately following the vr session, and that patients will require less opioids during their inpatient stay as a result.

this project evaluates whether providing pediatric post-operative scoliosis repair patients with a virtual reality (vr) session at specific time point following surgery can decrease pain and stress experienced and if this leads to a decrease in the use of pain medications required during the immediate recovery period. virtual reality technology was ordered to use as a distraction tool as part of routine pediatric care for hospitalized patients. the study involves measuring pain and stress using validated scales as well as calculating opioid use in this specific pediatric post-operative scoliosis repair population. all post-operative scoliosis repair patients admitted to the inpatient pediatric floor above 7 years of age will be eligible for participation in this study. the goal is to collect data on at least 50 patients over the course of 12-18 months. parental consent and child assent will be obtained on day 2 post-op surgery using a standardized consent and assent form, respectively. data will be collected from the numerical pain rating scale and the state trait anxiety inventory, which will be administered pre- and post-vr sessions, with the goal of comparing scores to evaluate for any decrease in pain and stress levels. data on inpatient opioid use post-operatively will be used to compare with previous post-operative scoliosis patients to determine whether there a significant decrease in opioid use in the subjects exposed to vr. during the data collection process, results will be documented in an organized but deidentified manner.

Eligibility criteria:
inclusion criteria: * all pediatric patients post scoliosis repair * age 7-21 exclusion criteria: * age less than 7 years; * history of seizures, epilepsy, * history of motion sickness/balance problems, * susceptibility to migraines * currently pregnant
italian pulmonary embolism registry - iper

Conditions: Acute Pulmonary Embolism

Summary: razionale pulmonary embolism is a complex disease, with a highly variable clincal presentation. diagnosis starts with clinical probability assessment mainly based on medical history and rapidly available clinical data. pulmonary embolism can be managed by emergency department, cardiology, pneumology geriatrics or internal medicine physicians. thus, initial clinical management can varies based on the attitude of the attending physician. diagnosis is a crucial point as it can influence short term mortality. objective the registry has 3 main objectives: 1. educational objective, 2. improvement in the knowledge of epidemiology, management and outcome of acute pulmonary embolism in italy 3. scientific objective


Eligibility criteria:
inclusion criteria: * consecutive patients with acute pulmonary embolism exclusion criteria: * age \<18 years
effects of ivabradine in patients with stable coronary artery disease without clinical heart failure

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to evaluate the effect of ivabradine on cardiovascular events in patients with coronary artery disease.


Eligibility criteria:
inclusion criteria: * evidence of coronary artery disease * sinus rhythm and resting heart rate equal or higher than 70 bpm exclusion criteria: * unstable cardiovascular condition * known hypersensitivity to ivabradine or current treatment with marketed ivabradine
mechanism of egr2 in allergic rhinitis

Conditions: Rhinitis, Allergic

Summary: egr2 may be a target for the treatment of nasal polyps.

there is much debate about the etiology of nasal polyps, so the pathogenesis of nasal polyps still needs to be clarified. surgery for noninflammatory nasal polyps may be better control, but surgery is not effective for recurrent sinusitis and nasal polyps. therefore, more research is needed to determine the best targeted therapy for nasal polyps. we found that egr2 expression was upregulated in crswnp patients with allergic rhinitis.in addition, the expression of egr2 in crswnp mucosa was significantly higher than that in the control group, and the expression of egr2 in crswnp with allergic rhinitis was higher than that in crswnp without allergic rhinitis. egr2 may be involved in the pathogenesis of nasal polyps, and may also be related to the severity and recurrence of nasal polyps. egr2 may be a target for the treatment of nasal polyps.

Eligibility criteria:
inclusion criteria: all patients were stopped by systemic or topical corticosteroid treatment at least one month before the study. exclusion criteria: patients had nps accompanied by choanal polyps, fungal nasal sinusitis, cystic fibrosis, acute upper airway upper infection or other systemic diseases.

Keywords: nasal polyps chronic rhinosinusitis atopic nps non-atopic nps egr2
rheumatoid arthritis and treatment of periodontitis: a randomized clinical trial.

Conditions: Periodontitis; Arthritis, Rheumatoid

Summary: periodontitis is an infectious disease defined by bacteria-mediated inflammation of the supporting tissues of the teeth that if left untreated may ultimately lead to the destruction of the attachment apparatus, culminating in tooth loss. rheumatoid arthritis is a chronic destructive inflammatory disease characterized by autoantibodies and the accumulation and persistence of an inflammatory infiltrate in the synovial membrane that leads to synovitis and the destruction of the joint architecture. the objective of this study was to evaluate the possible beneficial additional value of non-surgical periodontal therapy on systemic markers of inflammation and clinical and serological parameters of rheumatoid arthritis.


Eligibility criteria:
inclusion criteria: * subjects affected by rheumatoid arthritis with a stable therapeutic regimen for at least 3 months preceding the study participation * subjects with at least 15 teeth * subjects affected by severe generalized periodontitis that had undergone no periodontal treatment in the 6 months preceding the study participation exclusion criteria: * age younger than 18 years * pregnancy or breastfeeding * edentulism * diagnosis of other autoimmune pathologies, liver disease, diabetes, early/juvenile arthritis or syndromes associated with ra

Keywords: periodontitis rheumatoid arthritis treatment of periodontitis
"machine learning analysis of lingual colorimetry and madrs anxiety-depression score in acupuncture patients"

Conditions: Anxiety Disorders

Summary: this observational study aims to assess the potential relationship between tongue colorimetry (using standardized photographic techniques) and anxiety-depression scores measured by the montgomery-åsberg depression rating scale (madrs) in acupuncture patients. data will be analyzed using machine learning methods to determine whether tongue color features correlate with madrs scores, possibly contributing to a novel, non-invasive diagnostic tool for anxiety and depression assessment in clinical practice. participation involves only tongue photography and completion of questionnaires, without any invasive procedures or treatment modifications.

this prospective observational study investigates the correlation between lingual colorimetry, captured using readily available and standardized modern photographic tools (iphone cameras), and anxiety-depression scores evaluated by the montgomery-åsberg depression rating scale (madrs) among patients attending routine acupuncture consultations. participants will undergo a simple and non-invasive photographic recording of their tongue using an iphone, ensuring consistent lighting and standardized positioning to minimize variability. simultaneously, participants will complete the madrs questionnaire, a widely validated instrument for assessing anxiety and depression severity. no invasive procedures or therapeutic interventions beyond their usual acupuncture care will be performed. the acquired photographic data will be analyzed using machine learning algorithms to identify potential predictive relationships between distinct colorimetric characteristics of the tongue and the madrs scores. the objective is to determine whether lingual imaging could serve as a reliable, non-invasive biomarker or complementary diagnostic tool for assessing psychological status in clinical practice. this approach leverages everyday technology (smartphones), promoting ease of replication and broader accessibility in clinical environments. ultimately, findings from this study could facilitate early detection and monitoring of anxiety-depressive disorders, thus enhancing individualized patient care in complementary and integrative medicine.

Eligibility criteria:
inclusion criteria: * patients aged 18 years or older * native french speakers * no medical conditions or medications affecting tongue coloration * consulting for acupuncture with symptoms involving an anxious component exclusion criteria: * presence of psychosis or substance abuse * eating or taking medication within one hour before the examination * refusal to complete the montgomery-åsberg depression rating scale (madrs) questionnaire * refusal to have their tongue photographed

Keywords: tongue colorimetry madrs depression anxiety machine learning acupuncture artificial intelligence image analysis
acupuncture as a complementary therapy for in vitro fertilization patients: a randomized controlled trial

Conditions: Acupuncture; Quality of Life; Infertility; Stress; Anxiety

Summary: this is an open-label randomized controlled trial of the use of acupuncture in infertile patients receiving in vitro fertilization (ivf). patients will be randomized into two groups: treatment group will receive acupuncture as a complementary approach to ivf and control group will receive the ivf treatment. groups will be compared with the world health organization quality of life (whoqol-bref), short-form 36 (sf-36), state trait anxiety inventory (stai) and scope-stress questionnaires.

this is an open-label randomized controlled trial of the use of acupuncture in infertile patients receiving in vitro fertilization (ivf). patients will be randomized into two groups: treatment group will receive acupuncture as a complementary approach to ivf and control group will receive the ivf treatment. groups will be compared with the world health organization quality of life (whoqol-bref), short-form 36 (sf-36), state trait anxiety inventory (stai) and scope-stress questionnaires. in addition, data from medical records of infertile patients submitted to in vitro fertilization for treatment of infertility will be compared in the two different treatment groups (with and without acupuncture), such as the required dose of drugs for the treatment, number of ovarian follicles, number of oocytes captured, quality of oocytes, number of embryos, quality of embryos, pregnancy and abortion rates.

Eligibility criteria:
inclusion criteria: * female patient * age over 18 years * diagnosis of infertility with indication of ivf * agreement accept to participate in the study * signature of the consent form exclusion criteria: * history of previous contact with the acupuncture technique * severe neurological or psychiatric disorders that make it impossible to participate in the study

Keywords: acupuncture infertility in vitro fertilization quality of life stress anxiety