Kornimate/medical-research-clean huggingface dataset:
the efficacy and safety study of electro-acupuncture for severe chronic functional constipation

Conditions: Constipation

Summary: the main purpose of this study is to evaluate efficacy of electro-acupuncture for severe functional constipation compared with sham acupuncture, used as placebo; the secondary purpose is to evaluate the safety and post-treatment effect of electro-acupuncture.

chronic functional constipation is a common disease. to date there has not specific therapy on chronic functional constipation. systematic reviews indicate that acupuncture is probably effective for the disease, but the evidence is limited. recently, we have finished a multi-center clinical trial of individualized deep electro-acupuncture (ea) for chronic functional constipation (n=460, registration id: nct00508482) which preliminarily showed ea was effective. this multi-center large-sample randomized controlled clinical trial of acupuncture for severe functional constipation is designed to confirm the efficacy and safety of ea. this project is conducted by chinese experts, supported by the chinese government. the research result is expected to provide high quality evidence of ea for chronic functional constipation.

Eligibility criteria:
inclusion criteria: * meeting the diagnosis of rome iii criteria for chronic functional constipation; * severe chronic constipation: two or fewer spontaneous complete bowel movements per week for more than 3 months; * 18-75 years old; * no use of medicine for constipation during the two weeks before enrollment (except rescue medication); * no acupuncture treatment for constipation in recent 3 months; * never joined any other trial in process in 3 months; * volunteered to join this research and signed the informed consent. exclusion criteria: * irritable bowel syndrome (ibs) and constipation caused by endocrine, metabolic, nervous or postoperative diseases or drugs; * constipation accompanied by serious cardiovascular, hepatic, renal, or psychiatric disease, cognitive dysfunction or aphasia, or severe dystrophy affecting the cooperation for examination or treatment; * pregnant women or women in lactation period * constipation accompanied by abdominal aneurysm, hepatosplenomegaly, etcetera; * bleeding disorders, or regular anticoagulant drug users, such as warfarin and heparin, etcetera; * cardiac pacemaker carrier.

Keywords: chronic functional constipation electro-acupuncture multi-center randomized controlled trial efficacy safety
predictors of upper airway function and sleep-disordered breathing in the critically ill

Conditions: Critically Ill; Obstructive Sleep Apnea

Summary: this is part 2 of the #nct01618240 under the same irb protocol #2010p001919. the primary objective of this study is to examine factors that are related to sleep-disordered breathing and upper airway patency in critically ill patients who have been recently mechanically ventilated. our primary hypothesize is that sedatives and neuromuscular blocking agents given in the icu prior to extubation and during the first night following extubation are associated with sleep-disordered breathing. the secondary hypotheses are that duration of mechanical ventilation, bmi, and muscle strength are associated with sleep-disordered breathing during the night after extubation. the secondary objective is to evaluate if sleep-disordered breathing in the icu can be predicted by standard pulmonary function testing in the icu.


Eligibility criteria:
inclusion criteria: 1. patients admitted to the sicu 2. age over 18 years. 3. ventilated patients with an endotracheal tube for at least 24 hours. exclusion criteria: 1. decreased level of consciousness as defined by a richmond agitation sedation scale (rass) of 0. 2. non-cooperative patient, cam score positive for risk of delirium. 3. for women: pregnancy.

Keywords: critically ill, osa, mechanical ventilation
the effect of the mediterranean diet on fatty acids in biological fluids of women undergoing infertility treatment

Conditions: Women Diagnosed With Infertility

Summary: the aim of this study was to examine the effect of the mediterranean diet, which is accepted as one of the adequate and balanced nutrition models today, as well as serum and follicular fluid fatty acid profile and implantation success in women with an age range of 19-40 (years) before infertility treatment. the study was conducted as a prospective and case-control study with a total of 32 volunteer women, 16 in the intervention group and 16 in the control group, who applied to gazi university hospital between february 2021 and february 2022.


Eligibility criteria:
inclusion criteria: women diagnosed with infertility women between the ages of 19-40 women with bmi \<30 kg/m² women undergoing assisted reproductive treatment in which updated oocytes and semen be used women undergoing assisted reproductive treatment (art), iui or one of the first 3 ivf/icsi treatments (number of art treatments ≤ 3) exclusion criteria: women diagnosed with chronic diseases other than infertility women who smoke and drink alcohol women on art who will use frozen eggs or semen women with bmi \>30 kg/m2 at the first measurement women experiencing communication breakdown/timeout, becoming pregnant, difficulty adhering to a diet program or art while the intervention is ongoing

Keywords: fatty acids, folicular fluid, implantation, infertility, mediterranean diet, ratio of ω6/ω3fatty acid
investigation of inspiratory muscle strength and cardiorespiratory fitness in sarcopenic individuals

Conditions: Geriatric Individuals

Summary: the aim of our study is to examine the effects of sarcopenia and dynapenia on inspiratory muscle strength and cardiorespiratory fitness in geriatric individuals.

within the scope of the study, anterior thigh thicknesses of geriatric individuals will be evaluated by ultrasonography and individuals will be divided into 3 groups as dynapenic, sarcopenic and normal according to the isarcoprm algorithm, using the star method and hand-grip. the powerbreathe k5 device will be used to evaluate the inspiratory muscle strength of geriatric individuals in both groups, and the 2-minute step test will be used to evaluate cardiorespiratory fitness. the study will be carried out with 100 geriatric individuals. as a result of the study, first the inspiratory muscle strength and cardiorespiratory fitness of sarcopenic, dynapenic and non-sarcopenic groups will be compared. afterwards, the relationship between anterior thigh thickness and inspiratory muscle strength of all geriatric individuals participating in the study will be examined.

Eligibility criteria:
inclusion criteria: * getting a score between 24 and 30 on the mini mental state assessment * ability to stand without assistance for at least 90 seconds exclusion criteria: * inability to communicate verbally * using a walking aid * older adults with severe visual impairment, neurological disorders, and/or congestive heart failure * older adults for whom exercise is not recommended
effects of efficient lifestyle counseling method on the risks of cardiovascular disease in health care center patients

Conditions: Obesity

Summary: the aim of the trial is to study the effect of a lifestyle change program in patients with obesity and risk of cardiovascular diseases. the main focus is to motivate and support lifestyle changes. two different group counseling methods (intensive and standard) with or without internet support will be compared. thus, the patients will be randomized into four arms. patients will be recruited from local general practice teams. the intensive lifestyle counseling consists of 12 group counseling sessions and 2 personal counseling sessions. the standard counseling consists of 4 group sessions. the internet-based counseling contains aspects of cognitive behavior therapy and persuasive design system and consists of weekly reminders, tasks, self-monitoring, and reflection. the main outcome is the decrease in body weight. secondary outcomes are changes in eating behavior, eating habits, components of metabolic syndrome (waist circumference, plasma lipid and glucose values), and calculated scores of cardiometabolic condition, cardiovascular risk and adiposity.


Eligibility criteria:
inclusion criteria: * body mass index 30 to 40 kg/m2 * + 2 risk factors of cardiovascular diseases: * elevated blood pressure or hypertension * high ldl or hypocholesterolemic drug * low hdl or hypocholesterolemic drug * elevated triglyceride value or hypolipidemic drug * elevated glucose value or diabetes medication * smoking * access to email and internet exclusion criteria: * untreated hypothyroidism * oral corticosteroid treatment * pregnancy and lactation * angina pectoris * cardiac insufficiency * coronary heart disease * inability to speak finnish * anticipated lack of compliance
nse/alb as a prognostic biomarker for lung cancer

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: the incidence and mortality rate of lung cancer is the highest in the world. current studies have found that tumor markers, inflammatory or nutritional indicators have a good predictive value for the prognosis of patients with non-small cell lung cancer (nsclc). neuron specific enolase (nse) and serum albumin (alb) are important indicators for monitoring tumor progression and nutritional status in lung cancer patients, respectively. previous studies suggested that the higher the nse, the worse prognosis of nsclc patients, while the lower the alb, the worse the prognosis of patients with malignant tumors. through a retrospective study, the investigators found that nar (nse alb ratio) was higher and prognosis was poorer in patients undergoing nsclc surgery. this is better than the previous assessment indicators plr (platelet to lymphocyte ratio), nlr (neutrophil to lymphocyte ratio), agr (albumin to globulin ratio), nar can better assess prognosis. therefore, on the basis of the previous retrospective analysis, the optimal nar cut-off value was calculated according to roc curve, and the value was grouped into multi-center prospective cohort study, and the relationship between nar and other clinical indicators was studied by chi-square test. univariate and multivariate analysis of cox proportional hazard regression model was used to determine the prognostic factors. finally, nsclc patients were stratified according to tumor stage and pathological classification, and the differences of survival time between high nar group and low nar group were compared again under different stages and types, and the different stages of nar in nsclc patients were further analyzed. the clinical significance of typing. by exploring and validating the relationship between nar and the prognosis of nsclc patients, the investigators try to establish a new prognostic index. obviously, it has important value for clinical application.


Eligibility criteria:
inclusion criteria: * (1) pathological diagnosis of non-small cell lung cancer * (2) 18-70 years of age and no gender restriction. * (3) patients who were admitted for the first time and underwent routine blood tests, three lung cancer and liver function tests. exclusion criteria: * (1) pregnant or lactating women * (2) patients with other malignancies at the same time * (3) patients with acute and chronic inflammation, autoimmune diseases, and patients with obvious liver and renal insufficiency. * (4) patients with incomplete clinical and pathological data.

Keywords: neuron-specific enolase albumin prognostic biomarker
comparative study between homa1-ir and homa2-ir in prediction of ovulation outcome in women with pcos

Conditions: Polycystic Ovarian Syndrome (PCOS)

Summary: 122 women diagnosed with pcos seeking fertility in the fertility clinic at kasr alainy hospital will be subjected to homeostatic model assessment for insulin resistance 1 was calculated for all participants through the equation \[glucose (mmol/l) × insulin (µu/l)\]/22.5 while homeostatic model assessment for insulin resistance 2 was calculated by the homa2 calculator. all women will be subjected to induction of ovulation using the aromatase inhibitor letrozole 2.5 mg tab twice daily from the 3rd day of the cycle for 5 days . ultrasound follow up of follicular growth will be performed till dominant follicular size reaches 18-22 mm. fsh preparations will be introduced as needed.


Eligibility criteria:
inclusion criteria: * age 18-35 years * duration of infertility 1-4 years * pcos exclusion criteria: women with other causes of infertility (tubal factor assessed by laparoscopy or hysterosalpingogram, uterine cavity abnormality assessed by ultrasound or hysteroscopy or male factor assessed by seme analysis), * endometriosis, * ovarian cysts, * endocrinological abnormalities (diabetes mellitus, hypothalamic, pituitary or thyroid disorders, or hyperprolactinemia), * women with history of poor ovarian response or ovarian hyperstimulation * women with chronic diseases, chromosomal, autoimmune or coagulation defects, abnormal leucocytic count or other inflammatory markers * women with contraindications to pregnancy.
uterine leiomyoma treatment with radiofrequency ablation (ultra) registry

Conditions: Uterine Fibroids

Summary: the ultra registry is a nationwide observational arm of the ultra trial. data from the ultra registry will be used to evaluate the long-term safety and efficacy of laparoscopic rf ablation (acessa). the ultra registry will recruit women age 21 or older who plan to undergo or have undergone laparoscopic rf ablation (acessa) or myomectomy within the united states. participants will be recruited through study materials distributed at clinical offices across the country where gynecologists are performing laparoscopic rf ablation (acessa). study participants will consent to participate in a 3 year prospective study conducted by ucsf but the fibroid procedure will be performed by the study participants' own gynecologist. we will evaluate changes in fibroid-related symptoms from pre-treatment values to 6, 12, 18, 24, 30, and 36 months after rfa (acessa). we will determine long-term efficacy of rfa (acessa) by evaluating the rate of re-treatment for symptomatic fibroids after the rfa (acessa) procedure versus myomectomy. participants will be asked for permission to review their medical records to assess surgical and pregnancy outcomes. uc san francisco will have oversight of all scientific and administrative aspects of the study. all study data will be stored securely in a hipaa compliant, secure database monitored by the uc san francisco coordinating center.


Eligibility criteria:
inclusion criteria: * planning to undergo or have undergone\* rf ablation (acessa) or myomectomy (laparoscopic or abdominal) for treatment of uterine fibroids. * able to give informed consent * speak english or spanish * women enrolled at contracted clinical sites must enroll prior to their rf ablation treatment exclusion criteria: * \<21 years of age * plan to undergo hysteroscopic myomectomy

Keywords: fibroids radiofrequency ablation myomectomy
understanding metabolism and inflammation risks for diabetes in adolescents

Conditions: Type 2 Diabetes; Insulin Resistance; Obesity; Metabolic Disease; PreDiabetes

Summary: this research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (mimos) in adolescents. the hypothesis of this study is that adolescents at risk for metabolic disease have enhanced mimo related activities leading to insulin resistance.


Eligibility criteria:
inclusion criteria: * between 14 and 18 years of age * tanner stage 4 or 5 (mature adult stage of puberty) * normal weight (bmi ≥ 5th percentile \& \ 86th percentile) \& \ 5.7%) * for type 2 diabetes cohort, diagnosis of type 2 diabetes exclusion criteria: * currently pregnant * use medications known to affect glucose metabolism (immunosuppressive medications, cancer medications, or high dose steroids), unless prescribed for type 2 diabetes management * prior diagnosis of autoimmune disease, cancer, or a cognitive or perceptual disability that would inhibit following directions of study staff * allergies or intolerance to milk, soy, or palm oil
a study of shr-a1921 for injection in subjects with advanced solid tumours

Conditions: Advanced Solid Tumours

Summary: to assess the safety and tolerability of shr-a1921 in patients with advanced solid tumours, to determine the dose-limiting toxicity (dlt), maximum tolerated dose (mtd), and/or recommended phase ii dose (rp2d) of shr-a1921


Eligibility criteria:
inclusion criteria: 1. voluntary participation and written informed consent； 2. aged 18-75 years (inclusive), males and females; 3. consents to provide tumor tissue samples; 4. subjects must have histologically or clinically confirmed advanced and/or metastatic malignancies for which failure of standard treatment or lack of effective standard treatment; 5. at least one measurable lesion according to recist v1.1; 6. ecog score of 0-1; 7. expected survival ≥ 12 weeks; 8. adequate bone marrow reserve and organ function ； 9. for female patients of childbearing potential or male patients with partners of childbearing potential who are not sterilized by surgical operations, they are required to use a medically approved contraceptive measure during the study treatment period and within 3 months after the end of the study treatment; for female patients of childbearing potential who are not sterilized by surgical operations, they must have a negative serum hcg test result within 72 h prior to study enrollment; and they must not be in the lactation period; exclusion criteria: 1. known and untreated central nervous system (cns) or leptomeningeal metastases; 2. macrovascular invasion based on imaging; 3. cancerous ascites, pleural effusion or pericardial effusion with clinical symptoms; 4. has a history of a second malignancy; 5. history of immunodeficiency disease or organ transplant; 6. uncontrolled cardiac diseases or symptoms; 7. has a history of non-infectious ild/pneumonitis that required steroids, or has current ild/pneumonitis; 8. has a history of active chronic enteritis 6 weeks prior to the initiation of the study treatment or intestinal obstruction, gastrointestinal perforation 3 months prior to the initiation of the study treatment; 9. has a history of grade≥2 bleeding 4 weeks prior to the initiation of the study treatment or is current receiving anticoagulation therapy; 10. subjects with active hepatitis b or active hepatitis c; 11. subjects who have received systemic anti-tumor treatments 4 weeks prior to the initiation of the study treatment. 12. has unresolved toxicities from previous anticancer therapy. 13. has a history of severe hypersensitivity reactions to either the drug substances or inactive ingredients of shr-a1921; 14. subjects with other potential factors that may affect the study results or result in the premature discontinuation as determined by the investigator, such as alcoholism, drug abuse, other serious diseases (including mental illness) requiring concomitant treatment, serious laboratory abnormalities, or family or social factors that could affect the safety of the patients.
retrieval of displaced root in the maxillary sinus via lateral bony window using the piezoelectric device

Conditions: Oroantral Fistula; Displaced Tooth

Summary: ten patients with displaced root in maxillary sinus will be included in this study. the root will be recieved via lateral bony window in maxillary sinus wall using peizoelectric device then the bony window will be repositioned in its place.the patients will be received, clinically and radiologically examined, managed and followed up at the oral and maxillofacial surgery department, faculty of dentistry, tanta university

purpose: this study is designed to allow removal of displaced root from maxillary sinus with minimal surgical injury and simultaneous preservation of the integrity of the lateral wall of maxillary sinus by repositioning of osteotomized lateral bony window. materials \& methods: ten patients with displaced root in maxillary sinus will be included in this study. surgical procedure: a full thickness flap will be elevated to expose the lateral wall of the sinus and a rectangular bony window will be done, then the sinus lining will be incised, the displaced root will be delivered, the bony window will be repositioned, and the flap will be sutured. preoperative evaluation: the patients will be evaluated clinically for presence of inflammation, infection or oroantral communication and radiographically using computed tomography (ct) scan to identify the position of the displaced root. postoperative evaluation: the patients will be evaluated clinically each week for one month regarding to healing, presence of infection, inflammation. radiographically, immediate panoramic view to evaluate the position of bony window and four months later to evaluate bone healing ct scan.

Eligibility criteria:
inclusion criteria: root displaced in maxillary sinus absence of infection exclusion criteria: * • patients taking medications that affect bone healing * patients underwent head and neck radiotherapy

Keywords: displaced root maxillary sinus lateral bony window piezoelectric device
symptoms and endoscopic results in consideration of pretreatment

Conditions: Gastrointestinal Diseases

Summary: under daily routine conditions and without any intervention by the sponsor regarding the selection of subjects, diagnostic procedures, therapeutic decisions (medicinal and non- medicinal therapy, dose, duration, etc.), routine assessments, the participating physicians (i.e. gastroenterologists) are asked to document relevant data in patients with gastrointestinal disorders.


Eligibility criteria:
inclusion criteria: * patients with gastrointestinal disorders who need an endoscopy. exclusion criteria: * limitiations; possible risks; warnings; contraindications mentioned in the spc.

Keywords: gastrointestinal disorder endoscopy patient with gastrointestinal disorders for whom an endoscopy is performed and who is treated with esomeprazole afterwards.
dietary intake and vitamin d level in adult women

Conditions: Deficiency of Vitamin D3

Summary: vitamin d deficiency is most diagnosed among women living in the kingdom of saudi arabia. many factors have been attributed to the incidence of vitamin d deficiency. saudi women are thought to be at greater risk for vitamin d deficiency because of their darker skin type and the likelihood of reduced ultraviolet exposure . the present study entitled, "dietary intake and vitamin d level in adult women," was formulated as there is paucity of data on the etiologic importance of dietary intake in vitamin d level on blood on women. the major objective of the proposed study is to assess the effect of dietary intake of nutrients and level of vitamin d in women .

for this study, the investigators enrolled 168 women 35-55 years old to evaluate vitamin d status and to determined whether status was correlated with vitamin d deficiency. all women completed a self-administered questionnaire about personal socio-demographic characteristics; they all had anthropometric measurements of body mass index and waist circumference. a 24-hour dietary recall was administered to all women. the proximate analysis of 25 types of food was conducted according to the american association of organic chemists (aoac) methods. the following parameters were measured: serum calcium. vitamin d, levels of parathyroid hormone.

Eligibility criteria:
inclusion criteria: * women 35- 55 years old, * women who spoke arabic language fluently, and * women who were willing to fill a 24-hour questionnaire and provide a serum sample for measurements. exclusion criteria: * women \ 55 years old.

Keywords: vitamin d calcium phytic acid body weight