Kornimate/medical-research-clean huggingface dataset:
sport without injury programme floorball

Conditions: Athletic Injuries

Summary: this study evaluates the preventive effect of a neuromuscular training program on injuries in youth floorball players. half of participants will receive the training program, and half act as control and perform their usual training practices.

the study is a cluster-randomized controlled trial including male and female youth (12-17 years) floorball players. club is used as cluster unit. coaches in the intervention group receive education of the preventive neuromuscular training program knee control (knäkontroll) before the start of the season. knee control consists of 6 different exercises, with 4 different variations and 1 pair-exercise, and takes about 10 minutes to complete. in addition, coaches are instructed to perform a 5-minute running warm-up before the knee control exercises. teams are to carry out the intervention at all training sessions, and the 5-minute warm-up also before all matches. coaches in the control group carry on their normal training and warm-up routines with their clubs. teams are followed for one full season: october 2017 - march 2018. data registered for the study include exposure to floorball training and matches, and injuries that occur as a result of participation in floorball.

Eligibility criteria:
inclusion criteria: * teams with players 12-17 years of age (born 2000-2005) * teams who have not used a structured training program aiming to prevent injuries (the knee control or similar program) on a regular basis the last year * teams who have training at least twice per week exclusion criteria: -
individualized dietary intervention in breastfeeding women: body weight and vitamin a stores

Conditions: Overweight and Obesity; Vitamin A Deficiency; Dietary Modification; Breastfeeding

Summary: breast milk is the best food during the first 6mo of life because it offers multiple benefits for the mother-infant pair. an inadequate maternal diet during pregnancy can lead to excess weight gain, leading to negative health consequences for the dyad. in mexico, an excess of body weight coexists with micronutrient deficiencies (double burden of malnutrition). low vitamin a concentration has been observed in northwest mexico, which can affect the human milk composition and increase the risk of vad in breastfed babies. an individualized dietary intervention in the lactating woman will reduce body weight and improve vitamin a status. the objective is to assess the effect of an individualized dietary intervention during 3 months postpartum on body composition and vitamin a status of lactating women.

this protocol was approved by the bioethics committee of the department of medicine and health sciences of universidad de sonora. a randomized controlled trial will be carried out and participant women will be assigned by simple randomization 1:1 to either the intervention or control group, upon signing an informed consent. at baseline (2wk postpartum), anthropometric (weight, height, mid upper-arm circumference and triceps skinfold thickness) and body composition (dxa) measurements as well as the assessment of vitamin a status (serum and breastmilk retinol and the modified relative dose response) will be performed. the control group will receive only recommendations for a healthy diet in accordance with international standards and will be followed up every month to promote adherence and to assess their nutritional status. on the other hand, the intervention group will receive an individualized macronutrient meal equivalent menu, with nutritional consultations every two weeks. the dietary plan will include 1-1.5 g/kg body weight protein, 30% total fat (preferably mono and polyunsaturated fatty acids), and vitamin a sources (1300 rae). after 3 months of intervention are completed, baseline measurements will be repeated. statistical analysis will include descriptive stats and comparisons between groups (t-tests), significance will be defined as p \< 0.05.

Eligibility criteria:
inclusion criteria: * bmi ≥ 25 * predominant breastfeeding * signed informed consent exclusion criteria: * multiparity * alcohol, drugs, tobacco intake * use of dietary supplements * active infection (c reactive protein \> 6mg/l) * external nutritional counseling * pregnancy during the study period * liver disease

Keywords: food-based intervention postpartum weight management hepatic retinol
azd5423 multiple ascending dose study

Conditions: Healthy

Summary: the aim of the study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of azd5423 following multiple ascending dose administrations in healthy male and female subjects


Eligibility criteria:
inclusion criteria: * provision of signed and dated, written informed consent prior to any study specific procedures * have a body mass index (bmi) between 18 and 30 kg/m2 and weigh at least 50 kg and no more than 100 kg exclusion criteria: * any clinically significant disease or disorder * any clinically significant abnormalities at screening examination * use of any prescribed or non-prescribed medication

Keywords: safety tolerability healthy inhalation healthy volunteers
electrocautery versus scalpel for skin incisions

Conditions: Wound Complication; Surgical Wound Infection; Post-operative Pain

Summary: the aim of this research project is to compare electrocautery to scalpel for laparotomy skin incisions, with the following objectives: 1. to investigate whether electrocautery produces a cosmetically inferior surgical scar. 2. to compare the rates of wound infection with each technique. 3. to determine if electrocautery results in less postoperative pain. our null hypothesis is that electrocautery is equivalent to scalpel for creating skin incisions; with respect to wound cosmesis, wound infection rate, and post-operative pain.


Eligibility criteria:
inclusion criteria: * patients over 19 years old * bowel resection surgery * incision is 3cm or larger exclusion criteria: * diagnosed with a connective tissue disease (e.g. systemic lupus, scleroderma, polymyositis, dermatomyositis, marfan syndrome, ehler's danlos, etc.) * the site of planned surgery has a previous surgical scar.

Keywords: electrocautery
skin closure with tissue adhesives vs. subcuticular suture after robotic urogynecologic procedures

Conditions: Surgical Wound; Tissue Adhesion

Summary: to compare skin closure via subcuticular suture versus tissue adhesive (dermabond) in urogynecological robotic surgeries. the primary outcome is incision cosmesis at the 12 week follow up visit. secondary outcome is the operative time between the two methods of closure.

the purpose of this study is compare skin closure via suture versus tissue adhesive (dermabond) in urogynecological robotic surgeries. the primary outcome is incision cosmesis. therefore, if the tissue adhesive is cosmetically comparable to that of sutures, that will be reason to use tissue adhesives over traditional sutures. in these surgeries, there are five to six port sites (compared to fewer for usual laparoscopic procedures) and the procedures are lengthy procedures (average duration about 300 minutes as per recent augs/acog committee opinion), so if the investigators can show significant time reduction for closure, that should reduce operative time and costs. to the investigators' knowledge, this will be the first study of its kind to make this comparison for urogynecologic robotic procedures.

Eligibility criteria:
inclusion criteria: * women, ages 18 years and older, undergoing any urogynecologic robotic procedure at st. john hospital and medical center from march 19, 2018 - november 30, 2018. exclusion criteria: * we will exclude women with active skin infections as they may contribute to poor wound healing and infections. we will also exclude procedures that are converted to laparotomy.
hypothermic versus normothermic cardiac bypass in patients undergoing cabg surgery, effect on coagulation; randomized controlled trial

Conditions: CABG Surgery, Cold Blood Cardioplegia, Coagulation Profile and Platelet Function

Summary: on-pump cabg surgery deleteriously affects hematological and coagulation profiles of patients and this effect was accentuated by the use of cold bypass. po altered platelet may count and function and prolonged clotting times correlates with amount of daily po blood wound drainage and number of blood products units used, but prolonged aptt is the best predictor for these events.

background: the use of cardiopulmonary bypass during cardiac surgery negatively affects the coagulation system. hypothermia is also known to inhibit the coagulation profile. the aim of the study is to assess and compare the early postoperative (po) haematological and coagulation profile of patients undergoing coronary artery bypass graft (cabg) surgery with hypothermic (ht) versus normothermic (nt) bypass methods: eighty-six patients were divided into two equal groups: nt group included patients received warm bypass and using warm blood cardioplegia from bypass and ht group included patients received cold bypass and using cold cardioplegia given by the anaesthesiologist. po monitoring included the activated clotting time (act) prior to wound closure and 2-hr changes in the haemoglobin concentration (hb), platelet count (pc), adp-induced platelet aggregation (ipa), inr in relation to preoperative profile and amount of po daily blood loss and number of transfused blood units. the primary outcome was the po alternations in the coagulation and haematological profile. the secondary outcome was the amount of po daily bleeding, number of transfused blood units and incidence of re-opening surgery due to bleeding.

Eligibility criteria:
inclusion criteria: 1. ischemic heart disease patients 2. both genders 3. aged 50 - 65 years 4. assigned for first-time, elective and isolated on-pump cabg surgery. exclusion criteria: 1. pre-existing coagulopathy 2. hemostasis disorders, 3. anemia, 4. redo or emergency cabg, re-exploration for surgical-cause po bleeding, other associated pathologies, hepatic or renal impairment and/or maintenance on antiplatelet therapy during the last 10 days prior to surgery
pre-operative aqueous antiseptic skin solutions in open fractures

Conditions: Surgical Site Infection; Unplanned Fracture-Related Reoperation; Open Appendicular Fracture

Summary: the prevention of infection is the single most important goal influencing peri-operative care of patients with open fractures. standard practice in the management of open fractures includes sterile technique and pre-operative skin preparation with an antiseptic solution. the available solutions kill bacteria and decrease the quantity of native skin flora, thereby decreasing surgical site infection (ssi). while there is extensive guidance on specific procedures for prophylactic antibiotic use and standards for sterile technique, the evidence regarding the choice of antiseptic skin preparation solution is very limited for open fracture surgery.


Eligibility criteria:
the inclusion criteria are: 1. patients 18 years of age or older. 2. open fracture of the appendicular skeleton. 3. received or will receive definitive fracture treatment with a surgical implant(s) (e.g., internal fixation, external fixation, joint prosthesis, etc.). 4. open fracture wound management that includes formal surgical debridement within 72 hours of their injury. 5. will have all planned fracture care surgeries performed by a participating surgeon or delegate. 6. informed consent obtained. 7. patient enrolled within 3 weeks of their fracture. the exclusion criteria are: 1. patients that did not or will not receive the allocated pre-operative surgical preparation solution due to a medical contraindication. 2. received previous surgical debridement or management of their open fracture at a non-participating hospital or clinic. 3. open fracture managed outside of the participating orthopaedic service (e.g., hand fracture managed by plastic surgeon). 4. chronic or acute infection at or near the fracture site at the time of initial fracture surgery. 5. burns at the fracture site. 6. incarceration. 7. expected injury survival of less than 90 days. 8. terminal illness with expected survival less than 90 days. 9. previous enrollment in a prep-it trial. 10. currently enrolled in a study that does not permit co-enrollment. 11. unable to obtain informed consent due to language barriers. 12. likely problems, in the judgment of study personnel, with maintaining follow-up with the patient. 13. excluded due to sampling strategy.

Keywords: surgical site infection open fracture povidone-iodine chlorhexidine gluconate peri-operative preparation solutions
the effects of dry needling on the superficial neck musculature

Conditions: Neck Pain

Summary: the term myofascial pain refers to the existence of myofascial trigger points (mtp), which are defined as hypersensitive points in a tense band of skeletal muscle, which can cause referred pain or autonomous phenomena. to address the treatment of myofascial trigger points, conservative and invasive techniques have been proposed. dry needling is one of the invasive techniques that have been shown to be effective in improving pain and function in patients with myofascial trigger points. this trial aims to analyse the effectiveness of dry needling in patients with myofascial neck pain.

the main objective of the study is to analyze the effects of dry needling on the superficial neck musculature in patients with chronic myofascial neck pain in terms of pain, functional capacity, mobility, psychosocial variables and motor control compared with both sham dry needling group and control group. in addition, a secondary objective is to analyze the relationships between the psychosocial variables and the results obtained in the variables analyzed in the patients belonging to the three groups. for this purpose the investigators conduct a randomized controlled trial double-blind. patients included are randomized into 3 groups. one receives dry needling, another one receives sham dry needling, and the last one is a control group. the hypothesis of this study is that patients in the real dry needling group will improve more compared to patients in the sham dry needling group and the control group.

Eligibility criteria:
inclusion criteria: * patients with myofascial neck pain * presence of at least one active myofascial trigger point on the superficial neck musculature * neck pain of at least 3 months * age 18-70 * pain intensity between 20 and 100 mm in the analog visual scale * neck disability index (ndi) greater than or equal to 15 points * spanish speakers * patients who do not present contraindications for the use of dry needling (anticoagulants, nickel allergy or belenophobia) * patients who have not received physiotherapy or pharmacological treatment for neck pain for the last three months exclusion criteria: * history of cervical trauma * cervical spine surgery * vertebral fracture * cervical pain associated with whiplash * red flags (tumor, metabolic disorders or rheumatoid arthritis) * inflammatory lesion in the neck region * pregnancy * fibromyalgia diagnosis * neck pain associated with radiculopathy * patients pending legal litigation * psychiatric pathology diagnosis

Keywords: physical therapy
moxonidine in patients undergoing vascular surgery

Conditions: Cardiac Disease; Vascular Surgery

Summary: investigating the perioperative effect of moxonidine. in a randomized double-blind fashion, patients undergoing vascular surgery will receive moxonidine 0.2 mg or placebo from the day before surgery until day 4 after surgery. holter-ekg for 48 h, starting just before surgery. repeated 12-lead ekg, measurements of troponin i and bnp, clinical visitations, follow-up interviews at 6 and 12 months


Eligibility criteria:
inclusion criteria: * abdominal aortic or peripheral vascular surgery exclusion criteria: * unstable angina, * severe symptomatic heart failure (nyha iv) * systolic blood pressure at rest \< 100 mmhg * bradycardia (\<50/min) * higher grade av heart block * creatinine clearance \< 30 ml/min * pregnancy * no consent
clinicopathological parameters of her2 low breast cancers

Conditions: HER2 Low Breast Cancers

Summary: this was a retrospective cohort study which included all histologically proven cases of breast cancer in the 2 years from january 2022- december 2023 at a tertiary care centre. this study was performed in line with strocss criteria. the following clinicopathological data was retrieved from the histopathological records- age, tumor size, nodal involvement, lymphovascular/ perineural invasion, and bloom richardson grading. routine histopathological processing was done followed by immunohistochemical analysis for er, pr, her2, ki67 and ar. all the cases were categorised into luminal a, b, her2 enriched and triple-negative breast cancer based on the surrogate molecular classification. further, all the cases were categorised into her2 negative (no staining or incomplete weak membrane staining in ≤10% tumor cells), her2 3+ (complete membranous staining) and her2 low (1-2+ staining without amplification on ish) based on consensus of two pathology consultants. the present study aims to evaluate the clinicopathological parameters of the her2 low breast cancers.


Eligibility criteria:
inclusion criteria: * all histologically proven cases of breast cancer in the 2 years from january 2022- december 2023 exclusion criteria: * benign breast tumors
preoperative and intraoperative sonographic assessment of lower uterine segment thickness at term in women with previous cesarean delivery - a ultrasound method comparison study

Conditions: Scar; Previous Cesarean Section

Summary: this prospective, clinical, observational study compares preoperative and intraoperative sonographic assessment of lower uterine segment of women who underwent ≥ second cesarean section. it is the purpose of the study to assess transabdominal (linear/convex ultrasound probe) and transvaginal approach versus intraoperative sonographic assessment of lower uterine segment.

in 1991, 126.297 (15.3%) women delivered by caesarean section in germany. since then, the rate of caesarean section increased steadily over the next 20 years, reaching up to 32.2% in 2011 \[https://www.destatis.de\]. the absolute risk of uterine rupture in vaginal birth after caesarean section is 1 in 100 deliveries. the risk of perinatal death or the outcome of extremely neurological impairment is 1 in 1000 deliveries \[cunningham et al., 2009\]. statistically more than 300 pregnant women with a prior caesarean delivery visit daily ultrasound departments of german hospitals to investigate the c-section scar before delivery. they have one important question: is it possible to predict successful trial of labor after cesarean delivery? \[aqua-institut\] the information for the risk of uterine rupture remains insufficient based only on ultrasonography assessment \[varner et al., 2012\]. the measurement technique for lower uterine segment (myometrial) thicknesses in the third trimester have been described by several authors. using a combination of preoperative transvaginal and transabdominal (linear/convex probe) ultrasound, we compare with intraoperative sonographic assessment of lower uterine segment of women who underwent ≥ second cesarean section. the aim of the present study is to assess transabdominal (linear/convex ultrasound probe) and transvaginal approach versus intraoperative sonographic assessment of lower uterine segment. this will allow the investigators to draw conclusions regarding the best method to assessment of lower uterine segment (myometrial) thickness in the third trimester to predict successful trial of labor after cesarean delivery.

Eligibility criteria:
inclusion criteria: * pregnancy after previous cesarean section * pregnancy between 37 0/7 and 42 0/7 weeks of gestation * primary or secondary indication for cesarean section * ability to give informed consent in german or english exclusion criteria: * emergency caesarean section * \<18 years old

Keywords: caesarean section lower uterine segment sonography
comparison of pain levels in fusion prostate biopsy and standard trus-guided biopsy

Conditions: Pain Due to Certain Specified Procedures; Prostate Cancer; Biopsy

Summary: the aim of this study was to compare the pain levels in transrectal ultrasound (trus)-guided standard 12-core prostate biopsy (spb) and multiparametric prostate magnetic resonance imaging (mpmri)-guided fusion prostate biopsy (fpb).

the study included patients that underwent prostate biopsy under local anesthesia (intrarectal 2% lidocaine gel + periprostatic nerve block) due to suspected prostate cancer. patients detected with a prostate imaging reporting and data system score (pirads) ≥3 lesion on mpmri underwent mpmri-guided fpb (group i) and the patients who had no suspected lesions or had a pi-rads \<3 lesion on mpmri underwent trus-guided spb (group ii). pain assessment was performed using visual analog scale (vas) 5 min after the procedure. following the procedure, the patients were asked to indicate the most painful biopsy step among the three steps (1: insertion of the probe into the rectum, 2: probe manipulation, 3: the piercing of the biopsy needle).

Eligibility criteria:
inclusion criteria: * elevated blood prostate specific antigen (psa) levels according to patients age. psa \>2ng/ml for whom aged between 50-60, and psa \>4ng/ml for whom were above 60 years old * having suspicious digital rectal examination * having multi-parametric prostate mri before prostate biopsy * having mri defined lesions which were pirads - 3 -4-5 exclusion criteria: * psa \> 50 ng/ml * previous negative biopsy * neurological disorders that could affect the pain level such as paraplegia or hemiplegia, analgesics use for any reason on the day of or the day before the procedure, * patients underwent biopsy under general anesthesia, * having such diseases as anal fissure or hemorrhoidal disease that could alter the pain threshold

Keywords: fusion prostate biopsy pain