Kornimate/medical-research-clean huggingface dataset:
aortic valve-sparing root replacement, according to the inclusion technique described by tirone david

Conditions: Aortic Root Aneurysm; Aortic Regurgitation

Summary: retrospective observational study of all patients undergoing aortic root surgery with aortic valve conservation, using the inclusion technique described by tirone david, between january 1, 2004 and december 31, 2020, at six centers (nantes - rennes - brest - angers - tours \[two centers\]). the main objective of this study is to evaluate the survival without re-intervention for aortic valve dysfunction (surgery or tavi).

retrospective observational study of all patients undergoing aortic root surgery with aortic valve conservation, using the inclusion technique described by tirone david. inclusion criteria: patients undergoing aortic root surgery with conservation of the aortic valve, according to the inclusion technique described by tirone david, between january 1, 2004 and december 31, 2020, at one of the six centers: nantes, rennes, brest, angers, tours (two centers). non-inclusion criteria: prosthetic replacement of the aortic valve intraoperatively during the first operation. objectives and endpoints : * the survival without re-intervention for aortic valve dysfunction (surgery or tavi) * the overall cardiovascular survival * the survival without aortic insufficiency of grade equal to or greater than two * the survival without aortic infective endocarditis * assessment of long-term stroke risk assessment of the risk of a major bleeding event in the long term data analysis : the aortlantic study is included in the epicard registry which is the official, national database of the french society of cardiac surgery. study data will then be collected using epicard's electronic case report form (ecrf) and then analyzed using a multivariate cox model. for the follow-up, the wepi ecrf is used.

Eligibility criteria:
inclusion criteria: * patients undergoing aortic root surgery with conservation of the aortic valve, according to the inclusion technique described by tirone david, between january 1, 2004 and december 31, 2021, at one of the six centers: nantes, rennes, brest, angers,tours uh. non inclusion criteria : * prosthetic replacement of the aortic valve intraoperatively during the first operation.

Keywords: valve-sparing aortic root replacement david procedure acute aortic dissection aortic regurgitation bicuspid aortic valve french multicentric registry
neuraxial anesthesia and restless leg syndromes in cesarean

Conditions: Cesarean Section; Restless Leg Syndrome

Summary: the restless leg syndromes is a common sensorimotor disorder of unknown cause affecting approximately 10% of the population. different literature had different views on the association between neuraxial anesthesia and the occurrence of restless leg syndrome. some reported that spinal anesthesia induced postoperative restless leg syndrome, but other studies showed that spinal and general anesthesia all two did not cause restless leg syndrome. a potential difference amongst these studies is that a big difference exists in surgical types. the investigators proposed that different types of surgery performed undergoing various anesthesia, and that there is a big difference in original pathophysiological condition. therefore, the investigators hypothesized that pregnant women who have special physical states would have had an association between neuraxial anesthesia and restless leg syndrome in such patients who received selective cesarean section undergoing spinal or epidural anesthesia.


Eligibility criteria:
inclusion criteria: * healthy pregnancy * selective cesarean * gestational age \>= 37 weeks * chinese exclusion criteria: * allergic to local anesthetics * allergic to opioids * history of psychosis * cognition malfunction * any organic diseases * original lower extremity dyskinesia and paraesthesia * chronic pain * difficult in sleep * drug and alcohol abuse

Keywords: restless leg syndrome spinal anesthesia epidural anesthesia neuraxial block
long-term outcome of the tvt procedure without preoperative urodynamic examination

Conditions: Stress Urinary Incontinence

Summary: a follow-up study of 191 patients operated on with the tvt procedure between january 1998 and may 2000 at the department of obstetrics and gynecology in the turku city hospital. after a mean of 10.5 years patients were invited to a follow-up visit. subjective outcome was evaluated with condition-specific and general quality of life and health questionnaires. objective outcome was evaluated with gynaecological examination and a supine stress test. objective cure was defined as a negative stress test and no need for a reoperation for sui and subjective cure.


Eligibility criteria:
inclusion criteria: * 191 patients operated on with the tvt procedure between january 1998 and may 2000 at the department of obstetrics and gynecology in the turku city hospital
correlation of peak tidal inspiratory flow measured before and after extubation in adult patients with hypoxemia

Conditions: Hypoxemic Respiratory Failure

Summary: in this study, patients who are ready for extubation and indicated for high-flow nasal cannula therapy after extubation will be enrolled, the investigators would measure the patient peak tidal inspiratory flow (ptif) pre and post extubation to explore the correlation between the two ptifs. moreover, different hfnc flows would be applied, to explore the patient response in terms of oxygenation and lung aeration to different flow ratios that matched and are above post-extubation ptif.

high-flow nasal cannula (hfnc) oxygen therapy has been shown to improve oxygenation, reduce the need for intubation for patients with acute hypoxemic respiratory failure (ahrf) and avoid reintubation for post-extubation patients who had high-risk factors. hfnc refers to the delivery of gas at flows that exceed the patient peak inspiratory flow during tidal breathing, however, patient peak tidal inspiratory flow (ptif) is found to vary greatly among different patients, from 20 to 50 l/min, making it difficult to properly set hfnc in a way to achieve the desired effects. in two recently published studies in intubated patients, ptif varied from 25-65 l/min or 40-80 l/min, thus this study aims to investigate the correlation between pre-extubation ptif in different modalities of sbt and post-extubation ptif for adult patients, who are indicated to use hfnc immediately after extubation. in addition, the investigators aim to explore the patient response in terms of oxygenation and lung aeration to different flow ratios that matched and are above post-extubation ptif.

Eligibility criteria:
inclusion criteria: * adult intubated patients aged between 18 to 90 years * pass spontaneous breathing trial and receive the order to be extubated * have at least one of the indications to use hfnc after extubation exclusion criteria: * need to use inhaled epoprostenol via hfnc * pregnant * unable to use resuscitation mask, such as facial trauma, claustrophobia * non-english speaker * inability to verbally communicate * using extracorporeal membrane oxygenation (ecmo) * hemodynamically unstable * difficult airway

Keywords: high-flow nasal cannula flow setting peak tidal inspiratory flow hypoxemia
the utility of virtual reality in the management of pediatric functional constipation with pelvic floor dysfunction.

Conditions: Functional Constipation; Pelvic Floor Disorders

Summary: 1. to determine if the adjunctive use of a virtual reality (vr) module on diaphragmatic breathing (db) can improve the quality of life (qol) and symptoms of children with functional constipation (fc) with pelvic floor dysfunction (pfd) who are receiving standard of care treatment. 2. to assess if a vr module on db can decrease healthcare utilization for children with fc with pfd.

the investigators will assess if the use a virtual reality (vr) module on diaphragmatic breathing (db) can improve quality of life, constipation symptoms, and decrease healthcare utilization for children with functional constipation (fc) with pelvic floor dysfunction (pfd). fc is a common pediatric condition with a high prevalence and $4.25 billion yearly in healthcare expenditures. fc is often complicated with pfd as seen through stool withholding behaviors. children with fc with pfd are referred to occupational therapy for biofeedback and db training as standard of care. occupational therapy uses to teach children with fc with pfd to relax their abdominal muscles, and subsequently their pelvic floor muscles, facilitating a more complete bowel evacuation. vr is a technology currently employed in rehabilitation services, anesthesiology and surgery. vr can provide a fun, immersive environment with a feedback component for children with fc to learn db effectively and build a positive association with toileting. the purpose of this study is to examine if a virtual reality module that teaches children diaphragmatic breathing through an immersive game can improve the quality of life and decrease health care utilization for children with functional constipation and pelvic floor dysfunction.

Eligibility criteria:
inclusion criteria: * ages 7 to 21 years old * meets rome iv criteria for functional constipation and pelvic floor dysfunction * developmentally appropriate to understand verbal instructions exclusion criteria: * co-existing medical conditions that include inflammatory bowel disease, hirschsprung's disease, cystic fibrosis, tethered cord, anal stenosis, sacral agenesis, spinal cord anomalies, untreated thyroid disease, untreated celiac disease, neurogenic bowel, cerebral palsy, major bowel surgery. * non-english speaking
self-management of type 1 diabetes under functional insulin therapy

Conditions: Type 1 Diabetes; Basal-bolus Multiple-dily Insulin Injections; Insulin Pump (CSII)

Summary: therapeutic education of patients is a mandatory component of intensive insulin therapy of type 1 diabetes in order to reach optimal safety and efficacy. used educational methods aim at facilitating patients' autonomy in their own management of diabetes. therefore, self-management of patient with type 1 diabetes must be systematically assessed in order to evaluate the effectiveness of education programs .the main objective of this prospective controlled randomized monocentric study is to assess the impact of functional insulin therapy on the level of self-management of patients with type 1 diabetes via confidence in diabetes self-care scale (cids) test.

170 patients with type 1 diabetes, volunteering for education to functional insulin therapy, will be recruited by the department od endocrinology, diabetes, nutrition of montpellier university hospital. after inclusion, the patients will be randomized in 2 groups: group 1 will be immediately trained to functional insulin therapy and group 2 will be trained at the end of the study. the patients will be met as outpatients 3 months after inclusion. the primary endpoint will be the global score for cids questionnaire. secondary endpoints will include: hba1c level at month 3, frequency of hypoglycemia from inclusion to month 3, scores for each of the 20 items of cids questionnaire. an ancillary study will assess: the acceptability of the new ead questionnaire which specifically evaluates the self-management of diabetes, the concordance validity of ead and cdis questionnaires, the reproducibility test-retest, the internal consistency and the sensitivity to change of ead questionnaire.

Eligibility criteria:
inclusion criteria: * type 1 diabetes from at least 1 year * age from 18 to 70 (70 not included) * basal-bolus multiple-dily insulin injections or insulin pump (csii) * informed consent * affiliated or benefit from an insurance regimen exclusion criteria: * type 2 diabetes * unable to make mathematic calculation * pregnancy, breast-feeding or absence of effective contraception * psychiatric and/or cognitive status uncompatible with study * eating disorders * law protected person, vulnerable person

Keywords: therapeutic education functional insulin therapy
interaction between omeprazole and gliclazide in cyp2c19 normal/ ultrarapid metabolisers

Conditions: Diabetes Mellitus, Type 2

Summary: proton pump inhibitors (ppis) are treatment of choice for different gastrointestinal disorders common in type 2 diabetes. sulfonylureas (sus) are anti-diabetes agents particularly widely used in developing countries. gliclazide, a recommended su drug, is metabolised in part by cyp2c19, the main enzyme responsible for the ppi metabolism. a randomised, placebo-controlled, two-sequence, two-period crossover study will be performed to explore whether gliclazide pharmacokinetics (pk) and pharmacodynamics (pd) are altered upon co-administration with omeprazole. sixteen healthy volunteers, cyp2c19 extensive/ultrarapid metabolisers (em/um), will receive placebo or omeprazole alone for 4 days, and concomitantly with single dose of gliclazide on day 5. plasma concentration of gliclazide will be measured for 24 hours, and plasma glucose and insulin levels up to 12 hours after gliclazide administration.


Eligibility criteria:
inclusion criteria: * men * age 18-30 years * non-smokers * cyp2c19 extensive/ultrarapid metabolisers exclusion criteria: * medical history of hepatic, renal, gastrointestinal and hematologic disease or any acute or chronic disease, or drug allergy to sulfonylureas or ppis or history of drug abuse * abnormalities in physical examination, ecg and routine clinical laboratory tests (including fasting blood glucose concentration) * medication use during the 14 days prior and during the study period * grapefruit, grapefruit juice, alcohol, beverages or food containing methylxanthines use during 72 h prior and during the study period
relationships between toddlers with feeding disorder and spd and their parents

Conditions: Feeding and Eating Disorders of Childhood; Developmental Disabilities

Summary: the researched attends to observe the relationships between toddlers that were diagnosed as spd and as having feeding disorder (by dsm-r-iv)and their parents.


Eligibility criteria:
inclusion criteria: * toddlers aged between one year to two and a half years * toddlers diagnosed as spd by occupational therapist * toddlers diagnosed as having feeding disorder by psychiatric physician according to dsm-r-iv * toddlers that are normally developed as reported by pediatrician exclusion criteria: * compliant families * toddlers with poor health

Keywords: toddlers that having feeding disorders and spd
arabic version of a new tool called heal-command to evaluate hearing loss and communication and conversation disability

Conditions: Hearing Loss

Summary: hearing loss is the fourth highest cause of disability globally. current data suggest that approximately 5% of the world's population suffer from disabling hearing loss, earlier studies have shown that persons with hearing loss experience a higher prevalence of associated adverse health effects than persons with normal hearing. those conditions include social isolation, depression, diabetes, dementia, falling, cardiovascular disease, and reduced quality of life. a limitation to disability-based questionnaires related to hearing loss is the large number of instruments available and the lack of consensus on which questionnaires to use. to do so, applying the world health organization's international classification of functioning disability and health (icf) framework was found to be an ideal design foundation. in the icf, functioning refers to positive aspects of body functions, activities, and participation, while disability refers to impairments, activity limitations, and participation restrictions, in which both aspects can be influenced by a health condition(s) and or contextual (personal and environmental) factors. previous studies showed that the operationalization of the icf core sets for hl into a self-assessment tool can serve as the foundation for a comprehensive picture of health. to accommodate this need, a collaboration between group of researchers at audiology clinic, auburn university, alabama, usa have been conducted. this partnership resulted in creating an english and german version of questionnaire that comprehensively assesses and individuals hearing functioning profile according to icf framework which is called heal-command tool


Eligibility criteria:
inclusion criteria: 1. age between 30-80 years 2. new individuals who presented to the speech and hearing clinic with ear or hearing complaints and showed the following pattern/s: * normal hearing with subjective hearing difficulties * mild hearing loss * moderate hearing loss * new hearing aid users or experienced hearing aid users 3. adequate cognitive and comprehension abilities to complete the questionnaire and cognitive interview session. 4. ability to attend remote activities exclusion criteria: 1. age under 30 or over 80 years 2. illiterate who can't complete the questionnaire or digital forms 3. clinical diagnosis with depression and cognitive decline or dementia 4. above moderate hearing loss
low-dose spinal morphine for post-thoracotomy pain after video-assisted thoracoscopic surgery

Conditions: Video-assisted Thoracoscopic Surgery

Summary: one-thirds of patients underwent video-assisted thorascopic surgery still have severe pain. therefore we want to demonstrate weather 0.15 mg spinal morphine would reduce 24 hour postoperative requirement comparing to control group.


Eligibility criteria:
inclusion criteria: * asa (american society of anesthesiologist) physical status i to iii, * undergoing elective video-assisted thoracoscopic surgery at siriraj and thammasart hospitals * capable of using a patient-controlled analgesia (pca) machine * understanding the numeric rating scale (nrs) score for pain assessment. exclusion criteria: * history of allergy to the study drugs * bleeding disorder * infection of the back * refusing spinal anesthesia * history of cerebrovascular disease * using postoperative ventilator support were excluded

Keywords: postoperative pain spinal morphine video-assisted thoracoscopic surgery
effect of guided imagery on patients with chronic pain related to spinal cord injury

Conditions: Pain

Summary: chronic pain after spinal cord injury in or below the level of injury is a common problem and can be severe. the purpose of our study is to investigate the effect of pleasant guided imagery on spinal cord injured patients with chronic pain in or below the level of injury.

the study is a controlled simple blind randomized prospective study. subjects who live in trøndelag ( norway) and who have a traumatic or non traumatic spinal cord injury with chronic pain in or below the level of injury will be included in the study. assessments: pain will be measured with nrs(numeric pain rating scale) and bpiq (brief pain intervention questionnaire), anxiety and depression with bdi and bai (beck's depression and anxiety inventory) and quality of live with sf36 health survey. the subjects will be randomized in a treatment and control group. one group will use daily for four weeks a cd with a pleasant guided imagery, the other group will write a short pain diary. the nrs will be registered daily and the other assessments before and after the interventions.

Eligibility criteria:
inclusion criteria: * traumatic and non traumatic sci (spinal cord injury) persons in trøndelag (norway) exclusion criteria: * not sufficient knowledge of the norwegian language, cancer, serious cognitive impairment, abuse or dependence of alcohol, narcotics or analgesics and dissociative disorder
the effect of a liraglutide on ivf in obese pcos

Conditions: Polycystic Ovary Syndrome; Obesity; Infertility, Female

Summary: the aim of this study was to evaluate the impact of low dose liraglutide in combination with metformin compared to metformin alone on ivf pregnancy rate (pr) and cumulatively pr (ivf and spontaneous) in infertile obese women with pcos who had been previously poor responders regarding weight reduction with lifestyle modification and resistant to first line reproductive treatments.

polycystic ovary syndrome (pcos) is the most common cause of anovulatory infertility, in particular when pcos is linked to obesity. obese pcos has poor ivf outcomes associated with impaired oocyte and embryo parameters and morphology. the purpose of this pilot prospective study was to investigate the effect of the novel medical therapy (combination of metformin and liraglutide (combi)) in the specific infertile obese pcos population. glp-1 has been investigated in regulation of reproductive system in animal models. current observations suggest that it directly regulates kisspeptin and gnrh expression and that ovaries express glp-1 mrna. in obese pcos, glp-1 receptor agonist liraglutide provided positive effects on weight reduction and glucose homeostasis

Eligibility criteria:
inclusion criteria: * 18 years old to 38 years old * polycystic ovary syndrome (rotterdam criteria) * bmi of 30 kg/m² or higher * infertility * before ivf exclusion criteria: * type 1 or type 2 diabetes mellitus * history of carcinoma * cushing's syndrome or congenital (non-classic) adrenal hyperplasia * personal or family history of men 2 * significant cardiovascular, kidney or hepatic disease * the use of medications known or suspected to affect reproductive or metabolic functions * the use of statins, within 90 days prior to study entry no other ovarian pathology normal male semen

Keywords: polycystic ovary syndrome obesity infertility ivf
a pilot open-label randomized study of lactofiltrum in women with bacterial vaginosis

Conditions: Bacterial Vaginosis

Summary: this is a phase ii multicenter randomized open-label clinical study that will determine whether treatment with lactofiltrum (orally administered tablets) in combination with antibiotic therapy (metronidazole) is effective in women with bacterial vaginosis. lactofiltrum is a composite drug that includes enterosorbent lignin and prebiotic lactulose. it's supposed that supplement of lactofiltrum to a standard therapy of bacterial vaginosis (metronidazole administered orally) improves women's general state, leads to better recovery of clinical, microbiological, biochemical and histological features of the disease.


Eligibility criteria:
inclusion criteria: * bacterial vaginosis. exclusion criteria: * pregnancy and breast-feeding; * concomitant infection diseases; * systemic or topical treatment with antibiotics, steroids, immunosuppressive, cytostatic or antimetabolite agents by the time of inclusion; * application of intravaginal medicines during participation in the study; * severe diseases; * renal and hepatic failure; * application of pre-, probiotics and antibiotics 2 weeks before inclusion or during participation in the study; * participation in other clinical study 1 month before inclusion or during participation in the proposed study.

Keywords: vaginosis, bacterial prebiotics lactofiltrum therapy