Kornimate/medical-research-clean huggingface dataset:
trajectory of recovery in the elderly

Conditions: Delayed Emergence From Anesthesia; Postoperative Delirium; Postoperative Cognitive Dysfunction

Summary: the purpose of this study is to understand how elderly individuals regain their cognitive skills following general anesthesia. the investigators will compare an age stratified group of volunteers who will be evaluated with a series of cognitive tests and a functional mri. the participants will then be administered general anesthesia for two hours. the investigators will then assess the participants using state of the art tools to determine when participants return to their cognitive baseline.

elderly patients undergoing anesthesia and surgery frequently suffer from postoperative cognitive dysfunction (pocd) and postoperative delirium (pd). the cause of these entities is unknown. it is unclear what part anesthetics play in the development of pocd and pd. the investigators hypothesize that elderly patient's cognitive capacities recover more slowly after receiving general anesthesia, perhaps because they have more limited cognitive reserve. a more prolonged recovery would confound diagnoses of pocd and pd and potentially puts patients who are discharged on the day of surgery at risk of not understanding postoperative instructions. the trajectory of postoperative cognitive recovery has never been explored and elderly participants have been explicitly not included in any type of emergence research. to explore this vital area the investigators propose to study young and elderly volunteers with a combination of two state of the art neuropsychological tests (postoperative quality of recovery scale and the nih toolbox) and functional magnetic resonance imaging. starting from baseline, the investigators will determine multiple cognitive domains and resting state networks, treat the participants with general anesthesia for two hours while continuing to examine network activity, and then explore the recovery of the cognitive domains and alterations in functional networks using both the pqrs and the nih toolbox cognitive measures. participants will be evaluated at 1 month, 6 months, and 12 months.

Eligibility criteria:
inclusion criteria: * 40-80 years old * american society of anesthesiologists (asa) physical status i or ii (i.e. individuals with minimal disease burden) * capable and willing to consent exclusion criteria: * airway assessment as potentially difficult (mallampati iii or greater) * allergies or hypersensitivity to drug or class * chronic inflammatory conditions such a lupus or system rheumatoid arthritis (arthritis limited to 1 or 2 joints will be acceptable) * patients with diabetes mellitus * patients with a recent illness (within the last 2 weeks) * patients with severe visual or auditory disorder/handicaps * english illiteracy * pregnancy * participants not expected to be able to complete the postoperative tests * history of malignant hyperthermia * nursing mothers * body mass index \> 30 * patients with significant metal implants in body * current use of cocaine or opiates * current smokers

Keywords: general anesthesia, postoperative delirium, recovery
prospective database for prediction of atrial fibrillation in pacemaker and icd patients

Conditions: Atrial Fibrillation; Pacemaker Ddd; ICD

Summary: atrial fibrillation (af) is associated with a five-fold increased risk of cerebrovascular stroke. while the risk of stroke in patients with known af can be calculated via af stroke prediction risk scores, the prediction of af occurrence per se in individual patients remains difficult. we will recruit 250 patients with an implanted dual-chamber pacemaker (pm) or an implantable cardioverter defibrillator (icd) with atrial lead to ensure continuous rhythm monitoring during follow up. at baseline, we will gather clinical and device data of patients. for af prediction based on surface electrocardiography (ecg), 24-h holter ecg monitoring will be performed. after 6 months, we will assess the occurrence of af during the study period via interrogation of pm/icd. the resulting data will be used to develop algorithms including clinical, device and ecg data for prediction of the development of af in individual patients. if possible, we will develop a risk score of high accuracy by combination of demographical, clinical and technical parameters of device patients. the resulting risk score could potentially help to facilitate the decision if anticoagulation is necessary in patients with either risk of af or embolic stroke of unknown origin. furthermore, hayn et al. (ait austrian institute of technology) are currently developing algorithms to predict the occurrence of af surface ecg data. it is an additional aim of this project to support the development of this algorithm in pacemaker and icd patients and to increase the accuracy of af prediction with clinical parameters and other parameters available to patients with implanted pacemaker (pm) or implanted cardioverter-defibrillator (icd).


Eligibility criteria:
inclusion criteria: * implanted pacemaker or implanted cardioverter defibrillator (icd) with atrial lead * chads-vasc score of 2 or more * sinus rhythm or atrial paced rhythm * atrial stimulation rate 50% or less * modeswitch rate 50% or less since last pacemaker interrogation exclusion criteria: * pacemaker or icd malfunction * atrial fibrillation (af) at time of pacemaker / icd interrogation * af during 24-hour holter ecg monitoring * permanent af
does the cerebroplacental ratio (cpr) predict adverse outcomes in low risk pregnancies?

Conditions: Cerebroplacental Ratio

Summary: ultrasound doppler studies are used during pregnancy to help manage pregnancies complicated by fetal growth restriction. the cerebroplacental ratio may predict adverse outcomes in low risk pregnancies. in a prospective study, the investigators will examine whether fetuses with an abnormal cpr at or near term are at increased risk for being delivered by cesarean,

this is a multicenter prospective study of low-risk nulliparous women who will be recruited if they are having an ultrasound at 36 weeks of estimated gestational age or greater. as part of the study, women will have umbilical and middle cerebral artery doppler studies and the cpr will be calculated by dividing the middle cerebral artery pi by the umbilical artery pi. providers caring for study subjects will be blinded to this result. pregnancy outcomes in women with cpr values less than the 10th percentile for gestational age will be compared to those with cpr values above the 10th percentile. a secondary aim of the study is to analyze cpr as a continuous variable.

Eligibility criteria:
inclusion criteria: * nulliparous pregnant women between the ages of 18 and 45 years with low risk pregnancies who present for obstetrical ultrasound at 36 weeks of gestation or later with a planned delivery at a perinatal research consortium hospital. exclusion criteria: * multifetal pregnancy at the time of presentation * known fetal chromosomal anomaly * known fetal malformation * preeclampsia * fetal growth restriction * multiparity * prior cesarean section * placental abnormalities such as previa or accreta * pregestational diabetes * plan to deliver outside the perinatal research consortium affiliated hospitals

Keywords: biophysical profile cesarean section estimated fetal weight middle cerebral artery umbilical artery fetal growth restriction pulsatility index estimated gestational age doppler
trans nasal insufflation for the treatment of snoring

Conditions: Obstructive Sleep Apnea

Summary: this research is being done to examine if a nasal cannula can be used to keep the throat open during sleep, thereby treating sleep apnea. people with sleep apnea and people who snore without sleep apnea may take part in this study. sleep apnea is a disorder caused by pauses in breathing due to repetitive closure of the throat. the most common form of treatment for sleep apnea is continuous positive airway pressure (cpap) therapy. while cpap therapy remains the simplest and most effective treatment for snoring and sleep apnea, patients have to wear a nasal mask throughout the night. for this reason, patients often have difficulty sticking to therapy. participants enrolled in this study will spend 3-nights in a sleep laboratory. in all nights, the investigators will monitor your sleep and your breathing throughout the night. the investigators will apply several electrodes (sensors) to your scalp and face to monitor your sleep and breathing, and other sensors to your chest, abdomen, cheek, and a finger to monitor your breathing and oxygen level.


Eligibility criteria:
inclusion criteria: * consenting adults over the age of 21 * diagnosed obstructive sleep apnea exclusion criteria: * unstable cardiovascular disease * uncontrolled hypertension (bp \> 190/110) * severe intrinsic lung diseases (supplemental o2 \> 2 l/min during the day) * history of chronic renal insufficiency * history of hepatic insufficiency * pregnancy * bleeding disorders or coumadin use * sleep disorders other than obstructive sleep apnea (osa) * tracheostomy * allergy to lidocaine

Keywords: sleep apnea snoring sleep apnea treatment tni trans nasal insufflation open cpap
myo-inositol, d-chiro-inositol, and d-chiro/myo-inositol in gestational diabetes

Conditions: GDM

Summary: comparison of different inositol stereoisomears in preventing adverse obstetric outcomes in non-obese pregnant women at high risk for gestational diabetes mellitus.

the investigators compared outcomes from metabolic and obstetric point of view in gdm pregnant non-obese patient with different stereoisomears of inositol supply. dietary control and placebo or inositol steroisomears were administered starting at the enrolling time (first fasting oral glucose above 92 mg%; usually before 20 weeks gestations') till the delivery and/or pregnancy end/termination. oral glucose tolerance test results at 24-28 weeks' gestation was evaluated (as glucose values and ogtt screening). fetal growth, delivery data, obstetric outcomes and necessity of insulin therapy were taken into account.

Eligibility criteria:
inclusion criteria: * pregnancy below 20 weeks gestation bmi below 30 fasting glucose between 92 and 126 mg% singleton pregnancy naturally conceived exclusion criteria: * obese patient fasti g glucose above 126 or below 92

Keywords: inositol gdm
clinical readiness skin punch biopsy sample collections

Conditions: Congenital Heart Disease (CHD); Congenital Heart Defect

Summary: this is a clinical readiness skin punch biopsy sample collection study. this will allow to reduce manufacturing time when patients are identified as eligible to receive product under separate interventional treatment protocol.

this is a clinical readiness skin punch biopsy sample collection study. this will allow to reduce manufacturing time when patients are identified as eligible to receive product under separate interventional treatment protocol.

Eligibility criteria:
inclusion criteria: * age 18 and older * congenital heart disease * likely to qualify for an active clinical trial under ind 28611 in the future exclusion criteria: * previous cardiac transplantation * unable or unwilling to consent * hiv diagnosis * hepatitis diagnosis

Keywords: chd congenital heart defect
m.i.p.o. vs intramedullary nailing in tibia fractures

Conditions: Tibia Fracture

Summary: the investigators are comparing two methods of standard treatments in distal tibial fractures. locked plating (m.i.p.o. technique) with intramedullary nailing. the investigators are hypothesizing that m.i.p.o group is superior to nailing in fractures of the distal third of the tibia.

the kind of plates the investigators are comparing are the locked plates form synthes ® using the minimally invasive technique vs the expert tibial nail® from synthes ®

Eligibility criteria:
inclusion criteria: * males and females aged from 18-60 years * closed tibia fracture * tibia fracture müller ao class 43-a exclusion criteria: * intra-articular fractures * open fractures * fracturessubjects with documented marfan's syndrome or ehlers-danlos syndrome or hajdu-cheney syndrome. * post organ transplant patients (except cornea transplant) * subjects on immunosuppressive medications * subjects with diagnosed with * osteogenesis imperfecta * osteopetrosis * paget disease of bone * renal osteodystrophy * subjects with diagnosed neoplasms or mitotic illnesses * subjects receiving growth hormone * unable to comply with postoperative rehabilitation e.g. head injury * impending compartment syndrome

Keywords: fractured tibia expert tibial nail minimally invasive plate osteosynthesis (m.i.p.o) intramedullary nailing locked plate distal third 43-a
wearable electrocardiogram monitoring device and smartphone application in perioperative pain management

Conditions: Pain, Postoperative

Summary: this study aims to develop a wearable electrocardiograph monitoring device and smartphone application in perioperative pain management, also to evaluate relationship between postoperative pain and heart rate variability.

this study is a prospective observational cohort study implementing wearable electrocardiogram (ecg) monitor device and smartphone application in perioperative pain management. patients undergoing major abdominal surgical procedures will be recruited to wear a ecg monitor device from the day before surgery until 1-3days after surgery. patients will report their condition of pain twice daily on the corresponding smartphone application based on a structured and visualized pain report module. patients will receive a telephone follow-up 30/60/90/365 days after surgery for assessment of postoperative chronic pain. a pilot study will be conducted to evaluate acceptability, safety and feasibility of the device and application using system usability scale and comprehensive product quality assessment. further study will be conducted to evaluate the relationship between postoperative acute and chronic pain and heart rate variability (hrv) acquired from ecg device.

Eligibility criteria:
inclusion criteria: * patients undergoing major abdominal surgical procedures; * 18-65 years old; * asa classification: i-iv * able to read and understand how to use the app after instruction； * written informed consent obtained. exclusion criteria: * current participation in other mobile device research or perioperative pain research; * inability to use the device; * inability to obtain consent.

Keywords: heart rate variability postoperative pain
multiple-dose study to evaluate the safety,tolerability, pharmacokinetics and pharmacodynamics of hsk7653 in t2dm

Conditions: Type 2 Diabetes Mellitus

Summary: to evaluate the safety, tolerability and pharmacokinetic (pk)/pharmacodynamic (pd) characteristics of hsk7653 tablets in type 2 diabetes mellitus patients.


Eligibility criteria:
inclusion criteria: * age ≥18 and age ≤70 years * t2dm patients, * control the blood glucose level only with diet and exercise in last 3 months; * bmi ≥19 and bmi ≤ 35 kg/m2 (body mass index) * hba1c ≥7.0% and hba1c \<10.0% * fpg \<13.9 mmol/l exclusion criteria: * non-type 2 diabetes mellitus: type 1 diabetes mellitus, gestational diabetes history; * history of acute complications of diabetes (diabetic ketoacidosis, diabetic hyperglycemia hyperosmolar syndrome or lactic acidosis); * history of chronic complications of severe diabetes (retinal proliferative disease, severe diabetic neuropathy or intermittent claudication confirmed by fundus examination during screening); * patients who used systemic glucocorticoids within 3 months prior to screening had severe infections or major surgeries and transplants within 3 months; * three or more episodes of hypoglycemia occurred in the six months prior to screening; * history of hyperthyroidism within 6 months before screening; * severe cardiovascular disease. ; * medical conditions that may significantly affect drug absorption, distribution, metabolism, and excretion within 2 weeks prior to screening; * liver function tests abnormal; * moderate or severe renal impairment; * medical history or clinical evidence of pancreatic injury or pancreatitis, or abnormalities in lipase and amylase judged by investigators to be clinically significant; * patients with a history of hypertension who regularly take antihypertensive therapy for over 4 weeks still have poor control, sbp \> 160 mmhg and (or) dbp \> 100 mmhg; * patients with uncontrolled hyperlipidemia.
percutaneous electrolysis versus dry needling in levator scapulae

Conditions: Trigger Point Pain, Myofascial; Myofascial Pain

Summary: the objective will be to determine the effectiveness of ultrasound-guided percutaneous electrolysis versus ultrasound-guided dry needling in active myofascial trigger points of the levator scapulae muscle on pain intensity, disability and range of motion. a randomized clinical trial will be carried out. fifty-four patients with at least one active myofascial trigger point in the levator scapulae muscle were recruited and divided into ultrasound-guided percutaneous electrolysis (n = 27) and ultrasound-guided dry needling (n=27). pain intensity, disability and range of motion will measured before, immediately after and 1 week after intervention.


Eligibility criteria:
inclusion criteria: * neck pain * at least two active myofascial trigger point in the levator scapulae muscle exclusion criteria: * systemic diseases * cognitive impairment
blood/interstitial glucose measurements and cognitive function during hypoglycemia and recovery

Conditions: Hypoglycemia

Summary: the purpose of this study is to find out the effects of hypoglycemia on cognition in healthy individuals and how well changes in (interstitial) tissue glucose levels correlate with changes in cognitive function as compared to blood glucose levels.

subjects will undergo hypoglycemic clamps during which interstitial glucose will be measured and cognitive function will be assessed.

Eligibility criteria:
inclusion criteria: * non obese (bmi \<30), ages 18-50 exclusion criteria: * renal or hepatic failure * cancer or lymphoma * malabsorption or malnourishment * hypercortisolism * alcoholism or drug abuse * anemia * eating disorder or depression * coronary artery disease * arrhythmias * hypertension * on medications known to affect the blood glucose to be measured such as * glucocorticoids * on blood thinning agents * pregnant women, breastfeeding women and women who want to become pregnant in the next 6 months will be excluded from the study. * subjects who have donated blood two weeks prior to the study. * allergies to pig derived products (heparin will be used)

Keywords: hypoglycemia, cognitive function
analytic treatment interruption (ati) to assess hiv cure

Conditions: HIV

Summary: this study is designed to determine if individual patients with hiv infection have been cured of the infection. to do this, antiretroviral therapy is discontinued under close medical supervision and the patient monitored over time for reactivation of infection.


Eligibility criteria:
inclusion criteria * age ≥ 18 years * hiv-1 infected with the potential to have been cured of infection in the course of routine clinical care in the opinion of the treating physician and study team * have an undetectable plasma hiv-1 rna and undetectable proviral dna on suppressive antiretroviral therapy on at least two consecutive measures for at least 6 months * able and willing to either abstain from sexual activity or use barrier contraceptives during the ati * negative serum β-hcg pregnancy test in women with childbearing potential * have the ability to give appropriate informed consent. exclusion criteria * women who are pregnant or nursing * women who can become pregnant who are unable or unwilling to use both barrier and pharmacologic contraceptives during the ati * previous or current infections that are at high risk of reactivating with immune suppression, in whom there are no effective antimicrobial prophylaxis options * advanced cardiopulmonary or liver disease * history of untreated solid or hematologic malignancies * evidence of active viral replication in patients co-infected with hepatitis b virus (hbv). treatment should be provided to suppress hbv replication with agents that do not have activity against hiv (ie entecavir) prior to consideration for ati. * evidence of viral replication with hepatitis c virus (hcv), together with evidence of any hepatic fibrosis or inflammation. such patients should be offered hcv treatment first.

Keywords: cure analytic treatment interruption
tolerability study of trichostatin a in subjects with relapsed or refractory hematologic malignancies

Conditions: Relapsed or Refractory Hematologic Malignancies

Summary: the aim of this study is to investigate the safety and tolerability of trichostatin a in individuals with relapsed or refractory hematologic malignancies.


Eligibility criteria:
inclusion criteria: * subject is ≥ 18 years at the time of signing informed consent; * confirmed malignant hematologic disease or lymphoid malignancy that has relapsed or is refractory to standard therapy and has exhausted all available therapies; * presence of measurable or evaluable disease; * eastern cooperative oncology group (ecog) performance status of ≤ 2; * contraceptives or other approved avoidance of pregnancy measures exclusion criteria: * allogeneic stem cell transplant recipient presenting with graft versus host disease (gvhd) either active or requiring immunosuppression; * concomitantly taking anti-cancer therapy (bisphosphonates are permitted); * undergone major surgery ≤ 2 weeks prior to starting study drug; * evidence of mucosal or internal bleeding; * impaired cardiac function or conduction defect; * concurrent severe and/or uncontrolled medical conditions

Keywords: hematologic malignancies cancer blood
diagnostic protocol of painful hip

Conditions: Hip Fracture

Summary: nondisplaced hip fractures may be radiographically occult and require mri or single photon emission ct bone scintigraphy for accurate diagnosis. both examinations are expensive and are not readily available in many hospitals. ultrasound (us) examination is relatively inexpensive and preliminary data had demonstrated its efficacy in detecting occult fractures in other sites. our objective is to evaluate us examination as a screening tool for occult hip fractures in posttraumatic painful hips in the elderly.


Eligibility criteria:
inclusion criteria: 1. men and women above 40 years old 2. trauma to the hip . 3. extreme difficulty in walking or inability to step on the leg, following sensitivity in the hip joint area after local pressure or in a movement. 4. x ray of the pelvis aimed to the suspected hip joint (including ap lateral position and internal rotation) does not demonstrate fracture in the joint or the pelvis. exclusion criteria: 1. none
treatment of adult adhd with atomoxetine or atomoxetine and buspar

Conditions: Attention Deficit Disorder With Hyperactivity

Summary: determine if there is a difference in treatment response for adults with adhd who are treated with strattera versus those treated with a combination of strattera and buspirone


Eligibility criteria:
inclusion criteria: * adults with adhd exclusion criteria: * other axis i psychiatric disorders