Kornimate/medical-research-clean huggingface dataset:
tadalafil for treatment of priapism in men with sickle cell anemia

Conditions: Sickle Cell Anemia; Priapism

Summary: this research is being done to compare the effect of tadalafil with placebo (an inactive substance that looks like the study drug, but should have no effect) on the frequency of recurrent priapism (prolonged erection, unassociated with sexual interest or desire) and the nature of sexual experiences in male patients with sickle cell disease.

this study will investigate phosphodiesterase 5 (pde 5) inhibitor therapy as a potential treatment for recurrent ischemic priapism. enrolled participants will be randomized to receive oral 10 mg tadalafil tablets 3 times a week or receive matching placebo. patients will be instructed to use the medication in the morning a few hours after awakening from night time sleep, and they will be instructed against engaging in any form of sexual activity or excitement within 8 hours of dosing. treatment duration will be 2 months for each participant. after the 2 month period, participants on tadalafil and placebo will be offered tadalafil (same dosing regimen) for an additional 2 months. the study duration will be 4 months. tests and procedures will include: consent; medical history; physical examination; clinical laboratory tests; completion of questionnaires; and medication dispensation.

Eligibility criteria:
inclusion criteria: * all men (18 years of age and older) with actively recurrent ischemic priapism, defined as multiple, self-limited erectile events (characteristically less than 3 hours in duration) occurring repeatedly at least twice a week in the absence of sexual interest or desire may be considered for enrollment * able to swallow whole tablets equivalent to capsule size 0 * available for protocol-specified visits and procedures exclusion criteria: * history of refractory-type priapism * history of drug or alcohol abuse * currently smokes or has a 20 pack-year history of cigarette smoking * take any medications called "nitrates" * history of acute or chronic depression * history of heart problems such as angina, heart failure, irregular heartbeats or myocardial infarction * history of low blood pressure or high blood pressure that is not controlled * history of diabetes, liver problems, or kidney problems * a glomerular filtration rate of \<50ml/min. * history of retinitis pigmentosa or severe vision loss, including a condition called naion * history of stomach ulcers * history of hiv, multiple myeloma, or leukemia * history of peyronie's disease * history of spinal trauma or surgery to the brain or spinal cord * any contraindications to cialis use * currently participating in another clinical investigation

Keywords: prolonged, painful erection priapism sickle cell anemia
evaluation of central compartment dissection without thyroidectomy

Conditions: Thyroidectomy; Thyroid Cancer; Central Compartment Neck Dissction

Summary: in accordance with the current guidelines,papillary thyroid microcarcinoma such as turmo invasive nerve or trachea, requires total thyroidectomy for follow-up iodine-131 treatment.in the course of clinical work, if the patient can achieve r0 resection, most of the patients do not need iodine-131 treatment,therefore, there is no need to continue total thyroidectomy.to evaluate the practicable, thoroughness and clinical value of bilateral central compartment dissection while preserve contrary thyroid glands.

in accordance with the current guidelines,papillary thyroid microcarcinoma such as turmo invasive nerve or trachea, requires total thyroidectomy for follow-up iodine-131 treatment.in the course of clinical work, if the patient can achieve r0 resection, most of the patients do not need iodine-131 treatment,therefore, there is no need to continue total thyroidectomy.this study assesses new procedures by adjusting the sequence of procedures. complications and the thoroughness of the operation were evaluated, thus clinical value of bilateral central compartment dissection with preserve contrary thyroid glands were ananlyed.

Eligibility criteria:
inclusion criteria: tumor diameter less than 1cm the tumor is located in the lower part of the gland no lateral cervical lymph node metastases traditional open surgery exclusion criteria: select the endoscopic surgery or robotic surgery patients tumor invades the surrounding trachea and esophagus patients refused to participate
functional magnetic resonance imaging study of jaw-tapping movement on memory function

Conditions: Memory Disturbances

Summary: the purpose of this study is to examine the possibility of using jaw-tapping training as a self-exercise for developing memory and preventing dementia in elderly subjects with memory disturbances using functional magnetic resonance imaging (fmri).

right-handed female volunteers over the age of 50 years with subjective memory complaints are included in the study. volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders are excluded. the protocol was approved by the institutional review board of university-based hospital. after administering the seoul neuropsychological screening battery (snsb), mini-mental state examination (mmse) scores above 24 and clinical dementia rating scale (cdr) scores of 0 are considered subjective memory complaints (smc), and mmse scores above 23 and cdr scores of 0.5 are considered mci. all subjects undergo two mri scans. after the first mri, the subjects are trained to tap their jaws vertically at 1.6 hz at home twice a day for 30 seconds every day during four weeks.

Eligibility criteria:
inclusion criteria: * right-handed female volunteers over the age of 50 years with subjective memory complaints exclusion criteria: * volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders

Keywords: fmri jaw tapping memory disorder mild cognitive impairment mci working memory
three-dimensional virtual reality procedures in vestibular rehabilitation

Conditions: Vestibular Diseases; Virtual Rehabilitation

Summary: the aim of the present study will be to discover possible (i) improvements achievable in unilateral vestibular hypofunction patients using a self-assessed head-mounted device (hmd)-based gaming procedure when combined with a classical vestibular rehabilitation protocol (hmd group) as compared with a group undergoing only vestibular rehabilitation and (ii) hmd procedure-related side effects. main outcomes will be: otoneurological testing (vestibulo-ocular reflex gain study by means of vhit and posturography measures with particular attention on power spectra) and self-report and performance measures (dhi, dgi and abc). side effects of hmd implementation will be studied by means of simulator sickness questionnaires. moreover, second part of the study would collect patients' data one year after the end of the vestibular rehabilitation or its implementation with hmd.

due to the recent outbreak of virtual reality in the field of rehabilitation, the use of head-mounted devices has been proposed in addition to conventional vestibular rehabilitation therapy in unilateral vestibular hypofunction patients. this approach has been proved to be useful in maximizing vestibular rehabilitation outcomes, with minimum simulator-related side effects. virtual reality-based devices have been tested in vestibular rehabilitation by many clinicians, due to the possibility of achieving habituation, substitution and adaptation, the effectiveness in people presenting visual vertigo, and the positive effects on anxiety. thus, due to the undeniable relevance of testing outcomes of vestibular rehabilitation, and the promising results of head-mounted device-based home exercises in ameliorating its effects, the aim of this study will be to compare - in terms of short- (one week) and long-term (one year) effects - the subjective and objective indicators of vestibular function in a population of patients with unilateral vestibular hypofunction after completing conventional vestibular rehabilitation therapy with a randomized group who underwent a mixed-methods protocol including vestibular rehabilitation and head-mounted device treatment over the same period of time.

Eligibility criteria:
inclusion criteria: - right-handed patients affected by right chronic unilateral vestibular hypofunction, the diagnosis of which will be achieved with at least 25% reduced vestibular response at bithermal water caloric irrigations on one side when calculated by means of jongkees' formula after at least 3 months from the onset of symptoms. exclusion criteria: * negative anamnesis for malignancy, * negative anamnesis for head trauma, * negative anamnesis for neuropsychiatric disorders * negative anamnesis for metabolic diseases * negative anamnesis for cardiovascular diseases * negative anamnesis for endocrine diseases * treatment with drugs possibly impacting on auditory and visuo-vestibular functions * negative anamnesis for infectious diseases * negative anamnesis for otoneurological diseases
presence of circulating cluster of differentiation 4 positive 28 null t helper lymphocytes(cd4+cd28-) in patients with autoimmune hemolytic anemia.

Conditions: Autoimmune Hemolytic Anemia

Summary: 1. study the presence of circulating cd4+/cd28 null t lymphocytes in aiha either idiopathic or secondary. 2. role of cd4+/cd28 null t lymphocytes in monitoring response to therapy in aiha.

autoimmune hemolytic anemia (aiha) has always been considered the simplest and most scholastic example of antibody-mediated autoimmune disease.it has been identified as a greatly heterogeneous disease, due to several immunological mechanisms involved beyond antibodies, complement and antibody-dependent cell-mediated cytotoxicity (adcc). aihas may be idiopathic of unknown cause secondary associated with several conditions : (lymphoproliferative, autoimmune , infectious diseases, immunodeficiencies, solid tumors, transplants, and drugs).several subsets of t and b lymphocytes with highly specialized functions have been characterized. some lymphocytes promote inflammation, while others have anti-inflammatory roles, and an optimal balance between these two opposing sets of lymphocytes is critical for immune homeostasis. a pro-inflammatory subset of cd4+ t helper 1 (th1) lymphocytes known as cluster of differentiation 4 positive 28 negative t helper lymphocytes (cd4+cd28 null t cells) because they characteristically lack cd28 which is a co-stimulatory receptor critical for the activation and function of t cells.cd4+cd28 null t cells are rare in healthy individuals, but they increase in inflammatory and immune-mediated diseases. prevalence of cd4+cd28 null t cells is high in chronic inflammatory diseases, autoimmune diseases, immunodeficiency and specific infectious diseases.it remains controversial whether cd4+cd28null t cells are antigen specific and which are the precise antigens that trigger their expansion. it has been suggested that cd4+cd28null t lymphocytes are auto-reactive and that repeated stimulation by auto-antigens drives the expansion of this cell subset.expansion of the cd4+cd28 null t-cell subset in patients affected by autoimmune disorders has been linked to the severity of disease and an unfavourable prognosis.

Eligibility criteria:
inclusion criteria: * 1- newly diagnosed patients with aiha 2- patients with idiopathic or secondary aiha exclusion criteria: * 1-current steroid therapy 2- other concurrent chronic inflammatory conditions 3-recent blood transfusion 4- active hepatitis c virus
weight loss surgery in adolescents with extreme obesity

Conditions: Obesity; Extreme Obesity

Summary: the use of bariatric surgery in adolescents is controversial. on one side, bariatric surgery is the only effective treatment to achieve sustained weight loss in adults with extreme obesity. comorbidities are reversed and mortality is reduced. in adolescents, bariatric surgery is equally effective; however, due to the paucity of long-term data, the long-term effects and risks are unknown. thus, due to surgical risk and ethical implications, bariatric surgery is considered experimental in germany. nevertheless, case volumes are increasing. the aim of this study is to evaluate the benefits and risks of adolescent bariatric surgery in the context of a structured preparation and follow-up program. the study is a subproject of the study "medical and psychosocial implications of adolescent extreme obesity - acceptance and effects of structured care" (drks00004172). at 5 german university centers (ulm, datteln, berlin, essen, leipzig), youth who undergo bariatric surgery and are participants in the overall project will be enrolled in a structured preparation and follow-up program. the program is designed to improve adherence and compliance and will result in comprehensive follow-up data. in addition to the data gathered in the overall project, subjects participating in subproject 3 will undergo assessments pertinent to bariatric surgery, as proposed in the american teen-labs study (http://www.cincinnatichildrens.org/ research/divisions/t/teen-labs/default/). comparison will be made with bmi matched adolescents who participate in the overall project but do not undergo bariatric surgery. in november 2014 recruitment for the overall project was completed. however, patients interested in bariatric surgery will still be recruited until september 2016. there assessment will be the same as for patients recruited earlier. however, in an amendment in december 2014, the frequency of assessment via questionnaire was reduced from biannually to annually. in addition, a travel reimbursement of 30€ for each study visit was implemented.


Eligibility criteria:
inclusion criteria: * bmi ≥ 35 kg/m2 with severe comorbidity or bmi ≥ 40 kg/m2 with relevant comorbidity * completed longitudinal growth * stable social surroundings * exhaustion of conservative treatment * participation in the project "adolescents with extreme obesity" * adequate compliance and adherence exclusion criteria: * treatable causative condition * unstable medical, psychosocial or psychiatric comorbidity * alcohol or drug abuse * pregnancy * contraindication for bariatric surgery

Keywords: psychosocial, healthcare, co-morbidities, extremely obese adolescents
heated humidified oxygen compared to dry oxygen therapy in children with bronchiolitis

Conditions: Bronchiolitis; Hypoxemia

Summary: the purpose of this study is to compare heat and humidified oxygen with cold and dry oxygen in children with bronchiolitis. the hypotheses are that heating and humidifying inspired low flow supplemental oxygen will optimize mucociliary function thereby, 1) improve oxygenation, 2) decrease work of breathing, and 3) decrease length of hospital stay.

bronchiolitis is the leading cause of acute respiratory illness and hospitalization in infants and young children. the mainstay of treatment is supportive care, which includes frequent nasal suctioning, intravenous fluid hydration, and supplemental oxygen for hypoxemia. the airways normally heat and humidify inspired ambient air to core temperature amd 100% relative humidity at the carina. this environment, at core temperature, allows for optimal mucociliary clearance. supplemental oxygen delivered via wall source is cold and dry, and does not reach core temperature and 100% humidity until some point distal to the carina, past the main bronchi. this presses on the lower respiratory tract to assist in heat and moisture exchange and thus decrease ciliary function. this, in combination with bronchiolitis, can impair mucociliary clearance. specific aim 1: determine the effect of heated and humidified oxygen therapy on clinical improvement in children with bronchiolitis, based on respiratory distress assessment instrument (rdai) and respiratory rate (rr). specific aim 2: determine the effect of heated and humidified oxygen therapy on length of hospital stay and duration of supplemental oxygen requirement in children with bronchiolitis.

Eligibility criteria:
inclusion criteria: * ages ≤24 months of age * physician diagnosed bronchiolitis * admitted to pediatric floor * supplemental oxygen requirement, \<4 l/min, for hypoxemia, oxygen saturation \<92% in room air exclusion criteria: * prematurity, born \<37 weeks gestational age * admitted to pediatric intensive care unit for medical indication * requirement of heated, humidified high flow system * chronic lung disease (such as bronchopulmonary dysplasia, cystic fibrosis, primary ciliary dyskinesia, tracheostomy status, baseline oxygen requirement) * neuromuscular disorders * chromosomal defects * metabolic disorders * immunodeficiency * unrepaired cardiac abnormalities

Keywords: heat humidification oxygen
study to evaluate the efficacy and safety of cdk4/6 inhibitor shr6390 combined with pyrotinib in the treatment of her2-positive advanced breast cancer

Conditions: Metastatic Breast Cancer

Summary: the main purpose of this study was to observe the efficacy and safety of treatment with pyrotinib and cdk4/6 inhibitor shr6390 for her2-positive metastatic breast cancer.


Eligibility criteria:
inclusion criteria: * local recurrent or metastatic breast cancer suitable for chemotherapy, confirmed histologically. * her2-positive breast cancer(according to 2018 asco/cap her2 test guideline). * patients with her2-positive metastatic breast cancer who had received ≤ 1-line treatment in the past; * 18-70 years old. * ecog ps 0～1. * life expectancy is not less than 12 weeks. * at least one measurable lesion according to recist 1.1. * anc ≥ 2.0×109/l,plt ≥ 100×109/l,hb ≥ 90 g/l;tbil≤1.5uln；alt and ast≤3×uln（alt and ast≤5×uln if liver metastasis）;bun and cr≤1.5×uln * lvef ≥ 50% and qtc≤470 ms. exclusion criteria: * patients with symptomatic brain metastasis; * unable to swallow, chronic diarrhea and intestinal obstruction, there are many factors affecting drug use and absorption. * patient who received radiotherapy, chemotherapy, surgery (excluding local puncture) or molecular targeted therapy within 4 weeks before admission; those who received anti-tumor endocrine therapy after screening period * participated in other drug clinical trials within 4 weeks before admission * tyrosine kinase inhibitors targeting her2 (neratinib, lapatinib, pyrotinib, etc.) have been used or are being used in the past. * other malignant tumors, excluding cured cervical carcinoma in situ, skin basal cell carcinoma or skin squamous cell carcinoma, have been diagnosed in the past five years. * a history of immunodeficiency, including hiv positive, hcv,, or other acquired, congenital immunodeficiency disorders, or organ transplantation, is known. * has suffered from any heart disease * female patients during pregnancy and lactation, fertile women with positive baseline pregnancy tests or women of childbearing age who are unwilling to take effective contraceptive measures throughout the trial * according to the judgement of the researchers, there are concomitant diseases that seriously endanger the safety of patients or affect the completion of research (including, but not limited to, severe hypertension, severe diabetes, active infections, etc.). * moderate infection occurs within 4 weeks before the first administration (e.g. intravenous drip of antibiotics, antifungal or antiviral drugs according to clinical criteria), fever（\> 38.5 ℃） of unknown origin occurs during the screening period/before the first administration. * researchers believe that patients are not suitable for any other situation in this study.
treatment response to xiaflex for men with peyronie's disease

Conditions: Peyronie Disease

Summary: the purpose of this research study is to develop a database of patients with peyronie's disease who are treated at the university of miami. the collected data will help the researchers to better understand peyronie's disease and its response to therapy.


Eligibility criteria:
inclusion criteria: * age ≥18 years * able to provide informed consent * a stable relationship for ≥3 months * pd symptoms with evidence of stable disease as determined by the investigator * penile curvature deformity of \>30° to \<90° * has not had previous surgery for pd * has not had previous therapy with xiaflex for pd exclusion criteria: * ventral plaque * active phase pd * actively on anticoagulation during time frame of injections * aspirin 81mg will be eligible for therapy * hour glass deformity * previous allergic reaction to xiaflex * unwilling to participate * medically unfit for sexual intercourse as deemed by the principal investigator * patients scheduled to undergo an elective medical procedure during the investigation timeframe that will interfere with xiaflex injection cycles as deemed by the pi
the value of pelvic magnetic resonance imaging in detecting bone marrow infiltration of lymphoma

Conditions: Lymphoma

Summary: the diagnosis of lymphoma bone marrow infiltration is very important for the staging and treatment mode of lymphoma. traditional bone marrow cytology and pathology examinations are only performed locally, and missed diagnosis is possible. the study explore the value of multi-parameter pelvic magnetic resonance in detecting bone marrow infiltration with newly diagnosed lymphoma patients . this study also explore the consistency of pelvic magnetic resonance and pet/ct for detection of lymphoma bone marrow infiltration.


Eligibility criteria:
inclusion criteria: * lymphoma subtypes were diagnosed on the basis of tissue samples obtained by biopsy or surgery according to the criteria outlined in the current world health organization (who) classification of hematologic and lymphoid malignancies, by are reference pathologist. * patients who gave written informed consent were referred for mri. * stable physical medical conditions (patients conscious and comfortable, scheduled for an elective diagnostic imaging). exclusion criteria: • pregnancy, general contraindications to mri.