Kornimate/medical-research-clean huggingface dataset:
peer support group for adolescent and young adult (aya) allogeneic stem cell transplant recipients

Conditions: Cancer; Leukemia; Stem Cell Transplant

Summary: allogeneic haemopoietic stem cell transplant (allo-hsct) is a potentially curative option for patients with both malignant and non-malignant hematological disorders. there appears to be unique experiences that adolescents and young adults (aya) face when undergoing transplant. there is literature to suggest that peer support for young adults is associated with improvements in mental health including greater happiness, self-esteem and effective coping, as well as reductions in depression, loneliness and anxiety. our primary objective is to determine the feasibility and acceptability of an aya peer support program for patients undergoing allo-hsct. our secondary objective is to explore the impact of the aya peer support program on sense of support/connectivity, anxiety, and depression.


Eligibility criteria:
inclusion criteria: * 18-39 years of age * \>3 months post allo-hsct * any malignant /non-malignant indication for allo-hsct exclusion criteria: - non-english speaking

Keywords: peer support adolescents and young adults
subperiosteal implants constructed with digital technology

Conditions: Alveolar Bone Loss

Summary: atrophied jaw is a condition where there is insufficient bone quantity to place root form implants. several treatment plans are available for treating atrophied jaws, including subperiosteal implants. subperiosteal implants were introduced in the last century. poor clinical results led those implants to be progressively abandoned. recently, several authors suggested a revival of subperiosteal implants as an alternative to regenerative procedures.

an electronic and manual search was conducted in the pubmed, scopus, and google scholar databases. publications of case reports and series written in english without data restrictions that reported on subperiosteal implants management of patients with severely atrophied jaws in completely and partially edentulous population. the purpose of this systematic review of case reports and case series was to evaluate the spectrum of subperiosteal implants for severely atrophied jaws using digital technology.

Eligibility criteria:
inclusion criteria: * population with partial or fully edentulous arches, in particular cawood and howell class (iv-vi); exclusion criteria: * articles were excluded if complex reconstructive surgery including bone grafts, barrier membranes, jaw osteotomies, sinus lift, alveolar ridge distraction, and zygomatic implants was recommended for treatment
trial of xeloda and oxaliplatin (xelox) as neo-adjuvant chemotherapy followed by surgery in advanced gastric cancer patients with para-aortic lymph node metastasis

Conditions: Advanced Gastric Cancer

Summary: gastric cancer with para-aortic lymph node (pan) involvement is regarded as advanced disease, and only chemotherapy is recommended from the guidelines. in unresectable cases, neoadjuvant chemotherapy could prolong survival if conversion to resectability could be achieved.


Eligibility criteria:
inclusion criteria: 1. gastric or gastroesophageal adenocarcinoma proven histologically . 2. has para-aortic lymph node metastasis(pan was defined as nodes in the region between the upper margin of the celiac artery and the upper border of the inferior mesenteric artery (stations no. 16a2/16b1)) 3. eastern cooperative oncology group performance status of 0 to 1. 4. life expectancy ≥12 weeks. 5. adequate hematological function: neutrophil count ≥ 1.5 × 109/l, platelets ≥ 100 × 109/l and hemoglobin ≥9 g/dl (may be transfused to maintain or exceed this level). adequate liver function: total bilirubin ≤ 1.5 × upper limit of normal (uln); ast (sgot) and alt (sgpt) \< 2.5 × uln , alp ≤ 2.5 × upper limit of normal (uln); alb ≥30g/l。 adequate renal function: serum creatinine ≤ 1.25 x uln, and creatinine clearance ≥ 60 ml/min. 6. female subjects should not be pregnant or breast-feeding. 7. no serious concomitant disease that will threaten the survival of patients to less than 5 years. exclusion criteria: 1. serious concomitant disorders that would compromise the safety of the patient or compromise the patient's ability to complete the study, at the discretion of the investigator. 2. history of another malignancy in the last 5 years with the exception of the following: any previous palliative, adjuvant or neoadjuvant chemotherapy and/or radiotherapy. prior treatment for locally advanced or metastatic gastric cancer. 3. any other metastatic disease will render patient ineligible according to ajcc staging manual(such as liver，lung，etc）. 4. active infection that in the opinion of the investigator would compromise the patient's ability to tolerate therapy. 5. poorly controlled diabetes mellitus with fasting blood sugar \> 18 mm. second primary malignancy that is clinically detectable at the time of consideration for study enrollment. 6. unstable, persistent cardiac disease despite medicinal treatment, myocardial infarction within 6 months before the start of the trial 7. previous surgery on primary tumour; prior palliative surgery (open and closure, passage operation) 8. any other type of tumour (e.g. leiomyosarcoma, lymphoma) or a secondary malignancy, excepting basal cell skin carcinoma or basal cell carcinoma in situ of the cervix which have already been successfully treated -

Keywords: neo-adjuvant chemotherapy advanced gastric cancer patients para-aortic lymph node metastasis
evaluation of thriving, substance use, mental health, and repeat injury among participants in the thrive program

Conditions: Violence; Assault

Summary: the goal of this observational study is to determine the impact of a hospital-based violence intervention program on a person's capacity to thrive and recurrent intentional injury. the aims of this study are: 1. to evaluate the impact of the hvip on building personal capacity of youth who have experienced non-fatal violent injuries to thrive using: * established measure changes in positive psychology and clinical metrics * a qualitative interview using thematic content analysis 2. plot the methodology proposed to measure the impact of thrive on subsequent injuries using administrative data sources participants will complete surveys, participate in a semi-structured interview, and have their rate of recurrent intentional injury tracked over time. researchers will compare the rates of intentional reinjury between participants in the thrive program and those who present at other hospitals with similar injuries to see if there is a difference in the rate of recurrent intentional injury a 1, 5, and 10 years.


Eligibility criteria:
inclusion criteria: * ages 14-29 * presentation with an injury due to violence (defined as a gun shot wound, stab wound, blunt or bodily force, inflicted by someone else) * participant in the thrive program exclusion criteria: * unable to consent due to language barrier or brain injury * sexual assault * child abuse * self-inflicted injury * residence \>1 hour from toronto city limits
a study of ly3454738 in healthy participants and participants with atopic dermatitis

Conditions: Dermatitis, Atopic

Summary: the main purpose of this study is to investigate the safety, tolerability, and efficacy of the study drug known as ly3454738 in healthy participants and participants with atopic dermatitis. the study has three parts. each participant will enroll in one part. the study will last 12 to 24 weeks, depending on part.


Eligibility criteria:
inclusion criteria: * all: must have a body mass index of 18.0 to 32.0 kilograms per square meter (kg/m²), inclusive, for parts a and b, and 18.0 to 45.0 kg/m², inclusive, for part c and a minimum body weight of 50 kilograms * for part a and b only, regarding the inclusion of healthy japanese participants: minimum age is 20 years and the participant's biological parents and all of the participant's biological grandparents must be of exclusive japanese descent and must have been born in japan * ad: * must have a diagnosis of ad for at least 12 months with either poor response to topical treatments or inability to use topical treatments * must agree to use moisturizer daily throughout the treatment period exclusion criteria: * all: must not have previously completed a clinical trial with a molecule targeting interleukin-33 (il-33) or its receptor * ad: * must not have received certain topical medications for ad within 2 weeks prior to randomization * must not have received certain oral medications for ad or received phototherapy within 4 weeks prior to randomization * must not have received any antibody-based biologic agents (marketed or investigational) within 5 half lives (t1/2) of the drug prior to randomization * must not have received intravenous, intramuscular, or intra-articular steroids in the past 6 weeks prior to randomization
feasibility of treatment of cancer involving the liver with high dose radiation

Conditions: Liver Neoplasms; Neoplasm Metastasis

Summary: a study is being conducted by the university of rochester cancer center (urcc) in which patients with liver cancer will be treated with high dose conformal radiation therapy. this type of radiation uses new techniques which aim the radiation to the sites of disease allowing the tumor to receive a high dose and the surrounding normal liver tissue to receive a low enough dose that the normal tissue should remain free from injury. the purpose of the study is to determine if the conformal radiation therapy is safe, tolerable and effective in treating liver cancer and to determine the side effects caused by this treatment. a second objective is to determine if the levels of a special type of protein (called cytokines) found in the blood are related to this treatment.


Eligibility criteria:
inclusion criteria: * patients must have new hepatic lesions suggestive of metastasis, or otherwise biopsy proven disease if there is no previously negative scan. * patients with chemotherapy responsive or resistant disease are acceptable. primary hepatobiliary tumors are also acceptable. in each case, the patient must be deemed unresectable by a hepatic surgeon. * patients with multiple hepatic lesions may be included if they meet the volumetric criteria for dose specification. likewise, patients with metastases to organs other than the liver, or patients with residual primary disease may be included if it is judged that longevity will be determined by the hepatic disease. * kps ≥70 * age ≥ 18 years * bilirubin \ 80,000/mm3 * chemotherapy treatment before or after radiation will be allowed * informed consent must be obtained., patient must be judged unresectable by a hepatic surgeon, or must have refused surgery * patient must be able to tolerate radiation treatment as judged by the principal investigator or co-pi. * previous liver resection is allowed * active disease outside the liver is allowed. * liver lesion should be visible on ct or mri. exclusion criteria: * no active hepatitis or radiographic evidence of diffuse macro-nodular cirrhosis. patients with lesser degrees of cirrhosis, not associated with portal hypertension or hepatic failure, are eligible but radiation schedule and total dose will be appropriately modified. * women who are pregnant
efficacy of inhalation of essential oil on the reduction of inhalants craving

Conditions: Inhalants Craving

Summary: inhalants, which are neurotoxic central nervous system (cns) suppressants, are frequently abused by young adults. unlike other cns depressants, including alcohol and opiates, no treatment is currently approved for inhalants dependence. in this report, a novel approach of substitution treatment for inhalants addiction was explored in a double-blinded, randomized, controlled crossover design to examine the effects of inhalation of essential oil (eo) and perfume (pf) on the reduction of cue-induced craving for inhalants in a cohort of thirty-four thai males with inhalants dependence. the craving response was measured by the modified version of penn alcohol craving score for inhalants (pacs-inhalants)


Eligibility criteria:
inclusion criteria: * participants with ability to smell if they could correctly identify 3 out of 5 odors, namely fish sauce, lemon, onion, basil, and jasmine. * individuals with inducible picture-cues inhalant craving based on a 50% increase in craving score from baseline. exclusion criteria: * individuals with a history of major psychiatric disorders, including psychotic and mood disorders * individuals with illicit substance dependence other than inhalants * individuals with allergic reactions to essential oil or perfume.
efficacy and safety study of infliximab (remicade) to treat early ankylosing spondylitis

Conditions: Spondylitis

Summary: this is a prospective open-label study to evaluated the efficacy and safety of infliximab(remicade) in treating of patients with early ankylosing spondylitis (as). infliximab was injected intra-venous on baseline, 2nd week, 6th week, 12th week and 24th week, with dosing of 5mg/kg. the major outcome index is asas20, and minor outcome indexes include asas50 and asas70, basdai20,basdai50 and basdai70. and mri of sacroiliac joint is not necessary. the adverse events at any time were recorded.


Eligibility criteria:
inclusion criteria: 1. 16 to 65 years old, having signed the informed consent; 2. fulfill the essg criteria for diagnosis of spa; not fulfill the 1984 modified newyork criteria for as; 3. have inflammatory back pain defined by calin criteria; 4. disease duration range from 6 months to 2 years; 5. basdai score more than 4; 6. mri score of sacroiliac joint more than 4; 7. lab examination: hemoglobin more than 90 gram/liter. aspartate aminotransferase and alanine aminotransferase less than 2 fold of upper level of normal range. creatine less than upper level of normal range. exclusion criteria: 1. history of psoriasis or inflammatory bowel disease. 2. intra-articular injection of cortisone within 3 months. 3. patients were taking cortisone, sasp or mtx, unless the dose has been stable for at least 3 months. 4. active iritis. 5. history of heart failure, multiple sclerosis, copd, lymphoma or other tumor, tuberculosis. 6. female of pregnancy or breast feeding. 7. history of mental disease and poor compliance. 8. history of drug abuse or alcoholism.

Keywords: spondylitis, ankylosing infliximab antibodies, monoclonal
dixon mri imaging histology for predicting postoperative infection in posterior lumbar fusion for myasthenia gravis

Conditions: Lumbar Vertebrae; Surgical Site Infection; Radiomics

Summary: sarcopenia is an age-related condition that manifests itself as a persistent decrease in muscle mass and function, which may lead to decreased physical function, increased risk of disease, and reduced quality of life. in surgical patients, sarcopenia has been shown to be associated with increased postoperative complications, prolonged hospitalization, and decreased survival. in patients undergoing lumbar fusion, the presence of sarcopenia may increase the risk of postoperative infection.lumbar fusion is a common procedure to treat lumbar spine disorders such as lumbar disc herniation, lumbar spondylolisthesis, or lumbar spinal stenosis. however, this procedure is associated with a high rate of complications, especially postoperative infections, which can lead to reoperation, prolonged hospitalization, and even affect patient survival. in recent years, more and more studies have found a significant association between sarcopenia and postoperative infections after lumbar fusion surgery.imagingomics belongs to a branch of machine learning, which is the process of acquiring images from various imaging devices such as ct, mri and ultrasound, outlining the region of interest through image segmentation, extracting the features of the image within the region of interest, downscaling the features, and finally building an imagingomics model. mri imagingomics, utilizing its rich data information, has shown great potential for application in several medical fields. among them, the accuracy of dixon mri imaging histology in muscle mass and texture assessment makes it particularly important in predicting postoperative infections.based on this, it is reasonable to believe that dixon mri imaging histology can be a powerful tool to help us predict a patient's risk of postoperative infection.


Eligibility criteria:
inclusion criteria: * male and female patients over 18 years of age. * inclusion of patients with sarcopenia is subject to the definition and diagnostic criteria of the european consensus on definition and diagnosis of sarcopenia. * the patient underwent posterior lumbar fusion and had a dixon mri scan within 2 weeks prior to surgery. * patients were able to understand the purpose and procedures of the study and were willing to sign an informed consent form. * the patient's clinical consultation and follow-up information was complete. exclusion criteria: * the patient has contraindications to mri, such as implanted metal devices (e.g., pacemakers) or severe claustrophobia. * patients with serious other medical conditions, such as heart disease, kidney disease or liver disease, which may affect their post-operative recovery. * patients have known immune system disorders or are on immunosuppressive therapy, which may affect their risk of infection. * the patient has had other spinal surgery within the last 6 months.
study of a clostridium difficile toxoid vaccine (acam-cdiff™) in subjects with clostridium difficile infection

Conditions: Diarrhea; Clostridium Difficile Infection

Summary: primary objective: to compare the event rate of cdi in groups assigned to acam-cdiff™ vaccine versus placebo in the 9 week period after the third dose of the study vaccine in subjects with first episode of cdi receiving antibiotics standard of care. secondary objective: to evaluate the safety of all dose groups of acam-cdiff™ vaccine versus placebo in subjects with first episode of cdi receiving antibiotics standard of care.

this study is designed primarily to obtain information on the preliminary efficacy, safety and immunogenicity of acam-cdiff™ vaccine, as compared to placebo in subjects who are experiencing their first event of cdi and are being treated with the antibiotic standard of care. this study will be conducted in the united states and united kingdom. adult subjects with limited chronic disease, who are currently receiving treatment for their first episode of cdi will be enrolled in this trial. subjects will be required to be able to take oral antibiotics.

Eligibility criteria:
inclusion criteria: 1. adult subjects, 18 - 85 years old, who understand the risks and benefits of participation and have provided written informed consent for the study. 2. subjects who are experiencing a first event of cdi diagnosed within the last 10 days. 3. subjects who are medically stable. 4. subjects who are willing and able to comply with the study procedures and visit schedules outlined. exclusion criteria: 1. subjects who are currently on treatment for a recurrence of cdi. 2. subjects who are currently or have recently been treated with immunoglobulin therapy. 3. pregnant or breast feeding females. 4. concurrent, acutely life-threatening diseases.

Keywords: diarrhea clostridium difficile infection clostridium difficile toxoid
assessment of child psychological attributes for prediction of child behavior at first dental visit

Conditions: Psychological Disorders

Summary: one of the most prevalent chronic diseases worldwide is mental disorder, including social, emotional, and behavioral problems, and it is the fifth main cause of global disability . in egypt, it is estimated that 20.6% of children aged from 6-12 years had behavioral problems behavioral and emotional problems may affect deeply child's quality of life, such as impairment of school life (high absence), they may cause nutritional imbalance and even suicidal thoughts. therefore, both the dentist and the family should be adequately prepared to deal with those children who come seeking dental treatment. recently, studies proved the association between the psychological characteristics and the behavior of children in dental setting. there was a study that showed that there is a relation between psychological functioning of the child, dental anxiety and his/her behaviour during dental appointment. furthermore, it was found that there is a correlation between the temperamental difficulties or emotional problems of the child and the non-cooperative behavior during the process of injection of the local anesethia. these studies ensures the importance of understanding the effect of mental disorders on the behavior of children during dental treatment, as it would help the professionals to properly plan the clinic appointments without any delay or cancellation of the appointment and allows him to render effective and efficient dental treatment.

this study aims to acknowledge the different psychological attributes among children seeking dental treatment at young age and to assess the association between child psychological attributes and his/her behavior in dental clinic.

Eligibility criteria:
inclusion criteria: * children: school aged children (4 to 7) years old * teeth: carious teeth requiring a simple dental treatment (cavity preparation with restoration) exclusion criteria: * children: * medically compromised children. * children with previous dental history. * refusal of participation.

Keywords: psychological attributes child mental disorders strength and difficulties questionnaire child behavior
dissecting the biology of early-onset colorectal cancer

Conditions: Colon Cancer

Summary: contrarily to late-onset (lo) colorectal cancer (crc), early-onset (eo) crc incidence is increasingly growing. several factors, such as obesity, chronic inflammation, and intestinal dysbiosis, can increase the general risk of crc. however, little is known about the biology of eo-crc. to evaluate whether such selective rise in the incidence of eo-crc patients mirrors a distinct transcriptomic profile, the investigators will first dissect eo-crc's transcriptomic landscape. then, the investigators will investigate the colorectal cancer stem cell (csc) compartment by in vitro functional assays and rna-seq analysis. because our preliminary data indicate an increased aggressiveness of the tumor microenvironment (tme) in eo-crc,the investigators propose to investigate the csc niche and the interaction with the tme to dissect the molecular and cellular pathways occurring in eo-crc. a cohort of 30 eo-crc patients (\<50 years old) will be enrolled and fully characterized. about 10 eo-crc-derived cscs in the form of organoids and spheroids will be generated. since the relevant differences between cr-cscs isolated from eo-crc vs lo-crc patients are still unknown, the investigators will gain information about their specific features such as clonogenic activity, tumorigenic/invasive capacity, and about differences in the mechanisms regulating their cross-talk with tme components.


Eligibility criteria:
inclusion criteria: * age \> 18 and \< 50 years ; * written informed consent exclusion criteria: * non-availability of informed consent.