Kornimate/medical-research-clean huggingface dataset:
implementation of a collaborative care model to manage depression among adolescents and young adults in hiv services in thailand

Conditions: Depression; HIV

Summary: this study aims to investigate the acceptability and feasibility of the implementation of a collaborative care model (ccm) to screen and treat depression. this model will includes cognitive behavioral therapy (cbt) and useof a task-shifting model to address depression among adolescents and young adults (aya) who are seeking hiv treatment and prevention services at a hospital in bangkok, thailand. analyses will be guided by the consolidated framework for implementation research (cfir), which will include the identification of facilitators and barriers to implementation of this ccm. in the last 3 years, 10-20% of aya patients at king chulalongkorn memorial hospital (kcmh) who seek hiv treatment or prevention services suffer from mental health disorders. as a result, ccm integration for depression screening and treatment was implemented at the 'cu buddy clinic' kcmh with the ultimate goal of increasing access to and engagement in mental healthcare with a goal to improve the overall quality of life for thai aya. this project will inform a future implementation science study that will focus on how the optimization of integrated mental healthcare into routine aya hiv treatment and prevention services can impact health outcomes for patients, including art adherence and long-term viral suppression (aya living with hiv) and hiv acquisition risk behaviors and prep adherence (aya at risk for hiv).


Eligibility criteria:
aya patients at the cu buddy clinic (for both quantitative and qualitative study) inclusion criteria * aged 15-24 years of age * starting or currently receiving hiv treatment and prevention services, which includes any individual or combination receipt of the following services: art, prep, hiv testing, receipt of condoms, hiv risk counselling * thai nationality exclusion criteria • individuals with a history of, or are currently receiving, mental healthcare at the cu psychiatric clinic or elsewhere service providers at cu buddy clinic inclusion criteria • current staff providing care at the cu buddy clinic with any active patient interface, such as physicians, nurses, peer navigators, psychologists and psychiatrists exclusion criteria * staff with less than 3 months duration of service at the cu buddy clinic * staff who are not affiliated with the cu buddy clinic
autologous tumor-infiltrating lymphocyte (gte-001 injection ) for treatment of patients with advanced lung adenocarcinoma

Conditions: Advanced Lung Adenocarcinoma；Adult

Summary: this study is a multiple centers, open design aimed at evaluating the safety,efficacy and production feasibility of autologous tumor-infiltrating lymphocyte (gte-001 injection ) for treatment of patients with advanced lung adenocarcinoma,and evaluate potential biomarkers related to gte-001 activity.


Eligibility criteria:
inclusion criteria: * 1. voluntarily join the study, signed informed consent form， willing and able to comply with the study protocol; * 2. age ≥18 years old; * 3. advanced lung adenocarcinoma that progresses after recurrence or first-line chemotherapy； * 4. eastern cooperative oncology group (ecog) performance status score of 0 or 1; * 5. expected survival time of ≥ 3 months; * 6. good function of vital organs; * 7. at least one measurable target lesion that meets the definition of recist v1.1 after tumor sampling. exclusion criteria: * 1.subject has previously received an allogeneic stem cell transplant or organ allograft,subject has previously received engineered cell therapy,prior folr1 directed therapy is not allowed unless it had been with an approved agent in the indication; * 2.subject has undergone surgery or received radiotherapy, immunotherapy, targeted therapy agents, anticancer vaccines, systemic steroids, or chemotherapy within 2 weeks of enrolment. targeted agents, such as tyrosine kinase inhibitors, may be continued until 5 half-lives before enrolment; * 3.pregnant or lactating women; or women who are pregnant, breastfeeding, or planning to become pregnant within 12 months after cell infusion; * 4.history of central nervous system (cns) disorder,history of autoimmune disease,history of primary immunodeficiency;
neo-penotran forte vaginal suppository for vaginal trichomoniasis

Conditions: Trichomonas Vaginitis

Summary: the investigators are trying a combination vaginal product of higher dose metronidazole combined with miconazole to see if it is effective in treating vaginal trichomonas.


Eligibility criteria:
inclusion criteria: * presence of trichomonas exclusion criteria: * pregnant or nursing * known immunodeficiency * allergy to study drugs * concurrent yeast infection * history of seizures or peripheral neuropathy * unwillingness to abstain from alcohol during treatment period and for 48 hrs after concurrent lithium * anticoagulation therapy, and abuse * patient expected to have menses within 8 days of enrollment

Keywords: trichomonas
cardioneuroablation for variant angina

Conditions: Variant Angina

Summary: variant angina, also known as vasospastic angina, is a form of chest pain caused by temporary spasms of the coronary arteries, which reduce blood flow to the heart. these spasms often occur at rest and may lead to serious complications, including life-threatening heart rhythm problems and sudden cardiac death. while most patients improve with medications such as calcium channel blockers and nitrates, some continue to have symptoms despite treatment. in addition, some patients are unable or unwilling to take medications regularly, which further limits effective management. these cases are referred to as medication-refractory or drug-intolerant variant angina. the autonomic nervous system, which controls involuntary functions like heart rate and blood vessel tone, is believed to play an important role in the development of coronary artery spasms. recent research suggests that imbalances in autonomic activity, particularly excessive parasympathetic signals, may trigger these spasms. cardioneuroablation (cna) is a minimally invasive procedure that uses a catheter to target specific nerve clusters called cardiac ganglionated plexi, located on the surface of the heart. these plexi are important centers of autonomic control and are mostly made up of parasympathetic nerve cells. originally developed to treat conditions such as fainting spells and certain types of abnormal heart rhythms, cna works by selectively reducing abnormal parasympathetic activity in the heart. this study is designed to explore whether cna can help relieve chest pain and reduce coronary spasms in patients with variant angina who do not respond to medications or cannot take them consistently. the study will evaluate the safety, practicality, and potential benefits of this approach as a new treatment option for a difficult-to-manage heart condition.


Eligibility criteria:
inclusion criteria: * age between 18 and 80 years; * variant angina; * positive ergonovine provocation test; * refractory to antispasmodic drug therapy, or inability to achieve adequate symptom control due to drug intolerance, poor adherence, or unwillingness to take medications regularly. exclusion criteria: * cardiogenic shock; * chronic heart failure; * life expectancy less than 12 months; * current participation in another clinical study without completing the primary endpoint visit; inability to provide informed consent; * women of childbearing potential without effective contraception or who are breastfeeding; * coronary artery stenosis ≥50% or ffr ≤0.80; * sick sinus syndrome or high-degree av block without pacemaker; * systolic blood pressure \<90mmhg or heart rate \<50 bpm; * allergy to diltiazem, nitrates, or nitroglycerin.
building collaborations to address drug problems in the united states and china

Conditions: Chronic Pain

Summary: the purpose of this study is to evaluate the impact of a cognitive behavioral therapy (cbt) intervention on the distribution and variability of pain level before and after intervention receipt among people with co-occurring chronic pain and substance use disorders (suds) over a three-month follow-up period.

the project is an open trial of the cbt intervention for 20 adults receiving detoxification treatment with comorbid pain. participants will be screened for pain and other conditions by completing a self-report survey questionnaire. eligible participants will be asked to complete a baseline assessment. a trained research therapist will conduct individual therapy with participants twice a week for 2-4 weeks. participants will be re-assessed at 1- and 3-month post-intervention follow-ups to track changes in their pain, functioning, and substance use.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * currently receiving detoxification treatment * report pain of at least moderate or greater intensity over the three months prior to baseline assessment as indicated by an average score of four or greater on the numeric rating scale (nrs) * have access to a phone for confidential personal therapy after the completion of detoxification treatment. for individuals who enter the residential treatment at the facility following the detoxification treatment, a research therapist will meet with them in person at a private office at the facility during their stay due to program's restriction on phone usage. exclusion criteria: * inability to speak and understand english * inability to give informed, voluntary, written consent

Keywords: cognitive behavioral therapy
fermented dairy products and the metabolic syndrome

Conditions: Overweight or Obesity; Metabolic Syndrome

Summary: the study will be conducted as a randomized controlled trial with four parallel arms including four dairy products. we will investigate the health effects of including yogurt in the diet through a 16-weeks intervention period among 100 volunteering males with symptoms of the metabolic syndrome. the study has a total duration of 20 weeks as a wash out period of four weeks will be initiated prior to the intervention.


Eligibility criteria:
inclusion criteria: * male * age between 30-70 years * bmi of 28-45 kg/m2 * abdominal obesity (defined as waist circumference \>102 cm) * provided voluntary written informed consent exclusion criteria: * body weight changes +/- 5% in the past three months * any diet, allergy or intolerance which results in not being able to follow the study protocol * contraindications related to mri (pacemaker, stent, magnitic metal in the body, claustrophobia, physiological diseases or a body weight \>160 kg) * history or diagnosis of diabetes * history or diagnosis of heart, liver, gastrointestinal or kidney disease * history or diagnosis of illness related to energy balance * history or diagnosis of eating disorders * simultaneous blood donation for other purpose than this study (and one month before initiating the study) * simultaneous participation in other clinical intervention studies * any other condition that judged by the investgator may interfere with the adherence to the study protocol

Keywords: dairy liver fat glucose metabolism
an evaluation of the effect of a surface acoustic wave patch device on the symptons of trigeminal neuralgia

Conditions: Trigeminal Neuralgia

Summary: this is a double blinded randomized control trial of a surface acoustic wave patch device for the treatment of trigeminal neuralgia. this will be a crossover study for the group that receives the sham device. subjects will be monitored for subjective criteria of pain and quality of life, as well as objective measurement of analgesic usage.

this study is a double blinded randomized control trial of a surface acoustic wave patch device for the treatment of trigeminal neuralgia. all subjects will be enrolled for a 14 day lead up period, where baseline measures of pain, quality of life and analgesic use will be recorded. during the first month of the study subjects will be randomized into a sham or active device group. both groups will be assessed every two weeks for pain, quality of life and analgesic use. after 4 weeks, those subjects in the sham group will be crossed over into the active group. both groups will continue to be assessed biweekly through months 2 and 3. after 3 months of treatment a final assessment will be conducted and the results evaluated.

Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the study. * male or female, aged 18 years or above. * diagnosed with trigeminal neuralgia refractory to medical treatment (modified bni v). exclusion criteria: * male or female, under the age of 18. active illicit drug use pregnancy. psychiatric illness which may prevent the patient from participation in the study. anesthesia dolorosa with pain greater than or equal to 3/10 dental implants. other known pathology of the trigeminal nerve including iatrogenic anesthesia dolorosa. cancer and bone metastases.
automated cervical cancer screening using a smartphone-based artificial intelligence classifier

Conditions: Cervical Cancer; HPV

Summary: cervical cancer remains a major public health challenge in low- and middle-income countries (lmics) due to financial and logistical issues. the world health organization (who) recommendation for cervical cancer screening in lmics includes human papillomavirus (hpv) testing as primary screening followed by visual inspection with acetic acid (via) and treatment. however, via is a subjective procedure dependent on the healthcare provider's experience. therefore, an objective approach based on quantitative diagnostic algorithms is desirable to improve performance of via. with this objective and in a collaboration between the gynecology and obstetrics department of the geneva university hospital (hug) and the swiss institute of technology (epfl), our group started the development of an automated smartphone-based image classification device called avc (for automatic via classifier). two-minute videos of the cervix are recorded during via and classified using an artificial neural network (ann) and image processing techniques to differentiate precancer and cancer from non-neoplastic cervical tissue. the result is displayed on the smartphone screen with a delimitation map of the lesions when appropriate. the key feature used for classification is the dynamic of cervical acetowhitening during the 120 second following the application of acetic acid. precancerous and cancerous cells whiten more rapidly than non-cancerous ones and their whiteness persists stronger overtime. our aim is to assess the diagnostic performance of the avc and to compare it with the performance of current triage tests (via and cytology). histopathological examination will serve as reference standard. participants' and providers' acceptability will also be considered as part of the study. the study will be nested in an ongoing cervical cancer screening program called "3t-approach" (for test, triage and treat) which includes hpv self-sampling for women aged 30 to 49 years, followed by via triage and treatment if needed. the avc will be evaluated in this context. the study's risk category is a according to swiss ethical guidelines. this decision is based on the fact that the planned measures for sampling biological material or collecting personal data entail only minimal risks and burdens.


Eligibility criteria:
inclusion criteria: * free and informed consent to take part in the study on a voluntary basis exclusion criteria: * no initiation of sexual intercourse * pregnancy at the screening consultation * any condition altering the cervix visualization at the screening consultation (e.g. heavy vaginal bleeding) * history of anogenital cancer or known anogenital cancer at the screening consultation * previous hysterectomy * not sufficiently healthy to participate in the study

Keywords: cervical cancer screening hpv-related cervical precancer and cancer artificial intelligence image processing automated via classifier
silver diamine fluoride/ potassium iodide in indirect pulp capping of young permanent molars

Conditions: Tertiary Dentine; Indirect Pulp Capping

Summary: the aim of this study is to evaluate and compare the clinical effectiveness of 38% silver diamine fluoride with and without potassium iodide with that of resin modified glass ionomer cement in indirect pulp capping of young permanent molars.

a sample of children with an age range of 6-9 years, having a first permanent molar erupted with deep occlusal carious lesion, will be selected from the outpatient clinic of pediatric dentistry and public health department, faculty of dentistry, alexandria university after securing necessary consents. all selected 108 first permanent molars will be randomly equally allocated into three groups according to capping material used. group i (n=36) sdf/ ki and group ii (n=36) sdf and group iii (n=36) glass ionomer cement. indirect pulp capping treatment procedure will be performed with identical protocols except for the capping material to be used and its application will be according to manufacturer's instructions. glass ionomer cement will be used as a base and resin-based composite restoration will be used in the three groups.

Eligibility criteria:
inclusion criteria: for children: 1. children who are generally healthy. 2. children having a deep dentin carious lesion in a permanent first molar (upper or lower). 3. parents signed informed consent. for first permanent molars: 1. cavitated class i carious lesions with opaque or discolored enamel exposing the dentin beneath corresponding to icdas ii score 5 and 6 (visible dentin). (ekstrand kr, martignon s, ricketts d, qvist v. 2007) 2. teeth having lesions that are considered active according to icdas ii activity criteria for primary coronal caries. (ekstrand kr, martignon s, ricketts d, qvist v. 2007; dikmen b. 2015) 3. immature with open apex as revealed by periapical x-ray. exclusion criteria: for children: 1. any allergy reported by the parents. (crystal yo, marghalani aa, ureles sd, wright jt, sulyanto r, divaris k, et al. 2017) 2. children unable to return for recall visits. for first permanent molars: 1. any clinical signs of irreversible pulpitis (spontaneous pain, pain on percussion, abscess, sinus. 2. any radiographic sign of irreversible pulp pathologies or necrosis periapical radiolucency, internal or external root resorption). 3. teeth with inactive lesions. (ekstrand kr, martignon s, ricketts d, qvist v. 2007; dikmen b. 2015)

Keywords: silver diamine fluoride/ potassium iodide glass ionomer cement
working memory and physical exercise training in patients with mild cognitive impairment

Conditions: Mild Cognitive Impairment

Summary: the prevalence of dementia will double in the next three decades in the u.s.; effective treatment or prevention for dementia is urgently needed. the current exploratory project aims to evaluate and understand how the brain and cognition may improve after a 12-week intervention that combines brain training and aerobic exercise training to improve brain function, both in those with mild cognitive impairment (some with possible prodromal alzheimer's disease) and with healthy aging. findings from this pilot project will guide and refine the development of a future larger clinical trial that aligns with the goals of the national alzheimer's plan of action (napa), especially regarding "prevent and effectively treat alzheimer's disease (ad) by 2025.


Eligibility criteria:
inclusion criteria: * adult men and women of all races and ethnicities who are 50-80 years of age will be eligible. * only sedentary adults will be eligible (engaging in structured activity for exercise \<3x/week) for progressive aerobic exercise or combined training * ability to use, and accessibility to, an ipad or computer is required for the adaptive cognitive training and combined training. * fluent in english. * the diagnosis of mci will first be confirmed at the screening evaluation using the clinical dementia rating (cdr) scale and the montreal cognitive assessment (moca). we will also evaluate their adl using instrumental activities of daily living (iadl) to ensure they have preserved independence in functional abilities despite the cognitive deficits. the primary caregivers will be interviewed (either in person or by phone) for the participants' iadl to corroborate the independent functional status. exclusion criteria: * does not have access to a computer or internet to perform the cogmed® training and is unwilling to come to the lab for the training. * unable to undergo an mri investigation based on claustrophobia or metal foreign bodies. * symptomatic heart disease, coronary artery disease, congestive heart failure, uncontrolled hypertension, uncontrolled diabetes (hba1c\>10%), significant cardiovascular disorders (on ekg and graded exercise test) that would prevent the participant from the exercise training; neurologic, musculoskeletal, or other condition that limits the subject's ability to complete study physical assessments. * estimated verbal intelligence quotient (iq) below 70 (based on the wechsler test of adult reading) which would invalidate the informed consent process for the study. * self-reported moderate to severe substance use disorder(s) (e.g., self-reported intake \>3 oz liquor, or three 4 oz glasses of wine, or three 12 oz cans of beer per day or illicit drug use). * severe chronic or acute medical or other (non-mci) neuropsychiatric conditions that might confound the cognitive or brain imaging measures (e.g., liver function tests \>2.5 normal range or evidence for renal failure). * body mass index \>40 kg/m2.
effects of berry nectars sweetened with inverted sugar on post-meal blood sugar

Conditions: Hyperglycemia, Postprandial

Summary: berries have been shown to improve postprandial glucose and insulin responses to sucrose. during processing and storage of berry products, sucrose is inverted to glucose and fructose. the effects of berries on the glycemic response induced by inverted sugar are not known. the purpose of this study is to determine whether berries are effective in lowering the postprandial glucose and insulin responses induced by inverted sugar.


Eligibility criteria:
inclusion criteria: * bmi 20-28 kg/m2 * normal fasting plasma glucose exclusion criteria: * smoking * diabetes or other chronic disease * antibiotic medication within the past 3 months * blood donation within the past month

Keywords: berries blackcurrant (ribes nigrum) lingonberry (vaccinium vitis-idaea) sucrose inverted sugar postprandial glucose response postprandial insulin response