Kornimate/medical-research-clean huggingface dataset:
search of protein biomarkers in order to achieve a molecular classification of gliomas

Conditions: Glioblastoma

Summary: the aim is to classify high grade glioma by matrix-assisted laser desorption/ionization mass spectrometry imaging (maldi msi). in order to provide more specific informations for the diagnosis and the prognosis of high grade glioma.


Eligibility criteria:
main inclusion criteria: * patients with grade iii or iv glioma newly diagnosed with histological evidence * surgical indication * tumor tissue available at biobank of lille * men and women aged ≥ 18 years * informed consent signed by the patient or his legal representative. main exclusion criteria: * antecedents of other cancers except basal cell skin cancer or carcinoma in situ of the uterus cervix * previous history of brain radiotherapy * anti-tumor systemic treatments (chemotherapy or targeted therapy) prior to surgery of glioma * genetic disease that may cause brain tumor, potentially radiation-induced tumor * history of degenerative neurological disease prior to diagnosis * contraindication to mri

Keywords: high grade glioma proteomics maldi-msi
study to evaluate the safety and pk of ui018

Conditions: Hyperlipemia, Mixed

Summary: this study is to evaluate the safety and pharmacokinetics of a fixed dose combination formulation and co-administration.


Eligibility criteria:
inclusion criteria: * healthy subjects between the ages of 19 and 45 years at screening * subjects whose body weight over 55 kg and ranged ± 20% of calculated ideal body weight(ibw) \[ ibw (kg) = (height(cm) - 100) x 0.9 \] * subjects able to read and understand a written informed consent, and willing to decide to participate in the study.
post-operative anxiety and depression among older adults who undergo surgery for fragility fractures

Conditions: Fractures in the Elderly

Summary: patients who present with falls and fractures can experience increased symptoms of depression and anxiety due to the trauma of falling, hospitalisation and surgery. additionally after surgery, patients may be limited in their mobility, resulting in a loss in their independence which can lead to further feelings of frustration and helplessness. in this study we want to know how common this problem is among older people who are admitted to hospital with broken bones and subsequently receiving surgery. we will use a questionnaire called the hospital anxiety and depression scale (hads) to explore this. we will recruit 60 patients for this study, 30 participants who received operative management and a further 30 participants who did not receive surgery for comparison. patients who are not able to consent to the study or those who are not able to complete the questionnaire will not be recruited. we will collect routine data from the patients to provide a description of the patients that we are studying. patients will complete the hads questionnaire once during their hospital stay and then in 1 month's time. we will contact patients through telephone for the 1 month follow up. this study will enable us to determine how common are the symptoms of anxiety and depression among this group of patients. this will help raise awareness of the problem which may prompt further intervention and management plan to address this important issue.


Eligibility criteria:
inclusion criteria: * age 65 years and above * received operative or non-operative management of fragility fracture * able to provide written consent exclusion criteria: * patients receiving end of life care * patients with known diagnosis of severe dementia and/ or lack capacity to consent * non-fragility fracture

Keywords: fragility fracture anxiety depression surgery
does pulmonary rehabilitation improve balance in people with respiratory disease?

Conditions: Lung Diseases

Summary: the purpose of this study is to determine whether participation in pulmonary rehabilitation improves balance in people with respiratory disease.

falls and chronic respiratory are two major health concerns affecting morbidity and mortality in older adults. several factors that predispose falls, such as reduced balance, have been documented in people with respiratory disease. pulmonary rehabilitation programs, which involve customized exercise prescription, are recommended to improve quality of life and disease management in people with chronic obstructive pulmonary disease (copd). there are many documented benefits to participation in such programs; however, the impact on balance and other falls risk factors has not previously been investigated. therefore, the aim of this study is to investigate the effect of a pulmonary rehabilitation program on balance and falls risk factors in individuals with respiratory disease. this study will enhance the current management of respiratory disease by improving our understanding of the effects of pulmonary rehabilitation.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of lung disease * committed to regular attendance at pulmonary rehabilitation program * a forced expiratory volume in 1 second (fev1) \< 80% of predicted * no change in medications for the past 2 months exclusion criteria: * unstable cardiac disease * neurological conditions * musculoskeletal conditions that prevent participation in exercise sessions.
evaluation of three strategies based on vaginal self-sampling kit send to home of unscreened women for cervical cancer

Conditions: Cervical Cancer Screening; Cervical Cancer

Summary: despite the existence of an effective screening test (pap smear), cervical cancer is, every year in france, the cause of more than 3,000 new cases and 1,100 deaths. but, in france, 4 in 10 women are not screened or not often enough (nearly 7 millions women). it is therefore necessary to develop new strategies to reach these women. the etiological factor of this cancer is persistent infection with high-risk human papillomavirus (hr-hpv). thereby, hpv-based tests could be alternative screening tests. vaginal self-sampling with hr-hpv test is simpler and less intrusive than the pap smear. it has been shown that sending vaginal self-sampling kit (with hpv test) to unscreened women's home is a powerful means to increase the participation rate of cervical cancer screening. it seems interesting to explore methods to increase the efficiency of this strategy by optimizing the ratio of the number of kits used compared to the number of kits sent. two approaches will be tested: a system "available on request" of the kit and / or the addition of an sms (short message service) reminder.


Eligibility criteria:
inclusion criteria: * women from 30 to 66 years old * women living in french territorial division 37 ("indre-et-loire") * women with a mobile phone in database * women who do not perform a pap smear in the last 4 years * women who do not answer to a first "invitation" letter to perform a pap smear exclusion criteria: * stop sms * hpv cervical pathology during treatment * hysterectomy including cervix

Keywords: vaginal self-sampling cervical cancer screening papillomavirus hpv high risk human papillomavirus infection pap smear
effects of cognitive-motor exergame using dividat senso on physical and cognitive function in stroke patients

Conditions: Stroke

Summary: the objective of this randomized controlled trial is to assess whether exergaming using the dividat senso platform more effectively enhances physical and cognitive functions in patients with chronic stroke compared to standard balance exercises. the primary questions it seeks to answer are: * does exergaming with the dividat senso lead to greater improvements in physical function, as measured by outcomes such as the functional gait assessment and the short physical performance battery? * does exergaming with the dividat senso result in greater enhancements in cognitive function, evaluated through measures such as the trail making test (parts a and b) and the stroop test? researchers will compare two groups: * an exergame group, receiving exergaming with the dividat senso in addition to standard rehabilitation. * a control group, receiving standard balance exercises. participants will: * undergo a four-week training period, consisting of five sessions per week, with each session lasting 30 minutes. * receive standard rehabilitation, including neurodevelopmental treatment and occupational therapy, alongside their assigned balance or exergame exercises. * complete baseline and post-intervention assessments of physical function (using the functional gait assessment and the short physical performance battery) and cognitive function (using the trail making test and the stroop test). * during each exergame session, participants in the exergame group will interact with the dividat senso platform, performing weight-shifting, stepping, and task-oriented balancing exercises guided by real-time feedback on a virtual interface. * participants in the control group will perform standard balance exercises emphasizing weight transfer in anterior-posterior and medial-lateral directions. this study aims to clarify the efficacy of exergaming as a dual-task intervention for chronic stroke rehabilitation, potentially offering a more engaging and effective approach to improving both motor and cognitive functions.


Eligibility criteria:
inclusion criteria: * diagnosis of chronic stroke (≥6 months post-stroke) confirmed by medical records * a score of 21 or higher on the korean version of the mini-mental state examination * ability to walk independently ≥10 meters with or without assistive devices exclusion criteria: * hemianopia * other neurological disorders (e.g., parkinson's disease, multiple sclerosis) * progressive or uncontrolled medical conditions (e.g., unstable cardiac disease, uncontrolled diabetes) * musculoskeletal conditions that could interfere with balance or gait performance * participation in other interventional studies within the past year
a savings intervention to reduce men's engagement in hiv risk behaviors

Conditions: Human Immunodeficiency Virus; STI; Alcohol Consumption; Incentives; Behavior

Summary: this randomized control trial will test an economic intervention to reduce kenyan men's engagement in behaviors that increase the risk of hiv/stis. participants randomized to the intervention group will be able to open accounts with a partner bank and will be incentivized to save with lottery-based rewards.

this project will evaluate an innovative, theoretically-motivated economic intervention to reduce men's engagement in transactional sex and other risky behaviors. leveraging innovations in mobile financial services and research on savings behavior in low-income countries, the investigators propose to test an intervention that seeks to motivate high-risk, income-earning men in western kenya to reduce their spending on risky behaviors and instead save their disposable income in local bank accounts. these bank accounts will include additional incentives to save in the form of lottery-based rewards linked to amounts saved. the intervention will also encourage participants to develop savings goals and strategies, and provide periodic reminders about saving regularly. through a direct economic mechanism (incentives to shift expenditures from the present to the future) and a psychological mechanism (increasing future orientation), the investigators hypothesize that the intervention will result in increased savings, reduced spending on transactional sex and alcohol, less risky sexual behavior, and reduced risk of hiv and sexually transmitted infections (stis). the investigators will conduct a randomized controlled trial among men who are at high risk of hiv and sti infection and determine the effects of a savings intervention on health and economic outcomes. specific aims of the project are as follows. aim 1: determine the impact of the intervention on savings and investment behavior, self-reported sexual behavior, and incidence of hiv/stis. aim 2: quantitatively and qualitatively assess mechanisms of behavior change among participants and a sample of their female partners.

Eligibility criteria:
inclusion criteria: * male * age 18-39 years * resides in study community and plans to remain for the next 2 years * used alcohol or other substances in the past month * engagement in any transactional sex (defined as payment of money, goods, or services in exchange for sex) in the past 3 months * has a steady income source that typically results in earnings every week * owns mobile phone * already has or is willing to open an account with partner banking institution * has national identification card (required for opening bank account) * has kenya revenue authority personal identification number or is willing to create one (required for opening bank account) exclusion criteria: * none
a study of the trabecular micro-bypass stent in combination with cataract surgery in subjects with open angle glaucoma

Conditions: Open-Angle Glaucoma

Summary: the purpose of this study is to evaluate the safety and efficacy of the istent trabecular micro-bypass stent in reducing intraocular pressure (iop) in subjects with open-angle glaucoma or ocular hypertension and co-existing cataract.

the purpose of this study is to evaluate the safety and efficacy of the istent trabecular micro-bypass stent in reducing intraocular pressure (iop) in subjects with open-angle glaucoma or ocular hypertension and co-existing cataract. pre-operative unmedicated baseline pressures will be compared with post operative values in both study arms.

Eligibility criteria:
inclusion criteria: * diagnosed with open-angle glaucoma (oag) in the study eye. pseudoexfoliative and pigmentary glaucoma are also acceptable diagnoses. * subject on at least one glaucoma medication * able and willing to attend follow up visits for two years post operative * able and willing to sign informed consent exclusion criteria: * prior glaucoma procedures (eg trabeculectomy, viscocanalostomy, alt, slt, shunt implant, collagen implant, cyclo destructive procedures etc) * angle closure glaucoma * fellow eye already enrolled

Keywords: open angle glaucoma cataract surgery
imaging biomarkers of mild traumatic brain injury: a longitudinal cohort study

Conditions: Mild Traumatic Brain Injury; Posttraumatic Stress Disorder; Affective and Somatic Complaints; Cognitive Impairments

Summary: this longitudinal cohort study aims to detect the topographical nature of the white matter microstructure and resting state functional connectivity patterns across the whole brain in the evolution of pathology as a function of time following mild tbi. all consecutively patients with the non-contrast head ct because of acute head trauma from the local emergency department (ed) formed the initial population of this study. age, sex, education-level matched healthy controls will also be enrolled. the initial scan will performed within 7 days post-injury. clinical assessment was performed within 24 hours of mr imaging and included a broad neuropsychological and symptom assessments. follow-up examination will conduct at 1 month, 3 month, 6-12 months.


Eligibility criteria:
inclusion criteria: * glasgow coma score of 13-15; * one or more of the following: loss of consciousness (if present) \< 30 min, post-traumatic amnesia (if present) \< 24 h, and/or other transient neurological abnormalities such as focal signs, seizure, and intracranial lesion not requiring surgery. * no contraindications to mri; * injury within 7 days; * agreement to communicate by telephone or e-mail for 1, 3 to 6-12 months after enrollment and come back to the hospital for follow-up exclusion criteria: * history of neurological disease * head injury, or history of substance or alcohol abuse, intubation and/or presence of a skull fracture * administration of sedatives on arrival in the emergency department * spinal cord injury, manifestation of mild tbi due to other injuries (e.g., systemic injuries, facial injuries, or intubation) or other problems (e.g., psychological trauma, language barrier, or coexisting medical conditions), or caused by penetrating craniocerebral injury.
the effect of a passive shoulder exoskeleton and muscle fatigue on occupational work performance

Conditions: Fatigue; Muscle Strain; Physical Stress

Summary: in this investigation, participants perform simulated occupational work during which the task performance will be logged. this research investigates the effect of peripheral fatigue and a passive shoulder exoskeleton on the task performance.


Eligibility criteria:
inclusion criteria: * healthy (based on parq questionnaire) * right handed exclusion criteria: * current musculoskeletal disorder * history of recurrent musculoskeletal discorder

Keywords: peripheral fatigue overhead work task performance ergonomics effort
early detection of covid-19 using breath analysis

Conditions: Covid19

Summary: early detection of covid-19 using breath analysis- first cross-sectional study

primary objective- to identify and evaluate a set of biomarkers that represent both the genetic expression of the virus itself (sars-cov-2) and the metabolic activity of the immune system's response to the virus.

Eligibility criteria:
inclusion criteria: * age 18 to 55 years at the time of consent * positive results for sars-cov-2 * capable of understanding written and/or spoken language * able to provide informed consent exclusion criteria: * age under 18 years old * (anticipated) inability to complete breath sampling procedure due to e.g. hyper- or hypoventilation, respiratory failure, or claustrophobia when wearing the sampling mask * persons under guardianship or deprived of liberty * patients with the following diseases: cancer, asthma, chronic respiratory disease * pregnant women * treated with antiviral drugs upon admission or during hospitalization * novices and soldiers in initial training
serologic characterization of bone-healing

Conditions: Arthritis

Summary: investigation of serologic bone markers in patients undergoing hip arthroplasty

investigation of serologic bone markers in patients undergoing hip arthroplasty. measured by frequent blood- and urine samples pre-operative and during the first post-operative year.

Eligibility criteria:
inclusion criteria: * ages 40-80 years

Keywords: tha
the effect of whole beans on inflammation and satiety

Conditions: Metabolic Syndrome

Summary: determine whether eating beans with a high fat meal will reduce the inflammatory response in people with the metabolic syndrome and increase feelings of satiety.

determine whether eating beans with a high fat meal will reduce the inflammatory response in people with the metabolic syndrome; thereby possibly postponing the diagnosis of diabetes or other chronic inflammatory diseases. these researchers are also interested in how consuming beans can affect the length of time a person stays full after a meal.

Eligibility criteria:
inclusion criteria: men and women 21 years old and older with metabolic syndrome exclusion criteria: 1. smokers 2. female subjects who are pregnant or lactating 3. subjects taking any medications that would interfere with outcomes of the study i.e. lipid lowering medications, anti-inflammatory drugs (i.e. ibuprofen), dietary supplements 4. subjects with any known allergy or intolerance to foods involved in the study(cantaloupe, egg, dairy, wheat, beans, couscous, grape seed extract) 5. subjects who are actively trying to lose weight 6. subjects with unusual dietary habits (i.e. pica, anorexia nervosa, extreme food restriction, binging and/or purging disorders) 7. subjects who are addicted to drugs or alcohol or who are \<1 year recovery program 8. subjects who present with significant psychiatric or neurological disturbances as determined by the primary investigator (i.e. uncontrolled bipolar disorder) these subjects will be referred to their primary care doctor for further care. 9. subjects with documented atherosclerotic disease, inflammatory disease, diabetes mellitus (fasting blood sugar ≥126 mg/dl), uncontrolled hypertension (≥ 140/90mmhg), liver and kidney disease as identified by routine blood tests (chemistry panels). these subjects will be referred to their primary care doctor for further care.

Keywords: metabolic syndrome inflammation antioxidants satiety fiber
effectiveness of brainwave biofeedback in the treatment of fibromyalgia

Conditions: Fibromyalgia

Summary: the purpose of this study is to determine whether a new form of brainwave biofeedback is effective in the treatment of fibromyalgia.

fibromyalgia (fm) is a chronic disorder that involves chronic widespread musculoskeletal pain typically accompanied by fatigue, disordered sleep, cognitive complaints, psychological distress, and impairments in functioning. treatments to date have been only partially effective and typically of modest benefit. many persons with fm remain persistently dysfunctional and often disabled. this has given greater impetus for patients to seek complementary and alternative medicine (cam) therapies. in this study, a variant of electroencephalograph (eeg) biofeedback known as low energy neurofeedback system (lens) will be used to reduce fm symptoms. participants in this study will be randomly assigned to receive either lens or placebo for several sessions. the fibromyalgia impact questionnaire will be used to assess participants at the end of the study and at the 3- and 6- month follow-up visits.

Eligibility criteria:
inclusion criteria: * diagnosis of fibromyalgia with symptoms for at least 1 year * self-report of having attention/concentration, memory, multi-tasking or other thinking difficulties * able to read and understand english * able to attend treatment sessions weekly and return for planned follow-ups * appropriate balance of average delta (\<4 hertz) eeg waveband and alpha (approximately 4-8 hertz) eeg waveband amplitude on lens screening (to be determined by study personnel); exclusion criteria: * other chronic pain condition of major significance * current chronic viral infection * current other unstable medical condition * history of spinal, including neck, surgery * psychological screening indicates psychotic, suicidal, homicidal, and/or substance abusing * use of long-acting opioid medication taken on a continuous 24-hour dosing schedule * current involved in litigation regarding pain condition or seeking disability * history of electroconvulsive therapy

Keywords: fibromyalgia electroencephalograph (eeg) biofeedback electromagnetic stimulation neurofeedback neurotherapy complementary and alternative medicine
impact of omega 3 fatty acid supplementation on aromatase in obese subjects

Conditions: Breast Cancer

Summary: assess the impact of dietary omega 3 free fatty acids and/or letrozole on obese, postmenopausal breast cancer patients.

prospective, comparative, three arm, short term, non-interventional study with correlative biomarker endpoints. sixty (60) obese (≥ 30 bmi) newly diagnosed er+ postmenopausal breast cancer patients will be recruited to participate in a short term (30 day) phase 0 biomarker evaluation study prior to surgical resection.

Eligibility criteria:
inclusion criteria: * at least 18 years of age. * postmenopausal as confirmed in medical history * ability to understand the purposes and risks of the study and has signed a written informed consent form approved by the investigator's irb (institutional review board)/ethics committee. * estrogen receptor positive breast cancer. body mass index of 30 or greater. * consented for tissue collection on ctrc (cancer therapy and research center) repository 07-32 exclusion criteria: * cachexia * active systemic illness (infection including viral illnesses such as hepatitis and hiv) * chronic use of nsaids (nonsteroidal anti-inflammatory drugs) aspirin or omega-3 free fatty acid supplementation within the last 60 days (defined as greater than or equal to 7 consecutive days) * any nsaids aspirin or omega-3 free fatty acid supplementation within the last 14 days * history of medical noncompliance * scheduled date of surgical resection that would limit the amount of time taking the intervention to less than 21 days