Kornimate/medical-research-clean huggingface dataset:
study of the correlation between post-traumatic stress disorder and paradoxical sleep behavior disorder

Conditions: Post Traumatic Stress Disorder; Sleep Disorder

Summary: post-traumatic stress disorder is a psychiatric disorder that occurs after a traumatic event and is estimated to affect 5 to 12% of the general population. around 70% of patients suffering from this disorder report sleep disorders (sleep apnea, insomnia, recurring nightmares, etc.). there are specific sleep disorders called rapid eye movement (rem) sleep behavior disorders which correspond to nocturnal restlessness with sometimes violent behavior, often associated with intense dreams during a phase of sleep called rem sleep. these disorders are more frequently found in patients suffering from post-traumatic stress, such as veterans. however, the physiopathological link between these two disorders is poorly understood and studies on this subject are few in number. through this study, the investigators wish to demonstrate whether there is a correlation between the severity of post-traumatic stress disorder and that of rapid eye movement sleep behavior disorder. the main objective is to study the relationship between the severity of post traumatic stress disorder (ptsd) and the rapid eye movement (rem) sleep behavior disorder. this is an observational prospective study based on 4 questionnaires relating to the sleep (psqi), the severity of the rapid eye movement (rem) sleep behavior disorder (rem rbdsq, irbd-sss) and the severity of the post-traumatic stress disorder (pcl-5).

type of study: observational prospective study study duration : 40 min, one visit at d0 (inclusion isit) number of center: 1 (clermont ferrand) patients: 60 patients suffering from type 1 post-traumatic stress disorder . patients will be selected during their consultation, at the cump (medico-psychological emergency cell) of the hospital of clermont-ferrand. if patients accept to participate to this study, demographic and clinical data (age, sex, current treatments, medical and surgical history) will be collected. then, they will complete 4 questionnaires : * the rapid eye movement behavior disorder screening questionnaire (rem rbdsq) * the rapid eye movement behavior disorder symptom severity scale score (irbdsss) * the quality of sleep inventory (psqi) * the posttraumatic stress disorder checklist for dsm-5 (pcl 5)

Eligibility criteria:
inclusion criteria: * adult patient aged 18 to 50 years. * french speaking. * having a diagnosis of type i posttraumatic stress disorder according to dsm 5. exclusion criteria: * presence of acute mental illnesses in the process of decompensation. * presence of a central nervous system disorder (e.g. neurodegenerative diseases, stroke, multiple sclerosis (ms), narcolepsy, etc.) * patient under guardianship, curatorship, or legal protection.

Keywords: post traumatic stress disorder sleep disorders rapid eye movement sleep behavior disorder data correlation
nursing students education virtual reality wound care

Conditions: Nurse's Role; Wound Heal; Prevention

Summary: this study is a randomized controlled trial aiming to determine the effect of pressure sore prevention education given to nursing students at a foundation university through virtual reality on student satisfaction, self-confidence perception and knowledge retention. the study will investigate whether virtual reality training affects student satisfaction and self-directed learning skills, differences between pre-test and post-test scores, and retention of the training. 66 nursing students will be included in the study, the experimental group will be trained with vr goggles and the control group will be provided with written material. the data obtained during the data collection process will be analyzed with the spss v23.0 program, descriptive statistics and appropriate parametric or nonparametric tests will be used. the measurement tools to be used include the 20-question "knowledge assessment form for pressure ulcer prevention" developed by jeffries \& rizzolo and the "student satisfaction and self-confidence in learning scale". ethics committee approval, relevant permissions and participant consent will be obtained for the study and the data obtained will be stored for 5 years and then destroyed. the literature review reveals the widespread use of virtual reality in education, healthcare and other fields and the critical role of pressure sore prevention in reducing healthcare costs and improving the quality of patient care.

this study will be conducted as a pre-test post-test randomized controlled trial to determine the effect of pressure sore prevention education on student satisfaction, self-confidence perception, and knowledge retention at ankara medipol university department of nursing. data will be collected from 70 nursing students through an online survey, the experimental group will be trained with vr goggles, while the control group will be provided with written material. data collection will take place in five phases: pre-test, training, post-test, satisfaction and confidence assessment, and a retention test after three months. the measurement tools to be used include the 20-question "knowledge assessment form for pressure ulcer prevention" developed by jeffries \& rizzolo and the "student satisfaction and confidence in learning scale". data will be analyzed in spss v23.0 and appropriate parametric or nonparametric tests will be applied. data will be collected between march 2025 and july 2025 and will be stored for five years and then destroyed.

Eligibility criteria:
i̇nclusion criteria * nursing students, * 2nd year nursing student exclusion criteria * not a nursing student * 1st, 3rd or 4th year nursing student

Keywords: nursing virtual reality wound care
study to gather information on the acceptability of a new flavor system with increasing levels of 2, 4, 6 g or higher of mannitol for peg 3350 in subjects having infrequent bowel movements.

Conditions: Constipation

Summary: study to gather information on the acceptability of a new flavor system with increasing levels of 2, 4, 6 g or higher of the sugar alcohol mannitol for polyethylene glycol (peg) 3350 a drug stimulating bowel movement to pass stool in subjects having infrequent bowel movements. the taste of the various preparations will be measured by use of a rating scale.


Eligibility criteria:
male and female subjects, aged 18 years and older, suffering with occasional constipation
a clinical study of insc intervent cerebral hemorrhagic stroke

Conditions: Stroke, Ischemic

Summary: this is a single centre、single arm、open-label，to investigate the safety and efficacy of induction of neural stem cells transplantation in the brain


Eligibility criteria:
inclusion criteria: 1. have the ability to understand the requirements of the study, provide written informed consent, and comply with the study procedures. 2. men and women 30-65 years old. 3. women must have a negative serum pregnancy test, gestation age women practice an acceptable method of contraception. 4. at least 12 months but no more than 60 months from time of hemorrhagic stroke, with a motor neurological deficit. 5. documented history of single hemorrhagic stroke in subcortical region of mca or lenticulostriate artery with or without cortical involvement, with correlated findings by mri. 6. modified rankin score of 2, 3 or 4. 7. fmms score of 55 or less, two evaluations at approximately 3 weeks apart prior to surgery with less than +/- 5 point change in the fmms. 8. two evaluations at approximately 3 weeks apart prior to surgery with less than +/- 4 point change in the nihss. 9. able and willing to undergo post-physical therapy/rehabilitation. exclusion criteria: 1. any disabling psychological or psychiatric disorders which may confound the study. 2. history of more than one hemorrhagic stroke. 3. history of another major neurological disease or injury. 4. cerebral soften lesion size \>5cm in any one measurement. 5. myocardial infarction within the prior 3 months. 6. history of seizures or current use of antiepileptic medication. 7. history of peripheral nerve surgery, including selective dorsal rhizotomy and contralateral seventh cervical nerve transfer. 8. receipt of any investigational drug or device within 30 days. 9. receipt of any cell infusion other than blood transfusion. 10. any concomitant medical disease or condition noted below: 1. coagulopathy. 2. active or history of malignancy. 3. primary or secondary immune deficiency. 4. persistent mri artifact or unable to undergo mri. 11. any condition that the investigator or primary physician feels may interfere with participation in the study or may endanger the subject. 12. any condition that the surgeon feels may pose complications for the surgery.
sedentary behavior in african americans

Conditions: Cardiovascular Disease

Summary: the study is designed to develop methods for objectively measuring sedentary behavior, assess the association between objectively measured sedentary behavior and cardiovascular disease outcomes, and develop an intervention to reduce sedentary behavior, in african american adults.


Eligibility criteria:
inclusion criteria: * self-classify yourself as african american * are aged 18 years or older * are free of serious medical condition, such as cancer, cardiovascular disease, or emphysema. * are free of serious medical conditions that would prevent participant from engaging in physical activity. * are willing to have a scan completed that measures your body composition * are willing to stay in metabolic chamber for 8.5 hours (8:00am until 4:30 pm) * are willing to wear an accelerometer for 2, one-week periods following your chamber stay. there will be one week in-between the 2, one-week periods. * are willing to complete questionnaire related to your level of activity * weigh less than 250 lbs. exclusion criteria: * unwilling or unable to perform activities in protocol * on medications * a woman who is intending to become pregnant, or who is pregnant
diagnostic precision study on vibration induced nystagmus test for scds by ortofone b250 skull vibration protocol

Conditions: Superior Canal Dehiscence Syndrome; Vestibular Disorder

Summary: to study the videonystagmography response to a bone conducted vibration on the mastoid by b250 bone transducer in patients affected by vestibular loss, menieres disease and superior semicircular canal dehiscence syndrome vs healthy control subjects


Eligibility criteria:
inclusion criteria: patients affected by certain vestibular disorders. exclusion criteria: patients with vertigo and dizziness without certain diagnosis.
turkish validation of the drooling impact scale

Conditions: Hypersalivation; Cerebral Palsy

Summary: the aim of this study is to investigate the reliability and construct validity of the turkish version of the drooling impact scale in children with cerebral palsy

drooling is common among several neurologic disorders such as cerebral palsy, parkinson's disease, amyotrophic lateral sclerosis, which are the main diseases that physiatrist are one of the leading physicians involved in whose management 1. drooling can be seen either as anterior drooling, unintentional leaving of saliva from mouth to outside of the body, or posterior drooling, invisible spill of saliva from mouth through pharyngeal isthmus and then to respiratory or digestive tract, inside the body 2. anterior drooling causes psycho-social impairment, skin problems, infections, bad odor, dehydration, dentation problems and wet clothes and tools while posterior drooling may result in morbidity by posing a risk for aspiration pneumonia. despite the frequency and significance of the condition, there is still a paucity of research and inadequate evidence about the various treatments and valid and reliable outcomes available. a major problem for research into interventions to reduce drooling is that there is no valid and reliable measurement tool of saliva control. there is no questionnaire in turkish to evaluate the effects of drooling as well as drooling interventions.the aim of this study is to investigate the reliability and construct validity of the turkish version of the drooling impact scale in children with cerebral palsy.

Eligibility criteria:
inclusion criteria: 1. patients with unilateral or bilateral cerebral palsy at between the ages of 4-16 2. spastic, dyskinetic or mixed type cerebral palsy 3. gmfcs level 3,4,5 4. stable drooling within at least one month exclusion criteria: 1. active infection of salivary glands 2. upper respiratory tract infection at the time of testing 3. history of anticholinergic drug intake in the past three weeks 4. occurance of any above between test and re-test assessment that may interfere with the results

Keywords: cerebral palsy drooling impact scale hypersalivation validity
ultrasonography-guided and surgical rectus sheath block in single-port access laparoscopy

Conditions: Pain

Summary: rectus sheath block is effective in reducing pain in the peri-umbilical region, and the use of ultrasonography is recommended to perform the block at the precise location. recently, intra-operative rectus sheath block has also been introduced without the aid of ultrasonography. however, no study has not yet compared the analgesic effects of these two different approaches (ultrasonography-guided vs direct surgical). thus, the aim of our study is to compare the effect of ultrasonography-guided and direct-surgical rectus sheath block after single-port access laparoscopy in benign ovary cyst patients.

this is a randomized, prospective study comparing the analgesic effects of ultrasonography-guided and direct-surgical rectus sheath block after single-port access laparoscopy in benign ovary cyst patients. patients will be randomly divided into 3 groups based on the procedure: control group, ultrasonography group and direct injection group. each group consists of 30 patients. * control group normal saline 10ml will be injected under ultrasonography guidance into the right, left rectus sheath at the end of the operation before emergence from general anesthesia. * ultrasonography group local anesthetic (ropivacaine 0.75% 10 ml) will be injected under ultrasonography guidance into the right left rectus sheath at the end of the operation before emergence from general anesthesia. * direct injection group local anesthetic (ropivacaine 0.75% 10 ml) will be injected under direct visualization into the right, left rectus sheath at the end of the operation before emergence from general anesthesia. analgesic efficiency will be assessed using the vas (visual analogue scale) pain scale and the total amount of self-administered fentanyl via pca (patient controlled analgesia) devices at multiple time scales (1, 6, 10, 24 and 48 hours after surgery). we will also compare the incidence of fentanyl complications, such as nausea, vomiting, pruritus and dizziness

Eligibility criteria:
inclusion criteria: 1. patients scheduled for a single port laparoscopic surgery at chung nam university hospital due to benign tumor of the ovary or the fallopian tube 2. between age of twenty to seventy 3. patients with a physical rating of 1 or 2 according to the american anesthesiology guidelines 4. patients who have not had laparoscopic surgery within two months exclusion criteria: 1. hysterectomy via single port laparoscopic surgery 2. patients with chronic pelvic pain 3. abdominal pain of unknown origin 4. suspected malignant tumor 5. diagnosed with malignant tumor of any origin 6. patients currently taking psychiatric medicine 7. pregnancy 8. patients with a history of hypersensitivity to amide type local anesthetics 9. patients with a history of hypersensitivity to opioid 10. risk of bleeding 11. unable to comprehend or does not agree to the consent form

Keywords: rectus sheath block single port laparoscopy
study of the families moving forward website behavioral intervention for teachers of students with fetal alcohol spectrum disorder

Conditions: Fetal Alcohol Spectrum Disorders

Summary: the purpose of this study is to find out if the fmf connect teacher companion website is acceptable and usable by teachers. the fmf connect teacher companion website is a website for teachers adapted from the families moving forward (fmf) program. the fmf program is an evidence-based intervention for caregivers of children with fasd. the study will determine if the a web page intervention is feasible and acceptable by looking at enrollment and retention of study subjects and acceptability of assessments.


Eligibility criteria:
inclusion criteria: * be an educational professional currently actively employed in a school setting in the united states * be above the age of 18 years old * have direct, consistent contact with a student with a diagnosed fetal alcohol spectrum disorder (fasd) or confirmed prenatal alcohol exposure (pae) between the ages of 5-12, (i.e. grades k to 5) in a special or general education classroom * have reliable access to the internet * be able to consent for themselves exclusion criteria: * they are unable to read english * they do not have direct, consistent contact with a student with a diagnosed fasd between ages 5-12 (e.g., substitute teacher, principal)
efficacy of a disease management program in very old patients with heart failure

Conditions: Heart Failure; Comorbidity; Case-manager

Summary: the purpose of this study is to assess the efficacy of a disease management programme (dmp) for very old patients with hf and significant co-morbidity. methods: a multicenter randomized trial will be conducted with 700 patients with heart failure, aged over 75 years, admitted to the acute-care units of the geriatrics departments in 8 hospitals. patients will be randomly allocated to a dmp or to conventional usual-care. randomization will be stratified by hospital and performed with concealment of the allocation list. the dmp will be conducted by a case manager, and will include three main components: 1. patient education to improve disease' knowledge and self-care 2. monitoring of clinical status 3. therapeutic adherence. main statistical analyses will be performed according to the intention-to-treat principle, and will use cox regression models to examine the association of a dmp with hospital readmission, quality-of-life, and mortality over 12 months.


Eligibility criteria:
inclusion criteria: 1. age:75 y or older 2. co-morbidity or dependency. at least one of the following criteria: charlson index \>3, dependency in 2 or more basic activities of daily living,treatment with 5 or more drugs, urgent hospitalization in the last 3 months, three or more diseases with active treatment, limitation in daily living because of vision or hearing impairment, cognition deficit, parkinson disease, diabetes mellitus, chronic obstructive lung disease, severe anemia, constitutional syndrome 3. hospital admission with a main diagnosis of heart failure (according to the criteria of the european society of cardiology or framingham criteria) in nyha functional class ii-iv. exclusion criteria: 1. participation refusal 2. terminal illness 3. cognitive decline or severe cognitive deficit, which does not permit a minimum knowledge of the disease, or lack of carers which give consent to study participation 4. clinical instability as assessed with the kosecof index 5. being in waiting list for organ transplant or cardiac surgery 6. inability to be followed-up because of other reasons (change of place of residence,..) 7. institutionalization

Keywords: heart failure elderly disease management
intrasaccular neck occlusion device treatment of intracranial aneurysm in acute subarachnoid hemorrhage

Conditions: Subarachnoid Hemorrhage; Subarachnoid Hemorrhage, Aneurysmal

Summary: rationale: intrasaccular neck occlusion devices have been used for unruptured aneurysm without safety concerns and good occlusion rates. in the setting of a subarachnoid hemorrhage, they could improve the rate of complete occlusion without safety concerns. aim: to explore the safety and efficacy of intrasaccular neck occlusion devices in patients with acute subarachnoid hemorrhage caused by a ruptured saccular aneurysm by a one arm prospective registry. study outcome: the primary outcomes is the rate of complete occlusion (raymond-roy i) and rebleeding at one year follow-up. the primary safety outcome is rate of rebleeding during the admission.


Eligibility criteria:
inclusion criteria: * acute subarachnoid hemorrhage due to an intracranial ruptured aneurysm. diagnosis must be done with acute ct or mri. * intracranial saccular aneurysm with neck diameter 2-11mm and neck-dome height ≥2 mm. * clinical severity measured by world federation neurological surgeons scale score ≤ iii. * age ≥18 years. * previous modified rankin scale ≤2. * informed consent obtained from the patient or acceptable patient surrogate. exclusion criteria: * hemodynamically unstable patients with requirement of advanced vital support. * patients with limited life expectancy (\<6 months) due to terminal disease. * previous antiplatelet or anticoagulation treatment. * participation in any other clinical trial with a drug or device which could influence the outcome. * patients with neurological or psychiatric disease that could undermine future evaluations. * lack of availability for 12 months tracing.
study to evaluate the clinical value and safety of xiyanping injection in the treatment of acute exacerbation of chronic obstructive pulmonary disease(copd) based on real-world clinical data

Conditions: Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Summary: the primary objective is to evaluate the effect of xiyanping injection on the treatment course of intravenous antibiotics for acute exacerbation of chronic obstructive pulmonary disease based on real-world clinical data, and to provide guidance and basis for the clinical application of xiyanping injection combined with antibiotics in the treatment of acute exacerbation of chronic obstructive pulmonary disease.the secondary objectives is to evaluate the effect of xiyanping injection on the indicators of acute exacerbation of inflammation and symptom improvement of chronic obstructive pulmonary disease.


Eligibility criteria:
inclusion criteria: 1. discharged with chronic obstructive pulmonary disease; 2. hospitalized patients with copd or aecopd combined with lower respiratory tract infection; 3. the treatment course of xiyanping injection in the exposed group was ≥3 days, and the non-exposed group did not use xiyanping injection; 4. study patients with complete medical records. exclusion criteria: 1. researchers believe that multiple proprietary chinese medicines with the same or similar functions (such as tanreqing injection, reduning injection, yanhuning injection, etc.) have been used at the same time during treatment, resulting in no assessment of efficacy or safety; 2. patients with viral pneumonia or other systemic infection (such as urinary tract infection); 3. patients who do not use intravenous antibiotics; 4. refuse the case to be used by researchers.

Keywords: acute exacerbation of chronic obstructive pulmonary disease xiyanping injection