Kornimate/medical-research-clean huggingface dataset:
urdu translation and cross cultural validation of pedsql inventory infant scale parent report 1 to 12 months

Conditions: Infant Development

Summary: the current study aimed to translate and validate urdu version of that module from pedsql, to measure the "quality of life" outcomes for pakistan and urdu speaking people.

data will be collected by pedql infants scale parent report a mix method approach will be applied forward translation backward translation review of forward and backward translation the process of translation will be followed the guidelines in the translation manual. translators will translate the pedsql inventory infants scale parent report independently from each other in urdu language following the proper forward and backward translation procedure. data analysis quality of life pediatric population will assess through urdu translated version of pedsql inventory infants scale parent report. data will be analyzed through spss.

Eligibility criteria:
inclusion criteria: * parents of both genders included * parents of infant age 1 to 12 months were included. exclusion criteria: * parents suffering from psychological disorders * parents with severe behavior issue * parents who cannot understand urdu

Keywords: health related quality of life of infants
smart mom - smartphone management and responsive time for breastfeeding mothers

Conditions: Smartphone Addiction; Breastfeeding; Infant Behavior; Mother-Infant Interaction

Summary: in the last decade, infants are born into a social environment in which the smartphone has become an essential part of our lives. smartphone use draws the mother's attention during mother-infant interactions and thus may affect the infant development as well as maternal self-efficacy. however, the effects of smartphone use reduction among breastfeeding mothers during their interactions with their infants have not been studied yet. in the present study, we propose to evaluate a "smart mom" intervention that we have developed, to manage and reduce smartphone use during breastfeeding. the purpose of the study is to evaluate the effects of the smart mom intervention on breastfeeding mothers' biobehavioral mechanisms, self-efficacy and the socioemotional characteristics of their infants. this will extend our knowledge of the peculiarities of early mother-infant interactions in the digital era, when smartphones play a critical role.


Eligibility criteria:
inclusion criteria: * 3-6 months old infant * smartphone addiction scale' cut-off (31 and above) exclusion criteria: * no neurological disorders * no heart disease * no anxiety and depression * no use of psychiatric drugs

Keywords: smartphone addiction problematic smartphone use breastfeeding infant temperament mother-infant interaction
quantiferon gold test for detecting tuberculosis (tb) infection in hiv/aids patients in south africa

Conditions: Latent Tuberculosis; HIV

Summary: the purpose of this study is to use a cluster randomized trial to compare the effectiveness of linking the quantiferon-gold in-tube test (qgit) with routine cd4 testing to the routine use of the tuberculin skin test (tst), the current standard of care for diagnosing latent tuberculosis infection (ltbi) in south africa. the investigators hypothesize that qgit clinics will identify ltbi and initiate isoniazid preventive therapy (ipt) in a higher proportion of patients and in a significantly faster timeframe. the cost-effectiveness of linking qgit with routine cd4 compared to routine tst will also be evaluated, and the process of implementation of qgit into the routine cluster of differentiation 4 (cd4) blood draw will be evaluated using a mixed method approach to identify steps that can be modified for future scale-up of the intervention.

the investigators propose a cluster randomized trial in 16 hiv clinics in south africa to compare time to determine ltbi status in patients in clinics using qgit and tst and those with tst only. the investigators will take advantage of the excellent hiv services provided in south africa and link qgit with cd4 blood collection and provide the first evidence of an operational comparison between qgit and tst in hiv-infected patients in a country that accounts for one-third of the hiv-related tb in the world. the qgit study will contribute to the understanding of qgit performance and implementation in hiv-infected individuals. careful evaluation of the implementation and operational aspects of the program will provide useful knowledge for future scale-up in this and other hiv clinic settings.

Eligibility criteria:
inclusion criteria: * hiv-infected * \>= 18 years of age * attending one of the 14 clinics during the duration of the study * eligible to receive tst or ipt according to south africa guidelines exclusion criteria: * diagnosed with active tuberculosis * not eligible to receive tst or ipt according to south africa guidelines

Keywords: cluster randomized trial interferon-gamma tuberculin test operational comparison cost effectiveness qualitative evaluation
microwave ablation for pulmonary metastases from colorectal cancer

Conditions: Colorectal Cancer

Summary: (mwa) is the most recent development in the field of local ablative therapies. the aim of this study was to evaluate ct-guided percutaneous microwave (mw) ablation safety and efficacy in pulmonary metastases from colorectal cancer.

from june 2010 to june 2015, 48 unresectable lesions in 32 patients with pulmonary metastases from colorectal cancer were selected for ct-guided microwave ablation. patients were scheduled for a 1 and 3 month ct follow-up to evaluate lesion diameter.we retrospectively evaluated ct-guided percutaneous microwave (mw) ablation safety and efficacy in pulmonary metastases from colorectal cancer.

Eligibility criteria:
inclusion criteria: * unresectable pulmonary metastases from colorectal cancer. * diagnosis by ct, and confirmed by percutaneous puncture biopsy. * age range 18-70 years old. * eastern cooperative oncology group performance status 0-1. * life expectancy of more than 3 months. * adequate organ function. exclusion criteria: * resectable lung metastases. * life expectancy less than 3 months * patients with cardiac pacemaker, cerebral aneurysm clips, implanted electronic instruments or other metal materials. * coagulopathy with platelet count less than 50000. * active infectious disease. * age below 18 years. * pregnancy of breastfeeding.
prognostic measures in ambulatory care settings

Conditions: General Internal Medicine Patients

Summary: the primary objective of this prospective study is to develop a new method of classifying the prognosis of ambulatory patients according to their risk of long term mortality, institutionalization, morbidity (including the deterioration of pre-existing conditions or development of new problems) and functional deterioration.

specifically, from a random sample of 2000 patients taken from a cohort of established patients followed for at least three years in a general medicine practice, the objectives are: 1. to identify the demographic, clinical, and functional status variable that predict the risk of death, morbid events (e.g., the development of new complications or deterioration of existing conditions), or the deterioration in functional status using a half of the cohort chosen at random; 2. to combine these findings into a prognostic scale that can be employed in routine clinical practice; and 3. to validate the performance of this scale in the second half of the cohort. there are no interventions in this study. patients already under medical care by cornell physicians will be enrolled. the only requirements for patients are to complete the questionnaires on an annual basis.

Eligibility criteria:
inclusion criteria: 1. patients who are currently under the care of physicians at cornell internal medicine associates. exclusion criteria: 1. patients who do not wish to participate in the study. 2. patients who are not able to provide informed written consent.

Keywords: prognosis risk of death morbidity mortality quality of life
cognitive cueing and video intervention for gait in parkinson's disease

Conditions: Parkinson's Disease

Summary: the goal of this clinical trial is to learn if cognitive cueing (eg., prompting individuals to think about taking big-long steps while walking), either as a stand- alone intervention or combined with a personalized gait training video, can improve gait (walking), mobility, and balance confidence for individuals with parkinson's disease. the main questions it aims to answer are: 1. does focusing on cognitive cues while walking improve gait, mobility, and balance confidence for individuals with parkinson's disease? 2. does incorporating a personalized gait training video alongside cognitive cueing lead to amplified improvements in gait, mobility, and balance confidence for individuals with parkinson's disease? researchers will compare how gait, mobility, balance confidence and quality of life change over time for participants when they practice walking with and without a cognitive cue alone, and when they practice with using a personalized gait training video. the researchers are also interested in how participation in this trial will affect quality of life and conscious attention to gait. participants will * complete walking trials on an instrumented mat that records data on their walking ability. these trials will be undertaken without a cognitive cue and while participants mentally rehearse a series of 3 cognitive cues (take big long steps; walk heel-toe; stand up straight). * be informed about which of the 3 cues best improved their walking and will receive a personalized gait training video for at home practice. * complete online surveys that ask questions about their parkinson's disease, mobility, balance confidence quality of life and conscious attention to gait. * visit the research facility 3 to 4 times during the study to have their gait (walking), mobility, balance confidence, quality of life and conscious attention to gait assessed and reassessed. * practice both with and without their personalized video at home and keep a diary to record their practice sessions * participate in a brief interview to discuss their experiences with the training and their perceptions of the effectiveness of cognitive cues and video-recorded feedback


Eligibility criteria:
inclusion criteria: * be diagnosed with parkinson's disease * be fluent in english * be able to walk independently and without a walking aid for at least 10 minutes * have no other cognitive or neurological impairments (e.g., brain tumours, recent concussion, stroke, brain injury) exclusion criteria: * deep brain stimulation (dbs) implant * standardized mini mental state examination (smmse) score less than 24

Keywords: gait cueing balance mobility
management radiodermatitis in patients with breast or head and neck cancer

Conditions: Radiodermatitis

Summary: it aims to evaluate the efficacy of the chamomile recutita gel and urea cream in the prevention of radiodermatitis in patients with breast cancer or head and neck cancer undergoing radiotherapy. prophylactic trial will consist of a control group and two experimental groups, namely control group (usual care), experimental group 01 (usual care + topical application of the gel c. recutita) and experimental group 02 (usual care + topical application of urea based cream). the doses used in the different compounds are being in test since february 2014 by a dose-response curve study, using 6 groups with three doses of urea cream and three doses of c. recutita gel. the study will be conducted at the center for high complexity oncology at university hospital of brasília (cacon/hub), brazil. the degree of radiodermatitis is evaluated weekly, according to established criteria to classify the effects of radiotherapy, which identifies grades 0, 1, 2 , 3 and 4, according to the score of the radiation therapy oncology group - rtog. to evaluate the skin reaction will also be applied scale common terminology criteria for adverse events (ctcae) and radiation-induced skin reaction assessment scale (risras).

it is considered that patients undergoing radiotherapy in use gel based on c. recutita or use of cream based urea three times a day, concomitant radiotherapy, would present the following hypotheses: * null: equal incidence and severity of radiodermatitis when compared to the control group (usual care); * alternative 1: low incidence and severity of radiodermatitis when compared to patients who comprised the control group (usual care). * alternative 2: lower incidence and severity of radiodermatitis between the experimental groups (urea and chamomile).

Eligibility criteria:
inclusion criteria: * being an adult, over the age of 18 years old; * owning diagnosis of malignant breast or head and neck; * being first referred to the radiotherapy protocol; * agree to participate, expressing his acceptance by signing the informed consent form (icf); * present absence of dermatitis to initiation of radiotherapy; * demonstrate understanding of and conditions to continue the intervention in their home environment when needed. exclusion criteria: * reports of previous hypersensitivity reaction or presentation, during the research, adverse reaction to chamomile or any plant of the asteraceae or compositae family, or urea; * medical prescription for the procedure of data collection, some kind of intervention to prevent radiodermatitis; * withdrawal of the patient to remain in the study, independent of time.

Keywords: radiodermatitis head and neck neoplasms radiotherapy urea matricaria breast neoplasms chamomilla chamomile
clinical, radiological and microbiological outcomes of implants with two different connection configurations, a split-mouth rct.

Conditions: Bone Loss, Alveolar; Dental Implant Failed

Summary: this study designed as a randomized controlled split-mouth trial will be conducted at the dental clinic of the university of valencia. the aim will be to assess differences in clinical, radiological and microbiological outcomes between implants with 2 different connections: internal hexagon and conical connection. following the premises, to minimize the bias related to prosthetic phase and maximize the effect of connections on mbl changes, a 1abutment-1time protocol will be used. the study hypothesis is that there will be no statistically significant differences between both implant connections.


Eligibility criteria:
inclusion criteria: * able to sign an informed consent form * aged 25 years or more * any patient requiring two implant-supported crowns in the lower or upper jaw * kennedy class i, ii, and iii; * teeth extracted at least 6 months before implant placement; * sufficient bone volumes to accommodate dental implants without augmentation procedure exclusion criteria: * general medical and/or psychiatric contraindications to implant surgery, * pregnancy or nursing, * heavy smoking (more than 10 cigarettes/day), * treatment with anticoagulant drugs (international normalized ratio under 1.8), bisphosphonates, steroid therapy or anticonvulsants drugs. * no regenerated bone * untreated periodontal disease and inability of the patient to maintain reasonable oral hygiene according to study requirements. * patients with history of alcohol, narcotics or drug abuse. (alcoholism: more than two bottles of beer per day) * patients receiving radiotherapy, chemotherapy or any other immunosuppressive treatment, or who have been administered radiotherapy in the last 5 years. (patients through at any time received radiotherapy to the head and neck region should be excluded anyway.) * metabolic bone disorders * uncontrolled bleeding disorders such as: hemophilia, thrombocytopenia, granulocytopenia. * degenerative diseases. * osteoradionecrosis. * renal failure. * organ transplant recipients. * hiv positive. * malignant diseases. * diseases that compromise the immune system. * unbalanced diabetes mellitus. (hba1c above 6.5), uncontrolled endocrine diseases * psychotic diseases. * hypersensitivity to one of the components of the implant in general and titanium in particular. * women who are pregnant or lactating. * lack of patient cooperation. * parafunctional habits, such as bruxism or temporomandibular joint disease. * various pathologies of the oral mucosa for example: benign mucous pemphigoid, desquamative ginigivitis, erosive lichen planus, malignancy of oral cavity, bolus erosive diseases of the oral mucosa.
nomogram for predicting in-stent stenosis after pipeline embolization device treatment in patients with intracranial aneurysm

Conditions: Intracranial Aneurysm

Summary: intracranial aneurysms (ias) are the primary cause of non-traumatic subarachnoid hemorrhage with high morbidity and mortality. flow diverters, such as pipeline embolization devices (peds), are among the most effective methods for treating ias in recent years due to the maturity of interventional devices and minimally invasive techniques. unlike conventional stents, peds modify the hemodynamics within the parent artery and aneurysm sac, allowing blood flow from the aneurysm sac, thus facilitating endothelialization of the aneurysm neck. as a result, aneurysms are completely removed from circulation with time. however, about 5.1%-38.5% of ia patients develop in-stent stenosis (iss) even after successful ped implantation. iss increases the risk of retreatment and ischemic complications, thereby affecting the long-term prognosis of ia patients. therefore, preoperative determination of the patient's suitability for ped implantation can enhance patient-centered decision-making and improve the long-term prognosis of ia patients. although previous studies have evaluated the correlation between certain individual variables and iss, there are few comprehensive models predicting iss after ped treatment. nomograms have been widely used for prediction of tumor survival and cardiovascular events. nomograms incorporate multiple risk factors for predicting the patient's potential prognosis based on their individual risks. this study aimed to identify the predictors for iss after ped treatment and to create and verify a nomogram for assessing individual risk.


Eligibility criteria:
inclusion criteria: 1. patients aged18 to 75 years; 2. ias patients treated with peds; 3. patients whose parent artery did not have significant atherosclerotic stenosis; 4. patients who had at least one digital subtraction angiography (dsa) follow-up. exclusion criteria: 1. patients missing critical clinical baseline; 2. patients with inadequate dsa image quality for reliable assessment; 3. patients with comorbid cerebrovascular conditions, including arteriovenous fistulas and arteriovenous malformations; 4. patients without any follow-up information.

Keywords: intracranial aneurysm in-stent stenosis pipeline embolization device nomogram
medtronic observational study in the "real world" of implantable electronic cardiac devices

Conditions: Heart Failure

Summary: the observational study in the "real world" of implantable electronic cardiac devices will enable the construction of an electronic database with local access to clinical information, which will collect and disseminate epidemiologic data on demography, cardiovascular mortality and morbidity, and potential risk factors for a selected group of patients. these clinical variables will be analyzed against the data, as based in the programming of devices and the diagnostics. approved descriptive statistics and analyses will be made available via internet. the study will describe statistical indexes on sub-groups representing more than 10% of total of datasets. the study will be open to include any patient that had a medtronic electronic device implanted, pacemakers, icd, icd with crp. the study will be also adapted for devices implanted in the present and for devices to be implanted in patients in the future.

this study is a prospective, multicenter observational post market release study. it shall involve around 2,000 patients that are eligible for implantable cardiac pacemakers (ipg) implantation, 500 patients eligible for cardiac resynchronization pacemakers (crt-p) implantation, 1,000 patients eligible for the implantation of implantable cardioverter defibrillators with or without cardiac resynchronization pacemakers (cdi, crt-d), and around 20 centers in brazil. patients will be consecutively enrolled in centers among those selected for the implantation of a medtronic device in accordance with indications approved.

Eligibility criteria:
inclusion criteria: * patients older than18 years of age * patient agrees to participate in the study and is able to sign the data release form * high probability of adherence to follow-up requirements exclusion criteria: * patients who want to be enrolled in another clinical study during at the same time that he/she is part of observe study.

Keywords: "real world" electronic database with clinical information related to implantable cardiac devices.
unexpected diagnosis in right lower quadrant pain: right colon diverticulitis

Conditions: Diverticulitis, Colonic

Summary: background: acute right lower quadrant pain is a common symptom in emergency departments. the most common etiology is thought to be acute appendicitis. other etiologies may be overlooked. acute right colon diverticulitis is one of them. it is usually seen in male and young patients. it is more common in asian population and rare in western countries. ultrasonography (usg) and computed tomography (ct) are used for radiologic diagnosis. objectives: the aim of this study was to investigate the diagnosis, treatment and surgical management of right colon diverticulitis.

design: retrospective cross-sectional analysis setting: research and training hospital (tertiary care center) in our study, patients hospitalized in our hospital clinic between 2018 and 2022 with the diagnosis of right colon diverticulitis were retrospectively analyzed. age, gender, wses grade, whether surgery was performed or not, laboratory values, iv antibiotherapies given, length of hospitalization and mortality were evaluated. main outcome measures: the crp, the need for surgical intervention vs conservative treatment .

Eligibility criteria:
inclusion criteria: * patients diagnosed with right colonic diverticulitis exclusion criteria: * \<18 years of age

Keywords: acute diverticulitis right colon emergency pain
effect of low molecular weight heparin in freeze-thaw embryo transfer cycles in women with recurrent implantation failure

Conditions: Low Molecular Weight Heparin; Recurrent Implantation Failure; FET; IVF

Summary: recurrent implantation failure (rif) is considered a tough problem in assisted reproductive technology (art) without effective treatments. the effect of low molecular weight heparin (lmwh) in pregnancy outcomes is controversial. in addition, there are few reports on the role of lmwh in population with rif performing freeze-thaw embryo transfer (fet) cycles. the purpose of this study is to evaluate the effect of lmwh on pregnancy outcomes in women with fet cycles.


Eligibility criteria:
inclusion criteria: * women under or equal to the age of 40 when oocytes were retrieved; * the history of at least 2 failed fresh embryo transfer/fet cycles and cumulative transfer of ≥ 3 high-quality embryos or cumulative transfer of ≥ 2 blastocysts; * planning to fet after ivf or icsi cycles exclusion criteria: * women with untreated hydrosalpinx, uterine cavity occupying lesions (uterine adhesions, submucous fibroids, endometrial polyps, et al.); * women with abnormal anatomical structure of uterus (unicornuate uterus, bipedal uterus, et al.); * women with endometrial thickness (emt) \< 6mm on the day of transplantation; * women or their partner with abnormal chromosome karyotype (not including chromosome polymorphisms); * women with the history of recurrent spontaneous abortion (rsa); * women with a history of autoimmune or coagulation disorders; * women with contraindications to lmwh