Kornimate/medical-research-clean huggingface dataset:
cpet in evaluation of ph in copd patients

Conditions: COPD; Pulmonary Hypertension Secondary

Summary: * to evaluate the entire course of exercise during cpet in copd patients. * to study whether cpet, pfts and arterial blood gases could discriminate between copd patients with and without ph. * to study whether the existence of pulmonary hypertension in copd is related to characteristic findings in gas exchange and circulatory parameters during cardiopulmonary exercise testing (cpet).

(copd) is a common cause of pre-capillary pulmonary hypertension (ph). pulmonary hypertension (pht) is a common complication of copd and is determinant for the prognosis of copd. pht is defined as a mean pap of ≥ 25 mmhg measured by right heart catheterization at rest. exercise tolerance in patients with copd is reduced due to ventilatory limitation, gas exchange abnormalities, and deconditioning as the disease progresses, and this may impair functional capacity and the quality of life. copd patients usually terminate physical activity when the ventilatory requirement exceeds their maximal ventilatory capacity. if they have ph, the altered hemodynamic response may reduce their exercise capacity further. nowadays, despite the fact that ltot improves the survival of hypoxaemic patients, ph is still associated with lower survival rates . importantly, an elevated ppa was also associated with an increased risk of severe acute exacerbation in copd patients with moderate-to-severe airflow limitation . impaired exercise tolerance in copd patients would suggest that cardiopulmonary exercise test (cpet) is a valuable tool to reveal whether they have ph or not. transthoracic echocardiography (tte) is one such tool and is widely available and safe. in addition to its role in diagnosis, it can be used to screen for high-risk patient populations, to assess prognosis and to monitor disease stability and response to treatment.

Eligibility criteria:
inclusion criteria: * stable copd patients * with age ≥ 40 years. * prior to inclusion, the copd diagnosis was verified by spirometry before and after bronchodilation. * treatment was optimized and patients on regular medication. exclusion criteria: * patients who refuse to participate in the study. * patients underwent thorough pulmonary and cardiologic preinclusion screening, and those with pulmonary disease other than copd and emphysema. * arrhythmia * valvular or coronary heart disease * left ventricle dysfunction * obstructive sleep apnea syndrome * pulmonary embolism * systemic hypertension ≥160/90 mmhg * inflammatory disease * hyperthyroidism * renal failure * inability to exercise (due to orthopedic, neurologic or musculoskeletal problem).
nursing students and artificial intelligence

Conditions: Nursing Students

Summary: the aim of this observational study is to examine nursing students\&#39; readiness for medical ai and their anxiety about ai using a mixed method. the main question it aims to answer is: nursing students\&#39;; 1. what is their level of awareness of medical artificial intelligence? 2. what is their level of artificial intelligence anxiety? 3. is there a relationship between artificial intelligence awareness and anxiety levels? 4. what are the opinions of those who have artificial intelligence anxiety about artificial intelligence? in the 1st stage, nursing students answered the related survey questions online. in the 2nd stage, qualitative interviews were conducted with those with high ai anxiety scores and evaluated.


Eligibility criteria:
inclusion criteria: to be a student of necmettin erbakan university faculty of nursing to be a student of necmettin erbakan university kamil akkanat faculty of health sciences, department of nursing exclusion criteria: students who did not consent to participate were excluded
study of opa-15406 ointment in patients with atopic dermatitis

Conditions: Atopic Dermatitis

Summary: the purpose of this study is to assess the efficacy and safety of opa-15406 ointment in patients with atopic dermatitis.


Eligibility criteria:
inclusion criteria: * diagnosis of atopic dermatitis based on the criteria of hanifin and rajka exclusion criteria: * subjects who have an atopic dermatitis or contact dermatitis flare-up defined as a sudden intensification of atopic dermatitis. * subjects who have an active viral skin infection. * subjects with a current or history of malignancy.
predictors of antiretroviral pharmacokinetics in hiv-infected women with virologic suppression

Conditions: Human Immunodeficiency Virus

Summary: the investigators would like to carry out this study to measure drug levels in hiv-infected women that are taking anti-hiv medications. this study will determine the predictors of high drug levels and will assess the association of drug levels and adverse events in women.

there have been tremendous advances in the treatment of hiv by combining 3 to 4 of the 20 anti-hiv medications available. despite these advances, there remain several important complications related to the treatment, most importantly adverse events like nausea, diarrhea, liver toxicity and lipodystrophy (fat wasting or accumulation). some studies have found that drug levels are higher in women and that these higher drug levels are associated with the increased toxicity in women. the reasons for the higher drug levels remain unclear. it is unknown whether these relate to hormonal influences, drug metabolism, adherence, fat distribution, body size or other factors. for this reason, we would like to carry out this study to measure drug levels in hiv-infected women that are taking anti-hiv medications. this study will determine the predictors of high drug levels and will assess the association of drug levels and adverse events in women.

Eligibility criteria:
inclusion criteria: * are hiv infected * are 18 years old or older * a biologic woman * are taking their first combination anti-retroviral regimen that includes a protease inhibitor or a non-nucleoside reverse transcriptase inhibitor for the past three months with no changes in any part of the combination in that period * are taking either a protease inhibitor or an non-nucleoside reverse transcriptase inhibitor but not both * if taking a protease inhibitor, must be taking only one protease inhibitor excluding low dose ritonavir used as boosting * have a viral load \< 50 copies/ml on two occasions at least 1 month apart including a value at least three months before the baseline visit * have signed and dated a full informed consent exclusion criteria: * have difficulty participating in a trial due to non-adherence or substance abuse * pregnant or breast-feeding * have malignancy receiving systemic chemotherapy * have end-stage organ disease * have another significant non-hiv underlying disease that might impinge upon disease progression or death

Keywords: pharmacokinetics hiv infected women
implementing advance care planning conversation tools in family practice

Conditions: Frail Elderly Syndrome; Chronic Disease

Summary: this study evaluates the use of advance care planning conversation tools with patients attending their family doctor's office. patients complete tools about their values and wishes, and a health care provider uses a structured discussion tool to talk about the patient's health condition and future wishes. the patient's family member/substitute decision-maker is encouraged to attend and be part of the discussions.

structured tools are helpful for advance care planning. tools have been developed to help with advance care planning because it is a process which has multiple steps and people involved. this study will help health care teams in primary care learn to use the tools with frail or older seriously ill patients and will evaluate the perceptions of patients, family members and health care providers, as well as the impact of having the discussions on subsequent health care interactions the patient has. patients complete tools about their values and wishes, and a health care provider uses a structured discussion tool to talk about the patient's health condition and future wishes. the patient's family member/substitute decision-maker is encouraged to attend and be part of the discussions.

Eligibility criteria:
inclusion criteria: * age 60 or older * chronic condition that may reduce life expectancy as per physician's clinical judgement * able to communicate verbally in english and read english exclusion criteria: * unable to communicate verbally in english * unable to read english * cognitively unable to give informed consent (e.g. memory problems) as judged by referring physician or research assistant
the endothelial count in pxf

Conditions: Pseudoexfoliation Syndrome

Summary: pseudoexfoliation syndrome is a common disorder in egypt. it is one of the common causes of coexisting cataract and glaucoma. it may be associated with a less than normal endothelial count.

the corneal endothelium is essential for the maintenance of normal corneal hydration, thickness, and transparency. in patients with pseudoexfoliation syndrome , quantitative and qualitative morphological changes of the corneal endothelium have been demonstrated in specular and electron microscopic studies. specular microscopy is a non-invasive technique to access the structure and function of the corneal endothelium. our research question is to study endothelial cell count in patients with pseudoexfoliation syndrome \& compare it to age matched group.

Eligibility criteria:
inclusion criteria: * patients with pseudoexfoliation syndrome exclusion criteria: * patients with previous intra ocular surgeries. * patients with uveitis * patients with fuck's endothelial dystrophy
effect on primary dysmenorrhea

Conditions: Primary Dysmenorrhea

Summary: to investigate the potential benefits of a new oral contraceptive (sh t00658id) on alleviating complaints of dysmenorrhea associated with oral contraceptive use.


Eligibility criteria:
inclusion criteria: * otherwise healthy female subjects requesting contraception and suffering from primary dysmenorrhea with a sum score for dysmenorrheic pain intensity of \>/= 8 over 2 baseline cycles documented by a prospective self-rated sum pain score * age: 14 - 50 years (inclusive; smokers must not be older than 30 years) at the time point of informed consent * normal cervical smear not requiring further follow-up (a cervical smear has to be taken at the screening visit, or a normal result has to be available that was documented within the last 6 months before the screening visit) * women with cyclic menstrual bleeding, defined by a cycle length between 25 and 35 days and no amenorrheic cycles or cycles without withdrawal bleeding during the last 3 months prior to visit 1. * able to tolerate ibuprofen and willing to use only ibuprofen supplied for the study. exclusion criteria: * pregnancy or lactation (delivery, abortion, or lactation within three cycles before the start of treatment) * obesity: body mass index (bmi) \> 32 kg/m2 * hypersensitivity to any of the study drug ingredients * any diseases or conditions that might interfere with the conduct of the study or the interpretation of the results * presence or a history of venous or arterial thrombotic / thromboembolic events (e.g. deep venous thrombosis, pulmonary embolism, myocardial infarction) or of a cerebrovascular accident, including prodromi (e.g. transient ischemic attack, angina pectoris), and conditions that could increase the risk of suffering from any of the above mentioned disorders, e.g. a family history indicating a hereditary predispositionundiagnosed abnormal genital bleeding * abuse of alcohol, drugs, or medicines (e.g. laxatives) * other contraceptive methods: * sterilization * oral, vaginal or transdermal hormonal contraception during treatment * intra-uterine devices (iud) with or without hormone release still in place within 30 days of visit 1 * simultaneous participation in another clinical trial or participation in another clinical trial prior to study entry that might have an impact on the study objectives at the discretion of the investigator * major surgery scheduled for the study period

Keywords: primary dysmenorrhea oral contraception
the relationship between leisure activities and aging anxiety in women

Conditions: Aging; Anxiety; Premenopause; Womans Health

Summary: the goal of this observational study is to learn about the effect of leisure activities on aging anxiety of middle-aged (45-59) women. the main question it aims to answer is: do the leisure activities (doing sports, playing music instruments, doing handicrafts, writing, taking care of a pet, growing plants, dancing etc.) affect the aging anxiety level of middle-aged women? participants will be required to fill out a form querying their socio-demographic information, medical histories, and regular leisure activities. subsequently, the "aging anxiety scale for middle-aged women" will be applied.

in this study, women aged between 40 and 59 registered at the marmara university education family health center (fhc) in the tuzla district will be included. there are a total of 352 women in this age range registered with the fhc, and it is aimed to reach all of them. patients will be informed about the study by dr. buğu usanma koban via telephone, and they will be invited to the fhc for the administration of the questionnaire. after obtaining informed consent from those who agree to participate in the study, their personal information will be recorded through a face-to-face interview. subsequently, the aging anxiety scale for middle-aged women, developed by lee and you, and validated in turkish by aydın and kabasakal, will be applied to the participants. finally, volunteers will be asked to fill out a questionnaire specifying the types and frequencies of their leisure activities. spss (version 20.0, spss inc., chicago, il, usa) will be used for data analysis. descriptive statistical information will be presented as mean ± standard deviation or %, and a p-value less than 0.05 will be considered statistically significant. in the comparison of more than two independent groups that do not meet the assumptions of parametric tests, the kruskal-wallis analysis will be conducted. if the analysis is significant, groups will be subjected to pairwise mann-whitney u tests. to understand the relationship between leisure activities and aging anxiety, spearman correlation analysis will be conducted for parameters conforming to normal distribution, and pearson correlation analysis will be performed for parameters not conforming to normal distribution. the correlation coefficient (r value) will be specified.

Eligibility criteria:
inclusion criteria: * not having a medical condition that requires urgent intervention or hospitalization * not having psychological or physical barrier preventing communication. exclusion criteria: * a medical condition that requires urgent intervention or hospitalization * having a psychological or physical barrier preventing communication.

Keywords: aging women's health anxiety leisure activities
a regional partnership to improve outcomes through fatherhood engagement

Conditions: Substance Use; Child Abuse; Child Neglect; Fathers; Father-Child Relations

Summary: montefiore will engage fathers in families at risk of substance misuse in the bronx and neighboring communities. families will be referred from bronx and neighboring community-based child welfare systems, substance use disorder (sud) treatment providers, and medical providers if identified at risk of substance use concerns and will be randomly assigned to receive services as usual as part of the comparison group, or to receive enhanced services as part of the program group. enhanced services include: (1) motivational enhancement; (2) referral to healthy, empowered, resilient, and open (hero) dads fatherhood engagement program; (3) contingency management; and (4) case management.


Eligibility criteria:
inclusion criteria: * (i) is a custodial or non-custodial father, * (ii) who has at least one child under the age of 18, * (iii) someone in the family is identified as at-risk for substance use exclusion criteria: * the placement of all children in the family in foster care
malaria transmission and immunity in highland kenya

Conditions: Plasmodium Falciparum Malaria

Summary: the purpose of this study is to see why malaria epidemics occur in highland areas in kenya. a better understanding of factors contributing to malaria may be necessary for malaria vaccine planning. these factors include interactions between age, where malaria is passed from mosquitoes to people, immune system (how the body fights infection) responses and other factors that contribute to malaria in epidemic-prone areas. about 6400 people from the villages of kapsisiywa and kipsamoite will participate. study procedures will include in home surveys, which will involve a census and an interview by researchers. blood samples and smears will be collected from some volunteers in both communities to understand how the body protects itself from malaria and to check for malaria parasites. twice each month, random houses will be selected from 3 places in the village to measure the number of mosquitoes in the home. participants may be involved in the study for up to 4 years.

the purpose of this study is to see why malaria epidemics occur in highland areas in kenya. a better understanding of factors contributing to malaria may be necessary for malaria vaccine planning. these factors include interactions between age, where malaria is passed from mosquitoes to people, immune system (how the body fights infection) responses and other factors that contribute to malaria in epidemic-prone areas. about 6400 people from the villages of kapsisiywa and kipsamoite will participate. study procedures will include in home surveys, which will involve a census and an interview by researchers. blood samples and smears will be collected from some volunteers in both communities to understand how the body protects itself from malaria and to check for malaria parasites. twice each month, random houses will be selected from 3 places in the village to measure the number of mosquitoes in the home. participants may be involved in the study for up to 4 years.

Eligibility criteria:
inclusion criteria: active surveillance of clinical malaria -individuals of any age who live in the area (kipsamoite or kapsisiywa) for more than 6 months of the year, or, if they are new to the area, who plan to live in the area for more than 6 months of the year (permanent residents). passive surveillance of clinical malaria -any individual living within the boundaries of the 2 study areas (kipsamoite and kapsisiywa) exclusion criteria: active surveillance of clinical malaria * declining to participate in the study * will be gone from site more than 1 week per month * not available for weekly symptom check or bimonthly blood sample collection passive surveillance of clinical malaria * declining to participate in the study * participation in active surveillance study

Keywords: malaria, plasmodium falciparum, kenya
exploration of predictive markers of neoadjuvant immunotherapy in non-small cell lung cancer

Conditions: Lung Cancer

Summary: neoadjuvant immunotherapy has become the standard perioperative treatment in lung cancer, but its effective predictive biomarkers are lacking. a small cohort reported that homologous recombination deficiency (hrd) can be used as a reliable biomarker to predict the efficacy of neoadjuvant immunotherapy, but the findings need to be validated in larger cohorts. moreover, circulating tumor dna (ctdna) has the potential to predict the therapeutic efficacy of neoadjuvant immunotherapy. this study intends to prospectively collect patients with driver-negative stage ii-iiib nsclc who are scheduled to receive neoadjuvant immunotherapy and surgical resection and verify the value of hrd in predicting the efficacy of neoadjuvant immunotherapy. meanwhile, the blood samples before and after neoadjuvant immunotherapy were collected for high-depth ctdna detection to explore the correlation between the dynamic changes of ctdna and the efficacy and prognosis of neoadjuvant immunotherapy.


Eligibility criteria:
inclusion criteria: * stage ii-iiib nsclc * egfr/alk negative * the subjects voluntarily joined the study, signed informed consent, had good compliance, and cooperated with follow-up exclusion criteria: * a history of other malignancies within the past 5 years * patients with autoimmune disease are not suitable for pd1 monoclonal antibody therapy
safety of an early discharge protocol after sleeve gastrectomy

Conditions: Morbid Obesity; Sleeve Gastrectomy; Early Discharge; Safety Issues

Summary: evaluate the safety and efficacy of an early discharge protocol (23 hours, overnight stay) after scheduled sleeve gastrectomy.

this study aims to demonstrate that a shorter hospital stay after sleeve gastrectomy is as safe and useful as conventional protocol with 48-36 hours of stay. we consider that an adequate patient information and support will facilitate this shorter stay

Eligibility criteria:
inclusion criteria: * patients eligible for sleeve gastrectomy * bmi 35 to 50 * asa i to iii * conventional address close to our hospital * laparoscopic surgery * accompanying person after discharge * availability for a smart phone exclusion criteria: * asa iv * revisional surgery * conversion to laparotomy * icu admission after surgery * insulin dependent diabetes mellitus * surgery finishing after 3 pm

Keywords: bariatric surgery sleeve gastrectomy eras
testing different messaging approaches to increase activation of a healthyfood benefit in adults with diabetes

Conditions: Diabetes; Diet; Incentives; Messaging

Summary: the vitality healthyfood benefit is a three-tiered incentive program designed to encourage healthier food choices amongst members of discovery health's vitality program. once enrolled in the benefit, participating members can receive 10%, 15%, or 25% cash-back on the healthy foods they purchase at selected grocers. and, while overall enrollment in the program is high, there is particular interest in increasing enrollment in the benefit amongst vitality members with diabetes. one presumed barrier to enrollment in the benefit amongst members with diabetes is a misperception of the particular relevance of the benefit and healthier food choices for their personal health. improved messaging regarding the healthyfood benefit and its particular salience for individuals with diabetes may be an effective means of increasing activation of the benefit in this population. the proposed study will be a collaboration between discovery health/vitality and researchers at the perelman school of medicine at the university of pennsylvania. in the proposed rct, vitality members with diabetes will be randomised to different types of messages regarding the healthyfood benefit. the investigators will then compare the effectiveness of these different messaging strategies at increasing activation of the healthyfood benefit amongst vitality members with diabetes.


Eligibility criteria:
inclusion criteria: 1. adults over age 18 2. vitality health members who have not yet enrolled in the vitality healthyfood benefit 3. diagnosis of type 2 diabetes (based on registration for chronic benefits for type 2 diabetes) 4. have registered on to discovery health/vitality website in the past (marker of internet access and availability of email address) exclusion criteria: * anyone who does not meet above criteria