Kornimate/medical-research-clean huggingface dataset:
effects of adding raisins to the american diet on fecal microbiota composition

Conditions: Inflammation

Summary: raisins contain a significant amount of dietary fiber and polyphenolic compounds that represent an important substrate for microbiota fermentation which generates potentially beneficial end products, such as short-chain fatty acids. the mammalian gut contains a phylogenetically as well as functionally diverse microbiota that contributes to host physiology. to date, little is known about how increased raisin intake affects human gut microbiota composition. this research study will assess the effects of adding raisins to the diet of healthy adults on the bacteria from feces of human subjects and resulting self-reported gi symptoms as well as markers of immune function. the hypothesis is that by adding raisins to the diet this will result in changes in gut microbiota. furthermore, the changes in microbiota will largely be beneficial, as evaluated by an increase in butyrate producers and bacteria associated with anti-inflammatory properties.

the research study design is a 14 day international focus on increasing raising intake. participants will be provided with a commercial raisin product for a 14 day period. participants will consume 2 servings/day (84g of raisins). while participants will be told to substitute raisins for other diet ingredients, they will be free to choose what to substitute according to their preferences. participants will keep daily food records and will be told that raisin consumption will be monitored in their fecal samples (qpcr). fecal samples will be collected before the start (day1), during (day5-7) and at the end (day 12-14) of the intervention using a stool collection kit (sigma). participants will complete a gi health questionnaire on a weekly basis to determine tolerance to increased raisin intake.

Eligibility criteria:
inclusion criteria: * good health * no systemic antibiotics during the preceding two months * no medication suppressing immune function * willingness to provide basic demographic as well as medical history data exclusion criteria: * gastric ulcers * inflammatory bowel disease (ibd) or irritable bowel syndrome (ibs) * chronic constipation/diarrhea * body mass index (bmi) \> 30 * dietary restrictions that prevent legume intake * currently on any medication that can affect gi transit time * consumption of \>3 servings/week of raisins before study begins

Keywords: gut microbiota
effects of pioglitazone on stress reactivity and alcohol craving

Conditions: Alcohol Use Disorder

Summary: the purpose of this study is to examine the effects of pioglitazone on stress-induced relapse risk in a laboratory model and to examine the effects of pioglitazone on drinking, stress/anxiety, and alcohol craving in the natural environment


Eligibility criteria:
inclusion criteria: * treatment-seeking individuals diagnosed with alcohol use disorder diagnostic (aud) and statistical manual of mental disorders, 5th edition (dsm-5) * fluent in english * past month excessive alcohol use (\>7 drinks/week for woman, \>14 drinks/week for men, \>3 drinks/occasion for women\>4 drinks/occasion for men) * exhibit baseline measures of either 1) 8-23 on ham-a indicative of mild to moderate anxiety, 2) 14-26 on pss score indicative of moderate stress, or 3) ≥2 on drinking motives questionnaire (dmq-r) questions related to drinking indicating that individuals drink at least "some of the time" to cope * exhibit increased stress reactivity (increased physiological response and/or self-report) at the baseline stress reactivity assessment * females will need to agree to use of barrier methods of contraception due to pioglitazone's effects on plasma concentrations of oral contraceptives exclusion criteria: * exhibit severe scores on the ham-a, pss, or ptsd checklist (pcl-5) - may be enrolled at the discretion of the admitting physician (dr. weaver) * physical dependence on alcohol (ciwaa \> 10) * greater than mild substance use disorder on drugs other than alcohol, nicotine, and marijuana * contraindications for taking pioglitazone * medical conditions (e.g., congestive heart failure, clinically significant edema, clinically significant liver disease, hypoglycemia, diabetes, history of bladder cancer) * contraindicating pioglitazone pharmacotherapy or taking contraindicated medications (e.g., cyp2c8 inhibitors or inducers, antihyperglycemic medications) * be pregnant, nursing, or planning on becoming pregnant during the course of the study * have any other illness, condition, or use of medications, which in the opinion of the pi and/or admitting physician would preclude safe and/or successful completion of the study

Keywords: alcohol pioglitazone stress anxiety
celiac disease database

Conditions: Celiac Disease

Summary: the focus of this study is to create a database containing information about patients with celiac disease. this database will allow us to examine clinical and epidemiologic features of the university of chicago medical center patient population. we have the largest population of patients with celiac disease in the mid-west and as such this study using information gathered from our database can greatly contribute to our current understanding of this disease.

this database will allow us to examine clinical and epidemiologic features of the university of chicago medical center patient population.

Eligibility criteria:
inclusion criteria: * must be a patient at the university of chicago medical center * clinical diagnosis of celiac disease or gluten sensitivity exclusion criteria: * currently being treated at a healthcare facility other than the university of chicago medical center * not diagnosed with celiac disease or gluten sensitivity

Keywords: celiac disease
complication and lung function impairment prediction using perfusion and ct air trapping

Conditions: Non-small Cell Lung Cancer

Summary: the primary objective of the clippcair study is to construct and validate a new algorithm for predicting post-operative forced expiratory volume in 1 second (fev1) values for lung resection candidates; this new model will be based on data derived from a thoracic ct scan with injection of contrast media.

secondarily, the predictions made using traditional scintigraphic data will be compared with those from the new algorithm in a subset of high-risk patients, and cumulative contrast media and irradiation doses associated with imaging will be presented. how other measures of pulmonary function (e.g. transfer factor of the lung for carbon monoxide (tlco)) and the presence/absence of operative complications might be predicted will also be investigated. additionally, the potential links between (i) pre-surgical imaging data, (ii) post-surgical changes in respiratory function, and (iii) changes in health related quality of life will also be explored.

Eligibility criteria:
inclusion criteria: * patient diagnosed with non-small cell lung cancer * indication for pulmonary excision surgery * patient requiring a more recent pre-surgical computed tomography scan (ct scan) * the patient has been correctly informed about the study and has signed the consent form * the patient is affiliated with or a beneficiary of the french single-payer social security programme (national health insurance) exclusion criteria: * patient in an exclusion period determined by another protocol * participation in another study that may affect the results of the present study (anti-cancer treatment studies are allowed) * patient under legal or judicial protection * contraindication to surgery or iodine injection * pregnant or lactating women
clinician access to soldier suicide information (cassi)

Conditions: Suicide

Summary: the overall objective of this project is to conduct a feasibility study using data proved by department of defense national center for telehealth and technology (t2) toward the ultimate goal of establishing a mechanism by which va clinicians could access data on veterans regarding suicidal thoughts and/or behaviors that occurred when they were on active duty, as documented in the department of defense suicide event report (dodser).

as a first step toward the overall goal of this project, the investigators will use data from t2 to conduct the first stage of a feasibility study. specifically, the investigators will attempt to match social security numbers (ssns) of soldiers who have had suicidal thoughts and/or behaviors in the dodser against ssns of veterans seeking mental health services at any va in the united states. once this first step has been accomplished, the investigators also aim to describe the group of veterans with dodsers who are accessing va services (i.e., demographic information, military service variables, and health care utilization variables) in an attempt to better understand this group. it is anticipated that if this study is successful, a next step would be to explore the possibility of dodser data sharing with va partners toward attainment of the following long-term goals: 1. sharing information on history of active duty suicidal thoughts and/or behaviors among discharged individuals seeking mental health services in va systems; 2. facilitating identification of these veterans; 3. reducing va clinician burden though effective access to existing data that may help in assessment and treatment planning; 4. lowering health care costs through effective early management; 5. improving quality of care for veterans seeking services through va outpatient mental health clinics.

Eligibility criteria:
inclusion criteria: * identified with a history of suicidal thoughts and/or behaviors, as recorded in the army dodser exclusion criteria: * death by suicide contained in the army dodser (i.e., this information will not be sent to us by t2)
the impact of pericardial closure on the grafts, in the context of coronary artery bypass grafting

Conditions: Bypass Graft Stenosis

Summary: once the pericardium is closed, there is no information on the hemodynamics of the grafts after coronary artery bypass grafting. this would be the reason for different opinions on pericardial closure: some teams do not close the pericardium and others close it. in the department cardiovascular surgery of the university hospital of saint-etienne, the medistim machine is used in routine and the hemodynamic properties of the grafts are recorded immediately after the bypass surgery, before the closure of the pericardium.

the aim of the study is to have hemodynamic information immediately after the closure of the pericardium using the medistim machine. the prospective study will be conducted on 50 patients, who will be selected consecutively without randomization. the inclusion and exclusion criteria are determined.

Eligibility criteria:
inclusion criteria: * all patients who will have isolated aortocoronary bypass grafting surgery exclusion criteria: * history of thoracic trauma * severe cyphosis * severe thoracic deformity (pectus excavatum) * pericardial disease * history of radiotherapy * severe pulmonary disease (emphysema) * right heart failure * redo surgery

Keywords: cardiac surgery pericardial closure grafts bypass aortocoronary bypass
saliva-based detection of cd44

Conditions: Oral Cavity Squamous Cell Carcinoma; Oropharynx Squamous Cell Carcinoma; Squamous Cell Carcinoma of the Oropharynx; Squamous Cell Carcinoma of the Head and Neck

Summary: the purpose of this study is to test the ability of oncalert™ to screen for cancer and the reappearance of cancer. oncalert™ was developed by vigilant biosciences, a collaborator in this research study. oncalert™ is an oral rinse which is spit into a cup and sent to a laboratory for analysis. oncalert™ is considered experimental by the fda because it is not approved for the screening of cancer.

a noninvasive point of care salivary rinse test performed as 1) a one-time test for control subjects, 2) at pretreatment and post treatment 3,6, 12, and 18 month time points in oral cavity/oropharynx cancer patients

Eligibility criteria:
inclusion criteria: * patient has the ability to understand and the willingness to sign a written informed consent. * previously untreated, measurable squamous cell carcinoma of the oral cavity or oropharynx with no evidence of distant metastasis, t1-4n0-3m0 * no prior history of treated upper aerodigestive tract cancer * no concurrent, second, active malignancy other than oral cavity and/or oropharynx cancer * planned to undergo treatment with curative intent * able to follow up after therapy at 3, 6, 12, and 18 months after completion of therapy during routine post treatment follow up * for control subjects: no evidence or history of upper aerodigestive tract cancer * for control subjects: absence of any suspected or confirmed active malignancy at time of enrollment * patients may have had prior therapy for malignancy other than upper aerodigestive malignancy completed 2 years prior to enrollment if they have been disease free since completion of therapy * patient is ≥ 18 years of age. * both men and women of all races and ethnic groups are eligible for this trial. * performance status ≤ ecog 3 * patient is able to gargle and spit 5 cc of saline * patients may be concurrently enrolled in other therapeutic or detection clinical trials exclusion criteria: * prior completed therapy for an upper aerodigestive tract cancer within the past 3 years. * patient unable to gargle and spit 5 cc of saline, or anticipated to be unable to gargle and spit after completion of therapy * patient unable or does not intend to undergo curative therapy * patient with concurrent, second primary malignancy under active therapy or completed therapy within 2 years prior to enrollment.

Keywords: oral cancer head and neck cancer
investigation of fecal microbiota transplant in chronic intestinal pseudo-obstruction patients

Conditions: Intestinal Pseudo-Obstruction; Fecal Microbiota Transplantation

Summary: chronic intestinal pseudo-obstruction (cipo) is a rare gastrointestinal disorder that primarily affects the movement of the intestines, leading to symptoms that resemble a true bowel obstruction but without a physical blockage. this condition is characterized by impaired motility of the gastrointestinal tract, which can result in severe symptoms and complications. in previous studies, the investigator found that sequential microbiota transplantation therapy can improve clinical symptoms of chronic pseudo-obstruction. building on this foundation, the current study further investigates the effects of sequential interventions involving intestinal cleansing, small intestine bacterial treatment, fecal microbiota transplantation, and nutritional therapy on the short-term and long-term clinical symptom improvement in patients. additionally, the investigator aim to elucidate the changes in gut microbiota phenotypes before and after treatment.


Eligibility criteria:
inclusion criteria: 1. aged over 18 years old; 2. met the current diagnosis criteria for chronic intestinal pseudo-obstruction; 3. can tolerate nasojejunal tube and complete full course of fmt treatment; 4. the clinical data are relatively complete and there is follow-up available for evaluation exclusion criteria: 1. accompanied by chronic wasting diseases such as malignant tumor and hyperthyroidism; 2. associated with gastrointestinal organic diseases such as short bowel syndrome, intestinal fistula, and inflammatory bowel disease; c) severe destruction of the intestinal mucosa, severe immunosuppression, combined with severe systemic infection; d) intervention with antibiotics during treatment
uncomplicated pelvic inflammatory disease. treatment with moxifloxacin.

Conditions: Pelvic Inflammatory Disease

Summary: comparison of various antibiotics in treatment of uncomplicated pelvic inflammatory disease


Eligibility criteria:
inclusion criteria: * diagnosis of pid based on: pelvic discomfort- direct lower abdominal tenderness; * adnexal tenderness on bimanual vaginal examination, * temperature \> 38.0°c; - elevated c-reactive protein value (crp); * signed pic/ic exclusion criteria: * pregnancy * abnormal lab values

Keywords: antibiotic treatment pelvic infection interventional study female
homeopathy assessment in terms of the consumption of analgesics after knee ligamentoplasty

Conditions: Pain

Summary: this is an add-on, double blind, and randomised clinical trial with three groups: a homeopathic group, a placebo group, and a temporal control group. the aim of this trial is to assess the effect of homeopathy on the consumption of morphine delivered by pca (patient control analgesia) for 24 hours after a knee ligamentoplasty.

we test the effectiveness of an homeopathic drug versus placebo and a temporal control group (patient with no add-on treatment) following orthopedic knee surgery. all patients have a pca of morphine for 24 hours after surgery. after this period they can take an oral tablet of morphine on request. group a: patients with study treatment (homeopathy) allocation. double blind group with 70 patients group b: patients with placebo allocation. double blind group with 70 patients group c: temporal control group with patients who take only the morphine. open group with 25 patients the total power: 70 +70 + 25 = 165 patients main objective: * to assess the effect of homeopathy in terms of morphine consumption delivered by pca (patient control analgesia) for 24 hours after a knee ligamentoplasty. secondary objectives: * to assess the effect of homeopathy in terms of total morphine consumption between h24 and h72 after a knee ligamentoplasty. * to assess the effect of homeopathy on the pain perception using a analogical visual scale for 72 hours. * to asses the placebo effect of the homeopathic treatment. main assessment criterion: * morphine consumption delivered by pca between 0 and 24 hours after knee ligamentoplasty secondary assessment criteria: * morphine consumption between 0 and 72 hours after ligamentoplasty * pain assessment at h0, h4, h24 and h72 using 10 cm analogical visual scale inclusion criteria: * age ranging from 18 to 60. * patients candidates for a ligamentoplasty of the anterior cruciate ligament. exclusion criteria: * patient with corticoid and immunodepressor treatment

Eligibility criteria:
inclusion criteria: * age ranging from 18 to 60 years. * patients who are candidates for a ligamentoplasty of the anterior cruciate ligament. exclusion criteria: * patients with corticoid and immunodepressor treatment

Keywords: homeopathy assessment pain ligamentoplasty
vitamin d supplementation in breastfeeding women

Conditions: Vitamin D Deficiency; Rickets; Infant Nutrition Disorders

Summary: adequate vitamin d is essential for proper infant growth and development. however, human milk is low in vitamin d, and most infants do not receive recommended supplementation. our aim is to assess the feasibility of providing adequate vitamin d to breastfed infants through maternal vitamin d supplementation. forty non-pregnant, lactating women at least 18 years of age with exclusively breastfed infants between the ages of 1 and 6 months will be randomized to receive oral vitamin d as either 5,000 iu daily for 28 days or 150,000 iu as a single dose. maternal serum calcium, phosphorus, vitamin d and 25(oh)d; maternal urinary calcium; maternal milk vitamin d and 25(oh)d will be measured on days 0, 1, 3, 7, 14, and 28 of the study; and infant serum vitamin d and 25(oh)d will be measured on days 0 and 28.


Eligibility criteria:
inclusion criteria * currently lactating mothers at least 18 years of age * willing to continue exclusively breastfeeding their infant throughout the study interval * the infant is 1-6 months of age at the beginning of the study * willing and able to participate in all aspects of the study * mother and infant are in good health, as determined by the study investigator * have been provided with, understand, and have signed the informed consent for themselves and their child. exclusion criteria * have recently travelled (within the preceding 30 days) or plan to travel south of 35 degrees north latitude during the study interval * have recently or plan to engage in indoor tanning * are currently taking medications that affect vitamin d metabolism, like steroids, anticonvulsants, or barbiturates * are nursing multiple infants (e.g. twins) * are taking greater than the daily recommended intake of 1000 mg elemental calcium as calcium supplements * are taking greater than the standard daily dose of 400 iu of vitamin d found in prenatal vitamins * infant weight below 1.67 kg * mothers with baseline 25(oh)d levels \>70 ng/ml, and/or infants with baseline 25(oh)d levels \>70 ng/ml * history of kidney stones

Keywords: vitamin d deficiency rickets infant nutrition
personalized crt - psr

Conditions: Heart Failure

Summary: the purpose of this study is to evaluate the cardiac resynchronization therapy (crt) response in a real-world patient population and evaluate options to address non-response and patient management.

the personalized crt study is a multi-center, single arm, prospective observational study. the purpose of the study is to better understand and characterize heart failure (hf) patient management by characterizing the use and clinical benefit of medtronic market-released features/tools within the hf patient management portfolio.

Eligibility criteria:
inclusion criteria: * patient or legally authorized representative provides written authorization and/or consent per institution and geographical requirements * patient has or is intended to receive or be treated with an eligible crt device * patient within 30 days of therapy received at the time of their initial psr platform enrollment exclusion criteria: * patient who is, or is expected to be inaccessible for follow-up * patient with exclusion criteria required by local law * patient is currently enrolled in or plans to enroll in any concurrent drug and/ or device study that may confound results
reducing social avoidance among adolescents with special educational needs

Conditions: Social Avoidant Behavior; Social Anxiety

Summary: the goal of this clinical trial is to examine the effectiveness of a virtual reality (vr) social avoidance intervention in reducing social avoidance symptoms among adolescents with special educational needs. participants will complete tasks in the vr scenario with increasing difficulty and learn that they can cope in situations that they previously avoid. we hypothesize that, comparing with usual care (i.e. waitlist control), the intervention group will experience a significant reduction on social avoidance symptoms after treatment and this benefit will persist till 1-month follow-up.

over the past 25 years, vr has been used to complement therapist-delivered psychological interventions, primarily exposure therapy for anxiety related disorders. vr renders real-world social interactions simulation, which allows users to experience an anxiety provoking situation with a greater sense of control. in hong kong, with the lack of mental health professionals being a perennial problem, vr-based interventions offer the potential to substantially reduce the treatment time and cost, as well as to increase access to evidence-based psychological interventions. the virtual reality (vr) social avoidance intervention used in the current study is designed based on cognitive-behavioral approach with a virtual coach acting as the therapist. it is designed in tandem with input from hong kong users to ensure the scenario can resonate with them.

Eligibility criteria:
inclusion criteria: * age 16-19 * can read traditional chinese and understand cantonese * self-report on experiencing social avoidance symptoms exclusion criteria: * history of photosensitive epilepsy * impairment of stereoscopic vision * balance problems

Keywords: social avoidant behavior adolescents special education needs