Kornimate/medical-research-clean huggingface dataset:
the relationship between body mass index and patient outcomes in low flow anaesthesia

Conditions: Major Gynecological Cancer Surgery; Low Flow Anesthesia

Summary: this study was designed as a prospective observational study.

in this study, it was planned to evaluate the effect of body mass index on patient outcomes during low flow anaesthesia in patients undergoing gynaecological cancer surgery on the specified dates. asa ii and iii patients over 18 years of age were included in the study. low flow anaesthesia is routinely applied in open gynaecological cancer surgeries in our clinic. the relationship between body mass index and intraoperative haemodynamic and mechanical ventilator values and postoperative patient outcomes will be evaluated.

Eligibility criteria:
inclusion criteria: * patients with asa ii-iii * \&gt;18 years * patients undergoing major open surgery for endometrium, cervix or ovarian ca in gynaecological oncology clinic exclusion criteria: * patients who refused to participate in the study * cerebrovascular disease * those with severe pulmonary disease * those with serious cardiovascular disease

Keywords: major gynecological cancer surgery low flow aneshesia cerebral oxygenation hypoxia
retinal vascular manifestations in patients with common internal diseases on octa tomography angiography

Conditions: Hypertension; Diabetes Mellitus; Dyslipidemias

Summary: hypertension, diabetes mellitus, and dyslipidemia are common internal diseases, and all diseases are atherosclerosis risk factors. previous studies applied color fundus photography to analyze retinal vascular changes (including exudation, hemorrhage, neovascularization, etc.) in patients with hypertension or diabetes, but the examination results could not be quantified. this study intends to apply optical coherence tomography angiography (octa) to examine retinal vessels. this method has the following advantages: 1) it can quantify vascular changes, and 2) it is noninvasive and reproducible for patients' follow-up. this study was designed to investigate retinal vascular changes in patients with hypertension, diabetes, and dyslipidemia on octa. we will collect the patients' general information (gender, age), comorbidities, medications, blood lipids, blood glucose, carotid ultrasound, ankle-brachial index, ambulatory blood pressure monitoring, color fundus photography, and octa results. we will follow up with the patients for five years and conduct the mentioned examinations once a year. we will also investigate the correlation between systemic atherosclerosis (such as coronary artery stenosis, and carotid artery stenosis) and retinal vasculopathy in patients with these diseases.

patients with hypertension, diabetes mellitus, or dyslipidemia, who go to the department of geriatric medicine, beijing tongren hospital from march 2022 to december 2023 will be included. we will collect general information, comorbidities, medication, laboratory tests, and examination results. these patients will be followed up for 5 years with a yearly collection of comorbidities, medication, laboratory tests, and examination results.

Eligibility criteria:
inclusion criteria: * patients with hypertension * or patients with diabetes * or patients with dyslipidemia * agree to participate in this study exclusion criteria: * patients with malignant tumors * patients with autoimmune diseases * patients with immunodeficiency disease * disagree to participate in this study

Keywords: octa hypertension diabetes dyslipidemias
the correlation between sleep quality and sleep aid use and dietary patterns

Conditions: Sleep Disorder (Disorder)

Summary: in this study, medical staff in emergency and critical care departments were investigated. it was assumed that the use of sleep aids and dietary patterns affected their sleep quality. the structural equation model was used to analyze the status of sleep quality of medical staff in emergency and critical care departments, and to explore the effects of sleep aids and dietary patterns on sleep quality and its mechanism. ( 1 ) is the overall sleep quality of medical staff in emergency and critical departments poor ( 2 ) do medical staff with poor sleep quality in acute and critical departments use sleep aids more frequently ( 3 ) is there a correlation between sleep quality and certain dietary patterns among medical staff in emergency and critical care departments ( 4 ) are there significant differences in dietary choices among medical staff in emergency and critical departments using sleep aids


Eligibility criteria:
inclusion criteria: ( 1 ) medical staff who have obtained the qualification certificate of doctors and nurses through practice registration. ( 2 ) working in the emergency and critical care departments for more than 1 year ( 3 ) no serious physical disease and psychiatric history. ( 4 ) be able to communicate in chinese exclusion criteria: ( 1 ) interns, students or trainees ( 2 ) the last six consecutive months of sick leave, maternity leave, out of the learner ( 3 ) non-night shift workers

Keywords: sleep quality sleep disorders sedative-hypnotic drugs dietary pattern clinical medical staff
the use of coconut oil for the prevention and treatment of diaper dermatitis in the nicu population

Conditions: Dermatitis, Contact

Summary: the purpose of the study is to examine the safety and effectiveness of the use of coconut oil for the prevention and treatment of diaper dermatitis among nicu babies at genesis medical center, davenport.


Eligibility criteria:
inclusion criteria: 1. babies admitted to the genesis nicu 2. anticipated stay in the nicu is ≥ 48 hours 3. babies wearing diapers 24 hours a day 4. parent willing to sign informed consent for the study 5. parent willing to use the test products in the diaper area during the trial 6. parent willing to not change the type or brand of diaper and wipes during the study 7. parent willing to refrain from changing any other products whose use may have an effect of their baby's skin condition during the trial exclusion criteria: 1. babies with a gestational age \<30 weeks 2. babies with major congenital malformations 3. active dermatological conditions other than diaper dermatitis that may affect trial results 4. known sensitivity to ingredients in trial products 5. babies whose parents have a hazelnut or coconut allergy 6. other severe acute medical conditions that may increase the risk associated with trial participation
an observational study to assess safety and effectiveness of intravenous novorapid® in hospitalised subjects

Conditions: Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2

Summary: this study is conducted in asia. the aim of this observational study is to evaluate the side effects profile and benefits of using intravenous insulin aspart infusion in hospitalised subjects under normal clinical practice conditions in india.


Eligibility criteria:
inclusion criteria: * any hospitalized subject with hyperglycaemia requiring intravenous insulin therapy is eligible for the study based on the discretion of the physician. exclusion criteria: * subjects who are unlikely to comply with protocol, e.g., uncooperative attitude; * subjects with a hypersensitivity to novorapid or to any of the excipients. * subjects with conditions considered as contraindications.
phase i study in healthy volunteers to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of azd4017 after repeated ascending oral doses

Conditions: Diabetes Mellitus Type 2

Summary: the primary aim of this study is to investigate the safety and tolerability of azd4017 when given as multiple oral ascending doses to healthy volunteers. this will be done by comparing the effect of azd4017 to placebo. the study will aslo investigate the absorption, distribution and disappearance of azd4017 in the body. information about plasma concentrations of azd4017 vs time after dose intake will also be collected and some measures of pharmacokinetics versus pharmacodynamics will be included. the future indication for azd4017 is planned to be type 2 diabetes mellitus.


Eligibility criteria:
inclusion criteria: * provision of signed written and dated informed consent * bmi between 19 and 30 kg/m2 * subjects must be willing to use barrier methods of contraception exclusion criteria: * history of any clinically significant disease * any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the first administration of investigational product * history or presence of gastrointestinal, hepatic or renal disease or any other condition known to interfere with absorption, distribution, metabolism or excretion of drugs * laboratory blood sample result showing elevated liver enzymes (asat, alat) and muscle enzymes (ck).

Keywords: safety and tolerability
analgesic effect of low level laser for procedural pain in newborn infants

Conditions: Procedural Pain

Summary: neonates undergo several painful procedures and these pain experiences can alter clinical outcome and behavior. the investigators aim to investigate the analgesic effect of low level laser for procedural pain during heel lancing of term neonates.

this open-label, randomized controlled trial involves 130 term newborn infants (gestational ages between 37 weeks to 42 weeks) who need heel lancing for newborn screening. subjects are randomly assigned to low level laser group or breast milk group. subjects in breast milk group are given 5ml expressed breast milk by mouth using a syringe tube inserted to the participant's oral cavity over a 2-minute period. laserpen is applied to the local point for 20 seconds where heel-lancing will be performed in the low level laser group. then heel lancing is performed and two observers who are blinded to the intervention record the physiological (heart rate and oxygen saturation) and behavioral parameters (duration of crying and modified neonatal facial coding scores) following the procedure. heart rate variation of participants is record by checkmyheart ecg monitor. the salivary swab method is used to detect the infant's salivary cortisol and amylase level as biomarker for stress evaluation. during the study course, digital cameras continuously record participants' behavior. independent t-test, chi-squared test and one way anova are used for statistical analysis.

Eligibility criteria:
inclusion criteria: * healthy fullterm neonates (37-42 gestational age) * apgar score \>= 7 * will receive newborn screening exclusion criteria: * \>42 or \< 37 gestational age * perinatal asphyxia * major malformations or any other disease that need intensive care * drug withdrawal received previous treatment

Keywords: neonates pain low level laser
study of nalbuphine hcl er tablets in hemodialysis patients with uremic pruritus

Conditions: Uremic Pruritus; Pruritus

Summary: the primary objectives of the study to evaluate the effects of two doses of nalbuphine hcl er tablets on the change from baseline in the worst itch numerical rating scale (nrs) in hemodialysis patients with moderate to severe uremic pruritus and to evaluate the safety and tolerability in the study population.


Eligibility criteria:
inclusion criteria: * subject has been receiving in-center hemodialysis for ≥ 3 months and are currently on a schedule of 3 times a week. * subject self-categorized themselves on the patient assessed disease severity scale during screening * subject meets standard of care hemodialysis efficiency guidelines during the three months prior to completing screening * have demonstrated pruritus intensity on the itch nrs during screening * male or female who are at least 18 years old at the time of screening exclusion criteria: * subject had a significant alteration in dialysis regimen during the screening period * subject receiving or anticipated to be receiving nocturnal dialysis or home hemodialysis treatment during the study. * subject has pruritus that is believed to be caused by a condition unrelated to end-stage renal disease * has had a history of substance abuse within 6 months prior to completing screening * subject has a known drug allergy to opioids * subject is a pregnant or lactating female.

Keywords: uremic pruritus itch chronic itch nalbuphine
body mass index and growth parameters evolution in children treated with hybrid closed loop system for type 1 diabetes

Conditions: Diabetes Mellitus, Type 1; Obesity; Overweight; Child Obesity

Summary: overweigth and obesity are commonly diagnosed in children with type 1 diabetes, and frequently an increase of wiegth and bmi is observed after diagnoses. hybrid cloosed loop system are new system where insulin is continually adapted to glycemia (using an algorythme). the weight and growth trajectory of children treated with this system is poorly described.

unlike type 2 diabetes, which is a frequent metabolic complication of obesity, type 1 diabetes is not a consequence of overweight or obesity, or of an excessively sweet or unbalanced diet. however, more and more studies are linking type 1 diabetes to obesity. an international study with 23 026 children suffering from type 1 diabtes has shown that 22.3% of boys and 27.2% of children have overweight, and 6.8% and 6.3% respectively obesity . several hypothesis are made to explain this trend : a consequence of intensive insulinotherapy, the fear of hypoglycemia with unnecessary glucose intake, the increase of caloric intake and the decrease of physcial activity. moreover, subcutaneous insulinotherapy leads to modification in body composition with a increase in fat mass . nevertheless, some studies highlights a possible role of obesity in the type 1 diabetes development( familial history of type 2 diabetes more common in children with type 1 diabetes , inverse relation with age at diagnosis and bmi suggesting that children with higher bmi will be diagnosed early in age . hybrid closed-loop systems, in which the insulin flow rate is adjusted almost instantaneously to the blood glucose level by using an algorithm with a csii and a cgm, are new systems that have gradually been used in current practice . these systems are significantly associated with an improvement in glycemic control (hba1c and tir)\[17\], a reduction in the time spent in hypoglycemic states , and with an improvement in quality of life. nevertheless, the impact of this new treatment on weight evolution has been poorly described. a previous study with 50 children included did not show a bmi modification after 1 year of treatment. individually, some patients following in our center have shown a reduction of bmi after treatment of type 1 diabetes with with hybrid closed loop system. this leads us to perform an observational study in order to describe the trajectory of bmi and growth parameters of children suffering from type 1 diabetes (expressed in standard deviations (sds) after 6 months, 1 year and 2 years of treatment with hybrid closed loop system in the university hospital of nancy. the second objective is to identify potential factors associated with the positive evolution of bmi at 6 months, 1 year and 2 years.

Eligibility criteria:
inclusion criteria: * children between 6 and 18 years at the beginning of treatment with hcl * type 1 diabetes * follow up in university hospital of nancy between 01/01/2021 - 31/12/2023 * treatement with hcl since 6 months exclusion criteria: * parental opposition for the study * pregnancy
effectiveness of ee with vibration versus cryotherapy in rectus abdomini muscle thickness and inter-recti distance

Conditions: Achilles Tendinopathy; Diastasis Recti

Summary: the purpose of this study is to determinate de efectiveness of eccentric exercise combined with vibration or cryotherapy in achilles tendinopathy and its effects on the anterior rectus abdominis muscle. the investigators hypothesis is the combined eccentric exercise with vibration get better results than cryotherapy with eccentric exercise in rectus abdominis muscle parameters.


Eligibility criteria:
inclusion criteria: * sports people * positive initial ultrasound diagnosis * presence of degenerative changes at achilles mid portion * chronic achilles tendon pain, (3/10 vas) * pain when walking or running of achilles tendon, (3/10 vas) * pain in load in plantar flexion of achilles tendon, 3/10 vas) * pain in palpation of achilles, (3/10 vas) * morning stiffness exclusion criteria: * receive physical, orthotic or physiotherapeutic treatment * asociated low back pain, ankle/knee/hip injury that may affect the study * previous injury or surgery of achilles tendon. * pathologies that may limit the joint of ankle * pregnancy * obesity * patients with diabetes and/or other endocrine or metabolic pathologies or neurologic pathologies * patients diagnosed with cardiovascular disease * subjets diagnosed with familiar hypercholesterolemia and/or presence of xanthomas or with hyperuricemia * patients who have received renal transplantation * subjects who have suffered retinal detachment * subjects who have received oral contraceptives, statins, corticoids or hormone replacement therapy in the last six months * subjects who have received treatment wiht fluoroquinolones in the last two years * subjects who have received treatment with aine's in the last four weeks

Keywords: achilles tendinopathy rectus abominis vibration cryotherapy eccentric exercise
hematopoietic stem cell therapy in chronic wounds using a pressure sore model

Conditions: Chronic Wounds; Pressure Sores; Hematopoietic Stem Cells; Wound Healing

Summary: aim of the study: evaluation of feasibility, safety and potential effects of stem cells on chronic wounds using a pressure sore model. clinical relevance: * accelerated healing of uncomplicated wounds * enhanced healing of complicated (chronic, non-healing) wounds study design: * prospective controlled phase i/ii study * cohort of 5 patients in pilot study, then reevaluation patients: - para- and tetraplegic patients with sacral pressure sores grade iii-iva according to the classification of daniel and seiler methods: 1. first surgical intervention: * radical debridement of pressure sore * bone marrow harvest from the iliac crest * isolation of hematopoietic stem cells, aiming to gain \> 1 mio. cd 34+ cells per patient under gmp conditions 3. stem cell therapy (after 2 days) * injection of stem cells in suspension (50'000 cd 34+ cells in 100 microliter saline per cm2 of wound surface) on one half of the total wound surface and cell-free saline on the other half as a control 4. second surgical intervention (after 3-4 weeks): * complete excision of the wound * closure of the defect by fasciocutaneous flap 5. evaluation of wound healing: * clinical * 3d laser imaging * histology * growth factor assay


Eligibility criteria:
inclusion criteria: * para- or tetraplegic * sacral pressure sores * grade iii-iv according to classification of daniel and seiler exclusion criteria: * diabetes mellitus * peripheral vascular disease * coronary artery disease * smoking * steroids and other immunosuppressive drugs * systemic autoimmune or rheumatoid diseases * hiv * hepatitis b/c

Keywords: chronic wounds pressure sores hematopoietic stem cells wound healing
pharyngeal electrical stimulation in amyotrophic lateral sclerosis

Conditions: Amyotrophic Lateral Sclerosis

Summary: during the course of als most patients develop swallowing deficits. in this pilot study we investigate if dysphagia in als can be improved by pharyngeal electrical stimulation (pes). pes is communauté européenne (ce-) certificated and has been approved for treatment of neurological, oropharyngeal dysphagia. during pes, electrical stimuli are applied at the pharynx via a nasogastral tube with the aim of triggering reorganization processes in damaged brain structures. there is evidence of a positive effect of pes in stroke and multiple sclerosis patients.


Eligibility criteria:
inclusion criteria: * possible, probable or definite als according to the revised el escorial criteria (brooks et al. 2000) * age \>18 years * able to understand all information and to give full consent according to good clinical practice (gcp) * moderate ot severe dysphagia, defined by a mean value (all consistencies) of 4 exclusion criteria: * concurrent participation in another interventional trial * tracheostomy * severe psychiatric disorder or clinically manifest dementia * pulmonal or cardial disorder which constitutes a risk when inserting the tube into the pharynx * permanent cardiac pacemaker or defibrillator
investigation of the effectiveness of dynamic neuromuscular stabilization exercises after lumbar disc herniation surgery

Conditions: Low Back Pain; Kinesiophobia

Summary: the aim of the study is to investigate the effects of dynamic neuromuscular stabilization exercises on pain, functionality and fear in individuals who have undergone lumbar disc herniation surgery.

the research was planned as a randomized controlled trial, which is a quantitative study. participants will be divided into 2 groups as control and exercise groups by simple randomization method. the individuals in the control group of the study will not be given any exercise program after surgery. a home exercise program created with dynamic neuromuscular stabilization exercises after surgery will be applied to the individuals in the intervention group. data collection will be carried out through an online survey. the scales and forms to be used before and after the treatment are respectively: 1. oswestry low back pain disability questionnaire 2. international physical activity questionnaire (short form) 3. questionnaire for fear of daily living activities the questionnaires will be uploaded to the google forms database and the participants will be accessed via e-mail or mobile phone applications. . they will be asked to fill out the questionnaires before starting the post-surgical exercise program and the exercise program will be explained practically before discharge. the exercises will be planned 3 times a week and for 8 weeks.

Eligibility criteria:
inclusion criteria: * be between 30 and 50 years old. * having undergone lumbar disc hernia surgery. * having access to a computer/tablet/phone and internet. exclusion criteria: * having cognitive, mental or psychological problems. * having a visual or hearing impairment. * having a physical condition that causes significant loss of function

Keywords: pain neuromuscular stabilization exercises kinesiophobia surgical
breast cancer self-management mobile care application intervention in the quality of life

Conditions: Breast Cancer; Quality of Life

Summary: the aim of this study was to investigate the quality of life (qol) for women with breast cancer in taiwan after using the bcsms app.

after receiving their first diagnosis of breast cancer, women with stage 0 to iii were randomized into intervention and control groups. intervention group subjects used bcsms app and the control group subjects received usual care. two questionnaires: eortc qlq-c30 and eortc qlq-br 23 were distributed to subjects in both arms at baseline and at 1.5 and 3 months. all evaluations were anonymous.

Eligibility criteria:
inclusion criteria: * first diagnosis of breast cancer with stage 0 to iii in past year. * aged 20 to 65 years * had an android/ios smartphone; * able to read and write in chinese; * willing to participate in the study and provide informed consent. exclusion criteria: * not matched to inclusion criteria * mental illness * serious illness and life-threatening

Keywords: breast cancer m-health application self-management life of quality