Kornimate/medical-research-clean huggingface dataset:
retinal function in parkinson's disease

Conditions: Parkinson's Disease

Summary: parkinson's disease (pd) is a neurodegenerative disorder characterized by muscle rigidity, tremor, a slowing of physical movement (bradykinesia) and, in extreme cases, a loss of physical movement. the primary symptoms are the results of decreased stimulation of the motor cortex arising from the basal ganglia normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. secondary symptoms may include high level cognitive dysfunction and subtle language problems. included in the symptomatology experienced by patients with pd, visual abnormalities are not uncommon. visual changes among patients with pd appear not only dynamic in nature, but differentially affected based on the course of the disease and, perhaps more importantly, its treatment. parkinson's disease has significant ramifications not only in observation of irregularities in vision, but how vision interacts with entrainment of the circadian clock. the purpose of this study is to examine the relationship between pd and operation of a unique set of retinal cells known to regulate the circadian clock and sleep-wake cycles in human subjects.


Eligibility criteria:
inclusion criteria: age 18-64 best corrected visual acuity of 20/25 or better in each eye - exclusion criteria: evidence of any form of eye disease, inability to understand and sign informed consent. -

Keywords: retina, parkinson's disease, ganglion cell, pupillary
effect of continuous intra-airway monitoring under visible double-lumen bronchial catheter on postoperative complications of lung surgery

Conditions: Postoperative Pulmonary Complications

Summary: the incidence of postoperative pulmonary complications (ppcs) after thoracic surgery is as high as 30-50% \[1-6\], which is the main cause of postoperative morbidity, death and prolonged hospital stay. optimization of risk factors in ppcs procedures is the focus of current research. double lumen bronchial tube (dlt) is a commonly used lung isolation method for adult patients. it has the advantages of good lung isolation effect, sufficient exposure of the surgical field and easy to attract secretions in the airway. however, there are still some deficiencies in clinical precise positioning, long-term continuous detection during operation, early detection of catheter displacement and other emergencies. continuous intra-airway monitoring is the main advantage of visual double-lumen bronchial catheter. it can quickly and easily determine the position of the catheter and quickly adjust the displacement, and timely and effectively clean up the secretion in the airway, which is conducive to the analysis and treatment of intraoperative hypoxemia. whether these potential advantages can reduce the incidence of ppcs deserves our in-depth discussion. the research group randomly divided the patients who were scheduled to undergo thoracoscopic radical resection of lung cancer in the union hospital affiliated to fujian medical university into the test group (lung isolation with visible double-lumen bronchial catheter, continuous intra-airway monitoring and intervention) and the control group: (pulmonary isolation was performed with visual double-lumen bronchial catheter, and only intra-airway video was performed without monitoring. the effect of continuous intra-airway monitoring under visual double-lumen bronchial catheter on postoperative complications of lung surgery was evaluated by melbourne evaluation scale.


Eligibility criteria:
inclusion criteria: * 1. age 18-80 years, bmi 18.5-28 kg/m2, male or female * 2. patients who are to undergo unilateral thoracoscopic resection of more than three lung segments or lobectomies * 3. patients who can be extubated with 35# and 37# double-lumen bronchial catheters after pre-anesthetic evaluation * 4. subjects voluntarily sign the informed consent form for this trial. * 5. patients or their caregivers are able to fill out the survey form and can correctly understand and cooperate with the postoperative rehabilitation instructions of the medical staff. * 6. patients have spo2 ≥ 96% when inhaling air preoperatively exclusion criteria: * 1. patients with limited ability to cooperate with the study, such as the presence of cognitive dysfunction, mental illness, speech impairment or severe visual impairment or hearing impairment * 2.asa ≥iv * 3. difficult airway, abnormal tracheal development, main airway stenosis, tumor, tracheoesophageal fistula * 4. complex sleeve pneumonectomy, unilateral total pneumonectomy, bilateral lung surgery * 5. preoperative anemia, hb≤100g/l * 6. serum albumin ≤ 35g/l
comparison of the effectiveness of classical perineal massage therapy versus the use of an intravaginal device to reduce postpartum perineal pain

Conditions: Pelvic Pain

Summary: ga34.01 postpartum, a randomized design with a parallel group structure will be applied, randomly assigning participants into two groups. the first group will receive the traditional perineal massage therapy, while the second group will use the intravaginal device "crescendo 2." in this study, a pre- and post-intervention evaluation will be conducted, using the visual analog scale (vas) as the primary outcome measure and the clinical global impression scale as the secondary outcome measure.


Eligibility criteria:
inclusion criteria: * women aged 18 years or older. * residing in the region of murcia. * having had a vaginal delivery between 6 weeks and 12 months prior to enrollment. * presenting postpartum perineal pain, coded in icd-11 as ga34.01. * have not received any prior treatment for this condition. exclusion criteria: * presence of severe conditions such as: * excessive postpartum hemorrhage * serious infections * respiratory or circulatory complications * neurological disorders requiring intensive medical intervention * currently under pharmacological treatment for pelvic pain. * active vaginal infections. * expressed refusal to participate or inability to comply with study procedures. * women with episiotomy may participate only if there were no complications such as severe infection or hemorrhage following the procedure. willingness to participate and to follow the study protocol. exclusion criteria: -

Keywords: postpartum pelvic pain
a study of self-administered misoprostol to prevent bleeding after childbirth in the community (mamamiso)

Conditions: Postpartum Hemorrhage

Summary: postpartum hemorrhage (pph) is a major cause of maternal death in the developing world. an important strategy in the prevention of deaths is the use of uterotonic drugs for pph prophylaxis. misoprostol has been recognized as an option for preventing pph as it is economical, heat stable, has a long shelf-life, and can be taken orally. the investigators envisage that the use of self administered misoprostol after home births among mothers would be associated with a peri-partum fall in hemoglobin value of over 20% (the outcome of a fall of 2g/dl will also be tested in the pilot). the objective of the main study will be to assess the effectiveness and safety of antenatal administration of misoprostol tablets (600mcg) for self administration immediately following home delivery for the prevention of postpartum haemorrhage. the objectives of the pilot study are to test the integrity of the study protocol, to test the randomization procedure, to assess the acceptability of the intervention, to test the logistics of follow-up, to test the data collection forms, to validate the quality of life questionnaire in this population and to determine the recruitment rate to help study planning.


Eligibility criteria:
inclusion criteria: * pregnant women living in the recruitment villages of mbale district at \>34 weeks gestation exclusion criteria: * any woman with a known allergy to misoprostol or other prostaglandins will be excluded as will any woman under 18 years old (unless she is an emancipated minor)

Keywords: postpartum hemorrhage, pph, misoprostol
diastolic ventricular interaction and the effects of biventricular pacing in hypertrophic cardiomyopathy

Conditions: Hypertrophic Cardiomyopathy

Summary: the primary aim of this study will be to assess whether biventricular pacing improves exercise capacity, and quality of life in patients with symptomatic drug resistant non-obstructive hypertrophic cardiomyopathy, using a biventricular pacemaker.


Eligibility criteria:
inclusion criteria: * symptomatic hypertrophic cardiomyopathy, exclusion criteria: * rhythm other than normal sinus left ventricular outflow tract gradient greater than 30mmhg inability to exercise v02 max greater than 70% of predicted.
home enteral nutrition in malnourished patients with gastrointestinal cancer

Conditions: Malnutrition; Gastrointestinal Cancer

Summary: phase iii, medical, multicentric, controlled, open label, two-parallel groups, randomized, clinical trial. the aim of this study is to evaluate the efficacy of home enteral nutrition on the nutritional status, the quality of life and tolerance to chemotherapy, in malnourished patients who undergo major gastrointestinal surgery for malignancy (oesophagus, stomach, pancreas, biliary tract). patients were randomized to receive either home enteral nutrition (hen, treatment group) or nutritional counselling (control group).


Eligibility criteria:
inclusion criteria: * both gender with age higher than 18 years. * documented cancer of the gastrointestinal tract: oesophagus, stomach, pancreas, biliary tract * candidate for major elective surgery. * preoperative nutritional risk score ≥ 3 * written informed consent. exclusion criteria: * age \< 18 years * karnofsky index \< 60 * renal insufficiency (ongoing haemodialysis or plasma creatinine \> 3 mg/dl) * respiratory insufficiency * child-pugh class c * short bowel syndrome * pregnancy * emergency operation * foreign residence or residence in italian region with no regulation designed for home artificial nutrition
project relate: romantic relationship competence ssi

Conditions: Relational Problems; Depression

Summary: the covid-19 pandemic has increased social isolation and depressive symptoms in youth, adding strain to an already overwhelmed mental healthcare system. online single-session interventions are digital programs that can help expand access to care and teach evidence-based skills. to help youth build healthy relationships, we developed 3 online single-session interventions (ssi) to teach romantic competence skills to adolescents and emerging adults. youth, ages 16-20, will be recruited to social media and randomly assigned to one of two conditions: the intervention condition, offering them three ssis to select from, or an information-only control group. within the intervention condition, youth will complete one of three romantic competence ssis: (1) insight, targeting awareness of one's needs in relationships, (2) communication, teaching listening and communication skills, and (3) stay vs. go, helping youth make difficult decisions. investigators will assess each ssi's relative benefits on relationship knowledge and depressive symptoms up to three months later compared to the information-only control group. results will reveal if online ssis can teach romantic competence skills and if engaging in these interventions has psychosocial benefits for youth with elevated depressive symptoms.


Eligibility criteria:
inclusion criteria: * are fluent in english * have consistent internet and computer/laptop/smartphone access * report elevated depressive symptoms (a score of \>2 on the patient health questionnaire-2 item version \[phq-2\]) exclusion criteria: * fail to meet the above-listed inclusion criteria * exit the study prior to condition randomization * respond with either copy/pasted responses from text earlier in the intervention to any of free response questions * obvious lack of english fluency in open response questions * responding with random text in open response questions * duplicate responses from the same individual in baseline or follow-up surveys
efficacy and safety of early tips (transjugular intrahepatic portosystemic shunts) in the management of cirrhosis with recurrent ascites.

Conditions: Liver Cirrhoses

Summary: all consecutive patients with cirrhosis of liver who satisfy the criteria will be included and will be evaluated clinically along with all routine investigations and standard medical therapy will be continued among these patients. the patients between 18-60 yrs of age (cirrhosis diagnosed on the basis of clinical, biochemical, fibroscan \& imaging.) , with ascites and hvpg (hepatic venous pressure gradient) \>12, with 2 or more large volume paracentesis in last 3 month . ctp ≥ 7-13 will be considered for the study. at baseline, a complete history of the cause of cirrhosis of liver with clinical and physical examination, a record of demographic profile, standard of care biochemical investigations would be done. in this study patients who satisfy the inclusion and exclusion criteria as mentioned below will be enrolled to receive either standard medical therapy with large volume paracentesis and albumin infusion or to be randomised to receive tips (transjugular intrahepatic portosystemic shunt). the patients in group a will be given standard medical therapy only included as per requirement nutritional therapy (high calorie intake- 2400 kcal/ day) as and when required large volume paracentesis (lvp) and albumin infusion and diuretics.


Eligibility criteria:
inclusion criteria: 1. liver cirrhotics between 18-60 yrs of age (cirrhosis diagnosed on the basis of clinical, biochemical, fibroscan \& imaging) 2. recurrent ascites (2 or more large volume paracentesis in last 3 month) on maximal tolerated diuretic dose. 3. diuretic intractable ascites ( developing aki/ hyponatremia (na-\ 5.5), who will respond to withdrawal of diuretics 4. hvpg \>12 mm hg 5. ctp ≥ 7-12 6. patient is willing and able to comply with all study protocol requirements, including specified follow-up and testing. exclusion criteria: 1. hepatic or extra hepatic malignancy-hcc, pvt 2. meld (model for end stage liver disease) \> 18 3. post tips (transjugular intrahepatic portosystemic shunt), shunt surgery 4. lvp (large volume paracentesis) \>3/month 5. acute kidney injury (sr.cr\>2mg/dl) 5) ckd (chronic kidney injury) 6) previous hepatic encephalopathy 7) acute on chronic liver failure 8) active infection 9) active alcohol intake 10) left ventricular systolic dysfunction/ overt ccm 11) pph (portopulmonary hypertension) 12) pt on mechanical ventilation 13) patient in icu/ any acute illness 14) pregnant lady 15) sbp (spontaneous bacterial peritonitis)
walk-training program for individuals with chronic spinal cord injury (sci)

Conditions: Spinal Cord Injury

Summary: cardiovascular disease (cvd) is the common leading cause of death among people with spinal cord injury (sci) and occurs at an early age in people with sci as compared to able-bodied people. the findings are consistent in demonstrating a high prevalence of cvd among people with sci. lack of physical activity and/or prolonged sitting which is observed in people with sci due to impaired/loss of motor function is associated with increased risk factors of cvd. by doing this study, researchers hope to learn the effects of walking training on cardiovascular health among people with chronic sci.


Eligibility criteria:
inclusion criteria: * individuals between 18 and 60 years old, who have paraplegia (t1-l2) sci, and who are scored less than 5 in functional independence measure, locomotion: walk * the onset of sci must be one year or more at the beginning of the study * participants must not be participating in any other similar gait training activities * participants must have medical approval from their physician to participate in walk-training exclusion criteria: * major cardiovascular diseases * other neurological diseases * muscle spasticity (greater than 3 according to ashworth scale) * severe orthopedic issues such as joint stiffness and fractures * osteoporosis (bone mineral density t-score less than - 2.5)\[155\] * inflammatory diseases or infections * open wound and pressure ulcer * pregnant women * cognitive or psychiatric disorders * uncontrolled autonomic dysreflexia; sudden increase in blood pressure

Keywords: cardiovascular health walking training
the effect of prescription medications in marijuana users

Conditions: Marijuana Abuse

Summary: a subset of heavy marijuana users have trouble quitting marijuana use and the number of those seeking treatment for problems related to marijuana is increasing. the purpose of this research study is to investigate whether dronabinol can reduce withdrawal effects associated with stopping marijuana use, if dronabinol can reduce the rewarding effects of smoked marijuana, and whether there are any cognitive performance deficits associated with dronabinol doses that produce such effects.


Eligibility criteria:
inclusion criteria: * current use of marijuana * able to give informed consent exclusion criteria: * dependence on drug other than marijuana * pregnant, breast feeding, or planning to become pregnant within the next 3 months * currently seeking treatment for cannabis-related problems or otherwise trying to reduce use * use of cannabis under the guidance of a physician for a medical disorder * unstable or uncontrolled cardiovascular disease (e.g., hypertension, angina) * allergy to study medication

Keywords: withdrawal acute effects cognitive performance marijuana use marijuana abstinence
effects of aerobic exercise on arteriovenous fistula

Conditions: Chronic Kidney Diseases

Summary: arteriovenous fistula (avf) is considered the gold standard for safe and effective vascular access during hemodialytic treatment. it is known that systemic aerobic exercise is capable of promoting peripheral vasodilation, however, its effects on avf are unknown. for this reason, we will evaluate the effects of aerobic exercise on a stationary bicycle over the avf caliber.

hemodialysis is a method responsible for filtering blood and helping to control excess blood fluid and impurities in patients with end-stage chronic kidney disease. the vascular accesses commonly used in this procedure is atribute catheter, which is placed in a large caliber vein, usually jugular or femoral vein, and arteriovenous fistula (avf). in order to use the avf in the hemodialysis procedure, a maturation process of the avf is necessary, characterized by the increase of its caliber, which is accelerated by force exercises located in the avf region, whose purpose is to promote the vasodilation of the avf. systemically performed aerobic exercises are also capable of promoting peripheral vasodilation and their effects on avf are still unknown. therefore, this study proposes to evaluate the behavior of the avf through ultrasound before, during and after performing aerobic exercise on a stationary bicycle. for this, all patient will sign the informed consent form, respond to the international physical activity questionnaire (ipaq) and questionnaire kidney disease quality of life (kdqol-sftm), and use a pedometer for 7 days to measure the number of steps per day to characterize the sample. patients will remain in supine position for 5 minutes to measure their vascular caliber of the avf by echography. after, will be instructed to perform 30 minutes on stationary bike (model monark). the avf vascular caliber will be measured during aerobic exercise. because it is a cross-over trial, participants will perform the other arm after 7 days.

Eligibility criteria:
inclusion criteria: * patients who use avf hemodialysis for at least 1 month. * patients on hemodialysis 3 times a week at the hcpa nephrology service. * age equal to or greater than 18 years. * physical conditions to perform exercises proposed in this study. * stability of chronic kidney disease for at least 30 days, defined by absence of hospitalization. exclusion criteria: * acute myocardial infarction in the last 3 months. * acute infectious or inflammatory process. * decompensated coronary artery disease. * symptomatic peripheral arterial disease. * arteriovenous fistula in lower limbs.

Keywords: exercise vasodilation
efficacy and safety of 9mw0813 in subjects with diabetic macular edema

Conditions: Diabetic Macular Edema

Summary: phase iii clinical study of the efficacy and safety of 9mw0813 and aflibercept (eylea®) in patients with diabetic macular edema (dme) in a multicenter, randomized, double-blind, parallel active-controlled study.

this is a multi-center, randomized, double-blind, parallel controlled phase 3 clinical trial. the primary objective is to compare the similarity of clinical efficacy of intravitreal 9mw0813 injection and aflibercept intraocular injection (eylea®) in dme patients. the secondary objectives are to compare the similarity of safety, immunogenicity and pharmacokinetics of intravitreal 9mw0813 injection and aflibercept intraocular injection (eylea®) in dme patients.

Eligibility criteria:
main inclusion criteria: 1. age ≥ 18 years old, gender is not limited; 2. diagnosed with type 1 or type 2 diabetes, and hba1c≤10.0%; 3. the visual impairment of the study eye was mainly caused by diabetic macular edema; 4. oct examination at screening and baseline, diabetic macular edema involving the fovea of the study eye, and central retinal thickness (crt) ≥ 300 μm (using sd-oct); 5. the best-corrected visual acuity (bcva) of the study eye at screening and baseline measured using the early treatment of diabetic retinopathy study (etdrs) chart was between 73 and 24 letters (inclusive) (approximately equivalent to snellen's visual acuity) score 20/40 to 20/320). main exclusion criteria: 1. active proliferative diabetic retinopathy (pdr) exists in the study eye; 2. structural damage to the fovea in the study eye, which may not improve bcva after resolution of macular edema (eg, retinal pigment epithelial cell atrophy, subretinal fibrosis or scarring, significant macular ischemia, or organizing hard exudates) ); 3. the study eye has any ocular disease or past medical history other than diabetic macular edema, and the investigator believes that it may affect the macular assessment or central vision (such as: cataract, retinal vascular occlusion, retinal detachment, macular traction, macular epiretinal membrane , macular hole, macular hemorrhage, preretinal fibrous proliferation involving the macula, various choroidal neovascularization); 4. the study eye has erythema of the iris, vitreous hemorrhage or traction retinal detachment; 5. the study eye has poorly controlled glaucoma (defined as intraocular pressure ≥25mmhg after anti-glaucoma drug treatment); 6. the study eye has received or may have received glaucoma filtration surgery (such as: trabeculectomy, sclerectomy and non-penetrating trabecular surgery) during the study period; 7. the study eye has received vitreoretinal surgery in the past; 8. aphakic (except intraocular lens) in the research eye.

Keywords: aflibercept biosimilarity