Kornimate/medical-research-clean huggingface dataset:
combination chemotherapy in patients with advanced or recurrent mycosis fungoides

Conditions: Lymphoma

Summary: rationale: drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. combining more than one drug may kill more tumor cells. purpose: phase ii trial to study the effectiveness of etoposide with or without doxorubicin and methotrexate in treating patients who have mycosis fungoides.

objectives: i. assess the response rate in patients with stage iii/iv or recurrent mycosis fungoides or sezary syndrome treated with oral etoposide, with the addition of doxorubicin, then methotrexate for poor responders. ii. assess changes in the hematologic and immunologic status of the tumor in these patients. outline: patients are treated sequentially on regimens a, b, and c depending on response. the following acronyms are used: cf leucovorin calcium, nsc-3590 dox doxorubicin, nsc-123127 mtx methotrexate, nsc-740 vp-16 etoposide, nsc-141540 regimen a: single-agent chemotherapy. vp-16. regimen b: 2-drug combination chemotherapy. vp-16/dox. regimen c: 3-drug combination chemotherapy. vp-16/dox/mtx. projected accrual: study duration will be at least 3 years with an anticipated accrual of 3 patients/year.

Eligibility criteria:
disease characteristics: stage iii/iv mycosis fungoides or sezary syndrome stage i/ii cutaneous t-cell lymphoma in relapse following interferon therapy also eligible patient characteristics: age: not specified prior concurrent therapy: biologic therapy: prior interferon alpha for stage i/ii disease allowed chemotherapy: prior isotretinoin for stage i/ii disease allowed endocrine therapy: prior topical steroids for stage i/ii disease allowed radiotherapy: prior ultraviolet therapy for stage i/ii disease allowed prior x-ray therapy for stage i/ii disease allowed surgery: not specified

Keywords: stage iii cutaneous t-cell non-hodgkin lymphoma stage iv cutaneous t-cell non-hodgkin lymphoma recurrent cutaneous t-cell non-hodgkin lymphoma
management of fracture ankle in adults with uncontrolled diabetes by hind foot nail with versus without joint preparation , in assiut university hospital

Conditions: Figure Out the Best Method of Fixation for Management of Patients With Diabetic Fracture Ankle

Summary: diabetes is a well-known risk factor for complications following ankle fracture fixation.current recommendations for operative treatment of ankle fractures in patients with diabetes consist of increased rigid fixation and prolonged periods of non-weight bearing with minimally invasive techniques. yee et al described a treatment algorithm for ankle fractures in diabetes patients based on the extent of their diabetic complications, adelaide fracture in the diabetic ankle (afda) score, and suggest that primary ankle arthrodesis may be an option in severe situations. ebaugh et.al. described the technique of fixing the ankle joint in diabetic patients without joint preparation . primary hindfoot arthrodesis with calcaneotibial nail with formal joint preparation was described by many authors as treatment for ankle fractures in diabetic patient . to our knowledge, there is no comparative study in management of ankle fractures in diabetic patients using these two different techniques. our hypothesis is to try to prove that management of diabetic fracture ankle by hindfoot nail without joint preparation is better than other techniques regarding overall lower complication rate, higher functional outcome and better option for treatment of these patients using minimal invasive approaches in those high risk patients.


Eligibility criteria:
inclusion criteria: * • all subjects aged 50y or more with recent fracture ankle (less than two weeks) with uncontrolled diabetes in form of high level of hemoglobina1c ( \>6.4% ) and/ or high random blood sugar level on admission (\>200mg/dl). patients with one or more complications due to diabetic e,g. neuropathy, nephropathy , and/or peripheral vascular disease. exclusion criteria: * • previous ankle fracture fixation in the same side. * charcot arthropathy * polytrauma, multiple skeletal injury.
application of sers technology based intraoperative navigation system in lung cancer

Conditions: Lung Cancer

Summary: this study aims to explore the application of surface-enhanced raman scatting (sers) technology in lung cancer surgery and clarify its mechanism through multi-omics mass spectrometry platform, and then further prove the clinical transformation value of this technology.

this study intends to apply the intraoperative navigation system based on surface-enhanced raman scatting (sers) technology to detect the ph of lung tissue, and to evaluate the benign and malignant resection margins of lung tissue based on this. in order to clarify the discrimination mechanism, a multi-omics mass spectrometry platform is planned to study the internal small molecules and pathway changes. in addition, the patients were followed up for five years to explore the correlation between the prognosis of patients and the ph of lung tissues and lymph nodes, which could prove the clinical transformation value of this technology.

Eligibility criteria:
inclusion criteria: 1. voluntary participation in clinical research; fully understand and informed the study and sign the informed consent form (icf); be willing to follow and be able to complete all trial procedures. 2. male or female aged 18-75 years or more when signing icf. 3. extended tumor resection was performed to remove the lung tumor tissue, and the resection margin was ≥2cm from the tumor margin. 4. the effective measured diameter of all the lung tissues to be measured was greater than 0.5cm. 5. the patient had not received previous systemic therapy for cancer. exclusion criteria: 1. unresectable lung cancer patients. 2. patients had received previous systemic therapy for lung cancer. 3. patients with other active malignant tumors within the past year or at the same time. 4. the patient had a known history of psychotropic drug abuse or drug use; she had a history of alcohol abuse. 5. according to the investigator's judgment, the patient had other factors that may lead to the early termination of the study.

Keywords: surgical margin ph prognosis mass-spectrometry surface-enhanced raman scatting (sers)
office hysteroscopy in secondary infertility after cesarean section

Conditions: Infertility, Female

Summary: all women with history of secondary infertility after caesarean section will be subjected to office hysteroscopy according to royal college of obstetrics and gynecology guidelines to diagnose any subtle uterine abnormalities not detected by conventional means. hysteroscopic examination will be done during the proliferation phase of the menstrual cycle. the hysteroscopic evaluation will include assessment of the cervical canal, intrauterine lesions, the endometrium and the uterotubal junction. . if hysteroscopy reveal a lesion, its type, size, location will be recorded. transvaginal ultrasound will be done after the procedure to detect fluid in the douglas pouch to confirm patent tubes. asses the uterine scar in details.


Eligibility criteria:
inclusion criteria: * patients with secondary infertility more than 2 years after cesarean section. * normal semen analysis * normal hysterosalpingography or laparoscopy within 1year * evidence of ovulation by transvaginal ultrasound exclusion criteria: * • cases with abnormal semen parameters. * patients with abnormal hysterosalpingography. * patients with anovulation. * hormonal disturbances; high level of prolactin, thyroid hormone disturbances, very high or very low follicular stimulating hormone and luteinizing hormone * patients known to be epileptic or with history of fits. * cardiac patients ( valve diseases, ischemic, arrhythmic)
observing physiological changes in patients with long-term oxygen therapy

Conditions: Chronic Respiratory Disease

Summary: in this project, the investigators aim to assess changes of physiological parameters obtained non-invasively through ppg and accelerometry signals between before and during ltot (long-term oxygen therapy) and investigate if those changes are different in patients with worsening frailty and/or improving quality of life. for this, they will record optical (ppg) and accelerometry data via a datalogger on 40 patients undergoing ltot and assess the ppg-derived physiological signals.


Eligibility criteria:
inclusion criteria: * age ≥ 18-year-old, and * chronic respiratory disease including a) chronic obstructive pulmonary disease, b) interstitial lung disease, c) pulmonary hypertension, d) bronchiectasis, and * prescribed new ltot due to a chronic respiratory disease with resting and/or exertional hypoxemia, and * able to speak/read/understand german or french, and * willing and able to understand and provide signed informed consent exclusion criteria: * pregnant or lactating women, or * inability to follow the procedures/instructions of the study (e.g. due to language, psychological disorders, dementia, etc.), or * patients having a subordination link to the investigators, or * patients with isolated nocturnal oxygen therapy or ltot prescription for a heart disease, sleep associated breathing disorder, neuromuscular disease or lung cancer, or * known participation in another human research project (clino/hro) that may affect the objectives of this study.
amplitude and rate of intrinsic feedback during treadmill training for parkinson's disease

Conditions: Parkinson's Disease; Treadmill

Summary: treadmill training has been shown to be beneficial for reducing motor symptoms of parkinson's disease (pd). the mechanisms for the therapeutic effects of treadmill training remain unknown. however, specific types of intrinsic feedback generated from muscle spindles (detect changes in length of muscle) and golgi tendon organs (detect muscle force) seem to be an important factor for achieving the reductions in motor scores. this study will compare a treadmill program that generates a high rate of intrinsic feedback to a treadmill program focused on generating a high magnitude of intrinsic feedback.


Eligibility criteria:
inclusion criteria: * diagnosis of parkinson's disease * must be able to walk unassisted for 10 metres exclusion criteria: * cardiovascular disease/history of stroke * dementia * lower body injury that would be worsened by repetitive walking

Keywords: treadmill parkinson's proprioception cadence step length intrinsic feedback
assessment of two methods for progesterone dosage during ivf

Conditions: Infertility

Summary: nowadays, 1/7 couple consult because of infertility and some of them will need in vitro fertilization +/- intracytoplasmic sperm injection (ivf+/- icsi). the ivf process includes a 14 days stimulation with fsh +/- lh in an agonist or antagonist protocol. the monitoring consists of regular ultrasound scan and blood sample. during the stimulation protocol many test have been proposed to predict the success of ivf. however, progesterone dosage on triggering day seems to be the only relevant exam. indeed, when the progesterone blood concentration is low, the pregnancy rate is decreased. the only way to obtain progesterone concentration is a blood sample. the ivf journey is known to be stressful with many injections. therefore, the salivary dosage appear to be more patient friendly. this kind of dosage has already been studied yet never use in routine because of a lack of repeatability. the laboratory of lyon has developed a new technique to overcome this issue by using a liquid chromatography-mass spectrometry. the aim of this work is as a first step to assess the repeatability, reliability and precision of salivary dosage on triggering day for ivf patient compared to blood concentration of progesterone.


Eligibility criteria:
inclusion criteria: * adult patients between 18 and under 43 years old * in the course of ivf more or less icsi of the pma service of the hfme with transfer of fresh embryo * signature of an express consent * understanding the french language, both oral and written. * affiliated to a social security scheme exclusion criteria: * persons deprived of their liberty by a judicial or administrative decision * persons subject to psychiatric care * persons admitted to a health or social establishment for purposes other than research * participants in another study that could impact the results of the present study, in particular those related to the level of progesterone. * adults subject to a legal protection measure (guardianship, curatorship)

Keywords: progesterone concentration salivary test in vitro fertilization infertility
post intensive care syndrome

Conditions: Post Intensive Care Syndrome; Barthel Index

Summary: barthel index and demographic variables of patients were collected to investigate the question whether the improvements of the functionality improves the barthel index over the years.

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Eligibility criteria:
inclusion criteria: * 18 years and older * length of stay longer than 48 hours exclusion criteria: * no exclusion criteria if inclusion is correct

Keywords: intensive care functionality
treatment of anemia and neutropenia in hiv/hcv coinfected patients treated with pegylated interferon and ribavirin

Conditions: Anemia; Neutropenia; Hepatitis C Virus; HIV Infections

Summary: this study is designed to test two separate strategies for treatment of anemia (low hemoglobin) and neutropenia (low white blood cells) in hiv/hcv coinfected patients who are being treated with pegylated interferon and ribavirin.

this is a multi-center, randomized, open-labeled trial in subjects co-infected with hepatitis c (hcv) and human immunodeficiency virus type 1 (hiv-1) who are naïve to anti-hcv therapy. subjects will receive peg interferon alfa-2b (peg-ifn) 1.5 mcg/kg/week administered once weekly plus ribavirin (rbv) 13 + 2 mg/kg/day. the goal of this study is to evaluate two different treatment options for anemia and neutropenia associated with the initiation of pegylated interferon and ribavirin. this will result in completion of therapy, and possibly a better viral sustained response.

Eligibility criteria:
inclusion criteria: * hemoglobin \> 11 * absolute neutrophil count \>1,200 * naive to peg interferon and ribavirin exclusion criteria: * prior treatment for hepatitis c * pregnant or nursing

Keywords: anemia dose reduction neutropenia hepatitis c virus human immunodeficiency virus
post-market assessment of biodesign dural repair grafts

Conditions: Cerebrospinal Fluid Leak

Summary: the purpose of this clinical study is to gather post-market clinical evidence on the use of the biodesign® dural and duraplasty grafts when used as a dura substitute of the dura mater.


Eligibility criteria:
inclusion criteria: 1. planned use of the biodesign dural or duraplasty graft. exclusion criteria: 1. age \<18 years 2. unable or unwilling to provide informed consent 3. life expectancy \<6 months

Keywords: dura mater repair cerebrospinal fluid leak csf leak biodesign® dural repair graft biodesign® duraplasty repair graft
electroacupuncture with or without combined warm needling for tinnitus

Conditions: Tinnitus; Tinnitus, Subjective

Summary: this randomized controlled trial aims to evaluate the efficacy and safety of either electroacupuncture alone or combined with warm needling in reducing tinnitus loudness and improving the impairment caused by tinnitus in hong kong.

this study is a prospective, multicenter, assessor-blind, three-arm, parallel-group, randomized waitlist-controlled trial. a total of 90 eligible subjects with tinnitus will be recruited and randomly assigned to electroacupuncture (ea), electroacupuncture combined with warm needling (eawn) or waitlist control with n=30 subjects each group. the entire study period will last for 10 weeks, including a 5-week intervention period and a 5-week follow-up period. outcome measures include the loudness of tinnitus and the tinnitus handicap inventory. any adverse event will be observed and recorded for safety assessment. the study findings will provide evidence to determine the efficacy and safety of electroacupuncture with or without combined warm needling for tinnitus in hong kong.

Eligibility criteria:
inclusion criteria: * diagnosed with subjective tinnitus; * male and female, age 50 to 70 years old; * unilateral or bilateral tinnitus for 0.5-24 months; * loudness of tinnitus rated 3 points or more on a 0-10 numeric rating scale (nrs) at the time of enrollment; and * agree to sign the informed consent form voluntarily. exclusion criteria: * known disease conditions that could cause tinnitus such as meniere's syndrome, acoustic duct diseases, and middle ear diseases; * history of head trauma; * currently using cardiac pacemaker or metal implants; * known severe cardiac diseases, cerebrovascular diseases, renal diseases, or hematologic diseases; * known severe psychiatric or psychological disorder; * pregnant, lactation or expecting a pregnancy during the study period; * severe needle phobia; * known hypersensitive reaction after acupuncture and moxibustion treatment or an inability to cooperate with the acupuncture and moxibustion procedure; * incapable to understand and answer the questions of the assessors in the study; and * other factors deemed unsuitable for inclusion in the study by investigators.

Keywords: tinnitus acupuncture moxibustion warm needling clinical trial randomized controlled trial
pilonidal sinus disease: preliminare study

Conditions: Pilonidal Sinus

Summary: pilonidal disease is morbid condition of young productive population, that could impair quality of life with high cost for health care system. no consensus exists on optimal surgical treatment, even if several techniques have been proposed. in this preliminary experimental case-control study the investigators compared excision by knife and diathermy with the aim to investigate if wound dehiscence could be related to heat spreading during excision of the sinus.

between january 2017 and february 2018, 29 patients underwent to sinus excision. the investigators considered 16 sinus excision performed by diathermy as a case group (named "hot" group) and the last 13 procedures performed by knife as control group (named "cold" group). temperature data were recorded for both group. follow-up was carried out until complete healing. were considered primary and secondary outcomes.

Eligibility criteria:
inclusion criteria: * male and female patients between 14 and 65 years old, * primary, non recurrent pilonidal disease * midline and intergluteal location * spinal anesthesia * dimension no more than 5 cm in length, primary closure performed exclusion criteria: * age \ 65 years old, * secondary fistulous tracts or lateral developing/cutaneous opening * dimension over 5 cm in length, * local anesthesia employ * smoker and obese patients (bmi\> 25 kg/m2) * diabetic and coagulopathies affected one * flogged or acute or infected or abscessed forms * asa score \> iv, * normal range wbc and hb preoperative values.

Keywords: pilonidal sinus disease wound deiscence
comparison between two optional ivc filters regardind ease of use,complications and outcome

Conditions: Trauma; Deep Vein Thrombosis

Summary: optease filters are easier to retrieve but the dwell time is shorter than the gunter filters. there are more thrombi on the optease than on the gunter at the time of retrieval. optease filter has a better infitration capabillity due to its diamond shape. optease filters will hjave more ivc occlusions as a complication.

we will isert the two filters blindly. we will follow the patients clinically and if needed we will add imaging exams. we will try to retrieve most filters.

Eligibility criteria:
inclusion criteria: * all patients referred for filter insertion exclusion criteria: * young age (\<18 years)

Keywords: ivc filters trauma dwell time
investigation of the effectiveness of connective tissue massage in individuals with erectile dysfunction symptoms

Conditions: Erectile Dysfunction

Summary: in this study, it is planned to investigate the effect of connective tissue massage on symptom severity, autonomic functions, psychological state and quality of life in individuals with erectile dysfunction symptoms.

the most common sexual dysfunctions in men include erectile dysfunction and premature ejaculation. erectile dysfunction (ed) is defined as the inability to achieve and maintain the penile erection necessary for sexual intercourse for at least 6 months.the prevalence of ed generally varies between 37.2%-48.6%. there are various treatment methods used in individuals with ed symptoms. while urologists use oral phosphodiesterase-5 inhibitor drugs (such as sildenafil and vardenafil) as the first step, intracavernosal papaverine or alprostadil injections and vacuum devices may be preferred afterwards. when these treatments are inadequate, penile prostheses can be used. in addition, various physiotherapy techniques such as pelvic floor muscle training, electrical stimulation, massage and aerobic exercises are also recommended for these individuals.

Eligibility criteria:
inclusion criteria: * male subjects aged 20-65 years with ed complaints for at least 6 months will be included in the study. in addition, sexually active individuals will be included in the study exclusion criteria: * patients with diabetes and renal diseases, uncontrolled hypertension, priapism, pacemaker users, history of psychiatric or psychological illness, skin lesions/ulcer in the penis or lumbosacral region, and patients who are unable to cooperate will be excluded.

Keywords: erectile dysfunction connective tissue massage
mk0431 (sitagliptin) and metformin co-administration factorial study in patients with type 2 diabetes mellitus (0431-036)

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to determine the safety and effectiveness of an investigational drug in patients with type 2 diabetes mellitus (t2dm) (a specific type of diabetes).


Eligibility criteria:
inclusion criteria: 54-week base study: * patients between the ages of 18 and 78 with type 2 diabetes mellitus (a specific type of diabetes) 50-week extension study: * patients who complete the 54-week base study are eligible to enter the 50-week extension study exclusion criteria: * patients who do not have type 2 diabetes mellitus (a specific type of diabetes)