Kornimate/medical-research-clean huggingface dataset:
the effects of discharge education program on recovery and quality of life after cardiac surgery

Conditions: Cardiac Surgery, Heart Surgery, Discharge Education, Nursing, Telenursing, m-Health, Quality of Life, Recovery

Summary: this study aims to build a new discharge education, booklet and mobile application based, and assess it's efffects on recovery and quality of life in cardiac surgery patients. this is a randomised control trial. 12 weeks follow up will be done by phone calls.

patients following cardiac surgery will be part of the study. patients will be randomized in control and case groups. control group receive standart discharge eduation from the nurses of the hospital, they will be interviewed by the researcher to gather general information and also information about recovery and quality of life. case group will be given a discharge education by the researcher before discharge. after education patients will be given a booklet and a mobile application with the neccasary discharge information. both groups will be followed for 12 weeks by monthly phone calls. in the last call recovery and quality of life will be reassesed.

Eligibility criteria:
inclusion criteria: * to agree to participate in the research, * open heart surgery patients * being 18 years or older, * being able to read, write, understand and communicate in turkish, * no vision, hearing and perception problems, * being conscious, oriented, cooperative and open to communication. exclusion criteria: • having surgery other than open heart surgery

Keywords: cardiac surgery, heart surgery, discharge education, nursing, telenursing, m-health, quality of life, recovery
effect of melatonin on reduction of pelvic pain

Conditions: Dysmenorrhea; Endometriosis

Summary: in two double blinded randomized controlled trials (rct) we will study the effect of pain reduction of melatonin vs placebo in women with severe dysmenorrhea and women with endometriosis.the aim is to find an effective method for pelvic pain caused by dysmenorrhea and endometriosis.the primary outcome is reduction of pain in patients with dysmenorrhea and endometriosis respectively when treated with melatonin vs placebo. secondary outcomes include the effect on daily life, quality of life and cognition. sleep will also be assessed to evaluate its potential relation to quality of life and cognition.

two substudies will be performed. forty women with severe dysmenorrhea will be randomized to treatment with 10 mg melatonin daily or placebo during the menstruation for 2 menstrual cycles. another 40 women with endometriosis will be randomized to treatment with 20 mg or placebo daily during 8 weeks. participants will report drug intake, bleeding details (duration and amount) and pain as well as possible side effects. they will also perform a test for sleep quality and cognition before and after completion of the study. see protocol for more details

Eligibility criteria:
dysmenorrhea group inclusion criteria: * regular menstrual cycles, * severe dysmenorrhea (nrs\>6) * speaks and understands swedish * if other medication, those should be un-altered for the last 3 months exclusion criteria: * smoker * prior or ongoing liver or kidney disease * endometriosis * pregnancy endometriosis group: criteria for inclusion: * endometriosis (endometriomas or diagnosis by laparoscopy) * moderate to severe pain (nrs \>/= 4) * good general health * understands and speaks swedish * if any other treatment, unchanged regimen for the last 3 months * signed informed consent criteria for exclusion: * prior or ongoing disease in kidney or liver * use of opioid analgesics * smoker * pregnant
acupuncture for polycystic ovarian syndrome

Conditions: Polycystic Ovary Syndrome

Summary: this is a randomized control trial of acupuncture for women with polycystic ovary syndrome. the study is triple-blinded.


Eligibility criteria:
inclusion criteria: * ages 18-43 * confirmation of pcos through the study * signed informed consent * able to receive study treatment at virginia study sites * agree not to use hormonal medications for the 5 months of the study exclusion criteria: * pregnant * use of hormonal drugs 30/60 days before the study entry * acupuncture for ovulatory disorders 30 days prior to study entry

Keywords: pcos ovulation hormones women
crushed vs. uncrushed prasugrel in stemi patients undergoing pci

Conditions: Cardiovascular Diseases

Summary: the studys evaluates the effect of prehospital administration of crushed tablets of prasugrel loading dose (in addition to asa and standard care) versus uncrushed tablets of prasugrel loading dose on efficacy and safety as well as pharmacodynamics as measured by platelet reactivity using verifynow.

the study is a two-centre, randomized, 1:1 trial comparing prehospital prasugrel initiation therapy between crushed vs. uncrushed prasugrel tablets on efficacy and safety as well as pharmacodynamics in stemi patients. patients with stemi planned for primary pci will be screened and, if inclusion criteria are met, included at first medical contact (paramedics). after enrolment, patients will be randomly assigned (1:1) to receive 60mg prasugrel loading dose by ingesting integral or crushed tablets. the follow-up duration is 12 months, i.e. clinical outcomes will be analysed in-hospital, at 30 days, and 12 months

Eligibility criteria:
inclusion criteria: consecutive patients with stemi planned for primary pci: * deferred written informed consent within 4 hours after prasugrel loading dose * adult men and women aged at least 18 years * symptoms of acute mi of more than 30 min but less than 6 hours * new persistent st-segment elevation ≥ 1 mm in two or more contiguous ecg leads exclusion criteria: * contraindication to prasugrel (e.g., hypersensitivity, active bleeding, history of previous intracranial bleed, history of any cva including tia, moderate to severe hepatic impairment, gi bleed within the past 6 months, major surgery within past 4 weeks) * patient who has received loading dose of clopidogrel or ticagrelor for the index event or are on chronic treatment of ticagrelor, or prasugrel. however, patients on maintenance dose clopidogrel for at least 7 days are included in the study (see appendix a). * oral anticoagulation therapy that cannot be stopped (i.e. patients requiring chronic therapy) * planned fibrinolytic treatment * patient requiring dialysis * known, clinically important thrombocytopenia * known clinically important anaemia * known pregnancy or lactation * need for a concomitant systemic therapy with strong inhibitors or strong inducers of cyp3a * condition which may either put the patient at risk or influence the result of the study (e.g., cardiogenic shock with severe hemodynamic instability, active cancer, risk for non-compliance, risk for being lost to follow up) * patient unable to swallow oral medication (i.e. intubated patients) * patient who have not received prasugrel loading dose in the ambulance * patient who vomited after randomization / receiving the loading dose prasugrel

Keywords: stemi
study to determine skin irritation and/or sensitization potential of an antifungal cream containing trolamine (repeated insult patch test)

Conditions: Hypersensitivity

Summary: in this study researcher want to learn more about possible skin reactions such after repeated application of an antifungal cream containing trolamine. they are especially interested in skin irritations or allergic skin reactions. the study plans to enroll about 225 female or male participants with the age 18 - 79 years. the antifungal test cream will be applied on the back between the shoulder blades of the participants and covered by a special dressing patch. this will be repeated 3 times a week for the first 3 weeks of this study applying the cream on the same area of the back. at each visit the skin will be investigated for redness, dryness and other reactions. after a rest period of two weeks the test cream will be applied on the same skin area as before and on a second new skin area nearby. after 2 and 4 days the two skin areas will again be investigated for redness, dryness and other reactions.


Eligibility criteria:
inclusion criteria: * subjects must have been aged 18 to 79 years, inclusive; * female subjects must have produced a negative urine pregnancy test prior to the initiation and also at the completion of the trial; * subjects must have been capable of understanding and following directions. exclusion criteria: * subjects who were in ill health or taking medication, other than birth control, which could influence the purpose, integrity or outcome of the trial; * subjects who had any visible skin disease that might be confused with a skin reaction to the test material; * subjects who were participating in another clinical trial at this facility or any other facility; * subjects who used topical or systemic steroids or antihistamines for at least 7 days prior to trial initiation and during the duration of the trial; * subjects who had a history of adverse reactions to adhesive tape, cosmetics, otc drugs or other personal care products; * subjects judged by the pi to be inappropriate for the trial; * female subjects who were pregnant as evidenced by a urine pregnancy test, planning to become pregnant, or nursing during the course of the trial.
association between post-covid infection status and perioperative morbidity: a ambispective cohort study

Conditions: COVID-19; Complication of Anesthesia; Complication of Surgical Procedure; Complication,Postoperative; Sars-CoV-2 Infection

Summary: with the knowledge of currently transmitted omicron variant being less virulent, over 90 percent of the chinese population is fully vaccinated, and the chinese health workers have sufficient experience treating the illness. china 's epidemic prevention and control has entered a new stage to restore the normal functioning of society and basic medical services, on dec, 7, china released a circular on further optimizing its covid-19 response, announcing 10 new prevention and control measures.this has marked the watershed for sharply increased number of elective surgical patients diagnosed with covid-19 during preoperativley, fully recovered or during recovery. beijing faced a wave of omicron infection starting that would result in of a wide range of population infections. at which time there is limited evidence regarding the optimal timing of surgery following sars-cov-2 infection especially for omiron among chinsese patients .this study intends to explore the relationship between the incidence of postoperative complications after elective surgery and covid-19 infection in peking union medical college hospital, and provide data support for the policy formulation of elective surgical timing for patients after covid-19 infection.


Eligibility criteria:
inclusion criteria: 1. all patients having pre-operative sars-cov-2 infection diagnosis dec 1st 2022 to feb 28th 2023. \[the covid-19 diagnosis is based on either (a) a positive rt-pcr nasopharyngeal swab, (b) positive antigen rest before surgery, or (c) clinical diagnosis made before surgery\]. exclusion criteria: 1. patients diagnosed with sars-cov-2 infection on the day of surgery or during postoperative days. 2. day surgery or outpatient surgery. 3. patients unwilling to participate or provide covid-19-related information.
effects of exercise on dystonia pathophysiology

Conditions: Dystonia

Summary: the purpose of this research study is to investigate how the brain and motor behavior changes in individuals with dystonia in response to exercise training.

dystonia is a debilitating movement disorder. it involves involuntary muscle contractions with abnormal and repetitive movements, postures, or both. the current treatments for dystonia comprise of oral medications, botulinum toxin injections, and deep brain stimulation surgery. these treatments, despite optimal management, fail to improve symptoms in more than a third of patients and the improvements are often unpredictable. we will investigate the brain adaptation effects for progressive resistance exercise-focused cervical and shoulder training (perfect) in patients with focal cervical dystonia with functional mri (fmri) and transcranial magnetic stimulation (tms) techniques for understanding the pathophysiology of dystonia and treatment related changes. the investigators propose to enroll patients with predominantly focal cervical dystonia and compare perfect plus standard-of-care (soc) therapy (n = 27) with a control group of soc therapy (n = 27). participants in the perfect + soc group will perform physical therapist-guided exercises twice a week for 6 months and participants in the soc group will continue receiving standard pharmacological therapies at stable doses and they will not exercise.

Eligibility criteria:
inclusion criteria: * patients have predominantly focal cervical dystonia and whose diagnosis will be confirmed by a movement disorders specialist following criteria recommended by movement disorders society. * moderate disease severity. * are 30 to 85 years old * are able to tolerate exercise sessions. * reporting suboptimal clinical benefits despite receiving maximally tolerated doses of bont injections for the neck muscles and/or oral pharmacological therapy. exclusion criteria: * participating in an alternate structured exercise program, receiving regular physical or occupational therapy * have significant pain, spondylosis or active arthritis * fail the physical activity readiness questionnaire * have significant cognitive impairment * have implanted electrical device (eg, cardiac pacemaker or a dbs or a neurostimulator or metallic clip in their body, as necessitated by the risks of mri or tms * active seizure disorder; not be eligible for tms and claustrophobic for mri portion. as necessitated by the risks of mri or tms, patients who have any type of implanted electrical device (such as a cardiac pacemaker or a neurostimulator), or a certain type of metallic clip in their body (i.e., an aneurysm clip in the brain), active seizure disorder are not eligible for participation in the mri or tms portion of the study. * pregnancy tests will be carried out for each female subject of child bearing potential prior to the participation in the study and prior to each follow up visit (as indicated).
links between cognitive functions and clinical, biological and neuroradiological outcomes in adults with sickle cell disease.

Conditions: Sickle Cell Disease; Drepanocytosis

Summary: sickle cell disease (scd) is an inherited blood disorder. symptoms include acute and chronic complications. due to progress in scd care, patients with scd are living longer than before and we focus more attention in chronic complications. children with scd experience worse cognitive functions than healthy children, and fewer is known about cognitive functions in adults. studies suggest lower cognitive performance in scd, mostly in executive functions and processing speed, but the biological and anatomical substrates of cognitive decline are not yet well established in scd. often times, cognitive impairments and cerebral disorders are not diagnosed and treated in adults with scd. the main objective of this study is to propose a deep neuropsychological assessment in adults with scd and cognitive complaints and to highlight links between cognitive functions and clinical, biological and neuroradiological markers. the hypothesis of this study is that cognitive functions are associated with severity of the scd, with bood abnormalities, with mri markers and transcranial doppler (tcd) markers of cerebrovascular disease. the secondary objective of this study is to validate a brief cognitive assessment tool (bearni tool) in adults with scd. this study is an observational cross-sectional study that will enroll adults with scd and cognitive complaint.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * sickle cell anemia (homozygous ss or heterozygous sc, sβ0, s/c, sβ+) * in steady state (without vaso-occlusive crisis or acute chest syndrome at the time of measurements) * presence of spontaneous cognitive complaint or requested by the physician. * good command of the french language (native language or not) * no objection to participate in the study * affiliated patient or beneficiary of social security scheme exclusion criteria: * patient not compliant in the management of his disease * patient participating in another interventional research protocol that may interfere with this protocol (according to investigator's judgment) * language barrier * pregnancy or breast feeding * mri contraindication * patient under guardianship , curatorship or justice * inability to express non-opposition

Keywords: sickle cell disease drepanocytosis
allogeneic transplantation using total lymphoid irradiation (tli) and anti-thymocyte globulin (atg) for older patients with hematologic malignancies

Conditions: Blood Cancer; Leukemia

Summary: to measure how frequently and to what degree a complication of transplant cell acute graft versus host disease (gvhd) occurs.

this study evaluated whether tli-atg conditioning followed by allogeneic hematpoietic cell transplant (hct), which has provided excellent overall survival for patients with relapsed lymphoma after failed autologous hct, provides a similar benefit in the setting of elderly patients with hematologic malignancies.

Eligibility criteria:
inclusion criteria: * any patient with one of the following hematolymphoid malignancies or syndromes in whom allogeneic hematopoietic stem cell transplant (hst) is warranted. specific disease categories include: * indolent advanced stage non-hodgkin lymphomas * mantle cell lymphoma * chronic lymphocytic leukemia * hodgkin disease (hodgkin's lymphoma) * acute leukemias in complete remission * aplastic anemia * paroxysmal nocturnal hemoglobinuria * myelodysplastic or myeloproliferative syndromes. * other selected malignancies/disorders may also be considered but must be approved by the transplant team and the principal investigator. * age \> 50 years, or if \< 50 years of age, considered to be at high risk for regimen-related toxicity associated with conventional myeloablative transplants due to pre-existing medical conditions or prior therapy. * a fully human leukocyte antigen (hla)-identical sibling or matched unrelated donor is available. potential participants with one antigen mismatched donors can be considered but only after discussion with the transplant team and the principal investigator. * participant must be competent to give consent. exclusion criteria: * progressive hematolymphoid malignancies despite conventional therapies, or acute leukemias not in complete remission. * uncontrolled central nervous system (cns) involvement with disease * fertile men or women unwilling to use contraceptive techniques during and for 12 months following treatment * pregnant * cardiac ejection fraction \< 30% * uncontrolled cardiac failure * pulmonary diffusing capacity (dlco) \< 40% predicted * elevation of bilirubin to \> 3 mg/dl * transaminases \> 4 x the upper limit of normal * creatinine clearance \< 50 cc/min (24-hour urine collection) * karnofsky performance score \< 60% * poorly controlled hypertension on multiple antihypertensives * documented fungal disease that is progressive despite treatment * hiv-positive. other viral infections, ie, hepatitis b- and c- positive, evaluated on a case-by-case basis * psychiatric disorders or psychosocial problems which in the opinion of the primary physician or principal investigator would place the patient at unacceptable risk from this regimen.
prevalence, severity and determinants of cancer-related fatigue (crf) in asian breast cancer patients

Conditions: Fatigue; Chemotherapy; Breast Cancer; Supportive Care

Summary: there is a paucity of studies that focus on the symptom burden of cancer patients in singapore, particularly the clinical effects of cancer-related fatigue (crf). knowing that early-stage breast cancer is curable, it is of paramount importance to evaluate the clinical and biological determinants of lingering symptoms in breast cancer survivors so that appropriate psychosocial interventions can be formulated.

the investigators hypothesize that variations in clinical and biological determinants contribute to different severities of crf among asian breast cancer patients. through this study, the investigators aim to evaluate the prevalence and severity of crf among asian breast cancer patients, and to identify the biological and clinical determinants of crf among these patients. this will be a multicenter, prospective, longitudinal, observational study conducted at the national cancer centre singapore and kk women's and children's hospital. informed consent will be obtained from participants before the investigators proceed with data collection. the study participants will be assessed at relevant time points. biological determinants and symptoms associated with crf will be assessed. the associations between changes in crf, plasma cytokines levels, serum cortisol levels, and other clinical determinants will be elucidated.

Eligibility criteria:
inclusion criteria: * at least 21 years of age * stage i-iii breast cancer * chinese, malay or indian ethnics * surgical treatment has been performed * scheduled to receive four cycles of chemotherapy (doxorubicin/cyclophosphamide \[ac\], docetaxel/cyclophosphamide \[tc\], 5-fluorouracil/epirubicin/cyclophosphamide \[fec\]) (total duration of 3 months) and/or radiotherapy and/or hormonal therapy * no prior history of chemotherapy and/or radiotherapy * able to read and understand either english or mandarin exclusion criteria: * physically or mentally unable to provide verbal/written consent * symptomatically ill (such as infection or an allergic reaction to chemotherapy) * presence of another condition for which fatigue is a prominent symptom (e.g. aids, fibromyalgia, or rheumatoid arthritis) * newly started on any medications that can cause general fatigue and body weakness (e.g. a beta-blocker or antidepressant, antihistamine, or antipsychotic medication) * presence of neurologic or immune-related medical condition or behavior known to influence the immune system (e.g. smoking or heavy drinking)

Keywords: fatigue chemotherapy breast cancer supportive care singapore