Kornimate/medical-research-clean huggingface dataset:
body image therapy in anorexia nervosa

Conditions: Anorexia Nervosa

Summary: the purpose of the study is to test a new procedure of body image therapy in anorexia nervosa, using the anamorphic micro software.

anorexia nervosa is a severe psychiatric disorder, with high level of mortality and hospitalization is often necessary for the treatment of severe and/or chronic cases. anorexic patients often experience a serious disturbance in body and their own shape perception. body image work should be enhanced in the treatment of anorexia nervosa. the aim of the study is to test a new body image therapy using the anamorphic micro software. ten sessions of assessment of the patient's own shape and of correction of distorted perceptions of body size with anamorphic micro software will be compared to ten sessions of body image therapy as usual. french 100 anorexia women hospitalized in a specialized eating disorder unit will participate to the study, randomized in 2 arms : * body image therapy with anamorphic micro software * body image therapy as usual

Eligibility criteria:
inclusion criteria: * woman * more than 18 years old * anorexia nervosa * hospitalized in the cmme (chsa) tca unit * body mass index ≥ 16 * informed consent exclusion criteria: * pregnancy * severe motor, sensitive or sensorial impairment * no affiliation of national health service * dependent of a trusteeship or guardianship

Keywords: anorexia nervosa cmme-tca unit centre hospitalier sainte anne
the effects of disease management programs for prevention of recurrent ischemic stroke

Conditions: Ischemic Stroke

Summary: it has been reported that stroke is the first cause of becoming bedridden, and its cumulative recurrence rate in 5 years is approximately 35%. there is a high probability that patients reduce or discontinue medications by self-determination, leading to a high risk of stroke recurrence in these patients. comprehensive and long-term patient educations ameliorating their self-management are important making patients possible to be managed according to the guidelines for their risk factors. using disease management programs created for each of risk factors according to clinical practice guidelines, the influence of those programs were evaluated for the prevention of stroke recurrence in this disease management program stroke trial.


Eligibility criteria:
inclusion criteria: * ischemic stroke onset \[including transient ischemic attack (tia)\]. * receiving regular consultation with their primary care physician. * modified rankin scale (mrs) score from 0 to 3 at discharge. exclusion criteria: * modified rankin scale (mrs) score 4 and over at discharge . * patient having severe complications and the physical symptom that the contents of the program cannot carry out. * they had medical care in medical/nursing care institutions. * patients with pregnancy or under terminal care. * dementia (scores of ≤20/30 on the revised hasegawa's dementia scale) however, when a care-giving family member living with the patient could provide self-management, patients were included even if they had dementia.

Keywords: stroke, disease management programs, self-management
nursing intervention for the reduction of anxiety during the process of primary total hip arthroplasty within the optimized recovery program.

Conditions: Osteoarthrosis; ERAS; Anxiety; Nurse

Summary: osteoarthrosis (oa) is a chronic, degenerative disease characterized by joint wear and tear. it is a major cause of pain, disability and decreased quality of life. total hip arthroplasty (tha) and total knee arthroplasty (tka) represent an effective alternative for the treatment and pain control of patients with osteoarthritis. the "fast-track" program is translated as enhanced recovery or fast-track, and consists of the active participation of patients in their own recovery and immediate post-surgical mobilization, thanks to preoperative education through an educational workshop, the type of analgesia used and the empowerment of the patient in his or her own recovery. the problem of anxiety in the surgical patient and the role of nurses in it has been widely studied for some decades, as shown in the scientific literature. our experience as professionals of a hospital unit of orthopedic surgery and traumatology shows us the reality of this situation and the investigators find that when discharging patients who have undergone surgery and are discharged after 24 hours, the patient almost globally manifests a series of expressions, behaviors or behaviors that are related to anxious behavior, a completely natural human response of a patient who does not know what he is going to face. this leads us to detect a need to reinforce the information provided at discharge and the accompaniment during the first weeks after discharge. anxiety is a complex reaction to potentially dangerous situations or stimuli. it is an alarm signal that triggers a series of responses to cope with the situation. anxiety is an emotional response that encompasses unpleasant cognitive aspects and physiological alterations that manifest themselves with high nervousness and even motor alterations. surgery is perceived by the patient as an important stress factor that can translate into nervousness and anxiety. anxiety is almost always present during surgery, to a greater or lesser degree, both preoperatively and postoperatively. several studies have shown that good preoperative information reduces preoperative and postoperative anxiety. patients need information about their process since dispelling their doubts will minimize anxiety. currently there is very little information on anxiety during the whole surgical process. therefore, in the present project the investigators propose to carry out a research study to analyze whether nursing intervention has beneficial results in the surgical patient.


Eligibility criteria:
inclusion criteria: * patients scheduled with signed consent for primary hip arthroplasty surgery, age over 18 years, patients who agree to participate in the study. exclusion criteria: * patients who are discharged to a social-health center, patients with cognitive or mental disorders, patients who cannot read or write.

Keywords: hip arthroplasty eras nursing care
nitrate supplementation and muscle blood flow

Conditions: Vasodilation; Blood Pressure; Active Hyperemia; Aging

Summary: the main purpose of this study is to evaluate the effects of an acute dose of dietary nitrate in the form of beetroot juice on skeletal muscle blood flow in response to dynamic knee extension exercise in healthy older adults. all subjects will receive active (rich in dietary nitrate) or placebo (devoid of nitrate) supplementation.

dietary nitrate (beetroot juice) is reduced to nitrite and nitric oxide within the digestive system of humans. nitric oxide exerts potent vasodilator effects, which have been shown to reduce blood pressure and enhance exercise economy in humans. this pressure reducing effect may have implications within the regulation of blood flow during dynamic exercise in older adults.

Eligibility criteria:
inclusion criteria: * healthy older adults 60-80 years of age exclusion criteria: * hypertension, * smoking, * heart disease, * diabetes, * body mass index (bmi) ≥ 30 kg/m2, * autonomic disorders and other conditions that may alter blood pressure or vascular function * medications that might normally alter blood pressure or vascular function. * older women taking hormone replacement therapy medications.

Keywords: exercise hyperemia vasodilation nitric oxide dietary nitrate
dedicated breast ct for diagnosis of breast cancer

Conditions: Breast Cancer

Summary: dedicated breast computed tomography (bct) is being developed as a new x-ray based tomographic breast imaging method for early breast cancer detection and/or diagnosis. bct results in isotropic high spatial resolution three-dimensional (3d) images coupled with high contrast resolution. it is hypothesized that bct imaging used as a replacement of the additional mammographic views during diagnostic work-up will improve the accuracy of clinical standard diagnostic work-up.

rationale: dedicated breast computed tomography (bct) is being developed as a new x-ray based tomographic breast imaging method for early breast cancer detection and/or diagnosis. bct results in isotropic high spatial resolution three-dimensional (3d) images coupled with high contrast resolution. it is hypothesized that bct imaging used as a replacement of the additional mammographic views during diagnostic work-up will improve the accuracy of clinical standard diagnostic work-up. objective: the primary objective of this research project is to determine the improvement in the area under the receiver operating characteristics (roc) curve of bct for diagnosis of breast cancer compared to that of the standard diagnostic work-up. as secondary objectives, this analysis will be performed by lesion type (microcalcifications vs. soft tissue lesions). study design: single arm study with each subject being its own control

Eligibility criteria:
inclusion criteria: * women age 50 or older initial schema: - women who are scheduled to undergo a diagnostic work-up following an abnormal screening mammogram with the suspicious finding not located in the axillary tail of the breast this initial inclusion criterion will be used until 85 subjects that result in a breast imaging reporting and data system (bi-rads) 1 or 2 after clinical diagnostic work-up are recruited and imaged. subsequent schema: - women who underwent diagnostic work-up following an abnormal screening mammogram and were assigned a bi-rads 4 or 5 due to soft tissue lesions (total 120 patients when combined with those from the initial schema), or due to microcalcifications (total 120 patients when combined with those from the initial schema) with the suspicious finding not located in the axillary tail of the breast each patient can only enroll once in the study. exclusion criteria: * women who do not meet the inclusion criteria as described above * women with suspected or confirmed pregnancy * women who have had bilateral mastectomy * women whose suspicious lesion is located in the axillary tail * women with prior breast cancer or breast biopsy in the recalled breast in the last 12 months * women who are breastfeeding * women who are very frail and unable to cooperate * women who cannot give informed consent * male subjects

Keywords: breast cancer computed tomography
evaluating the efficacy of a mobile application in postoperative rehabilitation

Conditions: Spine Degeneration; Hip Arthritis; Knee Osteoarthritis; Hip Fractures

Summary: this study aims to evaluate the effectiveness of a mobile application in improving postoperative rehabilitation outcomes among patients undergoing orthopedic surgery.

the study aims to assess the effectiveness of a mobile app-based tool in improving conditioning, mobility, and physical therapy performance among patients recovering from orthopedic surgery, particularly hip fracture fixation, spinal fusion, and total knee/hip arthroplasty. the app sets reminders for in-bed conditioning exercises, with difficulty levels adjusted based on patient feedback. the prospective, single-arm pilot study will enroll patients over 65 years old with adequate cognitive status and a mobile phone. patient performance on the app, satisfaction metrics, and physical therapy outcomes will be evaluated, along with feedback from physical therapists. the study is conducted through the yale new haven health system, with plans to enroll 15 patients initially and subsequently expand to a randomized controlled trial with 50 participants in each arm. the goal is to improve outcomes in this population, characterized by poor mobility, morbidity, and mortality rates, by supplementing inpatient rehabilitation with targeted, app-prompted exercises.

Eligibility criteria:
inclusion criteria: * provision of signed and dated informed consent form * stated willingness to comply with all study procedures and availability for the duration of the study * english reading/speaking * are status post low-energy hip fracture, total knee/hip arthroplasty, or single to multilevel spinal fusion without paralysis * must be able bodied enough to participate in a mobile app tool for physical therapy * agreement to adhere to lifestyle considerations (see section 5.3) throughout study duration\] exclusion criteria: * severe cognitive impairment: not alert and oriented to person, place, time, and reason for being the hospital; and unable to follow 2 step commands * severe physical impairment: * neurologic paralysis * polytraumas with restrictions incompatible with anti-gravity exercises * knee immobilization, bed rest * unstable medical conditions: * on ventilatory support * utilizing high degrees of oxygen support (continuous bipap, high flow nasal cannula, nonrebreather mask, aerosol mask \>3l/min) * hemodynamic instability requiring pressor medication support (can include those on pressors for elevated mean arterial pressure goals (maps)) * neurologically instable with strokes, hemorrhages, increased intracranial pressures * open wounds or surgical incisions * tenuous closed wounds requiring immobilization or bending restrictions * open wounds that are either packed/dressed or dressed with a wound vacuum * surgical wounds that are draining fluid or purulence * vulnerable populations * incarcerated individuals * patients without access to a mobile phone with ios capability
impact of web application support versus standard management on compliance with adjuvant hormone therapy at 18 months in patients treated for breast cancer

Conditions: Web-application; Breast Cancer; Hormono Therapy

Summary: the investigators hypothesize that the implementation of a web-application in patients initiating adjuvant hormone therapy for breast cancer brings a benefit on treatment adherence and quality of life.


Eligibility criteria:
inclusion criteria: * patient \> 18 years old * breast cancer patient candidate for adjuvant hormone therapy * mastery of the french language * patient with a cell phone and an internet connection * patient able to use a computer, smartphone, or tablet. * patient affiliated to a social security system * signing of informed consent prior to any specific study-related procedure exclusion criteria: * patient who has previously received hormone therapy for cancer. * patient not trained in the use of the application * any associated medical or psychiatric condition that might compromise the patient's ability to participate in the study * patients with locoregional or metastatic recurrence * other history of cancer. * patient deprived of liberty, under guardianship or curatorship * simultaneous participation in a therapeutic clinical trial or other clinical study involving a connected tool * patient unable to undergo trial follow-up for geographical, social or psychopathological reasons
relevance of reactive hypoglycemia during an ogtt in everyday life using continuous glucose measurement

Conditions: Hypoglycemia, Reactive

Summary: this research project aims to investigate the everyday relevance of reactive hypoglycemia (hypoglycemia after a glucose load) in the oral glucose tolerance test (ogtt). therefore, blood glucose profiles in everyday life will be examined using continuous glucose measurement (free style libre pro iq system) over a period of 14 days in affected persons.

the aim of this analysis is to examine people who underwent an ogtt due to various endocrinological and metabolic issues and developed reactive hypoglycemia, defined as a drop in blood glucose \<70mg/dl during the course of the test. during ogtt routine laboratory testing will be performed as part of routine clinical practice. in order to investigate the occurrence and perception of hypoglycaemia in the everyday lives of those affected, their blood glucose profiles will be recorded and evaluated over a period of 14 days. in addition, the perception of (suspected) hypoglycemia and counteraction will be documented. anthropometric data will be recorded and a bioelectrical impedance analysis performed to check a correlation with the body composition. subjects will be recruited via the endocrinology outpatient clinic as part of medical care. to date, very little cgm data are available on the frequency and extent of reactive hypoglycemia in the everyday lives of people without diabetes mellitus. therefore, 20 subjects with hypoglycemia in the ogtt will be included in this exploratory pilot study for hypothesis generation in order to investigate the occurrence and perception of hypoglycemia in everyday life.

Eligibility criteria:
inclusion criteria: * hypoglycemia during a 75 g oral glucose tolerance test defined as glucose level below 70 mg/dl at timepoint 180 min. * written consent exclusion criteria: * diabetes mellitus * use of medication interfering with glucose metabolism (steroid, antidiabetic medications) * surgery of upper gi-tract * known plaster allergies * any other clinical condition that would endanger participants safety or question scientific success according to the physicians opinion

Keywords: reactive hypoglycemia oral glucose tolerance test continuous glucose monitoring
acupuncture for urinary incontinence

Conditions: Urinary Incontinence

Summary: this research study will evaluate the effectiveness of acupuncture in decreasing urinary incontinence (involuntary urine loss) in women. the study will involve 12 acupuncture sessions over 6 weeks. we will compare the effectiveness of acupuncture and sham (placebo) acupuncture (a procedure in which the needle feels like it penetrates the skin, but is not actually inserted into the body) on the frequency and volume of involuntary (accidental) urine loss after completing the intervention, and again one month later. individuals participating in this study will be randomly assigned to receive either the actual or sham acupuncture. randomization means being assigned by chance, similar to flipping a coin. study participants will not know which group (actual or sham acupuncture) they were assigned to until one month after completing the 6-weeks of treatment. the sham acupuncture needles look similar to the real acupuncture needles and feel like they penetrate the skin, but do not actually do so. if individuals are assigned to the sham acupuncture group, they will be eligible to receive the actual acupuncture one month after completing the sham acupuncture if they wanted to. all individuals will be followed for 6 months after completing the acupuncture treatments.

see brief summary

Eligibility criteria:
inclusion criteria: * urge or stress urinary incontinence at least twice a week on average for at least 3 months exclusion criteria: * history of previous acupuncture * history of a neurologic problem such as parkinson's disease or multiple sclerosis that could affect bladder function * current treatment with overactive bladder medications or medications that relax the bladder * urinary catheter * pregnancy * inability to empty the bladder effectively * inability to toilet independently * current treatment with steroid * interstitial cystitis * chronic pelvic pain * current treatment with warfarin

Keywords: urinary incontinence
geriatric-co-management for cardiology patients in the hospital

Conditions: Geriatric Assessment; Health Services for the Aged; Cardiovascular Diseases; Activities of Daily Living; Delirium; Frail Elderly; Length of Stay

Summary: the primary objective of the evaluation study is to determine if geriatric co-management is superior to standard of care in preventing functional decline in older patients admitted for acute heart disease or transcatheter aortic valve implementation (tavi) to the cardiology units of the university hospitals leuven.

this study aims to implement and evaluate a geriatric co-management intervention in older patients admitted for acute heart disease or transcatheter aortic valve implementation (tavi) to the cardiology units of the university hospitals leuven. the study uses a mixed-methods methodology aiming to 1) assess the feasibility and evaluate the effectiveness of geriatric co-management, 2) describe the experiences of intervention participants, and 3) perform a process evaluation. we will first consecutively recruit patients on the cardiology units to measure the standard of care in the control group. the geriatric co-management intervention will then be implemented and piloted on the participating units. once fully implemented, we will consecutively recruit patients for the intervention group who will receive the geriatric co-management intervention.

Eligibility criteria:
inclusion criteria: patients will be included if they: * are admitted for non-surgical treatment of an acute heart problem (patients may be admitted through the emergency department or the cardiology outpatient services for any heart related acute disease) or if they are admitted for transcatheter aortic valve implantation (tavi); * are aged 75 years or older; * have an expected length of stay of three days or longer; * non-palliative on hospital admission * are dutch speaking and testable; * give informed consent or proxy-informed consent; exclusion criteria: patients will be excluded if they: * are admitted from another hospital unit or other hospital; * have been admitted to the intensive care unit for three days or longer;

Keywords: geriatric nursing geriatric co-management geriatric team
safety and efficacy of str001-it and str001-er in patients with sshl

Conditions: Acute Hearing Loss

Summary: a multicenter, double-blind, placebo-controlled study in patients with sudden sensorineural hearing loss (sshl). patients will be treated with str001 thermogel (str001-it) / str001 tablets (str001-er) and corresponding placebo on top of standard of care.


Eligibility criteria:
inclusion criteria: 1. male or female patients aged ≥ 18 2. patients with a sshl within 96 hours of its perception 3. sudden sensorineural hearing loss including 1. idiopathic unilateral sudden sensorineural hearing loss or 2. acute uni- or bilateral acoustic trauma-induced sudden sensorineural hearing loss exclusion criteria: 1. patients with a history of meniere's disease 2. patients with a hearing threshold above 100 db across at least 6 frequencies 3. patients with endolymphatic, hydrops or history of fluctuating hearing loss 4. patients with suspected perilymph fistula, membrane rupture, retrocochlear lesions or a barotrauma 5. patients with an air-bone gap of ≥ 20 db in 3 contiguous frequencies at baseline 6. previous sshl incident at the same ear 7. patients with acute or chronic otitis media or otitis externa. 8. patients with congenital hearing loss 9. patients with known hypersensitivity to pioglitazone, other thiazolidindiones or any formulation component 10. use of thiazolidinedione (e.g. pioglitazone, rosiglitazone) in the last 6 months prior to baseline 11. any use of cyp450 2c8 inducers (e.g. rifampicine) 12. fibrates (e.g. gemfibrozil, fenofibrate) in the last 6 months prior to baseline 13. patients where oral administration of pioglitazone is contraindicated (i.e. cardiac failure or history of cardiac failure (nyha stages i to iv), hepatic impairment, diabetic ketoacidosis, current bladder cancer or a history of bladder cancer, uninvestigated macroscopic haematuria 14. women who are breastfeeding, pregnant or plan to get pregnant during the trial duration 15. women of childbearing potential unwilling or unable to practice effective method of contraception 16. participation in other clinical trials in the last month prior to baseline