Kornimate/medical-research-clean huggingface dataset:
efficacy of the "living with type 1 diabetes to grown-up" interactive podcast program

Conditions: Type 1 Diabetes Mellitus

Summary: the present study aims to evaluate the intervention effectiveness of the online interactive podcast program"living with type 1 diabetes to grown-up"in patients with type 1 diabetes transitioning from adolescence to early adulthood.

individuals aged 16-25 with type 1 diabetes (t1d) face significant transitional challenges in their lives, with an increased risk of worsening disease management. addressing these challenges, an interactive podcast program, \&#34;living with type 1 diabetes to grown-up\&#34;; is being developed with a one-year grant from the national science and technology council. this continued project will span three years, employing a mixed-method research design for evaluation. participants will be recruited from pediatric endocrinology and genetics clinics and wards across two medical centers in northern taiwan. in line with recommendations from prior reviewers, the study will incorporate a two-phased approach: the first phase is a quantitative study, structured around transitional theory and self-regulation theory using pride steps. it adopts a double-blinded, randomized controlled experimental method with data collector and sham treatment participants blinded. subjects will be randomly assigned to either the experimental group (n=44) or the active control group (n=44). comparative analyses will focus on variations in disease control, emotional disturbance, confidence in self-management, self-care behaviors, diabetes knowledge, interpersonal disturbance, and family conflict at baseline, and post-interventions of immediate, 3-month, and 6-month periods. in the subsequent qualitative phase, 15-20 cases from the experimental group will be selected for in-depth interviews to evaluate the impact of the \&#34; living with type 1 diabetes to grownup \&#34; interactive podcast program. the outcomes of this research are anticipated to contribute significantly to the clinical management and technological intervention strategies for t1d adolescents in their transitional phase to adulthood.

Eligibility criteria:
inclusion criteria: * a confirmed diagnosis of t1d by an endocrinologist before the age of 16 and a disease duration of \>6months * patients aged 16-25 years * mean hba1c level ≥7.5% one year before inclusion * ability to communicate in chinese or mandarin * patients who own smartphones with internet access * patients who agreed to voice recording during a session explaining the treatment process * patients who signed the informed consent form prior to participation; for minors, a legal representative must provide consent and sign the informed consent form. exclusion criteria: # t1d patients with other concomitant metabolic diseases, chromosomal aberrations, major illnesses, and cognitive impairment will be excluded from this study.

Keywords: type 1 diabetes transition podcast self-regulation
excessive avoidance behaviors in anorexia nervosa: the role of reward

Conditions: Eating Disorders; Anxiety; Anorexia Nervosa

Summary: this study investigates excessive avoidance behaviors in patients with a diagnosis of anorexia nervosa (an) compared to a healthy control group. the study further examines the role of reward (relief) as a putative factor in maintaining excessive avoidance behaviors in an.

anorexia nervosa (an) is a life-threatening mental disease with a disappointing treatment outcome. fear of weight gain and diet restrictions are considered the core symptoms of an. although from a diagnostic perspective an is conceptualized as an eating-related disorder connected to an extremely low body mass index (bmi) and body image distortion, an might represent a specific phenotype of anxiety disorders characterized by tenacious avoidance behaviors, especially the restrictive subtype. to date, avoidance in an is often investigated as a general personality trait (e.g. harm avoidance) but poorly examined in its behavioral form (which is life-threatening, such as food-avoidance). hence, the investigators will perform a systematic investigation of excessive avoidance behaviors within a laboratory setting. within a learning perspective, the investigators will investigate excessive avoidance in a group of 30 an patients and 30 healthy volunteers. to achieve this, a well-validated avoidance paradigm will be used. most critically, the investigators will examine whether patients with a diagnosis of anorexia nervosa show persistent avoidance behaviors compared to a control group. additionally, the investigators will examine if, in the anorexia group, higher subjective relief to successful omissions of negative events during avoidance learning predicts persistent (excessive) avoidance behaviors after fear extinction.

Eligibility criteria:
inclusion criteria: * for the an group, patients need to be physically strong and sufficiently emotionally stable * for the healthy group, the investigators will recruit participants without a previous or current history of psychiatric, cardiovascular, neurological or other relevant disorder exclusion criteria: * for the an group, the investigators will exclude patients who are insufficiently emotionally stable and/or physically weak to participate in the study as estimated by the treating physicians of the units on which the patients are admitted * insufficient verbal skills to understand the questionnaires and the computer task * participants who are pregnant or breastfeeding
saline against lactated ringers or plasmalyte in the emergency department

Conditions: Critical Illness; Acute Kidney Injury

Summary: this study will be a cluster-randomized, single-center trial comparing 0.9% saline (normal saline) vs physiologically-balanced crystalloid fluids (lactated ringers or plasmalyte a) for intravenous fluid administration in the emergency department.

the administration of intravenous fluids is ubiquitous in the care of the acutely ill. commonly available isotonic crystalloid solutions contain a broad spectrum of electrolyte compositions including a range chloride concentrations. recent studies have associated solutions with supraphysiologic chloride content with hyperchloremia, metabolic acidosis and renal vasoconstriction, acute kidney injury and renal replacement therapy, and increased mortality but no large, randomized-controlled trials have been conducted. salt-ed will be a large, cluster-randomized trial enrolling adults requiring intravenous isotonic crystalloid administration and hospital admission from the vanderbilt university emergency department from january 1st 2016 until april 30 2017. the primary endpoint will be hospital-free days to day 28.

Eligibility criteria:
inclusion criteria: 1. patient in the vanderbilt adult emergency department 2. felt by treating clinician to require intravenous isotonic crystalloid 3. felt by treating clinician to require inpatient hospital admission exclusion criteria: 1. age \< 18 years

Keywords: crystalloid acute kidney injury
bm-mncs and uc-mscs infusion for type 2 diabetes mellitus patients

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to evaluate the preliminary safety and efficacy of autologous bone marrow mononuclear cells (bm-mncs) and allogeneic umbilical cord tissue-derived mesenchymal stem cells (uc-mscs) infusion in type 2 diabetes mellitus patients.

mononuclear cells are collected from autologous bone marrow and allogeneic mesenchymal stem cells are isolated and cultured from umbilical cord tissues. 30 patients with type 2 diabetes mellitus will be enrolled and received mononuclear cell and mesenchymal stem cell by intravenous infusion and followed up for 6 months. the other 30 patients with type 2 diabetes mellitus will be enrolled and treated by standard medicines, which would be used as the control group. safety is to assess the occurrence of adverse events (aes) during either stem cells infusion or by physician assessments. the primary endpoint is to assess the improvement of patient's c-peptid and homa-β, homa-ir, cytokines tnf-α, il-1β, blood glucose level, hemoglobin a1c (hba1c) level.

Eligibility criteria:
inclusion criteria: * who is diagnosed with type 2 diabetes mellitus according to the ada 3 years or more * patients are able to read, write and understand icf form and agree to participate in the study * males and females between age 18 and 70 years at the screening. * fbg \> 7 mmol/l * 8% ≤ hba1c ≤ 11% * fasting c-peptide \> 0.6 ng/ml * anti gad (-) * the patient is treated by two oral diabetes medications but uncontrolled blood glucose (hba1c ≥ 8%) exclusion criteria: * pregnant women, planning to become pregnant and lactating women during the study period * the patient has a disease or a history of vascular disease; history of abdominal or chest aortic disease; * patients are diagnosed with heart failure degree iv according to nyha or kidney failure degree iv according to kdigo; * patients with severe malignancy or dysplasia within 5 years prior to the study period or who are suffering from severe malignant or dysplasia * infection is undergoing antibiotic treatment or antibiotics have just been discontinued within 14 days * hematologic disease or coagulopathy * there are abnormalities in liver function (ast and/or alt ≥ 2 times or bilirubin ≥ 2.0 times normal value at the time of screening); * patients with immunodeficiency diseases such as hiv or hepatitis b and c; * acute or chronic pancreatitis or a history of acute pancreatitis; * patients taking immunosuppressive drugs (such as azathioprine, methotrexate) within 6 months before the study time or taking immunosuppressive drugs; * the patient is unable to complete the study; * the patient is participating in another study.
breath biomarkers for sleep loss and circadian timing

Conditions: Shift-Work Sleep Disorder; Shift Work Type Circadian Rhythm Sleep Disorder; Sleep Disorders, Circadian Rhythm; Sleep Disorders, Intrinsic; Advanced Sleep Phase Syndrome (ASPS); Advanced Sleep Phase Syndrome; Advanced Sleep Phase; Delayed Sleep Phase; Delayed Sleep Phase Syndrome; Non-24 Hour Sleep-Wake Disorder; Irregular Sleep-Wake Syndrome

Summary: insufficient sleep has both health and safety risks, but currently there are no quick, accurate and inexpensive ways to measure sleep deficiency. the current study aims to use a cutting-edge technology, small molecule analysis (e.g. metabolomics), to detect compounds in breath that reliably change with sleep-wake state and those whose levels vary by time of day.

the goal of the study is to use a small molecule analysis (e.g. metabolomics) device to measure compounds in breath that may change with sleep-wake state and compounds that vary by time of day. participants will be fitted with a plastic mask connected to the device for a breath analysis test for about 20 minutes. then, participants may be asked to lie down and take a nap or to remain sitting/lying down for 1-2 hours. after such time, participants will be asked to complete another \~20 minute breath analysis test. participants will be asked to complete questionnaires throughout the study session. investigators may ask participants to provide up to two saliva samples during the study session. participants will also be asked to complete a pre-study diary to document sleep/wake times, diet, and medications for the day before the study session. participants may be asked if they would be willing to take part in an additional study session on another day.

Eligibility criteria:
inclusion criteria: * healthy adults who are able to fall asleep in the study conditions * beginning 2 hours before the study, participants will be asked to refrain from brushing their teeth, using mouthwash, eating or drinking anything (other than water), chewing gum, smoking, etc., until the study is complete. exclusion criteria: * individuals on special diets (such as a very low carbohydrate diet) may be excluded * acute or debilitating medical condition * recent history of dental problems (gum disease, abcess, surgery) or current dental or mouth pain * current use of stimulants, hypnotics, tranquilizers, central nervous system active substances, and/or antibiotics. * use of products containing nicotine 24 hours prior to study

Keywords: sleep circadian rhythms circadian rhythm disorder
"clinical trials to enhance elders' oral health" ("teeth")

Conditions: Tooth Loss; Periodontal Disease; Tooth Decay

Summary: the purpose of this study is to determine if regular rinsing with chlorhexidine is effective as a long-term preventive method for reducing the incidence of tooth loss in low income older adults. the true end-point of the study is tooth loss after five years of regular rinsing with chlorhexidine or a placebo; surrogate endpoints are periodontal disease, root and coronal decay.

"teeth" is a double-blinded, randomized clinical trial, supervised by a data \& safety monitoring board, designed to provide unequivocal evidence regarding the impact of regular rinsing 0.12% chlorhexidine solution on tooth loss in low income, community-dwelling older adults who are irregular users of dental services. of the 1101 subjects enrolled in the study in seattle, wa and vancouver, b.c., one/half have been assigned to the active rinse condition; the other half to the placebo rinse which looks and tastes like the chlorhexidine rinse but does not have the active ingredient. subjects receive two bottles of rinse every six months; the first to be used daily for one month, the second weekly for five months. reminder calls are designed to help subjects maintain this rinse regimen. subjects return yearly to research clinics at each participating university, where they are examined by a dentist who is trained in clinical research methodology and calibrated annually. the purpose of these visits is to examine subjects for tooth loss (followed by contacts with extracting dentists to determine the dentist's reasons for extracting the tooth), pocket depth, recession, caries and restorations on root and coronal surfaces. interviews are also conducted annually with participants to assess health status, health behaviors, and oral health quality of life. a panoramic radiograph was taken at baseline of each subject and is to be done again at the five-year (final) yearly exam. these radiographs are used to confirm tooth loss and possible reasons for extractions

Eligibility criteria:
inclusion criteria: * age at entry 60-75 * four or more natural teeth * no preventive dental visits in the past 18 months * scores \> or = 60 on a measure of oral health self-efficacy (max possible=100) * willing to participate in a five-year study * willing to use rinses on a prescribed regimen and to return for yearly cleaning and exam appointments. exclusion criteria: * not having a phone at home for follow-up calls

Keywords: aging elderly periodontal disease dental caries fluoride antibacterial rinse chlorhexidine tooth mortality
a personalized behavioral intervention for older adults with musculoskeletal pain and sleep complaints

Conditions: Sleep; Pain

Summary: it is well recognized that physical activity/exercise is an effective intervention to improve sleep, reduce pain and improve function in a variety of pain conditions. traditional interventions to increase physical activity are challenging in older adults due to extensive staffing requirements and low adherence. the investigators plan to conduct a pilot trial in a cohort of older adults (without dementia) with both chronic musculoskeletal pain and nocturnal sleep complaints to test the effectiveness of a 12-week personalized behavioral intervention (compared to a control group) embedded within a smartwatch application in older adults. 27 cognitively intact elders were enrolled and randomly allocated to intervention or control group. participants in the intervention arm received a 2-hour in person education session, and personalized, circadian-based activity guidelines, with real time physical activity self-monitoring, interactive prompts, biweekly phone consultation with the research team, and financial incentives for achieving weekly physical activity goal. the control group received general education on physical activity in older adults and continue routine daily activity for 12 weeks.


Eligibility criteria:
inclusion criteria: * intact cognition * poor sleep quality * self-reported presence of pain * capacity for mild to moderate physical activity. exclusion criteria: * non-ambulatory or have severely impaired mobility, * visual or hearing impairment that interfered with assessments, and * an acute or a terminal illness * neuropathic pain
dual perfusion imaging for characterizing vascular architecture of brain lesions

Conditions: Brain Tumor; Brain Metastases

Summary: the objectives of the study are (1) to evaluate the feasibility of using a combined spin- and gradient- echo (sage) sequence in dynamic susceptibility contrast magnetic resonance imaging (dsc mri) and (2) to determine quantitative estimates of vessel density and size to differentiate between areas of radiation necrosis and tumor recurrence.


Eligibility criteria:
inclusion criteria: * diagnosed with a brain metastasis or primary brain tumour and who will undergo mri with contrast. exclusion criteria: * subject or subject's legally authorized representative is unable or unwilling to consent to the study. * subject with documented contrast medium injection contraindication due to severe kidney disease or allergy.
neurological outcomes of primary intracerebral haemorrhage

Conditions: Intracranial Hemorrhage, Hypertensive

Summary: the main objective of this study is to determine the one-year neurological outcome of patients admitted to an intensive care unit (icu) for a primary and spontaneous supratentorial intracerebral hemorrhages (ich).

ich represent a diagnostic and therapeutic emergency. ich account for 20% of strokes with a one-year mortality of more than 45% and an uncertain neurological outcome. for ich patients, the main initial challenge is to determine the long term neurological outcomes and adapt the therapeutic strategy. the majority of primary and spontaneous ich studies involve patients in stroke units. the study is an observational type 3 research with all the patients admitted in all the university hospital of grenoble alpes icus between july 2012 and july 2017 for a primary and spontaneous supratentorial ich

Eligibility criteria:
inclusion criteria: * admission in one of the four university hospital of grenoble alpes icus between july 2012 and july 2017 for primary and spontaneous supratentorial ich. * not opposed to participate in a research protocol (asked by phone call) exclusion criteria: * pediatric patient * infra-tentorials ich * no spontaneous ich (after head trauma) * secondary ich (anevrisum, arteriovenous malformation, tumor, hemorrhagic transformation, vascularitis) * persons referred to in articles l1121-5 to l1121-8 of the french public health code
impact of smart connected insulin pens on quality of life in dependent patients with diabetes using continuous glucose measurement

Conditions: Diabetes

Summary: insulin-treated diabetes in dependent or institutionalized patients is often poorly balanced and continuous glucose measurement is underused. the purpose of this tudy is to know how smart connected insulin pens and continuous glucose measurement can improve insulin therapy practice in dependent and/or institutionalized patients?

insulin-treated diabetes in dependent or institutionalized patients is often poorly balanced and continuous glucose measurement is underused. current practice and my experience in diabetes show a misuse of insulin therapy by caregivers at home and in institutions. studies on the elderly insulin-treated person living in institutions show, through continuous glucose measurement, frequent nocturnal hypoglycemia at 79%. the continuous measurement of glucose has also shown its interest in reducing hospitalizations for acute event and, permanently. a norwegian study shows that hypoglycemic treatments are too frequently prescribed in nursing homes. hospitalizations for severe hypoglycemia are often due to dose errors or unsupervised recommendations in people over 65 years. smart connected insulin pens have shown a benefit in the management of insulin therapy in patients living with type 1 diabetes, improving glycemic balance. study focuses on the identification of misuses of insulin therapy in dependent and/or institutionalized patients. a study of everyday life, we expect a decrease in dysfunctions in patients equipped with a continuous glucose measurement system and connected pens after advice given to their caregivers.

Eligibility criteria:
inclusion criteria: * older than 18 years patient with type 1 or 2 diabetes * treated with multiple insulin injections * equipped with a continuous glucose measurement system and smart connected insulin pens at least one month before * dependent on a health professional for treatment management. * subject informed of the study and not objecting to data collection. exclusion criteria: - patient refusing study.

Keywords: insulin practice dependent patient smart connected insulin pen
an observational study to evaluate the clinical effectiveness, quality of life, safety and tolerability of tocilizumab (tcz) in patients with rheumatoid arthritis (ra) in daily clinical practice

Conditions: Rheumatoid Arthritis

Summary: this observational trial will evaluate the effectiveness, the consistency of evaluation scores, quality of life, safety and tolerability of tcz administered subcutaneously (sc) in participants with ra in daily clinical practice.


Eligibility criteria:
inclusion criteria: * participants naive to tcz or who have received tcz sc treatment within 8 weeks prior to the enrolment visit can be included * participants in whom the treating physician has made the decision to commence tcz sc in accordance with the label and reimbursement criteria exclusion criteria: * participants who have received tcz \>8 weeks prior to the enrolment visit * participants who have previously received tcz sc * participants who have received treatment with any investigational agent within 4 weeks before starting treatment with tcz sc