Kornimate/medical-research-clean huggingface dataset:
character traits and stress in suspected prostate cancer

Conditions: Prostatic Diseases

Summary: it has previously been reported that men with prostate cancer are 1 ) reduced quality of life after diagnosis and treatment, 2 ) neuroticism increases the reduction in qol related to treatment side effects, and 3) often have very involved and active spouses who seems to have been handed over / taken over parts of the men's responsibility for their own health. we postulate herein a new hypothesis that the stress level is elevated when harbouring undetected prostate cancer. we will investigate whether those who are diagnosed with prostate cancer already in beforehand have an increased degree of masculine stress ( experience of not living up to their own perception of the ideal man ) and neuroticism in the typology. we will examine different personality and qol questionnaires for patients with elevated psa, and compare those whose clinical assessment later reveals prostate cancer, with three control groups: 1) men with elevated psa who are not diagnosed with prostate cancer, 2) men with normal psa treated for benign prostate enlargement and 3) patient with substantial risk of colorectal cancer (crc) who undergo colonoscopy, with regard to increased level of masculine stress and the personality trait neuroticism.

inclusion criteria: 1. men who are being referred as new urological outpatient and meet the following criteria: 1. wanted clinical examined because of elevated psa 2. not strong family history of prostate cancer 3. it is taken biopsy as part of routine investigation. 2. control groups: men being referred to urological / gastroenterological outpatient clinic, and which meet the following criteria: 1. urination complaints, normal psa, and study shows prostate size\> 40cc 2. or melena and cancer suspicion in colorectum 3. age\> 18 years and \<75 years outcome measures: together with statistician look for patterns / covariance in replies from those who are diagnosed with prostate cancer in the questionnaires personality evaluation adapted to normal population (neo-ffi), gender differentiated stress response questionnaire (mgrss) and questionnaires related to resilience, relationship and quality of life index, compared with the control groups.

Eligibility criteria:
inclusion criteria: 1. men who be referred a new urological outpatient and satisfy the following: * wanted examined because of elevated psa * not strong family history of prostate cancer * it is taken biopsy as part of routine investigation. 2. control group: men referred to urological outpatient clinic, and who satisfy the following * urination complaints * normal psa * examination shows prostate size\> 40cc 3. control group: men first time referred urological / gastroenterological outpatient clinic, and which satisfy the following -- symptoms that might indicate cancer suspicion in colorectum 4. age\> 40 years and \<75 years exclusion criteria: 1. known prostate cancer 2. reduced consent 4 familial occurrence of prostate cancer (one or more 1st degree relatives with cap)

Keywords: personality scores
dietary intervention for low free sugars in children with non-alcoholic fatty liver disease

Conditions: NAFLD; Low-free Sugar Dietary; Child Obesity

Summary: a 48-week dietary intervention program was conducted in children aged 5-14 years with a diagnosis of nafld, who were randomized into a low free sugar diet group and a regular diet group. the primary objective of this study is to determine whether a low free sugar dietary intervention program improves liver function, fasting glucose, fasting insulin, lipid profile and hepatic steatosis in children with nafld. the effects of the intervention will be analyzed and compared at weeks 12, 24 and 48.


Eligibility criteria:
inclusion criteria: * age: above 5 years old and below 14 years old; * guardian's consent and signing of informed consent; * who growth and development curves as the reference standard, overweight is defined as bmi greater than or equal to the 85th percentile of the who growth curves for children, and obesity is defined as bmi greater than or equal to the 95th percentile of the who growth curves for children; * liver imaging performance meets the diagnostic criteria of diffuse fatty liver. exclusion criteria: * age \ 14 years; * previous history of alcohol consumption; * non-cooperation with the study, inability to comply with the study treatment or study visit. * past or active hepatitis b virus infection; * past or active hepatitis c virus infection; * chronic or acute liver failure; * cholestasis; * hepatomegaly; * cystic fibrosis; * α1-antitrypsin deficiency; * autoimmune hepatitis; * tyrosinemia; * galactosemia or any recognized liver disease, any physical condition deemed by a physician to be unable to complete the trial. physical condition.
cd5789 (trifarotene) long term safety study on acne vulgaris

Conditions: Acne Vulgaris

Summary: multi-center, open-label, non-comparative safety and efficacy study with 52 weeks of treatment on the face and trunk for acne vulgaris.

to determine the safety and efficacy of cd5789 (trifarotene) 50 µg/g cream in the long-term treatment (up to 52 weeks) of subjects with acne vulgaris. efficacy will be evaluated as a secondary objective.

Eligibility criteria:
inclusion criteria: * the subject has a facial acne severity grade of iga grade 3 (moderate) at screening and baseline visits. * the subject has a minimum of 20 inflammatory lesions and 25 non-inflammatory lesions at screening and baseline visits on the face. * exclusion criteria: * the subject has severe forms of acne (acne conglobata, acne fulminans) or secondary acne form (chloracne, drug-induced acne, etc.). * the subject has more than 1 nodule on the face at screening and at baseline visits. * the subject has any acne cyst on the face at screening and at baseline visits.

Keywords: acne vulgaris safety face trunk
fresh corneal lenticule implantation in macular corneal distrophy with relex smile surgery

Conditions: Macular Corneal Dystrophy

Summary: the aim of the study is to examine the effect of fresh corneal lenticule implantation as allogenic graft taken from myopic patients to implanted in patients with macular corneal dystrophy using visumax femtosecond laser smile module surgery.

macular corneal dystrophy is a severe form of stromal corneal dystrophy characterized by bilateral cloudy regions within hazy stroma and eventually severe visual impairment. most cases of mcd are caused by mutations in the chst6 gene encoding a protein involved in the production of keratan sulfate, which plays a role in the maintenance of corneal transparency. according to biomechanical instability of corneal metabolism (abnormal increase collagenase activity, decrease proteinase inhibitors, excessive premature keratocyte apoptosis, increase cytokine binding) at corneal dystrophies. fresh corneal lenticule and autologous serum contains live stem cells that produce keratocytes, collagen fibers, extracellular matrix which contribute to the regeneration of the cornea, and all this results at increasing of corneal transparency and visual acuity in patients with corneal macular dystrophy.

Eligibility criteria:
inclusion criteria: * indications for penetrating keratoplasty * low transparec of corneae * low visual acuity exclusion criteria: * active anterior segment pathology * previous corneal or anterior segment surgery * any infection
effect of core stability and sensorimotor training exercises on postural stability post lower limb burn

Conditions: Burns

Summary: the purpose of the study is to determine the effect of core stability and sensorimotor training exercises on postural stability post lower limb burn.

the need for this study develops from the lack of information in the published studies about the effectiveness of core stability exercises and sensorimotor training on the rehabilitation of burned patients. severe burn injuries, particularly those encompassing over 20% of the total body surface area (tbsa), trigger elevated catabolism and hypermetabolic responses in adult and pediatric burn patients. this wide spectrum of pronounced effects stemming from the hypermetabolic response and catabolism includes substantial muscle mass depletion, reduced muscle strength and endurance, hindered wound healing, impaired sensory perception, constrained ambulatory capacity, postural instability, and diminished functional mobility. core stability exercises improve neuromuscular system performance that causes the optimal lumbar-pelvic -hip chain mobility and good acceleration and deceleration, appropriate muscular balance, proximal stability and good function. sensorimotor training exercise emphasizes postural control and progressive challenges to the sensorimotor system to restore normal motor programs in patients. the proprio sensory system helps the motor system to maintain equilibrium on a reflex, automatic basis. in response to a sudden load, "the muscles will respond rapidly to stabilize the body, i.e., they will try to maintain balance and posture. the present study is designed to investigate the effect of core stability and sensorimotor training exercises on postural stability in burned patients.

Eligibility criteria:
inclusion criteria: * patients are both males and females. * their age will range from (20-50) years. * patients will suffer from lower limb second degree burn (partial thickness of thermal injury). * total body surface area (tbsa) for the burns will be ranged from 20% to 35% . * patients will begin the training program after complete wound healing. * patients will be given their informed consent. exclusion criteria: * patients who had an open wound at or near treatment site. * patients who had chemical or electrical burn. * musculoskeletal disorders that will impair performance during training and tests. * uncontrolled cardiovascular or pulmonary diseases . * neurological and renal disorders. * metabolic or vascular disease with a neurological component such as diabetes. * malignant conditions. * psychiatric illness, severe behavior or cognitive disorders. * uncooperative patients. * pregnancy.
frequency and origin of dysnatremias in the emergency department

Conditions: Hyponatremia; Hypernatremia

Summary: hypo- and hypernatremia are the most frequent electrolyte disorders found in hospitalized patients. the increasing use of diuretics and other medications influencing the water and sodium homeostasis potentially lead to a rise in the prevalence of the electrolyte disorders. only little data is available on the frequency and the mechanisms leading to hypo-/hypernatremia. thus, the investigators aim to a.) determine the frequency of hypo- and hypernatremia in the emergency department of a large tertiary university hospital and b.) explore the mechanisms leading to the development of dysnatremias by detailed clinical and laboratory examinations.


Eligibility criteria:
inclusion criteria: * serum sodium below 135 mmol/l (i.e. hyponatremia); serum sodium exceeding 145 mmol/l (hypernatremia) exclusion criteria: * patients below age 18 years; patients declining study participation.

Keywords: sodium hyponatremia hypernatremia emergency department
a phase 2 double-masked study of vvn539 in subjects with elevated intraocular pressure

Conditions: Glaucoma, Open-Angle

Summary: this is a prospective, parallel-comparison, multi-center, double-masked, randomized, vehicle-controlled dose-response study assessing the safety and ocular hypotensive efficacy of vvn539 in subjects with poag or oht. three different dosing regimens (once a day \[q.d.\] in the morning, q.d. in the evening and twice a day \[b.i.d.\]) will be tested for 7-9 days, each.


Eligibility criteria:
inclusion criteria: * 18 years of age or older. * diagnosis of primary open-angle glaucoma or ocular hypertension in both eyes that are untreated, or if treated, in the opinion of the investigator are well controlled on 2 or fewer ocular hypotensive medications prior to visit 1. * unmedicated intraocular pressure of ≥ 22 mm hg and ≤ 36 mm hg in the study eye, with no more than 5 mm hg inter-eye difference at 08:00am and 10:00am at visit 2. * corrected visual acuity in each eye +1.0 or better by early treatment diabetic retinopathy scale in each eye (equivalent to snellen 20/200) exclusion criteria: * known hypersensitivity to any kinase inhibitors, any excipient or preservative of the formulation or to topical anesthetics or fluorescein. * unmedicated iop of \> 36 mm hg in either eye at any time point at visit 2.
safety, tolerability, pharmacokinetics and efficacy of eyp001a in patients with nonalcoholic steatohepatitis (nash)

Conditions: Non-alcoholic Steatohepatitis

Summary: the purpose of this study is to assess the effects of eyp001a (vonafexor) with respect to safety, tolerability, pharmacokinetics and on markers of liver inflammation in patients with nash

this is a 2-part, randomized, double-blind, multicenter, placebo-controlled study to evaluate the safety and efficacy of vonafexor in patients with nash who likely have stage f2 to f3 fibrosis at approximately 50 global clinical sites. overall, approximately 114 eligible patients will be enrolled: 24 patients in part a (safety run-in cohort), followed by 90 patients in part b. in part a, 24 patients will be randomized on day 1 to 1 of 4 parallel treatment groups: 100 mg vonafexor twice daily (bid), 200 mg vonafexor once daily (qd), 400 mg vonafexor qd, or placebo bid. in part b, 90 patients will be randomized on day 1 to 1 of 3 parallel treatment groups: 100 mg vonafexor qd, 200 mg vonafexor qd, or placebo qd.

Eligibility criteria:
inclusion criteria: * written informed consent * suspected diagnosis of nash, evidenced by elevated alanine aminotransferase (alt), liver stiffness compatible with f2 or f3 fibrosis and liver fat content (lfc) ≥10% as measured by mri * women of childbearing potential and male patients with female partners must agree to use a dual method of contraception exclusion criteria: * evidence of worsening liver injury * previous diagnosis of other forms of non-nash liver disease * use of vitamin e, glitazones, glucagon-like peptide-1 receptor agonists, ursodeoxycholic acid, or obeticholic acid within 90 days prior to screening * history of cirrhosis or liver decompensation * known history of alcohol abuse or daily heavy alcohol consumption * pregnant or breastfeeding women * type 1 diabetes mellitus and uncontrolled type 2 diabetes mellitus * patients with contraindications to mri imaging

Keywords: eyp001 (vonafexor) liver diseases non-alcoholic fatty liver disease non-alcoholic steatohepatitis nash
effect of polyphenol supplementation on hepatic steatosis and vascular compliance

Conditions: Obesity, Childhood; Hepatic Steatosis; Intimal Hyperplasia

Summary: the main objective is to study the effect of polyphenol supplementation on hepatic steatosis as measured by hepatic ultrasound, hepatic magnetic resonance imaging and on intima-media thickness and vascular elastography in obese adolescents known for hepatic steatosis as diagnosed by liver biopsy

1. evaluate the feasibility of a larger, open-label, randomized, controlled trial on the effects of polyphenol supplementation: recruitment, compliance to polyphenol supplementation and the visit roadmaps duration of the radiological exams and participants' satisfaction and point of view on the experience. test the relevance of using a food diary. test the effectiveness of the data collection procedure during the visits. explore the obstacles encountered while performing the radiological exams and the rate of adverse events (ae). calculate the sample size of the future randomized clinical study 2. effects of polyphenols imt and vascular elastography. anthropometric measurements, insulin resistance, inflammation, lipid/lipoprotein profile, gut microbiome and liver function 3. evaluated different imaging modality for steatosis different imaging modalities will be compared between children

Eligibility criteria:
inclusion criteria: * aged 12 to 18 years * bmi percentile \> 85th for age and sex * diagnosis of hepatic steatosis on imaging (ultrasound or mr). * diagnosis of hepatic steatosis, nash, or fibrosis on liver biopsy. * elevated alanine aminotransferase (alt) enzyme level. * index of hepatic steatosis 8xalt/ast + bmi (+2 for girls) \> 30. exclusion criteria: * known chronic systematic diseases * any other serious conditions which, according to the doctor's judgment, would prevent compliance and safe participation in the study until completion. exclusion criteria to be validated when contacting the participants and their parents/tutors: * being pregnant. * taking all kinds of prescription or over-the-counter natural health products/natural supplements/vitamins on an ongoing basis or within the next four months, excluding vitamin d. * weight loss of 5% to 10% of the usual weight in the last six months before recruitment or weight change of 5% in the last three months. * alcohol consumption \> two drinks/day or \> one day/week. * known peanut allergy and/or to the medicinal ingredients contained in the active polyphenol supplement: elderberry, haskap, black chokeberry, blueberry, blackcurrant. * any contraindications for mri.
optimizing postpartum contraception in women with preterm births

Conditions: Method of Contraception; Preterm Birth Recurrence

Summary: the purpose of this study is to examine the effectiveness of focused family planning counseling on the uptake and continuation of highly effective contraceptive methods (defined as the intrauterine device, implant, and both male and female sterilization methods including vasectomy, tubal ligation and essure) during the postpartum period in women who have recently experienced a preterm delivery. the investigators hypothesize that women with a recent preterm birth (ptb) will be more likely to initiate and continue using a highly effective method of contraception when provided with focused family planning counseling.


Eligibility criteria:
inclusion criteria: * women who deliver a premature infant that is between the gestational ages of 24 weeks 0 days and 36 weeks 6 days at our institution. exclusion criteria: * women who have delivered via cesarean section and have also had a sterilization procedure at the time of the cesarean section.
postoperatively treated patients with lower limb fracture with or without an anti-gravity treadmill

Conditions: Muscle Degeneration

Summary: the presented study is designed to prove efficacy of the anti-gravity treadmill (alter g®) compared to a standard rehabilitation protocol in patients with tibial plateau or ankle fractures with six weeks of partial weight bearing.


Eligibility criteria:
inclusion criteria: * patients with a postoperative partial weight bearing after tibial plateau or ankle fracture. * man and woman of an age between 18 and 65 exclusion criteria: * body weight more than 100kg * serious illness or poor general health as judged by physician that may influence the rehabilitation * open fractures (\>1° according to gustilo and anderson) * surgical site infection * pregnancy * neuromuscular disorders or preexisting muscle atrophy.

Keywords: rehabilitation, anti-gravity treadmill
oral mucositis and quality of life with a mucosa topical composition in head & neck cancer patients.

Conditions: Oral Mucositis; Quality of Life; Mucositis; Pain; Speech; Saliva; Radiation Toxicity; Chemotherapeutic Toxicity

Summary: proms questionnaires seem to be an effective tool to obtain a greater knowledge of the physical and emotional state of patients. despite this, few studies have been performed using patient reported outcomes in head \& neck (h\&n) cancer patients during and after treatment. the use of a novel topical mucosa composition (saliactive®) is studied along the use of questionnaires.

this study analyses the severity of oral mucositis of h\&n cancer patients along the first 6 weeks of radiotherapy with or without chemotherapy (phase 1). phase 2 evaluates quality of life in a pool of h\&n cancer patients 6 months after cancer treatment is completed. quality of life of patients is analysed before (baseline) and after 1 month period of use of the tested composition (saliactive®) begining 6 months after oncological treatment completion. during cancer treatment (phase 1), mucositis may affect the course of therapy and long-term survival, while after treatment (phase 2) chronic pain, xerostomia, dysphagia and speech limitations between others are behind anxiety and poor quality of life. the who oral mucositis scale together with a structured qualitative questionnaire to recover patient reported symptoms are used during phase 1. a validated quality of life questionnaire described by the university of washington, is chosen for phase 2 evaluation. oral mucosa management is homogenized both during acute and chronic phase with the use of a composition (saliactive®) which comprises olive oil, betaine and xylitol delivered in the form of a topical non-rinsing gel.

Eligibility criteria:
inclusion criteria: * patients with diagnose of head \& neck cancer that are going to receive cancer therapy (radio and/or chemotherapy). exclusion criteria: * patients taking drugs for xerostomia.

Keywords: oral mucositis cancer therapy toxic effect cancer support pain ulcers treatment interruptions oral mucosa radiotherapy chemotherapy