Kornimate/medical-research-clean huggingface dataset:
gestational diabetes mellitus and implications for cardiovascular disease risk

Conditions: Gestational Diabetes Mellitus

Summary: the purpose of this research study is to look at whether there are differences in blood vessel function, risk for developing diabetes (high blood sugar), lipid (blood fat) levels, and levels of other blood markers in women who have had a pregnancy complicated by diabetes as compared with women who have had a normal pregnancy.


Eligibility criteria:
inclusion criteria: * healthy women of self-identified african descent (black) and european (white) ancestry * 18-40 years of age * regular menstrual cycles * 5 or less years postpartum * have either a normal or a gdm index pregnancy history * are in good health free of thyroid, cardiac, or renal disease exclusion criteria: * if you are pregnant * if you are lactating

Keywords: gestational diabetes mellitus cardiovascular disease risk heart disease risk
removing barriers: community partnering for innovative solutions to the opioid crisis

Conditions: Opioid Use Disorder; Alcohol Use Disorder; Health Risk Behaviors; Criminal Behavior; Housing Problems; Overdose of Opiate

Summary: the opioid epidemic has become one of america's deadliest crises, surpassing car crashes, firearms, and hiv/aids as a leading cause of death for americans under fifty years of age. people trying to recover from opioid-use disorder face many obstacles. obstacles such as minor legal problems (e.g., arrest warrants for failure to pay a fine, failure to appear in court, or late child support payments) can undermine the stability needed to overcome opioid dependence. outstanding legal obligations make it difficult to find jobs and to secure housing. they can result in removal from treatment programs as well as incarceration. resolving these legal problems requires coordination, organization, preparation, travel, and time-expectations that may be problematic for many people in the early stages of recovery. technology has the potential to make resolving these legal problems much easier. online platform technology is now available that can guide people in recovery through the resolution of many legal problems at no cost and without an attorney, potentially doing so quickly, remotely, and at any time of day. this study of individuals in treatment in michigan tests whether resolving outstanding legal issues improves drug treatment outcomes. the research also examines whether and to what extent resolving legal issues supports family reunification, reduces future criminal behavior, and improves access to jobs and housing for clients in treatment for opioid use disorder. a randomized controlled trial (rct) is used to determine the effects of resolving legal issues on these outcomes. for identification, the investigators leverage the random assignment of legal services to treatment center clients, along with the random assignment of clients to treatment centers by birth month. we assemble a novel longitudinal dataset of hundreds of clients in treatment for substance use disorder and link these clients to several administrative datasets and qualitative data, which allows for measurement of: (1) substance use behaviors and (2) justice-system involvement, including civil and criminal legal system encounters. this study also uses linked client and administrative data to research the population in opioid treatment centers, follow-up behaviors, and whether the consequences of providing no-cost legal services differ by client background. findings from this research will improve america's understanding of the acute socio-legal needs faced by those experiencing opioid use disorder and provide recommendations to help target resources toward the areas that best support long-term abstinence from opioids and other drugs.


Eligibility criteria:
inclusion criteria: \*receiving substance use disorder treatment services exclusion criteria: \*not receiving substance use disorder treatment services
web-based daily care training of children with cerebral palsy

Conditions: Cerebral Palsy

Summary: purpose:effect of web-based daily care training on the quality of life of caregivers of children with cerebral palsy. study design: single-blind clinical trial. study population: caregivers of children with cerebral palsy. inclusion criteria: caregiver -mother of a child with cerebral palsy who spent most time on child care- children with cerebral palsy aged 4 to 12 years old living in alborz province that clinical diagnosis of cerebral palsy registered in their clinical records. moderate and severe cerebral palsy (gross motor function levels 3 to 5). caregiver have facilities and basic knowledge of using internet (declared access to the internet at least one hour a week). exclusion criteria: taking care of two or more children with disability. participated in previous face to face training programs. sample size: 100. intervention: web-based daily care training. intervention time: 12-week. outcome of the study: the quality of life of caregivers

step1: web development and design 1. development of educational content (4 weeks) 2. create a paper version of the site (2 weeks) 3. create a web-based version of the site (4 weeks) 4. pilot study (6 weeks) step 2: rct (12 weeks)

Eligibility criteria:
inclusion criteria: * caregiver_ mother of a child with cerebral palsy who spent most time on child care children with cerebral palsy aged 4 to 12 years old living in alborz province that clinical diagnosis of cerebral palsy registered in their clinical records * moderate and severe cerebral palsy (gross motor function levels 3 to 5) * caregiver have facilities and basic knowledge of using internet (declared access to the internet at least one hour a week) exclusion criteria: * taking care of two or more children with disability * participated in previous training programs
functional magnetic resonance imaging study in schizophrenia patients and correlation with cognitive impairments

Conditions: Schizophrenia; Cognitive Impairment

Summary: 1. comparison of functional activity at different brain areas related to different cognitive domains e.g. memory, visuospatial abilities, executive functions, attention, concentration, language, orientation in schizophrenia to healthy subjects. 2. correlation with resting functional activity at brain areas with clinical deterioration in cognitive functions.

schizophrenia represents a multifaceted clinical challenge. patients' outcome is still highly heterogeneous and poor. cognitive impairment, a central feature of the illness is present in over 80% of patients with schizophrenia, is a main functional disability. currently available antipsychotics have only limited effects on cognition and side effects may even aggravate some deficits. so far, pharmacological options for cognitive deficits in schizophrenia are unsatisfactory due to either limited efficacy or tolerability concerns. understanding the quality, quantity of brain changes could cover patterns of potential therapeutic relevance, guiding treatments. understanding the pathophysiology of impaired cognition in schizophrenia and developing effective treatment for cognitive symptoms are major unmet challenges for contemporary biomedical research. briefly, deficits in speed of processing have been correlated with a reduced temporal lobe volume and increased ventricular size. attention impairments were correlated with structural alterations within the frontal and temporal lobes and with widespread reduced volume of subcortical regions . decreased working memory was correlated with reduced frontal and temporal lobe volumes and cortical thickness while language and memory deficits were correlated with hippocampal volume loss. impaired visuspatial and memory correlated with hippocampal volume loss. deficits in reasoning and problem solving, including higher-order executive functions, were also associated with a reduced the dorsolateral prefrontal cortex volume. among different neuroimaging modalities, functional magnetic resonance imaging (fmri) predominates in system-level connectomic studies. particularly, the task-free version-known as resting fmri-is better tolerated by clinical populations, and circumvents the need for stringent subject compliance. today, fmri features are being rigorously examined to identify potential biomarkers for diagnosis and prognosis of different brain disorders

Eligibility criteria:
inclusion criteria: * diagnosis according to diagnostic and statistical manual of mental of mental disorders -5 (dsm-5) and confirmed by the structured clinical interview for dsm-5 (scid -i) exclusion criteria: * history of head injury. * history of intellectual disability or neurological diseases e.g. cerebrovascular stroke, dementia parkinsonism, etc. * history of alcohol and/or substance abuse in the previous six months. * inability to provide informed consent.

Keywords: functional mri schizophrenia
low dose corticosteroid infusion in vasoplegia after cardiac surgery (cortivas-cs)

Conditions: Vasoplegia; Cardiac Surgery

Summary: vasoplegia is an important determinant for adverse postoperative outcome and is observerd in 5% to 54% of patients undergoing cardiac surgery using cardiopulmonary bypass (cpb). postoperative vasoplegia is defined as a state with low systemic vascular resistance despite a normal or high cardiac output, and the need for vasopressor therapy. steroids attenuate the inflammatory response to cardiopulmonary bypass,but their effect on clinical outcomes is uncertain. this is a double-blinded, randomized, clinical trial designed to determine the efficacy of low dose corticosteroid infusion in vasopressor free-days in vasoplegia after cardiac surgery.


Eligibility criteria:
inclusion criteria: * cardiac surgery with cardiopulmonary bypass * norephinerine treatment in icu with dose great or equal than 0,1 mcg/kg/min to maintain or restore a map over 70 mmhg for at least 30 minutes within 24 hours after surgery exclusion criteria: * preoperative vasopressor use (within 72 hours prior to surgery) * preoperative steroids use (within 7 days prior to surgery) * presence of ventricular assist device other than intraaortic ballon pump * transplant procedures * emergency procedures * aortic repairs * congenital procedures * endocarditis * bacterial or fungal infection in the preceding 30 days * active neoplasia * pregnancy * recent history of gastrointestinal bleeding * allergy or intolerance to steroids * participation in other study

Keywords: vasoplegia cardiac surgery steroids
bma and dynamic nomogram for survival prediction in patients with crc

Conditions: Colon Cancer; Model Disease

Summary: this project will examine the outstanding statistical techniques for predicting the survival of patients with colorectal cancer (crc) (colorectal neoplasia database). the motivating clinical question that led to proposing this project is based on the general assumption that: "right-sided colorectal cancer (crc) has worse survival than left-sided crc." the question is, which aspects of the patient's characteristics are responsible for this difference? this led us to bma model selection and provide a clinician-friendly online nomogram.

translational statistics merges biostatistics and clinical research to communicate research findings effectively. nomograms, graphical representations integrating independent prognostic factors, are valuable tools in colorectal cancer (crc) research. bayesian models for variable selection in survival outcome prediction offer advantages through bayesian model averaging (bma). this study aimed to utilise bma for variable selection and develop a clinician-friendly online dynamic nomogram for survival prediction. a retrospective study utilised the cabrini monash colorectal neoplasia database, including colon cancer patients who underwent surgery. data on demographics, perioperative risks, treatment details, mortality, morbidity, and survival were collected. bma was employed for bayesian variable selection to identify effective risk factors for survival prediction. sensitivity analyses using cox-lasso and imputation of missing data were performed. prognostic online dynamic nomograms were constructed using selected risk factors and the r-package dynnom.

Eligibility criteria:
inclusion criteria: in this study, patients were included based on specific selection criteria: being 18 years old or older, having a diagnosis of colon adenocarcinoma (or post polypectomy of the same condition), and having undergone surgery for colon cancer. exclusion criteria: patients with rectal cancer, neuroendocrine tumours, lymphomas and those who underwent trans-anal surgery were not included in the study.

Keywords: colorectal cancer; translational statistics; online dynamic nomogram; bayesian variable selection; survival prediction
ursodeoxycholic acid in bariatric surgery

Conditions: Non-alcoholic Fatty Liver Disease; Morbid Obesity

Summary: in an open-label trial, 20 otherwise healthy morbidly obese patients scheduled for bariatric surgery will be administered 20 mg/kg/day ursodeoxycholic acid for three weeks until the day before surgery. the maximum dose will be 3 g/day. twenty other patients will serve as controls. serum from days 1 and 21 will be analyzed for routine liver tests, bile acids, a complete lipid profile including fa and in addition for 7α-hydroxy-4-cholesten-3-one and fibroblast growth factor 19 (fgf-19), markers for bile acid synthesis its intestinal stimulation. for the evaluation of insulin resistance and possible pre-diabetes, plasma will be taken for the estimation of homeostasis model assessment (homa) index and oral glucose tolerance test (ogtt) will be performed at days 1 and 21. at surgery, a liver biopsy (0.5-1 g) and a white adipose tissue (wat) specimen (1 cm2) will be taken and immediately frozen in liquid nitrogen for messenger ribonucleic acid (mrna) and protein preparation for quantitative real-time polymerase chain reaction (rt-pcr) and western analysis, respectively, histopathological non-alcoholic fatty liver disease (nafld) grading, and measuring of hepatic and white adipose tissue (wat) lipase activity. in all patients at randomization, abdominal ultrasound will be performed for the detection of nafld and gallstones and a blood sample will be taken for the analysis of polymorphisms of hepatic lipid synthesis, storage, fatty acid (fa) oxidation and export genes. six month after operation, homa, ogtt and abdominal ultrasound will be repeated.


Eligibility criteria:
inclusion criteria: * bmi ≥ 35 kg/m2 * patients eligible to bariatric surgery * patients should have given their written consent to participate in this study exclusion criteria: * chronic liver disease other than nafld (viral hepatitis, autoimmune liver disease, hemochromatosis, homozygous alpha1-antitrypsin deficiency and wilson disease) * partial ileal bypass * inflammatory bowel disease * uncontrolled diabetes mellitus (fasting blood glucose \> 6.7 mmol/l), hypothyroidism or hyperthyroidism, or other significant endocrine disease. * a subject who is euthyroid on a stable replacement dose of thyroid hormone is acceptable provided the tsh is within normal range. * other serious disease * known hypersensitivity to ursodeoxycholic acid * patients who will not comply with the protocol.

Keywords: ursodeoxycholic acid fatty liver disease morbid obesity bariatric surgery nafld
efficacy and safety study of botox® compared to topiramate for the prevention of chronic migraine in adults

Conditions: Migraine Disorders

Summary: this study will evaluate the efficacy, safety and tolerability of prophylactic (preventative) treatment with botox® (onabotulinumtoxina) compared to topiramate in adults with chronic migraine.


Eligibility criteria:
inclusion criteria: * history of chronic migraine * more than 15 headache days in a 28 day period (headaches that last more than 4 hours and/or require treatment with prescription medication). exclusion criteria: * taking opioid-containing products for acute headache treatment more than 8 days during a 28-day period * previous treatment with botulinum toxin of any serotype for any reason * previous treatment with topiramate * on a ketogenic diet (high in fat, low in carbohydrates) * history of acute myopia or increased intraocular pressure * diagnosis of myasthenia gravis, eaton-lambert syndrome, amyotrophic lateral sclerosis or any other significant disease that might interfere with neuromuscular function * acupuncture, transcutaneous electrical stimulation (tens), cranial traction, dental splints for headache, or injection of anesthetics/steroids in the 4 weeks prior to screening.
evaluation of the relationship between obstetric comorbidity index and obstetric quality of recovery score

Conditions: Quality of Life; Obstetric Complication; Cesarean Section Complications; Comorbidities and Coexisting Conditions; Obstetric Anesthesia Problems

Summary: the goal of this prospective observational study is to learn about the correlation between obstetric comorbidity index and obstetric quality of recovery score in pregnant patients who undergo cesarean section. the main question aims to answer are: * are there a correlation between the obstetric comorbidity index and the obstetric quality of recovery score? can we predict the postoperative quality of recovery by calculating the obstetric comorbidity index before delivery? * what is the relationship between these scores with the type of anaesthesia given? participants will answer an 11-question assessment scale to evaluate their recovery of quality in the postpartum period.

after the approval of the ethics committee and the written informed consent of the patients, the patients who are meeting the criteria of inclusion will be included in the study. the demographic data, type of anaesthesia, intraoperative haemorrhage, length of hospital stay and intensive care unit stay(if applicable), the urgency category of the cesarean section, and complications will be recorded. patients will be evaluated with obstetric quality of recovery assessment score on postpartum 1st and 2nd days

Eligibility criteria:
inclusion criteria: * pregnant women who are admitted for cesarean section \> 18 years old * speaking turkish or english * agreeing to participate in the study exclusion criteria: * pregnant women \< 18 years old * can not speak turkish or english * not agreeing to participate in the study

Keywords: obstetric comorbidity index obstetric quality of recovery cesarean section obstetric anaesthesia
effectiveness of a cognitive training program (umam method) in elderly people without dementia

Conditions: Age-Related Memory Disorders

Summary: the study is oriented to analyze the effectiveness of a cognitive training method (umam) on cognitive functions, subjective memory and mood state in elderly people without dementia. on the other hand, the study aims to examine whether variables such as cognitive reserve (e.g. educational level), apoe genotype and intracranial volume are related to increased benefit after the intervention. the researchers hope to find that greater cognitive reserve, not having the apoe allele ε4, and a greater volume of memory-related brain areas, are associated with better outcomes after the cognitive intervention.


Eligibility criteria:
inclusion criteria: * being over 60 years old. * having a global cognitive performance \> 23 in the mini mental state examination test. * having no history of neurological or serious psychiatric disorders (severe psycho-affective disorders and psychosis or other psychiatric disorders like alcoholism). exclusion criteria: * chronic use of anxiolytics. * chronic use of neuroleptics. * chronic use of anticonvulsants. * having hearing or vision impairments that would preclude testing. * magnetic resonance imaging (mri) contraindications.

Keywords: cognitive training memory failures apoe brain volume cognitive reserve
impact of interprofessional training and co-ordination on early identification and proactive approach to end-of-life situations in the context of primary care

Conditions: Interprofessional Relations; End-of-life Situations

Summary: more than 300,000 people die each year in france from a disease that may require palliative care. nevertheless, only a small proportion of these patients are able to access this care, in particular because of a too late identification. while several factors may hinder access to specialized palliative care resources, one of the major barriers to the initiation of palliative care, and particularly to the implementation of quality end-of-life care, remains the failure to recognize that patients with advanced chronic illness are actually approaching the end of their lives. however, it is now clearly established that early integration of palliative care in the care of people living with a serious, incurable and progressive disease: * has an impact on the quality (and sometimes the expectation) of life of these people, * avoids aggressive treatments and unplanned hospitalizations, * is associated with lower health costs than other end-of-life patients. primary health care providers have a major role to play in facilitating access to palliative care, but their practice has been hampered in our country by the fragmented and poorly coordinated nature of primary care and negligible in terms of training. however, they remain the first contact of the patients with the system of care, and are also structuring for the continuation of the patient's journey within the health system. the first hypothesis is that the work of genuine interprofessional primary care teams in multi-professional health centers (msps), coupled with adequate training in the use of simple tools, can contribute to the early identification of patients approaching end of life, to meet their palliative care needs. however, various european programs (gold standards framework in the uk, necpal in catalonia, radpac in the netherlands) have shown that identification alone is not enough to increase access to specialized palliative care. the second hypothesis is that it must be articulated for this with a training of the professionals to carry out conversations of anticipated planning of the care with their patients.


Eligibility criteria:
inclusion criteria: * being a multi-professional health care home (msp) * at least one specialized palliative care resource available in the msp territory (usp, emsp, palliative care network) exclusion criteria: * health centers, group medical practices, clinics * less than 3 general practitioners (gps) and / or absence of nurses (fdi) within the msp