Kornimate/medical-research-clean huggingface dataset:
effectiveness of a mindfulness and compassion intervention for pregnant women and their partners for the prevention of stress and depression during pregnancy and breastfeeding

Conditions: Pregnancy, Childbirth and Postpartum

Summary: the aim of this study is to assess a mindfulness and compassion group intervention for pregnant women and their partners (8 weeks) for the prevention, reduction and treatment of stress, negative affect and depression in pregnancy and breastfeeding. this group intervention will also be compared with a treatment as usual (tau) group consisting in a childbirth education class taught by the health center midwife. the principal hypothesis is that the mindfulness and compassion intervention will be more effective than tau.

the aim of this study is to assess a mindfulness and compassion group intervention for pregnant women and their partners (8 weeks) for the prevention, reduction and treatment of stress, negative affect and depression in pregnancy and breastfeeding. there will be two groups: 1. a face to face mindfulness and compassion intervention for pregnant women in their second trimester of pregnancy and their partners in group format (8 weeks) based in the mindfulness based childbirth and parenting program from nancy bardacke. this group will also receive in their third trimester of pregnancy the childbirth education classes taught by midwives (6-8 weeks) that every pregnant woman normally attends to in the national health care system in spain (tau). 2. a control group that will receive only the childbirth education class by midwives (tau) group consisting in a childbirth education class taught by the health center midwife at the third trimester of pregnancy. each group will be composed of 60 participants with a total sample of 120. the principal hypothesis is that the mindfulness and compassion intervention will be more effective than tau in the decrease of stress, negative affect and depression and in the increase of positive affect during pregnancy and breastfeeding. the differences between the intervention and control group will be analyzed. finally, a qualitative study will be conducted.

Eligibility criteria:
inclusion criteria: * be at least 18 years old * willingness to participate in the study and signing informed consent * ability to understand and write spanish. * women will be in their 6 to 25 weeks of pregnancy. * all women eligible will be accepted with our without their partner. exclusion criteria: * any diagnose of disease that may affect central nervous system (brain pathology, traumatic brain injury, dementia, etc.), * other psychiatric diagnoses or acute psychiatric illness (substance dependence or abuse, history of schizophrenia or other psychotic disorders, eating disorders, etc.), * any medical, infectious or degenerative disease that may affect mood, presence of delusional ideas or hallucinations consistent or not with mood, and suicide risk * currently taking psychopharmacological medication or under psychopharmacological treatment.

Keywords: mindfulness compassion depression during pregnancy and postpartum prevention stress
self-obtained ultrasound scans for measurement of cervical dilation and effacement in labor

Conditions: Cervical Dilation

Summary: this is a pilot study to test the accuracy and comfort of self-directed ultrasound imaging of cervical dilation and effacement in pregnant women undergoing induction of labor. the study will assess correlation of cervical measurements between self-directed imaging and experienced provider digital cervical examinations.

the primary objective will assess correlation of cervical measurements with gold standard of provider digital cervical examinations and self-obtained transperineal and transvaginal images. experienced providers performing digital cervical examinations will be blinded to ultrasound images and measurements. the maternal-fetal medicine subspecialist interpreting the ultrasound images will be blinded to patient details and will document ultrasound measurement of cervical dilation of the internal cervical os as the mean of anterior-posterior and transverse measurements and cervical length. 2-d ultrasound images and cine clips will be obtained at up to five different time points during the induction of labor. as as secondary objective, participant discomfort and anxiety will be measured following the initial set of cervical measurements using the visual analog scale and six-item state-trait anxiety inventory.

Eligibility criteria:
inclusion criteria: * pregnant females age 18 years or older * third trimester of pregnancy with a singleton fetus (gestational age \>28 weeks) * pre-gestational body mass index \<40 * scheduled for induction of labor * eligible for induction of labor based on current birth center guidelines * intact membranes when presenting for induction of labor exclusion criteria: * history of prior cervical loop electrosurgical excisional procedure or cold knife conization * cerclage placement during current pregnancy * positive covid-19 test within 7 days of admission for induction of labor * fever \> 38.0 c at time of admission for induction of labor

Keywords: cervical effacement cervical dilation labor pregnancy
second-line therapy

Conditions: Treatment Failure of Second-line ART in Asian HIV-infected Children

Summary: this study will help identify which arv candidates should be prioritized for pediatric use in resource-limited settings

children in resource-limited settings are increasing experiencing treatment failure, as defined by virologic, immunologic, and/or clinical criteria. there are few studies of hiv resistance mutations in children failing first line nnrti therapy in resource limited settings. the emergence of treatment failure and drug resistance in children on art emphasizes the urgency for developing evidence-based second-line and salvage treatment strategies. pediatric treatment is complicated by a number of factors, including having fewer numbers of arvs approved by drug safety agencies and the lack of pediatric formulations. this further shortens the list of available second-line arvs as compared to adults. despite the growing number of children on second-line therapy worldwide, there are limited data on efficacy of second-line pi therapy in children after nrti-nnrti failure. there are currently no options for third-line/salvage regimens for children in resource-limited settings. new drugs and drug classes are approved for use in children by the us fda but are not routinely available outside of high-income settings. also, there are no data on the resistance patterns of children failing second-line therapy in resource-limited settings to guide clinical management and arv procurement. clinicians need evidence-based guidelines for how to manage children with treatment failure, and access to the drugs necessary to construct potent and durable third-line regimens. taser-p is a longitudinal observational cohort study to monitor for treatment failure to second-line art in asian children.

Eligibility criteria:
inclusion criteria: * age \< 18 years old * have confirmed hiv infection * are being switched to or treated with second-line art. second-line art is defined as the second regimen with a major antiretroviral class switch. for example, a switch from an nnrti-based to a pi-based regimen or vice versa * caregivers give informed consent. children will be asked to give assent if they know their hiv status and have reached the minimum age to give assent according to each site's institutional review board regulations exclusion criteria: * started mono- or dual- therapy as the first art therapy * failing first-line triple nucleoside reverse transcriptase inhibitor regimen * are being switched to or treated with second-line art without failure of first-line therapy (i.e., for toxicity) * caregiver +/- child (if asked to give assent) refuses to participate in this study * have not been enrolled in taphod

Keywords: longitudinal observational cohort study multicenter pediatrics asian treatment failure renal status toxicities therapeutic drug monitoring (tdm) drug levels in blood and hair
dexmedetomidine versus fentanyl for sedation of postoperative mechanically ventilated neonates

Conditions: Postoperative Pain

Summary: newborn infants experience pain after surgical procedures,prevention and management of pain in neonates is important due to its deleterious consequences. fentanyl is a widely used analgesic which promotes rapid analgesia,however, is not free of adverse effects including chest wall rigidity, hypothermia, hypotension, respiratory depression and tolerance.dexmedetomidine is a selective α 2-adrenergic agonist can cause sedation, anxiolysis, analgesia and minimal respiratory depression.therefore, the objective of the study is to evaluate the safety and efficacy of dexmedetomidine compared to fentanyl in postoperative mechanically ventilated neonates.

a prospective, randomized trial, which was conducted upon neonates who needed postoperative mechanical ventilation in neonatal intensive care unit, mansoura university children's hospital.the patients were randomized to two groups according to the drug they received for postoperative sedation. the first group received dexmedetomidine infusion and the second group received fentanyl infusion.our primary outcome was the efficacy of postoperative sedation score, and the secondary outcomes were plasma cortisol level, time to extubation, time to reach 100ml/kg enteral feed, need for adjuvant sedative and skeletal muscle relaxant, length of the hospital stay, side effects of sedative drugs and mortality.

Eligibility criteria:
inclusion criteria: * neonates need postoperative ventilation. exclusion criteria: 1. major congenital cardiovascular anomalies. 2. chromosomal anomalies. 3. grade iv intraventricular hemorrhage. 4. tracheoesophageal fistula with wide gap (distance between proximal and distal end more than two centimeters).
sirolimus-coated balloon versus drug-eluting stent in native coronary vessels

Conditions: Coronary Artery Disease; Coronary Artery Stenosis

Summary: international, multicentric, prospective, investigator-driven, open-label, randomized (1:1) clinical trial to observe and evaluate the efficacy, of magic touch sirolimus coated balloon (scb) compared to one of the gold standard treatment for native vessel disease (everolimus-eluting stent, ees).

the purpose of transform ii study is to observe and evaluate the efficacy of magic touch scb compared to the gold standard treatment for native vessel disease, namely new-generation everolimus-eluting drug eluting stent (des). given the inherent and recognized limitations of stents in native vessels with diameter \<3 mm, only patients with coronary vessels up to 3.5 mm of diameter (by visual estimation) will be enrolled in this study.

Eligibility criteria:
inclusion criteria: * age \>18 years; * all patients with a clinical indication to percutaneous coronary intervention (pci) (stable coronary artery disease or acute coronary syndromes); * native coronary artery lesion in a vessel with diameter \>2.0 mm and ≦3.5 mm at visual estimation; * maximum lesion length: 50 mm. * informed consent to participate in the study. exclusion criteria: * patients with known (and untreatable) hypersensitivity or contraindication to aspirin, heparin, clopidogrel, prasugrel, ticagrelor, sirolimus or contrast media, which cannot be adequately pre-medicated; * patients participating in another clinical study; * subject is a woman who is pregnant or nursing (pregnancy test, either urine or blood test must be performed within 7 days prior to the index procedure in woman of child-bearing potential, and must not commit to initiating a pregnancy for 12 weeks after implantation, using effective contraception); * creatinine clearance \<30 ml/min; * left ventricular ejection fraction \<30%; * life expectancy \<12 months; * st-elevation myocardial infarction in the previous 48 hours; * visible thrombus at lesion site; * culprit lesion stenosis \>99% and/or thrombolysis in myocardial infarction (timi) flow \<2; * target lesion/vessel with any of the following characteristics: * concomitant pci at the same vessel with any device (vessels are considered: left anterior descending, circumflex or right coronary artery); * pre-dilatation of the target lesion not performed or not successful (residual stenosis \>30%); * severe calcification of the target vessel, at lesion site but also proximally; * highly tortuous vessel which could impair device delivery to the lesion site following investigator's judgement; * previous stent implantation at target vessel (left anterior descending artery; circumflex artery; right coronary artery); * bifurcation lesion where side branch treatment is anticipated; * left main stem stenosis \>50%; * target lesion is in left main stem * lesion is located within asaphenous vein graft

Keywords: dcb ees optical coherence tomography (oct) sirolimus everolimus tlf
comparison of corneal measurements in normal and keratoconus eyes using anterior segment optical coherence tomography and pentacam hr topographer

Conditions: The Reliability of Corneal Topographic Measurements of Keratoconus Eyes

Summary: the purpose of current study is to provide a comprehensive comparison of the reliability of corneal topographic measurements between optovue as- oct and a combined scheimpflug imaging using wavelight oculyzer pentacam hr in normal and keratoconus eyes.


Eligibility criteria:
inclusion criteria: * topography characteristic of keratoconus (skewed asymmetric bow-tie, inferior steep spot, etc.) and at least one clinical sign e.g., slit lamp findings of munson's sign, vogt's striae, fleischer's ring, apical thinning, rizutti's sign, etc. exclusion criteria: * are advanced complications of keratoconus such as corneal scars or hydrops.
mechanism of action and efficacy of muraglitazar in type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: the purpose of this study is to learn more about how muraglitazar lowers blood sugar in people with type 2 diabetes. the safety of this treatment will also be studied.


Eligibility criteria:
inclusion criteria: * type 2 diabetes; * serum triglyceride concentration \< or = 600 mg/dl; * body mass index \< or = 37 kg/m2 exclusion criteria: * type 1 diabetes; * history of myocardial infarction (mi), coronary angioplasty, bypass graft(s), valvular disease, unstable angina pectoris, transient ischemic attack (tia), or cerebrovascular accident (cva) within 6 months; * congestive heart failure (nyha class iii and iv); * uncontrolled hypertension; * women of child bearing potential * history of renal disease, peripheral vascular disease (pvd), pulmonary disease, gastrointestinal disease, active liver disease, or endocrine disease

Keywords: type 2 diabetes
intravitreal injection of ranibizumab versus sham before vitrectomy in patients with proliferative diabetic retinopathy

Conditions: Proliferative Diabetic Retinopathy

Summary: certain percent of the eyes with proliferative diabetic retinopathymay require pars plana vitrectomy (ppv) due to vitreous haemorrhage, proliferative membrane, and tractional retinal detachment. this study will compare intravitreal injection of anti-vascular endothelial growth factor (ranibizumab) versus sham injection before vitrectomy for pdr. the main focus is to see if pre-operative injection of ranibizuman can reduce peri-operative hemorrahge related complications.

eyes responding to panretinal photocoagulation can remain stable for decades, but incomplete responses and relapses can occur in a certain percent of diabetic patients showing as proliferative diabetic retinopathy. at present vitrectomy is the main intervention for those eyes with vitreous hemorrhage, proliferative membrane, and tractional retinal detachment. and the surgical procedure might be complicated because of intraoperative bleeding. and post-operative complications might be also involved. perioperative use of intraocular anti-vegf might be associated with less hemorrhage related complications and better visula acuity. this study will compare intravitreal injection of anti-vascular endothelial growth factor (ranibizumab) versus sham injection one week before surgery. the investigators tried to make sure whether pre-operative injection of ranibizuman can reduce reduce intra-operative bleeding, reduce the frequency of using endodiathermy, decrease surgical time, improve microcurculation of retina, and elevte best-corrected visual acuity.

Eligibility criteria:
inclusion criteria: * type i or type ii diabetes * there is clear indications for vitrectomy due to proliferative membrane in the vitreoretinal interface, mild hemorrhage, or tractional retinal detachment * retinal large vessels could be detected within one pd away from the edge of optic disc by oct * microcurculation could be detected by ffa in at least one quadrant * the patient could tolerant ffa examination exclusion criteria: * a history of vitrectomy or scleral bucke in the included eye * retinal laser photocoagulation treatment within 90 days in the included eye * anti-vegf treatment with 90 days in either eye * there is cocurrent neovascular glaucoma in the included eye * any reason that might hinde the procedure of vitrectomy, ffa oct or the observation of ocular fudus * a history of cere-brovascular accident or heart stroke * renal failure * could not attend follow up regularly
cryotherapy as a coadjuvant in crotaline snakebite management with antivenom.

Conditions: Snake Bites

Summary: the study aimed to determine the effect of local cryotherapy as a coadjuvant in patients with snakebite treated with f(ab')2 therapy venom at the hospital juárez de mexico.

introduction: local cryotherapy induces vasoconstriction, which leads to a reduction in the inflammatory process. however, the efficacy of local cryotherapy as a coadjuvant in snakebite treatment with f(ab')2 antivenom is unknown. objective: determine the effect of local cryotherapy as a coadjuvant in patients with snakebite treated with f(ab')2 therapy venom. material and methods: subjects with snakebite envenomation accident grade ii, according to the christopher-rodning classification, were enrolled from the clinical toxicology service of the hospital juárez de méxico. one group of patients received f(ab')2 antivenom therapy (antivipmyn®) plus local cryotherapy, and another group received only f(ab')2 antivenom therapy.

Eligibility criteria:
inclusion criteria: * patients of both genders and any age with a snake bite of poison grade ii who were admitted to the clinical toxicology service of the hospital juárez de méxico. exclusion criteria: * patients of both genders and any age with a snake bite of poison grade i, iii or iv who were admitted to the clinical toxicology service of the hospital juárez de méxico.
the ebc recovery study

Conditions: Traumatic Brain Injury; Intracerebral Haemorrhage; Subarachnoid Haemorrhagic Stroke

Summary: the purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (eeg) (bedside test) have better outcomes and wake up in the future.


Eligibility criteria:
inclusion criteria: for abi participants * abi adult (18 years and older) patients who are admitted to the intensive care unit * unconscious with glasgow coma scale (gcs) \&lt;8 on presentation and unable to follow bedside commands. * a negative covid-19 test on arrival for healthy volunteers: * 18 years and older exclusion criteria: for all participants: * \&lt;18 years of age * pregnant woman * patients with cardiac arrest on presentation

Keywords: consciousness coma recovery electroencephalogram
eye movement desensitization and reprocessing as a treatment for substance use disorders

Conditions: Substance Use Disorders

Summary: substance use disorders (sud) are often comorbid with psychological trauma, however, the complex interaction between the two is not yet fully understood. most addiction-specialized professionals do not engage in exploring past traumatic experiences of the patients due to personal, professional, and educational barriers. therefore, psychological trauma remains highly undetected and its contribution to the development and maintenance of sud is neglected. this compromises the therapeutic results of most interventions, with relapse rates in sud still remaining impressively high. emdr is one of the most effective interventions for post-traumatic stress disorder (ptsd), and has been applied to other disorders that are often comorbid with trauma, such as psychosis and depression, with promising results. nevertheless, its application in sud is still limited. taken altogether, there is a need to clarify the efficacy of eye movement desensitization and reprocessing (emdr) therapy in sud, as well as the mechanisms of action that mediate its potential therapeutic effects. the aim of this study is to 1) determine the efficacy of emdr therapy in patients with sud comorbid with psychological trauma, as well as whether changes in these clinical variables correspond to changes in salivary cortisol levels- a robust marker of the hypothalamic-pituitary-adrenal (hpa) axis; 2) investigate the mechanisms of action of emdr therapy, paying special attention to the key role that the cerebellum might play in mediating its therapeutic effects.


Eligibility criteria:
inclusion criteria: * a primary dsm-5 diagnosis of moderate to severe sud, assessed by a clinical interview. * no active drug consumption. * having experienced one or more traumatic events, assessed by the life event checklist dsm-5 (lec-5) and the childhood trauma questionnaire (ctq). * current posttraumatic symptoms, evaluated with the impact event scale-revised (ies-r). * aged from 18 to 65 years old. * sign an informed consent to participate in the study. * capable of speaking and comprehending catalan or spanish. exclusion criteria: * having received a trauma-focused therapy within the last 5 years. * severe dissociative symptoms according to the dissociative experience scale (des). * presence of acute suicidal ideation. * acute episode of a comorbid psychiatric disorder. * severe cognitive impairments. * medical illness that compromises the hpa-axis. * long-term exposure to corticoids. * claustrophobia. * subjects with pacemakers. * presence of metallic objects within the body. * pregnancy
incidence of mortality and complications after lung surgery, open thoracic aortic repair, tevar, evar.

Conditions: Morality; Lung Cancer; Aortic Aneurysm; Aortic Dissection

Summary: lung surgery, open aortic surgery, tevar, and evar are major operations that carry a higher incidence of perioperative mortality and complications compare to other surgery. the study of the incidence of mortality and complications will help the hospital to benchmark with the others. also the study of the risk factors of mortality and major complications will help to improve the patients' outcomes.


Eligibility criteria:
inclusion criteria: patients underwent * thoracic surgery * open thoracic aortic surgery * tevar * evar exclusion criteria: * emergency lung surgery * conversion from tevar to open thoracic surgery * conversion from evar to open aortic surgery

Keywords: mortality major complications lung surgery open aortic surgery thoracic endovascular aortic repair endovascular aneurysm repair