Kornimate/medical-research-clean huggingface dataset:
low dose whole lung radiotherapy for older patients with covid-19 pneumonitis

Conditions: COVID-19 Pneumonitis

Summary: low dose whole lung radiotherapy may improve survival of older patients with covid-19 pneumonitis

background: coronavirus disease 19 (covid-19) carry a high mortality rate among older patients and minorities such as ethnic africans and latinos. the chronic baseline systemic inflammation of older patients and minorities may make them more vulnerable to the cytokines storm generated by the viral infection in addition to preexisting co-morbidity. even though multiple organs failure result from the cytokine storm, pneumonia and respiratory failure often lead to death. low dose whole lung radiotherapy (ldwlrt) may modulate the inflammatory response and may decrease the need for artificial ventilation, thus improving mortality rate. methods: a phase i-ii prospective trials enrolling 500 patients, 65 years old or older from 26 countries will be conducted to investigate the impact of ldwlrt on mortality rate of covid-19 patients. the patients who will be selected would have developed pneumonias but did not require artificial ventilation. these patients will be followed for a year after receiving this treatment. their physical activities will be monitored through the ordinal scale and will be correlated with their cytokines status and oxygen saturation rate to assess the impact of the residual inflammation on their daily life. mortality rates between different ethnic group will be compared and correlated with their cytokines response to the virus and number of co-morbidities. discussion and importance of the study: we postulate that ldwlrt may improve survival rates of all patients by preventing the need for artificial ventilation which is associated with a high mortality. the inflammatory response between different ethnic groups before and following radiotherapy will be valuable to serve as baseline for future prospective pandemic studies as it has not been reported before.

Eligibility criteria:
inclusion criteria: * 65 years-old or older patients with proven covid-19 pneumonitis who may or may not require oxygen exclusion criteria: * patients with pneumonia who do not have a diagnosis of covid-19 infection, patients with covid-19 pneumonitis who require artificial ventilation or hemodynamically unstable to undergo radiotherapy or consent cannot be obtained either through the patient or power of attorney or patients already enrolled in another clinical trial

Keywords: covid-19 pneumonitis whole lung radiotherapy low dose
uk study assessing flexible dose fesoterodine in adults

Conditions: Urinary Bladder, Overactive

Summary: to explore the effects of fesoterodine when used in a flexible dose manner


Eligibility criteria:
inclusion criteria: * male or female \>18 years old * oab for \>3 months exclusion criteria: * patients with conditions that would contraindicate for fesoterodine use * patients with significant hepatic and renal disease or other significant unstable diseases. * oab symptoms caused by neurological conditions, known pathologies of urinary tract, etc.

Keywords: fesoterodine open label flexible dose oab
postural responses to external perturbation in post-stroke

Conditions: Stroke

Summary: to maintain stable body balance in daily activities, the ability to respond to external perturbations is an essential factor. such capacity is limited in pathological conditions, such as in stroke, in which postural control is impaired due to lesions to the central nervous system. impairment to postural control increases body sway during upright posture and leads to augmented frequency of falls. in this sense, the identification of mechanisms involved in body balance disorders after stroke is particularly important in situations of postural perturbation. the purpose of this project is to evaluate reactive postural responses to unpredictable external perturbations, analyzing postural dysfunctions caused by lesion to different brain areas as a result of stroke, and test principles of dynamic body balance rehabilitation.


Eligibility criteria:
inclusion criteria: * inclusion criteria are as follows. healthy participants: absence of detectable neurological or physical malfunction which might affect postural control, no use of drugs affecting body balance and preserved mental capacity. stroke patients: capacity to sustain independently orthostatic posture for at least 5 min. and preserved mental capacity. exclusion criteria: * exclusion criteria are: no orthopedic malfunction, no clinical instability associated with systemic disease, no use of drugs affecting body balance and presence of "pusher syndrome".

Keywords: cerebrovascular accident rehabilitation sensory system
aging mammary stem cells and breast cancer prevention

Conditions: Cancer of Breast

Summary: to examine whether rapamycin can reduce malignant markers and aberrant mammary stem/progenitor cells (mascs) number in surgical specimens

a non-randomized, open-label, phase ii, window of opportunity trial will be carried out to see if a 5-7 day rapamycin treatment can reduce malignant markers and aberrant masc number

Eligibility criteria:
inclusion criteria: * women with confirmed menopausal status. all patients who have not had a prior bilateral oophorectomy and/or are younger than age 60, will require menopausal status verified by fsh and estradiol local labs. * women diagnosed with dcis/lcis, atypical lobular hyperplasia (alh) or adh lesions detected by pathology * women scheduled for mastectomy or lumpectomy after dcis/lcis, alh or adh diagnosis * women consented to the ut health cancer center md anderson cancer center tissue biorepository (hsc20070684h) * women of child-bearing potential willing to practice 2 forms of contraception, one of which must be a barrier method until at least 30 days after the last dose of rapamycin. * women of child-bearing potential must have a negative serum pregnancy test at time of enrollment. * patients must be able to swallow and retain oral medication. * all patients must have given signed informed consent prior to registration on study. * patients must have normal organ and marrow function as defined below: 1. leukocytes ≥ 3,000/ul 2. absolute neutrophil count ≥ 1,500/ul 3. platelets ≥ 100,000/ul 4. ast ≤ 2.5 x uln 5. alt ≤ 2.5 x uln 6. total bili ≤ 1.5 x uln or direct bili ≤ 1 x uln exclusion criteria: * women who are pregnant. * women who are receiving any other concomitant treatment for their dcis/lcis, alh or adh * women who are taking rapamycin for another diagnosis. * women with an allergy to rapamycin or its derivatives. * active infection requiring systemic therapy. * patients who are taking any pills containing herbal (alternative) medicines are not eligible for participation. patients must be off any such medications by the time of registration. * immunocompromised subjects, including patients with human immunodeficiency virus * women currently taking strong cyp3a4 inducers or inhibitors. drugs that cannot be coadministered with rapamycin include but are not limited to: calcium channel blockers: nicardipine, antifungal agents: clotrimazole, fluconazole, antibiotics: troleandomycin, gastrointestinal prokinetic agents: cisapride, metoclopramide, other drugs: bromocriptine, cimetidine, danazol, hiv-protease inhibitors (e.g., ritonavir, indinavir), anticonvulsants: carbamazepine, phenobarbital, phenytoin, antibiotics: rifapentine. the research team can provide a full list of these medications. * patients with any of the following conditions or complications are not eligible for participation: 1. gi tract disease resulting in an inability to take oral medication 2. malabsorption syndrome 3. require iv alimentation 4. history of prior surgical procedures affecting absorption 5. uncontrolled inflammatory gi disease (e.g., crohn's, ulcerative colitis)
the effect of diabetes mellitus in colonoscopy under sedoanalgesia

Conditions: Diabetes Mellitus, Type 2; Sedoanalgesia

Summary: introduction and aim diabetes mellitus (dm) is a common endocrine disease in the world. colon polyps and colorectal cancers are reported more in dm patients. therefore diabetic patients are recommended to have colonoscopy frequently. the aim of this study is to search the effect of dm on hemodynamics, procedure times, anesthetic consumption and complications in colonoscopy under sedoanalgesia. materials and methods following institutional review board and ethics committee approval of başkent university, this study is planned to be prospective and double-blind in 50 type ii diabetic and 50 non-diabetic asa i-ii, aged between 18-65 years female patients scheduled for elective colonoscopy under sedoanalgesia. exclusion criteria are age outside the range of 18-65 years, asa phsical status ≥ 3, inability to provide informed consent, pregnancy, previous adverse reactions to medications used in the study, history of anesthesia and sedation in the last 7 days, psychiatric or emotional disorders, addiction to the opioids or sedatives used in the study, diabetic nephrophathy, high bun and creatinine values, advanced stages of diabetic nonalcoholic liver disease and high liver function tests, diabetic sensorymotor and autonomic neuropathy. after sedoanalgesia is applied systolic and diastolic blood pressure, heart rate, spo2, respiratory rate, rss, mpads, procedure times, total anesthetic doses, stomach ache and other effects will be recorded. expectations and scientific contributions there is evidence about determining the risks that diabetic patients have during colonoscopy and applying a special patient care protocol for these patients is suggested to improve the procedure and outcomes.


Eligibility criteria:
inclusion criteria: * female patients aged between 18-65 years old * type ii diabetic and non-diabetic exclusion criteria: * age outside the range of 18-65 years * asa phsical status ≥ 3 * inability to provide informed consent * pregnancy * previous adverse reactions to medications used in the study * history of anesthesia and sedation in the last 7 days * psychiatric or emotional disorders * addiction to the opioids or sedatives used in the study * diabetic nephrophathy, high bun and creatinine values * advanced stages of diabetic nonalcoholic liver disease and high liver function tests * diabetic sensorymotor and autonomic neuropathy

Keywords: diabetes mellitus sedoanalgesia colonoscopy under sedoanalgesia
sevoflurane's effect on mitral valve annular velocity in cardiac surgery

Conditions: Valvular Heart Disease

Summary: the purpose of this study is to determine sevoflurane's dose-dependent effect on left ventricular (lv) function in cardiac surgery. the change of tissue doppler imaging (tdi) of lateral mitral valve annular velocity at three different sevoflurane concentrations would be analyzed by using intraoperative transesophageal echocardiography (tee)in cardiac surgery patients.

following data would be determined after 10 min-exposure to each dosage of sevoflurane with 1.0, 2.0 and 3.0 inspired vol% (t1, t2 and t3, respectively) during remifentanil-based anesthesia (1.0 mcg/kg/min) for cardiac surgery (n=14): 1. tdi of lateral mitral annulus at systole (s'), early filling (e') and atrial contraction (a') 2. transmitral flow doppler at early filling (e), atrial contraction (a), deceleration time; 3. lv-ejection fraction (ef) 4. bispectral index (bis) 5. phenylephrine-infusion rate 6. other pressure derived hemodynamic parameters:heart rate; systolic, diastolic, and mean blood pressures; systolic, diastolic, and mean pulmonary artery pressures; central venous pressure (cvp), pulmonary capillary wedge pressure (pcwp), mixed venous o2 saturation (svo2), cardiac index (ci) and stroke volume index (svi)

Eligibility criteria:
inclusion criteria: * patients undergoing cardiac surgery exclusion criteria: * low ejection fraction \< 50% in preoperative transthoracic echocardiography * atrial fibrillation * pacemaker * pericardial and infiltrative myocardial disease * mitral annular calcification, surgical rings, prosthetic mitral valves * lateral left ventricular regional wall motion abnormality * esophageal spasm,stricture, laceration, perforation, and diverticulum * diaphragmatic hernia, * history of extensive radiation to the mediastinum * upper gastrointestinal bleeding

Keywords: cardiac surgery sevoflurane tissue doppler
translational study of molecular classification of relapsed/refractory diffuse large b-cell lymphoma

Conditions: Lymphoma, Large B-Cell, Diffuse; Gene Expression Profiling

Summary: the purpose of the study is to investigate the proportion of the cell-of-origin (coo) subtypes in relapsed/refractory diffuse large b-cell lymphoma (r/r dlbcl) treated with btk inhibitor or lenalidomide and its biosimilars.

this is a multi-center, observational, retrospective study that examines approximately 200 r/r dlbcl patients treated with btk inhibitors or lenalidomide and its biosimilars. for patients meet the inclusion criteria, gene expression analysis is performed on formalin fixed paraffin-embedded tissue by using canhelp-coo assay, and determine the coo subtype for each specimen. the proportion of coo subtypes in r/r dlbcl and the correlation between coo subtypes and clinicopathological information are further analyzed.

Eligibility criteria:
inclusion criteria: 1. histologically-confirmed diagnosis of dlbcl, including transformed large b-cell lymphoma from previous indolent lymphoma. 2. meet the definition of relapsed/refractory dlbcl. 3. patients received btk inhibitors and/or lenalidomide and its biosimilars after the failure of the first-line standard treatment. the efficacy was evaluated by the investigators. cohort plans to enroll one hundred patients with btk inhibitors treatment (excluding the combination with lenalidomide), one hundred patients with lenalidomide treatment (excluding the combination with btk inhibitors) and any number of the cases with btk inhibitors and lenalidomide combination. a) btk inhibitors include ibrutinib, zanubrutinib and acalabrutinib 4. patients with comprehensive history information and follow-up data. 5. patient able to provide written informed consent, agreeing that the donated samples and related information can be used for all medical research. exclusion criteria: 1. the archived tumor tissue is too little to test. 2. patients with primary central nerve system large b-cell lymphoma or primary mediastinal large b-cell lymphoma. 3. r/r dlbcl patients receive btk inhibitor or lenalidomide treatment for less than one cycle.

Keywords: canhelp-coo assay
a study of preoperative radiation therapy and capecitabine in locally advanced rectal cancer

Conditions: Rectal Cancer; Neoplasm Metastasis

Summary: the purpose of this trial is to study the efficacy of preoperative radiation therapy and capecitabine in locally advanced rectal cancer.

the purpose of this trial is to study the efficacy of preoperative radiation therapy and capecitabine in locally advanced rectal cancer.

Eligibility criteria:
inclusion criteria: * biopsy - proven rectal cancer * transmural rectal wall invasion * karnofsky performance status \>70 * normal bone marrow, liver and kidney function exclusion criteria: * distant metastases * prior pelvic radiation * inflammatory bowel disease * severe ischemic heart disease * anticoagulant therapy * pregnancy

Keywords: preoperative chemotherapy radiation therapy rectal cancer transmural rectal wall invasion nodal metastasis
interest of 18f-fdg positron emission tomography in the management of fevers and inflammatory syndromes

Conditions: Inflammation

Summary: patients aged 75 and over represent a heterogeneous population with fragile subjects who have a higher risk of poor tolerance to many tests and especially who have a risk of major functional loss in the event of hospitalization. it is therefore necessary to adapt our prescriptions and not to impose on these patients an examination that is unnecessary. or on the contrary, not to do without, out of ignorance, a minimally invasive examination that could be useful to these patients. in this study, the investigators wish to evaluate the interest of the pet-scan in the therapeutic management of these elderly patients


Eligibility criteria:
inclusion criteria: * patient aged 75 years and over, * patients cared for at the hus, in hospital or in consultation, during the defined period (from 01/05/2013 to 31/12/2018) * having had an 18fdg-pet/tdm * for fever or inflammatory syndrome check-ups, regardless of the duration of the evolution and the examinations already carried out * patient who has not expressed opposition to the reuse of their data for the purposes of this research. exclusion criteria: * patient who has expressed opposition to participating in the study * known explanation for fever or inflammatory syndrome * subjects under legal protection * subject under the protection of justice * subject under guardianship or curatorship translated with www.deepl.com/translator

Keywords: inflammation inflammatory syndromes fever tomography positron emission at 18f-fdg elderly patients internal medicine pet-scan
utility and work productivity data for economic evaluation of breast cancer therapies in the netherlands and sweden

Conditions: Solid Tumours

Summary: introduction: many reimbursement authorities use economic evaluation to help guide decisions regarding the adoption of new treatments in reimbursement systems. survival and quality of life are often the main measure of benefit used in an economic evaluation - expressed as a quality adjusted life year (qaly). in addition though, some decision makers will also consider the impact of a treatment on a patient's ability to continue working (expressed in terms of productivity). the aim of the present study is to estimate quality of life weights (utilities) and productivity loss for women with metastatic breast cancer (human epidermal growth factor receptor 2 positive or her 2+). methods: separate surveys will be used to assess utilities and productivity in her2+ metastatic breast cancer (mbc). to capture utilities health state descriptions or vignettes describing progressive disease, stable disease, and seven grade 3/4 adverse events (diarrhoea, fatigue, anaemia, leukopenia, anorexia, decreases in left ventricular ejection fraction (lvef), and skin rash) will be developed. the vignettes will be developed based on a literature review and in depth interviews with women with mbc in the netherlands and sweden. clinical experts in both countries will review the health states for content validity. the health states will be translated using forward and back translation. members of the general public will rate the states (100 men and women in nl; 100 women aged 50+ in sweden) using the visual analogue scale and time trade off method to determine utility values. in a separate survey women who are currently being treated or have recently completed their treatment for mbc will be surveyed regarding the impact of disease on their ability to work using a validated work productivity measure (work productivity and activity impairment) in women in the netherlands and sweden.


Eligibility criteria:
inclusion criteria: age \> 18 exclusion criteria: n/a
patient-reported outcome measures comparing static computer-aided implant surgery and conventional implant surgery

Conditions: Dental Implantation; Postoperative Pain; Computer-assisted Surgery; Patient Outcome Assessment; Dental Anxiety; Quality of Life; Oral Health

Summary: the aim of this randomized controlled trial was to compare proms in patients receiving single tooth replacement in posterior sites by s-cais and cis.

since current patient-reported outcome measures (proms) evidence related to static computer-aided implant surgery (s-cais) compared with conventional implant surgery (cis), particularly in partial edentulous patients, were still limited. the aim of this randomized controlled trial was to compare proms in patients receiving single tooth replacement in posterior sites by s-cais and cis.

Eligibility criteria:
inclusion criteria: * healthy or well-controlled systemic disease (asa classification i,ii) * a partially edentulous ridge in the premolar-molar region with existing two-sided interproximal as well as antagonist contacts * no sign of acute oral infection * periodontally healthy (or successfully treated) * more than 2 mm of keratinized gingiva at the site of surgery * sufficient bony ridge for implant placement with or without simultaneous bone grafting exclusion criteria: * diabetes mellitus * smoking more than ten cigarettes per day * pregnancy * psychiatric disorder * history of radiation therapy at head and neck area and chemotherapy * bony pathologies, namely osseous dysplasia, odontogenic cyst, tumor * history of soft tissue grafting at the prospective implant site * inadequate bony ridge with the need of bone augmentation prior to implant placement

Keywords: clinical research dental implant static computer-aided implant surgery (s-cais) patient-reported outcome measures (proms) dental anxiety pain oral health-related quality of life (ohrqol)
concussion symptom treatment and education program (c-step) in post-concussion syndrome

Conditions: Post-Concussion Syndrome

Summary: this prospective randomized intervention study aims to determine if the concussion symptom treatment program (c-step), a cognitive behavioral therapy, improves outcomes for children with post-concussion syndrome.

this prospective randomized intervention study aims to determine if c-step improves outcomes for children with post-concussion syndrome. forty children with post-concussion syndrome referred to the nationwide children's hospital (nch) complex concussion clinic will be randomized to receive either usual care in the nch complex concussion clinic (comparison) or usual care in the nch complex concussion clinic plus four weekly sessions of c-step (treatment). c-step has been developed for patients with post-concussion syndrome. the cbt intervention involves 4 primary components: psychoeducation, activity management, sleep hygiene, and relaxation training (adapted from mcnally et al., 2018). psychoeducation involves providing patients and families with information about typical concussion symptoms and recovery, the role of non-injury/psychological factors in post-concussion syndrome, and information about the mind-body connection. activity management involves setting specific goals to achieve a return to normal daily activities such as school attendance, schoolwork completion, household activities, and participating in social/leisure activities. the sleep hygiene component involves providing individualized recommendations to promote healthy sleep habits such as eliminating naps, keeping a consistent sleep schedule, turning off electronics at bedtime, or other needed modifications. finally, relaxation training involves teaching specific evidence-based strategies for relaxation and coping with stress such as diaphragmatic breathing and progressive muscle relaxation.

Eligibility criteria:
inclusion criteria: * children age 10-17 years or adults age 18 years (total age range 10-18) at the time of the enrollment visit * diagnosed concussion occurring between 1 month and 12 months prior to the enrollment visit * endorsing at least 2 symptoms on the scat-5 symptom checklist * intent to participate in the full ccc treatment program (including exercise visits once per week) exclusion criteria: * adults unable to consent, prisoners, females currently known to be pregnant, non-english speaking patient * anticipated inability to complete surveys or other study procedures (due to cognitive or other disability) * anticipated inability to complete a brain mri (due to claustrophobia, implanted hardware or other contraindications) * pre-injury severe mental illness (defined as inpatient psychiatric hospitalization, suicide attempt, history of psychotic symptoms, or bipolar disorder)

Keywords: behavior therapy, cognitive post-concussion syndrome