Kornimate/medical-research-clean huggingface dataset:
cognitive function of alcoholic compensated liver cirrhosis

Conditions: Alcoholic Liver Disease

Summary: differences in cognitive function between patients with viral and alcoholic compensated liver cirrhosis

hepatic encephalopathy (he) is one of the important complications of liver cirrhosis (lc). he exhibits alterations in cognitive, psychomotor-intellectual, emotional, behavioral, or fine-motor functions. approximately 22-74 % of patients with non-fulminant he have mhe with a frequency proportional to the patient age and the severity of the liver disease. patients with mhe exhibit disability in most functional behaviors such as social connection, alertness, emotional behavior, sleep, work, and leisure. alcohol consumption itself has a toxic effect on the brain. it has been documented that there is a neuronal loss in the cerebral cortex, hypothalamus, hippocampus, septal region, and cerebellum of an alcoholic brain. the major causes of lc are hepatitis b/c viral infection and chronic alcohol consumption. the most widely accepted theory of he pathogenesis is that toxic substances derived from the gut affect cerebral function after liver dysfunction or portosystemic shunting. this proposed pathogenetic mechanism could apply to viral compensated lc. however, it is difficult to explain the development of mhe in patients with alcoholic lc in this manner. therefore, patients with alcoholic lc may have different cognitive dysfunction as compared to patients with viral lc.

Eligibility criteria:
inclusion criteria: * those who agreed to participate in this study and signed a written consent * those who have no evidence of neurological impairment exclusion criteria: * those who have decompensated liver cirrhosis * those who have a high meld score (≥20) * those who have ohe during admission * those who have parients' refusal

Keywords: hepatic encephalopathy liver cirrhosis cognition alcohol bmi
5-year study to track clinical application of decisiondx-melanoma gene expression profile assay results

Conditions: Cutaneous Melanoma

Summary: the integrate registry study follows patients with cutaneous melanoma who have had the decisiondx-melanoma gene expression assay performed. data will be collected through review of medical records from clinical visits with physician. the purpose is to document the clinical application of results obtained from the decisiondx- melanoma multi-gene assay and to track outcomes of patients for whom decisiondx-melanoma testing has been completed. additionally the study will assess the health economic impact of decisiondx-melanoma testing as it relates to the melanoma population.


Eligibility criteria:
inclusion criteria: * patients diagnosed with melanoma and determined, by their physician, to be appropriate for decisiondx-melanoma testing and who have successful results available to the investigator are eligible for registration * patients enrolled should be reasonably able to follow-up with the enrolling physician at regular intervals for assessment of outcome data. * 16 years and older exclusion criteria: * less than 16 years of age

Keywords: melanoma cutaneous melanoma decisiondx-melanoma
single center registry of non-stemi acute coronary syndrome patients treated with bivalirudin

Conditions: Non-STEMI Acute Coronary Syndrome

Summary: this is a registry of patients with non st segment elevation myocardial infarction (heart attack) and/or unstable acute coronary artery syndrome treated with a standardized protocol including bivalirudin. data will be collected on diagnosis, treatment and outcomes.


Eligibility criteria:
inclusion criteria: * age ≥ 18 * chest pain or symptoms believed to be an anginal equivalent and representing myocardial ischemia, lasting at least 10 minutes within the past 24 hours * having any one of the following: 1. ischemic changes on ecg: st depression \>0.5 mm or t wave inversion \>2 mm 2. positive cardiac markers 3. new onset chf presumed secondary to ischemia 4. pulmonary edema 5. known coronary artery disease with typical symptoms 6. hemodynamic instability 7. sustained ventricular tachycardia exclusion criteria: * for the purpose of the ssdi, patients will be excluded if we are unable to obtain their social security number.
ovarian cancer radiomics approach in ct led evaluation

Conditions: Ovarian Cancer

Summary: when patients have suspected or confirmed ovarian cancer standard treatment will involve surgery and chemotherapy. however, as with any treatment, it is challenging to predict treatment response in advance. before treatment, all patients have a ct scan to describe where the cancer is in order to guide the treatment. there is now a new way to analyse routine scans using advanced computing methods, which may give more information about the ovarian cancer. this is called radiomics which analyses features in scans that are not visible to the naked eye. our group at imperial college london has worked on developing radiomic models to better understand ovarian cancer. this study aims to determine whether the information gained from this new approach would help us to tailor patient treatment plans to better meet the patient's individual needs, even more than done already. furthermore, the aim is to understand how different types of ovarian cancer can correlate with the radiomic findings, which may help develop potential treatments in the future.


Eligibility criteria:
inclusion criteria: * written (signed and dated) informed consent * age 18 years or over * suspected or confirmed advanced epithelial ovarian cancer (figo stage 3b or more) * being considered for active anticancer treatment i.e. primary cytoreductive surgery followed by chemotherapy or neoadjuvant chemotherapy followed by interval cytoreductive surgery * evaluable baseline portal venous phase ct scan prior to surgical or medical treatment for ovarian cancer * disease visible on pre-treatment portal venous phase baseline ct scan (≥2cm) exclusion criteria: * known contra-indication to ct with iv contrast (e.g. contrast allergy, renal failure, inability to lie flat); * unable to give informed consent; * known pregnancy; * no visible disease \<2cm on portal venous phase baseline ct scan; * previous surgery for resection of an adnexal mass; * significant artefact on ct image for example from metal prostheses that precluded meaningful segmentation of visible disease * only fit for palliative care at initial presentation

Keywords: ovarian cancer radiomics ct prognosis epithelial ovarian cancer biomarkers
fnb in acl recon under sa

Conditions: Anterior Cruciate Ligament Rupture; Femoral Nerve Block

Summary: the investigators will compare the results of sono-guided femoral nerve block in arthroscopic surgery for anterior cruciate ligament reconstruction under spinal anesthesia.

this study is a randomized controlled trial of 100 patients, who underwent history taking, physical examinations, x-rays, and mri or ultrasonography, and were diagnosed with anterior cruciate ligament rupture from september 2023 to august 2028. the 100 patients will be assigned to group i (with femoral nerve block) or group ii (without femoral nerve block) under double-blinded randomization. the randomization will be performed by an independent nurse using a computerized random sequence generator. the operators who participated in the procedure will be blinded to the participant's information. both group will undergo spinal anesthesia for arthroscopic anterior cruciate ligament reconstruction. after anesthesia, sono-guided femoral nerve block will be performed. the injection for group1 is 20 ml ropivacaine and for groupii is 20 ml 0.9% saline. a visual analog scale (vas) for pain will be recorded 1, 3, 6, 12, 18, 24, 36, 48 hours after the operation. vas scores range from 0 to 10, with 0 being no pain and 10 being the most severe pain ever experienced. injection with ultrasonography will be performed by a single anesthesiologist. 3 orthopedic surgeons will perform the surgery.

Eligibility criteria:
inclusion criteria: * individuals who are scheduled to undergo arthroscopic anterior cruciate ligament reconstruction surgery and must be received sufficient explanation about the research prior to surgery and have provided their informed consent to participate. exclusion criteria: * who require simultaneous surgery for concomitant cartilage injury, medial meniscus tear, and lateral collateral ligament tear. * who have previously undergone surgical treatment within the knee joint. * who have declined to participate in the research. * where medical, surgical, or anesthetic complications occurred during surgery. * other cases deemed necessary by the researchers.
a randomized trial of vaccine adherence in young injection drug users

Conditions: Medication Adherence; Substance Abuse, Intravenous; Risk Behavior; Hepatitis A; Hepatitis B; Hepatitis C

Summary: the purpose of this study is to compare the effects of (a) immunization setting and (b) outreach worker support on young injection drug users' (idu) adherence to a multiple dose immunization schedule with a combined hepatitis a virus (hav) inactivated and hepatitis b virus (hbv) recombinant vaccine.

this is a research trial consisting of a cross-sectional screening study and a prospective cohort study (randomized, 2x2 factorial design). the primary aim of the study is to evaluate the effects of immunization setting and outreach worker support on young idu's adherence to a multiple dose immunization schedule with a combined hav and hbv vaccine. secondarily, the study will 1) explore the feasibility of a remote immunization network and web-based vaccine registry to improve immunization coverage of transient young idu, 2) examine the effect of hepatitis c virus (hcv) infection in vaccine effectiveness, and 3) assess behavior change and vaccine attitudes in young idu participating in a preventive vaccine trial. subjects in the screening study complete an interview, receive counseling and testing for hiv, hav, hbv and hcv, and return in one week for test results and risk reduction counseling. subjects eligible for the cohort study receive their first immunizations at enrollment and then are randomized to receive subsequent vaccines at either a set of syringe exchange programs (sep) or at a public health adult immunization clinic (aic). subjects also are randomized to receive vaccine reminders from an outreach worker or no outreach worker support. each subject receives a total of 4 immunizations over 6 months. follow up visits include interviews, counseling, and viral testing. study participation is for 12 months.

Eligibility criteria:
inclusion criteria (screening study): * age 14-29 at screening * injected drugs in the prior 30 days exclusion criteria (screening study): * prior positive hiv antibody test * prior hbv immunization inclusion criteria (vaccine cohort): * participated in the screening study * tested negative for hiv-1 antibody and hbv markers in the screening study * returned for screening test results within 30 days of testing
the effect of stress ball application on stress, anxiety and comfort during chemotherapy in women with breast cancer

Conditions: Patients With Breast Cancer

Summary: this research was conducted as a randomized controlled study to determine the effect of stress ball application on stress, anxiety and comfort in women with breast cancer receiving chemotherapy.

the research was conducted as a randomized controlled study. a total of 74 patients were randomly assigned to the stress ball group (n=37) and the control group (n=37).

Eligibility criteria:
inclusion criteria: * who is literate in turkish, * who was diagnosed with stage 1, 2 and 3 breast cancer * who had the second cure or above chemotherapy receiving treatment * over 18 years of age * female * platelet level \>50,000 mm3 * not having any physical problems squeezing a stress ball exclusion criteria: * those who did not agree to participate in the study * those who received chemotherapy for the first time, * those who had any physical disability to squeeze a stress ball * any receiving intravenous treatment from both arms, * having had a unilateral or bilateral mastectomy and having a problem squeezing a stress ball, * having any psychiatric disease,

Keywords: anxiety comfort breast cancer stress stress ball
a prospective study to examine the effectiveness and safety of antivirals in volunteers who receive short-term prophylaxis against pandemic influenza

Conditions: Pandemic Influenza

Summary: this aim of this project is to evaluate the efficacy of neuraminidase inhibitors as short-term prophylaxis against pandemic influenza infection in people who have close familial contact with the disease. the study is observational only. the primary measure used in this study will be the incidence of symptomatic pandemic influenza in patients receiving prophylaxis. seroconversion to pandemic influenza, the incidence of adverse events and the relative effectiveness of oseltamivir and zanamivir prophylaxis will also be examined. this project will commence upon pandemic influenza being declared in australia, hong kong or singapore. data will be analysed as quickly as possible to help inform the continued use of neuraminidase inhibitor therapy as a cornerstone of the public health agency response to pandemic influenza.

the aim of this study is to 1. describe the effectiveness of short-term prophylaxis against symptomatic pandemic influenza infection 2. describe the safety of short-term prophylaxis 3. describe the seroconversion rate against pandemic influenza among recipients of short-term prophylaxis the study is an open label prospective cohort study. contact group members of people with diagnosed influenza who are recommended to receive na inhibitor prophylaxis for short periods of time will be enrolled following provision of informed consent. each episode of short-term prophylaxis will be recorded separately. by design it is hoped that volunteers in this study who develop symptoms and signs of pandemic influenza infection will be enrolled in the index case (pipet a) protocol with follow-up as required.

Eligibility criteria:
inclusion criteria: * provision of written informed consent * intention to commence or have commenced short-term prophylaxis with a neuraminidase inhibitor in individuals who have been exposed to the pandemic virus exclusion criteria: * none

Keywords: prophylaxis pandemic influenza influenza a h5n1 virus
effects of single plasma exchange and double filtration plasmapheresis (dfpp) on peripheral lymphocyte phenotypes in patients with chronic inflammatory demyelinating polyradiculoneuropathy

Conditions: Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

Summary: cidp, a rare disorder affecting young adults, causes gradual weakness of the limbs, areflexia and impaired sensory function. new cidp phenotypes without antibodies but with modified cell profiles have been described. treatments include corticotherapy, ivig and plasmapheresis but the latter's action mechanisms remain unclear. plasmapheresis supposedly removes toxic agents like antibodies from plasma but it is uncertain whether it has an immune-modulating effect. also, the refining mechanisms of the two main plasmapheresis techniques - single plasma exchange and double filtration plasmapheresis (dfpp) - are different and unclear. this study aims to compare the evolution of peripheral lymphocyte profiles in patients with cidp according to their treatment (single centrifugation plasmapheresis or dfpp) to better grasp the action mechanisms of both techniques.


Eligibility criteria:
inclusion criteria: * patients with confirmed chronic inflammatory demyelinating polyneuropathy (cidp) without pathogenic antibodies and stable under therapeutic plasmapheresis with one session every 2-3 weeks for at least two months. * patients who have given free written informed consent. * patients who have signed the consent form. * patients affiliated to or beneficiaries of a health insurance scheme. * adult patients (≥18 ans). * healthy subjects of the same age and sex exclusion criteria: * patients under the age of 18. * patients under immunosuppressive treatment for less than 3 months. * patients participating in category 1 research involving human subjects. * patients in an exclusion period determined by another study. * patients under legal protection, guardianship or curatorship. * patients unable to express consent. * patients for whom it is impossible to give informed information. * pregnant, parturient or breastfeeding patients. * healthy subject with chronic pathology or drug treatment

Keywords: plasma exchange double filtration plasmapheresis
study of vanadis® nipt for non-invasive prenatal screening of trisomies (t21, t18 and t13)

Conditions: Trisomy 21; Trisomy 18; Trisomy 13

Summary: this study will assess the feasibility of vanadis nipt for screening of t21, t18 and t13. the results obtained from vanadis nipt will be compared with the study site's current prenatal screening methods. the primary objectives are: 1) to assess the feasibility of vanadis nipt for screening of t21, t18 and t13 in the maternal healthcare setting, 2) to assess preliminary performance of vanadis nipt for screening of t21 in comparison to site's routine screening methods i.e. combined and integrated tests, and 3) to evaluate preliminary cost effectiveness of vanadis nipt use in different models. the secondary objective is to assess the feasibility of vanadis nipt regarding determination of fetal sex.


Eligibility criteria:
inclusion criteria: * between the age of 18 and 55 years (inclusive) * ≥ 10+0 weeks gestation exclusion criteria: * pregnant woman undergoing amniocentesis without any screening test result * pregnant woman with previous severe hypotension episodes or other conditions that may complicate the blood sampling * known maternal aneuploidy * known maternal cancer * invasive test (chorionic villus sampling or amniocentesis) performed before blood sampling for nipt

Keywords: vanadis nipt system
the effect of bristle brush, rubber cup, and air polishing on tooth surface roughness of scaled teeth

Conditions: Periodontal Diseases; Tooth Abrasion; Dental Plaque

Summary: this study investigates the effects of three polishing methods using a bristle brush, rubber cup, and air polishing on the surface roughness of scaled human teeth. the study aims to determine which polishing method is most effective in minimizing roughness and preventing plaque accumulation, thus contributing to improved oral health practices.

tooth surface roughness influences plaque retention and periodontal health. polishing after scaling helps smoothen enamel surfaces, reducing bacterial adhesion. while various studies have assessed polishing techniques, there are inconsistencies in findings, particularly regarding air polishing vs. rubber cup polishing. additionally, most studies focus on bovine teeth or indirect restorative materials rather than extracted human teeth. using a randomized controlled trial (rct) design, 56 extracted teeth will be divided into four groups: a control group (no polishing) and three experimental groups subjected to different polishing techniques. surface roughness will be analyzed using a scanning electron microscope (sem). this study aims to fill these research gaps and provide region-specific data by determining which polishing method is most effective in minimizing roughness and preventing plaque accumulation, thus contributing to improved oral health practices.

Eligibility criteria:
inclusion criteria: * extracted human teeth with intact buccal or lingual surfaces. * patients with a history of trauma affecting the oral cavity will be eligible, provided they meet other criteria (e.g., intact buccal or lingual surfaces). * male and female patients aged 18 years and above. exclusion criteria: * teeth with restorations, caries, fractures, or significant developmental defects (e.g., amelogenesis imperfecta, dentinogenesis imperfecta , fluorosis etc). * patients with systemic disease such as diabetes mellitus, cardiovascular disorders or any other condition will be excluded. * mentally impaired patient. * patients who have undergone scaling and polishing within the last 3 months.

Keywords: tooth roughness dental polishing bristal brush periodontology
a study to assess safety of current standard malaria treatment and an assessment of g6pd status in south-east bangladesh

Conditions: Malaria

Summary: this is a study assessing safety and efficacy of current national guidelines for the treatment of uncomplicated malaria in bangladesh as well as to assess the g6pd status among the enrolled patients.

the national guidelines for the treatment of uncomplicated malaria in bangladesh currently recommend a standard dose of artemether-lumefantrine followed by a single dose of primaquine for p. falciparum malaria and a three day course of chloroquine followed by 14 days of primaquine for vivax malaria.currently the national treatment guidelines do not include any testing for g6pd deficiency before treatment with primaquine. in order to guarantee safe and efficacious treatment for all patients diagnosed with uncomplicated malaria in bangladesh, it is essential to monitor the effectiveness and safety of the recommended treatment guidelines. this trial therefore evaluates the local efficacy and safety of the current first line treatment and assesses the g6pd status of the enrolled patients. patients with uncomplicated malaria attending the health care center, who meet the study inclusion criteria will be enrolled, treated on site and followed up for 28 days. the follow-up will consist of a fixed schedule of check-up visits and corresponding clinical and laboratory examinations. the study will provide efficacy data for both artemether-lumefantrine and chloroquine and will generate data on g6pd status in the region, which will provide vital information for policy makers in regards to the wider roll out of primaquine for the radical cure of vivax malaria.

Eligibility criteria:
inclusion criteria: * age ≥ 12 months * p. vivax or p. falciparum monoinfection or p.v. / p.f. mixed infection * presence of axillary temperature ≥ 37.5°c or history of fever during the past 24 hrs * ability to swallow oral medication. * ability and willingness to comply with the study protocol for the duration of the study * informed consent/assent from the patient or from a parent or guardian in the case of children. exclusion criteria: * presence of general danger signs in children aged under 5 years or signs of severe malaria according to the definitions of who * presence of severe malnutrition * acute anaemia \<8g/dl * regular medication, which may interfere with antimalarial pharmacokinetics * history of hypersensitivity reactions or contraindications to any of the drug(s) tested or used as alternative treatment(s) * a positive pregnancy test or lactating
effects of alcoholic beverages in pro-inflammatory and antioxidant profile after an oral fat diet

Conditions: Alcohol Consumption

Summary: hypothesis: red wine intake but not other alcoholic beverages together with a fat diet will decrease inflammatory factors and lipid peroxidation and decrease antioxidant capacity in healthy people after a five days period.


Eligibility criteria:
inclusion criteria: * healthy volunteers exclusion criteria: * individuals with a plasma cholesterol level \> 220 mg/dl * smokers

Keywords: alcohol, inflammation, oxidation.