Kornimate/medical-research-clean huggingface dataset:
a translational study for locoregional recurrence of t4 colon cancer

Conditions: T4 Colorectal Cancer; Colorectal Cancer Stage III; Colorectal Cancer Stage II

Summary: the outcome of t4 locally advanced colon cancer is poor when locoregional recurrence occurred. previous studies had showed that the aggravation of t4 colon cancer is higher than n-positive colon cancer, contributing to staging paradox that outcomes of stage iib/c are poorer than stage iiia colon cancer and higher locoregional recurrence of stage iib/c colon cancer. the phenomenon cannot be explained by radicality, lymph node harvested and adjuvant chemotherapy administration. to elucidate the cancerous aggravation of t4 colon cancer, the investigators should dive into the clinicopathology, metastatic mechanism and cancer biology. the investigators hypothesize that peritoneal spreading can be one of the metastatic routes of t4 colon cancer; however, few studies have addressed the finding and deserved investigation. previous research have found that serum epigenetic alterations and cell-free dna can serve as a prognostic marker for stage ii/iii colon cancer. therefore, the aim of this study is (1) to explore the role of ascites cfdna as a potential biomolecular marker for locoregional recurrence; (2) to identify the risk factors of locoregional recurrence for t4 colon cancer by correlating biomolecular markers between clinicopathology, epigenomic alterations in blood and ascites.


Eligibility criteria:
* inclusion criteria: 1. age ≥ 18 years old 2. diagnosed as colorectal cancer 3. undergo radical colectomy or palliative colectomy, not limited to minimally invasive surgery or open surgery * exclusion criteria: 1. age\<18 years old 2. pregnancy 3. patients with peritoneal dialysis 4. patients who are unwilling to undergo colorectal surgery
the role of fdg-pet/ct imaging in the management of patients with thromboembolic disorders (the petvet study)

Conditions: Venous Thromboembolic Disease

Summary: this pilot study aims at validating 18f-flourodeoxyglucose positron emission tomography/computed tomography (fdg-pet/ct) in the detection and characterization of venous thromboembolism (vte) in the entire human body, especially deep venous thrombosis (dvt) and pulmonary embolism (pe). on completion of this study the investigators will hopefully be able to demonstrate the importance of functional/molecular imaging technique in managing patients with this common and potentially fatal disorder.

acute dvt and pe are common and serious conditions. highly effective treatment (most often anticoagulant agents) is available for acute vte, but it is associated with potentially dangerous side effects. in addition, dvt and pe are just two manifestations of vte, which can occur everywhere in the human organism. an underlying disease (i.e. cancer) is often a key factor in developing vte. commonly used diagnostic imaging techniques in dvt and pe have a fair diagnostic accuracy, but do not address other important aspects of the disease. in contrast to this, fdg-pet/ct has the potential to contribute in vte diagnosis by * differentiate between acute and chronic vte * screening of the entire body for vte (e.g. the pelvis where normal imaging techniques fail) * early diagnosis of underlying disease (e.g. cancer, with the possibility of early treatment) this is a pilot study with the above mentioned objectives, and is part of a larger study addressing other aspects of fdg-pet/ct in vte. the investigators believe that their hypothesis that fdg-pet/ct imaging may introduce a new approach for detecting thrombi anywhere in the body, particularly in the venous system including the pelvis and the calves, will add a new dimension in treating patients with suspected pe. this technology will only detect acute thrombi and not chronic thrombi that no longer have activity, which will obviate unnecessary treatment in this population.

Eligibility criteria:
inclusion criteria: * positive or negative diagnosis of vte (dvt/pe) * age ≥ 50 years * informed consent obtained * symptoms \< 1 week exclusion criteria: * pregnant or lactating women * foreign language patients with a need for an interpreter * previous dvt or pe * known malignancy

Keywords: venous thromboembolic disease deep veinous thrombosis pulmonary embolism
low grade inflammation, gut microbiota and barrier function in elderly humans

Conditions: Aged; Healthy

Summary: cardiovascular diseases (cvd) are the main cause of death in the european union. a large part of the aging process, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, wich results in the low grade chronic pro-inflammatory status termed inflammaging. it can contribute to a number of age-related chronic diseases (e.g. atherosclerosis, type 2 diabetes, alzheimer disease, osteoporosis). prevention or delay in onset of chronic diseases can potentially benefit a large segment of the elderly population. now it is hypothesised that a probiotic drink can reduce low-grade inflammation through improvement of the gut barrier function and gut microbiota composition in elderly people with low-grade inflammation.

cardiovascular diseases (cvd) are the main cause of death in the european union. a large part of the aging process, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, wich results in the low grade chronic pro-inflammatory status termed inflammaging. it can contribute to a number of age-related chronic diseases (e.g. atherosclerosis, type 2 diabetes, alzheimer disease, osteoporosis). prevention or delay in onset of chronic diseases can potentially benefit a large segment of the elderly population. now it is hypothesised that a probiotic drink can reduce low-grade inflammation through improvement of the gut barrier function and gut microbiota composition in elderly people with low-grade inflammation.

Eligibility criteria:
inclusion criteria: * men \>65 years of age. * body mass index: 22-34,9 kg/m² * non-smokers intervention trial: * hscrp \> 1 mg/l (screening blood test) * normal blood count (screening blood test) * normal alat, asat and serum creatinine levels (screening blood test) exclusion criteria: * any major non-organic disease, including malign diseases (haematological, inflammatory, metabolic,) * any major organ disease, including neoplastic diseases. * intake of antibiotics within the last 6 weeks * chronic therapy with analgetics (incl. acetylsalicylic acid) * chronic therapy with proton pump inhibitors * regular intake of probiotic bacteria products within the last 3 weeks * chronic anti-inflammatory therapy with nsars or previous therapy within the last 20 days * subjects with expected non-compliance to protocol guidelines * subjects that participate in other trials

Keywords: healthy eldery people
identifying changes in blood (potential biomarkers) in individuals with drug-induced liver injury

Conditions: Drug Induced Liver Injury

Summary: the purpose of this study is to try to develop new blood tests that may help doctors identify if a drug is hurting a person's liver.

our hypothesis is that there are liver-specific particles, called mrna, that are identifiable in a person's blood sample during liver injury caused by some drugs. the purpose of this study is to try to develop new blood tests that may help doctors identify if a drug is hurting a person's liver, perhaps early in the process before significant injury or illness have occurred.

Eligibility criteria:
inclusion criteria: * alt \> 200 iu/l at presentation to unc hospitals * drug induced liver injury considered likely by admitting medical staff
a dose finding study of cc-96673 in participants with relapsed or refractory non-hodgkin's lymphoma

Conditions: Lymphoma, Non-Hodgkin

Summary: the purpose of this phase 1 study is to evaluate the safety and tolerability of cc-96673 in adult participants with relapsed or refractory non-hodgkin's lymphoma (r/r nhl). the study will be conducted in 2 parts: part a, monotherapy dose escalation and part b, monotherapy dose expansion.


Eligibility criteria:
inclusion criteria: participants must satisfy the following criteria to be enrolled in the study: 1. participant (male or female) is ≥ 18 years of age at the time of signing the informed consent form (icf). 2. participant must understand and voluntarily sign an icf prior to any study-related assessments/procedures being conducted. 3. participant is willing and able to adhere to the study visit schedule and other protocol requirements. 4. participant must have a history of nhl that has relapsed or progressed. 5. participant has an ecog ps of 0 or 1. 6. participants must have acceptable laboratory values as specified in the protocol. exclusion criteria: 1. participant has cancer with symptomatic central nervous system (cns) involvement 2. participant is on chronic systemic immunosuppressive therapy or corticosteroids or subjects with clinically significant graft-versus-host disease (gvhd). intranasal, inhaled, topical, or local corticosteroid injections, or steroids as premedication for hypersensitivity reactions are exceptions to this criterion. 3. inadequate cardiac function or significant cardiovascular disease 4. participant has received prior investigational therapy directed at cd47 or sirpα. 5. participant had major surgery ≤ 2 weeks prior to starting cc-96673. 6. participant is a pregnant or lactating female or intends to become pregnant during participation of the study. 7. participant has known active human immunodeficiency virus (hiv) infection. 8. participant has active hepatitis b or c (hbv/hcv) infection. 9. ongoing treatment with chronic, therapeutic dosing of anti-coagulants. 10. history of autoimmune hemolytic anemia or autoimmune thrombocytopenia. 11. history of concurrent second cancers requiring active, ongoing systemic treatment. 12. participant has any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study. 13. participant has active, uncontrolled, or suspected infection. other protocol defined inclusion/exclusion criteria could apply.

Keywords: relapsed or refractory non-hodgkin's lymphoma cc-96673 dose finding
catheter dysfunction rate in patients undergoing kidney replacement therapy. evaluation of the safety and efficacy of anti-reflux valves without heparin lock solution

Conditions: Chronic Renal Failure; Haemodialysis, Haemodiafiltration, Haemofiltration; Kidney Replacement Therapy; Catheter Infection, Catheter Dysfunction, Catheter Related Bloodstream Infections

Summary: catheter dysfunction and infections are the most common complications observed among patients with dialysis catheters for long-term dialysis ( cdld ) . they are causing a worsening of the morbidity and mortality of patients , loss of quality of renal replacement therapy , a reduction in the duration of catheterization , as well as increased spending related to health care. the use of anti- reflux ( tego ® , icu medical , usa, distributed by the laboratory hemotech , france ) valves reduces the rate of dysfunction and infections cdld( catheters for long-term dialysis ). unpublished preliminary data suggest that these valves allow parallel use of interdialytic saline locks without increasing the risk of dysfunction. this strategy would therefore achieve significant savings usual interdialytic cdld( catheters for long-term dialysis )locks ( including heparin) whose use is not devoid of potentially serious adverse events and whose health care costs have increased dramatically in recent years . moreover, this would also produce savings in fibrinolytic treatment. a randomized controlled trial is needed to assess the effectiveness of tego ® valves in combination with saline locks on the risk of dysfunction cdld(catheters for long-term dialysis ) .

interventional prospective, multicenter (8 dialysis units) , randomized, controlled, open study. two strategies are compared in a parallel plan : a "valve arm " (implementation of tego ® valve associated with interdialytic saline locks) and a "control arm" ( standard care ). rate of dialysis session with dysfunctions during the first six months of the study is the primary endpoint. it will be analyzed " per protocol ". the total duration of patient follow-up is 12 months. after the first 6 months, patients in the "valve arm" retain the same type of care until the end of the study. the control patients continue to receive the usual concentrated heparin locks . the secondary endpoints of the study will be analyzed to 12 months. training of health care teams is expected before the start of the study .

Eligibility criteria:
inclusion criteria: * haemodialysis patients exclusion criteria: -

Keywords: catheter infection, catheter dysfunction, catheter related bloodstream infections,
a comparison of a pulse diet and the tlc diet on reproductive, metabolic parameters in women with pcos

Conditions: Polycystic Ovary Syndrome; Metabolic Syndrome

Summary: the main objective of the study is to evaluate the effectiveness of a lifestyle program for women with polycystic ovary syndrome (pcos). the investigators want to assess the efficacy of a pulse-based diet (i.e. a diet that contains lentils, chick-peas, and beans) on the clinical features, biochemical, and hormonal parameters of pcos compared to the healthy therapeutic lifestyle changes diet.

the main objective of the study is to identify the effect of pulses on a range of pcos and metabolic syndrome features. in this parallel clinical trial, 110 (18-35 years old) women with pcos will be recruited. participants will be randomly assigned to either a pulse-based diet or a therapeutic lifestyle changes-based diet. the effect of a pulse-based diet on a range of reproductive and metabolic parameters will be evaluated. the results of this study are anticipated to evaluate the therapeutic merits of a pulse-based diet for women with pcos which would influence dietary guidelines.

Eligibility criteria:
inclusion criteria: * female * diagnosis of pcos in addition to insulin resistance (homeostasis model assessment (homa)-insulin resistance index ≥ 2). * aged 18-35 years exclusion criteria: * individuals that are keto diet, vegetarian, pregnant, lactating, class 2 obese (body mass index (bmi) ≥35) current smoker, or if they have diabetes, cardiovascular, kidney, liver, or hormonal disease. * individuals taking any medication or supplementation known to affect lipid, glucose, or hormone levels, and/or body weight for at least the last 3 months. * any individual who has an allergy or intolerance to pulses.

Keywords: polycystic ovary syndrome metabolic syndrome therapeutic lifestyle changes diet pulse-based diet aerobic exercise
national survey on hypertension at hospital

Conditions: Hypertension

Summary: to evaluate (with sufficient accuracy) the profile(demographic and clinical characteristics, health care management) of hypertensive patients seen in hospital out patient's department by a cardiologist or a nephrologists.


Eligibility criteria:
inclusion criteria: * known hypertension * agree to take part in this study exclusion criteria: * none
postural control instability in children with mild autism

Conditions: Autism Spectrum Disorder

Summary: objective: individuals diagnosed with autism spectrum disorder (asd) exhibit some type of motor control impairment, for instance, motor apraxia and history of gross motor delay that could lead to increased risk of fall. this pilot research was designed to assess and characterize static postural stability and create a starting point to better understand and describe postural control in children with mild autism. method: we measured static postural control with center of pressure (cop) displacement in 10 children with mild autism during eight sensory conditions that challenge and cancel the visual, proprioceptive and vestibular systems.

materials and methods institutional review board (irb) approval at the university of puerto rico, medical science campus has obtained prior the recruitment of the participants. parents of children diagnosed with mild asd who were interested in the study called the number on the recruitment flyer. the pi spoke with the parent to assess whether their child qualified for the study based on the following inclusion and exclusion criteria. balance assessment protocol the balance assessment procedure included the following; each subject was instructed to stand on both feet for 15 seconds on the pressure matscan under eight different conditions. the first four conditions were executed over a stable surface and consisted of the following: (1) eyes open (eo) -evaluates visual, vestibular and proprioceptive systems, (2) eyes closed (ec) -eliminates visual input, evaluates vestibular and proprioceptive system, (3) eyes open while moving head up and down (at 60 beats per minute) (eo hud) -evaluates visual and proprioceptive system and alters vestibular input, (4) eyes closed while moving the head up and down (ec hud) -evaluates the effect of removing visual information, and the vestibular input being altered. the subjects then performed the same four tasks, this time standing on an unstable platform (high quality closed cell foam 19 inches long x 15 inches width x 2.25 inches)with the purpose of altering the proprioceptive input and increasing dependence on the visual and vestibular systems.

Eligibility criteria:
inclusion criteria: * children from 7-12 years of age, male or female * mild asd diagnosis (as determined by a medical doctor) * capable of ambulating independently. exclusion criteria: * children with additional neurological problems * children with visual problems * children unable to tolerate walking or standing barefoot * children who have fallen three or more times in the last three months * children with vestibular problems.
evaluation of a comprehensive school nutrition enrichment intervention (csnei) in rural school districts

Conditions: Obesity, Childhood; Nutrition, Healthy

Summary: obesity is a significant cause of cancer and cardiovascular disease incidence and mortality, and diabetes incidence among rural communities. arkansas has the sixth-highest proportion of rural population (\~41%),and has the third-highest obesity prevalence (37.4%) in the nation. arkansas has the third-highest prevalence of obesity for high school students (22.1%) and the fifth-highest prevalence for children ages 10-17 (20.2%). in arkansas, children in rural areas have very high rates of both food insecurity (26%) and free and reduced lunch eligibility (72.9%). in the study's 6 participating school districts, free and reduced lunch eligibility ranges from 51.4% to 79.3%. school meals are an important opportunity to influence students' nutritional intake and long-term food preferences, which can reduce obesity. a multidisciplinary team has partnered with 6 rural arkansas school districts which have agreed to participate in a study to evaluate the effects of an evidence-based population-level policy intervention designed to improve the nutritional quality of food served in schools. the study team will conduct a matched-pairs cluster-randomized trial with pre-test and repeated post-tests in 6 rural arkansas school districts, 3 implementing csnei, and 3 matched comparison school districts following their existing nutritional practices. baseline data collection will take place prior to implementation (year 1), and follow-up data will be collected annually thereafter (years 2-5). the study will compare individual-level change in relative body mass index (adjusted for age and sex) and district-level changes in the nutritional quality of food served, amount of food consumed per diner, and fruit and vegetable intake in school districts implementing the intervention compared to matched comparison districts.


Eligibility criteria:
inclusion criteria: - student currently enrolled at one of the 6 rural public school districts exclusion criteria: - n/a
the effect of pre-exercise feeding on bone turnover biomarkers

Conditions: Osteopenia or Osteoporosis

Summary: osteoporosis is a major contributor to loss of independence due to bone fractures and resulting hospital treatments lead to significant morbidity. while pharmacological treatments can reduce consequences of osteoporosis, there is a pressing need for non-pharmacological interventions to improve bone health across the life-course and to reduce likelihood of age-related bone disease. this study will allow us to determine whether synergistic potentiating effects on bone metabolism are observed in humans in relation to the timing of food ingestion and what recommendations can be made to people with respect to food ingestion and exercise to obtain the maximal bone benefits from aerobic exercise. furthermore, if we can identify interventions that potentiate bone's response to aerobic exercise in younger adults, then such interventions may have the ability to maximise bone mass in younger adults so that with ageing, the additional bone mineral density and improved bone microarchitecture would extend the time before osteoporotic "fracture thresholds" are reached. therefore, understanding the bone metabolic response to exercise following fasting and feeding in younger adults is important.


Eligibility criteria:
inclusion criteria: * male (females excluded to remove the interplay between menstrual cycle and bone turnover) * caucasian ethnicity * aged 28 ± 4 years * are physically active (meet the uk guidelines for physical activity of at least 150 minutes moderate intensity activity and/or at least 75 minutes of vigorous intensity activity per week) * otherwise, healthy, able and willing to participate and provide written informed consent exclusion criteria: * current smokers * excessive alcohol consumption (max 15 alcohol units/week) * any musculoskeletal injury/disabilities * any conditions known to affect bone metabolism (e.g. uncontrolled hyper-/hypothyroidism, hyperparathyroidism, hypo-/hypercalcaemia) or malabsorption syndromes (e.g. crohn's disease, coeliac disease or inflammatory bowel disease). * taking any medication known to affect bone metabolism (such as glucocorticoids or bisphosphonates) * positive covid-19 test within the last 8 weeks * suffered a fracture in the previous 12 months * sedentary status (see physical activity inclusion criteria above) * have been told by medical professionals that they should not take part in moderate to high intensity exercise * should not be a professional athlete or take part in significant competitive recreational activity (takes no more than 4 structured exercise sessions per week on average) * history of diagnosed eating disorders