Kornimate/medical-research-clean huggingface dataset:
study of pulmonary infections (pneumonia) in kidney transplant recipients admitted to hospital

Conditions: Kidney Transplant Infection

Summary: the investigators aimed to identify prognosis factors associated with in-hospital complications and assess the epidemiology, management, and outcomes of community-acquired pneumonia in a kidney transplant recipients' cohort. the investigators intend to identify each stay by a national database. then they will be consulted by 2 clinicians to assert cap clinical definition. after that radiographic evidence will be reviewed to validate cap diagnoses. then clinical data are collected in each center.


Eligibility criteria:
inclusion criteria: * kidney transplant recipients * at least 18 years * admitted to hospital for cap. non-inclusion criteria were: exclusion criteria: * incomplete cap definition * hospital-acquired pneumonia * another diagnosis explaining the symptoms * patients with non-functional kidney graft
prediction of pelvic adhesions at repeat cesarean delivery

Conditions: Decrease Maternal Morbidity

Summary: several methods have been used to predict adhesions after abdominal operations. high-resolution ultrasonography, magnetic resonance imaging and scar healing properties were the methods that were evaluated in the english literature for this study. estimating the likelihood of adhesions and related complications after prior surgery and assessing the severity of adhesion formation after surgery is not easy. anticipating adhesions is very important to preventing complications by ensuring that the necessary preoperative preparations are in place and/or that appropriate cases are referred to a tertiary center.


Eligibility criteria:
inclusion criteria: 1. women with at least previous one cesarean 2. full term (37- 41 weeks) 3. women accepted to participate in the study exclusion criteria: 1. history of pelvic inflammatory disease 2. history of endometriosis 3. previous pelvic surgery other than cesarean 4. history of wound site infections 5. history of long corticosteroid use 6. women with midline incisions 7. women with placenta accreta 8. women refuse to participate in the study
the effects of hand-arm bimanual intensive training (habit) in children with bilateral cerebral palsy

Conditions: Cerebral Palsy

Summary: hand-arm bimanual intensive training (habit) has been shown to result in improvements in hand function and daily functioning of children with unilateral cerebral palsy (cp). children with bilateral cp may also present difficulties to coordinate their hands to perform activities. thus, habit may be a potential intervention for these individuals. we intend to examine the effects of habit on hand function and daily functioning of children with bilateral cp compared with conventional occupational therapy (ot). our hypothesis is that children receiving habit will present larger improvements in manual dexterity and daily functioning as compared to conventional ot.

study design: randomized controlled trial. study participants \& setting: forty children with bilateral cp recruited from the associação mineira de reabilitação, belo horizonte, brazil. procedures: after being included in the study, children will be randomly assigned to a intervention group (n=20) or a control group (n=20). children in the intervention group will receive a 90-hour (6 hours/day; 5 days/week, 3 weeks) of hand-arm bimanual intensive training (habit) while children in control group will maintain their usual frequency of occupational therapy (ot) sessions (45 minutes/session, twice a week, for 3 weeks), focusing on functional training, stretching and sensory stimulation. all participants will be assessed by an examiner blinded to group allocation before and after the intervention period, as well as 6 months after the intervention (follow-up). statistical analysis: a 2 (groups) x 3 (assessments) analysis of variance will test the effects of group, assessment and group x assessment interaction with a level of significance set at 0.05.

Eligibility criteria:
inclusion criteria: * medical diagnosis of bilateral cp; * age between 4 and 17 years old; * manual ability classification system (macs) ranging from levels i to iii; * ability to understand verbal instructions. exclusion criteria: * botulinum toxin or surgery in upper limbs in the previous 6 months of the study.

Keywords: cerebral palsy rehabilitation hand function daily functioning hand-arm bimanual intensive training
do anesthesiologists follow guidelines on perioperative use of tranexamic acid?

Conditions: Tranexamic Acid; Blood Loss, Surgical; Blood Transfusion

Summary: tranexamic acid has been used to reduce bleeding and transfusion for years. randomized studies showed its efficacity in orthopedic surgery, trauma and post-partum hemorrhage. few data were available for other types of surgery and the safety profile of tranexamic use was nor clearly established. in april 2022, the results from the poise-3 (perioperative ischemic evaluation - 3) trial was published in the new england journal of medicine. this stdy clearly demonstrated in 9535 patients undergoing non-cardiac surgery, that the use of tranexamic acid significantly reduced not only perioperative bleeding, but also transfusions. the safety profile of tranexamic acid was very good in this trial. this publication was rapidly followed by editorials in major anesthesia journals, calling for "safe surgery" with a systematic use of tranexamic acid in the population studied in the poise-3 trial. a literature review was done with a formal presentation at erasme university hospital, again with the call for a systematic use in appropriate patients. in this study, the adherence to these recommendations will be tested. all patients operated between october 1st 2022 and december 31 st 2022 will be included. for every patient, it will be determined if this patient should have received tranexamic acid according to the results of the poise-3 trial and wether this patient really did get tranexamic acid. primary endpoint will be the percentage (%) of patients correctly treated according to the poise-3 recommendations. a second primary endpoint will be the comparison with patients operated between october 1st 2021 and december 31st 2021; that means before the publication of the recommendations. the difference between both populations will be tested with a chi-square test. secondary outcomes wil be bleeding and transfusion in the correctly treated population compared with an eventually not correctly treated population.


Eligibility criteria:
inclusion criteria: * patients undergoing surgery either between oct 1st 2021 and dec 31st 201 or oct 1st 2022 and dec 31st 2022 * noncardiac surgery * expected to require at least one overnight hospital admission after surgery * at risk of perioperative bleeding exclusion criteria: * cardiac surgery * intracranial neurosurgery * creatinine clearance \< 30 ml/min (cockcroft-gault equation) * chronic dialysis * history of seizure disorder * recent (\< 3 months) stroke, myocardial infarction, acute arterial thrombosis, venous thromboembolism * fibrinolytic condition following consumption coagulopathy * subarachnoid hemorrhage within 30 days before surgery * women of childbearing potential who are not taking effective contraception, pregnant or breast-feeding
simultaneous multiple cruciate ligament reconstructions using a single achilles allograft

Conditions: Rupture of Posterior Cruciate Ligament; Rupture of Anterior Cruciate Ligament

Summary: this study introduce cases of simultaneous multiple cruciate ligament reconstructions with a single free tendon achilles allograft using new technique.


Eligibility criteria:
inclusion criteria: * subjects who had any concomitant meniscus or cartilage injuries exclusion criteria: * subjects who required reconstruction of medial or lateral collateral ligament, or posterolateral ligament complex * subject who wanted reconstruction with autograft * subject who denied participation in this study * subject who would meet the national reimbursement criteria

Keywords: achilles allograft cruciate ligament reconstruction
dexmedetomidine and magnesium sulfate in preventing junctional ectopic tachycardia after pediatric cardiac surgery

Conditions: Post Operative Arrythmia

Summary: to study the prophylactic effect of magnesium sulfate , dexmedetomidine or their combination in reduction the incidence of jets postoperative

following approval from research and ethics committee, preoperative preparation, and anesthesia inductuion. the baseline heart rate (hr) and blood pressure (bp) will be recorded. the patients will be divided into three groups according to the type of drug injected. group md (dexmedetomidine mgso4 group): include (40 ) patients and will receive dexmedetomidine 0.5 µg/kg diluted in 50 ml of normal saline intravenously over 20 minutes, after induction followed by 0.5 µg/kg per hour infusion for 72 hours postoperatively or ready for extubation prior to 72 hour time period (precedex ; hospira worldwide ,lake forest, il).(20) and receiving magnesium sulfate (50 mg/kg) bolus administered at the time of aortic cross clamp release. with continued administration for 72 hours postoperatively at a dose of 30 mg/kg/day.(21) group d (dexmedetomidine group): include (40 ) patients and will receive the same of dexmedetomidine as md group in addition to normal saline instead of magnesium sulfate . group c (control group): include (40 ) patients and will receive normal saline instead of dexmedetomidine and mgso4 . after the end of the procedure, inhalational anesthetics will be stopped as well the muscle relaxant. the patient will be transferred to the icu. in icu , the post-operative rhythm was monitored to detect the early incidence of arrythmia diagnostic criteria for jet included the following: * tachycardia with qrs similar to sinus rhythm qrs * a ventricular rate more than 170 beats/min * av dissociation with or without hemodynamic compromise * a ventricular rate faster than the atrial rate. (8) early onset postoperative jet was defined as the presence of jet during the first 72 h postoperatively. continuous ecg monitoring will be used continuously in the pccu. standard 12-lead ecg will be registered in all patients preoperatively and at the time of pccu admission. when jet was detected on the ecg monitor this will be also documented with a standard ecg strip patients who developed jet and were hemodynamically unstable were managed with mild hypothermia, reduction in inotropes, magnesium, digoxin, and amiodarone.

Eligibility criteria:
inclusion criteria: * age: less than 5 yrs. * weight: more than 5 kg . * pathology :a-v canal ,vsd ,asd undergoing corrective surgery with normal sinus rhythm, and stable hemodynamics. exclusion criteria: * a history of arrhythmias within the last 6 months, current use of antiarrhythmic medication such as amiodarone, digoxin. * patients with pacemaker or atrioventricular (a-v) block. * known allergy to dexmedetomidine or magnesium sulfate. * patients with a history of re-do surgery.
comparison of physiotherapy versus home exercise following hip replacement surgery

Conditions: Arthritis; Arthroscopic Hip Surgery

Summary: a randomized controlled trial of outpatient physiotherapy versus a self-administered home exercise program following discharge home from total hip arthroplasty


Eligibility criteria:
inclusion criteria: * primary tha (cemented or cementless) * preoperative diagnosis of osteoarthritis (primary or secondary) * meets objective discharge-to-home test following hip replacement * ability to speak english and reply to questionnaires written in english * ability to provide informed consent * may include patients presenting for their second primary hip arthroplasty discharge to home criteria * independent supine-to-sit transfer * independent sit-to-stand transfer * walk with walking aid 30 meters * ascend and descend 3 stairs * deemed medically fit and safe for home environment by surgeon/nursing/pt exclusion criteria: * surgery as part of a workers' compensation claim * arthroplasty performed for trauma or following open reduction and internal fixation, malignancy or inflammatory arthropathy * intra-operative complication of fracture or sciatic nerve injury * procedure requiring complex surgical approach other than posterior or anterolateral (ie trochanteric osteotomy/micro 2 incision approach) * indications for additional primary or revision arthroplasty within the time frame of the study (24 months) in other hip or knee joints which would adversely affect quality of life and functional scores pertaining to the joint of interest
performance assessment of the pmd-200 in subjects with degenerative lumbar spine disease who requires surgical procedure

Conditions: Degenerative Diseases, Nervous System

Summary: performance assessment of the pmd-200, a novel pain monitor, in subjects with degenerative lumbar spine disease who requires surgical procedure

the proposed study is design to further demonstrates the capability of the nociception level, (nol) index in identify and discriminate between painful event and non-painful period following pain stimulus of straight leg raising (slr) test in patients with degenerative lumbar spine disease. this feasibility study may provide first indication for a validation method that will be able to evaluate the outcome of a surgical procedure within the degenerative lumbar spine patient. currently, there is lack of understanding of long-term outcomes after such surgeries. in this study, the investigators plan to demonstrate that the nol index may serve as an indicator to the surgical procedure outcome. it will compare the objective measurement of the nol to the patient visual analogue scale (vas) score and disability questionnaire that will characterize the subject pain perception prior and following the surgical procedure.

Eligibility criteria:
inclusion criteria: * age over 18 and less than 65 (18 \< age \< 65). * the subject suffer from unilateral degenerative lumbar spine disease * the subject suffer from leg pain only in one leg, while no pain in the other leg. * the subject was hospitalized in the neurosurgery department of the hospital in order to undergoes spinal surgery due to the above disease * a signed informed consent form (icf) has been obtain from the subject exclusion criteria: * the subject has a bi-lateral degenerative lumbar spine disease * the subject is pregnant
may metformin be used in renal failure?

Conditions: Renal Disorder Associated With Type II Diabetes Mellitus

Summary: the study is to treat metformin dose-escalation diabetic subjects of all stages of renal failure (stages 1-5) and compare their rates of erythrocyte metformin (best reflections of a possible accumulation than those of plasma) to the therapeutic range. a number of 12 patients by stage is considered, 60 patients in total.


Eligibility criteria:
inclusion criteria: * diabetic patients not treated with metformin, no treatment diabetic or have been treated but poorly balanced (hba1c\> 7%) and an applicant building with metformin; at any stage renal stable (stages 1-5 according to the classification mdrd) * patients aged 18 to 80 years; * patients with an assessment of renal function dating back more than 3 months; * patients whose renal function is stable, on the criterion of the absence of fluctuation over 30% of renal function of creatinine clearance in the last three months, a reference to renal function at least 3 months from the balance sheet inclusion is necessary. exclusion criteria: * patient over 80 years * patients incapacitated adults (protected under guardianship) * no previous reference creatinine; * fluctuation over 30% of renal function (creatinine clearance) in the three months; * reduction in bmi of more than 5% during the last 3 months; * severe hepatic impairment (child stage\> a); * no reference to liver stages 3-5 * patients to be an x-ray with injection of contrast.
rsa study of persona tka with cr vs mc polyethylene

Conditions: Osteoarthritis, Knee

Summary: the aim of this study is to evaluate, over a 2 year period, the migration pattern, function and the possibility of anatomical reconstruction of a relatively new total knee arthroplasty (tka) concept, the persona. sixty patients will be randomized into 2 groups of 30 patients each, with one group receiving the persona tka with a conventional cruciate retaining (cr) polyethylene articular surface and the other group with a newly developed medial congruent (mc) articular surface. patients will be followed up with radiostereometry (rsa), conventional radiography, outcome questionnaires, clinical evaluation and computer tomography (ct). the migration pattern of the components will be evaluated as well as the degree of anatomical reconstruction and clinical result. we plan also to do a 5 year follow-up of the patients with rsa and proms.


Eligibility criteria:
inclusion criteria: * osteoarthritis of the knee necessitating knee replacement * asa i-iii * bmi 18 - 35 exclusion criteria: * joint sepsis in history * immunosuppresive drugs last 5 years * rheumatoid arthritis * severe osteoporosis or other metabolic bone diseases * neuromuscular diseases * personal disorders suspected of limiting rehab and completion of the trial period * previous osteotomy of affected limb * intra-articular knee fracture of affected limb * peroperative fracture * severe deformity of affected joint in need of augmentation or excessive release * obvious need for more constrained knee than cr

Keywords: radiostereometry (rsa) total knee arthroplasty
effect of natural antibacterial mouthwash on taste, salivary ph and bacteria in high caries risk pt

Conditions: Decay, Dental

Summary: evaluate the effect of propolis extract mouthwash and pomegranate extract mouthwash on taste alteration, salivary ph and antibacterial activity against streptococcus mutans in high caries risk patients.

this study will be carried out to evaluate and compare the effect of propolis extract mouthwash and pomegranate (botanical name: punica granatum) extract mouthwash on taste alteration, salivary ph and antibacterial activity against streptococcus mutans in high caries risk patients. thats by taking unstimulated saliva samples at the morning before using the mouthwash, then taking another one after using the mouthwash and finally after 7 days, to make a bacterial culture and measure the salivary ph by a digital ph meter and evaluate taste changes by a questionnaire.

Eligibility criteria:
inclusion criteria: * high caries risk patients defined according to american dental association (ada) * systematically healthy * not taking any medication interfering with saliva secretion * subjects who signed informed consent * age range from 17-50 years exclusion criteria: * subjects suffering from any medical or systematic disease * smokers * pregnant females * allergy to any of the mouthwash ingredients * patients older than 50 years
prevention program to reduce injury disparities among latino day laborers

Conditions: Work-related Injury

Summary: the purpose of this study is to identify intervention priorities using a corner-based needs assessment to document occupational and psychosocial risk and protective factors that increase latino day laborers(ldl) risk for injury and to design a culturally responsive and context appropriate occupational safety and health administration (osha) 10-based safety intervention that also addresses psychosocial risks to reduce ldl injuries and collaboratively pilot a corner-level intervention and conduct an evaluation to assess the safety program's feasibility and acceptability as determined by the extent to which we can recruit, retain and follow-up ldl over the course of the study.


Eligibility criteria:
inclusion criteria: * latino * identified at a "corner" located in the houston metropolitan area * currently looking for work at a corner exclusion criteria: * not of hispanic/latino background * being unable to participate in the survey due to alcohol or drug use impairment.

Keywords: latino day laborers
cascade testing in families with newly diagnosed hereditary breast and ovarian cancer syndrome

Conditions: BRCA-Mutated Ovarian Carcinoma; BRIP1 Gene Mutation; MSH2 A636P; MLH1 Gene Mutation; MSH6 Gene Mutation; PMS2 Gene Mutation; EPCAM; RAD51C Gene Mutation

Summary: identification of brca mutations in ovarian cancer patients may help guide cancer therapies, prognosis, post-operative screening, and other preventative treatments beyond the initial diagnosis. likewise, genetic testing of ovarian cancer patients for these germline mutations provides invaluable information for families regarding cancer risk, genetic testing, and subsequently indication for risk-reducing surgery. cascade testing provides a unique opportunity to identify carriers of a deleterious brca mutation which can allow for surgical and chemoprevention of prevention of ovarian cancer. there is currently no literature on the rates of referral for the family members.

the objective of this study is to perform a pilot study, offering referral to a genetic counseling and genetic testing for family members of a probands known to have a mutation in brca1 or brca2. in addition to brca1 and brca2, the nccn suggests consideration of risk-reducing surgery for mutations in brip1, msh2, mlh1, msh6, pms2, epcam, rad51c, rad51d, investigators will include these subjects as well in the study.

Eligibility criteria:
inclusion criteria: * all subjects must have a diagnosis of epithelial ovarian cancer, fallopian tube caner or primary peritoneal cancer with a known pathogenic genetic mutation. * all subjects must agree to participate. * all subjects must have first or second degree relatives who have not been diagnosed with the same genetic mutation. * a previous diagnosis of cancer in the subject's first or second degree relative is allowed. exclusion criteria: * subjects whose first and/or second degree relatives have already been tested with the subject's known mutations, and no other viable family members are available for testing.