Kornimate/medical-research-clean huggingface dataset:
dynamic and static splinting as a treatment for plantar faciiopathy

Conditions: Plantar Fasciitis; Plantar Fasciopathy

Summary: the purpose of this study is to compare the ankle dorsiflexion dynasplint system (ds) to static night splint for the reduction of pain from plantar fasciitis (fasciopathy).


Eligibility criteria:
inclusion criteria: * all patients will have had a history of at least 3 consecutive months of plantar heel pain well-localized to the plantar fascia. * all patients will have failed an initial treatment of non-weight bearing plantar and achilles stretching. * diagnosis will be confirmed by physical examination by a single physician (jpf) with a typical point of maximum tenderness over the medial tubercle of the calcaneus exclusion criteria: * rheumatoid arthritis * local infection * pregnancy * patients with tumors * unresolved fractures * severe peripheral vascular disease * history of prior plantar fascia surgery * history of plantar fascia rupture * age \<18 years * recent ( within 6 weeks) steroid injection

Keywords: pf dynasplint adfd afd plantar fasciitis plantar fasciopathy
establishment of human lung stem cell proliferation system and organoid construction in copd

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the goal of this study is to proliferate human lung stem cell in vitro in order to establish a lung organoid derived from patients with copd. the main question it aims to answer are: * can human lung stem cell proliferate in vitro. * can a lung organoid derived from patients with copd be established. participants will be sampled during pulmonary bronchoscope for organoid establishment.


Eligibility criteria:
inclusion criteria: * 1. age under 55, regardless of gender * 2. patients with copd lung disease who are going to undergo bronchoscopic biopsy * 3. no genetic diseases and other respiratory diseases exclusion criteria: * other conditions determined by the investigators to be unsuitable for inclusion, such as difficult sampling, difficult follow-up, and complicated with other serious diseases

Keywords: copd organoid human lung stem cells
evaluation of visual performance with contact lenses

Conditions: Myopia

Summary: this study will evaluate the influence of contact lens optical design on visual performance using standard and multifocal soft contact lenses (mfcls).

the study will examine visual acuity with various contact lenses, with and without glare source, in myopes between the ages of 18-39 years old (inclusive) to determine the effect of different multifocal optical designs on visual performance in the post-fit period.

Eligibility criteria:
inclusion criteria: * 18 to 39 years of age * best corrected visual acuity of at least 20/30 * spherical equivalent refractive error in each eye of between -0.75 and -6.00 diopters sphere after vertexing to the corneal plane exclusion criteria: * greater than -1.00 diopter of refractive astigmatism at the corneal plane * any active anterior segment disease, pathology, or surgery affecting vision, refraction, or the ability to wear a soft contact lens * history of ocular trauma or surgery causing abnormal or distorted vision * current rigid gas permeable (rgp) contact lens wearers * unwilling to have eyes photographed or video recorded * pregnant and/or lactating females, by self-report

Keywords: multifocal contact lens myopia visual performance
epidural catheter and surgically implanted rectus sheath catheter in management of postoperative pain

Conditions: Postoperative Pain

Summary: one hundred and twenty patients at age range from 18 to 60 undergoing laparotomy was enrolled in this study. patients were randomly assigned to two groups 60 in epidural group and the other 60 patients in rectus catheter group. epidural catheter inserted pre induction but rectus sheath catheter inserted by the surgeon at the end of surgery.

one hundred and twenty patients at age range from 18 to 60 undergoing laparotomy was enrolled in this study. patients were randomly assigned to two groups 60 in epidural group and the other 60 patients in rectus catheter group. epidural catheter inserted pre induction but rectus sheath catheter inserted by the surgeon at the end of surgery. in both groups we activated with10 ml bupivacain25% before patient recovery then 10 ml bupivacain.125% each 6 hours. if patient still in pain 1gm perflgan injected. if patient still in pain 10 mg nalufine for 70 kg patient injected. we will record pulse, blood pressure and visual analogue scale at 0,6,12,24 and 36 hours postoperative. also occurrence of nausea and vomiting, time of return of bowel movement, time of discharage and amount of analgesia used will be recorded. results, discution will be later.

Eligibility criteria:
inclusion criteria: * patients at age rang from 18 to 60 undergoing laparotomy * patients asa1,2 physical status exclusion criteria: * any known coagulopathy * morbid obesity * kyphosis or scoliosis * those with known sensitivity to local anesthetic drugs * lack of cooperation and inability to understand or perform verbal or physical assessments.

Keywords: rectus sheath catheter, pain following laparotomys.
effects of rehabilitation combined with a maintenance program compared to rehabilitation alone in post-covid-19

Conditions: Post-COVID-19 Syndrome

Summary: infection with sars-cov-2 virus leads to persistent symptoms for more than 12 weeks in 15% of cases ("post-covid syndrome"). symptoms like fatigue, dyspnoea, limitations in physical performance and activities, head ache, anxiety symptoms, and depression are heterogenous which limit physical health and participation in daily life activities. in the last years, multidisciplinary rehabilitation programs showed benefits in quality of life and symptom intensity in patients with post-covid. therefore, rehabilitation programs are recommended for individuals with post-covid by official sites like the german society of pulmonology and the european respiratory society. own first data (published at the ers conference 2023) revealed that one the one hand, inpatient rehabilitation is effective, however, on the other hand, it is challenging to maintain these effects after completing the program. therefore, the aim of this study is to sustain these benefits by using a digital maintenance program following the rehabilitation program compared to usual care.


Eligibility criteria:
inclusion criteria: * post-covid-syndrome (definition who) * entered the rehabilitation process at the schoen klinik berchtesgadener land exclusion criteria: * no internet access

Keywords: rehabilitation maintenance program
comparing efficacy and safety of cto0303 in pediatric subjects

Conditions: Pupillary Dilation Effect During Cycloplegic Refraction

Summary: this is a prospective randomized study compared with active control arm.

this is a prospective randomized study compared with active control arm. the investigators compare the pupil size in subject when 30 minutes after administering ip (cto0303 or active control).

Eligibility criteria:
inclusion criteria: * pediatric or adolescent subjects those who get a written consent both whom and their parents (or legally acceptable representative) * pediatric or adolescent subjects aged 4 to 15 years old based on date of written consent exclusion criteria: * subjects with a history of severe systemic reaction or increased sensitivity to atropine * subjects with anterior segment disease that interferes with ophthalmological examination (ex. corneal scar, corneal opacity and others) * subjects administered mydriatic medication within 14 days prior to administration of investigational product * subjects with contact lens

Keywords: pupillary dilation
length of hospital stay, nursing hours and recovery after laparoscopic versus open colon resection without fast track

Conditions: Sigmoid Neoplasms

Summary: a blinded randomized trial. length of hospital stay, nursing hours and recovery after laparoscopic versus open colonic resection without fast track.

context: our preliminary experience (unpublished) indicate that less nursing hours are needed after laparoscopic colon resection without fast track. length of hospital stay and recovery seems to be reduced as well. objektive: to compare laparoscopic and open colonic resection concerning nursing hours, length of hospital stay and recovery. design, setting and patients: triple blinded study (patient, nursing staff and data collector) including 2 x 12 patients needing sigmoid resection due to cancer. nursing hours, length of hospital stay and recovery (postoperative pain, questionnaire, actigraph ect.)

Eligibility criteria:
inclusion criteria: * sigmoid resection without stoma * sigmoid neoplasms localized 20 cm from anus * age 40-90 exclusion criteria: * conversion from laparoscopic to open surgery * stoma * severe postoperative complications (anastomosis leak, intraabdominal abscess, reoperation, stay at intensive care unit, heart attack, pulmonary embolism) * no informed consent

Keywords: nursing hours length of hospital stay reconvalescence colorectal surgery laparoscopic sigmoid neoplasms
effectiveness of transcutaneous electrical nerve stimulation in patients with acute low back pain

Conditions: Low Back Pain

Summary: introduction: low back pain is one of the most common complaints in doctors' offices, and acute low back pain is characterized by episodes of pain with less than three weeks duration. the transcutaneous electrical nerve stimulation (tens), based on the gate control theory of pain proposed by melzack and wall in 1965, has been used as an adjunctive therapy in the control of back pain, being a non-invasive, low cost, safe and easy to apply. no studies were found regarding the effectiveness of tens in acute low back pain. objective: to evaluate the effectiveness of tens in pain management of patients with acute low back pain. material and methods: a randomized clinical trial, double-blinded and placebo-controlled. patients were selected in the clinics of federal de university of sao paulo (unifesp) according to the following criteria: acute low back pain, both genders, aged between 18 and 65 years, pain between 4 and 8cm in pain numeric scale (pns) and who agreed to participate in the study. after signing the informed consent patients were randomly allocated into one of the groups: tens group (tg) or placebo group (pg). in tg was applied conventional tens with frequency and intensity variation (fiv) effect, frequency of 100 hertz, a pulse width of 60μs and intensity adjusted according to the individual baseline for each patient without causing muscular contraction. the electrodes were arranged in a cross shape in the paravertebral region (levels t12-l1 and l5 - s1). in pg the same procedures were adopted, but did not occur electrical stimulus. patients were informed that they could or could not feel electric shocks. treatment consisted of 10 sessions (2x / week / 5 weeks), with each session lasting 30 '. assessments were made at the following times: t0 (baseline), t1 to t10 (the beginning and end of each session), t11 (after the last session), t30 (30 days after the last session) and t60 (60 days after the last session). assessment tools: pns for pain, short-form 36 (sf-36), roland-morris, self-assessment of improvement ("likert" scale) and drug consumption (daily).


Eligibility criteria:
inclusion criteria: * acute low back pain * both genders * aged between 18 and 65 years * pain between 4 and 8cm in pns (pain numeric scale) * who agreed to participate in the study. exclusion criteria: * patients with pain of inflammatory, neoplastic or infectious origin, * with cardiac pacemaker, * previous back surgery, * signs of irritation of nerve roots, * vertebral fracture, which changed the physical activity in the last three months, * and pregnant women

Keywords: transcutaneous electric nerve stimulation pain
ono-4538 study in patients with advanced non-small cell lung cancer

Conditions: Advanced Non-small Cell Lung Cancer

Summary: the objective of the study is to investigate the safety and efficacy of ono-4538 in subjects with stage iiib/iv or recurrent non-small cell lung cancer unsuited to radical radiotherapy and resistant to a platinum-based chemotherapeutic regimen.


Eligibility criteria:
inclusion criteria: * male or female ≥ 20 years of age * histologically or cytologically confirmed non-small cell lung cancer * diagnosis of nsclc in stage iiib/iv unsuited to radical radiotherapy according to uicc-tnm classification (7th edition) or recurrent nsclc * has at least one measurable lesion, as defined by the recist guideline (version 1.1) exclusion criteria: * current or prior severe hypersensitivity to another antibody product * multiple primary cancers

Keywords: ono-4538 advanced non-small cell lung cancer
evaluation of silodosin and pelvic floor muscle training in men with benign prostatic hyperplasia and overactive bladder

Conditions: Benign Prostatic Hyperplasia (BPH); Overactive Bladder

Summary: this study will evaluate the efficacy of pelvic floor muscle training in men with benign prostatic hyperplasia and overactive bladder treated with silodosin.

this is a randomised-intervention, parallel, multicentre study which will evaluate the efficacy of pelvic floor muscle training in men with benign prostatic hyperplasia and overactive bladder treated with silodosin.

Eligibility criteria:
inclusion criteria: • willing to provide written informed consent * men over 50 years with lower urinary tract symptoms and overactive bladder and benign prostatic hyperplasia * persistence of overactive bladder despite 4 weeks of silodosin treatment * symptoms of overactive bladder (urinary frequency and urgency with or without urinary incontinence) for ≥3 months prior to visit 1. * willing and able to complete the 3-day voiding diary and questionnaires * international prostate symptom score (ipss) score ≥8. * experience an average of 8 or more micturition's per day over the 3-day diary period. * experience an average of 2 episodes of urgency per day (grade 3 or 4) over the 3-diary period exclusion criteria: * post-void residual volume (pvr) \>200 ml * evidence of urinary tract infection and haematuria * use anticholinergics, beta 3 mimetics within 4 weeks prior to visit 1 and during the study * oncological diseases of the lower urinary tract and prostate * neurogenic bladder * urethral strictures and bladder neck stenosis * urolithiasis * diabetes mellitus * previous surgery of lower urinary tract * stress urinary incontinence * intermittent catheterisation * chronic urinary tract infection * previous botox treatment in the last 12 months * chronic electrostimulation treatment of oab in the last 12 months * patient began or has changed a bladder training program or pelvic floor exercises less than 90 days before 1 visit * cognitive deficits and dementia * man has participated in an interventional trial within 30 days prior to visit 1 * total daily urine production over 2500 ml according to voiding diary

Keywords: benign prostatic hyperplasia overactive bladder silodosin pelvic floor muscle training
cascade clinical data collection protocol

Conditions: Intracranial Aneurysm

Summary: this study is a multi-center, single arm, open label, retrospective and prospective clinical data collection of cascadetm, non-occlusive remodeling net, in adults with intracranial aneurysms, demonstrating the effectiveness and safety of the cascadetm in providing temporary assistance for coil embolization of intracranial aneurysms. all consecutive eligible patients from all participating sites will be included in this clinical data collection. the relevant data of the coil embolization procedure will be collected via an ecrf system. peri procedural data on the coil embolization procedure as well as discharge, 30 days and at 3-6 months status will be collected.


Eligibility criteria:
patients must fulfill the following eligibility criteria to be included in the study: 1. patient has been treated or planned to be treated with cascade (cascade device was opened). 2. patient or patient's legally authorized representative or patient's family member (if approved by iec) has signed and dated an informed consent form (icf), unless icf is waived by local iec. 3. coil embolization procedure of intracranial aneurysm using temporary assisting device is initiated
value of using pioglitazone in chronic myeloid leukemia treatment

Conditions: Chronic Myelogenous Leukemia, BCR-ABL Positive; CML, Chronic Phase

Summary: assessment of patients response and expression levels of cited2 and hif2a genes on adding pioglitazone to imatinib therapy.

eligible denovo cml patients will be treated by combination drug therapy of imatinib 400 mg plus pioglitazone (15 - 30mg).they will be on follow up for their complete blood count (cbc), chemistry profile and random blood sugar every 2 weeks. after 3, 6 and 12 months of treatment the patients response will be evaluated and compared with the obtained responses of a historical control group. assessment of the hypoxia induced factor 2 alpha (hif2a) gene and cbp/p300-interacting transactivator with glutamic acid (e) and aspartic acid (d)-rich tail 2 (cited2) gene expression levels before and after 6 months of treatment will be additionally evaluated.

Eligibility criteria:
inclusion criteria: * cml cases (bcr-abl1 positive) exclusion criteria: * accelerated or blastic crisis * atypical cml (bcr-abl1 negative) * chronic myelomonocytic leukemia (cmml) * pregnant or breastfeeding females. * patients with severe organ dysfunction
impact of kidney failure on the regulation of humoral response to vaccination

Conditions: Chronic Kidney Disease Requiring Chronic Dialysis; Vaccine Response

Summary: the aim of this observational study is to determine if and how kidney failure affects the development of protective immune responses following vaccination in patients on chronic dialysis. researchers will compare the effectiveness of the influenza vaccine in inducing protective antibodies between hemodialysis patients and subjects without chronic kidney disease. participants will: * be enrolled at the time of influenza vaccination * visit the clinic at 7, 14, 30, 60, and 120 days after vaccination * be asked to provide relevant clinical information and a blood sample at each visit


Eligibility criteria:
inclusion criteria: * age between 18 and 70 years * patients undergoing thrice-weekly hemodialysis / peritoneal dialysis for at least 3 months or healthy individuals without a history of renal insufficiency * subjects eligible to receive a seasonal influenza vaccine * signed informed consent for participation in the study exclusion criteria: * recent influenza infection (clinically resolved less than 3 months ago). * administration of immunosuppressive drugs in the two weeks prior to vaccination. * administration of another vaccine in the three weeks prior to enrollment (co-administration of other vaccines with those under study does not contraindicate participation). * systemic infection clinically resolved less than two weeks before enrollment.

Keywords: vaccine influenza chronic kidney disease hemodialysis peritoneal dialysis humoral response
sonodynamic therapy in the treatment of carotid atherosclerosis

Conditions: Carotid Atherosclerosis

Summary: sonodynamic therapy (sdt) is a new treatment for carotid atherosclerotic plaque. the purpose of this study is to evaluate the safety and initial effectiveness of this technique.

carotid atherosclerotic plaque is an important cause of ischemic stroke. treatments for patients with carotid plaque include lifestyle changes, medical management(such as control of hyperlipidemia, hypertension, and diabetes) and carotid revascularization(carotid endarterectomy or carotid artery stenting). studies have suggested that plaque morphology and composition are important determinants of plaque stability, using serial mr imaging of the carotid artery allowed observation of changes in plaque composition. contrast enhanced ultrasound (ceus) is a well accepted technique for detection of intraplaque neovascularization(ipn) in carotid atherosclerotic disease. the purpose of this trial is to evaluate the safety and initial effectiveness of sdt. the sdt can induce macrophage elimination and inhibit matrix degradation, which will promote plaque lipid depletion, inflammation level decrease and changes in other plaque tissue components, leading to plaque stabilization and reduction.

Eligibility criteria:
inclusion criteria: * age 18- 80 years * carotid artery with 30%\~70% stenosis by ultrasound and plaque thickness\>2.5mm * patients without transient ischemic attack, minor stroke or amaurosis fugax within 6 months * patients' ldl-c level below 100 mg/dl(2.6mmol/l), well-controlled blood pressure(systolic bp\<140 and diastolic bp\<90 under resting conditions) and diabetes(hba1c\<7%) * written informed consent exclusion criteria: * non-atherosclerotic carotid artery stenosis * contraindication to mri( uses pacemaker, has metallic implants, claustrophobia) * acute mi, acute coronary syndrome or stroke within 4 weeks prior to visit * severe cerebral artery stenosis, atrial fibrillation or mri detected thrombosis that would cause stroke * previous significant adverse reaction to a statin * systemic disorders such as hepatic, renal, hematologic, and malignant disease * medical history that might limit the individual's ability to take trial treatments for the duration of the study * allergic to dvdms or sonovue * diagnosis of porphyria * pregnant women and nursing mothers * history of bilateral carotid endarterectomy or has immediate plans for carotid endarterectomy * patient who is attending other clinical trial
the easytrak epi clinical investigation

Conditions: Bradycardia; Congestive Heart Failure

Summary: the purpose of this study is to assess the safety and effectiveness of the easytrak epi lead.

this is a prospective, single-armed, multi-center u.s., australian, canadian, and european clinical investigation, designed to demonstrate the safety and effectiveness of the easytrak epi lead in humans.

Eligibility criteria:
inclusion criteria: * patients who meet the easytrak epi indications * patients who are age 18 or above, or of legal age to give informed consent specific to state and national law * patients who are willing and capable of providing informed consent, undergoing a device implant, participating in all testing associated with this clinical investigation at an approved clinical investigational center and at the intervals defined by this protocol * patients who meet any one of the following three conditions: * meet current indications for cardiac resynchronization therapy (crt) and epicardial placement of a pace/sense lead on the left ventricle is preferred over an endocardial lead * meet current indications for a cardiac pacing system and have documented evidence that an endocardial lead cannot be used * meet current indications for a cardiac pacing system and a concurrent cardiac surgical procedure is taking place where no additional surgical procedures are required to provide access to the epicardial surface of the heart exclusion criteria: * patients who meet the easytrak epi contraindications * patients who have had a myocardial infarct, unstable angina, or percutaneous coronary intervention during the preceding 30 days prior to enrollment * patients with a documented life expectancy of less than 6 months or expected to undergo heart transplant within the next 6 months * patients enrolled in any concurrent study, without guidant written approval, that may confound the results of this study * women who are pregnant or plan to become pregnant

Keywords: artificial cardiac pacing implanted electrodes