Kornimate/medical-research-clean huggingface dataset:
clinical application of pulse rate-monitoring activity trackers in thyrotoxicosis

Conditions: Thyrotoxicosis; Graves Disease; Thyroiditis

Summary: the study is a single-center prospective cohort study of clinical application of continuously monitored data by wearable activity trackers in the patients with thyrotoxicosis. the purpose of the study is to evaluate the association between parameters of pulse rate, activity, and sleep from wearable activity trackers and the thyrotoxic status along with the treatment.

activity trackers to be used: fitbit charge hr (tm) data which ware provided by fitbit app (tm) will be analyzed in this study.

Eligibility criteria:
inclusion criteria: * patients undergoing newly developed or recurrent thyrotoxicosis who are treated and followed-up in seoul national university bundang hospital * patients who can use wearable activity trackers and smartphone applications * in case of graves' disease, patients who will treated by anti-thyroid drugs exclusion criteria: * patients who have thyrotoxic periodic paralysis * in case of graves' disease, patients who will treated by radioactive iodine therapy or thyroidectomy * patients who have thyrotoxicosis due to toxic nodular disease

Keywords: wearable activity tracker thyrotoxicosis
post-stroke neural plasticity with atomoxetine

Conditions: Atomoxetine Hydrochloride; Placebos

Summary: this proposal evaluates the safety and effectiveness of a noradrenergic drug named atomoxetine combined with motor training to enhance cortical plasticity and improve hand function after stroke.

extensive studies in laboratory animals and humans over the last ten years indicate that some medications, especially amphetamine, given with specific physical therapy may improve motor learning (and therefore recovery from stroke) more than physical therapy alone. however, the number of patients in clinical trials who have received physical therapy and amphetamine is very small, for two reasons: because amphetamine may interact with many other medications that stroke patients are already taking, and because its potential for addiction precludes its use on a daily basis. the investigators now wish to evaluate the effectiveness of a more selective medication, atomoxetine, known to have many fewer side effects and no potential for drug addiction. the proposed mechanism by which amphetamine enhances recovery is by increasing central levels of norepinephrine. while the investigators already know that this drug is more selective than amphetamine, the investigators would like to evaluate its effects on hand motor learning and motor recovery in chronic stroke patients in a clinical setting.

Eligibility criteria:
inclusion criteria: * chronic stroke patients * single stroke * chronic (more than 6 months after from stroke) * at least 21 years old, but there is no upper age range for this project. * participants not able to extend the affected metacarpophalangeal joints at least 10° and the wrist 20°. exclusion criteria: * history of head injury with loss of consciousness * history of severe alcohol or drug abuse * history of psychiatric illness * unstable cardiac dysrhythmia * high blood pressure (systolic pressure \>160 mm hg and/or diastolic pressure \>100 mm hg) * history of myocardial infarction or unstable angina * pregnancy * glaucoma, history of hypersensitivity or idiosyncrasy to sympathomimetic drugs. * subjects using drugs suspected of interfering with plasticity, such as maoi, alpha-adrenergic antagonists, benzodiazepines, muscarinic receptor antagonists, dopaminergic antagonists, or other neuroleptics within 3 months of recruitment.

Keywords: motor training motor recovery human neuroplasticity transcranial magnetic stimulation
expanded access of pemigatinib to treat a single patient with metastatic pancreatic cancer


Summary: expanded access of pemigatinib to treat a single patient with metastatic pancreatic cancer.


Eligibility criteria:
inclusion criteria: - exclusion criteria: -
the use of thoraco-lumbo-sacral orthoses (tlsos) in the treatment of adolescent idiopathic scoliosis (ais)

Conditions: Scoliosis

Summary: the purpose of this study is to compare the risk of curve progression in adolescent idiopathic scoliosis for subjects treated with bracing as compared to those without bracing.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of ais * age ≥10, ≤15 years old * risser 0, 1 or 2 * primary cobb angle between 20 and 40 degrees (inclusive) * apex (of at least one of the primary curves) caudal to t7 * pre-menarchal or post-menarchal by ≤1 year * physical and mental ability to adhere to bracing protocol exclusion criteria: * diagnosis of other musculoskeletal or developmental illnesses possibly responsible for the curvature * a history of previous surgical or orthotic treatment * inability to read and understand chinese

Keywords: adolescent idiopathic scoliosis scoliosis ais brace tlso
orofacial functions in individuals with and without molar incisor hypomineralization

Conditions: Molar Hypomineralization, Incisor

Summary: molar incisor hypomineralization (mih) is a qualitative developmental defect of the enamel with a complex, multifactorial nature and a significant genetic component that predominantly affects the permanent first molars and, occasionally, the permanent incisors. individuals with mih have a compromised stomatognathic system manifested by muscle hyperactivity under postural and dynamic conditions. however, there is a gap in knowledge on the specific functional abnormalities that these individuals experience. early identification and intervention, with a focus on the prevention of orofacial dysfunctions and deviations in facial growth and development, are aspects of the utmost importance. therefore, the aim of the proposed study is to perform a comparative analysis of orofacial functions with an emphasis on breathing and chewing patterns in individuals with and without mih. methods and analysis: assessments will be performed using the nordic orofacial test - screening (not-s). descriptive statistics will be performed and comparisons will be made using the chi-square test, adopting a 5% significance level.


Eligibility criteria:
inclusion criteria: * children 6 to 12 years of age with a complete mixed dentition with all first molars present and in occlusion; * having all first molars erupted, without caries or previous treatment; * inclusion criteria for the mih group: at least one permanent molar with indices compatible with mih (code 2, 21, 22 and 3 - ghanim criteria). exclusion criteria: * children with amelogenesis and dentinogenesis imperfecta; * children undergoing orthodontic treatment; * children with a genetic syndrome; * children with the premature loss of deciduous teeth; * children with acute respiratory problems; * children in treatment.
transcranial doppler in children with hemoglobinopathies

Conditions: Hemoglobinopathies

Summary: transcranial doppler ultrasonography (tcd) is a noninvasive, portable technique for evaluating the intracranial vasculature. tcd ultrasonography is performed placing a low frequency (≤ 2 mhz) transducer on the scalp of the patient, in order to visualize the intracranial arterial vessels through specific acoustic windows, where bone is thinner, and evaluate cerebral blood flow velocity (cbfv) . patients diagnosed to have hemoglobinopathy conditions with its most common forms thalassemia and sickle cell disease manifest both biochemical and clinical evidence of hypercoagulability conditions include deep venous thrombosis, pulmonary emboli and recurrent arterial occlusion . cerebrovascular accidents can be identified using transcranial doppler ultrasonography which enables evaluation of cerebral artery blood flow velocity with a sensitivity of 90% and specificity of 100 % when compared with cerebral angiography . according to the stroke prevention trial in sickle cell anemia (stop) study ,tcds were classified based on blood velocity in the circle of willis, expressed as time averaged mean of the maximum velocity (tammv). children with abnormal, high velocities (\>200cm/s) were at increased risk of stroke, which was reduced by 90% after starting regular blood transfusions. tammvs less than 170cm/s were classified as normal with annual tcd scanning recommended, whereas velocities between 170 and 200cm/s were called conditional, and followed up more closely without starting transfusion.


Eligibility criteria:
inclusion criteria: * children diagnosed with hemoglobinopathies exclusion criteria: * children before two years old . * hemoglobinopathy patients more than 18 years . * uncooperative patients .
sodium sources and sodium intake in a representative sample of spanish children

Conditions: Urinary Sodium Excretion; Salt Intakes; Body Weight

Summary: previous evidence shows that sodium intake in spanish adult population is over the recommended limits and this high sodium intake is related with difficulties in body weight control and blood pressure control. the aim of this study is to stablish a direct relationship between salt intake and the health parameters previously mentioned in a representative sample of spanish schoolchildren between 7-11 years old. the investigators are applying a 3-day dietary records to collect dietary data, and collecting 24-h urine samples in order to analyse biochemical indicators of sodium intake and other nutrients. anthropometric data are also being recorded and body composition is also analysed using bioimpedance technique.

specific aims 1. to stablish the average sodium intake in spanish children, using a 24-h urine sample and validated dietary questionnaires. 2. to compare 24-hour urinary sodium measurement to the dietary survey method 3. to study the relationship between sodium intake and blood pressure levels in spanish scholars. 4. to analyze the relationship between sodium intake and overweight/obesity in spanish children using anthropometric and bioimpedance analysis measures. 5. to identify main food sources of sodium in the diet of spanish schoolchildren and the use of discretionary salt. 6. provide new data for monitoring sodium intake in spanish schoolchildren and design campaigns to reduce their intake. 7. to provide reference data of sodium intake on a representative sample of the spanish child population for european and international databases.

Eligibility criteria:
inclusion criteria: * age between 7 and 11 years old exclusion criteria: * those who have any clinical problem, which may modify the results of the analysis: metabolic or chronic diseases (liver, kidney, diabetes, hypothesis or hyperkalemia), pharmacological treatment during the 3 months prior to the study with corticosteroids, insulin, diuretics or other drugs that may modify blood pressure figures, surgery or serious infectious diseases in the previous 6 months. * those who were not in the school when the measures were taken.

Keywords: child health sodium intake food sources blood pressure bmi urinary sodium excretion
nutritional and metabolic evaluation of a tube feeding immune enhancing diet in icu patients

Conditions: Neurological Diseases; Pneumopathy; Major Abdominal Surgery; Acute Pancreatitis

Summary: comparison of metabolic and nutritional effects of an enteral immune enhancing diet with those of a standard polymeric one, in icu patients


Eligibility criteria:
inclusion criteria: * 18\ 10 * requiring the administration of an exclusive tube feeding nutrition during 7 days and beginning at the latest in the three days following the aggression * icu patients hospitalized for: * neurologic affections * pneumopathy * major abdominal surgery or serious acute pancreatitis * written informed consent exclusion criteria: * pregnancy or breast feeding * immunosuppressive therapy * radiotherapy or chemotherapy in the last six month * uncontrolled septic choc * auto-immune disease * hepatic,renal or digestive insufficiency * hyperlipidemia * diabetes mellitus type 1 * digestive malabsorption * life threatening situation * treatments with growing hormone, glutamine or its metabolites or precursors such as ornithine alpha keto glutarate

Keywords: icu patients
abdominal mr imaging at 3.0t: sequence optimization and implementation

Conditions: Diffuse and Focal Abnormalities of the Liver and Pancreas

Summary: this project will facilitate the optimization of body mr imaging at 3 tesla.

this project is meant to improve the image quality of multiple sequences at 3.0t applied to the abdominal and pelvic regions.

Eligibility criteria:
inclusion criteria: * subjects between ages of 19 and 65 * healthy volunteer subjects should not have any history of disease or symptoms - based on clinical history * subjects with an underlying disorder (diffuse and focal abnormalities of the liver and pancreas) exclusion criteria: * inability to provide informed consent * a medical or contraindications that will prevent subjects from having a mri * subjects with severe renal dysfunction or patients on dialysis
post abortion iud & recurrent abortion 2005-2006

Conditions: Induced Abortion

Summary: the rate of repeat abortions will be lowest in those women who choose immediate insertion of an iud post-abortion versus those who immediately choose oral contraceptive pills and those who indicate all other contraceptive choices including no contraception the provision by the health system of iuds for immediate insertion will result in the lowest health system costs.

the investigators intend to demonstrate whether there are statistically significant differences in the rates of repeat abortions between three groups: 1. women choosing to have an intrauterine device (iud) inserted immediately post-abortion, 2. those choosing to begin oral contraceptives immediately post-abortion, and 3. all other choices for post abortion contraception including those stating an intention to obtain contraceptives at a later time or from an alternate location or to use no contraception. this data will then be used to conduct a cost-effectiveness analysis of health system provision for cost-free iuds post-abortion. thus, if providing a free iud immediately post-abortion significantly reduces the rate of repeat abortions, it may be more cost- effective for health system services to provide free iuds at abortion clinics than to field the costs associated with a higher rate of repeat abortions. the researchers will conduct a retrospective observational cohort study by chart review. the researchers propose to review the charts of women undergoing abortions between january 1, 2005 and december 31, 2006 at kelowna general hospital's women's services clinic. the researchers will record the following data from each chart: age, parity, gestational age, date of index therapeutic abortion (ta), dates of subsequent tas, contraception used at the time of the index conception, contraceptive method chosen post-abortion, and outcome of follow-up at two weeks, such as expulsion of iud. the researchers will also record the recurrent pregnancy rates.

Eligibility criteria:
inclusion criteria: * female resident of interior health region seeking an abortion between january 1, 2005 and december 31, 2006 exclusion criteria: * women undergoing abortions for fetal genetic abnormalities

Keywords: abortion rate intrauterine device
study of human leukocyte antigen (hla) polymorphisms in patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: rheumatoid arthritis (ra), affects between 0.3% and 1.0% of the population, it can lead to progressive joint destruction and severe disability. to date, two ra genetic susceptibility factors have been identified: hla-drb1-se (shared epitope) and ptpn22 620w alleles. the predictive value of the alleles for diagnosis of ra was previously investigated in cohorts of caucasians patients with early unclassified arthritis that showed restrained association between ra and hla-se. despite the contribution of hla to the overall genetic risk has been estimated to range from 30% to 50%, it has never been studied in the french west-indian population.


Eligibility criteria:
inclusion criteria: * diagnosis of rheumatoid arthritis according to acr criteria * come from french west indies (at least 3 grandparents are african-caribbean) * sign written informed consent exclusion criteria: * minor * patient with no rheumatoid arthritis according to acr criteria * patient does not agree for a genetic study for the control inclusion criteria: * blood donor * sign written informed consent * patient with no rheumatoid arthritis according to acr criteria * come from french west indies (at least 3 grandparents are african-caribbean) exclusion criteria: * minor * patient does not agree for a genetic study

Keywords: rheumatoid arthritis rheumatoid arthritis according to acr criteria of diagnosis
noninvasive assessment of cerebral oxygenation and cardiac function in patients with neurovascular diseases

Conditions: Subarachnoid Hemorrhage, Aneurysmal

Summary: this prospective observational study will assess the regional cerebral oxygen saturation and cardiac output non-invasively in patients with subarachnoid hemorrhage during nimodipine administration for the prevention/management of cerebral vasospasm.


Eligibility criteria:
inclusion criteria: * aneurysmal subarachnoid hemorrhage * potential or actual cerebral vasospasm exclusion criteria: * non-aneurysmal subarachnoid hemorrhage * outside the 4-21 day window after ictus * peripheral deoxygenation * contraindication for nimodipine administration

Keywords: cerebral vasospasm nimodipine
efficacy and safety of egalet-002 in patients with moderate-to-severe chronic low back pain

Conditions: Moderate-to-severe Chronic Low Back Pain

Summary: the purpose of this study is to determine the analgesic efficacy of egalet-002 twice daily (bid) in patients with moderate-to-severe chronic low back pain


Eligibility criteria:
inclusion criteria: * is an english-speaking man or woman between 18 and 75 years of age who has given written informed consent. * has a clinical diagnosis of moderate-to-severe low back pain (quebec task force class 1 to 3) for ≥6 months. * is opioid naïve (ie, taking \<20 mg oxycodone/day or opioid equivalent) or is opioid experienced (ie, taking a dose between 20 and 240 mg \[inclusive\] oxycodone/day or opioid equivalent) for management of moderate-to-severe clbp at least 14 days prior to screening and will, in the opinion of the investigator, continue to require opioid therapy (between 20 and 240 mg oxycodone/day, inclusive) for management of moderate-to-severe clbp for the duration of the study. * has stable health, as determined by the investigator, * if female, the patient is currently not pregnant, not breast-feeding, nor attempting to become pregnant (for 30 days before screening and throughout the duration of the study), or is of non-childbearing potential exclusion criteria: * has cancer-related pain. * has a history of receiving \>240 mg oxycodone (or equivalent) daily within 30 days before screening. * has a lumbar spinal infusion pump in use or used within 6 months before screening. * has clinically unstable cardiac disease (including atrial fibrillation, symptomatic bradycardia, unstable congestive heart failure, or active myocardial ischemia) * has positive urine drug toxicity screen for illegal or non-prescribed drugs * has current (or history of within the last 5 years prior to screening) drug dependence or substance abuse disorder according to diagnostic and statistical manual of mental disorders, 5th edition, text revision criteria (excluding nicotine). * has positive result for cannabinoids (even if legally prescribed). * has a history of attempted suicide.
study of glucose in dialysis water with regard to blood pressure and quality of life

Conditions: Hemodialysis

Summary: we wanted to test the hypotheses that blood pressure level was lower, that the variability of blood pressure and blood glucose was reduced, and that quality of life was improved when glucose was added to the dialysis fluid.

the purpose of the study was to determine the effect of glucose added to the dialysis fluid on 1.blood pressure and variation in blood pressure, 2.blood glucose and variation in blood glucose, and 3.quality of life in patients treated with chronic maintenance hemodialysis in a randomized, placebo-controlled, unblinded cross-over study.

Eligibility criteria:
inclusion criteria: * age more than 18 years, both men and women, and hemodialysis treatment for more than three months exclusion criteria: * treatment with hemodiafiltration, change to another dialysis modality, renal transplantation, alcohol abuse defined as more than 21 drinks a week for men and more than 14 drinks a week for women, and unwillingness to participate.

Keywords: blood pressure; chronic renal failure; diabetes mellitus; dialysis fluid; glucose; hemodialysis; hypertension; uremia.
tendency to suicide as a sequel of computer vision syndrome

Conditions: Computer Vision Syndrome

Summary: cvs-f4 questionnaire will be used as an instrument to survey prevalence of tendency to suicide among medical students in the egyptian universities and analyse associated risk factors and any correlated determents

cvs-f4 (30 questions) will be an online survey via the surveymonkey company. we will collect the responses and analyze the results. informed consent will be obtained from the participants as an item within the survey itself that he/she agrees to use his/her data in this research work. the questionnaire includes questions regarding potential ocular, extra-ocular, musclo-skeletal and neuro-psychatric complains caused by cvs. cvs-f4 questionnaire will be used as an instrument to survey prevalence of tendency to suicide among medical students in the egyptian universities and analyse associated risk factors and any correlated determents complete statistical analysis of the survey data will be done using univariate and multivariate logistic and linear regression analysis.

Eligibility criteria:
inclusion criteria: * university students * university staff members exclusion criteria: * hysteria * ocular surgery * amblyopia * anisometropia * strabismus * systemic disease
ventricular remodeling in patients with aortic stenosis assessed echocardiography

Conditions: Aortic Stenosis

Summary: this preliminary study will compare the effectiveness of two-dimensional and three-dimensional echocardiographic measurements of wall thickness and left ventricular mass in patients with aortic stenosis

this study will evaluate left ventricular patterns of remodeling and hypertrophy in patients with aortic stenosis, and compare two-dimensional echocardiography measurements (wall thickness) with three-dimensional echocardiography data(left ventricular mass). along with a second objective to assess doppler diastolic filling indices associated with the various patterns of left ventricular remodeling. previous studies(see reference list) were primarily derived from two-dimensional echo data set(based on wall thickness). various patterns of left ventricular remodeling have been described in response to increased pressure overload. three-dimensional echocardiography is a relatively new technique that is being increasingly used in the echocardiography lab in selected patients. this technique holds promise of being more accurate for volume-related measurements than the standard 2-dimensional echocardiography techniques.

Eligibility criteria:
inclusion criteria: * subjects more than 18 yrs of age through 90 yrs of age * both male and female * patients with moderate or severe isolated aortic stenosis * patients who have been referred for both two-dimensional and three- dimensional echocardiographies. exclusion criteria: * poor acoustic windows * h/o cad and wall motion abnormality

Keywords: aortic stenosis valvular heart disease heart disease cardiovascular disease two dimensional echocardiography three dimensional echocardiography