Kornimate/medical-research-clean huggingface dataset:
the effect of different exercises on lower extremity performance in flexible flatfoot

Conditions: Flexible Flatfoot

Summary: in the study, the effects of two different strengthening exercises combined with short foot exercise on lower extremity functional performance and muscle strength will be examined and compared in adults aged 18-45 years with flexible flatfoot. this study was designed as an experimental, 3-arm, parallel group, double-blind randomized controlled study that included a 6-week intervention period.

participants will be randomly divided into 3 different groups (control group, foot-ankle exercise group, hip exercise group). the control group will be instructed to perform only short foot exercise; the foot-ankle exercise group will be instructed to perform 3-dimensional foot-ankle extension exercise in proprioceptive neuromuscular facilitation (pnf) pattern in addition to short foot exercise; the hip exercise group will be instructed to perform hip abductor and external rotator muscle strengthening exercise (clam exercise) in addition to short foot exercise. foot-ankle and hip exercises will be performed against resistance with the help of an elastic band, 3 days a week under the supervision of a physiotherapist and progression will be made by changing to a higher level of difficulty band color every 2 weeks. short foot exercise will be performed every day of the week (3 days under the supervision of a physiotherapist; the rest of the days as a home exercise program) and will be progressed by changing position (sitting, standing, on one leg respectively) every 2 weeks. all exercises will be performed for 6 weeks. assessments will be performed at the beginning and end of the exercises by another researcher blinded to group allocation. isometric muscle strength of the intrinsic foot, four-way ankle circumference and hip abductor-external rotator muscles, endurance of the plantar flexors, forward jump and dynamic balance performance will be evaluated respectively.

Eligibility criteria:
inclusion criteria: * age range is 18-45 years * navicular drop is 10 mm or more * getting a value of +6 points or more from the foot posture index-6 exclusion criteria: * orthopedic and rheumatological diseases of the spinal region and lower extremities * surgery history of the spine and lower extremities * neurological and systemic disorders * describe lower extremity and/or lower back pain in the last 6 months * disorders that may affect cognition and balance (otitis media, visual impairment, etc.) * body mass index being above normal values (18-24.9 kg/m2) * having rigid flat feet and/or hallux rigidus-limitus deformity * being involved in regular sports or exercise * having received any physiotherapy or rehabilitation treatment for flat feet or hips in the last year

Keywords: foot deformities intrinsic foot muscle training muscle strenghening short-foot exercises performance proprioceptive neuromuscular facilitation
prediction of clinical outcome in thoracic espb

Conditions: Pain, Chronic

Summary: the primary endpoint of this study was to identify that perfusion index (pi) has any predictive value for the treatment outcome of cervical radiculopathy

the erector spinae plane block (espb) is a less invasive, safer, and technically easy alternative procedure to conventional neuraxial anesthetic techniques. in contrast to common neuraxial techniques such as paravertebral and epidural injections, the espb targets an interfascial plane which is far from the spinal cord, root, and pleura. first applied to thoracic neuropathic pain, currently espb is being applied to postoperative pain control and includes variable clinical situations. in the abdomen and thoracic wall, thoracic espb can be applied for pain control after cardiac surgery, video-assisted thoracic surgery, laparoscopic cholecystectomy, and thoracotomy. recently, favorable postoperative pain control after lumbar spinal or lower limb surgeries has been reported with lumbar espb. in addition, espb has also been used for chronic pain conditions in the upper and lower extremities. the perfusion index (pi) is a numerical value for the ratio between pulsatile and non-pulsatile blood flow measured by a special pulse oximeter. although the special probe for pi measurement is relatively more expensive compared with ordinary pulse oximetery probes, its benefit as a marker of peripheral perfusion and as an idex for sympathetic stimulation have increased its use progressively. pi has been used widely for the prediction of success of brachial plexus block or axillary block. changes of pi ratio value showed an excellent predictive value for the success of block. there have been no studies demonstrating predictive value of pi in thoracic espb for the relief of cervical radiulopathy

Eligibility criteria:
inclusion criteria: * cervical foraminal stenosis * cervical central stenosis * cerivcal disc herniation * cervical spondylolisthesis exclusion criteria: * infection * pregnancy * allergy to local anesthetic agents * previous cervical spine surgery
comparison of topical antiviral agents for labial cold sores (herpes labialis)

Conditions: Reccurent Herpes Labialis

Summary: recurrent cold sores - herpes simplex labialis (hsl) occurs in 20-40% of the us population and patient seek treatment because of the discomfort and visibility of the lesion although it is a self limiting disease. the purpose of this study is to check the safety, efficacy and convenience of use of the natural agent "superlysin gel" as treatment for herpes labialis in comparison to acyclovir 5% and docozanole 10%.

study design: -double blinded non-inferiority prospective parallel-group, intend to treat trial. enrolment of 75 patients (25 randomized for each group). - approval of the institutional ethical review board - study design: - patient characteristics (selected) and historical information assessment including: race, average episode duration from patient history duration of most recent previous episode time since last onset of oral-facial herpes simplex time since first onset of oral-facial herpes simplex does patient experience localized prodrome? * experiment duration; 5 to 10 days * 4 visits (days 1, 3,6,10) * 5 application /day for each derivative * documentation metric digital images of localized area signs at each visit clinical assessment of prodrome/erythema, papule, vesicle, ulcer, crust, or healed skin (with or without residual erythema) visual analogue scale (vas) for subjective assessment of pain, burning, itching or tingling at each visit * calculation of primary efficacy end point (time to healing); from the date and time of the initiation of therapy until the date and time of the clinic visit at which complete resolution of all local signs and symptoms, i.e. the lesion had aborted or complete healing had occurred (censored at day 10)

Eligibility criteria:
inclusion criteria: * signed informed consent * age range (yrs) 18-70 * gender ; males and females * health status; immuno-competent * clinical history of hsl with at least two recurrences during the past 12 months. the most recent previous episode must have healed at least 14 days before screening. * less than 12 hours after prodrome initiation (i.e. local erythema w/o blistering, tingling and or burning sensation, soreness) exclusion criteria: * pregnant women * mentally disabled * no intra-oral lesions, or lesions above the nostrils and below the chin * no topical steroid use and no systemic antiviral current treatments within 7 days before the study * no known allergies to topical cosmetics * no use cosmetics on or around the mouth during the treatment period * no concomitant use of systemic corticosteroids or other drugs known to induce immune stimulation or immune suppression
medication adherence in psoriatic arthritis

Conditions: Psoriatic Arthritis

Summary: psoriatic arthritis (psa) is a chronic multisystemic disease requiring ordinary doctor visits and an adherence to medication. evaluating the parameters affecting the medication adherence is essential for the efficacy of the treatment. to our knowledge no study has ever evaluated the factors affecting the medication adherence in patients with psa so far.

psoriatic arthritis (psa) is a multisystemic disease requiring ordinary doctor visits and an adherence to medication. due to its chronic nature treatment regimens lasts for the lifetime and that may affect the efficacy of the treatment. although treatment with drugs is a biological intervention, medication adherence and eliminating the factors affecting it seems essential for treatment efficacy. to our knowledge no study has ever evaluated the factors affecting the medication adherence in patients with psa so far. our aim in this study is to evaluate the factors affecting the medication adherence in patients with psa.

Eligibility criteria:
inclusion criteria: * diagnosed with psa according to caspar criteria * administering psa medication for at least 6 moths * aged ≥18 exclusion criteria: * not having enough cognitive functions to understand and answer the questionnaires * having a psychiatric disorder * having a severe comorbidity (e.g. malignancy, stroke)

Keywords: psoriatic arthritis medication adherence
azygos vein preservation; its impact on early outcomes after neonatal ea/tof repair

Conditions: Azygos Vein Preservation Versus Disconnection; Tracheo-Esophageal Fistula With Atresia of Esophagus; Leak, Anastomotic; Stricture Esophagus; Pneumonitis; Postoperative

Summary: azygos vein preservation revisited: impact on early outcomes after repair of esophageal atresia/ tracheo-esophageal fistula in newborns. a randomized controlled study.

since the first successful repair of esophageal atresia/tracheoesophageal fistula was performed approximately eight decades ago, surgeons have made considerable technical advances in solving intraoperative surgical challenges and reducing postoperative complications. according to some surgeons, the advantage of maintaining the azygos vein makes this modification attractive. this study aimed to explore the benefits of retaining the azygos vein during surgery for esophageal atresia with tracheoesophageal fistula, to emphasize its advantages in terms of reducing anastomotic leak, stricture, and other postoperative outcomes. patients and methods: this prospective randomized study was conducted between april 2020 and april 2023. the study included all newborns with (ea \& tef) eligible for primary repair, patients were randomly assigned to either group a or group b. (group a) patients who underwent azygos vein preservation during tef repair, whereas the remaining patients (group b) had azygos vein disconnection. statistical analysis: the statistical package for social sciences (spss) (version 23.0, ibm corp ibm corp., armonk, ny, usa) was used for statistical analysis. the chi-square test (x2) was used to compare qualitative data in the groups, while an independent-sample t-test was used to compare quantitative data between groups. the degree of confidence was set at 95%. the p-value was considered significant at a level of 0.05. discussion: will focus on advantages of azygous vein preservation on intactness of esophageal anastomosis, retaining the venous drainage of the bronchial system, and chest wall. points of discussion will include effects of azygous vein preservation on incidence of postoperative pneumonitis, anastomotic leakage and stricture rate, and mortality rate. the results obtained from this study will be compared between both groups and with those reported in the literature. finally, the investigators will conclude the reconstructive technique that gives the better results and least morbidity.

Eligibility criteria:
inclusion criteria: * all neonates suitable for primary repair of esophageal atresia and tracheoesophageal fistula exclusion criteria: * long gap esophageal atresia (\> 3 cm) * esophageal atresia without tracheoesophageal fistula

Keywords: esophageal atresia, tracheoesophageal fistula, preservation of the azygos vein, division of azygos vein, pediatrics
feasibility and metabolic effects of a 5:2 fasting intervention in women with breast cancer during radiotherapy

Conditions: Breast Cancer

Summary: the intervention consists of the adoption of a 5:2 intermittent fasting diet during radiotherapy of breast cancer patients. the aim of the study was to assess the feasibility of this intervention and its impact on body composition and selected metabolic blood parameters.

the 5:2 intermittent fasting (fast) intervention consisted of two nonconsecutive days of fasting per week that could be chosen freely according to the patient's weekly schedule. the minimum amount of time to count as a fasting day was 24 hours, but patients were advised to aim for a complete fasting day including the nights before and after that day. on a fasting day, only water and unsweetened tea or coffee was allowed. however, given that fat is the macronutrient interfering the least with the metabolic adaptions to fasting, while carbohydrates disturb the most \[26\], patients were allowed to consume small amounts of bone broth/meat broth, coconut oil, butter/ghee or heavy cream as an "emergency plan", i.e., in case that they felt they needed some energy-containing foods to complete an initiated fasting day. the primary study outcome was the feasibility of the fast intervention and its effects on longitudinal body composition changes from baseline until the final week of radiotherapy (body mass, fat mass, fat-free mass, muscle mass, extracellular and total body water). secondary endpoints were absolute changes in metabolic parameters, hormones, and overall quality of life scores in the fast group. as a surrogate marker for insulin resistance, the triglyceride-glucose index (tyg) was calculated according to tyg=ln⁡(fasting triglycerides \[mg/dl\]×fasting glucose \[mg/dl\]/ 2).

Eligibility criteria:
inclusion criteria: * non-metastasized breast cancer * indication for curative radiotherapy exclusion criteria: * metallic body parts that would interfere with electric bioimpedance (bia) measurements * difficulties with understanding the aims of the study
phase ii study of intra-operative electron irradiation and external beam irradiation after lumpectomy in patients with t1n0m0 and t2n0m0 breast cancer

Conditions: Breast Cancer

Summary: the study is being done to determine the tolerance to single fraction intra-operative electron irradiation (ioert) and external beam photon irradiation (ebrt) following lumpectomy for t1/t2n0m0 breast cancer. ioert is used in lieu of the 5-8 days of electron beam boost irradiation that is usually given after ebrt. data from two centers as well as preliminary data from a randomized trial in europe suggest that ioert boost is well tolerated and efficacious. in our study, patients will undergo standard lumpectomy and sentinel lymph node sampling or axillary dissection. after the lumpectomy, ioert of 10 gy will be delivered in a single fraction to the tumor bed by a mobile electron machine in the operating room. ebrt to the whole breast will be administered once the surgical wound has healed adequately. the primary objective is to determine the feasibility and acute patient tolerance to ioert and ebrt after lumpectomy. secondary objectives include assessment of local control and distant control of disease, as well as evaluation of long-term side effects and cosmetic outcome of the treatment.


Eligibility criteria:
eligibility: 1. histologically proven primary invasive breast carcinoma. 2. tumor pathologically determined \<= 5cm in diameter. 3. single, discrete, well-defined primary tumor. 4. any micro-calcifications must be focal. a specimen radiograph is required after lumpectomy to assure removal of all malignant appearing calcifications. 5. pathologically negative surgical margins. 6. axillary lymph node status can be determined by level i and ii lymph node dissection or sentinel lymph node sampling. 7. ecog performance status 0-2. contraindications: 1. multicentric disease and/or diffuse malignant appearing microcalcifications. 2. evidence of metastatic breast cancer. 3. axillary lymph node involvement. 4. pre-existing collagen vascular disease except rheumatoid arthritis that does not require immunosuppressive therapy. 5. prior irradiation to the ara of planned radiation field. 6. pregnant or lactating women.
pilot study to estimate the burden and distribution of plasmodium falciparum malaria in kalifabougou, mali in preparation for a prospective cohort study of naturally-acquired malaria immunity

Conditions: Malaria, Falciparum; Plasmodium Falciparum

Summary: plasmodium falciparum malaria remains a global public health threat. leading malaria vaccine candidates confer only partial short-lived protection at best. an understanding of the mechanisms by which humans acquire malaria immunity through repeated p. falciparum infections may aid the development of a malaria vaccine. this pilor study is designed to initiate the epidemiological groundwork for a future prospective cohort study of acquired malaria immunity in kalifabougou, mali, a rural village of approximately 5 000 individuals who are exposed to seasonal p. falciparum transmission each year from july through december. this study will estimate the age-stratified point prevalence of p. falciparum infection before the malaria season and at the peak of the 6-month malaria season, and it will estimate the age-stratified incidence of symptomatic p. falciparum infection during the 6-month malaria season. the spatial distribution of asymptomatic p. falciparum infections and incident malaria cases within the village of kalifabougou will be determined by merging the prevalence and incidence data with census and global positioning system (gps) data....

plasmodium falciparum malaria remains a global public health threat. leading malaria vaccine candidates confer only partial short-lived protection at best. an understanding of the mechanisms by which humans acquire malaria immunity through repeated p. falciparum infections may aid the development of a malaria vaccine. this pilor study is designed to initiate the epidemiological groundwork for a future prospective cohort study of acquired malaria immunity in kalifabougou, mali, a rural village of approximately 5 000 individuals who are exposed to seasonal p. falciparum transmission each year from july through december. this study will estimate the age-stratified point prevalence of p. falciparum infection before the malaria season and at the peak of the 6-month malaria season, and it will estimate the age-stratified incidence of symptomatic p. falciparum infection during the 6-month malaria season. the spatial distribution of asymptomatic p. falciparum infections and incident malaria cases within the village of kalifabougou will be determined by merging the prevalence and incidence data with census and global positioning system (gps) data.

Eligibility criteria:
* inclusion criteria: cross-sectional survey: individuals (ages 2-25 years) are eligible to enter the cross-sectional study if they agree to: * live in kalifabougou for the next 5 months. * have blood specimens stored for future studies. passive surveillance: all individuals who live in kalifabougou and present to the kalifabougou health center with suspected malaria will be eligible to enroll in the passive surveillance component of the protocol. exclusion criteria: none.

Keywords: prevalence incidence children adults global positioning system
tangningtongluo tablet in the treatment of non-proliferative diabetic retinopathy

Conditions: Type2 Diabetes; Diabetic Retinopathy

Summary: this trial is planned to collect relevant clinical data to evaluate the prevention efficacy and safety of tangningtongluo tablets on the non-proliferation period of diabetic retinopathy.

after being informed about the study and potential risks,all patients giving written informed consent will undergo a 1-week screening period to eligibility for study entry.at week 0,patients who meet the eligibility requirements will be randomized into two groups(experimental group and control group)in a 1:1 ratio to tangningtongluo tablets(4 tablets,tid,po.) or calcium dobesilate capsules(1 capsule,tid,po.).

Eligibility criteria:
inclusion criteria: * 1. patients with the diagnosis of type 2 diabetes. * 2. patients with the diagnosis of non-proliferative diabetic retinopathy and the classified as mild and moderate. * 3. target eye best corrected vision acuity (bcva) ≥ 34 points (etdrs vision chart, vision equivalent of score 20 / 200, decimal 0.1). * 4. patients who meet the syndrome differentiation standards of yin asthenia generating intrinsic heat and eye collateral stasis in traditional chinese medicine. * 5. hba1c ≤ 9%. * 6. age between 18 and 75 years old * 7. informed consent, voluntary subject. the process of obtaining informed consent form complies with good clinical practice(gcp). exclusion criteria: * 1. patient with the diagnosis of diabetic retinopathy is combined with severe vitreous blood effusion, or required total retinal laser treatment or vitrectomy. * 2. patient who has been treated with full retinal laser photocoagulation. * 3. patient with difficulty in evaluating fundus images with refractive medium turbidity. * 4. patient was diagnosed of acute metabolic disorders such as diabetic ketoacidosis or combined with severe acute infection in the past 1 month. * 5. patient with other serious diabetes complications, such as diabetes gangrene. * 6. patient was allergic to tangningtongluo tablets, or calcium dobesilate, or its composition. * 7. female patient with pregnancy, or prepare for pregnancy, or lactating. * 8. patient with serious cardiovascular, liver, kidney or hematopoietic system disease, and mental diseases. * 9. liver and renal function (alanine aminotransferase (alt) or aspartate aminotransferase (ast) above 2 x upper limit of normal (uln)and cr\> above 1 x upper limit of normal (uln)). the diabetic nephropathy stage was 4 and above. * 10. patient with eye diseases such as glaucoma, uveitis, optic neuropathy, and severe cataract. * 11. patient participated in other clinical researches within a month.

Keywords: diabetes retinopathy tangningtongluo tablets
efficacy of weekly versus daily folic acid supplementation

Conditions: Neural Tube Defects

Summary: investigate the efficacy of weekly versus daily of folic acid supplementation on improving folate, vitamin b12,

460 women of a rural community in the western highlands of guatemala were recruited for participation in the double-blinded study led by emory university and the institute of nutrition of central america and panama (incap). the women were randomly assigned one of 4 vitamin treatments containing different levels of folic acid, vitamin b12, iron and zinc. the treatments were as follows: 1. weekly dose of folic acid at 5000ug, iron at 120 mg, zinc at 30mg, and b12 at 16.8 ug; 2. weekly dose of folic acid at 2800ug, iron at 120mg, zinc at 0mg and b12 at 16.8ug; 3. daily dose of folic acid at 400ug, iron at 60mg, zinc at 15mg, b12 at 2.4ug; and 4. daily dose of folic acid at 200ug, iron at 50mg, zinc at 0mg, and b12 at 2.4ug. the women, aged 15-49, received the vitamins daily for 3 months. anthropometric data and blood samples were taken at baseline and post-supplementation. the participants also completed a series of dietary interviews at baseline and post-intervention. no pregnant or lactating mothers were admitted into the study, nor severely anemic females. blood samples were sent to the national laboratory in cuernavaca, mexico, for analysis of serum folate levels.

Eligibility criteria:
inclusion criteria: * female * aged 15-49 exclusion criteria: * pregnant * lactating less than 3 months * severely anemic