Kornimate/medical-research-clean huggingface dataset:
effect of therapeutic diet with physiotherapy on gross motor and cognition of autistic children

Conditions: Autistic Spectrum Disorder

Summary: : a clinical trial will be conducted to investigate the effect of free-gluten/ casein diet along with specific physiotherapy program on gross motor development and cognitive function in 3-12 years old children with asd, and thus establish a streamlining of nutrition and physical activity for children with autism and asd.

autism is a complex neurological and developmental disability that appears within early developmental stages of life. autism affects the normal functioning of the brain, communication development as well as social skills of the child. autism has been regarded as a life-long condition and it cannot be cured. however, severity may decrease through special diet and physiotherapy program. in saudi arabia, the prevalence revealed that confirmed cases of asd were 42,500, and many remained undiagnosed a target group of (60) children diagnosed with autism or asd, attending the paediatric psychiatry outpatient clinic and autism centres will be enrolled in this clinical trial study, which will be conducted in jazan city-saudi arabia. the inclusion criteria will be as follows: (1) parental consent, (2) age 3-12 years, and (3) a diagnosis of autism or asd. exclusion criteria were as follows: (1) autism associated with a genetic syndrome, (2) patients with comorbidities (3) known food allergy leading to avoidance of certain foods, and (4) mother or primary caretaker not available to be adherent to the prescribed diet. three groups will be designed: (1) autistic children with regular diet and physiotherapy program. (2) autistic children on free gluten/casein diet and (3) autistic children on free gluten/casein diet and subjected to specific physiotherapy program. the study will be continued for 3 months.

Eligibility criteria:
inclusion criteria: * children diagnosed with autism spectrum disorders. * gmfcs 4 exclusion criteria: * autistic children with any musculoskeletal deformities. * autistic children with any bulbar affection lead to problem in swallowing.
corticosteroids and myocardial injury in cap (colosseum trial)

Conditions: Community-acquired Pneumonia

Summary: community-acquired pneumonia (cap) is often complicated by elevation of cardiac troponin, a marker of myocardial injury, that can be isolated or associated to myocardial infarction (mi). a retrospective study showed that corticosteroid treatment lowers incidence of mi during the hospital-stay. the aim of this clinical trial is to examine whether in-hospital treatment with iv methylprednisolone (20 mg b.i.d) may reduce myocardial injury, as assessed by serum high-sensitivity cardiac t troponin) and eventually cardiovascular events during a short- and long-term follow-up in patients hospitalized cap.

background. community-acquired pneumonia (cap) is often complicated by elevation of cardiac troponin, a marker of myocardial injury, that can be isolated or associated to myocardial infarction (mi). a retrospective study showed that corticosteroid treatment lowers incidence of mi during the hospital-stay. no data exist so far on the effect of corticosteroids on myocardial injury in cap patients. study design. double-blind randomized placebo-controlled trial. one hundred twenty-two eligible patients will be randomized to a week treatment with iv methylprednisolone (20 mg b.i.d) or placebo from hospital admission. serum hs-ctnt will be measured at admission and every day until up 3 days from admission. ecg will be monitored every day until discharge. after dismission, all patients will be followed-up 2 years. aims of the study. primary objective of the study is to evaluate if methylprednisolone is able to reduce myocardial injury, as assessed by serum high-sensitivity cardiac t troponin (hs-ctnt), in a cohort of patients hospitalized for cap. secondary aims are to evaluate the potential effect of methylprednisolone on cardiovascular events during hospitalization, at 30 day from hospital admission and during 2 years' follow-up. the trial will also examine whether the potential protective effects of methylprednisolone might be due to platelet activation down-regulation.

Eligibility criteria:
inclusion criteria: hospitalization for community-acquired pneumonia exclusion criteria: 1. use of corticosteroids in the previous 30 days 2. health care-associated pneumonia 3. reported severe immunosuppression (human immunodeficiency virus infection, immunosuppressive conditions or medications) 4. preexisting medical condition with a life expectancy of less than 3 months 5. uncontrolled diabetes mellitus 6. gastritis with or without major gastrointestinal bleeding within 3 months 7. any condition requiring acute treatment with glucocorticoids

Keywords: corticosteroids
optimizing (breathing) techniques for radiotherapy of esophageal and lung carcinomas

Conditions: Esophageal Cancer; Lung Cancer

Summary: neo-adjuvant chemoradiotherapy (neo-crt) is increasingly applied in the curative treatment of esophageal cancer, with the aim to downstage the tumor, to increase the rate of radical resections, and consequently to improve the survival rates. due to improved survival, it will become increasingly important to minimize the radiation-induced toxicity among long-term survivors. in the management of locally advanced non small cell lung cancer (nsclc), radiotherapy is the standard treatment modality. however, the dose that can be safely applied to the tumour is limited by the risk of cardiac and pulmonary complications, which even led to decreased survival in a randomised study, when a higher tumor dose was administered \[1\]. radiation induced pulmonary and cardiac toxicity are the most important late side effects after thoracic radiotherapy \[2-4\]. the aim of this study is to reduce the radiation dose of heart (and lungs) in order to reduce the toxicity risk. in recent years, the active breathing control (abc) technique has been introduced in the radiotherapy for left sided breast cancer patients, to minimize the radiation dose to the heart. these patients are irradiated in the inspiration phase, in which the distance between the heart and the breast is largest, while the lungs extend. breath hold might also be beneficial for radiotherapy of esophageal and lung tumors. for these patients the expiratory phase might theoretically be more beneficial to reduce the heart dose. however, the inspiration phase might be better for the dose to the lungs, which consequently allows cardiac dose reduction.


Eligibility criteria:
inclusion criteria: * histologically proven esophageal cancer (adeno-, or squamous cell carcinoma) of the mid or distal esophagus or stage iii nsclc (any histological subtype). * scheduled for external-beam photon radiotherapy with curative intention. * who 0-2. * age \>= 18 years * written informed consent. exclusion criteria: * serious respiratory distress * noncompliance with any of the inclusion criteria.

Keywords: radiotherapy active breathing control technique
effect of catheter on postoperative urinary retention

Conditions: Transforaminal Lumbar Interbody Fusion

Summary: to determine if indwelling foley placement at the onset of the procedure, straight catherization at the conclusion of the procedure, or no catheterization produces the lowest rates of postoperative urinary retention after transforaminal lumbar interbody fusions (tlifs).

post-operative urinary retention (pour) is one the most common post-operative complications after elective spine surgeries. common causes of postoperative urinary retention (pour) include bladder stenosis, distension, trauma due to catheterizations, age, and prostate hyperplasia. the incidence of pour increases with age, gender, types of surgery conducted, any comorbidities such as cerebral palsy or multiple sclerosis, use of drugs such as anticholinergic agents, beta blockers, or sympathomimetics, and use of iv fluids. this condition has been associated with the development of utis and sepsis, increased post-operative length of stay (los), and 90-day readmission after surgery. in the field of spine surgery, the reported incidence of pour is highly variable, and there is no consensus on effective methods of prevention. we set out to assess pour from patients catheterized compared to non-catheterized following a transforaminal lumbar interbody fusion.

Eligibility criteria:
inclusion criteria: * patients undergoing a primary single-level mis tlif (diagnosis: radiculopathy, stenosis, herniated nucleus pulposus, degenerative disc disease, spondylosis, osteophytic complexes, spondylolysis, spondylolisthesis) * patients able to provide informed consent exclusion criteria: * patients with baseline urinary dysfunction requiring manual bladder emptying via intermittent straight catheterization, suprapubic catheters, or other indwelling catheters. -allergies or other contraindications to medicines in the post- operative urinary retention protocol * lack of consent
the effect of stomach acid on foscarnet

Conditions: HIV Infections

Summary: to see if ranitidine, by reducing stomach acidity, can enhance the effectiveness of foscarnet, by making foscarnet more available to the body. foscarnet is an antiviral compound. laboratory studies have shown it to be active against hiv. however, only 12 - 22 percent of an oral foscarnet dose is absorbed by the body. ranitidine suppresses gastric acid output, increasing gastric ph. thus by increasing gastric ph (decreasing stomach acidity), less foscarnet is expected to be decomposed or broken down in the stomach. thus, more foscarnet should be absorbed into the body.

foscarnet is an antiviral compound. laboratory studies have shown it to be active against hiv. however, only 12 - 22 percent of an oral foscarnet dose is absorbed by the body. ranitidine suppresses gastric acid output, increasing gastric ph. thus by increasing gastric ph (decreasing stomach acidity), less foscarnet is expected to be decomposed or broken down in the stomach. thus, more foscarnet should be absorbed into the body. six asymptomatic hiv-infected males, or those with limited symptoms of early aids-related complex ( arc ), will receive one dose intravenously of ranitidine in distilled water and one dose of placebo (distilled water alone), followed in 1 hour by foscarnet in oral solution. the order of ranitidine and placebo is randomized and the two foscarnet doses are separated by at least 72 hours. a nasogastric ph probe is placed on each morning of drug administration to monitor gastric ph.

Eligibility criteria:
inclusion criteria concurrent medication: allowed: * acetaminophen and sedatives. patient must be able to give informed consent. exclusion criteria patients with the following are excluded: * unintentional weight loss in excess of 10 pounds or 10 percent of usual body weight within 2 years prior to study. * unexplained temperature above 38 degrees celsius on more than 5 consecutive days or on more than 10 days in any 30 days in 2 years prior to expected study entry. * unexplained diarrhea defined by two or more stools/day for at least 14 days during a 120-day interval. prior medication: excluded within 1 week of entry into study: * probenecid, aspirin, or diuretics.

Keywords: ranitidine phosphorus acids drug evaluation acquired immunodeficiency syndrome
open label, 4 week study of itca 650 in adults with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: evaluate the safety and tolerability of itca 650 in subjects with type 2 diabetes mellitus.


Eligibility criteria:
inclusion criteria: * type 2 diabetes \>6 months * stable diet \& exercise, metformin, tzd or met + tzd hba1c \>6.5% \<10.0% exclusion criteria: * prior treatment with exenatide * history of pancreatitis * history of medullary thyroid cancer or multiple endocrine neoplasia 2
relationship between quality of life, life satisfaction and anxiety levels of wheelchair basketball players

Conditions: Quality of Life; Life Satisfaction; Anxiety Levels

Summary: today, there are many studies on wheelchair basketball players. however, these studies do not indicate the relationship between the quality of life, life satisfaction and anxiety levels of wheelchair basketball players, in the extent of the knowledge. as a result of this study, it is aimed to obtain information about the quality of life, life satisfaction and anxiety levels of wheelchair basketball players.

the study aimed to examine the relationship between the quality of life, life satisfaction and anxiety levels of wheelchair basketball players. this study was carried out with wheelchair basketball players in istanbul between march 2022 and may 2022. twenty-three wheelchair basketball players were included in the study. the scope of the study was explained to the wheelchair basketball players who participated in the study during the face-to-face interview, and the consent forms prepared by the researcher were distributed. the participants, who approved the consent form and agreed to participate in the study, had to fill out the sociodemographic form. the quality of life of the participants was determined by the sf-12 quality of life scale; satisfaction with life was evaluated with the satisfaction with life scale, and anxiety levels were evaluated with the beck anxiety scale. statistics were performed using spss version 22.0 program.

Eligibility criteria:
inclusion criteria: * being between the age of 18-45 * participating in a wheelchair basketball team regularly * being disabled regardless of the disability score exclusion criteria: ● being over the age of 45
molecular, histologic, and clinical analysis of negative pressure wound therapy (npwt) for split-thickness skin graft (stsg) donor sites

Conditions: Split-thickness Skin Graft Donor Sites; Burns

Summary: the purpose of this single-center, randomized, prospective cohort study is to evaluate the clinical outcome and negative-pressure wound therapy (npwt) mediated modulation of the biologic milieu of a modified npwt dressing on split-thickness skin graft (stsg) donor sites.

the investigators have designed a prospective randomized trial in which subjects will be assigned to a modified negative-pressure wound therapy (npwt) dressing or standard moist dressing. the investigators will measure the percentage of re-epithelization at set postoperative time intervals using digital photography, pain using the visual analog scale (vas), and healing quality using the vancouver scar scale (vss). the investigators hypothesize that the npwt will lead to less pain and increased re-epithelization in a shorter postoperative time course. this specific aim seeks to prove/disprove that patients who receive a modified npwt dressing perceive the advantage with improved healing, pain, shorter length of stay, and other wound symptoms related to delayed donor site wound healing. the donor site for stsgs provides a consistent model of superficial wounds that offers the opportunity to study both mechanisms of wound healing and potential mechanisms of action of npwt. in patients undergoing both standard dressings and npwt, the investigators will sample the wound exudate and perform microbiopsies of the healing wound at fixed intervals and perform histologic and molecular analysis in order to quantify the degree of re-epithelization and the trophic and inflammatory profile of the healing wound.

Eligibility criteria:
inclusion criteria: * age 18-60 * both genders are eligible for study * written consent obtained from the subject or agent * donor site wounds must not exceed 5% total body surface area (tbsa) * subject must be receiving a split-thickness skin graft (stsg) * donor site is amenable to either npwt or standard of care (occlusive dressing) * ability to comply with necessary wound care/follow up exclusion criteria: * age \<18 years * subject has been diagnosed with diabetes * subject is a smoker * subject takes steroids * subject takes immunosuppressive medications * subject with immunosuppressive disorders * donor site wounds that exceed 5% total body surface area (tbsa) * subject has sensitivity to silver or acrylic adhesives * inability to comply with necessary wound care/follow up.

Keywords: split-thickness skin graft stsg donor site negative-pressure wound therapy npwt dressing
fecal microbiota in preterm birth

Conditions: Gut Microbiome

Summary: we will compeer fecal microbiome in preterm birth with fecal microbiome of team labor


Eligibility criteria:
inclusion criteria: * woman after vaginal delivery of singleton exclusion criteria: * fetal abnormalities * gestational diabetes * hypertensive disorder
bordetella pertussis carriage in college-aged students

Conditions: Carriage of Bordetella Pertussis

Summary: the objective in this observational cohort study of young adults sampled at three intervals during the academic year is to ascertain if there is carriage of b. pertussis in asymptomatic individuals. we hypothesize that in asymptomatic college students there is no carriage of b. pertussis detectable by polymerase chain reaction (pcr) assay.


Eligibility criteria:
inclusion criteria: * age 18 and above * not immunosuppressed * not hiv positive (not known to be/self-reported) * able to tolerate swab procedures * able to provide consent exclusion criteria: * no antimicrobial or immunosuppressive medications taken for chronic conditions

Keywords: bordetella pertussis carriage rates in young adults
effects of dry needling on muscle function in patients with hip osteoarthritis

Conditions: Osteoarthritis

Summary: the aim of this study was to assess the effects of dry needling technique on muscle strength and muscle length in patients with hip osteoarthritis at short term.


Eligibility criteria:
inclusion criteria: * diagnosed medically with a x-ray test * american college of rheumatology criteria exclusion criteria: * secondary osteoarthritis by a traumatism, paget disease, inflammatory or metabolic disease, congenital diseases etc. * vascular or neurological disease. * musculoskeletal pathologies in lumbar spine, pelvis or lower limbs * fear of needles
tace combined with pd-1 knockout engineered t cell in advanced hepatocellular carcinoma.

Conditions: Advanced Hepatocellular Carcinoma

Summary: this study will evaluate the safety and effect of transcatheter arterial chemoembolization (tace)combined with percutaneous transhepatic pd-1 knockout engineered t cell infusion in the paitents with advanced hepatocellular carcinoma(hcc). blood and tissue samples will also be collected for research purposes.

this is a clinical study to investigate the safety and effect of transcatheter arterial chemoembolization (tace) in combination with pd-1 knockout engineered t cells in the paitents with advanced hepatocellular carcinoma. tace would block the blood supply of the tumor to achieve ischemic, hypoxic andnecrotic effects. the pd-1 knockout engineered t cells were also prepared from autologous origin using crispr cas9 technology. the patients performed one tace treatment followed by 3 cycles of pd-1 edited t cells by percutaneous infusion in the peripheral of tumor under the guide of ct every four weeks. the safety and clinical efficacy will be evaluated. biomarkers and immunological markers will be monitored.

Eligibility criteria:
inclusion criteria: 1. patients with unresectable hepatocellular carcinoma; 2. more than 18 years old; 3. patients diagnosed with hepatocellular carcinoma by histopathology or imagings; 4. liver function childpugh ≤7 points, physical strength score ecog-pts 0-1 points; 5. maximum tumor diameter ≤10cm, tumor number ≤10, no vascular invasion or extrahepatic metastasis; 6. other organs of the whole body function well; 7. sign the informed consent; 8. passed the review by the ethics committee. exclusion criteria: 1. less than 18 or more than 70 years old; 2. lack of autonomous decision-making ability; 3. ecog score \>2, cachexia or multiple organ failure; 4. metastases; the tumor was diffuse or metastasized widely and the expected survival time was less than 3 months. 5. uncorrectable coagulation dysfunction with a history of bleeding; organ transplant; 6. patients with severe autoimmune diseases; iodine contrast agent allergy; high allergic constitution; 7. the main portal vein was completely blocked by cancer embolism, with little collateral vascular formation; 8. severe infection; aids, syphilis infection; 9. t cell lymphoma; 10. patients with mental illness, severe trauma or other stress conditions; 11. pregnant or nursing women; 12. abnormal peripheral blood routine detection; 13. failing to comply with the study protocol to complete the diagnosis and treatment project; failed ethics committee review.

Keywords: crispr cas 9 tace pd-1 knockout engineered t cells advanced hepatocellular carcinoma locally administered treatment
hemodynamic monitoring during abdominal aortic surgery

Conditions: Hemodynamic Instability

Summary: this trial investigates the ability of our istitutional algorithm in maintaining a safe hemodynamics during abdominal aorta open surgery, in terms of limitation of intraoperative hypotension incidence

the present trial includes patients submitted to abdominal aorta open surgery. this type of procedure is very challenging for the hemodynamic management because of the operation per se (during which the surgeon clamp and unclamp the aorta with very significant hemodynamic variations) and because of the altered tone of the vessels due to the general vascular disease such a type of patients is suffering from. the aim of this study is to verify if the incidence of intraoperative hypotension in terms of severity, lasting and number of episodes, may be reduced by the application of a protocol of hemodynamic management. primary endpoint: global time spent in hypotension \<10%. secondary endpoints: 1. time weighted average (twa) of area under the threshold \<0.4 mmhg 2. incidence of hypotensive events/patient \< 8 (including the expected hypotensive events due to the aortic clamping and unclamping)

Eligibility criteria:
inclusion criteria: * adults patients undergoing abdominal aorta open surgical repair exclusion criteria: * emergent/urgent operation * age \<18 years * pregnancy * intra-operative blood loss \> or = 3000ml
effects of red light led therapy on body contouring

Conditions: Obesity

Summary: the purpose of this study is to determine whether red light therapy using led 650nm red light for body contouring of the waist, hips and thighs is as effective as red light therapy using laser 635nm red light.

red light laser therapy using 635nm red light laser technology has previously been shown to cause lipolysis in subcutaneous fat as a non-surgical method to promote weight loss and body contouring. this study hypothesizes that red led light therapy using 650nm red light led (light emitting diode) technology produces similar results to the laser device (red laser 635nm) when preformed using a specified treatment protocol. furthermore, it is hypothesized that the vevazz therapy program achieves the results after a single 28 minute treatment. the predicate 635nm led device (photonica professional by ward photonics) achieves its results after one 32 minute therapy program. the vevazz therapy program uses the vevazz led device for fat removal using led red light therapy. this multi-site study reviews results from 66 randomly selected patients after a single treatment using the vevazz led device.

Eligibility criteria:
inclusion criteria: * at least 18 years or older. * may be male or female. * generally good health. exclusion criteria: * minors. * open wounds or sores. * pacemaker. * photosensitivity. * epilepsy. * any form of cancer. * severe kidney or liver problems. * thyroid problems. * pregnant or nursing.