Kornimate/medical-research-clean huggingface dataset:
use of high sensitivity cardiac troponin in ruling out emergency patients with acute myocardial injury and infarction

Conditions: Acute Myocardial Infarction; Acute Coronary Syndrome

Summary: examine the analytical and clinical performance of atellica im tnih assay for the diagnosis and rule out of acute myocardial injury and myocardial infarction in patients presenting to the emergency department in whom serial ctni measurements are obtained on clinical indication.

background: studies addressing the clinical performance of the siemens healthineers high-sensitivity troponin i assay (tnih) on the atellica im analyzer for the diagnosis and rule out of acute myocardial injury and myocardial infarction in consecutive patients presenting to a united states (us) emergency department are lacking. study objective: examine the analytical and clinical performance of atellica im tnih assay for the diagnosis and rule out of acute myocardial injury and myocardial infarction in patients presenting to the emergency department in whom serial ctni measurements are obtained on clinical indication. hypothesis: the atellica im tnih assay will offer an excellent diagnostic performance for acute myocardial injury and acute myocardial infarction, as well as expedite the risk stratification of patients for early discharge from the emergency department.

Eligibility criteria:
inclusion criteria: 1. baseline ctn measurement and at least one additional ctn measurement within 6 hours after initial measurement. 2. at least one 12-lead electrocardiogram exclusion criteria: 1. less than 18 years old 2. pregnancy 3. trauma 4. decline to participate 5. did not present through the ed 6. transferred from an outside hospital or clinic.

Keywords: troponin high-sensitivity cardiac troponin acute myocardial infarction siemens atellica
the relation of ankle mobility and achilles tendon, plantar fascia and iliotibial band mechanical properties

Conditions: Mobility Limitation; Stiffness of Right Ankle, Not Elsewhere Classified; Stiffness of Left Ankle, Not Elsewhere Classified; Tone Increased, Muscle

Summary: the myotonometric assessment is becoming popular and important in athletic population. it is mentioned an alternate method than expensive methods, and it is easy and reliable assessment. still there is not enough information of mechanical characteristics in athletic population and ankle mobility. most clinicians or trainers can use this results and technique for enhancing performance, rehabilitation or prevention

the soft tissue mechanical properties can be assessed through elastography and ultrasonography. both methods can measure passive and active soft tissue properties. these methods are the gold standard to measure stiffness and elasticity, but they are expensive, operator dependent and need a laboratory settings.recently, myotonometric device has been used to measure the mechanical properties of the muscles and tendons. this method serves many advantages, such as non-invasive, painless and cost-effective. there is an increasing literature on athletic training about how training effects viscoelastic properties. however, to the best of our knowledge, there were no studies assessing stiffness and elasticity of at, pf and itb and the relation with ankle mobility in different sport disciplines. the purpose of this study were to demonstrate the mechanical properties of at, pf and itb and find out relation with restricted ankle mobility in athletes.

Eligibility criteria:
inclusion criteria: * being a professional athlete * right dominant * not having any lower extremity injury or surgery in the last 6 months, * following routine training program. exclusion criteria: * a history of strain or surgery with knee or ankle, * had any neurological or systemic disease.

Keywords: stiffness tone elasticity ankle mobility
a study for image-guided radiation therapy in pediatric brain tumors and side effects

Conditions: Central Nervous System Tumors; Brain Tumors

Summary: the purpose of the study was to determine if treating a limited volume of normal tissue surrounding the tumor or tumor bed using conformal radiation therapy would achieve similar rates of disease control compared to standard radiation therapy. the study was also conducted to examine the effect of irradiation on neurological, endocrine and cognitive function.

radiation therapy is commonly used to treat a variety of brain tumors in children including ependymoma, craniopharyngioma and low- and high-grade glioma. the ability of the therapy to control brain tumors in children is known to depend on the tumor type, extent of resection and other clinical factors. children who received radiation therapy on this study were evaluated for treatment failure at 12 months. in addition to the primary objective, the study was designed to explore the association between radiation dose and volume and a variety of neurological, endocrine and cognitive deficits up to 5 years after treatment.

Eligibility criteria:
inclusion criteria: * age at time of irradiation is greater than or equal to 8 months and less than or equal to 25 years * histologically diagnosed craniopharyngioma, ependymoma, low-grade astrocytoma or high-grade glioma and radiographically diagnosed selected patients with craniopharyngioma and low-grade glioma. * adequate performance status, participant has an ecog (performance status score) of 0-2(0=normal activity; 1=symptoms but ambulatory; 2=bedridden \<50% of time) * histologic type that requires only focal irradiation. * no prior fractionated external beam irradiation * informed consent signed by patient, parent, or guardian.

Keywords: brain neoplasm brain cancer neoplasm intracranial
pazopanib for metastatic alveolar soft part sarcoma

Conditions: Metastatic Alveolar Soft Part Sarcoma

Summary: alveolar soft part sarcoma (asps), a rare subset of sts (\<1%) harbors t(x;17)(p11;q25) translocation and produces resultant aspl-tfe3 fusion protein. due to its nature of high expression of angiogenic factors, sunitinib and cediranib produced overall response rates of 55% and 43%, respectively. however, the efficacy of pazopanib is unknown in metastatic asps.

pazopanib, a multi-targeted anti-angiogenesis inhibitor significantly prolonged progression-free survival (pfs) in patients with metastatic soft-tissue sarcoma (sts) after failure to anthracycline-based regimen (pazopanib vs placebo, 4.6 vs 1.6 months, hr=0.31, 95% ci 0.24-0.40; p \< .0001). regarding sunitinib (continuous daily dose of 37.5mg), after a median duration of 10 months, median os and pfs were 19 months and 17 months, respectively in a small retrospective study (asps, n=9). with regard to cediranib, 6-month pfs was over 60%. in addition, randomized phase ii trial of sunitinib vs cediranib with cross-over at disease progression was recently initiated (nct01391962). however, the efficacy of pazopanib is unknown in metastatic asps.

Eligibility criteria:
key inclusion criteria: * histologically confirmed diagnosis of alveolar soft part sarcoma harboring tfe3 fusion at stage iv or at relapse * age ≥ 18 years * eastern cooperative oncology group (ecog) performance status of 0-2 * measurable lesion defined by recist v1.1 * chemo-naïve or prior chemotherapies * adequate organ function exclusion criteria: * prior malignancies * active cns disease * high-risk for gastrointestinal bleeding * significant cardiovascular disease * uncontrolled hypertension * bleeding diathesis

Keywords: pazopanib alveolar soft part sarcoma
developing a simple recognition system of acromegaly

Conditions: Acromegaly

Summary: we will compare the features of 3d stereophotography of acromegaly patients with that of healthy people. we hope to develop a computerized model to help screening acromegaly patients for early detection and treatment.

background: acromegaly is a slowly progressive disease caused by growth hormone (gh) excess. the estimated prevalence of the disease is 40 cases/1000000 population with 3-4 new cases/1000000 population per year. most patients have classic manifestations due to acral and soft tissue change, including thickening of the calvarium, increased size of frontal sinus, enlargement of the nose, prognathism, and widely spaced teeth. the hands and feet are large, thickened and bulky. acromegaly was also associated with many comorbidities including cardiovascular complications (acromegalic cardiomyopathy and arterial hypertension), respiratory complications (sleep apnea), metabolic complication (impaired glucose tolerance, diabetes mellitus), joint and bone complications (carpal-tunnel syndrome, osteoarthritis).3 the outcome of growth hormone level suppression after transsphenoidal surgery is far better for microadenomas (80-90%) than for macroadenomas (less than 50%). furthermore, higher growth hormone level at diagnosis was related to poor prognosis. an early detection of acromegaly with early intervention was desirable. however, due to the slowly progression of the disease, times from symptom onset to diagnosis were 5.2 to 5.9 year4. current method to diagnose patients with acromegaly was to check serum gh and insulin-like growth factor 1 (igf-1). however, tests for growth hormone and igf-1 are currently unavailable in most hospitals in taiwan and were expensive. we want to find a better screening tool for acromegaly with less expensive and high efficacy. due to specific facial appearance of acromegaly, there were studies to recognize acromegaly by computer program1,2,3. they tried to develop computer programs to separate facial photographs of patient with acromegaly and normal subjects. the accuracy could reach 71.9% to 86%. due to enlarged hand with increased soft tissue in patients with acromegaly, we also want to compare the difference of face, hand and feet morphology and face, hand and feet x ray of acromegaly patients with those of normal population. we hope to set a computer model to early detect acromegaly patients in chinese people.

Eligibility criteria:
inclusion criteria: * age 20-80 years old, acromegaly patients or healthy adults exclusion criteria: * pregnancy. age less than 20 years old or older than 80 years old
evaluation of the vot among tuberculosis patients from lambaréné

Conditions: Tuberculosis

Summary: this pilot study aimed to assess the feasibility of using an instant messenger to monitor drug intake in tuberculosis patients and to assess cash incentive to improve adherence to drug intake

at the initial visit, the inclusion criteria are cross-checked, the subject is informed of the study procedures, and an informed consent form is signed by subjects willing to participate. for the participants from the intervention group, the research team will provide a smartphone with the whatsapp application to each participant. at the initial visit, the research team will explain to the participants how to use the phone and the instant messenger application for the study. briefly, the subject is filmed while taking the drug. this can be via a "selfie" or by a family member. the video is then sent to the study phone contact. once the video is received by an investigator, a message will be sent back to the participant's mobile phone acknowledging receipt of the video. an investigator trained on the dot protocol, will review the video clips to assess if the drug was taken correctly or not. a daily log is filled in to keep track of drug intake for each participant. participants from both the control and intervention group are seen once per month in person for follow-ups and getting new drugs. at these time points information on drug intake is gathered.

Eligibility criteria:
inclusion criteria: older than 18 years * signed informed consent form * living in an area with mobile phone coverage * have at least 3 months of treatment remaining exclusion criteria: • not being able to use a smartphone and unlikely to learn how to
laparoscopic versus open resection of cancer stomach

Conditions: Gastric Cancer

Summary: the aim of surgical procedures for resection of cancer stomach is to resection of the tumor mass with safety margin and its drainage lymph nodes (lymphadenectomy). there are two main types of techniques (open \& laparoscopic) many studies were done comparing these two techniques showed that laparoscopic resection is superior in early postoperative recovery (less pain ,less bleeding and shorter hospital stay) but less radical than open resection (less safety margin \& less lymphadenectomy) but because of the ongoing advances on laparoscopic surgery these results needs more and more revision. so the investigators conduct this randomized controlled trial aiming at comparing open and laparoscopic resection of cancer stomach to choose the best surgical procedure for resection of cancer stomach.

the surgical procedure for resection of cancer stomach aiming at resection of the tumor mass with safety margin and its drainage lymph nodes (lymphadenectomy). # tumor resection; will be done by one of the following techniques: 1. laparoscopic gastrectomy (totally laparoscopic, laparoscopy-assisted, and hand-assisted) types of gastrectomy (according to site of tumour) 2. open gastrectomy (according to the site of tumor). # lymphadenectomy; will be done according to japanese gastric cancer association guidelines for optimal lymph node dissection levels for early gastric cancer (1): * d1+alpha -(perigastric lymph node dissection) for mucosal cancer, for which emr is not indicated and for histologically differentiated submucosal cancer of \< 1.5 cm in diameter; * d1+ beta for preoperatively diagnosed submucosal cancer without lymph node metastasis (n0), for which d1+ alpha is not indicated, and for early cancer \< 2.0 cm in diameter with only perigastric lymph node metastasis (n1); * d2 for early cancer \> 2.0 cm in diameter. follow up: all patients will be followed up clinically for the outcomes for each surgical technique.

Eligibility criteria:
inclusion criteria: * all patients with primary carcinoma of the stomach, where the tumor is considered surgically resectable (t1-3, n0-1, m0). exclusion criteria: * pregnancy. * infiltration to the( pancreas ,liver ,colon or vital vascular structure). * metastasis to the (liver, lung, brain, paraaortic ln involvement). * peritoneal deposit. * surgically unfit patient.
national education programme for patients with chronic adrenal insufficiency

Conditions: Adrenal Insufficiency

Summary: even under established replacement therapy, patients with adrenal insufficiency still suffer from impaired quality of life and experience adrenal crises. patient education is regarded as important preventive measure. in this study a german-wide standardized education programme will be evaluated.

design aspects: in a prospective trial the efficiency of a german-wide education programme in patients with chronic adrenal insufficiency will be evaluated by using a questionnaire before and after training. patients: patients will be recruited out of the patient population of the participating nine medical centers. to achieve a anticipated number of 450 patients, each center will include al least 50 patients with chronic adrenal insufficiency under established replacement therapy . trial flow: during sessions of 90 minutes duration, patients and relatives are educated in basic knowledge on adrenal insufficiency including the correct behaviour in emergency settings. participants are provided with emergency cards and sets and are trained in self-injection of glucocorticoids. to evaluate the standardized education programme, patients complete three questionnaires (before, shortly after and 6-9 months after the training) at nine endocrine centres. all centres had been certified by the german endocrine society for the education programme. questionnaires assess general knowledge on adrenal insufficiency and document the influence on patients' feeling of security. statistical analysis: documentation and analysis will be performed at the department of medicine i, endocrine and diabetes unit, university of würzburg, germany. data will be documented after pseudonymisation in a data base. data analysis is mainly descriptive. stopping rules: participation of patients is fully voluntarily. patients are able to stop participation in the study at any point in time. in addition, patients might claim the elimination of all data material at any point in time.

Eligibility criteria:
inclusion criteria: * age \> 18 years * patient's written informed consent * ability to comply with the protocol procedures * patients with primary or secondary adrenal insufficiency under established stable replacement therapy

Keywords: adrenal crisis education programme
long term nitric oxide bioavailability on vascular health in chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: chronic obstructive pulmonary disease (copd) affects up to 14 million people and is among the top five leading causes of death worldwide. although copd is a disease of the lungs, recent evidence indicates that copd is associated with multiple systemic consequences including vascular endothelial dysfunction. recently, it has been suggested that more patients with copd die from cardiovascular disease and coronary heart disease than of direct pulmonary complications. examination of the mechanisms that contribute to a reduction nitric oxide (no) bioavailability resulting in vascular endothelial dysfunction in patients with copd are important as endothelial dysfunction has been indicated to be an independent predictor of future atherosclerotic cardiovascular disease and events.

researchers have found a link between chronic obstructive pulmonary disease (copd) and heart disease; however, a link is all they have found. in a previously funded grant, using a double blind, randomized experimental design, the investigators explored the effect of an acute dose of kuvan or an antioxidant cocktail (1000mg of vitamin c, 600iu of vitamin e, and 600mg alpha-lipoic acid) on vascular health in patients with copd. consequently, the investigators found in separate experiments, that a single dose of both antioxidants and kuvan transiently improves vascular health in patients with copd. the current project is an attempt to expand on the investigator's previous findings and explore the effects of sub-chronic use of antioxidants and kuvan on sustaining the improvements in vascular health in copd.

Eligibility criteria:
inclusion criteria: * patients with medically diagnosed copd * apparently healthy controls exclusion criteria: * fev1/fvc \>0.7 (normal lung function in patients only) * clinical diagnosis of heart disease or diabetes * vasoactive medications (i.e. nitrates, beta-blockers, viagra etc.) * uncontrolled high blood pressure * high blood pressure in your lungs * thyroid problems * fluid in the lungs * sleep apnea * anemia * raynaud's phenomenon * gi bleeding * gangrene of the digits * history of low platelets or coagulopathies * phenylketonuria (pku) * any allergy to kuvan

Keywords: flow-mediated dilation kuvan antioxidant fev1
a retrospective study on the relationship between donor leukocyte telomere length and prognosis of acute leukemia patients treated with allogeneic hematopoietic stem cell transplantation

Conditions: Acute Leukemia

Summary: this post hoc analysis included patients with acute leukemia who underwent allo-hsct at the first affiliated hospital of zhejiang university school of medicine and ruijin hospital shanghai jiaotong university school of medicine. patients and their donors were assessed for eligibility to join this study. the inclusion criteria were: (1) age ≥ 5 years; (2) diagnosis of acute leukemia including acute myeloid leukemia, acute lymphocytic leukemia, and mixed phenotype acute leukemia; (3) patients attained complete remission (cr) and achieved full engraftment with 100% donor chimerism following allo-hsct; (4) telomere testing was conducted on peripheral leukocytes of donors before granulocyte colony-stimulating factor (g-csf) mobilization, and the results were obtained. written informed consent was obtained from all included patients and their donors, and the study was conducted in compliance with the declaration of helsinki. ethical approval was approved by the ethics review committee of the first affiliated hospital of zhejiang university school of medicine.


Eligibility criteria:
inclusion criteria: * age ≥ 5 years * first allo-hsct from matched related, unrelated, or haploidentical donors * achievement of complete remission after allo-hsct * donor blood sample collection before granulocyte colony-stimulating factor mobilization exclusion criteria * non-acute leukemia diagnoses, including acute myeloid leukemia, acute lymphocytic leukemia, and mixed phenotype acute leukemia * failure to achieve engraftment with full donor chimerism after allo-hsct * inability to extract dna for telomere length analysis.
prognostic factors of covid19

Conditions: SARS-CoV-2

Summary: covid-19 is an emerging disease, for which no specific treatment options are currently available. since the end of february 2020, and due to a sars-cov-2 superspreading event (religious meeting), the strasbourg university hospital (hus) had faced a sudden increase of the number of covid-19-positive patients in serious condition requiring hospitalization. at the same time, many people develop only mild or moderate symptoms. to date, the prognostic factors for the course of sars-cov-2 infection are unknown. the primary purpose of the "covid-hus" protocol is to investigate viral and host-related factors to understand the pathophysiology of covid infection and to open the way for new diagnostic, prognostic and therapeutic strategies against sars cov-2 . the secondary objectives are * monitoring of viral replication of sars-cov-2 in the blood and respiratory tract in infected patients * monitoring of the humoral and cellular response directed against sars-cov-2 * identification of factors leading to significant and / or prolonged viral replication of sars-cov-2 in the blood or respiratory samples * evaluation of the benefit of possible treatments implemented following the diagnosis of sars-cov-2 infection * exploration of the b and t immune repertoire sequences targeting sars-cov-2 in infected patients * typing of the hla system in infected patients


Eligibility criteria:
inclusion criteria: * adult and pediatric with suspicion or a confirmed sars-cov-2 infection * patient who has signed a non-opposition form (or a form signed by a family member or a support person if the seriousness of the patient's condition and the emergency situation do not allow it) or who has given his oral agreement to the doctor exclusion criteria: * patient's explicit refusal to participate * subject deprived of liberty or subject to the protection of justice * subject under guardianship or trusteeship

Keywords: sars-cov-2 covid-19 prognostic factors genetic factors t and b cell immune response