Kornimate/medical-research-clean huggingface dataset:
light therapy on major depression disorder

Conditions: Depressive Disorder

Summary: background: major depression disorder is a common psychological disease. it is the second-ranked cause of disability worldwide. the pathophysiology is not yet understood. the main theory is monoaminergic theory based on the effect of monoaminergic drugs. current treatment includes psychotherapy, medication and electroconvulsive therapy. the onset of action for antidepressant is often slow, therefore strategies to improve the outcome are important. bright light therapy has been found to be effective in reducing the severity of depression not only in seasonal affective disorder but also in other affective disorder. previous meta-analyses of light therapy for non-seasonal major depression, however, has yielded conflicting evidence for efficacy. purpose: 1. to investigate possible imaging biomarkers of major depression disorder 2. to evaluate the effect of light therapy on depression materials and methods: this prospective study will recruit 100 patients, randomized into 2 study groups: (1) antidepressant plus treatment light, and (2) antidepressant plus placebo light. all patients will accept a thorough psychological evaluation (including hamilton depression rating scale, montgomery-asberg depression rating scale, clinical global impression-severity and patient health questionnaire-9 items) at baseline and at the 1st, 2nd, 4th, 8th week during the 8-week experiment intervention, by a blind assessor. morningness- eveningness questionnaire-self-assessment version (meq-sa) was only evaluated at baseline. adverse events were evaluated at baseline, 2nd,4th,8th weeks. mri study will be arranged at baseline and in 4-week experiment. predicted results and influence: 1. to evaluate the additional effect of the treatment light on depression disorder 2. to compare the difference of functional magnetic resonance imaging(fmri), structural mri among the two groups and between the patients with and without treatment effect in order to detect imaging biomarkers.


Eligibility criteria:
inclusion criteria: 1. fulfill diagnosis of major depression disorder based on diagnostic and statistical manual of mental disorders(dsm-v) for at least 6 weeks and under medication treatment for at least 4 weeks. 2. at least 20 years old 3. hamilton depression rating scale(hamd-17) \>= 13 4. no medication change for at least 4 weeks and no medication change will be considered in the next 8 weeks. 5. agree to participate in this study and sign the permit. exclusion criteria: 1. seasonal depression disorder 2. other psychological or neurological disorder 3. drug or alcohol abuse within 30 days 4. visual problem 5. light-induced seizure or migraine 6. contraindication for mri study 7. severe illness and might be admitted in the near future 8. might have a long trip in the near future
iadapt to support strategy training after stroke

Conditions: Stroke; Adherence, Patient; Strategy Training

Summary: adherence to rehabilitation interventions is associated with functional outcomes (e.g. independence in daily activities, return of motor function) after stroke. low adherence to rehabilitation home programs is common after stroke. interventions delivered via mobile health applications demonstrated positive effects on adherence to health behaviors (e.g. medication routines, smoking cessation). the investigators developed the iadapt mobile application to support adherence to strategy training. strategy training is an iterative rehabilitation intervention the promotes goal setting, planning, and self-monitoring after stroke. this study examines the effects of the iadapt mobile health application relative to a workbook on adherence to strategy training after stroke.


Eligibility criteria:
inclusion criteria: -diagnosis of stroke exclusion criteria: * prior exposure to strategy training * vision impairment that impairs ability to read device screen or worksheet * poor self-awareness (score of ≥2 on self awareness of deficits inventory item #1 or #2 * current major depressive, bipolar, or psychotic disorder (patient health questionnaire-9, prime-md) * current alcohol or drug abuse (mini international neuropsychiatric interview) * severe aphasia (score ≤1 on boston diagnostic aphasia examination) * current diagnosis of dementia, neurodegenerative disease, or cancer * anticipated discharge to a skilled nursing facility

Keywords: rehabilitation disability mobile health technology
fetal thymus volume of dichorionic diamniotic twin

Conditions: Twin Pregnancy, Antepartum Condition or Complication; Fetal Thymus Volume; Preterm Birth

Summary: in some studies of fetal thymus volume, fetal stress factors; infection, preterm premature premature rupture of membranes, preeclampsia, preterm delivery risk. generally, there is a direct correlation between fetal growth and thymus volume and it was observed that thymus volume decreased in pregnancies accompanied by fetal stress factors.the aim of this study was to measure fetal thymus volume in second trimester twin pregnancies and to investigate whether there is a statistically significant correlation between preterm birth risk pregnancies.


Eligibility criteria:
inclusion criteria: * dichorionic di amniotic twin pregnancies between 18 weeks and 23 days 6 days exclusion criteria: * single pregnancy, * first and third trimester pregnant women, * urinary tract infection, immune system diseases * fetuses with intrauterine genetic and / or multiple morphological diseases
cardiovascular reactivity to physical stress

Conditions: Blood Pressure; Stress, Physiological

Summary: it is well-accepted that an exaggerated blood pressure (bp) response to physical stress has a prognostic value, indicating a higher cardiovascular risk (e.g., sudden cardiac death, myocardial infarction, future hypertension, and left ventricular hypertrophy). however, there is a limited understanding of the underlying mechanisms and therapuetic strategies modulating this response. therefore, this pilot project aims to explore whether one session of low-volume high-intensity interval training (low-volume hiit) or combined intermittent heat and cold bath (sauna+cold bath) can decrease bp responses to physical stress. furthermore, the secondary goal is to investigate whether one brief session learning about positive stress expectations magnifies the decrease in bp following low-volume hiit and sauna+ cold bath.


Eligibility criteria:
inclusion criteria: * male or female between 18 to 50 years * non-smoker. * non-obese (\<30 kg/m2). * able to walk on a treadmill and cycle on a stationary bike without problems. * no or little (frequency \< 2 times per month) experience swimming with sauna and cold water. * proficient in norwegian and able to provide informed consent. exclusion criteria: * current or previous regular smoker * addictions to alcohol or illegal drugs * diagnosed with cardiovascular, respiratory, metabolic, or autoimmune diseases * taking prescription medication with known cardiovascular effects * judgment by a medical provider that exercise, heat therapy, or hydrotherapy poses an undue burden or risk. * cognitive or psychiatric impairment * lack of proficiency in norwegian language oral or writing skills that will hamper the ability to participate in the interventions and fill out questionnaires.

Keywords: cardiovascular reactivity neural control of blood pressure metaboreflex cold pressor response
davita assessment of nutritional supplement effects (danse)

Conditions: Malnutrition

Summary: this is a phase iv randomized controlled study assessing the effectiveness of a commercially available nutritional supplement on malnourished prevalent hemodialysis patients. patients will be randomized to either receive one can of nepro with carb steady at each dialysis treatment for 6 months or to receive the standard of care counseling for malnutrition. the primary hypothesis is that hypoalbuminemic maintenance hemodialysis patients will demonstrate an improvement in albumin levels with oral nutritional supplement provided in-center thrice weekly in addition to standard of care as compared to malnourished maintenance hemodialysis patients provided standard of care alone.


Eligibility criteria:
inclusion criteria: * patient is at least 18 years of age * patient has been on hemodialysis \>6 months at the time of study entry * patient dialyzes three times a week * patient agrees to try ons for the 6 month study period. * patient has demonstrated an albumin \<3.5 g/dl on last available lab drawn in dialysis facility * patient is adequately dialyzed with a kt/v \> 1.4 at the most recent lab draw * patient is capable of reading and comprehending informed consent form and provides written informed consent exclusion criteria: * peritoneal dialysis * dysphagia * aspiration risk * difficulty swallowing * history of symptomatic intolerance to food or liquid consumption during dialysis treatments * terminal illnesses with life expectancy \<6 months, e.g. stage iv cancer or full blown aids * concurrent appetite stimulants * use of idpn in last 3 months * inability to follow and to comply with the instructions and guidelines * severe liver disease defined as most recent sgot \> 78 * active malignancy (other than skin) * major surgery within previous 6 months or anticipated during the 90-day study period * females who are pregnant or are breast-feeding * considered clinically unstable by the treating nephrologists * noncompliance with dialysis treatments ( missed \> 2 treatments in prior month due to noncompliance) * extended or frequent hospitalizations defined as hospitalization of longer than 15 days with discharge within the last 30 days or greater than 3 admissions within the last 30 days * regular supplement use defined as consumption of \> 7 servings of a commercially available kcal/ protein supplement in the prior month * any clinically significant medical disease or condition that, in the investigator's opinion, may interfere with protocol adherence or a patient's ability to give informed consent

Keywords: nutritional supplement malnutrition hemodialysis nepro with carb steady
a study of si-6603 in patients with lumbar disc herniation

Conditions: Intervertebral Disc Disease; Lumbar Disc Disease

Summary: the purpose of this study is to evaluate the safety and efficacy of si-6603(condoliase) in patients with lumbar disc herniation.


Eligibility criteria:
inclusion criteria: * patients with lumbar disc herniation (l1-l2, l2-l3, l3-l4, l4-l5 or l5-s1) as assessed by mri and clinical symptoms corresponding to position of the impaired nerve root. * patients assessed as positive in the femoral nerve stretching (fns) test for l1-l2, l2-l3, or l3-l4 and straight leg raising (slr) test. * patients with sciatica in either leg. * patients with no improvement from conservative treatment exclusion criteria: * patients who have 2 or more lumbar disc herniations as assessed by mri. * patients in whom a rupture into the posterior longitudinal ligament is identified by mri. * patients who have undergone lumbar operation, or lumbar percutaneous nucleotomy or lumbar intradiscal therapies
the influence of antenatal classes on pregnancy, birth and parenthood

Conditions: Pregnancy; Parturition

Summary: 1. to study the influence of antenatal classes for first time parents and their effect ob pregnancy, birth and parenthood. 2. randomized into two groups (a. 3 courses in midpregnancy and b. no courses) 3. data on pregnancy, birth and parenthood are collected from register and questionaire

data collected contain register data and data from questionnaire, which also contains psychometric tests

Eligibility criteria:
inclusion criteria: pregnant over 18 years of age singleton exclusion criteria:

Keywords: pregnancy parturition depression randomized antenatal classes
super-resolution of brain magnetic resonance images in deep brain stimulation for parkinson's disease

Conditions: Parkinson Disease; Parkinson

Summary: the goal of this study is to increase magnetic resonance image quality in patients suffering from parkinson's disease. the main question it aims to answer is: can super-resolution improve clinical magnetic resonance image quality to benefit deep brain stimulation for parkinson's disease? participants will receive an additional high-quality mri scan.

rationale: better targeting of the subthalamic nucleus (stn) improves the outcome of deep brain stimulation (dbs) for parkinson's disease. yet, the accuracy of delineating the stn, and therefore the targeting, is limited by the spatial resolution of the magnetic resonance (mr) imaging. the current study aims to acquire a high resolution (hr) mr dataset, tailored to visualise the stn, to train a super-resolution model to predict hr mr images based on lower resolution mr input. this model will aid delineating the stn and improve segmentation and targeting. objective: to develop a deep learned super-resolution model that predicts high-resolution mr images with a peak signal-to-noise ratio of 37 decibel or higher. study design: prospective observational study. study population: twenty parkinson's patients considered eligible for dbs surgery at radboud university medical centre will be included. main study parameters/endpoints: peak signal-to-noise ratio measured in decibels.

Eligibility criteria:
inclusion criteria: * patients eligible for bilateral stn-dbs-surgery for parkinson's disease. * signed informed consent exclusion criteria: * any intracranial abnormality that is not in line with parkinson's disease progression * previous intracranial surgery * any significant medical condition that is likely to interfere with study procedures. * pregnancy at the time of enrollment. * participation in any other clinical trial (e.g. drug, device, or biologics) that interferes with this study.

Keywords: magnetic resonance imaging mri super resolution
image fusion system for 3d preoperative planning in the osteosynthesis and osteotomy

Conditions: Fractures, Bone; Fracture Malunion, Bone

Summary: utility of image fusion system for the fracture and fracture malunion management will be evaluated.

the fracture and malunion patients need osteosynthesis or osteotomy will be recruited. image fusion group utilizes 3d preoperative planning and image fusion system. control group utilizes only 3d preoperative planning. the age, sex, and fracture types will be matched between groups. in both groups, 3d preoperative planning will be performed in order to determine reduction, placement and choices of implants. in the image fusion group, the outline of planned image will be displayed on the monitor overlapping with fluoroscopy image during surgery. reductions, implant choices/positions, and clinical outcomes will be evaluated.

Eligibility criteria:
inclusion criteria: * fracture paitents need osteosynthesis exclusion criteria: * fracture patients under 18 years old
observational safety study of rituximab in patients diagnosed with rheumatoid arthritis (ra) who did not respond adequately to tnf-alpha blocker

Conditions: Rheumatoid Arthritis

Summary: this multi-center, observational, retrospective-prospective cohort study will investigate the safety of rituximab (mabthera) by collecting data from daily clinical practice on the use of rituximab and its relative clinical impact, particularly with regard to adverse events. data from each patient will be collected over 24 months after enrolment in the study. target sample size is up to 325 patients.


Eligibility criteria:
inclusion criteria: * patients diagnosed with ra who did not respond adequately to anti-tnf-alpha and who started rituximab (rtx) treatment in the 12 months before site initiation and were still under treatment when enrollment starts exclusion criteria: * patients with serious infections
a study of doravirine/islatravir (dor/isl, mk-8591a) for the treatment of human immunodeficiency virus 1 (hiv-1) infection in participants who previously received dor/isl (mk-8591a-054)

Conditions: HIV Infection

Summary: the purpose of this study is to evaluate the safety and tolerability of dor/isl in adult participants with hiv-1 who had been previously treated with dor/isl in earlier clinical studies. there are no formal hypotheses to be tested in this study.


Eligibility criteria:
inclusion criteria: * is currently receiving doravirine/islatravir (dor/isl) adult fixed dose combination (fdc) tablet in merck sharp \& dohme (msd)-sponsored clinical studies (mk-8591a-017, -018, -020, and -033 \[except for heavily treatment-experienced (hte) participants\]). exclusion criteria: * has confirmed hiv-1 rna ≥200 copies/ml in msd dor/isl (100 mg/0.75 mg) mk-8591a-017 /-018 /-020, or at screening for participants entering from dor/isl (100 mg/0.75 mg) mk-8591a-033. * has confirmatory laboratory findings for cluster of differentiation 4+ (cd4+) t-cell counts or lymphocyte counts in the prior dor/isl study that meet criteria for discontinuation of dor/isl. * is a hte participant receiving treatment in mk-8591a-019 or -033.
hypertension in patients hospitalized with covid-19

Conditions: COVID-19; Hypertension

Summary: some studies have shown that the main pathogenesis of patients with covid19 is related to ace2 receptor. lung is one of the main organs, and there are many ace2 receptors in cardiovascular system. acei / arb is the main target of antihypertensive drugs. previous reports suggested that there were large number of patients with covid19 also suffered from hypertension, suggesting that patients with hypertension may be the susceptible to covid19. therefore, we try to follow up the patients admitted to hankou hospital to explore the impact of hypertension and hypertension treatment on the severity and prognosis of patients with covid19, so as to provide new methods for the treatment of patients with covid19 in the future.

in december, 2019, a cluster of severe pneumonia cases of unknown cause emerged in wuhan, china, with clinical presentations greatly resembling viral pneumonia1. deep sequencing analysis from lower respiratory tract samples indicated a novel coronavirus, which was named 2019 novel coronavirus (2019-ncov, then named covid-19). up to mar 16, 2020, the total number of patients had risen sharply to 153,546 confirmed cases worldwide (http://2019ncov.chinacdc.cn/2019-ncov/global.html). the data extracted from 1099 patients with laboratory-confirmed covid-19 in china from january 29, 2020 showed that hypertension is the most common coexisting illness of covid-19 patients, ranging from 13.4% in nonsevere patient vs. 23.4% in severe patients, and the total incidence is as high as 15%2. interestingly, ace2 is involved in the pathogenesis of both hypertension and sars-cov-2 pneumonia. the above reasons prompted us to speculate that the organs attacked by sars-cov-2 might not only be lungs, but also include other ace2 expression organs, especially cardiovascular system. in addition, patients with comorbid hypertension, especially those with long-term oral acei/arb medication for hypertension, might have different susceptibility and severity levels of pneumonia upon sars-cov-2 attack. therefore, we investigated and compared the demographic characteristics, coexisting disease, severity of pneumonia, and the effect of antihypertensive drugs (acei/arb versus non-acei/arb) in patients with covid-19 coexisting hypertension, thereby, hopefully, to reduce the mortality and morbidity associated with hypertension in patients with covid-19.

Eligibility criteria:
inclusion criteria: * covid-19 pneumonia patients diagnosed by who criteria exclusion criteria: * patients who were younger than 18 years. * patients whose entire stay lasted for less than 48 hours.

Keywords: covid-19 hypertension ace2
clinical research on a novel deep-learning based system in mediastinal endoscopic ultrasound scanning

Conditions: Mediastinum Disease

Summary: the goal of this clinical trial is to develop and verify the auxiliary role of the artificial intelligence system in mediastinal ultrasound endoscopic scanning. the main questions it aims to answer are as follows: 1.the comparison of the image recognition accuracy between the artificial intelligence system and the ultrasound endoscopist; 2. whether the artificial intelligence system can improve the integrity and efficiency of the mediastinum scanning for the ultrasound endoscopist. participants will undergo mediastinal eus with or without the assistance of the artificial intelligence system.

in this study, a total of 200 cases of mediastinal endoscopic ultrasound scanning videos will be collected. first of all, an artificial intelligence system based on deep learning for the navigation and quality control of mediastinal endoscopic ultrasonography will be established. secondly, the artificial intelligence system will be used to identify the site and anatomical structure of the mediastinal ultrasound endoscope, and the results of the artificial intelligence system's station recognition will be compared with the results of the endoscopist's station recognition. finally, the completeness of standard sites and scanning time of endoscopic-assisted and non-assisted ai systems were compared.

Eligibility criteria:
inclusion criteria: * 1. age ≥18 years old, \<80 years old 2.patients who need endoscopic ultrasonography; 3. agree to participate in this study and sign the informed consent form. exclusion criteria: * subjects who meet any of the following criteria cannot be selected for this trial: first. the patient's physical condition does not meet the requirements of conventional endoscopic ultrasonography: 1. poor physical condition, including hemoglobin ≤8.0g/dl, severe cardiopulmonary insufficiency, etc. 2. anesthesia assessment failed 3. pregnancy or breastfeeding 4. in the acute stage of chemical and corrosive injury, it is very easy to cause perforation 5. recent acute coronary syndrome or clinically unstable ischemic heart attack 6. heart disease patients with right-to-left shunt, patients with severe pulmonary hypertension (pulmonary artery pressure\> 90mmhg),patients with uncontrolled systemic hypertension and patients with adult respiratory distress syndrome. second. disagree to participate in this study. third. there are other problems that do not meet the requirements of this research or that affect the results of the research: 1. mediastinal lesions have previously undergone surgery or radiotherapy and chemotherapy; 2. mental illness, drug addiction, inability to express themselves or other diseases that may affect follow-up.

Keywords: eus ai quality control training