Kornimate/medical-research-clean huggingface dataset:
pay-it-forward rct for gonorrhea and chlamydia testing

Conditions: Gonorrhea Male; Chlamydia;M

Summary: this is a randomized controlled trial which will evaluate dual gonorrhea/chlamydia test uptake and other outcomes in men who have sex with men (msm) in three trial arms - 1) a pay-it-forward testing arm, 2) a pay-what-you-want testing arm, and 3) standard of care arm.

at both of the program sites, msm partaking in hiv and syphilis testing will be offered dual gonorrhea/chlamydia testing. first, all men will be provided a brief (5 minute) introduction to gonorrhea and chlamydia testing using a pamphlet. program organizers will then explain the pay-it-forward program to each man separately. briefly, men will be told that the hospital list price of gonorrhea and chlamydia testing was 150 rmb ($24 usd), but previous men attending the clinic had donated money to cover the cost of his test. thus, each man could receive a free gonorrhea and chlamydia test, then decide whether to donate money (pay-it-forward) for future men to receive the same option. men will be assured that donating is completely optional and advised to pay any amount that is feasible for them. each man's gonorrhea and chlamydia test fees will be covered by a combination of the initial funding pool from the program organizers and the donations from previous participants. men will also be shown a postcard with a message written by a previous pay-it-forward contributor. messages will contain information encouraging men to be tested/slogans to promote sexual health and testing (i.e. taking ownership of their health). they will be told that they could also write a postcard message for a future participant. men will then decide whether or not to receive combined urine gonorrhea/chlamydia testing. program organizers will inform participants of their test results via wechat. patients with positive test results will be counseled and directed to the wechat page of designated hospitals where they could make an appointment to receive treatment and follow-up.

Eligibility criteria:
inclusion criteria: * born biologically male * age 16 years or older * report previous anal sex with another man * willing to provide mobile phone number for results notification exclusion criteria: * tested for both gonorrhoea and chlamydia in the past 12 months with no high-risk sexual behavior following testing * previous participation in pay-it-forward program
manual versus sonic-powered toothbrushing for plaque reduction in patients with peri-implant mucositis

Conditions: Toothbrushing; Periimplant Diseases

Summary: aim: to compare the effect of manual and sonic-powered toothbrushing on biofilm control in patients with peri-implant mucositis. materials and methods: the study was completed with a total of 41 patients, 21 in the sonic tooth brushing group and 20 in the manual tooth brushing group. the patients' baseline, 3rd-month, 6th-month and 9th-month periodontal examination data (modified gingival i̇ndex (mgi), modified plaque index (mpi), bleeding on the probing index (bop), pocket depth (pd), gingival recession (gr) and gingival biotype (gb)) were analyzed.


Eligibility criteria:
inclusion criteria: 1. bleeding on probing around the implant 2. no bone loss around the implant in the radiograph 3. having adequate keratinized gingiva around the implant 4. the presence of an implant prosthesis that was installed at least three months previously 5. no systemic disease 6. no smoke 7. no use of antibiotic medications within the previous three months exclusion criteria: 1. patients with missing data and who do not allow data use 2. smoker 3. data from pregnant and lactating patients 4. pocket depth around the implant is ≥ 5 5. patients with peri-implantitis (bone loss around the implant) 6. patients with insufficient attached gingiva around the implant

Keywords: biofilm dental i̇mplant peri-implant mucositis toothbrushing
pathophysiology of orthostatic intolerance

Conditions: Tachycardia; Postural Orthostatic Tachycardia Syndrome

Summary: the purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies. the syndrome is of undetermined etiology, but the syndrome causes impairment of a number of young adults, females more than males, with symptoms of tachycardia, fatigue, lightheadedness, palpitations, blurred vision, chest discomfort, difficulty concentrating, and dizziness with the upright posture. it is believed that many different pathophysiological processes can give rise to this disorder.


Eligibility criteria:
inclusion criteria: * orthostatic intolerance exclusion criteria: * inability or unwillingness to give informed consent

Keywords: heart rate blood pressure blood volume sympathetic nervous system orthostatic tachycardia orthostatic intolerance pots
use of letrozole pretreatment with misoprostol for first-trimester medical abortion

Conditions: Complete Miscarriage

Summary: the purpose of this study is to compare the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.

primary outcome: incidence of complete miscarriage (complete expulsion of the products of conception with no need for surgical intervention within one week from the first dose of misoprostol) secondary outcome: need for surgical evacuation of the products of conception * incomplete expulsion of the products of conception (incomplete miscarriage). * considerable bleeding necessitating immediate surgical evacuation. maternal morbidity * major side effects (sepsis, considerable vaginal bleeding leading to hemodynamic instability or necessitating blood transfusion) * minor side effects (fever, rigors, nausea, vomiting) patient's compliance and adherence to treatment hemoglobin and hematocrit deficit

Eligibility criteria:
inclusion criteria: * maternal age more than 18 years old (age of legal consent). * gestational age less than 13 weeks. * hemoglobin \>10 g/dl. * bmi between 25 kg/m2 and 35 kg/m2. * missed abortion. * living fetus with multiple congenital malformations incompatible with life. exclusion criteria: * maternal age less than 18 years old. * gestational age more than 12 weeks. * hemoglobin \<10 g/dl. * anencephaly. * fibroid uterus. * bmi less than 25kg/m2 and more than 35kg/m2. * coagulopathy. * history or evidence of adrenal pathology. * previous attempts for induction of abortion in the current pregnancy. * allergy to misoprostol or letrozole. * medical disorder that contraindicate induction of abortion (e.g. heart failure).

Keywords: letrozole misoprostol first-trimester pretreatment
posture and pulmonary function of mouth-breathing children

Conditions: Mouth Breathing

Summary: the purpose of this study is to characterize the posture and respiratory function of mouth-breathing children.

mouth-breathing children presents changes in stomatognathic system, which results in head projection, tension augment in scapular belt muscles and postural adaptations. although thoracic shape and posture can influence ventilatory dynamics, we didn't find studies addressing pulmonary function of mouth-breathing children. this was a transversal study, designed to analyze the posture of mouth-breathing children, and verify the existence of correlation between posture and pulmonary volumes.

Eligibility criteria:
inclusion criteria: * nasal breathing (normal subjects group) or mouth breathing (mouth-breathing group), and the age between eight (08) and twelve (12) for both groups. exclusion criteria: * prior physiotherapeutic treatment or in process, presence of diagnostic or report on acute or chronic pulmonary disease, neurofunctional or cognitive impairment and alteration of the osteomuscular system.

Keywords: respiration respiratory disorders otolaryngology otorhinolaryngology posture
intra-laryngeal implant for treatment of chronic aspirations

Conditions: Aspiration Pneumonia; Tracheostomy Complication

Summary: this study evaluates the medical device newbreez ld is designed to protect the lower airways from saliva, liquids and food aspirations in tracheotomized patients suffering from chronic aspirations that require specific care and may lead to complications, including inhalation pneumonia.

patients suffering from swallowing disorders characterized by chronic aspirations (repeated episodes of aspirations defined as penetration of material - liquids, food, saliva, into the respiratory system due to a malfunctioning of the swallowing mechanism) are subject to pathologies and pulmonary insufficiencies. the risks of aspiration pneumonia or suffocation are significantly greater if the patient is not able to expectorate and thus engages the vital prognosis. there are several methods to treat chronic aspirations: the least invasive methods involve adopting postures and/or positions of the body during swallowing and adapting food textures; when these treatments are insufficient there is the need to recur to more advanced ones to protect the airways and keep the patient on a sufficient nutrition. for these severe cases, heavier surgical methods can be also considered. these methods lead to important anatomical changes, with a variable degree of reversibility, up to irreversibility (eg total laryngectomy). among surgical methods, there is also an implant of a tracheotomy cuffed cannula that allows patient to breathe through a hole in the trachea. the efficacy of this solution is highly controversial as reported by numerous studies and several adverse effects are reported on the tracheal duct. due to the interest of a prosthetic treatment and the disadvantages of the current methods and devices, protip medical has developed a closed intra-laryngeal implant: newbreez ld. this device is innovative because its geometry has been optimized to conform totally to the anatomy of the larynx with the aim to ensure a sealing against saliva, liquids and food aspirations.

Eligibility criteria:
inclusion criteria: * swallowing disorders characterized by chronic aspirations; * tracheotomy performed, inter alia, in the management of swallowing disorders; * aged over 18; * willing and able to comply with the requirements of the study; * informed consent signed; * affiliated patient or beneficiary of the social security system. exclusion criteria: * do not implant in patients with incomplete cricoid cartilage (surgery or other); * do not implant in patients with tracheotomy performed by cricothyroidectomy or between cricoid cartilage and the 1st tracheal ring; * do not implant in patients with tracheal lumen in the 1st tracheal ring, the lateral and anteroposterior diameters of which are less than 11 mm; * do not implant in patients with tight trismus; * do not implant in subjects less than 18 years of age; * do not implant in patients with bleeding disorders; * do not implant in patients contraindicated to general anesthesia.

Keywords: severe aspiration
evolution of pulse pressure following initiation of antihypertensive therapy in patients with essential arterial hypertension

Conditions: Hypertension

Summary: the main purpose of this prospective, multicentre, french observational study is to analyse the evolution of pulse pressure (pp) and to identify its prognostic factors in hypertensive patients three months after initiation of a new hypertensive therapy. the pp is defined as the difference between systolic blood pressure (sbp) and diastolic blood pressure (dbp).


Eligibility criteria:
inclusion criteria: * patients with essential arterial hypertension needing a new antihypertensive therapy * a patient was included by the physician only if he/she had agreed after being informed about the study exclusion criteria:
dual site left ventricular (lv) pacing

Conditions: Congestive Heart Failure; LV Dysfunction

Summary: the purpose of this study is to compare dual lv (left ventricular) pacing to standard single lv pacing (biv pacing) to see if dual lv pacing: 1. improves the way the heart's left ventricle functions 2. decreases the number of hospital and clinic visits for heart failure related symptoms 3. slows the rate patients experience certain heart failure symptoms 4. reduces uncoordinated heart contractions


Eligibility criteria:
inclusion criteria: * moderate or severe heart failure, defined as nyha class iii-iv despite optimal pharmacological heart failure therapy * on heart failure medical regimen (beta blockers and ace-i or arb's) for at least one month before randomization * a 12-lead electrocardiogram (ecg) obtained no more than 90 days prior to enrollment documenting a qrs duration \> 120 ms * left ventricular ejection fraction (lvef) \< 35% or equal * willing and capable of undergoing the device implant procedure and participating in all testing associated with this clinical study * have a life expectancy of more than 180 days, per physician discretion * age 40 or above, ensuring of legal age to give informed consent specific to state and national law exclusion criteria: * have had previous cardiac resynchronization therapy or a previous coronary venous lead * unable to perform a six-minute hall walk (6mhw) test * have an atrial tachyarrhythmia that is permanent (i.e., does not terminate spontaneously and cannot be terminated with medical intervention)without chb or planned avj ablation prior to randomization * have an atrial tachyarrhythmia that is persistent (i.e. can be terminated with medical intervention, but does not terminate spontaneously) without planned and successful cardioversion prior to randomization (patients with unsuccessful cardioversions and no avj ablation will be exited.) * have hypertrophic obstructive cardiomyopathy or infiltrative cardiomyopathy (e.g., amyloidosis, sarcoidosis) * have a mechanical tricuspid prosthesis * has severe aortic or mitral stenosis * enrolled in any concurrent study that may confound the results of this study * patients who are or suspect they may be pregnant or plan to become pregnant
validation of a cdsa strategy to reduce antibiotic prescription in senegal

Conditions: Malaria; Dengue; Influenza -Like Illness; Diarrhea; Pneumonia; Acute Febrile Illness

Summary: this trial aims to validate a novel clinical care strategy based on a electronic clinical decision support algorithm (cdsa) combined with point of care rapid diagnostic tests by evaluating its impact on antibiotic prescription and clinical outcome of children and adolescent presenting at primary healthcare facilities with non-severe acute illness compared to routine practice. the trial also aims to assess the usability of the cdsa strategy. the study will be conducted in primary healthcare facilities across different epidemiological regions of senegal.


Eligibility criteria:
inclusion criteria: * ongoing fever or diarrhea * ongoing fever will be defined objectively or as a reported fever, defined as : axillary temperature ≥37.5°c or tympanic, oral or rectal temperature ≥38.0°c; and fever duration ≤ 10 days * ongoing diarrhea will be defined as at least 3 abnormal stools during the last 24hrs * first consultation for the current illness * feasibility of contact between the patient (or his/her designated relative) and the study team at day 3 and day 7 * written informed consent by the caretaker/legally acceptable representative exclusion criteria: * infants less than 6 months of age * age ≥ 15 years * clinical status requiring immediate transfer to an appropriate care facility/ severe illness

Keywords: clinical algorithms mhealth integrated management for childhood illness
efficacy of pythagorean self-awareness for aging biomarkers improvement, in t2d patients and healthy individuals.

Conditions: Type 2 Diabetes Mellitus; Telomere Shortening

Summary: the present study explored the effects of the implementation of the pythagorean self awareness intervention (psai) on the dynamics of stress-related aging factors of immune cells in healthy volunteers and a cohort patients with type 2 diabetes mellitus . the primary aim was to evaluate the effectiveness of psai on two key biomarkers of biological age, telomere length and proteasome levels, indicative of the crosstalk between cellular oxidative status and replicative potential, with respect to metabolic, hormonal and mental status changes. secondary aims of this study included reduction of depression, perceived stress, anxiety and the establishment of lifestyle changes to enhance the quality of everyday life, including better quality of sleep, eating behaviours and an overall healthier status.

study design this non randomized non blinded parallel trial was conducted at the laiko hospital of athens, diabetes centre, first department of propaedeutic internal medicine of attica, greece, from 4.10.2018 to 26.11.2019. the study protocol was approved by the ethics committee of the laiko hospital (protocol number 5134/5-4-19) and was in accordance with the declaration of helsinki. all participants were enlisted in the study only after being fully informed by the researcher about the aims and procedures of the research and submitting written consent. procedures patients eligible for the above mentioned criteria were randomized in two groups: the group of healthy adult volunteers, and adults with type 2 diabetes who attended the outpatient diabetes clinic. this study was non-blinded, as patients and researchers were aware of the group assignment.

Eligibility criteria:
inclusion criteria: * adequate knowledge of the greek language * for participants with t2dm, a minimum of 3-month stable antidiabetic, hypolipidemic and antihypertensive treatment * habitants of athens, greece exclusion criteria: * participation in other stress management program * corticosteroid intake * diagnosis of psychiatric co-morbidity or autoimmune disease * change in antidiabetic, hypolipidemic, and antihypertensive treatment within the previous 3 months * patients with type 2 diabetes treated with insulin

Keywords: stress physiology behavioural intervention stress management type 2 diabetes pythagorean self-awareness
virtual reality based vision test in patients with amd

Conditions: Age-Related Macular Degeneration

Summary: to assess the usability, tolerability, and repeatability of the set of vr headset-based tasks.

in order to bridge the gap between the existing functional measures and amd lesions, researchers are considering the use of vr tools. this study is designed to assess the contrast sensitivity function mapping test (csf radial sweep) in an elderly population with amd. the primary objective of this study is to assess the usability, tolerability, and repeatability of the set of vr headset-based tasks. the secondary objective of this study is to assess the relationship between the metrics generated by vr-based functional tasks and the metrics derived from conventional clinical measurements of retinal anatomy and visual function. the primary efficacy endpoint is the contrast sensitivity function (csf) area under curve (auc) correlation to snellen bcva.

Eligibility criteria:
inclusion criteria: 1. subjects ≥18 years of age diagnosed with amd 2. subject snellen bcva score is 20/100 or better 3. ability to undergo quality optical coherence tomography (oct) imaging 4. willing and able to give written informed consent exclusion criteria: 1. unwilling to use headset 2. previous negative experience with a vr headset (eg, motion sickness, discomfort) 3. any known oculomotor impairment that would impact the ability of the subject to perform the tasks (eg, nystagmus, proptosis, apraxia of eyelid opening) 4. any manifest neurological or cognitive condition that would impair the subject's understanding or performance on the test (eg, alzheimer's disease, parkinson's disease) 5. any physical limitations that would prohibit the use of the vr headset (eg, neck problems)
to demonstrate the relative bioavailability of atenolol tablets, 100 mg

Conditions: Angina; Hypertension

Summary: to demonstrate the relative bioavailability of atenolol tablets, 100 mg.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal finding on physical exam, medical history, or clinical laboratory results on screening. exclusion criteria: * positive test results for hiv or hepatitis b or c. * treatment for drug or alcohol dependence.

Keywords: angina (chest pain) hypertension
the impact of hypo-osmolar drops on contact lens comfort

Conditions: Contact Lens Related Dry Eye

Summary: this pilot study will investigate the impact of sterile saline drops that are formulated at hypo-osmolar levels on cl comfort in comparison to an iso-osmolar drop, in a group of symptomatic cl wearers.


Eligibility criteria:
inclusion criteria: * is at least 17 years of age; * has full legal capacity to volunteer; * has read and signed an information consent letter; * is willing and able to follow instructions and maintain the appointment schedule; * is willing and able to stay within the school of optometry and vision science building for the duration of each study day; * currently wears daily, soft, frequent replacement lenses licensed in canada (daily, bi-weekly or monthly disposable lenses, no extended wear, no monovision) for at least 3 days/week and 6 hours/day during the 2 months prior to enrolment; * is symptomatic according to the following classification: * reports a difference between average and comfortable wear time with habitual lenses of at least 3 hours; * fall into the symptomatic group as per young's criteria (appendix 4). * is able to remove and insert the lenses by themselves; * owns a wearable pair of spectacles; * is willing to wear the study lenses for 10 hours; * has visual acuity (va) correctable to logmar 0.20 or better in each eye; * shows an acceptable lens fit with their habitual lenses; exclusion criteria: * is participating in any concurrent clinical or research study; * has any known active\* ocular disease and/ or infection; * has any ocular abnormality that would contraindicate contact lens wear; * has any known infection or inflammation that requires treatment or has a systemic condition that in the opinion of the investigator may affect the study measures; * is using any systemic or topical medications that in the option of the investigator may affect the study measures; * has any known sensitivity to the diagnostic pharmaceuticals and products to be used in this study; * is pregnant or lactating (by verbal communication) due to potential ocular physiology changes that may affect the study outcome; * is aphakic; * has undergone refractive error surgery; * is a member of the cclr directly involved in the data collection. \*for the purpose of this study, active ocular disease is defined as an infection or inflammation that requires therapeutic treatment. mild (i.e. not considered clinically relevant) lid abnormalities (blepharitis, meibomian gland dysfunction, papillae), corneal and conjunctival staining and dry eye are not considered an active ocular disease. neovascularization and corneal scars are the result of previous hypoxia, infection or inflammation and are therefore not active.