Kornimate/medical-research-clean huggingface dataset:
short course radiation therapy in palliative treatment of brain metastases

Conditions: Brain Metastases; Radiotherapy; Palliative Care

Summary: aim of the study is to assess efficacy of a short course radiation treatment in patients with symptomatic brain metastases from solid tumors

standard treatment for brain metastases (3000 cgy in 10 daily fractions of 300 cgy each) is compared with experimental treatment (1800 cgy in 4 fractions of 450 cgy twice a day) to demonstrate non-inferiority of this scheme

Eligibility criteria:
inclusion criteria: * symptomatic brain metastases from solid tumors * age \> 18 years * ecog performance status 0-3 * no changes in supportive care in the week before radiotherapy exclusion criteria: * pregnancy * previous irradiation of the same region

Keywords: short course radiotherapy symptomatic brain metastases
eosinophilic esophagitis treatment: montelukast vs fluticasone

Conditions: Eosinophilic Esophagitis; Dysphagia

Summary: this study will compare response to treatment of eosinophilic esophagitis with montelukast vs standard therapy fluticasone. investigators hypothesize that montelukast is equally effective in treating symptoms and histology of eoe when compared to fluticasone. the study will be conducted at multiple sites with medical college of wisconsin as the coordinating site. after identification and recruitment all patients will be randomized (provider blinded) to one of two medications: montelukast 10mg po qday vs fluticasone 440mcg po bid. patients will also complete a pretreatment, 6 week therapy and 12 week therapy questionaire. they will then undergo a repeat endoscopy to evaluate endoscopic and histologic response.

eosinophilic esophagitis is an allergic condition of the esophagus with an incidence that is on the rise, and has limited treatment options. current gold standard of treatment is with topical steroids (swallowed fluticasone). there is preliminary data that oral montelukast may prove to be effective in inducing and maintaining symptomatic along with histologic remission of this disease. investigators will be comparing the effectiveness of singulair to swallowed fluticasone in inducing and maintaining histologic and symptomatic remission of eosinophilic esophagitis.

Eligibility criteria:
inclusion criteria: * patients with a confirmed diagnosis of eoe on biopsy * with \>15 eos per hpf * ages \>18 * both male and female. * not pregnant exclusion criteria: * pregnancy * patients receiving ongoing medical therapy for eoe * patients who underwent dilation in the last 12 weeks with improvement in symptoms * la grade b or worse erosive esophagitis. * age \< 18 * nursing mothers * use of prohibited concomitant medications : budesonide-oral compounded liquid, fluticasone or montelukast.
mechanical control of plaque in patients with cerebral palsy: a randomized clinical trial

Conditions: Cerebral Palsy;; Dental Plaque

Summary: the aim of the present study was to determine the effectiveness of brushing with an electric toothbrush switched on and switched off in comparison to manual brushing for the removal of dental plaque in children aged four to 16 years with cerebral palsy.

advances in the design and type of movement of electric toothbrushes can determine the increase in effectiveness in the control of biofilm by caregivers and patients.there is a paucity of studies evaluating the effectiveness of the electric toothbrush compared to manual toothbrush specifically in patients with cerebral palsy.only one study used the electric toothbrush in patients with cerebral palsy and demonstrated superiority of the electric toothbrush over the manual. however, the study investigated the effect of various cleaning strategies on symptoms of gingival inflammation, not specifically focusing on the comparison of the efficiency of removal of biofilm from the manual toothbrush and electric toothbrush. the primary objective of this study was to evaluate the effectiveness of the electric brush on and off the removal of dental plaque in subjects with cerebral palsy compared to manual toothbrush. the secondary objective was to characterize the study as socioeconomic population.

Eligibility criteria:
inclusion criteria: * medical diagnosis of cerebral palsy exclusion criteria: * who did not complete the cycle three brushings

Keywords: cerebral palsy; toothbrushing; dental plaque
cerebral microstructural changes following mild traumatic brain injury

Conditions: Brain Concussion

Summary: this study examine the possible microstructural changes in the middle brain after mtbi using diffusion mri

there is a need for clinical and biological markers at 2-3 month to screen people in risk of getting chronic post-concussion symptoms (pcs) but also biomarkers in the brain to find out if this group with prolonged symptoms has measurable changes in the brain which could explain the persisting symptoms. several biomarkers and brain areas have been investigated as possible sites of injury after mild traumatic brain injury (mtbi). the nature of the diffuse pcs makes corpus callosum (cc), thalamus (tha) and hippocampus (hip) interesting because of their central position and connection to widespread motor, sensory and cognitive processes and other brain areas. in most prior studies conventional magnetic resonance imaging (mri) has failed to detect pathology especially in the later phase. diffusional kurtosis imaging (dki) and diffusional tensor imaging (dti) are more sensitive to microstructural changes and might serve as biomarkers in the middle brain after mtbi. it is hypothesized that there will be a difference in the microstructure of the thalamus, corpus callosum and hippo campus as measured with dki between two groups of mtbi subjects with and without pcs. secondary it is hypothesized that dki are more sensitive than dti in the measure of microstructural changes.

Eligibility criteria:
inclusion criteria: * concussion caused by a head trauma according to the diagnostic criteria recommended by the danish consensus report on commotio cerebri within the last 2-5 months. the criteria are based recommendations by the who task force, but with the amendment, that there must have been a direct contact between the head and an object in order to rule out acceleration - deceleration traumas. * age 18 to 30 years at the time of the head trauma. * able to understand, speak and read danish. * patients with symptoms at least three items on the rivermead post concussion symptoms questionnaire (rpq) rated as moderate or severe problem. pcs have to be subjectively rated as causing substantial impairment in daily life. patients with out symptoms (controls) having no problems on the rpq. exclusion criteria: * 1. objective neurological findings from neurological examination and / or acute trauma ct scan, indicating neurological disease or brain damage. * previous concussion leading to persistent pcs within the last two years. * severe misuse of alcohol, prescription drugs and / or illegal drugs. * psychiatric morbidity or severe neurological disease that impedes participation in the treatment, i.e. bipolar disorder, autism, psychotic disorder (life time), multiple sclerosis etc.. * suitable for mri examination
milking versus delayed cord clamping in full term neonates

Conditions: Neonatal Anemia

Summary: to compare the short term risks and benefits of cord milking 5 times toward the neonate with delayed cord clamping for 120 seconds in the full term neonate delivered by cesarean section.

abstract context: milking of the umbilical cord toward the neonate 5 times and delayed cord clamping both are good procedures to prevent anemia in neonates . objective: to investigate the effects of delayed umbilical cord clamping for 120 seconds, compared with milking of the cord 5 times toward the neonate on hemoglobin level after 6 weeks, intubation,respiratory distress,clinical jaundice,neonatal intensive care unit (nicu) admission,apgar score (after 5 minutes of delivery). -maternal,need for blood transfusion,additional need for therapeutic uterotonics,post postpartum hemorrhage (blood loss \> 500cc),intensive care unit admission. design: randomized controlled trial. setting: ain shams university maternity hospital. participants:300 full term infants born after a low risk pregnancy by cesarean section delivery. intervention: infants were randomized to delayed umbilical cord clamping (≥120 seconds after delivery) or cord milking (5 times to ward the neonate).

Eligibility criteria:
inclusion criteria: * pregnant females going for cesarean section that completed 37 weeks of gestation * medically free exclusion criteria: * known congenital anomalies of fetus. * rhesus sensitization. * fetal hydrops. * medical disorder (preeclampsia - diabetes mellitus - hypertension - sle). * need for urgent resuscitation. * multiple pregnancies.
effects of different flow anesthesia on atelectasis

Conditions: Atelectasis; Due to Anesthesia; General Anesthesia; Low- Flow Anesthesia; Minimal Flow Anesthesia

Summary: evaluation of atelectasis that may be caused by different flow rate anesthesia applications during the operation with lung ultrasound score.


Eligibility criteria:
inclusion criteria: * operation time 2-5 hours * elective septoplasty and rhinoplasty * asa i-ii exclusion criteria: * morbid obesity * malignant hyperthermia * opioid sensitivity * alcohol or drug addiction * congestive heart failure * chronic obstructive pulmonary disease * coronary artery disease * anemia * liver and kidney diseases * pregnancy * breast-feeding * history of allergy to drugs used

Keywords: lung ultrasound score minimal flow anesthesia atelectasis
relationship between natural killer cells' ability to kill leukemia cells and the outcome of patients with acute myeloid leukemia previously treated with interleukin-2

Conditions: Leukemia

Summary: rationale: studying samples of blood and bone marrow from patients with cancer in the laboratory may help doctors predict response in patients previously treated with interleukin-2. purpose: this laboratory study is looking at the relationship between natural killer cells' ability to kill leukemia cells and the outcome of patients with acute myeloid leukemia previously treated with interleukin-2.

objectives: * correlate the in vitro lysis of autologous pre-treatment leukemic blast cells by interleukin-2 (il-2)-expanded natural killer (nk) cells with relapse-free survival of patients with acute myeloid leukemia (aml) who were treated with interleukin-2 (il-2). * correlate the expression of inhibitory (mhc class i) and activating ligands on aml blast cells with relapse-free survival of these patients. * correlate the expression of activating and inhibitory nk receptors on il-2-expanded cells with relapse-free survival of these patients. * compare the susceptibility to autologous nk cell lysis of leukemic blasts obtained at diagnosis with those blasts obtained at relapse of these patients. outline: this is a multicenter study. patients are stratified according to age (\< 60 vs ≥ 60 years) and cytogenetic risk category (favorable vs average vs poor). previously banked tissue samples of leukemic blast cells from bone marrow and natural killer (nk) cells from peripheral blood mononuclear cells are thawed and analyzed. surface expression on leukemic blasts of co-stimulatory molecules, known activating nkg2d ligands, and mhc class i inhibitory ligands to nk cell receptors are quantified by monoclonal antibody analysis and flow cytometry. mean cell fluorescence intensity (mcfi) of each ligand is correlated with relapse-free survival of the patients.

Eligibility criteria:
disease characteristics: * diagnosis of acute myeloid leukemia * prior treatment with interleukin-2 required * previously enrolled on clb-9621, clb-9720, or calgb-19808 * previously consented to companion leukemia tissue bank protocol calgb-9665 and stored the following specimens: * bone marrow blast cells procured at diagnosis and at relapse (when available) * peripheral blood mononuclear cells obtained in remission patient characteristics: age * 15 and over

Keywords: adult acute myeloid leukemia in remission recurrent adult acute myeloid leukemia adult acute myeloid leukemia with 11q23 (mll) abnormalities adult acute myeloid leukemia with inv(16)(p13;q22) adult acute myeloid leukemia with t(15;17)(q22;q12) adult acute myeloid leukemia with t(16;16)(p13;q22) adult acute myeloid leukemia with t(8;21)(q22;q22)
risk factors for progressive supranuclear palsy (psp)

Conditions: Progressive Supranuclear Palsy

Summary: progressive supranuclear palsy (psp) is the most common atypical parkinsonian movement disorder. this study will determine the role of specific genetic, occupational and environmental components in the development of psp by evaluating patients with this disorder and age and gender matched controls.

this proposal will determine: (1) if there is an association between psp and specific genes of interest; (2) if there is an association between psp and occupational and/or environmental chemical exposures functionally or structurally similar to known parkinsonian toxicants; and (3) if hypertension or traumatic brain injury prior to symptom-onset is associated with psp. to disentangle the complex etiology of psp, this case-control multicenter study involves 500 psp cases, 500 age/gender matched primary controls, and 500 secondary controls for genetic confirmation. understanding the etiology of psp may also help explain the causes of other related diseases such as alzheimer's disease. this multidisciplinary team of movement disorder specialists, epidemiologists, geneticists, biostatisticians, industrial hygienist and toxicologist is well suited to unravel the etiology of psp.

Eligibility criteria:
inclusion criteria: * psp patients able to visit one of the screening sites for diagnostic confirmation and able to participate in a one hour telephone interview exclusion criteria: * no other major neurological disorders * unable to communicate by telephone

Keywords: progressive supranuclear palsy epidemiology case-control genetic environmental neurodegenerative disease movement disorders atypical parkinsonism parkinson plus steele-richardson-olszewski psp
manville moves: an exercise intervention for behavioral regulation among children with behavioral health challenges

Conditions: Autistic Disorder; Attention Deficit and Disruptive Behavior Disorders; Anxiety Disorders; Mood Disorders; Conduct Disorder; Oppositional Defiant Disorder

Summary: the purpose of this study is to examine whether an exergaming, aerobic physical education (pe) curriculum is acceptable and elicits improvements in behavioral self-regulation and classroom functioning among children with behavioral health challenges attending a therapeutic day school. after following an approved consent/assent process, children attending the school were randomized by classroom to take part in either 7 weeks of the experimental pe curriculum, or 7 weeks of the standard pe curriculum; after a 10 week washout period, children then crossed over into the other arm.


Eligibility criteria:
inclusion criteria: * attending the manville school at the time of study initiation exclusion criteria: * medical exemption from physical education classes * parental opt out from physical education classes
enhanced smoking cessation intervention for smokers exposed to the world trade center (wtc) disaster

Conditions: Cigarette Smoking; Post Traumatic Stress Disorder; Signs and Symptoms, Respiratory

Summary: the purpose of this study was to test the efficacy of a cbt-based smoking cessation treatment enhanced with transdiagnostic skills for the management of anxiety and fear-based avoidance behaviors (cbt-a) relative to a standard cbt-based smoking cessation treatment (cbt-s) for smokers with elevated ptsd symptoms who were exposed to the 9/11 world trade center disaster. the investigators hypothesized that the cbt-a treatment would yield more favorable outcomes with regard to smoking abstinence as well as improvements in ptsd and respiratory symptoms over a 6-month follow-up period.

respiratory illness and post-traumatic stress disorder (ptsd) are the primary health sequelae of the world trade center (wtc) disaster on september 11th 2001 and are often comorbid. cigarette smoking is a modifiable health behavior associated with both lower respiratory symptoms (lrs) and ptsd. smoking cessation programs are considered the crucial front-line intervention for smokers with pulmonary problems. unfortunately, trauma exposed smokers with elevated ptsd symptoms have greater difficulty quitting, are more likely to fail standard cessation programs, and are more likely to relapse than smokers with other anxiety disorders and those without mental illness. interventions that concurrently target mechanisms thought to maintain the comorbidity between ptsd and lrs (e.g., anxious reactivity to nicotine withdrawal, smoking to reduce negative affect) may offer a means of improving smoking quit rates in trauma exposed populations. thus, the purpose of this study was to test the efficacy of a combined cbt smoking cessation treatment enhanced with transdiagnostic skills for the management of anxiety and fear-based avoidance behaviors (cbt-a). the investigators randomized 90 wtc disaster exposed daily smokers with elevated ptsd symptoms to either cbt-a (n=44) or a standard cbt-based smoking cessation program (cbt-s; n=46). participants were followed up to six months post-treatment.

Eligibility criteria:
inclusion criteria: * smoking at least five cigarettes per day * reporting interest in smoking cessation treatment * direct exposure to the wtc disaster (e.g., responding to the event or witnessing the event in person) * scoring \>30 on the posttraumatic stress disorder checklist exclusion criteria: * current participation in another smoking cessation treatment * alcohol dependence within the last six months * serious mental illness (e.g., psychosis, mania)

Keywords: post traumatic stress disorder ptsd cigarette smoking lower respiratory symptoms cognitive behavioral therapy cbt transdiagnostic treatments world trade center
a study to compare the response to treatment with abatacept vs adalimumab, on background methotrexate, in adults with early, seropositive, and shared epitope-positive rheumatoid arthritis and an inadequate response to methotrexate

Conditions: Rheumatoid Arthritis

Summary: the purpose of this study is to evaluate the superiority in efficacy of abatacept compared with adalimumab, on background methotrexate, in adults with early, seropositive, and shared epitope-positive rheumatoid arthritis and an inadequate methotrexate response.


Eligibility criteria:
inclusion criteria: * early rheumatoid arthritis (ra), defined as symptoms of ra that started ≤ 12 months prior to screening and satisfied the american college of rheumatology/european league against rheumatism (acr/eular) 2010 criteria for the classification of ra at some point during the 12-month period * naïve to any targeted (biologic or nonbiologic) disease-modifying antirheumatic drugs (dmards), conventional synthetic dmards other than methotrexate (mtx), or investigational therapies for ra * treated with mtx for at least 12 weeks, with a stable dose of oral or parenteral mtx for at least 4 weeks prior to randomization * anti-cyclic citrullinated peptide-2 (anti-ccp-2) test that is \> 3× the upper limit of normal and are positive for rheumatoid factor (rf) according to central lab testing during screening * at least a disease activity score 28-joint count calculated using c-reactive protein (das28-crp) ≥ 3.2 at screening * at least 3 tender and at least 3 swollen joints at screening and at randomization exclusion criteria: * women who are breastfeeding * autoimmune disease other than ra (e.g., psoriasis, systemic lupus erythematosus \[sle\], vasculitis, seronegative spondyloarthritis, inflammatory bowel disease, sjogren's syndrome) or currently active fibromyalgia * history of or current inflammatory joint disease other than ra (e.g., psoriatic arthritis, gout, reactive arthritis, lyme disease) * at risk for tuberculosis * recent acute infection * history of chronic or recurrent bacterial infection (e.g., chronic pyelonephritis, osteomyelitis, bronchiectasis) * history of infection of a joint prosthesis or artificial joint * history of systemic fungal infections (such as histoplasmosis, blastomycosis, or coccidiomycosis) * history of primary immunodeficiency * current clinical findings or a history of a demyelinating disorder * 5 or more joints cannot be assessed for tenderness or swelling other protocol-defined inclusion/exclusion criteria apply

Keywords: abatacept adalimumab bms-188667 humira® methotrexate orencia® rheumatoid arthritis
healthy lifestyle intervention in patients with systemic lupus erythematosus: the living well with lupus study

Conditions: Systemic Lupus Erythematosus

Summary: this research program aims to investigate the clinical, physiological, metabolic and molecular effects of lifestyle change in patients with systemic lupus erythematosus with high cardiovascular risk. this 6-month parallel-group randomized controlled trial aims to investigate the feasibility and efficacy of a newly developed lifestyle change intervention - through recommendations for structured and unstructured physical activity and healthy eating - on increasing physical activity level and improving eating habits. potential effects of the intervention on cardiovascular and cardiometabolic risk factors, health-related quality of life, symptoms of anxiety and depression, sleep quality and immune function will be investigated. gold-standard techniques and a variety of analyses will be performed to access the potential mechanisms involved in response to this intervention.


Eligibility criteria:
inclusion criteria: * women between 18 and 65 years old diagnosed with systemic lupus erythematosus * one or more high cardiovascular risk factors * sledai score ≤ 4 * treatment with prednisone at a dosage \<10 mg/d and treatment with hydroxychloroquine in a stable dose exclusion criteria: * another rheumatic diseases (except for secondary sjogren's syndrome) * participation in structured exercise training programs and/or prescriptive diets * illiterate or with diagnosed cognitive disorders or musculoskeletal impairments that potentially compromise understanding and participation in the intervention

Keywords: life style behavioral intervention cardiovascular risk life quality
repetitive transcranial magnetic stimulation in treatment and prophylaxis of chronic migraine in patients with no prophylactic treatment for the last 3 months

Conditions: Chronic Migraine

Summary: compared with the patients with episodic migraine those with chronic migraine have worst quality of life and more severe headache related disability we investigate repetitive transcranial magnetic stimulation in treatment and prophylaxis of chronic migraine


Eligibility criteria:
inclusion criteria: * a study sample of patients with chronic migraine according to international classification of headache disorders-3 (ichd-3). * patients are regular on follow up visits. exclusion criteria: * patients with depression by hamiliton scale of depression by using its arabic version translated by dr lotfy fateem * patients on prophylactic medications for chronic migraine. * pregnancy. * cochlear implants, cardiac pacemaker, and metal body implanted in head-and-neck region. * patients refused to give informed consent. * history of seizures.