Kornimate/medical-research-clean huggingface dataset:
the effect of platelet rich plasma injection combined with exercise rehabilitation in patients with rotator cuff tear

Conditions: Rotator Cuff Tear

Summary: this study aims to evaluate the effect of platelet rich plasma combined with exercise therapy for patients with partial thickness rotator cuff tears.

the purpose of this study is to exam the outcome of rotator cuff tear patients who received platelet rich plasma injection followed by rehabilitative exercise. the specific aim of this study is to determine the outcomes of treatment of partial thickness rotator cuff tears with platelet rich plasma (prp) and rehabilitative exercise. subjects with partial thickness rotator cuff tears will be designated to receive an injection of prp or hyaluronic acid, followed by rehabilitative exercise. shoulder function and tendon healing will be evaluated using the patient surveys as well as ultrasound. subjects will be followed for 3 months to determine the outcomes of the treatment. the hypothesis is that there is no difference in healing rate or functional outcomes in patients treated with prp injections plus rehabilitative exercise compared with hyaluronic acid injection plus rehabilitative exercise for the treatment of partial thickness rotator cuff tears.

Eligibility criteria:
inclusion criteria: * age between 40 and 85 years old, without significant cognition impairment (mmse\>20) * shoulder pain score(nrs)\> 5 * partial tear of supraspinatus tendon, proved by ultrasonography or mri * patients who signed informed consent * patients who agreed to stop using analgesics during the experimental period exclusion criteria: * thrombocytopenia (platelets less than 15000 per microliter) * patient who is using anticoagulant or has history of coagulation dysfunction * uncontrolled infection * end stage malignant disease * infection or other skin condition over injection site * history of shoulder or humeral fracture, dislocation or operation * psychiatric problems that precludes informed consent or inability to read or write * other serious problems that preclude participation of the study

Keywords: rotator cuff tear platelet rich plasma ultrasound exercise hyaluronic acid
sleep self-regulation using mental imagery

Conditions: Sleep Deprivation; Insomnia

Summary: this randomised controlled trial assessed the efficacy of four mental imagery techniques for improving sleep and its related behaviour: (1) imagery focused on reducing arousal levels; (2) imagery incorporating implementation intentions (a strategy designed to link specified behaviour with the anticipated context) for sleep-related behaviour; (3) a combination of imagery using arousal reduction and implementation intention strategies; or (4) a condition where participants were asked to imagine their typical post work activities.

sleep deprivation is a significant health issue in the modern workplace. we conducted a randomized controlled trial to test the efficacy of techniques involving mental imagery promoting relaxation (arousal reduction; ar) and simulation of the appropriate sleep behavior in the likely environments (implementation intentions; ii) in a population of daytime employees

Eligibility criteria:
inclusion criteria: * ability to read and write in english; * full-time employment; * work shifts during daytime hours (i.e., participants were excluded if they worked night shifts either through the organization or through a secondary job) in a position that provided daily access to email; * a score of five or greater on the pittsburgh sleep quality inventory (psqi) which indicates at least moderate difficulties in two or more areas (e.g., sleep quality and daytime dysfunction); exclusion criteria: * an identifiable biological cause of current sleep deprivation (e.g., sleep apnoea, narcolepsy, restless leg syndrome, periodic limb movement disorder, or pregnancy) * an identified psychological disorder * caring for a child under the age of 5 or have a reason outside of work that caused them to regularly lack sleep. * incomplete data (over 50% of daily data missing or missing final follow-up assessment

Keywords: sleep self-regulation implementation intentions intervention mental simulation
ayres sensory integration therapy on occupational performance in children with autism spectrum disorder

Conditions: Autism Spectrum Disorder

Summary: ayres sensory integration (asi) therapy is an individualized intervention designed to address specific underlying sensorimotor issues that may affect children's performance during daily routines and occupations. the intervention takes place in the context of play, emphasizes the active participation of the child, involves a collaborative relationship between the occupational therapist and the child, and focuses on participation-oriented outcomes that are collected at regular intervals throughout the intervention program. in general, its content is to improve the child's occupational performance. the program, which will be carried out in accordance with the ayres sensory integration fidelity measure®, it is aimed to reduce the autism-specific symptoms of the child with autism and the dependence of the child on the caregiver in self-care activities. it is predicted that this whole process will increase the participation and his performance of the child with autism in his occupations related to his daily life. h0: ayres sensory integration therapy has no effect on the occupational performance of the child with autism spectrum disorder.


Eligibility criteria:
inclusion criteria: * children diagnosed with autism spectrum disorder according to diagnostic and statistical manual of mental disorders, fifth edition * level 1 (requiring support) and level 2 (requiring substantial support) are severity levels for autism spectrum disorder * age at first and second test between 3 years and 10 years exclusion criteria: * accompanying neurodevelopmental, psychiatric, neurological or physical diagnosis

Keywords: ayres sensory integration occupational performance
preference between two autoinjectors in patients with rheumatoid arthritis and plaque psoriasis treated with etanercept

Conditions: Rheumatoid Arthritis; Plaque Psoriasis

Summary: the study will estimate the preference of rheumatoid arthritis (ra) and plaque psoriasis (pso) patients who self inject etanercept for one of two experimental autoinjectors.

candidates for treatment are those who in the determination of the investigator's standard of care and the caring physician's intent are to initiate treatment with etanercept. participants must be naïve to etanercept and naïve to other autoinjector pens or prefilled syringes and be able to self-inject. the study will consist of a 30 day screening period, and 2 treatment periods of 4 weeks duration each (one treatment period using autoinjector a and the other using autoinjector b). at the end of the study, participants may continue treatment with commercially available etanercept at the physician's discretion.

Eligibility criteria:
inclusion criteria: diagnosis of moderate to severe rheumatoid arthritis (ra) or moderate to severe plaque psoriasis (pso) and a candidate for treatment with etanercept in the opinion of the investigator in addition to the caring physician's intent to initiate treatment with etanercept. - naive to etanercept. - naive to other autoinjector pens or prefilled syringes for tumor necrosis factor (tnf)-inhibitor therapy or other subcutaneous biologics for ra. - willing to self-inject per investigator judgement at screening and capable of self-injection using the autoinjector a or b as documented at baseline by the investigator. - able to read and write in english. - exclusion criteria: latex allergy. - subject has an active infection (including chronic or localized infections) for which anti-infectives were indicated within 4 weeks prior to first dose of etanercept. - subject had prosthetic joint infection within 5 years of screening or native joint infection within 1 year of screening. * other criteria may apply.
prospective melanoma database

Conditions: Melanoma

Summary: in research on melanoma, translational research is the essential link between basic research and clinical research by facilitating the passage between discovery and improvement in the quality of patients care.that is the reason why it is very important to collect, and centralize clinical and biological data of patients with melanoma. the aim of the project is to provide to scientific community a structured, mixed clinical and biological database, unique in france, in order to insure accessibility to clinical data.

collection of clinical and biological data from patients with melanomas of any stage in a structured and centralized database

Eligibility criteria:
inclusion criteria: * age \> 18 years * histologically confirmed melanoma of any stage * affiliated to a social security system in france * who signed the informed consent exclusion criteria: * any psychiatric or medical condition that would make the patient unable to give a signed informed consent

Keywords: melanoma clinical biological database
an exploratory trial of azd3480 (tc-1734) for the treatment of adult attention-deficit/hyperactivity disorder (adhd)

Conditions: ADHD

Summary: a 3-way cross-over trial of two weeks of treatment with three drug conditions. azd3480 will be given in doses of (a) 5mg/day, (b) 50 mg/day and (c) placebo to 24 non-smoking adults with dsm-iv confirmed adhd. three week washout between each treatment period. cyp2d6 genotyping will be completed at screening and slow metabolisers will be excluded from participation in this study. cognitive, adhd symptom, safety and pharmacokinetic (pk) assessments will be made during each treatment period. safety and tolerability assessments will be a major component of the trial and all serious adverse events (sae) will be immediately (within 24 hours) reported to both targacept and to astrazenca.


Eligibility criteria:
inclusion criteria: * confirmed diagnosis of dsm-iv adhd * score of equal or more than 2 on at least six of nine items in at least one of the subscales of the connor´s adult adhd rating scale (caars-inv) * score of equal or more than 4 (at least moderate severity) on the clinical global impressions-severity (cgi-s) test exclusion criteria: * current dsm-iv axis i psychiatric disorder (other than adhd) * current user of cigarettes or other nicotine-containing product. * slow metabolizers as indicated by cyp2d6 genotyping. * use of drugs affecting cognitive function within 8 weeks prior to enrollment visit or intended use during the study.
drug-drug interaction - 3 arm - carboplatin/paclitaxel, dacarbazine

Conditions: Advanced Melanoma

Summary: the purpose of this clinical research study is to learn the pharmacokinetics of ipilimumab when combined with paclitaxel/carboplatin or dacarbazine


Eligibility criteria:
inclusion criteria: * histologic diagnosis of advanced malignant melanoma * eastern cooperative oncology group (ecog) performances status 0-1 * measurable/evaluable disease as per modified world health organization (mwho) criteria exclusion criteria: * evidence of active brain metastases * prior treatment with anti-cytotoxic lymphocyte antigen 4 (ctla-4) or anti-cd137 (type of tumor necrosis factor) antibody * total bilirubin greater than (\>) 1.5 \* upper limit of normal (uln) and aspartate aminotransferase (ast) or alanine aminotransferase (alt) \> 2.5 \* upper limit of normal (uln) * prior autoimmune disease * use of immunosuppressing therapies

Keywords: untreated advanced melanoma
deep learning signature for predicting the novel grading system of clinical stage i lung adenocarcinoma

Conditions: Lung Adenocarcinoma; Radiomics; Grading System

Summary: the purpose of this study is to evaluate the performance of a pet/ ct-based deep learning signature for predicting the grade 3 tumors based on the novel grading system in clinical stage stage i lung adenocarcinoma based on a multicenter prospective cohort.


Eligibility criteria:
inclusion criteria: (1) participants scheduled for surgery for radiological finding of pulmonary lesions from the preoperative thin-section ct scans; (2) the maximum diameter of lesion less than 4 cm on ct scans; (3) the maximum short axis diameter of lymph nodes less than 1 cm on ct scan; (4) the suvmax of hilar and mediastinal lymph nodes less than 2.5; (5) pathological confirmation of primary lung adenocarcinoma; (5) age ranging from 20-75 years; (6) obtained written informed consent. exclusion criteria: (1) multiple lung lesions; (2) poor quality of pet-ct images; (3) participants with incomplete clinical information; (4) mucinous adenocarcinomas; (5) participants who have received neoadjuvant therapy.
nanofat versus platelet poor plasma gel for infraorbital rejuvenation

Conditions: Tear Trough Eyelid Deformity

Summary: this study was conducted for evaluation of the clinical efficacy, safety, and potential side effects of platelet poor plasma gel versus nonfat injection in infraorbital rejuvenation


Eligibility criteria:
inclusion criteria: * all patients with infraorbital dark circles exclusion criteria: * pregnancy * breast feeding * infectious disorders

Keywords: platelet poor plasma gel nanofat infraorbital rejuvenation
the effect of using clinical guidelines on kangaroo care on newborn and maternal outcomes

Conditions: Premature Infants

Summary: the aim of this study was to determine the effect of the use of clinical guidelines in kangaroo care (kb) practice on neonatal and maternal outcomes in premature infants. the study was a single-blind, parallel group (experimental-control), randomized controlled experimental design with pretest-posttest design. it was carried out in the neonatal intensive care unit of selçuk university faculty of medicine hospital in konya province. study data were collected from 40 premature newborns between september 2022 and november 2022. premature infants in the intervention (n = 20) and control groups (n = 20) were determined by randomization method.

kangaroo care was applied to the intervention group with the kangaroo care guide created by reviewing the current literature, and kangaroo care was applied to the control group with the standard kangaroo care method of the clinic. data were collected using the descriptive information form, physiological parameters form, neonatal comfort behavior scale, nurse-parent support scale, parental satisfaction scale and kangaroo care guide/checklist for infants without respiratory support. premature infants were followed up with skin-to-skin contact with their mothers in kangaroo care for 65 minutes. in the study, physiological parameters and neonatal comfort behavior scale scores of premature infants and nurse-parent support scale and parental satisfaction scale scores of mothers were evaluated. pearson chi-square test, yates correction and fisher's exact test were used to compare categorical data according to groups. two independent sample t test was used to compare normally distributed variables and mann whitney u test was used to compare non-normally distributed variables. statistical significance level was accepted as p˂0.05.

Eligibility criteria:
inclusion criteria: for premature infants; * the baby is born before 36+6 weeks of gestation * stability of vital parameters at the time of application, * stable health status (cardiorespiratory stability, no congenital or chromosomal abnormalities, no history of intraventricular hemorrhage, no history of periventricular leukomalacia and nec, no systemic and metabolic disorders), for mothers; * willingness to participate in the research * being able to read and write turkish exclusion criteria: for premature infants; * being connected to a mechanical ventilator * congenital or chromosomal abnormality * being with deprivation syndrome * having a history of intraventricular hemorrhage for mothers; not being willing to care for kangaroos - having a physical disability to care for kangaroos

Keywords: kangaroo care evidence-based guideline prematurity nicu
effect of stent placement on short term survival of left sided obstructive colorectal cancers

Conditions: Colorectal Cancer

Summary: the aim of this observational study is to determine effect of stent placement on survival results in first three years in a patient who applied to the emergency department with obstruction due to colorectal cancer. eligible patients divided into two groups. group a includes patients underwent emergency surgery directly. patients underwent elective surgery following stent placement as bridge-to-surgery. patients underwent elective surgery following bridge-to-surgery stent placement were accepted as group b.

patients who applied to emergency department of a single tertiary referral center between january 2016 and december 2020 and diagnosed as left sided obstructive colorectal cancer were included in this retrospective study. all patients were equal or older than 18 years and histopathologically found to have primary colorectal malignant neoplasms. patients were excluded from the analysis if they met any of the following criteria: * who underwent emergency surgery due to unsuccessful stent application intervention or stent-related complications developed, * those with middle and lower rectum tumors or received neoadjuvant treatment, * perforation, * who underwent subtotal or total colectomy (as a result of colon ischemia in the cecum, microperforation, etc.), * recurrent disease patients * patients have metastasis

Eligibility criteria:
inclusion criteria: * all patients were equal or older than 18 years and histopathologically found to have primary colorectal malignant neoplasms and diagnosed as left sided (descending colon, sigmoid colon and upper rectum) obstructive colorectal cancer were included exclusion criteria: * who underwent emergency surgery due to unsuccessful stent placement intervention * who underwent emergency surgery due to stent-related complications * those with middle and lower rectum tumors * those received neoadjuvant treatment, * patients have perforation, * who underwent subtotal or total colectomy (as a result of colon ischemia in the cecum, microperforation, etc.), * who has a recurrent disease or metastasis.

Keywords: obstruction, bridge to surgery
promoting widowed elders lifestyle after loss

Conditions: Mood Disorders; Depression; Anxiety; Grief; Bereavement; Health Behavior

Summary: this study is for adults 60 years and older who are grieving the recent loss of a spouse or partner. bereavement is one of the most distressing transitions faced by older adults and triggers dramatic changes to older adults' daily routine which puts them at-risk for a mood disorder. the purpose of this study is to promote bereaved elders' mental health by focusing on healthy lifestyle practices. study treatment involves using a tablet to record their daily physical activity, diet, and sleep behaviors, for 12 weeks. the investigators follow-up with people for up to one year.

preventing mental health problems that develop following spousal bereavement is important because these conditions are highly prevalent and have lasting adverse consequences for the well-being of the bereaved survivor. the proposed research will evaluate the feasibility and acceptability of a healthy lifestyle intervention that uses a technology-based behavioral self-monitoring protocol to encourage engagement in physical activity, healthy eating, and good sleep practices following spousal bereavement. data from 10 participants will be used for the development of a prevention intervention manual (aim 1). a small pilot study will be conducted (aim 2) in which 50 participants will be randomly assigned to 12 weeks of (1) behavioral self-monitoring using a smartphone (n=20), (2) behavioral self-monitoring using a smartphone + motivational interviewing-based lifestyle coaching (n=20), or (3) enhanced usual care (n=10). blood samples will be collected to explore inflammatory cytokines as a potential mediator/moderator of mental health risk.

Eligibility criteria:
inclusion criteria: * 60 years and older * experiencing the recent death (within 8 months) of a spouse or partner * at-risk for developing mental health problems, based on high-risk markers defined as: subthreshold symptoms of depression (hamilton depression rating scale \[ham-d\]101 of 9-14), anxiety (generalized anxiety disorder scale \[gad-7\] ≥ 10, and/or complicated grief (inventory of complicated grief \[icg\] of 20-29), together with absence of current major depression, generalized anxiety, post-traumatic stress, or suicidiality; or high medical comorbidity (2 or more systems on the cirs-g), low social support (perceived isolation scale below zero), functional disability (limitation with at least 1 adl/iadl),or exclusion criteria: * current dsm-v criteria for syndromal mood, psychosis, anxiety, eating disorder, or substance abuse dependence; * dementia; 3ms\<80; * patients taking psychotropic medications to stabilize mental health problems including antidepressants and benzodiazepines;
impact study of community based treatment of neonatal infection by health extension workers on neonatal mortality

Conditions: Neonatal Infections

Summary: the purpose of the study is to determine whether community based management of infections with antibiotics administered by health extension workers reduce all cause mortality in neonates after the first day of life compared to current moh imnci model of referral to hospital

although 44% of neonatal deaths in ethiopia are due to infection, access to treatment for neonatal infections is very low for most families. even though the newly adapted integrated management of newborn and childhood illness (imnci) package includes assessment of newborns, if a baby has any danger signs that may be suggestive of infection and is taken to health posts, the baby is to be referred to hospital for treatment. given that only about 5% of neonatal deaths occur in hospitals and the distance to hospital is often far and the costs prohibitive, very few babies are likely to receive essential lifesaving antibiotics. evidence from india, bangladesh, and nepal demonstrates that community health workers can effectively manage neonatal infections at home. however it is not known whether and community-based management of neonatal infections is effective, feasible and acceptable in the ethiopian context. local evidence regarding lives saved and cost is required in order to inform health policy and programming regarding community-based treatment of neonatal infections.

Eligibility criteria:
inclusion criteria: * participants who give consent to be treated at health post by health extension worker exclusion criteria: * if newborn is critically sick

Keywords: ethiopia community community based health extension worker health extension program
video-based pelvic floor muscle therapy

Conditions: Pelvic Floor Disorder; Pelvic Floor Muscle Exercise

Summary: this study is a feasibility, pilot trial of remote, video-based pelvic floor muscle therapy (pfmt) for patients with pelvic floor disorders, including pelvic organ prolapse, urinary incontinence and anorectal dysfunction. pfmt has been shown to improve these symptoms in multiple studies.

this will be a feasibility and acceptability trial of a novel remote, web-accessible pfmt curriculum, designed by pelvic floor physical therapists. patients will be expected to complete a 5-10-minute survey at initial enrollment. they will have one in-person session with a pelvic floor therapist prior to starting the 8-week video-based pfmt course. afterwards, they will have a final in person session with a pelvic floor therapist along with a final set of surveys that should take an estimated 10-15 minutes. the primary objective is to the determine the feasibility and accessibility of using a video-based pfmt for patients with pelvic floor dysfunction. the secondary objective is to determine whether video-based pfmt can improve symptomatology and quality of life.

Eligibility criteria:
inclusion criteria: * diagnosis of pelvic floor dysfunction with referral for pfr * english-speaking exclusion criteria: * unable to access web-based videos * unable to speak english