Kornimate/medical-research-clean huggingface dataset:
partnership and dignity: a mixed-methods survey on supporting and retaining uganda's village health teams

Conditions: Malaria; Diarrhea; Pneumonia

Summary: for more than a decade, uganda's ministry of health has led a community health worker program model in which village health teams (vhts), cadres of unpaid volunteers, are assigned the task of delivering preventative health services and education to their local communities. studies have demonstrated the effectiveness of uganda's vhts in improving certain health outcomes; however it is known that vhts are not optimally supported, and there has been vht attrition in recent years. the ministry of health has recognized the inadequate support of vhts thus far and is aiming to "expand vhts to all local governments and explore ways of sustaining vhts." the objective of this study is to evaluate the extent to which material support is a deciding factor in the efficiency and durability of uganda's vht initiative. material support may take the form of monetary stipends, regular payment, transportation assistance, or nonfinancial materials such as bicycles or mobile phone airtime. this study will review existing literature and gather novel data through surveys of vht members and vht stakeholders. the quantitative and qualitative survey data will be analyzed for trends that may point to a conclusion in the context of existing health policy discourse on community health worker remuneration. the purpose of this study is to strengthen the knowledge base on whether or not the current absence of material support significantly limits the potential for uganda's vhts to be sustained and expanded. this information can be used by governmental and non-governmental organizations in their work to strengthen and sustain vhts throughout the country.


Eligibility criteria:
inclusion criteria: vht subjects must have been actively working as a vht member for at least 6 months. stakeholders, that is, program managers, health administrators and policy makers, must be involved in managing, administrating, or guiding policy for vht programs as part of their official job description. these persons must also have been acting in those roles for at least 6 months. all study subjects will be 18 years of age or older. all study subjects will be literate and able to be informed to give or withhold consent of participation. exclusion criteria: there will be no exclusion or inclusion based on gender, race, tribal or ethnic affiliation, religion, or health status.
safety study of liver transplantation for hilar cholangiocarcinoma

Conditions: Hilar Cholangiocarcinoma

Summary: hilar cholangiocarcinoma is a highly malignant tumor. surgical resection or simple liver transplantation leads to poor prognosis accompanied by high recurrence rate and low survival rate. the newly proposed neoadjuvant therapy with liver transplantation strategy shows promising clinical application, which once reported 5-year survival rate 82%. however, transplantation centers conducting this kind of research are limited due to its complexity and long-term. the investigators would like to conduct a clinical trial for only unresectable hilar cholangiocarcinoma patients who should take neoadjuvant brachytherapy and chemoradiotherapy followed by orthotopic liver transplantation.

the enrolled patients should be prescribed with several examinations when admitted to hospital consisting of ct, mri, mrcp, ect, pet/ct and other laboratory tests. all preoperative examinations must indicate that enrolled individuals should be diagnosed as unresectable hilar cholangiocarcinoma. in addition, repetitive ercp manipulations are needed in order to obtain positive results by brush cytology. of course, all enrolled patients should be adherent to the fundamental principles of liver transplantation. we employed i-125 radioactive plastic stents (patent no: zl 201610116321.3) to conduct brachytherapy. each stent composed of a drainage tube with a stab at both ends that had a stabilizing effect. two opposite channels were made in the wall of stents paralleling the drainage lumen, with irradiation window in the lateral wall of the channel. the diameter of the channel is a bit smaller than that of the radioactive seeds, so as is the length and width of irradiation windows. the stents are so designed to immobilize seeds and radiate properly. the radioactive i-125 seeds were 4.5 mm long and 0.8 mm thick, and their half-life was 60.1 days. the nasobiliary radiography was performed to determine the length of involvement of bile duct.corresponding radioactive seeds are then put in appropriate location with biliary stents by ercp procedure. about a month later, external beam radiotherapy was administrated to a target dose of 30gy in 30 fractions, 1.5gy twice per day. concomitantly, intravenous capecitabine was given at 1.0g bid for two weeks, which is repeated after 14 days until transplantation. immunosuppressive therapy was provided with tacrolimus, mycophenolate and corticosteroids. corticosteroids were withdrawn a week later. chemotherapy was continued 1 month after olt with expected 3 courses.

Eligibility criteria:
inclusion criteria: unresectable hilar cholangiocarcinoma tumor diameter less than 3 cm adherence to liver transplantation requirements exclusion criteria: intrahepatic cholangiocarcinoma uncontrolled infection intrahepatic or extrahepatic metastasis distant lymph node metastasis
iron supplementation in hip/knee surgery

Conditions: Orthopedic Disorder; Hip Arthropathy; Knee Arthropathy; Anemia; Iron Poor Blood

Summary: randomized controlled trial to evaluate the efficacy of oral iron supplementation in reducing the prevalence of preoperative anemia in a cohort of 82 patients undergoing elective prosthetic hip or knee surgery.


Eligibility criteria:
inclusion criteria: * males and females * asa 1, 2, or 3 * no neuropsychiatric conditions * acceptance of informed consent * elective prosthetic hip or knee surgery exclusion criteria: * asa 4 * present or past neuropsychiatric conditions * hip or knee revision surgery * use of iron as dietary supplement * known erythrocytosis * incompatible hypersensitivities * iron metabolism disorders * lymphoproliferative disorders
registry hbot in dfu

Conditions: Diabetic Foot Ulcers

Summary: overview of available data to assess the benefits of hbot to dfu patients

10 year retrospective registry to measure outcomes regarding major amputations, mortality, hospital admissions in patients with a diabetic foot ulcer with peripheral ischaemia. two groups will be compared: complementary hbot and a control group.

Eligibility criteria:
inclusion criteria: * diabetes mellitus * meggitt-wagner classification grade 2-4, existing \> 4 weeks * complete 1 year follow-up exclusion criteria: * chronic obstructive pulmonary disease (copd) gold iv * treatment with chemotherapy, immunosuppressive drugs or systemic corticosteroids within the last 3 months * metastasized malignancy * left ventricular ejection fraction (ef) \<20% or external pacemaker * recent thoracic or middle ear surgery * severe epilepsy * uncontrollable high fever * pregnancy

Keywords: hbot diabetic foot ulcer hyperbaric oxygen therapy dfu peripheral arterial disease
teas-induced analgesia: dual vs single acupoints

Conditions: Postoperative; Acute Pain; Chronic Pain

Summary: the purpose of this study is to evaluate the effects of transcutaneous electric acupoint stimulation(teas) at single acupoint or dual acupoints on opioid consumption and postoperative pain in patients undergoing radical mastectomy


Eligibility criteria:
inclusion criteria: * patients aged from 18 to 65 yrs * body mass index (bmi) of 18 to 30 kg/m2 * elective radical mastectomy under general anesthesia exclusion criteria: * contradictions to electric stimulation * difficulties in communication * histories of general anesthesia, drug or alcohol abuse or addiction * cardiac dysfunction or severe hypertension, confirmed hepatic dysfunction and renal impairment * participants recruited into other clinical trials during last three months

Keywords: mastectomy transcutaneous electrical acupoint stimulation acute pain chronic pain
short-course radiotherapy based tnt combined with pd-1 inhibitor for locally advanced rectal cancer

Conditions: Locally Advanced Rectal Cancer

Summary: torch is a prospective, multicentre, randomized phase ii trial. 130 larc (t3-4/n+m0, distance from anal verge ≤12cm) patients will be treated with total neoadjuvant therapy (tnt) and assigned to group a and group b. group a receives scrt (25gy/5fx) followed by 6 cycles of toripalimab combined with capox (toricapox). group b receives 2 cycles of toricapox followed by scrt and 4 cycles of toricapox. tme surgery is scheduled after tnt while a watch and wait (w\&w) option can be applied to patients achieving clinical complete response (ccr). the primary endpoint is complete response (cr, pathological complete response \[pcr\] plus ccr) rate. the secondary endpoints include the grade 3-4 acute adverse effects (ae) rate, 3-year dfs rate, etc.


Eligibility criteria:
inclusion criteria: 1. pathological confrmed adenocarcinoma 2. clinical stage t3-4 and/or n+ 3. the distance from anal verge ≤12 cm 4. without distance metastases 5. age 18-70 years old, female and male 6. kps \> =70 7. baseline blood and biochemical indicators meet the following criteria: neutrophils≥1.5×10\^9/l, hb≥90 g/l, plt≥100×10\^9/l, alt/ast≤2.5 uln, cr≤1 uln 8. with good compliance and signed the consent form exclusion criteria: 1. pregnancy or breast-feeding women 2. known history of other malignancies within 5 years 3. known history of previous anti-tumor treatment, including radiotherapy, chemotherapy, immune checkpoint inhibitors, t cell-related therapy, etc 4. known history of severe neurological or mental illness (such as schizophrenia, dementia or epilepsy) 5. current severe cardiac disease (cardiac dysfunction and arrhythmia), renal dysfunction and liver dysfunction 6. acute cardiac infarction or cerebral ischemic stroke occurred within 6 months before recruitment 7. uncontrolled infection which needs systemic therapy 8. active autoimmune disease or immunodefciencies, known history of organ transplantation or systematic use of immunosuppressive agents 9. known history of human immunodefciency virus (hiv) infection (i.e., hiv 1 to 2 antibody positive), active syphilis infection, active pulmonary tuberculosis infection 10. active hepatitis b virus (hbv) or hepatitis c virus (hcv) infection at screening (i.e., hbsag positive or hbv dna positive, hcv rna positive if anti-hcv antibody testing positive) 11. allergic to any component of the therapy
study of the antipodal capsular fold and its potential role in antero-inferior glenohumeral instability

Conditions: Shoulder Capsulitis

Summary: in schoulders instabilty, the soft tissue has not been the subject of histological studies, as has the "bare area" or zone devoid of cartilage, the exact role of which in glenohumeral biomechanics is unknown. this research is based on the hypothesis that the antipodal lesions are constant, underestimated and that an architectural disorganization at the capsulo-ligament level could contribute to the instability of the shoulder. the aim of this study is therefore to better characterize these lesions which could be the subject of a complementary stabilization procedure even in the absence of a humeral notch

surgery for unstable shoulders sometimes involves repairing lesions that promote instability. these lesions are identified on imaging before surgery and then during the operation, but they are macroscopically inconsistent on genuine unstable shoulders. while the importance of posterior capsuloligamentous structures (soft tissue) in antero-inferior stability has been the subject of biomechanical studies, the soft tissue has not been the subject of histological studies, as has the "bare area" or zone devoid of cartilage, the exact role of which in glenohumeral biomechanics is unknown. however, this research is based on the hypothesis that the antipodal lesions are constant, underestimated and that an architectural disorganization at the capsulo-ligament level could contribute to the instability of the shoulder. the aim of this study is therefore to better characterize these lesions which could be the subject of a complementary stabilization procedure even in the absence of a humeral notch.

Eligibility criteria:
inclusion criteria: instability group * patient, male or female, over 18 years old and up to 40 years old * patient operated for antero-inferior shoulder instability * subject affiliated or beneficiary of a social security scheme * patient having signed the free and informed consent comparativ group * patient, male or female, over 18 years old and up to 40 years old * patient operated for a reason other than unstable shoulder * subject affiliated or beneficiary of a social security scheme * patient having signed the free and informed cons exclusion criteria: * history of surgery on the affected shoulder * capsuloligamentous disease (ehler danlos) * history of instability (dislocation, subluxation) in witnesses * patient participating in another clinical study * protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision; * pregnant, breastfeeding or parturient woman; * patient hospitalized without consent.
institut paoli calmettes myelodysplastic syndromes database

Conditions: Myelodysplastic Syndromes

Summary: database of institut paoli-calmettes patients diagnosed with myelodysplastic syndromes


Eligibility criteria:
inclusion criteria: * patient with a diagnosis of myelodysplastic syndromes exclusion criteria: * none
building resiliency in dyads of patients with an ani admitted to the neuro-icu and their informal caregivers

Conditions: Acute Neurological Injury; Emotional Distress

Summary: the purpose of the present investigation is to test the efficacy of a brief (6 sessions) dyadic (patient and caregiver together) intervention to prevent chronic emotional distress in at risk dyads admitted to a neuroscience intensive care unit with an acute brain injury. through this study, we seek to solve the unmet need of preventing chronic emotional distress in neuroscience intensive care unit (nicu) dyads through a feasible, acceptable and credible program, and ideally improve the recovery trajectory and dyads' overall quality of life.

the goals of this study are to: 1) demonstrate the efficacy of recovering together for improving self-reported emotional distress (primary outcome), and post traumatic stress, mindfulness, coping, social support and other relevant outcomes (secondary outcomes); and 2) assess mechanisms (mediators and moderators) of improvement after intervention. we will enroll and randomly assign 194 at risk dyads (97 per study group) to receive either the active intervention or educational control. the trial is single blinded (assessors, patients and staff). the trial will take place at the massachusetts general hospital nicu using our established methodology successfully implemented during the r21 pilot study. study clinicians will deliver 6, 30 minute sessions of active intervention or educational control (2 at bedside and 4 via live video after discharge) to each patient-caregiver dyad. all participants will complete measures at baseline, after completion of program (6 weeks) and 3 months later. they will also complete measures of emotional distress weekly, as well as measures assessing home practice.

Eligibility criteria:
inclusion criteria: * age 18 or older * english fluency and literacy * patient with an informal caregiver available and willing to participate * hospitalized with any ani within 6 weeks (patient) or informal caregiver of a patient currently admitted with any ani * patient and/or caregiver exhibit emotional distress on screening (using hads d and/or hads a scores \> 7) exclusion criteria: * permanent cognitive impairment (including severe hearing impairment) or aphasia that makes participation impossible * short form of mini-mental state exam (smmse) score \<4 (if smmse \<4, nursing team decides whether or not the patient can meaningfully participate) * glasgow coma scale (gcs) score \<10 * terminal diagnosis * lack of access to internet and/or a device with a camera * current untreated or unstable severe mental health conditions like bipolar disorder, schizophrenia, or active substance use

Keywords: neurological injury emotional distress dyadic intervention
d-dimer assay for the exclusion of intra-atrial thrombus risk before ablation of atrial fibrillation

Conditions: Atrial Fibrillation

Summary: the purpose of this study is to determine whether d-dimer dosage allow to exclude risk of intraatrial thrombus before performing an ablation of atrial fibrillation


Eligibility criteria:
inclusion criteria: * age\> 18 years. * patients hospitalized for ablation of atrial fibrillation or symptomatic left flutter * patient informed of the study exclusion criteria: * age \<18 years. * patients under guardianship * pregnant woman * contraindication to transesophageal echocardiography * transesophageal echocardiography made in another center as the center of ablation * refusal of the patient to participate in the study * patient participating in another interventional study in which an intervention related to biomedical research is performed before the transesophageal echocardiography
incentives for moving

Conditions: Sedentary Lifestyle; Obesity; General Well-being

Summary: employees of blue shield of california (bsc) will be recruited to participate to regularly use walkstations. some participants will be randomly assigned to a "hold out" control condition and the remainder will be assigned to one of two experimental treatments: personal incentive vs. charitable incentive. in the personal incentive condition people will be paid $3 for every completed walkstation session, whereas for participants in the charitable incentive condition $3 will be donated to a specific charity. the incentives will operate for approximately 45 days and then for an additional 45 days participants in the two experimental conditions will have access to the walkstations. participants in the hold out control condition will begin using the walkstations after the initial 90 day period.


Eligibility criteria:
inclusion criteria: * must pass the parq exclusion criteria: * ineligible if person did not pass parq and did not provide doctor's note authorizing their participation.

Keywords: behavioral economics incentives health
ct perfusion imaging in predicting treatment response in patients with non-small cell lung cancer or lung metastases treated with stereotactic ablative radiation therapy

Conditions: Malignant Lung Neoplasm; Metastatic Malignant Neoplasm in the Lung; Non-Small Cell Lung Carcinoma; Stage IV Lung Cancer

Summary: this study assesses computed tomography (ct) perfusion imaging in predicting treatment response in patients with non-small cell lung cancer or tumors that have spread from the primary site (place where it started) to the lungs (metastases) treated with stereotactic ablative radiation therapy. ct perfusion imaging is a special type of ct that uses an injected dye in order to see how blood flow through tissues, including lung tissue. ct perfusion imaging of the lungs may help doctors learn whether perfusion characteristics of lung tumors may be predictive of response to treatment and whether lung perfusion characteristics can be used to follow response to treatment.

primary objectives: i. to assess the feasibility of performing computed tomography (ct) perfusion imaging (ct perfusion imaging) at baseline, within 48 hours post-stereotactic ablative radiation therapy (sabr), and at 2-4 months sabr in patients undergoing sabr for treatment of a lung tumor per standard of care. secondary objectives: 1. to determine the range (variability) of perfusion parameters at baseline, within 48 hours post-sabr, and at 2-4 months post-sabr 2. to assess the change in perfusion parameters at baseline, within 48 hours post-sabr, and at 2-4 months post-sabr 3. to correlate any change in perfusion parameters with circulating-tumor deoxyribonucleic acid (dna) levels at baseline, within 48 hours post-sabr, and at 2-4 months post-sabr 4. to correlate perfusion parameters with tumor response 1 year post-sabr outline: patients receive an infusion of isovue-200 and undergo ct perfusion imaging of the lungs at baseline, within 48 hours of first sabr, and at 2-4 months after completion of sabr. cancer personalized profiling by deep sequencing (capp-seq) will be conducted evaluate circulating-tumor dna levels. perfusion parameters will be correlated with tumor control at 1 year post-sabr, with tumor control defined as no evidence of disease seen at the site of sabr by surveillance imaging at 1 year post-sabr. after completion of treatment, patients are followed up at 2-4 months and then at 1 year.

Eligibility criteria:
inclusion criteria: * patients undergoing sabr for the treatment of a lung tumor, inclusive of non-small cell lung cancer or lung metastases exclusion criteria: * patients who are pregnant or are trying to become pregnant are excluded from this study * patients with renal failure, defined as glomerular filtration rate (gfr) \< 60 at the time of the radiation treatment-planning (rtp) scan, will be excluded
subjective feelings of job stress and frontal activity during verbal fluency test: a near-infrared spectroscopy study

Conditions: Stress

Summary: background and objectives: recently the news of intern doctors' death due to overloaded work or committing suicide has made the authorities concerned put emphasis on the mental health care of medical staffs and related policies of psychological interventions. the prefrontal lobe plays an important role in the working memory, executive function and problem-solving abilities of the brain. currently, no neuroimaging studies investigating the impact of job stress on the prefrontal love functions in intern doctors. functional near-infrared spectroscopy (fnirs) measures the cortical functions of the frontotemporal regions and has been widely used as a biomarker to aid in differential diagnoses in major psychiatric illnesses in japan. the present study will investigate impact of the job stress on brain cortical activity during a verbal fluency test (vft) by using fnirs. materials and methods: a total of 100 participants will be recruited. clinical measurements of mood status by beck's depression inventory and beck's anxiety inventory, as well as job stress by chinese version of the job content questionnaire and the chinese version of copenhagen burnout inventory will be arranged. the relationship between clinical measurements and cortical activity during a vft will be analyzed by pearson's correlation. multiple regression analysis will be applied to investigate the independent contributions of mood status and job stress. expected results and contributions of the study: job stress, depression, and anxiety are significantly negatively correlated with cortical activity of prefrontal regions. the importance of mental health of medical staffs under high job stress should be stressed.

a total of 100 intern doctors will be recruited. the data including chinese version of copenhagen burnout inventory, bdi, bai, average working hours per day, and average sleeping times were acquired. they will undergo nirs investigations to detect frontal activities during performing a verbal fluency test. the correlation between stress parameters and cortical activities were examined.

Eligibility criteria:
inclusion criteria: * medical intern doctors who are willing to participate in the study. exclusion criteria: * with past psychiatric disease * with history substance abuse or dependence * with history neurological disorders or head trauma

Keywords: near infrared spectroscopy nirs intern