Kornimate/medical-research-clean huggingface dataset:
reverse electrical remodeling of native conduction in cardiac resynchronization therapy

Conditions: Heart Failure; Patients Undergoing CRT-D Device Implantation

Summary: cardiac resynchronization therapy with pacemaker alone, or in combination with a cardioverter-defibrillator, prolongs life and decreases risk of heart failure exacerbation in patients with low ejection fraction and wide qrs. some patients achieve decrease in qrs duration 6 months after cardiac resynchronization therapy. such phenomenon is called reverse electrical remodeling of native conduction. retrospective analysis showed that reverse electrical remodeling of the native conduction after at least 6 months of crt is associated with decreased rate of ventricular arrhythmias and better survival. this study is designed to study reverse electrical remodeling prospectively.


Eligibility criteria:
inclusion criteria: * patients undergoing implantation of a crt-d exclusion criteria: * age \< 18 y * pregnancy or planned pregnancy
the role of sulfur amino acids in risk of kwashiorkor

Conditions: Kwashiorkor

Summary: this observational cross-sectional study is investigating if young children in populations with higher prevalence of kwashiorkor malnutrition have lower dietary sulfur amino acid intake than populations with lower prevalence of kwashiorkor, controlling for multiple potential confounding factors. intake is estimated through diet recalls during interviews with a child's caregiver, analysis of urine samples and analysis of food samples for their amino acid profiles.

kwashiorkor is one of two categorizations of severe acute malnutrition, but its etiology remains unclear. although kwashiorkor is found only where diets are low in quality protein, comparisons of total dietary protein of individual children with and without kwashiorkor has been inconclusive. this study aims to compare amino acid profiles of the diets, not just total protein. evidence has shown that children with kwashiorkor consistently have very low circulating levels of sulfur amino acids (cysteine and methionine). typical staple foods in regions with endemic kwashiorkor are generally poor in sulfur amino acids and the signs characterizing kwashiorkor can plausibly be explained by a shortage of sulfur amino acids. in eastern democratic republic of the congo, certain populations have chronically higher prevalence of kwashiorkor than neighboring populations with similar livelihoods, religion, environment, language and ethnicity. this study will compare these two populations to understand what differences between them may explain the difference in prevalence.

Eligibility criteria:
inclusion criteria: * resident of the selected population * in the appropriate age range exclusion criteria: * caregiver reports the child has an illness that has required treatment for at least 6 months

Keywords: sulfur amino acid
ultrasound for diagnosing costochondral joint separation

Conditions: Rib Fractures; Thoracic Injuries

Summary: this study aims to evaluate the diagnostic effectiveness of ultrasound in detecting costochondral joint separation in patients with blunt thoracic trauma. by comparing ultrasound findings to computed tomography (ct) results, the study seeks to determine the sensitivity, specificity, and overall accuracy of ultrasound as a diagnostic tool. the results will help improve the diagnosis and management of costochondral injuries while minimizing radiation exposure. the study is a prospective, interventional trial conducted at ondokuz mayıs university faculty of medicine.

this study investigates the diagnostic effectiveness of ultrasound (usg) in identifying costochondral joint separation in patients presenting with blunt thoracic trauma. the study aims to assess usg's sensitivity, specificity, and accuracy compared to computed tomography (ct), which is considered the gold standard. costochondral separation, a condition where the connection between the rib and its cartilage is disrupted, is often challenging to diagnose with traditional imaging techniques. ultrasound offers a non-invasive, portable, and radiation-free alternative, potentially allowing for rapid diagnosis and improved patient outcomes. participants will undergo both usg and ct imaging as part of the diagnostic protocol. the primary outcome measure will be the diagnostic accuracy of usg in detecting costochondral joint separation. secondary outcomes include time to diagnosis, patient comfort, and correlation of ultrasound findings with clinical presentations. the study will be conducted prospectively at ondokuz mayıs university faculty of medicine from march 2025 to march 2027, involving a sample size of 51 patients based on power analysis. data collected will include demographic information, trauma specifics, imaging findings, and clinical outcomes. the results are expected to contribute significantly to the field of thoracic trauma care by demonstrating the utility of ultrasound in settings where quick and accurate diagnosis is critical.

Eligibility criteria:
inclusion criteria: * patients aged 18 to 80 years * patients with blunt thoracic trauma * patients suspected of having costochondral joint separation * patients who provide consent for ultrasound and ct imaging exclusion criteria: * patients under 18 or over 80 years of age * patients with penetrating thoracic trauma * patients with subcutaneous emphysema that prevents ultrasound evaluation * patients allergic to ultrasound gel * pregnant patients (as ct imaging is contraindicated) * patients unable to undergo ct imaging * patients who refuse to participate in the study * obese patients (body mass index \>30), as ultrasound evaluation may be challenging

Keywords: costochondral joint separation ultrasound blunt thoracic trauma thoracic surgery computed tomography
onabotulinumtoxina for the treatment of urinary incontinence due to overactive bladder in pediatric patients (12 to 17)

Conditions: Urinary Incontinence; Urinary Bladder; Overactive

Summary: this was a multicenter, randomized, double-blind, parallel-group, multiple-dose study to evaluate the efficacy and safety of botox in adolescents with urinary incontinence due to overactive bladder (oab) with inadequate management with anticholinergic therapy. participants were randomized in a 1:1:1 ratio to receive a single tx of 25 u, 50 u, or 100 u botox (not to exceed 6 u/kg) on day 1, were seen after each treatment at weeks 2, 6, and 12 post-treatment, and thereafter at alternating telephone and clinic visits every 6 weeks until they qualified for further retreatment/exited the study. participants could receive multiple treatments dependent upon the number and timing of patient requests/qualification for retreatment. at each retreatment the investigator could keep the dose the same or increase it one dose level in a blinded fashion. participants exited the study once 96 weeks have elapsed since entry on day 1 and at least 12 weeks follow-up since their last study treatment had occurred.


Eligibility criteria:
inclusion criteria: * symptoms of overactive bladder (oab) (frequency/urgency) with urinary incontinence for at least 6 months * oab symptoms not adequately managed by 1 or more anticholinergic agents exclusion criteria * oab caused by a neurological condition * use of anticholinergics or other medications to treat oab symptoms within 7 days * current use of indwelling catheter or clean intermittent catheterization to empty the bladder * previous or current use of botulinum toxin therapy of any serotype for any urological condition, or treatment with botulinum toxin of any serotype within 3 months for any other condition or use * myasthenia gravis, eaton-lambert syndrome, or amyotrophic lateral sclerosis
infections related central venous catheters

Conditions: SIRS

Summary: the purpose of this study is to clarify the relationship between sirs (systemic inflammatory response syndrome) and the infection associated with the use of central venous catheters at critical care center in national defense medical college, japan.

the doctor would remove the inserted catheter from the patient, if the patient shows sirs. at the same time, the tip of used catheter and blood from the patient are checked whether the pathogenic bacteria exists or not by general bacterial protocol and blood culture test on a routine application. unfortunately, these tests not always clarified their cause of sirs. therefore we conduct this investigation to establish the useful protocol for pathogenic bacteria. we check the pathogenic bacteria not only tip but through the whole catheter in central venous catheter using general bacterial protocol and sem observation. additionally, we compared that sputum, urine, skin and blood from the patient for bacteria check.

Eligibility criteria:
inclusion criteria: * a patient has been inserted with central venous line over 24 hours.

Keywords: central venous catheter nosocomial infection
upper limit for tsh of first and second trimester pregnancy in turkey

Conditions: Thyroid; Thyroid Dysfunction; Hypothyroidism; Pregnancy Early

Summary: physiological changes necessitate the use of pregnancy-specific reference ranges for tsh and ft4 to diagnose thyroid dysfunction during pregnancy. although many centers use fixed upper limits for tsh of 2.5 or 3.0 mu/l, this may lead to overdiagnosis or even overtreatment. the new guidelines of the american thyroid association have considerably changed recommendations regarding thyroid function reference ranges in pregnancy accordingly. any hospital or physician that is still using the 2.5 or 3.0 mu/l cut-off for tsh during pregnancy should evaluate their own lab-specific cut-offs. the investigator's objective is to establish a rational reference range of serum tsh for diagnosis of subclinical hypothyroidism in the first and second trimester of pregnant women in west black sea region in turkey.

serum thyroid function tests (including t3, t4, tsh, anti-tpo) will be obtained from the singleton pregnancies in first and second trimester to determine the local specific normal ranges.

Eligibility criteria:
inclusion criteria: * singleton pregnancy * free of pre-existing thyroid disease * that do not use thyroid interfering medication * that did not undergo ivf treatment * tpoab negative exclusion criteria: * adolescent pregnancy

Keywords: tsh
pediatric open-label extension study of etanercept in patients with plaque psoriasis

Conditions: Pediatric Plaque Psoriasis

Summary: the purpose of this study is to evaluate the long-term safety and efficacy of etanercept in pediatric patients with moderate to severe psoriasis.

this study was a multicenter, open-label extension study for pediatric patients who participated in study 20030211 (nct00078819).

Eligibility criteria:
inclusion criteria: * enrollment on previous amgen study 20030211 (nct00078819) exclusion criteria: * serious or clinically significant adverse event on amgen study 20030211 related to etanercept

Keywords: immunex amgen pediatric, plaque psoriasis clinical trial
clonidine versus adenosine to treat neuropathic pain

Conditions: Pain

Summary: the purpose of this study is to determine the effects of clonidine and adenosine on nerve pain.

this study is part of a pain center grant that focuses on how pain, especially chronic neuropathic pain, alters the response to traditional and non-traditional analgesics (pain medications). clonidine-a drug commonly used to treat high blood pressure-has been shown to effectively treat neuropathic pain, is fda-approved for administration via epidural (an injection given in the lower back), and is the third most commonly prescribed drug for chronic intrathecal (an injection into the cerebrospinal fluid) use in people with chronic pain. adenosine-a drug commonly administered intravenously (into a vein) to treat certain types of abnormal heart rhythms-has been found to reduce areas of allodynia (pain caused by a stimulus that does not normally cause pain) after intrathecal, but not intravenous administration in people with neuropathic pain. intrathecal clonidine relieves pain by actions on a2-adrenoceptors in the spinal cord, whereas adenosine relieves pain by actions on a1 adenosine receptors. researchers believe that intrathecal adenosine and clonidine may prove to be excellent painkillers for nerve pain. therefore, the goal of this study is to determine the effects of clonidine and adenosine on nerve pain. after initial screening, baseline measurements, and training to learn to estimate pain accurately using thermal heat testing, a sample of spinal fluid will be taken from each participant. participants then will be randomly chosen to receive either clonidine, adenosine, or placebo. after receiving the study medication, participants will be monitored, with their vital signs checked at 30, 60, 120, 180, and 240 minutes. duration of the study for participants is 2 weeks, and includes two visits to the research center, each lasting approximately 6 hours.

Eligibility criteria:
inclusion criteria: * patients with complex regional pain syndrome (crps), type i involving a lower extremity exclusion criteria: * pregnancy * allergy to clonidine * currently taking clonidine or other direct a2-adrenergic agonists, or taking cholinesterase inhibitors * patients with any serious or unstable medical problems (heart, lung, liver, kidney, or nervous system disease)

Keywords: pain chronic pain clonidine adenosine complex regional pain syndrome crps a2-adrenergic agonists alpha2-adrenergic agonists
choice to avoid or resist

Conditions: Overweight and Obesity

Summary: this trials will formally test whether participants' active choice of self-regulatory strategies (avoid or resist) leads to greater adherence to weight management strategies by comparing the choice arms to the randomized arms of the parent intervention, avoid/resist (irb study00001652: avoid-resist).

since we initiated recruitment for the avoid/resist trial (irb study00001652: avoid-resist), we have noted that some participants have a strong initial inclination for one of the self-regulatory strategies. some individuals have clearly expressed which strategy they believed would work for them, while others have voiced dislike or skepticism for an assigned intervention component. while attrition in the last 18 months (12.5%) is comparable to trials of similar size and scope, over 56% (n=18) of withdrawals were explicitly (n=3) or tangentially (n=15) related to intervention assignment. this pilot study (choice) seeks to leverage our ongoing r01 to test whether participants' active choice of behavior change pathways and strategies leads to better adherence, retention, and engagement. consistent with ongoing procedures, women, and men with overweight or obesity (bmi between 25-45 kg/m2) will be enrolled in the ww digital program for 12 months. r01 participants will continue to be randomized to one of the 4 study arms: (1) ww alone, (2) ww + avoid, (3) ww + resist, (4) ww + avoid + resist. choice participants will be asked to choose which self-regulatory strategy (avoid or resist) they want to receive to promote behavior change consistent with ww recommendations.

Eligibility criteria:
inclusion criteria: * age 18 years or older * bmi between 25-45 kg/m2 * read, write, and speak english with acceptable visual acuity exclusion criteria: * currently enrolled in weight loss interventions or undergoing bariatric surgery * pregnant women * individuals for whom weight loss may be contraindicated (e.g., unstable coronary artery disease, end-stage disease, active cancer treatment, uncontrolled insulin-dependent diabetes, portal hypertension, drug/alcohol abuse) * individuals who have pacemakers or other electronic medical device implantations * individuals with severe cognitive delays or visual/hearing impairment * individuals who are unable or unwilling to complete the study assessments / measurements * individuals currently subscribed to a meal delivery service who are unwilling to pause their subscription for the duration of the study
investigating targetable metabolic pathways sustaining pancreatic cancer

Conditions: Pancreatic Ductal Adenocarcinoma

Summary: this clinical trial investigates the nutrients pancreatic cancers depend on in which to survive and the processes these tumors use (metabolism) to obtain these nutrients. giving u-13c-glucose during surgery may allow doctors to trace the metabolic activity of pancreatic cancer in research experiments done in the laboratory. these experiments may help researchers understand how cancer cells manage their nutrients when compared to normal pancreatic cells.

primary objective: i. to describe and discover new insights into the glucose, tricarboxylic acid (tca) cycle, amino acid, and lipid metabolic dependencies of pancreatic ductal adenocarcinoma (pdac) via liquid chromatography-mass spectrometry (lc-ms) analysis of in vivo uniformly-labeled \[13c\]glucose (u-13c-glucose) labeled pancreatic cancer biopsies. outline: patients receive uniformly-labeled \[13c\]glucose intravenously (iv) over 10 minutes and then over up to 120 minutes until time of biopsy. patients then undergo surgery and biopsy per standard of care.

Eligibility criteria:
inclusion criteria: * male or female patients \>= 18 years of age * pancreatic adenocarcinoma patients, previously diagnosed by biopsy, who are candidates for intended curative resection either with or without neoadjuvant chemotherapy * willing to undergo mandatory intraoperative small excisional and core biopsies (4-6 passes) of tumor and normal tissue for research purposes at the time of proposed pancreatectomy * 16 patients will be enrolled including 8 with no prior treatment and 8 treated with at least 3 months of neoadjuvant chemotherapy * all patients must be able to understand the investigational nature of the study and give written informed consent prior to study entry exclusion criteria: * patients receiving any anti-cancer therapy (chemotherapy, immunotherapy, and/or biologic therapy) for 8 patients; the other 8 patients will be treated with neoadjuvant chemotherapy but no radiation, biologic or immunotherapy prior to surgery * is currently enrolled, or will enroll in, a different clinical study in which investigational therapeutic procedures are performed or investigational therapies are administered while participating in this study * concomitant active malignancy * is of child-bearing potential who has not had a recent negative pregnancy test done outside of this clinical trial (i.e., as part of standard preparation for diagnosis and treatment for her cancer)
multicentre study comparing indwelling pleural catheter with talc pleurodesis for malignant pleural effusion management

Conditions: Pleural Effusion, Malignant

Summary: malignant pleural effusion (mpe) accounts for 50% of all pleural effusions and affects about 300,000 patients annually (uk and usa). lung and breast cancers account for majority of malignant pleural effusions; 1 in 3 breast cancer, 1 in 4 lung cancer as well as \> 90% of patients with mesothelioma develop pleural effusions. breathlessness from mpe is disabling and impairs quality of life. median survival ranges between 4-6 months. although thoracentesis provides effective symptom relief, most effusions recur and pleurodesis is the standard of care. pleurodesis can be performed via chest tube or applied during pleuroscopy, and talc is the most effective agent. for successful pleurodesis to occur the underlying lung must expand after fluid drainage and trapped lung due to metastatic disease occurs up to 30%. symptomatic patients require hospitalization for these procedures which are likely to fail if trapped lungs are encountered, and pose significant burden to health services. tunneled indwelling pleural catheter (ipc) is emerging as a viable alternative which provides access to the pleural space for fluid drainage when breathlessness arise. ipc can be performed at ambulatory setting without hospital admission. case series have demonstrated long-term safety of ipc even in patients undergoing chemotherapy with acceptable complication rates. by keeping the pleural cavity free of fluid, ipc has led to spontaneous pleurodesis in 50% of patients, which allows its removal. presently ipc is indicated for trapped lung or when talc pleurodesis has failed. a randomised comparative trial with talc pleurodesis is necessary to determine role of ipc as first-line therapy of mpe, if ipc leads to reduction in hospitalizations, adverse events and healthcare costs, and if it improves quality of life. the multicenter trial randomizes symptomatic patients 1:1 to ipc or talc pleurodesis, and endpoints include hospitalization days till death or end of study, adverse events, quality of life, and healthcare costs.


Eligibility criteria:
inclusion criteria: * symptomatic malignant pleural effusion requiring intervention exclusion criteria: * \<18 years of age * pregnant or lactating patients * expected survival \<3 months * chylothorax * previous attempted pleurodesis * pleural infection * leukocytopaenia (\<1.0 x 10\^9/l) * uncorrectable bleeding diathesis * inability to give informed consent or comply with the protocol
seroprevalence hepatitis e infection in healthy blood donors

Conditions: Hepatitis E

Summary: this is a hev seroprevalence in the health donors in the canton ticino study. the pre-donation sampling pouch of each blood donor coming form the cantone ticino region will be collected and tested for hev serology (igm and igg).

pre-donation sampling pouch of fresh and stored frozen plasma collected within the last 5 years will be tested for hev igg serology at the national reference laboratory of the blood transfusion services src in berne collected data will be used to determine hev seroprevalence, actual and in the last 5 years, in the canton ticino and to investigate trend and pattern of the hev infection (seroprevalence by different regional areas, comparison with national hev data, and correlation with age, sex and place of residence).

Eligibility criteria:
inclusion criteria: * healthy and voluntary blood donors * subjects living in the canton ticino * inclusion criteria for blood donation * signed informed consent of the stcrs si for blood donation exclusion criteria: * exclusion criteria for blood donation
preventing weight gain in african american reproductive-aged women

Conditions: Weight Gain; Women's Health; Obesity

Summary: the purpose of this research study is to evaluate the effect of a facebook-delivered weight-gain prevention program versus a facebook-delivered program with general women's health information.

weight gain is an important health concern, and disparities in the prevalence of obesity between african american and white women increase throughout the reproductive period. this study is a randomized, controlled trial testing the feasibility and acceptability of a peer-coach-administered, facebook-delivered intervention to prevent weight gain in overweight and obese african american women. study visits lasting approximately 1 hour will occur at baseline, post-intervention, and 1-month follow-up, to assess effectiveness and acceptability. the core intervention will occur over a 4-week period. educational content in both the weight-gain prevention program and women's health program will be delivered via facebook, with new content posted each weekday related to that week's topics. the peer coaches may contact participants via private messaging, when needed, to provide support and encourage engagement. if successful, this intervention could be easily disseminated to populations in under-served and community settings.

Eligibility criteria:
inclusion criteria: * african american * has facebook account and uses it, on average, at least once a day * body mass index (bmi) of 25-45 * has access to the internet * able to consent in english exclusion criteria: * currently pregnant or breastfeeding, recently postpartum (within 6 weeks) * diagnosis of diabetes mellitus * history of contraindicated medical conditions or conditions that can affect weight * current use of certain medications

Keywords: facebook weight gain prevention women's health online weight gain weight loss female contraception obesity body weight internet