Kornimate/medical-research-clean huggingface dataset:
acupuncture in treating hot flashes in patients with prostate cancer

Conditions: Fatigue; Hot Flashes; Prostate Cancer

Summary: rationale: acupuncture may help relieve hot flashes in patients with prostate cancer. purpose: this clinical trial is studying how well acupuncture works in treating hot flashes in patients with prostate cancer who are undergoing androgen deprivation.

objectives: * determine the impact of acupuncture therapy on the frequency and intensity of hot flashes and the quality of life of patients with prostate cancer undergoing androgen deprivation. * determine if blood serotonin and urinary 5-hiaa are increased in patients treated with acupuncture. * determine if plasma calcitonin gene-related peptide and mhpg are reduced in patients with hot flashes due to androgen deprivation treated with acupuncture. * determine the ability of tongue diagnosis, a traditional chinese clinical assessment method, to predict clinical and biological changes in these patients. * determine the effect of acupuncture on insomnia and loss of vitality caused by hot flashes in these patients. outline: patients undergo acupuncture for 30 minutes twice weekly for 4 weeks and then once weekly for an additional 6 weeks. quality of life is assessed at baseline, at weeks 2, 4, 6, and 10, and then at 6 weeks after completion of study treatment. after completion of study treatment, patients are followed at 6 weeks. projected accrual: a total of 25 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * confirmed diagnosis of prostate cancer * hot flash score ≥ 4 per day * prior or concurrent treatment with 1 of the following : * bilateral orchiectomy * gonadotropin releasing-hormone (gnrh) agonist or antagonist therapy * antiandrogen therapy patient characteristics: performance status * not specified life expectancy * not specified hematopoietic * not specified hepatic * not specified renal * not specified other * no mental impairment prior concurrent therapy: chemotherapy * no concurrent chemotherapy endocrine therapy * see disease characteristics * more than 4 weeks since prior estrogen or progestational drugs surgery * see disease characteristics * no prior placement of a pacemaker or other implantable electrical device other * more than 4 weeks since prior gabapentin * no concurrent antidepressant drugs

Keywords: fatigue recurrent prostate cancer stage ii prostate cancer stage iii prostate cancer stage iv prostate cancer hot flashes
an osteopathic assessment of lower extremity somatic dysfunction in runners

Conditions: Somatic Dysfunction of Sacral Region; Somatic Dysfunction of Both Sacroiliac Joints; Somatic Dysfunction of Bilateral Lower Extremities

Summary: runners often experience acute/chronic pain due to pre-existing structural somatic dysfunction and/or acquired various overuse injuries of the lower extremity, specifically affecting the ligaments, tendons, muscles and bones. common structural and function dysfunctions include but are not limited to patellofemoral pain syndrome (pfps), achilles tendonitis, iliotibial band syndrome (itbs), ligamentous and muscle tears, muscle sprains/strains, stress fractures, pes planus, plantar fasciitis, and shin splints. the purpose of this study is to assess the correlation between acute and chronic pain, overuse injuries, and observational and palpatory findings upon evaluation. with an understanding of the common trends of somatic dysfunctions and etiology of the pain/injury, modified regimen/routine and improved treatment plans can be developed and recommended for runners to better rehabilitate, minimize relapse and reduce compensatory injuries. no medical or osteopathic treatment will be provided.


Eligibility criteria:
inclusion criteria: * self-proclaimed runners that run at least 1 mile per week consistently * minimum 18 years old exclusion criteria: * non-runners * inconsistent runners, do not log at least 1 mile weekly

Keywords: somatic dysfunction runners osteopathic osteopathic assessment lower extremity lower extremity somatic dysfunction running injury
recurrence of bladder cancer after transurethral resection with hexvix

Conditions: Bladder Cancer

Summary: this is a randomised, comparative, multicentre study to determine if the early recurrence rate of intermediate-risk bladder cancer is similar in subjects treated with multiple instillations of mitomycin c after resection conducted under white light cystoscopy (group a) and subjects treated with 1 instillation of mitomycin c after resection conducted under white light and blue light cystoscopy (group b).


Eligibility criteria:
inclusion criteria: * the subject is not of childbearing potential and signed informed consent. * subject with 1 or more primary bladder tumours, confirmed on an outpatient cystoscopy or subjects with 1 or more recurrent bladder tumours appearing within 12 months of removal of a previous bladder tumour, confirmed on an outpatient cystoscopy. exclusion criteria: * the subject was previously included in this study. * the subject has a history/is suspected to have tag3 or greater than or equal to t1 tumours or carcinoma in situ (cis). * the subject is suspected to have single primary or single recurrent tag1 tumours when recurrence occurs more than 1 year after initial diagnosis or previous recurrence. * the subject has known tumours in the prostatic urethra, distal urethra, or upper urinary tract. * the subject has gross haematuria. * the subject has a history of porphyria.
long term survivors in ovarian cancer

Conditions: Ovarian Cancer

Summary: in this study the investigators would like to explore the patient and tumour characteristics of long-term survivors of ovarian cancer (\>10 years). indentifiying the characteristics of long-term survivors not only helps find prognostic factors for survival but may aid in generating hypotheses for novel therapeutic strategies.


Eligibility criteria:
inclusion criteria: to achieve a large enough study population of approximately 80 subjects, patients surviving \>10 years after treatment for stage iiic/iv epithelial ovarian cancer in the past 25 years will be included from five hospitals. patients were diagnosed between 1979 and 2006 and treated in the north of the netherlands. a list of subjects fitting these inclusion criteria will be extracted from the national cancer registry (nkr).
the efficacy of lpprp in the treatment of chondromalacia patella

Conditions: Chondromalacia Patellae

Summary: chondromalacia patella(cp) is a common cause of anterior knee pain in the population under 50 years of age. cp is characterized by softening or varying degrees of damage to the patellar cartilage. the positive effects of leukocyte poor-platelet rich plasma (leukocyte poor-platelet rich plasma, lp-prp) on cartilage repair and degenerative findings are known. however, there is no randomized controlled study on this subject in cp. the aim of this study is to investigate the effect of lp-prp on pain, function, walking distance and magnetic resonance imaging (mri) findings in cp patients.the study is the first to investigate the effect of lp-prp on cartilage measurement with mri in chondromalasia patella. patients with anterior knee pain who applied to the physical therapy and rehabilitation outpatient clinic of kayseri city hospital, patients with chondromalacia patella in mri will be included in the study. a total of 40 patients will be randomized into 2 groups. the exercise program will be applied to both groups as a home program for 4 weeks.

a randomized, prospective, controlled study included 28 patients with mri stage 2 and above chondromalasia patella findings. the patients were randomized into 2 groups, group 1 (the group in which 2 doses of suprapatellar bursa were injected with 2 doses of 3 cc lp-prp at 1-week intervals and a 4-week home exercise program was given) and group 2 (the control group, the group given a 4-week home exercise program). patients were tested on the visual analogue scale (vas) day, night and motion, western ontario mcmaster universities osteoarthritis index (womac), 6-minute walk test (6mwt) at baseline,1st week, 4th week and 12th week and cartilage thickness, including defective cartilage thickness, and chondromalasia patella outerbridge staging were evaluated on mri at baseline and 12th week. womac value was taken as the primary outcome measure and mri cartilage values were taken as the secondary outcome measure. clinic responsible for research: physical therapy and rehabilitation clinic of kayseri city hospital

Eligibility criteria:
inclusion criteria: * chondromalasia patella stage 2 and above in mri requested from patients with chronic pain around the patella, who have increased pain in at least one of the activities that carry loads while the knee is flexed (squatting, stepping, running, jumping, jumping) after physical examination and clinical evaluation * patients with vas 3 and above * patients over 18 years of age * patients without any deformity in the lower extremity exclusion criteria: * coagulopathy and/or thrombocytopenia * cardiovascular instability or severe disease condition * presence of systemic infection or malignancy * pregnancy * intra-articular injection in the last 6 months * stage 3 and above meniscopathy in mri * evidence or suspicion of rupture of the anterior cruciate ligament on mri

Keywords: chondromalacia patellae leukocyte-poor platelet-rich plasma magnetic resonance imaging
adjuntive probiotic therapy in treating urinary tract infections in spinal cord injury

Conditions: Spinal Cord Injury; Urinary Tract Infections

Summary: we hypothesize that probiotic lactobacillus can augment antibiotic treatment of symptomatic urinary tract infection (uti) in spinal cord injured patients, and also increase the time to the next episode of uti.

subjects will be recruited from the outpatient population and 'alumni' of the regional sci rehabilitation programs in london (parkwood hospital/st joseph's health care) and hamilton (hamilton health sciences centre) ontario. community living paraplegic and tetraplegic men and women (18 years and above) who present to their family physician or specialist with symptomatic uti will be prescribed an antibiotic treatment for up to 14 days (using the drug of choice i.e. which the treating physician deems appropriate) and randomized to also receive by mouth two capsules containing placebo or probiotic lactobacillus rhamnosus gr-1 and l. reuteri rc-14 daily.

Eligibility criteria:
inclusion criteria: * spinal cord injury * uti * \> 18years * male and females * prescribed antibiotics exclusion criteria: * patients who are participating in another clinical study involving pharmaceutical products. * patients who are participating in other urology clinical study. * patients taking yogurt containing probiotic lactobacilli during the period of the study. * females who are pregnant and/or planning to get pregnant during the study period

Keywords: spinal cord injury urinary tract infection probiotics lactobacilli
impact of lower body weight support treadmill on cardiopulmonary exercise capacity and trainability

Conditions: Healthy Volunteers

Summary: the alterg®-anti-gravity treadmill provides lower body weight support which enables individuals to exercise without feeling their full body weight. how this body weight support influences cardiovascular, respiratory, vascular and metabolic parameters is currently unclear. further, whether body weight support influences the trainability in response to moderate continuous exercise is unknown. this investigation has two main goals. first, we explore the direct influence of lower body weight support on cardiometabolic parameters during maximal exercise testing. second, we aim to compare changes in cardiorespiratory fitness in response to a structured exercise protocol using moderate intensity with and without lower body weight support.


Eligibility criteria:
inclusion criteria: * maximal oxygen consumption below age-sex specific standard exclusion criteria: * acute infection within the last four weeks * anemia (males: hb \< 8.1 mmol/l; females hb \< 7.4 mmol/l) * previous reports of myo-, endo, or pericarditis * previous stroke or acute myocardial infarction * heart failure (nyha \> 1) * aortic valve stenosis * congenital heart disease * cardiomyopathy * severe left ventricular hypertrophy * cardiac arrythmias * hypertension * diabetes * bmi \> 35 * cancer * pregnancy * aneurysm of aorta or cerebral arteries
internet-based interacting together everyday, recovery after childhood tbi (i-interact)--rrtc

Conditions: Traumatic Brain Injury

Summary: the purpose of this study is to test two on-line interventions for families of young children who have experienced moderate or severe traumatic brain injury (tbi). this project builds upon the investigators' previous research by modifying the online intervention content to address the needs of young children with tbi. the goal of this project is to develop an intervention that will encourage positive parenting behaviors, improve child behaviors, and reduce parent distress and burden following tbi. the investigators hypothesize that the intervention groups will exhibit more effective parenting skills as well as better child functioning and lower levels of parental distress at follow-up than will the active comparison group.

the investigators will conduct a multi-site randomized controlled trial (rct) comparing the efficacy of 7-week internet-based interacting together everyday, recovery after childhood traumatic brain injury express (i-interact express) and 24-week long web-based positive parenting skills programs internet-based interacting together everyday, recovery after childhood traumatic brain injury (i-interact) to an internet resource group (irc) involving access to internet resources and education about brain injury. the project builds upon the feasibility and efficacy findings from an ongoing randomized trial comparing the efficacy of a 24-week positive parenting skills program to access to internet resources. however, it differs in size and scope by including multiple sites, and by including an abbreviated parenting skills training arm in response to family feedback that the existing 24-week intervention was excessively long, resulting in adherence difficulties. the investigators anticipate that the improvements in parenting skills and psychological functioning will translate into improved parent-child relationships and reductions in child behavior problems. over time, such improvements in child and parent functioning should contribute to academic and social success and more successful community integration.

Eligibility criteria:
inclusion criteria: * moderate to severe tbi that occurred within the last 24 months * overnight hospital stay * english-speaking * parent must be willing to provide informed consent exclusion criteria: * child does not live with parents or guardian * child or parent has history of hospitalization for psychiatric problem * child suffered a non-blunt injury (e.g., projectile wound, stroke, drowning, or other form of asphyxiation) * diagnosed with moderate or severe mental retardation, autism, or a significant developmental disability

Keywords: tbi intracranial edema brain edema craniocerebral trauma head injury brain hemorrhage, traumatic subdural hematoma brain concussion head injuries, closed epidural hematoma extra-axial hemorrhage cortical contusion additional relevant mesh terms: nervous system diseases wounds and injuries disorders of environmental origin central nervous system diseases trauma, nervous system brain diseases brain injuries
the effects of intrauterine interventions during placenta removal on pain, perception of traumatic birth, and early postpartum health indicators in women

Conditions: Placenta, Retained

Summary: a prospective cohort study was conducted with 64 women who had vaginal deliveries at adana city training and research hospital between october 2023 and may 2024. women who received intrauterine interventions during the third stage of labor formed the case group (n=32), and those who did not formed the control group (n=32). data were collected using the pregnant information form, labor observation form, early postpartum period follow-up form, visual analog scale (vas), and traumatic birth perception scale (tbps). findings were determined through regular monitoring and follow-ups during the first 24 hours postpartum.


Eligibility criteria:
inclusion criteria: the inclusion criteria required participants to be 18 years or older, to have delivered at term (38-40 weeks), to have had a vaginal delivery, and to have a singleton pregnancy. additionally, participants must not have been using analgesic medications, must not have had hypertension or preeclampsia, and must not have experienced atony in a previous pregnancy. participants also needed to be free from infections, placental anomalies, genital lesions, or coagulation disorders, and they had to agree to participate in the study exclusion criteria: exclusion criteria included women who experienced a difficult labor or whose delivery involved the use of forceps or vacuum assistance.
vasopressin to prevent hypotension during beach chair surgery

Conditions: Rotator Cuff Tear Arthropathy

Summary: patients undergoing surgery in beach chair position (bcp) are at risk for cerebral ischaemia. the impacts of arginine vasopressin (avp) on haemodynamics and cerebral oxygenation are evaluated during surgery in bcp.

patients undergoing shoulder surgery in bcp under general anaesthesia are randomly allocated to receive i.v. normal saline (control group) or avp 0.05 or 0.07 u kg-1 (avp group, n = 15 each) 2 min before moving into bcp. mean arterial pressure (map), heart rate (hr), jugular venous bulb oxygen saturation (sjvo2) and regional cerebral tissue oxygen saturation (scto2) are measured before (pre-sitting in supine position) and after patients assumed bcp.

Eligibility criteria:
inclusion criteria: elective arthroscopic shoulder surgery under general anesthesia in beach chair position exclusion criteria: preexisting cerebrovascular diseases, history of orthostatic hypotension, age less than 18 yr, and the american society of anesthesiologists physical status iv or v

Keywords: cerebral oxygen saturation beach chair position hemodynamic jugular venous oximetry
cardiac health, mood, & neuroimmune activation

Conditions: Heart Failure; Depression

Summary: the study is designed to find out more about how mood and the nervous system affect the body's immune system. the investigators plan to study this in people who have been identified by their physician as being at-risk for the development of heart failure. there will be approximately 525 individuals participating in this study at ucsd and at the vasdhs. individuals who will be asked to take part in this study will have a functional or structural heart problem apparent on an echocardiogram, or a previous heart attack, but no symptoms of heart failure. some individuals will only complete one assessment (consisting of psychological questionnaires and interview, walk test, blood draw, and body measurements), whereas others deemed "high-risk" on the basis of a laboratory test, will be asked to complete that same assessment every 6 months for the duration of the study.


Eligibility criteria:
inclusion criteria: 1. age range 18 years or older 2. acc/aha classification stage b hf patients 3. receiving optimal treatment according to their cardiologist and/or internists 4. an echocardiogram within the past 12 months 5. ejection fraction: as described below in initial screening and identification of stage b patients 6. men and women of all ethnicities and races 7. ability and physician clearance to perform mild exercise 8. with and without depressive symptoms and dsm-iv mdd 9. ability to fully understand all elements of and sign the written informed consent before initiation of the study exclusion criteria: 1. history of recent myocardial infarction (3 months) 2. significant aortic or mitral stenosis, angina not adequately managed with nitrates 3. coronary revascularization, mitral valve repair or any other cardiac surgery or implantation of a biventricular pacemaker within the past 2 months 4. hypertension \>180/110 mm hg 5. recent stroke or significant cerebral neurological impairment 6. severe copd, patients who require mechanical ventilation, with cardiogenic shock, volume depletion 7. subjects with high suicide risk 8. immune-related disorders including infectious diseases and autoimmune and inflammatory disorders 9. morbid obesity: bmi \> 40 due to likelihood of inability to perform exercise 10. women who are pregnant or nursing 11. major mental illness as determined by referring provider
frequency of hymenoptera-stings in patients under allergen-specific immunotherapy (sit)

Conditions: Hymenoptera Sting Allergy

Summary: in switzerland, 3.5% of the population are suffering from hymenoptera venom allergy. the only causal treatment of hymenoptera alelrty is venom specific immunotherapy. there are however several reasons, which question the relatively broad application of this expensive treatment. that's why we aim at investigating the actual risk for hymenoptera stings in patients undergoing allergen specific immunotherapy against hymenoptera sting allergy


Eligibility criteria:
inclusion criteria: * bee and/or wasp allergic patients treated by sit exclusion criteria: * none
randomized trial sorafenib-pravastatin versus sorafenib alone for the palliative treatment of child-pugh a hepatocellular carcinoma

Conditions: Child-Pugh A Hepatocellular Carcinoma

Summary: principal objective: to evaluate the effect of the combination pravastatin - sorafenib versus sorafenib alone on overall survival in patients with hepatocellular carcinoma developing on child-pugh a cirrhosis who are unsuitable for curative treatment. secondary objectives: evaluate the effect of this treatment on progression-free survival, the time to progression, the time to treatment failure and quality of life (qlq-c30 et fact hep)


Eligibility criteria:
inclusion criteria: * hepatocellular carcinoma diagnosed by: * either a histological examination * or if histological evidence cannot be obtained (ascites, coagulation disorders) the diagnosis can be made in cases of cirrhosis according to easl/aasld 2005 criteria, by revealing a hepatic focal lesion of more than 10 mm * on two dynamic imaging techniques (helical ct-scan, mri, contrast-enhanced ultrasound) for tumours measuring less than 2 cm. the lesion must be characterised by hyperdensity during the arterial phase and wash-out during the delayed portal phase patients who are not suitable for treatment with a curative intent (transplantation, resection, percutaneous destruction) or by chemo-embolisation or with progressive hepatocellular carcinoma after the failure of specific treatment prognostic clip score 0 to 4 child-pugh class a transaminases ≤ 5 n and creatininemia ≤ 1.5 n who: 0, 1 or 2 age more than 18 years foreseeable survival \> 12 weeks possibility of regular follow-up written informed consent exclusion criteria: * extra-hepatic disease that could be life-threatening in the short or medium term another progressive cancer with the exception of in situ cervical cancer, a superficial bladder tumour and treated basocellular carcinoma. any other cancer treated with a curative intent in the previous 3 years can be included in the study heart failure (≥new york heart association class 2), uncontrolled aht or arrhythmia, myocardial infarction in the previous 6 months digestive haemorrhage in the previous month patients who are receiving or have already received treatment with statins or sorafenib pregnancy and breast-feeding. women of child-bearing age must use an effective method of contraception throughout the trial and for 3 months after the end of the treatment.