Kornimate/medical-research-clean huggingface dataset:
suicidal ideation and behavior in korean adolescents with depression

Conditions: Depression

Summary: the purpose of this study is to examine clinical characteristics of korean adolescents with depression who have suicidal ideation and behavior. we formulate those hypotheses. 1. being bullied in peer relationships, excessive use of internet, excessive extra-curricular tutoring, sexual abuse in childhood, physical abuse and emotional neglect are risk factors of suicide in adolescents. 2. depression of parents and negative child-rearing attitude are risk factors of suicidal ideation and behavior in adolescents. 3. emotional quotient (eq) and resilience of adolescent are protective factors of suicide.

korea has reported the highest suicide rate among oecd members and according to the data from the korea national statistical office, suicide is the second major cause of death in adolescents and is increasing. depression, one of the well-known risk factors of suicide in adolescents, can cause maladjustments to school and family life, problems of interpersonal relationship and drug abuse so that work to trigger the suicidal ideation and behavior. in his study, we planned to examine the relationship between suicidal ideation and behavior and several risk factors by using the standardized diagnostic clinical interview, especially an objective suicide evaluating method which has recently developed.

Eligibility criteria:
inclusion criteria: * a subject who has depression (major depressive disorder, dysthymic disorder, depressive disorder nos) diagnosed by kiddie-schedule for affective disorder and schizophrenia (k-sads-pl-k) * subjects and their family (a parent or a grandparent) or their legal representative consent to participate in this study voluntarily * subjects and their family (a parent or a grandparent) or their legal representative are able to understand the meaning of participation in this study and able to reject or ask to leave from this study exclusion criteria: * a patient who has diagnosed with bipolar disorder, psychotic disorder, pervasive developmental disorder, organic brain disease, or epilepsy * a patient with mental retardation who is iq under 70 * a patient who has a severe medical illness (chronic physical disease, cardiovascular, hepatobiliary, nephrology, or respiratory disease and so on)

Keywords: suicide depression adolescents
a pharmacokinetic study of mk-0941 after multiple daily doses in subjects with type 2 diabetes (mk-0941-012)(completed)

Conditions: Diabetes Mellitus, Type 2

Summary: a study to test the pharmacokinetics after twice daily administration of mk-0941 or placebo in subjects with type 2 diabetes who have inadequate control on metformin.


Eligibility criteria:
inclusion criteria: * subject has a bmi \< 42 kg/m2 * subject is taking \>1500 mg metformin per day for at least 8 weeks * subject has hba1c value of 7.0% and \< 11% at screening * subject is willing to follow aha weight maintaining diet and exercise program * subject is a nonsmoker for at least 6 months exclusion criteria: * subject has type 1 diabetes * subject has a history of stroke or chronic seizure * subject has a history of neoplastic disease * subject has a history of gastrointestinal, cardiovascular, blood, liver kidney, respiratory, immunological or genitourinary disorders or diseases * subject is currently taking 2 or more diabetes medications * subject has glaucoma or is blind * if female, subject is pregnant or breastfeeding * subject consumes \> 3 alcoholic beverages per day * subject has had major surgery or has donated blood in the last 4 weeks
the maintenance therapy of capecitabine of advanced gastric cancer

Conditions: Advanced Gastric Cancer

Summary: to confirm the efficacy and safety of xelox with capecitabine maintenance in treatment of advanced gastric cancer (agc)


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * male or female * patients with stage iv gastric cancer by pathology or cytology and imaging diagnosis , or after previous surgery or radiotherapy or chemotherapy in patients with stage iv gastric cancer progression , there recist criteria evaluable lesions ; * ecog performance status score 0-2 ; * expected survival time more than three months ; * adequate hematologic parameters and liver and kidney function ; * bone marrow : absolute neutrophil count (anc) ≥ 1.5 × 109 / l, platelets ≥ 75 × 109 / l, hemoglobin ≥ 80g / l; * liver: bilirubin ≤ 1.5 times the upper limit of normal , alt ast values ≤ 2.5 times the upper limit of normal ; * renal : serum creatinine ≤ uln ; * informed consent of patients or their agents , and signed informed consent. exclusion criteria: * for patients allergic to capecitabine ; * patients with cns metastases * undermine the integrity of the upper gastrointestinal tract , malabsorption syndrome , or unable to take oral medication ; * patients with coronary heart disease , angina , myocardial infarction , arrhythmia, cerebral thrombosis, stroke and other serious cardiovascular and cerebrovascular disease ; * or in combination with other anti-tumor therapy in patients participating in clinical trials of other interventions ; * pregnancy or breast-feeding patients , or fertility without taking adequate contraceptive measures were ; * the researchers believe that this test is not suitable for those who participate .
bowel dysfunction 3 years after anterior resection a in a swedish national cohort

Conditions: Low Anterior Resection Syndrome; Rectal Cancer

Summary: the primary objectives are to evaluate the prevalence of lars and quality of life in rectal cancer patients 3 years after anterior resection, to investigate if anastomotic technique is a risk factor for major lars and to study the prevalence of colostomy 3 years after anterior resection and evaluate stoma function according to the stoma scale in eortc qlq-cr29.

all patients who have undergone anterior resection for rectal cancer between q1 2015 and q4 2017 have been identified in the swedish colorectal cancer registry (scrcr). three years after surgery the patients were sent a questionnaire including the lars (low anterior resection syndrome)-score, the quality of life questionnaire eortc qlq 30 and cr29 in addition to a questionnaire regarding prevalence of remaining stoma.the patient cohort will be divided into two groups operated with total (tme) or partial (pme) mesorectal excision for further analyses. patients with a stoma will be analysed separately. prevalence of major lars and quality of life, qol, 3 years after anterior resection will be assessed by the eortc qlq-c30 and by calculation of lars score with categories "no" (0-20 points), "minor" (21-29) and "major" (30-42). the lars score will be dichotomized into the categories no/minor and major lars. stoma function will be evaluated by the stoma scale in eortc qlq-cr29.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of rectal cancer in sweden * operated on with anterior resection between q1 2015 and q4 2017 in sweden, with or without defunctioning stoma exclusion criteria: * age \<18 years * dementia, * unable to understand swedish language
validation of the dutch translation of the tobacco, alcohol, prescription medication and other substances (taps)-tool

Conditions: Substance Use; Severe Mental Disorder; Intellectual Disability, Mild

Summary: the aim of the study is to investigate the reliability and validity of the dutch version of the taps-tool. this will be investigated in 2 groups: patients without intellectual disabilities treated in flexible assertive community treatment (fact) teams and patients with intellectual disabilities. for the later group, an adjusted version of the taps-tool will be developed. for both groups the taps outcome will be compared to a golden standard.

all fact teams in the participating organization (ggz oost brabant) work through a standardized care pattern which implicates screening and assessment on several areas. at the start of the treatment all patients are assessed for intellectual disabilities, trauma related symptoms, addiction, quality of life, level of psychiatric complaints, social functioning, and phase of recovery. subsequently quality of life and the level of psychiatric complaints is measured yearly. for this research question a small golden standard instrument was added to the standard screening and assessment. for people with intellectual disabilities (id) who get an extensive assessment of substance use problems in their (standard) treatment, permission to participate on the taps (version for id) was asked.

Eligibility criteria:
inclusion criteria: * all patients treated in the participating fact teams and for patients treated at the lvb-p (department for patients with intellectual disabilities and psychiatric disorders \[dutch name\]) department of the ggz oost brabant or the oro foundation (oro is no abbreviation but just a name of the institute). exclusion criteria: * if patients do not have sufficient command of the dutch language or cannot concentrate for 20 minutes, the instruments are not taken

Keywords: taps screener
upper-extremity bone or joint surgery: long term outcome

Conditions: Upper Extremity Fractures; Upper Extremity Non-Fracture Bone and Joint Conditions

Summary: the specific aim of the study is to obtain long-term follow-up information on patients who have completed their standard clinical care in the orthopaedic hand and upper extremity service. the study will help to qualify and quantify long-term recovery and outcomes from uncommon upper extremity fractures, as well as non-fracture bone and joint conditions. the hypotheses vary, but generally focus on the patterns of injury, the results of treatment and the complications encountered.


Eligibility criteria:
inclusion criteria: * subjects with a history of complex arm or leg trauma who have completed their normal care in the orthopaedic hand and upper extremity service exclusion criteria: * vulnerable populations
rtms in managing individuals with chronic low back pain and comorbid insomnia

Conditions: Chronic Pain; Insomnia

Summary: this pilot randomized controlled trial (rct) aims to investigate the feasibility and efficiency of delivering different rtms protocols in individuals with clbp and insomnia. participants will be randomly assigned to either the primary motor cortex (m1) rtms, the dorsolateral prefrontal cortex (dlpfc) rtms, or sham stimulation.

sleep disturbance exacerbates pain perception, disability, and poor prognosis in individuals with chronic low back pain (clbp). a recent systematic review demonstrated that improvements in sleep disturbance were associated with corresponding improvements in pain intensity, recovery, and disability in individuals with clbp. these findings indicate that achieving restorative sleep is likely to mitigate chronic pain symptoms. the application of rtms at a specific frequency over a focal brain area has been proposed as a promising treatment for chronic pain and insomnia independently. to date, no studies have compared the effectiveness of different rtms protocols in treating comorbid clbp and insomnia. given the above, the current study aims to investigate the feasibility and acceptability of delivering different rtms protocols in individuals with clbp and insomnia and explore the relative therapeutic efficacy of these protocols on pain and sleep parameters at immediate post-treatment and one-month follow-up.

Eligibility criteria:
inclusion criteria: 1. participants aged between18 and 65 years; 2. willing to participate in the study and randomization; 3. having stable pharmacological or nonpharmacological treatments for pain or sleep at least one month prior to study participation; 4. having clbp (defined as pain between 12 ribs and gluteal crease with or without leg pain that has persisted for at least three months) 5. diagnosing insomnia using the brief insomnia questionnaire (biq) based on the criteria outlined in the diagnostic and statistical manual of mental disorders 5th edition (dsm-5) exclusion criteria 1. specific causes of clbp (e.g., spondylosis, spondyloarthropathy, or vertebral fracture); 2. pregnancy or nursing; 3. previous spinal surgery; 4. inflammatory or autoimmune diseases; 5. other sleep disorders (e.g., sleep apnea or restless leg); 6. presence of severe psychopathologies, neurological, or physical disease directly related to the onset of insomnia (e.g., depression, substance abuse, or alcohol abuse); 7. severe dependence on hypnotic drugs; 8. concurrent receipt of new treatments outside the scope of the study; 9. contraindications to use rtms (e.g., severe head trauma, intracranial hypertension, implanted ferromagnetic devices, history of epilepsy).

Keywords: chronic low back pain insomnia rtms rct
open trial of family-based treatment for anorexia nervosa

Conditions: Anorexia Nervosa

Summary: this trial seeks to investigate the feasibility and effectiveness of delivering a newly manualized family-based treatment for adolescents with anorexia nervosa

this open trial seeks to investigate the feasibility and effectiveness of delivering a newly manualized family-based treatment for adolescents with anorexia nervosa at a site beyond the treatment's origin. adolescents ages 12-17 with anorexia nervosa or subthreshold anorexia nervosa were treated with up to one year of this approach.

Eligibility criteria:
inclusion criteria: * age 12-17 * diagnosis of full or subthreshold anorexia nervosa * at least one parent or guardian willing to participate in treatment exclusion criteria: * bipolar disorder, psychotic disorder, substance dependence * mental retardation * acute suicidal risk * acute or unstable, poorly controlled chronic medical illness * weight below 75% ideal body weight

Keywords: adolescents anorexia eating disorder family therapy
evaluation of the stop-bang screening questionnaire in a sleep clinic

Conditions: Obstructive Sleep Apnea

Summary: although obstructive sleep apnea (osa) is common, most of the patients are undiagnosed. osa is associated with a large number of co-morbidities, and thus, it is of great importance to identify the patients and start treatment in order to reduce the risks for complications. current screening tools are quite unspecific and the golden standard methodology for diagnosis, polysomnography, is expensive and time consuming, thus not suitable for screening. in perioperative medicine the stop bang screening questionnaire is currently the recomended screening tool, however this questionnaire has only been evaluated in a sleep clinic in a very limited numbers of patients.


Eligibility criteria:
inclusion criteria: * more than 18 years old * first or part of the first visit to a sleep clinic * planned or just conducted polysomography exclusion criteria: * not able to understand the information and sign informed consent
carotid atherosclerotic disease following childhood scalp irradiation

Conditions: Atherosclerosis

Summary: background: during the first half of the 20th century, scalp irradiation was a standard treatment for induction of epilation in children suffering from tinea capitis. these children are now more than 50 years old and the aim was to investigate the possible association between their childhood low dose irradiation exposure and development of carotid atherosclerotic disease in adulthood. methods: the study included 145 individuals treated by irradiation in their childhood, and 150 matched control subjects with no history of irradiation. b-mode ultrasound imaging and us doppler were used to measure carotid and femoral stenosis and intima-media thickness (imt). blood samples were taken for lipid profile and homocysteine evaluation.


Eligibility criteria:
inclusion criteria: * age 18 or older * childhood scalp irradiation or mach controls * writen informed consent exclusion criteria: * inability to give written informed consent
analysis of influencing factors and construction of prediction models of artificial joint replacement in china

Conditions: Knee Arthropathy; Hip Arthropathy; Shoulder Arthropathy; Ankle Arthropathy; Elbow Arthropathy

Summary: the project intends to analyze the epidemiological characteristics, risk factors, complications and resource utilization of artificial joint replacement in china through the inpatient data collected by the hospital quality monitoring system (hqms). the hqms database is a mandatory electronic inpatient database system developed by the national health commission of the people's republic of china. since 2013, tertiary hospitals have been required to upload their inpatient discharge records. by 2019, the hqms database has included more than 230 million standardized inpatient discharge records of over 1000 hospitals across all 31 provincial-level administrative regions in mainland china. patient demographics, clinical diagnosis, procedures and operations, drug use, costs and complications were all recorded in the hqms database. the investigators planned to include five types of arthroplasty, including knee arthroplasty, hip arthroplasty, shoulder arthroplasty, ankle arthroplasty and elbow arthroplasty. the data analysis will be conformed to the principle of confidentiality and will not reveal the privacy of those patients. the data will be only used for this research project and there is no conflict of interest. it is in line with the principles of ethics, harmlessness and fairness. this study was authorized by the hqms committee board and approved by the institutional review board, with waiver of informed consent.


Eligibility criteria:
inclusion criteria: * patients who underwent knee, hip, shoulder, ankle and elbow arthroplasty in hqms exclusion criteria: * patients who didn't undergo knee, hip, shoulder, ankle and elbow arthroplasty * patients with missing demographics or medical data
evaluation of a dual action pneumatic compression device: patient ease of use and comfort

Conditions: Chronic Venous Insufficiency

Summary: the purpose of this study is to determine the ease of use and comfort of the actitouch dual action pneumatic compression device in patients with unilateral or bilateral chronic venous insufficiency (cvi) with or without venous leg ulcers, as compared to standard compression.

subjects will be randomized to receive either the actitouch system or standard compression garments, and will respond to symptom surveys and quality of life surveys to assess comfort and ease of use of each. these will be conducted at baseline, at day 15 and day 30.

Eligibility criteria:
inclusion criteria: * diagnosis of unilateral or bilateral cvi with or without leg ulcers * documented history of low adherence to compression garment therapy * ceap classification c3-c6 * leg circumferences within the following ranges: ankle 12-44cm, calf 22-6m, below the knee 22-68cm exclusion criteria: * history of skin sensitivity to any of the components of actitouch or compression garments * history of acute (deep vein thrombosis) dvt or (pulmonary embolism) pe within the last 3 months * ankle brachial index (abi) \< 0.8 * acute thrombophlebitis * history of pulmonary edema or decompensated congestive heart failure * currently has an active infection of the skin such as cellulitis requiring antibiotics * poorly controlled diabetes with an hba1c value of \>10% * exhibits any condition which, according to the pi, justifies the subjects exclusion from the study, such as a medical condition where an increase in venous or lymphatic return is undesirable. * subjects with open ulcers must be able to follow their care regimen for ulcer healing concurrently with the assigned study regimen. * participating in another clinical trial * changes to medications that affect edema within the last 30 days * currently pregnant or trying to become pregnant

Keywords: chronic venous insufficiency venous leg ulcers pneumatic compression
glucose frequent of a1gdm in labor

Conditions: Gestational Diabetes, Controlled by Diet

Summary: this is a prospective double arm study in patients with gestational diabetes mellitus (gdm) utilizing frequent (single fingerstick on admission) vs infrequent glucose monitoring in labor (q 4 hours in latent labor and every 2 hours in active labor). primary objective: the primary outcome is glucose value of the neonate at birth. secondary objectives: determine rates of insulin requirements within different monitoring techniques. determine if there is a difference in neonatal intensive care unit (nicu) admission within different monitoring techniques. determine neonatal blood glucose concentrations at 24 hours of life, number of glucose treatments, and neonatal hyperbilirubinemia. secondary characteristics to be viewed for each diagnosis; bmi, race, age, and parity.


Eligibility criteria:
inclusion criteria: * all female patients of reproductive age (menarche-menopause: 18-51 years) who have the diagnosis diet controlled gdm * patient with singleton gestation presenting in labor or for induction * patients who had "good" glucose control and were a1gdm. good control; * - patient with overall outpatient glucose average of less than 100 * - no evidence of fetopathy, large for gestational age or polyhydramnios. * - hgb a1c \<5.7 exclusion criteria: • if patient's admission accu check is \>120
unravel mgus (monoclonal gammopathy of unknown significance)

Conditions: Monoclonal Gammopathy of Unknown Significance

Summary: this is a study to investigate the functional consequences of paraprotein production in mgus (monoclonal gammopathy of unknown significance).

monoclonal gammopathy of unknown significance (mgus) is a common haematological condition. it is characterised by proliferation of a b lymphocyte clone and it's associated antibody (paraprotein). in most cases there are no clinical symptoms, however, in a small number of individuals there may be an interaction of the paraprotein with a molecule expressed by the body (self antigen). this can have effects on the normal function of this molecule and/or cause disease. the study aims to investigate the functional consequences of paraprotein production in mgus.

Eligibility criteria:
inclusion criteria: participants must comply with the following criteria in order to be eligible for the study: * be aged ≥18 years at the time the informed consent form is signed * have a confirmed and documented monoclonal gammopathy of unknown significance (mgus) diagnosis * read and understood the participant information sheet, and signed an institutional review board/independent ethics committee (irb/iec) approved informed consent form prior to any study- specific evaluation exclusion criteria: participants will be excluded from joining the study if they match any of the criteria below: * pre-existing diagnosis of myeloma/lymphoma * participation in a therapeutic clinical study within 28 days or (5 half lives, whichever is longer) of enrolment or during this study * any other reason the clinical investigator (ci) considers the participant should not join the study

Keywords: mgus