Kornimate/medical-research-clean huggingface dataset:
physiotherapy/hypnosis for avc patients

Conditions: Stroke

Summary: impact of physical therapy with hypnosis on the functional capacity of the upper limb in stroked patients.

the cerebrovascular accident (cva) is a pathology generating many disabled people. physiotherapy is one of the usual rehabilitation techniques for a patient with sequelae of ischemia or cerebral hemorrhage. combined with another therapeutic approach, hypnosis, it could increase the patient's motor performance.

Eligibility criteria:
inclusion criteria: * adults aged 18 to 80 years old * having experienced a stroke more than 3 months ago * understanding and proficient in the french language * having a functional capacity deficit in at least one of the two upper limbs * being able to independently travel to the yerne medical center for necessary study appointments. exclusion criteria: * being under 18 or over 80 years old * having a history of upper limb injuries (fractures, prosthetics, etc.) * having wernicke's aphasia (language comprehension disorder) * having frontal lobe syndrome * undergoing chemotherapy * having respiratory disorders (respiratory failure of more than 70%) or receiving oxygen therapy * having epilepsy * having dementia * having untreated hearing impairments * being diagnosed with schizophrenia or paranoïa * experiencing significant concentration difficulties

Keywords: hypnosis, stroke, physiotherapy
an evaluation the effect of superhydration versus dextrose 10% for prevention of post operative nausea and vomiting after laparoscopic cholecystectomy (prospective randomised controlled study)

Conditions: Postoperative Nausea and Vomiting (PONV)

Summary: the goal of this clinical trial is to learn if dextrose 10% or superhydration works to prevent postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. . the main questions it aims to answer are: does dextrose 10% or superhydration lower the number of times participants gets an episode of nausea and vomititng after laparoscopic cholecystectomy surgery? researchers will compare dextrose 10% versus superhydration to a placebo (a look-alike substance that contains no drug) to see if glucose 10% or superhydation can work to prevent postoperative nausea and vomiting. participants will: take dextrose 10% or superhydration or a placebo in the operation monitored for 4 hours after surgery to check on their nausea and vomiting state


Eligibility criteria:
inclusion criteria: 1. age: 21- 60 years 2. patients with asa classification i and ii exclusion criteria: 1. declining to give written informed consent. 2. patients with morbid obesity (bmi \> 40). 3. asa classification iii-v. 4. sever hypertension and heart failure. 5. significant hepatic or renal disorder. 6. patients with diagnosed diabetes mellitus type 1 or type 2. 7. patients with history of ponv currently receiving steroids or antiemetics. 8. pregnant or menstruating patients.

Keywords: postoperative nausea and vomiting nausea vomiting laparoscopic cholecystectomy superhydration glucose 10% dextrose 10%
abdominal wall closure with triclosan-coated suture

Conditions: Infection

Summary: after open colorectal surgery the surgical site infection (ssi) is very high among abdominal surgeries. the goal of the investigators randomized, prospective, multicentric, internet-based study is to compare rate of ssi after surgery of colon and rectum by using triclosan-coated suture for abdominal wall closure. 180-180 cases in seven centres are involved in this study. two arms are separated by computer randomization at abdominal wall closure: application of triclosan-coated and non-coated pds suture (pds versus pds-plus). triclosan is an antiseptic material which the investigators hope will provide better local infection control at the site with reducing the risk of bacterial colonisation.

after open colorectal surgery the surgical site infection (ssi) is very high among abdominal surgeries. the goal of our randomized, prospective, multicentric, internet-based study is to compare rate of ssi after surgery of colon and rectum by using triclosan-coated suture for abdominal wall closure. two arms are separated by computer randomization at abdominal wall closure: application of triclosan-coated and non-coated pds suture (pds versus pds-plus). triclosan is an antiseptic material which we hope provides better local infection control at the site with reducing the risk of bacterial colonisation. attached website: www.itplan.hu/sebstudy/ randomizing patients: 1. logging in (completing the id panel) 2. on-line randomization 3. patient appears on list 4. operation (recording details) 5. recording - post-operation events * complications * control examination

Eligibility criteria:
inclusion criteria: * elective (subjected to bowel preparation) operations * benign or malignant colon or rectal disease * age: 18-80 * bowel opening is made during operation exclusion criteria: 1. cannot be randomized: * systemic diseases influencing local surgical site healing * insulin-dependent diabetes mellitus * child b-c liver cirrhosis * kidney disease requiring dialysis * immune-suppression treatment * ibd * acute surgery or unprepared bowel * after being informed patient does not sign the statement of consent 2. to be excluded later: * surgically incurable tumour * septic state or complication occurred in the post-operational stage * patient withdraws the signed consent before the examination is closed 3. undesirable complication: * sterile surgical site separation * suture break during the post-operational stage

Keywords: surgical site infection elective colorectal surgery level of surgical site infection complication of surgical site infection type of changed bandage frequency of bandage changing
effect of body tilting on diaphragm excursion and thickness in the stroke patients with tracheotomy by ultrasonography

Conditions: Stroke; Diaphragm Injury; Tracheostomy

Summary: the purpose of this study was to examine whether if the effect of standing with assistance of the tilt table on diaphragm excursion and thickness in the stroke patients with tracheotomy.

40-45 stroke patients with tracheotomy were passive tilting (α=0°, 30°, 60°) by an electric tilt table in the random order. the diaphragm excursion and thickness were measured by ultrasonography on three tilting during the quiet breathing. besides, the intraclass correlation coefficient (icc) were calculated to assess the reliability of the diaphragm ultrasonography in this population.

Eligibility criteria:
inclusion criteria: 1. currently diagnosed with ischemic or hemorrhagic stroke by ct or mri; 2. right unilateral or bilateral limb with hemiparesis; 3. age over 18 years; 4. bmi\<35 kg/m2; 5. within 2 weeks to 12 months； 6. the tracheotomy tube replacement; 7. non first time standing assisted with tilt table. exclusion criteria: 1. undergoing mechanical ventilation; 2. postural hypotension; 3. myocardial infarction in the first 3 months; 4. deep vein thrombosis; 5. angina or acute heart failure; 6. complicated with other primary pulmonary diseases, such as tuberculosis,；pneumothorax, and chronic obstructive pulmonary disease and so on; 7. a past episode of abdominal or chest surgery.

Keywords: the stroke patients with tracheotomy diaphragm excursion diaphragm thickness ultrasonography
a study of bonviva/boniva (ibandronate) in biphosphonate-naïve women with post-menopausal osteoporosis

Conditions: Post Menopausal Osteoporosis

Summary: this single arm, open label study will assess the efficacy and safety of and compliance to treatment with bonviva/boniva (ibandronate) in biphosphonate-naïve patients with post-menopausal osteoporosis. patients will receive bonviva/boniva at a dose of 3 mg intravenously every three months. anticipated time on study treatment is 12 months with a follow-up of 12 months.


Eligibility criteria:
inclusion criteria: * female patients, \> 50 years of age * diagnosed osteoporosis * bone mineral density \< minus 2.5 sd or osteoporotic fracture * at least 3 years after menopause exclusion criteria: * impaired renal function * contra-indication to calcium or vitamin d therapy * previous or current treatment with biphosphonates
online culture for mental health in people aged 16-24

Conditions: Depression; Anxiety

Summary: o-ace pop is a randomised controlled trial of an online cultural experience named ways of being, compared to a typical museum website (the ashmolean museum). the primary aim is to compare these two interventions by efficacy on mood, distress (depression and anxiety), flourishing and investigate potential mechanisms of action, as well as the feasibility of a larger scale rct.

people of target age will be actively recruited with a link to participant information and e-consent procedures for those who fulfil inclusion criteria and consent to entering their email address. consenting participants will enter a demographic questionnaire. participants will then be emailed a unique id number and requested to complete a baseline assessment on a computer, including self-report measures and online tasks. participants will then be randomised to wob or the ashmolean website. once randomised participants will be requested to log on to the intervention at least once a day for the next three days randomisation and blinding randomisation procedures will be followed. the participants will be aware of which intervention they have been allocated to. all measures are online and self-report. ways of being (wob) is an online cultural experience designed to reduce distress (symptoms of anxiety and depression) and promote positive mental health in people aged 16-24. it is a web-experience based on qualitative research and co-production with people aged 16-24. the experience is based on human centred narratives related to the objects and artworks of the ashmolean museum in oxford and partner museums. in addition, other people's viewpoints on the objects and artworks or narrative, are a focus of the experience. the experience combines text, audio and aesthetic elements. the ashmolean website is a generic museum website owned by the ashmolean museum of art and archaeology at the university of oxford. the ashmolean is the oldest public museum in the uk, and has incredibly rich and diverse collections from around the globe, ranging from classical civilisation to the pre-raphaelites and modern art. the website is aimed at general museum visitors, tourists, families, primary, secondary and tertiary learners, teachers, and those with specialist cultural interests. statistical analysis plan the main outcome will be the mean panas score at each time point. these will be regressed on time (pre-intervention vs. during, exit and follow up), a group indicator (wob vs. the ashmolean website), and their interaction.

Eligibility criteria:
inclusion criteria: people ages 16-24 exclusion criteria: * no access to a laptop or desktop computer
diagnostic value of patient - reported and clinically verified olfactory disorders (covid-19)

Conditions: COVID-19

Summary: participants are healthcare workers and adult outpatients referred in a covid-19 screening center. patients-reported symptoms are collected, then participants underwent a simple olfactory test (coda for clinical olfactory dysfunction assessment), prior to swabbing for sars-cov-2 diagnosis (rt-pcr). we aimed to evaluate the prevalence of smell and taste disorders, and to calculate the diagnostic value of patient-reported and clinically verified smell disorders in persons with suspected covid-19.


Eligibility criteria:
inclusion criteria: * symptoms compatible with covid-19 * close exposure to a confirmed covid-19 index case * ambulatory (asymptomatic, or if symptomatic, did not require hospitalisation, thus with initial mild disease) exclusion criteria: * known history of smell and taste disorders * testing inability (cognitive impairment, non native french speakers, test malingering) * testing contraindication (children, pregnancy, breastfeeding, specific allergies).

Keywords: sars-cov-2 covid-19 diagnostic value sensitivity specificity prevalence positive predictive value negative predictive value epidemiology diagnostic test anosmia ageusia olfactory disorders gustatory disorders smell disorders taste disorders
effect of thrive during apneic oxygenation in general anesthesia on biomarkers

Conditions: Anesthesia; Oxygen Toxicity

Summary: oxygenation with high-flow nasal cannula with 100% oxygen have now been evaluated in a number of studies and the data are convincing. the thrive technique is able to oxygenate patients safely and vital parameters has been shown to be stable. but it is of great importance to evaluate this new concept regarding other potential negative physiological aspects such as biological stress response detected by blood-bourne biomarkers before implementing it into clinical practice.


Eligibility criteria:
inclusion criteria: 1. adults, \>18 years old. 2. laryngeal-surgery where apnea is of benefit for the surgeon (eg. intraoral or laryngeal surgery). 3. capable of understanding the study information and sign the written consent. exclusion criteria: 1. american society of anaesthesiologist severity score \>2 2. new york heart association score \>2 3. pacemaker or icd. 4. body mass index \>35 5. pregnancy 6. manifest cardiac failure or coronary disease 7. severe gastrointestinal reflux. 8. neuromuscular disorder

Keywords: thrive
sleep apnoea management by a communication based technology (ict)

Conditions: Obstructive Sleep Apnea; Telemedicine

Summary: this project develops a new form of management of subjects with suspected sahs and different sleep disorders by applying information and communications technologies (ict).

sleep apnea hypopnea syndrome (sahs) is a prevalent disease with significant morbidity resulting in long waiting lists and high health care costs. therefore, alternative cost-effective approaches are urgently needed. a possible procedure is telemedicine based on ict. the design of the study is prospective, randomized, controlled, open and parallel. a ict-based out of hospital management of sahs is implemented to be compared with the classical in-hospital management. the main objectives were the evaluation of both groups and the analysis of efficacy and cost effectiveness of two sahs management programs. this is a 3 month randomized, with parallel groups study. participants will be patients with suspicion of sahs derived to the investigators' sleep unit. patients are randomized in two groups; 1) classical in-hospital group: polysomnography or home respiratory polygraphy (hrp), cpap titration and treatment and hospital follow-up; and 2) ict group: 3 consecutive hrps, automatic cpap treatment and control by phone/video conferences and data transmission by using a custom designed platform.

Eligibility criteria:
inclusion criteria: * clinical suspicion of sahs * use of smartphone and internet exclusion criteria: * severe hypersomnia * central apneas or other sleep disorder * previous cpap treatment * unstable diseases * profession of risk * not able to complete questionnaires * no written informed consent

Keywords: sleep apnea communication based technology ict
the surem traf3ip2 level and atherosclerotic plaque development in human

Conditions: Coronary Heart Disease, Susceptibility to, 1

Summary: to evaluate the association of surem traf3ip2 levels with the atherosclerotic plaque development in human

previous study had concluded that traf3ip2 plays a causal role in atherosclerotic plaque development and vulnerability in mice. however, no human data was available. in the present study, patients who receive coronary angiography will be enrolled. their surem traf3ip2 levels will be tested using elasa. the association of surem traf3ip2 levels with the atherosclerotic plaque will be evaluated.

Eligibility criteria:
inclusion criteria: 1. patients with suspected coronary heart disease 2. patients received coronary angiography exclusion criteria: 1. nyha iii-iv 2. malignant tumor 3. acute infection 4. thyroid dysfunction

Keywords: traf3ip2, coronary angiography, coronary deart disease
use of a squatting assist device in patients with constipation

Conditions: Constipation

Summary: constipation is a very common problem. western style toilets that are nearly universal in the united states require the person to sit on the toilet. however, results from uncontrolled studies suggests that a squatting posture (as prevalent in many foreign countries) may be better at facilitating evacuation compared to a western style commode. one uncontrolled, unpublished study suggests that a footstool improved bowel symptoms in nearly 98% of 153 constipated participants. hence, the investigators propose to evaluate the benefits of a footstool on symptoms and anorectal functions in constipated patients. hypothesis: the regular squatting assist device (7 inches) but not a sham device (2 inches tall) will improve symptoms of constipation.


Eligibility criteria:
inclusion criteria: * able to communicate adequately with the investigator and to comply with the requirements for the entire study * meet rome iii criteria for functional constipation as assessed by questionnaires in period 1, i.e., report at least 2 of the following symptoms for last 3 months or more with symptom onset at least 6 months prior to diagnosis: a) \<3 sbms/week b) hard or lumpy stools ≥ 25% of time c) straining ≥ 25% of time d) sense of incomplete evacuation ≥ 25% of time e) feeling of anorectal blockage ≥ 25% of time or f) manual maneuvers to facilitate defecation ≥ 25% of time. patients who meet rome iii criteria for irritable bowel syndrome will also be eligible provided they also meet above criteria. exclusion criteria: * current use of opioid analgesics. patients on opioids will be allowed to participate if they have discontinued them for at least 3 days (72 hrs.) before date of screening and are willing to stay off them for the duration of the study. * current use of anticholinergics (e.g. nortriptyline, amitriptyline, hyoscyamine). patients who use low dose tricyclic antidepressants (nortriptyline upto 50 mg/day or amitriptyline upto 25 mg/day ) will be eligible provided they do not increase the dose during the study period. patients on higher doses or on other anticholinergics are eligible to participate if they can discontinue their medication at least 3 days (72 hrs) before the date of screening and are willing to stay off them till the study is complete. * current use of laxatives (miralax, ex-lax, senna, herbal supplements), linaclotide, lubiprostone, and prucalopride to treat constipation- patients using these medications will be eligible to participate if they can discontinue the medication at least 3 days (72 hrs.) before the date of screening and are willing to stay off them till the study is complete.
functional and value-added dairy products and blood glucose control

Conditions: Blood Glucose, High; Metabolic Disease; Overweight and Obesity

Summary: milk proteins possess multiple biological activities including their effect on blood glucose control, satiety and energy intake. the design of functional food products with added milk protein fractions has many challenges related to their inferior sensory properties. chocolate milk presents the universal vehicle for added milk protein fractions that might partially mask their sensory characteristics. however, commercially produced chocolate milk has a significant amount of added sugar. this project will investigate the properties of a value-added dairy product (chocolate milk with reduced sugar content) enriched with individual milk protein fractions on characteristics of blood glucose control, satiety and energy intake in young healthy adults.


Eligibility criteria:
inclusion criteria: * 19-35 y males and females, non-smokers exclusion criteria: * having any diseases, irregular menses in females, smoking (all types), taking medications known to influence blood glucose control, skipping breakfast, and having emotional, or learning problems that would affect their ability to participate in the study as required. individuals with known food allergies and lactose intolerance will be also excluded.

Keywords: sugar intake sweeteners milk proteins diabetes obesity sweetened food products chocolate milk blood glucose insulin satiety food intake casein whey protein
defining inflammatory markers of cardiovascular disease in patients with myelodysplastic syndromes

Conditions: Myelodysplastic Syndromes, Adult

Summary: why is this research study being conducted? * the study wants to find out why people with a type of blood cancer called myelodysplastic syndromes (mds) are more likely to have heart problems like heart disease and stroke. * researchers also want to see if certain proteins related to inflammation in the body can help predict these heart issues in mds patients. * by understanding this better, researchers hope to find new ways to detect and manage heart disease risks in people with mds

what is involved in the study? * this study will follow patients with mds over 6 months. * participants will come to the hospital for the first visit. participants will learn about the study, sign papers to join the study, and share some basic health information. participants will also give a blood sample of 10 milliliters after not eating overnight. * after the first visit, participants will come back to the hospital once a week for 3 weeks to give more blood samples after fasting overnight. * the study team will call participants the day before each scheduled blood draw to remind you of your appointment. * then participants will return to the hospital for another visits once a month for the next 5 months. participants will talk about any changes in their health and give a blood sample at each visit. * participants won't get any treatment as part of this study, but their participation will help researchers learn how inflammation affects the health of people with mds * researchers will collect a small amount of blood (6-10 ml) per visit * these blood collections are a normal part of medical care and won't require participants to come in more often than usual. the frequency of visits will be part of the routine care for myelodysplastic syndrome at the cancer center. extra blood will be collected during standard of care blood draws in the clinic. * sessions will take about 20 minutes.

Eligibility criteria:
inclusion criteria: * age ≥18 years * histologically confirmed diagnosis of mds by bone marrow biopsy morphology, using the 2022 world health organization (who) classification for myeloid neoplasms * eastern cooperative oncology group (ecog) performance status ≤3 * expected survival of at least 6 months * ability to provide consent exclusion criteria: * cases meeting 2022 who criteria of mds with excess blasts 2 as initial diagnosis * hematopoietic stem cell transplantation expected within 6 months

Keywords: myelodysplastic syndromes hematology