Kornimate/medical-research-clean huggingface dataset:
community pharmacist intervention to enhance adherence in cardiovascular drug initiators

Conditions: Cardiovascular Diseases; Cardiovascular Disease Prevention

Summary: the goal of this clinical trial is to evaluate a community pharmacist intervention aimed at improving medication adherence in patients starting newly prescribed medication for cardiovascular disease prevention. the main questions it aims to answer are: * does this community pharmacist intervention improve medication adherence? * which patients benefit the most from the intervention? * how do patients experience the start-up of newly prescribed medication (which questions do they have and do they experience side effects?)? * how do patients and pharmacists experience the intervention?


Eligibility criteria:
inclusion criteria: * patients presenting with a first prescription for one of the following drug classes: antihypertensive drugs (= low-ceiling diuretics, beta blocking agents (excl. non-selective beta-blocking agents), ace inhibitors, angiotensin ii receptor blockers, calcium channel blockers), lipid-lowering drugs (= statins), antidiabetic drugs (= metformin, glucagon-like peptide-1 (glp-1) analogues, sodium-glucose co-transporter 2 (sglt2) inhibitors), or any combination thereof. * age 18 years or older * community-dwelling exclusion criteria: * the drug is prescribed for a non-cardiovascular indication (e.g. beta-blocking agent for migraine prophylaxis) * communication with the patient is not possible (e.g. due to cognitive impairment, insufficient knowledge of dutch or french language)

Keywords: medication adherence
combination chemotherapy plus peripheral stem cell transplantation in treating patients with refractory chronic lymphocytic leukemia

Conditions: Leukemia

Summary: rationale: drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy and kill more cancer cells. purpose: phase i/ii trial to study the effectiveness of combination chemotherapy plus peripheral stem cell transplantation in treating patients with refractory chronic lymphocytic leukemia.

objectives: i. determine the feasibility and toxicity of using allogeneic peripheral blood stem cell transplantation after intensive, but non-myeloablative chemotherapy with fludarabine/cyclophosphamide in patients with advanced chronic lymphocytic leukemia. ii. determine the engraftment kinetics and degree of chimerism available with this strategy. outline: this is a nonrandomized, dose-seeking study. stem cell donors receive g-csf for 4 days prior to and throughout stem cell harvest. patients receive intensive chemotherapy with fludarabine and cyclophosphamide for 3 days, with patients entered at increasing doses of both drugs until the dose allowing engraftment is determined. three days after intensive chemotherapy, allogeneic stem cells are infused. responding patients who do not experience worse than grade 1 acute graft-vs.-host disease receive additional stem cell infusions after 60 and 120 days. patients are followed monthly for 4 months, at 6 and 12 months, then yearly for 5 years. projected accrual: up to 25 patients will be entered.

Eligibility criteria:
disease characteristics: advanced chronic lymphocytic leukemia (rai stage 3 or 4) with at least one of the following high-risk factors: beta-2 microglobulin 3 or greater abnormalities of chromosome 17 other cytogenetic abnormalities refractory to fludarabine-based chemotherapy or failure to achieve complete remission after 6 courses of a fludarabine-based regimen hla-identical sibling donor willing and able to undergo apheresis for harvest of g-csf-stimulated peripheral blood stem cells patient characteristics: age: 65 and under performance status: zubrod 0 or 1 hematopoietic: not specified hepatic: bilirubin less than 1.5 mg/dl renal: creatinine less than 1.5 mg/dl cardiovascular: no symptomatic cardiac disease pulmonary: no symptomatic pulmonary disease other: no active uncontrolled infection prior concurrent therapy: see disease characteristics

Keywords: stage iii chronic lymphocytic leukemia stage iv chronic lymphocytic leukemia refractory chronic lymphocytic leukemia
laparscopic hernioplasty in recurrent inguinal hernia

Conditions: Recurrent Inguinal Hernia

Summary: the purpose of this study was to compare between laparoscopic transabdominal preperitoneal (tapp) and totally extraperitoneal (tep) repair of inguinal hernia in recurrent inguinal hernia.

the primary objective in this study was to compare postoperative pain between the tapp group and the tep group. the secondary objective was to compare operative time, intraoperative complications (bleeding, bowel injury, vascular injury), postoperative complications (hematoma, seroma, wound infection), length of hospital stay and recurrence rate with possible risk factors which include gender, age, bmi ,cord lipomas and location of the hernia.

Eligibility criteria:
inclusion criteria: * patients diagnosed with unilateral or bilateral recurrent inguinal hernias. * patients between 18 and 70 years old * fit for anesthesia. * agree to participate in the study * both genders were included. exclusion criteria: * unfitness for general anesthesia and operation. * age \ 70 years. * complicated hernias (acute irreducible, obstruction or strangulation). * the presence of mental or psychological disorders. * refusal to participate in the study.

Keywords: tapp tep laparoscopic inguinal hernia recurrent hernia
treatment of graves' hyperthyroidism with selenium plus methimazole

Conditions: Graves' Disease

Summary: evaluation of the efficacy of the combined treatment (methimazole plus selenium) in the control of hyperthyroidism as compared to methimazole alone in 30 graves' disease (gd) untreated patients.

30 untreated gd hyperthyroid patients will be randomized into two groups (a and b). group a patients will be treated with an anti-thyroid drug (methimazole) at the dose aimed to control hyperthyroidism. group b patients will be treated with methimazole plus selenium (160 mg daily). patients will be evaluated at time 0, 45 and 90 days for symptoms of hyperthyroidism (by a specific questionnaire), clinical status (weight, heart rate), laboratory (thyroid function tests, tshr autoantibodies, serum selenium, index of oxidative stress-mda, cholesterol, shbg) and ekg. the aim of the study is to evaluate if the combined treatment (methimazole plus selenium) is more effective than methimazole alone in controlling gd hyperthyroidism.

Eligibility criteria:
inclusion criteria: * hyperthyroid untreated graves' disease patients exclusion criteria: * hyperthyroid treated graves' disease patients

Keywords: hyperthyroidism methimazole selenium
immune status sars-cov-2 in a sample of a tertiary eye health centre

Conditions: History of Covid-19, Seroprevalence

Summary: a sequential combination of different antibodies test against sars-cov-2 is evaluated. the protocol included a rapid test and several elisa tests within a defined cohort of healthcare workers.

in the current pandemic, the assessment of actual covid-19 infections plays an important role in the assessment of the risk and progress of the epidemic. shortly, more and more rapid tests will be available, the aim of which is to be able to obtain a good overview of the immune status of corresponding samples in a timely manner. employees in the health sector are faced with additional challenges, not only due to the tightened hygiene regulations. the concern about infecting other people and/or exposing oneself to a relevant health risk is of great importance. a moderate to high transmission risk can be assumed for ophthalmology. in view of older patients and sometimes unavoidable proximity, targeted and reliable diagnostics can offer the potential to reduce the risk potential for the current situation by determining antibodies. a rapid diagnosis is not yet available outside of clinical studies, especially since deficits in specificity (contact with other coronaviruses) are to be expected. studies on the serological reaction are not yet available for longer observation periods, but it can be assumed that positive direct detection of igg (anti sars-cv-2-elisa; euroimmun) is available at the latest 3 weeks after the onset of symptoms. without larger and representative analyses, it is currently unclear whether seroconversion is associated with permanent immunity or a lack of it leads to a possible susceptibility to reinfection. a combined test procedure is therefore to be offered to employees within the framework of a random sample. the query of anamnestic parameters allows the assignment to different groups (cc: past covid infection, pc: possible infection, n: asymptomatic). the primary goal of the planned study is to provide a first preliminary evaluation of the tests used in the current context.

Eligibility criteria:
inclusion criteria: * employees of the health facility described * voluntary request for testing exclusion criteria: - none

Keywords: seroprevalence covid-19
functional capacity and quality of life in patients with vascular ring

Conditions: Vascular Ring

Summary: to investigate the long term functional capacity and quality of life of patients with a history of vascular ring whether they did or did not have corrective surgery. patients will perform pulmonary function test, 6 minute walk test, cardiopulmonary exercise test and will fill a quality of life questionnaire.

vascular rings are congenital vascular anomalies of the aortic arch that compress the esophagus and the trachea. the most common vascular rings are double aortic arch and right aortic arch with left ligamentum. pulmonary artery sling is less common. another cause of tracheal compression occurring only in infants is the innominate artery compression syndrome. when patients are symptomatic, surgical correction should be performed. data regarding long term functional capacity and quality of life is lacking. our aim is to investigate the long term functional capacity and quality of life of patients with history of vascular ring whether they did or did not have corrective surgery. methods: a prospective study evaluating functional capacity and quality of life the patients will perform pulmonary function test, 6 minute walk test, cardiopulmonary exercise test and will fill a quality of life questionnaire (sf-36).

Eligibility criteria:
inclusion criteria: * patients with history of vascular ring exclusion criteria: * refusal to participate * inability to complete cardiopulmonary testing

Keywords: cardiopulmonary exercise testing, double aortic arch
study of arc1779 in patients with acute myocardial infarction undergoing pci

Conditions: Acute Myocardial Infarction

Summary: arc1779 is a novel drug being tested in patients undergoing angioplasty and stenting as their primary treatment for heart attack.

adjunctive anti-thrombotic therapy for pci of ami may be improved by incorporation of a novel anti-platelet therapeutic principle, von willebrand factor antagonism. arc1779 is a therapeutic oligonucleotide ("aptamer") which blocks the binding of the a1 domain of vwf to the platelet gpib receptor, and thereby modulates platelet adhesion, activation, and aggregation under the high shear conditions of coronary arterial stenosis and plaque rupture. this study is intended to provide dose-ranging and clinical proof of concept for arc1779 in a primary pci population.

Eligibility criteria:
inclusion criteria: * troponin-positive nstemi, with diagnostic symptoms and/or ecg abnormalities present within the preceding 24 hours, and a planned "early invasive" management strategy * stemi, with planned primary pci exclusion criteria: * history of bleeding diathesis or evidence of active abnormal bleeding within the previous 30 days * received treatment with fibrinolytic or gpiib/iiia antagonist drugs within the preceding 72 hours * received anticoagulant therapy with a low molecular weight heparin within the preceding 8 hours * severe hypertension (systolic blood pressure \>200 mmhg or diastolic blood pressure \>110 mmhg) not adequately controlled on antihypertensive therapy * major surgery or trauma within the preceding 6 weeks * history of stroke within 30 days or any history of hemorrhagic stroke * end-stage renal disease (esrd) with dependency on renal dialysis

Keywords: percutaneous coronary intervention
effects of individual, dyadic, and collaborative plans on physical activity in parent-child dyads

Conditions: Health Behavior

Summary: aims: the project aims at investigating of the effects of three types of planning (individual planning, collaborative planning, and dyadic planning) on physical activity.the influence of three planning interventions are compared with an active control condition, including physical activity education. participants: the effects of the interventions are evaluated among parent-child (aged 10-14) dyads, with a minimum of 50 dyads enrolled into the each arm of the trial (a total of 200 dyads). the interventions consist of six planning sessions. design: the dyads are randomly assigned to one of four experimental conditions. the assessment of the main and secondary outcomes is conducted at the baseline, at 1 week after the first intervention session, at post-intervention (after six intervention sessions are completed), and at 6-, and 12-month follow-ups. outcomes: physical activity constitutes the main outcome, whereas health-related quality of life (hrqol), body mass index, as well as the self-regulatory strategy called the use of planning (individual, dyadic and collaborative) are secondary outcomes.

individual planning (also known as implementation intentions or action and coping planning) is a regulatory strategy, which refers to making plans on when, where, and how to perform an intended behavior. in dyadic planning, a target person is setting plans together with a partner on when, where, and how the target person will individually engage in behavior change. the concept of dyadic planning differs from the conceptualization of collaborative plans, where two individuals make plans on how to enact a behavior together. the study will evaluate the effects of a short-term planning intervention. the intervention includes a total of six sessions: two face-to-face sessions with the experimenter (delivered over two weeks) and three sessions delivered over phone (over the following three weeks), one face-two-face session (delivered at one month after the third session delivered over the phone). the delivery has an individual format (the experimenter + the dyad). the total time from first to sixth session is 2 months. the setting for the interventions will include schools (school nurse office) or/and participant's home. the same format, schedule, delivery, and setting will be used for conducting active control group procedures.

Eligibility criteria:
inclusion criteria: * healthy children (age 10-14) and one healthy parents (any gender) or legal guardians * child or parent/legal guardian with chronic conditions but without contraindications for moderate intensity physical activity exclusion criteria: * children younger than 10 years old * parents who declared plans for changing residence during the following year (e.g., due to moving to another region of the country) * no parental consent at the baseline * no child consent at the baseline * existing diseases with contraindications for moderate intensity physical activity

Keywords: physical activity planning implementation intention quality of life body weight
patient perspective midline catheter in the emergency department

Conditions: Patient Satisfaction; Patient Preference

Summary: this study examines the patient satisfaction and perspective on the use of ultrasound guided midline intravenous catheters compared to standard ultrasound guided peripheral catheters.


Eligibility criteria:
inclusion criteria: * patient in the emergency department * failed 2 or more conventional attempts at vascular access \*or\* * history of requiring us guided vascular access * us fellowship trained physician available exclusion criteria: * basilic vein access is contraindicated * patient undergoing advanced resuscitation

Keywords: iv access ultrasound guided iv emergency care
advanced characterization of autosomal dominant optic atrophy

Conditions: Optic Atrophy, Autosomal Dominant

Summary: the purpose of this study is to determine the anatomy of the retina and the optic nerve in patients with autosomal dominant optic atrophy (adoa). based on these findings the aim of the study is to determine why patients with the same type of genetic material, i.e. the same mutation, have such large variations of symptoms, spanning from unaffected subjects to blindness. the project requires examination of both healthy and affected family members.


Eligibility criteria:
inclusion criteria: * subjects diagnosed with autosomal dominant optic atrophy exclusion criteria: * age below 8 years old
propranolol rescue of prolonged labor

Conditions: Pregnancy, Prolonged

Summary: a double-blind placebo controlled randomized trial comparing cesarean delivery rates in women given iv propranolol versus placebo for treatment of prolonged labor.

a double-blind placebo controlled randomized trial comparing cesarean delivery rates in 326 women given iv propranolol (2 mg with one possible repeat dose greater than 2 hours later) versus iv placebo for treatment of prolonged labor.

Eligibility criteria:
inclusion criteria: english-speaking \>= 36 weeks gestation singleton pregnancy vertex presentation no contraindication to a vaginal delivery meets at least one study criteria for prolonged labor: 1. cervical dilation \<6 cm after ≥8 hours with ruptured membranes and receiving oxytocin or 2. cervical dilation \>=6 cm and \<1 cm dilation change over ≥2 hours with ruptured membranes and receiving oxytocin exclusion criteria: severe preeclampsia: as patients will be receiving magnesium and possibly labetalol for hypertension control receiving other beta blocker maternal heart rate \< 70 beats per minute, systolic blood pressure \<90 mmhg, or diastolic blood pressure \<50 mmhg on two sets of vital signs in the 1 hour prior to study drug administration: given that bradycardia and hypotension are possible side effects of propranolol history of any form of asthma: as this is a contraindication to beta blocker use diabetes requiring insulin in labor: given the potential risk of neonatal hypoglycemia in the neonate any cardiac condition for which β blockade is contraindicated (cardiogenic shock, sinus bradycardia, and greater than first degree heart block) known hypersensitivity to propranolol intrauterine fetal demise since different labor protocols are used in these women major fetal congenital anomaly since rate of cesarean may be inherently different in these women, unrelated to labor

Keywords: propranolol cesarean
do bonding disruptions occur more often in children with asthma than in non-asthmatic populations?

Conditions: Asthma in Children; Anxiety

Summary: six studies have preceded this project. three studies suggested that there is a significant connection between pediatric asthma and disruptions in maternal-infant bonding (feinberg, 1988; schwartz, 1988; pennington, 1991). three studies suggested that children with asthma benefit from a type of therapy that improves bonding with their mothers (madrid, ames, skolek, \& brown, 2000; madrid, ames, horner, brown, \& navarrette, 2004; madrid, pennington, brown \& wolfe, 2011). this study proposes to study in a more thorough fashion the question of the incidence of bonding disruptions with between mothers and their children with asthma. this time there will be a larger sample, and more stringent criteria will used in assigning children to the asthma cohort. through questions answered by mothers whose children have been said to have asthma, we will be able to decide if the children's respiratory conditions are likely to be attributable to asthma or more likely reflective of another respiratory condition such as vocal cord dysfunction or anxiety related hyperventilation (anbar, 2014).


Eligibility criteria:
inclusion criteria: * biological mothers of male and female children between 2 and 12 years of age who live with or have contact with their children * english is the primary language of the biological mother exclusion criteria: * mothers of children only below 2 or above 12 years of age * mothers of children thought to have a chronic health condition other than asthma * mothers who have already completed a questionnaire with another child

Keywords: asthma maternal bonding maternal bonding disruptions mother-infant interaction
physical activity in hidradenitis suppurativa (hs)

Conditions: Hidradenitis Suppurativa

Summary: the purpose of the study is to characterize the challenges to physical activity and exercise for hs patients and design an exercise program (ep) with evidence-based techniques and examine its outcome.


Eligibility criteria:
inclusion criteria: * adults 18 years old to 80 years old * have diagnosis of hs confirmed by a dermatologist * able to provide informed consent * for the extended portion of the study: classified as having moderate-to-severe hs as per the ihs-4 criteria exclusion criteria: * individuals who are not yet adults * women known to be pregnant * prisoners * subjects, who in the opinion of the pi, cannot comply with the study procedures
improving safety by basic computerizing outpatient prescribing

Conditions: Adverse Drug Events

Summary: the study will measure the effect of basic clinical decision support on medical errors and adverse drug events in the ambulatory setting.


Eligibility criteria:
inclusion criteria: * provider practicing at sites implementing order entry with basic clinical decision support using either the longitudinal medical record (lmr) or medical gopher exclusion criteria: * provider or practice unwilling to participate

Keywords: adverse drug events medical errors computerized physician order entry clinical decision support
study to compare the blood levels of sildenafil following administration of an experimental tablet vs. the conventional oral tablet in healthy subjects.

Conditions: Erectile Dysfunction

Summary: this study to will compare the blood levels of sildenafil following administration of an experimental tablet vs. the conventional oral tablet.


Eligibility criteria:
inclusion criteria: healthy males between the ages of 18 and 55 years. body mass index of 18 to 30 kg/m2, and a total body weight \>50 kg (110 lbs). exclusion criteria: smoking in excess of the equivalent of 5 cigarettes per day. treatment with an experimental drug within 30 days or sildenafil, vardenafil, tadalfil within 4 days before first study dose. develop blood pressure lowering or experience dizziness, lightheadedness when going from the laying down position to standing position.