Kornimate/medical-research-clean huggingface dataset:
energy ct in imaging and diagnosis of gastric cancer

Conditions: Gastric Cancer; CT

Summary: accurate preoperative prediction of risk stratification, treatment response, and survival prognosis in gastric cancer is important for improving clinical treatment decisions, prolonging patient survival, and improving patient quality of life. the purpose of this study is to investigate the performance of the multi-parametric magnetic resonance imaging (mpmri) and dual-/muti-energy ct and photon-counting detector ct(pcd-ct) in the diagnosis and management of gastric cancer.


Eligibility criteria:
inclusion criteria: 1. pathological biopsy confirmed gastric cancer; 2. surgery: patients undergoing radical gastrectomy. patients undergoing exploratory abdominal surgery or palliative tumor resection were still included in the study when peritoneal metastasis or adjacent organ invasion was identified intraoperatively and radical surgical resection was not possible. exclusion criteria: 1. refusal or inability to sign informed consent; 2. ct or mri images are poor or the focus is small and ct images are not clear; 3. patients with other tumors complicated with patients with important organ dysfunction.

Keywords: ct gastric cancer
evaluation of two community based screening strategies for severe acute malnutrition in children 6-59 months in mirria district, niger

Conditions: Malnutrition

Summary: the objective of this study is to determine the efficacity of a community strategy for screening children 06-59 months old for severe acute malnutrition (sam) conducted by their mothers' compared with a community screening strategy conducted by community health workers.


Eligibility criteria:
inclusion criteria: * children aged 06-59 months at the time of the study * children who live in a village in the health district participating in the study exclusion criteria: * children whose legal guardian refuses to participate in the study

Keywords: screening malnutrition community management of acute malnutrition
cumulative fluids balance and ventilator associated events

Conditions: Ventilator Associated Event

Summary: fluid therapy is widely used to improve organ perfusion and survival in critically patients. fluid therapy is an important component of intensive care management; however, optimal fluid management is unknown. inadequate or excessive fluid resuscitation, on the other hand, is linked with a poor prognosis; the former can cause tissue hypo-perfusion and exacerbate organ dysfunction, while the latter can raise the risk of heart failure, pulmonary edema, and pleural effusions. ventilator-associated lung injury (vali) is a devastating complication of assisted mechanical ventilation (mv) and is one of the root causes of prolonged mv.

this study is designed to test the association between cumulative fluids balance and ventilator associated events among critically ill patients. setting: this research will be carried out in four general intensive care units at two hospitals in el beheira governorate, egypt. * for three months, from october 1, 2022 to january, 2023, all newly admitted mechanically ventilated patients who will fulfill the inclusion criteria and agree to participate will be screened on a daily basis. * the investigators will calculate cumulative fluid balance as daily fluid balance within four days of the event of interest. cumulative fluid balance will be computed as the sum of daily fluid balances over the previous 24 hours, calculated by total fluid input minus total fluid output on a specific day of icu admission over the first four calendar days of mechanical ventilation. insensible fluid loss, such as perspiration or evaporative water loss related to respiration will not be routinely assessed and will not be included in the calculation of cumulative fluid balance. the cumulative fluid balance from day 0 to day 1 will be labelled as day 1, and the following days as day 2 and day 3. cumulative fluid balance at day 3 refers to the cumulative fluid balance during the first four calendar days. * variables associated with vaes will be assessed for each patient including: age, gender, admission diagnosis, comorbidities; and icu length of stay, apach ii score, sofa score and duration of tracheal intubation.

Eligibility criteria:
inclusion criteria: * aged ≥18 years, * mechanically ventilated for ≥48 h and remain in the intensive care ≥4 days. exclusion criteria: * patients with acute renal failure and needs dialysis, * increasing daily minimum positive end-expiratory pressure (peep) or fio2 during mv treatment * hemodynamic instability

Keywords: cumulative fluids balance ventilator associated event critically ill patients
hypoalgesic effect of neural mobilization

Conditions: Cervicobrachial Neuralgia

Summary: the purpose of these study is to compare the effectivity of the cervical lateral glide physical therapy neural mobilization technique to the complete absence of treatment in a group of patients who suffer cervicobrachial pain.

the cervical lateral glide (clg) is a neural tissue mobilization technique capable of achieving a hypoalgesic effect during the onset of cervicobrachial pain symptoms. this happens through a series of complex physiologic interactions which are not fully understood. the clg physical therapy technique consists of controlled movements of the cervical and brachial plexus neural tissue. hypoalgesic effect produced by clg is associated to an increase in neural tissue mobility, edema, inflammation and intraneural pressure reduction, without any known side effects when applied properly, except for a momentary worsening of symptoms (the only known side effect of clg), which is an important contrast to the wide and sometimes severe spectrum of side effects derived from drug therapy used to treat cervicobrachial pain. it is believed that the hypoalgesic effect offered by neural tissue mobilization is a consequence of descending nervous system pain modulation activity and an improvement in the distinct biomechanical properties of the involved neural tissue.despite the increase in scientific interest in evidence based options to treat pain and neural tissue mobilization techniques there is a current lack of enough controlled double blind clinical trials that measure the effectiveness of neural tissue mobilization techniques such as the clg and its specific effect over cervicobrachial pain. for this reason the present investigation consisted in the application of a treatment protocol based on clg neural tissue mobilization in a controlled double blind clinical trial with the aim to assess its clinical effectiveness in treating pain symptoms

Eligibility criteria:
inclusion criteria: * clinical diagnosis of cervicobrachial pain confirmed by magnetic resonance imaging * presence of unilateral symptoms of arm pain, paresthesia or numbness in the upper extremity during at least 3 continuous months previous to the application of treatment. * positive results in all of the following tests: spurling, distraction, and upper limb exclusion criteria: * contraindication in the use of nonsteroidal anti inflammatory drugs (nsaids) * the use of any type of treatment, therapy, procedure or drug to relieve pain * patients who are under anticonvulsant, antidepressant or psychotropic medication * vertebral instability * vertebral osteoporosis * vertebral or spine infection. * neurologic diseases of genetic, infectious or neoplastic origin * cervical stenosis myelopathy * pregnancy * kinesiophobia * endocrine disorders and menopause * history of spine surgery * intellectual disability, severe mental illness, intoxication, severe sleep deprivation, alzheimer's disease.
effectiveness of gamified mobile health apps for airway clearance therapy in children and adolescents with cystic fibrosis

Conditions: Cystic Fibrosis (CF)

Summary: the aim of this randomized controlled trial is to evaluate the effectiveness of gamified mobile health (mhealth) applications for airway clearance therapy in children and adolescents with cystic fibrosis. primary outcomes include forced vital capacity (fvc), forced expiratory volume in the first second (fev₁), adherence to therapy, health-related quality of life (hrqol), and satisfaction with the intervention. the intervention will consist of 20-minute sessions, performed twice daily over a 24-week period. at least a total of 36 participants aged 8 to 18 years with cystic fibrosis will be randomly assigned to three equally sized groups: the experimental group (gamified mhealth apps: voice volume catcher, scream go hero, and chicken scream), the control group (conventional airway clearance techniques: autogenic drainage, active cycle of breathing techniques, and positive expiratory pressure therapy), and the mixed group (10 minutes of gamified mhealth apps combined with 10 minutes of conventional techniques). this study seeks to provide evidence on the feasibility and clinical benefits of integrating gamification into airway clearance therapy to improve respiratory outcomes and patient engagement in pediatric cystic fibrosis care.


Eligibility criteria:
* inclusion criteria: * population with cystic fibrosis (cf), aged 8-20 years. * individuals using or not using cftr modulators (e.g., kaftrio, kalydeco, etc.), regardless of their specific mutation. * exclusion criteria: * forced vital capacity (fvc) and/or forced expiratory volume in the first second (fev1) \< 40%. * oxygen therapy or continuous mechanical ventilation. * moderate hemoptysis or recent pneumothorax (within the past 3 months). * presence of an active, uncontrolled respiratory infection exacerbation that required hospitalization within the 30 days prior to the intervention. * other conditions such as neuromuscular disorders or cognitive difficulties (mini-mental state examination score \< 19 points).

Keywords: mhealth gamification mobile app adherence engagement motivation children adolescent randomized controlled trial
the svendborg-project

Conditions: Obesity, Childhood; Risk Factor, Cardiovascular; Sports Injury; Physical Activity; Motor Activity

Summary: the main aim of this study is to describe differences in development of health and motor performance over time in relation to type of school and other background variables.


Eligibility criteria:
inclusion criteria: * enrolled at school participating in study * grade 0 - 4 * written, informed consent provided by parent or legal guardian exclusion criteria:
complications of bladder augmentation in children

Conditions: Neurogenic Bladder Disorder; Spina Bifida; Complications of Surgical Procedures or Medical Care; Child, Only; Bladder Dysfunction

Summary: the goal of this observational study is to describe the complications in participants who underwent enterocystoplasty in childhood. the main question\[s\] it aims to answer are: * what kind of complications are there * the kind of complications depending on the type of enterocystoplasty participants data will be collected in the medical field. there is no comparison group.

from 1982 to 2020, all patients who had an enterocystoplasty in childhood were collected. complications were numbered depending on the type of enterocystoplasty and the investigators tried to find which risk factors exist.

Eligibility criteria:
inclusion criteria: * patients who underwent a enterocystoplasty before 18 years old exclusion criteria: * patients who underwent a enterocystoplasty after 18 years old

Keywords: bladder augmentation enterocystoplasty surgical complications child retrospective study
fertility in young adults who did (not) store testicular tissue before a treatment leading to fertility problems

Conditions: Childhood Cancer; Hematological Disorders

Summary: the goal of this prospective comparative interventional cohort study is to assess the fertility status of young adult men (≥18 years) who received gonadotoxic treatment during childhood for the treatment of cancer or hematological disorders. these treatment protocols are highly gonadotoxic (i.e. they may cause later fertility problems) and therefore these patients have been proposed to store some testicular tissue during childhood as an option to preserve their fertility. the main questions this study aims to answer are (1) the impact of the received gonadotoxic treatment on the later fertility status and (2) the additional impact of a testicular biopsy procedure (performed at a young age to harvest testicular tissue for storage) on the future fertility. participants will be asked to undergo a physical examination by a fertility specialist, to undergo a scrotal ultrasound, to give a blood sample, and to provide a semen sample. researchers will compare the patients fertility status between the different received gonadotoxic treatment protocols, between patients who underwent a testicular biopsy procedure at a young age and those who did not, and compare the patients fertility status with the reproductive health of spontaneously conceived young adults.

see the subsequent protocol sections.

Eligibility criteria:
inclusion criteria * young adult men (≥18 years) * diagnosis of cancer or hematological disorder during childhood (\<18 years) * high-risk gonadotoxic treatment received during childhood * at least one year after the last received genotoxic treatment * did/did not undergo a testicular biopsy procedure at a young age for fertility preservation exclusion criteria - prepubertal patients and adolescents (\<18 years)

Keywords: male fertility preservation testicular tissue biopsy male fertility status tanner stage testicular volume hormones semen analysis
neurotrophic factors and depression

Conditions: Depression

Summary: study intended to determine if there are baseline differences in serum neurosteroid levels and neurotrophic factor (bdnf) levels in healthy controls vs unmedicated depressed subjects, and whether the levels of these change with antidepressant treatment. study also intended to determine if baseline neurosteroid/ bdnf levels, and the change in these levels with =treatment, are correlated with clinical antidepressant response to escitalopram (lexapro).

the study was approved by the ucsf committee on human research, and all participants gave informed consent. the depressed subjects began treatment with placebo for one week, followed by escitalopram for eight weeks (10 mg per day x 4 weeks, followed by 20 mg per day x 4 weeks, as tolerated) in a double-blind, fixed-order, within-subject cross-over manner. the depressed subjects and the psychiatric rater were unaware of the study design and the sequence and duration of treatments. depressed and control subjects underwent venipuncture to obtain blood for assays. the controls underwent venipuncture once, and the depressed subjects had venipuncture just prior to beginning active escitalopram treatment and again after 8 weeks of escitalopram treatment. blood was also collected at weeks 4 and 8 of treatment in the depressed subjects for assay of citalopram and citalopram metabolites, to gauge medication compliance. finally, depression severity and global clinical change were assessed in the depressed subjects at baseline and at the end of week 8 of escitalopram treatment.

Eligibility criteria:
male subjects with unipolar major depressive disorder (dsm-iv) with a minimum score of 22 on the 10-item montgomery-åsberg depression rating scale (madrs) who were medication-free for at least 6 weeks, were enrolled. fifteen individually age-matched (+ 3 years) healthy male controls with no history of psychiatric illness were also enrolled. subjects' ages ranged from 22- 55 y.o. (mean + s.d.= 41.4 + 8.75 y.o.). all subjects were required to pass a urine toxicology screen (assessing the presence of drugs of abuse) on the day of testing. exclusion criteria: individuals with co-morbid panic disorder were excluded, since they may poorly tolerate typical starting doses of antidepressants , and individuals with co-morbid post-traumatic stress disorder were excluded, since they may have neuroendocrine regulatory responses different from those of depressed subjects without ptsd. exclusion criteria for both groups included recent (within 6 months) alcohol or drug abuse as defined by dsm-iv criteria, concurrent psychotherapeutic interventions, poor medical health or abnormal clinical labs, active suicidality, and use of medications that could interfere with the study.

Keywords: depression bdnf neurotrophic factor neurosetroid allopregnanolone
study to evaluate safety, tolerability and pharmacokinetics of cs0159 in chinese healthy subjects

Conditions: Primary Biliary Cholangitis

Summary: this is a phase i clinical bridging trial, randomized, double-blind, placebo-controlled, single ascending does/ mulelple ascending does study of cs0159 to evaluate the safety, tolerability, pharmacokynetics, pharmacodynamices, and food effect in chinese healthy subjects.


Eligibility criteria:
inclusion criteria: 1. healthy adult subjects of 18 years to 55 years. 2. weight: male≥50kg, female≥45kg bmi: 18\~32kg/m². 3. in good health, determined by having no clinically significant findings from medical history, physical examination, 12-lead ecg, vital signs measurements, and clinical laboratory evaluation. 4. subject signs ifc and dates and subject must understand and follow test procedures and restrictions. exclusion criteria: 1. subjects with special dietary requirements and cannot follow a uniform diet. 2. pregnant or nursing females or females who have pregnancy plans during the trial or within 3 months after the trial. 3. any subject with sars-cov-2 infection, based on a positive polymerase chain reaction for sars-cov-2. 4. history or evidence of clinically significant disorder, condition, or disease that, in the opinion of the investigator, would pose a risk to subject safety or interfere with the study evaluations, procedures, or completion.
study on hypertension and frailty in the older people

Conditions: Frailty; High Blood Pressure

Summary: to estimate the linear association between daytime systolic blood pressure variability evaluated as standard deviation (sd) and frailty evaluated as frailty index according to the rockwood's accumulation of deficits model


Eligibility criteria:
inclusion criteria: * diagnosis of hypertension according to the criteria of the european society of cardiology guidelines * consent of the patient (or legal representative) to participate in the study exclusion criteria: * refusal of the patient or his/her legal representative * life expectancy of less than 6 months
emergence of the covid 19 epidemic in the city of nice

Conditions: COVID

Summary: descriptive analysis of the appearance of the first cases of covid 19 diagnosed in the city of nice. analysis of the association of socio-demographic factors with the viremia attack rate according to the district of residence.


Eligibility criteria:
inclusion criteria: * people resident in city of nice at the covid diagnosis
the effect of gum chewing on postoperative ileus

Conditions: Perforated Appendicitis

Summary: the purpose of this study is to see if chewing gum after surgery for perforated appendicitis will shorten the time of intestinal dysfunction.

after operations for a ruptured appendix, children are usually not allowed to eat or drink anything. this is because the infection inside the abdomen and the manipulation of the intestines during the operation cause the bowels to stop their normal movement. the resulting lack of bowel function is called an "ileus". when this occurs, intestinal secretions and anything taken in by mouth can become backed up, causing bloating, abdominal pain, nausea and vomiting. children are not allowed to eat or drink anything during this time and require fluid hydration through an iv or even nutrition through an iv. this ileus usually lasts an average of 4-5 days, and can sometimes delay the discharge of children who are otherwise ready to go. the purpose of this research study is to determine if simple things, like gum chewing or anti-motion sickness bracelets can help speed the time it takes for the bowels to begin working after an operation for a ruptured appendix. because the gum is not swallowed, it does not have the same effects as eating and drinking would on someone with an ileus. the same is true for the anti-motion sickness bracelets. yet, it is thought that the chewing action from gum may stimulate the intestines into thinking that food is on the way and cause them to start working sooner than they otherwise might. the same may be true for the bracelets, and some studies show them to be helpful with nausea after surgery. nevertheless, the effects of a bracelet on postoperative ileus are unproven.

Eligibility criteria:
inclusion criteria: * any child who has undergone appendectomy for perforated appendicitis exclusion criteria: * age less than or equal to 5 years * unable to chew gum safely * interval appendectomy

Keywords: perforated appendicitis ruptured appendicitis acute appendicitis with perforation
the influence of vision on balance, gait and falls

Conditions: Cataract

Summary: falls are the most serious and frequent home accident amongst elderly. most falls occur during walking. vision is reduced with ageing and visual impairments affect balance. uncorrected visual deficits and balance problems are reported to be risk factors for falls and fall related fractures. the present project uses a longitudinal design and aims at assessing the impact of cataract surgery on balance and gait as risk factors for falls.

a longitudinal design is used, where subjects referred to the cataract unit are tested 1-3 weeks in advance of the surgery, and 4-6 weeks and 12 months after the surgery. outcome measures are visual function, falls, balance and gait. secondary outcome is quality of life, fear of falling and daily life functioning

Eligibility criteria:
inclusion criteria: * \>70 years of age * referred to cataract surgery on one or both eyes * able to walk unassisted at least 10 m exclusion criteria: * terminal illness * have undergone orthopedic surgery in the lower limbs the last 12 months * have had a stroke last 12 months * dementia (measured by mmse \<20

Keywords: effect balance gait falls
effect of 4-session metacognitive training in chinese adult outpatients with schizophrenia spectrum disorders and major depressive disorder

Conditions: Delusions; Depression

Summary: psychological studies have shown that individuals tend to attribute causes of positive and negative events differently. specifically, individuals hold an internalising or externalising bias of attribution which, in the case of particular patient groups, was found to polarize to the extreme. such extreme attributional styles have found to have a direct impact on emotions, leading to a waning course of psychiatric disorders. this project aims to further examine the theoretical links between attributions and emotions using a transdiagnostic approach, and the effect of a 4-session process-based intervention on attributional biases.


Eligibility criteria:
inclusion criteria: * aged 18-65 years * clinical diagnosis of non-organic psychosis or major depressive disorder * presentation of delusions/a moderate level of depression exclusion criteria: * clinical diagnosis of psychotic depression or depression with psychotic features * primary diagnosis of substance misuse or learning disability * participation of any cognitive/reasoning training program

Keywords: psychosis depression metacognition attribution emotions