Kornimate/medical-research-clean huggingface dataset:
the role of pkc activation in the immune-inflammatory mechanism of major depressive depression

Conditions: Major Depressive Disorder

Summary: major depressive disorder (mdd) is a heterogeneous mental illness. treated with antidepressants that act on the neurotransmitter and/or their receptors just remitted only one third of patients with mdd, thus, to improve the efficacy is a major unmet need for depression. based on the scientific reports, inflammation plays a definite role in the development and treatment of depression, which may be an important way to understand and finally solve the problem. our team found that there were significant changes in tumor necrosis factor (tnf)-α and other inflammatory factors in depressed patients, which caused neuronal apoptosis and depressive symptoms; prkcb1(gene of protein kinase c-β) plays an anti-inflammatory role by regulating protein kinase c(pkc) activation in specific brain region, improving neuroplasticity and playing an antidepressant role. in this study, we assumes that the treatment-resistant depression patients maybe due to the immune inflammation and pkc activation inconsistency or unsynchronized, which couldn't reversible microglia polarization and neuronal apoptosis in specific brain regions, then, caused the significant changes at emotional and cognitive neural circuits, so as to exhibit such as emotional, cognitive symptoms of depression. therefore, activating pkc and regulating immune/inflammatory process will be another way to improve the treatment outcome of depression. take consideration, we focus on treatment-resistant depression patients, to validate the relationship between pkc activation and the immune inflammatory mechanism of depression, evaluate the antidepressant effect of golimumab or calcium tablet (a pkc activator) plus escitalopram, and initially proposes idividualized treatment strategies for mdd.

this is a randomized, double blind, placebo-controlled antidepressant augmentation trial. all participants are randomly divided into 3 groups treated orally with "escitalopram + golimumab" (n = 60), "escitalopram + calcium tablet" (n = 60) or "escitalopram +placebo" (n = 60).

Eligibility criteria:
inclusion criteria: 1. healthy men or women of matched age, gender and education with that of treatment-resistant depression (trd) group; 2. a willingness to adhere to all prohibitions and restrictions necessary for the study; 3. signed informed consent. exclusion criteria: 1. participant who have severe mental diseases, physical diseases, cerebrovascular disease, or a history of traumatic brain injury; 2. participant who had a serious allergic reaction disease or those who have suffered from diseases of the immune system; 3. participant who used anti-inflammatory drugs, or immunomodulatory drugs no more than 1 month prior randomization; 4. pregnant or lactating female.

Keywords: major depressive disorder neuroimmunology protein kinase c
mechanically-assisted ventilation in the treatment of moving tumours with photon and proton therapies

Conditions: Thoracic Neoplasm; Liver Cancer; Ventilator Lung; Radiotherapy; Complications

Summary: mechanical ventilation can be used to impose a completely regular pattern of breathing frequency and inflation volume on the patient for as long as required. this would considerably improve the reproducibility of the internal motion parameters, and thus facilitate the implementation of respiratory-synchronized techniques such as gating, tracking and four-digital optimization.

this will be a three-phase analysis : first, different ventilation modes will be tested and compared on healthy volunteers. this phase will be analysed with a ventilator and with dynamic mri in order to measure the movement of anatomical structures in each ventilation mode (intra-fraction analysis). further, we will repeat these exams in order to compare them with the first ones, in order to analyse the reproducibility and baseline shifts (inter-fraction analysis). here are the different ventilation modes * spontaneous breathing * physiologic ventilation mode : * shallow ventilation mode * slow ventilation mode * jet ventilation mode second phase will be done with patients that are intended to have a radiation treatment for thoracic or upper abdominal tumors. all the previous ventilation modes will be analysed during repeated mri, again in order to perform intra- and inter-fraction analysis of the tumor motion. third phase also concerned patients intended to have a radiation treatment. it will be an in-silico-planning analysis in order to quantify dosimetric outcomes of these ventilation modes.

Eligibility criteria:
inclusion criteria: * no comorbidity for healthy volunteers * cancer patients with either lung or upper abdomen (liver/pancreas) tumours treated with radiation therapy. exclusion criteria: * severe lung disease or emphysema * previous history of pneumothorax * claustrophobia

Keywords: thoracic tumors motion management radiotherapy ventilator
effectiveness and neuropsychological predictors of guided self-help for obsessive-compulsive disorder (ocd)

Conditions: Obsessive-Compulsive Disorder

Summary: the primary aim of this study is to learn about who is most likely to benefit from guided self-help (gsh) for obsessive-compulsive disorder (ocd).

40 participants with ocd will be recruited. they will be given access to oc fighter, an internet ocd treatment program. during the 17 week program, participants will meet with a therapist 9 times. assessments will occur at pretreatment, post-treatment, 3-month follow up and 6-month follow up.

Eligibility criteria:
inclusion criteria: * principal or co-principal diagnosis of ocd * clinical global impression score greater than or equal to 4 * y-bocs score great than or equal to 8 * fluency in english * capacity to understand the nature of the study and willingness to sign informed consent form exclusion criteria: * active manic episode, psychosis, pervasive developmental disorder, mental retardation * concurrent ocd psychotherapy * current threat of harm to self or others * previous adequate trial of therapist-administered or self-administered exposure and response prevention for ocd
analysis of patient understanding of radiation therapy among patients with breast cancer

Conditions: Breast Cancer

Summary: the purpose of this study is to conduct a descriptive feasibility study of assessing how patients retain and understand information regarding radiation therapy obtained from an initial consult visit. this study will also pilot the use of visual aids and assess their utility to patients during a consult. the study will provide a baseline to conduct larger studies that will later incorporate additional patient education tools to assess changes in patient understanding of information received in radiation oncology patient consultations.


Eligibility criteria:
inclusion criteria: * patients 18 years or older with non-invasive or invasive breast cancer receiving consultation at the breast radiation oncology clinic for radiotherapy recommendations exclusion criteria: * patients under 18 years old or receiving palliative care
effects of using divided mesh and using a non divided mesh on testicular blood flow and volume in laparoscopic hernia repair

Conditions: Hernia, Inguinal

Summary: laparoscopic inguinal hernia repair techniques has been compared with the open techniques in several studies. however, no one studied about the different uses of the same type of mesh on the same surgical technique, and effects of this different use on testicular volume and blood flow. the objective of this study is to investigate the effects at 6 months of the divided and non divided mesh in laparoscopic totally extraperitoneal hernia repair technique on testicular volume and blood flow by use of doppler ultrasonography


Eligibility criteria:
inclusion criteria: patients with unilateral inguinal hernia male patients - exclusion criteria: patients have femoral hernia patients have bilateral inguinal hernia patients have recurrent inguinal hernia female patients patients with history of pelvic surgery patients with history of pelvic major trauma patients with history of pelvic radiotherapy patients have previous scrotal trauma or surgery history patients have heavy cardiac diseases, pulmonary diseases patients have benign prostate hyperplasia patients have history of incarceration of inguinal hernia -
mitigating pain following refractive surgery

Conditions: Pain

Summary: using contact lens following refractive procedure to reduce pain.

patients at day 1 following the procedure will be treated with a contact lens and assessed for pain at 1,2,4 hours and 1,3,5 days. prospective comparative study

Eligibility criteria:
inclusion criteria: 1. patients who underwent bilateral refractive surgery for myopic correction. 2. age 18-60. 3. evidence of an epithelial defect. 4. patient complains of significant pain. 5. patients able to understand the requirements of the study and willing to follow study instructions, to provide written informed consent to participate, and who agree to comply with all study requirements, including the required study follow-up visits. exclusion criteria: 1. any other anterior segment abnormality other than that associated with refractive surgery. 2. any abnormalities associated with the eye lids. 3. prior laser treatment of the retina. 4. any ophthalmic surgery performed within three (3) months prior to study excluding refractive surgery. 5. diagnosis of glaucoma. 6. active diabetic retinopathy. 7. clinically significant inflammation or infection within six (6) months prior to study. 8. uncontrolled systemic disease (e.g., diabetes, hypertension, etc.) in the opinion of the investigator. 9. participation in any study involving an investigational drug within the past 30 calendar days, or ongoing participation in a study with an investigational material. 10. intolerance or hypersensitivity to topical anesthetics, 11. specifically known intolerance or hypersensitivity to contact lenses. 12. a medical condition, serious intercurrent illness, or extenuating circumstance that would significantly decrease study compliance, including all prescribed follow-up. 13. any condition that, in the opinion of the investigator, would jeopardize the safety of the patient.

Keywords: refractive surgery
antenatal covid 19 vaccination and pregnancy outcomes

Conditions: Effect of Drug

Summary: effect of covid 19 vaccinations on pregnancy outcomes must be clear and identified to detect their safty

in this study we will discuss side effects of covid 19 vaccine on pregnant women including the incidence of miscarrage , intrauterine fetal deaths, liquor abnormalities, preeclampsia, accidental hemorrhage , we also will follow up pregnant women who received any type of covid 19 vaccine till delivery and discuss the effect of the vaccine on fetus and newborn

Eligibility criteria:
inclusion criteria: * pregnant women aged 18 years or older who received any type of covid 19 vaccine during current pregnancy exclusion criteria: * comorbidities,women who refused participqtion,pregnant women with previous covid 19 infection during current pregnancy
non-blinded data collection study of concussion using the brainpulse(tm)

Conditions: Brain Concussion; Mild Traumatic Brain Injury

Summary: the multi-center study evaluates brainpulse recordings from subjects with a suspected or confirmed concussion to improve a concussion detection algorithm. subjects may also consent for a 5 additional follow-ups over a 21-day period to compare the progression of change in their brainpulse recordings.

the primary objective of this study is to collect un-blinded brainpulse recordings from youth and adults that have a confirmed diagnosis of concussion per protocol guidelines in order to improve a concussion detection algorithm previously developed by jan medical, inc. in order to gather sufficient variability, subjects with both confirmed concussion and suspected concussion will be included in the study as long as they meet eligibility criteria. brainpulse recordings from subjects with suspected concussion will be compared to the recordings of subjects diagnosed with concussion. subjects will be followed for 21 days after the initial injury with brainpulse recordings to study the subject's recovery process. the symptomatic evaluation, physical examination, and brainpulse recordings will be entered in a database to assess clinical outcome and device utilization.

Eligibility criteria:
inclusion criteria: 1. age \>= 5 years old 2. suspected or confirmed concussion by medical professional 3. not more than 3 days since injury/trauma event 4. willing and able to participate in all required study evaluations and allow access to medical testing and records 5. signed informed consent/assent, and/or have a legally authorized representative willing to provide informed consent on behalf of the subject 6. demonstrates a minimum of 3 of the following symptoms: * headache * pressure in head * dizziness * neck pain * fatigue/ low energy * nausea or vomiting * irritability * difficulty in concentrating/performing tasks * memory impairment * insomnia * reduced tolerance to stress * sensitivity to light * difficulty balancing * blurred vision * confusion * more emotional than usual * sadness * nervous/anxious * vacant stare * delayed verbal/motor response * 'feeling like in a fog' * 'don't feel right' exclusion criteria: 1. wound or open laceration on the head in the area of one of the brainpulse sensors that would impede use of the brainpulse device 2. any serious medical condition that in the opinion of the medical professional would impair ability to provide informed consent/assent or otherwise disqualify a patient from participation 3. currently participating in or planning to participate in another clinical study during the course of the current clinical study 4. implantation of any medical device in head (e.g. ventriculoperitoneal shunt)
music listening for cataract surgery

Conditions: Cataract Surgery

Summary: the purpose of the study is to assess the effect of music therapy on anxiety and hypertension during cataract surgery procedures performed under topical anaesthesia.

cataract surgery is the most frequent surgical procedure performed in europe, usually done under topical anaesthesia. restlessness and hypertension are the most frequent medical complications during surgery, potentially leading to surgical complications. since the surgery is ambulatory and requires the patient's cooperation, heavy intravenous sedation should be avoided. however, this procedure is stressful, with patients experiencing high anxiety due to being awake and aware of the procedure on their eye and equipment. music therapy may be considered as a non-pharmacologic and non-invasive mean to reduce anxiety and therefore intra-operative hypertension. to assess the effect of music therapy on anxiety and hypertension during cataract surgery procedures under topical anaesthesia, investigators intend to perform a randomized controlled trial. depending on the results of the study, music therapy may subsequently be replacing the usual premedication before surgery.

Eligibility criteria:
inclusion criteria: * patients undergoing elective cataract surgery performed under topical anaesthesia exclusion criteria: * non topical anaesthesia * non ambulatory surgery * communication difficulties including language barrier, and mental disorders * age\<18yo * hearing impairment * uncontrolled hypertension

Keywords: music cataract surgery topical anaesthesia anxiety hypertension
e-support for healthcare processes - weight loss

Conditions: Obesity

Summary: the purpose of the study is to establish and clinically evaluate a new approach to treating obesity by using information and communication technologies (ict). a mobile environment and organizational interventions to improve the process of an integrated treatment of people with obesity will be identified, developed, introduced and clinically evaluated.

a mobile environment to improve the process of an integrated treatment of obese people will be identified, developed, introduced and clinically evaluated. the study will include 150 patients aged between 25 to 65 for men and 25 to 70 for women, diagnosed with obesity (bmi≥30 or bmi\>27,5 and 20% risk or more for developing a cardiovascular diseases). one group of patients will visit conventional live workshops for weight loss and the other group will use ict. at the initial examination by the doctor all survey participants will have measured blood pressure, body mass, waist circumference, percentage of body fat, percentage of skeletal muscle, resting metabolic rate, estimated risk of developing cardiovascular disease and will be directed to laboratory examination (blood lipids and cholesterol, blood sugar). both groups will go through 16 workshops for weight loss. each week they will monitor their body mass, waist circumference, physical activity (type, duration, intensity) and food intake (type, quantity). after six months all survey participants will be examined again. we will compare effectiveness of ict weight loss group with conventional weight loss group.

Eligibility criteria:
inclusion criteria: * bmi≥30 or bmi\>27,5 and 20% or more risk for developing a cardiovascular diseases * age between 25 - 65 years for men and 25 - 70 years for women * own a mobile phone * internet * know how to use a computer * know how to use an e-mail * signed voluntary consent to participate in the survey exclusion criteria: * people with movement disorders * age\ 70 years for women and 65 years for men * pregnancy, breast feeding, intention of getting pregnant during the study, period after childbirth (9 months) * does not own or know how to handle a mobile phone * no internet access * known hospitalization for severe psychiatric disorders (schizophrenia, psychosis) * known history of eating disorders (anorexia, bulimia nervosa and others) * cancer incidence in the last 5 years * heart problems, chest pain, nausea, dizziness * chronic inflammatory diseases * other unregulated chronic diseases
the effect of iloprost on capillary recruitment and insulin sensitivity in type 2 diabetes

Conditions: Diabetes Mellitus, Type 2; Insulin Sensitivity/Resistance

Summary: this study examines the effects of iloprost - a stable prostacyclin analogue - on insulin-mediated muscle capillary recruitment and whole-body glucose uptake in a cross-over design.

in type 2 diabetes impaired insulin-mediated muscle perfusion is thought to contribute to reduced whole-body glucose uptake. this study aims to identify iloprost - a stable prostacyclin analogue - as a possible therapeutic option to increase whole-body glucose uptake via enhancement of muscle perfusion. all participants will be subjected to two hyperinsulinemic-euglycemic clamps; one with and one without simultaneous iloprost infusion in a randomized cross-over design. microvascular blood volume will be measured by means of contrast-enhanced ultrasonography.

Eligibility criteria:
inclusion criteria: * type 2 diabetes * male or female (post-menopausal) * age above 45 years and below 70 years * bmi \>30 kg/m2 * hba1c \< 80 mmol/mol or \< 8,6% subjects must use metformin * stable medication use * stable tension regulation (with or without medication) * subjects should be able to give informed consent exclusion criteria: * a history of cardiovascular event (cerebrovascular event, myocardial infarction or pacemaker implantation) * severe-very severe lung emphysema (gold stage iii-iv) * use of any antibiotics or proton pump inhibitor (ppi) in the past three months * use of any other antidiabetic medication besides metformin (e.g. su-derivates, insulin) * use of a platelet inhibitor or cumarin derivate during * subjects participated in a lifestyle programme in the past 6 months (diet or exercise)

Keywords: capillary recruitment
open label extension study evaluating safety and tolerability of aab-003 (pf-05236812) in subject with mild to moderate alzheimer's disease

Conditions: Alzheimer's Disease

Summary: this is a study to evaluate the safety and tolerability of multiple doses of aab-003 (pf-05236812) in patients with mild to moderate alzheimer's disease. patients who complete study b2601001 may participate in this trial and receive aab-003 (pf-05236812). each patient's participation will last approximately 52 weeks.


Eligibility criteria:
inclusion criteria: * successful completion of study b2601001 * mmse 12 or greater exclusion criteria: * study b2601001 week 32 mri with clinically important exclusionary findings. * experienced sae, vasogenic edema and/or intracranial hemorrhage in study b2601001

Keywords: randomized safety study open label
radioprotective effect of chinese herbal medicine on oral mucositis

Conditions: Head and Neck Cancer; Oral Mucositis

Summary: this protocol describes a randomized, double-arm, parallel-group, open-label controlled study that aims to evaluate the efficacy of chinese herbal medicine on head and neck cancer patients with oral mucositis toxicities and quality of life during radiotherapy.

200 head and neck cancer patients who were scheduled for radiotherapy are randomly assigned at a 1:1 ratio to two arms: control group and those treated with zi-yin-liang-ge-san containing rx. scutellariae, rx. glycyrrhizae, hb. dendrobii, rx. ophiopogonis, and hb. menthae haplocalycis from day 1 of radiotherapy. the study lasted at least 6 weeks and the clinical benefit was determined by onset, gradation of mucositis (common terminology criteria for adverse events v5.0), oral pain (visual analysis scale) for each week during rt. nutritional status, eortc quality of life core questionnaire (qlq-c30) and head and neck module (qlq-h\&n35), body constitution questionnaire (bcq), and electrical body conductivity were evaluated before and after radiotherapy. patient-reported outcomes version of common terminology criteria for adverse events (pro-ctcae), serious adverse events, blood and biochemical analysis will be recorded to evaluate the safety.

Eligibility criteria:
inclusion criteria: * histologically proven stage ii-iv squamous hnc * indication for radiotherapy or radio-chemotherapy * no history of antitumor therapies * no history of oral ulcer and salivary gland diseases * normal vital signs (body temperature: 36 to 37.5∘c, heart rate: 60 to 100 beats per minute, respiratory rate: \<20 per minute, and mean arterial pressure: 70 to 100mmhg), and eastern cooperative oncology group (ecog) performance status of 0 to 2 exclusion criteria: * terminal cancer for which aggressive treatments were not suitable * impaired renal or hepatic function at initial diagnosis (including chronic kidney disease stages iii, iv, and v and aspartate transaminase (ast), alanine aminotransferase (alt) ≥5 × the upper normal limit) * uncontrolled psychiatric problems or altered mental status * had received medications for other clinical trials

Keywords: oral mucositis radiotherapy head and neck cancer chinese herbal medicine randomized trial
study of 99mtc-sestamibi spect/ct imaging for the preoperative diagnosis of renal oncocytoma

Conditions: Clinical T1 Renal Mass

Summary: the objective of this study is to investigate the utility of 99mtc-sestamibi spect/ct imaging for the diagnosis of renal oncocytomas.


Eligibility criteria:
inclusion criteria: * presence of a solid enhancing ct1 renal mass detected on cross-sectional imaging * scheduled to undergo surgery with either partial or radical nephrectomy * age ≥18 years exclusion criteria: * pregnancy * evidence of nodal or distant metastases * history of other malignancy with concern for renal metastasis * known allergy to technetium or sestamibi