Kornimate/medical-research-clean huggingface dataset:
acute necrotizing pancreatitis and infected pancreatic necrosis

Conditions: Acute Necrotizing Pancreatitis

Summary: acute necrotizing pancreatitis is a frequent and potentially lethal disease, especially in case of infected pancreatic necrosis (ipn). ipn usually occurs after the first week of evolution. the step up approach is now widely recommended for the management of ipn. in fact, in case of suspicion of ipn, a drainage percutaneous or transgastric is recommended at first, supported by probabilist antibiotherapy. 1/3 of patients won't require any other interventions. for 2/3 of patients, an additional necrosectomy is necessary. necrosectomy was formally realized by open laparotomy. since de last decade, mini-invasive technics have emerged: transgastric necrosectomy, video-assist retroperitoneal debridement. laparoscopy and permitted a decreased of morbidity and mortality. recently, hollemans et al. developed a nomogram based on 4 variables (sex, multi-organ failure, % of necrosis and collections heterogeneity) which are negative predictors for success of catheter drainage in ipn with an receiver operating characteristic (roc) curve at 0.76. the aim of this study is to validate on a large retrospective cohort hollemans nomogram in predicting catheter drainage success. secondary aims are to evaluate possible others predictors for success of catheter drainage in ipn and to evaluate the impact of antibiotherapy on microbiological results and on the need for an additional necrosectomy regarding its type and duration, as well as the emergence of multiresistance organism.

using electronic patient data monitoring systems, the investigators reviewed all patients with a diagnosis of acute necrotizing pancreatitis admitted to digestive liver disease unity or icus at the nantes university hospital, rennes, angers and brest university hospital from january 1, 2012, to december 31, 2017. for enrolled patients, general clinical characteristics were collected. patients were categorized into two groups according to success of catheter drainage or failure of catheter drainage, and the differences of these characteristics between two groups were evaluated. the hollemans nomogram is evaluate and potential risk factors will be collected and studied by using multiple logistic regression analysis.

Eligibility criteria:
inclusion criteria: * adult patients (age \>18 years) with acute necrotizing pancreatitis * ipn proven or highly suspected (proven=positive cultures on pancreatic collections or gas on ct, highly suspected= sepsis without any others infection) * the need for a catheter drainage non inclusion criteria: * patients under 18 years * lack of radiologic evidence to diagnose acute necrotizing pancreatitis, * no suspicion or confirmation of ipn * no need for a drainage * unable to receive a drainage * pregnancy

Keywords: acute necrotizing pancreatitis acute pancreatitis pancreas disease sepsis infection drainage catheters antibiotics multiresistant organism
training parenting self-efficacy in parents of hospitalized preterm neonates

Conditions: Parenting; Preterm Infants; Training Support

Summary: in a hospital environment, initial parenting of a family with a preterm neonate will be very different than expected. this unusual and stressful situation may determine the self-confidence perceived by mothers and fathers in caring their baby and therefore could shape future interaction with him/her as well as neurodevelopmental and behavioral development of preterm infants. 24/7 neonatal units allow parents stay with their baby whenever they want but this free access nor guarantee neither encourage parenting self-efficacy if it isn't hand in hand with a specific training program for parents.

longitudinal, prospective, analytic cohort study of parents of preterm newborns who will receive a specific training program for caring their preterm newborns during hospitalization. families will be recruited during the first 10 days of hospitalization. the pmp s-e (perceived maternal parenting self- efficacy) tool developed by barnes and adamson-macedo, will be used to measure self-efficacy in providing infant care by mother or both mother and father. the training program will be developed at bed side by nurses and neonatologist covering theoretical and practical sessions during the first 25 days of hospitalization. hypothesis principal: parents of hospitalized preterm neonates will get better score after application of a specific training program (cap-prem). secondary hypothesis: * there is a correlation between the level of stress and anxiety in parents at admission and discharge and the results of pmp s-e score after the cap-prem program * to assess those selected demographic variables that can predict a better result in pmp s-e score after the cap-prem program

Eligibility criteria:
inclusion criteria: * preterm infants between 25 and 32 weeks of gestation, * parents stay at the unit for at least 8 hours/day during training program * fluent spanish. * parents age \> 18 years * no clinical instability, invasive mechanical ventilation, intraventricular hemorrhage \>ii or necrotizing enterocolitis . * no congenital malformation nor chromosomal abnormalities exclusion criteria : * no possibility of survival beyond the first week of life * admission less than 4 weeks * no collaboration / lack of parental compliance * wish of parents to leave the study

Keywords: parenting self-efficacy parent training program perceived self-efficacy tool
reducing mortality in adults with advanced hiv disease (revive)

Conditions: HIV Disease Progression

Summary: a double blinded, placebo-controlled, multicenter trial to evaluate effectiveness of azithromycin prophylaxis on mortality in advanced hiv.

all participants in the revive trial will be randomized (1:1) at the time of study entry to receive azithromycin prophylaxis or placebo for 28 days and will be followed for 24 weeks to determine the primary outcome measure. total follow up duration will be 48 weeks.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years 2. documented hiv infection 3. cd4 count criteria: i. cd4 count ≤ 100 cells/mm3 within past 4 weeks; or ii. documented cd4 nadir ≤ 100 cells/mm3 and complete interruption of art for ≥ 6 months; or iii. documented cd4 count ≤ 100 cells/mm3 if art-naive 4. ability to initiate or re-initiate art, or switch to an effective art regimen if failing current therapy, within 4 weeks of enrolment exclusion criteria: 1. contraindications to azithromycin: i. hypersensitivity to azithromycin, erythromycin, or any macrolide antibiotic; or ii. personal or family history of qt-prolongation 2. severe illness requiring immediate or continued hospitalization (this will be in the judgment of site investigators) 3. off-label azithromycin prophylaxis or requirement for prolonged (\> 7 days) azithromycin (or macrolide) therapy

Keywords: human immunodeficiency virus antiretroviral therapy azithromycin mortality
stony brook medicine anti-inflammatory trial

Conditions: Major Depressive Disorder

Summary: this is an experimental study designed to measure the effect of celecoxib or minocycline on depressive symptoms in unipolar and bipolar depression. participants will be equally randomized to either celecoxib or minocycline. all participants will complete a battery of clinical and psychological assessments prior to treatment assignment, and again after treatment completion, to assess any changes or improvements in depression.


Eligibility criteria:
inclusion criteria: * current consent form signed * capacity to give informed consent * age range 18-65 (inclusive) * diagnosis of mdd or bipolar depression and currently in a major depressive episode * score of at least 29 on the madrs (at least moderate depression) exclusion criteria: * hypersensitivity to celecoxib, minocycline, tetracyclines, sulfonamides, aspirin, other nsaids, or any component of the formulation; previous asthma, urticaria, or allergic-type reactions after taking aspirin or other nsaids * history of myocardial infarction or current cardiac condition * heptic impairment, heart failure, severe renal impairment, recent gi bleed, history of peptic ulcer disease, anemia or any other contraindication for celecoxib or minocycline * poor cyp2c9 metabolizer * currently taking medications that interact with celecoxib (digoxin, antihypertensives, diuretics, anticoagulant or anti-platelet treatment, including aspirin), or minocycline (isotretinoin, ergot alkaloids) without providing physicians approval * use of herbs, drugs, or medications with anti-inflammatory or immunomodulatory properties (within 5 half-lives of starting celecoxib or minocycline treatment) * unlikely to tolerate medication washout or the medication-free period following washout. * participant considered at significant risk for suicide. * electroconvulsive therapy (ect) within 1 month * high potential for excessive drug/alcohol use during the treatment period (excluding nicotine or cannabis) * significant active physical illness or neurological deficit that may affect brain functioning. * if participant is currently pregnant, breastfeeding, or planning to conceive during the course of study participation. * need for medications that control mania.
immunotherapy of hepatocellular carcinoma with gamma delta t cells

Conditions: Hepatocellular Carcinoma

Summary: for most patients with hepatocellular carcinoma, surgery or other curative procedures are not possible and only palliative measures could be applied (chemoembolization, targeted drugs, best supportive cares, etc). in the icar study, increasing doses of a cell therapy product will be evaluated in patients in a palliative setting. all patients will have one hepatic intra-arterial injection of immunological cells (gamma-delta t lymphocytes) and will be evaluated for safety.


Eligibility criteria:
inclusion criteria: * adult over 18 * hepatocellular carcinoma histologically proven, with at least one measurable tumor * non operable tumor * alfa foeto protein \> 400 ng/ml * other treatments (surgery, chemoembolization) non indicated * chemoembolization non indicated due to good performance status (who 1) or to tumor volume * performance status who \< 2 * life expectancy \> 3 months non inclusion criteria: * extra hepatic metastases * severe hepatopathy (child b or c) * virus b or c chronic hepatitis * chronic cardiac failure * uncontrolled severe infectious disease * other cancer, if not considered as cured * positive serology for hiv or htlv * leucocytes \< 3000/mm3 or neutrophils \< 1500/mm3 * platelets \< 80000/mm3 * serum creatinine \> 110 µmol/l * bilirubin \> 35 µmol/l * ast, alt, alkaline phosphatase \> 5n * current immunosuppressive treatment * impossibility to comply with scheduled follow-up * anatomical situation not permitting the selective injection of the product of cell therapy * pregnant or breastfeeding woman, or not using adequate effective contraceptive method exclusion criterion: * insufficient number of gamma delta lymphocytes after expansion

Keywords: cell therapy t lymphocytes hepatic intra-arterial injection
efficacy study of a ginger and cardamom gelatin for xerostomy in terminally ill patients

Conditions: Xerostomia; Salivary Gland Diseases; Mouth Diseases

Summary: xerostomia or dry mouth is the subjective feeling that there is not enough saliva in your mouth. it's a frequent symptom in terminally ill patients receiving palliative care, reducing their quality of life and comfort. usual recommendations in these patients are good oral hygiene and mouthwashes, ad libitum consumption of camomile and lemon juice infusions, and ad libitum sucking of cold (e.g. ice, ice cream) or citric products (e.g. pineapple). other xerostomia treatments such as artificial saliva and pharmacological drugs (e.g. pilocarpine) are less used in terminally ill patients due to cost and secondary effects. the purpose of this randomized parallel clinical trial is to determine if a new recipe of gelatin with orange juice, cardamome and ginger is more effective in the control of xerostomia than the usual treatment of camomile infusion with lemon juice against. treatments will be consumed ad libitum during one week. the main outcome is the subjective assessment of dry mouth at end of treatment.


Eligibility criteria:
inclusion criteria: * 18 years or older * receiving palliative care for terminall illness at mutuam pades * complaining of dry mouth and should not have been treated for this problem * able to prepare the study supplemental products by himself/herself or having a personal carer willing to do so exclusion criteria: * disease of oral mucosa (e.g. oral mycosis, coated oral cavity ). * oropharinx neoplasm treated with surgery or radiotherapy. * severe cognitive impairment (more than 7 errors in pfeiffer scale) * motor dysphagia causing coordination problems in swallowing. * life expectancy less than seven days (last days situation).
effect of positive expiratory pressure on the management of chest trauma

Conditions: Thoracic Fracture

Summary: chest trauma (ct) are a common problem in our environment caused mainly by traffic accidents and causal and domestic accidents among the elderly population. cts, in some situations, can lead to sequelae such as fibrothorax secondary to hemothorax and / or empyema and residual chronic pain. clinical regulations and guidelines recommend a guideline for chest physiotherapy (cp) for all patients with rib fractures, but there is little scientific evidence. it would be interesting to establish cp treatment protocols and describe the most appropriate techniques according to the type and stages of thoracic trauma consolidation. objective: to evaluate the effect of positive expiratory pressure (pep) breathing added to conventional cp in terms of aid secretion clearance, pain control, pleuropulmonary radiological abnormalities, restoration of lung function, and admission days in the immediate phase of the ct.

after acceptance to participate in the study, patients will be computerized randomized into 2 groups: * pep group: positive expiratory pressure breathing. * control group: conventional cp treatment without positive pressure brething. the period between day 0 and 20 days post-trauma is considered an immediate phase of ct. once admitted, an initial evaluation by the doctor will be performed, and pleuro-pulmonary complications, the presence of respiratory failure, and pain control will be evaluated. the chest physiotherapist will perform a clinical and secretion assessment using the seva test and a dynamic costal examination. the medical treatment of pain control will begin, and the treatment of cp will begin, where it will be randomized in 2 groups: 1- pep group: positive expiratory pressure breathing with the help of a pep bottle device. 2-control group: conventional cp treatment without positive pressure breathing will be daily fr sessions, on weekdays. upon admission, hospital discharge and post-discharge, radiological checks (simple radiography) will be performed and forced vital capacity will be measured with forced spirometry.

Eligibility criteria:
inclusion criteria: * chest trauma with three or more rib fractures with or without hemopneumothorax * failure to meet any exclusion criteria exclusion criteria: * non-cooperative patients for not understanding chest physiotherapy techniques. * presence of respiratory failure on admission: pao2 \ 50mmhg. * medical indication for mechanical ventilation or non-invasive ventilatory support. * presence of undrained pneumothorax. * complications that limit early mobility.
a phase 1, first time in humans study of nst-1024

Conditions: Hypertriglyceridemia

Summary: a first time in man study of nst-1024

a phase 1, first time in man study to evaluate the safety, tolerability, and pharmacokinetics of nst-1024 in healthy subjects and otherwise healthy subjects with elevated triglycerides. this will be a double-blind, randomised, placebo-controlled, single and multiple oral dose study conducted in 2 parts. in part a up to 6 cohorts of 8 healthy volunteers will receive single ascending doses of nst-1024 or matching placebo. i part b up to 4 cohorts of 10 otherwise healthy volunteers, with elevated triglycerides will receive daily multiple ascending doses of nst-1024 for 14 days

Eligibility criteria:
inclusion criteria: * bmi 18-32 kg/m2 * in good health * females will not be pregnant or lactating. females of childbearing potential must agree to use contraception * male subjects must agree to use contraception and refrain from donation of sperm * able to comprehend and willing to sign an icf and to abide by the study restrictions. * subjects must have tg levels \> 150 mg/dl at screening (part b only). exclusion criteria: * significant history or clinical manifestation of any metabolic, allergic, dermatological, hepatic, renal, haematological, pulmonary, cv, gastrointestinal, neurological, respiratory, endocrine, or psychiatric disorder, as determined by the investigator (or designee). * history of febrile illness within 7 days prior to the first dose of study drug or subjects with evidence of active infection. * history of stomach or intestinal surgery or resection that would potentially alter absorption and/or excretion of orally administered drugs (uncomplicated appendectomy and hernia repair will be allowed). * aspartate aminotransferase, alt, ggt, alp, or total bilirubin \> 1.2 × uln at screening or (first) check-in, confirmed by 1 repeat if necessary * history of alcoholism or drug/chemical abuse within 2 years prior to check-in. * participation in a clinical study involving administration of an investigational drug (new chemical entity) in the past 90 days or 5 half-lives (whichever is longer) prior to dosing. * use of tobacco- or nicotine-containing products within 1 month prior to screening, or positive cotinine test at screening or check-in.
examining of occupational balance, executive functions, and quality of life of adolescents with internet gaming disorder

Conditions: Internet Addiction Disorder

Summary: internet gaming disorder leads to social problems and isolation, neglect of daily responsibilities, behavioral disorders, and cognitive and physical impairments. it is thought that assessing the occupational profiles and cognitive functions of adolescents with internet gaming disorder will bring a new perspective to the occupational therapy literature. the aim of the present study is to examine the occupational balance, executive functions, and quality of life of adolescents with internet gaming disorder.

the study, planned to be conducted with individuals aged 12-18 who are followed up in the child and adolescent mental health and diseases outpatient clinic of bezmialem vakif university and diagnosed with internet gaming disorder according to dsm-v diagnostic criteria, will include a total of 62 participants, with 31 in the study group and 31 in the healthy control group. all individuals who provide written consent will be administered the sociodemographic data form, internet gaming disorder scale, teenage executive function inventory, pediatric quality of life inventory-adolescent form, and adolescent occupational balance scale, and the results will be recorded. the obtained results will be statistically analyzed.

Eligibility criteria:
inclusion criteria: * diagnosed with internet gaming disorder * aged between 12 and 18 * proficiency in turkish * open to communication and cooperation * willing to participate in the study * no reported cognitive impairment exclusion criteria: * additional psychiatric diagnosis * having a neurological problem that would impair communication and collaboration

Keywords: addiction executive functions internet gaming disorder occupational balance quality of life
randomized, controlled study on short-term psychotherapy after acute myocardial infarction

Conditions: Acute Myocardial Infarction

Summary: psychosocial factors play an important role in the pathophysiology of acute myocardial infarction (ami), but it is not known if psychotherapy is beneficial after the contemporary treatment of ami consisting of medical and interventional therapy. the investigators have designed a randomized, controlled study to assess the effects of short-term psychotherapy (stp) on the clinical outcomes of patients who have undergone an emergency percutaneous coronary intervention (pci) post-ami.


Eligibility criteria:
inclusion criteria: * patients admitted to san filippo neri hospital for ami and treated with primary or urgent pci. * primary ptca is performed up to 12 hours after the beginning of chest pain in cases of stemi, while patients with nstemi are enrolled if urgent ptca is being performed within 48 hours of the onset of chest pain. * only patients in whom complete revascularization is achieved are being enrolled in the study. exclusion criteria: * patients with psychiatric disorders or disability, cognitive impairment, or other life-threatening conditions are being excluded from the study.
a study of pharmacodynamics of ro5083945 in patients with head and neck squamous cell carcinoma

Conditions: Head and Neck Cancer

Summary: this open-label study will assess the pharmacodynamics, safety and efficacy of ro5083945 as compared to cetuximab in patients with head and neck squamous cell carcinoma. patients will receive at least 2 infusions of either ro5083945 or cetuximab. anticipated time on study treatment is up to 3 months, and target sample size is \<50.


Eligibility criteria:
inclusion criteria: * adult patients, \>/=18 years of age * squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx or larynx exclusion criteria: * carcinoma of nasal cavity, paranasal sinus and nasopharynx * recurrent squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx or larynx * known positivity for hiv, hepatitis b and/or hepatitis c infection
a predictive model for early metastasis in cervical cancer patients after radiotherapy

Conditions: Cervical Cancer; Radiotherapy; Distant Metastasis; Prognostic Model; Risk Factor

Summary: this study aims to help to screen out appropriate cases for consolidation therapy and more intensive follow up.

some cervical cancer patients experienced distant metastasis quickly after receiving complete radiotherapy and have a worse prognosis. however, there were few studies focused on these patients and with early distant metastasis. it is significant to predictive and screen out cervial cancer patients with a high risk of early metastasis for more comprehensive treatments and follow-up plans

Eligibility criteria:
inclusion criteria: * patients confirmed as cervical cancer by biopsies and treated with radiotherapy were initially enrolled exclusion criteria: * (1) patients treated with surgery. (2) patient received incomplete treatment somewhere else. (3) patients with cancer history. (4) patients with pelvic surgery history. (5) patients without complete pre-treatment medical information. (6) patients with unfinished radical radiotherapy. (7) patients suffered from metastasis within 3 months after radiotherapy. (8) patients without complete 1-year follow-up materials