Kornimate/medical-research-clean huggingface dataset:
feasibility and validity of remote lung function assessment

Conditions: Chronic Lung Disease

Summary: comparison of standard spirometry to non invasive remote lung function measures of chest wall movement using depth camera technology.

this study plans to test a new non invasive way of measuring lung function and compare it to the current method of blowing into a spirometer. spirometry is an essential investigation for diagnosis and assessment of severity in people with chronic obstructive pulmonary disease (copd) and other respiratory conditions, it is used in every respiratory unit and across primary care. it requires subjects to blow into a tube which measures volume and flow of expired air. it involves specialist equipment and training to perform and interpret. not all patients are capable of performing spirometry, in particular children, frail, cognitively impaired and those experiencing a flare or exacerbation of symptoms. remote lung function assessment technology has the potential to enable assessment of lung function in these groups of patients. in the future it is also hoped that it could be used to improve respiratory disease monitoring outside the healthcare environment such as in the patients home. this new method uses the latest infra-red depth detection cameras to measure chest wall movement. (n.b this does not capture identifiable images). we would like to record participants chest wall movements while blowing into the spirometer.

Eligibility criteria:
inclusion criteria: 1. patients attending outpatient department in respiratory medicine. 2. scheduled to undergo spirometry - exclusion criteria: 1. unable to give informed consent 2. unable to perform spirometry -
clinical effect of rebamipide on chronic gastritis

Conditions: Gastritis

Summary: to investigate the clinical effect of rebamipide in chronic gastritis patients. patients with chronic gastritis were randomly divided into the experimental group and the control group. the experimental group were treated with rebamipide 0.1g tid and optimization of life style, and the control group were only optimized their life style for 26 weeks. upper gastrointestinal endoscopy was performed in all patients to evaluate the severity of gastritis by modified lanza score (mls) and the histology by the updated sydney system before and after treatment.


Eligibility criteria:
inclusion criteria: * with the symptoms as follow: epigastric pain, abdominal discomfort, abdominal distention, poor appetite, nausea, vomiting and so on * diagnosed as chronic gastritis with endoscopic and pathological methods * agree to join in this clinical trail exclusion criteria: -
natural killer(nk) cell therapy for aml minimal residual disease

Conditions: Minimal Residual Disease

Summary: this is an open-label, phase i study of qn-030a (allogeneic nk cell therapy) in acute myeloid leukemia minimal residual disease(aml mrd). this clinical study is to evaluate the safety, tolerability and preliminary efficacy of qn-020a in patients with aml mrd, where a "3+3" enrollment schema will be utilized at dose escalation stage. up to 18 patients will be enrolled.


Eligibility criteria:
key inclusion criteria: * provision of signed and dated informed consent form(icf) * ≥18 years old * subject diagnosed of aml mrd. * eastern cooperative oncology group (ecog) performance status ≤1 * adequate organ function as defined in the protocol * donor specific antibody (dsa) to qn-030a: mfi ≤ 2000 key exclusion criteria: * allergic to drug used in this study * accept other anti-tumor drug within 2 weeks of day 0 (first qn-030a dose infusion) * prior allogeneic hematopoietic stem cell transplant (hsct) within 6 months of day 0, received systemic immunosuppressive therapy within 7 days of day 0, or likely to require systemic immunosuppressive therapy * acute promyelocytic leukemia (apl) * active central nervous system leukemia. * uncontrolled, active clinically significant infection * clinically significant cardiovascular disease as defined in the protocol * history of central nervous system (cns) disease such as stroke, epilepsy. * females are pregnant or lactating * known hiv infection, active hepatitis b (hbv) or hepatitis c (hcv) infection * investigator-assessed presence of any medical or social issues that are likely to interfere with study conduct or may cause increased risk to subject
the effect of neuroathletic training in cross-country skiers

Conditions: Skiing/Snowboarding

Summary: the aim of this study was to investigate the effects of neuro-athletic training on physical performance and position sense in cross-country skiers.

cross-country skiing is the least dangerous but tiring winter sport performed in snowy environments with different heights, distances, and slopes using ski equipment such as skis, shoes, and poles with various features. in this sport, both the lower and upper body require rapid power production and high maximal oxygen consumption. when technique, conditioning, and skill are combined in cross-country skiing, the resulting performance reaches the highest level. in order for an athlete to perform well, they must have the capacity to produce power continuously and quickly. cross-country skiing is often associated with the development of strength, speed, agility, balance, endurance, fatigue resistance, and oxygen capacity. physical training alone is not enough for an athlete to achieve high success. physical training must be combined with the visual system, vestibular system, and proprioceptive system. the quality of the stimuli coming from these systems in an athlete positively affects the athlete's physical performance and success in competitions. therefore, in addition to the physical training that the athlete will do, neuro-athletic training that stimulates the visual, vestibular, and proprioceptive systems will be implemented in the cross-country skiing sports branch, considering that it can increase the athlete's performance by improving muscle strength, core endurance, balance, and proprioceptive sense. the sample of the study will consist of 26 cross-country skiing athletes between the ages of 12-18 who participate in training at the arkut cross-country and biathlon center. the athletes will be randomly divided into 2 groups by coin toss method. all athletes will participate in routine training. neuroathletic training will be given to one group in addition to routine training, and its effect on the athletes' performance will be examined.

Eligibility criteria:
inclusion criteria: * have been cross-country skiing for at least 3 years and regularly participate in training * be a volunteer * complete a trail making test exclusion criteria: * have had lower extremity surgery in the last 2 years * have no neurological or orthopedic disorders

Keywords: cross-country skiing neuroathletic training strength balance proprioception
outcomes of fracture odontoid management

Conditions: Odontoid Fracture

Summary: this study aims to evaluate the long-term outcomes of treating patients with odontoid fractures admitted to the trauma unit of assiut university hospital.

study focuses on assessing the long-term results of treatment for patients diagnosed with odontoid fractures. these fractures involve the odontoid process of the second cervical vertebra and can be serious due to their potential impact on spinal stability and neurological function. the study is conducted within the trauma unit of assiut university hospital, indicating that it involves patients who have been admitted for acute care following such injuries. the long-term outcomes likely include factors such as recovery rates, complications, and the effectiveness of different treatment modalities. the study population consists of patients admitted to the trauma unit of assiut university hospital with diagnosed odontoid fractures. this population likely includes individuals of various ages and backgrounds who have experienced trauma leading to this specific type of fracture. the study may focus on patients who have undergone different treatment strategies, such as surgical intervention or conservative management, to assess the effectiveness and outcomes of these approaches over time. the demographic characteristics of the population could include age, gender, cause of injury, and pre-existing health conditions, which might influence treatment outcomes.

Eligibility criteria:
inclusion criteria: * all patients with odontoid fractures presenting to assiut university hospital - department of orthopaedic and trauma surgery who have completed a minimum of 2 year follow up regardless of age, mechanism of injury, neurological status or type of treatment applied. exclusion criteria: * • patients who are not available for two year follow-up * patients who refuse to participate in the study

Keywords: odontoid fracture management long term outcomes
raltitrexed concurrent with radiotherapy for elderly chinese patients with squamous cell carcinoma of esophagus

Conditions: Esophagus Squamous Cell Carcinoma

Summary: concurrent chemoradiotherapy is one of the curative options for esophageal squamous cell carcinoma. we evaluated the efficacy and toxicity of raltitrexed with concurrent radiotherapy in elderly patients with esophageal cancer.


Eligibility criteria:
inclusion criteria: histological or cytologic diagnosis of esophageal carcinoma. ecog performance status 0-1. age:70-85 years. joined the study voluntarily and signed informed consent form patients must not have received any prior anticancer therapy. stage iia-ⅳa(ajcc 2002). target lesions can be measured according to recist criteria. no serious system dysfunction and immuno-deficiency, adequate organ function including the following: hemoglobin ≥9 g/dl, wbc≥3x109/l, neutrophils (anc )≥1.5x109/l, platelet count ≥100x 109/l, tbil\<1.5 x uln, alt and ast ≦ 2.5 x uln, creatinine ≦ 1.5 x uln. exclusion criteria: multiple carcinomas of the esophagus. biopsy-proven invasion of the tracheobronchial tree or tracheoesophageal fistula. metastatic disease (m1b). a primary tumor that extended to within 2 cm of the gastroesophageal junction. prior chemotherapy, prior thoracic radiation, surgical resection of the primary tumor. history of a second malignancy other than nonmelanoma skin cancer.

Keywords: esophageal neoplasma adjuvant therapy raltitrexed radiotherapy
roll vs wgll for non-palpable breast lesions

Conditions: Breast Cancer

Summary: here were present a controlled clinical trial comparing wire-guided lesion localization (wgll)and radioguided occult lesion localization (roll) in patients treated for nonpalpable breast lesions at the instituto nacional de cancerología (national cancer institute)in bogotá,colombia.

the aim of this study was to compare the radioguided occult lesion localization (roll) technique with the wire-guided lesion localization (wgll) technique to assess the optimal localization and excision of nonpalpable breast lesions in patients at a unique reference medical center. a controlled clinical trial was designed to compare the wgll and roll techniques in women presenting with breast lesions diagnosed by mammography or ultrasound at the instituto nacional de cancerología in bogotá, colombia from march 2006 to june 2011. this study evaluate 129 patients; 64 (49.6%) patients were treated using roll and 65 (51.4%) using wgll.

Eligibility criteria:
inclusion criteria: * female patients older than 18 years * lesions suggesting malignancy (birads 4 and 5) * solid nodules in postmenopausal women (birads 3 mammograms). exclusion criteria: * pregnant or nursing * patients with suspected multifocal or multicentric disease (suspicious microcalcifications scattered over a wide area on mammography) * patients with retro-areola lesions (less than 2 cm away from the nipple) * lesions that had previously undergone surgery or excisional biopsies in the compromised breast

Keywords: breast cancer non palpable breast lesions radioguided occult lesion localization
running effect on cardiovascular and muscular parameters

Conditions: Males; Untrained; 30-50 Years Old; Healthy

Summary: the purpose of the study is to determine the effect of 16 weeks of running exercise on various parameters related to heart, vascular systems, blood, and muscle in untrained males 30-50 years old. further, the investigators assess which of the above mentioned parameters may explain the increase of running performance most accurate.


Eligibility criteria:
inclusion criteria: * males * untrained (\< 2 endurance exercise sessions/week) * 30-50 years old exclusion criteria: * pathological changes of the heart * inflammable diseases * medication/diseases affecting cardiovascular system and muscle * very low physical capacity (\< 100 watt at ergometry) * obesity (bmi \> 30 kg/m2) * more than 2 weeks of absence during the interventional period * more than 2 exercise session beside the intervention * contraindication related to mri-assessment (i.e. claustrophobia, magnetizable intracorporal artefacts)

Keywords: running exercise cardiac hypertrophy blood maximum oxygen uptake intervention untrained males
additional effects of mobilization with movement with upper quadrant core strengthening in rotator cuff related pain:a randomized controlled trail

Conditions: Rotator Cuff Syndrome

Summary: this study is a randomised control trial and the purpose of this study is to determine the additional effects of mobilization with movement with upper quadrant core strengthening in rotator cuff related pain .

the purpose of this study is to determine the effects of mobilization with movement with upper quadrant core strengthening in rotator cuff related shoulder pain on a. pain b. range of motion c. propioception d. kinesiophobia data collection procedure: participants of interest would be approached and explained about the research. informed written consent will be taken. recruited participants will be allocated to either of the groups through a sealed opaque envelope method.

Eligibility criteria:
inclusion criteria: * age 18-65 years * both genders * unilateral shoulder pain of traumatic origin * scoring should be less than 8 on numeric pain rating scale * symptoms lasting more than 6 weeks * pain on active shoulder movement * pain provoked by atleast three of the following tests. a. neer test b. hawkins-kennedy test c. empty can test d. full can test e. painfull arc test f. resisted external rotation test * patients reffered by a rehabilitation and orthopedic specialistwith diagnosis of rotator cuff injury, subacromial impingement syndrome, subacromial pain exclusion criteria: * history and clinical presentation compatible with complete rotator cuff or bicep brachia rupture * adhesive capsulitis * history of dislocation * glenohumeral osteoarthritis * cancer * auto-immune inflammatory conditions and infection * positive joint integrity tests ( ant. and post. drawer tests) * hill sachs lesions * bankarts lesions * cervical rib * previous shoulder or neck surgery or fracture * familiar pain provoked by neck movements * presence of radicular sign * diagnosis of fibromyalgia * clinical depression * rheumatoid arthritis * poor bone quality ( osteoporosis) * vertobrobasilar insufficiency test
psychological and social factors that may increase the risk of developing chronic pain after surgery in women with breast cancer

Conditions: Breast Cancer; Pain; Psychosocial Effects of Cancer and Its Treatment

Summary: rationale: certain psychological and social factors may increase the risk of developing chronic pain after surgery. evaluating these factors over time in patients who have undergone surgery for breast cancer may help doctors plan treatment and improve patients' quality of life. purpose: this clinical trial is studying the psychological and social factors that may increase the risk of developing chronic pain after surgery in women with breast cancer .

objectives: primary * determine the psychological and sociological factors that predispose post-mastectomy pain syndrome after surgery in women with resectable breast cancer. secondary * determine the psychological and sociological factors that predispose post-surgical pain in these patients. * evaluate emotional distress over time in these patients. * evaluate the acute and chronic pain over time in these patients. outline: this is a multicenter study. patients complete multiple questionnaires, including hospital anxiety and depression scale (had), maudsley personality inventory (mpi), pcs, and qlq-c30, to evaluate psychological variables (alexithymia, neurosis, repression of negative emotions, solicitude, dramatization, emotional distress) and quality of life. post-mastectomy chronic pain (pmcp) syndrome is measured immediately after surgery and at 24 hours, day 6, and 5 months post-surgery. a subgroup of patients (20 with pmcp and 20 without pmcp) are followed at months 5 and 6 months post-surgery for medication use, pathological problems, morbid events, family history, and environmental factors. projected accrual: a total of 150 patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * diagnosis of breast cancer * mastectomy or lumpectomy, including axillary lymph node dissection, planned * analgesic fixed (or ordered) the morning of surgery * no stage iii analgesic planned * hormone receptor status not specified patient characteristics: * female * menopausal status not specified * who performance status 0-2 * other prior malignancy allowed * no american society of anesthesiologists' class iv * no contraindication or drug addiction * no uncontrolled conditions, including any of the following: * diabetes * thyroid disease * neuropsychiatric disease * infection * insufficient coronary function * nyha class iii-iv heart disease prior concurrent therapy: * no recent major surgery * no participation in another medical or surgical clinical trial in the past 30 days * prior breast surgery for a benign lesion or malignant lesion allowed

Keywords: pain psychosocial effects of cancer and its treatment stage iiia breast cancer stage iiib breast cancer stage i breast cancer stage ii breast cancer stage iiic breast cancer
comparison of tai chi and pulmonary rehabilitation on the effect of indacaterol in treatment naïve copd participants

Conditions: Chronic Obstructive Pulmonary Disease

Summary: tai-chi may be a beneficial form of rehabilitation which is acceptable to the chinese population but no data exist concerning metabolic responses to tai-chi in copd patients. investigators conduct an randomized controlled trial to evaluate the synergistic effect of a long acting β2-agonists with tai-chi as a culturally acceptable form of pr in the asian population. classical western style pulmonary rehabilitation will serve as a comparator investigators propose a prospective randomized controlled trial in which 120 bronchodilator naïve participants (age 40-80 with gold ii-iv copd (post-bronchodilator fev1 ≥ 25% and \<80 % of the predicted normal, and a post-bronchodilator fev1/fvc \< 0.70) are randomized to receive a 26 weeks course of indacaterol with either tai-chi or conventional pulmonary rehabilitation. only participants who are residents in xingning city (guangdong province, china) will be recruited. both tai-chi and pulmonary rehabilitation will be given by qualified instructors at a rural location in southern china (xingning). a qualified uk physiotherapist will also be involved in the management of pulmonary rehabilitation program to further make sure the high quality of pulmonary rehabilitation has been applied. both arm participants will also receive in an open label fashion indacaterol 150µg qd. for 6 months giving 2 therapy groups (tai-chi/indacaterol, pulmonary rehabilitation/indacaterol). the primary endpoint of this study is change in sgrq between tai-chi/indacaterol and pulmonary rehabilitation/indacaterol at 14 weeks after entry and the secondary endpoints are change in fev1% and six minute walk distance. the planned recruitment will be 120 with a view to obtaining 100 completers. the investigators propose the study starts on 31 dec 2014 and completes on 30 june, 2016.


Eligibility criteria:
inclusion criteria: 1. bronchodilator naïve patients 2. age 40-80 with gold ii-iv copd (post-bronchodilator fev1 ≥ 25% and \<80 % of the predicted normal, and a post-bronchodilator fev1/fvc \< 0.70) 3. patients who are residents in xingning city (guangdong province, china) will be recruited. exclusion criteria: 1. patients currently or previous on any type of tai chi exercise or pulmonary rehabilitation 2. patients with a history of malignancy of any organ system treated or untreated, within the past 5 years. 3. patients with clinically significant renal, cardiovascular, neurological, metabolism, immunological, psychiatric, gastrointestinal, hepatic, or haematological abnormalities. 4. patients with concomitant pulmonary disease (e.g. asthma, lung fibrosis, primary bronchiectasis, sarcoidosis, interstitial lung disorder, tuberculosis) 5. patients with obesity (bmi\> 40 kg/m2). 6. patients requiring long term oxygen therapy (\> 12 h a day) on a daily basis for chronic hypoxemia or recovering from acute exacerbation less than 6 weeks. 7. patients with asthma.

Keywords: copd pulmonary rehabilitation
optimization of pediatric tonsillectomy to improve analgesia

Conditions: Pain, Postoperative; Tonsillar Hypertrophy; Tonsillitis; Pediatric Sleep Apnea; Sleep-Disordered Breathing

Summary: the purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery in children and adolescents.

this is a randomized, double-blind, parallel-group, dose-escalation investigation. participants ("children" defined as ages 3 - \< 12 years and "adolescents" defined as ages 12 - 17 years) will be randomized 2:1 to either methadone or short-acting opioid. surgical and anesthesia care, except for intraoperative opioid management, are not altered for study purposes. the trial will include 2 periods in 3 parallel age groups. in the first period, each age cohort will recruit 66 patients (44 methadone, 22 control). children will be randomized to methadone 0.15 mg/kg age-ideal body weight and adolescents to 0.2 mg/kg age-ideal body weight. when an age cohort reaches 66 patients, this is the end of the first period. at that time, an unblinded interim analysis will be conducted in that cohort to determine if dose escalation to 0.2 mg/kg dose in children and the 0.25 mg/kg dose in adolescents are met. methadone dose escalation will be based on clinically meaningful differences in need for rescue opioid in the pacu and the absence of well-defined opioid adverse events. outcomes data will be collected in hospital and after discharge. with daily surveys for 7 days, and 3 phone calls on day 30, 3 months and 6 months after surgery.

Eligibility criteria:
inclusion criteria: 1. age \>= 3 and \< 18 years 2. elective tonsillectomy +/- adenoidectomy 3. signed informed consent by parent or legal guardian 4. children \>= 12 years must provide signed written consent, children \>= 7 years must provide verbal assent 5. negative pregnancy test within 48 hours for post pubescent females exclusion criteria: 1. history of chronic kidney or liver disease 2. current diagnosis of a chronic pain disorder 3. planned admission to the pediatric intensive care unit (picu) 4. additional procedures under general anesthesia for which opioids would be prescribed

Keywords: methadone tonsillectomy opioid
pregabalin in partial seizures extension study

Conditions: Seizures

Summary: to evaluate long-term efficacy and safety of pregabalin (150 to 600mg/day) as adjunctive treatment in patients with partial seizures.


Eligibility criteria:
inclusion criteria: * met the inclusion/exclusion criteria for a0081005 * have completed the 21-week study and have shown a significant clinical response and wish to continue treatment exclusion criteria: * having a treatable cause of seizure. * having a progressive neurological or systemic disorder

Keywords: phase 4, open label, seizures, epilepsy, add-on therapy, pregabalin, lyrica