Kornimate/medical-research-clean huggingface dataset:
study to assess the safety and effects of autologous adipose-derived stromal cells in patients after stroke

Conditions: Stroke

Summary: the intent of this clinical study is to answer the questions: 1. is the proposed treatment safe 2. is treatment effective in improving the disease pathology of patients after stroke and clinical outcomes?

adipose-derived stromal cells (ascs) are a novel therapy for patients suffering from stroke. by injecting ascs either into the internal carotid artery, these regions may become populated with the ascs, thereby potentially restoring brain function. ascs are a patient-derived ("autologous") cell transplantation technology that is delivered to the patient into the internal carotid artery and intravenously. the therapy is composed of cells derived from a patients' own adipose tissue that are isolated within approximately 1 hour and immediately delivered back to the patient.

Eligibility criteria:
inclusion criteria: * males and females between age 18 and 80 years. * symptoms and signs of clinically definite ischemic stroke or hemorrhagic stroke * dwi-mri has reliably shown relevant ischemic lesions * extracranial duplex/transcranial doppler must confirm intra/extracranial arteries permeability * the stroke is severe (nih stroke scale \>= 8 before procedure) * up to date on all age and gender appropriate cancer screening per american cancer society. exclusion criteria: * females who are pregnant or nursing or females of childbearing potential who are unwilling to maintain contraceptive therapy for the duration of the study * life expectancy \< 6 months due to concomitant illnesses. * exposure to any investigational drug or procedure within 1 month prior to study entry or enrolled in a concurrent study that may confound results of this study. * active infectious disease and/or known to have tested positive for hiv, htlv, hbv, hcv, cmv (igm \> igg) and/or syphilis will have expert consultation to determine eligibility based on the patient's infectious status * any illness which, in the investigator's judgment, will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results * patients on chronic immunosuppressive transplant therapy * systolic blood pressure (supine) ≤90 mmhg or greater than 180mmhg * resting heart rate \> 100 bpm; * active clinical infection being treated by antibiotics within one week of enrollment. * known drug or alcohol dependence or any other factors which will interfere with the study conduct or interpretation of the results or who in the opinion of the investigator are not suitable to participate. * history of cancer (other than non-melanoma skin cancer or in-situ cervical cancer) in the last five years. * unwilling and/or not able to give written informed consent.
interventions to decrease the impact of post-operative ileus after liver transplant or resection surgery

Conditions: Ileus

Summary: this is a randomized controlled trial to assess ways to address post-operative ileus (poi) in adult patients on the liver transplant service undergoing either liver transplant or resection surgery. patient who speak and understand english will be randomized into one of three groups including a.)control group receiving standard therapy for post-operative ileus, b.)group receiving standard therapy and acupressure bracelets, and c.)group receiving standard therapy and sugar free gum four times daily.

any patient undergoing liver transplant or resection surgery will be asked to participate in the study and assigned to a control or investigational group. pertinent information will be collected from the medical record including gender, age in years, diagnosis, type of surgery, length of stay, medications used for pain or nausea, and first bowel movement. the subjects will also be asked to keep a journal of their bowel habits, signs and symptoms of gastrointestinal distress/post-operative ileus, use of medications, first bowel movement, satisfaction with bowel management and any additional comments. aims of the study are to determine the effectiveness of the three arms of this trial for the resolution of poi as noted by first post-operative bowel movement; to determine if there is a difference in the length of stay based on the interventions; and to determine if there is a difference in patient satisfaction based on the intervention.

Eligibility criteria:
inclusion criteria: * patients 19 years or older who speak and read english and have had a liver transplant or liver resection surgery exclusion criteria: * patients less than 19 years of age having liver transplant or liver resection surgery * non-english speaking * pregnancy

Keywords: liver transplant liver resection
vitamin a for bpd prevention

Conditions: The Relationship Between Oral Vitamin A Administration and the Incidence of BPD in Preterm Infants Born Before Week 29 of Pregnancy

Summary: chronic bronchopulmonary dysplasia (bpd) is a very common complication in preterm infants born at a young gestational age, and is a serious disease that impairs respiratory long-term outcome and is associated with higher-frequency neurodevelopmental injury. lowering the incidence of bpd may improve the health of the preterm babies and neurodevelopmental delay of preterm infants.vitamin a deficiency may be one of the factors associated with the development of bpd in preterm infants. according to the literature, oral vitamin a administration can lower the incidence of bpd. in our study we plan to give 5000 units of retinol / dose / day, every day for 28 days.


Eligibility criteria:
inclusion criteria: * premature babies under 29 weeks, at any birth weight * a preterm baby is less than 4 days to life exclusion criteria: * major congenital malformations * known chromosomal disorders
diabetes risk reduction through eat, walk, sleep and medication therapy management for depressed cambodians

Conditions: Diabetes; Depression

Summary: the primary aim of the study is to compare the effect of three different interventions on lifestyle risk factors and biological risk factors for type 2 diabetes in depressed cambodians. the three different interventions are lifestyle, lifestyle plus medication therapy management, and social services.

cambodian americans have high risk for major depressive disorder and for type 2 diabetes. depression is a known risk factor for diabetes. some antidepressants can also increase risk of diabetes by causing weight gain. dream will test the effect of lifestyle and medication therapy management (mtm) compared to social services (control) on diabetes risk among depressed cambodian americans. community health workers (chws) will deliver the lifestyle intervention and assist pharmacists with mtm. lifestyle and biological risk factors for diabetes, such as depressive symptoms, hba1c and insulin sensitivity, will be measured before and after the interventions.

Eligibility criteria:
inclusion criteria: * self-identified as cambodian or cambodian-american * khmer speaking * likely major depressive disorder * elevated diabetes risk score per ada guidelines * ambulatory * competent to give consent. exclusion criteria: * pregnancy or plans to become pregnant in the next 2 years * previous diagnosis of diabetes * seeing or hearing problems that would interfere with group sessions * currently being followed by a physician for major medical problem * serious thinking or memory problems (e.g., schizophrenia or dementia) * 3 or more days in a psychiatric hospital or self-harm in the past 2 years.

Keywords: diabetes depression medication therapy management community health workers cambodian refugee prevention
impact of rapeseed and sunflower oils on proteomic biomarkers of diseases.

Conditions: Cardiovascular Diseases

Summary: this study will test the impact of vegetable oils with contrasting fatty acids composition on biomarkers of health (cardiovascular, kidney diseases and diabetes) after twelve weeks supplementation. we will use sunflower oil (high in pufas), rapeseed oil (high in mufas, locally produced) and a non-intervention control. we have developed a sensitive and selective urinary proteomic biomarker of cardiovascular disease which we will use in a double-blinded randomised study.

the intervention follows a parallel double-blind randomised control design. the intervention duration is 12 weeks, with a mid-point assessment at 6 weeks. randomisation to groups; rapeseed oil, sunflower oil or habitual diet is performed using a block stratified allocation based on age (under or over 45) and bmi (under or over 30kg/m2) and is carried out remotely via phone. participants allocated to either oil groups are instructed to consume the oils uncooked, as a partial replacement to their habitual fat intake. participants in the control group are asked to not change any aspect of their diet. spot urine samples are collected from all participants at all time points for measurement of the primary outcome (proteomic biomarker score). urine is collected in a plastic tube, mid-flow, as the second urination of the day at baseline, 6 and 12 weeks. fasting venous blood is collected for the assessment of secondary outcomes, at baseline, 6 weeks and 12 weeks. participants are also asked to complete a 2-day food diary at weeks 0, 6 and 12

Eligibility criteria:
inclusion criteria: * overweight adults with a bmi\>25 and/or a large waist (male \>102cm and female \>88cm), * aged 25-75 years * no history of chronic disease of the gi tract * not taking medication (other than the contraceptive pill). exclusion criteria: * pregnant or lactating * allergy to any vegetable oils and vegetable oil-derived products

Keywords: rapeseed oil sunflower oil proteomics cardiometabolic cardiovascular fatty acids monounsaturated fatty acids seed oils dietary fat
the effect of virtual reality application on anxiety and fear levels of children planned for daily surgery

Conditions: Child; Fear; Anxiety

Summary: objective: this study was conducted to determine the effect of the animation video to be watched by child patients aged 5-10 before day surgery on their anxiety and fear levels in the preoperative period. method: this research, which was conducted as a randomized controlled experimental study, was conducted with 80 children. participants sociodemographic data, blood pressure, heart rate, child fear scale and yale modified preoperative anxiety scale child form were used to collect data. comparisons in independent pair groups with kolmogorov smirnow test whether the data received comply with normal distribution; since the assumption of normality is met, comparisons in dependent pair groups are made with the significance test (t test) of the difference between two means; since the assumption of normality was met, the significance test of the difference between two spouses was performed (two paired samples t test).

objective: this study was conducted to determine the effect of the animation video to be watched by child patients aged 5-10 before day surgery on their anxiety and fear levels in the preoperative period. method: this research, which was conducted as a randomized controlled experimental study, was conducted with 80 children. participants sociodemographic data, blood pressure, heart rate, child fear scale and yale modified preoperative anxiety scale child form were used to collect data. comparisons in independent pair groups with kolmogorov smirnow test whether the data received comply with normal distribution; since the assumption of normality is met, comparisons in dependent pair groups are made with the significance test (t test) of the difference between two means; since the assumption of normality was met, the significance test of the difference between two spouses was performed (two paired samples t test).

Eligibility criteria:
inclusion criteria: not having an audiovisual disease exclusion criteria: having an audiovisual disease

Keywords: child anxiety fear distraction
non verbal communication and dementia

Conditions: Neurocognitive Disorders; Alzheimer Disease

Summary: cognitive impairements in alzheimer's and apparented disorders may lead to the decreased engagement in activities, spetially in moderate and advanced stages of evolution. the lack of stimulation for people with dementia is associated with the risk of challenging behaviors, depressives symptoms, sleeping disorders or faster cognitive deterioration. those challenges may lead to the increased administration of pharmacological treatments, though the risks of neurleptics use in this population are currently known. in this context, non-pharacological interventions hold a significant place in dementia care. this research focuses on cognitve stimulation activities. more precisly, our study compares two aproaches using the reading groups. the first type (" usual " reading group) is based on the principle of stimulating those cognitive functions which dicreases with the evolution of dementia. the second (montessori reading group) approach relies on the idea to use preserved capacities in order to compensate the cognitive impariments. the aim of our study is to compare the impact of these two non-pharmalogical interventions on non-verbal communication. the collected datas will help analyzing and understanding the internal and behavioral states of people living with dementia. our study will also extend relfexions about cognitive stimulation groups in care institutions.


Eligibility criteria:
inclusion criteria: * 65 years and more * diagnosed with alzheimer's disease and/or related disease (frontotemporal dementia, vascular dementia, multiple etiologies dementia, lewy's body dementia) according to dsm-iv-tr criteria (2005) * mmse ≤ 15 * good reading ability assessed using montessori reading test (ability to read text written in arial 40) * the written agreement of the patient, primary caregiver or curator or or guardian to participate in the study and to make a film about the participant. * patient receiving social security benefits exclusion criteria: * previously known associated psychotic disorder * deafness not compensated by hearing aid * extrapyramidal syndrome diagnosed by a practitioner * tendency to daytime sleepiness (score 6 on the karolinska somnolence scale) * patient with disruptive behaviour disorders such as screaming and/or motor agitation likely to affect the smooth running of the workshop * subject deprived of liberty by judicial or administrative decision. * subject under exclusion for another research protocol. * presence of motor stereotypes * patient receiving state medical assistance (ame) * patient under justice safeguard * if the patient or guardian cannot be given informed information

Keywords: non pharmacological interventions cognitive stimulation non-verbal communication montessori lifestyle
open-label, dose-finding study evaluating safety and pk of fpa144 in patients with advanced solid tumors

Conditions: Advanced Solid Tumors; Gastric Cancer; Transitional Cell Carcinoma of the Bladder

Summary: this is a three-part, open-label, safety, tolerability, and pk study of fpa144. patients will be enrolled in part 1 (a or b, dose escalation) or part 2 (dose expansion) of the study, but not both.

part 1a is a dose-escalation study in patients with any locally advanced or metastatic solid tumor or lymphoma for which standard therapies have been exhausted. part 1b will further assess safety and evaluate pk of fpa144 in gastric cancer patients. part 2 patients will be enrolled and treated in order to further characterize safety and preliminary efficacy in a selected cancer patient population with the greatest potential for clinical benefit from fpa144 treatment.

Eligibility criteria:
inclusion criteria: * life expectancy of at least 3 months * ecog performance status of 0 to 1 • in sexually-active patients, willingness to use 2 effective methods of contraception * adequate hematological and organ function, confirmed by lab values * tumor tissue must be available for prospective determination of fgfr2b overexpression * locally recurrent or metastatic disease that has progressed on or following standard treatment, or is not a candidate for standard treatment * histologically or cytologically confirmed transitional cell carcinoma of the genitourinary tract * measurable disease as defined by recist version 1.1 exclusion criteria: * untreated or symptomatic central nervous system (cns) metastases * impaired cardiac function or clinically significant cardiac disease - treatment with any anticancer therapy or participation in another therapeutic clinical study with investigational drugs \</=14 days (\</=28 days for patients in korea) prior to first dose of fpa144 * ongoing acute adverse effects from prior anticancer or investigational therapy \> nci ctcae grade 1 * retinal disease or a history of retinal disease or detachment * corneal defects, corneal ulcerations, keratitis, keratoconus, history of corneal transplant, or other known abnormalities of the cornea * major surgical procedures are not allowed ≤28 days prior to fpa144 administration * females who are pregnant or breastfeeding; women of childbearing potential must not be considering getting pregnant during the study - presence of any serious or unstable concomitant systemic disorder incompatible with the clinical study * known allergy or hypersensitivity to components of the fpa144 formulation including polysorbate * history of prior malignancy except: * a) curatively treated non-melanoma skin cancer or * b) solid tumor treated curatively more than 5 years previously without evidence of recurrence or * c) history of other malignancy that in the investigator's opinion would not affect the determination of study treatment effect * prior treatment with any selective inhibitor (e.g., azd4547, bgj398, jnj-42756493, bay1179470) of the fgf-fgfr pathway

Keywords: fgfr2b, fgfr2, fgfr, bladder neoplasms, esophageal cancer
omega 6:omega 3 ratio and progression of age-related macular degeneration (amd).

Conditions: Age-related Macular Degeneration

Summary: docosahexaenoic acid (dha) supplementation has been shown to prevent specific age-related changes in the retina through biochemical and functional evaluations, but it is unclear whether increased dha intake-reflected through elevated dha+epa blood levels-can affect the natural history and progression of age-related macular degeneration (amd). amd is a disease affecting the macula, the part of the eye containing cone photoreceptors at the center of the visual field. the macula is responsible for vision in most daily functions, including reading, seeing fine details, and colour recognition. severe amd can lead to a central scotoma, severely impairing daily functioning. amd can be divided into two forms: the more severe wet amd, consisting of proliferation of new blood vessels in the retina, and dry amd characterized by the development of drusen, a buildup of extracellular material . the investigators are focused on the group with the highest risk of developing the two advanced forms of amd \[wet amd or central geographic atrophy\]: patients with unilateral wet amd and dry amd in their other eye. the study will consist of following up a cohort of such subjects and monitoring their visual function in a comprehensive manner. working in concert with clinical ophthalmologists and basic scientists, the investigators will monitor "dha+epa" and "omega6:omega3 fatty acid ratio" levels in the blood, inherited predispositions through genetic analysis, lipofuscin (an accumulated waste product) levels \& amd progression via fundus photography, visual acuity, and retinal function via full-field and multifocal electroretinograms. these different factors will be cross-correlated and evaluated to determine how omega-3 fatty acids affect the progression of amd.


Eligibility criteria:
inclusion criteria: * 50+ years of age * nvamd (wet) in one eye, early or intermediate dry-amd in the fellow eye * taking areds vitamins (or equivalent) exclusion criteria: * central geographic atrophy * diabetic retinopathy * ocular surgery in the eye with dry-amd (not including cataract iol surgery) * underlying ocular pathology in the eye with dry-amd (especially glaucoma, dense cataracts, and retinitis pigmentosa)

Keywords: dha epa amd drusen omega-3 fatty acids omega6:omega3 ratio
effects of plyometrics versus conventional exercises on speed, strength, and injury prevention in bowlers.

Conditions: Sports Injury; Sports Physical Therapy

Summary: to compare the effects of upper body plyometric versus conventional exercises on speed, strength, and injury prevention in bowlers

bowling action is a highly skilled activity acquired over the year. a bowler needs speed and strength to challenge the batsman but the conventional protocols they follow for the speed and strength are not specific to their bowling actions. bowling can result in different types of upper extremity injuries, such as rotator cuff sprains, impingement and stress fractures. there are many injury prevention programs such as electrostimulation training, resistance training, and plyometric training that can be used to treat upper limb injuries and improve maximal strength. plyometric training can be done by overhead athletes to improve the effectiveness of throwing activity and to strengthen the rotator cuff muscles to prevent shoulder injury from overhead throwing activity. this study aims to evaluate the effectiveness of upper limb plyometric exercises on speed, strength and injury prevention in comparison with conventional exercises.

Eligibility criteria:
inclusion criteria: * players bowling for at least one year * bowlers age 18 to 35 years exclusion criteria: * any acute or chronic musculoskeletal injuries * any surgery in 6 months