Kornimate/medical-research-clean huggingface dataset:
tissue vascular optics and impedance measurements for the detection of early tissue damage and pressure ulceration

Conditions: Pressure Ulcer

Summary: pressure ulcers are common, distressing and expensive. currently scoring systems and checks by nursing staff are carried out to assess a patient's risk of developing a pressure ulcer. the investigators would like to see whether non-invasive measurements can be taken from patients to predict who might be at risk of pressure ulcers to allow us to intervene and reduce the risk of it happening.

pressure ulcers are common, distressing and expensive. currently scoring systems and checks by nursing staff are carried out to assess a patient's risk of developing a pressure ulcer. the aim is to investigate whether non-invasive physiological measurements can be taken from patients to predict who might be at risk of pressure ulcers to allow us to intervene and reduce the risk.

Eligibility criteria:
inclusion criteria: healthy volunteers: * able to give consent * male or female * over the age of 18 years * no known peripheral vascular disease * no known tissue damage * able to read and understand basic english language patients: * able to give consent * male or female * over the age of 18 years * either at risk (braden scale \<17) or confirmed category 1 or 2 pu or confirmed dti * well enough to attend lab without any attachments (iv fluids, iv medications, oxygen) * able to transfer to bed with assistance of one * able to read and understand basic english language exclusion criteria: healthy volunteers: * presence of tissue damage or ulceration in the foot * known peripheral vascular disease * known hypersensitivity to fixation tape * presence of a pacemaker * participants unable to or refusing to give informed consent patients: * known hypersensitivity to fixation tape * participants unable to or refusing to give informed consent * unable to transfer to bed with assistance of one. * requiring more than routine observations and requiring attachments (iv fluids, iv medications, oxygen) * presence of a pacemaker
global effects of a probiotic strain on lactating women

Conditions: Mastitis

Summary: in this study, the investigators will try to confirm if application of probiotic strains isolated from breast milk actually have a beneficial effect on women suffering lactational mastitis. this project has been design to offer an integrated vision of the effects of probiotherapy (lactobacillus salivarius ps2) on the human host. therefore, the investigators propose a multidisciplinary approach involving the application of microbiological, immunological, genomic, metagenomic, transcriptomic and metabolomic techniques. the hypothesis is that probiotherapy will cause different effects on the host, and the objective is the finding of markers that may support the beneficial effect of the strain in such condition.


Eligibility criteria:
inclusion criteria: * normal term pregnancy * lactating women * healthy breastfed infant women with mastitis: * clinical symptoms of mastitis * painful breastfeeding * count of staphylococci, streptococci and/or corynebacteria in milk higher than 3,000 colony-forming units/ml * leukocyte count in milk higher 6 log10/ml women without mastitis: * no clinical symptoms of mastitis * no painful breastfeeding * count of staphylococci, streptococci and/or corynebacteria in milk lower than 500 colony-forming units/ml * leukocyte count in milk lower 5 log10/ml exclusion criteria: * allergy to cow's milk protein * intolerance to lactose * antibiotic treatment * breast abscess * raynaud syndrome * any parallel disease
chinese medicine(hu yang yang kun formula) for primary ovarian insufficiency

Conditions: Primary Ovarian Insufficiency

Summary: the purpose of this research is providing valuable traditional chinese medicine theory and formula in treating primary ovarian insufficiency.

primary ovarian insufficiency is a problem that is to be solved urgently in the field of reproductive endocrine. according to the basic theory of traditional chinese medicine and clinical experience, investigators developed a chinese medicine formula(hu yang yang kun,hyyk). this research is designed according to the principle of randomized double blind control and evaluated the effectiveness and safety of hyyk, hope to provide a kind of effective medicine in treating primary ovarian insufficiency.

Eligibility criteria:
inclusion criteria: 1. aged 18-40 2. menstrual cycle change more than 7 days at least 2 times,amenorrhea less than 6 months. 3. sex hormone:bfsh\>10u/l;or e2\>80pg/ml. 4. amh\<1ng/ml. 5. informed consent and truthfully answer the question. exclusion criteria: 1. dose not meet the inclusion criteria. 2. genital tract malformation,congenital germinal aplasia, uterine amenorrhea and so on organic disease. 3. endocrine diseases such polycystic ovary syndrome、hyperprolactinemia 、dysfunctional uterine bleeding、low gonadotropin menstrual disorders and hyperthyreosis 4. autoimmune disease patients:hashimoto's thyroiditis,sle,primary chronic adrenal cortical insufficiency,asthenic bulbar paralysis,arthritis deformans,idiopathic thrombocytopenic purpura, type i diabetes and so on. 5. someone who have the following gynecological operation history: oophorocystectomy,ovarian drilling,wedgeshaped oophorectomy,adnexectomy,tubal resection,ligation of oviduct,pelvic abscess surgery,uterine arterial embolization. 6. someone who have used reproductive toxicity drugs: tripterygium wilfordii,tripterygium hypoglaucum hutch,chemotherapeutics and so on. 7. a family history of ovarian failure. 8. have receive hormone therapy in recent 3 months. 9. pregnant or lactating women. 10. with serious heart,liver and kidney disease 11. with severe psychiatric disorders . 12. have participated in other clinical trials in 3 months.

Keywords: primary ovarian insufficiency tcm intervention
to explore the influence of appetite reduction and medication effect of methylphenidate in patients with attention-deficit/hyperactivity disorder(adhd) through pharmacogenetics.

Conditions: Methylphenidate Adverse Reaction

Summary: we plan to recruit 200 children and adolescents aged between 6 to 17 years old in two years. those patients would receive clinical interview by child psychiatrists to diagnose as adhd and to exclude mental retardation, major psychiatric disorders and medical disorders. moreover, we excluded children who ever received adhd medication treatment more than one year, or received medication in recent 30 days. initial assessment includes collecting saliva sample, and complete questionnaires (snap-iv), clinical rating (cgi-s) and psychological test (cpt-ii, wisc-iv, cantab). after 1 month methylphenidate treatment, we would evaluate snap-iv, cgi-s, cgi-i and barkley psychostimulants side effects rating scale. we also would collect saliva samples to perform appetite related gene phenotyping to see the association between medication side effect and polymorphism of appetite related genes.


Eligibility criteria:
inclusion criteria: * age range from 6 years old to17 years old * diagnosis of adhd. exclusion criteria: * mental retardation. * major psychiatric disorders * major medical disorders.
naval medical center san diego (nmcsd) - ambulatory continuous peripheral nerve blocks for treatment of post-amputation phantom limb and stump pain

Conditions: Amputation; Phantom Limb; Stump Pain

Summary: the purpose of this research study is to determine if putting local anesthetic-or numbing medication-through one or two tiny tube(s) placed next to the nerves that go to an amputated limb will decrease phantom limb and/or stump pain.

specific aim 1: to determine if, compared with current standard-of-care treatment, the addition of an ambulatory continuous peripheral nerve block decreases post-amputation phantom limb and stump pain. hypothesis 1: following upper or lower extremity amputation, phantom limb and/or stump pain will be significantly decreased four weeks following a multiple-day ambulatory continuous peripheral nerve block as compared with patients receiving standard-of-care treatment (as measured on the 11-point numeric rating scale). specific aim 2: to investigate the possible relationship between the addition of a multiple-day ambulatory continuous peripheral nerve block to standard-of-care treatment of post-amputation phantom limb and/or stump pain and cortical reorganization. hypothesis 2: following upper or lower extremity amputation with subsequent phantom limb pain/sensation and/or stump pain, the addition of a multiple-day ambulatory continuous peripheral nerve block to standard-of-care treatment will result in cortical reorganization during and four-weeks following the perineural infusion (as measured by mri).

Eligibility criteria:
inclusion criteria: * previous upper or lower limb amputation including at least one metacarpal or metatarsal bone, respectively * age 18 years or older * phantom limb and/or stump pain described as at least a 2 on the nrs for the previous week \[and pain occurring on a weekly basis over the previous month\] * willing to have an ambulatory perineural infusion for 6 days * willing to avoid additional "new" analgesic interventions from 4 weeks prior to at least 4 weeks following catheter placement, and preferably to 6 months following catheter placement * the availability of a "caretaker" who will transport the subject home following the procedure and remain with the subject for the first night of the infusion exclusion criteria: * known hepatic or renal insufficiency * allergy to the study medications * possessing a contraindication to perineural catheter placement or perineural local anesthetic infusion

Keywords: pain phantom limb stump pain catheter nerve block peripheral nerve block nmcsd post-amputation phantom limb or stump pain
evaluation of the efficacy and safety of nifekalant hydrochloride (nif) injection.

Conditions: Ventricular Tachycardia; Ventricular Fibrillation

Summary: efficacy and safety evaluation of amiodarone and nifekalant hydrochloride(nif) for the treatment of ventricular tachycardia and ventricular fibrillation.

after patients are hospitalized, they will be treated as usual in addition to antiarrhythmic drugs. dc will be performed again according to normal procedures for patients who were ineffective. arrhythmia drugs can only be used with nifekalant or amiodarone at random.

Eligibility criteria:
inclusion criteria: * patients with persistent ventricular tachycardia or ventricular fibrillation who have a combined physical heart disease, or who have a conventional drug ineffective or persistent idiopathic ventricular tachycardia with amiodarone indications; * age ≥ 18 years old, gender is not limited. exclusion criteria: * patients with prolonged ventricular tachycardia with qt interval and patients with qtc interval of more than 500 ms before administration; * patients with torsades de pointes (tdp); * patients with brugada syndrome; * patients with severe atrioventricular block and without pacing protection; * patients with hypertrophic cardiomyopathy (hcm) with ventricular septal thickness or (and) left ventricular wall ≥ 15 mm; * pregnant or lactating women; * patients who are not suitable for the study, considered by investigators.
non-invasive auricular simulation for exam anxiety and depression in university students

Conditions: Anxiety; Stress; Insomnia

Summary: in spain, depression, anxiety, and stress are highly prevalent in the general population as well as in college students. in college students, ramón arbués et al. found a moderate prevalence of depression (18.4%), anxiety (23.6%) and stress (34.5%). it is essential to take responsibility for promoting health education, disease prevention, protection and care for young people. academic performance can be altered due to the stressful nature of exam situations, which can lead to increased anxiety and decrease expected performance, mainly due to effects such as decreased attention span, concentration and retention of information. modulation of vagal tone is a therapeutical strategy to heightened parasympathetic activity and withdrawal sympathetic activity. auricular transcutaneous vns (atvns) by which parasympathetic nerve system is modulated by means of the stimulation of the auricular branch of the vagus nerve that provides somatosensory innervation to the external ear. it has been shown that there are different effective interventions to reduce the symptoms of stress, depression, anxiety and insomnia in university students, but they are based on psychological interventions or face-to-face and cognitive-behavioral therapeutic approach, so this study proposal incorporates noninvasive atrial stimulation as an alternative to traditional treatments, which apart from being cost-effective, is easy to apply, well tolerated and presumably can have beneficial effects in the short term. in the present pilot study, authors propose to investigate the degree of depression, anxiety and stress on crucial dates of final exams of 1st year students of the double degree physiotherapy - physical activity and sport sciences of the health department of the tecnocampus. investigators will also evaluate the feasibility of a study to assess the efficacy of a non-pharmacological intervention, through a neuroreflex stimulation of vagal tone, with a non-invasive atrial stimulation protocol.

personal pronouns have been removed

Eligibility criteria:
inclusion criteria: * at least 18 years old * tecnocampus undergraduate students from physical therapy and sports science double degree of 1rst course. * to sign the informed consent * understand catalan or spanish language * with the intention to attend to the first call exams of the 2nd trimester. exclusion criteria: * receiving pharmacological medication for anxiety or mental disorders * receiving psychological treatment * pregnancy or breastfeeding * participants with part-time enrolment * with skin lesions in both auricula, * participating in another study
evaluation of volume and electrolyte balance in hyponatremia treatment - a prospective observational trial

Conditions: Non-hypervolemic Hyponatremia

Summary: to assess quantitatively the evolution over time of electrolyte-free water clearance and electrolyte mass balance in patients with non-hypervolemic hypotonic hyponatremia

achieving recommended treatment targets in management of hyponatremia is challenging: plasma sodium must be increased effectively but, at the same time, overcorrection has to be prevented. yet, predictors of change of sodium over time have not been delineated properly. it was found, that evidence hinting to the fact that sodium baseline itself is crucial with respect to sodium evolution. the goal of this study is to gather prospective data in order to precisely delineate the role of initial sodium levels by correlating those to plasma sodium evolution and electrolyte free water evolution. it is aimed to decipher patterns of sodium evolution with respect to anthropometric data, such as body composition analyses and blood pressure and markers of innate regulation mechanisms of body volume like aldosterone and renin. in addition, apart from these clinical aspects, a better appreciation of the physiological responses to hyponatremia treatment in terms of water and electrolyte balances is undoubtedly necessary to improve understanding of the body's mechanisms involved in osmotic homeostasis and cell volume control. since studies to date also lack consideration of the intracellular department, the aim is to close that gap.

Eligibility criteria:
inclusion criteria: * adult patients ≥ 18 years * hypotonic hyponatremia * glucose-corrected plasma sodium \<130 mmol/l * serum osmolality \<280 mosmol/kg or lack of signs of non-hypotonic hyponatremia exclusion criteria: * signs of extracellular volume expansion * patients with liver cirrhosis and severe liver damage ast/alt\>3xuln, ap\>6xuln, bilirubin ≥ 3mg/dl * patients with heart failure * patients on dialysis and/or patients with oliguric renal impairment and plasma creatinine ≥ 3mg/dl * patients after organ transplantation

Keywords: electrolyte-free water clearance hyponatremia
development and clinical application of invalid foods using mealworms

Conditions: Pancreatobiliary Disease; Liver Disease

Summary: malnutrition in cancer patients continues after surgery and worsens the patient's overall health and quality of life. previous studies reported edible insects in patients' diets increased postoperative muscle mass and weight gain. therefore, by using nutritionally excellent mealworms for a long time, it is proved that nutritional status and survival rate are improved, leading to development of various products of edible insects.


Eligibility criteria:
inclusion criteria: * patients scheduled for surgery with pancreaticobiliary disease and liver cancer (metastatic liver cancer) * karnofsky performance status ≥ 70 * patients who can communicate without difficulty in obtaining a consent form for the test exclusion criteria: patients with any of the following criteria are excluded. * patients who underwent palliative surgery * patients with uncontrolled pre-operative disease * previous history of surgery affecting nutritional status * pregnant and lactating women * patients with allergy to mealworms
hvni ambulation feasibility study

Conditions: Respiratory Insufficiency; Dyspnea

Summary: the pilot/feasibility study evaluates the ability of high velocity nasal insufflation (hvni) therapy to facilitate ambulation and mobilization in patients experiencing shortness of breath, as compared to simple oxygen therapy.

the hypothesis is that hvni therapy, when implemented in conjunction to ambulatory practices, will be more effective than tau to improve patient mobility by reducing the patient's perceived dyspnea and exertion via maintaining oxygenation (reduced desaturation) and supporting ventilation (reduced work of breathing \[wob\]). the primary endpoint is exercise performance, defined as the distance and duration of patient ambulation. to provide a sample data set, the investigators will enroll up to 32 subjects to complete this feasibility assessment, with a calculated sample size of n=26 plus a 20% failure rate. this will provide sufficient initial data to inform the appropriate sample size of a follow-on randomized study. this will be a feasibility study, performed as a prospective, crossover controlled trial to evaluate the potential patient improvement during ambulation while on hvni relative to tau. patients who fit the criteria for inclusion will perform ambulation for each study arm: the control arm (tau) followed by the test arm (hvni). control group will receive the site tau (not hvni), and the test group will receive hvni therapy. in both cases the clinical management will otherwise remain unchanged based on the site soc practices. the patient fio2 and flow values will be recorded while on any supplemental oxygen. subjects will wear appropriate gear and, when applicable, have mobile carts to provide supplemental oxygen therapy (e.g. hvni vtu) during ambulation. if they meet criteria for intubation or are deemed to need intubation by the critical care team, they will undergo prompt intubation and be managed according to standard practice. after each of the study arms, the clinicians will complete perception score assessments.

Eligibility criteria:
inclusion criteria: * adults over the age of 18 years * demonstrated respiratory distress upon mild to moderate exertion (e.g. dyspnea upon standing, walking, etc.) * candidate for clinical ambulation/mobilization exclusion criteria: * hypoxemia at resting baseline: unable to maintain spo2≥88% with supplemental oxygen * inability to provide informed consent * pregnancy * known contraindication to perform ambulation, per site soc practices * inadequate respiratory drive or any known contraindications to hvni * inability to use nasal cannula and hvni therapy * agitation or uncooperativeness * determined by the attending clinician to be sufficiently unstable or unsuitable for this feasibility study
heterozygous individuals for agxt and kidney stones

Conditions: Kidney Stone

Summary: this study seeks to examine the effects of a heterozygous mutation of the agxt gene in a stone forming population on endogenous oxalate production. participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies. subjects will then be administered an intravenous (iv) load of glycolate, providing additional blood and urine samples afterwards to measure any increase in oxalate levels.


Eligibility criteria:
inclusion criteria: * at least 18 years of age * history of calcium oxalate stones * heterozygous mutation of the agxt gene, as evidenced by results from the invitae nephrolithiasis panel * willingness to comply with a controlled diet for five days exclusion criteria: * pregnant individuals * individuals who are currently breast feeding

Keywords: kidney stone oxalate
relationship between obstructive sleep apnea and coronary atherosclerosis

Conditions: Coronary Artery Disease; Obstructive Sleep Apnea

Summary: obstructive sleep apnea (osa) is a respiratory disorder of sleep characterized by recurrent episodes of complete or partial upper airway obstruction, leading to intermittent oxygen deprivation. this results in sympathetic activation and surges in blood pressure, production of vasoactive substances, as well as activation of the inflammatory and procoagulant pathways. epidemiological evidence indicates the prevalence of osa is higher in patients with coronary artery disease than in the general population. the investigators recently showed that 65.7% and 41.9% of the singapore patients admitted with myocardial infarction were found to have previously undiagnosed osa and severe osa, respectively. in a 10-year follow-up epidemiological study, osa was independently associated with a higher prevalence of fatal and non-fatal cardiovascular events among the otherwise healthy general population. the investigators further showed that in patients who have undergone primary percutaneous coronary intervention for acute myocardial infarction, osa was an independent predictor of future adverse event rates. despite the observed association between osa and adverse cardiovascular outcomes, the underlying pathophysiological mechanisms remain unclear. in this proposal, the investigators aim to elucidate the relationship between osa and composition of coronary atherosclerotic plaques.


Eligibility criteria:
inclusion criteria: * angiogrqaphically documented coronary artery disease * de novo lesion * native coronary artery exclusion criteria: * known osa * intubation and mechanical ventilation * electrical instability with a high risk of malignant ventricular arrhythmia * cardiogenic shock * previous coronary artery bypass surgery * chronic renal failure on dialysis * inability to give informed consent

Keywords: thin-cap fibroatheroma vulnerable plaque coronary artery disease obstructive sleep apnea intravascular ultrasound