Kornimate/medical-research-clean huggingface dataset:
mri for the early evaluation of acute intracerebral hemorrhage

Conditions: Cerebral Hemorrhage; Intracranial Arteriovenous Malformations; Intracranial Hemorrhage, Hypertensive; Brain Neoplasms

Summary: what happens in the borderzone of a cerebral hemorrhage remains widely onknown and furhter the best timing for doing mr to look for vascular pathology in cerebral hemorrhage has not yet been determined. in this study we do acute mrs, a non-invasive imaging mathod to detemine the biochemsty in the border zone and structural mri for vascular malformation. we repeat structural mri after 8 weeks.

in this study we want to investigate the ability of mri to identify underlying pathology (tumor or vascular malformations) in acute patients admitted with intracerebral hemorrhage (ich). today mri-scan is normally done 3-4 weeks after symptom onset but very little is known about the early use of mri to detect underlying pathology. this would allow an early intervension and less uncertainty for the patients. we further want to investigate the metabolic penumbra-zone surrounding the hematoma. it is the current perception in the litterature that this zone represent a metabolic zone marked by apoptosis and inflammation rather than ischemia. we are planning to: when patients arrive in our stroke department they will within 7 hours be subject to mri scan with the protocoled sequences. standard sequences: axial t2, axial dwi, sagittal t1, t2 flair og axial gre-sequence. susceptibility weighted imaging (swi) chemical shift imaging (csi) multivoxel spectroscopi post contrast 3d box reconstruction after 8 weeks the patients are subject to another mri-scan in accordance with the standard clinical guideline to rule out underlying pathology. after 3 month the patients are seen in the outpatient-clinic to follow-up evaluation. to sum up the purpose of this present study is to conduct a pilot investigation of mri in the early evaluation of ich-patients. second it is our intension to use multivoxel magnetic resonance spectroscopy to study the metabolic penumbra-zone surrounding the ich.

Eligibility criteria:
inclusion criteria: * ct demonstrated ich * cardiopulmonary stable * informed consent from patient or proxy * no general contraindication of mri * age above 18 exclusion criteria: * lack of informed consent * lack of cooperability
structured physical exercise in short-term inpatient treatment of substance use disorder

Conditions: Substance-Related Disorders; Drug Abuse; Drug Dependence

Summary: in 2017, structured physical exercise with high intensity was implemented as a part of the treatment program at st. olav hospital clinic of substance use and addiction medicine. the objective of this study is to examine whether implementing structured physical exercise in the treatment program has implications for patients' physical and mental health and quality of life after completing a 3 month residential treatment program. the results of this study will benefit substance use disorder patients in the future, and may have an impact on further implementation of physical exercise in addiction treatment clinics both nationally and internationally.


Eligibility criteria:
inclusion criteria: * being an inpatient at the clinic exclusion criteria: -

Keywords: exercise therapy exercise physiology
personalized feedback intervention for latinx drinkers with anxiety

Conditions: Alcohol Abuse; Anxiety

Summary: the purpose of this study is to develop, evaluate the acceptability/feasibility (phase ia), and test (phase ib) the effectiveness of a brief, integrated, single-session, computer-based, culturally adapted personalized feedback intervention (pfi) designed to enhance knowledge regarding adverse anxiety-alcohol interrelations, increase motivation and intention to reduce hazardous drinking, and reduce positive attitudes and intention regarding anxiety-related alcohol use among latinx hazardous drinkers with anxiety.

in the first phase, the investigators will collect qualitative and quantitative feedback from focus groups to refine intervention content and evaluate treatment acceptability and feasibility of a novel, brief, integrated, culturally adapted computer-based personalized feedback intervention (pfi). in the second phase, latinx hazardous drinkers with clinical anxiety will be recruited and randomly assigned to either the refined culturally adapted anxiety-alcohol pfi (aa-pfi 2.0) or a control pfi (c-pfi). initial screening will be conducted via telephone; baseline and post-treatment data will be collected in-person; and 1-, 3-, and 6-month follow-up data will be collected online remotely.

Eligibility criteria:
inclusion criteria: * being between the age of 21 to 75 years of age * being self-identified as latinx or hispanic * fluent in spanish * meeting criteria for current hazardous drinking pattern * meeting criteria for clinical anxiety * being able to provide written, informed consent exclusion criteria: * being involved in alcohol or other substance use program * currently pregnant * current engagement in psychotherapy for anxiety

Keywords: latinx hispanic personalized feedback intervention
prone versus left-sided colonoscopy in obese patients

Conditions: Obese

Summary: for obese patients, a randomized trial aimed at determining whether colonoscopy performance and patient comfort is improved if a patient is in the prone position (lay on their abdomen) versus the traditional left-sided position.


Eligibility criteria:
inclusion criteria: * bmi \>30kg/m2 * elective colonoscopy exclusion criteria: * patients with prior colonic resection, strictures, or known colonic or intra-abdominal malignancy. * patients who are scheduled to have monitored or general anesthesia for their procedure. * emergency colonoscopy * inadequate preparation of the colon as assessed during colonoscopy

Keywords: patients presenting elective colonoscopy.
to investigate the real-world efficacy and safety of sacituzumab govitecan for her2 negative metastatic breast cancer patients in china.

Conditions: Breast Cancer Metastatic

Summary: to investigate the real-world efficacy and safety of sacituzumab govitecan for her2 negative metastatic breast cancer patients in china.

this study will conduct a multicenter, open, prospective clinical trial to investigate the real-world efficacy and safety of sacituzumab govitecan for her2 negative metastatic breast cancer patients in china.

Eligibility criteria:
inclusion criteria: local recurrent or metastatic breast cancer suitable for chemotherapy, confirmed histologically. her2-negative breast cancer(according to 2018 asco/cap her2 test guideline). 18-75 years old. ecog ps 0～2. life expectancy is not less than 12 weeks. at least one measurable lesion according to recist 1.1. received at least two cycles of sg. signed informed exclusion criteria: patients who did not receive sacituzumab govitecan treatment for two or more cycles other malignant tumors, excluding cured cervical carcinoma in situ, skin basal cell carcinoma or skin squamous cell carcinoma, have been diagnosed in the past five years. female patients during pregnancy and lactation, fertile women with positive baseline pregnancy tests or women of childbearing age who are unwilling to take effective contraceptive measures throughout the trial history of neurological or psychiatric disorders researchers believe that patients are not suitable for any other situation in this study.

Keywords: breast cancer sacituzumab govitecan
stem cell transplantation in-patient with neurological sequelae due to encephalitis or meningitis

Conditions: Encephalitis; Meningitis

Summary: to evaluate the safety and efficacy of autologous bone marrow-derived mononuclear cell transplantation in-patient with neurological sequelae due to encephalitis or meningitis

the purpose of this study is to evaluate the safety and effectiveness of autologous bone marrow-derived mononuclear cell in 22 patients with neurological sequelae due to encephalitis or meningitis at vinmec international hospital, hanoi, vietnam

Eligibility criteria:
inclusion criteria: * neurological sequelae due to encephalitis or meningitis exclusion criteria: * coagulation disorders * allergy to anesthetic agents * severe health conditions such as cancer, failure of heart, lung, liver or kidney * active infections

Keywords: encephalitis meningitis neurological sequelae due
effectiveness of intercostal tube drainage vs pigtail catheter drainage vs ultrasound-guided aspiration in management of massive malignant pleural effusion

Conditions: Malignant Pleural Effusion

Summary: pleural effusion is common in different diseases and especially malignant effusions can have fast onset symptoms such as chest pain, dyspnoea, and coughing. malignant pleural effusion (mpe) is an exudative effusion with malignant cells. it is a common symptom and accompanying presentation of metastatic disease. it impacts up to 15% of all patients with cancer and is the most common in breast, lung, cancer, lymphoma, and gynaecological malignancies . there are 150,000 new cases of mpe in the united states yearly and 100,000 in europe . patients have an overall survival (os) rate of 3-12 months after the initial diagnosis . malignant pleural effusion (mpe) poses significant challenges in management, impacting patient quality of life and overall prognosis. almost all radiological procedures can help diagnose pleural effusions . thoracentesis is used as a diagnostic and therapeutic tool. the procedure has been modified with the addition of ultrasound, that is very functional for targeting certain anatomical areas of the pleura and finding an appropriate entry point . three primary strategies are commonly employed: intercostal tube drainage, big tail catheter drainage, and ultrasound-guided aspiration. this study aims to evaluate these methods' efficacy, safety, and outcomes. to compare intercostal tube drainage, big tail catheter drainage, and ultrasound-guided aspiration in managing massive malignant pleural effusion (mpe).


Eligibility criteria:
inclusion criteria: * adult patient aged 18 years old and above. * patients diagnosed with massive malignant pleural effusion (mpe) requiring intervention. exclusion criteria: * pediatric patients aged below 18 years * patients with non-malignant causes of pleural effusion.
is nmes treatment in sepsis/ septic shock patients protective in development of icu-aw?

Conditions: Intensive Care Unit Acquired Weakness; Sepsis, Severe

Summary: background: sarcopenia (muscle weakness) characterized by a decrease in muscle mass, strength and performance is a condition that increases with old age. sarcopenia can be seen in 5-13% of patients hospitalized in icu where various treatment methods are used to prevent this weakness, the rate increases in patients with sepsis/ septic shock. muscle treatment methods are used to prevent sarcopenia in similar patients hospitalized in icu. it is predicted that "neuromuscular electrical stimulator-nmes" treatment may increase muscle mass and strength in patients who's can not be exercised actively. in this study, the contribution of nmes treatment to prevent the development of muscle weakness in patients with a diagnosis of sepsis/ septic shock followed in intensive care units (icu) was evaluated.

background: sarcopenia (muscle weakness) characterized by a decrease in muscle mass, strength and performance is a condition that increases with old age. sarcopenia can be seen in 5-13% of patients hospitalized in icu where various treatment methods are used to prevent this weakness, the rate increases in patients with sepsis/ septic shock. muscle treatment methods are used to prevent sarcopenia in similar patients hospitalized in icu. it is predicted that "neuromuscular electrical stimulator-nmes" treatment may increase muscle mass and strength in patients who's can not be exercised actively. in this study, the contribution of nmes treatment to prevent the development of muscle weakness in patients with a diagnosis of sepsis/ septic shock followed in intensive care units (icu) was evaluated. patients and methods: in our single-center, prospective clinical study, 80 patients with a diagnosis of sepsis/ septic shock who were hospitalized in icu were included. the effects of nmes and muscle strengthening and standard physiotherapy exercises on the development of icu-aw were observed. the day when our patients were diagnosed with sepsis was recorded as the first day of the study. anthropometric and ultrasonographic measurements of bilateral biceps brachii and bilateral rectus femoris muscles were recorded on the following days i.e. 3, 7, 14, 21, and 28. sarcopenia was defined by anthropometric and ultrasonographic measurement, and all patient outcome data were recorded.

Eligibility criteria:
inclusion criteria: * being in the intensive care unit * over the age of 18 * diagnosed with sepsis/ septic shock exclusion criteria: * under the age of 18 * pregnancy * having a cardiac pacemaker * amputated lower limbs * having severe venous insufficiency or major injuries to their lower extremities * having neuromuscular disease * malignancy

Keywords: icu-aw nmes sarcopenia sepsis.
influence of perception of patients suffering of knee osteoarthritis regarding effectiveness of intra-articular injection

Conditions: Knee Osteoarthritis

Summary: introduction; reception must be understood as the offered attention within the relationship between a healthcare worker and the patient, including attitudes of inclusion, hearing, valorization of complains and identification of needs, being these individual collective. as a part of this process, communication is a primary and indispensable toll through which the healthcare team and the patient interchange information. objective: to evaluate the influence of perception of patients suffering of knee osteoarthritis over fear, catastrophizing of pain and effectiveness, related to intra-articular injection od corticosteroids. material and method: it will be performed a prospective, controlled and randomized study eith a blind evaluator on patients with symptomatic knee osteoarthritis submitted to joint injection. a hundred patients suffering of symptomatic knee osteoarthritis coming from the outpatient area of rheumatology division of federal university of sao paulo (unifesp) will be evaluated, 50 belonging to the intervention group (reception) and 50 to a control group.


Eligibility criteria:
inclusion criteria: * knee osteoarthritis according to american college of rheumatology criteria * no previous experience of joint injection * stable use of drugs for osteoarthritis treatment for at least 3 months * stable dose of corticosteroids, non hormonal anti-inflammatory and analgesics in the previous month * pain on knee between 3 and 7 in the visual analogue scale * signe the informed consent term * radiologic classification between 1-3 (kellgren and lawrence classification) exclusion criteria: * joint disease of different etiology * coagulation alteration * non treated fibromyalgia * litigation * diabetes mellitus and systemic arterial hypertension out of control * allergy of lidocaine or triamcinolone hexacetonide
understanding physical activity and quality of life in children and young people with chronic kidney disease

Conditions: Chronic Kidney Disease Stages 3-5

Summary: children and young people (cyp) with chronic kidney disease (ckd) say that physical activity, school, social activities and tiredness are the main issues they want to improve. as ckd in cyp is a rare disease, there is not much research into understanding these aspects, making it difficult to know how to support patients better. this project aims to investigate how physically active cyp with ckd are, and what psychosocial factors are affected by their illness. cyp aged 6-18 will take part in a battery of physical activity tests, par-take in an online survey looking at physical activity, quality of life, mental health, fatigue and strengths and difficulties, and take part in an interview to better understand what it is like to live with ckd.

the aim of this research is to document and evaluate the relationship between physical activity patterns and behaviours and psychosocial outcomes in children and young people with ckd. a second aim is to explore through qualitative methods contextual factors that may explain the type, direction and nature of relationships identified in the quantitative phase. this research will be conducted in multiple phases to maximise recruitment. 1. phase 1 consists of a battery of in-person physical functioning tests. 2. phase 2 consists of an online survey of validated questionnaires. 3. phase 3 consists of online or in-person interviews with cyp participants recruited through nhs scotland will take part in all 3 phases. only phase 2 (online survey) will additionally be disseminated through patient organisations across the uk to maximise recruitment. in phase 1, participants will take part in a battery of physical activity functioning assessments including multistage bleep tests, sit-up tests, and handgrip tests. participants will also be given an accelerometer measure to track movements over 7 days. participants taking part in this phase will also complete the phase 2 online survey which includes a physical activity, quality of life, fatigue, strength and difficulties, and mental health questionnaire. in phase 3, participants from phase 1 will return and take part in an interview to gain deeper insights into psychosocial influences and limitations in engaging in physical activity as well as gaining a better understanding of the impact of ckd on psychosocial wellbeing.

Eligibility criteria:
inclusion criteria: * cyp of school age between 6 and 18 years * living and receiving care in scotland for ckd * no clinical contradictions to physical function assessments exclusion criteria: * enrolment in other clinical trials in which treatment is masked/blinded * deemed to be clinically unstable by treating physician for participating in physical activity and exercise * severe cognitive impairment (as will be unable to give consent) * aged \ 18 years.

Keywords: children and young people chronic kidney disease physical activity psychosocial outcomes quality of life adolescents children exercise mental health
pilot study of metabolic syndromes and hiv infections in indian tibetans

Conditions: Metabolic Syndromes; HIV Infection

Summary: kaohsiung medical university chung-ho memorial hospital will provide a long-term free medical service in indian tibetans since july 2010. the investigators plan to investigate metabolic syndromes and hiv infection in indian tibetan community. the investigators will survey the prevalence and risk factors by means of hiv quick test and questionnaires. since there is lacking of prevalence survey for metabolic syndrome and hiv infection in tibetan colony of india, the investigiators will carry out this survey under the support and assistance of department of health of central tibetan government.


Eligibility criteria:
inclusion criteria: tibetan colony of india exclusion criteria: non-tibetan colony of india
perinatal arterial stroke treated with stromal cells intranasally

Conditions: Perinatal Arterial Ischemic Stroke; Neonatal Stroke

Summary: this study will assess safety and feasibility of bone marrow-derived allogeneic mscs, administered by the nasal route, in neonates who suffered from pais.

perinatal arterial ischemic stroke (pais) is an important perinatal cause of long-lasting neurodevelopmental problems. recent studies report an incidence of pais of 1 per 2300 full-term infants born alive. adverse consequences of pais include hemiplegia, cognitive dysfunction, epilepsy and speech problems. in 50-75% of infants, neonatal stroke leads to abnormal neuromotor and -developmental outcome or epilepsy. the estimated annual mortality rate of neonatal stroke is 3.49/100,000 annually. current treatment options for pais mainly focus on controlling convulsions and associated infections. there is no treatment available that leads to reduction of neonatal brain damage in this severely affected group of infants. this leads to life-long consequences of pais and forms a large burden for patients and society. the overall aim of this project is to meet this need by developing a cell based treatment strategy. animal models of neonatal brain injury provide evidence for the feasibility and efficacy of intranasal mesenchymal stromal cell (msc) application in the treatment of pais. additionally, results from human trials with mscs in the treatment of adult stroke or other pathologic conditions provide evidence that msc treatment is safe. this project aims at making the first step towards clinical application of mscs to treat pais. successful completion of this project will provide the first evidence of the safety and feasibility of mscs to treat brain damage in newborn infants. this study will assess safety and feasibility of bone marrow-derived allogeneic mscs, administered by the nasal route, in neonates who suffered from pais.

Eligibility criteria:
inclusion criteria: * (near-)term infants, ≥36+0 weeks of gestation, admitted to one of the dutch neonatal intensive care units, diagnosed with pais, confirmed by mri within 3 days after presentation with clinical symptoms. * pais as characterized by a predominantly unilateral ischemic lesion within the territory of the middle cerebral artery, with involvement of the corticospinal tracts, cortex, white matter and basal ganglia. * written informed consent from custodial parent(s). exclusion criteria: * any proven or suspected congenital anomaly, chromosomal disorder, metabolic disorder. * presence of an infection of the central nervous system. * no realistic prospect of survival, (e.g. severe brain injury), at the discretion of the attending physician.
anti-diabetic effects of persimmon leaf extract

Conditions: Prediabetes

Summary: the investigators performed a 8-week, randomized, double-blind, placebo-controlled crossover human trial to evaluate the efficacy and safety of persimmon leaf extract on blood glucose. the investigators measures changes in diabetes associated parameters, including fasting blood glucose, postprandial blood glucose, insulin, c-peptide and hba1c.


Eligibility criteria:
inclusion criteria: * age 20-75 years * fasting blood glucose (fpg) 100\~140 mg/dl or postprandial blood glucose (ppg) 140\~250 mg/dl exclusion criteria: * fpg more than 140 mg/dl * 2h ppg more than 200 mg/dl * type 1 diabetes or hba1c more than 9.0% * treatment with corticosteroids within the past 4 weeks * cardiovascular disease

Keywords: prediabetes blood glucose clinical trial
dpbrn patient satisfaction with dental restorations

Conditions: Patient Satisfaction

Summary: the purpose of this study was to administer two questionnaires. the first, a dental satisfaction questionnaire to assess patient satisfaction with a restoration visit using patients recruited from practices participating in the dental pbrn "reasons for replacement or repair of dental restorations" study. the second questionnaire (completed by the practitioner) was a brief single page questionnaire to evaluate the patient visit.

this study was to assess a comprehensive range of determinants of patient satisfaction following the restoration replacement or repair to study the relative contribution of each determinant towards overall patient satisfaction.

Eligibility criteria:
inclusion criteria: * participants directly involved in this study were patients who sought dental treatment in the practitioner investigators' practices * patient with replaced or repaired restorations placed in the treatment of permanent teeth who were also enrolled in the dpbrn "reasons for replacement or repair of dental restorations" exclusion criteria: * children younger than 13 years of age were excluded from this study because of issues related to comprehension and validity of responses

Keywords: patient satisfaction assessments dental caries dental materials