Kornimate/medical-research-clean huggingface dataset:
feasibility of a personalized sms intervention for insomnia

Conditions: Insomnia; Sleep Disorder

Summary: the goal of this research is to establish a proof of concept for optimizing and evaluating a personalized sms intervention based for individuals with chronic sleep problems.

insomnia is a pervasive disorder affecting approximately 10-40% of the u.s. population in a given year. in addition, insomnia has been identified as a transdiagnostic symptom that cuts across numerous other psychological disorders. interventions that target disordered sleep may attenuate symptomatic distress for a multitude of psychological disorders, making it a potentially potent intervention target with broad public health potential. despite the ubiquity of the problem, only a fraction of individuals who could benefit actually receive the most effective intervention for insomnia, cognitive behavioral therapy for insomnia (cbt-i). emerging research has pointed to the possibility of monitoring behavior and delivering personalized interventions to specific individuals via mobile devices. personalized and adaptive interventions delivered via short message service (sms) provide a relatively simple solution to prompt individuals to engage in personalized interventions outside the context of opening or downloading a mobile mental health app. the content of text messages have the capacity to modulate behavior via prompts, motivational messages, and "nudges." by using brief, motivational messages based on evidence-based treatment for sleep (e.g. cbt-i), there is the potential to reduce dysfunctional sleep patterns at scale.

Eligibility criteria:
inclusion criteria: * clinical insomnia (defined by scoring ≥ 15 on the insomnia severity index) exclusion criteria: * under 18 y.o. * unable to read or write in english * do not own a smart phone

Keywords: insomnia sleep
integrative sequencing in germline and hereditary tumours

Conditions: Hereditary Cancer Syndrome; High-Risk; Mutation; Germline Mutation

Summary: this study will investigate the utility of integrative sequencing of individuals and families at risk of hereditary cancer syndromes and will uncover novel contributors to tumourigenesis. integrative sequencing refers to: 1. whole genome sequencing (wgs) of the germline (inherited) genome 2. whole exome sequencing (wes) or targeted/panel sequencing of tumour(s) (somatic, tumour-specific mutations) 3. dna methylation (methylome) analysis of tumour(s) 4. rna sequencing (transcriptome) of tumour(s) eligible patients receiving genetic care at princess margaret cancer centre and the university health network may be approached by their genetic counsellor for participation in this study.


Eligibility criteria:
inclusion criteria: 1. patients must be ≥18 years of age 2. all patients and enrolled family members must have a signed and dated informed consent form all individuals at risk of a hereditary cancer syndrome without a known germline mutation from clinical genetic testing, will be eligible for this study. this includes: 1. individuals with multiple primary malignancies 2. families with a strong family history of cancer suggestive of a hereditary cancer syndrome 3. young individuals with cancer (10 years earlier than the age of onset of sporadic cases) and no identified gene mutation 4. rare cancer histologies individuals with an identified germline mutation will also be eligible for this study, if there are discordant family members suggesting additional genetic factors contributing to the variable familial phenotype. for example, a family composed of mutation carriers severely affected with cancers, and carriers unaffected with cancer. exclusion criteria: none.

Keywords: hereditary cancer syndrome high-risk mutation germline mutation rare cancer histology whole genome sequencing (wgs) whole exome sequencing (wes)
pharmacokinetic and pharmacodynamic properties of biod-123 and biod-125 compared to humalog® in subjects with type 1 diabetes including assessments of injection site toleration

Conditions: Diabetes Mellitus

Summary: the primary objective is to assess the speed of absorption of biod-123 and biod-125 and compare them to humalog.

the primary objective is to assess the speed of absorption of biod-123 and biod-125 and compare them to humalog. the secondary objectives are to assess other pharmacokinetic characteristics of biod-123 and biod-125 and compare those to humalog®, to assess pharmacodynamic characteristics of biod-123 and biod-125 and compare those to humalog®, and to evaluate the safety and tolerability of biod-123 and biod-125 compared to humalog®

Eligibility criteria:
inclusion criteria: 1. age: ≥18 - ≤70 years 2. bmi: ≥18 - ≤30 kg/m2 3. diagnosed with type 1 diabetes mellitus for at least 1 year 4. insulin antibody ≤10 μu/ml at screening exclusion criteria: 1. type 2 diabetes mellitus 2. history of \>2 severe hypoglycemic events within the 3 months prior to screening 3. serum c-peptide \>1.0 ng/ml 4. hemoglobin a1c (hba1c) \>10.0% 5. females who were breast feeding, pregnant, or intending to become pregnant during the study 6. a sexually active person who was not using adequate contraceptive methods 7. positive serology for human immunodeficiency virus (hiv), hepatitis b, or hepatitis c 8. abnormal ecg, safety lab, or physical examination results that were deemed clinically significant by the investigator
safety and efficacy study of de-104 ophthalmic solution to treat open-angle glaucoma or ocular hypertension

Conditions: Open-Angle Glaucoma; Ocular Hypertension

Summary: to investigate safety, efficacy, and the dose-response relationship of de-104 in lowering intraocular pressure in japanese and non-japanese subjects with primary open-angle glaucoma or ocular hypertension.


Eligibility criteria:
inclusion criteria: * provided signed, written informed consent. * 18 years of age and older. * diagnosed with primary open-angle glaucoma or ocular hypertension. * if a subject is a female of childbearing potential she must utilize reliable contraceptive throughout the study, and must have a negative urine pregnancy test prior to enrollment into this study. exclusion criteria: * females who are pregnant, nursing or planning a pregnancy, or females of childbearing potential who are not using a reliable method of contraception. * presence of any abnormality or significant illness that could be expected to interfere with the study.
electrographic seizure management and neurobehavioral outcomes in critically ill children

Conditions: Seizures

Summary: electrographic seizures are common in critically ill patients leading to increased use of resource-intense continuous eeg monitoring for seizure identification and management. when identified, electrographic seizures are generally treated with anti-seizure medications, but there are very limited data available regarding optimal treatment in terms of the efficacy or safety of specific anti-seizure medications or overall management strategies. this is a single-center prospective observational study. the investigators aim to: (1) track critically ill patients undergoing clinically indicated eeg monitoring and seizure management to identify risk factors for electrographic seizures, (2) create prediction models guiding eeg monitoring resources to the patients at highest risk for seizures, and (3) evaluate our current management strategy in terms of safety.

context: electrographic seizures are common in critically ill patients leading to increased use of resource-intense continuous eeg monitoring for seizure identification and management. when identified, electrographic seizures are generally treated with anti-seizure medications, but there are very limited data available regarding optimal treatment in terms of specific medication selections or overall management strategies. the children's hospital of philadelphia (chop) has a formal icu eeg monitoring pathway aiming to standardize eeg monitoring and seizure management. this is a single-center prospective observational study of patients undergoing clinically indicated eeg monitoring to identify risk factors for electrographic seizures and create prediction models guiding limited eeg monitoring resources to the patients at highest risk for seizures, and also to evaluate the current seizure management strategy in terms of safety. objectives: the primary objective is to identify risk factors for electrographic seizures in critically ill patients and use these risk factors to create and validate a seizure prediction model. the secondary objective is to evaluate the safety of a targeted and timely electrographic seizure identification and management strategy among critically ill patients guided by a chop icu eeg monitoring pathway. study design: single center observational study of consecutive patients undergoing clinically indicated eeg monitoring. setting/participants: single-center study of critically ill children in the pediatric icu at chop undergoing clinically indicated eeg monitoring and seizure management.

Eligibility criteria:
inclusion criteria: 1. care in the children's hospital of philadelphia pediatric icu. 2. clinically indicated continuous eeg monitoring. 3. age \> 1 month to 18 years. exclusion criteria: 1. admitted for phase 2 (intracranial) eeg monitoring. 2. intensivist expects to discontinue technological support in the next two days given underlying medical or neurological problems.

Keywords: seizures status epilepticus eeg monitoring
ba duan jin in treatment of attention deficit hyperactivity disorder

Conditions: Attention Deficit Hyperactivity Disorder

Summary: this study is designed to test if baduanjin training can reduce the hyperactive-impulsive symptoms of children with attention deficit hyperactivity disorder (adhd) compared to routine excise. investigators will also evaluate if the baduanjin training will positively affect chinese traditional medicine (tcm) symptoms compared to controls and if these impacts are related to the change of the executive function.

adhd is a common neurodevelopmental disorder characterized by a persistent pattern of inattention and/or hyperactivity and impulsivity, resulting in functional impairment in multiple settings. the prevalence in china is estimated to be 6.26%. from the point of chinese traditional medicine (tcm), adhd can be divided into 4 categories according to the symptom differentiation in tcm. aerobic exercise is known to improve executive function (ef) performance, which is known as the core deficit of adhd, therefore reduce adhd symptoms. aerobic exercise with the component of self-control and development of character is reported to improve ef. baduanjin is one of the aerobic exercises that has been handed down since the northern song dynasty, serving as chinese physical and breathing exercises. the eight movements of baduanjin are required to be gentle, slow, elastic and appropriate which not only require the practitioner to control physical activity but also require a combination of cognitive activities. researchers found that baduanjin has a positive protective effect on cognitive function such as selective attention in patients with mild cognitive impairment adults. therefore, investigators designed the baduanjin training system. this is a combination of a physical and cognitive training program and a video game with a motivation system, interesting and engaging for children with adhd to practice on.

Eligibility criteria:
inclusion criteria: * diagnosed with adhd, combined presentation or predominantly hyperactive-impulsive presentation * doctor rated snap-iv hyperactivity/impulsivity score≥12 * full-scale intelligence quotient\>=80 (wechsler intelligence scale for children-iv) * resident in shanghai，zhejiang province and jiangsu province, parents and children agree to participate in the intervention exclusion criteria: * using psychiatric medication other than methylphenidate * attending any other type of regular physical exercises except the gym class in school during the intervention period * accepting any type of psychological treatment during the intervention * comorbid with epileptic disorder or other existing physical disorder, tourette syndrome, autism spectrum disorder, learning disorder, mood disorder, psychiatric disorder, or under suicidal risk * attending any other clinical research at the same time

Keywords: chinese traditional medicine
plasma transthyretin levels and risk of type 2 diabetes mellitus and impaired glucose regulation

Conditions: Type 2 Diabetes; Impaired Glucose Regulation

Summary: objective: to investigate the association between plasma transthyretin levels and risk of newly diagnosed type 2 diabetes mellitus (t2dm) and impaired glucose regulation (igr) in a chinese population. design: we performed a case-control study, including 1,244 newly diagnosed t2dm patients, 837 newly diagnosed igr patients, and 1,244 individuals with normal glucose tolerance (ngt). the diagnostic criteria were recommended by world health organization in 1999. all cases were recruited from patients who, for the first time, received a diagnosis of t2dm in the department of endocrinology, tongji hospital, tongji medical college, wuhan, china, from december 2010 to december 2016. concomitantly, general population undergoing a routine health checkup in the same hospital were enrolled as controls. the inclusion criteria were age ≥ 30 years, bmi \< 40 kg/m2, and no history of diagnosis of diabetes or receiving pharmacological treatment for hypertension and hyperlipidemia. participants with clinically significant neurological, endocrinological, psychological or other systemic diseases, as well as acute illness or chronic inflammatory or infectious diseases, were excluded from the present study. written informed consent was obtained from each participant. besides, cases were stringently matched to controls in a 1:1 ratio, based on sex and age (± 3 years). all participants enrolled were of han ethnicity, and gave a commitment of taking no medication known affecting glucose tolerance or insulin secretion before participating in the study. fasting blood samples were collected in edta-anticoagulative tubes and separated for plasma within 1 h. then plasma was kept at -80℃ prior to analyses. plasma transthyretin levels were measured by bs 200 autoanalyser (mindray, shenzhen, china) using immunoturbidimetric method.


Eligibility criteria:
inclusion criteria: * age ≥ 30 years, bmi \< 40 kg/m2, and no history of diagnosis of diabetes or receiving pharmacological treatment for hypertension and hyperlipidemia exclusion criteria: * clinically significant neurological, endocrinological, psychological or other systemic diseases, as well as acute illness or chronic inflammatory or infectious diseases. incomplete basic information.

Keywords: transthyretin type 2 diabetes impaired glucose regulation
stroke education intervention trial - pilot

Conditions: Ischemic Stroke; Intracranial Hemorrhage; Transient Ischemic Attack

Summary: the objectives of the trial of a medication-coach program for patients with stroke or transient ischemic attack are to pilot test the study design, the intervention components and the data collection forms and refine them for a larger trial whose goal will be to improve long-term adherence to stroke prevention medications.


Eligibility criteria:
inclusion criteria: * patients at wake forest university baptist medical center (wfubmc) over age 18 * diagnosed with acute ischemic stroke, transient ischemic attack or intracranial hemorrhage * provide consent to participate exclusion criteria: * discharged to nursing home, acute rehabilitation center, inpatient hospice, or other acute hospital * homeless * non-english speakers * patient and proxy unable to participate in telephone conversation

Keywords: stroke patient education medication adherence
: association of melatonin levels and light and noise isolation in icu

Conditions: Cranial Nerve Diseases

Summary: melatonin is secreted from the epiphyseal gland with a circadian rhythm and is known to be anti-inflammatory. in this study, it is planned to investigate the effect of sleep disruptions on melatonin levels and inflammation parameters in intensive care patients underwent transcranial surgery

patients with glasgow coma scale (gks) \>14, american society of anesthesiologist (asa) i-iii, intensive care patients underwent transcranial surgery will be included patients will be randomly allocated by a computer generated random numbers list into two groups. patients with sleep disruptions (group i) (exposed to ambient light and noise) and patients without sleep disruptions (group ii) (eyes closed with patch and ear plugged; between 24:00-06:00) melatonin levels will be measured by urine 6-sulfatoxymelatonin (a-mt6) levels, which is a product of melatonin degradation at 07:00 am preoperative and postoperative day 1 and day 3. plasma interleukin-1 (il-1), interleukin- 6 (il-6),c-reactive protein (crp) levels will be measured at 07:00 am preoperative and postoperative day 1and day 3.

Eligibility criteria:
inclusion criteria * asa 1-3 * glasgow coma scale(gcs) \>14 exclusion criteria: * glasgow coma scale(gcs) \<14 * patients who do not understand the questions, not awake * patient who treated with hormones * patient with infection or inflammatory disease

Keywords: melatonin interleukin transcranial surgery intensive care
weekly use first-generation egfr-tki in the treatment of egfr-tki acquired resistance non-small cell lung cancer (nsclc)

Conditions: EGFR-TKI Resistant Mutation

Summary: egfr-tki is the main is the first line therapy for local advanced or metastatic non-small cell lung cancer with egfr gene mutation. the median progression free survival time is around 11 months with the first generation egfr-tki. patients with acquired resistance with first generation egfr-tki usually with egfr exon 20 mutation (t790m). change the drug administration maybe prolong patients pfs and evently prolong os.

1st generation egfr-tki has reversible binding to egfr, it also bind to t790m in a high dose which is account about 60% patients acquired resistance to the drug. resistance patients may be benefit to a bolus drug use to block t790m gene.

Eligibility criteria:
inclusion criteria: * nsclc with egfr mutation progressed after first generation egfr-tki, or progressed after chemotherapy and 1st generation egfr-tki or progressed after 1st generation egfr-tki and chemotherapy. expected survival more than 3 months with a ecog ≤3. exclusion criteria: * liver function (alt, ast) and renal function 2 times higher than normal limit; ipd; uncontrolled diarrhea; severe anemia.

Keywords: progression-free survival
efficacy of tecar therapy in patients with knee osteoarthritis

Conditions: Knee Osteoarthritis; Energy Transfer Capacitative and Resistive Therapy

Summary: objective: the aim of the present study was to investigate the treatment efficacy of tecar therapy, a modern application that has been increasingly used in recent years, compared to conventional physical therapy applications in the treatment of knee osteoarthritis, according to the evaluation of the clinical findings of patients. methods: a total of 54 patients, aged between 40 and 75 years, were randomly divided into two groups. both groups received cpt. group 2 received tecar therapy in addition to cpt, applied three times a week for two weeks, for a total of 6 sessions. all patient's knee joint range of motion (rom) was measured goniometrically, isometric quadriceps muscle strength was measured, and pain levels were assessed using the visual analog scale (vas), and disability levels were assessed using the western ontario and mcmaster universities arthritis index (womac) before treatment, at the end of treatment, at 1 month, and at 3 months.


Eligibility criteria:
inclusion criteria: * 3 months of conservative treatment for unresponsive knee pain * kellgren-lawrence grade 2-3 on radiographic evaluation * agreed to participate in the study. exclusion criteria: * history of physical therapy (electrotherapy/exercise) in the past 3 months * intra-articular injection therapy in the past 3 months, * history of surgery or trauma to the affected knee * inflammatory or neurological disease affecting the lower extremities * active vasculitis or severe peripheral vascular disease * pregnancy or lactation * diagnosed restless legs syndrome * neoplasia * local sensory impairment, * local or systemic acute infections * severe osteoporosis * pacemaker * psychiatric disorder and cognitive impairment.

Keywords: knee pain, osteoarthritis, capacitative and resistive energy transfer therap
breast study investigating a new light technique to monitor changes in breast tissue density

Conditions: Breast Cancer

Summary: the purpose of this study is to test the ability of a technique called transillumination breast spectroscopy (tibs) to monitor an individual's breast density changes over time.

breast density is an established physical risk factor for breast cancer, applicable to the entire female population in a pre-breast-screening program and, unlike other risk factors, was shown to be affected by an intervention treatment. high breast tissue density is associated with increased risk of breast cancer. transillumination breast spectroscopy (tibs) uses a white light to provide spectral information on breast tissue density and composition (e.g. water, lipid, hemoglobin and other biomolecules). the overall goal of the tibs program is to develop a technique that can identify individuals at high risk for breast cancer who would benefit most from improved screening methods and a risk reducing intervention (e.g. diet and lifestyle changes) and can monitor the efficacy of the risk reducing intervention itself in an individual. in a previous study, we demonstrated a high correlation between breast density assessed by tibs and density identified by x-ray mammography. the current study is testing tibs ability to monitor changes in an individual's breast density over time

Eligibility criteria:
inclusion criteria: * be in good health and able to provide consent * be between 25 and 45 years of age * be pre-menopausal * are willing to come in to princess margaret hospital (toronto, ontario, canada) for up to 12 visits at intervals of about three months exclusion criteria: * have had a full term pregnancy * have had breast biopsy * have had breast augmentation or reduction

Keywords: breast transillumination spectroscopy optical transillumination spectroscopy breast cancer risk