Kornimate/medical-research-clean huggingface dataset:
assessment of ltp-like pain amplification in chronic low back pain patients

Conditions: Low Back Pain

Summary: the present study is aimed to assess the ltp-like pain amplification in chronic low back pain patients to explore the central and peripheral effect for pain ltp.

this study is a cross-sectional study. two groups, including low back pain group and healthy subjects group will be arranged in this study. 50 subjects will be recruited in each group, the healthy subjects were matched for sex and age in relation to the low back pain group. conditioning electrical stimulation (100 hz, repeated 5 times with 10 s intervals, 500 impulses) using circular pin electrodes will be used in both groups to induce ltp-like pain amplification. the pain intensity changes to pinprick and light touch stimuli will be compared between two groups.

Eligibility criteria:
1. chronic low back pain patients inclusion criteria: * age 21-80 years old. * people must have experienced low back pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (nrs) in the last 7 days. exclusion criteria: * age below 21 or over 80 years old. * patients were excluded if they had taken pain medications on the day of the assessment or if they had serious spinal pathologies, such as fractures, tumors or inflammatory diseases, such as ankylosing spondylitis, nerve root compromise confirmed by clinical neurological tests or severe cardiorespiratory diseases. those who were pregnant, patients with cancer and those with a cardiac pacemaker were also excluded. 2. healthy volunteers. inclusion criteria: * age 21-80 years old. * these participants must not have presented episodes of low back pain for more than 7 days in the last 12 months. exclusion criteria: * age below 21 or over 80 years old. * these participants have presented episodes of low back pain for more than 7 days in the last 12 months.

Keywords: low back pain long-term potentiation hyperalgesia allodynia
comparison of laryngeal mask and i-gel to laryngoscope by novice operators in simulated difficult airway

Conditions: Airway Obstruction

Summary: the use of laryngeal mask airway or i-gel to manage airway may improve success rates, especially in difficult situations more than tracheal intubation.

this study compares the insertion success rate and insertion time among the proceal laryngeal mask airway, i-gel, and tracheal tube. following a short lecture, airway novices try to insert proceal laryngeal mask airway, i-gel, and tracheal tube into manikin with difficult laryngoscopy scenarios.

Eligibility criteria:
inclusion criteria: * medical student * nurse * no experience of insertion using tracheal tube, i-gel, and laryngeal mask airway exclusion criteria: * experience of insertion using tracheal tube, i-gel, and laryngeal mask airway
efficacy and safety of sr121463b in patients with syndrome of inappropriate antidiuretic hormone secretion

Conditions: Inappropriate ADH Syndrome; Hyponatremia

Summary: to assess the efficacy of sr121463b in correcting hyponatremia in patients with syndrome of inappropriate antidiuretic secretion (siadh).to assess the long-term efficacy of sr121463b in maintaining normal levels of serum sodium in patients with siadh. to assess the safety and tolerability of sr121463b in patients with siadh. the double blind period is followed by an open label extension study with flexible doses of satavaptan.


Eligibility criteria:
inclusion criteria: * male or female patients aged 18 years and higher. * siadh (the diagnosis of siadh is based on several criteria including true serum hypoosmolality, inappropriate urinary osmolality, clinical euvolemia, elevated urinary sodium excretion while on normal salt and water intake, and normal renal, adrenal, and thyroid functions: drug induced siadh will be limited to carbamazepine or derivatives and antidepressants in patients in whom these drugs cannot be discontinued or easily replaced by other drugs) * serum sodium between 115 and 132 mmol/l (at least two consecutive serum sodium levels of at least 24 hours apart, from day -6 to day -1); for sodium levels between 125 and 132 mmol/l, the spontaneous serum sodium increase between the two assessments on day -1 should be \< 4 mmol/l * urinary osmolality \>200mosm/kg h2o * urinary sodium \> 30 mmol/l exclusion criteria: * patients with acute postoperative siadh * presence of dilutional hyponatremia in hypervolemic states such as congestive heart failure and liver disease with ascites * presence of signs of hypovolemia (e.g., orthostatic hypotension, increased serum urea nitrogen, increased serum albumin, increased hematocrit, ...) * administration of other v2 receptor antagonists or demeclocycline or lithium within one month, thiazides diuretics or spironolactone within 15 days, and urea or loop diuretics within two days prior to study drug administration * patients with known treated or untreated adrenal deficiency * presence of untreated hypothyroidism * presence of uncontrolled diabetes with fasting glycemia \> 200 mg/dl (\> 11.09 mmol/l) * presence of clinical and/or electrocardiographical signs of acute myocardial infarction or acute ischemia, or nay other clinically significant abnormality according to the investigator on a 12 lead ecg recording * administration of inducers of cyp3a4, phenytoin, rifampin, saint john's wort) or potent and moderate inhibitor so cyp3a4within two weeks prior to study drug administration * inadequate hematological, renal and hepatic functions: hemoglobin (hb) \ 175 µmol/l, alt and /or ast \>2x upper limit of normal * qtcb \> 500 ms * serum potassium \> 5 mmol/l

Keywords: inappropriate adh syndrome hyponatremia
efficiency of kinesio taping in chronic lateral epicondylitis

Conditions: Tendinopathy, Elbow

Summary: lateral epicondylitis is a degenerative tendinosis of the extensor carpi radialis brevis muscle and is the most common work/sports-related chronic musculoskeletal problem affecting the elbow. this randomized, double-blinded, controlled study aimed to evaluate the short term and residual effectiveness of the kinesio taping method on pain, grip force, quality of life, and functionality.

fifty patients diagnosed with chronic unilateral lateral epicondylitis with a symptom duration of at least 12 weeks. the study group received a true inhibitor kinesio taping while the control group received sham taping for the first four weeks. in both groups, progressive stretching and strengthening exercises were given as a home program for 6 weeks. patients were assessed with the numerical rating scale (nrs), cyriax resistive muscle test evaluation, maximal grip strength, prtee (patient- rated tennis elbow evaluation), and sf-36 (short form-36) by the first assessor who was blinded to taping types.

Eligibility criteria:
inclusion criteria: * having pain on or near the lateral epicondyle and increases with pain at least one of the following provocations tests for lateral epicondylitis -resisted wrist extension (cozen's test), resisted elbow supination (mill's test) and 3rd finger extension (maudley's test), * unilateral elbow pain at least 12 weeks, * not received injection therapy to the elbow in the last six weeks, * not received a physical therapy program in the last three months, * presence of normal elbow radiographic findings, * normal elbow joint range of motion, * having no neurological deficits exclusion criteria: * patients with degenerative joint disease, * radial tunnel syndrome, * cervical nerve root compression, * pain reflected from the neck, shoulders, * wrist, radiohumeral joint osteochondritis dissecans, * tendon rupture, * osteoporosis, infection, * malignancy, * inflammatory disease, * pregnant women

Keywords: kinesio taping lateral epicondylitis residual effect
low-carb/time-restricted feeding protocol in insulin-using type 2 diabetics

Conditions: Type2 Diabetes

Summary: the current paradigm of type 2 diabetes treatment relies heavily on expensive pharmacotherapy even though lifestyle factors are at the root of the condition. this study is designed to assess the feasibility of a low carbohydrate diet coupled with a time restricted feeding intervention to improve participant sensitivity, reducing their need for insulin. 20 participants will be invited to enroll from the 20 s park st clinic in madison, wi and remain on study for up to 6 months.

the investigators will perform a prospective cohort study of 20 insulin-using type 2 diabetics who have primary care providers at 20 s park st clinic. participants will be recruited from the internal medicine practices at the clinic. the subjects will meet with dr. zimmermann (study clinician) to review time restricted feeding and low-carbohydrate diets as well as a strategy for decreasing insulin doses. calls from dr. zimmermann's clinic nurse will occur daily until blood glucose levels stabilize to manage insulin decrease. participants will complete monthly logs of food intake times and meet with a dietician twice during the 6-month study. diabetes medication use will be reviewed, and hemoglobin a1c will be measured, at baseline and at 3 and 6 months. the participants' non-diabetic medical care will continue to be managed through their primary care physicians (pcps). specific aims: * demonstrate feasibility of the low carbohydrate/time restricted feeding (lc/trf) protocol * feasibility will be assessed based on participant compliance with time-restricted feeding and recommended carbohydrate intake, clinician time and clinic resources * determine effectiveness of the lc/trf protocol on diabetes care and quality of life * effectiveness on diabetes care will be evaluated using changes in a1c, insulin use, bmi, patient quality of life, and adverse events including hypoglycemia.

Eligibility criteria:
inclusion criteria: * patient of a primary care provider at 20 s park internal medicine clinic * insulin using type 2 diabetic * using glargine or detemir insulin for basal insulin dosing * self-administering insulin * hemoglobin a1c 7-10%. * stable diabetes regimen for \>3 months * demonstrated reliability with glucose monitoring, a1c checks * bmi 25-35 exclusion criteria: * history consistent with type 1 diabetes * using concentrated insulin (u200 or u300) * living in a skilled nursing facility * unwilling or unable to do frequent (3x daily) blood glucose checks * egfr (estimated glomerular filtration rate) \< 30 ml/min per 1.73 m2 * currently on steroids or warfarin * hospitalized within 3 months * symptomatic heart failure * weight loss \>10% in last six months * history of organ transplantation * pregnant/trying to become pregnant/breast feeding

Keywords: low carbohydrate diet time restricted feeding insulin sensitivity
outcome of proximal femur replacement at a tertiary care hospital

Conditions: Outcome, Fatal

Summary: this is a retrospective review of all patients who underwent pfr for either bipolar hemiarthroplasty or total hip replacement

retrospective review of all patients who underwent pfr for either bipolar hemiarthroplasty or total hip replacement will be conducted all patients that fall in the selection criteria from 2009 to 2018 will be included as part of this study will be selected patients are identified using medical record numbers. a questionnaire containing questions on demographics of the patients which includes their age, sex and co morbids. furthermore, the cause of fracture, time from the fracture to presentation in the emergency room, time from the presentation to er to the time patient was in the operating room would be noted. duration of the surgery. the weight bearing status in the ward and follow-up would be noted. functionality of the patient; which is that how much patients are able to carry their normal daily routine work would also be noted from the medical records. collected data will be analysed using statistical package for social sciences (spss, inc, chicago, il, usa). results will be recorded as frequencies, means, standard deviation (sd) and p-values while statistical tests will be applied for comparative reasons. for all purposes a p-value of 0.05 will be considered as the level of significance.

Eligibility criteria:
inclusion criteria: * all patients, regardless of race, gender, age and co-morbids, who were treated with proximal femur fracture with any of the following variables: poor bone quality bone loss severe communition multiple comorbids failed hip surgery pathological fractures exclusion criteria: * the patient who weren't treated with proximal femoral replacemnt, those lost to follow up, those with missing record.

Keywords: proximal femur functional outcome fracture failed hip surgery
prp for glenohumeral osteoarthritis

Conditions: Shoulder Osteoarthritis

Summary: the glenohumeral joint is the third most common large joint to be affected by oa. conservative treatments include physical activity, corticosteroid injections, and medications. prp is an emerging treatment that has shown efficacy in different musculoskeletal conditions. the use of prp for glenohumeral oa has been described sparingly in the literature but has shown efficacy in a couple studies and case reports. however, all of the previous studies investigating prp for glenohumeral oa have focused on low-dose prp preparations (\~3x), and none have compared prp treatment to saline treatment. this study aims to compare outcomes following single injections of low-dose prp, high-dose prp, or saline in patients with glenohumeral osteoarthritis.


Eligibility criteria:
inclusion criteria: * 18-100 years old * average nrs pain greater than or equal to 5/10 as a direct result of glenohumeral osteoarthritis (any severity: mild, moderate, or severe) and/or chondral lesion or loss * at least 3 months of pain after onset of symptoms that has failed conservative treatments, including physical therapy * mri of the affected joint * transient relief of symptoms after a diagnostic intra-articular injection into the joint * email address or network access exclusion criteria: * inability to hold non-steroidal anti-inflammatory drugs for 2 weeks prior and 1 month after the injection * prior platelet-rich plasma injection * steroid injection within 3 months of the initial injection * hyaluronic acid within 6 months of the initial injection * involved in workers' compensation or active litigation involving the affected joint * history of plavix use * known uncontrolled systemic illness (uncontrolled diabetes, hiv, vasculitis, autoimmune/autoinflammatory disease) * presence of acute fractures or gross mechanical deformities * concurrent "uncontrolled" cervical disorders
small intestinal absorption in patients with chronic obstructive pulmonary disease and cor pulmonale

Conditions: Chronic Obstructive Pulmonary Disease; Cor Pulmonale

Summary: aim: to investigate whether patients with pulmonary hypertension have reduced absorption capacity compared to copd patients without cor pulmonale potentially due to venous obstruction in the portal vein system. the presence of cor pulmonale was determined by echocardiography. the concentration of d-xylose and zinc were measured in peripheral blood one, two and three hours after ingestion and used as markers of absorption. furthermore, urine was collected for five hours to determine the amount of excreted d-xylose.

background: cor pulmonale is a common complication to chronic obstructive pulmonary disease (copd), and may result in increased pressure in the inferior caval vein and stasis of the liver. the chronic pulmonary hypertension may lead to stasis in the veins from the small intestine and thereby compromise absorption of nutrients. aim: to investigate whether patients with pulmonary hypertension have reduced absorption capacity compared to copd patients without cor pulmonale. methods: absorption of d-xylose (25 g) and zinc (132 mg), administered as a single dose, was tested in 14 copd patients, seven with and seven without cor pulmonale. the presence of cor pulmonale was determined by echocardiography. the concentration of d-xylose and zinc were measured in peripheral blood one, two and three hours after ingestion and used as markers of absorption. furthermore, urine was collected for five hours to determine the amount of excreted d-xylose.

Eligibility criteria:
inclusion criteria: * a diagnosis of copd * clinically stable = unchanged medication for copd for at least 6 months exclusion criteria: * unable to understand danish * other clinically important heart-disease than chronic right heart changes presumably due to lung disease * clinically significant gastro-intestinal or kidney disease * diabetes * treatment with corticosteroids for at least 6 months.

Keywords: cor pulmonale copd malabsorption d-xylose zinc
does breastfeeding lower blood pressure in postpartum hypertensive patients

Conditions: Breastfeeding; Hypertension

Summary: the primary aim is to establish whether breastfeeding is associated with lowering blood pressure in hypertensive women.

patients included in this study will have chosen to breastfeed. 1. the investigators will identify patients that are planning to breastfeed from their intake questionnaire that all patients receive upon admission to labor and delivery. they will also identify breastfeeding patients while performing our postpartum rounding. 2. the investigators will perform a chart review to determine their co-morbidities and current medications. specifically, the patient information recorded will be age, parity, gestational age, delivery route, vital signs, medications, race, whether they are breastfeeding. of note, all of the individuals listed to participate in this study have routine access to the patient's charts since they will be working with the patients regardless of their participation in the study. 3. only hypertensive women will be included. hypertension is defined as persistent systolic blood pressure \> 140 and or persistent diastolic blood pressure \> 90. 4. once it has been determined that they have met the inclusion criteria for the study the investigators will ask the patient's attending physician if we can approach the patient and explain the study and obtain consent. 5. once consent is obtained, the investigators will inform the nurse. the patient will have her blood pressure taken prior to breastfeeding, during breastfeeding, and 1-2 hours after breastfeeding. this will occur 3 times in the postpartum period.

Eligibility criteria:
inclusion criteria: * the inclusion criteria include hypertensive women in the first 72 hours postpartum. the gestational age at delivery must be greater or equal to 34wk and the patient must be breastfeeding and/or pumping milk. the study will include patient's on anti-hypertensive. the study will also include patients receiving postpartum iv magnesium but they will have their blood pressure taken two times while on magnesium and two times after the magnesium has been discontinued. exclusion criteria: * the study will exclude patient's on dopamine agonist medications or hiv positive.
computational neuroscience of language processing in the human brain

Conditions: Language; Epilepsy

Summary: language is a signature human cognitive skill, but the precise computations that support language understanding remain unknown. this study aims to combine high-quality human neural data obtained through intracranial recordings with advances in computational modeling of human cognition to shed light on the construction and understanding of speech.

the neural architecture of language is the foundation for the highest form of human interaction. prior work has identified a network of frontal and temporal brain areas that selectively support language processing, but the precise computations that underlie our ability to extract meaning from sequences of words have remained unknown. the standard approaches in human cognitive neuroscience lack the spatial and temporal resolution necessary for precise comparisons to computational models. to bridge this gap in knowledge, neural responses to language stimuli will be collected from epileptic patients undergoing intracranial monitoring. overall, these data will be used to identify cortical maps of different linguistic manipulations and to better understand properties of the human language network.

Eligibility criteria:
inclusion criteria: * clinical indications to proceed with intracranial monitoring involving the left cerebral hemisphere, as determined by a multidisciplinary epilepsy surgery team * the ability to comply with test directions and provide informed consent * between ages 18 - 85 exclusion criteria: * inability to understand or perform the task outlined in the protocol, or who are unwilling or unable to participate

Keywords: language computational neuroscience epilepsy
prospective performance analysis of the exair(tm) prolapse repair system in the treatment of pelvic organ prolapse

Conditions: Pelvic Organ Prolapse

Summary: the aim of the study was to assess the role of the exair transvaginal mesh system to correct pelvic organ prolapse from a subjective and objective standpoint. subjects treated with the exair transvaginal mesh for prolapse between june 2013 and august 2015 was analyzed. subjects with uterine prolapse underwent vaginal mesh hysteropexy. there were no hysterectomies done for uterine prolapse in this study. a composite score that included subjective criteria of absence of a bothersome bulge, no prolapse below the hymen and no retreatment was used to assess success.transvaginal exair mesh hysteropexy offers a good option for the management of large uterine prolapses precluding the need for a hysterectomy.


Eligibility criteria:
inclusion criteria: * subjects desiring surgery for stage ii or greater prolapse on the pelvic organ prolapse quantification system assessment (pop-q) and symptoms specific to pelvic organ prolapse mainly bothersome perception of a vaginal bulge exclusion criteria: * any physical or mental limitation that precluded their participation or inability to give informed consent

Keywords: pelvic organ prolapse exair transvaginal mesh