Kornimate/medical-research-clean huggingface dataset:
a pilot study of the effect of high protein supplement and exercise therapy on preservation of skeletal muscle mass and quality of life in patients with gastric cancer and pancreatic cancer treated with chemotherapy

Conditions: Gastric Cancer; Pancreatic Cancer

Summary: for gastric and pancreatic cancer patients scheduled for primary chemotherapy, we would like to report muscle mass preservation and improvement in quality of life in chinese characters that received only exercise therapy and high protein supplements at the same time

sixty patients with gastric and pancreatic cancer will be eligible, and 30 patients will be randomly assigned to the exercise therapy + high protein supplement group and 30 patients to the exercise therapy + placebo supplement group.

Eligibility criteria:
inclusion criteria: 1. has provided signed written informed consent 2. has a histologically confirmed gastric or pancreatic cancer 3. has a patient scheduled for chemotherapy - patients who are scheduled to be treated with ts-1 or xelox for gastric cancer-adjuvant chemotherapy - patients scheduled for primary chemotherapy for pancreatic cancer-progressive/transitional diseases exclusion criteria: 1. age under 19 or over 90 year of age 2. eastern cooperative oncology group (ecog) ≥ 2 3. patients with severe malnutritional evaluation (pg-sgac) 4. any of the following within 3 months prior to study recruitment: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, nyha class iii or iv congestive heart failure, stroke or transient ischemic attack. 5. a person with previous uncontrolled seizures, central nervous system or psychological disorders 6. have uncontrolled active infection or sepsis 7. have deep vein thrombosis occurs within 4 weeks prior to the start of test recruitment 8. severe acute or chronic conditions that may reduce the patient's ability to participate in clinical trials or make it difficult to interpret clinical trial results 9. pregnant or lactating women. pregnancy test results are positive in childbearing women 10. gastrointestinal obstruction, malabsorption syndrome, or diseases that significantly affect digestive functions
incidence and risk factors of symptomatic epidural hematoma after cervical spine surgery

Conditions: Symptomatic Epidural Hematoma After Cervical Spine Surgery

Summary: the incidence and correlation of symptomatic epidural hematomas after cervical spine surgery was reviewed and analyzed, then it will provide reference to avoid the occurrence of this complication for the future clinical work.

43 patients with symptomatic epidural hematoma after cervical spine surgery were enrolled in the peking university third hospital from january, 2009 to february, 2017. 86 patients without symptomatic epidural hematoma after cervical spine surgery during the same period were randomly selected as the control group. demographic information (including gender, age, previous history, smoking history, etc.)，disease parameters (diagnosis, mjoa(modified japanese orthopaedics association) score, ndi(neck disability index) score)，laboratory and imaging parameters (including platelet, coagulation function, albumin, and opll)，segments，treatment parameters (surgical method, number of surgical segments, operative time, intraoperative blood loss, anesthesia time, whether to use implants) and postoperative conditions (including the time of hematoma occurrence, diagnostic method, emergency debridement operation time, patient improvement before and after debridement) were collected.firstly, risk factors for symptomatic epidural hematoma after cervical surgery were selected by univariate analysis,then independent risk factors were screened by multiple logistic regression analysis.

Eligibility criteria:
inclusion criteria: * patients with clinically and radiologically confirmed cervical spondylosis. * cervical spine surgery was performed in our hospital exclusion criteria: * cervical trauma combined with fracture and dislocation. * cervical cancer. * cervical spine infection * upper cervical spine surgery alone

Keywords: epidural hematoma cervical spine surgery risk factors
longitudinal evaluation of hip cartilage degeneration: fai

Conditions: Femoroacetabular Impingement

Summary: femoroacetabular impingement (fai) is one of the most common mechanisms leading to the development of early cartilage and labral damage in the non-dysplastic hip. anatomic abnormalities of the proximal femur and/or acetabulum result in repetitive injury during dynamic hip motion, leading to abnormal regional loading of the femoral head-neck junction against the acetabular rim. the resulting damage to the cartilage, labrum, and surrounding capsular structures predispose the patient to developing hip pain and early osteoarthritic changes. clinically, patients with fai are a heterogeneous group, with a wide array of presentation from pain to instability that may or may not be related to activity. to date no studies have identified specific prognostic indicators associated with successful surgical treatment of fai, leaving surgeons without adequate criteria to determine which patients are best suited for arthroscopy. the investigators propose to address this critical knowledge gap by identifying the patient characteristics and morphological features of the hip that are associated with the optimal clinical outcomes in patients undergoing hip arthroscopy or non-operative management for treatment of suspected fai in order to establish a treatment algorithm for fai patients.


Eligibility criteria:
inclusion criteria: * all patients 35 years of age or younger enrolled in the hss hip preservation registry prior to september 30, 2016 with an mri confirmed diagnosis of fai will be eligible for inclusion in this study regardless of surgery status. * patients who agree to participate must complete a baseline questionnaire consisting of: 1) modified harris hip score (mhhs), an overall measure of hip condition; 2) the hip outcome score (hos), a measure developed specifically for younger active patients that measures quality of life and levels of sports and recreation; and 3) international hip outcome tool (ihot33), a newly developed hip specific outcome score, which measures a number of subscores relating to physical and social functioning with hip problems. exclusion criteria: * patients over age 35 will be excluded as the focus of this study is early changes that may predispose to later degenerative changes. * patients undergoing revision hip arthroscopy as their first treatment in the registry will not be eligible, as these are patients who have failed initial therapy. * patients with no complete questionnaires at any time point will be excluded.
clinical analysis of two toric intraocular lenses

Conditions: Cataract; IOL

Summary: purpose: comparison of two torical intraocular lenses with differents haptic design in patients with cataract. methods: in this prospective, randomized clinical trial 120 eyes of 60 patients underwent phacoemulsification. in patient's eyes the tecnis torical iol (abbott medical optics) or the at torbi torical 709 mb iol (zeiss medical ag) were randomly implanted. three months after surgery visual acuity, rotation stability and astigmatism correction were evaluated.


Eligibility criteria:
inclusion criteria: * age related cataract on both eyes * corneal astigmatism 1,0- 4,0 d * potential postoperative visus 1,0 * no other ocular pathology as cataract * age 18 - 80 * written informed consent to surgery and participation in the study exclusion criteria: * pregnancy, breastfeeding * amblyopy, diabetic retinopathy, uveitis or other relevant ophthalmologic diseases * optical media disturbances due to: corneal and vitreal opacity, pex * irregular astigmatism measured with corneal topography (visante-omni), keratoconus * ≥ 10 degrees difference between the axis of keratometry measurement of the iol master and the simulated k reading of the corneal topograph (visante-omni) * trauma, ocular surgery performed within 6 months * traumatic cataract * potential postoperative visus under 1,0

Keywords: toric iol
a study to assess the safety, tolerability and efficacy of ionis-agt-lrx, an antisense inhibitor administered subcutaneously to hypertensive participants with controlled blood pressure

Conditions: Mild Hypertension

Summary: this was a phase 2, double-blind, randomized, placebo-controlled study of ionis-agt-lrx conducted in mild hypertensive participants.

participants were randomized in a 2:1 ratio to receive a once-weekly subcutaneous treatment and an additional loading dose on study day 3 with either ionis-agt-lrx or placebo for 6 weeks. all participants completed a 13-week post-treatment period.

Eligibility criteria:
inclusion criteria 1. females must be non-pregnant and non-lactating, and either surgically sterile or post-menopausal. 2. males must be surgically sterile or, abstinent or, if engaged in sexual relations with a woman of child-bearing potential, the participant or the participant's non-pregnant female partner must be using a highly effective contraceptive method 3. body mass index (bmi) ≤ 35.0 kg/m2 4. participant must have been diagnosed with essential hypertension for a minimum of 3 months prior to screening 5. at screening, on a stable regimen of antihypertensive medications for at least 1 month prior to screening 6. agree to conduct at home blood pressure (bp) and heart rate (hr) monitoring three times weekly and document the average of the triplicate measurements assessed on a day in the patient diary exclusion criteria 1. clinically-significant (cs) abnormalities in medical history, screening laboratory results, physical or physical examination that would render a participant unsuitable for inclusion 2. the use of the following at time of screening and during the course of the study: 1. other medications for the treatment of hypertension (e.g., clonidine, guanfacine, guanabenz, alpha-methyldopa, hydralazine, minoxidil, diazoxide, renin inhibitors) 2. medications that also may cause hyperkalemia (e.g., cyclosporine or tacrolimus, pentamidine, trimethoprim-sulfamethoxazole, all heparins) 3. oral or subcutaneous anticoagulants (e.g., warfarin, rivaroxaban, apixaban, heparin, lovenox) 4. organic nitrate preparations (e.g., nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, or pentaerythritol) 5. sildenafil, tadalafil, vardenafil 3. unwilling to discontinue antihypertensive mediations during wash out (wo) and treatment period of study 4. participant has a history of secondary hypertension 5. unstable/underlying cardiovascular disease defined as: 1. any history of congestive heart failure (nyha class ii-iv) 2. any history of previous stroke, transient ischemic attack, unstable or stable angina pectoris, or myocardial infarction prior to screening 3. a history or evidence of long qt syndrome 4. any cs active atrial or ventricular arrhythmias 5. any history of coronary bypass or percutaneous coronary intervention

Keywords: hypertension hypertensive agt angiotensinogen blood pressure high blood pressure
retrospective, non-interventional study of depo-eligard®.

Conditions: Prostate Cancer

Summary: study will evaluate the real-world effectiveness of depo-eligard® after six months of treatment

the study will provide data on the tolerance, safety and acceptance of depo-eligard® (leuproreline acetate) when used in routine clinical practice. data on efficacy parameters such as testosterone, psa levels, symptoms and treatment failure, if available will be collected.it will reflect the way depo-eligard® is used in routine clinical practice and how psa, testosterone levels, symptoms and treatment failure, are used as parameters in the treatment for prostate cancer. patient data will be collected after a treatment period of six months.

Eligibility criteria:
inclusion criteria: * patients having been prescribed depo-eligard® in accordance with the terms of the marketing authorization * patients on treatment with depo-eligard® for at least six months * written consent has been obtained

Keywords: prostate cancer
improving prematurity-related respiratory outcomes at vanderbilt

Conditions: Preterm Birth; Bronchopulmonary Dysplasia; Chronic Lung Disease of Prematurity

Summary: the goal of improv is to identify molecular mechanisms that contribute to lung injury and long-term breathing problems in preterm infants by investigating two interrelated biochemical pathways: the urea cycle-nitric oxide pathway and the glutathione pathway. the investigators hypothesize that prematurity-related limitations in the function of these important biochemical pathways contribute to respiratory disease risk over the first year of life.

the primary goal of the improv/prop study is to identify biomarkers (biochemical, physiological and genetic) and clinical variables that are associated with and thus potentially predictive of pulmonary status in preterm infants at 1 year corrected age. improv will test the hypothesis that biochemical immaturity and functional genetic variation in the urea cycle-nitric oxide (uc-no) and glutathione (gsh) pathways influence the development and severity of bronchopulmonary dysplasia (bpd), a form of chronic lung disease that affects more than 10,000 premature infants each year in the us. improv will also test the hypothesis that the duration and degree of no insufficiency and free radical excess predicts bpd severity and correlates with persistence of lung problems after nicu discharge. our hypothesis implicates (a) an immature liver and gastrointestinal ability to make citrulline and gsh, (b) inadequacy of nutritional amino acid substrate and (c) common genetic variations in the uc-no and the gsh pathways in the pathogenesis of bpd. these factors limit the ability of the anatomically and functionally immature lung to respond to the physiologic and environmental stress of preterm birth. as part of the prop multi-center study, novel approaches to characterizing lung status with non-invasive respiratory measures prior to nicu discharge will be employed. a composite primary outcome of morbidity that is based on serial parental reports of respiratory symptoms, medications, hospitalizations and dependence on technology during the first year of life has been developed.

Eligibility criteria:
inclusion criteria: * infants who are less than or equal to 7 days old; * gestational age (ga) between 23 weeks and 0/7 days and 28 weeks and 6/7 days exclusion criteria: * the infant is not considered to be viable (decision made not to provide life-saving therapies); * congenital heart disease (not including pda and hemodynamically insignificant vsd or asd); * structural abnormalities of the upper airway, lungs or chest wall; * other congenital malformations or syndromes that adversely affect life expectancy or cardio-pulmonary development; * family is unlikely to be available for long-term follow-up.

Keywords: prematurity respiratory disease bronchopulmonary dysplasia
emergency home delivery. learning skills for medical doctors and nurses. kirkpatrick levels of learning

Conditions: Home Birth Delivery

Summary: mannequin training for emergency home delivery on medical doctors and nurses

two groups will be exposed to frontal lecture and simulato scenario on emergency home birth. after the first training a debriefing will be done. following a second scenario will bi performed. all participants will complete a google form questionnaire before and after addressed to understand the value of their participation.

Eligibility criteria:
inclusion criteria: * medical doctors and nurses exclusion criteria: * none

Keywords: home birth emergency skills
jaundice as initial presentation of liver hydatidosis (ictehida)

Conditions: Hepatic Echinococcosis; Jaundice

Summary: the aim of this study is to evaluate patients with hepatic hydatidosis whose symptom at diagnosis was obstructive jaundice. as well as analyzing, the rate of performing preoperative ercp, the results after surgery and morbidity

retrospective study of patients operated on for liver hydatidosis and whose initial symptom was obstructive jaundice study period: january 2006 to september 2018 the preoperative diagnosis was based on abdominal ultrasound (us), ct scan or magnetic nuclear resonance surgical technique precautions are taken to avoid the spillage of the parasite in the abdominal cavity. the peritoneal cavity is liberally protected with scolicidal agents. all patients have intraoperative ultrasound. ultrasound is performed to locate the presence of any cysts which might not be seen by the preoperative imaging. intraoperative ultrasound is also used to find out the relation of the cyst to the big vessels. depending on the intraoperative findings, the location and size of the cyst will be considered the type of surgery to be performed. radical surgery (closed and open total cystopericystectomy, or liver resection) or conservative surgery (partial cystopericystectomy, removal of the vesicles with external or internal drainage). when the cyst affects a total lobe and / or the main pedicles, a hepatectomy is performed. the demographic data of the patients will be taken from their clinical histories. it included age, sex, medical history of hidatidosis, clinical findings, laboratory data, radiological findings, endoscopic treatment, surgical treatment. the investigators will analyze postoperative mortality and morbidity. complications' ranking according to the clavien-dindo score, 'severe complication' is defined as greater or equal to iiia follow-up the follow-up of these patients will be performed with ultrasound or ct and hydatid serology. the minimum follow-up of the patients is six months. relapse is defined as the appearance of new active liver cysts after the patient had undergone surgery.

Eligibility criteria:
inclusion criteria: * hepatic hydatidosis with obstructive jaundice surgically treated exclusion criteria: * patients with conservative treatment

Keywords: jaundice echinococcosis liver surgical treatment
breath regulation and yogic exercise an online therapy for calm and happiness during the covid-19 pandemic

Conditions: Job Stress; Workplace Stress; Compassion Fatigue; Psychological Trauma; Healthcare Workers; Healthcare Providers

Summary: this study will examine the feasibility of conducting an online randomized controlled trial (rct) in frontline hospital and long term care healthcare staff in managing covid-19 patients in london, on. the study will randomize participants to sudarshan kriya yoga (sky) or a health enhancement program (hep).

the covid-19 pandemic continues to escalate as a global health threat, leading to devastating impacts on the healthcare system. frontline healthcare workers are dealing with increased demands and fears for their own, as well as their family's safety. adding to the stress is the limited ability to maintain social connectedness as physical distancing measures are in place. the investigators plan to conduct an open-label feasibility randomized controlled trial (rct), comparing an online breath based yogic intervention called sudarshan kriya yoga (sky) (n=30) versus an online control mind-body intervention called the health enhancement program (hep) (n=30) in 60 hospital and long term care frontline staff that are managing covid-19 patients. participants will be blinded to the treatment hypothesis while data analyst will be blinded to treatment allocation. both sky and hep will be taught online in two phases in the first week followed by weekly reinforcement sessions for the following 4 weeks. feasibility measures will be assessed as well as self-rated measures of insomnia, anxiety, depression, and resilience. the investigators expect that it will be feasible to conduct an online rct of two mind-body interventions, sky and hep, in staff managing the covid-19 pandemic, and that the investigators will be able to remotely monitor safety and efficacy of these interventions.

Eligibility criteria:
inclusion criteria: 1. participants will be frontline hospital or long-term care home staff involved in the management of covid-19 patients in canada or the united states of america. 2. participants will be aged 18 to 70. 3. participants will be willing and able to attend, via webex software, the introductory phase of sky or hep, as well as at least two of the four weekly follow-up sessions 4. have sufficient hearing to follow verbal instructions. 5. have an adequate understanding of english. 6. able to sit without physical discomfort for 60 minutes. 7. not pregnant and willing to remain not pregnant for the duration of the study. exclusion criteria: 1. inability to independently provide informed consent. 2. current suicidality as assessed by the suicide item of the patient health questionnaire-9 scale. 3. history of bipolar disorder. 4. history of chronic ptsd. 5. history of schizophrenia or schizoaffective disorder. 6. currently practice any type of formal meditation, mindfulness, or breathing techniques regularly (greater than 3 times per week). 7. history of complex ptsd.

Keywords: covid-19 coronavirus healthcare staff work stress insomnia anxiety depression resilience mind-body intervention
exercise-induced in secondary mitral regurgitation: analysis of echocardiographic parameters at rest predicting the onset of significant exercise-induced mitral regurgitation

Conditions: Cardiac Disease

Summary: secondary mitral insufficiency is a common complication of heart failure, aggravating symptoms and prognosis, and may be responsible for worsening dyspnea, pulmonary edema, and excess mortality. it is essentially a ventricular rather than a valvular disease, whose origin may be ischemic or not. it is induced by a geometrical and contractile modification of the left ventricle which causes an imbalance between the tensile and the closing forces of the mitral valve thus causing a defect of coaptation and the increase of the surface between the mitral leaves and the ring in systole (tenting). dynamic mitral insufficiency is defined by changes in the degree of severity of regurgitation as a function of hemodynamic conditions. during exercise, the course of mitral insufficiency is variable and is not predicted by the degree of regurgitation at rest. the worsening of the leak is also well correlated with the onset of dyspnea on exertion in patients with left ventricular ejection fraction heart failure (lvef reduced). nevertheless, there is little data available in the literature on the factors predisposing to the development of stress-related mitral insufficiency, as well as its clinical and echocardiographic impact in the cardiac insufficiency patient, particularly in the case of preserved lvef (6.7%). the identification of echocardiographic data at rest to predict and anticipate the behavior of mitral insufficiency in the effort (aggravation or stability / disappearance), would allow a simplified evaluation and a better management in this population of patients for which the evaluation in echography of effort can be technically complex and limited (difficulty of quantification of the mitral leak, time of effort sometimes too short ...).


Eligibility criteria:
inclusion criteria: * patient whose age is ≥ 18 years * patient who received a stress echocardiography performed by an experienced operator in the evaluation of mitral insufficiency at the paris saint-joseph hospital group between march 2016 and february 2019 * patient presenting during this ultrasound a mitral insufficiency secondary to rest and effort * francophone patient exclusion criteria: * patients under guardianship or curatorship * patients deprived of their liberty * patients who oppose the use of their data for this research * patient with primary mitral insufficiency, structural abnormality of valvular leaflets * patient with valvular or valvular calcification * patient with other significant associated valvulopathy (grade\> ii / iv: corresponds to the severity of mitral leak quantified on cardiac ultrasound) * patient with cardiac valve prosthesis * hypertrophic or restrictive cardiomyopathy * patient with congenital heart disease