Kornimate/medical-research-clean huggingface dataset:
improvement of facial recognition ability and multitasking

Conditions: Facial Discrimination; Multitasking

Summary: this study aims to determine the efficacy of training on facial recognition and multitasking. the researchers hypothesize that participants who have undergone facial recognition and multitasking training will demonstrate an improved facial recognition ability and performance in multi-tasking. the researchers also hypothesize that measures of sustained and selective attention will predict performance on multitasking tasks. this work sets the ground work for future research into if and how facial recognition and multitasking ability can be improved.

there has been evidence showing improvements on performance on various cognitive tasks after training, but evidence on multitasking and facial recognition is lacking. both multi-tasking and facial recognition are crucial for military and law enforcement personnel, and the respective organizations can consider these abilities during their respective recruitment and training processes. this study will test whether training on multi-tasking and facial recognition tasks can improve an individual's performance. additionally, it will test whether their performance on other measures of attention and multitasking can predict changes post-training. participants will go through 5 testing sessions span over 5 days. for each session, participants will complete a multitasking task and a facial recognition task. participants are hypothesized to improve in their performance after 5 consecutive days of training on these 2 tasks. additionally, participants will also complete 2 attention tasks, 1 face memory task, and 1 other multi-tasking task only on the first day. both multitasking tasks are expected to correlate at baseline, and performance on the attention tasks may predict performance on multitasking tasks as these tasks require sustained and selective attention. a face memory task will also be used to account for each individual's baseline facial recognition ability.

Eligibility criteria:
inclusion criteria: * participants must be over 21 if they are not from nus or yale-nus. nus or yale-nus students over 18 can also participate. all participants are expected to be fluent in english. exclusion criteria: * participants with a history of perceptual or memory deficit will be excluded.
prospective randomized study to compare results of pelvic organ prolapse repair with one versus two vaginal meshes

Conditions: Pelvic Organ Prolapse

Summary: the purpose of this study is to compare anatomical differences, quality of life and sexual function and complications rate between apical support with one anterior vaginal mesh versus repair with two separate meshes.

in the presence of stage 3 anterior wall prolapse (cystocele) with second stage apical prolapse (uterine or vault prolapse) there are 2 optional ways to repair with vaginal mesh: (a) to use 2 separated meshes: anterior mesh to correct the anterior compartment and posterior mesh to correct the apical prolapse to the sacrospinous ligament (ssl). (b) to correct both anterior compartment and the apical prolapse with the same mesh while using the posterior arms of the mesh to fix the apical prolapse to the ssl. each way has its advantages and disadvantages. the first way was described at the beginning of mesh use and might be more anatomical then the second newest way. the addition of apical support to the anterior mesh might theoretically shorten the vagina. there are several recent studies describing the anatomical outcomes both for anterior compartment and apical compartment with a single mesh. mesh-related complications, which can be also related to the amount of vaginal meshes, can potentially decrease with one mesh as compare with 2 meshes. the aim of the study: if the anatomical results, vaginal length and quality of life, will be with no significant differences between the two groups, the investigators will recommend to use a single mesh, in order to avoid / minimize potential complications of vaginal mesh. if there will be no differences in complications in both groups but will be a significant difference in vaginal length and sexual function, the investigators will recommend using two meshes.

Eligibility criteria:
inclusion criteria: * at least anterior compartment prolapse stage iii and uterine prolapse stage ii. exclusion criteria: * women without uterine prolapse, or with uterine prolapse \< stage 2. * women with uterine prolapse \> stage 2. * hysterectomy in the past. * women with an indication for hysterectomy.

Keywords: vaginal mesh total vaginal length quality of life
effect of craniocervical neural mobilization on quality of life in patients with primary tension headache

Conditions: Tension-Type Headache

Summary: this study will be conducted to investigate the effect of craniocervical neural mobilization on quality of life in patients with primary tension headache.

the world health organization estimates that the three most prevalent neurologic disorders worldwide are tension-type headache (1.5 billion), migraine (958.8 million), and medication overuse headache (58.5 million). collectively, these three disorders contribute approximately 17% to the global burden of neurologic diseases, with migraine the second most disabling disease overall. tth (tension type of headache) is defined as mild to moderate band-like pressure headache with few associated symptoms. it varies considerably in frequency and duration, from rare, short-lasting episodes of discomfort to frequent, long-lasting, or even continuous disabling headaches.physiotherapy treatment based on manual therapy achieved positive outcomes in pain intensity and frequency, disability, impact of headache, quality of life, and craniocervical range of motion in adults with tth. although pervious findings showed a clinical improvement, there is no clear evidence that one technique is superior to another.neurodynamic techniques can improve mechanical functions in nerve structures, such as tension and sliding functions. when the nerve structure experiences clamping and disrupts mobility, pain occurs along the nerve. neurodynamic sliding techniques play a major role in improving blood circulation and axonal transport, as well as increasing nerve integrity and reducing the pressure caused by intraneural and extraneural fibrosis. thirty patients with tension headache will be allocated randomly into two equal groups. the first one will receive craniocervical mobilization and a selected physiotherapy program and the control group will receive selected physiotherapy program for one month.

Eligibility criteria:
inclusion criteria: * the type of headache will be primary tension type of headache. * age of subjects will range from 25-40 years. * the duration of headaches swill be one years ago. * body mass index from 25 to less than 30. exclusion criteria: * major neurological conditions (e.g. stroke, multiple sclerosis, epilepsy, brain tumor, meningitis, and hypertension). * patients with cervical spinal cord injury, recent trauma of head. * patients with auditory and visual impairments. * smoker and addicted subjects.

Keywords: craniocervical neural mobilization quality of life primary tension headache
volumetric analysis of resorption types on cbct

Conditions: Endodontic Disease; Tooth Resorption

Summary: more accurate management of resorption can be achieved thanks to the three-dimensions volumetric and linear analysis, and the axial classification presented in this study.

the aim of this study was to investigate the volumetric and linear analysis, and to present the axial classification of root resorptions using cone beam computed tomography (cbct). a total of 43 teeth of external cervical resorption (ecr) (n=27), external replacement resorption (err) (n=4) and internal root resorption (irr) (n=12) were identified from 34 patients. the volume of resorption and total tooth, the widest lengths of these resorptions, and the amount of thinnest dentin thickness around them were measured and compared according to age and sex. additionally, the eight regional axial classification was performed and the percentages in these regions were evaluated. significance was set at p=0.05 for statistical analysis. more accurate management of resorption can be achieved thanks to the three-dimensions volumetric and linear analysis, and the axial classification presented in this study.

Eligibility criteria:
inclusion criteria: * cases of resorption that had cbct images exclusion criteria: * those presenting pathologic lesions, congenital/developmental anomalies or teeth with root canal filling * those whose cbct scans failed to present satisfactory quality. * additionally, sr, tap, and eir cases were excluded because their true dimensions could not be completely determined before resorption.

Keywords: cone beam computed tomography endodontics tooth resorption
long-term outcome of ripc after iv thrombolysis in ais patients

Conditions: Acute Ischemic Stroke

Summary: the goal of this observational study is to learn about the long-term efficacy of our previous study in acute ischemic stroke(ais) patients who underwent either remote ischemic postconditioning(ripc) or sham treatment after intravenous thrombolysis. the main questions it aims to answer are: * dose the ripc treatment combined with iv thrombolysis can improve the long-term functional outcome in ais patients? * dose the ripc treatment combined with iv thrombolysis can improve the incidence rates of all-cause and cardiovascular mortality, recurrent stroke/tia, new-onset clinical af on this long-term follow-up? a single rater (a.e.p.) trained by an experienced stroke physician (s.t.e.) contacted patients, relatives, and family physicians to gather all available medical information on the following issues: 1) survival status, 2) date of death in those who died (based on information of the treating physicians), 3) mrs score at the time of the interview, 4) recurrent stroke/tia, 5) new onset atrial fibrillation, 6) other cardiovascular events, including myocardial infarction, pulmonary embolism, deep venous thrombosis, peripheral arteriopathy. researchers will compare ripc group and control group to see if the ripc treatment have a long-term effect in ais patients.


Eligibility criteria:
inclusion criteria: * all patients who completed the previous interventional rater-blinded controlled study were invited for the follow-up session.
study of low bone mass in premenopausal or perimenopausal women

Conditions: Osteoporosis

Summary: objectives: i. determine the possible causes of bone loss in premenopausal or perimenopausal women.

protocol outline: patients undergo physical examination and complete history with emphasis on risk factors for osteoporosis and screening for occult secondary causes of osteoporosis through blood serum and 24 hour urine collection. patients with more than 6 months since prior bone mineral density measurements or who did not receive measurements at participating center, undergo dual energy x-ray absorptiometry over 30 minutes for bone mineral density measurements.

Eligibility criteria:
protocol entry criteria: --disease characteristics-- * low bone mass (t score less than -2.0) with no secondary cause on routine exam * premenopausal or * perimenopausal --prior/concurrent therapy-- * chemotherapy: no prior or concurrent chemotherapeutic agents * endocrine therapy: no prior or concurrent glucocorticoids or suppressive doses of thyroid hormone * other: no prior or concurrent anticonvulsants --patient characteristics-- * hematopoietic: no multiple myeloma * other: no hyperparathyroidism no thyrotoxicosis no anorexia nervosa no paget's disease of bone no rheumatoid arthritis no cushing's syndrome no malabsorption syndrome no type i diabetes mellitus

Keywords: disease-related problem/condition osteoporosis rare disease
can robot-assisted gait training in addition to conventional rehabilitation provide better outcomes in children with cerebral palsy?

Conditions: Cerebral Palsy; Robotics

Summary: a total of 26 patients who were diagnosed with cp \[diplegic, with gross motor function classification system (gmfcs) level of 2-5\] and who regularly participated in a rehabilitation programme were included in the study after obtaining approval from their parents. the patients were randomly assigned to two groups. group 1 (n = 13) received conventional therapy (65 min, 2 days/week ×8) and group 2 (n = 13) received 25 minutes of robot-assisted gait training (robogait®) in addition to conventional therapy (40 min, 2 days/week ×8).

purpose: this study aimed to investigate the effects of robot-assisted training (rat) on motor functions, spasticity status, balance and functionality in children with cerebral palsy (cp). method: a total of 26 patients who were diagnosed with cp \[diplegic, with gross motor function classification system (gmfcs) level of 2-5\] and who regularly participated in a rehabilitation programme were included in the study after obtaining approval from their parents. the patients were randomly assigned to two groups. group 1 (n = 13) received conventional therapy (65 min, 2 days/week ×8) and group 2 (n = 13) received 25 minutes of robot-assisted gait training (robogait®) in addition to conventional therapy (40 min, 2 days/week ×8). outcome measures: gmfcs was used to evaluate motor functions and modified ashworth scale was used to evaluate spasticity. paediatric berg balance scale, paediatric functional independence measure and timed up and go test were used to assess balance and functional status. the evaluations were performed at baseline and after 8 weeks of therapy.

Eligibility criteria:
inclusion criteria: * diplegic cp and who were level 2-5 according to the gross motor function classification system (gmfcs) were included in the study. children who presented with any disorder involving the peripheral nervous system or another neurological disorder such as epilepsy were not included. exclusion criteria: * patients in whom the dose of their prescribed medication for spasticity was changed during the study period were excluded

Keywords: cerebral palsy robotics functional status
foot reflexology on premenstrual syndrome

Conditions: Reflexology; Dietary Modification

Summary: : premenstrual syndrome (pms) is a set of physical, emotional and behavioral symptom that start during the week preceding menstruation and are alleviated when the menstrual flow begins. reflexology is one of the most popular complementary therapies

this study was aimed to determine the effect of foot reflexology in the treatment of premenstrual syndrome. subjects and methods: fifty volunteer, single females with premenstrual syndrome (pms) were selected randomly from outpatient clinic of obstetrics and gynecology at kasr el ainy university hospital, faculty of medicine, cairo university to share in this study, their age ranged from 18 to 25 years old and their body mass index (bmi) did not exceed 30kg/m2, the participants were assigned into two groups of equal numbers. the group (a) received therapeutic foot reflexology with dietary modification 3 times/week for8 weeks, while the group (b) received dietary modifications only for 8 weeks. all subjects in both groups were assessed through the visual analogue scale (vas) for pain and premenstrual daily symptoms questionnaire for (pms) related symptoms. results: the results of the present study revealed that there was statistically significant improvement in both pain and premenstrual related symptoms in group (a) than in group (b).

Eligibility criteria:
inclusion criteria: * their age ranged from 18 to 25 years old * their body mass index (bmi) did not exceed 30kg/m2 exclusion criteria: * rheumatoid arthritis * bronchial asthma * depression * anxiety
diabetes and palliative care

Conditions: End-of-life; Diabetes; Terminal Cancer

Summary: diabetes prevalence in palliative care is 10-15%. most hospice patients are treated with insulin. the target glucose level is high in order to decrease the risk of hypoglycemia. glucose level is usually monitored using capillary blood glucose once to three times daily. the aim of the research is to simplify this pattern of care in end-of-life patients. it will evaluate whether the non invasive measurement of glucose in urine could replace the measurement of capillary blood glucose. the first objective will be to assess the performance of the measurement of glucosuria using urinary dip stix to predict that the blood glucose level is within the target range. due to the high glucose target, hyperglycemia is extremely frequent. however, symptoms of hyperglycemia are unfrequently reported. they may be unspecific and/or masked in end-of-life patients due to terminal disease and medication. the second objective of the study will be to define symptoms of hyperglycemia in these patients.

this is a prospective study involving several palliative care units in france. glycemia and glycosuria will be measured in the same patients. symptoms that could be related to hyperglycemia will be assessed in relation with the concomitant blood glucose level. main investigations : glycosuria and cetonuria will be measured using a dip stix during each nursing care. glycemia will be measured before breakfast and before diner. pain caused by finger pricking for the measurement of glycemia will be evaluated using a verbal scale. symptoms will be evaluated at the time of each glucose measurement first with open questions then with a list of potential symptoms of hyperglycemia.

Eligibility criteria:
inclusion criteria: * diabetic patients * hospitalised in a palliative care unit * terminally ill with cancer * with blood glucose measurement at least twice daily over 5 days * agreeing to participate in the study exclusion criteria: * patient unable to communicate, to understand information about the study or to decline participation in the study
vitamin b6 on relieving linezolid-associated cytopenias

Conditions: Cytopenias; Erythropenia (Diagnosis)

Summary: linezolid is the first approved synthetic oxazolidinone that is active against multidrug-resistant gram-positive pathogens. because of its significant efficacy, linezolid is widely used in clinical treatment. however, the side effects of linezolid commonly lead to anemia and thrombocytopenia. this hematological toxic effects limit its prolonged used. the investigators have found that vitamin b6 application, as a preventive, auxiliary therapy, can relieve anemia and thrombocytopenia. the present study was designed to verify the effects of vitamin b6 in the prevention of linezolid-associated cytopenias and investigate its mechanism.

infected patients receiving linezolid therapy are divided into two groups, i.e. the linezolid group and the linezolid + vitamin b6 group, the line of division being whether vitamin b6 is to be applied or not in the course of treatment. the purpose is to evaluate the role that vitamin b6 plays, during the process of linezolid therapy, in the relief of erythropenia and cytopenias.

Eligibility criteria:
inclusion criteria: * use of linezolid is not less than 3 days exclusion criteria: * serious adverse reactions

Keywords: linezolid vitamin b6 linezolid-associated cytopenias
representation of the bladder innervation using diffusion tensor imaging fiber tracking with mri - a pilot study

Conditions: Spinal Cord Injury; Neurogenic Lower Urinary Tract Dysfunction

Summary: the exact innervation of the bladder and the changes after a spinal cord injury have been not yet been illustrated. diffusion tensor imaging with magnetic resonance imaging is a new technique which can be used to visualize single nerve fibers, and thus represent the neural supply of a region in vivo. there are studies in which both the sacral plexus and the lumbar nerve roots have been represented using diffusion tensor imaging. however, there is no study concerning the innervation of the bladder. the investigators are therefore using diffusion tensor imaging with magnetic resonance imaging to represent the bladder innervation of individuals with neurogenic lower urinary tract dysfunction and individuals with normal bladder function.


Eligibility criteria:
inclusion criteria: * neurogenic lower urinary trat dysfunction * normal bladder function exclusion criteria: * no signed informed consent * contraindications for mri (pace maker, implanted metal, claustrophobia) * upper or lower urinary tract surgeries * pregnancy (anamnestic)

Keywords: diffusion tensor imaging fiber tracking magnetic resonance imaging spinal cord injury neurogenic lower urinary tract dysfunction
the performance of the soltive laser system for laser lithotripsy in kidney or ureteral stones

Conditions: Kidney Stone; Ureteral Stone

Summary: the purpose of this study is to collect real-world evidence on the performance of the soltive™ premium superpulsed laser system for laser lithotripsy in ureteroscopy, percutaneous nephrolithotomy (pcnl) and mini pcnl for kidney and ureteral stones.


Eligibility criteria:
inclusion criteria: 1. ≥18 years of age 2. medical indication for ureteroscopy, percutaneous nephrolithotomy (pcnl) or mini pcnl 3. willing and able to provide informed consent 4. female and of childbearing age with a negative pregnancy test exclusion criteria: 1. contraindicated for uteroscopy, pcnl or mini pcnl as determined by the physician 2. inability to tolerate anesthesia for any reason 3. unable or unwilling to provide informed consent 4. concurrently participating in another competing clinical study 5. known ureteral stricture 6. unwilling or unable to return for follow-up
electroconvulsive therapy in clozapine-resistant schizophrenia

Conditions: Schizophrenia; Schizoaffective Disorder

Summary: electroconvulsive therapy (ect) is one of the oldest neuromodulation treatments still used in psychiatry. only case reports and open label non-randomized studies have been published of ect in clozapine-resistant schizophrenia patients. the purpose of this trial is to study the efficacy and cognitive effects of add-on ect treatment (10-course) in schizophrenia patients taking clozapine.


Eligibility criteria:
inclusion criteria: * diagnosis of schizophrenia or schizoaffective disorder * treatment-resistant to clozapine * age 18 - 64 years * capacity and willingness to give informed consent exclusion criteria: * serious somatic illness * progressive neurological illness, recent brain damage or sequela of serious brain damage * ect less than 3 months prior to this trial

Keywords: clozapine ect panss schizoaffective disorder schizophrenia treatment
lyspro insulin vs regular insulin in cirrhotic patients

Conditions: Diabetes Mellitus; Cirrhosis

Summary: objective: to compare lispro insulin and regular insulin in the glycemic control of patients with liver cirrhosis and type 2 diabetes subjects. methods: 108 patients with liver cirrhosis and type 2 diabetes were randomly treated with regular insulin or lispro. after 122 weeks a cross-over was carried out and patients followed-up for 122 weeks. then, all patients received a standard breakfast of 145 kcal following 12 u.i. of regular insulin or lispro, and c-peptide and insulin serum levels were determined over 300 minutes.


Eligibility criteria:
inclusion criteria: * insulin-treated diabetes mellitus and liver cirrhosis exclusion criteria: * oral hypoglycemic agents treated diabetes mellitus * liver cancer

Keywords: lyspro regular insulin cirrhotic patients