Kornimate/medical-research-clean huggingface dataset:
a reliability and validity study of the urdu version of spine functional index.

Conditions: Spinal Deformity

Summary: the aim of the study is to translate spine functional index scale into urdu language and to investigate the validity and reliability in pakistan with the populace of spinal disorders. also checks its co-relation with neck disability index and roland-morris disability questionnaire.

as per the previous recommendations, the spine functional index will be interpreted in urdu language and adapted culturally. participants will be selected by the convenience sampling technique based on pre-defined inclusion and exclusion criteria from a total of 220 participants with spinal disorders. to test the reliability of urdu version of spine functional index, neck disability index and roland-morris disability questionnaire in the inter and intra-observer environment, two observers and an interim interval of 45 minutes between the first and second application fill out a questionnaire on the same day for the inter-observer assessment. observer-1 for the intra-observer evaluation will conduct a third evaluation after 7 days. using statistical package of social sciences version 24, data is entered and analyzed. cronbach alpha value is used to analyze center consistency. the intraclass correlation coefficient is used to assess the reliability of the test-retest. for content validity, criteria validity and responsiveness, the urdu version of spine functional index was assessed.

Eligibility criteria:
inclusion criteria: * the criteria for participation in this study were at least 18 years of age. * the patient must be diagnosed with musculoskeletal disorder of the spine. * the patient can be chronic and sub-acute and acute. * the patient can be referred by a physician or physical therapist. exclusion criteria: * lack of reading urdu or reply to the survey questions were the criteria for exclusion. * infectious diseases and patient without spinal disorders were excluded. * the patients with late surgery or systemic sickness which effects spine was excluded

Keywords: spine functional index spinal disorders cultural adaptation validity urdu version reliability
treatment of tibial plateau fractures with bone-graft and bone tamp technique

Conditions: Depressed Tibial Plateau Fractures

Summary: autologous icbg and bone tamp methods are often applied to manage depressed tibial plateau fracture (dtpf), but previous iliac bone harvesting and bone tamp techniques remain controversial. the purpose of this study is to describe and evaluate the technique of using structural bicortical autologous iliac crest bone-graft (icbg) combined with tunnel bone tamps method (tbtm) in treating dtpfs.


Eligibility criteria:
inclusion criteria: * adult patients (age ≥ 18 years); * diagnosis of dtpfs; * agreeing to receive structural bicortical autologous icbg combined with tbtm treatment and subsequent internal fixation treatment; * agreeing to participate in regular follow-up after surgery. exclusion criteria: * open fracture; * pathologic fractures; * bone metabolic disease; * previous icbg; * infection or soft tissue injury of the iliac bone donor site; * pelvic fractures or bone tumors; * associated peripheral nerve injury; * non-completion of 30 months follow-up.
prp therapy to m. gluteus medius during tha

Conditions: Hip Osteoarthritis

Summary: study purpose is to evaluate perioperative usefulness of platelet-rich plasma (prp) in total hip arthroplasty (tha) surgery. the study is designed as a randomized double blinded study using saline as placebo. the measurement outcomes includes objective variables (mri, dynamometer) as well as subjective measurements (oxford hip score, harris hip score). patients are assigned to two different groups, according to a randomization list. prp (approximately 9ml from which 1ml is delivered to in-house laboratory for the measurement of platelet count) is obtained from venous blood and applied to m. gluteus medius during the closure of modified lateral approach (hardinge). study participants are evaluated preoperatively by trained physiotherapist. after surgery, participants undergo clinical evaluation and imaged (mri) at 3 and 12 months post-operative. in the same time points, strength, harris hip score and oxford hip score. at the end of the study, the nature of the injected substance is revealed to the patients.


Eligibility criteria:
inclusion criteria: * clinically and radiology confirmed arthritis which treatment is total hip arthroplasty. exclusion criteria: * revision surgery, insulin dependent diabetes and other endocrinology disease, smoking, use of per os cortisone, malignancy, rheumatoid arthritis, any autoimmune disease, alcoholist, previous fracture to hip, patients with diagnosed mental illness, absolute contraindications for mri study
tickle stimulation in disorders of consciousness (doc)

Conditions: Disorders of Consciousness

Summary: the aim of this project is to investigate whether tickling stimulations can have a short-term effect on the responsiveness of patients with disorders of consciousness due to severe acquired brain injury and to compare this effect with that of neutral tactile stimulations that do not induce tickling.

during the experimental session, patients will undergo the crs-r and the nociception coma scale-revised (ncs-r) to ensure that any responses to tickling are not influenced by pain sensations. subsequently, fnirs detection optodes will be placed using a non-invasive frontal headband. a 10-minute resting-state recording will be performed. next, patients will be subjected to tickling: they will be tickled bilaterally in the three most ticklish areas identified in a pilot study with healthy subjects-namely, the soles of the feet, the armpits, and the ribs-plus a control area, the forehead. the stimulation will be manual and will be performed by rubbing the targeted body part while opening and closing fingers in pairs in an arched motion. additionally, patients will also receive a neutral stimulation (in the same body areas), which consists of simply touching the area without inducing tickling. the order of stimulations will follow a randomized list. each stimulation will last for 5 seconds, followed by 5 seconds of rest, repeated twice. in total, patients will be stimulated for 10 seconds plus 5 seconds of rest (15 seconds in total) for each body area. there will be a 1-minute pause between each area. afterward, an additional 10 minute resting-state fnirs recording will be conducted. during the experimental session, patients will be filmed so that the videos can be analyzed by two different experimenters, who will assess differences between stimulations based on facial expressions, verbalizations/vocalizations, body movements, and changes in emotional state (e.g., crying, smiling, grimacing). at the end of the protocol, the fnirs optodes will be removed. in total, the experiment will last approximately one hour and fifteen minutes: 30 minutes for crs-r/ncs-r and 45 minutes for the tickling protocol and fnirs recording.

Eligibility criteria:
inclusion criteria: * diagnosis of disorders of consciousness (doc) based on the crs-r scale; * age ≥18 years; * time since the event ≥ 28 days exclusion criteria: * large craniectomy that may interfere with fnirs recording; unstable clinical conditions (e.g., respiratory failure, fever, status epilepticus, etc.); * fractures, paralysis, injuries, or muscular dystrophy that prevent proper stimulation of the aforementioned body parts; * lack of informed consent from the legal representative.

Keywords: tickle stimulation behavioural evaluation neurophysiological evaluation disorders of consciousness
study evaluating the safety and efficacy of ir2 in untreated and unfit elderly patients with dlbcl

Conditions: Diffuse Large B Cell Lymphoma

Summary: this is a single-arm, open-label phase 2 study of ir2 in the treatment of unfit and elderly patients with untreated diffuse large b-cell lymphoma。

this open-label, single arm study will evaluate the efficacy and safety of ibrutinib， lenalidomide, rituximab (ir2) in previously untreated and unfit elderly subjects with diffuse large b-cell lymphoma. subjects will receive 6 cycles of ibrutinib 560mg, day 1-21, orally (po) , lenalidomide 25mg, day 1-10, rituximab 375mg/m2, intravenously, every 21 days.

Eligibility criteria:
inclusion criteria: 1. pathologically confirmed diffuse large b cell lymphoma, treatment naive 2. age \> 75 years 3. ineligible for standard chemotherapy 4. must has measurable lesion in ct or pet-ct prior to treatment 5. at least 3 months life expectation 6. informed consented 7. no previous use of study drug exclusion criteria: 1. has accepted chemotherapy before 2. uncontrollable cardio-cerebral vascular, coagulative, autoimmune, serious infectious disease 3. lab at enrollment (unless caused by lymphoma): neutrophile\ 2\*uln; akp or bilirubin \>1.5\*uln ;creatinine\>1.5\*uln 4. not able to comply to the protocol for mental or other unknown reasons pregnant or lactation 5. hiv infection 6. if hbsag positive, should check hbv dna, dna positive patients cannot be enrolled. if hbsag negative but hbcab positive (whatever hbsab status), should check hbv dna,dna positive patients cannot be enrolled. 7. other uncontrollable medical condition that may that may interfere the participation of the study

Keywords: ir2
effects of active and prt on pain, function and temporospatial gait parameters in runners with plantar fascitis

Conditions: Gait; Pain; Plantar Fascitis

Summary: the study is randomized and single -blinded. ethical approval is taken from ethical committee of riphah international university lahore.participants who will meet criteria will be requested to give verbal consent and to sign written consent form. after signing consent form participants will be allocated to the group a and group b by using computerized generated randomization. group a will receive ultrasound then active release technique while group b will receive ultrasound and positional release technique for 4 weeks. treatment sessions will be 12 sessions, 3 sessions per week on alternative days for 4 weeks

a single blinded randomized clinical trial will be conducted on 26 subjects diagnosed for planter fasciitis from jawad club faisalabad and alfatah sports club, faisalabad by looking for symptoms and tenderness at heel as mentioned in inclusion criteria and will confirmed by windlass test. participants who will meet criteria will be requested to give verbal consent and to sign written consent form. after signing consent form participants will be allocated to the group a and group b by using computerized generated randomization. group a will receive ultrasound then active release technique while group b will receive ultrasound and positional release technique for 4 weeks. treatment sessions will be 12 sessions, 3 sessions per week on alternative days for 4 weeks. pain will be measured by numerical pain rating scale (nprs), foot and ankle disability will be assessed by foot function index (ffi), while gait parameters i.e. walking speed will be measured by 4-meter walking test, and step and stride length will be evaluated by measuring tape by taking foot prints before and after the 4 weeks of treatment period. data will be analyzed through statistical package for the social sciences (spss) version 22.

Eligibility criteria:
inclusion criteria: * male runners age between 18-30 years * duration of running at least 6 months * positive windlass test * patients with unilateral or bilateral plantar fasciitis exclusion criteria: * recent accidental foot or ankle injury * previous lower-body surgical intervention within 6 months * recent fractures in the lower limb (femur, tibia, fibula or foot bones) within 6 months * diagnosed musculoskeletal disorders (rheumatoid arthritis, calcaneal spurs) * diagnosed neuropathy, local and systemic neurologic disorders (including sciatica, tarsal tunnel syndrome, nerve entrapment of abductor digiti minimi and posterior tibial

Keywords: pain functions
huntington's disease biobank: advancing remote monitoring and deep phenotyping

Conditions: Huntington Disease

Summary: this observational study aims to identify novel biomarkers of disease onset and progression in huntington's disease by integrating remote monitoring with fluid biomarkers. using video-based computer vision and mobile app-based cognitive assessments combined with machine learning algorithms, we aim to develop markers that can be used by huntington's disease patients at home. using machine learning to analyze videos of movement will capture the movements with an accuracy that will be as good as seeing an expert neurologist. these individualized markers can be followed over time to evaluate symptoms onset and change. the study will track disease progression and correlate these digital markers with changes in plasma and cerebrospinal fluid. the ultimate goal is to advance biomarker discovery and therapeutic development for huntington's disease. the study includes one in-person visit per year. a remote visit via zoom or facetime (15 min) every three months to record videos of movement. we can also share cutting-edge wristbands and a mobile phone app.


Eligibility criteria:
inclusion criteria: * individuals with a positive test for the hd expansion mutation. exclusion criteria: * individuals with movement disorders with a negative test for the hd expansion mutation.

Keywords: huntington's disease biomarkers remote monitoring biobank observational study
influence of surgical regional anesthesia on postoperative pain

Conditions: Elective Cesarean Section

Summary: to compare three types of anesthetic techniques (spinal anesthesia, combined spinal epidural anesthesia, combined spinal epidural anesthesia with indwelling catheter for 24 hrs) on pain after elective cesarean section.

regional analgesia is the most effective way of providing analgesia during labor and delivery. by using a combination of local anesthetics and opioids, it is often possible to avoid motor block. spinal anesthesia is suitable for most elective cesarean sections. epidural anesthesia and in particular catheter based epidural anesthesia allow a gradual extension of anesthesia and are suitable for prolonged treatment of postoperative pain. it is unclear which anesthetic technique provides better pain relief after cesarean section. this prospective, randomized study compares the effectiveness of three types of regional anesthetic techniques (spinal anesthesia, combined spinal epidural anesthesia, combined spinal epidural anesthesia with indwelling catheter for 24 hrs) on pain after elective cesarean section.

Eligibility criteria:
inclusion criteria: * female patients aged greater than or equal to 18 years * patients without severe illnesses (american society of anaesthesiologists \[asa\] grade ii-iii) * patients for elective cesarean sections * informing patients about risks and complications of anesthesia until 24 hrs before operation exclusion criteria: * lacking willingness to regional procedures * no offered patient information and written informed consent * persons without the capacity to consent * unability of german language use * preterm delivery \< 28 weeks of pregnancy * chronic pain or chronic analgesic intake in medical history * alcohol, dope and medication abuse * psychiatric disease in medical history * baby death after delivery * anxiolytic medication * allergy to local anaesthetics * history of bleeding tendency * eclampsia and hellp syndrome * elective section out work routine time * participation in another clinical trial during the trial, one month before screening and three months after screening

Keywords: elective cesarean sections postoperative pain level spinal anesthesia combined spinal epidural anesthesia epidural catheter
wearable sensor-based balance training for patients with knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: knee osteoarthritis (koa) is one of the leading causes of lower limb disability among the elderly and can cause loss of knee joint proprioception that contributes towards deterioration of postural balance. maintaining a good postural stability is essential while performing everyday functional activities and to avoid falls. exercise training has been reported to reduce pain as well as improve performance of functional tasks in patients with koa however compliance to exercise can be challenging due to pain, lack of motivation and traditional nature of exercise that can easily overtax patients. furthermore, there are not exercise programs that are specifically designed for patients with koa in order to address lost knee joint proprioception. recent studies have also demonstrated that visual feedback during exercise can enhance the benefits of exercise training. therefore, the aim of the proposed study is to implement an interactive sensor-based exercise training to improve postural balance, gait and activities of daily living in patients with koa.

the exercise intervention procedure is based on wearable sensor game-based balance-training program (exergame). subjects will perform progressive balance exercises such as ankle reaching or weight shifting, obstacle crossing, and ankle trail making task (i.e. motor-cognitive task). real-time visual/audio lower-extremity joint motion feedback will be provided using wearable sensors (legsys, biosensics llc, cambridge, ma, usa) to assist and encourage subjects to accurately execute each exercise task. the same wearable sensor technology is also used to quantify changes in balance and gait. changes in balance, gait, fear of falling, physical activity, pain, and quality of life parameters will be assessed at the beginning and conclusion of the training program. subjects will perform sensor-based interactive balance training (on computer screen), 2 x week, for a period of 6 weeks. the training consists of three balance tasks shown on a computer screen (1. ankle reaching task or weight shifting , 2. obstacle negotiation task, and 3. ankle trail making task (i.e. motor-cognitive task) intended to improve postural stability.

Eligibility criteria:
inclusion criteria: * age 18 and above * ability to walk 50 m independently (with or without aid) * ability to stand for 5 minutes . exclusion criteria: * disorder other than osteoarthritis that may severely affect gait and balance

Keywords: postural balance pain gait physical activity level
complications, outcomes and revisions following hiatal hernia repair with miromesh

Conditions: Hiatal Hernia With Gastroesophageal Reflux Disease; Gastroesophageal Reflux; GERD

Summary: investigator will identify a consecutive cohort of patients who have undergone a hiatal hernia repair and are at least 6 months post index procedure.

planned sample size: at minimum of 70 consecutive subjects at least 6-months post-index procedure study population: a consecutive cohort of patients who have undergone a hiatal hernia repair with miromesh. primary objective: characterize the procedural and early post-operative safety profile of miromesh when used as reinforcement in hiatal hernia repair. secondary objectives a retrospective chart review will identify the appropriate cohort with a prospective follow-up survey to acquire safety and outcome information. a retrospective chart review of appropriate subjects. data to be acquired will be: preoperative - chart review * gender * date of birth * weight * body mass index * specific diagnosis * demeester score * 24 hour ph test (% acid exposure in 24 hours) * gastroesophageal reflux disease health related quality of life (gerd-hrql) score peri-operative preoperative - chart review * date of surgery * number of stitches used to close wound * paraesophageal hernia type * mesh shape * mesh size used * attachment technique * length of stay * complications post-operative (with-in 1 month of surgery) preoperative - chart review * complications (mesh related) * complications (procedure related) * prolonged dysphagia (y/n) * stenosis (y/n) * dilations (y/n) * esophagogastroduodenoscopy or upper gastrointestinal series documented hernia recurrence * gerd-hrql score prospective institutional review board approved follow-up telephone interview * have you had a revision surgery? * gerd-hrql score * how satisfied are you with the procedure? * have you used proton pump inhibitors in the last 3 months * how likely are you to recommend this procedure to a loved one?

Eligibility criteria:
inclusion criteria: * had a hiatal hernia repair with miromesh greater than 6 months prior to study exclusion criteria: * n/a
amevive® pregnancy registry

Conditions: Pregnancy

Summary: this is an observational, exposure-registration and follow-up study, to be conducted in the united states (us). the amevive® pregnancy exposure registry is designed to monitor pregnant subjects and fetuses exposed to amevive® in order to detect any potential increase in the risk of major birth defects. the amevive® pregnancy exposure registry is sponsored by astellas pharma global development and will be managed by inc research. the registry will be monitored by an independent advisory committee of external experts in relevant specialties of teratology, epidemiology, maternal and fetal medicine, and infectious disease medicine (external member details available upon request).

prospective reports will be collected from pregnant subjects, health care provider (hcp), or astellas product safety management staff. data from the pregnant subjects will be collected at 4 to 5 months of pregnancy by telephone interviews with the registry. the registry will also contact the subject at 2 months and 12 months after the estimated delivery date (edd) for post-natal \& pediatric follow-up. the registry will confirm the information collected from the subject with the hcp by telephone interviews with the registry, forms mailed/faxed to the registry, electronic forms/queries sent to the registry, or a combination of these methods. if a live birth is reported, the infant's hcp will be contacted for the pediatric follow-up at 2 months and 12 months of age. if a birth defect is reported, targeted follow-up will be conducted.

Eligibility criteria:
inclusion criteria: * have been exposed to amevive® within 8 weeks prior to conception or at any time during pregnancy * provide sufficient information to determine that the pregnancy is prospectively registered (i.e., the outcome of pregnancy must be unknown prospectively) * provide verbal consent to participate in the registry, and * verbally provide the contact information for herself, her healthcare provider (hcp), and the infant's hcp (if applicable) exclusion criteria: * none

Keywords: pregnancy amevive alefacept registry psoriasis