Kornimate/medical-research-clean huggingface dataset:
exercises with elastic bands and stability in proprioception and strength in female athletes of taekwondo

Conditions: Proprioceptive Disorders

Summary: strength and proprioception exercises are used to improve the strength and unipodal balance of lower limbs in taekwondo players. the moments of unipodal support in taekwondo require a great demand that is necessary to adapt the athlete through the development of strength and proprioception. the main objective of the study is to assess the effectiveness of strength work with elastic bands and balance exercises in increasing strength and unipodal proprioception in taekwondists aged 18 to 30 years. randomized, single blind clinical study 30 taekwondists will be randomized to the two study groups: experimental (strength training and proprioception) and control (without intervention). the intervention will last 4 weeks, with 2 weekly sessions each session will be approximately 15 minutes each. the study variables will be: unipodal muscle strength (jump test), and lower limb balance (y-balance test). the sample distribution will be calculated using a kolmogorov-smmirnof analysis. the changes after each evaluation will be analyzed with the t-student test and with an anova of repeated measures the intra and intersubject effect will be observed. the effect size will be calculated using cohen's formula. after the training period it is intended to obtain improvement in the strength of the lower limbs, as well as an increase in balance during unipodal support during the execution of a movement.


Eligibility criteria:
inclusion criteria: * female taekwondo players * age range of 18 to 30 years * more than 2 years of sports practice of taekwondo, federated * currently participate in regional or national competitions. exclusion criteria: * participants who have some type of musculoskeletal lesion in the lower limbs * that are belts below the color green * have not competed in the last year in any regional or national competition. * have not signed the informed consent document

Keywords: taekwondo strength balance theraband proprioception
effects of mother-sung lullabies on infant pain and maternal anxiety

Conditions: Pain; Anxiety

Summary: childhood pain can cause long-term and psychologically harmful effects. music can reduce pain and anxiety. this study aimed to investigate the effects of the mother-sung lullaby during vaccine administration on vaccine-induced pain in babies and anxiety in mothers.

this study aimed to investigate the effects of the mother-sung lullaby during vaccine administration on vaccine-induced pain in babies and anxiety in mothers. two family health centers in turkey between march 4, 2020, and august 28, 2020. a total of 60 babies who received the bacille calmette-guérin vaccine and their mothers.these babies were randomly assigned to one of two groups, including 30 babies in the lullaby group and 30 babies in the control group. data on descriptive information for all babies and mothers were collected through face-to-face interviews with the mothers before vaccination. heart rate, oxygen saturation, and crying duration were measured in all babies. heart rate and oxygen saturation of the babies were recorded using a pulse oximeter during and after vaccine administration. the crying time, measured for up to 30 seconds after vaccination, was recorded as the total cry time (using video seconds). the pain score was evaluated by two observers using the neonatal infant pain scale, based on video recordings obtained during and after vaccine administration. in addition, mothers' anxiety scores were measured using the "state anxiety inventory," both before and after vaccination.

Eligibility criteria:
inclusion criteria: * gestational age of 37-42 weeks * postnatal age at full two month * receiving the bacille calmette-guérin vaccine * birth weight of 2500 gr or higher * no congenital anomalies * stable general condition * not taking any pain medication before vaccination * mothers were required to be older than 18 years and agree to participate in the study exclusion criteria: * taking analgesic medication within 4 hours before the procedure * parents not willing to participate in research.

Keywords: anxiety pain vaccination mother nursing
nicotinic acid in hemodialysis patients with hyperphosphatemia

Conditions: Hyperphosphatemia

Summary: with calcium carbonate as the positive control drug, to observe the effectiveness and safety of nicotinic acid in hemodialysis patients with hyperphosphatemia

hyperphosphatemia is an important risk factor affecting long-term survival in patients with hemodialysis. nicotinic acids, as well as its metabolites nicotinamide, were found to inhibit the sodium-phosphorus co-transporter on animal intestines. several studies from other countries demonstrated that nicotinamide can reduce blood phosphorus levels in end-stage kidney disease patients. the purpose of this study was to investigate the effectiveness and safety of nicotinic acids on hyperphosphatemia in hemodialysis patients of ethnic han live in china. the study is a prospective, randomized, double-blind, placebo-controlled crossover study. eligible patients will be randomized to 6 wk of nicotinic acids or calcium carbonate. after a 2-wk washout period, patients switched to 6 wk of the alternative therapy. the primary measurement is the change in serum phosphorus during the whole term of each arm. statistical analysis will be performed using two-sample paired-group t test.the significance level of the analysis was set to 0.05. all other adverse reactions will be analysed and reported, if there.

Eligibility criteria:
inclusion criteria: ethnic han live in china, end-stage renal disease（esrd）patients treated with hemodialysis ≥ 3 months, between 18 and 80 years of age, serum phosphorus \> 1.78 mmol/l, capable of giving informed consent exclusion criteria: be allergic to nicotinic acids, dysphagia, pregnant, current medication regimen including niacin or niacinamide active liver disease, peptic ulcer disease, full resection of parathyroid, malignancy, quit hemodialysis

Keywords: hemodialysis,hyperphosphatemia,nicotinic acids
seroprevalence of sars-cov-2 in strasbourg university hospital, strasbourg, france (covid-19)

Conditions: SARS-CoV-2 Serological Status; SARS-CoV-2 Seroprevalence

Summary: covid-19 is a new emerging disease caused by infection with the sars-cov-2 coronavirus, with no specific therapeutic options. since the end of february 2020, the strasbourg university hospital (hus) had faced a sudden increase of patients with covid-19 resulted from a sars-cov-2 superspreading event (religious meeting). infected individuals went to regional hospitals, and this led to a cluster of infected healthcare workers at the strasbourg university hospitals from the first week of march. to date, several hundred strasbourg hospital workers have presented a sars-cov-2 infection confirmed by the rt-pcr test from a nasopharyngeal sample. most of them developed a mild form of covid-19. it is important to understand how far the infection has spread in the hospital staff, and to which extent the individuals who have been infected develop antibodies against sars-cov-2.


Eligibility criteria:
inclusion criteria: * any person, male or female, over 18 years of age at the time of signing the consent * any person affiliated to a social health insurance scheme * any person able to understand the objectives and risks related to research and to give an informed, dated and signed consent * any person who is part of hus staff and working at hus at the time of the pandemic, including residents affiliated with hus and assigned to general hospitals in the region * any symptomatic person with a positive covid result (pcr + group) or negative (pcr- group) with a rt-pcr test carried out at least 10 days before inclusion, or any person, for which no covid pcr was performed (group " no pcr") exclusion criteria: * person in exclusion period (determined by a previous or ongoing study), * inability to give clear information (person in an emergency, difficulty understanding the subject, etc.) * person under safeguard of justice * person under guardianship or curatorship

Keywords: covid-19 sars-cov-2 humoral response t-cell response
appropriateness of aspirin use in medical outpatients

Conditions: Primary Prevention of Cardiovascular Diseases

Summary: this study aims to describe the demographic characteristics and current status of the aspirin use for primary and secondary prevention of cardiovascular diseases in a large, multicenter nationwide study

although the benefit of aspirin use for secondary prevention is well established, its role in the primary prevention of cardiovascular diseases remains controversial. differences in primary prevention guidelines may lead to underuse of aspirin in high-risk patients and overuse in low-risk patients. this study aims to describe the demographic characteristics and current status of the aspirin use for primary and secondary prevention of cardiovascular diseases in a large, multicenter nationwide study. the assos trial (appropriateness of aspirin use in medical outpatients: a multicenter, observational study) will be an observational, multicenter, and non-interventional study conducted in turkey. approximately 5000 patients will be enrolled in this non-interventional study. all the data will be collected at one point in time and current clinical practice will be evaluated. the investigators will enroll all consecutive patients admitted to the outpatient cardiology clinics from january 30, 2018, through may 30, 2018, who were at least 18 years of age, provided written informed consent, and currently treated with aspirin (80-325 mg)within the last 30 days. hospital-based cardiologists in public units will be invited to participate in the study. patients will be stratified into 2 categories based on the presence or absence of atherosclerotic cardiovascular disease; secondary prevention group and primary prevention group, respectively. appropriateness of aspirin use in primary prevention group will be evaluated according to the us preventive services task force (uspstf) and european society of cardiology (esc) guidelines. physicians will complete a standardized survey form to collect information on patient clinical characteristics, cardiovascular risk factors, medical history, clinical examination, laboratory test results, and medications. patients' risk factors for colorectal cancer and gastrointestinal bleeding will also be questioned. assos registry will be the largest and most comprehensive study in turkey evaluating aspirin use. the results of this study will provide valuable information regarding the potential misuse of aspirin in a real-world setting.

Eligibility criteria:
inclusion criteria: * patients using aspirin 18 years and older exclusion criteria: * patients under 18 years of age * patients who do not want to participate in our study * patients who do not use aspirin
non-invasive assessment of mechano-chemical properties of urine proteins by hybrid brillouin-raman spectroscopy

Conditions: Nephrotic Syndrome

Summary: the proteinuria is widely recognized as a marker of kidney disease severity, as well as the predictor of renal function decline, cardiovascular outcomes, and all-cause mortality. however, the severity of kidney disease progression and these outcomes differs among patients with various amount of proteinuria. the potential mechanism underlining this disparity may be relevant to the quality and quantity of filtered proteins, especially their mechano-chemical properties such as physical viscosity and stiffness, amino-acid sequence, and molecular weight (low, middle and high molecular weight proteins). the goal of the current project is to develop and validate combined brillouin \& surface-enhanced raman scattering (sers) spectroscopy technique for simultaneous non-contact assessment of visco-elastic and chemical properties of urine proteins as biomarkers of kidney disease. systematic studies of these properties of proteins in urine samples to be taken from diseased and healthy subjects will be cross-validated by liquid chromatography-mass spectrometry (lcms). the project ultimately aims for the development of an optical spectroscopic sensor for rapid, non-contact monitoring of urine samples from patients in clinical settings.


Eligibility criteria:
inclusion criteria: * both male and female patients with any ethnic group, aged between 18-65 years old * newly diagnosed patients with glomerulonephritis and different range of proteinuria exclusion criteria: * patients aged \ 65 years, * egfr\<60 ml/min, * pregnant females, * patients with diabetes mellitus, cancer, infectious diseases, and other life-treating comorbidities/conditions

Keywords: urinary proteins brillouin spectroscopy surface enhanced raman spectroscopy proteomics non-invasive assessment
a controlled-study of fenofibrate 145 mg and ezetimibe 10 mg in type iib dyslipidemic patients with features of the metabolic syndrome

Conditions: Hyperlipidemia Combined

Summary: type iib dyslipidemia is characterized by elevated triglycerides (tg ³ 150 mg/dl), and elevated ldl-c levels (³160 mg/dl). when in addition, hdl-c is low, the presence of the lipid triad, elevated tg and ldl-c and low levels of hdl-c, seems to confer additional chd risk in this type of patient, compared to elevated ldl-c alone.coadministration of fenofibrate and ezetimibe could provide a complementary efficacy therapy and improve the atherogenic profile of this patient population.


Eligibility criteria:
inclusion criteria: * type iib dyslipidemia. exclusion criteria: * known hypersensitivity to fibrates or ezetimibe. pregnant or lactating women. contra-indication to fenofibrate or ezetimibe.

Keywords: hyperlipidemia combined and features of the metabolic syndrome, efficacy combination fenofibrate ezetimibe
a cohort study of the intestinal microbiota of premature infants

Conditions: Necrotizing Enterocolitis; Bronchopulmonary Dysplasia; Growth Failure

Summary: premature infants are at risk for a variety of diseases, the investigators would like to learn more about why some premature babies are at higher risk and some are protected from these diseases. scientists at uc davis and other universities have developed new ways to measure the bacteria and a large number of small molecules in specimens of infant blood, urine, stomach fluid and poop and in mother's milk. these discoveries allow us to consider questions that were impossible to answer before these new techniques were developed. one such question is whether the bacteria in the poop of a premature baby can help us predict the baby's risk for developing infection or a common and serious disease of premature infants called necrotizing enterocolitis. a second question is whether the dna of a premature baby (obtained from saliva with a q-tip) can predict higher risk for diseases of premature babies.

samples from eligible infants will be collected and stored for future comparisons. these samples include stool specimens from a messy diaper twice weekly, urine samples from cotton balls in the diaper once weekly, a small sample of stomach fluid once a week just prior to a feeding obtained through the feeding tube, a sample of mom's milk once a week, left-over blood from lab draws, and a sample of saliva on one occasion. the analysis of key specimens from this cohort will allow us to study the impact of the bacteria in the intestines on outcomes like growth and common diseases of premature infants.

Eligibility criteria:
inclusion criteria: * gestational age \< 33 weeks at birth exclusion criteria: * none

Keywords: microbiota metabolome lipidome
positive psychotherapy in acquired brain injury (abi) rehabilitation

Conditions: Acquired Brain Injury; Emotional Distress

Summary: stroke, head injury and other forms of brain injury are a major cause of physical, psychological and social disability in the adult population. psychological distress is common following brain injury, but the evidence base for specific psychotherapeutic methods in this population is limited, and standard treatment approaches may not be suitable. recently there has been a growing interest in positive psychology - the study of wellbeing, positive emotions and characteristics, and personal growth. the investigators believe that positive psychotherapy interventions may be beneficial after acquired brain injury, to reduce psychological morbidity. because such interventions have not previously been applied in this population, the investigators propose to conduct a pilot randomised controlled trial to examine the feasibility of a brief positive psychotherapy intervention in an out-patient setting. this project will produce essential information to allow us to plan future full-scale clinical trials in this area.


Eligibility criteria:
inclusion criteria: * aged 18 years or over; * diagnosis of stroke or acquired brain injury (confirmed clinically and/or radiologically); * between 3 and 12 months post-injury at time of recruitment; * presence of emotional distress (score in moderate or above range on at least one sub-scale of the depression anxiety stress scales; dass-21); * medically stable; * able to consent to research. exclusion criteria: * significant communication impairments that would preclude participation; * diagnosis of mild traumatic brain injury (due to the known additional complexities contributing to outcome in this population); * comorbid developmental learning disability or degenerative neurological condition. pre-injury history of mood disorder will not lead to exclusion.

Keywords: stroke acquired brain injury
association between fluid administration, oxytocin administration, and fetal heart rate changes

Conditions: Pregnancy; Labor Pain

Summary: fetal heart rate patterns are an important parameter in the diagnosis of non-reassuring fetal status. combined-spinal epidural analgesia is a method of initiating labor analgesia used by approximately 90% of the parturients at prentice women's hospital. optimizing the variables which could affect fetal heart rate patterns at the time of initiation of analgesia, such as fluid administration and oxytocin management, could help us provide better care for our patients and their fetuses. hypotheses: patients who receive a 1000 ml fluid bolus and lower rates of oxytocin administration will have fewer non-reassuring fetal heart rate (fhr) changes.

informed, written consent will be obtained. at the time of request for labor analgesia, group assignment will be determined by opening an opaque envelope. patients will be randomized to one of four groups. all subjects will receive a maintenance infusion of 125 ml lactated ringers (lr) solution throughout the study. for patients in groups a or b, an intravenous bolus of 1000 ml lr will be initiated when the patient is positioned for epidural placement. the bolus will be administered through a free-flowing wide open intravenous catheter until complete. patients in groups c and d will not receive any additional fluid bolus and will only receive the maintenance infusion of 125 ml lr during the study period. blinding will be maintained by the labor and delivery nurse by covering up the lr bolus fluid bag. if the patient is randomized to groups b or d, the dose of oxytocin currently being administered will be halved and not increased for the duration of the study period (60 minutes after the initiation of cse).

Eligibility criteria:
inclusion criteria: * age 18 and over * healthy nulliparous or multiparous women * term (\>36 week gestation) * singleton pregnancy * spontaneous labor or spontaneous rupture of membranes * receive oxytocin * request neuraxial analgesia exclusion criteria: * under 18 years old * presence of any systemic disease (ex: diabetes mellitus, hypertension, preeclampsia * use of chronic analgesic medications * prior administration of system opioid labor analgesia * non-vertex presentation * induction of labor * contraindication to neuraxial analgesia

Keywords: oxytocin labor, obstetric non-reassuring fetal heart rate epidural
prone position during ecmo in pediatric patients with severe ards

Conditions: Pediatric Acute Respiratory Distress Syndrome; Extracorporeal Membrane Oxygenation

Summary: in 2023, the second pediatric acute lung injury consensus conference (palicc-2) updated the diagnostic and management guidelines for pediatric acute respiratory distress syndrome (pards). the guidelines do not provide sufficient evidence-based recommendations on whether prone positioning ventilation is necessary for severe pards patients. however, the effectiveness of extracorporeal membrane oxygenation (ecmo) in treating severe pards has been fluctuating around 70% according to recent data from extracorporeal life support organization (elso). in 2018, the randomized evaluation of sedation titration for respiratory failure (restore) study group conducted a retrospective analysis and concluded that ecmo does not significantly improve survival rates for severe pards. however, this retrospective study mainly focused on data from north america, with significant variations in annual ecmo support cases among different centers, which may introduce bias. with advancements in ecmo technology and materials, ecmo has become safer and easier to operate. in recent years, pediatric ecmo support technology has rapidly grown in mainland china and is increasingly being widely used domestically to rescue more children promptly. ecmo can also serve as a salvage measure for severely ards children who have failed conventional mechanical ventilation treatment. when optimizing ventilator parameters (titrating positive end expiratory pressure (peep) levels, neuromuscular blockers, prone positioning), strict fluid management alone cannot maintain satisfactory oxygenation (p/f\ 40 for over 4 hours or oi \>20 for over 24 hours), initiating ecmo can achieve lung-protective ventilation strategies with ultra-low tidal volumes to minimize ventilator-associated lung injury.


Eligibility criteria:
inclusion criteria: * severe pards and meets the criteria for ecmo support, has received ecmo support for less than 48 hours. * informed consent obtained from the child's direct/legal guardian exclusion criteria: 1. age \ 18 years old. 2. ecmo initiated for more than 48 hours. 3. children who have undergone cardiopulmonary resuscitation (cpr) for more than 10 minutes before ecmo initiation without restoration of spontaneous circulation, or children undergoing extracorporeal cardiopulmonary resuscitation (ecpr). 4. presence of irreversible brain injury or intracranial hypertension. 5. children with irreversible lung disease awaiting lung transplantation. 6. children with abdominal trauma or postoperative acute respiratory distress syndrome (ards). 7. children in whom percutaneous cannulation cannot be performed due to unstable hemodynamics within the first 48 hours after ecmo support initiation. 8. other contraindications for performing percutaneous cannulation. 9. liver failure. 10. burn area \>20% body surface area (bsa).

Keywords: extracorporeal membrane oxygenation pediatric acute respiratory distress syndrome prone position ventilation