Kornimate/medical-research-clean huggingface dataset:
utility of anatometabolic imaging for radiation treatment planning for lung cancer

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: this is a research study for patients with inoperable lung cancer called non-small cell lung cancer (nsclc). currently, the information from a radiological test, computed tomography (ct) scan of the chest, is used to design the best arrangement of radiation beams which will kill tumor cells and still spare the normal parts of lungs and other normal organs in the chest. the purpose of this study is to explore whether adding information from another radiological test, called positron emission tomography (pet), will improve the accuracy of the radiation beam arrangement designed to treat lung cancer. a pet scan is a way to picture the biochemistry of tissues and organs: of how tissues in the body take up glucose, a normal nutrient of the body. the researchers will attempt to create radiation treatment plans from pet images alone and compare differences between hypothetical plans and standard-of-care ct-based radiation treatment plans. because there is honest uncertainty about the contribution of pet to radiation treatment planning, it is possible that there will be no difference between a ct-based treatment plan and one resulting from pet information. it is also possible that the addition of pet may result in a radiation beam arrangement that may better control lung cancer. the addition of pet may also result in treating less normal tissues, which may lower the risk of radiation side effects. this study will provide the preliminary data necessary to design a larger clinical trial that may define the role of pet in radiation treatment planning.


Eligibility criteria:
inclusion criteria: * histologically confirmed locally advanced nsclc (squamous, large cell undifferentiated or adenocarcinoma). * disease limited to the thorax, adjacent mediastinum and neurovascular structures, and supraclavicular or scalene lymph node area, as defined by the ajcc staging system. this includes patients with stage iiia and iiib disease. * performance status of 0-2 by southwest oncology group criteria. * medically inoperable patients (stage i or ii) * locoregional recurrent tumor following surgery will be eligible provided they meet other eligibility criteria.

Keywords: diagnostic imaging
incobotulinumtoxina (xeomin) versus placebo in the treatment of post-stroke spasticity of the upper limb

Conditions: Post-stroke Upper Limb Spasticity

Summary: incobotulinumtoxina (xeomin) is a botulinum toxin type a preparation free from complexing proteins, i.e. free from proteins other than the active toxin. injected into the muscle, incobotulinumtoxina (xeomin) causes local weakening. botulinum toxin type a is widely used for treatment of various neurological conditions. this study will investigate the efficacy and safety of incobotulinumtoxina (xeomin) in the treatment of post-stroke spasticity of the upper limb.


Eligibility criteria:
main inclusion criteria: * female or male patients ≥ 18 years * ≥ 6 months since the last stroke, diagnosed by an appropriate health care professional (e.g., neurologist) * focal spasticity with ≥ 2 points on the ashworth scale in the wrist flexors with clinical pattern flexed wrist * focal spasticity with ≥ 2 points on the ashworth scale in the fingers flexors with clinical pattern clenched fist * for pre-treated patients only: source documentation of the most recent injection session with botulinum toxin and sufficient therapeutic response for flexed wrist and clenched fist * for pre-treated patients only: the most recent injection with botulinum toxin must have been maximal 50 units botox® or 200 units dysport® or 2000 units neurobloc® (type b preparation) per each of these flexors: carpi ulnaris, digitorum superficialis, digitorum profundus * for pre-treated patients only: the most recent injection with botulinum toxin must have been maximal 60 units botox® or 240 units dysport® or 2400 units neurobloc® (type b preparation) for flexor carpi radialis main exclusion criteria: * spasticity of any other origin than stroke * previous treatment with botulinum toxin of any serotype and for any body region within the 4 months prior to screening (visit 1, day -7) * planned concomitant treatment with botulinum toxin of any serotype and for any body region * previous or planned treatment with phenol- or alcohol-injection in the target limb * previous surgical treatment of spasticity in the target muscle(s) * fixed contracture, defined as severe restriction of the range of joint movement on passive stretch * severe atrophy of the target limb muscles
validation of software for assessment of atrial fibrillation from data acquired by a wearable smartwatch

Conditions: Atrial Fibrillation

Summary: the goal of this study is to validate the fitbit ecg software algorithm's ability to detect atrial fibrillation using data derived from a fitbit wrist-worn consumer device that features a single lead ecg. the performance of the software application will be measured against centralized core lab physician-adjudicated 12-lead ecg tracings from fda cleared ecg monitors as reference standards. the fitbit software is intended as a pre-screening technology. it should identify candidates who may benefit from further evaluation. the software is not intended to be a diagnostic system.


Eligibility criteria:
inclusion criteria: * women and men 22 years of age or older * capable of giving informed consent * sufficient manual dexterity to capture an ecg from the fitbit wrist-worn device. * subjects in the atrial fibrillation (af) cohort must have a known history of af and must be in -af at the time of enrollment based on the screening ecg exclusion criteria: * anti-arrhythmic (rhythm control) medication use (such as amiodarone or flecainide) * cardiac pacemaker or implantable cardioverter-defibrillator * history of a life-threatening rhythm such as ventricular tachycardia or ventricular fibrillation * subjects in the sinus rhythm (sr) cohort should not have any history of atrial fibrillation and should not be in atrial fibrillation or other atrial arrhythmia at the time of enrollment based on the screening ecg
effect of ao training on gross motor function in children with spastic cerebral palsy

Conditions: Diplegic Spastic Cerebral Palsy

Summary: the study was conducted to examine the impact of the action observation training (aot) on gross motor function in children with spastic cerebral palsy.

thirty children with spastic diplegic cerebral palsy aged from 4 to 7 years were randomly allocated into two groups of equal number; study group (a) and control group (b). both groups received designed physical therapy program for 45 minutes, three times/ per week for two successive months. in addition, study group received action observation (ao) training for 30 minutes per session. all phases of gait cycle and functional ability of all children participating in both groups was assessed by kenovia software and gross motor function measure (gmfm) walking, running and jumping domain.

Eligibility criteria:
inclusion criteria: age ranges from 4 - 7 years. level ι - π according to gross motor functional classification system (gmfcs) (appendix ii). grade 1, +1 and 2 of the modified ashworth scale (appendix iii). able to follow verbal commands and instructions. exclusion criteria: * significant visual or auditory impairments structural or fixed soft tissue deformities of lower extremities. perception disorders. botox injection in the lower extremity in the past 6 months.
immuno-epidemiological and socio-behavioral evaluation of release of sterile male aedes albopictus mosquitoes on human-vector contacts

Conditions: Mosquito Bite

Summary: this trial is based on 2 complementary components, named expalbo biomarker and capalbo questionnaire 1. expalbo biomarker (exposure to the aedes albopictus mosquito): this component concerns the epidemiological evaluation of the effectiveness of the release of sterile male mosquitoes on the level of exposure of individuals to the bites of the tiger mosquito through the use of a new immunological biomarker of the human-vector contact, developed over the past 20 years by the ird-mivegec team. indeed, when a person is bitten by a mosquito, he or she develops a defence reaction, called an immune reaction, against the mosquito's saliva. the main objective of this study is to measure this immune response, and more specifically the antibody response specifically directed against compounds (peptide = small fragment of a protein) in mosquito saliva, and to determine whether this anti-saliva antibody response, and therefore exposure to mosquito bites, decreases when the mosquito control strategy is applied. 2. capalbo questionnaire: this component is concerned with assessing the impact of sterile male mosquito releases on perceptions and practices related to exposure to aedes albopictus based on population-based questionnaire surveys. the main objective of these surveys is to determine whether changes in objective exposure to aedes albopictus mosquitoes are associated with changes in the perception of the nuisance and in the lifestyle habits of respondents, particularly those related to the prevention of mosquito bites (such as the use of repellents or mosquito nets).


Eligibility criteria:
inclusion criteria: * to inhabit on a regular basis in the intervention/control area * to speak french
stellate ganglion block in beating heart surgery

Conditions: Cardiac Arrythmias

Summary: studies suggest that off-pump coronary artery bypass surgery is associated with improved outcomes when compared to on-pump coronary artery bypass. many studies have shown that off-pump coronary bypass surgery reduces patient morbidity and mortality. manipulation of the coronary arteries during cardiac surgery can stimulate the adjacent post-ganglionic sympathetic fibers and mimic stellate ganglion stimulation ,stellate ganglion block (sgb) can interrupt this reflex by decreasing the efferent cervical sympathetic outflows.

when adopting off-pump surgery , the cardiac surgery team must adopt new techniques to handle a beating heart and the variations in hemodynamics that can occur when performing this type of procedure the incidence rate of cardiac arrhythmia occurring during and after surgery is one of the major complication in open heart surgery. in addition , intraoperative hemodynamic disorders, caused by changes in plasma levels of epinephrine and norepinephrine after surgical stimulation , are some of challenges for patients undergoing off-pump coronary artery bypass surgery. hemodynamic disruption leads to myocardial ischemia, resulting in increased incidence of cardiovascular events and mortality. stellate ganglion is formed by the fusion of inferior cervical and first thoracic sympathetic ganglia and is located behind the subclavian artery and anterior to the first rib. the inferior cervical cardiac nerves arise from the medial aspect of the stellate ganglia and provide the cardio-accelerator nerve fibers to the cardiac plexus. stellate ganglion stimulation augments peak systolic pressure, and the enhanced myocardial contractility is secondary to stimulation by postganglionic nerve fibers which traverse from stellate ganglion down the great vessels and along the coronary arteries into the myocardium.the blockage of inferior cervical cardiac nerves is responsible for the bradycardia seen following sgb. sgb has been shown to prevent and control perioperative hypertension induced by increased sympathetic activity.

Eligibility criteria:
inclusion criteria: * patients undergoing elective off-pump coronary artery bypass grafting surgery * patients with an ejection fraction of more than 50% * creatinine level of less than 2.0 mg / 100 ml * no evidence of heart failure * no significant chronic obstructive lung disease * age of less than 60 years exclusion criteria: * emergency surgery * patients on thrombolytic therapy * patients with coagulation disorders * patients requiring heart lung machine * patients with clinical contraindications to sgb ( including allergy to local anesthetic , carotid vascular disease as defined by ipsilateral prior carotid endarterectomy or carotid stent, superficial infection at the proposed puncture site, contralateral phrenic or laryngeal nerve palsies , and severe chronic obstructive pulmonary disease ) * patients with history of atrial fibrillation
comparison of two strategies to realize apnea test for the diagnostic of brain death in potential organ donors (cpapnee study)

Conditions: Alternative Method of Apnea Test

Summary: clinical diagnostic of brain death requires a non-reactive coma, absence of brain stem reflex, and absence of spontaneous breathing. the confirmation of absence of spontaneous breathing is established the apnea test (according to the american academy of neurology's guidelines). however this test may lead to complications (acute hypoxemia, ventilatory and cardiocirculatory disorders) and reduces significantly the number of lung transplants. some data suggest modifying the apnea test : replace the ventilator switching off with continuous positive airway pressure (cpap) use. these studies showed that this alternative method (cpap) increased the level of lung harvest but they were not sufficient because these studies were monocentric, non randomized and with little patients,. that why the aim of the present study is to compare the standard strategy and cpap strategy with a prospective, multicenter, randomized study.


Eligibility criteria:
inclusion criteria: * age : from 18 to 70 years * neurological signs evoking cerebral ischemia exclusion criteria: * severe hypoxemia (pao2/fio2 \< 200) with controlled ventilation (fio2: 100%) * hypothermia \< 36°c * obesity (bmi ≥ 40) with documented hypopnoea * intractable hypotension despite optimal filling and catecholamine doses \> 1µg.kg.min * patients with contraindication for organs harvesting. * documented chronic respiratory failure * progressive infectious acute respiratory disease * family opposition to subject's participation in the study
correlation between efficacy of osimertinib and egfr t790m status and ratio via ddpcr in nsclc

Conditions: EGFR T790M; Osimertinib; Non-small Cell Lung Cancer; ddPCR

Summary: liquid biopsy is emerging as an essential tool in tumor monitoring and a potential alternative and supplement to tissue biopsy for tumor genotyping, especially in relapsed or metastatic diseases. liquid biopsy methods for detecting t790m in ctdna can be qualitative or quantitative, including amplification refractory mutation system pcr (arms-pcr), digital droplet polymerase chain reaction (ddpcr), and next generation sequencing (ngs)-based methods. comparison of multiple detecting platform for egfr mutations in plasma samples has been undertaken in studies to determine the most feasible assay in clinical practice. in this study, we will investigate the usefulness of ddpcr for quantitative detection of egfr t790m mutation in peripheral blood, and compared the utility of ddpcr and ngs for guiding decisions regarding osimertinib therapy in nsclc patients who had develop resistance to first- or second generation egfr-tkis.


Eligibility criteria:
inclusion criteria: * histologically/cytologically confirmed stage iv nsclc patients harboring sensitizing egfr mutations; * progression from first or second-generation egfr-tki confirmed by radiographic imaging; * received both ngs test and ddpcr from peripheral blood simultaneously. exclusion criteria: * progression from first- or second-generation egfr-tkis as adjuvant therapy; * having received third-generation egfr-tkis prior to the gene tests; * having received ngs test only or ddpcr test only.
muscle strength in shoulder and neck muscles in tension type headache patients. effect of specific strength training

Conditions: Tension-Type Headache

Summary: background: tension type headache (tth) is highly frequent and is of great socio-economic importance. andersen et al. 2008 has shown that maximal muscle strength is reduced in women with trapezius myalgia. it is shown that specific strength training leads to prolonged pain relief. aim:test: to investigate the impact of tth on shoulder, and neck muscle strength in patients with tth compared to healthy controls. intervention: to investigate the effect of specific strength training on patients with tth compared with control group, receiving training in ergonomics. method: test part. 60 tension headache patients, 30 healthy. muscle testing of neck and shoulder. testing conducted by blinded research assistant. intervention group: 60 patients with tension headache randomly assigned to the intervention group or control group. intervention with specific strength training program runs for 10 weeks. the control group will be trained in ergonomics. 3 months follow up.


Eligibility criteria:
inclusion criteria: * tension-type headache(tth), inclusion criteria were age between 18 and 65 years and for patients a diagnosis of tth ≥8 headache days per month, and ≤3 migraine days per month according to ichd-ii -criteria. exclusion criteria: * exclusion criteria were medication overuse headache (ichd-ii), previous whiplash or head trauma, other major physical or neurological diseases, depression, other mental illness, or being unable to understand and speak danish. the patients were tested for cervicogenic headache according to jull, et al 2007, and were excluded if the test was positive.
non-invasive brain stimulation by transcranial pulse stimulation as a coadjunctive treatment in alzheimer's disease

Conditions: Alzheimer Disease

Summary: this is a randomized, double-blind, placebo-controlled clinical trial; that will evaluate the effectiveness of the use of transcranial pulse stimulation in people living with alzheimer's disease, coming from the institute of psychiatry (ipq) of the hospital das clinicas, faculty of medicine, university of são paulo, and the institute of physical medicine and rehabilitation (imrea) at the hospital das clínicas, faculty of medicine, university of são paulo. participants will be classified according to the stage of alzheimer's disease, determined by a psychiatrist and neuropsychologists. a total of 50 volunteers will be randomized blindly. in addition to evaluating the clinical course and imaging examination, the use of scales that assess functional and cognitive disability will be used for the recruitment of volunteers. volunteers will be randomized into two study groups, and will receive the intervention that will consist of ten sessions, held twice a week. the storz neurolith™ equipment (storz medical, tagerwillen, switzerland) will be used to administer transcranial pulse stimulation.


Eligibility criteria:
inclusion criteria: * individuals who have alzheimer's disease will be selected; * are aged ≥50 years; * medical assistance provided by the psychiatry service at ipq; * who agree to participate after consent via the informed consent term . exclusion criteria: * make regular use of anticoagulants; * has skullcap failure, craniectomy without cranioplasty; * have a diagnosis of brain neoplasms or any type of nodule in the brain region; * have recent brain bleeds or a diagnosis of cerebral arteriovenous malformation; * be diagnosed with a type of dementia other than alzheimer's; * have mild cognitive impairment of the elderly (mci); * have clinical changes that put the test at risk, such as severe cardiorespiratory disorders; * has a severe cognitive disorder that makes it impossible to apply therapy or questionnaires; * it is clinically or socially impossible for the patient to attend imrea for applications twice a week during the study period; * those who disagree to participate after consent via the informed consent term .

Keywords: alzheimer disease transcranial magnetic stimulation extracorporeal shockwave therapy
safety and pharmacokinetics of sancuso and iv granisetron in patients aged 2 to 5 years

Conditions: Chemotherapy Induced Nausea and Vomiting

Summary: the purpose of this study is to determine the dosing strategy for adolescents aged 2 to 5 years.

this is an open-label, multi-center, cross-over study in male and female pediatric cancer patients, aged 2 to 5 years who are receiving at least 2 cycles of emetogenic chemotherapy requiring 5-ht3 antagonist treatment of up to 5 days duration. the study is designed to evaluate the safety and pk of transdermal granisteron (sancuso(r) patch) in a pediatric population (aged 2 to 5 years) using a population pk approach.

Eligibility criteria:
inclusion criteria: 1. 2 to 5 years of age inclusive at screening. 2. written parental (or appropriate legal representative) irb approved informed consent as appropriate. 3. confirmed malignancy. 4. scheduled to receive 2 or more cycles\* of emetogenic chemotherapy requiring 5-ht3 antagonist treatment. 5. scheduled to receive one or more consecutive days of 5-ht3 antagonist treatment, per cycle, as cinv prophylaxis. * the cycles of chemotherapy must be consecutive (i.e. one followed by the other) but do not have to be the first and second cycle of a line of treatment. exclusion criteria: 1. hypersensitivities, allergies or contraindications to study medications; intolerance of medical tape or sticking plaster. 2. clinical or laboratory signs and symptoms of significant cerebral, cardiovascular, respiratory, renal, hepatobiliary, pancreatic or infectious disease, which in the investigator's judgment may interfere with the study assessment or completion of the study. 3. patients with a known history or predisposition to cardiac conduction interval abnormalities, including qt syndrome, or known family history of long qt syndrome or taking medications that are known to prolong the qt interval. 4. patients scheduled to have routine surgery during the study duration. 5. patients with a life expectancy of \<6 months. 6. scarring or significant skin disease on both upper arms. 7. administration of other investigational drugs within 30 days preceding the screening visit, except for anticancer treatments. 8. any conditions associated with non-compliance.

Keywords: cinv
postoperative analgesia in laparoscopic abdominal surgery after exparel via tap or local infiltration

Conditions: Pain, Postoperative; Anesthesia, Local; Anesthesia; Functional; Anesthesia; Opioid Use

Summary: this study evaluates differences in how administering liposomal bupivacaine via two different methods affects postoperative pain control in laparoscopic abdominal surgery patients. half the participants will receive liposomal bupivacaine via a transverses abdominis plane block while the other half will receive liposomal bupivacaine via local infiltration.

liposomal bupivacaine is a newer formulation of a local anesthetic that is commonly used for local infiltration, peripheral nerve blocks, and neuraxial anesthesia. this new formulation allows the effects of bupivacaine to last up to 72 hours as it is slowly released from a liposome. it is fda approved for local infiltration and has recently been approved for interscalene blocks. a transversus abdominis plane block is a fascial plane block that is performed routinely for postoperative pain relief for some abdominal incisions. it is performed by placing local anesthetic between the internal oblique and transverses abdominis muscle planes where it will provide analgesia to several dermatomes of the abdomen in hopes of improving postoperative pain relief and reducing postoperative opioid requirement.

Eligibility criteria:
inclusion criteria: * patients scheduled for elective laparoscopic colorectal surgery at uwmc requiring inpatient stay exclusion criteria: * patients on chronic pain mediations equaling or exceeding \> 25 morphine daily equivalents * patients allergic to bupivacaine * patients with asa status iv, v, or vi * patients unable to consent * patients that are pregnant * patients that are incarcerated * patients receiving procedures in addition to laparoscopic colorectal procedure * patients on systemic anticoagulation precluding them from regional blocks