Kornimate/medical-research-clean huggingface dataset:
eating peanuts for health

Conditions: Obesity; Overweight; Hyperlipidemia

Summary: evidence is accumulating that peanut consumption confers health benefits, such as reduction of cardiovascular disease risk and possibly diabetes risk (jenkins et al., 2008; mattes et al., 2008). however, peanuts are a high fat, energy dense food and concerns about weight gain are widespread. although research indicates that other characteristics of peanuts offset these properties, and that peanuts may be incorporated into diets without posing a threat to weight gain (mattes et al., 2008), concern remains among policymakers, healthcare providers, and consumers. furthermore, worry exists that eating salted peanuts may elevate blood pressure and that eating honey-roasted peanuts make elevate blood sugar. these fears create substantial obstacles to increased peanut consumption. recommendations to increase peanut consumption may be made, but if they are not followed, there will be no impact on health. additional knowledge is needed on: (1) the acceptability of peanuts consumed on a chronic basis, (2) the chronic intake of moderate levels of peanuts and body weight, and 3) the effects of peanuts on blood pressure and blood sugar. the proposed research will examine the acceptability of long-term inclusion of a single form versus varied forms of peanuts in the diet. it is expected that responses will be varied among individuals with different personality characteristics (e.g., prefer sweet versus savory foods, hedonic versus non-hedonic eaters). a better understanding of how different segments of the population choose to include peanuts in their diet and how to optimize long-term consumption should provide insights for better marketing and improved health. furthermore, it is anticipated that eating salty peanuts will not raise blood pressure and that eating honey-roasted peanuts will not raise blood sugar. documenting this will add credibility to the evidence that peanuts do not cause weight gain, as well as reinforce recommendations to increase peanut consumption for their health benefits.


Eligibility criteria:
inclusion criteria: * between 18 and 50 years of age * weight stable (\< 3 kg weight change within last 3 months) * constant habitual activity patterns (no deviation \> 1x/wk at 30 min/session within last 3 months) * constant habitual diet patterns within last 3 months * willingness to eat all test foods (peanuts daily for 12 weeks) * no allergy to foods provided in the study (peanuts) * not a daily peanut or tree nut consumer * not planning to change use of medications known to influence appetite or metabolism * not diabetic or hypertensive * no history of gastrointestinal pathology * non-smoker for one year or more exclusion criteria: -

Keywords: obesity energy balance variety nut intake
evaluating human-machine interfaces in a robotic thumb orthosis

Conditions: Hemiplegic Stroke; Hemiplegic Cerebral Palsy

Summary: we plan to investigate whether the isolated orthosis for thumb actuation (iota) can effectively facilitate the ability of participants to perform a specific set of clinically relevant tasks conducted in a clinic setting.

many activities of daily living involve precision grasp and fine motor manipulation, such as putting toothpaste on a toothbrush or feeding oneself. however, children afflicted by stroke, cerebral palsy, or traumatic brain injury may lose the ability to actively (and accurately) control the thumb, and specifically abduct/adduct the carpometacarpal (cmc) joint and flex/extend the metacarpophalangeal (mcp) joint. we are testing the isolated orthosis for thumb actuation (iota), a device developed at the wyss institute at harvard university in collaboration with children's hospital boston, for assisting opposable thumb grasping tasks. the iota contains an adjustable brace fitted to the thumb and dorsum of the hand that is easy to put on and facilitates grasping motions through flexible cable-driven actuators that assist with cmc joint abduction and mcp joint extension. in this pilot study, we plan to investigate whether the iota can effectively facilitate the ability of participants to perform a specific set of clinically relevant tasks conducted in a clinic setting. the hypothesis for this work is that the iota will significantly improve the participant's performance on clinically relevant tasks.

Eligibility criteria:
inclusion criteria: * be between 7 - 16 years old * have a clinical diagnosis of hemiplegic cerebral palsy or hemiplegic stroke causing a thumb contracture affecting one hand * not have a diagnosis of dystonia * have completed at least a 6-week post-operative period following hand surgery (if applicable; self-reported) * be able to follow instructions (as determined by their attending occupational therapist) * not be allergic to nylon or lycra

Keywords: robot thumb orthosis hemiplegia hemiplegic stroke hemiplegic cerebral palsy stroke cerebral palsy grasp assistance
oral health status and diet history analysis among orphan house children from 10-14 years in cairo governorate.

Conditions: Gingival Disease Due to Bacteria

Summary: the purpose of study to determine oral health status and dietary habits among group of orphan children from 10-14 years in cairo governorate.

the study's investigators will record all data related to oral health status of orphan children from 10-14 years and their dietary habits to describe usual food intake and its variation over a long period of time . the ohi-s will also recorded which has 2 components the debris index and calculus index .

Eligibility criteria:
inclusion criteria: * egyptian children aged from 10-14 years * cooperative children exclusion criteria: * children with systemic disease , genetic disorders , or any disabilities
short term outcomes of robotic-assisted intersphincteric resection for low rectal cancer

Conditions: Rectal Cancer

Summary: this study compared robot-assisted total mesorectal excision to treat very low rectal cancer within 2 cm from the dentate line to avoid permanent colostomy. improves the quality of life with better defecation function, urinary function and sexual function.


Eligibility criteria:
inclusion criteria: 1. 18 years \< age \< 80 years 2. matching the diagnostic criteria; 3. tumor located 3 cm from anal verge 4. clinically diagnosed ct1-3n0-2 m0 lesions 5. tumor size of 4 cm or less 6. asa 1-3 scores; 7. ecog score is 0-1; 8. adequate preoperative sphincter function exclusion criteria: 1. requiring a mile's procedure 2. fecal incontinence; 3. previous abdominal surgery 4. severe mental disease. 5. intolerance of surgery for severe comorbidities 6. emergency operation due to complication 7. pregnant woman or lactating woman

Keywords: robotic intersphincteric resection rectal cancer pelvic autonomic nerve anal function
the combination effect of dexmedetomidine and morphine in postoperative patient-controlled analgesia

Conditions: Analgesia, Patient-Controlled; Analgesia, Postoperative

Summary: this study was designed to examine the analgesic and side effects of dexmedetomidine-morphine mixture for intravenous patient-controlled analgesia (pca).

patient-controlled analgesia (pca) is a widely accepted method to control postoperative pain. morphine is the commonest opioid for pca, however its side effects are troublesome. morphine-related side effects include pruritus, nausea, vomiting, constipation, urinary retention, respiratory depression, and sedation. many studies had been conducted to reduce the side effect of morphine. the current trend of reducing morphine side effect is direct combination of other drugs and morphine in pca. the advantages of this method are convenient in clinical use and preventive for side effects. dexmedetomidine is a highly selec¬tive α2-adrenergic receptor agonist that has been reported to cause sedative effects and reduce opioid requirements in the perioperative period. the main advantage of this drug is that it does not cause serious respiratory side effects. the analgesic, sedative/hypnotic and anxiolytic prop¬erties of dexmedetomidine make this drug potentially useful for postoperative sedation and analgesia. no previous study had investigated the effect of direct combination of dexmedetomidine and morphine in pca. the goal of this study is to investigate the combination effect of dexmedetomidine and morphine in postoperative patient-controlled analgesia.

Eligibility criteria:
inclusion criteria: 1. patients who sign informed consent to receive general anesthesia and postoperative analgesia with a pca device 2. age between 18-65 y/o 3. asa physical status i-iii 4. scheduled surgical procedures: gynecological surgery (vaginal or abdominal total hysterectomy), general surgery (gastrectomy, hepatectomy, colon cancer) , orthopedic (spinal fusion or total knee placement), or neurosurgical (cervical decompression) exclusion criteria: 1. patients with a definite diagnosis of chronic pain syndrome, psychiatric disorders, or drug abuse (include opioids, nsaids, sedatives, antidepressants). 2. use of sedatives, analgesics, antiemetics, or antipruritics within 24 hours before operation. 3. patients with definite diagnosis of esophageal reflux syndrome. 4. patients with the probability to be pregnant. 5. intraoperative fentanyl use \> 6 μg/kg. 6. patients with significant bradycardia (hr \< 60/min) and hypotension (sbp \< 90mmhg) after the surgery. 7. the duration of surgery is longer than 6 hours.
trigger point therapy versus manipulation correcting thoracic manipulable lesion

Conditions: Spinal Manipulable Lesion; Somatic Dysfunction

Summary: there will be no difference between trigger point therapy and spinal manipulation in correcting a spine joint dysfunction in the back


Eligibility criteria:
inclusion criteria: * mechanical thoracic back pain * age 18-64 * presence of at least one spinal manipulable lesion * presence of a trigger point associated with the spinal manipulable lesion * able to lie prone on a treatment table for 15 minutes exclusion criteria: * absolute contraindications to spinal manipulation * specific thoracic back pain * bleeding diathesis, use of anticoagulants, long-term corticosteroid use * involved in litigation for thoracic back pain * inability to read or write english fluently * treatment with manipulation or myofascial therapy within past three days
user testing and feedback for a mobile health program for postpartum women: a pilot study

Conditions: Gestational Diabetes Mellitus; Preeclampsia; Gestational Hypertension; Pre-term Delivery; Delivery of Small for Gestational Age (SGA) Baby

Summary: refine content and delivery of the mhealth delivered lifestyle intervention program through iterative testing with small groups of users who provide feedback through on-line asynchronous focus groups.

participants are asked to: * use mobile app for 4 weeks * receive support from the lifestyle coach * provide weekly and ongoing feedback via an online asynchronous user group platform on usability, navigability, acceptability, and satisfaction.

Eligibility criteria:
inclusion criteria: * age 18-45 * body mass index (bmi): 25 - 45 kg/m2 * positive history of one or more of the following complications in most recent singleton pregnancy: 1. gestational diabetes mellitus 2. preeclampsia (high blood pressure and proteinuria diagnosed after 20 weeks gestation) 3. gestational hypertension (new hypertension diagnosed after 20 weeks without proteinuria) 4. pre-term delivery (32-37 weeks) 5. small for gestational age (\<10th percentile for gestational age) * able to communicate in english * access to and be willing to use a wi-fi enabled iphone or ipod * access to a computer with internet access * capable of providing informed consent * between 4 weeks and 24 weeks after delivery exclusion criteria: * personal history of type 1 or 2 diabetes * personal history of breast cancer or any other type of cancer other than a basal cell skin cancer; * personal history of major chronic illness including cardiovascular disease (coronary artery disease, congestive heart failure, valvular heart disease, stroke, transient ischemic attack, or intermittent claudication), kidney disease, liver disease, venous or arterial thromboembolic disease, adrenal insufficiency, depression requiring hospitalization within the past 6 months, or non-pregnancy related illness requiring overnight hospitalization in the past 6 months; * underlying disease/treatment that might interfere with participation in/completion of the study (e.g. significant gastrointestinal conditions, major psychiatric disorders, and others at the discretion of the study clinician)

Keywords: mobile application postpartum weight loss
study on the relationship between physical constitution and diseases

Conditions: Chronic Diseases

Summary: physical constitution is an important factor for the development and outcome of diseases according to the theory in traditional chinese medicine. the purpose of the study is to find the correlation between physical constitution and clinical characteristics (age, sex, symptoms, physical signs, life style, laboratory results and image findings) through the questionnaire and results of health examination.

it is difficult to predict the process or outcome of disease for individuals who expose to the same pathogen or condition. but according to the traditional chinese medicine, physical constitution is an important factor for disease pattern, severity and response to the treatment. so it is paid more and more attention in western medicine to study the variation of individualized susceptibility to diseases. there have been some researches to investigate the relationship between physical constitution and disease pattern. before further studies, we need to obtain more information about physical constitution and clinical characteristics. therefore we design a comprehensive questionnaire to survey the types of physical constitution. and we plan to collect the data from health reports of candidates after their medical tests at health examination center in national taiwan university hospital yu-lin branch. we focus on the relationship between clinical characteristics (age, sex, symptoms, physical signs, laboratory results and image findings) of western medicine and the physical constitutional types of chinese medicine. then we will try to find the correlation and significance between them. the study will conclude the constitutional characteristics in general population of taiwan and the distribution tendency of physical constitution for the common diseases. the result can serve as a stepping stone for integration of the traditional chinese medicine and western medicine.

Eligibility criteria:
inclusion criteria: * candidates with healthy report on health exam exclusion criteria: * acute infection * chronic disease with acute exacerbation * unstable disease status or medication

Keywords: physical constitution disease pattern laboratory data integrative chinese medicine and western medicine
influence of an anterior latarjet-type abutment operation on scapular dyskinesia and the muscular stabilization mechanisms of the scapula (dyscaplat)

Conditions: Latarjet; Scapular Dyskinesis

Summary: the aim of this study is to assess the influence of anterior abutment surgery using the latarjet method on the kinematics of the scapula. the sub-objectives will be to show that latarjet-type surgery does not lead to scapular dyskinesia and modification of muscle activity compared to a control group that has not undergone an operation.


Eligibility criteria:
inclusion criteria: * patient group: * male between 18 and 40 years-old * practice a regular sports activity before the injury (s) requiring surgery * present the clinical criteria leading to anterior abutment surgery using the latarjet method * surgery performed by surgeons from the jean-mermoz private hospital (69008 lyon) * have followed a post-surgery self-rehabilitation program control group: * male between 18 and 40 years-old * practice a regular sports activity both group: opatient having signed an informed consent o subject affiliated or beneficiary of a social security scheme exclusion criteria: patient group: * have another shoulder pathology on the side of the operated limb or on the contralateral side * present a constitutional hyper laxity * have stiffness or recurrence of dislocation of the shoulder post-surgery * have a body mass index greater than 30 kg / m² (to ensure sufficient accuracy to measure the movements of the scapula) * wear a pacemaker or any other metal device (e.g. patch with metal material) * present a contraindication to the use of measuring devices (intolerance to a weak electromagnetic field) control group: * present during the study or have presented in the past any musculoskeletal pathology in the right or left shoulder (wosi or worc score greater than 250). * have a body mass index greater than 30 kg / m² (to ensure sufficient accuracy to measure the movements of the scapula) * wear a pacemaker or any other metal device (e.g. patch with metal material) * present a contraindication to the use of measuring devices (intolerance to a weak electromagnetic field) both group : o protected subject: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision
trauma-focused group music and imagery with traumatized women

Conditions: Stress Disorders, Post-Traumatic

Summary: this study is a mixed methods randomized controlled trial (wait list control), that investigates the effects of group music and imagery (grpmi) therapy in the treatment of women suffering from post traumatic stress disorder (ptsd) or complex ptsd. the aim is to detect if the intervention has an effect on ptsd symptoms, dissociation, quality of life, and the capability of regulating the autonomic nervous system (ans).

participants are adult women suffering from ptsd or complex ptsd (n=56) that are randomized to three months of weekly (12) sessions of trauma modified grpmi therapy or no treatment for an equal amount of time (wait list control). primary outcome is pre, post and 3 months follow-up measures of ptsd checklist 5 (pcl-5). secondary outcome is pre, post and 3 months follow-up measures of dissociative experience scale (des), positive state of mind scale (psom-s), hopkins symptoms checklist (hscl-25), somatoform dissociation questionnaire (sdq-5), and reactivity and recovery of different physiological measures related to arousal regulation ability in a script driven imagery setting.

Eligibility criteria:
inclusion criteria: * be suffering from ptsd/cptsd, * be sufficiently stabilised to tolerate being exposed to trauma treatment and listen to other subjects' stories, * be able to speak good enough swedish to express themselves without an interpreter, * have an interest in working with their problems using artistic languages, * have an ability to work with symbolism and inner images. exclusion criteria: * difficulties in understanding or making themselves understood in swedish, * severe personality disorder or neuropsychiatric disorder, * ongoing alcohol or drug abuse, * psychotic disorder, * suicidality, * serious ongoing medical condition, * serious psychosocial problems.
a study to compare the efficacy and safety of oral azacitidine plus best supportive care versus best supportive care as maintenance therapy in japanese participants with acute myeloid leukemia (aml) in complete remission

Conditions: Acute Myeloid Leukemia

Summary: the purpose of this study is to assess the efficacy and safety of oral azacitidine plus best supportive care versus best supportive care as maintenance therapy in a cohort of japanese participants ≥ 55 years of age with acute myeloid leukemia (aml) and in complete remission/complete remission with incomplete blood count recovery after conventional induction chemotherapy with or without consolidation chemotherapy.


Eligibility criteria:
inclusion criteria: * ≥ 55 years of age inclusive at the time of signing the informed consent * newly diagnosed, histologically confirmed de novo acute myeloid leukemia (aml) or aml secondary to prior myelodysplastic syndrome (mds) or chronic myelomonocytic leukemia (cmml) * should have undergone induction therapy with intensive chemotherapy with or without consolidation therapy as recommended in appropriate guideline(s) or equivalent regimen according to institutional standard: having achieved first complete remission (cr)/complete remission with incomplete blood count recovery (cri) status within 4 months prior to starting study therapy exclusion criteria: * suspected or proven acute promyelocytic leukemia; or aml with previous hematologic disorder such as chronic myeloid leukemia or myeloproliferative neoplasms, excluding mds and cmml * prior bone marrow or stem cell transplantation * received therapy with hypomethylating agents for mds and went on to develop aml within four months of discontinuing the therapy with hypomethylating agents * have achieved cr/cri following therapy with hypomethylating agents other protocol-defined inclusion/exclusion criteria apply
relationship between normal-weight central obesity and obstructive sleep apnea

Conditions: Sleep Disorder; Body Fat Distribution

Summary: comparison of the prevalence of obstructive sleep apnea (osa), measured by polysomnography in normal weight patients with central obesity by body mass index (bmi) and waist hip ratio (whr), with normal weight patients without central obesity by bmi and whr. evaluation of arterial stiffness and vascular age in normal weight patients with central obesity and in normal weight patients without central obesity. determination of the exercise response characteristics in osa patients.

body composition (the distribution of adipose tissue) appears to be a risk factor for the prevalence of obstructive form of sleep apnea. the investigators expect a higher prevalence of this serious sleep pathology in normal weight patients with central obesity than in normal weight patient without central obesity. in normal weight patients with central obesity also endothelial dysfunctions, abnormal exercise response to dynamic load and abnormal circadian patterns of blood pressure and heart rate can be expected. there are theoretical assumptions for this hypothesis but relevant studies on sufficiently large samples of patients have not been done. the investigators will also compare the lipid profile in normal weight patients with central obesity with those of normal weight patients without central obesity.

Eligibility criteria:
inclusion criteria central obesity group: * bmi 18.5 - 24.9 kg/m2 for both men and women * whr more than 0.9 for men and 0.85 for women * no history of myocardial infarction, stroke, atrial fibrillation, previous diagnosis of osa or its treatment. inclusion criteria without central obesity group: * bmi 18.5 - 24.9 kg/m2 for men and women * whr selected from the lowest tertile of whr distribution for both men and women exclusion criteria: * acute infection * known diagnosis of chronic renal or cardiac failure * taking drugs that affect sleep (stimulants, hypnotics, antidepressants, antipsychotics, anxiolytics, antihistamines, corticosteroids, theophylline, anti-parkinsonic drugs, anticonvulsants, morphine-type analgetics)

Keywords: obstructive sleep apnea, normal weight obesity