Kornimate/medical-research-clean huggingface dataset:
epidemiological data on pain

Conditions: Orthopedic Disorder; Thoracic; Gynecological; Surgery (Previous), Causing Obstructed Labor, Affecting Fetus; Pain

Summary: the algobases project is an observational epidemiological study of pain through the collection of pain evaluation questionnaires and information with the aim of creating a descriptive "pain" evaluation in all patients who need to benefit from orthopedic, thoracic or gynecological surgery. the painful symptomatology will thus be evaluated in all its dimensions (demographic data, physical, psychological, socio-cultural components) and linked to the pathology justifying the specialized care. it is planned to collect the same data at each subsequent event in order to allow the determination of predictive factors, pain trajectories according to the type of surgery, and the profile of subjects at risk of acute or chronic postoperative pain.


Eligibility criteria:
inclusion criteria: * patient over 17 years old patient needing orthopedic surgery patient needing gynecological surgery patient needing thoracic surgery patient who has given written consent to participate in the trial. socially insured patient patient willing to comply with all study procedures and study duration exclusion criteria: * age under 18 years old * non-communicating patient * patient does not understand french * patient without social protection * patient refusing to participate

Keywords: pain, perioperative pain epidemiology predictive factors
a comparison of two injection locations in obese patients having lower leg/foot surgery

Conditions: Strain of Muscle and/or Tendon of Lower Leg; Fracture of Lower Leg; Crushing Injury of Lower Leg; Fracture Malunion - Ankle and/ or Foot; Complete Tear, Ankle and/or Foot Ligament; Pathological Fracture - Ankle and/or Foot; Loose Body in Joint of Ankle and/or Foot

Summary: one technique for the nerve block involves injecting the numbing medicine where the nerve is together (higher up in the back of the thigh). the other technique involves injecting the numbing medicine where the nerve splits into two parts. by injecting numbing medication around the nerve(s), there will be less pain after the procedure. it is thought that the numbing medicine will be easier to inject in the group that the nerves are split. it is expected that subjects may need less pain medication and have lower pain ratings in this group too.

the purpose of this study is to compare two different techniques for placement of nerve blocks for your foot or ankle procedure. a nerve block involves injecting numbing medications around a nerve to decrease pain after surgery. an ultrasound machine is often used to help see the nerve before injecting the numbing medicine. when an ultrasound machine is used during a block it is called an ultrasound-guided block. many studies of ultrasound-guided nerve blocks have involved mostly thin patients, especially from foreign countries. this study is different because the investigators are looking at patients living in america with a body mass index (a measure of the amount of body fat a person has) of more than 35. the sciatic nerve is a large nerve that provides most of the feeling and all of the movement to the foot and ankle. the nerve travels under the back of the leg, and splits into two smaller nerves slightly above the knee.

Eligibility criteria:
inclusion criteria: * patients ≥ 18 years of age undergoing unilateral foot and/or ankle surgery * severe or morbid obesity, defined as a bmi of 35-39 or ≥ 40, respectively * asa status i-iv * ability to understand and provide informed consent exclusion criteria: * true allergy, not sensitivity, to any of the following substances: local anesthetics midazolam fentanyl hydromorphone propofol * pregnancy * evidence of infection at or near the proposed needle insertion site * unstable or undetermined neurologic disease of the lower extremity * chronic pain patients * patient refusal or inability to provide informed consent

Keywords: obese regional anesthesia anesthesia anesthesiology surgery foot foot surgery ankle ankle surgery orthopedics orthopedic surgery sports medicine sports medicine surgery ochsner hospital ochsner clinic new orleans louisiana jefferson soberon
an observational study of valcyte (valganciclovir) in d+/r- liver transplant recipients

Conditions: Cytomegalovirus Infections

Summary: this retrospective review will evaluate the efficacy of valcyte (valganciclovir) in preventing cytomegalovirus (cmv) disease in d+/r- liver transplant recipients. data from eligible patients will be collected for the 6 months following transplantation.


Eligibility criteria:
inclusion criteria: * liver transplant recipients, \>/= 16 years of age * transplantation between january 2004 and june 2009 * cmv seronegative recipient (r-) who received a liver transplant from a seropositive donor (d+) * valganciclovir therapy for at least 70 days beginning within 10 days post transplantation * assessment of cmv disease status within the first 6 months post transplantation exclusion criteria: * none
enhancing extinction learning in post traumatic stress disorder (ptsd)

Conditions: Chronic Posttraumatic Stress Disorder

Summary: posttraumatic stress disorder (ptsd) is a condition that involves intense memories of a traumatic event and intense, persistent feelings of anxiety. there are several effective therapies for ptsd, but they are often time consuming. the investigators want to see if the investigators can shorten treatment time while keeping therapy effective by adding a medication called methylene blue, usp, taken orally as a pill, to the therapy. the specific aims are: 1) to see whether medication plus psychotherapy improves ptsd symptoms more than placebo plus psychotherapy or a waitlist; 2) to examine the long-term outcome of those receiving medication plus psychotherapy 1 and 3 months after treatment has ended; 3) to examine whether medication plus psychotherapy helps with depression, trauma-related cognitions, and functioning.

the psychotherapy the investigators are offering in this study is a type of cognitive behavioral therapy called imaginal exposure. in imaginal exposure, the investigators encourage the client to approach the memory of the trauma by recounting the trauma story to the therapist and discussing his or her reactions to the memory.

Eligibility criteria:
inclusion criteria: 1. current primary ptsd diagnosis based on dsm-iv criteria, with a minimum duration of 12 weeks since the traumatic event. 2. between the age of 18 and 65. exclusion criteria: 1. current diagnosis of schizophrenia, delusional disorder, or organic mental disorder as defined by the dsm-iv. 2. current diagnosis of bipolar disorder, depression with psychotic features, or depression severe enough to require immediate psychiatric treatment (i.e., serious suicide risk with intent and plan). 3. current diagnosis of alcohol or substance dependence within the 3 previous months. 4. unwilling or unable to discontinue current trauma-focused psychotherapy or psychotropic medication (at least 1 month medication free). 5. ongoing intimate relationship with the perpetrator (in assault-related ptsd cases). 6. unstable cardiovascular, autoimmune, endocrine, neurological, renal, hepatic, retinal, gastrointestinal, or hematological disorder or current seizure disorder. 7. pregnant or nursing females; females of childbearing potential who are unwilling or unable to use an acceptable method of contraception for the duration of active treatment. 8. a history of hypersensitivity or allergy to mb. 9. any condition possibly affecting drug absorption (e.g., gastrectomy). 10. glucose-6-phosphate dehydrogenase deficiency. 11. other severe acute or chronic medical or psychiatric condition or laboratory abnormality that, in the judgment of the medical directors, would make the participant inappropriate for entry.
omics in valvular disease

Conditions: Stenosis, Aortic

Summary: the aim of our study is to investigate the effects of impaired left ventricular remodeling on the short- and long-term prognosis in as partecipants undergoing extracorporeal circulation during valve repair surgery and in partecipants undergoing implantation transcatheter. for the achievement of these purposes, markers obtained from will be considered cardiovascular imaging methods, such as color doppler echocardiography and isolated biomarkers from peripheral blood and heart tissue.

participation in this study includes, following enrollment, a visit of follow up (6/12 months) on the occasion of a concomitant medical check-up scheduled according to normal clinical practice. during these visits venous and contextual blood samples will be taken echocardiographic examination for re-evaluation of ejection fraction, as per normal practice clinic. the only variant will be the withdrawal of an additional aliquot of blood during the sampling standard blood. all enrolled partecipants will undergo the optimal medical treatment provided by current and more recent guidelines for the treatment of heart valve disease. joining this study will not result any modification of the current therapy, which will be established by the attending physician according to the correct one clinical practice.

Eligibility criteria:
inclusion criteria: -30 patients with a diagnosis of severe aortic stenosis and preserved ejection fraction to echocardiographic evaluation exclusion criteria: * inflammatory; * infectious diseases; * neoplasms; * ailments immunological or haematological; * treatment with anti-inflammatory drugs except aspirin a low dose (75-160 mg); * age \> 85 years; * advanced chronic kidney disease with filtrate glomerular heart rate (egfr) estimated by mdrd equation \<30 ml/min./1.73 m2.

Keywords: transcatheter aortic valve replacement surgical aortic valve replacement
optical frequency domain imaging (ofdi) assessment in radiofrequency ablation

Conditions: Barrett's Esophagus

Summary: the goal of this research is to conduct a pilot clinical study to evaluate the potential use of esophageal optical frequency domain imaging (ofdi) for assessing the success and degree of injury associated with therapeutic radiofrequency ablation techniques.

this is a single center pilot study conducted in 30 patients scheduled for therapeutic intervention. as the purpose of the study is to assess the response of the esophagus to radio frequency (rf) ablation, and the degree of residual barrett's esophagus (be) remaining following treatment, ofdi imaging of study participants will occur prior to the scheduled barrx rf treatment, and at the standard 3 and 6 month follow-up visits. following initial visual surveillance of the esophagus, the study experimental procedure will begin. imaging will be performed with the ofdi system in 4 longitudinal (\~5cm) volumetric segments that are spaced equally circumferentially along the esophagus in a similar fashion to the standard 4-quadrant biopsy protocol. each of the 4 ofdi imaging segments will be acquired in less than 1 minute.

Eligibility criteria:
inclusion criteria: * patients with a diagnosis of barrett's esophagus * patients undergoing an esophagogastroduodenoscopy (egd) * patients scheduled for treatment with rf ablation or patients that have had previous barrx rf ablation * patients must be over the age of 18 * patient must be able to give informed consent * women with child bearing potential must have a negative pregnancy test prior to procedure exclusion criteria: * patients on oral anticoagulation medications * patients with a history of hemostasis disorders * patients that are pregnant * patients with esophageal strictures

Keywords: barrett's esophagus esophagus oct imaging radiofrequency ablation barrx
evaluating personalized therapeutics clinic (ptc) on drug-drug interactions and drug-gene interactions

Conditions: Cancer; Advanced Cancer; Advanced Solid Tumor; Mental Health Issue; Behavior Disorders

Summary: the purpose of this study is to determine whether a consultation with a personalized therapeutics clinic, or ptc, will help participants lower the risk for side effects (drug-drug interactions and drug-gene interactions) when taking many medications and help providers improve prescribing decisions for participants. a ptc is a clinical that will test your genes to gather information about your health that may help guide prescribing advice and offer you new information about your prescriptions. doctors leading this study will look for variations (differences) in your genes that may suggest that you are at greater risk of having side effects or a greater chance of benefiting from certain medications. individuals in this study will participate for roughly 9 months.


Eligibility criteria:
inclusion criteria: 1. adult participants cared for by a participating provider at university of chicago medical center. 2. participants must be at least 18 years of age. 3. participants prescribed 5 or medication medications and taking a perpetrator drug or a drug with actionable pharmacogenomic information. exclusion criteria for participants 1. participants who have undergone, or are being actively considered for, liver or kidney transplantation. 2. participation in another pharmacogenomic study. 3. participants who have previously received genotyping from another source. 4. inability to understand and give informed consent to participate. inclusion of women, minorities, and other underrepresented populations individuals of all races and ethnic groups and genders are eligible for this trial.

Keywords: tumor advanced cancer advanced solid tumor cancer medication prescriptions inhibitor drug inducer drug
retained lens fragments after phacoemulsification

Conditions: Cataract

Summary: the purpose of this study is to investigate postoperative events in patients noted to have retained nuclear fragments in the anterior vitreous during routine phacoemulsification and in those who did not.

in this study, we investigate whether presence of retained nuclear fragments in the anterior vitreous noted during uncomplicated cataract surgery is associated with higher incidence of postoperative adverse events. we will be assessing events including cystoid macular edema, iritis, elevated intraocular pressure, and retinal detachment.

Eligibility criteria:
inclusion criteria: * routine cataract surgery with phacoemulsification exclusion criteria: * pre-existing macular edema * active uveitis * intraocular exclusion surgeries * significant ocular trauma * evidence of phacodonesis or zonular weakness .

Keywords: retained nuclear lens fragments phacoemulsification cataract surgery
esmolol for myocardial protection in hypertrophic obstructive cardiomyopathy

Conditions: Hypertrophic Obstructive Cardiomyopathy

Summary: perioperative blockage of beta-adrenoreceptors is widely used in cardiac and non-cardiac surgery to reduce the rate of cardiovascular complications. several randomized-controlled studies and meta-analysis showed that esmolol reduces the incidence of myocardial ischemia and arrhythmias in cardiac surgery as well as enhances postoperative cardiac performance. no studies assessed the influence of esmolol in patients with hypertrophic obstructive cardiomyopathy undergoing cardiac surgery.


Eligibility criteria:
inclusion criteria: * age \> 18 years * signed informed consent * patient with hypertrophic obstructive cardiomyopathy undergoing surgery under cardiopulmonary bypass exclusion criteria: * history of adverse effects on esmolol * urgent/emergent surgery * administration of esmolol in 30 days before randomization * participation in other randomized trial during same hospitalization
effects of high-intensity interval training on depressive symptoms in hong kong older adults

Conditions: Depressive Symptoms

Summary: depression in later life is a common health problem in aging societies. it is associated with poor quality of life, and increased risks of morbidity and mortality. people with severe depression may develop serious psychotic symptoms (e.g., delusions) and have higher mortality and disability than those with mild and moderate depression. traditional moderate-intensity continuous training (mict) (e.g., baduanjin qigong) has proved to be effective in preventing and alleviating depressive symptoms among older adults. however, older adults with mental illnesses have poorer engagement and compliance with mict programs. in recent years, as a novel type of exercise, high-intensity interval training (hiit), which includes repeated bouts of high-intensity effort followed by varied recovery times, appears to be a promising approach for overcoming limitations in traditional mict programs. considering there is little evidence of hiit benefits related to older adults with depression, the current study aims to evaluate the effectiveness of a 16-week hiit intervention on depressive symptoms and other health-related outcomes among hong kong chinese older adults.

the study will be a cluster randomized controlled trial (crct) with three groups and three times repeated measures. data will be collected in a pretest, post-test, and three months after the intervention. the eligible community elderly centers will be randomly distributed into one of three groups in a ratio of 1:1:1. the participants recruited and meeting the screening criteria will receive a 16-week hiit intervention or baduanjin exercise or recreation workshop. the intervention effects will be evaluated on depressive symptoms, concentration of salivary cortisol, sleep quality, quality of life, and physical fitness.

Eligibility criteria:
inclusion criteria: * 60 to 74 years at the start date of the project * chinese version of geriatric depression scale (gds-c) scoring 5-11 (i.e., mild to moderate level of depressive symptoms) * passing the par-q plus screening or with the physician's approval for readiness to participate in high-intensity exercise * above the average level of 2-mins stepping showing competent aerobic fitness * no restriction on physical mobility * no cognitive impairment, as determined by the chinese version of the mini-mental status examination (i.e., score \< 24) * no previous substantial experiences in practicing hiit or baduanjin qigong. the written informed consent form will be collected from each participant exclusion criteria: * severe chronic disease restricting high-intensity exercise * having cognition impairment regarded by specialists

Keywords: depressive symptoms older adults high-intensity interval training baduanjin qigong
effect of vericiguat on endpoint events in acute coronary syndrome( acs）patients with ejection fraction <45%

Conditions: Acute Coronary Syndrome; Heart Failure With Reduced Ejection Fraction

Summary: investigators evaluate whether differences exsit in acute coronary syndrome（acs） patients with ejection \<45% between participants who take vericiguat regularly and those who donot.

vericiguat, a novel soluble guanylate cyclase stimulator, reduced the incidence of cardiovascular death or hospitalization for hf in a population of high-risk patients with heart failure with reduced ejection fraction （hfref ）who had recently been hospitalized or received intravenous diuretic therapy.given the increasing incidence of patients with acs and its challenges posing to life，investigators intend to conduct a prospective observational study. investigators choose several meaningful endpoints including the time of cardiovascular death or heart failure（hf) hospitalization、inflammatory markers、the value of n-terminal pro-b-type natriuretic peptide(nt-probnp)、results of echocardiogram and life quality score.by collecting these datas and work on a group of analysis ，investigators evaluate whether differences exsit in acs patients with ejection \<45% between participants who take vericiguat regularly and those who donot.

Eligibility criteria:
inclusion criteria: * 1.provide written informed consent for the trial. * 2.has acute coronary syndrome (unstable angina, non-st elevation myocardial infarction \[nstemi\], or st elevation myocardial infarction \[stemi\]) or coronary revascularization (coronary artery bypass grafting \[cabg\] or percutaneous coronary intervention \[pci\]). * 3.ejection fraction \<45%. * 4.be male or female, aged greater than18 and less than 90 on the day of signing informed consent. exclusion criteria. * 1.sbp\<100mmhg. * 2.is pregnant or breastfeeding or plans to become pregnant or to breastfeed during the course of the trial. * 3.has severe hepatic insufficiency or renal insufficiency. * 4.has malignancy or other non-cardiac condition limiting life expectancy to \<1 years.
immunogenicity and safety of two lots of nbp608 compared to zostavax in healthy adult aged 50 and over

Conditions: Herpes Zoster

Summary: this study assesses non-inferiority by comparing gmr(geometric mean ratio) of nbp608 to zostavax which are evaluated by gpelisa (glycoprotein enzyme linked immunosorbent assay). total of 646 healthy subjects aged 50 and over are enrolled, and each subject is administered with single dose of vaccine which is randomly assigned.

this is a multi-center, randomized, double blinded, parallel-group study to assess the immunogenicity and safety of nbp608 compared to zostavax which are indicated for the prevention of herpes zoster. total of 646 healthy subjects aged 50 and over are enrolled, and each subject is administered with single dose of vaccine which is randomly assigned to low, high potency of nbp608 group and zostavax group in 1:1:2 ratio. stratified randomization for age group is used to achieve the balance of treatment assignment within age strata. total of six visits are scheduled including two visits via telephone contact. blood sampling is conducted for immunogenicity assessment before and 6 weeks, 52 weeks after vaccination at visit 2, visit 4, visit 6 respectively. safety is monitored 1 week, 6 weeks, 26 weeks and 52 weeks after vaccination through visit 3\*, visit 4, visit 5\*, visit 6. (\* telephone contact)

Eligibility criteria:
inclusion criteria: * healthy adult over aged 50 years * menopause females or females who are confirmed to be negative in a preganacy test on the day of screening and agree to practice birth control for 6 weeks after signing informed concent exclusion criteria: * those with hypersensitivity to any component of ip(investigational product), such as gelatin * those with a history of hypersensitivity to vaccination, such as guillain-barre syndrome * those who have previously received herpes zoster vaccine * those who have a history of herpes zoster * those with congenital or acquired immunodeficiency * those with active untreated tuberculosis * those who have received blood products or immunoglobulin within 3 months prior to screening visit * those who have received other ips(investigational products) in another clinical study witin 4 weeks prior to ip vaccination in this study

Keywords: herpes zoster vaccine prevention of herpes zoster