Kornimate/medical-research-clean huggingface dataset:
study on the effect of sound therapy on chronic primary tinnitus

Conditions: Tinnitus

Summary: this study is to compare the effect of cochleural alternating acoustic beam therapy(caabt) and tinnitus masking therapy(tmt) on chronic primary tinnitus.half of participants will receive caabt, while the other half will receive tmt.

the patients with tinnitus will be collected with medical history, ear examination ,auditory function test and questionnaire survey.100 cases of chronic primary tinnitus will be selected as the research object.this study will be developed in the form of a blind randomized clinical trial.the study subjects will be divided into 2 groups by randomized method, with 50 cases in each group. psychological acoustic test, resting-state function magnetic resonance imaging（rs-fmri) will be conducted.for 6 months, the patients will be treated with cochleural alternating acoustic beam therapy（caabt）and tinnitus masking therapy（tmt） respectively, followed by questionnaire survey, psychological acoustics test and rs-fmri. the thi,vas score, rs-fmri reho value and low-frequency wave amplitude (alff) before and after the treatment will be compared. for those cases with poor results, the exchanged treatment will be performed for 6 months, followed by questionnaire survey, psychoacoustic test, rs-fmri, and comparison of thi, vas score, reho value and alff before and after treatment.all cases will be followed up for 1 year, and questionnaire survey will be conducted again.

Eligibility criteria:
inclusion criteria: * ages between 18-75 years * tinnitus undergone for more than 6 months * continuous attack, single tone dominated, annoying tinnitus * able to cooperate with auditory function test and psychoacoustic test * the main tinnitus frequency is from 125hz to 8000hz * willing to use the equipment daily during the test * willing and able to follow up regularly * ability to read and write chinese, able to understand and complete questionnaires exclusion criteria: * secondary tinnitus * pure tone audiometry shows conduction deafness or mixed deafness * tinnitus main frequency threshold \>60db * receiving treatment for other tinnitus * mri contraindications * feeling uncomfortable with the treatment equipment or not being accepted
prevelance of keratoconus

Conditions: Keratoconus

Summary: keratoconus is a degenerative disease entity characterized by conical shape ectasia of the cornea. progressive conical deformation of the cornea leads to substantial astigmatism. patients who are at an advanced stage of ectasia are often led to corneal transplant or other treatments, which essentially aim at correcting the refractive error and not in treating the ectasia. the top of the protruding cone that corneal configuration may be close to the visual axis or below and nasal of that. the disease manifests during adolescence, followed by slow progressive course, although it is possible to stabilize anytime. in 85% of cases both eyes are affected, but the severity of the attack can present significant asymmetry.

often in keratoconus a positive family history is present. prevelance of keratoconus varies greatly worldwide.the reported prevalence of keratoconus varies widely depending upon the geographic location, diagnostic criteria used, and the cohort of patients selected. environmental factors may contribute to the wide variation in prevalence. the middle east have higher prevalence than locations with cooler climates and less sunshine

Eligibility criteria:
inclusion criteria: 1. persons attending refractive surgery centers in asssiut. 2. patients found to have keratoconus are included , based on history , clinical examination and corneal topography exclusion criteria : 1. patients not attending those refractive surgery centers. 2. patients attending these centers but not diagnosed to be keratoconus . 3. pregnancy or breastfeeding
unusual clinical findings of herpes esophagitis

Conditions: Herpes Esophagitis; Vocal Fold Palsy

Summary: herpes esophagitis presents a clinical diagnostic challenge. the investigators report the first case of herpes esophagitis presenting as vocal fold palsy in an immunocompetent host. the investigators case highlights the importance of performing a detailed laryngoscopic examination in any patient with prolonged husky voice.


Eligibility criteria:
inclusion criteria: * patient of herpes esophagitis with vocal palsy presentation exclusion criteria: * patient of herpes esophagitis without vocal palsy presentation

Keywords: herpes esophagitis dysphagia vocal fold palsy immunocompetent husky voice
superficial parasternal intercostal plane block in cardiac surgery trial

Conditions: Post-operative Pain; Post-operative Delirium; Post-cardiac Surgery; Chronic Pain; Opioid Use Disorder; Anesthesia, Local

Summary: the goal of this clinical trial is to assess whether the use of intermittent superficial parasternal intercostal plane blocks reduces opioid usage in patients undergoing cardiac surgery with median sternotomy. participants randomized to the intervention group will receive the blocks with 0.2% ropivacaine administered via catheters placed in the superficial parasternal intercostal plane bilaterally under ultrasound guidance. researchers will compare this group with a control group given 0.9% saline through similarly placed catheters. the primary outcome will be cumulative postoperative opioid use (measured as milligram morphine equivalent (mme)) up to 72 hours following catheter insertion.

this trial is comparing the use of 0.2% ropivacaine and 0.9% saline through a parasternal intercostal plane block and to measure whether there are any tangible changes in: 1. cumulative postoperative opioid use from catheter insertion until hospital discharge - measured as milligram morphine equivalent (mme) 2. median pain score - measured at rest and with coughing using a standardized numerical rating scale - over 72 hours post catheter insertion 3. delirium - assessed twice daily using institutional scores up to 72 hours following catheter insertion.

Eligibility criteria:
inclusion criteria: * adult patients undergoing cardiac surgery via median sternotomy exclusion criteria: * redo sternotomy, or cardiac surgery performed through non-sternotomy approaches (minimally invasive procedures, thoracotomies, mini-sternotomy, hemi-sternotomy, etc.) * emergency procedures (surgery within 2 hours) * clinical instability which in the judgement of the investigator precludes enrollment or participation in the study * weight \< 50kg * active systemic bacterial infection including infective endocarditis or pre-existing sternal infections * surgery for infective endocarditis * pregnancy or nursing * chronic opioid/narcotic use \> 6 weeks, active use of illicit drugs, long-term opioid exposure or chronic pain disorder/syndromes * allergies to amide anesthetic agents or any components of study interventions * inability to comply with, or participate in, protocol (i.e. cognitive impairment/altered mental status/neurological deficit or disorder, inability to provide informed consent, inability to complete pain rating scales, etc.) * receipt of an investigational drug or device within past 7 days
a study to evaluate the safety, tolerability and efficacy of rz-001 in combination with valganciclovir (vgcv) and atezolizumab/bevacizumab in subjects with hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma (HCC)

Summary: this study is to evaluate the safety, tolerability, efficacy and immunogenicity of rz-001 in combination with valganciclovir (vgcv) and atezolizumab/bevacizumab when given to subjects with human telomerase reverse transcriptase (htert)-positive hcc.

15 subjects will be enrolled in each of the 3 cohorts. once enrollment of the first 3 of 15 subjects is completed, safety and efficacy review committee (serc) meeting involving the study investigators and the sponsor's clinical study team will be held after day 43 (week 6) visit of the third subject enrolled. after the data from enrolled subjects is reviewed in the meeting, dose escalation to the next dose will be determined, based on the number of subjects experiencing dose-limiting toxicity (dlt).

Eligibility criteria:
inclusion criteria: * adult males and females * hepatocellular carcinoma diagnosis (bclc stage b or c) * htert positive expression confirmed during the screening period * ecog score of 0 or 1 * child-pugh score of a * life expectancy \>= 3 months exclusion criteria: * moderate or severe ascites * history of hepatic encephalopathy * carcinomas other than hcc * current or history of hiv positive * not suitable for inclusion judged by the investigator
effects of snuff and/or red wine om metabolic rate

Conditions: Metabolic Rate; Hunger; Insulin Sensitivity

Summary: about 14 healthy participants, consume a standardized breakfast combined with either using regular or nicotine-free moist snuff. the metabolic rate is measured every hour for four hours on each occasion starting in the morning. participants are also randomized to get red wine or non-alcoholic red wine to the meal.

about 14 healthy participants, consume a standardized breakfast combined with either using regular or nicotine-free moist snuff. the metabolic rate is measured measured before the meal and then every hour for a total of four hours on each occasion that starts in the morning. participants are also randomized to get red wine or non-alcoholic red wine to the meal. since there are four possible combinations of the wine and the snuff, all participants do the test on four occasions. except for metabolic rate we will also analyze hormone responses regarding appetite or hunger.

Eligibility criteria:
inclusion criteria: no significant disease - exclusion criteria: known illnesses, thyroid disease, need to take prednisolone, psychiatric disease,inability to understand swedish -
use of the thrombectomy device revive™ se in the acute treatment of stroke

Conditions: Stroke

Summary: the last marketed thrombectomy devices, named stentretriever, permit a better and faster recanalization in patient with a stroke. the revivetm se is a device designed to restore the brain perfusion in patient with an intracranial artery occlusion. the revivetm se device is not widely use in europe and in france. the objective of this study is to assess the interest of using this device in the standard care of ischemic stroke in the radiology unit of the hospital pierre wertheimer, lyon. the medical care will not be modified but data will be collected in order to determine whether or not this device is useful for the practice of the radiology unit.


Eligibility criteria:
inclusion criteria: * patient with an ischemic stroke detected by computed tomography (ct) or magnetic resonance image (mri) * large proximal arterial occlusion : m1 segment of the middle cerebral artery (mca), internal carotid artery (ica) or basilar artery (ba) * last known well (without neurological symptoms) ≤ 8 hours of treatment initiation * score nihss ≥4 * eligibility on an endovascular procedure using revivetm se device * no opposition of the patient to participate at the study exclusion criteria: * diagnostic cerebral imaging impossible * distal occlusion * tortuous vessel or other specificity preventing the access of device * vessel diameter \< 1.5 mm * known hypersensibility or allergy to nitinol * subjects not covered by or having the right to social security * deprivation of civil rights (guardianship, safeguard justice)

Keywords: stroke thrombectomy revivetm se mri computed tomography
status and develepment mental quality of life copd/ipf inpatients before and after pulmonary rehabilitation

Conditions: Idiopathic Pulmonary Fibrosis and COPD

Summary: as the result of our last study "long term effects of an inpatient pulmonary program in patients with pulmonary fibrosis" already demonstrated the positive effects of a pulmonary rehabiliation on the mental status. in this current study the aim will be to analyse the personality type regarding anxiety and depression


Eligibility criteria:
inclusion criteria: * copd gold iii-iv * ipf according pulmonary guidelines exclusion criteria: \< 30% fvc comorbidities with a negativ influence on the prognosis neurological and orthopaedic deficits, which make the participation of the pulmonary rehabilitation impossible non-compliance no written informed consent of the patient

Keywords: pulmonary fibrosis copd pulmonary rehabilitation mental status (anxiety and depression) quality of life physical activity
the african critical illness outcomes study

Conditions: Critical Illness; Mortality

Summary: in africa, the prevalence of critical illness is likely to be higher due to a greater burden of disease, and the associated mortality higher due to limited resources. this is a prospective, observational study to rapidly establish the prevalence of critical illness in in-hospital adult patients in africa, and the resources available to provide essential critical care (care that should be available to every patient in the world) and factors associated with mortality. rapid dissemination of these findings may help mitigate mortality from critical illness in africa. these points provide the rationale for the african critical illness outcomes study.

study objectives the objectives of this study are to determine: 1. the proportion of hospital patients who are critically ill, 2. the mortality associated with critical illness, 3. the proportion of critically ill patients who receive essential emergency and critical care, 4. the relationship between essential emergency and critical care provision, and mortality, and 5. the availability of resources necessary to provide essential emergency and critical care. study design an african multi-centre prospective observational cohort study of adult (≥18 years) in-hospital patients. patient follow up will be for a maximum of 7 days in-hospital. the primary outcome is in-hospital mortality in adult hospital patients with and without critical illness in africa. the intention is to provide a representative sample of the mortality, the risk factors associated with mortality in adult patients with critical illness, and the resources available and interventions provided to treat critical illness in africa. this study will run between september and november 2023. preparatory work this study will be run by the african perioperative research group (aporg), with a network of over 600 hospitals in more than 40 african countries which has successfully conducted the african surgical outcomes study (asos), the asos-2 trial, the african covid-19 critical care outcomes study (acccos) and the african pediatric surgical outcomes study (asos-peds). importance of this study to decrease the mortality associated with critical illness in africa, it is important to rapidly establish the potential risk factors for mortality, and resources available to manage these patients. the aporg network has the capacity to provide these data timeously.

Eligibility criteria:
inclusion criteria: * all adult patients aged 18 years or over who have been admitted for inpatient care in any department or ward in participating hospitals. exclusion criteria: * none
post splenectomy infections after surgery for peritoneal malignancies (opsi)

Conditions: Infection;Post Surg Procedure; Peritoneal Cancer

Summary: the spleen is involved in maintaining immunity and plays an important role in the elimination of encapsulated bacteria and parasites. patients who undergo splenectomy in conjunction with complete crs for peritoneal malignancy are at risk of overwhelming post-splenectomy infections post-operatively. these patients are therefore administered vaccinations to lower the risk of infections but as they do not completely eliminate the risk, patients are also prescribed prophylactic antibiotics without clear evidence that they are useful in preventing opsi. the use of prophylactic antibiotics is not without risk with potential short and long-term risks including resistance, interaction with other medication, clostridium difficile infections, fungal infections, other changes to the microbiome and cost. this study will investigate the incidence of opsi post splenectomy and assess compliance with prophylactic antibiotics. this is an observational study where consented patients will be telephoned at fixed time points which are 1,6,12 weekly and 6 monthly for a period of five years post-operatively. as part of routine care patients will be telephoned by the clinical nurse specialist at weeks 1,6 and 12. in addition to this the research nurse will telephone the patient 6 monthly for a period of 5 years and complete a questionnaire. the research nurse will complete the questionnaire during each telephone call and this should not take more than 20 minutes. at the start of the telephone call, consent will be confirmed each time and the research nurse will check that the patient is still happy to participate before going ahead.


Eligibility criteria:
inclusion criteria: - patients aged \>18 and \<80 years patients capable of providing informed consent patients who have a splenectomy in conjunction with complete cytoreductive surgery (crs) for any pathology exclusion criteria: - patients who are \ 80 patients who do not provide informed consent patients on immunosuppression therapy
colpac (radico cohort) (radico-colpac)

Conditions: Low Phospholipid Associated Cholelithiasis

Summary: the goal of this observational study is to describe the various clinical, biological and radiological manifestations of lpac syndrome, defined according to standard diagnostic criteria, or according to criteria extended to all symptomatic recurrent biliary lithiasis, and delineate the various possible evolutions. participants will be followed for 5 years and the inclusion sites will collect the necessary data at least once a year as part of routine patient care. a quality of life self-questionnaire will be completed by participants during these visits.


Eligibility criteria:
inclusion criteria: * children or adults meeting the standard\* or extended\*\* diagnostic criteria for lpac syndrome: 1. first symptoms before the age of 40 years 2. radiological images compatible with the existence of intrahepatic lithiasis 3. recurrence of symptoms after cholecystectomy (\*) standard criteria: symptomatic biliary lithiasis with at least 2 out of 3 criteria (\*\*) extended criteria: symptomatic biliary lithiasis with 1 out of 3 criteria exclusion criteria: * patients who have undergone liver transplantation
validity and reliability of turkish version of bayer activities of daily living scale

Conditions: Alzheimer Disease; Activities of Daily Living

Summary: the aim of our study is to verify the validity and reliability of the turkish version of b-gya.

dementia refers to a condition in which individuals with brain damage have multiple cognitive deficits with impairment in activities of daily living (adl). therefore, the assessment of adl is one of the main criteria for evaluating dementia. adl disorders are often observed by caregivers before they are identified by psychometric testing, thus suggesting that adl assessment can contribute to the early detection of dementia. evaluation of adl has become increasingly important with the introduction of new drugs for alzheimer's disease (ad), as well as being a helpful tool in diagnosis. current guidelines have recognized the need for therapeutic intervention in ad to measure and document treatment effects on adl. it has been emphasized that internationally validated and approved test tools to evaluate dementia are important for multinational clinical drug trials that evaluate the efficacy of anti-dementia drugs. therefore, it is of great importance to find adl scales that can be used internationally. various adl scales have been developed, such as lawton's instrumental adl (iadl), functional activities questionnaire (faq), adcs-adl, and bayer adl (b-adl). of these, w-adl was developed based on an international pilot study to evaluate adl deficits in patients from different cultural backgrounds. specifically, through a collaborative study conducted in four different countries during the development of the rda, the researchers prepared 141 items and selected 25 of them that could be used internationally. the target group of the scale included elderly patients suffering from mild to moderate dementia or cognitive impairment. european countries: in the united kingdom, germany, and spain, the validation study of the b-adl was carried out in three stages. the aim of our research is to verify the validity and reliability of the turkish version of b-adl.

Eligibility criteria:
inclusion criteria: * individuals aged 60 and over * being literate * having given consent to participate in the study * individuals diagnosed with alzheimer's according to the international diagnostic criteria of the american national neurological and communication disorders stroke and alzheimer's association (nincds-adrda) and in mild and moderate stages (\<2) according to the clinical dementia rating: cdr will be included in the study. exclusion criteria: * those who did not give consent to participate in the study * cdr\>2 * except for behavioral or functional symptoms associated with dementia, individuals with medical, psychiatric, neurological conditions, or physical disabilities that may significantly affect the performance of adl will be excluded from the study.

Keywords: alzheimer's disease activities of daily living
physical activity intervention for trauma afflicted refugees

Conditions: PTSD; Depression, Anxiety; Physical Activity

Summary: this study evaluates the effects of a 10-session physical activity intervention for trauma afflicted refugees. half of participants will receive this 10-session physical activity intervention and half of the participants will be allocated to the control group.

physical activity, particularly when performed in social settings, has been found to constitute an effective stress reliever and has been associated with improved physical and mental well-being, functional capacity and overall life satisfaction, as well as decreased risk of lifestyle diseases in various populations. physical activity can also revert symptoms of psychiatric disorders such as depression, anxiety, social isolation and dissociation, which is common among trauma afflicted refugees. many refugees also suffer from ptsd, and so the investigator's aim is to evaluate what effect a 10-session physical activity intervention will have on the mental and physical health of trauma afflicted refugees in a northern european country. the sessions will include physical exercise as well as psychoeducational components, and will be held by a physiotherapist over a period of ten weeks. the physical activity intervention group will be compared to a control-group, who receives two brief lectures on psycho-education in connection to baseline-assessment and follow-up.

Eligibility criteria:
inclusion criteria: * arabic/persian speaking persons. * persons with refugee background referred to the swedish red cross treatment center for trauma related to war and/or torture. * person able to undertake physical activity in a group setting. exclusion criteria: * current serious suicidal ideation, psychosis, serious cognitive impairments, current substance abuse, acute physical injuries or other health conditions that constrain physical activity.

Keywords: mental health physical activity