Kornimate/medical-research-clean huggingface dataset:
association between cd163 gene polymorphisms and sepsis among chinese han population

Conditions: Sepsis

Summary: cd163 is a member of the scavenger receptor cysteine-rich family (srcr) is exclusively expressed on cells of the monocyte lineage.cd163 acts to amplify inflammation and serves as a critical mediator of inflammatory response in the context of sepsis. this study was designed to investigate whether cd163 genomic variations were associated with the prognosis of sepsis. we sequenced 30 sepsis patients with cd163 gene of seventeen exons by pcr sequencing. when analyzing the results of sequencing, we found five gene polymorphisms located in exon-2,exon-5 and exon-11, respectively. compare with the ncbi dbsnp and hapmap database, one polymorphisms located in exon-2 is non-synonymous variation rs3210140, two polymorphisms located in exon-5 are synonymous variations rs4883264 and rs4883263, the last two located in exon-11 are synonymous variations rs61729512 and rs150018775 . five common polymorphisms (rs2234237,rs2234246) within the cd163 gene were detected in 200 patients with severe sepsis and in 200 healthy control subjects. this study was explored that whether or not polymorphisms detected within the cd163 gene may play a major role in the predisposition to prognosis of sepsis in a chinese han cohort.


Eligibility criteria:
inclusion criteria: * sepsis met the criteria recommended by 1991 accp/sccm joint meeting and by the diagnostic criteria developed at the 2001 international sepsis definition conference. exclusion criteria: * (1) younger than 18 years of age; (2) acquired immunodeficiency syndrome; (3) reduced polymorphonuclear granulocyte counts (\< 500 μl-1); (4) died within 24h after admission into the icu, or refused to participate in the study, or declined treatment during the period of observation.

Keywords: cd163; snps; prognosis; control（normal person）
do antibiotics prevent anal fistulae formation?

Conditions: Anal Fistula

Summary: purpose: this randomized study assesses the effects of antibiotics on the formation of fistulae after drainage of anorectal abscesses. methods: patients who underwent abscess drainage in 3 major colorectal units between september 2005 and january 2008 were included. previous anorectal surgery history, immunecompromised states, pregnancy, inflammatory bowel disease, antibiotic usage prior to surgery and the presence of an anal fistulae at the time of surgery were the exclusion criteria. patients were randomized and given either placebo or amoxicillin-clavulanic acid combination treatment for 10 days. patients were followed one year for perianal fistulae formation.


Eligibility criteria:
inclusion criteria: * presence of anorectal abscess exclusion criteria: * allergy to penicillin derivatives * treatment with any antimicrobial agent in the week before enrolment * recognized other infection at the time of surgery * previous anorectal surgery * presence of inflammatory bowel disease * suspicion of fournier's gangrene * secondary and recurrent anorectal abscesses * presence of an internal opening * any additional surgical procedure performed in the same session or during follow-up * antibiotic prophylaxis indicated for another reason * immunosuppressive and/or anticoagulant drug treatment being taken at the time of surgery * diabetes mellitus * known chronic disabling disease * pregnancy * lactation.

Keywords: perianal abscess fistulae in ano antibiotic anorectal
possible differences in hcc course depending on daa treatment

Conditions: Carcinoma, Hepatocellular; Hepatitis C Virus Infection, Response to Therapy of; Drug Effect; Drug Side Effect; Hepatitis C, Chronic; Liver Cirrhosis

Summary: background it is estimated that around 71 milion people live with chronic hepatitis c virus (hcv) infection. this may lead to the development of liver cirrhosis and hepatocellular carcinoma (hcc). liver cirrhosis is considered as one of the most common risk factors of hepatocellular carcinoma (hcc). hcc is seventh most common cancer worldwide. the treatment of hcv with direct-acting antivirals (daas) has led to the increase of sustained virological response (svr) rates to more than 90%. it is suggested that the virus eradication reduces, but not eliminates the risk of hcc. this concerns especially patients with liver cirrhosis or previous hcc history. there are reports of early occurrence of hcc after the daa treatment. therefore, patients undergoing successful hcv treatment should be monitored for the possibility of hepatoccelular carcinoma occurrence. aim of the study in this study the investigators aimed to assess the occurrence of hcc after direct acting antiviral hcv treatment and evaluate whether the course of hcc and liver function differ among the population of patients treated with daas and those who were not receiving the therapy with daa. material and methods this is the observative, cohort, retrospective study which will be performed in several clinical centres in poland. the inclusion criteria are: hepatocellular carcinoma diagnosis, age \>18 years old. the investigators will collect both epidemiological (age, gender, comorbidities, alcohol abuse) and clinical data (serum bilirubin, alanine, aspartate aminotransferase, platelets, gammaglutamyltransferase, alkaline phosphatase and alpha-fetoprotein level, child-pugh and meld score, imaging tests, liver biopsy and elastography, if performed). in all patients, the hcv infection and co-infections will be assessed. in those who underwent the daa treatment, the composition of the therapy and response to the treatment will be evaluated. statistical analysis will be performed in subgroups of patients undergoing daa treatment and without the therapy. the distribution of continuous variables will be analysed by the shapiro-wilk test. quantitative data will be analysed using the mann-whitney u test or kruskal-wallis anova when appropriate. qualitative data will be compared using the χ² test or the fisher exact test. correlations between quantitative variables will be assessed using the spearman correlation coefficient. p value will be set at \<0.05. funding: no remuneration is provided for participation in the study


Eligibility criteria:
inclusion criteria: * hepatocellular carcinoma diagnosis * age \>18 years old exclusion criteria: * age \<18 years old

Keywords: hepatocellular carcinoma hepatitis c direct-acting antiviral agents
treatment of psoriasis using acitretin in hiv-positive patients

Conditions: HIV Infections; Psoriasis

Summary: to determine the efficacy of acitretin in the treatment of psoriasis in hiv/aids patients. etretinate, a retinoid, has proven successful in the treatment of hiv-infected patients with psoriasis, but it has an elimination half-life of 100 days. acitretin, a metabolite of etretinate, has a much shorter half-life of 2 to 3 days. acitretin has proven effective in treating psoriasis in patients without hiv infection by reducing skin involvement and clearing of the condition, but it has not been thoroughly evaluated in hiv-infected patients.

etretinate, a retinoid, has proven successful in the treatment of hiv-infected patients with psoriasis, but it has an elimination half-life of 100 days. acitretin, a metabolite of etretinate, has a much shorter half-life of 2 to 3 days. acitretin has proven effective in treating psoriasis in patients without hiv infection by reducing skin involvement and clearing of the condition, but it has not been thoroughly evaluated in hiv-infected patients. patients receive acitretin daily, with dose increases every 4 weeks based on quantitative assessment of the skin using the psoriasis area and severity index (pasi). treatment continues for a total of 20 weeks. patients are followed every 2 weeks.

Eligibility criteria:
inclusion criteria concurrent medication: allowed: * any nondermatologic medication. patients must have: * hiv infection. * psoriasis involving at least 10 percent of body surface.

Keywords: psoriasis acquired immunodeficiency syndrome aids-related complex acitretin
the effect of fluorouracil implants regional chemotherapy during the surgical treatment for early stage hepatocellular carcinoma

Conditions: Early Stage Hepatocellular Carcinoma

Summary: this study will assess the clinical efficacy and safety of fluorouracil implants regional chemotherapy during the surgical treatment for early-stage hepatocellular carcinoma.


Eligibility criteria:
inclusion criteria: * histological diagnosis of stage i hepatocellular carcinoma * child-pugh class a, b * radical resection is feasible * patients with adequate renal, hepatic, and hematologic function * written informed consent exclusion criteria: * allergic to chemotherapy drugs * no measurable lesion * receive chemotherapy, radiotherapy or biotherapy within 30 days prior to enrollment * evidence of serious infection * renal or hepatic dysfunction, significant cardiovascular disease * pregnant or lactating women

Keywords: fluorouracil implants hepatocellular carcinoma radical resection
investigation of 9 consecutive remicade infusions in ankylosing spondylitis in austria (study p04044)(completed)

Conditions: Spondylitis, Ankylosing

Summary: this is a prospective, open-label, 1-arm, multicenter observational study to determine the dose and time span of remicade between infusions for ankylosing spondylitis (as).

this study population was chosen from a non-probability sample.

Eligibility criteria:
inclusion criteria: * subjects with ankylosing spondylitis with severe axial symptoms and elevated serological markers of inflammatory activity. exclusion criteria: * subjects with tuberculosis or other severe infections such as sepsis, abscesses, and opportunistic infections. * subjects with moderate or severe heart failure (new york heart association (nyha) class iii/iv). * subjects with a history of hypersensitivity to remicade or to other murine proteins, or to any of the excipients.
the treatment of human bone marrow mesenchymal stem cells in ocular corneal burn

Conditions: Chemical Burns

Summary: ocular chemical burn is one of the cause of vision loss in our country, and there are no satisfactory treatment. human bone marrow mesenchymal stem cells (msc) have the biological characteristics of self-renewal, immune regulation, multidirectional differentiation and tissue repair. our preliminary research showed that in corneal alkali injury rats, the msc can accelerated the cornea repair, inhibited angiogenesis. the aim of this study is to access the efficacy and safety of mesenchymal stem cell in the treatment of corneal burn in human.

corneal burn is a ocular damage disease included chemically burned and thermally burned. surgery of corneal transplantation，amniotic membrane transplantation are some of effective,however,these therapy are expensive and the transplantation resources are limited. to arrest the inflammatory phase, several types of immunosuppressive treatments have been investigated. corticosteroids also is important, however, long time usage of corticosteroids often cause severe side-effects. human bone marrow mesenchymal stem cells (msc) have the biological characteristics of self -renewal, immune regulation, multidirectional differentiation and tissue repair. our preliminary research showed that in corneal alkali injury rats, the msc can accelerated the cornea repair, inhibited angiogenesis. many animal research also revealed that msc have effect on the ocular alkali burned. and subconjunctivity injection is efficient, the clinical study of msc on treating other disease have been developed rapidly recently, in further ,the outcome are encouraging, and no side-effect related msc was reported, msc can come from bone marrow, umbilical cord blood，adipose tissue and so on, but bone marrow msc is mostly common used. the investigators propose to assess the efficacy and safety of human bone marrow mesenchymal stem cell in the treatment of corneal burn in human.

Eligibility criteria:
inclusion criteria: 1. must be ocular burns including chemically burned or the thermally burned 2. the severity degree should above the ⅳ degree,including the ⅳ degree(according the classification of dua standard,2001) 3. the subjects are willing to accept this research,and promise to coordinate with the researchers during the follow up period 4. the subjects should abide by the laws and rules of the study. 5. the incident time should be within 2 weeks - exclusion criteria: 1. the visual acuity is blind in any of the eye 2. have corneal perforation or have the corneal perforation tendency 3. have been accepted surgury on eyeball after trauma 4. iop≥25mmhg even after antiglaucoma 5. have the history of other corneal diseaze or surgury 6. have the history of radiotherapy or surgury in the eyeball 7. associated with corneal ulcer or endoophthalmitis 8. uncontrolled hypertension(≥150/95mmhg) 9. abnormal liver and renal function 10. the pregancy women -
a study to assess the effect of smart insulin pens on glycemic control and diabetes-related burdens

Conditions: Type 1 Diabetes

Summary: the purpose of this study is to see if the use of the inpen® for teens and young adults up to age 21 years with type 1 diabetes helps to decrease burden and improve glycemic control.

investigators will perform a randomized, cross-over prospective interventional study. half of the participants will be randomized to the inpen® and the other half will continue with their conventional insulin injection protocol. after 90 days, participants will switch to the second arm. randomization will occur via block randomization. teaching to use the inpen® will be done by sarah jackson, do with supervision by ana creo, md, which can be done by a telemedicine visit if it does not align with clinic visit. you will be followed for three months with hemoglobin a1c at the beginning and the end of the study. data from the (continuous glucose monitor (cgm) and inpen® will be analyzed including time in glucose goal range (70-180 mg/dl), glucose standard deviation, percentage of time that is spent high (\>180-250 mg/dl), very high(\> 250 mg/dl), low(54-70 mg/dl) and very low(\<54 mg/dl), along with total daily insulin dose. data on missed insulin doses will be assessed via data from the inpen®. you will be randomized to traditional injections we will ask them to record missed insulin doses weekly. you should still adjust insulin doses at home, like they do at baseline. if insulin adjustments are made while in one arm of the study they should still continue that dosing when they cross over. investigators will also assess quality of life and fatigue related to technology with surveys prior to start of the study and at the end. specifically, investigators will assess diabetes distress, transition readiness, and parental experience of childhood illness scales. investigators will also utilize the insulin delivery satisfaction survey to assess how you view your current regimen and then how you view the effects of the inpen in managing your type 1 diabetes.

Eligibility criteria:
inclusion criteria: * individuals between the ages of 13 and 21 years. * patients with type 1 diabetes for at least 6 months * defined as either a c peptide \<1 , one or more positive diabetes autoantibodies, or a clinical diagnosis with age of onset prior to puberty * patients who currently receive insulin injections with a cgm. * english speaking. * have access to a smart phone. on an insulin to carbohydrate ratio exclusion criteria: * individuals less than 13 * non-english speaking. * no access to a smart phone. * intellectual disability that would impact their ability to utilize the technology * known pregnant women taking chronic steroids (equivalent equal to or greater then 5mg of prednisone daily)

Keywords: adolescents young adults continuous glucose monitoring (cgm)
a phase 3 study of bardoxolone methyl in patients with diabetic kidney disease; ayame study

Conditions: Diabetic Kidney Disease

Summary: the purpose of this study is to demonstrate the efficacy of multiple oral doses of rta 402 (5, 10, or 15 mg) administered once daily in patients with diabetic kidney disease (dkd) using the time to onset of a ≥ 30% decrease in estimated glomerular filtration rate calculated from serum creatinine (egfr) from baseline or end-stage renal disease (esrd) as an indicator in a randomized, double-blind, placebo-controlled study; the safety of rta 402 will also be evaluated.


Eligibility criteria:
inclusion criteria: * patients with dkd * mean egfr ≥ 15 and \< 60 ml/min/1.73 m² * albumin/creatinine ratio (acr) ≤ 3500 mg/g cr * treatment with an angiotensin converting enzyme (ace) inhibitor and/or an angiotensin ii receptor blocker (arb) with no change in dosage or medication etc. exclusion criteria: * diabetes mellitus that is neither type 1 nor type 2 * decreased renal function mainly attributed to a non-diabetic cause * history of renal transplantation or upcoming preemptive renal transplantation * confirmed mean systolic blood pressure \> 160 mmhg or a confirmed mean diastolic blood pressure \> 90 mmhg during the 8-week period before screening * hemoglobin a1c level \> 10.0% during screening * serum albumin level ≤ 3.0 g/dl during screening * cardiovascular disease specified in the study protocol * history of cardiac failure * bnp level \> 200 pg/ml during screening etc.

Keywords: bardoxolone methyl diabetic kidney disease diabetes mellitus kidney diseases
acute effects of incremental inspiratory loads on respiratory mechanics and nrd in patient with stable copd.

Conditions: Chronic Obstructive Pulmonary Disease

Summary: inspiratory muscle training has been an important part of pulmonary rehabilitation program directed at patients with copd. it can increase respiratory muscle strength, relieve dyspnea ,improve the quality of life in copd patients. however, there is no uniform standard for the intensity of inspiratory muscle training. by comparing a series of indexes, such as maximal inspiratory pressure, maximal expiratory pressure, degree of dyspnea and exercise capacity before and after the training under different intensity, a large number of literatures have explored the appropriate intensity of inspiratory muscle training. but to date, there are few studies about the effects of different intensity of inspiratory muscle training on respiratory physiological mechanism. it has been shown that inspiratory muscle training may be more beneficial to improve the pulmonary rehabilitation effect of copd patients with inspiratory muscle weakness. so it is not clear whether there is a difference in respiratory physiology between patients with normal inspiratory muscle strength and those with lower inspiratory muscle strength. respiratory central drive, as an important physiological index, which can be reflected by minute ventilation volume, mouth pressure, mean inspiratory flow and diaphragm electromyography,is closely related to the symptoms and the severity of the disease.therefore,the purpose of this study was to investigate the changes of respiratory mechanics and central drive in copd patients at different inspiratory loads, and at the same loads between patients with and without respiratory muscle weakness.that can provide more evidential evidence for setting up the intensity of inspiratory muscle training.

the patients with copd will be admitted in one intervention groups(performing on threshold loading device).before using threshold loading device, we will measure the relevant parameters of lung volume, respiratory flow,diaphragm electromyogram, central drive mechanical and other baseline index.then incremental inspiratory load will be applied to investigate the effects of inspiratory load on the above mentioned respiratory mechanics parameters.

Eligibility criteria:
inclusion criteria: - patients with pulmonary function test of forced expiratory volume at one second (fev1)/forced vital capacity(fvc) \< 70% after inhalation of bronchial dilation agent. patients in a clinically stable state. exclusion criteria: - patients were excluded if they had other respiratory diseases ,or evidence of pneumothorax or mediastinal emphysema and pacemaker installed. patients with acute cardiovascular event and severe cor pulmonale. patients with poor compliance. an other causes of diaphragmatic dysfunction

Keywords: chronic obstructive pulmonary disease inspiratory muscle training central drive
comparative effectiveness of the two splints in trigger finger

Conditions: Trigger Finger

Summary: rme orthosis is recommended for the treatment of trigger finger. however, its efficacy has not been studied in trigger finger patients. given the increasing popularity of this orthosis among clinicians, it is important to evaluate their effectiveness to provide evidence for its use in trigger finger. the purpose of this study was to compare the efficacy of a 6-week orthotic intervention in a randomly selected group of patients with trigger finger using mcp-blocking and rme orthoses.

generally, three types of orthoses are used in the treatment of trigger finger. some authors used mcp blocking orthosis, while others used dip or pip blocking orthosis. comparative studies are quite limited, as only one study comparing two orthotic designs found that the mcp blocking orthosis was more effective than the dip blocking orthosis.the mcp blocking orthosis, which restricts the mcp joint to 10-15° of flexion, is commonly used in the conservative treatment of trigger finger.an rme orthosis could be an alternative orthotic treatment option for trigger finger because it holds the mcp in an extended position. the rme orthosis is thought to prevent flexion of the affected finger, thereby limiting tendon glide. this reduces the pressure on the a1 pulley, allowing the tendon to glide more smoothly, reducing the likelihood of triggering. despite limiting motion,the orthosis still allows the patient to perform daily activities with the orthosis. therefore, positioning the mcp joint in extension could provide additional benefits in trigger finger. the relative motion orthosis is a new orthotic design that positions the affected finger in 10-15 degrees of extension relative to the adjacent fingers.it also has several advantages, including small size, low-profile design, easy and inexpensive fabrication, and better patient compliance. the primary objective of this study was to compare the efficacy of a 6-week orthotic intervention for pain relief in a randomly selected group of patients with tf using the mcp blocking orthosis and the rme orthosis. the secondary objective was to determine the comparative effectiveness of the orthoses on function and satisfaction with the orthosis.

Eligibility criteria:
inclusion criteria: * patients diagnosed with stage 1-3 trigger finger (froimson classification) * a1 pulley triggering exclusion criteria: * trigger thumb * multiple trigger fingers on one hand * neurological disorders * rheumatologic diseases * pregnancy * patients who had received a steroid injection in the affected finger within the previous six months * patients who had previously undergone trigger release surgery

Keywords: trigger finger relative motion splint pain function satisfaction static splint