Kornimate/medical-research-clean huggingface dataset:
influence of inspiratory flow pattern on exchange of carbon dioxide in humans without primary lung disease

Conditions: Pulmonary Gas Exchange; Carbon Dioxide

Summary: the purpose of this study is to investigate how inspiratory flow pattern influences co2 elimination in people without primary lung disease. the hypothesis is that a long mean distribution time, caused by a long postinspiratory pause and high end-inspiratory flow, will promote co2 exchange in the alveoli.


Eligibility criteria:
inclusion criteria: * no known primary lung disease exclusion criteria: * primary lung disease
morbimortality in older patients undergoing urgent abdominal surgery

Conditions: Surgery--Complications

Summary: morbimortality in older patients undergoing abdominal surgery.

the aim of this study is to validate the modified cristal tool for 30 mortality in elderly patients undergoing urgent abdominal surgery. to provide a new tool that could be used in conjunction with clinical judgment to aid in decision-making. the second objective of our study was to assess the quality of life, frailty, functional status and nutritional status in elderly patients that survive six months after an urgent abdominal surgery.

Eligibility criteria:
inclusion criteria: * \>65 years old, accepted in emergency department exclusion criteria: * not sign the consent

Keywords: urgent abdominal surgery. quality of life, functional status, frailty, nutritional status
tissue samples and bodily fluid specimens banking

Conditions: Endocrine Disorders of Female Reproductive System

Summary: the purpose of this study is to collect a portion of blood/tissue specimens that will be generated during the participants office visit or surgery. the investigators are asking whether a small portion of the specimen/s could be set aside and banked for future research purposes. data originating from participants will be gathered and analyzed in research studies that will help understanding various medical conditions such as polycystic ovary syndrome (pcos), congenital uterine malformations, endocrine malfunctions, endometriosis, and infertility.

purpose: women present to the reproductive endocrinology clinic with different concerns. these may involve conditions such as pelvic pain, endometriosis, mullerian anomalies, polycystic ovary syndrome, abnormal uterine bleeding, menopausal symptoms, or infertility. understanding the meaning of different biologic markers in their blood serum or tissues could help advancing the medical knowledge in the different conditions. rationale: to understand the meaning of different biologic markers in the patients' blood serum or tissue samples. population: patients identified among all women presenting to the reproductive endocrinology clinic. patients may undergo endometrial biopsy or surgery to evaluate their condition. in these instances, the investigators will ask the patients whether a small portion of their specimen/s could be collected and banked for future research purposes. design: prospective blood/tissue collection. procedures: a small portion of the patient's blood or tissue specimen collected at the time of a medically indicated blood draw or surgical procedure will be collected and banked for future research purposes. sample collection will be performed on existing specimens, once the specimens have been obtained for medical indications. no additional procedures will be performed on the patients for research purposes only. outcome measures: creation of a blood serum/tissue specimens bank for future clinical research studies.

Eligibility criteria:
inclusion criteria: * females of childbearing potential experiencing reproductive endocrinology related problems. exclusion criteria: * male or female not of childbearing potential
long term follow-up on menkes disease patients

Conditions: Menkes Disease

Summary: this study will collect long term follow-up data regarding overall survival and neurological parameters from patients previously identified and/or enrolled in protocols 09-ch-0059 and 90-ch0149 and historical control data on menkes disease patients.

primary objective: 1. to provide additional clinical and safety data on long term following administration of copper histidinate treatment in patients treated with copper histidinate under protocols 09-ch-0059 and 90-ch0149 and untreated patients previously identified and/or enrolled in protocol 09-ch-0059. 2. to provide additional historical control data on menkes disease patients.

Eligibility criteria:
inclusion criteria: * the subject must have been previously identified and/or enrolled under protocols 09-ch-0059 or 90-ch-0149; or an untreated menkes disease patients for whom data collection is incomplete under protocols 09-ch-0059 (amendment m); or other untreated menkes disease patients. * must sign and date an informed consent form by parent or legal guardian for this study prior to any assessment being done in this study. if the patient is \> 18 years of age, the patient must sign the informed consent. * male or female, aged 0 to \< 65 years of age. exclusion criteria: - unwillingness/unable to participate in the study.
bioavailability and effectiveness of transdermally administered morphine

Conditions: Cancer; Pain

Summary: patients will participate in two arms of the trial, one in which morphine will be administered transdermally, and, after a 3 day wash out period, one in which morphine will be administered subcutaneously.

patients will participate in two arms of the trial, one in which morphine will be administered transdermally, and, after a 3 day wash out period, one in which morphine will be administered subcutaneously. blood draws will be done after both dosing methods in order to compare blood levels of morphine by the different routes.

Eligibility criteria:
inclusion criteria: * chronic cancer pain * minimum baseline pain of 3/10 * no change in medications over 3 days prior to study period * ability to give informed consent * willingness to undergo repeated blood sampling exclusion criteria: * use of morphine or codeine in 3 days prior to study * known sensitivity to morphine * prior anaphylactic reaction to any opioid * clinically significant anemia

Keywords: transdermal morphine cancer pain bioavailability pharmacokinetics cancer related pain stable baseline pain currently taking opioids
"wai ji match fun" card games for people with intellectual disabilities

Conditions: Adults With Intellectual Disability

Summary: a new set of card game, wai ji match fun (wjmf), has been developed by wai ji christian service (wjcs), a non-governmental organization in hong kong, specifically designed for individuals with intellectual disabilities (id). the game aims to enhance cognitive performance and psychosocial well-being while facilitating daily participation.

this study evaluates the feasibility and acceptability of wjmf for individuals with id, and its immediate and carry-over impacts on psychosocial well-being and cognitive function. sixty-four adult participants with mild to moderate id were recruited for the study. each participant attends a weekly 60-minute wjmf group program over an 8-week period. groups of four participants are facilitated by occupational therapists or rehabilitation assistants. outcome measures include the personal wellbeing index - intellectual disability (pwi-id) (chinese-cantonese version), the short version of the prudhoe cognitive function test (pcft), attendance rates, and staff feedback on feasibility and acceptability.

Eligibility criteria:
inclusion criteria: * service users attending residential or day training service units * aged 18 years or older * diagnosed with mild or moderate intellectual disability * able to engage in a 60-minute group session exclusion criteria: - exhibit disruptive behaviours that could hinder group progress

Keywords: card game intellectual disability cognition psychosocial wellbeing feasibility and acceptability
impact of hypovitaminosis d on bone disease in hiv infected patients

Conditions: Hypovitaminosis D

Summary: to determine the prevalence of hypovitaminosis d in hiv infected patients, and the consequences on secondary hyperparathyroidism, and bone mineral density (bmd). also, to establish the improvement in vitamin d status, parathyroid hormone (pth) and bmd, in case of receiving vitamin d supplementation, during a follow up period of at least 1 year.

this study deals with the impact of vitamin d on metabolism and bone health in hiv infected patients. to answer the questions about the importance of this hormone in this population, we designed a cohort study about the prevalence of vitamin d deficiency (measured as 25-hydroxy-vitamin d), classifying it in severe deficiency (\ 65 pg/ml), and related bmd by dual x-ray absorptiometry (dxa). these results will be adjusted by baseline factors, such as age, gender, body mass index (bmi), hepatitis c virus (hcv) coinfection, risk practice for hiv infection, cd4+ count, antiretroviral therapy, and hiv rna level. in patients receiving vitamin d supplementation according to clinical decision, it will be evaluated the changes in percentage of hypovitaminosis d and/or secondary hyperparathyroidism, and the effect on bmd. bone biomarkers will be collected to determine the impact of changes secondary to vitamin d improvement in the bone evolution.

Eligibility criteria:
inclusion criteria: * hiv older than 18 years exclusion criteria: * chronic kidney disease stage 4 and 5 (creatinine clearance \< 30 ml/min) * pregnancy * uso of corticosteroid therapy, or requiring anti-resorptive treatment * prolonged hospitalization or internment

Keywords: hiv, vitamin d, osteoporosis
combination therapy of microwave ablation and cellular immunotherapy for hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: the study is to observe safety, survival effect and peripheral t-lymphocyte subsets of combination therapy with percutaneous microwave ablation (mwa) and adoptive immunotherapy in hepatocellular carcinoma(hcc).

hcc (d ≤5 cm, fewer than three tumors) patients were treated with radical mwa and 4-6 courses of immunotherapy with cik every year. the immunotherapy were started at 2 weeks, 4 weeks, 6 weeks, 10 weeks, 14 weeks, 18 weeks and then every 12 weeks after mwa. peripheral blood mononuclear cells were differentiated into phenotypically confirmed dcs and effector cells. dc-cik and ctl were injected into the abdominal cavity. cik was infused intravenously. the safety, survival effect and peripheral t-lymphocyte subsets of combination therapy group will be recorded and compared with those of mwa group.

Eligibility criteria:
inclusion criteria: 1. single hcc of 5 cm or smaller; 2. three or fewer multiple hcc with a maximum dimension of 3 cm or less; 3. absence of portal vein thrombosis or extrahepatic metastases; 4. child-pugh classification a or b; 5. tumor accessible via a percutaneous approach. white blood cell count \>2 x 109/l, platelet count \>40 x 109/l,serum creatinine \<110 μmol/l, aspartate aminotransferase \<3 times the upper limit, serum bilirubin \<2.5 times the upper limit, prothrombin time \<19 seconds. exclusion criteria: 1. pregnant or breast-feeding; psychiatric problems, addiction, or any other disorder that prevented informed consent; 2. active uncontrolled infection; concurrent systemic corticosteroid treatment; 3. systemic autoimmune disease; 4. clinically significant ischemic heart disease or cardiac failure; 5. and chemotherapy or radiotherapy within the preceding 6 months

Keywords: hepatocellular carcinoma ablation immunotherapy cytokine induced kill cell
ginsenoside-rd for acute ischemic stroke

Conditions: Ischemic Stroke

Summary: the purpose of this study is to evaluate the efficacy and safety of ginsenoside-rd for acute ischemic stroke.

a major contributor to brain injury after stroke is disordered inward flow of ca2+ and its toxic accumulation in the nervous system following cerebral ischemia. ginsenoside-rd, a purified component from total saponins of panax notoginseng, has a molecular formula of c48h82o18•3h2o with a molecular weight of 1001.2. ginsenoside-rd has been shown to inhibit receptor-operated ca2+ influx through receptor-and-store-operated ca2+ channels (rocc) , attenuate oxidative stress in stroke, reduce the size of the cerebral infarction and preserve brain functioning in animal models of acute ischemic stroke.

Eligibility criteria:
inclusion criteria: * between 18 to 75 years * the first episode * from onset to admission within 72 hours * nihss scores:5\~22 exclusion criteria: * had other intracranial pathologies (e.g., tumor, infection) * had a neurologic or psychiatric disease * had a coexisting condition that limited their life expectancy * had significant drug or alcohol misuse * had high-grade carotid artery stenosis for which surgery was planned * were pregnant or nursing * participated in a clinical trial with an investigational drug or device within the past 3 months * were unlikely to be available for follow-up

Keywords: randomized trial ischemic stroke ginsenoside-rd
clinical outcomes of immediate implants with or without a volume-stable collagen matrix

Conditions: Edentulous Alveolar Ridge

Summary: the purpose of this study is to evaluate the soft tissue clinical results in patients that received, or not, a soft tissue augmentation around dental implant inserted immediately after the extraction.

after being informed about the study and potential risks, all patients giving written informed consent will undergo a screening period to determinate eligibility for study entry. patients who meet eligibility requirements will be randomized in this single blinded(investigator) study. group (test) will receive immediate implant after extraction and a soft tissue augmentation with a collagen matrix. group (control) will receive only immediate implant after extraction without soft tissue augmentation.

Eligibility criteria:
inclusion criteria: - presence of a single failing tooth in the esthetic region (second premolar to contralateral second premolar), the adjacent teeth should be present and without any dental pathologies. exclusion criteria: * patients who are heavy smokers (more than 10 cigarettes/day); * patients who suffer from any systemic diseases that could negatively influence wound healing; * patients who received head and neck radiation treatment; * patients who have a full contraindication to implant surgery; * patients who have uncontrolled periodontal disease; * patients who show a full mouth plaque and bleeding score higher than 25%; * patients who have deficient extraction sockets according to the classification of juodzbalys et al. 2008. * patients with known allergy, sensitivity or intolerance to collagen * patients who are pregnant or who are breastfeeding

Keywords: soft tissue augmentation immediate implant collagen matrix
follow-up of treatment outcome, quality of life, sexual life and partnership after surgery of endometriosis

Conditions: Endometriosis

Summary: follow-up of treatment outcome, quality of life, sexual life and partnership after surgery of endometriosis by means of a questionnaire 1 year after surgical intervention.


Eligibility criteria:
inclusion criteria: * surgery of endometriosis at frauenklinik of university hospital basel (from 01.01.2017 until 31.12.2017) * sufficient german language skills in order to be able to complete questionnaires exclusion criteria: * incapable of consenting

Keywords: quality of life treatment outcome sexuality partnership surgery of endometriosis
the relationship between fatty liver and breast cancer

Conditions: The Relationship Between Fatty Liver and Breast Cancer

Summary: clinicopathological result of a common is (nafld) alcoholic fatty liver disease-nno 30% of -nafld affects 20% .not caused by alcohol intake is chronic liver disease thatsuch as conditions spectrum of population and can be characterized by wide general et chalasani( steatosis by isolated intracellular fat deposition marked noninflammatory .al., 2012) homeostasis and egulation of hepatic cholesterol nafld occurs due to the dysr . nafld is liver in triglycerides and free cholesterol, free fatty acids, accumulation ofabdominal and with insulin resistance, diabetes mellitus, metabolic syndrome associatedimplicated in the be can nafld that suggested reports the arge number ofl .obesity kidney diseases as well as cancersf cardiovascular, pulmonary, and pathology o .2015) et al., (arguello their course of the patients with breast cancer commonly develop nafld during .45.2%-2.3% approximately cancer is disease. the incidence of nafld in breast by influenced metabolic profile and is patient's nafld seems to be associated with cardiovascular and resistance insulin causingand treatment, breast cancer complications (lee et al., 2017). modulators term estrogen inhibition with selective estrogen receptors-long liver with tamoxifen fatty incidence of the s been reported to cause nafld.ha (serms)of nafld development in impact het . use an that for aromatase inhibitoruse is higher th et al., (yang breast cancer patients after hormonal treatment has not yet been elucidated .)6201 main and is aworldwide most common cancer in womenbreast cancer is the decreasing with has been cancer breast from ityortalm .women in death cancer of causeit is well known time given the advances in screening strategies and adjuvant treatments. incidence of breast cancer is correlated with age and other risk factors such asthat the mutation, family history of )brca2( breast cancer gene2 or )brca1(gene1breast cancer al.,et berry( and hormonal factors chest the to breast cancer, therapeutic radiation5).200 breast cancer is divided according to the hormone receptors into either hormone receptor-positive tumors which are estrogen receptor-positive (er-positive) and progesterone receptor-positive (pr-positive). these tumors express hormone receptors. this means they have a lot of hormone receptors. hormone receptor-negative tumors are estrogen receptor-negative (er-negative) and progesterone receptor-negative (pr-negative). these tumors donot express hormone receptors. this means they have few or no hormone receptors. about 70% to 80% of newly diagnosed breast cancers are hormone receptor- .al., 2017) (wang et positive


Eligibility criteria:
inclusion criteria: * 65 years old)-age (18-1 performance (ps0;full active,noperformance status \ 50% of woking hours) exclusion criteria: * patients who had double malignancy.-1 patients who had severe comorbidities -2 heart failure.....etc,)(pulmonary failure,renal failure, those who declined cancer treatment before completing 85% of the planned dosage -3 hose who are lost during the follow up period.tor
timing of surgical intervention after percutaneous catheter drainage in step up approach for severe acute pancreatitis

Conditions: Acute Pancreatitis

Summary: 1. to determine the appropriate timing of surgical intervention after percutaneous catheter drainage (pcd) in infected pancreatic necrosis (ipn). 2. to see the change in morbidity and mortality after changing the interval of surgery after pcd

in present study we plan to determine the appropriate timing of surgical intervention after pcd in step up approach of infected pancreatic necrosis (ipn). the investigators also intend to evaluate the role of pcd in obviating the surgical intervention in the management of ipn and evaluate the risks \& benefits of extended treatment policy of pcd in step up approach of ipn in comparison to early surgery after pcd.

Eligibility criteria:
inclusion criteria: * all patients with diagnosis of ipn (uk guidelines) managed with percutaneous catheter drainage (pcd) for 10 to 15 days and not showing significant improvement on pcd will be included exclusion criteria: 1. patient showing significant improvement on pcd within 10 days of its insertion.(significant improvement on pcd is defined as resolution of fever, acceptance of enteral nutrition, decrease in total leukocyte count, reversal of organ system failure) 2. sterile pancreatic necrosis 3. an acute intra abdominal event ( perforation of hollow viscus, bleeding, or the abdominal compartment syndrome) during or within 10 days after pcd insertion 4. previous drainage or surgical necrosectomy for infected pancreatic necrosis (ercp with or without papillotomy is allowed.) 5. previous exploratory laparotomy for acute abdomen and diagnosis of pancreatitis during laparotomy
safety and efficacy study of new eye drop formulations with refresh tears® in patients with dry eye disease

Conditions: Dry Eye Syndromes

Summary: this study will investigate the safety, efficacy and acceptability of two new eye drop formulations compared with refresh tears® in patients with dry eye disease.


Eligibility criteria:
inclusion criteria: * current use of an artificial tear product at least twice daily for at least 3 months, on average * ability/agreement to continue wearing existing spectacle correction (glasses) during study exclusion criteria: * anticipated contact lens wear during study or contact lens use within 6 months * active ocular infection or allergy * use of any topical ophthalmic medications (eg, topical ophthalmic steroids, glaucoma drops) within 2 weeks * use of any topical cyclosporine products within 3 months
oncological and functional result of abdominoperineal extra levator resection for distal rectal cancer

Conditions: Rectal Cancer

Summary: the aim of the project is to evaluate the oncological and functional outcome of the more extensive perineal dissection - i.e the extra levator resection - in abdominoperineal resections in patients with rectal cancer. hypothesis: extra levator perineal resection reduces local recurrence three year postoperatively compared to traditional abdominoperineal resection and improves qol 2-4 years postoperatively.

low rectal cancer treated surgically by abdominoperineal resection (apr) has worse outcome than other rectal cancers operated with low anterior resection. in order to improve the outcome in the apr group a more extensive surgical procedure - the extra levator apr - has been suggested. this study aims to investigate both the oncological and the functional outcome of this method as compared to the traditional apr. method: all swedish patients undergoing abdominoperineal resection for rectal cancer 2007-2009 will be analysed regarding operative technique (traditional or extra levator resection). data on all patients regarding pre op tnm classification, pathological report and local recurrence will be collected from the swedish rectal cancer registry. a validated qol form will be sent to each patient to further investigate the functional outcome, health economy and quality of life 2-4 years postoperatively. data will be analysed regarding 3 year recurrence rate (primary endpoint) as well as functional result and qol (secondary endpoints) in the two different groups - i.e traditional and extra levator apr.

Eligibility criteria:
inclusion criteria: * rectal cancer operated with apr 2007-2009 exclusion criteria: * no informed consent

Keywords: rectal cancer apr