Kornimate/medical-research-clean huggingface dataset:
reliability, validity, and cross-cultural adaptation of the turkish version of the victorian institute of sports assessment for gluteal tendinopathy (visa-g) questionnaire

Conditions: Greater Trochanteric Pain Syndrome of Both Lower Limbs; Gluteal Tendinitis

Summary: the purpose of this study was to investigate adaptation, validity, and reliability of the turkish version of the victorian institute of sports assessment for gluteal tendinopathy (visa-g) questionnaire.

gluteal tendinopathy, also known as greater trochanteric pain syndrome, interferes with physical function and sleep, and is characterized by pain and tenderness over the greater trochanter.clinical risk factors for the development of this condition include advanced age, female gender, back pain, overweight / obesity, poor abductor hip function, altered gait parameters, and psychological distress. the victorian institute of sports assessment for gluteal tendinopathy (visa-g) questionnaire has recently designed as a patient-reported condition-specific outcome measurement tool to assess disability due to tendinopathy. visa-g is scored between 0 and 100 (a higher score is expected) and consists of eight items covering three main areas (pain, function, and current activity level). visual analog score for pain (0-10), the effect of pain on weight-bearing activities (0-30), and difficulty and / or function-related stairs use, including lying on the symptomatic side (0-10), climbing ramps (0-10), standing up without sitting (0-10), home or garden work (0-10) and regular exercise (0-10), physical activity and sports participation (0-10) are evaluated. the study is planned with 40 individuals with gluteal tendinopathy. after questioning the sociodemographic characteristics of the individuals, the patients will be asked to fill in visa-g, short form-36, international physical activity questionnaire, numeric rating scale, oswestry disability index, oxford hip score and modified harris hip score.test-retest will be re-applied to those of the same individuals who can be reached after 1 week. the results will be analyzed using the spss version 22.0 computer package program.

Eligibility criteria:
inclusion criteria: * trochanteric bursitis and/or gluteal tendinopathy, * lateral hip pain, * pain on palpation of the greater trochanter, * history of pain when lying on the ipsilateral side or during weight-bearing activities, aggravated by activity for more than 3 months. exclusion criteria: * hip osteoarthritis, * systemic inflammatory disease such as rheumatoid arthritis, * lumbar spine nerve root findings, * history of lumbar spine or ipsilateral hip joint surgery, * osteogenic disease such as paget's disease, * corticosteroid injection to the ipsilateral hip in the past 3 months, * hip surgery.

Keywords: validity reliability greater trochanteric pain syndrome gluteal tendinopathy
validation of the sd-icu. a risk assessment tool of unplanned icu readmission

Conditions: Critical Illness

Summary: in a recent study, which included 845 patients that at the time of icu discharge had at least one risk factor for readmission, the investigators' group developed a new readmission risk score in the icu, safe discharge from icu (sd-icu), using parameters easily and routinely measured in icu: the charlson comorbidity (icc), the tiss-28 (therapeutic intervention scoring system - 28), the length of stay in icu and age. through roc curve analysis, the investigators found that patients with a score above 14.5 had a high probability of readmission. the objective of this study is to validate the safe discharge from icu (sd-icu) score as a tool to predict unplanned readmissions to the intensive care unit. all adult patients discharged from a 37 bed general icu from april 2014 to march 2015 will be included in the study. the sd-icu score is routinely calculated at the time of discharge from the icu. patients will be divided into two groups: those with sd-icu score\> 14.5 (group 1) and those with a score equal to or less than 14.5 (group 2). the two groups will be compared with respect to the frequency of unplanned readmissions. stepwise, multivariate logistic regression will be used to investigate the association between the risk factors for readmission used in sd-icu score and icu readmission as outcome.


Eligibility criteria:
inclusion criteria: * adult patients discharged from a general icu exclusion criteria: * patients under 18 years old * those that were not candidates for icu readmission (interhospital and home care transfer)

Keywords: risk score readmission icu
aerosol transmission of severe acute respiratory syndrome coronavirus of coronavirus disease 2019

Conditions: Coronavirus Disease (COVID-19)

Summary: there is little information on the characteristics of airborne severe acute respiratory syndrome coronavirus containing aerosols, their concentration, or their infectivity.the aim was to determine airborne severe acute respiratory syndrome coronavirus transmission, their infectivity in different areas such as patient's room and in medical staff área.

the corona virus disease 2019 is rapidly spreading throughout the world. aerosol is a potential transmission route. the transmission of severe acute respiratory syndrome coronavirus in humans is thought to be via at least 3 sources: 1) inhalation of liquid droplets produced by and/or 2) close contact with infected persons and 3) contact with surfaces contaminated with severe acute respiratory syndrome coronavirus. there are many respiratory diseases spread by the airborne route such as tuberculosis, measles and chickenpox. several studies suggested that airborne spread may have played an important role in the transmission of that disease. at present, there is little information on the characteristics of airborne severe acute respiratory syndrome coronavirus containing aerosols, their concentration, or their infectivity. the aim was to determine airborne severe acute respiratory syndrome coronavirus 2 transmission, their infectivity in in different areas such as patient's room and in medical staff area. methods cross sectional study of samples from environmental of patient´s room, and medical staff area. samples will be taken of air using microbial air monitoring systems, and from different surfaces of patient's room and medical staff area, such as computers, mouse and personal protective equipment using cotton swabs. viral rna will be determined using real-time-polymerase-chain reaction. in positive samples infectiveness will be determined by cell culture under biosecurity conditions. statistical analysis will be performed to determine prevalence of positive samples and positive cell culture whit stata version 15.1. informed consent will be obtained from all participants

Eligibility criteria:
inclusion criteria: * adults 18 years and more, with diagnoses of covid-19 96 hours since the beginning of symptoms. * medical staff, nurses and/or physician taking care of patient whit covid-19 exclusion criteria: * unwilling to give informed consent

Keywords: severe acute respiratory syndrome coronavirus 2 airborne transmission
comparison of two vaginal mesh kits in the management of vaginal prolapse

Conditions: Vaginal Prolapse

Summary: our study is a non-randomized prospective study compared two groups matched for anterior/apical pop-q grade: 84 received elevate ant™ single-incision mesh (group a) and 42 perigee™ transvaginal mesh (group b). the study hypothesis was that the elevate ant™ mesh would provide better apical correction than the perigee™ mesh. one- and 2-year follow-up comprised anatomic assessment (pop-q) and qol (pfdi-20, pfiq-7, pisq-12). success was defined as 2-year pop-q ≤1. secondary endpoints were function and complications.


Eligibility criteria:
inclusion criteria: * symptomatic patient presenting with pop-q grade ≥3 anterior or apical prolapse

Keywords: vaginal prolapse, mesh kit, anatomic assessment, quality of life
rapid acupuncture treatment for post-traumatic stress disorder

Conditions: PTSD

Summary: the summary of this research study is to test the effectiveness of a rapid "rescue" acupuncture technique as a non-pharmacologic alternative treatment for the reduction of post-traumatic stress disorder (ptsd) symptoms in affected individuals as a means to improve warfighter health and enable a more rapid return to duty, especially in austere environments. patients will receive acupuncture as a research-related course of treatment for ptsd. the pcl-5 questionnaire will be used to assess the presence and severity of ptsd symptoms. a pcl-5 questionnaire will be administered at the beginning of the first treatment of "rescue" acupuncture and after the last treatment. following the acupuncture treatment, a pcl-5 questionnaire will be initiated at the beginning of the first week of treatment and the end of the second week of treatment at the participating mental health clinic (pmhc).

"the objective is to treat three arms of ptsd patients: arm 1: newly untreated diagnosed ptsd patients referred from a participating mental health clinic (pmhc) who have not yet received any ptsd treatment for a 2-week therapy of ""rescue"" acupuncture (six 30 minute sessions monday, wednesday, and friday); arm 2: newly diagnosed ptsd patients referred from the pmhc but already placed on pharmacological therapy (i.e. prazosin, ssri, sedative, etc.) prior to their enrollment in the pmhc; and arm 3: newly diagnosed ptsd patients with or without medications referred to pmhc but have a mild traumatic brain injury that does not impede their judgment ability. arms 2 and 3 will follow the same ""rescue"" acupuncture program as arm 1. a pcl-5 questionnaire will be administered prior to and after ""rescue"" acupuncture. arms 1, 2, and 3 patients will return to the pmhc (after 2 weeks of ""rescue"" acupuncture) to start or continue pharmacological and/or non-pharmacological therapy(s) and will also be evaluated by a pcl-5 questionnaire at the start and after 2 weeks. statistical analysis of the pcl-5 questionnaire will compare the three arms together as to whether acupuncture is a benefit or not to the patient following therapies received for 2 weeks in the pmhc. the lowering of the pcl-5 symptomatic questionnaire score is a favorable indication of a benefit.

Eligibility criteria:
inclusion criteria: active duty and retired military referred from a participating mental health clinic - exclusion criteria: pregnancy participated in a form of acupuncture in the last 3 months

Keywords: acupuncture ptsd pcl-5 questionnaire
forecast number of covid-19 cases worldwide

Conditions: Covid-19

Summary: coronavirus disease-19 (covid-19) had an unprecedented effect on both nations and health systems. time series modeling using auto-regressive integrated moving averages (arima) models have been used to forecast variables extensively mainly in statistics and econometrics. the investigators aimed to predict the total number of cases for covid-19 using arima models of time-series analysis.

coronavirus disease 19 (covid-19) is an infectious disease initially defined in december 2019 before becoming pandemic. respiratory disease is the main form of disease causing acute respiratory distress as the main cause of death. increased number of cases worldwide had put an enormous load on public health resulting lockdowns, quarantines and curfews. predicting number of cases is hard as the increment of cases between communities differ. time series had been used in different fields of science to predict, such as signal processing, mathematical finance, weather prediction. in medicine, time series analysis were used in number of admitted patients to hospitals. aim of this study is to predict the total number of covid-19 cases worldwide using time series anaylsis.

Eligibility criteria:
inclusion criteria: * confirmed case of covid-19 exclusion criteria: * cases not reported

Keywords: covid19, forecasting
investigate the safety and tolerability of olaparib tablet in japanese patients with advanced solid malignancies

Conditions: Cancer; Advanced Solid Malignancies

Summary: the objective of this study will be to investigate the safety and tolerability of olaparib tablet when given orally to japanese patients with advanced solid malignancies. in addition, the pharmacokinetic profile, mtd (if possible) and efficacy of olaparib will be investigated.

mtd - maximum tolerated dose

Eligibility criteria:
inclusion criteria: * subjects diagnosed with advanced solid malignancies who are refractory to standard therapies or for which no standard therapy exists. * subjects who have overall good overall general condition. * subjects who agree to hospitalisation from starting olaparib to multiple dose period at day 15. * evidence of non-childbearing status for women of childbearing potential, or postmenopausal status. * subjects who have at least one lesion (measurable and/or non-measurable) that can be accurately assessed by ct/mri at baseline and follow up visits exclusion criteria: * subjects who received any previous treatment with a parp (poly adenosine diphosphate-ribose polymerase) inhibitor, including olaparib. * subjects receiving inhibitors of cyp3a4 (cytochrome p450 3a4). * subjects with symptomatic uncontrolled brain metastases. * subjects with myelodysplastic syndrome/acute myeloid leukaemia. * subjects with a known hypersensitivity to olaparib or any of the excipients of the product.

Keywords: cancer tumour solid malignancies
correlation of location of abdominal tenderness with acute ct abnormalities in emergency department patients

Conditions: Abdominal Pain

Summary: to determine the correlation between the region of abdominal tenderness determined by the examining physician and the location of acute pathology diagnosed on abdominal ct. we hypothesize that the acute pathology diagnosed by ct will lie within the region marked on the abdominal wall by the examining physician prior to ct.


Eligibility criteria:
inclusion criteria: * all consecutive emergency department patients undergoing abdominal ct for non-traumatic abdominal pain and tenderness will be prospectively enrolled, with the following exceptions. for study purposes, "abdominal pain and tenderness" is defined as pain and tenderness to direct palpation in the region anterior to the mid-axillary line bilaterally, and extending from the costal margins to the inguinal ligaments. consequently, patients undergoing ct for indications such as isolated vomiting, fever without source, staging of malignancies, isolated flank pain or suspected renal colic, or other indications that do not meet the above definition will not be enrolled. exclusion criteria: * pregnant women do not routinely undergo abdominal ct due to radiation concerns and will be excluded from the study. * patients with altered mental status or altered abdominal sensation (due to neurological conditions such as paraplegia) that may prevent assessment of the location of abdominal tenderness will be excluded. * preverbal children will be excluded as they rarely undergo ct and will be unable to indicate the region of maximal tenderness.

Keywords: emergency acute nontraumatic abdominal pain tenderness ct scan radiation diagnosis
clinical investigation on the efficacy and safety of relizema cream in paedriatric patients

Conditions: Atopic Dermatitis

Summary: the scope of this multicenter, double blind, randomized, vehicle-controlled clinical investigation is to evaluate and confirm the performance and safety of the relizema cream in the improvement of the dermatitis severity in paediatric patients. the disease severity will be clinically measured through the investigator global assessment (iga) after 42 days of treatment.

this is a pre market study to evaluate and confirm the performance of the relizematm cream in the improvement of the dermatitis severity, assessed through a clinical parameter, the investigator's global assessment (iga) at baseline and at visit 3, compared to vehicle. to evaluate the performance of the relizematm cream, compared to placebo in the eczema improvement through the easi. the safety objectives is to evaluate the local and general tolerability of relizema cream compared to placebo.

Eligibility criteria:
inclusion criteria: * release of the written informed consent obtained prior to any study-related procedures, by both the parents/the guardian; * male and female infants, children, adolescent aged between 6 months and 16 years, inclusive; * presence of atopic dermatitis (ad) of mild-moderate severity: * iga score 2 (=mild) or * iga score 3 (=moderate) * patients with a baseline score for itch at least 4 on the nrs * patients/parents/guardian able to comprehend the full nature and the purpose of the investigation, and able to comply with the requirements of the entire investigation (including ability to attend the planned visits according to the time limits), based on investigator's judgement exclusion criteria: * severe dermatitis at inclusion; * pregnant and breastfeeding patients; * concomitant other skin disorders including skin infections; * use of antibiotics in the past 7 days; * history of congenital or acquired immunodepression; * immunologic or infectious disease (e.g. hepatitis, tuberculosis, hiv or aids, any typology of lupus, rheumatoid arthritis) which could place the patient at risk or interfere with study results; * use of any topic or systemic drug for dermatitis in the past 10 days; * use of any topic emollient product for dermatitis in the 2 days before study treatment start; * any systemic treatment or procedure that could influence dermatitis activity within the past 30 days (or 5 half-lives); * use of any corticosteroids, immunosuppressant drugs or immunotherapy within the past 30 days (or 5 half-lives); * use of oral antihistamines and antidepressants in the past 30 days; * patients with any other clinically significant or unstable concurrent disease or skin condition or general condition that, in the investigator's opinion, might interfere with the study evaluations; * allergy, sensitivity or intolerance to the components of the investigational device formulations ingredients; * concomitant or previous participation in other interventional clinical study in the past 3 months; * patients planning sun exposure or tanning booths or uv sources throughout the course of the study.

Keywords: cream paediatric patients
percutaneous endoscopic lumbar discectomy add by annuloplasty and nucleoplasty

Conditions: Lumbar Disc Herniation

Summary: recently, percutaneous endoscopic lumbar discectomy (peld) is also commonly performed for lumbar disc herniation. following discectomy, the relief of leg pain is common; however, the relief of back pain is less predictable. the association of back pain and lumbar disc herniation is still unclear. peld and annuloplasty (pelda) can relieve back pain associated with disc herniation as well as leg pain through decompression and thermal ablation of annular defects in selected patients. another problem that rapidly increasing go along with the growing number of microdiscectomies is directly proportional to the number of patients who undergo re-operations due to recurrences. the surgical treatment can be helpful in prevention of re-operations is nucleoplasty. endoscopic discectomy for lumbosacral herniation supplemented with nucleoplasty can reduce the recurrence and reoperation rates.


Eligibility criteria:
inclusion criteria: * primary single-level lumbosacral intervertebral disc herniation at the l4-l5 or l5- s1 level will perform surgical intervention of percutaneous endoscopic lumbar discectomy * all patients present with sciatica and back pain that will not improve with conservative treatment for a minimum of 6 weeks * all patients undergo plain radiographs, magnetic resonance imaging (mri) * the patients will require to have an obvious disc herniation that caused compression of a nerve root corresponding to the dermatomal distribution of the leg symptoms. exclusion criteria: * patients have foraminal, extra-disc herniation, multilevel disc herniation, spinal stenosis, spondylolisthesis, scoliosis, prior lumbar surgery, spinal infection, spinal tumor, and a history of hip or knee arthritis.
2.5 versus 5 minutes trial

Conditions: Hypotension

Summary: this is a randomized trial investigating the effect of oscillometric blood pressure monitoring at 2.5-minute intervals - compared to 5-minute intervals - on intraoperative hypotension. specifically, the investigators will test the primary hypothesis that oscillometric blood pressure monitoring at 2.5-minute intervals - compared to 5-minute intervals - reduces the time-weighted average mean arterial pressure below 65 mmhg in patients having non-cardiac surgery.


Eligibility criteria:
inclusion criteria: * ≥45 years * scheduled for elective non-cardiac surgery under general anesthesia * planned oscillometric blood pressure monitoring with an upper-arm cuff * american society of anesthesiologists physical status class ii or higher exclusion criteria: * emergency surgery * arm or shoulder surgery * pregnancy * preoperative blood pressure differences between the right and left arm of more than 20 mmhg * intraoperative invasive blood pressure monitoring * previous preoperative peripheral nerve injury (such as diabetic neuropathy, carpal tunnel syndrome, or cervical radiculopathy) * contraindication for continuous finger-cuff blood pressure monitoring (e.g., raynaud's disease, arterial-venous shunts, or cardiac assist devices)