Kornimate/medical-research-clean huggingface dataset:
a study to evaluate the efficacy, safety, and tolerability of bms-986278 in participants with idiopathic pulmonary fibrosis

Conditions: Idiopathic Pulmonary Fibrosis

Summary: the purpose of this study is to evaluate the efficacy, safety, and tolerability of bms-986278 in participants with idiopathic pulmonary fibrosis.


Eligibility criteria:
inclusion criteria * subjects with ipf aged ≥ 40 years at the time of signing the informed consent. * diagnosis of ipf within 7 years prior to screening that is supported by centrally read chest high-resolution computed tomography (hrct) obtained at screening and verification of usual interstitial pneumonia. * if on pirfenidone or nintedanib, participants must have been on a stable dose for at least 90 days prior to screening. * if not currently on pirfenidone or nintedanib, participants must not have received either of these medications within 28 days prior to screening. * women who are of childbearing potential must have a highly effective form of contraception and must provide a negative urine/serum pregnancy test. * men who are sexually active with women of childbearing potential agree to use male barrier contraception. exclusion criteria * history of stroke or transient ischemic attack within 3 months prior to screening. * participants who exhibit symptoms of heart failure at rest. * participants who have a current malignancy or a previous malignancy with less than 2 years free of recurrence or a biopsy that is suspicious for malignancy and the possibility of malignancy cannot be reasonably excluded following additional clinical, laboratory, or other diagnostic evaluations. * other protocol-defined inclusion/exclusion criteria apply.

Keywords: bms-986278 lpa1 antagonist ipf pulmonary fibrosis
application of vr-based working memory screening test

Conditions: Older Adults With Mild Neurocognitive Disorders; Older Adults With Non-communicable Diseases; Healthy Age-matched Older Adults

Summary: we propose to validate an interactive, immersive spatial memory test from the laboratory test. this vr-based working memory test (vrwmt) is a first-person, self-pacing game embedded within a virtual reality environment, the program is easily implemented with minimal instructions and no supervision that can be community-users friendly. it is specifically designed to assess rapid spatial working memory - a common deficit in all ncd subtypes. its ability to detect pathological models of dementia, age-related deterioration, and hippocampal dysfunction are well established in literature

the proposed research aims to study the ability of vrwmt to discriminate between older adults with known mild ncd, healthy age-matched older adults and participants with non-communicable diseases and to predict their deterioration in cognitive function over a period of 12 months. moreover, this study is to characterize and evaluate any concurrent validity between emergence of deterioration in the vrwmt and clinical tools of functional performance in older adults. additionally, the potential of inflammatory and metabolic dysregulation biomarkers to increase our ability to detect early ncd risk over and above the predictive validity of the vrwmt. the study findings will bring both social and clinical significance to ageing and ncd research. the combination of behavioural and biomarkers of pathological significance offers an innovative approach that potentially addresses the limitations intrinsic to either measure alone.

Eligibility criteria:
inclusion criteria: * the ability to understand verbal and written chinese instructions * the ability and willingness to provide informed consent and sign the relevant document. exclusion criteria: * a history of substance abuse including alcohol, drugs, or any medication/substances indicative of chronic abuse; * participants with major ncd.

Keywords: cognitive function screening
using smart phone technology to support hiv medication refill adherence in virginia

Conditions: Hiv; Adherence, Medication

Summary: the purpose of this study is to pilot a mobile health intervention, originally designed for hiv retention in care, for use in aiding patients with medication refills. the study will implement the positivelinks rx app with the henrico health department. the study will assess user engagement and satisfaction with the app as well as preliminary impact on patient refill compliance.

the study will enrolled provider and patient participants at the henrico health department in virginia who either receive or provide medication refills through the aids drug assistance program (adap). patient participants will be provided access to a mobile app that allows them to track their mood, stress, and medication adherence, access an anonymous online community, securely message providers, and receive medication refill alerts. provider participants will be able to view the information entered by enrolled clients, securely message clients, and track medication refill processes. study participants will be asked to provide feedback on usability, utility, impact, and effectiveness of the program. additional assessments will evaluate for impact on medication refill adherence and patient-provider communication.

Eligibility criteria:
patient inclusion criteria: * currently picking up of receiving medications through adap from the henrico health department; able to read in english; able to speak english; able to sign informed consent provider inclusion criteria: * current henrico health department employee working with the adap pharmacy; able to read in english; able to speak english; able to sign informed consent exclusion criteria: * severe cognitive impairment that interferes with a subjects ability to consent; non-english speaking; prisoners
correlation between cervical spine muscle disorders and the occurrence of symptoms of temporomandibular joint dysfunction

Conditions: Temporomandibular Joint Disorders

Summary: this study evaluated the correlation between the occurrence of disorders of selected muscles of the cervical spine and the occurrence of symptoms of tmj dysfunction

the examination includes personal questionnaire, physical examination and an algometer measurement on the upper fibers of the trapezius, levator scapula, sternocleidomastoid and rectus capitis posterior major to define pressure sensitivity of neck muscles and define is there a correlation between the occurrence of disorders of selected muscles of the cervical spine and the occurrence of symptoms of tmj dysfunction.

Eligibility criteria:
inclusion criteria: * age 19-25 years * relatively good health * consent to participate in the research experiment exclusion criteria: * people with skin problems in the head and neck area that that made the examination impossible * previous head and neck surgeries and traffic injuries * coagulation disorders or taking medications that reduce blood coagulability * venous thrombosis in the neck area * sensory disorders * dislocation of the jaw in the past * taking painkillers 12 hours before starting the study * being under orthodontic or physiotherapeutic treatment focused on tmj dysfunctions

Keywords: tmj disorders pressure sensitivity algometer young adults myofascial pain
atropine or ephedrine pretreatment for preventing bradycardia in elderly patients

Conditions: Anesthesia, Spinal; Dexmedetomidine; Bradycardia

Summary: spinal anesthesia is widely used for lower extremity surgery, and sedation is often required during surgery. for sedation, propofol, midazolam and dexmedetomidine are frequently used. dexmedetomidine is a highly selective alpha 2 receptor agonist, and has sedating and analgesic effect. compared with propofol and midazolam, it has little or no respiratory inhibition and hemodynamically stable. it also has the effect of reducing delirium in the elderly. dexmedetomidine has also been reported to prolong the duration of sensory and motor blockade effects of spinal anesthesia. however, several studies have reported that administration of dexmedetomidine in spinal anesthesia increases the incidence of bradycardia. in a study of healthy young adults, concurrent administration of atropine with dexmedetomidine in spinal anesthesia significantly reduced the frequency of bradycardia requiring treatment. however, in elderly patients, it is often reported that there is little response to atropine in bradycardia, and ephedrine is more effective in treating bradycardia than atropine in the elderly. the investigators therefore compared ephedrine and atropine as pretreatment to reduce the incidence of bradycardia when using dexmedetomidine as a sedative in elderly patients undergoing spinal anesthesia.


Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) classification i-ii * undergoing orthopedic surgery under spinal anesthesia exclusion criteria: * contraindication for spinal anesthesia * atrial fibrillation, atrial flutter * cardiac valve disease * neurologic disease * initial systolic blood pressure in operating room \> 160mmhg
effect of acp on surgical repair of rotator cuff tears

Conditions: Rotator Cuff Tears

Summary: the purpose of this study is to determine if autologous plasma (acp) is beneficial for better and faster healing following an arthroscopic repair of the rotator cuff.

the shoulder joint, specially the rotator cuff, is one of the most complicated joints of the human body. if the tendon has to be fixed at the bone during surgery, the weak point in obtaining a successful surgery is the fixation of the tendon at the bone insertion site. tendon belongs to the bradytrophic tissue conditional on the reduced blood flow, deep mitosis rate and lowered healing potential. we can boost the healing process with a selective use of prp (platelet rich plasma). in this process, the healing site is delivered with an elevated concentration of thrombocytes and also growth factors which are constituent parts of them. in this study, we will test the arthrex® double syringe system. with this system it is possible to obtain acp (autologous conditioned plasma) in one centrifugation step. the supernatant contains a concentration of thrombocytes which is twice as high as in the native blood. the concentration of the growth factors is 5-25x higher according to this. we also want to test if one application of acp is enough to get a short- and long-term benefit in healing following a rotator cuff tear.

Eligibility criteria:
inclusion criteria: * arthroscopic rotator cuff reconstructions of degenerative or traumatic full thickness rotator cuff tears (supraspinatus and/or infraspinatus tendon) performed by dr. flury and dr. schwyzer * suture bridge technique * no pregnancy at the date of the surgery for women of childbearing potential * signed consent form exclusion criteria: * partial reconstruction of the rotator cuff (pasta) * open reconstruction * tendon transfer (latissimus dorsi or pectoralis major) * revision surgery * omarthrosis (level ≥ 2 samilson \& prieto) * systemic arthritis * rheumatoid arthritis * diabetes (insulin treated) * requiring surgery in reconstruction of the subscapularis tendon * progressive fat inclusion (fatty infiltration of the rotator cuff musculature goutallier level iv * acute or chronic infection * pathological bone metabolism * insufficient perfusion in the affected arm * neuromuscular disease in the affected arm * non compliance of the patient * disorders which handicap or inhibit the patient to follow the orders of the clinical testers

Keywords: rotator cuff tears acp
75 or 150 mg clopidogrel maintenance doses following pci (isar-choice-2)

Conditions: Coronary Disease

Summary: the purpose of the study is to test whether an increase of the maintenance dose of clopidogrel from 75 to 150 mg per day results in an additional suppression of adp-induced platelet aggregation

in patients treated with coronary stents clopidogrel therapy is usually initiated with a 300 to 600 mg loading dose. in the credo trial it was shown that a 300 mg loading dose results in a reduction of ischemic events after percutaneous coronary intervention (pci) if given 6 hours prior to the procedure. an antiplatelet effect similar to that achieved by chronic therapy with 75 mg/day is reached within 2 hours when the high 600 mg loading is administered. the 600 mg loading dose has been shown to be safe and effective in preventing thrombotic events following coronary stent implantation. recently, it was shown that in patients with stable angina and administration of the 600 mg loading dose at least two hours prior to pci concomitant therapy with a gp iib/iiia antagonist does not result in a further reduction of the incidence of thrombotic events. in contrast to a number of investigations with different loading doses, no trials have been performed comparing different clopidogrel maintenance doses. recently, it was shown that administration of a 600 mg loading dose in patients already on chronic clopidogrel therapy (75 mg/day) results in an additional significant increase in inhibition of adenosine diphosphate (adp-) induced platelet aggregation. therefore, it is possible that an increase of the clopidogrel maintenance dose in patients with chronic clopidogrel therapy also results in a more pronounced inhibition of platelet aggregation.

Eligibility criteria:
inclusion criteria: * patients with chronic aspirin therapy who are treated with percutaneous coronary intervention at least 2 hours after administration of a 600 mg loading dose of clopidogrel exclusion criteria: * major alterations of blood count (particularly platelet count \< 100x10\^9/l, haemoglobin \< 10 mg/dl * recent bleeding diathesis * presence of a hematologic or malignant disorder * oral anticoagulation with coumarin derivates * use of glycoprotein (gp) iib/iiia antagonists during the intervention or during the preceding 14 days * therapy with clopidogrel within the last 28 days
the effects of long-term mask use in the pandemic period

Conditions: COVID-19

Summary: various restrictions have been made all over the world due to coronavirus pandemics. in addition to situations such as social isolation and hygiene, the use of masks is among these rules. in addition to the protection it provides, the use of masks causes some negative situations in individuals. for this reason, the aim of our study is to examine the effects of long-term mask use on temporomandibular dysfunction, headache and fatigue.


Eligibility criteria:
inclusion criteria: * over 18 years * able to read and understand * volunteer to participate exclusion criteria: * malignity history * head/face surgery history

Keywords: mask temporomandibular joint disorders headache fatigue
image - navigated resection of lung nodules

Conditions: Lung Diseases

Summary: this is an open label study lung nodules that are either cancer or non-cancer and who are eligible for surgical resection. patients will undergo their surgery with the help of the lung resection marker locator kit which will assist the surgeon in both the location and resection of the lung nodule under real-time guidance.


Eligibility criteria:
inclusion criteria: 1. males or females aged 21 years or older as it is extremely rare for younger people to be at risk for lung cancers. 2. be deemed candidates for the lung resection surgery, which will be determined by their treating thoracic surgeon (also a physician investigator) 3. have lesions that are nodules/ggo or other abnormal opacity that can be accurately measured in at least one dimension using conventional techniques 4. seen at bwh thoracic surgery outpatient clinics or as inpatient (note: subjects will be formally consented to the study at bwh only) exclusion criteria: 1. female subjects pregnant or breastfeeding 2. subjects with a pacemaker or equivalent devices (aicd) due to the use of electromagnetic tracking generator. 3. patients who are not scheduled for lung surgery -

Keywords: lung nodule lung cancer lung mass
gait classification in children with cerebral palsy, a reliability study

Conditions: Cerebral Palsy

Summary: the goal of this observational study is to assess whether gait classification patterns can be reliably obtained from video recordings in comparison with three-dimensional kinematic data. the main questions it aims to answer are: are gait classifications from video recordings reliable between raters? are gait classifications from video recordings valid in comparison with three-dimensional kinematic data? gait analysis data from participants who visited the gait lab in the karolinska hospital will be used for this purpose.

current retrospective observational study aims to assess the reliability and validity of gait pattern classification systems in ambulatory children with cp. gait classification is often performed using kinematic gait data obtained via a three dimensional (3d) data captured in a specialized gait lab using infra-red cameras. however, not all hospitals and clinical centers have access to such a specialized gait lab, and therefore often use video recordings as an alternative for gait classification. it is currently not known whether such a classification based on solely video recordings is equally reliable in comparison with kinematic gait data. for this purpose, current study aims to assess the reliability and validity of video recordings to classify children with cp according to predefined gait classifications. sagittal plane video recordings during barefoot walking in children with cp will be used to classify the study participants into seven different gait classification patterns. for reliability, inter-rater reliability between raters scoring the video recordings will be assessed. to evaluate whether video recordings could serve as a valid alternative for kinematic gait data, the agreement between the classifications from the video recordings and the kinematic data additionally will be assessed.

Eligibility criteria:
inclusion criteria: * main diagnosis of spastic cerebral palsy * age 3 to 18 at the time of gait analysis * availability of barefoot walking data collected at the karolinska hospital gait lab * written informed consent of both parents to use the clinically collected data as research data exclusion criteria: * main diagnosis of dyskinetic or ataxic cerebral palsy * no barefoot walking trials available * no kinematic data available * btx-a injections 6 months prior to gait analysis * orthopaedic surgery one year prior to gait analysis

Keywords: cerebral palsy gait pattern classification
impact of adipose tissue repartition on the time course of vascular dysfunction - the numevox cohort

Conditions: Metabolic Diseases; Sleep Apnea; Atherosclerosis

Summary: the numevox cohort is intended to follow-up the macro and microvascular dysfunction in relation to adipose tissue repartition in patients with metabolic syndrome associated to liver steatosis, sleep apnea. duration of the follow-up is 3 years for each patient entering the cohort.


Eligibility criteria:
inclusion criteria: * informed consent * age \> 18 years old * suspected of metabolic syndrome * affiliated to french social health care exclusion criteria: * age \< 18 years old * pregnancy * no informed consent * not eligible for the study (no ms, cancer)

Keywords: fatty liver adipose tissue
entire papilla preservation technique with and without biomaterials in the treatment of isolated intrabony defects

Conditions: Periodontal Diseases

Summary: the aim of this study is to investigate the clinical efficacy of entire papilla preservation technique with and without the adjunct of amelogenins (emd) and bone substitutes.

the present study is designed as a single-centre, parallel group, randomized, controlled clinical trial comparing the efficacy of epp with or without biomaterials. each patient will contribute with a single intrabony defect. three months after completion of initial periodontal therapy, all the experimental sites will be accessed with the "epp" technique (aslan et al., 2017a) and carefully debrided. edta gel will be applied on the instrumented root surfaces. a combination of emd and deproteinized bovine-derived bone substitute will be applied in the test group (epp emd + bs), while the control group (epp) will not receive any regenerative biomaterial. patients will be enrolled in a stringent maintenance programme with recalls on a weekly basis for the first month and then monthly controls for professional tooth cleaning up to 1 year. clinical parameters will be recorded immediately before regenerative surgery (baseline) and 12 months after the regenerative periodontal surgery.

Eligibility criteria:
inclusion criteria: * systemically healthy * clinical diagnosis of advanced periodontitis * having one isolated intrabony defect with probing depth (pd) ≥7 mm, clinical attachment level (cal) ≥8 mm and at least 4 mm intrabony component involving predominantly the interproximal area of the affected tooth. * full-mouth plaque score (fmps) ≤20%. * full-mouth bleeding score (fmbs) ≤20%. exclusion criteria: * smokers * patients with known systemic diseases such as diabetes and cardiovascular diseases or using medications that affect periodontal tissues, pregnant or lactating women * one-wall intrabony defects * defects that involve buccal and lingual sites * presence of inadequate endodontic treatment and/or restoration in the relevant teeth.
adapting lfi for melioidosis

Conditions: Melioidosis

Summary: towards the goal of reducing melioidosis, this study will help clinicians in sarawak to diagnose and understand the causes and risk factors for melioidosis. the data will help the clinicians to provide faster test results and better clinical care. the investigator's laboratory efforts will supplement available diagnostics by adding a new, easier-to-use test involving lateral flow immunoassay to rapidly detect burkholderia pseudomallei, a bacterium causing melioidosis. the study aims to study up to 400 patients with melioidosis-like symptoms who are admitted to kapit hospital, sarawak, malaysia. no participants will be enrolled from other sites. the study will also examine the demographic, behavioral and occupational risk factors associated with hospital admissions to understand any existing associations between these variables and melioidosis prevalence.


Eligibility criteria:
inclusion criteria: * admitted to kapit hospital * fever more than 3 days and one or more of the following: * enlarged cervical, inguinal or axillary lymph nodes (greater than 3 cm in diameter), painless adenopathy or lymphadenitis or lymph node abscesses * one or both sides glands involvement such as tender swelling over medial aspect of the lower eyelid of the lacrimal glands; submandibular glands, parotic glands * bedside scan with splenic or liver hypoechoic lesion (less than 2cm in diameter) * pneumonia not responding to 48 hours of first line antibiotics * one or more joint pain with swelling * purplish vesicle or bullae mainly over the lower limbs, may resulting in ulcer after rupture * deep seated abscess or brain abscess or genitourinary abscess or osteomyelitis * severe sepsis patient with or without shock and/or with multiorgan involvement exclusion criteria: * have a clear alternative diagnosis other than melioidosis by a trained health care professional at the kapit hospital * have already been treated for melioidosis (e.g. received antibiotics before the start of the study) * are younger than 6 months of age

Keywords: lateral flow immunoassay validation