Kornimate/medical-research-clean huggingface dataset:
effects of virtual reality-based balance training compared to conventional balance training to reduce risk of fall in patients with diabetic peripheral neuropathy: a randomized control trial

Conditions: Diabetic Peripheral Neuropathy; Balance; Fall Risk

Summary: the objective of this study is to determine the effects of virtual reality based balance training compared to conventional balance training to reduce risk of fall in patients with diabetic peripheral neuropathy in terms of fall and gait parameters. the study is a non-blinded randomized control trial, consisting of 2 groups. the study will be conducted at fauji foundation hospital and foundation university islamabad. a calculated sample of 30 subjects will be selected via non-probability convenience sampling technique followed by randomization into two groups using envelope method. after cbrc registration, ethical approval is obtained from erc fumc. individuals fulfilling the inclusion criteria is selected, followed by written informed consent after explaining the study purpose. participants is then be randomly allocated to one of the 2 groups. at the baseline, fall efficacy scale (fes), activity-specific balance confidence (abc), time up and go test and dynamic gait index (dgi) are assessed. control group is provided with conventional balance training. treatment group is provided with the virtual reality (wii fit) based balance training. exercise training is performed thrice a week on alternate days for a total duration of 18 sessions over 06 week. all outcome measurements would be performed before and then after the 6-weeks intervention period. data will be entered and analyzed on spss v. 22.


Eligibility criteria:
inclusion criteria: * age: 40 years and above * medical diagnosis of diabetes under regular medication control and diabetic peripheral neuropathy (dpn) confirmed * independent community ambulatory individuals * intact cognition (mmse \> 24) exclusion criteria: * other neurological conditions i.e. dementia, parkinson disease, spinal cord injury or stroke. * severe visual impairment, musculoskeletal disorders, unhealed plantar ulceration, lower limb amputation, poor cardiopulmonary function or other disease that affects walking ability or any other disease due to which individuals are unable to walk without assistance. * any other condition associated with high risk of fall. * inability to follow simple instructions.

Keywords: diabetic peripheral neuropathy (dpn) peripheral nervous system disease hyperglycemia-induced neuropathy neuropathic pain sensory disorder motor neuron disease metabolic disease blood glucose regulation disorders hyperglycemia small fiber neuropathy, virtual reality based balance training conventional balance training balance rehabilitation fall prevention intervention
zevalin® followed by rituxan® maintenance in previously treated low grade non-hodgkin's lymphoma

Conditions: Lymphoma, Non-Hodgkin; Lymphoma, Low-Grade

Summary: the purpose of this study is to determine the safety and effectiveness of a treatment regimen using zevalin® plus rituxan® for patients who have low grade non-hodgkin's lymphoma (nhl) or relapsed non-hodgkin's lymphoma and have been previously treated. this study will use an experimental scheduling regimen. no chemotherapy will be used in this study.

the objective of this study is to determine overall response rate, event-free survival, time-to-progression, time-to-next-therapy, and freedom-from-relapse in patients with low-grade lymphoma in first or second relapse treated with zevalin followed by 2 years of rituxan maintenance therapy in a multicenter, community-based setting, as well as evaluate relative response rates in populations with and without prior rituximab therapy, in first versus second relapse, and with and without bulky (\> 5 cm in greatest diameter) disease. to meet the initial trial enrollment goal of 300 patients over two years, 42 total sites were activated. the study has subsequently closed to accrual. currently 8 sites remain active to follow the 12 subjects enrolled in the past year.

Eligibility criteria:
inclusion criteria: * follicular non-hodgkin's lymphoma including sll in first or second relapse. * no anticancer therapy for three wks (six wks if nitrosourea or mitomycin c); not rituximab refractory. * age \>= 18 years, not pregnant or lactating. * expected survival \>= 3 mths; ps 0, 1, or 2. * anc \>= 1,500/mm3, platelet counts \>= 100,000/mm3. * total bilirubin \> 2.0 mg/dl, creatinine \> 2.0 mg/dl. * total lymphocyte count \< 5,000/mm3 for sll. * \<25% bone marrow involvement with lymphoma. exclusion criteria: * prior abmt or asct, hypocellular or marked reduction in bone marrow precursors, or history of failed stem cell collection. * bulky areas of disease more than 10 cm in diameter. * patients with cll, cns, or mantle cell lymphoma. * hx of hiv/aids related lymphoma, hepatitis b or c. * prior radioimmunotherapy or xrt to \>25% of active bone marrow. * g-csf or gm-csf within 2 wks, pegylated g-csf within 4 wks of treatment

Keywords: radioimmunotherapy antigens, cd20
the effect of laser power and fiber traction speed on the outcomes of endovenous laser ablation

Conditions: Varicose Veins

Summary: a multicenter clinical randomized controlled trial, comparing of three different regimens of endovenous laser ablation with equal linear endovenous energy density in patients with insufficiency of the great saphenous vein (gsv). the linear endovenous energy density (leed) is the main value for standardization evla. from many studies, it is known the optimum value of the leed. however, the same leed may be obtained by varying the ratio between the laser power and the fiber pullback speed. power decrease can allow to reduce the incidence of adverse effects of endovenous laser ablation, but keep high efficiency.


Eligibility criteria:
inclusion criteria: patients over 18 years old insufficiency of the gsv measured with ultrasound imaging, reflux \> 0.5 sec no prior treatment of the insufficient gsv informed consent exclusion criteria: acute deep or superficial vein thrombosis agenesis of deep vein system vascular malformation or syndrome post-thrombotic syndrome, occlusive type pregnancy phlebectomy on the thigh immobility allergy to lidocaine arterial insufficiency

Keywords: endovenous laser ablation radial fiber linear endovenous energy density 1470 nm occlusion rate
perioperative three dimensional right ventricular function

Conditions: Heart Diseases

Summary: this study addresses the influence of anesthesia induction, ventilation and influence of cardiac surgical procedures and cardio-pulmonary-bypass on right ventricular function. influence on patient outcome is also studied. three dimensional echocardiography is applied.


Eligibility criteria:
inclusion criteria: * informed consent given * cardiac surgical procedure * left sided cardiac surgery or bypass surgery, ascending aortic surgery, assist device implantation exclusion criteria: * pregnant patients * contraindication for transesophageal echocardiography
wireless stimulation endocardially for cardiac resynchronization therapy

Conditions: Heart Failure; Ventricular Dysfunction; Cardiomyopathy

Summary: the wics-lv system is an alternative means to providing left ventricular stimulation for cardiac resynchronization therapy (crt). the purpose of this study is to evaluate the safety and performance of the wics-lv system in patients with indications for crt.

eligible patients will undergo an acoustic window assessment using transthoracic echocardiography. patients with adequate acoustic windows will undergo implantation of the wics-lv system. patients will undergo evaluations pre-hospital discharge, and at one month, 3 months, and 6 months post implantation. extended follow-up will be obtained via a registry at 1, 2, 3, 4, and 5 years post implantation.

Eligibility criteria:
inclusion criteria: patients with standard indication for crt based upon the most recent guidelines and meeting criteria for one of these three categories: 1. patients with previously implanted pacemakers or icd's and meeting standard indications for crt - referred to as "upgrades" 2. patients in whom attempted coronary sinus lead implantation for crt has failed - referred to as "untreated" 3. patients with previously implanted crt device, not responding to crt (no change or worsening of symptom or nyha functional class after 6 months of treatment confirmed by investigator) - referred to as "non-responders" exclusion criteria: 1. inability to comply with the study follow-up or other study requirements 2. contraindication to heparin 3. contraindication to both chronic anticoagulants and antiplatelet agents 4. contraindication to iodinated contrast agents 5. intracardiac thrombus by transesophageal echocardiography 6. age less than 18 years 7. attempted ipg implant within 3 days 8. life expectancy of \< 12 months 9. chronic hemodialysis 10. myocardial infarction within one month 11. major cardiac surgery within one month 12. female of childbearing potential, pregnant, or breastfeeding 13. noncardiac implanted electrical stimulation therapy devices

Keywords: cardiac resynchronization therapy cardiac pacing electrical stimulation bi-ventricular pacing
the effect of laughter yoga on nurses' burnout level and stress

Conditions: Burnout; Stress

Summary: the purpose of this clinical trial is to determine the effect of laughter yoga on the burnout levels and stress of nurses. the main questions of the study are as follows: 1. what is the burnout level of nurses in the control and intervention groups? 2. what is the stress level of nurses in the control and intervention groups? 3. has there been a change in the burnout levels of nurses practicing laughter yoga? 4. has there been a change in the stress levels of nurses practicing laughter yoga? to compare whether laughter yoga affects burnout and stress levels, participants will be divided into control and experimental groups. the experimental group will undergo laughter yoga sessions twice a week for one month.

the study examines the stress and burnout levels of nurses and their causes. stress in nurses arises from factors such as working conditions, compatibility with colleagues, and insufficient equipment, among others. when this stress becomes chronic, it is referred to as burnout. the maslach burnout inventory will be used to assess burnout levels, while the nurse stress scale will be used to assess stress levels. laughter yoga will be employed as a coping method. laughter serves the function of engaging and relaxing effective muscles, improves respiratory functions, regulates blood circulation, reduces stress hormones, boosts the immune system's defenses, raises pain thresholds and tolerance, and enhances mental function. many studies have observed that the positive effects of laughter yoga on human psychology are beneficial for burnout syndrome. this research will investigate how laughter yoga affects burnout and stress levels.

Eligibility criteria:
inclusion criteria: * being a nurse working day and night shifts * not having participated in laughter yoga sessions before * being willing to participate in the study exclusion criteria: * having a physical condition that prevents participation in laughter yoga sessions (hernia, hemorrhoids, vertigo, respiratory disorders, urinary incontinence, epilepsy) * not being a nurse * working continuously day or continuously night shifts

Keywords: burnout stress nurse laughter yoga
evaluation of the technique lhp (laser hemorrhoidoplasty) in haemorrhoidal prolapse mini invasive surgery

Conditions: Hemorrhoids

Summary: hemorrhoids surgery technics evolved during the past 20 years. recently a new one using laser have been developped. it aims at reducing the blood flow towards hemorroïdal plexuses by photocoagulating with a fiber laser the terminal branches of the superior rectal artery. the aim is to evaluate the efficacy of this technic and note the post surgery pain and events


Eligibility criteria:
inclusion criteria: * age \> 18 * hemorrhoid prolapse grade 2 and 3 * accepting participation exclusion criteria: * hemorrhoid prolapse grade 1 and 4 * other proctological pathology * previous surgery of prolapsus * with anti coagulant treatment * intestinal chronic inflammatory disease * age \< 18 * pregnancy
periprosthetic bone remodeling around uncemented components in total hip arthroplasty

Conditions: Osteoarthritis

Summary: this is a randomized clinical trial comparing two different uncemented femoral stems and two different uncemented sockets using dual-energy x-ray absorptiometry, radiostereometry and clinical evaluation. hypothesis: 1. a short uncemented stem gives less periprosthetic bone resorption in the proximal femur than a conventional uncemented stem. 2. an uncemented acetabular component with a backside of three-dimensional titanium porous construct gives less periprosthetic bone resorption than a backside covered with a conventional porous coating with titanium-beads and a hydroxy-apatite layer.

consecutive patients 40-70 years old who are being planned for total hip arthroplasty (tha) will be eligible for inclusion in the study. periprosthetic bone remodeling, migration of the components and clinical scores will be recorded prospectively.

Eligibility criteria:
inclusion criteria: 1. age 40-70 years old 2. primary osteoarthritis of the hip 3. type a or b femur according to dorr10 4. femoral anatomy allowing implantation of both femoral stems 5. willingness and ability to follow study-protocol - exclusion criteria: 1. inflammatory arthritis 2. abnormal femoral anatomy after hip dysplasia, not suitable for implantation of components 3. treatment with bisphosphonates, cortisol or cytostatic drugs 6 months prior to surgery 4. ongoing oestrogen treatment 5. type c femur according to dorr 6. not suited for the study for other reason (surgeons preference)

Keywords: periprosthetic bone remodeling stress shielding short femoral stem porous titanium construct polyethylene wear
catheter ablation for nonsustained ventricular tachycardia in patients with ischemic cardiomyopathy

Conditions: Ventricular Tachycardia; Ischemic Cardiomyopathy; Reduced LVEF

Summary: despite established implantable cardioverter-defibrillator (icd) therapy and catheter ablation for sustained ventricular tachycardia (vt) in patients with ischemic heart disease (ihd) and reduced left ventricular ejection fraction (lvef), the efficacy of catheter ablation in patients with nonsustained vt has been not yet clarified. the incidence of appropriate icd therapy itself has been reported to be a worse prognostic factor in patients with reduced lvef. therefore theoretically the inhibition of these ventricular incidences can result in the prognostic improvement.to suppress ventricular arrhythmias aside from antiarrhythmic agents, catheter ablation has been developed prominently in this decade along with the technological improvement such as irrigated ablation catheters, three-dimensional mapping systems, multi-polar catheters, and image integration system with ct and mri. the rationale of this trial is to study the efficacy of the eradication of arrhythmogenic substrate in ischemic cardiomyopathy with reduced lvef and nonsustained vt on prevention of the occurrence of sustained vt/vf and icd therapies.


Eligibility criteria:
inclusion criteria: * left ventricular ejection fraction (tte or mri) ≤40% * diagnosed ischemic heart disease * nonsustained monomorphic vt with more than 5 beats in the record of the implantable cardioverter-defibrillator or in any means of electrocardiogram (ecg) including ecg monitor and holter monitoring * icd implantation with primary preventive indication exclusion criteria: * icd implantation within 2 months * previously documented sustained vt/vf (over 30 seconds) or adequate icd shock * no written informed consent

Keywords: ischemic cardiomyopathy prophylactic ablation
the effect of long term therapy with high flow humidification compared to usual care in patients with bronchiectasis (bx)

Conditions: Bronchiectasis Adult; Lung Infection; Quality of Life; Humidifier Lung; COPD Exacerbation; COPD Asthma

Summary: the study is intended to understand the benefit of long term home care therapy with nasal high flow in bronchiectasis patients at home. primary end point is to evaluate daily life compared to usual care and secondary is to evaluate the changes in lung function


Eligibility criteria:
inclusion criteria: * diagnosis of bronchiectasis on hrct * optimization of therapy for at least 15 days before enrollment * autonomous patients with possibilities of practicing rehabilitations cycles exclusion criteria: * osas (odi\>10/h) * home niv * ph\ 55 mmhg * lung cancer * contraindication to high-flow nasal cannula (hfnc)

Keywords: bronchiectasis high flow therapy humidifcation lung infection quality of life
discontinuation of antiviral therapy as a strategy to cure hepatitis b

Conditions: Hepatitis B, Chronic

Summary: cirrhosis or cancer of the liver caused by hepatitis b virus (hbv) are major global health problems. chronic hbv infection has become more common in sweden with immigration. the risk of cancer and the availability of effective antivirals has led to more and more people receiving long-term treatment with antiviral drugs. the disadvantages of this treatment are that it does not have a defined duration and that it very rarely leads to the cure. several published studies suggest that a large proportion of patients who discontinue antiviral therapy after at least three years may achieve lasting cure of the infection or at least do not need to resume treatment. the mechanism of this effect is not known, but it is thought to be due to the fact that the immune response, which is activated when the amount of virus increases after the end of treatment, becomes more effective in eradicating infected liver cells than it was before starting treatment. as a consequence of these findings updated guidelines for treatment of hepatitis b state that for patients that have received nucleoside analogue treatment for \> 3 years, discontinuation is an accepted therapeutic alternative. the purpose of the planned study is to investigate the results of discontinued treatment, in terms of clinical outcome as well as immunological and virological mechanisms. the aim is to include 120 patients at four regional infectious diseases clinics (in gothenburg, borås, skövde and trollhättan), of which 90 will be randomized to discontinue and 30 to continue antiviral treatment. blood samples will be taken regularly to monitor the outcome and for detailed studies of viral antigens and nucleic acid in the blood and for specific analyzes of the cells of the immune system. the goal is to understand why the discontinued treatment in some patients activates an effective immune response and how such an effect can be predicted even before or early after the treatment is stopped.


Eligibility criteria:
inclusion criteria: * nucleoside analogue treatment for hbeag-negative chronic hepatitis b for at least 36 months. exclusion criteria: * liver cirrhosis or liver cancer. * co-infection with hcv, hdv or hiv. * inability to understand study information and give informed consent
real-time fmri neurofeedback for treatment of parkinson's disease

Conditions: Parkinson's Disease

Summary: the aim of the study is to train patients with parkinson's disease to increase activity in a brain area that is involved in the control of motor functions with the use of a technique called real-time fmri neurofeedback (nf) along with regular physical exercise. this will be a randomised and controlled clinical trial to evaluate the benefits of a novel treatment. the investigators expect nf training along with physical exercise practise to better improve motor functions compared to physical exercise alone.


Eligibility criteria:
inclusion criteria: * people with parkinson's disease * hoehn and yahr stages 1-3 of the disease exclusion criteria: * patients with dementia or significant comorbidity * those who fail the safety screening to go into an mri scanner * those who cannot travel to the university
energy supply in athletes and untrained persons with bronchopulmonary diseases

Conditions: Community-acquired Pneumonia; Bronchitis; Chronic Obstructive Pulmonary Disease; Acute Respiratory Infection

Summary: study of the energy supply of bicycle ergometric load in athletes and untrained persons with bronchopulmonary diseases (community-acquired pneumonia, bronchitis, chronic obstructive pulmonary disease and acute respiratory viral infections, to justify the timing of the resumption of training, as well as determination of the volume and intensity of physical activity in training and competitive processes.

1. the aim of the study is to assess energy supply of bicycle ergometric load in athletes and untrained persons who have suffered diseases of the bronchopulmonary system (community-acquired pneumonia, bronchitis, chronic obstructive pulmonary disease and acute respiratory viral infections, to justify the timing of the resumption of training, as well as determining the volume and the intensity of physical activity in the training and competitive processes. 2. in addition to a comprehensive general clinical, radiological (for community-acquired pneumonia) and laboratory examination, all the subjects under study will undergo special studies: spirography and spiroergometry, electrocardiography (ecg), and bicycle ergometry. 3. the main indicators of the functional state of the cardio-respiratory system of the study participants are indicators of the function of external respiration and gas exchange, recorded in the initial state, after load and in the recovery period of 10 and 30 minutes. patients with diseases of the bronchopulmonary system will receive treatment according to generally accepted standards of drug treatment.

Eligibility criteria:
inclusion criteria: 1. the presence of written informed consent of the patient to participate in the study; 2. athletes (men and women) with a diagnosis of community-acquired pneumonia / bronchitis / chronic obstructive pulmonary disease / acute respiratory viral infection on days 28-31 from the onset of the disease, i.e. in the stage of clinical recovery; 3. untrained individuals (men and women) with a diagnosis of community-acquired pneumonia / bronchitis / chronic obstructive pulmonary disease / acute respiratory viral infection; 4. age 17 - 25 years. exclusion criteria: 1. refusal of the patient from further participation in the study; 2. non-compliance with treatment recommendations and regimen.

Keywords: sports medicine bicycle ergometry bronchopulmonary diseases spiroergometry