Kornimate/medical-research-clean huggingface dataset:
monitoring large vessel vasculitis with pet/mr imaging

Conditions: Large Vessel Vasculitis

Summary: large vessel vasculitis (lvv) causes blood vessel inflammation leading to pain, fatigue and complications such as aneurysm formation and stroke. treatments used can have significant side-effects. doctors find it difficult to determine when to start and stop treatment, often leading to over- or under-treatment. a new test is required to determine disease activity that will guide treatment more accurately. this study will recruit participants with active lvv from throughout scotland in order to assess the ability of two new types of scan - positron emission tomography with magnetic resonance imaging (pet/mr) and retinal optical coherence tomography (oct) - to determine disease activity. in addition, i will investigate the link between lvv and heart disease.

large vessel vasculitis (lvv) is a multi-system, autoimmune disease characterised by non-specific symptoms, pain and high glucocorticoid requirements. the lack of a robust biomarker that tracks disease activity makes disease monitoring difficult. this leads to both disease over-treatment, resulting in adverse effects of glucocorticoids, and under-treatment, with the potential for significant vascular complications. additionally, the link between lvv and cardiovascular disease (cvd), which is the main cause of death in these patients, remains poorly characterised. an imaging tool which is capable of accurately monitoring disease activity over time is urgently required. positron emission tomography with magnetic resonance imaging (pet/mr) and retinal optical coherence tomography (oct) have the potential to meet this need. pet/mr is uniquely useful for imaging cvd and utilises \~50% of the radiation dose of pet with computerised tomography. oct is a novel potential biomarker of microvascular dysfunction, systemic inflammation and cvd risk in small vessel vasculitis. participants with a new diagnosis or recent flare of lvv will undergo serial pet/mr and oct scanning alongside established measures of cvd risk. results will be compared with current clinical measures of disease activity and with banked control data.

Eligibility criteria:
inclusion criteria: * a new diagnosis of lvv or a known diagnosis of lvv presenting with disease relapse exclusion criteria: * predominantly cranial symptoms * lvv secondary to other conditions * treatment with high dose glucocorticoids for \>2 weeks at time of recruitment * contraindication to mr or pet * unable to travel to edinburgh * estimated glomerular filtration rate (egfr) \<30 ml/min/1.73m2 * unable to provide informed consent * pregnant or breastfeeding
a global record of patients with anal squamous cell carcinoma with and without hiv infection

Conditions: Anal Squamous Cell Carcinoma; HIV Infections

Summary: due to the scarcity of data on prognostic and predictive influence on cca, epidemiological studies evaluating these factors need to be developed in patients with cca. therefore, the investigators want to evaluate the profile of patients in the real world and from various parts of the world, describing prognostic factors such as cd4 dosage, time of hiv infection, evaluation of viral load, diagnosis of aids, geographic region of diagnosis and treatment, clinical staging, medications concomitant with qrt (risk of drug interactions), comorbidities (possible impact on dose-intensity), use of haart, time of use of haart, radiotherapy modality (conventional 3d vs modulated beam intensity \[imrt\], response to nigro vs ctii regimens, as well as comparing clinical outcomes with patients without hiv infection.


Eligibility criteria:
inclusion criteria: * patients 18 years of age or older * confirmed histological diagnosis of anal canal squamous cell carcinoma. basaloid subtype is accepted * have underundered serological test for hiv infection * any clinical stage exclusion criteria: * lack of data on treatments and clinical outcomes

Keywords: hiv infections anal squamous cell carcinoma
bowel, urinary and sexual function after laparoscopic colorectal surgery

Conditions: Surgery, Laparoscopic; Sexual Dysfunction, Physiological; Colorectal Surgery

Summary: research populations: male patients scheduled for laparoscopic colorectal surgery study method: questionnaire and function tests hypothesis: a laparoscopic nerve-sparing operation is not inferior to reported open surgery in preserving urinary and sexual function.

there have been some reports that laparoscopically assisted rectal resection is associated with a higher rate of male sexual dysfunction compared with the open approach. but these reports are studied retrospectively. we examine the frequency of bowel, urinary and sexual dysfunction prospectively in patients who received laparoscopic colorectal surgery. we examine before operation, 7 days after, 3 months after, 6 months after and 12 months after operation, by questionnaires (international index of erectile function (iief) 、short form-8 (sf8)、international consultation on incontinence questionnaire-short form(iciq-sf)、international prostate symptom score(ipss)、gastro-intestinal functional outcome(gifo)) and function tests (uroflowmetry and us).

Eligibility criteria:
inclusion criteria: * male * laparoscopic right colon resection/laparoscopic rectal surgery * 20-80 years old * ecog performance status (ps) 0-2 exclusion criteria: * emergent operation * previous proctectomy * severe urinary dysfunction

Keywords: laparoscopic colon rectal surgery urinary function sexual function bowel function male
reveal transition - a mechanistic study in transition / stabilized phase of cad

Conditions: Cardiovascular Diseases

Summary: longterm oral anticoagulation with very low dose rivaroxaban (2.5mg bid) in combination with aspirin has been shown superior over standard aspirin monotherapy in patients with stable coronary artery disease (cad) in the compass trial. to date, there are no data comparing these - antithrombotic strategies and to provide insights about mechanistic effects of very low dose rivaroxaban on top of aspirin for longterm treatment. thus, the goal of the planned pilot study will be to identify effects of rivaroxaban on platelet function, platelet-mediated vascular inflammation and particularly, platelet-mediated thrombin generation as well as the underlying mechanisms and to reveal differences in mechanistic effects during longterm treatment with combined novel antiplatelet/anticoagulant strategies. this study is planned as descriptive study.


Eligibility criteria:
inclusion criteria: 1. patients≥ 18 years. 2. troponin-positive acute coronary syndrome (nstemi/stemi) with planned dual antiplatelet therapy (dapt, asa + ticagrelor) for 12 months or stable cad with previous pci and drug eluting-stent (des) + pre-existing pad under treatment with dapt (asa + clopidogrel). 3. patients with coronary artery disease who are younger than 65 years of age are required to have documentation of atherosclerosis involving at least two vascular beds or to have at least two additional risk factors (current smoking, diabetes mellitus, an estimated glomerular filtration rate \[gfr\] \<60 ml per minute, heart failure, or nonlacunar ischemic stroke ≥1 month earlier). 4. informed written consent. exclusion criteria: 1. any condition that requires longterm or already ongoing full oral anticoagulation (e.g. recent systemic embolism, prosthetic heart valves or chronic atrial fibrillation). 2. patients with increased bleeding risk preventing guideline adherent dual antiplatelet therapy
predictive biomarkers for igf1r targeted therapy in ovarian cancer

Conditions: Ovarian Cancer

Summary: the main goal of this study is to employ a novel proteomic approach to identify predictive tumor biomarkers that will increase the efficacy of insulin-like growth factor (igf1r) targeted therapy in epithelial ovarian cancer. it is expected that these predictive biomarkers will be applied to increase the response rate in selected groups of patients.


Eligibility criteria:
inclusion criteria: * patients with ovarian cancer exclusion criteria: * all others
the effectiveness of isometric exercise on the management of chronic shoulder pain

Conditions: Chronic Shoulder Pain

Summary: the aim of this study was to evaluate the influence of the intensity of isometric contraction of shoulder external rotators, comparing the effect of a high-level ic (80% maximal voluntary isometric contraction) versus a low-level isometric contraction (20% maximal voluntary isometric contraction) on pain intensity, pain thresholds, and function in chronic pain shoulder patients.

this was a single-blinded, randomized parallel study. eighty-two patients presenting chronic musculoskeletal shoulder pain were allocated to two groups. patients in group 1 (n= 41) received a five-series isometric contraction of shoulder external rotators at 20% maximal voluntary isometric contraction, while patients in group 2 (n= 41) received similar protocol but the intensity of contraction was set at 80% maximal voluntary isometric contraction. in both cases, each series of ic was done until exhaustion or up to a maximum of 5 minutes. patients received five sessions of treatment during a two-week period. outcome measures included muscle pain sensitivity (pressure pain thresholds) and pain intensity (pain intensity numerical rating score), and shoulder function (constant score).

Eligibility criteria:
inclusion criteria: * male or female having a chronic shoulder soft-tissue injury of at least 3 month duration resulting in a mild to moderate level of disability (constant score scale), pain intensity score between 3 and 8 points (pain intensity numerical rating scale), and age between 18 and 65 years. exclusion criteria: * participants were excluded if they had any contraindications related to the application of isometric exercise, neurological problems (central or peripheral), concomitant physiotherapy or chiropractic treatment, fibromyalgia or general systemic disease conditions, had participated in any moderate or vigorous physical activity in the las 72 hours previous the outcome assessment.
evaluating of role of myeloperoxidase in prediction of outcomes of cardiac surgery procedures.

Conditions: Cardiac Procedure Complication; Ischemic Heart Disease; Valve Heart Disease; Defect Septal

Summary: the main objection is to investigate molecular biology of myocardial damage during cardiac surgery procedures.

to assess outcomes after cardiac surgery procedures. to investigate serum level of myeloperoxidase, morphology of left atrium appendage, to perform genetic analysis and cell biology.

Eligibility criteria:
inclusion criteria: * ischemic heart disease with indications for operation * valve disease with indications for operation * ischemic heart disease combined with valve disease with indications for operation exclusion criteria: * patient refusal

Keywords: ischemic heart disease valve disease septal defect myeloperoxidase molecular biology gene analysis
evaluation of phenotypic and genetic properties in male subjects affected by hypohidrotic ectodermal dysplasia - a

Conditions: Hypohidrotic Ectodermal Dysplasia

Summary: the overall purpose of this study is to learn more about hypohidrotic ectodermal dysplasia (hed) and to help in identifying treatment opportunities. several evaluations will be conducted in this study: 1) the number of skin sweat glands you have and their ability to produce sweat; 2) your ability to grow hair; 3) the structure of your face compared to faces of people affected by hed; 4) molds of your teeth to see if and how they are different than people affected by hed.


Eligibility criteria:
inclusion criteria: 1. males age 14-29 years with clinical diagnosis of hed 2. no scalp shaving in the 6 months prior to enrollment 3. no current medical therapy for hair loss 4. written informed consent for study and genotyping (or signed medical release of previous genetic test results) exclusion criteria: 1. medically significant condition as determined by the pi 2. known hypersensitivity to pilocarpine or pilocarpine-like muscarinic agonists (e.g. urecholine, salagen, pilocar, provocholine) 3. presence of cardiac pacemaker

Keywords: x-linked hypohidrotic ectodermal dysplasia hypohidrotic ectodermal dysplasia xlhed hed
comparison of two insertion technique of i-gel

Conditions: Prostate Cancer; Prostate Tumor; Bladder Cancer; Bladder Tumor

Summary: to evaluate the efficacy of rotational technique in the insertion of i-gel

the i-gel is one of the 2nd generation supraglottic airways. the rotational technique is known to increase the success rate of insertion of other supraglottic airways. the investigators try to evaluate the efficacy of rotational technique in the insertion of i-gel.

Eligibility criteria:
inclusion criteria: - patients scheduled for general anesthesia(transurethral resection of bladder tumor or transurethral resection of the prostate) using i-geltm exclusion criteria: * history of recent postoperative sore throat * history of difficult airway * mouth opening \< 2.5 cm * emergency operation

Keywords: success
effects of aerobic exercise during the early rehabilitation after ischemic stroke

Conditions: Ischemic Stroke; Stroke Rehabilitation

Summary: the goal of this clinical trial is to study the effects of aerobic exercise during the early rehabilitation after ischemic stroke. the main questions it aims to answer are: * how is the recovery of motor function affected by regularly walking during the first 90 days after an ischemic stroke? * does regularly walking during the first 90 days after ischemic stroke affect cognition, physical comfort and the immune system? participants will exert a heart rate controlled walking programme of walking 3-5 times 30-45 minutes per week. researchers will compare the recovery of the walking group to a control group without any demands regarding physical exercise.

from animal experiments we know that wheel running has a positive impact on functional recovery after experimental stroke. we aim to translate this observations from our animal experiments into the clinic. therefore, patients will be included shortly after ischemic stroke and start an aerobic exercise programme during the first 14 days after the event. at baseline visit the participants receive a neuropsychological testing with the focus on cognition, fatigue and depressive symptoms. furthermore, we perform blood sampling for analysis of the activation state of the peripheral immune system. the patients receive a lactate ergometry with measurement of the 3 mmol lactate threshold to define the optimal heart rate range for their walking exercise. we perform the fugl-meyer assessment for the upper and the lower extremity. for correlation with training-induced structural changes participants receive cerebral magnetic resonance imaging to assess the density of axonal fibre tracts (assessed by mri-dti). during the following 90 days participants in the intervention group are instructed to walk 3-5 times for 30-45 minutes per week and control the exercise intensity by optical heart rate measurement via smartwatch. the daily step count will be protocolled by the intervention and the control group. participants will measure their resting heart rate in the morning before getting up to prevent overexercising. the assessments of the baseline visit will be repeated after 90 days.

Eligibility criteria:
inclusion criteria: * initial nihss or nihss determined at the moment of maximum deterioration 1-18 * age \> 18 * ischemic stroke * pre-stroke independence * sufficient motivation / patient's desire to cooperate / exercise for 3-5x/week for 30-45 min exclusion criteria: * transient ischemic attack * premorbid motor disability / musculoskeletal injury / severe arthritis impairing degree of movement * balance and transfer function that requires assistance * cardiac disease not allowing to perform aerobic training * inability to give informed consent

Keywords: motor function aerobic exercise immune system cognition
characterization of white blood cells sub-populations from multiple sclerosis patients.

Conditions: Multiple Sclerosis

Summary: multiple sclerosis (ms) is a chronic progressive neurological autoimmune disease, that gradually affects patient's quality of life. there are about 2.5 millions patients world wide, with an increasing cost burdon. up to date, it remains unclear who are the exact cells to initiate the disease. during the disease, the repertoire of cells expands and undergoes changes. the purpose of this study is to characterize those changes.


Eligibility criteria:
inclusion criteria: * patients with diagnosis of ms according to the revised criteria of mcdonald or healthy volunteers * ability to provide written informed consent. exclusion criteria: - active malignant disease
using it to improve access, communication and asthma in african american and hispanic/latino adults

Conditions: Asthma; Communication

Summary: background: asthma morbidity is high in inner-city minority adults, despite the existence of efficacious therapy. tailored, patient-centered interventions are needed to improve access to care and patient-provider communication. access and communication increasingly rely on information technology (it) as new incentives arise to use the electronic health record (ehr). the ehr patient portal (pp) gives patients web-based communication with providers and practices. how the poor and those with limited educational opportunities can take advantage of these is unclear. in contrast, the investigators have found that home visits (hvs) by community health workers (chws) can improve access to care for children and promote caretaker-clinician communication. the investigators also found many inner-city adults have internet access and are willing to learn to use the pp. objective: to examine the benefits for adults of using the pp with and without hvs by chws who will encourage/facilitate pp use, understand patients' social context, and enhance communication with the medical team. the investigator hypothesize all patients will benefit from pps, and that the addition of hvs will be particularly helpful for those with low literacy or language barriers. specific aims test if the 1-year interventions result in 1) better within-group asthma outcomes, 2) better outcomes in one group over the other, 3) more communication (use of pp) and access (appointments made and kept) which mediate the interventions' effects on asthma outcomes, and 4) effect modification by literacy level, primary language, and convenience of internet access. methods: in a randomized controlled trial, 301 adults, predominantly african american and hispanic/latino, with uncontrolled asthma recruited from low income urban neighborhoods will be assured internet access and taught to use the pp, with and without hvs from a chw. chws will 1) train patients to competency in pp use, 2) enhance care coordination, 3) transmit a view of the complex social circumstances of patients' lives to providers, and 4) make up for differences in patients' health literacy skills. patient outcomes are asthma control, asthma-related quality of life, emergency department (ed) visits, and hospitalizations for asthma or any cause. together asthma and other health conditions affect patients' ability to perform their daily tasks and care for their families. potential benefits of the intervention are enhanced patient-clinician communication, access to care, improved health, and ability to use it.


Eligibility criteria:
inclusion criteria: * adults predominantly african american and hispanic/latino with uncontrolled asthma recruited from low income urban neighborhoods exclusion criteria: * severe psychiatric or cognitive problems that would make it impossible to understand and complete the protocol.

Keywords: asthma, asthma control, asthma-related quality of life electronic health record, portal, health literacy
nervous system manipulation and botanicals for the treatment of recurrent ear infections in children

Conditions: Otitis Media

Summary: the purpose of this study is to determine the efficacy of echinacea therapy and osteopathic manipulation for the prevention of further ear infections in children with recurrent ear infections (otitis media).

acute otitis media (inflammation of the middle ear) occurs in 60% of infants during the first year of life and in 85% by age 3. approximately 17% of children suffer recurrent otitis media during the first year of life. following acute otitis media, middle ear fluid effusions can persist for weeks to months. approximately 40% of children with middle ear effusions have mild to moderate hearing loss for the duration of the effusion, and several studies have found evidence for impaired speech and language development among children with prolonged middle ear effusion. since antibiotic use has become widespread, concern has emerged regarding antibiotic resistant s. pneumoniae strains and other bacteria. children with recurrent otitis media commonly receive prophylactic antibiotic therapy or surgical insertion of tubes to prevent accumulation of middle ear effusion. the prevalence of pediatric use of complementary alternative medical (cam) approaches for prevention of otitis media has not been widely quantified. this study will evaluate the use of osteopathic manipulation and echinacea therapy to prevent ear infection in children with recurrent otitis media.

Eligibility criteria:
inclusion criteria: * written informed consent
hemodynamic effects during land vs water exercise for older adults with orthostatic hypotension

Conditions: Orthostatic Hypotension

Summary: the purpose of the study is to understand how blood pressure, heart rate, and symptoms of low blood pressure (such as dizziness or nausea) are affected by positional changes and exercise when on land or in the water for people who tend to experience orthostatic hypotension.


Eligibility criteria:
inclusion criteria: * self-report of dizziness upon standing (from sit or supine position) or known diagnosis of orthostatic hypotension * able to stand independently for 3-5 consecutive minutes * able to walk independently (with or without an assistive devise) * medically stable for last month * score of 3 or greater on mini-cog (standardized outcome measure to detect dementia) * full coronavirus vaccination exclusion criteria: * diagnosis of dementia * contraindication for pool exercise (such as infected open wounds, fecal incontinence, diarrhea.)
endostar combine with radiotherapy in brain metastasis of nsclc

Conditions: Non-small Cell Lung Cancer

Summary: observe the effect os radiotherapy plus or not plus endostar in the treatment of brain metastasis in nsclc

the investigators will observe the time controlled by the brain lesion after the test and the total survival time of the patients. meanwhile, during each follow-up, the investigators will extract cerebrospinal fluid for genomic analysis of cerebrospinal fluid

Eligibility criteria:
inclusion criteria: * nsclc brain metastasis exclusion criteria: * kps\<60