Kornimate/medical-research-clean huggingface dataset:
quadripolar crt-d on currently approved lead systems

Conditions: Heart Failure

Summary: the purpose of the study is to evaluate different ways to program around extracardiac stimulation.


Eligibility criteria:
inclusion criteria: * subject is medically indicated for implantation with a boston scientific (bsc) dynagen or inogen x4 crt-d (or any future fda approved bsc x4 crt-d) and already implanted with/scheduled to receive a commercially available quadripolar left ventricular lead * subject is willing and capable of providing informed consent and participating in all testing and study visits associated with this investigation at an approved center and at the intervals defined by this protocol * subject is age 18 or above, or of legal age to give informed consent specific to state and national law exclusion criteria: * subject has a known or suspected sensitivity to dexamethasone acetate (dxa) * subject is enrolled in any other concurrent study, without prior approval from bsc * women of childbearing potential who are or might be pregnant at the time of study enrollment

Keywords: heart failure cardiac resynchronization therapy (crt) crt-d quadripolar pacing
pms assessing the long-term efficacy and safety of nevirapine therapy (combined with other arv drugs) in hiv-1 positive patients in daily clinical practice.

Conditions: HIV Infections

Summary: the aim of this trial is to evaluate the safety and virological and immunological efficacy of viramune® on a background of different antiretroviral drug combinations.


Eligibility criteria:
inclusion criteria: the inclusion criteria follow the same criteria which are describe in the newest spc. exclusion criteria: the exclusion criteria follow the same criteria which are describe in the newest spc.
the effect high velocity low amplitude hip mobilization on strength in subjects with lower extremity pathology

Conditions: Hip Joint; Muscle Weakness

Summary: introduction: lower extremity weakness associated with musculoskeletal pathology can cause activity limitations. physical therapy intervention in the form of exercise is commonly directed at improving muscular performance, however, neuromuscular adaptations may limit the effectiveness of traditional strengthening exercises. manual therapy techniques have been used as a disinhibitory intervention to increase muscle activation and strength before participating in strengthening exercises or performing functional tasks while there is recent evidence to support joint mobilization as a valuable manual therapy disinhibitory intervention currently, there is no evidence to substantiate anecdotal experience that a hvlat hip distraction mobilization improves muscle performance in subjects with lower extremity pathology and lower extremity weakness. the purpose of this study was to determine if a hvlat hip distraction mobilization would result in an immediate change of maximal force output of the quadriceps, gluteus maximus and gluteus medius. methods: forty individuals with a lower extremity pathology volunteered for this study. inclusion criteria were having a unilateral musculoskeletal pathology, being greater than 18 years of age, 10% decrease in muscle strength in symptomatic side compared to healthy side, and absence of medical precautions that would prevent a maximal effort strength test and exclusion criteria included individuals with a history lower extremity recent muscle or tendon ruptures (within the past 6 months) and postoperative knee, hip and ankle surgery. demographic data, including diagnosis from referring physician were collected. all subjects completed the lower extremity function scale (lefs). a single evaluator blinded to the involved extremity was responsible for quadriceps, gluteus medius and maximus strength analysis pre and post mobilization of both symptomatic and non-symptomatic sides. the subject underwent the hvlat hip distraction mobilization of the symptomatic side, and an immediate re-assessment of strength of both symptomatic and non-symptomatic sides followed the mobilization.


Eligibility criteria:
inclusion criteria: * individuals with a lower extremity pathology volunteered for this study * being greater than 18 years of age * 10% decrease in muscle strength in symptomatic side compared to healthy side * absence of medical precautions that would prevent a maximal effort strength test. exclusion criteria: * included individuals with a history lower extremity arthroplasty. * recent muscle or tendon ruptures (within the past 6 months) * unhealed fractures * neurological diseases * malignant cancer * osteoporosis * active infections processes * early postoperative knee, hip and ankle surgery with range of motion and weight bearing restrictions.
assessing the effects of educational training aimed to improve pain-reporting reliability in children after surgery

Conditions: Surgery

Summary: treating pain, just as treating other medical conditions, depends on accurate assessment of patient's condition. when assessing pain, as other subjective symptoms, the challenge is twofold because the assessment is dependent on patient's understanding and use of the scale, all the more so in children so far, attempts to improve pain assessments have been focused on the development and refining pain scales. no emphasis has been placed on improving patient's ability to report their pain. our purpose is to evaluate a training program designed to improve the quality of children's post-surgical pain intensity reports. after receiving helsinki approval, eligible children and their parents will signed informed-consent. after surgery, the children, their parents, and the department nurses will assess children's pain intensity. immediately after the nurse assessment, parents will assess their child's pain (blindly and independently) and the children will report their pain on four different pain scales. children aged 8-17, hospitalized in rambam medical-center for elective surgery will be invited to participate. children in the experimental group will be exposed to a training program, developed for this study, aimed to teach and train how to report pain. the control group will receive the standard pre-surgical instructions.


Eligibility criteria:
inclusion criteria: 1. children at age 8-17 years; 2. absence of psychiatry, cognitive, and/or neurological disorders; 3. understand the purpose and the instructions of the study, agree to participate and parent signed inform consent. exclusion criteria: 1. children suffering from post traumatic stress disorder.
brimonidine vs altp in progressing human glaucoma

Conditions: Glaucoma

Summary: this study is evaluating possible non-intraocular pressure (iop) related effects of the alpha-1 agonist brimonidine in human subjects affected by a progressive glaucomatous optic neuropathy. brimonidine was proven as neuroprotective in several pre-clinical animal studies.

patients with open angle glaucoma and a history of relative stability of the visual field are followed for 18 months. a visual field is measured every 3 months for a total number of n = 6 eligible fields at the end of this phase. then, those eyes showing progression of the field (i.e. deterioration of th eexisting glaucoma), are randomized to receive either 0.2% brimonidine tartrate eyedrops b.i.d. or 360° argon laser trabeculoplasty in one session. either treatment will be put "on top" of the pre-existing anti-glaucoma therapy. then, a further 18-month phase is planned, with a sequnece of field taken at the same pace as the previous phase. progression is detected (and measured) acording to a trend-analysis (i.e. regression vs time of single points and of clusters of adjacent points).

Eligibility criteria:
inclusion criteria: * glaucomatous visual field defect on achromatic perimetry (24/2 humphrey full threshold,abnormal ght and cpsd, p\<0.01) considered clinically "unstable" * iop \< 20 mmhg on repeated readings with no more than 2 medications, * open angle on gonioscopy, * glaucomatous optic neuropathy (hrtii, moorfields regression analysis), * clear lens (locs2 score \< c1, n0, p0) * best corrected visual acuity better than 0.2 logmar (etdrs chart), * no previous bulbar surgery * manifest refraction within - 5 and + 2 diopters * no comorbidity (amd and diabetic retinopathy.and negative history for neurological diseases) exclusion criteria: * closed angle * previous bulbar surgery * unstable iop * unreliable visual fields on historic data

Keywords: neuroprotection alpha one agonists glaucoma visual field
study of pk/pd, safety and tolerability of lik066 in patients with decreased renal function.

Conditions: Renal Impairment

Summary: the purpose of this trial was to evaluate whether the study drug, lik066, causes glucose excretion in urine in patients with varying degrees of decreased kidney function and in subjects with normal kidney function. blood samples were collected to measure the concentrations of lik066 and to study the pharmacokinetics of lik066. pharmacokinetics is meant to study how lik066 is absorbed, distributed and eliminated, in other words what the body does to the drug. the results of this study may be used to help determine whether lik066 can be used to treat people with reduced kidney function and the proper dosing regimen.


Eligibility criteria:
inclusion criteria: * written informed consent must be obtained before any assessment is performed. * male and female subjects age 18-78 years, inclusive, with controlled health condition as determined by past medical history, physical examination, electrocardiogram and laboratory test at screening. * patients with type 2 diabetes, hba1c \<10% at screening. * body mass index (bmi) ≤ 50 kg/m\^2 at screening. exclusion criteria: * patients with type 1 diabetes * evidence of clinically significant liver function test: alt, ast, gamma-gt, alkaline phosphatase \>3 x uln; serum bilirubin \> 1.5 x uln. * patients undergoing any method of dialysis * clinically significant gi disorder related to malabsorption or that may affect drug or glucose absorption. * subjects who experienced ketoacidosis, lactic acidosis or hyperosmolar coma within 6 months of screening visit.

Keywords: renal function sodium-glucose co-transporter pharmacokinetics decreased renal function decreased kidney function kidney disease urinary glucose excretion uge
the effect of the duty loading on the stress response of physician

Conditions: Physiological Stress; Psychological Stress

Summary: the investigators will study in the possibility of cardiovascular disease, caused by the duty loading, of physician of internal medicine. the investigators will also explore if there {dose response effect} between the duty loading and the stress response of physicians of internal medicine. therefore, the investigators will compare the stress responses of physicians of internal medicine during with different duty loading ( non-duty day, one duty area with 3 wards, 2 duty areas with 6 wards) in a observational method. those stress response will be measured by cardiovascular risk indicators, including blood pressure, heart rate variability, blood sampling and urine sampling.


Eligibility criteria:
inclusion criteria: * attending physicians of internal medicine of taipei municipal hospital, certified by taiwan society of internal medicine. exclusion criteria: * thyroid dysfunction * pregnancy, diabetes mellitus * history of cardiovascular disease (stroke, coronary arterial disease, or myocardial infraction) * current smokers, or * taking sleeping pills or b-blocker

Keywords: physician duty loading stress response physician with different amount of duty area
tongue dysbiosis effects on arterial pressure of periodontitis patients

Conditions: Periodontitis; Normal Blood Pressure

Summary: blood pressure control is crucial for individuals' wellbeing. however, many daily aspects such as diet could impair blood pressure control. in addition, many people living under different conditions in different countries are affected by some kind of gum disease. these people experience gingival bleeding, bad breath, teeth mobility and pain. throughout gum disease development the number of oral germs in the mouth increases including their levels in tongue surface. oral bacterial are able to convert nitrate widely found in food in nitrite which influences blood pressure. frequently treatment of gum diseases general combines manual instrumentation with mouthwashes. however, it has been suggested that reduction of oral bacteria by mouthwashes, especially chlorhexidine, is accompanied by decreased conversion of nitrate to nitrite and that this minor nitrite availability would increase blood pressure. therefore, this is a point to be clarified for patients, physicians and dentists. this study will investigate the relation between treatment with mouthwashes and blood pressure of patients with destructive gum disease based on nitrite levels in saliva, bacterial levels in tongue and values of arterial blood pressure which will be monitored over 6 months. in addition, usual clinical parameters and alteration of oral cells' dna will be also monitored overtime. patients will be treated under local anesthesia and manual instrumentation within 24 hours. they will receive oral care products too. there will be 3 treatment groups (manual instrumentation + chlorhexidine mouthwash \[2 times a day for 3 weeks\], manual instrumentation + placebo mouthwash \[2 times a day for 3 weeks\] and manual instrumentation + no mouthwash) and 2 dental appointments before treatment. after treatment, patients will be examined at 7, 14, 21, 90 and 180 days. saliva, plaque and cell sampling will be fast and by no invasive methods.


Eligibility criteria:
inclusion criteria: * 12 natural teeth; chronic periodontitis stages ii and iii; no systemic medication; non smokers; normal blood pressure; no mouthwash regular use; antibiotics \> 3 months prior to study; dental treatment \> 3 months prior to study. exclusion criteria: - known alergy to chlorhexidine; removable prosthodontics apparatus; pregnant and breast feeding women.
comparative effect of chewing sticks and toothbrushing on plaque removal and gingival health

Conditions: Plaque Induced Gingivitis

Summary: the purpose of the proposed study is to compare the effect of chewing sticks (miswak) and the toothbrushes on plaque removal and gingival health.

dental plaque removal is essential in maintaining oral health. methods for oral hygiene vary from country to country and from culture to culture. the use of a wood stick (miswak or chewing stick) for brushing the teeth is considered an important tool for oral hygiene care in many afro-asian communities. the aim of the study is to compare the effect of the chewing stick (miswak), and toothbrushing on plaque removal and gingival health. the participants comprise 18 healthy saudi arabian male volunteers aged 21 to 30 years, at taibah university in saudi arabia. the study was designed as a single, blind, randomized split-mouth study. professional tooth cleaning was conducted, and after six weeks use of either the miswak or toothbrush on each quadrant, modified plaque and gingival indices, were recorded.

Eligibility criteria:
inclusion criteria: * healthy individuals * presence of at least 14 teeth exclusion criteria: * subjects on medications (antiinflammatory or antibiotics)

Keywords: gingivitis dental plaque oral hygiene toothbrush chewing sticks
canine-assisted profiling of lung cancer from human breath

Conditions: Lung Cancer

Summary: the study aims to optimize and define a reproducible and non-invasive method for canine assisted lung cancer detection, using human breath samples from patients and controls for training and testing purposes.


Eligibility criteria:
inclusion criteria: healthy volunteers, lung cancer or other lung disease. exclusion criteria: other known malignancy.
vascular function in adolescent, diabetic children

Conditions: Type 1 Diabetes

Summary: the objectives of this investigator initiated study are to: 1. determine if and when vascular abnormalities occur during early adolescence 2. determine if poor diabetic control is related to vascular abnormalities. the development of vascular plaques and vascular contractility will be assessed through the use of the syphmgnocor equipment.

up to 85 type 1 diabetic and healthy controls, 12-14 years of age, will be recruited for the study. once the permission/assent form has been completed, a cuff will be applied to the arm and the pressure tonometer will be used on various vessels. cardiovascular data will be recorded. the procedure is non-invasive, will last approximately 10 minutes and will be performed during a routine clinic visit. onset of diabetes and level of diabetic control as measured by the most recent hbg a1c (relative to the study visit) will be obtained from the medical record. microalbumin levels covering the prior 12 months will be collected from the medical record of diabetic subjects.

Eligibility criteria:
inclusion criteria: * boys and girls ages 12-14 years who have type 1 diabetes or are healthy controls exclusion criteria: * children and adolescents who do not meet inclusion criteria

Keywords: vascular abnormalities type 1 diabetes healthy control subjects
non-technical skills of emergency physicians in a virtual emergency department

Conditions: Emergencies

Summary: the investigators will study nontechnical skills of emergency physicians in a virtual standardized emergency room and their impact on quality of care.

the ability to manage multiple patients and anticipate the risk of error related to task interruptions or disruptions has been identified among relevant non-technical skills (nts) for practicing emergency medicine. however, the link between these skills and the quality of care has not been quantified. nts are usually analyzed by qualitative methods such as interviews, direct observations, or questionnaires that have low performance according to the grade system (grading of recommendations, assessment, development and evaluation). the investigators have created and validated an experimental model of a virtual, authentic and realistic emergency department (ed). the platform has been modelled in a "second life" environment. the nts of emergency physicians will be assessed and recorded during simulated care of multiple virtual patients. the nts association with ed length of stay and disposition decision will be analyzed. this study will be an internal pilot study and will include 30 emergency physicians who practice emergency medicine for at least two years. sessions will be performed in the toulouse institute of health care simulation, toulouse university hospital. they will be composed of three stages: briefing (30 minutes), simulated practice (3 hours), and debriefing with an explicit interview (30 minutes). two researchers and a computer technician will supervise the sessions. the data will be obtained by analyzing the video recorded during the simulated practice and the interview.

Eligibility criteria:
inclusion criteria: * active emergency physicians working in an ed of the french midi-pyrenees region * two years of practice in emergency medicine or more * volunteer to participate in the study exclusion criteria: * emergency physician working in another setting than ed, outside the midi-pyrenees region, or practicing emergency medicine for less than 2 years.

Keywords: serious game simulation virtual emergency department nontechnical skills
randomised study of high-flux haemodialysis and haemodiafiltration

Conditions: End Stage Renal Disease

Summary: the most common forms of renal replacement therapy currently in use are high flux haemodialysis (hf-hd) and haemodiafiltration (hdf). although these techniques appear similar to the patient, there are important differences in what happens to the blood as it travels through the dialysis machine. during hdf, the machine controls hydrostatic pressure across the dialyser to remove additional water together with toxins from the blood and this fluid volume is continually replaced with an ultra-pure solution. hdf has a theoretical advantage removing more waste substances, especially larger molecules, from the blood than hf-hd which may be of benefit to the patient in the medium to long term.despite the theoretical advantages, trials have so far been unable to find any significant difference in death rates or the development of health problems among patients on hdf or hf-hd. it is therefore important to examine other factors which may help doctors and patients to decide which treatment to use. the investigators have designed a study which aims to answer three main questions: 1. does hdf make patients feel better? 2. is blood pressure more stable on hdf in comparison with hf-hd? 3. are phosphate levels and other blood parameters better controlled with hdf than hf-hd? the investigators will do this by randomly assigning patients on hf-hd to receive 2 months of either hf-hd or hdf with as equivalent treatment prescriptions as possible and without the patient knowing which treatment they are receiving. after two months the patients will switch to the alternative form of dialysis for a further two months. during the study the investigators will ask the patients how long it took them to recover from the preceding session of dialysis, assess the frequency of symptomatic low blood pressure and also perform blood tests at set intervals to measure specific blood parameters.


Eligibility criteria:
inclusion criteria: * receiving hf-hd for at least 3 months * reliable vascular access (i.e. use of the same fistula, graft or tunnelled central venous catheter for at least 1 month) * aged 18 or older exclusion criteria: * currently receiving hdf * emergency hospital admissions within the preceding 4 weeks * life expectancy less than 6 months * neoplasia * unable to give informed consent * unable to perform qol questionnaire or self report recovery post-dialysis time
study of escitalopram in adult patients with major depressive disorder

Conditions: Major Depressive Disorder

Summary: escitalopram is the s-enantiomer of citalopram. both escitalopram and citalopram are selective serotonin reuptake inhibitors (ssris) and are used to treat depression in adults. this study is designed to evaluate the efficacy, safety, and pharmacoeconomics of escitalopram and an active comparator in patients with major depressive disorder.


Eligibility criteria:
inclusion criteria: * patients must meet diagnostic and statistical manual, fourth edition (dsm-iv) diagnostic criteria for major depressive disorder. * the patient's current depressive episode must be at least 12 weeks in duration. exclusion criteria: * women who are pregnant, women who will be breastfeeding during the study, and women of childbearing potential who are not practicing a reliable method of birth control. * patients who currently meet dsm-iv criteria for: a. bipolar disorder; b. schizophrenia or any psychotic disorder; c. obsessive-compulsive disorder; d. mental retardation or any pervasive developmental disorder or cognitive disorder. * patients who are considered a suicide risk. * patients with a history of seizure disorder, or any history of seizure, stroke, significant head injury, or any other condition that predisposes toward risk of seizure.

Keywords: depression major depressive disorder escitalopram