Kornimate/medical-research-clean huggingface dataset:
evaluation of a home-based aomi intervention on cognitive function and depression among adults with sci

Conditions: Spinal Cord Injuries (SCI); Depression; Motor Imagery; Cognitive Functions

Summary: the investigators propose a pilot randomized clinical trial to determine if adults with spinal cord injury (sci) show improved cognitive function and depression following home-based action observation and motor imagery (aomi) training. it is hypothesized that the home-based aomi intervention will show satisfactory feasibility and acceptability. they also hypothesize that aomi training can be used as a rehabilitative tool for improving cognitive function and depression in adults with sci, because it engages and strengthens similar neural systems as actual exercise.

this study is an assessor-blinded, two-arm pilot randomized controlled trial with repeated measures (pre-, post-intervention, and 1-month follow-up). this study aims to evaluate the preliminary effects of a home-based aomi intervention on sci adults' cognitive function and depression. forty-six sci adults will be randomized into the intervention group, receiving an 8-week aomi intervention combined with basic wheelchair exercises, or the control group, receiving basic wheelchair exercises with the same duration, number of sessions, and frequency as the intervention group. one-on-one qualitative interviews will be implemented post-intervention to evaluate participants' feelings about the effectiveness of their cognitive function and emotional status, their views about opinions of the study's acceptability, strengths, limits, and recommendations for further improvement of the program. the primary outcomes of intervention effectiveness include cognitive function and depression; secondary outcomes include multi-model magnetic resonance imaging (mri) acquisition, chronic pain, motor imagery ability, and self-efficacy for exercise.

Eligibility criteria:
inclusion criteria: * diagnosis of sci according to the international standards for the neurological classification of sci with confirmation by computed tomography/magnetic resonance imaging; * at least 18 years old; * with stable spinal systems and good vital signs, and currently living in the community and having sci for more than 6 months; * no contraindications to undergoing mri examination (e.g., no metal or electronic devices in the body, not pregnant, and absence of claustrophobia); * having a mobile internet terminal (usually a smartphone) and proficient independent or caregiver-assisted usage; * able to communicate in cantonese and to provide informed consent. exclusion criteria: * having severe problems in hearing, verbal communication, or vision; * engaged in ongoing psychotherapy or any other physiotherapy/ exercise/ relaxation interventions; * physically active for more than 150 minutes moderate-intensity exercise per week; * diagnosis of mental disorders or substance misuse; * with severe cognitive impairment (hong kong montreal cognitive assessment (hk-moca) score ≤ 18.
longitudinal study of biomarkers

Conditions: Central Nervous System Tumor

Summary: biomarkers are small molecules that can be detected in the body fluids of patients; they often correlate with the presence of a cancer. micrornas and proteins are small molecules which have recently been discovered in cells. they are known to be responsible for the normal development of cells and when they are disrupted can contribute to the development of cancer. many previous studies have been done evaluating the expression of micrornas and proteins in normal tissues as well as a wide variety of cancers. recently, micrornas and proteins from tumor cells have been detected circulating in the blood of patients with cancer. this presents a novel opportunity to use micrornas and proteins in the blood as an early predictor of cancer as well as a marker of response to therapy. previous work in our labs have identified mirnas and proteins in the blood and cerebrospinal fluid (csf) of pediatric patients with brain tumors. to determine a longitudinal evaluation of the presence of micrornas and proteins in the blood, cerebrospinal fluid and urine of patients with central nervous system tumors from diagnosis through the course of their treatment. though the duration of active treatment varies significantly based upon the diagnosis, patients will be followed for up to 24 months after enrollment onto the study).


Eligibility criteria:
inclusion criteria: * patients ages 1 day to 21 years * patients with radiographically and/or histologically confirmed cns tumors treated at children's memorial hospital and lurie children's hospital in chicago * patients must be newly diagnosed and have had no prior anticancer therapy (except surgery) for their current diagnosis. the use of steroids is permissible. * patients and/or parents/legal guardians must have signed an informed consent and assent when applicable. exclusion criteria: * patients who have completed treatment and do not require routine blood draws and/or lumbar punctures * patients who are considered too ill to participate as determined by their treating physician * patients who are pregnant or lactating
asthma and quantifying delivery of radio labeled aerosol

Conditions: Asthma

Summary: introduction: inhalation therapy has been established as an efficient route to treat asthma exacerbations, but coupled to noninvasive ventilation (niv) remains quite challenging. objectives: the aim of this study were to compare radiaoaerosol pulmonary index and radioaerosol mass balance in the different compartments (pulmonary and extrapulmonary) using vibrating mesh nebulizers (vmn) and jet nebulizer (jn) coupled to noninvasive ventilation (niv). material and methods: the investigators assessed 10 stable moderate to severe asthmatics in a crossover study. patients was randomly assigned to participate in both phases of the study: phase 1(niv+mn) and phase 2(niv+jn). dtpa-tc99m with radioactivity of 25 mic was used to inhaler using jn positioned in the circuit using a "t" piece, particle size generation in a five micron range and oxygen flow tritated at eight l/min and mn was positioned in the mask, particle size generation in a one range and connected to electrical energy. niv was used a bilevel pressure through a face mask attached with straps and pressure adjusted were 12 cmh2o and 5 cmh2o as inspiratory and expiratory pressures, respectively. after, radioactivity counts were performed using a gama camera and regions of interest were delimited. to calculate aerosol mass balance the investigators considered the amount of radioaerosol deposited into the lungs, upper airways, stomach, nebulizer, circuit, inspiratory and expiratory filters, and mask divided for each of these compartments and represented as a percentage.


Eligibility criteria:
inclusion criteria: * stable moderate to severe asthma (fev1 \> 60% and \> 80% and pef with a variation of 30% from the predicted values to moderate and fve1 \> 60% and ); * more than one year elapsed since the diagnosis of asthma; * none exacerbation in the last six months; * age between 18 - 60 years, from both sexes, * able to understand verbal commands * consent to participate in this protocol. exclusion criteria: * presence of dyspnea; * smoking history; * cardiopulmonary diseases (chronic obstructive pulmonary disease, pneumonia, cardiac failure, myocardial infarction, pneumothorax); * hyperthermia; * hemodynamic instability (heart rate \> 150 bpm and systolic blood pressure \< 90 mmhg); * arrhythmia absence; * pregnancy * contraindications for use of noninvasive ventilation

Keywords: vibrating mesh nebulizers noninvasive ventilation residual volume pulmonary scintigraphy radioaerosol nebulization.
effect of astaxanthin supplementation on plasma malondialdehyde levels and nihss of stroke patients

Conditions: Cerebral Stroke; Malondialdehyde; Oxidative Stress

Summary: this is an interventional randomized, controlled trial in analyzing the effects of astaxanthin supplementation on plasma malondialdehyde levels and nihss of acute ischemic stroke patients. according to published studies, it was hypothesized that acute ischemic stroke patients who were given astaxanthin would have lower plasma malondialdehyde levels and lower nihss score compared to the control group.

there were a total of 24 subjects, with 12 subjects in the intervention group and 12 subjects in the control group.the participants were divided into an interventional group and a control group. the interventional group was given astaxanthin supplementation 2 x 8mg per day for 7 days, while the control group was given placebo.

Eligibility criteria:
inclusion criteria: * 40-65 years old * has acute ischemic stroke with an onset of less than 48 hours before hospital admission * nihss score of less than or equal to 15 * can consume food orally or enterally * has given their consent to be a participant in the study exclusion criteria: * renal failure * liver failure * is taking supplements other than his or her main stroke medications * has taken antioxidant supplements in the last 3 months before stroke onset

Keywords: astaxanthin antioxidant plasma malondialdehyde nihss score ischemic stroke
an exploration of the neuroplasticity of endogenous analgesia in health and chronic pain

Conditions: Fibromyalgia

Summary: transcranial magnetic stimulation (tms) is a neurophysiological tool for studying cortical functions, and in addition, has an analgesic therapeutic effect whose underlying mechanism is unknown. the proposed research will use tms in conjunction with brain imaging and electrophysiology to examine cortical plasticity and connectivity modifications induced by repetitive tms (rtms) targeted to affect cortical regions associated with endogenous analgesia (ea). this will be carried out in both healthy and chronic pain (fibromyalgia) states. rtms analgesic intervention, targeted to the motor cortex (m1) will be preceded and followed by structural and functional magnetic resonance imaging (fmri), and diffusion tensor imaging (dti). this will be done in order to examine alterations of cortical and brainstem mechanisms involved in ea and to investigate connectivity changes between cortical and sub-cortical regions of the ea networks. the latter as well as ea efficiency and pain-related personality variables will be used to assess individual differences in neuroplasticity within the ea systems in both healthy subjects and chronic pain patients.

transcranial magnetic stimulation (tms) is a neurophysiological tool for studying cortical functions, and in addition, has an analgesic therapeutic effect whose underlying mechanism is unknown. the proposed research will use tms in conjunction with brain imaging and electrophysiology to examine cortical plasticity and connectivity modifications induced by repetitive tms (rtms) targeted to affect cortical regions associated with endogenous analgesia (ea). this will be carried out in both healthy and chronic pain (fibromyalgia) states. rtms analgesic intervention, targeted to the motor cortex (m1) will be preceded and followed by structural and functional magnetic resonance imaging (fmri), and diffusion tensor imaging (dti). this will be done in order to examine alterations of cortical and brainstem mechanisms involved in ea and to investigate connectivity changes between cortical and sub-cortical regions of the ea networks. the latter as well as ea efficiency and pain-related personality variables will be used to assess individual differences in neuroplasticity within the ea systems in both healthy subjects and chronic pain patients .

Eligibility criteria:
inclusion criteria: * a prior fms diagnosis by a rheumatologist or pain specialist based on american college of rheumatology (acr) preliminary diagnostic criteria for fibromyalgia * healthy subjects - no pain/psychiatry/neurological diseases exclusion criteria: * other chronic pain, psychiatric or neurological diseases. all will be asked to withdraw from any pain-relieving medications for 24h before the testing.
result of tdcs in asd children with comorbidities like pandas, rare genetic diseases or autoimmune disorders

Conditions: Attention; Visual Perceptual Weakness; Social Behavior; Fluency Disorder; EEG With Periodic Abnormalities

Summary: results of the application of 100 sessions of tdcs for 12 months in children between 6 and 11 years old with autism spectrum disorder with rare diseases, genetic problems or pandas

tdcs will be applied to 90 children diagnosed with asd with mu activity in one of their two temporal lobes and to another 90 children tdcs will not be applied but rather conventional treatments such as the denver method, etc., in addition to collecting their electroencephalograms in eyes open condition, evoked potentials will be performed. with mismatch negativity paradigm to calculate the p300 wave every 25 sessions with a rest of 5-6 weeks between every 25 sessions and the changes in voltage and frequency of the eeg will be analysed using fft \& psd, as well as the latencies and amplitudes of its p300 wave.

Eligibility criteria:
inclusion criteria: * age between 7 and 15 years old * diagnosis: pdd, asd or pandas * have genetic alterations with geneticist reports like: mutation, random mating between organisms, random fertilization or crossing over (or recombination) between chromatids of homologous chromosomes during meiosis. * natural birth without caesarean or complications * normal pregnancy exclusion criteria: * head trauma * brain injuries like meningitis or encephalitis, including sars, herpes or mers infections * epilepsy * rare diseases with auto-immune disease * rare diseases with endocrinology problems * fever or biochemical problems in the first blood test (first visit) * vaccines reactions
high flow vs conventional oxygen in head and neck surgery

Conditions: Pulmonary Disease; COPD

Summary: patients undergoing major head and neck surgery are at risk for postoperative pulmonary complications. the goal of this randomized clinical trial is to evaluate the effectiveness of high flow heated humidified oxygen at preventing postoperative pulmonary complications after major head and neck surgery, when compared to conventional oxygen therapy (aerosol cool mist).

participants enrolled in this study are randomly assigned to receive either conventional oxygen therapy (aerosol cool mist) or heated humidified high flow oxygen via the trach after head and neck surgery. the study team then collects information regarding clinical outcomes to explore if there are differences between the two groups.

Eligibility criteria:
inclusion criteria: * patients undergoing major head and neck surgery that includes any neck dissection * major head and neck surgery is defined as having a mean length of stay of three or more days, based on the diagnosis \[14\] * surgery requires an elective tracheostomy for airway protection or laryngectomy tube in the case of total laryngectomy exclusion criteria: * \<18 years of age

Keywords: head neck surgery heated humidification cool humidification
impact of post-traumatic stress disorder treatment by reconsolidation therapy on fibromyalgia syndrome

Conditions: Fibromyalgia Syndrome; Posttraumatic Stress Disorder

Summary: the aim of the study is to demonstrate a significant improvement in quality of life specific to patients with fibromyalgia syndrome in patients with fibromyalgia syndrome with comorbid posttraumatic stress disorder, treated with reconsolidation blockade. patients receive a treatment with propranolol associated with reconsolidation blockade of traumatic story once a week during 6 weeks, with evaluation at inclusion and at 3 months.


Eligibility criteria:
inclusion criteria: * adult over 18 years old * diagnosis of fibromyalgia syndrome according to acr 2016 criteria * pcl-5 \> 44 suggesting the presence of a comorbid post-traumatic stress disorder * meet the dsm-5 criteria for post-traumatic stress disorder secondary to exposure to a traumatic event according to dsm-5 criteria, both unique or repeated and regardless of the date or location of the traumatic event. * pain relief treatment and/or psychotropic treatment stabilized for a period greater than or equal to two months. * signature of a consent form * patient able to understand and read french exclusion criteria: * psychotic disorders * unstable bipolar disorder * patients with a systolic blood pressure \< 100 mmhg or heart rate \< 55 as established during the initial visit * significant anormal ecg * medical contraindication to taking propranolol * adverse reactions or previous intolerances to a beta blocker * current intake of another beta blocker which can not be stopped during the protocol, regardeless the galenic. * current intake of a drug with potential contraindication with the propranolol, according to the summary of product characteristics of the propranolol. * patient under legal protection, under guardianship or under curatorship * patient having suffered a head trauma for less than a year or with clinical symptoms and neurological sequelae * known severe suicide risk (mini-s and medical exam) * current opioid addiction or alcohol dependence * patients treated for less than 2 months with antidepressants or painkillers * patients unafiliated to a social health care * woman who is pregnant or breast-feeding or whithout efficient contraception
improving insomnia in patients with opioid use disorder

Conditions: Opioid Use Disorder; Insomnia

Summary: this randomized, 35-day research study (n=20) explores the effects of a simplified mindfulness intervention in opioid use disorder patients stabilized on buprenorphine maintenance therapy (bmt), aiming to alleviate insomnia, monitor bmt dose, and decrease non-prescribed opioid use. patients tap along with their breathing at bedtime and practice sleep hygiene; controls do sleep hygiene only. adherence will be monitored by a smartphone application.

this research study is exploring the effects of a simplified mindfulness intervention in patients with opioid use disorder who are stabilized on buprenorphine maintenance therapy. this study aims to improve their sleep quality, monitor changes in buprenorphine dose, and decrease the frequency of non-prescribed opioids use. we will be enrolling a total of 20 patients who are above 18 years of age and have insomnia symptoms, opioid use disorder, and access to a smartphone. patients will be asked to utilize a smartphone application which will allow us to monitor adherence; they will be asked to tap on the screen in time with their breathing before bedtime. buprenorphine maintenance therapy is used to treat opioid use disorder (the buprenorphine will be prescribed by their healthcare provider as part of their standard clinical care and is not a research study intervention) by minimizing withdrawal symptoms, but symptoms of insomnia often persist. symptoms of insomnia include difficulty falling/staying asleep, anxiety regarding sleep, or daytime sleepiness.

Eligibility criteria:
inclusion criteria: 1. age greater than 18 2. diagnosed with opioid use disorder 3. stable on buprenorphine maintenance therapy for at least 4 weeks 4. at least 3 nights of greater than 30 minutes of sleep onset latency 5. speak english above 6th grade level 6. access to smart device exclusion criteria: 1. inability to communicate verbally 2. involved in another insomnia study 3. medical or other factors that in the opinion of the study research team would interfere with their ability to participate in the intervention

Keywords: mindfulness
interleukin-2 in treating patients with stage iii or stage iv kidney cancer

Conditions: Kidney Cancer

Summary: the purpose of this study is to assess the efficacy of post-operative high-dose bolus interleukin-2 (il-2) in patients with high-risk renal cell carcinoma (rcc).

the primary objective of this prospective, randomized, controlled trial is to compare the disease-free and overall survival of patients with stage iii or iv high-risk renal cell carcinoma (rcc) who were treated with adjuvant high-dose interleukin-2 vs observation alone. patients are stratified according to their disease classification and randomized to one course of il-2 \[600,000 u/kg every 8 hours on days 1 to 5 and days 15 to 19 (maximum 28 doses)\] or observation.

Eligibility criteria:
inclusion criteria * an eastern cooperative oncology group (ecog) performance status of 0 or 1. * adequate organ function as defined by a white blood cell (wbc) count of 4,000/l; a platelet count of 100,000/l; a hemoglobin level of 10 g/dl; a serum creatinine of 1.5 mg/dl or creatinine clearance of 60 ml/min; and a direct bilirubin level of 1.5 mg/dl. * forced expiratory volume at 1 second more than 2.0 l or 75% of predicted for height and age from pre-enrollment pulmonary function testing. * no history or evidence of cardiac disease on ecg * no prior systemic treatment for rcc, but patients may have received prior locoregional radiation therapy to solitary resectable metastases, which must have undergone surgical resection before enrollment. * no prior history of invasive malignancy in the past 5 years * human immunodeficiency virus (hiv) negative * female patients must not be pregnant or planning to become pregnant exclusion criteria • age younger than 16

Keywords: renal cell cancer renal cell carcinoma interleukin-2
two preventive measures on caries progression in mixed dentition patients.

Conditions: Dentist's Role

Summary: primary objective: assessing the clinical effect of sdf and laser on the prevention of initial caries progression with and without pits and fissure sealants in both permanent and primary molars. secondary objective: effect of sdf and laser application on the subsequently applied pits and fissure sealants.

primary objective: assessing the clinical effect of sdf and laser on the prevention of initial caries progression with and without pits and fissure sealants in both permanent and primary molars. scoring caried out by icdas scoring criteria over a 1 year follow up period secondary objective: effect of sdf and laser application on the subsequently applied pits and fissure sealants. measured by simonson's criteria over 1 year follow up period.

Eligibility criteria:
inclusion criteria .children aged 6-9 years old. .patients categorized as moderate to high caries risk (deft index \>1) showing more than 1 new carious lesions or restorations in the last 36 months according to "ada caries risk assessment form (age \>6)" .a split mouth study design was followed where all four second molars were selected for intervention in the primary molar group, while all first molars were selected for intervention in the permanent molar group. .the four molars selected in each patient (primary / permanent) should be fully erupted with no gingival overhangs /operculum and with no history of previous restorations or prior sealants. .according to international caries detection and assessment system icdas grading, molars with (0, 1, 2) scores only were included. exclusion criteria: .uncooperative or mentally challenged patients, with bad oral hygiene or rampant caries. .patients providing history of bruxism or clenching affecting the posterior occlusion were excluded. .children with known allergies or sensitivities to resins or silver products. .molars that showed well-coalesced, self-cleansing pits \& fissures or shallow grooves and severe forms of hypoplasia / fluorosis were excluded. .patients \& parents with high esthetic demands and concerns. .unmotivated patients, or parents who refused to sign the consent form.

Keywords: sdf diode laser pits and fissure sealants primary molars permanent molars