Kornimate/medical-research-clean huggingface dataset:
mygenerank: a digital platform for next-generation genetic studies

Conditions: Heart Diseases

Summary: many conditions affecting health are caused by a combination of environment, behaviors, and genes. while individuals can alter some factors in their lives to reduce the chances of developing different diseases (e.g., not smoking cigarettes), the contribution from genetic risk encoded by dna remains with people throughout their lives. scientists are still trying to determine the entirety of genetic factors that influence disease, but for some conditions it has been shown that the factors identified thus far can begin to identify people at high to low genetic risk. looking across the genome, scientists can calculate a cumulative genetic risk score - which can be used to rank genetic risk compared to other worldwide populations. the goal of this study is to determine how genetic risk influences health decisions and other things that can be controlled in life. the first genetic risk score is calculated for coronary heart disease (cad). cad ultimately leads to heart attacks, heart failure and sometimes sudden cardiac death and is the main reason heart disease remains as the number one cause of death worldwide. other researchers have shown that this genetic risk score can be used to identify people with low, intermediate, and high risk for coronary heart disease. it has also been shown that the use of statins (cholesterol lowering drugs) provides greater benefit and protection against heart attack for people with high genetic risk for coronary artery disease. leveraging the apple researchkit and the researchkit linked 23andme api, customers of 23andme are able to provide researchers access to their genomic data. participants will use the researchkit app to provide consent, view study information, answer surveys, and contact the study team. participants will be asked to complete 3 surveys. one before viewing genetic risk scores, one immediately after viewing scores, and one 6 months after viewing scores.


Eligibility criteria:
inclusion criteria: * customer of 23andme willing to share their 23andme data * user of apple mobile device exclusion criteria: * under 18 years old
ep combined with rfa for ampullary neoplasms with intraductal biliary extension

Conditions: Ampullary Adenomas

Summary: endoscopic papillectomy is the preferred approach for management of ampullary adenomas. endobiliary radiofrequency ablation (rfa) is an ablative therapy that has been used to treat malignant biliary strictures. the aim of this study was to evaluate the safety and efficacy of endoscopic papillectomy combined with endobiliary rfa for ampullary neoplasms with intraductal biliary extension.

ampullary neoplasms remain rare, with a reported prevalence of 0.04% to 0.12% in autopsy studies. , endoscopic papillectomy is now recognized as a safe and reliable alternative to surgery for ampullary adenomas and is associated with high success rates (72%-95%), low morbidity (10%-30%), and minimal mortality (0.2%-1%). typically, however, intrabiliary extension of the adenoma has been regarded as a contraindication for endoscopic papillectomy. surgical referral is therefore recommended with intraductal extension, particularly when the length of extension exceeds 1 cm. radiofrequency ablation offers a potentially safe and effective treatment for malignant biliary strictures. the use of rfa as a primary treatment for intraductal dysplasia after endoscopic papillectomy has been shown in few small case series to be feasible with the primary limitation of short follow-up periods. the primary aim of this study was to describe our experience with rfa in patients with ampullary neoplasia and associated intraductal extension who were not surgical candidates.

Eligibility criteria:
inclusion criteria: * patients with histologically proven ampullary adenoma or adenocarcinoma with intraductal biliary extension ≥1cm who were deemed medically unfit for surgery or declined surgery exclusion criteria: * pancreatic invasion, lymph node invasion, distant metastasis, or coagulopathy.

Keywords: endoscopic papillectomy radiofrequency ablation ampullary neoplasms intraductal biliary extension
mammographic density and the risk of tumor recurrence in asian women: a case-control study

Conditions: Case Control Study

Summary: to evaluate the influence of mammographic breast density at diagnosis on the risk of cancer recurrence and survival outcome in patients with invasive breast cancer after surgery


Eligibility criteria:
inclusion criteria: * women diagnosed with invasive breast cancer between 2004 and 2009 who had undergone surgery and had the mammographic breast density ascertained before, or at, diagnosis. exclusion criteria: * women diagnosed with invasive breast cancer between 2004 and 2009 who had not undergone surgery or who had no mammographic breast density ascertained before, or at, diagnosis.
resilience training for work-related stress in employees and the influence of the lecture format on training success

Conditions: Work-Related Stress; Burnout

Summary: a study to analyze the psychophysiological effects of a preventative, 4-week resilience training with mobile heart rate variability biofeedback (hrv-bfb) in a workplace setting and the influence of the lecture format (digital vs. live) on the training success.

this was a three-arm, non-randomized, controlled trial to examine the effects of a preventative, 4-week resilience training with mobile hrv-bfb on work-related stress in white-collar employees. participants were asked to exercise autonomously three times per day for five minutes with the mobile hrv-bfb device. they additionally attended three lectures at the beginning of the first, third, and forth week. the aim of the lectures was to mediate a theoretical knowledge and to prepare the participants for the autonomous training. to examine the potential influence of the lecture format, one group attended live lectures (blended learning condition) and one group received access to online lectures (e-learning condition). results of study's outcome measures were compared with a waitlist control group. outcome measures were assessed at baseline (t0), after the 4-week intervention (t1), and at 4-week follow-up (t2).

Eligibility criteria:
inclusion criteria: * written informed consent * employees of the company at which the study is conducted exclusion criteria: * implanted pacemaker * medically diagnosed heart failure or arrhythmia * medically prescribed cardiac drugs (e.g., beta-blockers, diuretics, ace inhibitors, calcium channel blockers, or antiarrhythmic agents)
planned semi-elective lung tx study

Conditions: Lung Transplantation

Summary: in the current practice of lung transplantation, transplants are performed on a 24/7 schedule with a significant amount of procedures occurring overnight in order to minimize organ ischemic time. however, transplantation during the day time may lead to several advantages related to patient safety, including the presence of rested staff performing optimally, larger number of in-house professionals for emergency situations, and professional well-being. advances and refinements in preservation practices have evolved to show that extended periods of preservation can be achieved without compromising outcome. based on this, it is hypothesized that the avoidance of nighttime lung transplantation through prolonged pulmonary preservation will lead to at least similar patient outcomes compared to the current practice of 24/7 transplantation. during the period of this study, overnight transplants will be moved to a later start time (earliest 6am). if lungs meet criteria for direct transplantation, they will be preserved with cold static preservation at 10°c within a special refrigerator. the maximum preservation time from donor cold flush to recipient anesthesia start time will be 12 hours.


Eligibility criteria:
recipient inclusion criteria * primary lung transplantation * informed consent provided * 18-80 years old recipient exclusion criteria * re-transplantation * multi-organ transplantation * \>80 years old donor inclusion criteria * age ≤70 years old * donor lungs are suitable to go straight to lung transplantation donor exclusion criteria * age \>70 years old * concerns with organ preservation technique * donor lungs require assessment by ex vivo lung perfusion (evlp)
clinical-randomized study of the influence of rehabilitation therapy using strength and blood flow restriction training on muscular fitness and regeneration after elective total knee arthroplasty

Conditions: Osteoarthritis (OA) of the Knee; Muscle Atrophy

Summary: the present study investigates the effects of blood flow restriction training on muscular recovery during out-patient rehabilitation after elective total knee arthroplasty

the present study evaluated the impact of blood flow restriction training in the context of three-week outpatient rehabilitation following tka, in accordance with the guidelines of the german pension insurance system. the in-rehabilitation and post-rehabilitation muscle status, strength, knee functionality, impairments in daily life and subjective pain perception were measured.

Eligibility criteria:
inclusion criteria: * physical fitness for rehabilitation * primary tka surgery * bmi \< 35 exclusion criteria: * sickle cell anemia * vascular intervention on the lower extremities * open wounds
pregnancy and fertility registry

Conditions: Breast Neoplasms; Pregnancy; Fertility Preservation

Summary: the pregnancy and fertility (prefer) study is a comprehensive program aiming to optimize care and improve knowledge around the topics of fertility preservation and pregnancy issues in young breast cancer patients. the program was initiated at the national institute for cancer research, irccs aou san martino - ist in genova (liguria region, italy) and then it has been spread to other italian institutions under the umbrella of the gruppo italiano mammella (gim) study group. it is composed of two distinctive studies, one assessing fertility (i.e. prefer-fertility) and the other pregnancy (prefer-pregnancy) issues. hence, two different study protocols were developed under the umbrella of the prefer registry. prefer-fertility aims to obtain and centralize data about the preferences and choices of young cancer patients on the fertility preservation strategies available in italy. furthermore, it aims to assess the outcomes of patients undergoing one or more strategies for fertility preservation in terms of success of the techniques (i.e. recovery of ovarian function, number of cryopreserved oocytes, post-treatment pregnancies) and safety (i.e. long-term survival outcomes). prefer-pregnancy has two main objectives: 1) to obtain and centralize data on the management of breast cancer diagnosed during pregnancy, the obstetrical and paediatric care of children born after prior in utero exposure to anticancer treatments, and the long-term survival outcomes of these patients; 2) to obtain and centralize data on the clinical outcomes of breast cancer survivors that achieve a pregnancy after prior diagnosis and treatment of breast cancer.


Eligibility criteria:
inclusion criteria: * breast cancer diagnosis * age between18 and 45 years (only for prefer-fertility) * have not received any radiation or chemotherapy for cancer before enrolment (only for prefer-fertility) * absence of metastatic disease (only for prefer-fertility) * diagnosis of breast cancer during pregnancy or within 1 year from the end of pregnancy or pregnancy after prior diagnosis and treatment for breast cancer (only for prefer-pregnancy) * informed consent exclusion criteria: * inability to provide written informed consent * stage iv disease at diagnosis (only for prefer-fertility) * serious psychiatric disorders

Keywords: breast neoplasms fertility preservation pregnancy
mobile phone technology for prevention of mother-to-child transmission of hiv: acceptability, effectiveness, and cost

Conditions: HIV; HIV Infections; AIDS; Antiretroviral Therapy

Summary: although gains have been made in achieving the health-related millennium development goals (mdg), much is still needed in countries affected by high levels of hiv/aids. prevention of mother-to-child transmission (pmtct) is a cornerstone strategy in reducing infant mortality from hiv. the study will employ a cluster randomized control trial (crct) with 26 health facilities randomized to two arms (intervention or control) to determine the effect of mobile phone technology on completion of key pmtct milestones from antenatal to six weeks postpartum. the study will examine the acceptability, effectiveness, and cost of implementing a pmtct-focused mhealth strategy among hiv-infected pregnant women, health workers, and male partners.


Eligibility criteria:
inclusion criteria (female): * hiv-positive pregnant women seeking anc at a study site * up to 32 weeks gestation * own or have access to a mobile phone on which they can receive calls and sms messages exclusion criteria (female): * hiv-positive pregnant women who have already initiated antiretroviral treatment inclusion criteria (male): * referral by pregnant female partner

Keywords: hiv aids pmtct mobile phone sms
omega-3 fatty acids for major depressive disorder during pregnancy

Conditions: Depressive Disorder

Summary: whether high-dose omega-3 fatty acids supplement would be an effective treatment in patients with major depressive disorder during pregnancy and breast-feeding.


Eligibility criteria:
inclusion criteria: * eligible participants were pregnant women, aged 18 to 40 years, with major depressive disorder onset between their 16th week (second trimester) and 32nd week (third trimester) of gestation at the department of obstetrics. exclusion criteria: * subjects were excluded with a dsm-iv diagnosis of bipolar disorders, psychotic disorders, substance abuse or dependence for at least 3 months, or any axis-ii diagnosis of borderline or antisocial personality disorder.

Keywords: omega-3 fatty acids major depressive disorder pregnancy women during pregnancy and after childbirth are more vulnerable to psychiatric disorders pharmacotherapy for depression during pregnancy is a clinical dilemma. omega-3 polyunsaturated fatty acids (pufas) might be a promising alternative of treatment for pregnant women with depression.
the short term safety and efficacy of inhaled l-arginine in patients with cystic fibrosis

Conditions: Cystic Fibrosis

Summary: the objective of this trial is to determine the safety and effect on pulmonary function of 14 days of inhaled l-arginine versus placebo administered over a period of 14 days in a cohort of cf patients.

despite the inflammatory nature of lung disease in cf, nitric oxide (no) formation as well as the expression of nos2 has been found to be decreased in cf airways. while the reasons for impaired airway no formation remain incompletely understood, there is evidence that low no formation contributes to lung pathophysiology in cf. constitutive endogenous formation of nitric oxide (no) in airways is thought to play a role in neurotransmission, smooth muscle relaxation and bronchodilation. previous animal experiments have shown that the addition of l-arginine, the precursor of enzymatic no formation, resulted in a significantly greater relaxation of tracheas. there is also evidence that a single dose of inhaled l-arginine improves pulmonary function in cf. in this study we will assess the effect of l-arginine inhalation on lung function, nitric oxide formation, airway inflammation and bacterial infection in cf patients.

Eligibility criteria:
inclusion criteria: * diagnosis of cf as defined by two or more clinical features of cf and a documented sweat chloride concentration \> 60 meq/l and/or two well characterized disease causing cftr gene mutations * 14 years of age and older at enrollment * clinically stable at enrollment * ability to comply with medication use, study visits and study procedures * fev1 % predicted \> 40% \< 80 % as calculated by reference equations exclusion criteria: * respiratory culture positive for: b. cepacia complex within past year or at screening * use of systemic corticosteroids within 30 days of screening * use of intravenous antibiotics or oral quinolones within 14 days of screening * history of biliary cirrhosis, portal hypertension, or splenomegaly * other major organ dysfunction * history of lung transplantation or currently on lung transplant list * supplemental oxygen therapy * oxygen saturation \< 95 % on room air * positive pregnancy test at screening * investigational drug use within 30 days of screening * history of alcohol, illicit drug or medication abuse within 1 year of screening * acute respiratory symptoms * inability to take any form of bronchodilator * wheezing at the time of study

Keywords: cystic fibrosis l-arginine pediatrics pulmonary function
fibrosis, inflammation and brain health in atrial fibrillation.

Conditions: Atrial Fibrillation; Stroke

Summary: protocol synopsis sponsor: oslo university hospital title: fibrosis, inflammation and cerebral infarction in patients with atrial fibrillation study design: the study is an observational prospective study of atrial fibrillation patients undergoing direct-current cardioversion. primary objective: to assess the prevalence and causes of new silent cerebral ischemic lesions after programmed direct-current cardioversion using diffusion-weighted sequences in brain mri (dwmri). secondary objectives: to study the impact of inflammation measured by biomarkers and cardiac 18f-fdg-pet on the risk for new silent cerebral ischemic lesions after direct-current cardioversion for af. to assess the impact of fibrosis measured by biomarkers on the risk for new silent cerebral ischemic lesions after direct-current cardioversion for af. to assess cognitive and cerebral structural and metabolic changes after direct-current cardioversion for af using cognitive assessments and cerebral and cardiac 18f-fdg-pet before and 12 months after treatment. number of subjects: 50 study centers: østfold hospital trust duration of study participation: * enrollment: 18 months * follow-up period: 12 months * total study duration: 30 months primary endpoints: • number of new small cerebral infarcts detected with dwmri two weeks after direct current cardioversion. secondary endpoints: * rate of af recurrence within 1 year after direct current cardioversion * change in levels of inflammation biomarkersfrom baseline to 12 months follow-up * change in levels of fibrosis biomarkers from baseline to 12 months follow-up * cognitive function at 12 months follow-up * changes in uptake pattern on cerebral 18f-fdg-pet from baseline to 12 months follow-up * changes in uptake pattern on cardiac 18f-fdg-pet from baseline to 12 months follow-up * brain volume at 12 months follow-up * white matter volume 12 months follow-up * grey matter volume 12 months follow-up * cortical volume 12 months follow-up * rsi-derived diffusion parameters 12 months follow-up: fast apparent diffusion coefficient, extracellular water fraction, fractional anisotropy; free water fraction; intracranial volume; nawm: normal appearing white matter; neurite density; rsi: restriction spectrum imaging; sadc: slow apparent diffusion coefficient;restricted fractional anisotropy; white matter lesions.


Eligibility criteria:
1. known atrial fibrillation 2. age \<80 years 3. cha2ds2-vasc ≤ 4 4. planned direct-current cardioversion exclusion criteria: 1. cha2ds2-vasc \>4 2. life expectancy less than 1 year 3. patient otherwise not eligible for the study or adherent for follow-up (eg nonresident) or has concurrent disease affecting outcome (e.g. multiple sclerosis, cancer)
dbs of ppn to improve walking in chronic sci patients

Conditions: Spinal Cord Injuries; Spinal Injuries; Spinal Fractures

Summary: spinal cord injury (sci) is a devastating condition affecting over 1 million individuals in north america. sci often results in severe motor impairments with few available treatments options. recent groundbreaking research has demonstrated that deep brain stimulation (dbs) of the mesencephalic locomotor region (mlr) greatly improves locomotion in a rat model with incomplete sci. the pedunculopontine nucleus (ppn - a specific nucleus within the mlr) in humans has already been established as an auxillary dbs target in parkinson disease (pd), to improve motor control and locomotion. dbs of other targets has also been safely used in humans with sci for chronic pain. these findings suggest that dbs of the ppn may have potential as a therapeutic intervention in the sci population to improve locomotion. our goal is to conduct a pioneering study in 5 select motor-incomplete chronic sci patients that cannot functionally ambulate to examine if bilateral dbs of the ppn improves walking

this prospective repeated measures study of the implantation of bilateral ppn electrodes in a small series of chronic sci patients will aim to examine safety, feasibility, and potential efficacy. this research will investigate the effects of electrode implantation, electrical stimulation and intensive locomotion training over a 1-year period. motor assessments will be performed at regular intervals with stimulation on and off in a double-blind fashion (subjects and researchers will be unaware of stimulation setting), to determine if subjects have improved ambulation with stimulation on compared with off, and if their ambulation improves over the course of the study observation period with stimulation on.

Eligibility criteria:
inclusion criteria: * age 18 to 65 (at time of enrolment) * sci that occurred greater than 2 years ago * current neurological status of ais grade c or d, can stand with aids but not functionally ambulate * residence in gta exclusion criteria: * other substantial medical conditions causing physical restrictions, neurological deficits, or causing excessive risk of surgery * professional or other time commitments affecting availability for numerous hospital visits * contraindications to mri (eg. metal in eye) * women that are pregnant (according to a bhcg serum/urine test at time of screening), or are actively seeking to become pregnant