Kornimate/medical-research-clean huggingface dataset:
comparison of a-prf vs bone wax in hemostasis, pain relief and healing following exodontia

Conditions: Post-Extraction Socket Hemostasis; Post-Extraction Socket Pain Relief; Post-Extraction Socket Healing

Summary: the goal of this clinical trial is to compare the pain relief and healing effect of a-prf and bone-wax in patients having mandibular tooth-extractions. the main question\[s\] it aims to answer are: in the perspective of improvement in pain and healing; * does a-prf performs better than control group? * does bone-wax performs better than control group? * healing index and pain scale score comparison of a-prf and bone-wax; if one is better than the other? participants will be asked to give resoponse to a post-operative symptom severiety (posse) scale. an investigator will score the patient's extraction for hemostasis and on healing index \[describe the main tasks participants will be asked to do, treatments they'll be given and use bullets if it is more than 2 items\]. if there is a comparison group: researchers will compare \[insert groups\] to see if \[insert effects\].


Eligibility criteria:
inclusion criteria: * all patients who need extraction of mandibular posterior teeth * overall, systemically healthy individuals (established based on history, i.e., patients who do not take medicine for any systemic condition). * inr within normal range. exclusion criteria: * patients with a diagnosed systemic condition. * patients who are immunocompromised. * patients who are unwilling to participate or withdraw from the study. * patients who fail to report on the seventh and twenty-first post-extraction day. * patients with physical or mental impairments who need assistance in taking their medications.

Keywords: platelet rich fibrin wound healing tooth extraction pain severity bone wax
peep setting in covid19-related ards

Conditions: ARDS Due to Severe Acute Respiratory Syndrome Coronavirus 2

Summary: the best way to titrate positive end-expiratory pressure (peep) in patients suffering from acute respiratory distress syndrome is still matter of debate. electrical impedance tomography (eit) in a non-invasive technique that could guide peep setting based on an optimized ventilation homogeneity.

covid-19 related ards patients admitted to the icu in march 2021 requiring mechanical ventilation were enrolled. patients were monitored by an esophageal catheter and a 32-electrode eit device. within 48 hours after the start of mechanical ventilation, different levels of peep were applied based upon peep/ fraction of inspired oxygen tables, positive end-expiratory transpulmonary (pl)/ fio2 table, and eit. respiratory mechanics variables were recorded.

Eligibility criteria:
inclusion criteria: * covid19-related ards under invasive mechanical ventilation exclusion criteria: * none
development of a community-based network for drug abusers

Conditions: Adolescent

Summary: hidden drug abuse remains a significant concern for public health. an appropriate intervention is necessary to encourage hidden drug abusers to report their situations and seek professional help. this project aims to develop a community-based network to identify and refer hidden drug abusers in hong kong, and assess its effectiveness.

this study will be completed within 18 months, and be divided into 3 phases, including (1) a video competition for anti-drug abuse, (2) development of a community-based network through training 150 peers aged 13-18 as anti-drug ambassadors (adas) to deliver anti-drug messages based on the award model, and (3) a mass promotional campaign organized by adas in the community. a one-group pre-test and repeated post-test design will be adopted to evaluate the overall effectiveness of the community-based network. we will assess the knowledge, attitudes and practices regarding anti-drug abuse of the adas. data collection will be conducted at baseline, post-training, 3 months and 6 months after the training workshop.

Eligibility criteria:
inclusion criteria: * aged 13 - 18 years * able to speak cantonese and read chinese exclusion criteria: * identified cognitive, behavioral or learning problem(s) * identified mental illness(es)

Keywords: hidden drug abuse community-based network ambassadors brief intervention adolescents
comparison of two insulin detemir formulations in healthy volunteers

Conditions: Diabetes; Healthy

Summary: this trial is conducted in europe. the aim of this trial is to compare two formulations of insulin detemir containing an isotonic agent in healthy volunteers.


Eligibility criteria:
inclusion criteria: * considered generally healthy upon completion of medical history and physical examination as judged by the investigator * body mass index (bmi) between 18 and 27 kg/m\^2, inclusive * non-smoker * fasting plasma glucose maximum 6 mmol/l exclusion criteria: * known or suspected allergy to trial products or related products * previous participation in this trial * pregnant, breast-feeding or the intention of becoming pregnant or not using adequate contraceptive measures (intrauterine device (iud) that has been in place for at least 3 months, sterilisation, the oral contraceptive pill (which should have been taken without difficulty for at least 3 months) or an approved hormonal implant) * the receipt of any investigational drug within the last 3 months prior to this trial
short-term mortality prediction by the sofa score in acute decompensated heart failure

Conditions: Acute Decompensated Heart Failure

Summary: data on the use of sequential organ failure assessment (sofa) in patients with cardiovascular disease are increasing. several studies demonstrated that the sofa score can identify short-term mortality in patients with acute decompensated heart failure (adhf). this study was conducted to determine the prognostic value of the admission sofa score in patients hospitalised for adhf and to assess its ability in predicting the 30-day readmission rate.


Eligibility criteria:
inclusion criteria: * all patients over 18 years old who were hospitalised for acute heart failure were included (either new-onset acute heart failure or adhf). exclusion criteria: * patients with septic shock or pulmonary infarction were excluded.

Keywords: sofa score acute decompensated heart failure
study of the impact on the evolution of the disease in the medium term of the implementation of a system of extended follow-up by telephone interview of patients with an eating disorder organized by the nurses of the eating disorder referral center

Conditions: Eating Disorders; Recurrence; Relapse

Summary: the referral center for eating disorders provides for a systematic many years follow-up of patients under care with an annual assessment at the center. the investigators have recently shown the frequency of relapse in the first 7 years after diagnosis, but the literature remains poor on this epidemiology and on the risk factors for relapse. the investigators would therefore like to extend this follow-up for an additional 3 years after remission with an annual telephone nursing interview for all cured patients.


Eligibility criteria:
inclusion criteria: * patients diagnosed with an eating disorder confirmed at the multidisciplinary consultation meeting of the referring center and considered cured (in remission). for patients with oral disorders, inclusion is within one year of recovery * patient affiliated or entitled to a social security plan * oral participation agreement * pregnant women exclusion criteria: * persons deprived of liberty * patients under guardianship or curatorship * refusal to participate
periodontal treatment and glycemic control

Conditions: Diabetes Mellitus Type 2

Summary: the purpose of this study is to determine the effects of non surgical periodontal treatment on glycemic control in type ii diabetics.

the selected patients in treatment group will be given mechanical periodontal treatment in the form of scaling and root planning while the non intervention group patients will not receive treatment until the end of the trial.

Eligibility criteria:
inclusion criteria: * diagnosed patients of type 2 diabetes mellitus for at least 2 years * hba1c values \>6.5 % as per ada criteria * non smokers * patients with at least 16 standing teeth * at least 8 teeth with one site having mild to moderate periodontal disease exclusion criteria: * smokers * type 2 diabetics with complications e.g. renal, ophthalmic etc * patients with chronic infections * patients who get hospitalized or have to change their medications during the course of study
mitroflow dl post approval study- north america

Conditions: Aortic Stenosis; Aortic Regurgitation; Aortic Valve Insufficiency; Heart Valve Diseases; Cardiovascular Abnormalities; Cardiovascular Diseases; Congenital Abnormalities; Heart Diseases; Pathological Conditions, Anatomical

Summary: prospective, non-randomized, multicenter post-approval study to collect long term clinical and echographic data on mitroflow dl patients.

the purpose of this clinical investigation is to evaluate the safety and efficacy of the mitroflow dl valve when used to replace diseased or dysfunctional native or prosthetic aortic heart valves. the study will be conducted in a minimum of 15 centers in the united states. patients will be evaluated at each of the following time intervals:preoperative, at implant, in the early postoperative period, at 1 year (between 11 and 13 months postoperatively), and annually for 8 years. the duration of the study is anticipated to be 8 years.

Eligibility criteria:
inclusion criteria: 1. patients is indicated for mitroflow dl implantation according to the instructions for use (ifu). 2. patient or patient's legal representative is willing to sign the informed consent. 3. patient's preoperative evaluation indicated the need for native or prosthetic aortic valve replacement 4. any patient amenable to aortic valve replacement with a biological prosthesis should be enrolled in the study, even in conjuction with valve repair, coronary artery bypass grafting and other procedures 5. patient is able to return for all follow-up evaluations for the duration of the study (geographically stable). exclusion criteria: 1. patient is contra-indicated for mitroflow dl implantation according to the instructions for use. 2. the patient has a pre-existing valve prosthesis in the mitral, pulmonary, or tricsupid position. 3. patient requires a double or triple valve replacement (repair is not considered an exclusion). 4. patient has active endocarditis or myocarditis. 5. patient is pregnant or lactating. 6. patient is participating in a concomitant research study of an investigational product.

Keywords: aortic valve replacement aortic stenosis aortic steno-insufficiency
effect of fetuin a in hemodialysis patients

Conditions: Hemodialysis; Malnutrition

Summary: the purpose of this study is to examined the effect of fetuin a on atherosclerosis and prognosis in hemodialysis patients.

fetuin a is known to be a potent inhibitor of ectopic calcification in plasma, and the concentration of fetuin a is closely associated with protein nutritional status. the purpose of this study is to examine whether the plasma concentration of fetuin a is associated with atherosclerosis and 5-year prognosis in hemodialysis patients.

Eligibility criteria:
inclusion criteria: * hemodialysis for at least 6 months exclusion criteria: * disabled patients

Keywords: atherosclerosis
correlation between preoperative refraction and anterior segment parameters with icl vault

Conditions: Refractive Errors; Myopia; Myopic Astigmatism

Summary: this prospective non-comparative interventional study aims to analyse the pre-operative factors affecting the range of optimal icl vaulting. the main question is what is the correlation between age, gender, spherical equivalent, white to white, anterior chamber volume and depth and postoperative vault? participants will do preoperative investigations ( specular microscopy, pentacam and biometry ) then refractive surgery (icl implantation) followed by follow-up visits to assess the post-operative icl vault and visual outcome.

procedure: refractive error correction by implantable contact lens ( icl) will be preceded by a preoperative assessment of the patient's anterior segment using specular microscopy, pentacam and biometry and full ophthalmic examination. post-operatively, visual acuity evaluation, intraocular pressure, and anterior and posterior segments examination using a slit lamp will be done on days 1 and 3 and then repeated after 1 month and 6 months assessment of icl vault measurement using pentacam scheimpflug imaging after 1 and 6 months will be done then a correlation between the icl vault and the patient's refractive error and preoperative anterior segments parameters will be evaluated

Eligibility criteria:
inclusion criteria: * age:21 - 45 years old. * high myopia or myopic astigmatism. * patients with stable preoperative refraction for the previous 12 months. * aqueous depth (acd internal) = 2.8 mm or greater from the endothelial side using pentacam. * patients who are not fit for lasik. * no previous intraocular surgeries. exclusion criteria: * patients with endothelial cell count \< 2800 cells /mm2 * patients with corneal opacities * patients with preoperative glaucoma, cataract, and retinal disease. * patients with any systemic diseases especially collagen diseases.

Keywords: refractive surgery phakic intraocular lens icl vault
effect of video-module based mindfulness training on physician stress and well being

Conditions: Stress; Burnout; Mindfulness Skills

Summary: an eight week mindfulness training for physicians in a community hospital setting, largely administered through web-casts, will decrease stress and burnout, increase job satisfaction, and develop lasting mindfulness skills in the participants.

the purpose of this study was to evaluate the impact of a video-module based mindfulness pilot program on the stress, well-being, and mindfulness skills of physicians in a community hospital setting. we administered an eight-week mindfulness training in october/november of 2013, offered as part of a wellness initiative for medical staff in a suburban community hospital in puyallup, washington. participants enrolled on a first-come, first-serve basis, engaging in three 90-minute in person trainings, weekly online video-module trainings, and weekly teleconference coaching calls. video-module trainings were available at all times, to be accessed at the participants' convenience. journals and a guided meditation audio library were also provided. physician stress, well-being (emotional exhaustion, depersonalization of patients, sense of personal accomplishment), and mindfulness skills (observing, describing, acting with awareness, accepting without judgment) were evaluated at baseline, end-of-program, and eight weeks post-intervention using well-validated instruments. risks to participants were minimal, including only the possibility of a strong emotional response to personal work undertaken by participants during the course of the study. the project was funded by multicare health system.

Eligibility criteria:
inclusion criteria: * gsh medical staff member exclusion criteria: * other multicare employees

Keywords: mindfulness
the riot trial: re-defining frailty and improving outcomes with prehabilitation for pancreatic, liver, or gastric cancer

Conditions: Adult Liver Carcinoma; Gastric Carcinoma; Malignant Solid Neoplasm; Pancreatic Carcinoma

Summary: this trial studies how well a prehabilitation program works to improve patient outcomes after surgery compared to the normal standard of care prehabilitation in frail patients undergoing surgery for pancreatic, liver, or gastric cancer. frailty is defined as the pathophysiology of aging or through the accumulation of physiologic and functional deficits. prehabilitation programs seek to optimize the medical and physical state of patients prior to undergoing surgery with the goal of improving outcomes following surgery. despite evidence for its importance in health outcomes for frail patients, prehabilitation programs have not been well studied in cancer surgery populations. this trial may provide researchers with more information on how to improve patient outcomes after cancer surgery through the use of prehabilitation programs.

primary objectives: i. to develop a novel, multi-dimensional index of physiologic reserve and resilience specific to surgical cancer patients. ii. to implement and assess a novel comprehensive multidimensional prehabilitation program on frail cancer surgery patients. outline: all patients enrolled (both frail and non-frail) will be randomized (1:1) at the time of enrollment to receive pre-operative exercise or non-preoperative exercises. randomization will be stratified by frailty status. arm i: enrolled patients undergo a physical therapy consultation and complete home exercises 3 days per week, in addition to standard guidelines. arm ii: enrolled patients follow standard guidelines. all patients are followed up at 2 weeks after surgery and then every 3 months.

Eligibility criteria:
inclusion criteria: * scheduled for any abdominal (e.g., pancreatic, liver or gastric) cancer surgery or established in the gi surgical oncology clinics or * scheduled for neoadjuvant therapy prior with the plan to be scheduled for surgery exclusion criteria: * non-english speaking * prisoners * persons unable to provide informed consent
preventing insomnia with virtual oneshot therapy (pivot)

Conditions: Insomnia

Summary: this study is intended to assess the efficacy of preventative cognitive behavioral therapy for insomnia (pcbt-i) on reducing the severity and stopping the progression of acute insomnia and depression. we also hope to gain a deeper understanding of the sociocultural, interpersonal, and individual factors that may have a role in development of insomnia and/or engagement with treatment plans.

insomnia is a debilitating condition that escalates the risk of a myriad of disorders and is a source of significant economic burden. insomnia takes an immense toll on individuals' physical and mental wellbeing and treating it before it can develop into chronic insomnia can save individuals untold time and money on treatment. this study is intended to assess the effects of one virtual pcbt-i session with a nurse coach on reducing the severity and stopping the progression of acute insomnia and depression. the benefits of pcbt-i have been demonstrated in prior studies but have yet to be tested on larger sample populations. participants will be recruited from the henry ford health system (hfhs) outpatient network, as well as the medicare/medicaid data warehouse and other community partners. subjects will be screened to determine eligibility, and then will be randomized into one of two insomnia treatment groups (control digital sleep education and pcbt-i via telehealth coaching). upon completion, the proposed research will not only have validated a preventative treatment for both insomnia and depression, but we will have the tools to apply it in the most effective way possible.

Eligibility criteria:
inclusion criteria: * individuals with low socioeconomic position as defined by income (\<35k annual household income) or education (high school diploma or less) * experiencing symptoms of prodromal acute insomnia (difficulty falling asleep, difficulty staying asleep, or problems waking up too early), along with worry or distress regarding their symptoms. exclusion criteria: * under the age of 18 * unwilling/unable to participate * conditions that could interfere with pcbt-i (including bipolar and seizure disorders) * untreated sleep disorders besides insomnia (e.g., sleep apnea, narcolepsy) * untreated and severe medical or psychiatric disorders

Keywords: insomnia depression digital nurse coaching cbt-i preventative therapy
discussion on the effectiveness of tea on blood pressure, body composition and vision problems in college students

Conditions: Myopia; Visual Fatigue; Blood Pressure; Body Composition; Body Fat

Summary: background: tea is a universal beverage and one of the most popular drinks around the world. some cell and animal experiments have pointed out that drinking tea may be related to hypotension, body composition and vision problems, and there are more and more related advertisements, especially for hibiscus tea, which is rich in anthocyanins. however, there is a lack of literature on the effectiveness of hibiscus tea drinks in preventing and treating blood pressure, body composition and vision problems in college students. purposes: this study used a randomized human trial to evaluate the effects of drinking hibiscus tea on the control and reduction of blood pressure, body composition, and near vision problems. 100 subjects were divided into 2 groups: the hibiscus tea group and the boiled water drinking group, and they continued to drink it for 10 weeks. at the beginning of the trial (week zero), the second week, the sixth week, and the tenth week after stopping drinking, the visual fatigue scale, blood pressure, and body composition were examined respectively. at the initial stage (0th week) and at the 10th week after stopping drinking, visual acuity examinations were performed. expected results: 1. to explore the effect of hibiscus tea drinks on subjects' myopia. 2. to explore the effect of hibiscus tea drinks on visual fatigue of subjects. 3. to explore the effect of hibiscus tea drinks on the blood pressure of subjects. 4. to explore the impact of hibiscus tea drinks on the body composition of subjects. 5. to explore the effect of hibiscus tea drinks on body fat of subjects.


Eligibility criteria:
inclusion criteria: * the inclusion criteria are college students aged 15 to 22 years old. - exclusion criteria: * hemodialysis patients who need to limit their water intake * those with a history of gastric ulcers * those allergic to anthocyanins * those who have long-term consumption or consumption of beverages, foods or health products containing high anthocyanins that may interfere with the study after evaluation, for example: foods or health foods such as cranberries, blueberries, cherries and grapes.

Keywords: roselle tea myopia college students body composition anthocyanin