Kornimate/medical-research-clean huggingface dataset:
mini-c-arm for distal radius fractures in adults

Conditions: Distal Radius Fracture

Summary: determine efficacy of the use of mini-c-arm fluoroscopy for the closed reduction of isolated distal radius fractures in adult patients in the emergency department setting.


Eligibility criteria:
inclusion criteria: * closed distal radius fracture requiring reduction exclusion criteria: * open, other ipsilateral upper extremity fractures, pregnant, incarcerated, less than 18 yo
effect of an apomorphine pump on the quality of sleep in parkinson's disease patients (pomprenelle).

Conditions: Parkinson's Disease

Summary: parkinson's disease is not only a pathology of movements. there are many non-motor symptoms that complicate and impair patients' quality of life. among those disorders are sleep disorders. insomnia is the most frequent symptom. most patients report 2-5 awakenings per night and long periods of awakening which occupy 30 to 40% of their night. apomorphine is a dopamine agonist that may be administered with a pump . the objective of the study is to assess changes in the quality of sleep in parkinson's disease patients treated with an apomorphine pump.


Eligibility criteria:
inclusion criteria: * parkinson's disease patients for whom a treatment with an apomorphine pump is indicated exclusion criteria: * atypical parkinsonian syndrome * cognitive impairment * pregnancy * breast feeding * patient under a legal protection procedure * patient denying to participate to the study * lack of affiliation to a social security system
trial of endometrial scratch prior to frozen embryo transfer in patients with recurrent implantation failure

Conditions: Recurrent Implantation Failure in Setting of Artifically Prepared Endometrium

Summary: patients with a history of recurrent implantation failure who are planning a frozen embryo transfer (fet) are enrolled into the program. patients are randomized to an endometrial biopsy prior to starting estrogen to prepare for the transfer of warmed vitrified embryos or to routine care.

patients who failed to achieve a clinical pregnancy after embryo transfer of at least three high quality embryos in at least two ivf or fet cycles and for whom their last failed cycle was a frozen embryo transfer are offered the opportunity to enroll in this study. all patients will follow our routine fet protocol. on a randomized basis, selected patients will undergo an endometrial biopsy using a pipelle disposable device in the week prior to starting estrogen to prepare her endometrium.

Eligibility criteria:
inclusion criteria: * at least two prior consecutive failed ivf or fet cycles with transfer of at least 3 high quality embryos and with last cycle a fet cycle exclusion criteria: * alternate explanation for implantation failure (e.g., intrauterine pathology)

Keywords: recurrent implantation failure frozen embryo transfer ivf endometrial scratch endometrial injury
prospective observational study of syncone® concept

Conditions: Jaw, Edentulous

Summary: the aim of this prospective observational study will be to evaluate patient-related outcomes, clinical, microbiological and peri-implant immunoinflammatory mediators in completely edentulous patients rehabilitated with delayed loaded overdentures prostheses. the investigators hypothetize that this system could restore edentulous patients with healthier mucosal concerning clinical, microbiological and immunoinflammatory parameters, besides to promote improvement in patient satisfaction and quality of life.

this prospective observational study will include fifteen edentulous patients rehabilitated with conventional dentures. patients will receive four to six maxillary implants loaded three months after surgery. clinical, microbiological and immunoinflammatory parameters will be evaluated at baseline, three, and six months following overdenture prosthesis. patient-centered/reported outcomes concerning general satisfaction with the prostheses as well as comfort, ability to speak, stability, esthetics, ease of cleaning and occlusion, will be evaluated at baseline (conventional denture evaluation) and after 6 months (overdenture evaluation).

Eligibility criteria:
inclusion criteria: * subject has total edentulous maxilla. * subject whose dental extractions occurred at least 6 months before treatment. exclusion criteria: * pregnancy, lactation, smoking or ex-smokers, systemic conditions that could affect bone metabolism (e.g., immunologic disorders, diabetes), use of anti-inflammatory, biphosphonate, and immunosuppressive medications, subjects that required bone grafts before/during implant surgery.
dynamic contrast enhancement computed tomography based technic to assess gastro intestinal wall perfusion : feasibility study

Conditions: Mesenteric Ischemia; Permeability CT Technics

Summary: this feasibility study has therefore several aims: 1. construct a dedicated ct perfusion protocol for git wall perfusion; 2. used a two-compartment pharmacokinetic model which is more adapted that a unique compartment model; 3. from the image acquired, evaluate current parameters of perfusion including the permeability ones


Eligibility criteria:
inclusion criteria: * all patients over fifty years old with clinico-biological suspicion for acute gitischemia admitted at our institution exclusion criteria: * contra-indication to contrast agent injection as so defined by the european society of uroradiology in 2014 * inability to provide informed consent
criteria and potential predictors of severity in patients with covid-19

Conditions: COVID-19

Summary: this is an observational cross sectional study included 202 patients diagnosed to have covid-19. the study was conducted at zagazig university isolation hospitals from the period of march 2020 to june 2021. the study was approved by zagazig university ethics committee (number 9229). a written informed consent was obtained from all participants. inclusion criteria: the study includes laboratory confirmed covid-19 patients (confirmed by real-time polymerase chain reaction) admitted l during the period of the study. the patients were classified into two groups, group a included mild/moderate cases, group b included severe/critical cases according to the following criteria. severity of covid-19 was graded as follows: mild; mild clinical symptoms, no pneumonia on lung ct; moderate: fever, cough and lung ct with pneumonia; severe: respiratory distress (respiratory rate \> 30 /min, oxygen saturation (o2sat) ≤ 93 percent at rest and/or ratio of arterial oxygen partial pressure to fractional inspired oxygen ≤300 mmhg (pao2/fio2); and critical: aforementioned criteria of respiratory failure receiving mechanical ventilation, shock, and/or organ failure other than lung and/or intensive care unit (icu) hospitalization. all participants were subjected to full history taking including smoking history and comorbidity profile. clinical symptoms including: fever, cough, dyspnea, myalgia, hemoptysis, sore throat, diarrhea, loss of smell and anorexia were recorded. radiological assessment by initial chest x ray then ct chest as possible and appropriate. routine laboratory investigations: complete blood count (cbc), coagulation profile, serum biochemical tests (including renal and liver function, and electrolytes), laboratory investigation to assess severity of covid-19: lactate dehydrogenase (ldh), myocardial enzymes (cpk-mb), serum ferritin, d dimer and arterial blood gases analysis. patients were followed up for the need for icu and mechanical ventilation (mv), duration till conversion, total length of stay and final outcome whether survived or died were recorded.


Eligibility criteria:
inclusion criteria: * laboratory confirmed covid-19 patients (confirmed by real-time polymerase chain reaction) admitted during the period of the study. exclusion criteria: * age less than 18 * refusal to participate * referral to other hospital within 24 hours of admission * missing data registry
the glycaemic effects of glucerna® in critically ill patients.

Conditions: Disorder of Glucose Regulation

Summary: to investigate whether the administration of glucerna achieves less glycaemic variability, defined as the mean absolute glucose (mag) change, and better glycaemic control compared to a standard high-carbohydrate enteral formula. continuous glucose monitoring technology will be used to evaluate glycaemic variability and glycaemic control.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years; * patients with an anticipated stay of at least 48 hours of admission to the intensive care * expected to receive enteral feeding for at least 48 hrs * indication for glucose regulation with insulin (according to the current glucose treatment protocol) * patient or surrogate understands and signs informed consent document. exclusion criteria: * patients with pre-existing contraindications to enteral feeding or to placement of a continuous glucose monitoring system * patients previously randomised into the glucip trial * any disease or condition which the investigator or treating physician feels would interfere with the trial or the safety of the patient.

Keywords: enteral nutrition continuous glucose monitoring
a study in children, teenagers and adults with severe hemophilia a who switched from other factor viii treatments to adynovate

Conditions: Hemophilia A

Summary: the main aims of the study are to assess the safety profile of adynovate as well as how well people respond to the preventive treatment with adynovate. this study is about reviewing and collecting data of the participants before and after the switch to adynovate that are already available. no new information will be collected during this study. the total time for data collection in the study will be approximately 72 months (36 months before and 36 months after switching to adynovate). participants will not receive adynovate as part of this study. as participants are not treated in this study, they do not need to visit their doctor in addition to their normal visits.


Eligibility criteria:
inclusion criteria: * participants with severe hemophilia a. * all age groups (less than \[\ \] 12 years of age). * participant with greater than equal to (\>=) 150 documented exposure days (eds). * treated with adynovate: * having a pk analysis done/data available for post-hoc modeling * having recorded clinical outcomes analysis: for \> 6 months * treated with a shl/ehl-fviii product for at least six months before switching to adynovate * to qualify for the secondary objective participants will need to have a wapps study performed on adynovate and on the shl/ehl-fviii they were treated before switching. exclusion criteria: * any participant who meets any of the following criteria will not qualify for entry into the study: * participants with only on-demand factor viii (fviii) use. * current presence of fviii inhibitory antibodies. (participants with a history of inhibitors, if any, will be considered for a sensitivity analysis). * diagnosis of other inherited or acquired hemostatic defect other than hemophilia a.
molecular mechanisms in malignant lymphoma- predict (mmml predict)

Conditions: DLBCL - Diffuse Large B Cell Lymphoma

Summary: the trial aims at the construction and validation of an accurate, affordable and simple prognostic tool to be used in everyday clinical practice, which allows the early and reliable identification of dlbcl patients who have a very high risk of treatment failure following r-chop/-like first-line therapy.

observational study of 500 recruited and 300 evaluable patients with de novo large cell b cell lymphoma, age 18-80. standard guideline recommended treatment by treating physicians discretion. collection of clinical data, pet-ct data, liquid biopsy, wgsequencing to determine optimal prognostic factors to surpass prediction offered by current ipi.

Eligibility criteria:
inclusion criteria: 1. histological diagnosis of dlbcl\&lbcl 2. planned treatment with guideline-based first-line therapy 3. patient's consent 4. all genders, patient age ≥ 18 years 5. ability to consent exclusion criteria: 1. treatment with r-chop/-like regimens already started 2. relationship of dependence/ direct employment with the investigator 3. active hiv-infection 4. presence history of other active cancers (with the exception of basal cell carcinoma of the skin)
autologous cord blood and human placental derived stem cells in neonates with severe hypoxic-ischemic encephalopathy

Conditions: Severe Hypoxic-ischemic Encephalopathy

Summary: the purpose of this study is to investigate the safety and effectiveness of autologous human placental-derived stem cells (hpdsc) in combination with autologous cord blood in neonates with severe hypoxic-ischemic encephalopathy.

the primary aim of this study is to determine the safety, tolerability and feasibility of intravenous administration of autologous cord blood (cb) and autologous human placental derived stem cells (hpdsc) in neonates with severe hypoxic-ischemic encephalopathy (hie). it is hypothesized that the administration of autologous cb and autologous hpdsc will be safe and well tolerated in neonates with severe hie. additionally, postnatal neuro-developmental outcomes in neonates with hie after autologous cb and hpdsc therapy will be measured; hie injury to the neonate/infant brain post autologous cb and hpdsc therapy by imaging will be characterized; the pluripotent stem cell properties of cb and hpdsc will be characterized; serum levels of selected circulating cytokine and neurotrophic factors in neonates with hie before and after autologous cb and hpdsc therapy will be compared and immune cell phenotype and function in neonates with hie before and after autologous cb and hpdsc therapy will be compared.

Eligibility criteria:
inclusion criteria: * gestational age ≥ 36 weeks * birth weight ≥ 1800 grams * postnatal age after birth of less than 6 hours * autologous cord blood and hpdscs available for infusion * plus one or more of the following criteria: apgar ≤ 5 at 10 minutes of postnatal age, or continued need for resuscitation ≥10 min after birth, or acidosis-cord blood ph or arterial blood ph within 60 minutes of birth ≤ 7.0 ph, or base deficit ≥ minus 16meq in cord blood and within 60 min of birth. * plus moderate to severe altered state of consciousness, by one or more of the following: hypotonia, or abnormal reflexes, or absent/weak suck. exclusion criteria: * major life-threatening or surgical anomalies * polycythemia (hematocrit \> 65%) * congenital infection based on antenatal diagnosis of torch infection * parental refusal for study * infant expected to live \< 24h, medical care is considered futile and no additional therapy will be offered by the attending neonatologist

Keywords: neonates hypoxic-ischemic encephalopathy human placental-derived stem cells autologous
using cardiac mri to characterise the dynamic changes which occur in the acutely reperfused stemi patient

Conditions: STEMI

Summary: there is an optimal day on which to perform the cmr scan which allows one to capture the information required to assess the dynamic changes in the reperfused stemi patient. the main objective is to characterise the dynamic changes in lv function, mi size, myocardial edema, mvo, imh, interstitial volume in the remote myocardium over the first 10 days of an acute reperfused stemi in order to identify the optimal day for performing the cmr scan.

this will be a prospective observational study with serial cmr imaging only. cmr scan each patient will receive one cmr scan performed on day 1, day 3, day 5, day 10 following the ppci procedure on a 3t philips scanner (see study flow below). all cmr scans will be analysed at a central cmr corelab. for day 1, 3, 5, 7 and 10 cmrs, parameters will be collected as follows: * left ventricle (lv) ejection fraction and indexed lv end systolic and diastolic volumes and mass using short-axis ssfp cine imaging and myocardial tagging sequences). * the aar by t1 and t2 mapping18 as a percentage of the lv over time. * signal intensity of t1 and t2 mapping in the mi zone, mi core and remote myocardium over time. * the incidence of intramyocardial haemorrhage (imh)(hypo-enhancement on t2\* mapping sequence)26. * the volume of microvascular obstruction (mvo) defined as signal intensity 2 standard deviated below the mean signal intensity of the remote myocardium on the t2\* maps. additional sequence for day 3 and 7 cmr scans: • all the above plus mi size (measured in mass of lge and expressed as a percentage of the lv mass).

Eligibility criteria:
inclusion criteria: 1. confirmed stemi as per ppci procedure reports/ clinical notes 2. proximal to mid coronary artery occlusion. 3. ability to provide informed consent exclusion criteria: 1. previous myocardial infarction or coronary artery bypass graft surgery 2. contraindication for cmr (e.g. ferromagnetic implants, claustrophobia, estimated glomerular filtration rate \<30ml/min)
a study of two approved drugs in patients with osteoarthritis (0966-220)(completed)

Conditions: Osteoarthritis

Summary: the purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of osteoarthritis of the knee.

the duration of treatment is 6 weeks.

Eligibility criteria:
inclusion criteria: * osteoarthritis of the knee which requires treatment with medication for pain relief exclusion criteria: * any known allergy to the study drugs
the effect of neuroscience pain education on quality of life in patients with chronic low back pain

Conditions: Chronic Low Back Pain; Quality of Life; Pain

Summary: manual therapy are among the therapeutic approaches frequently used in chronic low back pain (clbp). although most clinicians conduct patient education according biomedical model of pain, a relatively new approach which is referred to as neuroscience pain education (npe) is promising in patients with clbp. therefore the aim of this study was to investigate whether npe in patients with clbp who treated via manual therapy technique will produce different outcomes in terms of pain severity and qol compared to traditional patient education.


Eligibility criteria:
inclusion criteria: * volunteered to participate in the study. * patients with 18-65 years * had low back pain for at least 6 months, * reported pain severity of 5 or greater according to the numeric pain rating scale exclusion criteria: * previous spine or lower extremity surgery * severe osteoporosis * spondyloarthropathy * spondylolisthesis * lumbar stenosis * lumbar fractures * malign tumor

Keywords: manual therapy neuroscience pain education quality of life chronic low back pain
peek retentive elements versus conventional

Conditions: Partially Edentulous Mandible

Summary: comparing retention and patient satisfaction of implant-supported mandibular overdentures retained by conventional nylon clip and metal housings for ball attachments versus peek clip and housings

background. many patients suffer from lack of retention of conventional mandibular overdentures due to loss of clip retention over time. computer-aided design-computer-aided manufacturing (cad-cam) milled polyetheretherketone peek materials may be used for construction of retentive housing and clip for improving retention of implant-supported overdentures. objective . to compare retention and patient satisfaction of implant-supported mandibular overdentures retained by conventional nylon clip and metal housings for ball attachments versus peek clip and housings. methods: twenty-two participants were divided into 2 equal groups (n=11). the conventional group received implant-supported mandibular overdentures retained by metal housings and nylon retentive elements, while the peek group received implant-supported mandibular overdenture retained by peek retentive element and housings.the peek retentive elements were made by using computer-aided design and computer-aided manufacturing (cad-cam).evaluation included measuring the retention by applying a gradual pulling up force by forcemeter and patient satisfaction with a 7-point visual analog scale (vas) at overdenture insertion , 3,6, and 12 months subsequently by research interviewer.

Eligibility criteria:
inclusion criteria: * edentulous class i or ii pdi classification no neuromuscular disordersand temporomandibular joint disorders exclusion criteria: * exposed to radiotherapy

Keywords: ball attachment overdenture patient satisfaction peek retention measurement.
18f-fluoride (18f-naf) pet for identifying coronary atherosclerotic plaques

Conditions: Coronary Artery Disease; Atherosclerotic Plaque

Summary: the purpose of this study is to evaluate whether 18f-naf (sodium fluoride) positron emission tomography (pet) scans can be used to identify ruptured and high-risk plaque as compared to non-invasive coronary computed tomography angiography (cta) scans and high-definition intravascular ultrasound (ivus). in subsets of patients, 18f-naf pet scans and ccta will be repeated to assess scan-rescan reproducibility.

this research involves having cardiac 18f-naf pet imaging of the heart and coronary computed tomographic angiography (cta) in a one-day visit. three groups of patients will be enrolled: patients with acute coronary syndrome, patients with stable ischemic heart disease, and asymptomatic patients with suspected coronary artery disease. prior to 18f-naf administration, participants will have blood drawn to measure serum creatinine and other biomarkers related to heart disease. all participants will undergo a 18f-naf pet scan and a coronary cta (which includes contrast administration). if medically appropriate, participants will have oral or intravenous beta-blocker (metoprolol) and nitroglycerin prior to cta imaging. up to 10 patients will be asked to return for repeat18f-naf pet and coronary cta imaging 2 to 21 days after the initial scan. up to 20 patients will be asked to return for repeat 18f-naf pet scan and coronary cta imaging about 6 months after the initial scan. researchers will compare the repeat images to the initial studies.

Eligibility criteria:
inclusion criteria: three groups of patients will be recruited for this study. 1. acute coronary syndrome group: 40 patients with type 1 myocardial infarction within 21 days prior to the imaging visit and invasive coronary angiography with angiographic evidence of at least a 50% stenosis in one or more coronary arteries. only patients undergoing pci will be included in the study. 2. stable ischemic heart disease group: 40 patients who have undergone invasive coronary angiography within 21 days prior to the imaging visit, with history of typical angina prior to the angiogram, but no prior myocardial infarction or coronary revascularization. 3. asymptomatic cad group: 40 patients who have undergone coronary artery calcium scanning within 6 months prior to the imaging visit, matched to the acs patients for age, gender, and cac score. * patients in the asymptomatic cad group must * have no prior cad associated event (no prior myocardial infarction, acute coronary syndrome, coronary angiogram, or pci), * have cac between 10 to \<1000, and * match to patients in the acs group by gender, age by decile, and cac category (using cac categories of 10 to \<100, 100 to \<400, 400 to \<1000). exclusion criteria: * age \< 18 years * creatinine \> 1.5 mg/dl * history of severe allergy to iodine contrast agents * pregnancy * active atrial fibrillation * multiple premature ventricular or atrial contractions * ejection fraction \<35% * class iii congestive heart failure

Keywords: 18f-naf pet 18f-sodium fluoride pet coronary cta