Kornimate/medical-research-clean huggingface dataset:
relationship between spinopelvic parameters and clinical symptoms of low-grade lumbar isthmic spondylolisthesis

Conditions: Isthmic Spondylolisthesis

Summary: this was a retrospective study.pi and ll greatly influence is and its progression. however, relationships between the spinopelvic parameters and clinical symptoms of patients with is were not fully investigated in previous studies. investigators hypothesized that spinopelvic parameters might be related to the clinical symptoms of is patients. therefore, the purpose of the present study was to investigate whether differences in spinopelvic parameters, especially spinopelvic alignment, may be associated with the clinical symptoms of low-grade is patients.

isthmic spondylolisthesis (is) is one of the most common types of spondylolisthesis, and spinopelvic parameters are closely related to the clinical symptoms of spinal diseases. in this study, investigators attempted to investigate the relationship between spinopelvic parameters and clinical symptoms of patients with low-grade (meyerding grade i-ii) isthmic spondylolisthesis (is). a total of 120 patients with low-grade is and 106 asymptomatic adults were included in this study. sex, age and body mass index (bmi) were also collected. various spinopelvic parameters were evaluated in whole-spine standing-position x-rays. the following spinopelvic parameters were measured: pelvic incidence (pi), sacral slope (ss), pelvic tilt (pt) and lumbar lordosis (ll). the clinical symptoms of the is patients were assessed with the japanese orthopaedic association (joa) score and the visual analogue scale (vas). investigators compared spinopelvic parameters between the asymptomatic adults and the is patients. additionally, investigators investigated correlations between spinopelvic parameters and clinical symptoms.

Eligibility criteria:
inclusion criteria: * isthmic spondylolisthesis subjects had spondylolisthesis at l4 or l5 (meyerding grade i-ii) with whole-spine standing lateral images exclusion criteria: * spondylolisthesis of other types (degenerative, dysplastic, etc.); * lumbar infection and/or tumor diseases; * a previous history of lumbar fusion surgery.

Keywords: isthmic spondylolisthesis spinopelvic parameter clinical symptom pelvic incidence lumbar lordosis
evaluation of universal prevention curriculum for schools in peru

Conditions: Substance Use

Summary: this randomized controlled trial was conducted to evaluate a universal prevention curriculum (upc) training for peruvian school administrators and teachers to reduce substance use among students. twenty-eight schools were randomly assigned to intervention and control conditions (14 per condition). substance use outcomes were assessed with repeated cross-sectional samples of students in 2018 and 2019. multi-level analyses were conducted to assess intervention effects on students' substance use and related problems.

this randomized controlled trial was conducted to evaluate a universal prevention curriculum (upc) training for peruvian school administrators and teachers to reduce substance use among students. twenty-eight schools were randomly assigned to intervention and control conditions (14 per condition). prevention leadership action teams were formed at intervention schools to implement evidence-based school policies and positive school climate activities, and a classroom substance use prevention curriculum. substance use outcomes were assessed with repeated cross-sectional samples of students in 2018 and 2019. multi-level analyses were conducted to assess intervention effects on students' substance use and related problems.

Eligibility criteria:
inclusion criteria: * students in participating schools aged 11 to 19 exclusion criteria: * not attending participating schools
evaluation of efficacy and safety of medi2070 in patients with active, moderate-to-severe crohn's disease.

Conditions: Crohn's Disease

Summary: the study is designed to evaluate the clinical efficacy and safety of medi2070 as compared to placebo. investigational product will be administered as intravenous infusion in double-blind period, and as a subcutaneous injection in open-label period

this is a two-part phase 2a study compromising a 12-week, double-blind, placebo-controlled, treatment period followed by a 100-week, open label, treatment period to evaluate short-term efficacy, and the short- and long-term safety of medi2070 in subjects with moderate to severe, active cd who have failed or are intolerant to anti-tnfα therapy as determined by the investigator. approximately 120 subjects will be randomized in a 1:1 ratio to initially receive a fixed iv dose of medi2070 or placebo on week 0(day1) and week 4 (day 29) during the 12-week, double-blind, placebo-controlled, treatment period. at the completion of the double-blind, placebo-controlled, treatment period (week 12), subjects will have the option to enter a 100-week, open-label, treatment period where they will receive open-label medi2070 (sc) q4w (week 12 through week 112). subjects will be followed for safety at 3 visits over 28 weeks after their last dose of ip. subjects will also be contacted by phone 36 weeks after their last dose of ip for safety.

Eligibility criteria:
inclusion criteria: * diagnosed ileal, ileo-colonic, or colonic cd at least 6 months prior to screening. * men or women age 18 - 65 years at the time of screening. * moderate-sever active crohn's disease (cd), defined by a crohn's disease activity index (cdai) score higher or equal 220 and lower or equal 450 at day 1. * no known history of active tuberculosis (tb). * received at least one anti-tnfα agent for the treatment of cd and did not initially respond. exclusion criteria: * pregnant or breastfeeding women. * presence of ileostomy and/or colostomy. * short bowel syndrome. * bowel perforation or obstruction. * history of cancer.

Keywords: medi2070 inflammatory bowel disease moderate to severe crohn's disease
expression analysis of the copb 2 and bcl-2 in early stages of endometrial carcinoma

Conditions: Endometrial Carcinoma Cellular Diagnosis

Summary: copb2 is a subunit of the intracellular transport system between cell organelles that participates in the regulation of cell division and differentiation. bcl-2 is a protein that participates in regulating the process of apoptosis. through the research,investigators tried to examine and establish the correlation of the expression of these two genes in endometrial cancer at an early stage.

the research was conducted as a prospective controlled clinical experimental study in the period from 2019-2022. in patients who were treated at the gynecology and obstetrics clinic in clinical center kragujevac. sections of tissue deriving from the exploratory curettage and operative procedure were taken after obtaining informed consent of participants with the declaration of helsinki and recommendations of the world health organization for experiments on human material and after getting approval of the ethics committee. participants are divided into two groups. investigators stored the sample (endometrial tissue) in liquid nitrogen under adequate conditions at the kragujevac clinical center, department for gynecology and obstetrics and examined the expression of the copb2 and bcl-2 gene in endometrial tissue cells of these two groups of patients. in order to examine the relative expression of the gene for the copb2 subunit and bcl-2, investigators sampled endometrial tissue from patients with endometrial cancer - experimental group and from patients without cancer - control group. all participants of the experimental group had initial stages of cancer, without the existence of metastases at the time of taking the sample for the study. gene expression was performed using the polymerase chain reaction method at the faculty of science and mathematics in kragujevac.

Eligibility criteria:
inclusion criteria: * signed informed consent of the patient * pathohistological confirmation of endometrial carcinoma for the experimental group * normal endometrial tissue and hyperplasia simplex endometrii for the control group. exclusion criteria: * malignant disease in the patient whose treatment is still ongoing * pathohistological determination of atypical hyperplasia of the endometrial tissue

Keywords: carcinoma endometrii apoptosis relative expression copb2 relative expression bcl-2 polymerase chain reaction
radiation therapy plan quality improvement using ideal theoretical isodose distribution

Conditions: Head and Neck Neoplasms

Summary: the researchers hope that based on the study findings future patients may benefit from a more precise radiation treatment plan that can be developed more quickly and thus decrease the time from computerized tomography simulation to start of treatment.

as part of this study participants will receive the standard of care treatment for all head and neck cancer patients. the researchers plan to use a software program to see if it will assist in developing the best radiation treatment plan possible. the researchers will also measure the quality of each treatment plan so areas of improvement can be identified.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years. * ability to provide informed written consent in either english or spanish. * patient planned to undergo radiation therapy for head and neck cancer. exclusion criteria: * current pregnancy, as this is a contraindication to receiving radiation therapy. * history of prior radiotherapy to the head and neck. * any condition or history as evidenced by patient record and/or self-report that, in the opinion of the investigator, would interfere with adherence to daily radiation therapy.
sustainable and healthy return-to-work program - praticadr 2.0

Conditions: Common Mental Disorder

Summary: this study aims to assess the effectiveness of praticadr 2.0, a web application facilitated by a return-to-work coordinator (rtw-c), with a focus on reducing sick leave duration and preventing relapse in individuals with cmds. praticadr 2.0 designed to enhance collaboration among return-to-work (rtw) stakeholders and provide systematic support throughout the rtw process, is evaluated in a randomized control trial (rct). as part of the rct, a total of 80 sick leave employees from 4 large public health organizations (n=80, 40 from the experimental group and 40 from the control group) will be recruited. the control group receives usual services offered by a rtw-c to sick leave employees, while the experimental group receives rtw-c services plus the use of praticadr 2.0.

common mental disorders (cmds) are highly prevalent in workplace settings, and have become a significant public health challenge. this study aims to assess the effectiveness of praticadr 2.0, a web application facilitated by a return-to-work coordinator (rtw-c), with a focus on reducing sick leave duration and preventing relapse in individuals with cmds. praticadr 2.0 designed to enhance collaboration among return-to-work (rtw) stakeholders and provide systematic support throughout the rtw process, is evaluated in a randomized control trial (rct). as part of the rct, a total of 80 sick leave employees from 4 large public health organizations (n=80, 40 from the experimental group and 40 from the control group) will be recruited. the control group receives usual services offered by a rtw-c to sick leave employees, while the experimental group receives rtw-c services plus the use of praticadr 2.0. participants will be randomly assigned to either the praticadr 2.0 experimental group or the control group using computerized stratified randomization based on age, site, and sex (sealed envelope method). participants will complete a series of online questionnaires at several following time points. survival analyses were used to compare sick leave durations and relapses between the experimental group (praticadr with rtw-c), and control groups (rtw-c only). mixed linear models were used to observe changes in clinical symptoms over time, especially for the experimental group.

Eligibility criteria:
inclusion criteria: * sick leave due to common mental disorder (i.e. depression, anxiety, adjustment disorder, burnout) * sick leave duration (from 1 to 3 months) * member of participating unions in the large health organization exclusion criteria: * inability to communicate in french * have a known organic disorder * have a professional dirsorder (cnesst) * have experienced previous sick leaves due to common mental disorder

Keywords: return to work sick leave duration relapses clinical symptoms
cbt program for pain management for children and youth with cp (cbt=cognitive behavioral therapy; cp= cerebral palsy)

Conditions: Cerebral Palsy; Chronic Pain

Summary: this study will focus on the feasibility of a modified cognitive behavioral program for pain management among children and youth with cerebral palsy (cp) on developing pain coping skills and reducing pain interference levels the study design is a randomized control feasibility trial. participants will be placed randomly into one of two groups based on chance (50/50). the 2 groups are: (1) immediate treatment group and (2) delayed wait-list treatment group. both groups will receive the same intervention protocol.

children with cp often experience pain that is related to their medical condition and that may limit or interfere with their everyday activities and quality of life (qol).one possible way to help these children is by using a modified cognitive behavioral therapy (cbt) for pain management. for this study, the investigators want to do a feasibility study, to see if participating in a six-week pain management cbt program for children and youth with cp and their parents, leads to better pain coping skills and lower levels of pain interference, when compared to a controlled waiting list. participants in both groups (immediate and delayed treatment) will participate in a 2-hour cbt session, once a week, for a total of six weeks. following 3-months from the last cbt session, participants will be contacted for a short follow-up screening. all participants will be enrolled in the study for a total of 18 weeks. this study will be done at the holland bloorview kids rehabilitation hospital, toronto, canada. sixteen participants with cp (gross motor function classification system (gmfcs) levels i-v), age 8 to 18, with evidence of chronic pain (detailed as pain lasting more than 3 months or lasting longer than the expected time to heal) and their parents, will be recruited for participation.

Eligibility criteria:
inclusion criteria: 1. diagnosis of cp 2. chronic pain lasting greater than 3 months and restricting some or all activities according to child/youth/parental self-report 3. a baseline score of 70 (\~ -2 sd) on each of the three vineland adaptive behavior scales (vabs) sub-scales: communication, daily living skills and socialization 4. successful completion of a modified sorting task including sorting cubes according to size and rating activities in order of how much they like to do them 5. parent agreement to participate in the parents' program 6. can communicate in english, with or without the use of augmentative communication devices exclusion criteria: participants who meet any of the following criteria will not be eligible to take part in the trial: 1. diagnosis of major visual or hearing impairment 2. currently attending psychological treatment focused on pain management; (3) uncontrolled seizure(s) (with or without medication) in the previous 12 months.

Keywords: cognitive behavioral therapy
the cronos-adm registry

Conditions: Asymptomatic Patients With Type 2 Diabetes Mellitus; Atherosclerosis; Coronary Artery Disease; Cardiovascular Disease

Summary: the cronos-adm (coronary ct angiography evaluation for clinical outcomes in asymptomatic patients with type 2 diabetes mellitus) registry is a large, prospective observational registry of demographic, clinical and laboratory data with long-term clinical outcome of asymptomatic diabetic patients without history of cad or angina or angina-equivalent symptoms at two affiliated hospitals of the catholic university of korea.


Eligibility criteria:
inclusion criteria: 1. age \> 18 years 2. asymptomatic type 2 diabetes mellitus 3. prospective data collection for cad risk factors
detection and biopsy guidance of nasopharyngeal carcinoma based on artificial intelligence and endoscopic images

Conditions: Nasopharyngeal Carcinoma; Image-Guided Biopsy

Summary: due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperplasia, the positive rate for nasopharyngeal carcinoma identification during biopsy is low, thus leading to delayed or missed diagnosis for nasopharyngeal carcinoma upon initial attempt. here, we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies and guide biopsy under endoscopic examination based on deep learning.

due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperplasia, the positive rate for nasopharyngeal carcinoma identification during biopsy is low, thus leading to delayed or missed diagnosis for nasopharyngeal carcinoma upon initial attempt. here, we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies and guide biopsy under endoscopic examination based on deep learning.

Eligibility criteria:
inclusion criteria: * the patient was found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy and the clinicans considered it necessary to perform an biopsy. * hemilateral lesion with limited size. exclusion criteria: * patients with nasopharyngeal cancer, oropharyngeal cancer, hypopharyngeal cancer, etc. who have already been treated.

Keywords: artificial intelligence classification nasopharyngeal carcinoma nasopharyngoscope image-guided biopsy
comparison of the effectiveness of functional training versus resistance exercises in patients with psoriatic arthritis

Conditions: Psoriatic Arthritis

Summary: the aim of this study was to assess the effectiveness of functional training versus resistance training in improving functional capacity, muscle strength, quality of life and disease activity in patients with psa.

the functional training group (ft) used elastic bands and the resistance exercise group (re) used weight training machines. the ft patients performed functional training and re performed resistance exercises for the following muscles group: upper limbs, lower limbs and trunk. it was used a machine "leg extension" for the training on the lower limbs. for upper limbs the investigators used a pulley triceps machine and front pull in addition to free weights (dumbbells). in order to perform the exercise program, the study followed all the recommendations established by the american college of sports medicine (acsm) (ratamess et al., 2009). it was carried out two exercises for major muscle groups and one exercise for small muscles. the exercises were divided in 3 sets of 12 repetitions for each muscle group. the intensity of the exercises was 60% of one-maximum repetition (1rm). the exercise program involved pectoral exercises: crucifix and seat supine; biceps: alternated screw; triceps: triceps pulley; back: standing handsaw and pulled ahead; quadriceps: leg extensor and finally gluteus: standing hips extension. the patients were instructed to maintain their daily activities and to avoid any other nonpharmacological treatment.

Eligibility criteria:
inclusion criteria: confirmed diagnosis of psoriatic arthritis, according to the caspar criteria * between 18 and 65 years of age, of both genders who agreed and signed the consent form. * patients should be-modifying drugs (dmards) on stable doses for at least three months and doses of non-steroidal anti-inflammatory drugs and corticosteroids stable for at least 4 weeks exclusion criteria: * patients were excluded: * uncontrolled cardiovascular disease * decompensated diabetes mellitus; diseases * severe psychiatric * fibromyalgia * other medical conditions that most disabling ea * history of regular exercise (at least 30 minutes 2 times per week) during the last 6 months * arthroplasties of the hip and / or knee in the last 12 months; and * any other medical condition that prevents the patient from performing resistance exercises

Keywords: functional training physical exercise psoriatic arthritis quality of life
ultrasound guided tap block versus caudal block in pediatrics

Conditions: Anesthesia

Summary: the use of pediatric regional anesthesia has increased because of its effective pain control, improved safety profile of local anesthetic agents, in addition to the introduction of ultra-sound. at present, caudal block is one of the most common regional anesthetic techniques employed in pediatric surgery. in addition to providing postoperative analgesia, caudal block significantly reduces intraoperative analgesic requirements and upper airway complications. transversus abdominis plane (tap) block involves infiltration of local anesthetics to the plane between the internal oblique and transversus abdominis muscles. indeed, tap block offers a hemodynamic stability, appropriate intra-operative analgesia and post surgical analgesia of the abdominal wall.

the use of pediatric regional anesthesia has increased because of its effective pain control, improved safety profile of local anesthetic agents, in addition to the introduction of ultra-sound. at present, caudal block is one of the most common regional anesthetic techniques employed in pediatric surgery. in addition to providing postoperative analgesia, caudal block significantly reduces intraoperative analgesic requirements and upper airway complications. however, in recent days there is a trend toward the use of peripheral nerve blockade wherever applicable, given the lower incidences of adverse effects when compared with neuron-axial techniques. furthermore, there may be specific anatomic variations or abnormalities which preclude the use of caudal block. the abdominal wall consists of three muscular layers, the external oblique abdominis muscle (eoam), the internal oblique abdominis muscle (ioam), and the tranversus abdominis muscle (tam), and their associated fascial sheaths. the central abdominal wall also includes the rectus abdominis muscles and its associated fascial sheath. this muscular wall is innervated by nerve afferents that course through the transversus abdominis neuron-fascial plane. transversus abdominis plane (tap) block involves infiltration of local anesthetics to the plane between the internal oblique and transversus abdominis muscles. indeed, tap block offers a hemodynamic stability, appropriate intra-operative analgesia and post surgical analgesia of the abdominal wall.

Eligibility criteria:
inclusion criteria: * asa (american society of anesthiologists) physical status grade i-ii. * operations not extending more than two hours. * unilateral surgeries. exclusion criteria: * refusal of parents. * urgent cases. * bilateral or complicated hernias (i.e., obstructed, strangulated, irreducible ...). * other contraindication of regional anesthesia e.g. septic focus at site of injection, patients on anticoagulant therapy or suffering from coagulopathy, allergy to local anesthetic drug. * prolonged operations more than two hours.