Kornimate/medical-research-clean huggingface dataset:
assessing benefits and harms of cannabis/cannabinoid use among cancer patients treated in community oncology clinics

Conditions: Breast Carcinoma; Colorectal Carcinoma; Lung Non-Small Cell Carcinoma; Melanoma; Non-Hodgkin Lymphoma

Summary: this is a multi-site clinical study enrolling 2000 newly diagnosed patients with breast, colorectal, melanoma, non-hodgkin lymphoma, or non-small cell lung cancer, who are planning to receive one or more systemic cancer directed therapies with chemotherapy and/or (immune checkpoint inhibitors) icis.

the objective of this study is to examine the association between cannabis and/or cannabinoid use and cancer-related symptoms assessed monthly for one year in adults newly diagnosed with breast, colorectal, melanoma, non-hodgkin lymphoma, or non-small cell lung cancer who are planning or recently started to receive one or more systemic cancer directed therapies with chemotherapy and/or immune check point inhibitors (icis) targeting pd-1, pd-l1 or ctla-4. participants complete surveys and have their medical records reviewed on study.

Eligibility criteria:
inclusion criteria: * adults aged 18 years or older with one of the following newly diagnosed cancers: breast cancer, colorectal cancer, melanoma, non-hodgkin lymphoma, or non-small cell lung cancer. * planned treatment with systemic chemotherapy (single or multi-agent, includes targeted therapy) and/or immune checkpoint inhibitor therapy (targeting pd-1, pd-l1 or ctla-4). if unable to engage participant before treatment starts, enrollment is allowed up to the start of cycle 2 treatment. * participants must be able to comprehend english or spanish (for survey completion). * participants must have a working email address and be must be willing to complete surveys online. this can be completed at home, in the clinic or other location. * completion of the confidential self-reported screening survey and receipt of a screening result - eligible for enrollment. optional sub-study (available at select sites only): * must be willing to participate in both the main study and the sub-study at the wake forest university comprehensive cancer center (wf ccc) and virginia commonwealth university (vcu). * must be receiving treatment at the wf ccc and vcu. * must be diagnosed with non-small cell lung cancer. * must be receiving paclitaxel as part of their chemotherapy in conjunction with immune checkpoint inhibitor (icis) pd-1, pd-l1 or ctla-4. * must be enrolled and complete baseline survey before cycle 1 begins exclusion criteria: * currently enrolled in an interventional supportive treatment trial to manage cancer symptoms. * participants with known pregnancy. optional substudy (available at select sites only): * participants with chronic or ongoing steroid or immunomodulatory agents (i.e., prednisone, dexamethasone, etanercept, infliximab, etc.). the use of glucocorticoids as pre-medications for chemotherapy treatment is allowed. * participants with a history of hiv, hepatitis b or hepatitis c.
vascularity of the ulna and its association with forearm nonunion

Conditions: Forearm Fracture

Summary: non-union after operative treatment of an ulnar fracture is very uncommon. there are severely disabling and challenging to treat. multiple factors have been associated with the establishment of this non-union. many non-unions are associated with soft tissue damage, fracture site vascularity, persistent instability, infection, and the surgical treatment technique. this study analysed the systemic conditions and local factors associated with the failure of bone fracture healing the aim of our study was to identify the risk factors for ulnar nonunion

in the anatomical study we investigated the extraosseous and intraosseous blood supply in fourteen specimens from the department of human anatomy. we correlated the areas with a low vascularity with the usual areas that patients have ulnar nonunion. in the clinical study we retrospectively reviewed a cohort of ulnar fractures treated surgically with open reduction and internal fixation (orif), during a period of 10 years (2007-2016). we identified 211 ulnar fractures. all patients had a minimum follow-up of 1 year. we defined non-union if there was no radiological consolidation of the fracture after this period, and we classified them according to weber classification. we assessed risk factors like: fracture site vascularity, surgical treatment technique, biological factors of the patient, and the fracture's mechanism. we correlated data and associated risk factors from the anatomical and the clinical studies. data were analysed using spss software system version 21. multivariate regression analysis was performed to assess independent risk factors of ulnar non-union. chi square test or fisher exact test was used to compare categorical measurements. statistical significance was considered as p less than 0.05.

Eligibility criteria:
inclusion criteria: * adults from 18 to 90 years old * forearm ulnar nonunion exclusion criteria: * children * other types of forearm fractures
transcutaneous bilirubin measurements in neonates post phototherapy

Conditions: Jaundice, Neonatal

Summary: can transcutaneous bilirubin (tcb) measurements be utilised to assess rebound hyperbilirubinaemia following phototherapy in neonates?

jaundice is common in the newborn and may result in the need for babies to be readmitted from home for phototherapy, with associated increased costs and significant family distress. as well as prolonged hospital stay, neonates on phototherapy require multiple blood tests (sbr), generally acquired via heel prick testing. these cause the baby discomfort and samples may be insufficient or haemolyzed and require repeating. there is also a delay of one to two hours at best in results being received and actioned. jaundice measurements can also be obtained using non-invasive, cheap and reliable meters (tcb) that give almost immediate results. the meter takes one to two minutes to get a result and can be used at the cotside. tcb causes the baby no significant discomfort. tcb meters are commonly used before phototherapy but are not routinely used during or after stopping phototherapy. jaundice commonly worsens after stopping phototherapy due to release of bilirubin from tissues and so measuring a "rebound" sbr twelve hours after stopping phototherapy and before the baby can go home is routine practice. tcb meters tend to underestimate sbr in the first eight hours after stopping phototherapy but there is some evidence that thereafter they may provide reliable results. if tcb measurements can be used as a reliable predictor for sbr twelve hours after phototherapy, this will reduce blood sampling and costs, causing less distress to the baby and their mother, with potential for earlier discharge home. the nice guideline for neonatal jaundice suggests that new research is needed to evaluate the accuracy of different transcutaneous bilirubinometers in comparison to serum bilirubin levels in all babies.

Eligibility criteria:
inclusion criteria: * well neonates * 35+0 weeks gestation or greater, over 24 hours old * inpatients at princess royal maternity (prm), nhs greater glasgow and clyde exclusion criteria: * unwell neonates * less than 35+0 weeks' gestation * less than 24 hours old * mother unable or too distressed to give informed consent

Keywords: jaundice neonate transcutaneous phototherapy bilirubin
two techniques for root coverage with a xenogeneic collagen matrix

Conditions: Gingival Recession

Summary: gingival recessions are often successfully treated by coronally advanced flap technique (caf) associated with subepithelial connective tissue grafts (sctg). currently the xenogeneic collagen matrix (cm) has been used as a substitute for sctg associated with caf technique for root coverage. caf technique was not developed for use with cm and has shown limited results when applied to the cm. the aim of this study was to compare and show the benefits of the extended flap technique (eft) compared to caf technique using cm for root coverage.


Eligibility criteria:
inclusion criteria: * ages 25 to 50 years old * bilateral gingival recession type miller class i or ii * with 3 mm in height and less than 3mm of keratinized tissue * non-molar teeth exclusion criteria: * diabetics * pregnant women * chronic use of medication * periodontitis

Keywords: root coverage gingival recession periodontal surgery
identification of new markers in the hypereosinophilic syndrome

Conditions: Hypereosinophilic Syndrome

Summary: the purpose is to characterize new hypereosinophilic syndrome biomarkers more informative and more accessible compared to those that we have already thanks to a proteomic approach. this will help the investigators to diagnose the this disease.


Eligibility criteria:
inclusion criteria: * dated and signed informed consent * virale serology negative or negative result less than 6 months * virale serology negative for hbv or vaccinated patient * insured * virale serology negative or negative result less than 6 months * negative pregnancy test or female menopause for at least 1 year exclusion criteria: * subject enable adult, under guardianship or under protective measures of justice * refusal or inability to give informed consent * the hypereosinophilic syndrome explained origin other than than atopy, bullous pemphigoid, the churg-strauss syndrome and dress
cerclage after full dilatation caesarean section

Conditions: Preterm Birth; Preterm Premature Rupture of Membrane; Preterm Spontaneous Labor With Preterm Delivery

Summary: craft-obs: observational study; to evaluate subsequent pregnancy risk of preterm birth in women with a history of previous caesarean in established labour. this prospective study using clinically acquired cervical length and quantitative fetal fibronectin data will help establish a predictive model of preterm birth \<34 weeks and \<37 weeks. craft-rct: randomised controlled trial arm; to assess treatment for short cervix in women at high risk of preterm birth following a caesarean section at full dilatation craft-img: imaging sub-study; to aid understanding of micro and macrostructural features within the cervix which predisposes to preterm birth in women with a previous full dilatation caesarean section. this will use mri and an advanced transvaginal ultrasound protocol and to assess if structural changes can be visualised in the cervix.


Eligibility criteria:
craft-obs inclusion criteria: * pregnant women under 23+6 weeks gestation with a history of previous caesarean section in labour. * singleton pregnancy. * willing and able to give informed consent (with or without interpreter). exclusion criteria: * under 16 years of age. * inability to give informed consent. * previous caesarean section carried out before labour. * women who have been commenced on management with progesterone, a cerclage or arabin pessary as part of their care or another research study craft-rct: inclusion criteria: * pregnant women up to 23+6 weeks gestation with a history of fdcs. * short cervix (\<=25mm) on transvaginal ultrasound scan. exclusion criteria: * women with persistent fresh vaginal bleeding evident on speculum examination. * women with visible fetal membranes evident on speculum examination or open cervix on ultrasound scan. * women with severe abdominal pain/evidence of sepsis (as judged by attending clinician). * known significant congenital or structural or chromosomal fetal abnormality. * suspected or proven rupture of the fetal membranes at the time of recruitment. craft-img inclusion criteria: * pregnant women between 14+0 and 23+6 weeks gestation with a history of fdcs. exclusion criteria: * contraindications to mri, e.g. claustrophobia, bmi \>40 kg/m2 (due to technical limitations of scanner) or a women with a non-mri compatible metallic implant.
mri fdg pet imaging cervix

Conditions: Cervical Cancer Squamous Cell

Summary: the standard treatment for cervix cancer at princess margaret hospital is external radiation with chemotherapy followed by internal radiation, called brachytherapy. currently, brachytherapy treatment is planned on a type of magnetic resonance imaging (mri) called t2-weighted (t2w) mri. the main purpose of this study is to determine whether the following imaging tests can visualize the tumor better for planning the brachytherapy treatment: 1. special types of mri called diffusion weighted mri (dwi) and dynamic-contrast enhanced mri (dce-mri); and 2. an x-ray test called positron emission test (pet) performed with a sugar dye called fdg. mri-guided brachytherapy is resource-intensive and not widely available.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years 2. histologic diagnosis of squamous cell carcinoma, adenocarcinoma or adenosquamous carcinoma of the cervix 3. figo stage ib - iva 4. intention to treat using radiotherapy with or without concurrent cisplatin chemotherapy according to the current treatment policies of the pmh gynecology group 5. intention to treat with mr-guided brachytherapy as part of standard radiotherapy according to the current treatment policies of the pmh gynecology group 6. no cytotoxic anti-cancer therapy for cervix cancer prior to study entry 7. a negative urine or serum pregnancy test within the two week interval immediately prior to the first pet-ct imaging, in women of child-bearing age 8. ability to provide written informed consent to participate in the study exclusion criteria: 1. prior complete or partial hysterectomy 2. carcinoma of the cervical stump 3. inability to lie supine for more than 30 minutes 4. insulin-dependent diabetes mellitus 5. impaired kidney function with glomerular filtration rate \< 30 6. previous anaphylactic reaction to gadolinium or other contraindications to mr.

Keywords: cervical cancer pet scan for cervix mri for cervix
treatment of dravet syndrome with fenfluramine (expanded access protocol)

Conditions: Dravet Syndrome

Summary: the purpose of this research study is to (1) provide access to fenfluramine for patients with intractable epilepsy associated with dravet syndrome, and (2) evaluate the safety of fenfluramine.

the purpose of this research study is to (1) provide access to fenfluramine for patients with intractable epilepsy associated with dravet syndrome, and (2) evaluate the safety of fenfluramine.

Eligibility criteria:
inclusion criteria: * genetic diagnosis of dravet syndrome with intractable seizures despite failing all available medications for seizures.
understanding the mental health of migrant workers during the covid-19 outbreak

Conditions: Mental Health Issue

Summary: this study aims to evaluate the mental health impact of the covid-19 pandemic on international migrant workers by (1) documenting mental health symptoms among migrant workers and (2) identifying risk and protective factors during the pandemic.

worldwide, there are an estimated 164 million migrant workers. although studies have documented how migrant workers have an increased risk of adverse mental health outcomes, little is known about their mental health burden during a large-scale health crisis. in the current covid-19 outbreak, migrant workers represent 9 in 10 of the covid-19 cases in singapore, with 25 dormitories gazetted to contain the spread of the virus. correspondingly, these measures have placed a spotlight on the mental well-being of migrant workers. in this research protocol, the investigators propose to administer a survey to understand the prevalence and predictors of mental health symptoms amongst migrant workers in singapore. in particular, prior meta-analyses have identified covid-19 health concerns, quarantine status, financial instability, exposure to news and misinformation and demographics (i.e., gender, age, education) as risk factors for poor mental health amongst the general population. by assessing these factors amongst the migrant worker population and documenting their impact on migrant workers' mental health, we hope to identify workers in greatest need of support during the ongoing pandemic and provide empirical evidence to guide public health policies.

Eligibility criteria:
inclusion criteria: * ≥21 years of age * hold a government-issued work permit identifying employment status
increasing physical contact between prenatally anxious/depressed mothers and their infants to improve maternal sensitivity.

Conditions: Prenatal Anxiety; Prenatal Depression; Maternal Sensitivity

Summary: the goal of this randomized controlled pilot trial is to evaluate the feasibility, acceptability, and clinical utility of a baby carrier intervention aimed at improving maternal sensitivity and mother-infant bonding in prenatally anxious/depressed mothers. the study has three main questions: 1. is the intervention feasible (e.g., enrollment and recruitment rates) and acceptable to participants (e.g., compliance and perceived benefits)? 2. does the intervention improve maternal sensitivity compared to a waitlist control group? 3. does the intervention increase mother-infant neural synchrony compared to a waitlist control group, measured using functional near-infrared spectroscopy? participants will a. choose between two soft ergonomic baby carriers and be expected to use the baby carrier for the prescribed amount of time (intervention group). b. have two home visits, one at the start (at postpartum week 8) and another one at the end of the study (at postpartum week 16). c. complete questionnaires about depression and anxiety symptoms, mother-infant bonding, and rate protocol burden. d. share their feelings and lived experiences about the frequent use of a baby carrier and increased physical contact with their baby through open-ended interview questions (intervention group).

the intervention involves mothers in the experimental group using a soft ergonomic baby carrier for a prescribed amount of time over a period of six weeks. weekly adherence self-reports will be collected via redcap. participants will be recruited from the perinatal multisite databank (pmd), an ongoing clinical cohort of individuals receiving psychiatric services during pregnancy and the first six months postpartum in the province of quebec, canada.

Eligibility criteria:
inclusion criteria: * 18 years or older * be able to communicate in english or french * diagnosed with a depressive or anxiety disorder (or both) during their intake visit within the perinatal multisite databank (pmd) * residing in the greater montreal area * have given birth to a healthy baby exclusion criteria: * having known alcohol or substance use issues, * having been diagnosed with psychosis or schizophrenia during the pmd intake assessment, or have had thoughts of harming the self or the baby * having physical restrictions that may prevent the regular use of a baby carrier * taking any medications regularly that cause potential participants to feel drowsy or dizzy * already using a baby carrier with their current baby for more than 5 hours a week

Keywords: baby carrier maternal sensitivity inter-personal neural synchrony perinatal anxiety perinatal depression
postcesarean section pain: possible demographic and medical predictors

Conditions: Pain; Cesarean Section

Summary: the aim of this retrospective study is to find out if one or more of the following parameters has an impact on postcesarean section pain:age,ethnic origin, parity,body habitus, smoking, breastfeeding, education,newborn in intensive care unit, primary/repeated operation,elective/emergency operation,junior/senior surgeon,type of anesthesia during operation.

the medical records of 600 consecutive women with a cesarean section will be reviewed.we will analyse the correlations between postcesarean section pain levels,analgesic consumption and; age,ethnic origin, parity,body habitus, smoking, breastfeeding, education,newborn in intensive care unit, primary/repeated operation,elective/emergency operation,junior/senior surgeon,type of anesthesia during operation.

Eligibility criteria:
inclusion criteria: * women undergoing a cesarean section exclusion criteria: * medical or psychological conditions not enabling reliable patients pain assessment

Keywords: analgesia
comparison of home-based video, paper/print checklist and professional home assessment in detection of fall hazards at home

Conditions: Identification of Home Fall Hazards

Summary: the purpose of this study is to assess the feasibility and potential impact of video analysis of footage taken with a gopro camera video in comparison to a homeowner checklist or gold standard home assessment as a means of detecting home fall hazards. investigators hypothesize that the assessment of homes for fall hazards with a gopro camera will be better than a homeowner paper checklist in hazard identification.

80 community-dwelling adults (50-75 years of age) will be recruited from clinics and the community through posters and advertising (n = 40 in the healthy group; n = 40 in the distal radius fracture (drf) group (adults with 3-12 months post-drf)). participants will be randomly allocated to a homeowner paper checklist or a gopro video assessment and then cross-over to the opposite intervention. to assess accuracy, a gold standard home assessment will be completed by a trained evaluator, after the homeowner checklist and gopro video assessment. upon completion of the data collection, the evaluator will conduct their assessment (gold standard); review the findings from the gopro "playback" with the participant, and conduct a semi-structured interview on their prior awareness of fall hazards, perceptions about the different methods of detecting fall hazards in their home; and intentions to remediate identified hazards.

Eligibility criteria:
inclusion criteria: * healthy group: community-dwelling adults * drf group: adults with 3-12 months post drf * ability to read, understand and speak english exclusion criteria: * identified cognitive disorder * major loss of vision or hearing * other concurrent upper extremity injuries or neurological impairments * any unhealed fractures

Keywords: fall risks at home video technology home assessment distal radius fractures