food supplement effect on overweight or moderate obesity

Conditions: Obesity

Summary: the aim of this study is to assess the effect of a food supplement containing extracts of carrot and rose hip seeds on the weight of volunteers with overweight or moderate obesity.


Eligibility criteria:
inclusion criteria: * bmi between 25 and 35 kg / m² (limits excluded), * having a fat mass (measured by impedance balance in kg) according to the following table: men 18-29 years : ≥ 21.2 kg; men 30-49 years : ≥ 21.6 kg; men 50-65 years : ≥ 23.8 kg; women 18-29 years : ≥ 31.4 kg; women30-49 years : ≥ 31.8 kg; women 50-65 years : ≥ 33.9 kg. * willing to observe dietetic plan in accordance with dietitian evaluation, * able and willing to participate to the study by complying with the protocol procedures as evidenced by his dated and signed informed consent form, * affiliated with a social security scheme. exclusion criteria: * dyslipidemia or hyperlipidemia: * fasting total cholesterol ≥ 3.0 g / l * fasting triglycerides\> 2.5 g / l * with heterozygous familial hypercholesterolemia, * diabetes treated or not with medication, * with severe hepatic and / or renal impairment, liver enzyme level (alt and / or ast) greater than 2.5 times the upper normal limit, * tsh abnormal or not stable for at least 3 months, * history of cardiac disease (heart attack, stroke, coronary artery disease) or chronic inflammatory disease in the previous 6 months, * with cancer or having had cancer in the 3 years preceding the study, with the exception of basal cell cancers of the skin, * taking drugs known to have an impact on weight management (corticosteroids, neuroleptics, anti-hiv triple therapy, etc.) in the month preceding inclusion and / or likely to consume them during the test, * taking antibiotic therapy, anti-depressant treatment or treatment related to anxiety in the month preceding the study, * taking anti-depressant treatment or treatment related to anxiety subject in a state of depression, * weight loss treatment in the previous 6 months or having followed a specific treatment promoting weight loss, * non stable weight during the last 6 months (\>5% change in total weight), * with metal implant (to allow dexa measurement), * blood donation in the month before the start of the study and during the study, * consuming food supplements or functional foods known to have an influence on weight management in the month preceding the inclusion and / or likely to take during the test, * following or having followed a hypocaloric diet (energy intake \<1,500 kcal / day) in the month preceding inclusion and / or likely to undertake this diet during the test, * following a particular diet (vegan), * diagnosed eating disorders (bulimia, anorexia nervosa, vomiting), * intense sport exercise practice (physical activity more than 4 hours per week) or not willing to maintain their exercise practises stable during the test, * smoking more than 5 cigarettes per day, unstable cigarettes consumption, or smoking cessation during 6 months preceding the inclusion or during the test, * bariatric surgery or who has a gastroplasty ring, * consuming more than 2 (women) or 3 (men) standard drinks of alcoholic beverage daily, * consuming illicit drugs, * using topical anti-cellulite treatments, * for woman: pregnant or planned to become, breastfeeding, with non-effective contraception, * known allergy to one of the component of the supplement (carrot and rose hip), * suffering from serious illnesses such as cancer, recent myocardial infarction, serious digestive pathologies or others diseases found to be inconsistent with the conduct of the study by the investigator, * taking part in another clinical trial or being in the exclusion period of a previous clinical trial, * under legal protection (guardianship, wardship) or deprived from his rights following administrative or judicial decision, * presenting a psychological or linguistic incapability to sign the informed consent, * any other condition which in the investigator's opinion may adversely affect the subject's ability to complete the study or its measures or which may pose significant risk to the subject.