Kornimate/medical-research-clean huggingface dataset:
crucumin effects on the immune system in osteoarthritis patients

Conditions: Osteoarthritis

Summary: in this study, the effects of crucumin on cellular and humoral immune system in patients with osteoarthritis will be investigated. concentration of cxcl8, april, cx3cl1 and il-17 will be evaluated with elisa. th-1, th-17, treg and ly.b cells count will be measured by flowcytometry. microrna-720, microrna-155, microrna-16 and microrna-146a gene expression will be measured with real time pcr technique.

the purpose of this study was to evaluate the effect of the active ingredient of crucumin on the reduction of symptoms of osteoarthritis. of the 30 patients participating in this study, a blood sample will be taken at the beginning of the study, and then after three months of taking the crucumin. to evaluate the response to treatment, after each person sampling, we will analyze cell count for th-1, th-17, treg and ly.b by flowcytomtry method. also we will measure cytokines level of il-17, cxcl8, cx3cl1 and april by elisa method. finally we evaluate the gene expression of microrna-720, microrna-155, microrna-146a and microrna-16 by real time pcr technique.

Eligibility criteria:
inclusion criteria: osteoarthritis patients who have been diagnosed with a rheumatologist physician based on clinical examinations and laboratory tests exclusion criteria: affected by any other acute or chronic underlying disease

Keywords: osteoarthritis, crucumin, flowcytometry
efficacy and safety of s18986 in the treatment of mild cognitive impairment patients

Conditions: Mild Cognitive Impairment

Summary: the purpose of this study is to demonstrate a long term efficacy of s18986 versus placebo on episodic memory performance in patients with mci


Eligibility criteria:
inclusion criteria: * memory complaint * acetylcholinesterase inhibitors stopped at least 3 months before selection exclusion criteria: * dementia * parkinson's disease * vascular disorder * depression * epilepsy
toxin treatment for amyotrophic lateral sclerosis (als) related sialorrhea

Conditions: Sialorrhea; Amyotrophic Lateral Sclerosis

Summary: evaluation of the decrease of the secretion of saliva in patients with amyotrophic lateral sclerosis by a local ultrasound-guided bilateral injection of botulinum toxin type a in parotids and submandibular glands. the investigators want to demonstrate 1 month after the injection, by a multicenter french randomized double blind study, an improvement of at least 25 % of the functional embarrassment due to saliva, estimated with a visual analogue scale, a decrease of the quantity of saliva and a decrease of the embarrassment for the main caregiver.

the patient will benefit from an ultrasound guided injection of botulinum toxin a (botox®) or placebo (nacl 0.9 %) and will be followed up in consultation at 4, 12, 16 (if reinjection) and 24 weeks. he will be contacted by telephone in 2 and in 8 weeks (percentage of decrease of functional embarrassment, percentage of decrease of salivary secretion rate). he can be able to benefit in the open label phase of a botulinum toxin type a injection at the 12-week follow up if he estimates that first injection was not effective or if the efficiency of the first injection began to become blurred. after the 6 months of the study, the patient will benefit again from the usual follow-up as advised by the french consensus conference in november, 2005.

Eligibility criteria:
inclusion criteria: * age \> 18 years * obtaining of a written consent after information * diagnosis of probable or certain als according to the el escorial criteria of the world federation and neurology committee on neuromuscular diseases * patient having a follow-up in an als center * sialorrhea with vas functional embarrassment \> or equal at 50/100. * patient beneficiary of social security regime exclusion criteria: * evolving disease associated with predictable survival \< 1 month * patient having previously received an injection of botulinum toxin in the salivary glands * patient taking the other medical treatments for sialorrhea in the 7 days before the inclusion in the study (scopoderm, trihexyph'nidyle, atropine, ipatropium, amitriptyline, clomipramine, oxybutinine, diphenhydramine, beta-blockers) * patient having benefited from radiotherapy or from surgery on the salivary glands * behavioral problems, dementia or other psychiatric problems * myasthenia * known pregnancy or absence of contraception recognized as effective, breast feeding

Keywords: sialorrhea amyotrophic lateral sclerosis botulinum toxin
comb effect of 4-7-8 breathing technique and stationary cycle on pp, qol and dyspnea in post cabg patients.

Conditions: Post-cardiac Surgery

Summary: to determine the combined effects of 4-7-8 breathing technique and stationary cycle on physical performance, quality of life and dyspnea in post cabg patients.

patients who meet the inclusion criteria and will be excluded from the exclusion criteria will be recruited by convenient sampling technique and will be allocated to simple randomization process. by taking a sample of 58 patients through non-probability convenience sampling and randomly assigning them into two groups, group a and group b for 18 exercise sessions per month (four to five times in a week), out of which group a will receive 4-7-8 breathing technique and stationary cycle (n=29). group b will alone receive stationary cycle (n=29). the study will be single-blind where patients will be only blind. pre and post treatment training outcomes of physical performance will be measured through 6-minute walk test, quality of life will be measured through short-item 36 (sf-36) questionnaire 2.0 version and dyspnea will be measured through modified borg scale. the data will be analyzed through spss version 26. generalized active range of motion will be given to both groups.

Eligibility criteria:
inclusion criteria: * patients who underwent a successful cabg (no complications during surgery * and/or in the following weeks) * female and male whose age between 40 to 70 years of age * phase ii cardiac rehab patients * patients who were extubated and hemodynamically stable * patients with stable chronic heart failure. * patients had no arrhythmias * patients who had ability to read and write * patients who voluntarily participated in the study. exclusion criteria: * ventricular septal defect repair. * patients have limitation of motion that prevents them from performing physical activities such as walking for 6 minute. * patients who had undergone previous cardiac surgery. * severe renal dysfunction requiring dialysis. * altered level of consciousness. * a history of musculoskeletal problems * having an orthopedic problem that prevents the use of lower and upper extremity bikes. * cancer patients receiving radiotherapy and chemotherapy. * clinical diagnosis of uncontrolled diabetes mellitus and hypertension. * physical discomfort at any stage of the study and/or any reaction to the tests (nausea, dizziness, discomfort, feeling faint, tachycardia, excessive sweating), and if they failed to attend the scheduled sessions.

Keywords: 4-7-8 breathing technique stationary cycling post cabg physical performance quality of life dyspnea
comparing different rehabilitation exercise strategies for improving arm recovery after stroke

Conditions: Stroke

Summary: the purpose of this research study is to measure the effect of participating in extra arm exercise in addition to standard rehabilitation exercises in the acute rehabilitation unit. this study will compare two different ways to perform the extra arm exercise. the first is following a customized program of hand and arm exercises that will be developed for study participants by an experienced rehabilitation therapist. the second is moving a participants arm back and forth when they are sitting in their wheelchair by using a moveable wheelchair arm rest (boost).

for this study, the investigators hypothesize that use of movable wheelchair arm rest device during inpatient therapy will lead to significantly greater improvements in ue motor recovery than conventional treatment. the aim is to perform a randomized controlled trial of the movable wheelchair arm rest device with inpatients with subacute stroke in three different inpatient rehabilitation facilities (n=58; months 6-24). participants will be \>3 days and \ 4.25 points (the fm mcid40) between movable wheelchair arm rest device and control at three months.

Eligibility criteria:
inclusion criteria: 1. 18 to 84 years of age 2. experienced a single stroke or multiple strokes \>3 days and \< 4 weeks prior to study enrollment, and currently admitted or accepted into acute rehabilitation program for stroke. 3. ue fugl-meyer motor score \<42/66 4. absence of moderate to severe shoulder pain while using the movable wheelchair arm rest device (\<6 on the 10-point visual analog pain scale) 5. absence of severe tone at the affected ue (score \<4 on the modified ashworth spasticity scale) 6. deem to be an appropriate candidate for manual wheelchair by aru clinicians. a patient who has been able to transfer into a wheelchair while at aru (with or without assistance) and has tolerated sitting in the wheelchair for at least 30 minutes. exclusion criteria: 1. subarachnoid hemorrhage 2. presence of other neurological or psychological disorders affecting motor functions 3. moderate to severe pain in the stroke-affected upper extremity (score \> 6 on 10-point visual analog pain scale), while using the movable wheelchair arm rest device 4. severe tone at the affected upper extremity (score \> 4 on the modified ashworth spasticity scale) 5. severe aphasia (score of 2 or higher on the nih stroke scale - question 9). pi may dismiss this criterion if the participant is deemed able to follow all study instructions. 6. deficits in vision, language, attention, neglect, or other cognitive functions severe enough to interfere with safe operation of wheelchair or the movable wheelchair arm rest device. 7. currently pregnant 8. difficulty in understanding or complying with instructions given by the experimenter. 9. inability to perform the experimental task that will be studied. 10. not part of another upper extremity motor-related interventional study

Keywords: cerebral vascular accident (cva)
seroprevalence of the anti-sars-cov-2 antibodies (causing covid-19) in kidney transplant recipients in severely affected region

Conditions: COVID-19 Pandemic; Transplantation, Kidney

Summary: goal of this study is to evaluate the seroprevalence of anti-sars-cov-2 antibodies in patients after kidney transplantation who are one of the risk groups for the severe course of the infection and map the progression of the virus throughout this specific part of population, which is also important for possible future epidemics. we will evaluate the seroprevalence of anti-sars-cov-2 antibodies according to age and gender. we will compare seroprevalence in all measured antibodies types and we will also assess the development of antibodies level in positive patients.

the czech republic (central europe region) is one of the most affected countries in the world by covid 19 pandemic. by 1st of march 2021, the sars-cov-2 virus infection was proven in the czech republic in 1 247 051 thousand people, which is 11.7% of the population (11 627 per 100 000, in the usa 8743/100 000, in the uk 6300/100 000, in the germany 2879/100 000, france 5379/100 000). the rapidly increasing number of people infected in october 2020 have led to adoption of strict countrywide epidemic measures, which are still largely ongoing. during first 2 months of 2021 was still serious spread of the virus in population with increasing numbers of infected persons. the sars-cov-2 virus can be detected in the body by several ways. the presence of the virus can be directly confirmed by rt-pcr or by determination of viral antigen from a swab from the nasopharynx, throat, direct examination of sputum or aspirate from bronchoscopy, or rectum. indirect methods of virus detection include the determination of antibodies in the blood. antibodies can target several structures of the virus: spike protein (s), envelope, membrane or nucleocapsid (np). the s protein is composed of s1 and s2 subunit. the s1 subunit contains receptor-binding domain (rbd) which is necessary for interaction and entering human cells. in practice, igg, igm and iga antibodies against rbd and np are usually detected.2,3 with regard of serious development of the covid 19 epidemic situation in the czech republic, we decided to do this prevalence study. our goal is to evaluate the seroprevalence of anti-sars-cov-2 antibodies in patients after kidney transplantation which is also important for possible future epidemics.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * recipient of a transplanted kidney * planned visit to the outpatient nephrology clinic of university hospital ostrava, czech republic, between 1.5. and 30.7.2021 for enrolment * planned blood collection and available results of blood tests from planned inspections from 18.1.2021. * signed consent to the use of anonymous data for scientific purposes and publications. exclusion criteria: * disagreement with participation in the study and data analysis

Keywords: covid-19 seroepidemiologic studies kidney transplant
protection of the heart with doxycycline during coronary artery bypass grafting

Conditions: Coronary Artery Bypass Grafting; Cardiopulmonary Bypass; Reperfusion Injury

Summary: the purpose of this study is to determine whether doxycycline (periostat) at a sub-antimicrobial dose will decrease reperfusion injury after coronary artery bypass grafting (cabg) surgery with cardiopulmonary bypass (cpb).

this proposal is for a randomized, placebo-controlled, double-blinded study of the use of doxycycline in patients requiring cabg surgery. patients will be randomized 1:1 to receive either doxycycline or placebo. this study will be conducted in a blinded manner. the pharmacy will randomize patients and will have the randomization code. the code will only be broken in the case of an emergency and the event will be fully documented. in addition to standard care, patients will receive oral administration of 20 mg of doxycycline or placebo twice a day at least 2 days prior to surgery, on the day of surgery, and on postoperative days 1, 2, and 3. myocardial atrial biopsies will be taken at 2 time points during the cabg procedure: during cannulation of the right atrium and 10 minutes after cross-clamp release. tissue will be analyzed for mmp-2 and -9 activity and tni and mlc-1 levels. a swan-ganz-catheter will be placed in the pulmonary artery over 24 hours to measure hemodynamics (lvswi). a coronary sinus catheter will be placed under echocardiographic guidance prior to initiation of cpb (will be removed 20 minutes after cross-clamp release). patients will have an additional ecg on post-operative days 1 and 3. additional blood will be drawn to determine doxycycline plasma levels, mmp-2 and -9 activity, total gelatinolytic activity, and levels of troponin i and t products at the following time points: pre-induction, prior to initiation of cpb, 10 and 20 minutes following the release of the aortic cross clamp (arterial and venous) and 3, 6, 24 and 72 hours post aortic cross clamp removal (venous). each of the above samples will require 6 ml of blood for a study total of 72 ml. at the time of each blood draw we will measure and record the hematocrit value.

Eligibility criteria:
inclusion criteria: * written informed consent * aged 18 through 80 years, inclusive * scheduled for primary cabg surgery with cpb exclusion criteria: * females of childbearing potential * emergency cabg * previous sternotomy * planned simultaneous surgery (i.e. valve repair or carotid endarterectomy) * myocardial infarction within 48 hours * pre-operative atrial fibrillation * pre-operative ventricular pacing or left bundle branch block (lbbb) * known hypersensitivity to tetracycline class antibiotics * renal failure requiring dialysis

Keywords: doxycycline coronary artery bypass grafting
vr for preoperative anxiety in children

Conditions: Anxiety

Summary: all of the tools currently available for preoperative preparation of children either use a third person approach (i.e., use media whereby they watch a video or look at pictures of another child receiving an anesthetic), provide tours at some time previous to the operation date, or are shown the equipment that they will encounter during their anesthetic. no preoperative programme currently allows the child to experience the entire chain of events from leaving the preoperative preparation area (and their parents), walking to the operating area, being initially prepared for and receiving anesthesia and recovering from anesthesia, in real time and from a first person perspective. as such the investigators are carrying out this study to assess whether virtual reality preoperative preparation is effective in reducing anxiety at induction of anesthesia.

the investigators' goal in this study is to investigate the effects of virtual reality preoperative preparation on anxiety in children at induction of anesthesia. the hypothesis is that utilisation of this novel 1st person immersive preparatory method will lead to an enhanced understanding of what will happen to the child (in addition to what the environment looks and sounds like) when they have their anesthetic. the investigators believe this enhanced understanding and preparation will lead to the reduction in anxiety levels before and during the induction of anesthesia, and will also lead to a reduction in postoperative negative behaviour disorders.

Eligibility criteria:
inclusion criteria: 1. patients aged between 6 -18 2. asa physical status 1-3 3. admitted for elective surgery (day case and inpatient cases) 4. cognitively normal exclusion criteria: 1. asa physical status 4-5 2. non-english speaking 3. significant visual and auditory disorders not allowing them to use the technology 4. epilepsy 5. mobility problems that would make using the technology difficult or harmful to them (i.e., reduced movement of neck) 6. cognitive impairment 7. postoperative picu care anticipated
upper limb thrombosis associated with midline catheter

Conditions: Venous Thrombosis Deep (Limbs)

Summary: the patients admitted in hospital who had midline catheter inserted in upper limb are followed-up for the presence of complications related to catheter introductions. the symptoms and signs of upper limb thrombosis are recorded. the diagnosis is confirmed by sonography examination. in the selected group of asymptomatic patients sonography examination is done 8 to 10 days after cathether insertion in order to detect the incidence of the asymptomatic thrombosis

the patients admitted in hospital who had midline catheter inserted in upper limb are followed-up for the presence of complications related to catheter introductions. the symptoms and signs of upper limb thrombosis are recorded. the diagnosis is confirmed by sonography examination. the age, gender, principal diagnosis, the vein were midline catheter is inserted and number of vein punctures for catheter insertion are recorded. afterward the patients are treated in the ward and the possible complications are recorded. the main concern is about the incidence of upper limb thrombosis. all the complications are recorded as well as date when they has appeared. the statistical analysis is done in order to evaluate the incidence of upper limb symptomatic thrombosis, the duration since insertion to thrombosis manifestation ańad its associations with age, gender, principal diagnosis, selected vein, its size and number of punctures is analysed. in the selected group of the asymptomatic patients 8 to 10 days after midline insertion upper limb sonography is done in order to detect the presence of the asymptomatic upper limb thrombosis and the same type of analysis as for symptomatic thrombosis is undertaken.

Eligibility criteria:
inclusion criteria: * the patients admitted to university hospital suffering from disease when venous access is required for period longer than 5 days or with insufficient peripheral venous access exclusion criteria: the patients who need another type of venous access, e.g. central venous access

Keywords: upper limb thrombosis, midline catheter
influence of the endoscopists and endoscopic retrograde cholangiopanceratography

Conditions: Biliary Disease; Pancreatic Diseases

Summary: retrospective analysis on a prospective database that analyzes the influence of the number of endoscopists on the endoscopic retrograde cholangiopanceratography result.

the number of endoscopic retrograde cholangiopanceratographys (ercp) performed annually by an endoscopist has been shown to influence the outcomes of the procedure, especially on the papillary cannulation rate and the adverse effects rate. the number of ercps performed annually by each endoscopist is directly related to the number of endoscopists who perform this procedure, since the total number of ercps performed annually at each center is usually constant. the hypothesis of this study is that the number of endoscopists who perform ercp in a hospital influences the results of the procedure, so that the fewer the number of endoscopists the better the results. to evaluate this hypothesis, the investigators have designed a retrospective study analyzing data from a prospectively filled database, which includes all ercps performed in our center from september 2013 to june 2020. for organizative reasons unrelated to the endoscopy unit, in the center it has beed progressively reduced the number of endoscopists who perform ercp, starting from 5 endoscopists at the beginning of the study to 3 endoscopists at the end of the study inclusion period. in fact, three different periods of similar duration can be distinguished: september 2013 to august 2015 (5 endoscopists), september 2015 to december 2017 (4 endoscopists) and january 2018 to june 2020 (3 endoscopists). the outcomes obtained with ercp in these three periods will be analyzed and compared, assessing the cannulation rate and the adverse effects rate as the main comparison parameters.

Eligibility criteria:
inclusion criteria: * patients undergoing ercp with written informed consent given * staff allocated in the endoscopy unit exclusion criteria: * rejection to participate in the study * ercp procedures performed by fellows in training

Keywords: ercp endoscopy gastrointestinal choledocholithiasis endoscopic retrograde cholangiopanceratography