effect of remote local peripheral nerve cooling on pain of arterial puncture

Conditions: Acute Pain

Summary: in this project, volunteers will be recruited to cool the superficial skin of the axillary brachial plexus away from the puncture point, resulting in local peripheral nerve cooling, and observe its impact on the pain of arterial puncture.to explore the local peripheral nerve cooling treatment can produce controllable and reversible analgesic effect even if away from the wound, and provide a new nonpharmaceutical analgesic mode for clinical.

arterial puncture is a common cause of iatrogenic pain and anxiety, which can lead to stress and arterial spasm, leading to puncture failure.clinicians usually use pharmacology to treat acute pain, but it is often accompanied by circulatory and respiratory depression, abnormal coagulation function, edema, pruritus, nausea, vomiting, constipation, addiction, etc., which can lead to death, and doctors strictly restrict the use of indications.in addition to drugs, electrical, light, mechanical or thermal stimulation can produce local reversible blocking effect of the peripheral nerve.temperature is a simple, controllable and reversible physical factor.current studies have shown that cooling the peripheral nerve to 10-15°c for 10 minutes can relieve pain, and numbness can occur after 15 minutes.these results suggest that cooling the peripheral nerve of sensory innervation in the remote trauma area can reduce nerve conduction velocity and signal amplitude, and provide a new method for non-pharmaceutical analgesia.local peripheral nerve cooling therapy is an attractive approach to blocking nociceptive information because it is non-addictive, reversible, and allows simultaneous electrophysiological monitoring of the blocked nerve.in this project, volunteers will be recruited to cool the superficial skin of the axillary brachial plexus away from the puncture point, resulting in local peripheral nerve cooling, and observe its impact on the pain of arterial puncture.to explore the local peripheral nerve cooling treatment can produce controllable and reversible analgesic effect even if away from pain stimulation, and provide a new nonpharmaceutical analgesic mode for clinical.

Eligibility criteria:
inclusion criteria: 1. 18 \~ 65 years old; 2. asa i-ii level; 3. patients with perioperative invasive arterial blood pressure monitoring; 4. right-handed; 5. allen test was normal (palm color quickly turned red or returned to normal within 10 seconds after release of ulnar artery pressure); 6. participate voluntarily and be able to understand and sign informed consent. exclusion criteria: 1. patients with a history of musculoskeletal, vascular, neurological or psychiatric disorders; 2. patients with a history of diabetes or other systemic diseases 3. patients who used any analgesic medication within the month before and during the study; 4. patients with a history of smoking, alcohol or drug addiction; 5. paraesthesia, scar, redness, damage, rash, etc. exist in the skin of the patient in the test area; 6. patients whose surgical area overlaps with the cooling treatment or puncture area; 7. female subjects are menstruating.

Keywords: skin cooling arterial puncture analgesia