Kornimate/medical-research-clean huggingface dataset:
diagnostic value of smartphone video in epileptic seizures

Conditions: Value of Smartphone in Epilepsy

Summary: 1. accuracy of seizure diagnosis based on smartphone seizure semiology anaysis 2. assess the factors that affect the diagnostic reliability of smartphone videos

e pilepsy has a substantial global burden of disease.1 diagnosis is made clinically based on a historical recount of witnessed events and a laboratory assessment. differential diagnosis for seizures is broad. even seasoned clinicians can be misled when individuals lack medical knowledge or pertinent terminology to accurately represent witnessed seizure behavior.2video electroencephalogram (eeg) monitoring (vem) is recommended when there is diagnostic uncertainty in classifying seizure type or epilepsy syndrome.3 video eeg monitoring provides objective evidence for definitive diagnosis4 ;additionally, vem may not be practical for some patients because of relative infrequency of events geographic limitations, transportation constraints, and insurance coverage may also restrict access.2,4 while vem is the criterion standard for seizure diagnosis, web-based smartphone use has become a popular means to augment clinical practice involving seizure reporting by people with epilepsy. however, smartphone videos are not recorded in a controlled environment in which the clinicians themselves are able to define when and how each spell is to be recorded,. as such, there are issues of focus, lighting, duration, and initiation that must be considered when interpreting homemade smartphone video recordings obtained by a lay population of caregivers to evaluate people with seizures on the other hand, it has been proven that discriminating seizure's semiology is a learned skill and requires specific neurologic training 11we hypothesize that outpatient smartphone videos predictive value in patients referred for evaluation of epilepsy is variable and depends on multiple factors such as seizure semiology, and interpreting physician . on the other hand, there is no consensus on quality standards and safety recommendation of smartphone videos.

Eligibility criteria:
inclusion criteria: 1. patients were included in the study at any age 2. provided voluntary consent, completed an hp, 3. submitted an outpatient smartphone video of their primary ictal event, underwent inpatient vem, exclusion criteria: 1. patients were exclude, pregnant women 2. had an incomplete/absent hp, had no smartphone video, 3. did not undergo vem, had a confirmed history of mixed epileptic and nonepileptic events (based on prior vem), declined study participation, or did not provide informed consent
evaluating the effect of the vcd on erectile function and penile length post rrp

Conditions: Prostatic Neoplasms; Prostatectomy

Summary: the purpose of this study is to perform a randomized prospective study to evaluate whether the vacuum erection device facilitates an earlier return of erectile function post radical prostatectomy. a secondary measure will be to evaluate if the vacuum erection device can help prevent penile shortening.


Eligibility criteria:
inclusion criteria: * patients undergoing a radical prostatectomy for prostate cancer who are able to attain a partial or full erection preoperatively and are sexually active. exclusion criteria: * patients on anticoagulation therapy and those with bleeding diatheses * insufficient manual dexterity of patient or spouse * iief(international index of erectile function) at baseline \< 11, indicating severe erectile dysfunction
the effect of niacin administration on oxidative stress in patients with hypercholesterolmia, as measured by the use of a novel biomarker

Conditions: Hypercholesterolemia

Summary: 1. treatment of hypercholesterolemic patients with niacin will cause a significant decrease in oxidative stress and a decrease in the atherogenecity in blood samples of the patients. 2. a possible correlation between oxidative stress in hypercholesterolemic patients taking niacin to clinical hypercholesterolemia parameters is possible. 3. using a novel biomarker will enable a precise detection of the change in the oxidative stress in hypercholesterolemic patients.


Eligibility criteria:
inclusion criteria: * hypercholesterolemia, * age above eighteen exclusion criteria: * treatment with fibrates, * pregnant/breast feeding women
evaluation of patients with diffuse parenchymal lung diseases regarding frailty

Conditions: Diffuse Parenchymal Lung Disease; Frailty; Physical Inactivity

Summary: there are very few studies in the literature examining the frailty levels of diffuse parenchymal lung disease (dpld) patients and its effect on their functional status despite the high prevalance of frailty in patients with dpld this observational study aims to learn about the relationship between frailty and functional capacity and balance in dpld patients compared to healthy subjects.

the aim of the study is to evaluate the relationship between the level of frailty and exercise capacity, respiratory functions, diffusion capacity, balance level, postural changes, activities of daily living, peripheral muscle strength and quality of life parameters in dpld patients. the second aim is to compare diffuse parenchymal lung patients and the healthy control group in terms of these parameters.

Eligibility criteria:
inclusion criteria: * being diagnosed with diffuse parenchymal lung according to the american thoracic society/european respiratory society (ats/ers) criteria, * being between the ages of 30-65, * being literate, * being willing to participate in the research, * being clinically stable and having any accompanying comorbid conditions (such as hypertension, diabetes) under control, * not having any orthopedic, metabolic or neurological problems that may prevent evaluation of peripheral muscle strength, balance and exercise capacity. exclusion criteria: * having recently experienced syncope, * having a history of unstable cardiovascular disease, * having been hospitalized due to exacerbation in the last 3 months, * having received pulmonary rehabilitation in the last 12 months, * having a neurological disease, * being dependent and using a walking aid while performing the person's daily life activities, * having a pacemaker, * having a diagnosis of lung cancer
treatment of anal fistulas with obsidian rft®

Conditions: Anal Fistula; Minimal Invasive Surgery; Platelet-rich Fibrin Foam

Summary: the study conducted a retrospective analysis from january 2018 to december 2022 on patients who received anal fistula closure with obsidian rtf® at the department of general surgery, medical university of vienna.

anal fistulas present a significant challenge in colorectal surgery, featuring abnormal passages between the anal canal and surrounding tissues. traditional treatments, while effective, may risk damaging the anal sphincter complex and subsequent fecal incontinence. sphincter-preserving techniques like autologous compound platelet-rich fibrin foam have gained popularity, offering potential for better functional outcomes in anal fistula treatment. in this context, our retrospective study aims to evaluate the efficacy and safety of autologous compound platelet-rich fibrin foam, specifically obsidian rft®, analyzing its success in fistula closure and functional outcomes, thus contributing to the advancement of sphincter-preserving methods in anal fistula management. the study conducted a retrospective analysis from january 2018 to december 2022 on patients who received anal fistula closure with obsidian rtf® at the department of general surgery, medical university of vienna. clinical diagnosis, complemented by radiographic imaging, was employed to confirm inconclusive cases. demographic, comorbidity, fistula characteristics, and postoperative data were collected from electronic records.

Eligibility criteria:
inclusion criteria: * patients who received anal fistula closure with obsidian rtf® at the department of general surgery, medical university of vienna exclusion criteria: * unclear documentation
livertoxcicity in acute leukemia patients during chemotherapy treatment

Conditions: Liver Toxicity, Chemically-Induced

Summary: detection of hepatotoxcicity in acute leukemia and study the outcome of acute leukemia patients that suffer from hepatic toxiciyt

chemotherapy induction associated with hepatotoxicity during the induction has never been studied the study aimed to determine whether chemotherapy induction is associated with livertoxicity or not

Eligibility criteria:
inclusion criteria: * patients newly diagnosed with acute leukemia who are going to start chemotherapy treatment exclusion criteria: * patients previously diagnosed acute leukemia and started treatment or in post treatment follow up
correlating real and virtual world behavioral fluctuations in adolescence

Conditions: Attention-Deficit and Hyperactivity Disorder; Anxiety; Disruptive Mood Dysregulation Disorder; Depression; Oppositional Defiant Disorder; Conduct

Summary: the present study will explore a new approach to ongoing evaluation and monitoring of fluctuations in personality traits via commercial video games. the aim of this longitudinal study is to examine the influence of everyday life event on video games performance as a function of individual differences in gaming behavioral patterns. focusing on the ongoing performance vacillations of the patient on commercial video games will offer insights in to possibly new generation of real time assessment medium of ongoing behavior.


Eligibility criteria:
inclusion criteria: * all subjects will have normal or corrected to normal vision with no sensory/motor disturbance * an accessible computer at the house hold * previous experience in playing computer games. exclusion criteria: * drug abuse * head injury * living in a boarding school and a major psychiatric or neurological disorder.

Keywords: attention-deficit and hyperactivity disorder anxiety impulsivity computer games depression
follow-up study for participants jointstem clinical trial

Conditions: Knee Osteoarthritis

Summary: this study is a long term follow-up study to investigate the safety of autologous transplantation of adipose tissue derived mesenchymal stem cells (mscs) in patient with knee osteoarthritis.


Eligibility criteria:
inclusion criteria: * patients must consent in writing to participate in the study by signing and dating an informed consent document * patients who transplanted jointstem on phase 2b clinical trial exclusion criteria: * preparing for pregnancy or pregnant women or lactating mothers. * patients who the principal investigator considers inappropriate for the clinical tria
alcohol and tobacco consumption in patients with head and neck or lung cancer

Conditions: Head and Neck Cancer; Lung Cancer

Summary: this is an multicenter study for preventive and therapeutic strategies for patients with head and neck cancer

continuing the chronic intoxication by either tobacco or alcohol after the initial diagnosis of a first lung or head and neck cancer significantly improves the risk of experiencing a second cancer, and largely affects the long term survival. addiction intervention programs should be personalized according to the patient's profile, with the aim to develop more sustained intervention and monitoring in patients identified at higher risk of not spontaneously stopping harmful substance use. as of today, the trajectories of smoking and drinking habits and the risk factors for persisting smoking or drinking habits have been insufficiently explored among patients with a first lung or head and neck cancer. the altak study aims to depict the rate of tobacco smokers 12 months after the initial diagnosis of a first lung or head and neck cancer. the secondary objectives of the study are: * to depict the rate of alcohol users 12 months after the initial diagnosis of a h\&n cancer * to depict the rate of tobacco smokers at cancer diagnosis * to depict the rate of alcohol users at cancer diagnosis * to determine the social, motivational, psychiatric, tobacco-related, alcohol-related, and cannabis-related features associated with stopping tobacco in the year following the diagnosis of a first tarc. * to determine the social, psychiatric, tobacco-related, alcohol-related, and cannabis-related features associated with stopping alcohol drinking in the year following the diagnosis of a first h\&n cancer

Eligibility criteria:
inclusion criteria: * first head and neck or lung cancer * first support * age ≥ 18 * patient covered by health insurance * signed informed consent exclusion criteria: * prior lung or head and neck cancer * history of another cancer \<5 years, not evolutive and untreated at baseline (carcinoma of the cervix, or basal cell carcinoma of the skin properly treated are allowed). the presence of a second discovery tumor location at the same time as the lung or head and neck cancer, is not a criteria for non-inclusion * mesothelioma and oesophageal cancer * unable to undergo trail medical follow up (geographical, social and psychological reasons) * pregnant or nursing women * patient under guardianship

Keywords: head and neck cancer lung cancer tobacco use disorder alcoholism
use of sodium bicarbonate as prophylaxis for kidney damage in patients with heatstroke

Conditions: Heat Stroke; Acute Kidney Injury; Acute Kidney Injury Due to Hypovolaemia

Summary: this study protocol aims to prevent the need for renal replacement therapy in patients with rhabdomyolysis secondary to heatstroke. it is based on previous studies showing that bicarbonate infusion reduces renal failure in similar contexts. the intervention will be conducted at the general hospital of mexicali during the summer, targeting the prevention of renal failure and reducing the necessity for renal replacement therapy.

the present study protocol explores the possibility of preventing the need for renal replacement therapy in patients who develop rhabdomyolysis secondary to heatstroke. this is based on previous studies that have used bicarbonate infusion in the context of rhabdomyolysis secondary to compartment syndrome, finding a lower incidence of renal failure. due to the aforementioned, we propose to carry out a similar intervention at the general hospital of mexicali, where there is a significant incidence of heatstroke during the summer months. the aim is to determine whether this intervention is useful in preventing the development of renal failure and the requirement for renal replacement therapy.

Eligibility criteria:
inclusion criteria: * admitted to the general hospital of mexicali with the diagnosis of heat stroke. * meeting the operational definition (exposure to heat, body temperature at admission greater than 40 degrees celsius). * cpk level greater than 1000 u/l. * having informed consent from the patient or the legally responsible adult. exclusion criteria: * exclusion of the heat stroke diagnosis during their evaluation. * lack of serum creatinine levels at the time of admission to the protocol.
effect of golimumab in participants with active axial spondyloarthritis (p07642, mk-8259-006)

Conditions: Spondylitis, Ankylosing

Summary: this two-part study was to evaluate the effect of golimumab (sch 900259, mk-8259) in participants with active axial spondyloarthritis (axial spa). in part 1, participants were to receive golimumab 50 mg or matching placebo subcutaneous injections on day 1 (baseline) and at weeks 4, 8, and 12. during part 1 of the study, participants were to not know the identity of the injection. in the part 2 extension, all participants were to receive golimumab 50 mg subcutaneous injections beginning on week 16 and then every 4 weeks up to week 48. in part 2, the participants were to be told they were receiving active study drug. the primary hypothesis of this study was that treatment with golimumab 50 mg every 4 weeks is superior to placebo as measured by the proportion of participants achieving an assessment in ankylosing spondylitis (asas) 20 response at week 16.


Eligibility criteria:
inclusion criteria: * active axial spondyloarthritis with disease duration ≤5 years, and chronic back pain of ≥3 month duration * have either an inadequate response to 30 days of optimal daily doses of at least one non-steroidal anti-inflammatory drug (nsaid) or must be unable to receive a full 30 day maximal nsaid therapy because of intolerance, toxicity or contraindications to nsaids * females of child-bearing potential must use contraception * no history of untreated latent or active tuberculosis exclusion criteria: * fulfillment of modified new york criteria for ankylosing spondylitis * has ever received tumor necrosis factor (tnf)-α targeted therapy or any biological agents * any systemic inflammatory condition other than spondyloarthritis * serious infection within 2 months * any known malignancy or a history of malignancy within the previous 5 years * has or had a substance abuse (drug or alcohol) problem within the previous 2 years
transcranial doppler ultrasound and minimal hepatic encephalopathy

Conditions: Minimal Hepatic Encephalopathy

Summary: minimal hepatic encephalopathy (mhe) is a subclinical complication of liver cirrhosis with a relevant social impact. thus, there is urgent need to implement easy to use diagnostic tools for the early identification of affected patients. this study was aimed to investigate cerebral blood flow, systemic hemodynamics as well as endothelial function of cirrhotic patients with mhe, and to verify their change after treatment with rifaximin.


Eligibility criteria:
inclusion criteria: * diagnosis of liver cirrhosis on the basis of clinical, laboratory and ultrasound findings exclusion criteria: * active alcohol abuse (excessive alcohol intake stopped more than 6 months before the enrollment); * chronic pulmonary diseases; ongoing infections; cerebrovascular diseases; primary or secondary cerebral neoplasm; primary liver neoplasm; heart function failure; chronic kidney disease; peripheral vascular disease; treatment with rifaximin or systemic antibiotics in the previous 15 days; * smoking habit; * grade 1 or overt hepatic encephalopathy.
efficacy of low analgesic doses of ketamine associated with opioids in refractory cancer pain treatment

Conditions: Pain

Summary: long-term opioid therapy is commonly administered for the management of severe cancer pain. increasing doses of opioids are titrated against effects until analgesia is achieved or intolerable adverse effects occur. ketamine, an n-methyl-d-aspartate (nmda) receptor antagonist, has been reported to improve analgesia in patients with uncontrolled pain receiving high doses of opioids. this study aims at determining the effectiveness of ketamine as an adjuvant to opioids in relieving cancer pain.

main objective: to show that low analgesic doses of ketamine in intravenous infusion during 4 days associated with opioids better relieve refractory cancer pain than opioids without ketamine. this study is a prospective study, multicenter (11 centres), consisting of 3 phases: * a randomized controlled double blind phase of 5 days with 2 parallel groups of 38 patients each : ketamine (in association with high opioids), in intravenous injection during 4 days, versus placebo (in association with high opioids), in intravenous injection during 4 days ; * an open-label phase of maximum 4 days, during which the ketamine panpharma® is administered in intravenous infusion to the hospitalized patients who are still having uncontrolled pain persisting or recurrent ; * an observational phase : starting at the discharge of the patient, of a maximal period of 6 months.the inclusion period is during 18 months, the total duration of the study is 2 years. 76 patients are expected: 38 will be treated with opioids and ketamine; 38 will be treated with opioids and a placebo. success is defined by a decrease of the daily pain score of 50 % after 4 days. the expected rate of success in the placebo group is 10 % whereas the expected rate of success in the ketamine group is 30 %. primary outcome (pain score on a 11-point numerical scale) will be evaluated everyday as well as secondary outcomes (patient and clinician global impression of change, opioid consumption, adverse reactions, patient satisfaction on pain relief, sleep interference score). vital parameters (cardiac frequency, respiratory frequency and arterial blood pressure) will be checked everyday, many times a day : every hour for the four hours after the beginning of the treatment and then, every four hours ; every hour for the two hours following a dose shift).

Eligibility criteria:
inclusion criteria: * hospitalized cancer patients (informed and conscious of the cancer diagnostic) * undergoing opioid treatment for 15 days at least * refractory pain (score higher than 5 on an 10-point numerical pain rating scale) * ability to score pain on a numerical pain rating scale * patient written agreement exclusion criteria: * ketamine contraindications * methadone or other nmda-antagonist treatment * karnofsky index under 10 * pregnancy

Keywords: cancer refractory pain uncontrolled pain ketamine
prospective cohort of perioperative results

Conditions: Perioperative/Postoperative Complications

Summary: perioperative online register of the care process and outcomes. observational prospective cohort.

center are invited to join the perioperative register where they input anonymized data about the surgical process and outcome.

Eligibility criteria:
inclusion criteria: * patients undergoing surgery exclusion criteria: * none

Keywords: periopererative enhanced recovery
surgeon's performance in predicting postoperative infections

Conditions: Postoperative Infection

Summary: post-surgical (bacterial) infections are the most frequent post-surgical complications, including deep or superficial wound infections, urinary tract infections, pneumonia, and even sepsis. approximately 6.5-25% of all surgical patients will develop any type of bacterial infection. to personalize surgical infection management, (artificial intelligence) models are in the making to predict which patients are at high or low risk of developing a post-surgical infection. in order to benchmark these prediction models to the predictive capabilities of surgeons, the investigators aim to investigate the performance of surgeons in predicting the risk of a patient developing (any type) of post-surgical infection within 30 days.

a prospective non-interventional study is performed to collect surgeons' predictions on the risk of a patient developing a postoperative infection within 30 days of surgery. surgeons are asked to fill in a short questionnaire asking about the estimated infection risk. the actual outcome (infection \< 30 days of surgery) of a patient will be collected retrospectively after completion of the study. this study will have no effect on standard care: surgical interventions and postoperative care will be carried out according to standard clinical practice. besides a one-time estimate of the surgeon, immediately after the surgical procedure, no other interventions will be performed and surgical specialists will carry out their normal post-surgical care, including screening and treating (if necessary) their patients for postoperative infections.

Eligibility criteria:
predictions are made for patients with the following inclusion and exclusion criteria: inclusion criteria: * adult patients (\>18 years old) * acute or elective surgery * invasive or minimally invasive surgical procedures exclusion criteria: * outpatient procedures or procedures not requiring any form of monitoring/anesthesia * procedures for which the primary indication is (treatment for) an infection * radiological procedures * cardiological catheterization procedures * psychiatric treatment under anaesthesia (i.e. electroconvulsive therapy) * sole anaesthetic procedures except for implantation of a neurostimulator * brachytherapy procedures * endoscopic procedures for diagnostic purposes only * procedures that only entail the taking of a biopsy for diagnostic purposes * patients that are pregnant * procedures out of office hours (before 8.00 am or after 5.00 pm)