Kornimate/medical-research-clean huggingface dataset:
clinical and radiological outcomes of the romax hip resurfacing system

Conditions: Arthritis (Hip); Hip Dysplasia, Congenital

Summary: the goal of this observational study is to collect clinical and radiological data to monitor the safety and performance of the romax hip resurfacing system. the main parameter that will be measured is the rate of revisions at 10 years.

this single-center, post-market, prospective, longitudinal, and uncontrolled cohort study aims to evaluate the survival rate of the medacta romax hip resurfacing system, particularly focusing on dislocations and the potential consequences of wear over a 10-year period. additionally, the study will assess clinical performance through patient-reported outcomes (proms) and analyze the migration behavior of the device using the ctma method in a subgroup of 40 patients. the study will include a total of 150 cases, with 40 patients undergoing ctma analysis at 3 years post-surgery. eligible patients will be informed during preoperative visits and included upon signing the consent form, prior to surgery. participation in the ctma subgroup is optional and does not affect overall study inclusion. follow-ups will be conducted at 3 months, 1, 3, 5, and 10 years. data collection will include clinical scores, clinical and radiological data related to preoperative and postoperative status, and perioperative surgical details.

Eligibility criteria:
inclusion criteria: * patients eligible for hip resurfacing, suitable for the implantation of a medacta romax hip resurfacing system according to the manufacturer's defined indication for use. * aged between 18 and 65 years at the time of surgery. * ability and willingness to provide written informed consent for participation. exclusion criteria: * active infection * bmi \> 40 * mental illness, when the known pathology is likely to compromise the patient's ability to consent, affect the patient's assessment of their progress, or complete follow-up appointments and exams. * significantly deformed anatomy (at the surgeon's discretion) * osteomalacia where the fixation of an uncemented implant is contraindicated * active rheumatoid arthritis * osteoporosis * metabolic disorders likely to impair bone formation and for which the fixation of an uncemented implant is contraindicated * muscle atrophy or neuromuscular disease * known allergy or hypersensitivity to the implant material * any patient who cannot or does not wish to give informed consent to participate in the study * patients whose chances of regaining independent mobility would be compromised by known concomitant medical issues.

Keywords: resurfacing
phase i trial of docetaxel and low-dose fractionated radiation in the treatment of metastatic or recurrent nsclc

Conditions: Non-Small Cell Lung Cancer

Summary: the purpose of this study is to assess the maximum tolerated dose of low-dose radiation in combination with docetaxel in recurrent or metastatic non-small cell lung cancer for second-line therapy.


Eligibility criteria:
inclusion criteria: * patients must be 18 years of age or greater. * histologically or cytologically proven non-small cell lung cancer that is either metastatic or recurrent and failed at least one prior platinum-based chemotherapeutic regimen. * patients who have recurred after previous surgery and/or radiation may participate in this trial. * patients may have had prior neoadjuvant or adjuvant therapy. * patients with known brain metastases are eligible for this clinical trial if their disease has been treated and they are clinically stable and documented by a stable or improved pretreatment ct or mri scan of the brain to evaluate for cns disease within 28 days prior to registration. * measurable or non-measurable disease documented by ct, mri, x-ray or nuclear exam (fdg-pet). measurable or non-measurable disease must be present outside the area of surgical resection. pleural effusions, ascites and laboratory parameters are not acceptable as the only evidence of disease. * progression after at least one prior platinum-based chemotherapy. * greater than 3 weeks since surgery and must have recovered from all associated toxicities at time of registration. * anc ≥ 1,500/µl and platelet count ≥ 100,000/µl obtained within 28 days prior to registration. * adequate hepatic function documented by a serum bilirubin ≤ 1.5 times institutional upper limit of normal and liver enzymes (sgot or sgpt) ≤ 2.5 x the institutional upper limit of normal obtained within 28 days prior to registration. * patients requiring lung radiation must have an fev1 of \> 1000 liters obtained within 28 days prior to registration and must have pulmonary function tests with dlco. * zubrod performance status of 0,1 or 2. exclusion criteria: * no prior single-agent, weekly docetaxel chemotherapy. * peripheral neuropathy ≥ grade 1. * prior malignancy except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage i or ii cancer from which the patient is currently in complete remission or other cancer from which the patient has been disease-free for 5 years. * pregnant or nursing women.

Keywords: nsclc non-small cell lung cancer non-small cell lung cancer docetaxel radiation metastatic recurrent
the role of transdermal co2 in mda level in patient underwent abdominal aortic temporary cross clamp

Conditions: Placenta Accreta

Summary: the role of transdermal carbon dioxide in malondialdehyde level as predictor of ischemia reperfusion injury in patients underwent abdominal aortic temporary cross clamp

abdominal aortic temporary cross clamping procedures in patients with placenta accreta undergoing hysterectomy have been performed at dr. soetomo hospital surabaya for a period of 4 years. in the aortic cross-clamping procedure, an ischemic condition occurs, after the cross-clamp is released the distal tissue from the occlusion which was initially in an ischemic state gets blood flow suddenly (reperfusion) causing ischemia reperfusion injury. this study aims to determine the effect of transdermal administration of carbon dioxide (co2) as a protective factor for ischemia reperfusion injury in patients undergoing abdominal aorta temporary cross clamp. the design of this study is experimental in patients who underwent abdominal aorta temporary cross clamp. subjects were divided into two groups. the first group was treated with co2 transdermal administration and the second group was the control group.

Eligibility criteria:
inclusion criteria: * patients with placenta accreta diagnosed with placental accreta index (pai) based on the results of ultrasound and underwent abdominal aorta clamping surgery (control of bleeding in accreta) exclusion criteria: * patients with severe comorbid disorders based on previous clinical examination: chronic kidney disease, heart disease * patients with septic shock and sepsis * patients with peripheral artery disease

Keywords: abdominal aortic cross clamp
the use of guide wire in biliary cannulation: angled or straight tipped guide wire?

Conditions: Deep Biliary Cannulation

Summary: the purpose of the study is to prospectively evaluate the deep biliary cannulation in ercp with the angled tipped guide wire or the straight tipped guide wire.

patients coming to ercp examination are being divided randomly to two different groups. the deep biliary cannulation is started with predetermined guide wire. if the cannulation does not succeed in two minutes, the procedure is continued as normal.

Eligibility criteria:
inclusion criteria: * the need for ercp assessed by a specialist in gastrointestinal surgery exclusion criteria: * prior sphincterotomy * age under 18 * age over 90 * contrast media allergy * inability to give informed consent

Keywords: ercp deep biliary cannulation guide wire cannulation post-ercp pancreatitis success of deep biliary cannulation rate of post-ercp pancreatitis time used to deep biliary cannulation
determine the frequency of a htppe in 5 years (± on 1 year) after a first episode of idiopathic pulmonary embolism.

Conditions: HTPPE; Idiopathic Pulmonary Embolism

Summary: forward-looking troop established(constituted) by the patients having been included in the study " padis ep ", phrc on 2006 and 2009, randomized checked(controlled), double-blind, comparing an anticoagulating treatment(processing) extended by coumadine versus placebo during 18 months at patients having had a first episode of ep idiopathique treated(handled) initially 6 months by anti-vitamin k.


Eligibility criteria:
inclusion criteria: * patients having ended the study padis ep after the visit of the end of study and having signed the consent htp. exclusion criteria: * refusal to grant in writing to participate in the study padis htp

Keywords: httpe idiopathic pulmonary embolism
mechanisms of infertility and hormonal changes in patients with chronic kidney disease

Conditions: Infertility

Summary: patients with chronic kidney disease (both men and women), especially those with terminal renal failure, manifest infertility. there has been demonstrated several hormonal changes in patients on dialysis. increased levels of luteinizing hormone (lh) has been seen in men (12). in women the opposite has been reported. the number of spermatocytes is reduced and a disturbance in maturation has been observed. this project is aimed to study the influence of uremic milieu on fertility in men and women. the hypopituitary/hypothalamus gland axis and hormonal levels will be studied.

renal elimination of hormones and peptides. by using a human transplantation model the investigators will study changes in hormonal levels before and after a successful transplantation up to 12 months. hormones: testosterone, shbg (sex hormone binding globulin), lh (luteinizing hormone), fsh (follicle stimulating hormone), estradiol and inhibin b. analysis of sperm quality, concentration, motility, morphology and as well dna-fragmentation index (dfi) in men with chronic kidney disease. in women the investigators will study the maturation of follicles via vaginal ultrasound. controls are persons from a study at dept of reproductive medicine.

Eligibility criteria:
inclusion criteria: * gfr-levels exclusion criteria: * \> 50 years old

Keywords: hormone sperm chronic kidney disease
gao narasd lithium study

Conditions: Bipolar Disorder

Summary: this study is a 4-month open-label study of lithium in the acute treatment of patients with bipolar i or ii disorder. eligible patients will receive lithium 300 mg twice daily and titrated in 300 mg increments every 7 days as tolerated to levels \> 0.6 meq/l. blood samples are collected at baseline and at the end of study. analyses of 45 molecule expressions in mononuclear blood cells at baseline and endpoint will be carried out after the completion of study. fifty patients meeting diagnostic and statistical manual of mental disorders-5 (dsm-5) criteria for bipolar i or ii will be enrolled.


Eligibility criteria:
inclusion criteria: for inclusion in this study, subjects must meet all of the following criteria: 1. able to provide informed consent before beginning any study-specific procedures; 2. male or female, 18-70 years old; 3. meets current dsm-5 criteria for bipolar i or ii disorder as assessed by the the m.i.n.i. international neuropsychiatric interview (mini); 4. any symptomatic phase of bipolar i or ii disorder including, depressive, manic, mixed or hypomanic 5. global clinical impression-severity for bipolar disorder (cgi-s-bd) ≥3; 6. willing to take lithium; 7. if a sexually active female of childbearing potential, be using a reliable method of contraception; 8. women with reproductive potential must have a negative urine pregnancy test; 9. willing to have blood drawn: exclusion criteria: any of the following is regarded as a criterion for exclusion from the study: 1. unwilling to comply with study requirements; 2. renal impairment (serum creatinine \>1.5 mg/dl); 3. thyroid stimulating hormone (tsh) over \>20% above the upper normal limit (participants maintained on thyroid medication must be euthyroid for at least 3 months before visit 1; 4. other contraindication to lithium, 5. patients who have had severe adverse reaction to lithium; 6. patients who require inpatient care; 7. drug/alcohol dependence requiring immediate acute detoxification; 8. pregnancy as determined by serum pregnancy test or breastfeeding; 9. history of nonresponse to lithium at doses ≥ 900 mg/d for ≥ 8 weeks; 10. unwilling to have blood drawn 11. patients with chronic medical conditions such as diabetes, coronary artery disease, immune diseases, infectious diseases and neurological disorders; 12. active suicidal ideation with a plan or intent, a suicide attempt within past 6 months or more than 2 suicide attempts within the past 2 years. 13. currently on lithium
cross-sectional survey on the use of tobacco products - italy

Conditions: Tobacco Use

Summary: the main purpose of the research study is to estimate the prevalence of tobacco product use and describe the tobacco use patterns in adults in italy.

the aim of the survey is to describe the current and past patterns of use of tobacco products in the general adult population of italy and in adult iqos users registered in the iqos user database of philip morris italia s.r.l. (italy iqos user database), and explore their association with key independent variables. more specifically, the objectives are: 1. estimate the prevalence of current tobacco use status in the study population. 2. describe the past tobacco use status (cigarette, iqos and other innovative products, including e-cigarettes) in the study population (i.e. never-use, initiation, product use transition, cessation, re-initiation, and relapse). 3. explore the association between self-reported health status and use of tobacco products in the study population. 4. explore the association between patterns of use (including misuse) with motivation to use, perceived quality attributes of iqos (e.g. risk and self-reported changes since switching to the product, in a number of relevant domains where iqos may have potential benefits), and consumer's satisfaction in the population of iqos users in italy registered in the italy iqos user database.

Eligibility criteria:
inclusion criteria (all participants, including iqos users): * legally permitted to buy tobacco products in italy (≥18 years of age). * currently residing in italy. * able to read, write and understand italian. * consent to participate in the survey inclusion criteria (iqos users only): * has used more than 100 heets tobacco sticks in his or her lifetime. * is currently using iqos. * has access to the internet. * is not currently employed by philip morris international or any of its affiliates exclusion criteria: * not meeting the inclusion criteria.

Keywords: tobacco use iqos
hybrid closed loop insulin pump and bariatric surgery in patients with type 1 diabetes

Conditions: Bariatric Surgery; Type 1 Diabetes

Summary: bariatric surgery is increasingly performed on patients with type 1 diabetes. it exposes these patients to an increased risk of hypoglycemia, including severe hypoglycemia, and of severe episodes of hyperglycemia, beyond the perioperative period. the long-term efficacy and safety of hybrid closed-loop insulin pump in these patients has not yet been published.

patients with type 1 diabetes and obesity are at risk of "double diabetes". bariatric surgery may be indicated for these patients, to combat insulin resistance. nevertheless, post-operative patients are at risk of hypoglycemia. at the same time, patients with type 1 diabetes can benefit from a hybrid closed loop insulin pump to improve diabetes control and reduce the occurrence of hypoglycemia. in type 1 diabetic patients who have undergone bariatric surgery and are treated with a hybrid closed loop insulin pump, continuous glucose measurement can be studied. in the medium and long term, the efficacy and safety of this system in this context will be described.

Eligibility criteria:
inclusion criteria: * major patient * with type 1 diabetes for \> 1 year * obese (bmi≥30) * having undergone bariatric surgery * on a hybrid closed-loop insulin pump * not pregnant * no hybrid closed-loop insulin pump discontinuation for more than 45 days after surgery exclusion criteria: - patient informed and opposed to data use

Keywords: bariatric surgery type 1 diabetes hybrid closed-loop insulin pump
quality of life (qol) in female patient with schizophrenia

Conditions: Schizophrenia

Summary: the primary objective of this study is to demonstrate clinical and statistical superiority of quetiapine compared to risperidone in korean version of heinrich's quality of life scale after 8 weeks trial of drugs.

prolactin related adverse events are closely related to patient's perception on their illness and quality of life . poor subjective wellbeing induced by prolactin elevation after antipsychotic drug treatment can complicate the clinical outcomes of treatment.quetiapine has negligible effects on the elevation of prolactin and does not produce hyperprolactinemia related adverse events such as amenorrhea, galactorrhea that may disturb quality of life in famel patient. in this randomized, open label, 8-week study, the impact of quetiapine and risperidone on quality of life in female patients with schizophrenia will be compared.

Eligibility criteria:
inclusion criteria: 1. diagnosis: schizophrenia (dsm-iv) 2. female, age: between 18-60 years 3. who either need first time treatment with antipsychotic drug or recently 4. sign written informed consent exclusion criteria: 1. taking other psychiatric medications during last 30 days 2. refractory schizophrenia 3. a current medical illness associated with sexual dysfunction 4. previous history of no response to quetiapine or risperidone treatment 5. previous enrolment or randomisation of treatment in the present study. 6. participation in a clinical study during the last 90 days. 7. pregnancy 8. alcohol or substance abuser

Keywords: quality of life schizophrenia quetiapine risperidone
dysphagia rehabilitation for nasopharyngeal carcinoma patients post radiotherapy

Conditions: Nasopharyngeal Carcinoma; Radiotherapy

Summary: in hong kong, every 30 and 12.9 in 100,000 males and females respectively has nasopharyngeal carcinoma (npc). with early detection and advances in medical care, the number of npc survivors post radiotherapy is rapidly growing in hong kong. one of the most distressing consequences post radiotherapy for npc patients is swallowing disorder, or dysphagia. dysphagia in npc patients almost certainly cause frequent chest infection, dehydration, malnutrition and limitations to concurrent treatment such as oral medication. given the existing large costs npc patients incur to the healthcare system, dysphagia only serves to further inflate the soaring costs. in an attempt to reduce dysphagia related costs to the healthcare system, swallowing rehabilitation is offered to npc patients. currently, two major swallowing rehabilitation approaches are commonly adopted. the first is traditional rehabilitation, which involves patients performing various oropharyngeal exercises aimed at improving swallowing physiology. the other swallowing rehabilitation approach is transcutaneous electrical stimulation, which entails using small amount of electric current to increase muscle strength while patients are engaged in swallowing activities. these two methods are proven as effective in patients with stroke and head and neck carcinoma patients. neither of these methods, nevertheless, yields any efficacy studies in treating npc patients. yet, clinicians continue to use either one or both rehabilitation methods as swallowing rehabilitation. this study aims to address the gap in efficacy studies on swallowing rehabilitation for npc patients post radiotherapy. the research results should provide justification for rehabilitation time, clinicians' efforts, costs involved and resources used in rehabilitating the swallowing difficulties of the npc patients.


Eligibility criteria:
inclusion criteria: * able 18 years of age * undergone primary radiotherapy or chemoradiotherapy as the treatment * are expected to complete the 12 month follow-up exclusion criteria: * prior history of head and neck surgery except biopsies of the np or the neck nodes * previous history or having a concurrent neoplasm other than npc * other severe medical problems that might contribute to dysphagia, e.g. cerebral vascular accident, neuromuscular diseases, respiratory diseases that may cause dysphagia * present contraindications for the use of electrical stimulation which include pregnancy, pacemaker, other implanted electrodes or significant reflux * non-oral feeding is contemplated in prior to treatment * inability to complete the assessment including cognitive impairment * of a low life expectancy related to npc or other illnesses * history of dysphagia prior to radiotherapy or chemoradiotherapy
percutaneous internal ring suturing versus conventional laparoscopic repair of congenital inguinal hernia

Conditions: Pediatrics; Inguinal Hernia Repair

Summary: background:comparison between percutaneous internal ring suturing vs conventional laparoscopic repair of congenital inguinal hernia in male patients. methods : this is a prospective randomized study including 109 male patients with 120 cihs patients were randomly categorized into two groups. group a were subjected to laparoscopic disconnection of the hernia sac and narrowing of the internal ring (ir). group b underwent pirs. the intended primary outcome was recurrence within 1 year, besides comparing the two techniques regarding operative time, efficacy, safety, cosmetic outcome, and postoperative complications.

introduction since the 1990s laparoscopy has gained popularity in the management of congenital inguinal hernia (cih). several laparoscopic techniques have been described, including laparoscopic disconnection of the hernial sac with narrowing of the internal ring (iir) which was described to mimic the open technique, and the extraperitoneal approach involves using various types of needles under laparoscopic guidance to percutaneously secure a suture circumferentially around the internal ring, thus obliterating the sac opening. this study compared the short-term outcome of percutaneous internal ring suturing (pirs) versus laparoscopic disconnection of the hernial sac with narrowing of the internal ring in children. materials and methods: this study included 109 male patients with 120 cihs during the period from may 2022 to may 2024. patients were randomly categorized into two groups. group a were subjected to laparoscopic disconnection of the hernia sac and narrowing of the internal ring (ir). group b underwent pirs. the intended primary outcome was recurrence within 1 year, besides comparing the two techniques regarding operative time, efficacy, safety, cosmetic outcome, and postoperative complications.

Eligibility criteria:
inclusion criteria: * male patients * age of 6 month to 5years * reduciable congenital inguinal hernia either unilateral or bilateral. exclusion criteria: * incarcerated cih * recurrent cih * patients with undescended testis, * patients with hydrocele, * patients with chronic comorbidity such as congenital heart disease and severe chest troubles

Keywords: laparoscopy inguinal hernia pirs sac disconnection narrowing of the internal ring