Kornimate/medical-research-clean huggingface dataset:
peripartum mental health cohort study in guangzhou

Conditions: Depression; Anxiety

Summary: the purpose of this study is to determine the incidence,development trajectory and risk factors of the main peripartum mental health problems as well as explore its adverse outcomes.

peripartum mental health problems (such as anxiety and depression), affecting more than 20% of mothers, is one of the most common complications around childbirth and gradually have become global public health issues. however, little is known about the course of peripartum mental health problems and possible fluctuations, as well as related risk factors among chinese women. in addition, there are no effective prediction and preventive strategies for postpartum depression. the peripartum mental health cohort study in guangzhou will collect the epidemiological, clinical information and biological specimens across pregnancy and childbirth to establish trajectory of peripartum mental health and identify the factors influencing the fluctuations and build a comprehensive prediction model of postpartum depression, as well as explore its adverse outcomes. this study would help to determine the timing of screening and target interventions to improve women's and their offspring's health.

Eligibility criteria:
inclusion criteria: 1. pregnant women with \<20 weeks of gestation 2. pregnant women intended to eventually deliver in guangzhou women and children's medical center 3. permanent residents or families intended to remain in guangzhou with their child for more than 3 years exclusion criteria: 1. combined with heart disease, hypertension, diabetes or hyperthyroidism 2. taking anti-depressants and other treatments for depression 3. participants was in infection status when the biological samples were collected

Keywords: peripartum mental health risk factors pregnancy outcome cohort
the effects of an anti-inflammatory diet with or without curcumin supplementation on anthropometric measurements, concentrations of thyroid hormones, anti-tpo, and systemic inflammation in plasma and nfk-b in peripheral blood mononuclear cells in patients with hashimato

Conditions: Thyroid Diseases; Hypothyroidism; Hashimoto Disease

Summary: the goal of this clinical trial is to investigate the effects of an anti-inflammatory diet with or without curcumin supplementation on anthropometric measurements, concentrations of thyroid hormones, anti-tpo, and systemic inflammation in plasma and nfk-b in peripheral blood mononuclear cells in patients with hashimoto. the main questions it aims to answer are: 1. does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the changes in anthropometric measurements (weight, body mass index, bmi, waist circumference, waist-to-hip ratio) in patients with hashimoto's disease? 2. does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the changes in the serum concentration of thyroid hormones (t3, t4, tsh) in patients with hashimoto's disease? 3. does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the change of anti-tpo concentration in patients with hashimoto's disease? 4. does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the changes in systemic inflammation indicators (hs-crp, il-6) in plasma and nf-κb in peripheral blood mononuclear cells in patients with hashimoto's disease?


Eligibility criteria:
inclusion criteria: having hashimoto's thyroiditis willingness to cooperate body mass index between 35 and 18.5 tsh less than ten and without clinical symptoms not taking levothyroxine tablets exclusion criteria: pregnancy and breastfeeding kidney diseases follow non-routine weight loss diets for three months before the start of the study × taking slimming and fat-burning drugs, fiber powder mineral, vegetable, and fiber vitamin supplements

Keywords: thyroid diseases hypothyroidism hashimoto disease anti-inflammatory diet curcumin
pass mis® post-market clinical follow-up

Conditions: Spinal Fractures

Summary: prospective, multicenter non comparative and observational study (post-market clinical follow-up).

patients operated with pass mis® manufactured by medicrea® international between july 2016 and july 2017. the inclusion period will be 12 months and the follow-up 24 months

Eligibility criteria:
inclusion criteria: * patient which need to be operated to treat a fracture at the lumbar and/or thoracic spine with the pass mis® device from medicrea® * patient \> 18years * patient with a mature skeleton * patient able to understand the protocol and the planning visit * patient able to complete a self-administered questionnaire * patient who have signed the informed consent form exclusion criteria: * patient presenting other medical indication than thoracolumbar fracture * patient unable or who refuse to sign an informed consent form * patient unable to complete a self-administered questionnaire * patient judged as non-compliant by the investigator or not able to come back for follow-up visits * patient who need to receive or who received an open procedure * patient who has been not implanted with the pass mis® system * pregnant women or intending to get pregnant within the next 2 years after the surgery * patient with contra-indications to do radiographies * local infectious state * allergy or intolerance to the materials, suspected or known * any contra-indications present in the notice of the product
serum proteomics analysis for sepsis

Conditions: SIRS; Sepsis; Severe Sepsis; Death

Summary: serum proteomics is a very useful tool to identify various disease. the purpose of the present study was to find differential proteins among patient with normal, sirs, sepsis, severe sepsis, death and to screen potential biomarkers for their dynamic changes. serum proteins were identified by itraq labeling and lc-ms/ms. the bioinformatics analysis was performed with the mascot software and the international protein index (ipi) and the gene ontology (go) database and kegg pathway database. the differentially expressed proteins were verified by western blot by another sample collected from clinical.


Eligibility criteria:
inclusion criteria: * male and female aged 18 years old and over; * clinically confirmed infection; * fulfilled at least two criteria of systemic inflammatory response syndrome * (a) core temperature higher than 38 °c or lower than 36 °c * (b)respiratory rate above 20/min, or pco2 below 32 mmhg * (c) pulse rate above 90/min, and * (d) white blood cell count greater than 12,000/μl or lower than \< 4,000/μl or less than 10% of bands. exclusion criteria: * younger than 18 years of age; * acquired immunodeficiency syndrome; * reduced polymorphonuclear granulocyte counts (\< 500 μl-1); * died within 24h after admission into the icu, or refused to participate in the study, or declined treatment during the period of observation.

Keywords: proteomics, serum, sepsis, potential biomarkers, dynamic changes normal
mother-infant bonding in the brain: a mindfulness-based intervention

Conditions: Postpartum Depression; Postpartum Anxiety; Parental Stress

Summary: the study investigates the effectiveness of the mindfulness-based intervention "mindful with your baby" in women with babies between 5-9 months postpartum who experience heightened levels of postpartum depression, anxiety and/or parental stress. the intervention "mindful with your baby" is one of the very few interventions for maternal postnatal mental health issues that takes the bond between mother and infant into account. it is hypothesized that the "mindful with your baby" intervention will reduce levels of postpartum depression, anxiety and parental stress, and improve mother-infant behavioral interaction and increase neural synchrony between mother and infant brains.


Eligibility criteria:
inclusion criteria: * pregnant women (18+y). * first antenatal visit \< 12 weeks. * score above cut off on the edinburgh postnatal depression scale (epds), the anxiety subscale of the symptom checklist (scl-90) and/or the parental stress questionnaire (psq) at 8-10 weeks postpartum. * dutch-speaking or understanding dutch. exclusion criteria: * gemelli pregnancy (or higher order pregnancy). * known endocrine disorder before pregnancy (diabetes-i, rheumatoid arthritis). * severe psychiatric disease (schizophrenia, borderline or bipolar disorder). * hiv. * drug or alcohol addiction problems. * any other disease resulting in treatment with drugs that are potentially adverse for the fetus and need careful follow-up during pregnancy. * no access to the internet.

Keywords: postpartum depression postpartum anxiety parental stress mindfulness mindful with your baby mother-infant interaction
nausea and vomiting after gynecologic surgery

Conditions: Postoperative Nausea and Vomiting; Gynecologic Surgery

Summary: in this cross-section study, all patients in the gynecologic ward of peking union medical college hospital will accepted a survey about the prevalence and severity of nausea and vomiting according to visual analogue scale and who classification. epidemiological, surgical, anaesthetic characteristics and post-operative treatment are considered as predictors for the post-operative nausea and vomiting. the primary objective is the incidence of nausea and vomiting. the secondary objective is the possible predictors of nausea and vomiting.


Eligibility criteria:
inclusion criteria: * aged 18 years or older * elective surgeries for gynecologic disease * good performance status * signed an approved informed consents * post-operative stay 72 hours or longer exclusion criteria: * emergency surgeries * not meeting all of the inclusion criteria
transcranial direct current stimulation combined with exercise in low back pain

Conditions: Low Back Pain; Transcranial Direct Current Stimulation

Summary: the purpose of this study is to evaluate the effects of transcranial direct current stimulation combined with pilates based exercise on chronic low back pain. this is a randomized clinical trial composed of two arms.

chronic low back pain may be associated with pathoanatomical, neurophysiological, physical, psychological and social factors. treatments that relieve the symptoms of these patients are of great importance to improve the quality of life of these individuals. thus, this study aims to evaluate the effects of transcranial direct current stimulation combined with pilates based exercise on chronic low back pain. this is a randomized clinical trial that will be composed of men and women between 18 and 65 years of age, with a history of low back pain for more than 12 weeks and a minimum pain intensity equal to 3 cm on the numerical pain scale. the volunteers will be randomized into two distinct groups: stimulation + exercise group (eg - will perform a pilates based exercise protocol combined with transcranial direct current stimulation) and sham stimulation + exercise group (sg - will perform the same exercise program combined with sham stimulation). the interventions, regardless of the group, will be carried out three times a week for four weeks. participants will be submitted to three assessments: the first (t0) will be performed before the treatment protocols; the second (t1) will be performed after the four weeks of intervention; and the third (t2) will be a follow-up one month after the end of the treatment protocol. pain sensation, functional performance, central sensitization, quality of life, pressure pain threshold, global impression of change, adverse events and medication use will be evaluated. for the statistical analysis, a mixed model anova will be performed for the inter and intragroup comparison, with tukey's post hoc, considering a significance level of 5%.

Eligibility criteria:
inclusion criteria: * men and women with chronic nonspecific low back pain (for more than 12 weeks) and minimum pain intensity of 3 on numerical pain rating scale. exclusion criteria: * diagnosis of fracture and spine pathologies, fibromyalgia, spine surgery in the last year; * low cognitive level assessed by the mini mental state examination; * presence of central neurological diseases (such as parkinson's and stroke) or psychiatric (such as depression or schizophrenia); * history of epileptic illness; * seizure history; * brain implants; * pacemaker; * pregnancy.

Keywords: transcranial direct current stimulation low back pain exercise chronic pain combined modality therapy motor cortex
kidney injury in times of covid-19 (kidcov)

Conditions: SARS-CoV Infection; Covid19; Corona Virus Infection; Acute Kidney Injury; Kidney Injury

Summary: there is an unmet need to evaluate the impact of sub-clinical/mild covid19 disease in the outpatient setting on prevalent and incident renal injury, as this data is currently unavailable. to capture the diversity of race/ethnic risk and covid19 related municipal shelter-in-place guidance, the investigators will enroll covid19-negative and covid19-positive samples balanced by race/ethnicity from 3 different states, california, michigan, and illinois. study endpoints will be assayed from urine samples mailed to the study team at 2, 6, and 12 months after their date of pcr test, with no requirement for these individuals to leave their homes to participate.

kidcov is a longitudinal cohort study that will prospectively follow cohorts of covid19-negative and covid19-positive adults for episodes of kidney injury over a 12-months period. study candidates will be identified via site-specific electronic medical records (emr) at seven academic medical centers in the u.s. within 4 weeks of a pcr-based test for sars-cov2. screen-positive individuals will be contacted by email or text and invited to complete an online consent form documenting their willingness to participate. participation will involve completion of questionnaires and return of urine samples in mailed collection kits at 2, 6, and 12 months after their date of pcr test. the primary endpoint will be the urine-based kit score, based on the composite measurement of multiple dna, protein and metabolite urinary biomarkers (reference). secondary endpoints include ngal and kim-1 urinary biomarkers for kidney injury assessment. early detection of new or worsening kidney injury is urgently needed in order to implement preventative measures and target therapeutics that can minimize excess post-covid19 kidney damage. a complete and standardized understanding of the trajectory and risk factors for kidney injury associated with covid19+ disease is critical to informing the design and implementation of preventative and therapeutic strategies for covid19-mediated kidney injury.

Eligibility criteria:
inclusion criteria: * result of pcr-based covid-19 test conducted in the past 4 weeks posted in emr of participating amc * age 18 years or older at enrollment * race/ethnicity, sex, age, and phone and/or home/email address provided exclusion criteria: * failure of a candidate participant to give written informed consent to comply with the study protocol * hospitalization up to 4 weeks after sars-cov-2 test * history of kidney transplant * history of dialysis

Keywords: sars-cov-2 acute kidney injury covid-19 coronaviurs covid-19 infection sars-cov-2 infection coronavirus infection covid-19 and acute kidney injury sars-cov-2 & kidney injury risk factors kidney injury
the effects of vibration and pressure interventions

Conditions: Anxiety

Summary: this study aimed to evaluate two methods (pressure and vibration intervention) used to reduce pain during im injections in children.

objectives: this study was conducted to evaluate the effects of the vibration and pressure intervention for reducing pain during intramuscular (im) injections in children. design: the study was conducted via a randomized controlled design. setting: the study population consisted of children in the five to 10 age group admitted to the emergency department of a public hospital (samsun education and research hospital) between august 2022 and october 2022 and who received an im injection as part of the medical treatment in child emergency department. interventions: the study data were collected from the children, who were divided into vibration intervention group, pressure intervention group, and control groups. main outcome measures: the children's pre-procedure fear and anxiety levels were evaluated using the children's fear scale (cfs), and children' anxiety meter state. then, their pain levels during the procedure were evaluated using the wong-baker faces rating scale.

Eligibility criteria:
inclusion criteria: * had no diagnosed physical or mental disability or chronic illness; * had no communication problems; * received single injection, * required seftriakson group of antibiotics for standardization; and received vastus lateralis muscle injection during the study. exclusion criteria: * parents who were unable to collaborate in the fear and pain evaluation, * overweight or underweight children (under the third or above the 97th percentile), * children with any incision or scar tissue in the injection area, * children who received a sedative, analgesic, or narcotic drugs (based on expert opinion) six hours before the procedure on the basis of parental statements and medical history

Keywords: anxiety fear pain
cost- effectiveness of a face-to-face rehabilitation program vs an telemedicine program in chronic low back pain

Conditions: Low Back Pain

Summary: perform a cost-utility analysis in patients with chronic low back pain through electroanalgesia treatment and exercises administered by telemedicine program versus face-to-face program

a double blind clinical trial will be developed in a sample of 80 subjects with chronic low back pain. patients will receive 3 weekly sessions of electroanalgesia and an exercise program for 8 weeks, for a total of 24 sessions. the aim is to analyze the cost- effectiveness of a face-to- face rehabilitation program vs a telemedicine program on disability, pain, fear of movement, quality of life, resistance of the trunk flexors, lumbar mobility in flexion and muscular electrical activity.

Eligibility criteria:
inclusion criteria: * low back pain ≥ 3 months. * age between 30 and 67 years old. * not being receiving physical therapy. exclusion criteria: * presence of lumbar stenosis. * diagnosis of spondylolisthesis. * diagnosis of fibromyalgia. * treatment with corticosteroids or oral medication in recent weeks. * history of spine surgery. * contraindication of analgesic electrical therapy. * have previously received a treatment of electrical analgesia or exercise. * central or peripheral nervous system disease.

Keywords: low back pain electroanalgesia mckenzie method telemedicine study protocol for a randomized clinical trial
a real-world observational study to compare effectiveness of deucravacitinib vs apremilast in adults with plaque psoriasis

Conditions: Psoriasis

Summary: the purpose of this study is to understand the comparative effectiveness of deucravacitinib versus apremilast in adults with plaque psoriasis.


Eligibility criteria:
inclusion criteria: * have been diagnosed with plaque psoriasis by a dermatologist * newly initiating an eligible medication for enrollment (i.e., deucravacitinib, apremilast) * actively enrolled in the corevitas psoriasis registry and have documented consent to allow copies of information from the registry be used for research purposes exclusion criteria: * participation (current or planned) in an interventional clinical trial (does not include observational registry or study) * restart of treatments with the study eligible therapies previously received at any time during the participants' treatment history

Keywords: real-world deucravacitinib observational
phone-based intervention under nurse guidance after stroke 2

Conditions: Blood Pressure; Stroke; Cardiovascular Diseases

Summary: the overall objective of phone-based intervention under nurse guidance after stroke ii (pings-2) is to deploy a hybrid study design to firstly, demonstrate the efficacy of a theoretical-model-based, mhealth technology-centered, nurse-led, multi-level integrated approach to substantially improve longer term bp control among 500 recent stroke patients encountered at 10 hospitals in ghana. secondly, pings ii seeks to develop an implementation strategy for routine integration and policy adoption of mhealth for post-stroke bp control in a lmic setting. the investigators will leverage experience gained from the nih global brain disorders funded r21 pilot study (ns094033) to test efficacy of a refined, culturally-tailored, and potentially implementable intervention aimed at addressing the premier modifiable risk for stroke \& other key variables in an under-resourced system burdened by suboptimal care \& outcomes.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years (stroke is commoner above this age cut-off) * male or females (sex is a biologic variable of interest) * recent stroke (within one month of symptom onset)- stroke may be ischemic or hemorrhagic based on brain imaging or diagnosed clinically using the locally validated version of the 8-item questionnaire for verifying stroke free status (8-qvsfs) when neuroimaging is not feasible * uncontrolled htn (sbp ≥ 140 mmhg at both the last clinical encounter post-stroke and the eligibility screening visit) - sbp is used as the selection variable since most african hypertensives \<60 years have systolic or combination systolic/ diastolic htn and for most patients, controlling sbp also results in dbp control * patients or family carers should own a basic mobile phone that can receive text/audio messages. exclusion criteria: - any condition that would limit participation in follow up assessments, such as severe cognitive impairment/dementia (mmse ≤24).
the primary objective of this study was to investigate the effect of insulin on myocardial perfusion and cardiac function in patients undergoing cardiac surgery for cpb using transesophageal echocardiography (tee) to detect csbf

Conditions: Insulin

Summary: the primary objective of this clinical trial was to investigate the effects of insulin on myocardial blood flow reflected by csbf which was evaluated by tee. the second aim was to observe the effect of insulin on cardiac function and markers of myocardial damage.


Eligibility criteria:
inclusion criteria included 1. age 55-80 years, asa grade ii-iii, regardless of gender, 2. bmi 18.5-28.0 kg/m2, 3. scheduled for elective coronary artery bypass grafting (cabg), valve repair or replacement, or a combination of these procedures with cardiopulmonary bypass. exclusion criteria 1. non-first cardiac surgery; 2. emergency cardiac surgery; 3. severe heart failure with preoperative left ventricular ejection fraction \<30%; 4. contraindication to tee; 5. kidney disease requiring replacement therapy; 6. combined with multi-organ insufficiency; 7. severe infection requiring continuous antibiotic treatment; 8. use of large doses of hormone or nonsteroidal anti-inflammatory drugs within the last 2 weeks. 9. after the patient entered the operating room, if the first blood glucose exceeded 180 mg/dl, a second test was performed 15 minutes later, and if the average of the two blood glucoses exceeded 180 mg/dl, the patient was excluded as well. elimination criteria included 1. unplanned secondary cpb; 2. need for intra-aortic balloon pump technical support during the study period; 3. tee image acquired with poor quality.

Keywords: insulin perioperative period blood glucose heart protection