Kornimate/medical-research-clean huggingface dataset:
advocates for all youth

Conditions: Depression, Anxiety; Self Efficacy; Suicidal Ideation

Summary: advocates for ally youth (ally) is a universal, school-based, multicomponent positive psychology program aimed to increase youth's well-being and reduce symptoms of psychological distress including depression, anxiety, and stress.


Eligibility criteria:
inclusion criteria: * students enrolled at participating schools exclusion criteria: * none
efficacy and safety of lidocaine infusion treatment in management of neuropathic pain

Conditions: Postherpetic Neuralgia; Diabetic Polyneuropathy; Peripheral Neuropathy

Summary: the investigators conducted a randomized, double blind, and controlled study to evaluate the efficacy and safety of lidocaine infusion treatment in management of neuropathic pain.

the investigators expect pain improvement after treatment with 3 mg/kg of lidocaine, continuously infused in normal saline 250 ml.

Eligibility criteria:
inclusion criteria: * postherpetic neuralgia, diabetic polyneuropathy, peripheral neuropathy * nrs score \> 4 * stable oral medication during the 1 month trial period * volunteers with informed consent exclusion criteria: * pregnancy, breastfeeding, possibility of pregnancy * pain from causes other than upper 3 indications * hypersensitivity to lidocaine or other local anesthetics * important disease of heart, kidney, liver or incurable disease that may affect the assessment of adverse effects, or may interfere with the completion of study * severe conduction block * history of other interventions that may affect the study * enrollment in other clinical trials within 30 days * otherwise not suitable to study

Keywords: lidocaine infusion therapy
the long-term results of the no-touch vein graft to the left anterior descending artery.

Conditions: Ischemic Heart Disease; Atherosclerosis

Summary: the purpose of this study was to investigate whether the no-touch saphenous vein grafts that were used in coronary artery bypass surgery between 2003-2008 had a patency rate comparable to the left internal thoracic artery when the vein grafts were anatomised to the left anterior descending artery.


Eligibility criteria:
inclusion criteria: 1. coronary artery bypass grafting performed at the department of cardiothoracic surgery, örebro universtiy hospital between 2003-2008. 2. saphenous vein graft harvesting using the no-touch technique. 3. the saphenous vein anastomised to the left anterior descending artery. 4. informed consent exclusion criteria: 1. allergy to contrast media. 2. impaired renal function. 3. inability to conduct the study according to protocol.

Keywords: coronary artery bypass grafting saphenous vein grafts
ctdna monitoring in early breast cancer

Conditions: Breast Cancer

Summary: this is a observational, single center study, monitoring the circulating tumor dna (ctdna) in patients with early breast cancer and assessing the prognostic value and treatment outcome monitoring of ctdna.


Eligibility criteria:
inclusion criteria: 1. patients aged 18 to 80 years old 2. histologically proven primary breast cancer with clinical stage i-iii 3. patients with neoadjuvant therapy, and/or radical surgery/breast conserving surgery, adjuvant chemotherapy and target therapy (her2+), radiotherapy (if indicated). 4. expected to achieve r0 resection. 5. estimated lifetime is more than 3 months. 6. signed informed consent form 7. consent to provide research blood samples. exclusion criteria: 1. patients intended to receive adjuvant chemotherapy with eastern cooperative oncology group (ecog) performance status 3, 4 or 5. 2. patients intended to receive postoperative radiotherapy with eastern cooperative oncology group (ecog) performance status 5. 3. prior diagnosis of cancer in the previous 5 years, other than for basal cell carcinoma of the skin or cervical carcinoma in situ. 4. presence of any systemic illness incompatible with participation in the clinical trial or inability to provide written informed consent.

Keywords: ctdna
impact of misoprostol on blood loss in myomectomy operations

Conditions: Leiomyoma

Summary: the aim of this research work is to assess the effect of using single preoperative dose of rectal misoprostol in abdominal myomectomy operations on blood loss, duration of the operation and possible operative complications

this study is a randomized, double-blind, controlled study that will be conducted in ain shams university maternity hospital. a total of 50 women scheduled to undergo myomectomy for symptomatic uterine myoma will be included in this study after taking their consent for this clinical trial after full explanation of the trial. the total of 50 included patients will be divided into two groups: group a (study group;): will include 25 patients undergoing myomectomy operation will receive two tablets of misoprostol (400 mcg) rectally two hours before the operation.group b (control group): will include 25 patients undergoing myomectomy operation will not receive misoprostol before the operation.

Eligibility criteria:
inclusion criteria: * premenopausal patients aged between 35 to 50 years old. * five or less symptomatic uterine myomas . * maximum diameter of the largest myoma is 6 cm . * all myomas are subserous or intramural. * uterine size less than 24 weeks pregnancy exclusion criteria: * history of previous surgery. * allergy to misoprostol. * hypertension. * cardiac and pulmonary diseases. * patients who have bleeding disorders. * anemia (hb \< 10g %). * chronic endocrine or metabolic diseases such as diabetes. * obesity (body mass index \> 30 kg/m2). * cases that will require intraoperative conversion of myomectomy to hysterectomy.
effect of heart-lung-machine on selenium status of cardiac surgical patients undergoing coronary bypass surgery

Conditions: Selenium Level

Summary: since selenium has demonstrated significant characteristics for a series of biochemical processes, for antioxidant activity and immune stimulation, this observational study should represent the effect of heart-lung-machine on selenium status of cardiac surgical patients undergoing coronary bypass surgery. it will be examined in (approximately 100) adult patients, under which 50 patients are operated conventionally (meaning with the use of heart-lung-machine). another 50 patients are operated on beating heart without the use of heart-lung-machine (opcab = "off pump coronary artery bypass"). the allocation of individual patients in these two groups is done according to clinical criteria and is undertaken by the operating surgeon.

to produce two comparable groups of patients, the characteristics are recorded using euro-score; additionally the groups are "matched" (matched-pairs-analysis). all patients are operated by the same surgeon (senior physician dr. a.k. menon) under general anaesthesia through median sternotomy with elective or urgent indications. after induction of anaesthesia, within the first hour after admission to the intensive care unit (icu) and every further morning in the icu or intermediate care station (imc), 10ml blood are removed by a central venous catheter, allowing to measure blood selenium levels in whole blood by electrothermal atomic absorption spectrometry. all blood draws will be held on vascular access, which is lying independently of the study participation for surgery or for intensive care treatment. the blood samples will be stored until completion of the study and its evaluation (up to 24 months) and are discarded afterwards. all data collected are recorded on a documentation sheet.

Eligibility criteria:
inclusion criteria: * coronary-3-vessel-disease * written informed consent * age of 18 years or older * study inclusion at the latest on the last evening before surgery exclusion criteria: * other serious cardiac diagnosis (i.e. aneurysm, valvular-diseases) * ischemic cardiomyopathy * patients not capable of consenting * pregnant or lactating women, women of child-bearing potential in whom pregnancy can not be excluded

Keywords: inflammation parameters various blood values clinical outcome residence in icu/ hospital saps-score sofa-score duration of artificial respiration
managing infliximab reinduction after temporary discontinuation of drug

Conditions: Inflammatory Bowel Disease

Summary: the primary purpose of the project is to determine what is the best schedule for restarting infliximab in patients with inflammatory bowel disease (ibd) specifically ulcerative colitis and crohn's disease, who have undergone infliximab infusions before. the primary endpoint would be the failure rate; the need to discontinue infliximab or change treatment. a secondary aim will be to determine if infliximab drug and antibody levels can predict clinical outcomes at 1 year. other secondary outcomes include comparing short-term and long-term steroid free remission rate, and serum and fecal inflammatory markers in response to infliximab.


Eligibility criteria:
inclusion criteria: * subjects 18 years or older who are willing and able to provide informed consent * history of ibd (crohn's disease, ulcerative colitis, indeterminate colitis) by standard clinical, histological, and radiographic date. * history of stable clinical response to prior ifx induction and regular maintenance dosing, as determine by enrolling clinician. * prior to drug holiday, was on stable dose of infliximab for at least 3 infusions at regular maintenance intervals * infliximab drug holiday for at least 12 weeks. exclusion criteria: * inability or unwillingness to provide informed consent * pregnant patients * prior history of serious infusion reaction to ifx

Keywords: influximab ifx remicade
evaluation of diagnostic performance of cerebral perfusion scans in pseudo-stroke

Conditions: Stroke, Acute

Summary: when a patient is received with the context of acute stroke, they undergo a fast neurological evaluation and obtain a basic appraisal composed of a non-contrast endovascular cerebral scan and an angiography scan of intracranial blood vessels and the neck. once the structural lesion (hemorrhage, tumor, etc.) is absent, signs of early infracts and confirmed acute intracranial arterial occlusion, the possibility of a pseudo-stroke dwells in the differential diagnostic. certain characteristics of history and clinical evaluation create sufficient doubt to evoke the possibility of a pseudo-stroke. in fact, this population is mostly female and the cardiovascular risk factors are less prevalent in this group than for the group of stroke victims. it is on average the youngest and presents a less severe deficit. for the rest, medical antecedents often help to evoke a diagnosis of pseudo-stroke.

with this study, the investigators wish to evaluate the diagnostic value of two additional radiological examinations: 1. computed tomography perfusion (ctp) imaging to evaluate blood flow in the brain; 2. imaging by magnetic resonance (mri) of the brain to detect lesions from a cerebral vascular accident (stroke) not visible on standard imaging of the brain. the proposed additional examinations (ctp and mri) are tests that are currently used at the chum. those are not experimental tests. these tests are commonly used when doctors wants a further investigation to clarify the cause of the neurological symptoms. these tests are usually done in a semi-urgent or non-urgent situations. in the present study they will be done urgently. the investigators wish to determine if obtaining these additional tests in emergency will change the decision of whether to administer the drug (thrombolysis). the investigators want to determine whether one imaging test is sufficient or if both exams are needed to help clinical decision-making. please note that urgent access to perfusion ct and brain mri is not considered routine care, since the value of these additional tests has yet to be demonstrated.

Eligibility criteria:
inclusion criteria: 1. admission at chum for acute neurological deficit \<4,5h (since the onset of symptoms) 2. potential candidate for an intravenous thrombolysis 3. cerebral angioscan performed at chum at the time of admission 4. age ≥ 18 years 5. observed period from september 2019 à june 2020 exclusion criteria: 1. contraindication to intravenous thrombolysis according to the doctor in charge of treatment; 2. indication of a thrombectomy; 3. incomplete exam or exam of insufficient technical quality for a reliable radiological interpretation; 4. contraindication against mri .
study of the mechanisms of metabolic adaptations to overfeeding

Conditions: Obesity; Diabetes

Summary: obesity results from complex interactions between genetic and environmental factors, and are strongly associated with metabolic complications such as type 2 diabetes mellitus. obesity is defined as an excessive fat accumulation that presents a risk to health, a risk that is highly dependent upon the type of adipose tissue accumulation, whether visceral or sub-cutaneous, but also upon the characteristics of the fat tissue, especially inflammatory cells accumulation. because of the well known sexual difference in fat accretion, this obesity-associated risk may also be very different for men and for women. in addition, recent data indicate that various factors such as the intestinal microbiota, but also the dietary intake of protective nutrients might be important determinants of the metabolic complications of obesity. here we propose to: 1) study the metabolic adaptations and the mechanisms of adipose tissue accumulation during a period of controlled caloric over-nutrition, both in men and in women; 2) evaluate the potential protective effects of a supplementation with polyphenols on insulin resistance and other metabolic adaptations.

to achieve these goals, healthy male and female volunteers will be enrolled into a one month longitudinal, prospective study on the influence of hypercaloric overfeeding (+50% of daily caloric needs) on different tissues (adipose tissue, muscle and blood). they will be separated into two different groups: hypercaloric nutrition and placebo, and hypercaloric nutrition and polyphenols (2g/day), where polyphenols administration will be randomized and administered in a double blind fashion. whole body and hepatic insulin sensitivity, total energy expenditure, glucose hepatic production, protein and gene expression in muscle, adipose tissue and blood as well as intestinal microbiota will be assessed at base line, and after one month of overfeeding.

Eligibility criteria:
inclusion criteria: * normal healthy male and female volunteer exclusion criteria: * diabetes mellitus * high blood pressure * liver disease * kidney disease

Keywords: insulin resistance type 2 diabetes obesity polyphenols adipose tissue overfeeding
retest-reliability and at-home-assessment feasibility of the 5r-sts

Conditions: Degenerative Disc Disease; Spondylolisthesis; Spondylosis; Herniated Nucleus Pulposus; Spinal Stenosis Lumbar; Spinal Diseases; Spinal Instability

Summary: the five-repetition sit-to-stand test has been validated and is used primarily in pulmonary medicine and cardiology, and has recently been shown to be a useful tool for the objective assessment of functional impairment in patients with degenerative diseases of the lumbar spine. the goal of this study is to assess the possibility of supervised and unsupervised at-home-assessment. validation of at-home-assessment would allow the 5r-sts to be easily used as a follow-up tool in clinical trials, for example.

patients will perform three 5r-sts measurements: 1. during outpatient clinics, time measured by the physician 2. at home, time measured by partner/family 3. at home, and assessed by producing a video recording of the 5r-sts performance that is subsequently sent and analyzed (time measured digitally)

Eligibility criteria:
inclusion criteria: * degenerative diseases of the lumbar spine (herniated disc, lumbar stenosis, spondylolisthesis, degenerative disc disease) * symptoms of lower back pain, neurogenic claudication, or radiculopathy exclusion criteria: * hip or knee prosthetics * walking aides
comparison between fixed- versus mobile-bearing tka

Conditions: Knee Arthritis

Summary: the purpose of the study is to analyse the clinical and radiological results of a postero-stabilized tka by using a mobile bearing versus fixed. only patients with medial femorotibial arthritis will be included. the consequences on the patellofemoral joint will be thoroughly analysed on skyline view.


Eligibility criteria:
inclusion criteria: * medial medial femorotibial arthritis requiring an arthroplasty * age between 50y and 90y exclusion criteria: * lateral femorotibial arthritis * inflammatory disease * stiff knee with flexion under 90° * revision tka * previous surgery (except meniscectomy)

Keywords: mobile-bearing arthroplasty fixed-bearing knee patella posterior stabilized tka
the preventive effect of different doses of intranasal insulin on postoperative delirium

Conditions: Postoperative Delirium

Summary: postoperative delirium is one of the common complications in the older aldults after surgery, which can lead to longer hospita stay，memory loss and reduced quality of life. there is currently no specific treatment. therefore, it is important to prevent the occurrence of postoperative delirium. this study investigated the effect of intranasal insulin administration on the prevention of postoperative delirium and compared different doses of insulin to find a safe and acceptable method for preventing delirium.

hip fractures are a common trauma in older adults and occur mainly in older people with osteoporosis. surgery is the preferred choice for the vast majority of patients with severe pain and limited mobility in older aldults with hip fractures, resulting in higher mortality and disability rates with conservative treatment. but postoperative delirium becomes a challenge. at present, the treatment of delirium includes pharmacological and non-pharmacological methods, but the effect is limited, and now the focus is on preventing delirium, so this study investigated the effect of intranasal insulin administration on the prevention of postoperative delirium.

Eligibility criteria:
inclusion criteria: patients with hip fracture scheduled for unilateral hip arthroplasty or intramedullary nailing under subarachnoid block. both genders. age ≥65 years old. body mass index (bmi) ≤24kg/m2. american society of anesthesiologists (asa) grade i-iii. exclusion criteria: contraindications to nasal administration (nasal defects or lesions). history of insulin allergy. inability to communicate preoperatively (coma, severe visual or hearing impairment). history of severe heart,liver and kidney disease. history of psychiatric disorders. preoperative delirium. multiple traumas or fractures. contraindications to subarachnoid block.

Keywords: postoperative delirium insulin intranasal administration
early continuous renal replacement therapies (crrt) in patients with severe sepsis or septic shock with acute kidney injury

Conditions: Severe Sepsis; Septic Shock; Acute Kidney Injury

Summary: severe sepsis or septic shock with acute kidney injury shows high mortality in intensive care unit. a few studies have shown crrt relating the clinical improvement seems to be related to the early initiation of therapy. but there is no consensus for proper time of crrt may improve the prognosis. the study is a prospective randomized one center trial comparing two treatments in patients suffering from septic shock complicated with acute renal failure admitted to icu, treated either early by crrt (35 ml/kg/h) or by conventional rrt.


Eligibility criteria:
inclusion criteria: * septic shock (bone criteria) for less than 14d * rifle criteria : injury or failure or nearly anuria more than 2hr * age over 18 years * written informed consent by next of kin. exclusion criteria: * cirrhosis child class c * crf or esrd * too high apache ii \& sofa score at admission * age over 80 years * life expectancy less than 3 months (metastatic cancer - hepatoma, lung ca.)
microsurgical breast reconstruction & vte

Conditions: Breast Reconstruction; Venous Thromboembolism

Summary: venous thromboembolism (vte) encompasses pulmonary embolism (pe) and deep venous thrombosis (dvt) and continues to be a major patient safety issue after reconstructive plastic surgery. significant morbidity and mortality is associated with vte events. this disease entity represents the most common cause of preventable in-hospital death as evidenced by over 100,000 annual vte-related deaths in the u.s. the associated economic burden is substantial, with annual costs to the u.s. healthcare system in excess of $7 billion. cancer patients have been identified as a particularly vulnerable patient population. of these, breast cancer patients represent the largest group treated by plastic surgeons. an increasing number of breast reconstructions are performed in the u.s. with a documented 35% increase in the annual number of breast reconstructions since 2000. over 106,000 breast reconstructions were performed in 2015 alone. of all reconstructive modalities, autologous breast reconstruction using abdominal flaps is associated with the highest risk for vte. we believe that a key element rendering these patients susceptible to postoperative vte is inadequate duration of chemoprophylaxis. this is supported by the observation that vte risk remains elevated for up to 12 weeks postoperatively. we hypothesize that lower extremity deep venous system stasis is a procedure-specific key contributing factor to postoperative vte risk. this study examines the duration of postoperative lower extremity venous stasis to identify patients who might benefit from extended chemoprophylaxis. we will use duplex imaging technology to examine the lower extremity deep venous system preoperatively, on postoperative day 1, and on the day of discharge to determine if patients display radiographic evidence of lower extremity venous stasis at the time of hospital discharge. a better understanding of pathophysiologic mechanisms that contribute to the development of vte as well as surgical means that reduce vte risk factors have the potential to optimize vte prophylaxis, thus, favorably impacting clinical outcome in a large patient population.


Eligibility criteria:
inclusion criteria: * see study population description exclusion criteria: * superficial inferior epigastric artery flaps * donor-sites other than the abdomen * chronic obstructive pulmonary disease (copd) * liver disease.