Kornimate/medical-research-clean huggingface dataset:
effects of 'nhgdoc' on quality of care

Conditions: Heart Failure

Summary: the purpose of this study is to determine whether the computerized decision support system 'nhgdoc' is effective in improving quality of primary care in terms of processes of care (e.g. prescribing behavior of physicians) as well as outcomes of care (e.g. hospital admissions, mortality).

computerized decision support systems are regarded as useful tools to improve quality of care, but their effects are still uncertain. in the netherlands 'nhgdoc' a computerized decision support system supported by the dutch college of general practitioners (nhg) is currently being implemented among more than 1.000 general practices in the netherlands. the aim of this study is to evaluate the effects of nhgdoc on quality of care. in addition, we want to gain insight into the barriers and facilitators that affect the systems' impact. a cluster randomized controlled trial will be conducted among 120 general practices in the netherlands. eligible practices will be randomized to receive either the regular nhgdoc modules (control arm) or the regular modules and an additional module on heart failure (intervention arm). the effect evaluation will focus on processes of care (e.g. prescription behavior) as well as on patient outcomes (e.g. hospital admissions, mortality). additionally, a process evaluation will be conducted, which includes a focus group study and a survey among participating healthcare providers to evaluate the perceived barriers and facilitators to using 'nhgdoc'. results of this study will provide insight in the ability of computerized decision support systems and in particular 'nhgdoc' to improve quality of primary care. whereas the trial focuses on a specific nhgdoc domain - heart failure - we believe our conclusions are relevant to other primary care areas as well, particularly as this study also explores the factors that contribute to the systems' effectiveness.

Eligibility criteria:
inclusion criteria: * general practices should use the information system microhis x or promedico asp * nhgdoc should be available in the general practices exclusion criteria: * general practices that do not meet the inclusion criteria

Keywords: computerized decision support system heart failure effects on quality of care process of care patient outcomes
safety and efficacy reconyl for cough with/without sore throat

Conditions: Cough

Summary: this study is a prospective, randomized, double-blind and placebo-controlled study to find out if reconyl may relieve the acute cough with/without sore throat.

reconyl is a mixed extract from 4 indonesian herbs, vitex trifolia (legundi), zingiber officinale var. amarum (jahe gajah), abrus precatorius (saga), and phaleria macrocarpa (mahkota dewa), which have been known traditionally to relieve cough, respiratory congestion, and sore throat. there will be two parallel groups of 30 subjects per group (a total of 60 subjects) planned to be enrolled in this study. the investigational product: tablets @ 225 mg of reconyl. dose administration: one tablet of reconyl or placebo, given 3 times daily, for 3 days. eligible subjects will be instructed to perform a daily self-assessment on the cough symptoms over the 3 days of treatment, in the subject diary. subject shall return to the study clinic 3 days ± 24 hours after the first dose, for completion of the subject's participation in the study.

Eligibility criteria:
inclusion criteria: 1. healthy men or women aged 18 to 60 years with cough with/without sore throat with a maximum onset of 3 days. 2. signing the informed consent. exclusion criteria: 1. body temperature of \> 37.3˚c and/or refuse to follow health protocol for covid-19 2. known hypersensitivity to herbal drugs 3. pregnant or lactating women 4. have received any anti-inflammatory or cough-alleviating drugs within the past 24 hours 5. presence of vomiting or diarrhea within the past 24 hours and still ongoing at the start of study 6. severe illness, e.g. severe hypertension, any other chronic infections or diseases that may induce cough, such as: pulmonary tuberculosis, gastrointestinal reflux diseases (gerd)

Keywords: cough with sore throat cough without sore throat reconyl
ultrasonographic bladder wall thickness and different forms of detrusor overactivity

Conditions: Detrusor Overactivity

Summary: in the last decade, several authors proposed ultrasound measurement of bladder wall thickness (bwt) for the screening of the voiding dysfunction and of the detrusor overactivity (do). the aims of the investigator prospective study were: * to compare the ultrasonographic measurement of bwt in women with do vs women with other urodynamic diagnosis in a very large population. * to verify whether the bwt in women with do can be different in the clinically or urodinamically different forms of do.


Eligibility criteria:
inclusion criteria: * all women referred to our urogynecology unit from january 2005 to december 2008 for symptoms of oab, stress urinary incontinence or mixed incontinence and sottoposte a prove urodinamiche complete were included in this prospective study exclusion criteria: * the investigators excluded women with documented recurrent urinary tract infections * previous antimuscarinic treatment * previous pelvic surgery * neurological disease * vaginal prolapse \> i stage * symptoms or clinical and/or urodynamic signs of voiding dysfunction * patients included in other ongoing clinical trials during the same study period.
antihistamines, amantadine and evolution of the sars-cov-2 infection

Conditions: COVID-19

Summary: the rates of symptomatic covid19 infection, hospital admission among covid19 cases and survival would be quantified in patiens chronically treated with antihistamines or amantadine, with the aim of determining the role of antihistamines and amantadine in the evolution of covid19.

background: according to previous reports, all 84 eldery residents in nuersing homes in yespes (toledo, spain), had a 100% of positive serology for covid-19 in june 2020, but none died nor hospitalized after receiving early treatment with antihistamines. other case reports have suggested a protective role of amantadine, since infected patients showed a very mild covid19 infection. objectives.determine the role of antihistamines and amantadine in the evolution of covid19. methods. describe the rate of hospitalization, icu, survival, postcovid syndrome and thrombosis among covid 19 cases having antihistamines and amantadine as chronic treatments. the rates would be stratified by age groups and compared with the same age groups of the population assigned to the public free access terrassa health consortium.

Eligibility criteria:
inclusion criteria: patients having chronic treatment with antihistamines or amantadine - exclusion criteria: none -

Keywords: antihistamines amantadine hospital admissions survival
ptsd prevention study examining the efficacy of sertraline in burn victims

Conditions: Post-traumatic Stress Disorder

Summary: this is a randomized, double-blind, placebo-controlled study to determine whether administration of sertraline to patients who exhibit acute stress disorder secondary to severe burns can contribute to the prevention of post-traumatic stress disorder (ptsd).


Eligibility criteria:
inclusion criteria: * victim of a traumatic event leading to personal injury * patient experienced a feeling of intense fear, hopelessness, or horror during the course of the event or immediately afterward * positive screen on the asds (for inclusion in the randomization phase); a total asds score of ≥ 37 (including a dissociative score of ≥ 9) will be counted as a positive screen. exclusion criteria: * age \< 18 * pregnant women, lactating women, or women not using acceptable form of birth control * epilepsy or head trauma resulting in seizures * current or historical schizophrenia, bipolar disorder, mental retardation, ocd, eating disorders, dementia, delirium, or self-injurious behavior * current/previously diagnosed ptsd * history of hypersensitivity to sertraline * trauma occurring \> 7 days prior to likely first treatment in the randomization phase of the trial. * unable to provide informed consent for participation in the study protocol. * patient at high risk of recurrent bleeding despite surgical stabilization * patient with a history of serotonin syndrome * patient non-fluent in english * patient currently prescribed an antidepressant (any ssri, snri, tca, maoi, mirtazapine, or trazodone in excess of 100mg per day)

Keywords: posttraumatic stress disorder ptsd sertraline burns
the effect of two non-pharmacological methods on pain and anxiety experienced during intrauterine device application.

Conditions: Intrauterine Devices

Summary: the purpose of this study is to determine the effect of emotional freedom technique and music, which are effective in relieving pain and anxiety, on the pain and anxiety that occur during intrauterine device application.

intrauterine devices, which are considered one of the most effective contraceptive methods, can be effective up to 99% when used correctly. while 17% of women of reproductive age around the world use intrauterine devices, 13.7% of women in our country prefer intrauterine devices as a contraceptive method. intrauterine devices have many benefits such as being easy to use, returning fertility when removed, being able to be used for a long time, and being low in cost. intrauterine devices are recommended to women as the first choice by medical institutions due to their high effectiveness rates. however, anxiety and pain experienced during the intrauterine device placement procedure may prevent women from choosing intrauterine devices as a birth control method. music and emotional liberation techniques can be used as alternative methods to relieve pain and anxiety. in this research, the effects of emotional freedom technique and music, which are effective on pain and anxiety, on pain and anxiety during intrauterine device application will be investigated. additionally, it will be tested whether the emotional liberation technique and music are superior to each other in relieving the pain and anxiety that occur during intrauterine device application. additionally, no research has been found in the literature examining the effects of emotional liberation technique and music recital on the pain and anxiety experienced during intrauterine device application. with this research, the gap in the field will be eliminated and new research and applications will be structured.

Eligibility criteria:
inclusion criteria: * voluntarily agreeing to participate in the research * being between the ages of 18-49 exclusion criteria: * having a verbal communication problem * being medically diagnosed with a psychiatric disorder * presence of wounds, scars and infections in the areas touched in the emotional freedom technique * having a hearing problem * having had an intrauterine device (iud) inserted before * being exposed to domestic violence * being diagnosed with any medical condition (hypertension, diabetes, etc.) * having used analgesics seven hours before the procedure * having a gynecological examination just before iud application

Keywords: intrauterine device pain anxiety emotional freedom technique music nursing
hemodynamic response after six months of sildenafil

Conditions: Pulmonary Arterial Hypertension

Summary: the purpose of this study is to determine the clinical, functional and hemodynamic response after six months of sildenafil 50 mg tid in patients with pulmonary arterial hypertension.

pulmonary arterial hypertension is a chronic devastating disease. there are few approval oral treatments. sildenafil, a phosphodiesterase 5 inhibitors, has been recently approved for patients on functional class ii and iii showing hemodynamic benefits after 12 weeks of treatment. long term hemodynamic evaluation after sildenafil treatment has not been evaluating in pulmonary arterial patients on functional class ii to iv. the protocol has been designed to evaluate patients on functional class ii to iv from baseline conditions and after 6 months of sildenafil treatment (50 mg po tid). clinical (functional class), functional (walked distance-6 minute walking test) and hemodynamic evaluation is planned to be performed at baseline and after 6 months of treatment.

Eligibility criteria:
inclusion criteria: * patients older than 15 years old with pulmonary arterial hypertension according with who hemodynamic definition, * who signed informed consent, * able to swallow tablets and follow instructions. exclusion criteria: * patients with pulmonary hypertension with other categories than pulmonary arterial hypertension (associated to copd, lund diseases, sleep apnea, thromboembolic disease, hight altitude), patients asymptomatic, patients who were responders to adenosine during hemodynamic test, patients treated with specific treatments for pulmonary arterial hypertension before started the study such as sildenafil, prostanoids, endothelin receptors blockers.

Keywords: hemodynamic pulmonary hypertension sildenafil
positive action for today's health

Conditions: Obesity

Summary: regular moderate and vigorous intensity physical activity (pa) is inversely related with obesity, however, few adults are successful in incorporating sufficient pa into their daily lives. minority and lower-income adults have among the highest obesity rates and lowest levels of regular pa. increasing environmental supports for safe and convenient places for pa is an emerging public health strategy for pa interventions. preliminary data by wilson (pi) and colleagues has revealed through focus groups that low-income minority adults would like to increase the safe places for pa (areas free from crime, containment of stray dogs, increased police patrol) and access to pa (sidewalks/trails and expand opportunities for pa) in their community. in addition, the results of the investigators' preliminary studies suggest that african americans had psychosocial barriers to pa that included lack of self-motivation, cultural body image issues, and lack of time due to family obligations. the present proposal is innovative in that it specifically tests the efficacy of an intervention that includes both patrolled-walking and social marketing elements to increase pa in low-income african americans. three communities will be randomized to receive one of three programs: a police patrolled-walking program plus social marketing intervention, a police patrolled-walking only intervention, or no walking intervention (general health education only; n=390; 130/group). the 24-month intervention will focus on increasing safety (training community leaders to serve as walking captains, hiring off-duty police officers to patrol the walking program, and containing stray dogs), increasing access for pa (marking a walking route), and will include a tailored social marketing campaign for increasing pa (in one intervention community). the investigators will collect data for pa (7-day accelerometer estimates, 4-week pa history), body composition, blood pressure, psychosocial measures, and perceptions of environmental supports for safety and access for pa at baseline, 6-,12-,18-, and 24-months. the primary hypotheses are that the patrolled-walking plus social marketing intervention will result in greater increases in moderate and vigorous pa as compared to a patrolled walking only intervention or no-intervention by 12-months and that these effects will be maintained at 18-month and 24-month assessments.


Eligibility criteria:
inclusion criteria: * african american (3 of 4 grandparents are of african descent) * lives in designated census area * no plans to move in the next two years * has no medical condition that would limit participation in moderate intensity exercise including life-threatening illness (e.g., immobile, severely disabled, or bed ridden) * available and able to participate in measures and intervention activities over the next 2 years exclusion criteria: * extreme blood pressure and/or blood glucose levels * unable to take a brisk, 30-minute walk
fmri feasibility older hip fracture surgery

Conditions: Magnetic Resonance Imaging; Hip Fractures; Postoperative Delirium

Summary: an assessment of the feasibility of structural and functional magnetic resonance imaging (mri) brain scans in older people who have recovered from and older people who never had delirium after hip fracture surgery

postoperative delirium, an acute sate of confusion occurs with higher frequency in older people. hip fracture surgery is a procedure associated with an increased risk of postoperative delirium. in the study the feasibility of achieving structure and functional connectivity imaging of the brain, using magnetic resonance imaging, in older people who are recovering from hip fracture surgery will be assessed. people who have recovered from post operative delirium and people who did not have postoperative delirium will be included.

Eligibility criteria:
inclusion criteria:age * age ≥ 65 years * cognitively intact * primary admission for hip fracture surgery exclusion criteria: * cognitive impairment * less than moderate level of activities of daily living * history of neurosurgery/significant head trauma * acutely unwell/moribund * presence of neurological diseases including overt stroke, dementia, multiple sclerosis, parkinson's disease, intracranial tumours and other significant neurologic disorders. * postural or movement disorders likely to impede mri scan * contraindications to mri * complex fractures/multiple injuries

Keywords: older people postoperative delirium functional mri
manual therapy effects on upper and lower esophageal sphincter pressures

Conditions: Gastroesophageal Reflux Disease; Globus Pharyngeus

Summary: the aim of this study is to test the influence of manual cervical traction and chest stabilization maneuvers on pressures in upper and lower esophageal sphincters.

high resolution manometry (hrm) will be used to measure pressure changes in upper esophageal sphincter (ues) and lower esophageal sphincter (les) during manual cervical traction and trunk stabilization maneuvers. 50-55 gastroesophageal reflux disease (gerd) subjects will participate in the study. ues and pressures will first be measured in relaxed supine position then, during manual cervical traction and finally, the subjects will undergo manual positioning of the trunk into neutral position and les and ues pressures will be measured again.

Eligibility criteria:
inclusion criteria: * gastroesophageal reflux disease exclusion criteria: * previous gastro- esophageal surgery * concomitant other chronic disease that would affect esophageal motility * esophageal structural pathology * massive hiatus hernia

Keywords: high resolution manometry globus pharyngeus gastroesophageal reflux disease manual cervical traction trunk stabilization maneuver
cognitive and hormonal treatment of sex offenders

Conditions: Paraphilia

Summary: the aim of this study is to determine if cognitive treatment and hormone treatment can change the relapse rate of sexual offenders.

the aim of this study is to determine if cognitive treatment and hormone treatment can change the relapse rate of sexual offenders. in the first part of study we are studying changes in the offenders cognitive distortions and in the second part we are studying changes in sexual activities and sexual thoughts after treatment with leuprorelin. the study is an open pre and post study.

Eligibility criteria:
inclusion criteria: men sentenced for paraphilia exclusion criteria: men above 70 years and men that does not speak english

Keywords: paraphilia hormonal treatment cognitive treatment
australian clinical study of the apnex medical hgns system to treat obstructive sleep apnea

Conditions: Obstructive Sleep Apnea

Summary: the overall goal of the study is to evaluate the safety, efficacy and therapy settings of the hgns system for stimulating the hypoglossal nerve to help maintain an open airway in subjects with obstructive sleep apnea (osa).


Eligibility criteria:
eligibility criteria 1. previously diagnosed with moderate to severe obstructive sleep apnea. 2. subject has failed or does not tolerate cpap treatment. 3. age between 21 and 70 years. 4. body mass index (bmi) less than or equal to 40

Keywords: obstructive sleep apnea osa hypoglossal nerve stimulation sleep apnea
treatment of hepatitis c in psychiatric patients

Conditions: Mental Disorders; Drug Addiction

Summary: psychiatric disorders or drug addiction are often regarded as contraindications against the use of interferon-alpha in patients with chronic hepatitis c. the investigators aim is/was to get prospective data about adherence, efficacy and mental side effects of ifn-alpha treatment in different psychiatric risk groups compared to controls. in a prospective trial, 81 patients with chronic hepatitis c (positive hcv-rna and elevated alt) and psychiatric disorders (n=16), methadone substitution (n=21), former drug addiction (n=21) or controls without psychiatric history or addiction (n=23) should be/were treated with a combination of ifn-alpha-2a 3 x 3 mio u/week and ribavirin (1000-1200 mg/day).

patients from the munich university outpatient department of psychiatry or gastroenterology as well as inpatients with elevated transaminases were tested for hcv-infection and considered for our trial to avoid a positive or negative selection. medical inclusion criteria were a detectable serum hcv-rna level in a pcr-based assay (amplicor®, roche diagnostics, branchburg, nj) for more than 6 months and an elevated alanine aminotransferase (alt \> 30 u/l, normal \<24 u/l). general exclusion criteria were the presence of other liver disease, child b or c cirrhosis, severe cardiac or neurological disease, co-infection with hepatitis b or hiv, hepatocellular carcinoma evaluated by ultrasound and alpha-fetoprotein, autoimmune disorders, a neutrophil count below 1500 per cubic millimetre, and a platelet count below 75000 per cubic millimetre.

Eligibility criteria:
inclusion criteria: * medical inclusion criteria were a detectable serum hcv-rna level in a pcr-based assay (amplicor®, roche diagnostics, branchburg, nj) for more than 6 months and an elevated alanine aminotransferase (alt \> 30 u/l, normal \<24 u/l). exclusion criteria: * general exclusion criteria were the presence of other liver disease * child b or c cirrhosis * severe cardiac or neurological disease * co-infection with hepatitis b or hiv * hepatocellular carcinoma evaluated by ultrasound and alpha-fetoprotein * autoimmune disorders * neutrophil count below 1500 per cubic millimetre * platelet count below 75000 per cubic millimetre

Keywords: interferon-alpha hepatitis c drug addiction methadone psychiatric disorder safety and efficacy of interferon-alpha i patients with a psychiatric disorder.