Kornimate/medical-research-clean huggingface dataset:
comparison of dsct with ib-ivus and angiography in the assessment of coronary artery disease

Conditions: Coronary Artery Disease

Summary: the purpose of this study is to compare different methods of looking at atherosclerotic plaques in heart arteries. identifying the characteristics of these plaques noninvasively would be very valuable. this study is looking at a new ct scanner (dsct) to noninvasively image these plaques compared to invasive ultrasound (the current standard).

the primary objectives of this study are: 1. to compare with contrast angiography, the ability of dsct to detect and quantify coronary artery stenoses. 2. to compare with gray-scale ivus, the ability of dsct to quantify plaque cross-sectional diameter \& area measurements \& plaque volume. 3. to evaluate the ability of dsct to assess plaque morphology and quantify plaque components as compared to gray-scale and ib-ivus. 4. to evaluate the ability of dsct to identify \& measure lesion remodeling compared to gray-scale ivus. 5. to determine if pre-pci evaluation of coronary plaque morphology by ib-ivus can a) predict procedural success as assessed by adequate stent strut apposition and expansion and b) peri-procedural myocardial necrosis as measured by biomarker elevation.

Eligibility criteria:
inclusion criteria: * males or non-pregnant females * \> / = 18 years of age * scheduled for coronary angiography exclusion criteria: * acute st-elevation myocardial infarction within last 72 hours * current congestive heart failure * current cardiogenic shock * unstable clinical condition * known cardiomyopathy (ef \< 30%) * creatinine \>1.5 mg/dl * definite allergy to iodinated contrast media * current participation in an investigational drug or device research study * hr \> 65 and contraindications to the administration of beta blockers exclusion criteria assessed during catheterization procedure * pci of native coronary vessel not performed * left main stenosis \> 50% * any vessel contraindicated for ivus imaging * any lesion contraindicated for ivus imaging * inability to pass ivus catheter * pci of bifurcation lesion

Keywords: plaque characteristics dsct ivus
pge2 levels in patient treated with nsaids

Conditions: Ocular Inflammation

Summary: the aim of this study is to determine vitreous levels of nonsteroidal antinflammatory drugs (nsaids) and prostaglandine2 (pge2) in eyes scheduled for vitrectomy. all patients received the study drugs for 3 days before surgery. 0.5 to 1.0 ml of undiluted vitreous was removed using the vitreous cutter positioned in the midvitreous cavity. samples were immediately frozen and stored at -80°c until analysis. sample analyses were performed using an high-performance liquid chromatography system. the lower limit of quantitation was 0.8 ng/ml. pge2 levels were analyzed using the prostaglandin e2 monoclonal eia kit (cayman chemical company) according to the manufacturer's instructions.


Eligibility criteria:
inclusion criteria: * epiretinal membrane or full thickness macular hole scheduled for vitrectomy exclusion criteria: * vitreous hemorrhage * diabetes * glaucoma * concurrent retinovascular disease * previous ocular inflammation * previous ocular surgery * history of ocular trauma * previuos intravitreal injections * concomitant intake of topical or systemic nsaids or corticosteroid therapy

Keywords: vitreoretinal surgery epiretinal membrane macular hole non steroidal antinflammatory drugs prostaglandin e2
ischaemic preconditioning in non cardiac surgery

Conditions: Myocardial Ischemia; Surgery

Summary: several randomized trials suggested a cardioprotective beneficial effect (eg reduction in cardiac troponin release) of remote ischemic preconditioning in cardiac surgery. remote ischemic preconditioning by brief episodes of ischemia and reperfusion in a remote organ or vascular territory provides protection from injury by myocardial ischemia and reperfusion. in the translation of remote ischemic preconditioning from bench to bedside, the first proof of principle and small randomized controlled trials have shown a decreased release of myocardial biomarkers after aortic, congenital cardiac, adult valve and coronary artery by-pass graft surgery. this reduction in cardiac biomarkers release translated into better survival in a recent randomized trial performed in cardiac surgery. no clinical trial on remote ischemic preconditioning in non-cardiac surgery setting has been performed so far. the investigators study wants to test, for the first time, the hypothesis that remote ischaemic preconditioning is effective in reducing cardiac damage in high risk patients undergoing non-cardiac surgery. remote ischaemic preconditioning will be achieved by inflation of a blood-pressure cuff to 200 mm hg to the upper arm for 5 minutes, followed by 5 minutes reperfusion while the cuff will be deflated. general anesthesia will be induced and maintained without using propofol in both groups. cardiac troponin will be used as marker of cardiac damage. if the results of a reduction in postoperative cardiac troponin release and perioperative cardiac ischaemic events will be confirmed in a non-cardiac surgery setting, the investigators could improve a strategy to prevent perioperative cardiac complication easy to apply, safe and low cost.


Eligibility criteria:
inclusion criteria: * written informed consent * intermedial and high risk non cardiac surgery * general anesthesia * ongoing or recently suspended antiplatelet therapy exclusion criteria: * pregnancy * planned locoregional anesthesia without general anesthesia * unstable or ongoing angina * recent (\< 1 month) or ongoing acute myocardial infarction * inclusion in other randomised controlled studies in the previous 30 days * peripheral vascular disease affecting the upper limbs * cardiac surgery

Keywords: remote ischemic preconditioning non cardiac surgery myocardial ischemia
probiotics on resistant bacteria colonization in preterm receiving antibiotics

Conditions: Infant, Premature, Diseases

Summary: in this study, the investigators investigated the effect of probiotic use on colonization of resistant microorganisms in newborn preterm infants receiving antibiotics. this study of the use of probiotics in preterm neonates in neonatal intensive care units expect to prevent colonization by resistant microorganisms.

the gut which is sterile in newborn preterm infants begins to colonize with birth. factors such as developmental immaturity of the immune system, encountering with the flora of neonatal intensive care unit, exposure to diagnostic and therapeutic interventional procedures, use of antibiotics, delay of enteral feeding may poorly affect the development of natural and mucosal immunity of intestine in newborns preterm during postnatal period. exposure to these factors, newborn preterm infants' life threatens especially to change the development of the normal intestinal flora and intestinal immunity. many randomized controlled studies reported that probiotics reduce intestinal inflammatory process and prevent colonization with pathogenic microorganisms of the intestines . in this study, the investigators investigated the effect of probiotic use on colonization of resistant microorganisms in newborn preterm infants receiving antibiotics.

Eligibility criteria:
inclusion criteria: * the study were included ≤36 weeks gestational age newborn preterm infants requiring antibiotic treatment and/or prophylaxis. exclusion criteria: * newborn preterm infants who are congenital anomalies and not require antibiotic therapy and undergoing intestinal operation were excluded from the study.

Keywords: newborn, preterm, probiotic, resistant microorganisms
new predictive marker for pancreatic cancer using ca19-9 and fecal elastase

Conditions: Paancreatic Cancer

Summary: background carbohydrate antigen 19-9 (ca19-9) is used as a marker to predict recurrence and survival of patients with pancreatic cancer(pdac). recently, fecal elastase-1(fe-1), a marker of pancreatic exocrine function, has been shown to correlate with prognosis in patients with pdac. however, there have been no studies that have predicted prognosis by combining these two factors. in this study, investigators developed a predictive strategy for prognosis of pdac using data on preoperative ca19-9 and fe-1 levels.6 methods the clinical data of patients with resectable pancreatic cancer from two hospitals were analyzed. the cut-off points of preoperative ca19-9 and fe-1 levels were extracted from the youden index and previous studies (385 u/ml and 100 µg/g stool, respectively). cox proportional hazard models were used to investigate the association between preoperative tumor marker levels and survival (3-overall survival and 1-year recurrence free survival) after surgery.


Eligibility criteria:
inclusion criteria: * investigators conducted a retrospective study using data from 857 patients with pancreatic cancer enrolled in two hospitals in the republic of korea (179 from gangnam severance hospital and 678 from seoul national university hospital) from january 5, 2010 to december 31, 2019. exclusion criteria: * investigators excluded patients without information about preoperative tumor marker levels (n = 45), those who received neoadjuvant (n = 169), those with preoperative ca19-9 levels \< 9.0 \[lewis antibody-negative patients\] (n = 98), those with missing covariates (n = 3) and r2 resection (n = 6).
a new 360° dual-task based protocol for the pre-clinical in-hospital and at-home rehabilitation of elderly: dual-rehab

Conditions: Cognitive Decline

Summary: the main objective of this project is two-fold 1. to develop a dual-task training exploiting the potentiality of the 360° technology in terms of interactivity and ecological validity 2. to investigate its efficacy in improving the cognitive functioning in a randomized clinical trial for 2 different populations: subjects with subjective memory complaints and mild cognitive impairment. specifically, participants will follow an integrated training including 2 phases: 1)in-hospital rehabilitation, where subjects will be provided sessions of the training in immersive modality; 2)at-home rehabilitation, where older adults will be asked to perform at home the non-immersive version of the training using a tablet. expected outcome is an improvement in cognitive functioning (assessed with a complete neuropsychological battery) after the training, thus advancing literature about non-pharmacological interventions in the preclinical stages of dementia along with innovative technical instruments.


Eligibility criteria:
inclusion criteria (group of smc): * \> 65 years old * self-reported memory complaints * score on mini-mental state examination greater than or equal to 27/30 (normal range) exclusion criteria: * no evidence of objective impairments on the neuropsychological testing, scores on the clinical dementia rating \< 0.5 inclusion criteria (group of mci): * \> 65 years old * a self-reported (or reported by a caregiver) cognitive decline * an objective impairment on the neuropsychological testing * scores on the clinical dementia rating \< 0.5. exclusion criteria: * no dementia
medical treatment alone versus varicocelectomy versus varicocelectomy and medical treatment

Conditions: Teratozoospermia

Summary: a varicocele is defined as an abnormal venous dilatation and/or tortuosity of the pampiniform plexus in the scrotum. although varicoceles are almost always and more common on the left side, up to 50% of the men with varicocele, have bilateral varicoceles. varicocele has a negative impact on spermatogenesis, testicular volume, standard semen parameters, and fertilization, implantation, and embryo outcomes.

varicocelectomy remains the first-line treatment option in infertile men with palpable varicocele and abnormal semen parameters, with the microsurgical subinguinal approach conveying the greatest success rate and fewest complications. the empirical use of antioxidant supplement may confer some benefits in men to reduce oxidative damage. medical management, including antioxidants, could offer a potential solution with lower risks given the increasing evidence suggesting the role of oxidative stress in varicocele-induced infertility. physical examination of the scrotum remains the most commonly used technique to diagnose varicoceles. palpation of the scrotum is best performed in a relaxed patient in standing position, in a warm room and carried out by a well-trained physician. surgical treatment of varicocele has a significant effect on semen parameters, so it is considered the 'gold standard' treatment for subfertile males with palpable varicoceles associated with abnormal semen analysis.

Eligibility criteria:
inclusion criteria: * sub-fertile men with clinically palpable varicoceles ( unilateral or bilateral ). * men with teratozoospermia. exclusion criteria: * recurrent varicoceles. * significant medical diseases as: hepatic insufficiency. * hypersensitivity to the drugs. * female factor of infertility.
evaluation of the venous thrombotic biological profile of different pcos phenotypes: french cross-sectional study

Conditions: Polycystic Ovary Syndrome

Summary: polycystic ovary syndrome (pcos) is the most common endocrine disorder of women of childbearing age. pcos can be individualized into several phenotypes, taking into account in particular the presence of hyperandrogenism, insulin resistance and bmi. hyperandrogenism and insulin resistance appear to be important factors in the development of cardiovascular cardiovascular disease. in addition, patients frequently use anti-androgenic and/or contraceptive treatments contraceptives, such as combined hormonal contraception (chc), the use of which is associated with an increased cardiovascular and thrombo and venous thrombosis (vte). a meta-analysis published in 2020 by gariani et al. based on three large studies, estimated the risk of vte in women with pcos after adjustment for obesity and hormone therapy. this risk was significantly higher compared with women without pcos (pooled or 1.89, ci95% 1.60-2.24). no study has looked specifically investigated the risk of vte according to different pcos phenotypes. such data would be very useful in clinical practice, as it would enable monitoring, contraceptive treatment and anti-androgenic anti-androgen treatment according to the pcos phenotype, while limiting risks. assessing the differences pcos phenotypes is limited by the large sample size required. required. vte is a rare event in women of childbearing age, and the number of pcos phenotypes is high. pcos phenotypes. intermediate markers of vte risk are used in these situations. these markers are thrombin generation tests (notably etp) and their sensitivity to activated protein c (napcsr) and thrombomodulin (ntmsr), as well as sex-hormone binding globulin (shbg).


Eligibility criteria:
inclusion criteria: * be between 18 and 35 years of age at the time of inclusion; * able to give non-opposition * strong suspicion of pcos according to 2023 recommendations * have stopped hormonal contraception for at least 3 months or insulin-sensitizing treatment for at least 3 months. * fasting for at least 12 hours. * be affiliated to a health insurance scheme. * french-speaking exclusion criteria: * already included in a type 1 interventional research protocol (riph1). * be under guardianship or curatorship * deprived of liberty * under court protection * pregnant (positive urine or blood pregnancy test), or within 3 months of post-partum or post abortum, or breastfeeding (or within 3 months of weaning) * using hormonal contraception or insulin-sensitizing therapy (a wash-out of at least 3 months before inclusion). * have a personal history of vte or known thrombophilia. * current anticoagulant or antiaggregant treatment or treatment stopped less than one month before inclusion. * have a severe personal medical history in the previous 6 weeks (fracture, infection, hospitalization, surgery, cardiovascular event, cancer).
effect of an optimal heart team protocol on decision-making stability

Conditions: Coronary Artery Disease

Summary: this study is aimed to evaluate the effect of the optimal heart team implementation protocol on the stability of decision-making for patients with complex coronary artery disease.

current guidelines recommend a heart team in the decision making for patients with complex coronary artery disease (cad). previous study reported that the agreement between heart teams for revascularization decision-making in complex cad patients was moderate. potential factors associated with decision discrepancies were summarized in several aspects and a detailed heart team implementation protocol was generated and further validation is needed. this study is designed to evaluate the effect of the optimal heart team implementation protocol on the stability of decision-making for patients with complex coronary artery disease.

Eligibility criteria:
eligibility criteria for patients: inclusion criteria: patients with stable cad according to the national cardiovascular data registry (ncdr) cathpci criteria (stable angina, no or silent myocardial ischemia) and angiographically confirmed 3-vessel disease or left main disease. exclusion criteria: 1. prior percutaneous coronary intervention (pci) or coronary artery bypass grafting (cabg); 2. cardiac troponin i (ctni) greater than the local laboratory upper limit of normal or recent myocardial infarction with ctni levels still elevated; 3. concomitant severe valvular disease, macrovascular disease, or huge ventricular aneurysm requiring surgery; 4. concomitant atrial fibrillation or severe arrhythmia eligibility criteria for specialists: inclusion criteria for interventional cardiologists: 1. annual pci volume ≥200 2. annual left main pci volume ≥25 3. capable of chronic total occlusion(cto) pci 4. clinical researcher experience in coronary revascularization 5. proficient in clinical guidelines inclusion criteria for cardiac surgeons: 1. cabg total volume ≥200 2. proficient in both on-pump and off-pump cabg 3. clinical researcher experience in coronary revascularization 4. proficient in clinical guidelines inclusion criteria for non-interventional cardiologists: 1) proficient in clinical guidelines

Keywords: heart team protocol coronary artery disease decision-making agreement
innovative and transdisciplinary observation program for the quality of life of health students

Conditions: Healthy

Summary: scientific context: students' quality of life reflects the general health of students, in connection with the studies themselves, but also with physical, biological, social, cultural, and psychological determinants. indeed, students are young adults exposed to a complex period composed of transitions in different spheres of their life: housing, domestic tasks, social learning, lifestyle choices, etc. in addition to this, students in medical and health sciences have to face with stress due to a demanding training and exposure to the hospital world. according to the haute autorité de santé (has), health professionals in activity or in training are identified as a "population at risk historically identified." the studies on stress and psychological disorders, in medical students, are considerably documented on the international level and the incidence of various psychic problems (depressive state, suicidal ideas ...) and behavioural (food behaviours, addictive behaviours ...) has been shown to be predominant in this population. however, no studies have been conducted on aspects like self-esteem, self-efficacy and extracurricular activities. in this sense, it may be interesting to match quality of life of health students in lyon compared to the results of the other studies carried out in france, and to have a global approach of the factors influencing quality of life, with identification of factors that are potentially harmful, but also beneficial to the global health. this study will also compare the results according to the different health sectors such as medicine, pharmacy, maieutic, odontology, and sciences of rehabilitation. research hypothesis: the study hypothesis is that description of the quality of life and, self-efficacy, self-esteem, nutrition, anxiety, physical activity, sleep quality, and addiction parameters in health student will better characterize student's issues in order to propose an appropriate intervention to improve their global health. the study is an observational, cross sectional and monocentric study conducted among the population of students of the lyon 1 university in the health science field on a 9 months period.


Eligibility criteria:
inclusion criteria: * adult (\> 18 years) * enrolled in 3rd year of health study (medicine, pharmacy, institute of rehabilitation sciences and techniques, odontology, maieutic) at the ucbl * participation at the required medical consultation at the college health department of ucbl exclusion criteria: * lack of comprehension of the french language * implementation of protective measures * erasmus program
shifting away from pain: neurocognitive approach to explain and predict recovery following whiplash injury

Conditions: Whiplash Injuries

Summary: around half of the patients with neck pain after trauma (whiplash) will develop chronic pain. understanding the transition from acute to chronic pain after whiplash is a priority since will help to identify those which patients are likely to fully recover and who do not. in the last years, there have been a call for an investigation of new biomarkers; particularly in brain structure and function. alterations in the structure of the brain (gray matter, white matter and cortical thickness) as well as the brain function have been found in people with chronic wad; which are also correlated with pain, disability and symptoms of central sensitization such as hyperalgesia. previous research has found structural and functional brain differences between people who develop chronic low back pain compared to those who recovered; but research in this vein is still lacking in people with whiplash. consequently, this study aims to examine the neural correlates of recovery following whiplash injury.

this study aims to investigate whether or not there are differences in brain structure and function between people who recover after whiplash and those who do not. thus, patients with acute neck pain after whiplash will be recruited. also, a pain-free age- and sex-matched control group will be recruited for comparison. a longitudinal prospective study will be conducted with two follow-up measurements (3 and 6 months). all measurements will take place at university hospital of ghent (uz gent), ghent (belgium). mri measures will be taken at baseline (\<4 weeks after the accident) and 6-months follow-up. the 3-months follow-up will only consist of the assessment of the online questionnaires; so, patients will not be required to come to uz gent.

Eligibility criteria:
whiplash patients inclusion criteria: * neck pain within 4 weeks after the trauma * native dutch speaker * refraining from consuming caffeine, alcohol and nicotine in the hour before the mri scans in both measurement times exclusion criteria: * neuropathic pain * being pregnant * a history of a chronic pain syndrome * chronic fatigue syndrome * fibromyalgia * cardiovascular disorders * epilepsy * endocrinological disorders * rheumatic disorders * psychiatric disorders * history of neck surgery * loss of consciousness during/after the whiplash trauma * mri incompatible health condition (e.g., pacemaker, metal prosthetic devices) * claustrophobia. healthy volunteers: (matched for age and gender). additional exclusion criteria include for healthy volunteers * a history of a chronic pain syndrome * a pain condition in the last six months for which treatment was sought

Keywords: whiplash chronic pain neuroimaging