Kornimate/medical-research-clean huggingface dataset:
cancer end of life evaluation

Conditions: Advanced Cancer

Summary: the aim of this study is to culturally adapt and to validate quality of life tools dedicated to the end of life for french cancer patients.

french clinical research in palliative care is confronted with a lack of tools allowing to estimate in a standardized way a patient related outcome. scales used today are not specifically adapted to quality of life (qol) at the end of life patient evaluation. so all the relative dimensions to this disease stage are not estimated. what establishes a brake in the improvement of a quality support. the dimensions of pain, psychological distress, fatigue, decrease of the autonomy are essential points estimated in "classic" questionnaires and frequently used at the palliative disease stage. however the end of life also recovers the domains of the spirituality, oneself's completion, relationship. these elements are essential to dread better qol at end of life, but are not or do not little approach on the french questionnaires. the missoula-vitas quality of life index is a questionnaire developed by byock, merriman and kinzbrunner and specifically designed for palliative situations \[i. byock, 1998\]. this qol tool provides an exhaustive assessment of important dimensions in this setting. the short version is composed of 15 items and asks patients to evaluate 5 dimensions: symptoms, function, interpersonal relationships, well-being and transcendence \[i. byock, 1998\]. another tool, the qual-e, is longer with 25 items concerning 5 domains: life completion, relations with the health care system, preparation for end of life, symptom severity and affective social support \[ke. steinhauser, 2002\]. however, these qol tools have not been translated and adapted to french. another concern is that the lack of specificity for cancer patients. the first step to improve evaluation of how french patients feel about this phase of their disease is to translate these specific end of life qol tools. assessing qol at the end of life with dedicated tools could help to compare therapeutic strategies and could result in improvements in palliative care.

Eligibility criteria:
inclusion criteria: * palliative advanced cancer patient (palliative chemotherapy, analgesic radiotherapy, surgery of comfort accepted). * all cancer locations and cancer type * patient having the knowledge of their palliative disease stage. * patient follow-up at least once a month by a palliative caregiver. * age \> or = 18 years. * dated and signed consent. * ps \> or = 2 * life expectation \> or = 1 month. exclusion criteria: * psychiatric disease or cognitive disorders disrupting the trial understanding and the enlightened and voluntary consent character. * patient who can not submit itself to the formal follow-up for psychological, social, family or geographical reasons

Keywords: quality of life cancer end of life palliative setting
nurses' level of knowledge on skin tears: a cross-sectional study

Conditions: Nurse's Role; Wound; Knowledge, Attitudes, Practice

Summary: skin tears (st) are one of the skin integrity problems encountered in healthcare settings with rates equal to or greater than pressure injuries. however, the importance of this problem has been emphasized in the literature in recent years. this study was conducted to determine the knowledge level of nurses about st.

the population of the study consisted of all nurses working in acute care hospitals in turkey. the sample size of the study was calculated as 384 nurses. the data of the study were collected in the form of online and paper-based surveys (an introductory information form and the skin tear knowledge assessment instrumen)

Eligibility criteria:
inclusion criteria: * were employed as a nurse for at least 1 year * cared for patients aged 65 and over * agreed to participate in the study exclusion criteria: • nurses who filled in the data collection tools incompletely
extended long-term safety study of kw-6500

Conditions: Parkinson's Disease

Summary: this is a extended long-term safety study in parkinson's disease patients who have motor response complications on levodopa therapy and completed 12 weeks administrations of kw-6500 in 6500-004 study. the safety and efficacy of long-term subcutaneous self-injections of kw-6500 are evaluated.


Eligibility criteria:
inclusion criteria: * patients who have given written informed consent * patients who have completed the 6500-004 study
venous thromboembolism risk profiles in chinese hospitalized patients (verse study)

Conditions: Venous Thromboembolism

Summary: venous thromboembolism (vte) is a complex multifactorial disease, mainly manifested by deep vein thrombosis (dvt) and pulmonary embolism (pe). vte events increase the length of hospitalization and treatment costs and seriously affect the quality of life of patients, so it is increasingly appreciated to identify high-risk patients with vte and take preventive measures. the padua prediction score (pps) and caprini risk assessment model (ram) are widely used in clinical practice as common risk assessment scales in medical and surgical departments, respectively. and d-dimer levels have been considered as a well indicator to rule out acute vte. previous epidemiological studies on vte have found the risk of vte is significantly higher in hospitalized patients than in the general population and the prophylaxis decisions vary among countries, hospitals and departments, indicating current in-hospital vte prevention strategies are far from optimal and it's imperative to regionalized control of vte. therefore, a single-institution-based risk profile study of in-hospital vte patients is designed to explore current situation of vte occurrence and predictive efficacy of widely used risk assessment models as well as d-dimer in one of the general hospitals in beijing, china.

in this study, the investigators recruited adult inpatients attending tsinghua chang gung hospital in beijing from june 2018 to april 2020, screened for patients with a hospital stay over 3 days and new-onset of vte during hospital stay, and identified the in-hospital vte patients after excluding patients who presented for dvt and/or pe. similarly, negative patients were selected by not having a vte during hospital stay. the diagnosis of vte was confirmed as the occurrence of a critical value alert during hospitalization, which was predefined as ultrasound/radiology report of dvt or/and pe. data was collected from the teach database of beijing tsinghua chang gung hospital affiliated with tsinghua university. patients baseline characteristics were extracted from database. vte risk assessment was conducted with either caprini risk assessment model (surgical patients) or padua prediction score (medical patients). the evaluation was started upon admission and regularly repeated depending on the patient's condition. the last evaluation was conducted before discharge. the d-dimer values during hospitalization were also collected. the rate of in-hospital vte, distributions of in-hospital vte patients and the receiver operating characteristic curves were analyzed.

Eligibility criteria:
inclusion criteria: 1. age 18 and over, male or female 2. inpatients with a hospital stay over 3 days 3. with or without new-onset of vte during their stay exclusion criteria: 1. patients who presented for dvt and/or pe 2. patients who were admitted in emergency department

Keywords: vte china caprini risk assessment model padua prediction score risk profiles
pre-hospital cooling in cardiac arrest patients

Conditions: Cardiac Arrest

Summary: type of study: pilot prospective nonrandomized feasibility clinical study. aim of the study: to assess the feasibility of pre-hospital therapeutic mild hypothermia in patients successfully resuscitated from out-of-hospital cardiac arrest in the setting of prehospital and hospital care in czech republic. evaluated hypothesis: pre-hospital initiation of therapeutic mild hypothermia by rapid administration of intravenous bolus of cold crystalloids is simple, safe, effective and is a feasible procedure to significantly decrease body core temperature during patient's transport to the hospital in czech republic. the study is observational and does not evaluate any new drug, therapeutic procedure or diagnostic procedure. it is evaluating a known therapeutic procedure, therapeutic mild hypothermia, induced by known technique, cold crystalloid infusion, widely accepted in hospital-related postresuscitative care. however, even its prehospital usage has been published.


Eligibility criteria:
inclusion criteria: * patients resuscitated from out-of-hospital cardiac arrest * remaining comatose and requiring mechanical ventilation exclusion criteria: * cardiac arrest of traumatic etiology * patient conscious after short cardiopulmonary resuscitation * coma of other origin than cardiac arrest (e.g., epileptic paroxysm, intoxication etc.) * severe acute heart failure * accidental hypothermia below 30°c * bradycardia requiring transcutaneous cardiac pacing * status do not resuscitate or do not intubate * severe circulatory shock * severe life threatening cardiac arrhythmias * severe and life threatening bleeding * severe sepsis * any common opinion of intervening team of unfitness of induction of therapeutic mild hypothermia

Keywords: cardiac arrest therapeutic hypothermia postresuscitative disease
effect of loading of midazolam or dexmedetomidine on hemodynamics

Conditions: Knee Injuries

Summary: loading dose of dexmedetomidine is related hemodynamic instability such as bradycardia and hypertension.

the investigators hypothesized substitution of loading of dexmedetomidine for midazolam could reduce hemodynamic instability during spinal anesthesia for knee arthroscopy.

Eligibility criteria:
inclusion criteria: * patients who were planned to undergo knee arthroscopy under spinal anesthesia exclusion criteria: * age \< 20 years * underlying heart, liver or kidney disease * hypersensitivity to midazolam or dexmedetomidine
supporting the recovery needs of patients following intensive care

Conditions: Post Intensive Care Unit Syndrome; Post Intensive Care Syndrome; ICU Acquired Weakness; Intensive Care Unit Syndrome; Intensive Care Unit Acquired Weakness

Summary: recovery for intensive care survivors is limited by ongoing problems with walking, strength, fatigue, mental distress and cognitive morbidity known as 'post intensive care syndrome'. there has been increasing interest in ways that clinicians can support patients in their post icu recovery. the investigators are undertaking a co design approach to informing the design of a recovery pathway for patients who have been admitted to the intensive care to support them in their return to home, family and working responsibilities.

this project will aim to involve \~ 20 past icu patient/family members and \~20 health professionals to participate in a co-design approach to examine the recovery needs and resources that are required to support patients after leaving hospital. using an experience based co design methodology three 2-hour workshops will be run with the first workshop involving patients/family members, the second involving healthcare professionals to separately gain thoughts and perspectives, and then the final workshop which will be combined to identify and problem solve priority resources and solutions.

Eligibility criteria:
inclusion criteria: * hospitalized adults, aged 18 years or over * admitted to the icu requiring invasive mechanical ventilation for \> 48 hours and remain in the icu for a minimum of four days * living at home before the current admission (not in a facility and/or no fixed abode) exclusion criteria: * non-english speaking (insufficient english language skills to read and understand questionnaires and patient information consent form) * pre-existing documented cognitive impairment * spinal cord injury or other primary neuromuscular disease * new lower limb fracture with altered weight bearing status * expected survival \< 3 months according to the treating medical team * active substance abuse or psychosis * lack of access to telephone / computer or inability to use these resources independently (which would impact on ability to complete the intervention) * pregnancy * suicidality * incarcerated * cardiac surgery within this icu admission (as these patients routinely receive a standard outpatient rehabilitation through cardiac rehabilitation) * poor premorbid mobility defined as \< 10 metres ambulation +/- gait aid independently
a clinical study trial of phenlarmide in china

Conditions: Parkinson Disease

Summary: 1. to evaluate the tolerance and safety of fla tablets in healthy volunteers. 2. to evaluate the pharmacokinetics of fla tablets in healthy volunteers. 3. provide basis for dosage setting for follow-up clinical research.


Eligibility criteria:
inclusion criteria: * 1)18-65 years old (including upper and lower limits); * 2)men and women are not limited; * 3)men weigh more than 50 kg, women weigh more than 45 kg, bmi 19-28 kg/m2 (including upper and lower limits); * 4)understand and sign the informed consent, understand the research process and requirements, and volunteer to participate in this study. exclusion criteria: * 1)there is a history of heart, liver, kidney, respiratory, digestive tract, nervous system, endocrine, immune or hematological diseases judged by researchers as having clinical significance; * 2)there are abnormalities in vital signs, general physical examination, laboratory examination and ecg examination, which are judged to be of clinical significance by researchers; * 3)any drug was taken within two weeks before the study was administered, and the researchers believe that this condition may affect the evaluation results of the study; * 4)there is a significant history of drug allergy or hypersensitivity in food that researchers have identified as clinically significant; * 5)the positive results of serological tests (hbsag, anti-hcv, anti-hiv or tp-ab) were found at the time of screening; * 6)one year before the study was administered, some researchers believed that alcohol or drug abuse history might affect the results of this study, or that alcohol breath test or urine drug screening test were positive during screening; * 7)those who had smoking history within three months before the first administration or who had positive urinary cotinine test in screening stage; * 8)those who participated in any clinical trial within 3 months before administration; * 9)those who donated blood more than 400 ml or 2 units within 3 months before administration; * 10)do not agree to avoid the use of tobacco, alcohol or caffeine-containing beverages within 24 hours before and during the trial, or to avoid vigorous exercise, or to avoid other factors affecting drug absorption, distribution, metabolism and excretion; * 11)pregnant or lactating women, or those with positive serum hcg test before administration, or those who are unable or unwilling to adopt contraceptive measures approved by the researchers during the study period and within three months after the end of the study, as directed by the researchers; * 12)researchers do not consider it suitable for participants in this clinical study.

Keywords: tolerance safety pharmacokinetic characteristics
continuous positive airway pressure on tuberculosis pleural effusion

Conditions: Tuberculosis; Pleural Effusion

Summary: tuberculosis (tb) remains as an important public health problem worldwide. pleural tuberculosis is the most prevalent form of extrapulmonary presentation in immunocompetent patients. the volume of effusion in the pleural space of patients with pleural tb may cause complications like restrictive ventilator lung functional disturb and/or pleural thickening. the respiratory physiotherapy can be adjuvant on treatment of pleural effusion tuberculosis throughout of various treatment technique. the continuous positive airway pressure (cpap) is utilized in various pathologic, this improves lung mechanics by recruiting atelectatic alveoli, improving pulmonary compliance, and reducing the work of breathing. the aim of this study is to determine the effect of cpap on fluid absorption among patients with pleural effusion due tuberculosis.

this randomized and controlled trial compared the reduction of the pleural effusion volume of the group of patients using the anti-tb standard regimen to that using the anti-tb standard regimen and adjuvant treatment of physical therapy during four weeks. * control group: the patients received rifampicin, isoniazid and pyrazinamide daily(anti-tb standard regimen) * interventional group: the patients received anti-tb standard regime and continuous positive airway pressure (cpap) 3 times a week for 30 minutes with positive expiratory end pressure of 10 cmh2o. evaluation of the pleural effusion size: a helicoidal thoracic computed tomography (ct) was carried out in all patients enrolled. the valuation was conducted by two radiologists blinded for the treatment used, specifically trained for the purpose of the study.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of pleural tuberculosis. * patients 18 years of age and older. exclusion criteria: * be under previous treatment of respiratory physiotherapy. * irregular use or abandonment of the anti-tb standard regimen. * to fail one or more physiotherapy section. * to fail one or more radiological evaluation.

Keywords: cpap tuberculosis pleural effusion physiotherapy
prediction of the severity of female sui by measuring new static and dynamic ultrasound parameters of the urethra

Conditions: Incontinence, Urinary

Summary: this study aims to evaluate the correlation of the ultrasonic functional length of the urethra and the incontinence urinary disorder (iud). the goal is to predict the severity of the iu by measuring new static and dynamic ultrasound parameters of the urethra.

the urinary incontinence is a disorder which affects 25 to 45% of women. nowadays, the role of urethral tissue in iud is not explored although well viewed in perineal ultrasound. our actual knowledge demonstrates that urodynamic ultrasound is reliable to establish the bladder neck mobility. and the posterior urethral wall mobility was often associated to the stress urinary incontinence. two elements appeared to indicate the elasticity of the urethral environment: functional length urethral variation and urethral closure angle variation during valsalva manoeuvres compared to rest. this study aims to evaluate the correlation of the ultrasonic functional length of the urethra and the incontinence urinary disorder for the purpose to predict the severity of this syndrome.

Eligibility criteria:
inclusion criteria: * all patients aged over 18 years addressed to pelvic ultrasound exclusion criteria: * pregnant * post-partum (under 6 month of childbirth) * operated for a genitourinary prolapse or/and urinary incontinence * utero vaginal symptomatic prolapse * overactive bladder ± ui by * dysuria * severe deep pelvic endometriosis * respiratory failure (unable to perform the valsalva manoeuvres) * history of pelvic cancer * unable to understand the information communicated
nimotuzumab for recurrent nasopharyngeal carcinoma

Conditions: Recurrent Nasopharyngeal Carcinoma

Summary: the study assessed the clinical efficacy, and safety of the combination of nimotuzumab administered concomitantly with intensity modulated radiation therapy(imrt) in patients with recurrent nasopharyngeal cancer.

the clinical efficacy of nimotuzumab combined with radiotherapy has been shown in advanced nasopharyngeal cancer, which was significantly higher than radiotherapy alone. the efficacy of radiotherapy combined with nimotuzumab has not been confirmed in recurrent nasopharyngeal cancer.in this study, phase ii clinical trials were performed. the patients were treated with nimotuzumab which were used concurrently with imrt. the efficacy and toxicity will be assessed.

Eligibility criteria:
inclusion criteria: 1. patients with recurrent tumor in nasopharynx with or without relapse cervical lymph nodes more than 6 months after initial radical treatment. 2. recurrent nasopharyngeal cancer was confirmed by pathology, marginal recurrence can be diagnosed by imaging examinations. 3. age 18-70. 4. at least one of the tumor lesions measurable. 5. functional status: ps (ecog) \> 0-1. 6. normal bone marrow function: white blood cell count \> 4×109/l, hemoglobin \>90g/l, and platelet count \>100×109/l. 7. normal hepatic and renal function: alanine tminotransferase (alt)/aspartate aminotransferase (ast) \< 2.5 times the upper limit of normal (uln), while total bilirubin (t-bil) \< 1.5 x uln and serum creatinine \< 1.5 x uln. 8. life expectancy of more than 6 months. 9. all the patients signed the informed consent. 10. follow up regularly and comply with test requirements. exclusion criteria: 1. patients with recurrent cervical lymph nodes alone. 2. evidence of distant metastasis 3. the relapse tumor has been treated with chemotherapy, radiotherapy, surgery, immunotherapy and other anti-tumor therapy. 4. creatinine clearance \< 30ml/min 5. has received epidermal growth factor targeting therapy. 6. second malignancy within 5 years(except of non-melanoma skin cancer or carcinoma in situ of cervix). 7. serious complications, such as uncontrolled hypertension, coronary heart disease, diabetes, heart failure, etc. 8. active systemic infection. 9. history of serious lung or heart disease. 10. drug or alcohol addiction. 11. persons without capacity for civil conduct or persons with limited capacity for civil conduct. 12. the patient has physical or mental disorders and is believed to be unable to fully or fully understand the possible complications of the study. 13. to receive chronic systemic immunotherapy or hormone therapy other than this study. 14. women who are pregnant or breast feeding 15. participation in other drugs clinical trials within 1 month.

Keywords: nimotuzumab imrt radiation recurrent nasopharyngeal carcinoma