Kornimate/medical-research-clean huggingface dataset:
the effects of gabapentin and ramosetron on postoperative nausea and vomiting in laparoscopic gynecological surgery

Conditions: Postoperative Nausea and Vomiting

Summary: this study was designed to compare the effects of gabapentin and ramosetron on ponv in patients undergoing laparoscopic gynecologic surgery.

postoperative nausea and vomiting (ponv) in the postanesthesia care unit is a common occurrence after general anesthesia. and laparoscopic gynecological surgery is associated with a high incidence of ponv. several antiemetic agents such as dopaminergic, histaminic and 5-ht3 antagonist (including ondansetron, ramosetron, granisetron) have been used to prevent ponv. gabapentin, anti-convulsant, has been shown to decrease ponv, as well as chemotherapy induced nausea and vomiting in recent studies, although the exact mechanism against ponv is not known. the purpose of this study was to compare the efficacy of gabapentin and ramosetron in preventing ponv in patients undergoing laparoscopic gynecological surgery.

Eligibility criteria:
inclusion criteria: * patients with asa physical status 1 and 2 between 20 and 65 years undergoing laparoscopic gynecological surgery with patient-controlled analgesia for postoperative pain control. exclusion criteria: * pregnant women * patients who took sedatives, antiemetics, hypnotics, analgesics, steroid, or gabapentin * patients with neurological deficits * patients with history of drug abuse and allergy of study drugs
a three month bleeding-model clinical study

Conditions: Gingivitis

Summary: the objective of the study is to evaluate the gingivitis control benefit of an established stannous fluoride containing toothpaste relative to a negative control dentifrice.


Eligibility criteria:
inclusion criteria: * be at least 18 years of age; * provide written informed consent prior to participation and be given a signed copy of the informed consent form; * be in general good health as determined by the investigator based on a review of the health history/update for participation in the trial; * have at least 20 gradable teeth; * have established gingivitis with 10-70% bleeding sites; * agree to return for scheduled visits and follow the study procedures; * agree to refrain from use of any non-study oral hygiene products for the duration of the study; * agree to delay any elective dentistry, including dental prophylaxis, until the completion of the study. exclusion criteria: * having taken medications (antibiotic, anti-inflammatory, or anti-coagulant) which could alter gingival bleeding within 4 weeks of the baseline visit; * having any oral conditions that could interfere with study compliance and/or examination procedures, such as widespread caries, soft or hard tissue tumor of the oral cavity, or advanced periodontal disease; * having known hypersensitivity to the test products; * having removable oral appliances; * having fixed facial or lingual orthodontic appliances; * self-reported pregnancy or lactation; * having any diseases or condition that might interfere with the safe participation in the study; * having an inability to undergo study procedures.
effects of deep brain stimulation in parkinson's disease

Conditions: Parkinson's Disease

Summary: the purpose of this study is to identify factors predicting good results in patients treated with deep brain stimulation for parkinson's disease. the study includes a comparison of two surgical methods used to provide this therapy.

the study will prospectively examine the effects of deep brain stimulation of the subthalamic nucleus (stn-dbs) on motor function, quality of life and cognitive function in parkinson's disease (pd) patients treated at rikshospitalet university hospital. the aim is to identify which factors that predict good treatment outcome, in order to improve patient selection of this generally highly effective, but specialized and expensive treatment. the study has several aims: 1. randomized double-blind evaluation of the impact of using single vs. multiple electrode-recordings to guide electrode placement. 2. to identify factors predicting good effect on motor function and improvements of quality of life after deep brain stimulation of the subthalamic nucleus. 3. to identify cognitive and psychiatric changes related to deep brain stimulation of the subthalamic nucleus 4. to study social functioning of patients after stn-dbs and quality of life of patient caregivers

Eligibility criteria:
inclusion criteria: * diagnosis of parkinson's disease * symptoms ≥ 5 years * severity of parkinson's disease ≥ 20 points in updrs motor scale (scale 0-108) in off medication state * marked fluctuations of motor symptoms and/or troublesome dyskinesias and/or severe tremor and/or intolerable side-effects of dopaminergic drugs * failure of medical treatment to sufficiently control symptoms * l-dopa responsive symptoms with ≥30% reduction in updrs motor score in drug on state compared to off state or severe l-dopa unresponsive tremor exclusion criteria: * previous surgery for parkinson's disease * marked axial motor symptoms unresponsive to treatment with l-dopa * dementia (mattis dementia rating scale \< 130). * patient suffering from untreated moderate or major depression or anxiety disorder * presence of other psychiatric disorder preventing necessary co-operation * brain mri showing marked atrophy or white matter changes * increased risk of bleeding * presence of medical illness with short life expectancy * other surgical contra-indications

Keywords: deep brain stimulation subthalamic nucleus
reduction of seroma and improvement of qol in breast reconstruction with tissue expander

Conditions: Safety Issues; Quality of Life

Summary: the experimental hypothesis of this randomized controlled study was to demonstrate that early drain removal in patients who underwent immediate breast reconstruction with tissue expander is a safety procedure to improving clinical outcomes and quality of life (qol). the mechanism of action underlying the proposed approach was intuitive. the early drain removal allows to: 1) avoid continuous seroma development caused by active suction of drain (stopping the circle "drain itself may perpetuate the drainage" with vacuum mechanism); 2) reduce the risks connected to "foreign body reaction" as tissue inflammation and infection; 3) improve qol reducing pain, length of hospital stay and limitations of daily activities.


Eligibility criteria:
inclusion criteria: * sns (skin nipple sparing) or ss (skin sparing) mastectomy for breast cancer and immediate positioning of breast expander (without mesh) with placement of suction drain, regardless of tnm classification exclusion criteria: * skin reducing mastectomy, reconstruction with flap, direct to implant reconstruction (with or without mesh or adm) and axillary dissection
goitres influence on voice function - the impact of surgery

Conditions: Goiter

Summary: the aim of the study is to investigate the influence benign non-toxic goitre and the surgical treatment hereof on the voice function before and 6 months following surgery.


Eligibility criteria:
inclusion criteria: * patients undergoing hemi- or total thyroidectomy for benign non-toxic goiter with pressure symptoms * the patients must be able to understand, write and read danish exclusion criteria: * previous surgery to the neck * diabetes or any neuromuscular disorders. * present or previous head and neck malignancy, including malignancy found in the surgical thyroid specimen or suspicion hereof.

Keywords: goitre thyroid disease struma
deep tissue massage on pain and comfort after cesarean

Conditions: Cesarean Section; Pain, Postoperative; Massage; Comfort; Midwifery

Summary: the aim of this study to determine the effect of deep tissue massage applied to the back on pain and comfort after cesarean section. personal information form was used as data collection form, visual analog scala was used to assess pain, and postpartum comfort questionnaire was used to assess comfort.

material and method this research was conducted between may 2019 and november 2019 in inonu university turgut ozal medical center training and research hospital. when power analysis was performed, the sample size was calculated to be at least 81 women for each group (81 experiments, 81 controls). experimental group received deep tissue massage twice at 11st and 23rd hours after cesarean section. data collection form for experimental and control groups before the first massage; visual analog scala was applied four times before and after both massages. after the second massage, both groups were re-administered. descriptive statistics and independent t-test were used for data analysis.

Eligibility criteria:
inclusion criteria: * pain severity is 45 mm or more according to the visual analogue scale (vas), * having a single and healthy newborn, * does not respond negatively to any attempt to touch like massage, * women whose tissue integrity is complete and healthy in the area to be massaged were included in the sample. exclusion criteria: * those with cesarean section with general anesthesia, * any problems diagnosed before birth and at birth (such as oligohydramnios, preeclampsia, heart disease, diabetes, placenta previa) * any complications related to the mother and baby in the postpartum period (bleeding, hypertension, babies taken to the neonatal intensive care unit, etc.), * those who received repeat doses other than routine narcotic analgesics (0.5 mg in the first 30 minutes) were not included in the study.
restoring non-emergent cardiovascular care in the peri- covid-19 era

Conditions: Corona Virus Infection

Summary: pre-procedure and short-term covid-19 testing of outpatients undergoing non-emergent invasive cardiovascular procedures


Eligibility criteria:
inclusion criteria: • outpatients undergoing non-emergent invasive cardiac diagnostic, cardiac interventional, peripheral diagnostic, peripheral interventional, structural heart interventional, electrophysiology diagnostic, ablation, or device implantation procedures exclusion criteria: * previous positive covid-19 test result * patients with symptoms concerning for covid-19, including (but not limited to): fever \> 38˚c, shortness of breath and/or cough in greater severity from baseline, sore throat, anosmia / dysgeusia, vomiting/diarrhea within 24 hours prior to procedure * emergent status including (but not limited to) acute coronary syndromes, acute limb ischemia, stroke, need of temporary pacemaker * non-outpatient status including (but not limited to) patients evaluated in the hospital, observational unit, or emergency department

Keywords: covid-19 testing outpatient procedures
coordinating access to care for people experiencing homelessness (catch-fi)

Conditions: Mental Health Disorder

Summary: coordinating access to care for the homeless (catch) initiative is a multidisciplinary brief intervention for homeless adults with mental health needs discharged from hospital in toronto, canada. the study aims to evaluate the effect of financial incentives in facilitating treatment engagement of homeless people with mental illness, as well as in improving health, health service use and housing outcomes, compared to usual catch care, over 6 months, a critical time of transition from hospital to community care.


Eligibility criteria:
inclusion criteria: * able to give informed consent * a new client of the catch team, recently admitted or readmitted * at least one contact with the catch team exclusion criteria: -
melatonin and the metabolic syndrome

Conditions: Metabolic Syndrome

Summary: this trial seeks to compare the effects of melatonin supplementation versus placebo in subjects with the metabolic syndrome.

the primary purpose of this phase ii crossover design trial is to examine the safety and efficacy of 8mg of melatonin taken one hour before bedtime compared to a placebo treatment to improve at least one of the five components associated with the metabolic syndrome.

Eligibility criteria:
inclusion criteria: 1. age 30-79 years. 2. diagnosed with metabolic syndrome according to adenosinetriphosphate-iii criteria. 3. availability for six months after enrolling in the study. exclusion criteria: 1. inability to understand informed consent and to cooperate with study procedures. 2. supplemental intake of melatonin. 3. current smoking. 4. current use of calcium channel blockers. 5. current, planned, or recent (12 months) participation in another clinical trial. 6. women who are pregnant, breast-feeding, attempting conception, or planning to attempt conception over the next 6 months. 7. presence of any of the following diagnosed health conditions: * active malignancy other than nonmelanoma skin cancer (current therapy for this malignancy,diagnosis within five years of enrollment, recurrence within five years of enrollment, or metastasis) * uncontrolled hypothyroidism or hyperthyroidism * recent (\< 1 year ago) history of heart attack, bypass surgery, angioplasty, or stroke * heart failure (new york heart association functional class 3 or 4) * on renal dialysis * immunosuppressive therapy (systemic corticosteroids, azathioprine, methotrexate, cyclophosphamide, * etc.) or an immunodeficiency syndrome * narcotic or alcohol dependence * obstructive sleep apnea (osa) , defined either by previous diagnosis (with or without use of nasal cpap), or by a score of 0.80 or higher on the map (multivariate apnea prediction), a validated screening algorithm with high positive and negative predictive value for identifying osa. 8. shift-workers.

Keywords: blood pressure glucose levels hdl levels triglyceride levels waist circumference
adhesive capsulitis and dynamic splinting

Conditions: Adhesive Capsulitis

Summary: the purpose of this study is to examine the efficacy of dynamic splinting in reducing contracture following diagnosis of adhesive capsulitis.

this randomized controlled trial will explore the efficacy of dynamic splinting in conjunction with the current standard of care as compared to standard of care alone.

Eligibility criteria:
inclusion criteria: * greater than 25% reduction in maximal external rotation plus greater than 25% reduction in at least one other plane of motion (elevation or abduction), as compared to the asymptomatic shoulder, measure supine with humerus abducted to 90º * duration from onset less than 12 months. * pain that is worsened by moving the arm in that direction exclusion criteria: * any previous shoulder surgery. * brachial plexus injuries * neurologically mediated pain and fibromatosis-like contracture * concomitant neurologic complaints or abnormalities * glenohumeral impingement or mechanical blockage * oncological process affecting the shoulder * previous total mastectomy * glenohumeral arthritis

Keywords: frozen shoulder adhesive capsulitis rom dynasplint
comparison of hearing aid fitting outcomes between self-fit and professional fit for mdhearing smart hearing aids

Conditions: Hearing Loss

Summary: hearing aids are commonly used to help people with hearing loss hear better in daily listening environments. mdhearing smart hearing aids are designed to use the mdhearing app to adjust hearing aids to each individual's hearing loss. this study intends to show whether the mdhearing smart hearing aids can be fitted by each user reliably and if each user can use the mdhearing app on their smartphone or tablet to make adjustments to achieve good aided benefit, which will be compared to those fitted by audiology professionals. this study includes three components: human factor study, self-fit study, and professional-fit study. the information obtained will be useful for both audiology professionals and people with impaired hearing.


Eligibility criteria:
inclusion criteria: * over 18 years old * at least one air conduction threshold above 15db hl. * all air conduction thresholds must be under 60db hl exclusion criteria: * signs of outer or middle ear pathology * greater than 60db hl hearing loss at any frequency.
the effect of art therapy on physical and psychological symptoms of breast cancer survivors

Conditions: Breast Cancer

Summary: art therapy is a health profession in which art making is utilized as a means of expression and communication within a therapeutic and supportive relationship \[1\]. art therapy has been shown to reduce psychological (anxiety, negative mood) and physical (pain, fatigue) symptoms which accompany many breast cancer patients and survivors \[2-7\]. qualitative studies provide an initial understanding of the mechanisms through which art therapy facilitates symptom reduction \[8\]. breast cancer patients have reported that art therapy provided them with access to emotional material otherwise inaccessible \[9\]. the goal of this study is to examine the effect of art making within a therapeutic framework on emotional awareness and acceptance.


Eligibility criteria:
inclusion criteria: adult women (over age 18), breast cancer survivors without evidence of active illness, hebrew speaking and receiving preventative hormonal therapy for at least 6 months (steady state), receiving care at the survivor's clinic of davidoff medical center exclusion criteria: a psychiatric diagnosis requiring medication, functional difficulties that affect the ability to handle art supplies, non-hebrew speaking, unwilling to answer the research questionnaires
viscosity of fibre predicts cholesterol-lowering in healthy individuals

Conditions: Lipidemia; Healthy

Summary: to investigate the role of fibre viscosity (low, medium, high) in lowering cholesterol in healthy individuals


Eligibility criteria:
inclusion criteria: -healthy individuals exclusion criteria: * regular alcohol consumption * regular smoking

Keywords: dietary fibre viscosity lipids healthy
use of parent connectors in first episode psychosis (fep)

Conditions: First Episode Psychosis (FEP)

Summary: this study proposes to adapt an evidence based peer parent navigator (ppn) intervention, called parent connectors, in which trained and supervised ppns deliver weekly telephone-based support for six to nine months to parents or caregivers of all newly enrolled youth or young adults (y/ya) in fep services. this ppn model will be used to enhance the delivery of coordinated specialty care (csc) for y/ya in new york's state program for fep, called ontrackny (otny). this research project has potential to add value to the csc model through the inclusion of a feasible, low burden intervention that may improve family participation in services and y/ya outcomes. using random assignment, this study will examine the feasibility and preliminary impact of an accelerator strategy-the inclusion of peer parent navigators or ppns-in csc teams.


Eligibility criteria:
inclusion criteria: * parents or caregivers of all newlyenrolled youth or young adults (y/ya) in fep services exclusion criteria: * na
the effects of inorganic nitrate on cardiac muscle in angina

Conditions: Chronic Stable Angina

Summary: previous studies have shown that interventions which modestly increase blood nitrite_ improve skeletal muscle function on exercise while sparing oxygen, and have been also shown to open up the blood flow during periods of oxygen deprivation. inorganic nitrate in the diet is absorbed into the bloodstream, concentrated and reduced by bacteria in the mouth to nitrite, which is then absorbed into the bloodstream. . the purpose of this study is to look at the effects of oral inorganic nitrate supplementation on clinical markers of heart ischaemia and the frequency of angina.


Eligibility criteria:
inclusion criteria: * patients aged 18 and over with chronic stable angina (≥2 months duration). inclusion criteria following screening visit: * a positive exercise ecg (1mmstd at j+0.08 seconds) on a modified bruce protocol treadmill exercise test. * a positive dobutamine stress echocardiogram, * and/or a positive myocardial perfusion scan (mpi), * and/or a positive coronary angiogram. exclusion criteria: * unable to do exercise test * women of child bearing potential * if of a racial origin at risk of glucose-6-phosphate dehydrogenase (g6pd) deficiency, g6pd will be excluded prior to inclusion in the study * resting std\>=1mm * nyha 3 or 4 hf or lvef\<45% * myocardial infarction or revascularisation within the last two months * left bundle branch block (lbbb)
role of chest ultrasound in detection of post-operative pulmonary complications after cardiothoracic surgery

Conditions: IHD; Valve Heart Disease; Surgery--Complications

Summary: * assess feasibility of detecting pulmonary complications postoperative using chest ultrasound compared to chest x-ray * measure time lag between using ultrasound and using chest x-ray to detect pulmonary complications postoperative

it is well known that cardiothoracic surgery causes different types of pulmonary complications like residual pleural effusion and pneumothorax therefore it is common that surgeons make a thoracic drainage by introducing intercostal tubes for evacuation of air and fluid from the pleural space. complications extend to involve the parenchymal pulmonary tissue causing consolidation or involve the interstitial tissue .all these complications affect the postoperative recovery. as a classical technique a daily chest x-ray is performed from first day of surgical intervention to hospital discharge to assess the amount of residual pleural effusion so drainage removal can be done or not and also assess other pulmonary complications. however, chest x-rays are costly, exposing patients and health care workers to ionizing radiation requiring patient movement with chest drains, difficult positioning of the patient to get good films, and time consuming. on the other hand, using chest ultrasound is a good alternative for chest x-ray because it is a bedside, easier, more sensitive and accurate in detection of pulmonary complications. its main advantages represented in avoiding the danger of ionizing radiations, easier device portability, low cost and a rapid learning curve. so it is easy and less time consuming to correlate between ultrasound findings and clinical data and assist in invasive procedures. hypothesis that detecting pulmonary complications postoperative using chest ultrasound is easier, more sensitive and accurate compared to chest x-ray.

Eligibility criteria:
inclusion criteria: * patients undergoing cardiothoracic surgery at assiut university hospital include cabg, valve replacement, minimal invasive cardiac surgeries, thoracic surgeries as open thoracotomy and vats surgeries and others. * age \>18yrs: 80yrs. exclusion criteria: * patients \ 80yrs. * patient refused to be enrolled in research * patient with subcutaneous emphysema