Kornimate/medical-research-clean huggingface dataset:
uscom parameters in preterm infants: reference ranges

Conditions: Very Low Birth Weight Infant; Very Preterm Maturity of Infant

Summary: the goal of this observational study is to learn about the feasibility of hemodynamic measurement by the ultrasonic cardiac output monitor (uscom) in very preterm or very-low-birth-weight infants. the main questions it aims to answer are: 1) establishing reference ranges for uscom parameters in this specific population, 2) assessing the effect of patients' characteristics and other possible confounders on uscom parameters, and 3) evaluating the short-term repeatability of the measurement. participants will receive uscom measurements on 3, 7, and 14 postnatal days.


Eligibility criteria:
inclusion criteria: * gestational age at birth below 32 weeks and/or * birth weight (bw) below 1500 g exclusion criteria: * congenital heart diseases, * hemodynamic instability requiring drugs that affect hemodynamics (e.g., inotropes)
paediatric safety study in cat-pad

Conditions: Rhinoconjunctivitis

Summary: study to assess the safety of cat-pad in cat allergic paediatric subjects


Eligibility criteria:
* inclusion criteria * male or female, aged 5-12 years. * moderate to severe rhinoconjunctivitis on exposure to cats for at least 2 years. * subjects may optionally also have gina step 1 controlled asthma. * positive skin prick test to cat hair. * cat dander specific ige ≥0.35 ku/l. * exclusion criteria * asthma falling under the gina definitions "partly controlled" and "uncontrolled" or steps 2 to 5. * fev1 \<80% of predicted. * clinically relevant abnormalities detected on physical examination. * history of severe drug allergy, severe angioedema or anaphylactic reaction to food.

Keywords: cat allergy rhinoconjunctivitis
use of facilitated stair coach in kenya

Conditions: Facilatated STAIR Coach

Summary: the specific aim of this project is to examine the feasibility of using a low cost, low intensity, mobile app-based intervention teaching emotion regulation and interpersonal skills to improve general well-being for those with probable post-traumatic stress disorder (ptsd) in kenyan clinics.

the aim of the present study is to examine the feasibility of the use of the skills training in affective and interpersonal regulation (stair; cloitre et al., 2020) coach mobile app delivered through a mobile app for individuals with probable post-traumatic stress disorder (ptsd) in kenya. this pilot study will recruit a total of 10 participants with probable ptsd. participants will complete 10 modules focused on learning skills to improve interpersonal functioning and emotion regulation. the sessions will be facilitated by a mental health worker trained in stair. participants will complete baseline (week 0), mid-treatmnet (week 5), post-treatment (week 11), one-month (week 15) and 3-month (week 23) follow-up visits.

Eligibility criteria:
inclusion criteria: * criteria 1. 18 years of age or older 2. ability to complete the study in english 3. agreed to be contacted for follow-up studies when consenting to the parent study 4. not currently enrolled in another form of psychotherapy 5. if currently prescribed medications, participants must be on a stable dosage of psychotropic medications (i.e., prescribed on stable dose for 1 month or more) 6. have a score of 33 or higher on the pcl-5 lifetime score in the parent study exclusion criteria: 1. less than 18 years of age 2. unable to complete the study in english 3. did not agree to be contacted for follow-up studies when consenting to the parent study 4. diagnosed with a psychotic disorder, unmedicated bipolar disorder, or severe substance-use disorder 5. experiencing ongoing long-term trauma as it is a contraindication for trauma focused treatment 6. experiencing acute levels of alcohol or is under the influence of an illegal substance, demonstrated by inpatient medical care for alcohol or substance abuse 7. participant is not competent to consent to the study as measured by the ubacc in the parent study 8. during parent study assessment (irb23-0211), the participant receives a pcl score less than 33 9. participant is receiving inpatient psychiatric care at the time of the study or experiencing involuntary detention

Keywords: stair stair coach post-traumatic stress disorder
study of the decrease of length of stereotactic body radiation therapy in lung cancer

Conditions: Stage IA - IB Non Small Cell Lung Cancer

Summary: purpose : non small cell lung cancer (nsclc) is among the most common cancers in the werstern world. patients with stage i have the most satisfactory outcomes. the gold standard for treatment is still surgery, but this approach has recently been challenged by hypofractionnated stereotactic body radiation therapy (sbrt). therefore, for patients who are not eligible for surgery due to their significant co-morbidity, or for those who refuse surgical resection, stereotactic radiotherapy is an efficient practical alternative. sbrt is well tolerated and efficient, in fact local control rate at 3 years reaches more than 90%. most of guidelines recommand a dose between 48 and 60 gy delivered in 3 at 8 fractions and 3 weeks. biological effect depends on the dose distribution in time and decreases when the number of fractions or length of radiation treatment increase. decreasing the length of treatment and the interval between fractions may improve efficiency of treatment and local control rate. moreover, it may improve quality of life of patients. nevertheless, an evaluation of safety of such shorter treatment course, with a phase i-ii clinical study is needed.

intervention : stereotactic body radiation therapy in the treatment of stage ia - ib non small cell lung cancer (t1n0m0 or t2an0m0) study type : interventional study design : endpoint classification : safety/efficacy study intervention model : single group assignment masking : open label primary purpose : treatment

Eligibility criteria:
inclusion criteria: * histologic or cytologic diagnosis of non small cell lung cancer stage ia-ib (t1n0m0 or t2an0m0) * none histologic or cytologic diagnosis of non small cell lung cancer stage ia-ib (t1n0m0 or t2an0m0) with evolutionary criteria (increase on two successive ct scan and pathological hyperfixation in the tep scan) * resectable tumor but patient unfit for surgical resection * resectable tumor but patient refusing surgical resection * kps \> 60% * pulmonary functions: fev \> 40% theoric value, po2 ≥ 70mmhg, pco2 \< 50mmhg * patient who can hold appropriate immobilization in dorsal decubitus during approximately 30 minutes * age 18 years or older * not affected by a mental disease * understanding and be informed of the investigational nature of this study and must give written consent prior to the receiving of treatment per this protocol * inscription at the french social security exclusion criteria: * patient pregnant * patient deprived of freedom or under guardianship * pulmonary functions : fev \ 50mmhg * prior thoracic radiation treatment * prior radiation pneumonitis
drinking in young adult duos (dyad) study

Conditions: Alcohol Consumption; Alcohol Drinking; Alcohol Intoxication

Summary: this study examines the role of alcohol use in understanding the dynamics of romantic relationships. couples will participate in a research session where they consume either an alcoholic or non-alcoholic beverage and complete study tasks. after the session, participants will provide information about their drinking habits, alcohol- and non-alcohol-related experiences, and relationship factors through brief surveys on their smart phones and again at 6-month and 12-month follow-up sessions. the findings from this study aim to improve understanding of alcohol use in close relationships and may inform future strategies for promoting healthier relationships and behaviors.

this study investigates alcohol consumption in romantic relationships. couples will be recruited to participate in a laboratory-based alcohol administration session, during which they will consume either a moderate dose of alcohol or a non-alcoholic beverage. following beverage consumption, couples will complete questionnaires and tasks. the study employs a multi-method approach to assess alcohol in couples, including self-reports and behavioral tasks, both inside and outside of the lab (e.g., using ecological momentary assessment). additionally, participants' drinking patterns and relationship factors will be tracked over time, with follow-up assessments conducted at 6-months and 12 months post-laboratory session. the findings from this research will provide insights into the role that alcohol consumption plays in close relationships and may inform interventions to support healthier drinking behaviors and relationship outcomes.

Eligibility criteria:
inclusion criteria: both members of the couple must: * be between the ages of 21 and 30 * regularly consume alcohol * own a smartphone exclusion criteria: neither member of the couple: * has a history of adverse reaction to the amount of beverage used in the study * has a history of major problems related to alcohol * is taking medications that could adversely interact with alcohol * is pregnant

Keywords: alcohol administration couples
efficacy of stellate ganglion block in children with autistic disorder

Conditions: Autistic Disorder

Summary: the goal of this clinical trial is to explore efficacy of stellate ganglion block children with autistic disorder. the main question it aims to answer is: can stellate ganglion block improve the autistic disorder in children? children with autistic disorder will be divided into the control group and experimental group evenly. all the patients were provided with routine therapy, while the patients in the experimental group were given stellate ganglion block. the childhood autism rating scale of the two groups of patients before and after treatment are evaluated.

autistic disorder in children is becoming increasingly more. the goal of this clinical trial is to explore efficacy of stellate ganglion block children with autistic disorder. the main question it aims to answer is: can stellate ganglion block improve the autistic disorder in children? children with autistic disorder will be divided into the control group and experimental group evenly. all the patients were provided with routine therapy, while the patients in the experimental group were given stellate ganglion block. the childhood autism rating scale of the two groups of patients before and after treatment are evaluated.

Eligibility criteria:
inclusion criteria: * diagnosed as autistic disorder. * aged between 6 years old and 12 years old. * no contraindications to stellate ganglion block. exclusion criteria: * other significant physical or neurodevelopmental disorders. * other significant medical conditions
correlation between the incidence of covid-19 in nursing-homes and the profile of nursing homes in the french alps

Conditions: Covid19; Nursing Home

Summary: since the beginning of the covid-19 outbreak in france, nursing homes (nh) have been heavily affected. in this study, the investigators want to evaluate the factors associated with the occurrence of covid-19 epidemic clusters within the nursing homes in the french alps

in france, between 1st of march and 29th of june 2020, the situation of nh was critical, with a total of 5,203 outbreaks (≥ 1case), of which 651 (13%) occurred in the auvergne-rhône-alpes (ara) area. in the ara area, 3,885 residents of nh were confirmed cases (positiveness of the polymerase chain reaction (pcr) or of the serology testing), of which 1,772 (46%) subsequently died. to manage this crisis, the french government decided to first, ban the visits to residents and to reinforce hygiene measures targeting care workers, and secondly, of a national lock down. in the same time, shortage of personal protective equipment (ppe) had happened worldwide. in this context, one can hypothesize that the occurrence of outbreaks and its spread among the residents of nh would have been initiated by the staff members. nonetheless, the implementation of local actions might have been efficient to mitigate the epidemic, while on the other hand, shortage of ppe might have worsen the epidemic. therefore the investigators aimed to investigate the relationship between the occurrence of outbreak in residents and in staff members of nursing home, as well as the factors influencing this relationship, using data from a multicentric cross-sectional survey conducted in the french alps, a part of ara area.

Eligibility criteria:
inclusion criteria: * hospital based nh in the french alps * non hospital based nh in the french alps * study participation agreement from the nh's managers exclusion criteria: * refusal of the nh's managers to participate

Keywords: covid19 nursing home
effectiveness of freedom bed compared to manual turning in prevention of pressure injuries in persons with limited mobility due to traumatic brain injury and/or spinal cord injury.

Conditions: Pressure Ulcer

Summary: observational comparison on incidence of pressure injury between the freedom bed automated continuous lateral rotation therapy system and manual caregiver re-positioning every 2 hours on a standard hospital bed.

this study will include 8 vent dependent subjects with comparable diagnoses and nutritional levels. of the subjects selected, 4 subjects will be placed on freedom beds and 4 will be placed on standard hospital beds for a period not less than 6 months. a waiver of informed consent is required prior to bed placement and data collection. consented subjects will have primary and secondary diagnosis recorded, pressure mapping in supine 30-degree elevation, assessment of ventilator / oxygen support measured, oxygenation levels, nutrition levels, and estimated cardiac condition. subjects will receive daily skin assessments and treatment as prescribed by the attending physician with weekly measurements and reporting of values. subjects will continue until they reach one of the study endpoints: 1) discharge from the vent unit, or 2) withdrawal of informed consent, or 3) completion of the 6-month study. subjects placed on the freedom bed will be automatically turned in accordance with positions determined as optimal by initial pressure mapping and approved by the attending physician. all programmable turning angles, dwell times, head and leg elevations must be "dialed in" within a week of the study beginning. any modification to the program during the study must be approved by the care team and documented accordingly. subjects placed on standard hospital bed will require manual re-positioning every 2 hours. all turning and/or re-positioning must be timed and documented. subjects who experience either development of pressure injuries, or worsening of their skin condition to the point a specialty bed is required will be deemed a test failure. the primary and secondary outcome measures documented on each subject throughout the week will be collected by the clinical research coordinator (crc) on a weekly basis and submitted to the principal investigator. the weekly reports will then be consolidated by the crc into a monthly report and submitted to the institutional review board (irb), principal investigators (pi) and supervising authorities (sa) for review.

Eligibility criteria:
inclusion criteria: subjects or their legal representative able to provide written consent for study must be rated between 6-12 on the baden scale must be immobile and unable to preposition themselves. must be within weight range of designated support surface. exclusion criteria: subjects with unstable spinal fractures. subjects with significant involuntary spasms. subjects with severe scoliosis. a user must be able to lie in a partial back lying position. subjects considered morbidly obese.
fish oil and muscle function

Conditions: Sarcopenia

Summary: the purpose of this study is to examine the effect of omega-3 fatty acid supplementation on changes in muscle mass, muscular strength and physical function.

loss of muscle mass is a normal consequence of aging in many older adults, worsened by chronic illness, poor appetite and diet, and reduced physical activity. the ensuing decline in physical function is a major cause of frailty, disability and death. treatments that can reverse or reduce the age-associated loss of muscle mass are therefore much needed. evidence is emerging that consumption of fish or fish oil derived long-chain omega-3 polyunsaturated fatty acids (lcn-3pufa) may be important for maintenance of muscle mass and physical function throughout the life-span. however, the effect of lcn-3pufa supplementation on muscle mass, muscle strength and overall physical function is not known. the goal of this study therefore is to determine the effect of lcn-3pufa supplementation on muscle mass, muscle strength and physical function in older adults.

Eligibility criteria:
inclusion criteria: * non-obese (i.e., bmi less than 35 kg/m2) * between 18 to 45 or between 60 and 85 y old * subjects who are sedentary (\<1 h of exercise/week) exclusion criteria: * subjects with evidence of significant organ system dysfunction (e.g. diabetes, severe cardiovascular disease, hyperlipidemia, cirrhosis, hypogonadism, uncontrolled hypo- or hyperthyroidism; uncontrolled hypertension) * subjects with metal implants * subjects with iron storage disease, * subjects with severe ambulatory impairments, * individuals with cancer or cancer that has been in remission for \<5 years, * individuals with dementia, * individuals who smoke, * subjects who are taking medications known to affect muscle (e.g., steroids), * subjects who receive anticoagulant therapy. * subjects taking medications to control certain medical conditions (e.g., hypertension) will be included if the drug regimen has been stable for at least 6 months before entering the study and is not expected to change during the study. * subjects with allergies to sea food, * subjects who regularly consume fish oil or consume \>2 servings of fish with a high lcn-3pufa content (e.g. salmon, mackerel, sardines, etc) per week. * physical performance test score less than 17 out of 36.
structure and function of retinal disease

Conditions: Retinal Toxicity

Summary: current clinical cameras do not allow clinicians to see the cells of the retina. this study will evaluate a new electronic camera's ability to image the human retina in finer detail.

this research study will (1) test the ability of a new electronic camera developed in dr. miller's laboratory to collect extremely sharp volumetric images of the retina in human subjects, and (2) use the camera for addressing fundamental questions about how disease progresses in the eye. this new camera integrates cutting-edge technologies in adaptive optics (ao) and optical coherence tomography (oct) that enable the camera to capture sharp images. however, many aspects of the camera are already employed in clinical instruments used routinely by eyecare practitioners worldwide. the objective of our study is to find out (1) whether the ao-oct camera will allow researchers to observe and quantify finer detail in the retina than current clinical cameras, and (2) whether this finer detail is useful for understanding the progression of disease in the eye. to address the second objective, the study will look at two subgroups of retinal disease. the first is age-related macular degeneration (amd), a leading cause of blindness in the developed world. because this disease is difficult to study directly as it takes years to progress, we will study it indirectly using subjects with a form of retinal toxicity that exhibits a retinal phenotype similar to that of amd but progresses on a much faster time scale. the second disease subgroup is inherited retinal degeneration that affects as many as 1 in every 2,000 people worldwide. for this subgroup, the researchers will test the exquisite sensitivity of the ao-oct imaging system to detect minute changes in disease progression over short periods of time covering weeks and months.

Eligibility criteria:
inclusion criteria: * retinal disease of either inherited retinal degeneration or retinal toxicity exclusion criteria: * ocular media opacities * high refractive error * pupil dilation imposes a risk to ocular health

Keywords: retinal toxicity
comparison of tendon repair and physiotherapy in the treatment of small and medium-sized tears of the rotator cuff

Conditions: Rotator Cuff Tear

Summary: the purpose of this study is to compare treatment benefits from surgical treatment by tendon repair and from physiotherapy for small and medium-sized rotator cuff tears.

surgical treatment by tendon repair or physiotherapy are accepted treatment options for small and medium-sized rotator cuff tears, but have never been compared in randomised, controlled studies. in this study, patients presenting clinical signs together with imaging findings (mri and sonography) for a full-thickness rotator cuff tear will be randomly allocated to surgery (tendon repair) or physiotherapy. outcome measuring will be performed by the constant score, the self report section of the american shoulder and elbow surgeons score (ases), the short form 36 health survey (sf-36) and subscores for shoulder motion, pain, strength and patient satisfaction. scores will be taken at baseline and after 6 months,1, 2, 5, 10 and 15 years by a blinded assessor. all operated shoulders will be controlled by mri after one year. patients with no effect from physiotherapy after at least 15 treatment sessions will be offered secondary surgical treatment, and scoring results from last follow-up before surgery will be carried forward to analysis, according to an intention to treat principle.

Eligibility criteria:
inclusion criteria: * clinical history and imaging findings of a rotator cuff tear exclusion criteria: * presence of other local or systemic diseases influencing on shoulder function * history of earlier rotator cuff surgery * medical contraindications for surgery

Keywords: rotator cuff tear surgical repair physiotherapy treatment benefit surgery
post surgical multimodal analgesia with oral strong opioids

Conditions: Orthopedic Procedures; Arthroplasty; Fracture Fixation

Summary: this is a prospective observational case study, focusing on the clinical effectiveness of oral strong opioids for pain management following common orthopedic surgeries.the study aims to evaluate the effectiveness of multimodal analgesia with oral strong opioids, reduce common opioid-related side effects, and improve patient compliance and satisfaction.


Eligibility criteria:
inclusion criteria: 1. aged 18 or older 2. must undergo one of the following treatments: (1) fracture of upper or lower limbs or pelvis requiring internal fixation surgery (2) spinal fusion surgery (3) joint replacement surgery 3. requiring multimodal analgesics for postoperative pain control, with oral strong opioids as the primary opioid analgesic, as assessed by his/her physician. 4. voluntarily sign the informed consent form and agree to the collection of clinical questionnaires and medical-related information for this study. exclusion criteria: 1. patients who have not received any or have only received oral potent opioids for no more than 1 day during the postoperative hospitalization period (including those known to be intolerant or allergic to opioid medications). 2. patients who have received or are expected to use long-acting opioid injections within 7 days before surgery or during the postoperative hospitalization period. 3. patients who use patient-controlled analgesics for pain control after surgery. 4. patients with a history of substance abuse or who require continuous treatment with other opioid receptor agonists or antagonists (such as naloxone or methadone). 5. patients with a history of mental illness who continue to require medication control from 28 days before surgery and until discharge. 6. other cases deemed ineligible by the study investigator.