Kornimate/medical-research-clean huggingface dataset:
efficacy of hearing-aid treatment for patients with tinnitus and co-existing hearing loss

Conditions: Tinnitus, Subjective; Hearing Loss, High-Frequency

Summary: considering the extent to which has play a role in sound perception and residual hearing preservation among patients with tinnitus and co-existing hl remains a lack of compelling extensive evidence, investigators designed this single-blind, 6-months randomized, controlled trial with two parallel groups. one is the ha treatment group, and the other is the waiting list control (wlc) group which receives no interventions during this period.

in clinical practice, chronic subject tinnitus poses an important challenge. this condition can negatively affect an individual's emotional and functional well-being. in most cases, tinnitus is highly associated with hearing impairment, particularly in cases of high-frequency sensorineural hearing loss (snhl). the occurrence of tinnitus in patients with hl is one of the most prevalent sensory disabilities, causing a deleterious effect on patients' lives. nowadays, the mild to moderate snhl can be effectively managed with a fitting hearing aid (ha) by providing sound amplification, and several findings suggest that the ha may also be helpful for people with tinnitus. nevertheless, in terms of the effects of ha use for residual hearing protection for patients with tinnitus and co-existing hearing loss, inadequate attention is still paid by medical personnel, and relevant evidence remains preliminary at this point in time. to assess the full extent of tinnitus patients, investigators need to carry out a series of tests, including hearing assessment and psychometric tests. pure tone audiometry (pta) and otoacoustic emission (oae) tests are used to calculate the average hearing thresholds and the outer hair cell function, while the tinnitus hazard index (thi), the visual analogue scale (vas), the hospital anxiety and the depression scale (hads) and the athens insomnia scale-8 (ais-8) questionnaires were for patients' psychology status. investigators hypothesize that in patients with tinnitus and hearing loss, ha intervention results in better conditions of tinnitus and lower hearing threshold reduction. here investigators planned to enroll patients into two groups, the ha and non-ha (served as the control) intervention patients.

Eligibility criteria:
inclusion criteria: 1. adults aged older than 18 years old and less than 70 years; 2. chronic (\>6 months) subjective tinnitus, unilateral or bilateral; 3. diagnosed with a high-frequency snhl; 4. be available for six months after starting the study to complete the follow-up questionnaires; 5. readiness to participate in the study and sign the informed consent. 6. be covered by public health insurance and eligible for reimbursement. exclusion criteria: 1. objective tinnitus; 2. conductive hl; 3. unstable medical history that limits participation; 4. undergoing any other concurrent treatments on tinnitus or hl; 5. having used has in the past 1 year; 6. unwilling or unable to use has daily; 7. alcohol or drug abuse; 8. unable to read or write.
frozen blastocyst transfer in natural cycle

Conditions: Infertility

Summary: the rational of the study is to assess the pregnancy rate after the transfer of frozen blastocyst in natural cycle controlled by external administration of hcg.


Eligibility criteria:
inclusion criteria: * age \< 40 * bmi:18-29 kg/m2 * day 5 frozen embryo * previously ivf/icsi exclusion criteria: * oocyte donation cycles

Keywords: fet blastocyst natural cycle hcg spontaneous lh pic
treatment with cidofovir for children with laryngeal papillomatosis (warts in the throat)

Conditions: Papilloma

Summary: the purpose of this study is to see what dose of the drug cidofovir is safe to treat laryngeal papillomatosis (warts in the throat which occur over and over) in children. laryngeal papillomatosis is caused by infection with a virus called human papillomavirus (hpv). at present, there is no approved drug to treat this infection. however, cidofovir is a drug effective against several viruses. cidofovir may be able to attack the hpv virus. this study tests the safety of giving this drug to children.

your child will be assigned randomly (like tossing a coin) to receive either cidofovir or placebo (an inactive substance). neither you nor your doctor will know which your child is receiving. your child will undergo a total of 6 bronchoscopic procedures, which involves placing a tube down your child's throat so that the warts can be seen and treated. the warts will be removed by laser or other procedures and the study drug injected. study drug will be injected at the sites of all newly removed warts and warts which were removed during earlier study visits. this procedure will be performed every other week. blood and urine tests will also be performed at this time. your child will be under general anesthesia during each procedure and will be in the surgery unit for about 6 to 8 hours. your child will also have to be seen by the doctor 2 days after the procedure. your child will be followed for a total of 5 years to make sure he/she develops normally and to monitor any side effects of cidofovir. follow-up visits will take place at months 3, 6, and then once every 6 months through year 5. if necessary, laser or other procedures will be performed at these visits to remove any warts.

Eligibility criteria:
inclusion criteria: your child may be eligible for this study if he/she: * has active laryngeal papillomatosis (warts in the throat) that requires 8 or more surgeries per year. * developed this infection before the age of 16. * is between the ages of 2 and 17 years with consent of parent or guardian. exclusion criteria: your child will not be eligible for this study if he/she: * has a history of a prior malignancy (cancer), kidney disease, or immune system deficiency. * is hiv-positive. * is allergic to probenecid. * has received radiation therapy to the throat area or has received certain medications. * is pregnant or breast-feeding.
lung atelectasis improvement through positive end expiratory pressure during anesthetic induction

Conditions: Lung Injury, Acute

Summary: anesthetic induction could lead to lung atelectasis, increase intrapulmonary shunt, and potentially impair oxygenation. the study aimed to validate that a positive end-expiratory pressure (peep) of 10 cmh2o could reduce lung atelectasis, comparing to 0 or 5 cmh2o with limited overdistension.

general anesthesia may introduce lung atelectasis, which causes an increase in intrapulmonary shunt, and impairs oxygenation, even in the lung-healthy subjects. the magnitude of shunt is correlated with the formation of pulmonary atelectasis. the study aimed to validate that a positive end-expiratory pressure (peep) of 10 cmh2o could reduce lung atelectasis, comparing to 0 or 5 cmh2o with limited overdistension. surgical patients with healthy lungs were randomly assigned to receive 0, 5 or 10 cmh2o peep (peep0, peep5 and peep10 groups). anesthetic induction was performed by certified registered anesthesiologists, during which the patients were mechanically ventilated using the volume-controlled mode. electrical impedance tomography (eit) was used to dynamically assess the lung atelectasis during anesthetic induction (spontaneous, mask, and endotracheal intubation ventilation). the primary outcome was the dorsal change of end expiratory lung impedance (△eeli) after 2 mins anesthetic induction. the secondary outcome was driving pressure, eit-derived ventilation homogeneity, hemodynamics and pao2/fio2.

Eligibility criteria:
inclusion criteria: * between 18 and 80 years * scheduled for elective non-cardiothoracic cancer surgery * general anesthesia. exclusion criteria: * acute or chronic respiratory disorders, such as chronic obstructive pulmonary disease (copd) or asthma; * a history of lung surgery * a high risk of reflux and aspiration * a requirement for awake intubation * facial or thoracic deformities * the presence of implants, such as cardiac pacemakers * pregnant
longo's intervention in the treatment of hemorrhoids and rectal mucosal prolapse

Conditions: Hemorrhoids; Rectal Mucosa Prolapse

Summary: the aim of this study is to define the significance of the distance of the staple line to the dentate line of the anal canal in the efficacy of the longo's intervention.

is going to be carried out with patients from 18 to 70 years old with hemorrhoids in a level iii and iv in the lord scale. in the surgery longo's intervention would be done by two ways differing in the distance of the suture from the tobacco pouch to the anal margin (4.5 cm in the first group and 6 cm in the second group).

Eligibility criteria:
inclusion criteria: * women and men from 18 to 70 years old * hemorrhoids in level iii and iv in the lord scale * surgery without income and conventional hospitalization exclusion criteria: * previous hemorrhoidal intervention * actual anal pathology

Keywords: longo hemorrhoids rectal prolapse anal
description of the endothelial phenotypes from the subcutaneous abdominal and gluteo-femoral adipose tissues in women

Conditions: Obesity

Summary: the endothelium is a key barrier between blood and tissue compartments. it is a major target of factors involved in metabolic and cardiovascular pathologies. however, the study of native human adult endothelial cells is difficult due to the lack of appropriate models and thereafter the endothelium is actually not easily accessible for clinical investigation. however, our results recently showed that the endothelium from human adipose tissue exhibit distinct phenotypes, including endothelial cell number and inflammatory, angiogenic and senescent state, according to adipose tissue location, i.e. subcutaneous and visceral. it is well recognized that estrogens favour gluteo-femoral adipose tissue deposit and their deficit after menopause is associated with increased abdominal and visceral fat mass as well as metabolic dysfunctions. these perturbations might be prevented with hormonal therapy. however, no data are available concerning the endothelial cells from gluteo-femoral and abdominal adipose tissues in women.

the adipose tissues (gluteo-femoral and abdominal) will be obtained from women programmed for surgery in which the estrogenic status as well as adipose tissue mass profile will be evaluated. the phenotype (inflammatory and angiogenic activation and senescent state) of native endothelial cells will be determined "in situ" by immunohistochemical and flow cytometry approaches and on isolated endothelial cells by reverse transcriptase-q polymerase chain reaction and western blot. in vitro approaches will be performed 1) to establish a causal relationship between endothelial senescence and activation state, 2) to define the impact of the adipose tissue microenvironment on the endothelial cell activation and senescence and 3) to study the potential protective effect of estrogens on endothelial senescence.

Eligibility criteria:
inclusion criteria: * stable weight for at least 3 months * women undergoing a surgery of subcutaneous adipose tissue exclusion criteria: * undergoing insulin therapy * undergoing steroidal and nonsteroidal anti-inflammatory treatments * undergoing or stopped since less than 6 months immunosuppressive treatments * positive serology for hiv, hepatitis b virus and/or hepatitis c virus
development and validation of an artificial intelligence system for bowel preparation quality scoring

Conditions: Colonic Disease

Summary: the purpose of this study is to develop and validate the accuracy and reliability of an artificial intelligence(ai) system for bowel preparation quality scoring based of boston bowel preparation scoring(bbps). then evaluate whether this ai system can help endoscopists to improve the quality of colonoscopy in clinical practice.

bowel preparation is one of the most important factors which decide the quality of colonoscopy. adequate bowel preparation is essential to guarantee a clear vision of colonic mucosa, complete inspection of entire colon and improves the adenoma detection rates(adrs). therefore, the quality of bowel preparation should be evaluated accurately and objectively. however, current bowel preparation quality scales depend on memories and subjective decision of endoscopists. recently, articifial intelligence system based on deep learning algorithm has been used widely in medical fields. but, few studies have been reported to evaluate the performance of ai system based on deep learning in bowel preparation quality scoring. this study aims to develop and train an ai system to assess bowel preparation quality using the bbps, and validate the ai system to improve the quality of colonoscopy.

Eligibility criteria:
inclusion criteria: * patients aged 20-80 years undergoing elective colonoscopy exclusion criteria: * patients received colon or rectal surgery

Keywords: artificial intelligence, deep learning, bowel preparation
basal bolus of insulin aspart including insulin nph and biphasic insulin aspart in type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in europe and asia. the aim of this trial is to compare basal bolus treatment with insulin aspart and insulin nph to biphasic insulin aspart treatment on blood glucose control in type 2 diabetes.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * currently treated with human insulin or insulin analogues for at least 3 months, with or without combination with oads * hba1c between 8.0-10.5% * body mass index (bmi) below 35.0 kg/m2 * able and willing to perform self-monitoring of blood glucose exclusion criteria: * total daily insulin dose of 1.80 iu/kg or more * known or suspected allergy to trial product or related products * pregnancy, breast-feeding, the intention to become pregnant or judged not to be using adequate contraceptive measures
clinical evaluation of removing blood stasis therapy in treating acute cerebral hemorrhage safety and efficacy

Conditions: Intracerebral Hemorrhage, Hypertensive; Traditional Chinese Medicine

Summary: the purpose of this research is to use the "removing blood stasis decotion" of traditional chinese medicine treating the acute stage of cerebral hemorrhage with stroke associated pneumonia to explore the impact of "removing blood stasis therapy" on intestinal microbial flora either within the time window from 6 to 72 hours onset.

objective: to investigate the impact and immunologic mechanism of using the "removing blood stasis decotion" treatment in sap after acute cerebral hemorrhage with the concept of intestinal micro ecological regulation. methods: from 2017.01 to 2022.12, 240 cases of aich, 306 cases of hypertension will be included in 7 research centers. the aich patients are randomly into 3 groups within 6 to 72hrs from onset, thus there are 3 groups and the treatment will last for 10 days: group a，removing blood stasis herbal medicine(8 herbals); group b, herbal medicine without poxuezhuyu activating herbal(6 herbals); group c, placebo medicine of chinese medicine.all the patients will be treated according aha guideline of aich and will be set to the brain ct and chest x-ray at the onset, 24h later and 10-14days after treatment. the venous blood，feces specimen and the sputum will be collected in the time point of 6 to 72hrs within onset , 24h later, and 10-14days after treatment.so the rate of enlargement of brain hematoma and the development of sap in the 72h later, mortality rate in the two weeks and the disability rate in the 90 days can be evaluated.

Eligibility criteria:
inclusion criteria: * greater than or equal to 18 years old while younger than 80 years old * acute cerebral hemorrhage confirmed by brain ct scan within 6 to72 hours from onset * gcs≥6 * sign the informed consent form exclusion criteria: * tests have confirmed that cerebral hemorrhage caused by brain tumor, blood diseases, cerebrovascular malformation (anomaly) or aneurysm, etc; * patients with severe heart, liver and renal insufficiency. * intolerance to traditional chinese medicine (tcm), allergic constitution. * patients with severe cerebral hernia in the early onset * compliance is poor.

Keywords: blood-breaking decotion
study of arginine butyrate and ganciclovir/valganciclovir in ebv(+) lymphoid malignancies

Conditions: EBV Lymphomas; Lympho-proliferative Diseases

Summary: the purpose of this study is to assess whether administration of arginine butyrate + ganciclovir/valganciclovir for up to three 21-day cycles is tolerable, and results in partial or complete responses in patients with ebv(+) lymphoid malignancies.


Eligibility criteria:
inclusion criteria: * age ≥ 3 years. (no dosing or adverse event data are currently available on the use of valganciclovir in patients \< 16 years of age.) * life expectancy of \> 3 months. * ecog performance status 0-2 or karnofsky performance scale ≥ 60%. * baseline (untransfused) hbf level \> 2% * normal organ and marrow function defined as: (i) absolute neutrophil count of ≥ 1,000/µl. (ii) platelets ≥ 50,000/ µl. (iii) total bilirubin of ≤ 2.0 x upper limit of normal. (iv) ast (sgot)/alt(sgpt) of ≤ 2.0 x institutional upper limit of normal. (v) creatinine within normal range for institution. * women of child-bearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation. * able and willing to give informed consent. exclusion criteria: * patients that have received chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin c) prior to entry, or those who have not recovered form adverse events due to agents administered 4 weeks earlier. * patients may not be receiving any other investigational agents. * history of allergic reactions attributed to compounds of similar chemical or biologic composition to arginine butyrate, ganciclovir or valganciclovir. * patients who have an acute myocardial infarction or onset of atrial fibrillation within the past 6 months. * uncontrolled intercurrent illness including, but not limited to , ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * tumor impinging on an organ or anatomical structure deemed critical by the investigator. * pregnant women.
standard reaming versus reaming/irrigating/aspirating for intramedullary nailing of femoral shaft fractures

Conditions: Femoral Fractures

Summary: reaming (enlarging of the bone canal) is commonly performed prior to the insertion of intramedullary nails for the fixation of long bone fractures. this study is designed to compare the union rates between fractures reamed by standard reaming versus reaming with a reamer/irrigator/ aspirator (ria). in addition, this study will collect patient-based outcomes on these patients. little information exists on the patient based outcomes following femur fractures. we hope that the patient based outcomes of this study will also be able to aid physicians in advising patients with femur fractures of their possible outcomes.


Eligibility criteria:
inclusion criteria: 1. men or women between the ages of 18 years and 85 years; 2. acute fractures of the femoral shaft exclusion criteria: 1. fractures not amenable to intramedullary nailing and deemed by the treating surgeon; 2. pathological fractures; 3. open fractures; 4. patients with additional injuries to the ipsilateral femur; 5. surgical delay of greater than 7 days from the time of injury; 6. retained hardware in the affected limb; 7. previous infection in fractured limb; 8. likely problems in the judgment of the investigators with maintaining follow-up; 9. patients with severe cognitive injuries or disabilities will be excluded if it is deemed that they will be unable to complete the study questionnaires; 10. hopeless diagnosis; 11. medical comorbidities that prohibit the conductance of surgical treatment under a general anesthetic; 12. fractures requiring cephalomedullary nails
omega-3 fatty acids in bipolar patients with a low omega-3 index and reduced heart rate variability

Conditions: Bipolar Disorders

Summary: this study sets out to test the hypothesis that parameters of heart rate variability, as a non-invasive measure of cardiovascular risk, can be improved by the addition of omega-3 fatty acids in euthymic bipolar patients with a low omega-3 index and reduced heart rate variability.


Eligibility criteria:
inclusion criteria: 1. subjects must meet the dsm-iv criteria for bipolar disorders, in remission 2. age: 18 - 65 years 3. low omega-3 index (\<5%) 4. sdnn \< 60 msec 5. subjects must have adequate fluency in german or english to complete baseline and follow-up interviews and fill out the beck depression inventory 6. stable psychotropic medication for at least 2 weeks 7. subjects must be able to give written informed consent exclusion criteria: 1. subjects for whom the intake of omega-3 fatty acids is indicated according to recent treatment guidelines 2. patients on warfarin 3. subjects with any acute and life-threatening condition, such as collapse and shock, acute myocardial infarction, stroke, embolism 4. subjects with significant medical comorbidity 5. pregnant subjects - due to any possible teratogenic effects of epax 6015 tg and corn oil, respectively, on the fetus - and breastfeeding subjects. in addition, women of childbearing potential who will not practice a medically accepted method of contraception will be excluded 6. subjects who, in the investigator's judgement, pose a current significant suicidal or homicidal risk or patients who will not likely be able to comply with the study protocol 7. subjects fulfilling the dsm-iv diagnostic criteria for current substance abuse

Keywords: bipolar disorders omega-3 fatty acids heart rate
progression to impaired glucose tolerance and type 2 diabetes in the korean people-based kndp study

Conditions: Impaired Glucose Tolerance; Diabetes

Summary: impaired glucose tolerance is a metabolic state between normal glucose homeostasis and diabetes. previously, prospective studies have shown higher progression rates from igt to diabetes in other country. but there is no prospective-multicenter based reports in korea. therefore, the purpose of this study is to estimate the progression rates to impair glucose regulation and diabetes in the korean population-based korea national diabetes program.


Eligibility criteria:
inclusion criteria: * fastic serum glucose \>100 and/or pp2 serum glucose \<200 exclusion criteria: * known diabetes * organ failure(for example, liver, kidney) * known malignancy

Keywords: ngt, igt, diabetes