Kornimate/medical-research-clean huggingface dataset:
effects of transcranial direct current stimulation (tdcs) and visual illusion on chronic pain due to spinal cord injury

Conditions: Chronic Pain; Spinal Cord Injury

Summary: the purpose of this study is to investigate the effects of transcranial direct current stimulation (tdcs) combined with watching a visual illusion on chronic pain due to spinal cord injury. the investigators hypothesize that active tdcs will reduce pain in subjects with spinal cord injury when compared to sham stimulation. the investigators will also measure changes in eeg data (alpha and beta frequencies) as well as motor cortex excitability.


Eligibility criteria:
study eligibility criteria inclusion criteria: 1. providing informed consent to participate in the study 2. 18 to 64 years old 3. with traumatic spinal cord injury (complete or incomplete) - for instance, due to fall, car accident or gun shot; (for spinal cord injury only) 4. stable chronic pain for at least the three preceding months (for spinal cord injury only) 5. score higher or equal to 4cm (0 cm= 'no pain' and 10cm='worst possible pain') on the visual analogue scale (vas) for pain perception at the baseline/start of the treatment (for spinal cord injury only) 6. refractoriness to drugs for pain relief - such as tricyclic antidepressants, antiepileptic drugs and/or narcotics (pain resistant to at least 2 of these drugs supplied in adequate dosages for six months) (for spinal cord injury only) 7. pain is not attributable to other causes, such as peripheral inflammation exclusion criteria: 1. clinically significant or unstable medical or psychiatric disorder 2. history of substance abuse 3. neuropsychiatric comorbidities, including: documented traumatic brain injury (tbi), defined as damage to brain tissue caused by an external mechanical force as evidenced by: loss of consciousness due to brain trauma, or post traumatic amnesia (pta), or skull fracture, or objective neurological findings that can be reasonably attributed to tbi as assessed by the study pi 4. implanted devices for pain control, such as vagal or deep brain stimulators 5. contraindications to tdcs: * metal in the head * implanted brain medical devices 6. pregnancy 7. use of ventilators or ventilation support 8. complete tetraplegic lesion (no motor function in the arms) (c3 to c8) as we will be measuring the motor evoked potential in the fdi (upper limbs); only tetraplegic patients with incomplete functional status and also as defined by the ability to elicit mep in the fdi will be able to participate in this study

Keywords: transcranial direct current stimulation
simvastatin in waldenstrom's macroglobulinemia

Conditions: Waldenstrom's Macroglobulinemia

Summary: this research study seeks to find new ways to treat people with waldenstrom's macroglobulinemia (wm). the study is for participants with slow growing wm who otherwise might not need therapy for at least 3-6 months. simvastatin is a drug approved by the fda for lowering cholesterol. in test tube studies the study drug appears to have direct anti-cancer effect against wm tumor cells and mast cells.

objectives: to define objective response, time to progression and safety of simvastatin in waldenström's macroglobulinemia. statistical design: for this phase ii study, a single-stage design is used to evaluate the efficacy of simvastatin. with a target enrollment of 30 participants, the 95% exact confidence bounds surrounding the response estimate will be no wider than +/- 19%.

Eligibility criteria:
inclusion criteria: * 18 years of age or older * clinicopathological diagnosis of waldenstrom's macroglobulinemia * measurable disease * slowly progressing disease not requiring therapy for at least 3-6 months and who do not meet consensus panel criteria for initiation of therapy * ecog performance status of 0 or 1 * adequate organ function as defined in the protocol * patients should agree to avoid grapefruit juice which is a major inhibitor of cyp 3a4 exclusion criteria: * patients who have had chemotherapy or radiotherapy within 4 weeks prior to entering the study, or those who have not recovered from adverse events due to agents administered more than four weeks earlier * patients who have had rituximab within 3 months prior to entering the study * patients who have taken any statin in the past * patients who take cyclosporin, danazol, or gemfibrozil will be excluded * prior history of rhabdomyolysis * uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with the study requirements * pregnant or breastfeeding women * hiv-positive * patients who take verapamil will be excluded * patients with active or history of liver disease * patients who consume more than three alcoholic beverages per day

Keywords: simvastatin
comparative effectiveness of oxiris hemofilters versus conventional hemofilters in septic patients

Conditions: Sepsis - to Reduce Mortality in the Intensive Care Unit; Hemodiafiltration; Cytokine

Summary: we divided patients in 2 groups. first group was the patients who received oxiris filters during crrt. second group was the patiens who have received crrt filters other than oxiris. we compared the lab parameters (urea, creatinin, lactate, abg parameters and sofa escore with together.


Eligibility criteria:
inclusion criteria: sepsis diagnosis crrt indication exclusion criteria: patients under age of 18
the effect of a single bout of balance and coordination exercise on cognitive function in elderly people

Conditions: Aging; Cognitive Decline

Summary: individuals of advanced age are at higher risk of cognitive deterioration.a single bout of aerobic exercise was found to improve cognitive functions. the aim of this study is to explore the effect of a single bout of balance and coordination exercise versus aerobic exercise on cognitive functions among elderly people.


Eligibility criteria:
inclusion criteria: * able to undergo physical activity for 60 minutes * participates in a physical activity center at least twice a week exclusion criteria: * scores beneath 24 on mmse * unable to sign a consent form
single ascending dose (bms-813160) study

Conditions: Accelerated Intimal Hyperplasia

Summary: the primary purpose of this study is to evaluate the safety and tolerability of single oral doses of bms-813160 in healthy subjects


Eligibility criteria:
inclusion criteria: * men and women (not of child bearing potential) ages 18 to 45 * healthy subjects as determined by no clinically significant deviation from normal in medical history, physical examination, ecgs, and clinical laboratory determinations exclusion criteria: * women of child bearing potential * organ dysfunction or any clinically significant deviation from normal in medical history, physical examination, ecgs, and clinical laboratory determinations
scoring systems in icu and malnutrition

Conditions: Critical Illness

Summary: the objective of the present study was to compare the ability of acute physiology and chronic health evaluation (apache) scoring systems with the combination of an anthropometric variable score "adductor pollicis muscle (apm) thickness" to the apache systems in predicting mortality in the icu. three hundred and four patients enrolled in this prospective observational study. the apm thickness in dominant hand and apache ii and iii scores were measured for each patient upon admission. given scores for the apm thickness, were added to apache score systems to make two composite scores of apache ii- apm and apache iii- apm. the accuracy of the two composite models and apache ii and iii systems in predicting mortality of patients was compared using area under the roc curve. based on the study results, the area under the roc curves improved in composite models. therefore, it seemed that considering anthropometric variables may improve prediction of mortality in apache systems.

the baseline medical history, physical examination, acute physiology and chronic health evaluation score ii and iii (apache) were recorded for all patients. all data were collected by a single physician. the apache ii and iii scores were gathered using the method presented by knaus. the dominant hand apm thickness (as reported by the patient, or the relative) was assessed by caliper (vogel, germany) in the emergency room or at the time of the icu admission. to estimate weight for the apm thickness, multivariate logistic regression analysis was used to determine the relation between mortality and the apm thickness while controlling for other physiologic variables (12 physiologic variables for apache ii and 18 physiologic variables for apache iii).the area under the receiver-operating curves (roc curve) to predict mortality was used to compare apache ii, apache iii, apache ii- apm and apache iii- apm systems.

Eligibility criteria:
inclusion criteria: * older than 16 years of age exclusion criteria: * splints, in the upper extremities * casts in the upper extremities * edema in the upper extremities * patients with readmission during the study period * those transferred from other icus

Keywords: mortality anthropometry nutrition assessment caliper
vinorelbine plus capecitabine versus docetaxel plus capecitabine in anthracycline-pretreated women with metastatic breast cancer

Conditions: Anthracycline-pretreated Metastatic Breast Cancer

Summary: docetaxel plus capecitabine in anthracycline-pretreated metastatic breast cancer is a recommended scheme in national comprehensive cancer network (nccn) guideline. vinorelbine plus capecitabine is also effective in metastatic breast cancer (mbc) in some clinical study with small sample.

a randomised controlled trial of vinorelbine plus capecitabine versus docetaxel plus capecitabine in anthracycline-pretreated women with metastatic breast cancer. the primary endpoints of the study is progression free survival (pfs). the secondary endpoints are overall response rate (orr), overall survival (os) and safety.

Eligibility criteria:
inclusion criteria: * female ≥ 18 years old ecog 0-2 exclusion criteria: * brain metastasis
vasovist endoleak study

Conditions: Abdominal Aortic Aneurysm

Summary: after endovascular treatment of an abdominal aortic aneurysm, lifelong imaging follow-up is needed to monitor the effectiveness of the treatment. one parameter in this follow-up is endoleak, which is leakage of blood into the aneurysm sac. the aim of this study is to investigate the value of magnetic resonance imaging using vasovist as a contrast agent for the detection of endoleaks.

after endovascular abdominal aortic aneurysm repair, life-long follow-up is needed to monitor the effectiveness of exclusion of the aneurysm sac from blood flow. for this reason, aneurysm diameter and the presence of endoleaks is evaluated with computed tomographic (ct) angiography yearly after endovascular aneurysm repair (evar). the aim of this study is to investigate the value of magnetic resonance imaging using vasovist as a contrast agent for the detection of endoleaks. the advantages of magnetic resonance imaging with respect to cta are no use of ionizing radiation, use of less nephrotoxic contrast agents.

Eligibility criteria:
inclusion criteria: * patient is more than one year after endovascular abdominal aortic aneurysm repair * patient has a stable or growing aneurysm according to diameters measured on ct angiography images * no evidence of endoleak on recent ct angiography exclusion criteria: * contraindication for mri examination * claustrophobia * pacemaker * other non-mri compatible implants * contraindication for use of contrast agent * known allergy to drugs or contrast media * mri examination with the use of gadolinium within 24 hours of the blood-pool agent injection * severe renal impairment = creatine \> 2 mg/dl (=176 mmol/l) * patient clinically instable * participation in drug research within 30 days before and 1 day after mri-examination with use of vasovist.

Keywords: endoleak
acupuncture for back and neck pain in an emergency room setting

Conditions: Back Pain; Neck Pain; Anxiety; Range of Motion

Summary: this study aims to examine the efficacy of an integrative approach utilizing acupuncture as an add-on therapy for the treatment back and neck pain in an emergency department setting acupuncture is well established as an effective treatment for back pain. the investigators cumulative experience in asaf harofeh medical center has shown acupuncture to be an effective therapy for simple back and neck pain in an er setting. this study will examine weather acupuncture can decrease pain, increase range of motion and decrease anxiety in patients admitted to the emergency room with simple back and neck pain without neurological findings. acupuncture will be performed as an add on therapy on top of analgesic therapy.


Eligibility criteria:
inclusion criteria: * adult male and females age 18-60 with acute or sub acute/chronic simple back or neck pain * agreed to a physical examination and by an orthopedic physician and x-ray * diagnosis of simple back pain with levels of 4\<nrs at least * agreed and able to fill pain, anxiety and satisfactory questioners * agreed and able to sign informed consent exclusion criteria: * fracture, sprain or neurological deficit during physical examination * pain scale of nrs\< 4 * referred or radiating pain * active pregnancy * active inflammatory arthritis * history of cva * open wounds * acute malignancy with life expectancy of less than 5 years * experience with acupuncture treatments * history of drug addiction * history of osteoporosis * declined or unable to sign informed consent * soldiers in active military service

Keywords: back pain neck pain anxiety range of motion
effects of radiofrequency ablation of posterior nasal nerves on inflammatory cytokines, peak nasal inspiratory flow, and nasal blood flow in patients with chronic rhinitis

Conditions: Chronic Rhinitis

Summary: the purpose of this study is to assess the effectiveness of radiofrequency ablation (rfa) of the posterior nasal nerve (pnn) in chronic rhinitis (cr) patients by comparing patient reflective total nasal symptom score (rtnss) and nasal obstruction symptom evaluation (nose) , peak nasal inspiratory flow (pnif) , and levels of type 2 cytokines pre- and post-procedure.


Eligibility criteria:
inclusion criteria: * chronic rhinitis symptoms for at least 6 months (rhinorrhea, congestion, post-nasal drip) * poor response to medical management that was attempted for at least 4 weeks * a rtnss score ≥6, as well as ≥2 for rhinorrhea, and ≥1 for congestion. exclusion criteria: * active sinusitis * rhinitis medicamentosa * recurrent and ongoing epistaxis * immunodeficiency as defined by an illness or a history of sinus surgery.

Keywords: radiofrequency ablation
somnodent vs herbst in mild and moderate osa patients

Conditions: Obstructive Sleep Apnea

Summary: obstructive sleep apnea (osa) is a common chronic sleep disorder that often requires lifelong care. the prevalence in the netherlands is estimated around 300.000 patients. due to longer life expectancy and increase in weight in the general population, its prevalence is expected to rise. patients with mild and moderate osa are treated primarily with an oral appliance at present time. different oral appliances are available, but most used is the mandibular advancement device (mad). this study focuses on two different types of mad: the classic herbst appliance, which is attached to the mandible and the maxilla and has an iron bar to regulate the open space; and the somnodent, which consists of two separate splints, fixed on the mandible and the maxilla, but has no iron bar attached.


Eligibility criteria:
inclusion criteria: * 18 years and older * ability to speak, read, and write dutch. * ability to follow-up. * ability to use a computer with internet connection for online questionnaires. * diagnosis with symptomatic mild or moderate osa (5 \< ahi \< 30). * expected to maintain current lifestyle (sports, medicine, diet, etc.) exclusion criteria: * untreated periodontal problems, dental pain, and a lack of retention possibilities for an mad. * medication used/related to sleeping disorders. * evidence of respiratory/sleep disorders other than osa (eg. central sleep apnea syndrome). * systemic disorders (based on medical history and examination; e.g. rheumatoid arthritis) * temporomandibular disorders (based on the function examination of the masticatory system). * medical history of known causes of tiredness by day, or severe sleep disruption (insomnia, periodic limb movement disorder, narcolepsy). * known medical history of mental retardation, memory disorders, or psychiatric disorders. * reversible morphological upper airway abnormalities (e.g. enlarged tonsils). - inability to provide informed consent. * simultaneous use of other modalities to treat osa. * previous treatment with a mad.

Keywords: oral appliance therapy
epidemiology of urinary functional disorders in women of 40 and more

Conditions: Menopause; Overweight; Surgical Antecedent; Gestity

Summary: assess prevalence of urinary functional disorders in women of 40 and more, visiting a general practitioner, occupational medicine or health examination center in puy-de-dôme. study conducted for a month using a self-filled survey distributed by secretaries or nurses.

the diagnosis of urinary incontinence is clinical. three types of urinary incontinence are described: urinary stress incontinence, urinary incontinence by overactive bladder or mixed urinary incontinence. to standardize the medical examination and to precise the urinary incontinence type, the use of a validated questionnaire is recommended (usp), the quality of life's resounding also must be assessing, using questionnaire of quality of life valid in french (iciq®, contilife®...) several medical cares exist, but patients often don't know it. unhappily, it is still a taboo subject. in a french medical study, conducted in 1992 by 60 general practitioners, of a total of 2911 female patients, 37% said they had urinary disorders. among them, 77% said they had symptoms during an effort, 57% had urinary urge incontinence and 35 % had spontaneous leaks. one in five women had three associated disorders. in a french study conducted in 2005, it appeared that women talked to their general practitioner about urinary disorders only four or five times out of ten, and six times out of ten when they used panty liners. the results are eloquent, but the data is not recent, and the investigators need some, to propose better cares. this medical study will be conducted during one month. two self-filled questionnaires will be distributed by nurses or medical secretary, working at recruited general practitioner's place, to every female patient who will be 40 years old or more, coming for themselves or accompanying somebody else (children for example). every female patient will have to fill both questionnaires alone, anonymously, and will have to let them in a closed box, in the waiting room. the two self-filled questionnaires are called usp and contilife. they are both validated to evaluate symptoms and quality of life. additional question about existence of fecal incontinence (and its type), and the reasons why patients didn't talk about it with their general practitioner spontaneously (shame, absence of information about cares, fatality...). prior visit of each recruited service by julie de la roque, to explain the goals of the study, to general practitioners, nurses and medical secretaries.

Eligibility criteria:
inclusion criteria: * female * 40 and more * speaking french exclusion criteria: * men * female of less than 40 * not speaking french * refusal * inability to answer questions

Keywords: incontinence female observational study self filled survey epidemiology
evaluation of liver damage in patients with anorexia nervosa by blood biomarker analysis

Conditions: Anorexia Nervosa

Summary: the main goal of the biocollection in anorexia nervosa-liver damage evaluation bilan study the blood biomarkers associated with liver cytolysis.

study of the association between blood biomarkers and the presence of hepatic cytolysis, defined by ast and/or alt above normal.

Eligibility criteria:
inclusion criteria : * patient over 15 years old * diagnosis of restricted eating disorders including anorexia nervosa according to the diagnostic and statistical manual of mental disorders (dsm-5) * admission to nantes university hospital. exclusion criteria : * chronic active viral hepatitis * hemochromatosis * other genetic, autoimmune. * treatment with a drug known to induce fatty liver disease (amiodarone, carbamazepine, tamoxifen, valproate, clozapine, anti-retrovirals) unless the dose has been stable for ≥ 3 months * excessive alcohol consumption (≥ 30 grams per day in men, ≥ 20 grams per day in women) * pregnant, parturient or breast-feeding women, persons deprived of liberty, adults under legal protection or unable to express their consent, persons not affiliated or not beneficiaries of a social security scheme, persons under guardianship or curators

Keywords: biomarkers liver fibrosis liver steatosis anorexia nervosa enteral refeeding
rasagiline in early parkinson's disease patients not treated with levodopa in china

Conditions: Parkinson's Disease

Summary: rasagiline has been developed for the treatment of parkinson's disease (pd), as monotherapy in early pd patients not treated with levodopa, and as adjunct therapy to levodopa in levodopa-treated pd patients with motor fluctuations. the rationale for conducting this study is to evaluate the efficacy, tolerability, and safety of rasagiline compared to placebo in chinese pd patients not treated with levodopa.


Eligibility criteria:
inclusion criteria: * patients with idiopathic pd. * patients with a modified hoehn and yahr stage \<3. exclusion criteria: * patients with a clinically significant or unstable medical or surgical condition that would preclude his/her safe and complete study participation. * patients with a clinically significant or unstable vascular disease. * patients with a clinically significant psychiatric illness, including a major depression, which compromises their ability to provide consent or participate fully in the study. * patients with a mini mental state examination (mmse) score ≤24. * patients with a diagnosis of melanoma or a history of melanoma, or a suspicious lesion. other inclusion and exclusion criteria may apply.

Keywords: rasagiline azilect parkinson´s disease motor fluctuations