Kornimate/medical-research-clean huggingface dataset:
transforming robot-mediated telerehabilitation: citizen science for rehabilitation

Conditions: Hemiparesis; Stroke

Summary: the purpose of this study is to advance upper limb robot-mediated tele-rehabilitation for patients recovering from stroke by empowering them through active science participation. by varying the tasks' features and affordances of a platform that combines a low-cost haptic device on one hand, and an online citizen science platform on the other, investigators will evaluate different strategies for social telerehabilitation. the two fundamental modes of social interaction - competition and cooperation - in addition to a control condition. specifically, citizen science activities will be performed by competing, cooperating, or isolated users, and their rehabilitation effectiveness examined. such effectiveness will be measured by (i) participants' rehabilitation performance (inferred from sensorimotor data acquired through the platform and directly quantified by a supervising therapist); (ii) participants' motivations to contribute (measured through surveys administered online); and (iii) participants' emotional well-being and sense of self-esteem (measured through online surveys).


Eligibility criteria:
inclusion criteria: for treatment group: * post-stroke hemiparesis \>3 months * ability to stand or sit independently * sufficient cognitive skills to perform the exercises as demonstrated * full passive range of motion in the affected arm but limited active movement as determined by a upper extremity fugl-meyer score of \<50/66 * technical savvy and interest to use an internet platform for control group: (ii) no history of learning disabilities (iii) technical savvy and interest to use an internet platform exclusion criteria: for treatment group: * visual deficit such as deficit in visual acuity, eye movements, visual field cut, or neglect * medical comorbidity such as other neurological conditions (e.g. parkinson's disease, brain tumor, epilepsy), or previous injury to the upper limb * pain in the upper limbs that prevents full passive range of motion to perform the exercises. for control group: * visual deficit such as deficit in visual acuity, eye movements, visual field cut, or neglect * any previous injury or medical condition that prevents full passive range of motion to perform the exercises.

Keywords: cognitive skills technical internet platform stroke hemiparesis
autonomic nervous system activity and oculocardiac reflex.

Conditions: Bradycardia During Pulling of Eyeball

Summary: pulling the eyeball during ophthalmic surgery provokes decrease in heart rate. this phenomenon is called oculocardiac reflex. in some patients asystole may occur. other cardiac features of this reflex include hypotension, dysrhythmias, atrioventricular block. these cardiovascular disturbances may lead to decreased perfusion and ischemia of vital organs. patients with existing cardiovascular disease are in risk of complications. cardiovascular system is mainly innervated with autonomic nervous system (ans). sympathetic/parasympathetic activity may be determined by heart rate variability (hrv). hrv analysis based on short 5 minutes electrocardiography has been found useful for prediction of hypotension and bradycardia during induction of general anaesthesia and during spinal block. the aim of this study is to verify whether it is possible to predict oculocardiac reflex with the use of hrv analysis for ans activity assessment, measured prior to the ophthalmic surgery.


Eligibility criteria:
inclusion criteria: * planned surgery * over 18 years of age * surgery under general anaesthesia exclusion criteria: * urgent surgery * under 18 years of age and over 65 * patients with generalised, nontreated disease * patients receiving beta blockers or calcium channel blocker * diabetic patients * patients operated under peri or retrobulbar anaesthesia

Keywords: oculocardiac effect bradycardia hrv
comparison between serratus anterior plane block and erector spinae plane block for mastectomy

Conditions: Breast Cancer Postoperative Pain

Summary: in this study, we are comparing two different techniques of plane blocks to control postoperative mastectomy pain serratus anterior plane block and erector spinae plane block, both are done with ultrasonic guidance we are recording the first time of analgesia request postoperatively as a primary outcome


Eligibility criteria:
inclusion criteria: * female patient age 20 to 65 * asa i, ii * scheduled for mastectomy exclusion criteria: * allergy to local anaesthetics * infection at the site of performing the block * morbidly obese patient of body mass index more than 40 kg/m2
open-label, safety and efficacy study of pulmicort® turbuhaler® in japanese children with bronchial asthma

Conditions: Asthma

Summary: to investigate the effect and safety of budesonide turbuhaler® 100 μg/dose and 200 μg/dose twice daily for 6 weeks in japanese children with bronchial asthma aged 5 years to 15 years old in need for inhaled glucocorticosteroid treatment. to compare the efficacy of budesonide turbuhaler® 100 μg/dose and 200 μg/dose twice daily for 6 weeks to that of fluticasone diskus® 50 μg/dose and 100 μg/dose twice daily for 6 week.


Eligibility criteria:
inclusion criteria: * provision of signed written informed consent by patient's legal representative; when possible a signed written informed consent should be obtained from the patient themselves * patients diagnosed as having bronchial asthma regardless of type of asthma i.e. perennial or seasonal, atopic or non-atopic * males/females 5-15 yrs old who are able to experience to inhale with turbuhaler and diskus. the investigator will check whether the patient can inhale appropriately using training devises and "turbuhaler trainer" * patients with bronchial asthma who require treatment with inhaled steroids (patients with drug therapy, in whom asthma is poorly controlled) * patients who are already treated with inhaled gcs should have at least 3 months prehistory of asthma before obtaining the written informed consent exclusion criteria: * use of regular(more than 3 days) systemic (oral, intravenous or intramuscular) steroids within 30 days before the observation period * the daily dose of inhaled gcs within 30 days before the observation period for the patients who are already treated with inhaled gcs is beyond fluticasone propionate (fp) 200 µg/day or beclomethasone dipropionate (bdp) 200 μg/day. * respiratory infections that, in the opinion of the investigator(s), may affect the efficacy evaluation e.g. lower airways infection such as pneumonia, infection with no available effective antimicrobial drugs or with deep seated mycosis within 30 days before the observation period. * concurrent serious diseases of liver, kidney, heart or other complications which, in the opinion of the investigator(s), may either put the patient at risk because of participation in the study, or may influence the results of the study, or the patient's ability to participate in the study * contra-indications (e.g., known or suspected allergy) to budesonide, fluticasone or lactose contained in the investigational product * participation in another clinical study within 12 weeks prior to the observation period or during the study * previous enrolment in the present study * current use of budesonide turbuhaler * pregnancy or possible pregnancy, or planning to be pregnant during the study period * patients whose legal representative/caregiver is involved in the planning and conduct of the study (applies to both astrazeneca staff or staff at the study site) * other subjects who are considered inappropriate to participate in this study as judged by the investigator

Keywords: asthma bronchial
effect of an unsupervised multi-domain intervention on injury risk reduction in athletics (i-reductai).

Conditions: Injury

Summary: in athletics, injuries can affect athletes' participation in athletics, their performance and career, but also their health in physical, psychological and social aspects, in the short, medium and long term.

this justifies the development and implementation of injury risk reduction strategies. these should be developed according to a holistic approach that considers the complex aetiology of injuries in sport. although many different injury risk reduction strategies have been studied in sport, in general, each has been evaluated in isolation, including for example education, neuromuscular exercises, psychological techniques or individual injury risk assessment. the investigators therefore hypothesized that their combination could improve the overall effectiveness of an intervention aimed at reducing the risk of injuries in athletics.

Eligibility criteria:
inclusion criteria: * be licensed at the french athletics federation (ffa) for competition (sprints, hurdles, jumps, throws, combined events, and endurance disciplines), without any counter-indications for competitive athletics activity attested by the license at the ffa; * have daily access to a digital device (smartphone, computer, tablet) with a network connection (public or private). exclusion criteria: * any athlete deprived of liberty or subject to legal protection (guardianship, under curatorship, legal protection).

Keywords: neuro muscular athletics injury prevention
characterization of the pathobiology of early lung destruction in alpha 1-antitrypsin deficient individuals

Conditions: Emphysema; Lung Diseases, Obstructive; Alpha 1-Antitrypsin Deficiency

Summary: alpha 1-antitrypsin-deficient individuals develop severe destructive lung disease much earlier and their lung function declines faster than the general population of individuals with chronic obstructive lung disease. this study is designed to better understand the pathogenesis of lung destruction in alpha 1-antitrypsin deficient individuals and to characterize the pathobiology of early lung destruction. to accomplish this we intend to use bronchoalveolar lavage to determine and quantify the factors that initiate and sustain lung inflammation in alpha 1-antitrypsin deficient individuals with lung function above a force expiratory volume in one second (fev1) of greater than 50% of predicted.

alpha 1-antitrypsin-deficient individuals develop severe destructive lung disease much earlier and their lung function declines faster than the general population of individuals with chronic obstructive lung disease. this study is designed to better understand the pathogenesis of lung destruction in alpha 1-antitrypsin deficient individuals and to characterize the pathobiology of early lung destruction. to accomplish this we intend to use bronchoalveolar lavage to determine and quantify the factors that initiate and sustain lung inflammation in alpha 1-antitrypsin deficient individuals with lung function above a force expiratory volume in one second (fev1) of greater than 50% of predicted.

Eligibility criteria:
any alpha 1 antitrypsin-deficient individuals. 18-65 years old. fev1 greater than 1 equal to 50 percent of predicted (forced expiratory volume). study participation is required for one year. a total of four bronchoscopies will be performed over a year period. methacholine challenge test will be performed at the beginning and end of the study to assess the degree of reactive airways disease. pneumococcal and annual influenza vaccine will be given. no prolastin within one year prior to start of the study. no oral systemic corticosteroids within 30 days prior to start of study. no allergy to topical or local anesthetic (i.e., lidocaine). no pregnancy. no hiv positive patients. no hepatitis b/c virus positive patients. no patients with any condition associated with immunodeficiency. no patients with presence of significant cardiac diseases. no patients with presence of uncorrected blood-clotting disorders. no patients with any oxygen at home on a regular basis. no adverse reactions to methacholine.

Keywords: alpha 1-antitrypsin deficiency emphysema genetic diseases inflammation nitric oxide protease
right hepatectomy in patients beyond 70 years old

Conditions: Complications; Liver Failure, Acute

Summary: as a consequence of the increase in life expectancy, hepato-biliary surgeons have to deal with an emerging aged population, which has a potential higher risk for complication and worse long-term outcome. the investigators will be analyzing the liver function and outcome after right or extended right hepatectomy in patients over 70 years old.


Eligibility criteria:
inclusion criteria: * age \>= 18 years * elective right hepatectomy * elective extended right hepatectomy exclusion criteria: * age \< 18 years * pregnancy * other type of hepatectomy * emergency hepatectomy

Keywords: complications mortality liver failure
the 22g trident needle combined with different aspiration techniques for endoscopic ultrasound-guided fine-needle biopsy

Conditions: Pancreatic Diseases

Summary: the goal of this clinical study is to compare the tissue adequacy, cellularity, blood contamination, accuracy, sensitivity, specificity of the 22g trident needle combined with three different aspiration techniques (dry-suction, wet-suction, and slow-pull) in endoscopic ultrasound-guided fine-needle biopsy for solid pancreatic lesions.

patients who met the inclusion criteria of this trial and did not meet the exclusion criteria were randomly divided into six groups according to the crossover grouping design. samples were collected using a 22g trident needle in different suction sequences. the advantages and disadvantages of different suction techniques in terms of sample quality and diagnostic efficacy were compared to further clarify the optimal suction sampling scheme for endoscopic ultrasound-guided fine-needle biopsy (eus-fnb) using a 22g trident needle.

Eligibility criteria:
inclusion criteria: * (before the trial, subjects must meet all of the requirements listed below in order to be enrolled) 1. 18-80 years old (inclusive), male and female; 2. patients with pancreatic solid mass \> 1cm detected by ct/mri/pet-ct or eus and requiring eus-fnb diagnosis. 3. written informed consent was obtained. exclusion criteria: * (before the trial, participants could not be enrolled if they met any of the following requirements) 1. contraindications to endoscopy, such as severe cardiovascular and cerebrovascular diseases; 2. bleeding coagulation dysfunction (prothrombin international normalized ratio ≥1.5, platelet count ≤ 50 000) or use of antiplatelet drugs; 3. confirmed pregnancy or possible pregnancy; 4. pathological diagnosis has been obtained by other methods; 5. refuse to participate in the study, are participating in another observational clinical trial, or have participated in another clinical trial within 60 days. 6. other situations where eus-fnb could not be performed.

Keywords: eus-fnb solid pancreatic lesion sample processing
the effect of paricalcitol on creatinine filtration, secretion and glomerular filtration rate

Conditions: Chronic Kidney Disease

Summary: the purpose of this study is to study the effects of paricalcitol (zemplar) on kidney functioning. the investigators hypothesize that the increase in serum creatinine observed in recent paricalcitol trials is a function of reduced creatinine secretion and not an actual reduction in kidney function. 16 patients will have kidney function measured via iothalamate clearance at baseline, after 7 days of paricalcitol treatment and after 7 days of being washed off the paricalcitol.


Eligibility criteria:
inclusion criteria: * age \> 18 years * stage 3 or 4 ckd * ability to give informed consent exclusion criteria: * serum calcium \> 10 g/dl * serum phosphorous \> 6 g/dl * on \> 400 units/d vitamin d therapy * receiving cimetidine, triamterene, or trimethoprim, drugs that block creatinine secretion * on vitamin d receptor activators (paricalcitol, calcitriol or zemplar) * allergic to radiocontrast dye

Keywords: chronic kidney disease vitamin d
quality improvement strategies to increase human papillomavirus (hpv) vaccination

Conditions: Human Papillomavirus Infection

Summary: hpv vaccination is at lower levels than the national goals. this study will evaluate the effectiveness of quality improvement strategies for increasing hpv vaccination coverage among adolescents in primary care clinics.

the university of north carolina will test the effectiveness of the center for disease control and prevention's afix model, physician-to-physician engagement, and both strategies in combination, for increasing hpv vaccination coverage among adolescents in primary care clinics. afix (assessment, feedback, incentives and exchange) consists of brief quality improvement consultations that immunization specialists from state health departments deliver to vaccine providers in primary care settings. using immunization registry data, the specialist evaluates the clinic's vaccination coverage and delivers education on best practices to improve coverage. physician-to-physician (p2p) engagement consists of physician educators providing feedback about clinics' current hpv vaccination coverage and in-depth training about how to make strong and effective hpv vaccination recommendations to primary care providers via remote webinar consultations. physician educators will also use immunization registry data to provide feedback on clinics' vaccine coverage. the investigators will compare changes in hpv vaccination coverage before and after intervention for high-volume primary care clinics in four study conditions: afix consultations delivered in-person by state health department immunization specialists (afix group), physician-to-physician consultations delivered remotely by trained physician educators (p2p group), both afix and p2p consultations in combination (afix + p2p group), or no hpv quality improvement intervention (control group). in each state, 30 clinics will be randomly assigned to each study arm, for a total of 120 clinics per state, or 360 clinics overall. as a secondary endpoint, we proposed to evaluate the impact of intervention "booster" visits delivered at 12-months post-intervention. however, the cdc has recently changed the afix program so that the desired comparison is no longer possible. therefore, we have eliminated booster visits. this change does not affect our primary endpoint. the primary objective of this study is to compare the change in coverage for hpv vaccine initiation among 11-12 year old patients, from baseline to 12-month follow-up. secondarily, the study will compare the change in coverage for other vaccines, age groups and time periods.

Eligibility criteria:
inclusion criteria: * pediatric or family medicine clinics or practices in new york, wisconsin, or arizona with at least 200 active records for patients, ages 11-17, in their states' immunization information systems. exclusion criteria: * less than 200 active records for patients between 11-17

Keywords: quality improvement hpv vaccine
treatment result of ktp laser nasopharyngectomy in recurrent npc patients

Conditions: Recurrent; Nasopharyngeal Carcinoma

Summary: investigate the treatment result of ktp laser nasopharyngectomy in recurrent npc patients

nasopharyngeal carcinomas (npcs) are highly radiosensitive tumors, and the primary treatment of npcs is radiotherapy.1 because most patients who have npc are at advanced stages when initially seen, local failures in terms of persistence or recurrence are not infrequent after primary radiotherapy.2,3 local regional relapse without the presence of distant failure can still be salvaged and should be aggressively treated. tumors relapsing in the nasopharynx can be salvaged using either re-irradiation or surgical techniques.1 although re-irradiation to the recurrent tumor can extent the 5-year actuarial survival rate, it is associated with high morbidity. 4-6 traditional nasopharyngectomy has been associated with local control rates on the order of 40%\~50%, but it has also been associated with complications such as palatal defects, trismus, facial scarring, osteomyelitis, etc.7-10 that is the reason why surgeons continue searching for new methods for performing nasopharyngectomies with lower morbidities. nasopharyngectomies are difficult to perform because of the inaccessibility of the nasopharynx. more difficulties are encountered in performing a nasopharyngectomy through the nose due to the restricted surgical field. with advances in techniques of endoscopy and application of the potassium-titanyl-phosphate (ktp) laser in surgery, pathologic lesions located either at the choanal margin or in the nasopharynx can easily be managed with instruments inserted via the nasal cavities. the surgical technique had been accepted by the authority journal. this time, we will review the therapeutic result of ktp-laser nasopharyngectomy in patients with recurrent npc.

Eligibility criteria:
inclusion criteria: * recurrent npc patients exclusion criteria: * patients with distant metastasis

Keywords: npc nasopharyngectomy ktp laser recurrence
global anticoagulant registry in the field

Conditions: Atrial Fibrillation

Summary: the global anticoagulant registry in the field-atrial fibrillation (garfield-af registry) is a non-interventional, observational study that characterized a global population of non-valvular atrial fibrillation patients. the registry was used to document global baseline characteristics, current treatment strategies and outcome measures. characterisation of a number of af sub-populations was also completed. garfield-af is an independent academic research initiative sponsored by the thrombosis research institute (london, uk) and supported by an unrestricted research grant from bayer ag (berlin, germany).

using data from more than 1000 randomly selected centres across 35 countries, representing all possible care settings, the registry will help to characterize real-life anticoagulant treatment patterns and outcomes, including rates of stroke and bleeding complications, as well as provide data on other important issues, such as physicians' compliance with guidelines and patients' adherence to therapy. this is particularly timely as standard practice moves away from vitamin k antagonist (vka)-dominated therapy and towards a new era of novel oral anticoagulants (oacs), i.e. direct factor xa inhibitors and direct thrombin inhibitors. to ensure a dataset that truly reflects current practice, the investigators are requested to prospectively enrol all newly diagnosed patients with non-valvular af who have at least one additional investigator-determined risk factor for stroke. patients are consecutively recruited into one of five cohorts and followed up for at least 2 years.

Eligibility criteria:
inclusion criteria: prospective cohort * written informed consent * age 18 years and older * new diagnosis of non-valvular atrial fibrillation (diagnosed within the last 6 weeks) with at least one additional risk factor for stroke and regardless of therapy. retrospective validation cohort * written informed consent * age 18 years and older * diagnosis of non-valvular af (diagnosed 6-24 months prior to enrolment) with at least one additional risk factor for stroke and regardless of therapy. exclusion criteria: * no further follow-up envisaged or possible within enrolling hospital or with associated family practitioner. * patients with transient af secondary to a reversible cause. * patients recruited in controlled clinical trials.

Keywords: atrial fibrillation anticoagulation stroke stroke prevention health economics