Kornimate/medical-research-clean huggingface dataset:
fluoroestradiol pet imaging in predicting response to hormone therapy of breast cancer

Conditions: Metastatic Breast Cancer

Summary: compare the response rate after 6 months of hormone treatment (or a major change in hormone treatment) in metastatic breast cancer, according to the uptake of fes in metastatic lesions taking-up fdg on pet/ct at baseline. hypothesis: best response rate will be observed in patients with all metastases taking up fes prior to treatment.

main objective: compare the response rate after 6 months of hormone treatment (or a major change in hormone treatment) in metastatic breast cancer, according to the uptake of fes in metastatic lesions taking-up fdg on pet/ct at baseline. secondary objectives: * evaluate diagnostic performance of fes pet/ct * determine whether fes pet/ct is able to detect metastases that are not visible on fdg pet/ct. this point may constitute a direct benefit for the patient * precise the nature of discordant fes/fdg foci * validate and improve the interpretation criteria for fes pet/ct * confirm the perfect tolerance

Eligibility criteria:
inclusion criteria: * post menopausal * age \> 17 * who 0-2 * metastatic adenocarcinoma of the breast * treated by antihormone treatment during around 5 years withdrawn for at least 3 months or metastatic cancer at diagnosis having received no more than one line of hormone treatment * life expectancy \> 6 months * hormone-dependent cancer initially demonstrated by hormone receptors in the tumour * presence of oestrogen receptors proven with immunohistochemistry (\> 10%) and her2 determined by immunohistochemistry or fish (on primary tumour or a metastasis) * metastatic recurrence on fdg pet dating less than 1 month, confirmed by another modality (contrast-enhanced ct, mri, ultrasonography, bone scintigraphy or pet/ct, other) * fdg pet/ct available on pacs or cd dicom iii format 11 * informed consent obtained exclusion criteria: * other evolutive malignant disease or acute or chronic infectious disease * chemotherapy during the last 3 months or change in treatment since fdg pet/ct. * isolated liver metastasis (high fes uptake by normal liver)

Keywords: pet/ct,fluoroestradiol (18f) breast cancer metastatic prediction of response hormone therapy
serum free amino acid concentrations in critically ill patients undergoing continuous renal replacement therapy (crrt)

Conditions: Sepsis; Amino Acid Catabolism Disorder

Summary: sepsis is a life-threatening condition associated with high morbidity and mortality. the breakdown of proteins mainly from skeletal muscles leads to the release of free amino acids (faas). the serum faa pool has been repeatedly assessed and found to be significantly altered in patients with sepsis/septic shock. sepsis is well known to be the most common factor contributing to the development of acute kidney injury in critically ill patients. the investigators want to establish the baseline profile of faas and their derivatives in patients with sepsis/septic shock undergoing continuous renal replacement therapy due to sepsis-associated acute kidney injury. secondly, the investigators want to compare the faa profiles of the survivors and nonsurvivors.


Eligibility criteria:
inclusion criteria: * over 18 years of age * present aki * requiring renal replacement therapy * hospitalized at the icu. exclusion criteria: * acute kidney disease requiring renal replacement therapy prior to admission to the icu * chronic kidney disease requiring renal replacement therapy prior to admission to the icu * history of past crrt.
developmental dyslexia and functional maturation of auditory cortex

Conditions: Developmental Reading Disorder; Dyslexia

Summary: developmental dyslexia is a frequent learning disability. the aim of this study is to compare auditory evoked cortical responses to syllables and tones in developmental dyslexia and controls (paired with age, gender). the study is conducted in 3 groups of subjects :8-10 years ; 11-17 years and 18-25 years. we suppose that cortical responses should be different in developmental dyslexia and controls.


Eligibility criteria:
inclusion criteria: age (8-10 years ; 11-17 years ; 18-25 years developmental reading disorders (developmental dyslexia) criteria according to critchley (1970) piq \> 85 no auditory deficit no psychosis - exclusion criteria: piq \< 85 epilepsy adhd stroke, head injury -
anti-helicobacter pylori antibodies (igg) in serum of women with unexplained infertility

Conditions: Infertility, Female

Summary: prevalence of anti-h.pylori igg in serum of women with unexplained infertility and comparing that with it's prevalence in fertile women.

unexplained infertility was diagnosed according to standard world health organization (who) criteria. all women in the study had hormonal assessment to evaluate their ovulatory cycles, thyroid function, circulating prolactin and androgen levels. the ovarian reserve was checked by measurement of serum fsh and an antral follicle count on the third day of the menstrual cycle. screening for infertility also included transvaginal ultrasound and hysterosalpingography, to exclude possible uterine malformations or pathologies, and to assess the patency of the fallopian tubes. male factor infertility was excluded in all couples, according to standard who semen analysis. following admission, all patients underwent complete clinical examination and detailed medical history was obtained. a venous sample was collected to test serum for hp igg seropositivity by enzyme linked immunoassay for helicobactor pylori igg (enzyme immunoassay test kit).

Eligibility criteria:
inclusion criteria: 1. regular cycles. 2. normal thyroid function, prolactin and androgen levels. 3. normal semen analysis of the partner. 4. normal hysterosalpingography. 5. normal transvaginal ultrasound examination. exclusion criteria: 1. possible uterine malformations or pathologies. 2. presence of infections, including hepatitis, human immunodeﬁciency virus (hiv), torch, chlamydia trachomatis and mycoplasma. 3. presence of anti-sperm antibodies in serum. 4. male factor infertility.
indacaterol delivered via a single dose dry powder inhaler (sddpi) in chronic obstructive pulmonary disease (copd)

Conditions: Pulmonary Disease, Chronic Obstructive; COPD; Lung Diseases, Obstructive

Summary: the study is designed to obtain safety and efficacy data on three dose levels of indacaterol when delivered via an sddpi in patients with copd. all patients will receive 1 day of treatment with each of the following: indacaterol 150 µg, once- indacaterol 300 µg, indacaterol 600 µg, placebo, and formoterol. each treatment day will be followed by a washout-period of 1 week.


Eligibility criteria:
inclusion criteria: * male and females aged 40-75 years with copd and symptoms such as cough, sputum production, and shortness of breath. * smoking history of at least 10 pack years * fev1 less than 65% of the predicted normal value and at least 0.75 l * pre-bronchodilator fev1/fvc less than 70% exclusion criteria: * a history of asthma or copd diagnosis before the age of 40 * hospitalization for copd exacerbation within the previous 6 weeks * respiratory tract infection within 6 weeks * use of long-term oxygen therapy * diabetes type i or uncontrolled diabetes type ii * clinically relevant laboratory abnormality or clinically significant condition * corrected qt interval (qtc) above 430 ms for males and 450 ms for females, or a history of qtc prolongation. other protocol-defined inclusion/exclusion criteria may apply.

Keywords: indacaterol long acting beta agonist
niv and cpap failure predictors in covid-19 associated respiratory failure

Conditions: Respiratory Failure; Covid-19

Summary: evaluate hacor socre utility and efficacy in predicting niv and/or cpap failure in patients with covid-19 associated respiratory failure. propose adaptations to hacor score based on the "state of art" of covid-19

evaluate hacor socre utility and efficacy in predicting niv and/or cpap failure in patients with covid-19 associated respiratory failure. propose adaptations to hacor score based on the "state of art" of covid-19 - this adaptations may include radiologic aggravation and monitoring of crf, ferritin, ldh, d-dimers, nt-probnp, troponin i, got, gpt, blood count

Eligibility criteria:
inclusion criteria: * patients with acute respiratory failure due to covid-19 who have initiated niv or cpap based on assistant clinician decision exclusion criteria: * patients with imediate indication to invasive mechanical ventilation * patients with any formal contraindication to noninvasive respiratory support

Keywords: noninvasive ventilation cpap covid-19 respiratory failure hacor score
phase 1/2 clinical study of hrs-4357 in patients with advanced prostate cancer

Conditions: Advanced Prostate Cancer

Summary: the study is being conducted to evaluate the the safety, pharmacokinetics, radiation dosimetry, and preliminary efficacy of hrs-4357 injection in adult patients with advanced prostate cancer.


Eligibility criteria:
inclusion criteria: 1. voluntary participation in this clinical trial, understanding of the study procedures and being able to sign the informed consent form in writing; 2. male, age ≥18 years; 3. ecog score 0 - 1; 4. histologically and/or cytologically confirmed adenocarcinoma of the prostate; exclusion criteria: 1. spinal cord compression with clinical symptoms, or clinical symptoms and/or imaging findings suggesting imminent spinal cord compression. 2. severe urinary incontinence, hydronephrosis, severe micturition dysfunction, etc. note: subjects with bladder outflow obstruction or urinary incontinence that can be controlled by the best available standard of care (including pads, drainage, etc.) are eligible to participate in the study. 3. active syphilis infection. 4. known hypersensitivity to components of the study drug or its analogues.
xylitol versus saline in chronic sinusitis

Conditions: Chronic Sinusitis

Summary: is a xylitol nasal rinse better or worse than saline on patient satisfaction.

in this pilot study, the investigators plan to compare the efficacy of twice daily xylitol nasal rinse with saline rinse which is the current standard, on outcomes such as quality of life and exacerbations.

Eligibility criteria:
we now have two arms to this study. group i: immunocompetent subjects with chronic rhinosinusitis inclusion criteria: * 56 adult subjects (18 or older) presenting to the ent(ears, nose, throat) clinics who meet the diagnosis of chronic rhinosinusitis (crs). definition of crs: presence of at least 2 of the following 4 signs/symptoms for 12 weeks or longer despite medical management: * anterior and/or posterior mucopurulent drainage * nasal obstruction * facial pain, pressure, and/or fullness * decreased sense of smell * in addition, objective evidence of sinus mucosal disease must be demonstrated on sinus ct imaging or direct endoscopic examination. exclusion criteria: * cystic fibrosis * fungal sinusitis * immunocompromised status (use of long term oral steroids (\> 30 days), aids, active malignancy or chemotherapy) * known ciliary disorders * sinonasal tumors * pregnancy group 2: crs with antibody deficiency * 56 adult subjects (18 or older) presenting to the allergy clinic who meet the diagnosis of chronic rhinosinusitis (crs). definition of crs: presence of at least 2 of the following 4 signs/symptoms for 12 weeks or longer despite medical management: * anterior and/or posterior mucopurulent drainage * nasal obstruction * facial pain, pressure, and/or fullness * decreased sense of smell * in addition, objective evidence of sinus mucosal disease must be demonstrated on sinus ct imaging or direct endoscopic examination. exclusion criteria: cystic fibrosis sinonasal tumors pregnancy

Keywords: xylitol vs. saline nasal washes sinusitis
epidemiological study to assess the prevalence of lung cancer

Conditions: Lung Cancer; Tobacco; Atherosclerotic Cardiovascular Event

Summary: lung cancer is the main cause of mortality by cancer in france. the lung cancer stage at time of diagnosis is a major determinant of survival. to date, 75% of lung cancer are diagnosed at an advanced stage with worse survival). lung cancer screening is based on low dose ct scan which allows to decrease lung cancer related mortality of 20% in patients aged 55-74 years-old with a history of tobacco consumption ≥ 30 py active of who quite \< 15 years. these criteria for eligibility for lung cancer screening lead to 1 to 2% of lung cancer diagnosis at the first ct scan. in our experience regarding 1 year of lung cancer surgical resection, only 45% of the patients presented criteria for lung cancer screening. moreover, the duration of tobacco consumption would provide a better stratification of lung cancer risk compared to only py. therefore, other criteria for lung cancer screening eligibility could be proposed. currently, 9 out of 10 lung cancer is linked with tobacco consumption which is also a major risk factor for atherosclerosis-associated cardiovascular events. around 40% of patients with a lung cancer have a history of atherosclerosis-associated cardiovascular event, mainly coronary artery diseases and peripheral artery diseases. main objective: the objective is to compare the observed rate of lung cancer prevalence in our study to the rate of around 2 % observed in lung cancer screening trials in south europe (france and italy). the investigators hypothesize that the population of patients with a history of atherosclerotic cardiovascular event associated with tobacco consumption present a higher prevalence of lung cancer compared with the population of patients eligible for lung cancer screening program which is defined by age and history of tobacco consumption.


Eligibility criteria:
inclusion criteria: * age 45 - 75 years old * patient who has signed an informed written consent * daily smoking for at least 10 years * history of cardiovascular disease: exclusion criteria: * history of active cancer \< 5 years (except in situ cervical carcinoma and basal cell carcinoma of the skin) * lung cancer symptoms (involuntary weight loss \> 6.8 kg in 1 year, hemoptysis) * treatment or bleeding risk syndrome contraindicating an invasive diagnostic procedure within 3 months. * active pulmonary parenchymal infection * severe cardiac or respiratory insufficiency (resting dyspnea)

Keywords: cancer tobacco
magnetic seizure therapy vs. electroconvulsive therapy for bipolar mania

Conditions: Bipolar Disorder, Manic

Summary: this trial attempts to evaluate the treatment efficacy of magnetic seizure therapy (mst) and its safety for bipolar mania. half of the participants will receive mst, while the other half will receive electroconvulsive therapy (ect).

magnetic seizure therapy (mst) is likely to be an alternative options to electroconvulsive therapy (ect). widespread stimulation of cortical and subcortical regions is inevitable for ect since the substantial impedance of the scalp and skull shuts most of the electrical stimulus away from the brain. nevertheless, magnetic pulses are capable to focus the stimulus to a specific area of the brain because they can pass the scalp and skull without resistance. in addition, electric current will penetrate into deeper structures, while magnetic stimulus are only capable to reach a depth of a few centimeters. as a consequence, mst are able to generate focus stimuli on superficial regions of the cortex while ect can't, which may give mst the capability to produce comparable therapeutic benefits with the absence of apparent cognitive side effects.

Eligibility criteria:
inclusion criteria: 1. dsm-5 diagnosis of bipolar i disorder and currently in a manic episode; 2. convulsive therapy clinically indicated, such as severe psychomotor excitement or retardation, attempts of suicide, being highly aggressive, pharmacotherapy intolerance, and ineffectiveness of antipsychotics; 3. the positive and negative syndrome scale (panss) score ≥ 60; 4. informed consent in written form. exclusion criteria: 1. diagnosis of other mental disorders; 2. severe physical diseases, such as stroke, heart failure, liver failure, neoplasm, and immune deficiency; 3. present with a laboratory abnormality that could impact on efficacy of treatments or safety of participants; 4. failure to respond to an adequate trial of ect lifetime; 5. are pregnant or intend to get pregnant during the study; 6. other conditions that investigators consider to be inappropriate to participate in this trial.

Keywords: magnetic seizure therapy electroconvulsive therapy bipolar mania cognition controlled trial
evaluation of al prediction for rectal cancer

Conditions: Anastomotic Leak Rectum

Summary: anastomotic leakage is one of the most serious postoperative complications of low rectal cancer, with an incidence of 3%-21%. the occurrence of anastomotic leakage is related to many factors, and the occurrence of anastomotic leakage can be predicted by building a prediction model. most of the anastomotic leakage prediction models constructed in the past are nomograms, which have limitations in the fitting of model creation. in the previous study, the center took the lead in building a random forest anastomotic leakage prediction model based on machine learning. this study intends to prospectively enroll patients with rectal cancer undergoing anterior abdominal resection and use their clinical data to prospectively verify the efficacy of the anastomotic leakage prediction model, and further improve and promote the prediction model.


Eligibility criteria:
inclusion criteria: 1. patients aged 18-75 years 2. adenocarcinoma confirmed by pathology 3. colonoscopy or imaging examination confirmed that the distance between the lower edge of the tumor and the anal edge was less than or equal to 12cm 4. preoperative imaging diagnosis was ctxnxm0 5. no local complications (no obstruction, incomplete obstruction, no massive active bleeding, no perforation, abscess formation, and no invasion of adjacent organs) 6. the hematopoietic functions of heart, lung, liver, kidney and bone marrow meet the requirements of surgery and anesthesia 7. voluntarily sign the informed consent form exclusion criteria: 1. previous history of malignant tumor 2. simultaneous multiple primary colorectal cancer 3. previous multiple abdominal and pelvic surgeries or extensive abdominal adhesions 4. patients with intestinal obstruction, intestinal perforation, intestinal bleeding, etc., requiring emergency surgery 5. patients with familial adenomatous polyposis and active inflammatory bowel disease 6. a history of severe mental illness 7. pregnant or lactating women 8. patients with uncontrolled infection before operation 9. the investigator did not consider the patient to be eligible for the trial

Keywords: anastomotic leak rectal cancer machine learning
validity of fluorescence-based devices versus visual-tactile method in detection of secondary caries around resin composite restorations: invivo diagnostic accuracy study

Conditions: Secondary Caries Around Resin Composite Restorations

Summary: this study will be conducted to evaluate the clinical performance and validity of both light-induced fluorescence intraoral camera and laser-induced fluorescence device in comparison to visual-tactile assessment method in detection of secondary caries around margins of resin composite restorations.

each patient should have at least one resin composite restoration. the restoration will be evaluated by all diagnostic methods. each examiner will independently record the dental findings using all methods, the visual- tactile assessment method and both fluorescent-aided identification methods. the visual-tactile assessment method includes the use of mirror, probe under good illumination condition, while the fluorescent-aided identification methods will be performed by both light-induced fluorescence intraoral camera and laser-induced fluorescence device. then diagnostic performance for caries detection was evaluated, assessing the validity of each diagnostic method in diagnosing secondary caries around margins of resin composite restorations

Eligibility criteria:
inclusion criteria: * patients should be over 18 years of age. * patients should have an acceptable oral hygiene level. * patients should have at least one resin composite restoration. exclusion criteria: * patients with a compromised medical history. * patients with active severe periodontal disease.
the glycemic indices of five common varieties of dates in the tested among healthy and diabetic subjects

Conditions: Diabetes Mellitus

Summary: the main objectives of this study is to measure the composition of five common types of dates (fara'd, lulu, abu ouma'n, dabbas and khalas) and to calculate their glycemic indices (gi) of these dates tested in healthy and diabetic subjects. thirteen healthy volunteers and ten subjects with type 2 diabetes mellitus were enrolled in the study. the dates' flesh composition analysis showed that the dates contain a high percentage of carbohydrate (total sugars, 65-68%). the measured mean glycemic indices of the dates among healthy individuals were 54.0, 53.5, 46.3, 49.1 and 55.1 for fara'd, lulu, abu ouma'n, dabbas and khalas, respectively. corresponding mean glycemic indices among individuals with type 2 diabetes were very similar 46.1, 43.8, 51.8, 50.2, and 53.0. thus the tested five varieties of the dates are classified as low glycemic index food items.

the united arab emirates (uae) has transitioned rapidly over the last 40 years. this has lead to a dramatic increase in the prevalence of obesity, metabolic syndrome, dyslipidaemia, hypertension, prediabetes and diabetes. daily consumption of dates is the norm.the main objectives of this study is to measure the composition of five common types of dates (fara'd, lulu, abu ouma'n, dabbas and khalas) and to calculate their glycemic indices (gi) of these dates tested equally in healthy and diabetic subjects. thirteen healthy volunteers and ten subjects with type 2 diabetes mellitus were enrolled in the study. the dates' flesh composition analysis showed that the dates contain a high percentage of carbohydrate (total sugars, 65-68%). the measured mean glycemic indices of the dates among healthy individuals were 54.0, 53.5, 46.3, 49.1 and 55.1 for fara'd, lulu, abu ouma'n, dabbas and khalas, respectively. corresponding mean glycemic indices among individuals with type 2 diabetes were very similar 46.1, 43.8, 51.8, 50.2, and 53.0. thus the tested five varieties of the dates are classified as low glycemic index food items with potential health benefits for healthy and diabetic individuals alike.

Eligibility criteria:
inclusion criteria: * adult * healthy or having controlled type 2 diabetes mellitus exclusion criteria: * morbid obesity (bmi \> 40) * presence of gastroenterological disorders * alimentary tract surgery * a history of gastroenteritis in the prior six months * any disease that may affect glucose metabolism * alcohol intake * smoking * taking any medications (except metformin) * poorly uncontrolled diabetes (hba1c \> 8%) * the presence of chronic diseases or the presence of acute illness

Keywords: glycemic index dates blood glucose