Kornimate/medical-research-clean huggingface dataset:
lilly's emotional and physical symptoms of depression study (leaps)

Conditions: Major Depressive Disorder

Summary: to assess the effectiveness of duloxetine administered once daily in patients with major depressive disorder in a practice based setting

to assess physical and emotional symptoms of depressed patients

Eligibility criteria:
inclusion criteria: * meet criteria for major depressive disorder according to the dsm-iv diagnostic criteria * outpatients at least 18 years of age * sign the informed consent * all females must test negative for a urine pregnancy test at visit 1. females of child bearing potential must agree to utilize medically acceptable and reliable means of birth control * have a level of understanding sufficient to communicate with the investigator and are able to complete all patient self-rated scales in the study exclusion criteria: * are investigator site personnel directly affiliated with the study or immediate family * are employed by eli lilly and company * have received treatment within the last 30 days or are currently enrolled in a study with a drug that has not received regulatory approval for any indication at time of study entry * current substance dependence, excluding nicotine and caffeine * treatment with a monoamine oxidase inhibitor within 14 days prior to visit 1 or potential need to use an maoi within 5 days after discontinuation of study drug * acute liver injury or severe (child-pugh class c) cirrhosis
assessment of therapeutic education about non invasive ventilation in patients with chronic respiratory failure (qovni)

Conditions: Alveolar Hypoventilation

Summary: the purpose of the study is to assess the therapeutic education of patients with chronic respiratory failure who start to be treated with non invasive ventilation and during the first six months of ventilation.

therapeutic education about non invasive ventilation in patients with chronic respiratory failure and alveolar hypoventilation is assessed during the first six months of ventilation thanks to a questionnaire. moreover, the impact of this therapeutic education on non invasive ventilation compliance, blood gas, dyspnea and nocturnal desaturation is assessed.

Eligibility criteria:
inclusion criteria: * patients with chronic respiratory failure * with alveolar hypoventilation required non invasive ventilation * adults and non-vulnerable subject * fluency in french exclusion criteria: * age under eighteen years old * patient with guardianship * no french-speaking * severe cognitive abnormalities * no criteria to introduce non invasive ventilation
advance care planning & goals of care randomized controlled trial in primary care

Conditions: Chronic Illness; Comorbidities

Summary: sometimes people with health conditions become ill suddenly and can no longer speak for themselves and another person (such as a family member) will make health care decisions for them. this means it is important for people to think about their wishes and tell others about them. this is called advance care planning. when people have done advance care planning, if they become very sick and cannot speak for themselves they are more likely to get the kind of health care they want and it is easier for the people who make decisions for them. in alberta, there is a form in the health care system that is used to indicate a person's wishes if participants are unable to speak for themselves. there are tools such as brochures, questionnaires, and videos that can help participants learn about advance care planning and serious illness conversations. this research is being done to study whether using tools for advance care planning will help improve goals of care designation completion rates in such a way that they better reflect patient values. in this project, we aim to determine the efficacy of tools to increase the quality and quantity of advance care planning (acp) and goals of care determinations (gcd) in primary care settings in alberta.

in prospective and randomized trials, advance care planning (acp) significantly improves outcomes including increased likelihood that clinicians and families understand and comply with a patient's wishes, reduces hospitalization at the end of life, results in less intensive treatments at the end of life (according to patients' wishes) and increases use of hospice services. trials have not been done in primary care. the aim of this study is to determine the efficacy of a care pathway designed to increase the quality and quantity of acp in patients and their substitute decision-makers in primary care. the study is a multi-site, patient-based, unblinded, randomized trial conducted in family practices in canada. participants will be patients who are determined by their physician to be able to benefit from acp, and the patient's substitute decision-maker. participant pairs will be randomized to immediate intervention (care pathway) or delayed (8-12 weeks). the intervention is guided use of tools and decision aids to clarify values and preferences for treatments in the event of serious illness or near end of life. the outcomes will be presence of a goals of care form in the chart, substitute decision-maker engagement in acp (including self-efficacy for enacting the role), patient engagement in acp, and decisional conflict.

Eligibility criteria:
inclusion criteria: * age 65 years or older * have at least one chronic condition that may be life-limiting exclusion criteria: * unable to communicate with an english-speaking research coordinator
probiotics for birch pollen allergy

Conditions: Rhinitis, Allergic, Seasonal

Summary: birch pollen allergy is one of the most common forms of respiratory allergy in the nordic countries. treatment consists of antihistamine use. specific probiotic strains have been observed to modulate the immune system. since the body has a common mucosal immune system; it was hypothesised that consumption of probiotics may affect also the respiratory mucosal immune response and hence affect respiratory allergy. earlier studies with probiotics had been unable to show improvements in adults with pollen allergy. it was therefore hypothesised that children, who's immune system is not yet fully developed, might be better targets.


Eligibility criteria:
inclusion criteria: physician verified birch pollen allergy exclusion criteria: diagnosed asthma habitual use of probiotics and/or prebiotics

Keywords: birch pollen
efficiency of diagnostic strategy for fast track lung cancer diagnosis

Conditions: Lung Cancer

Summary: annually, 4,200 new cases of lung cancer are diagnosed in denmark. the stage of the disease is an important prognostic factor as an advanced stage reduces the opportunity for surgical intervention and other curative treatment. in denmark, as in many other countries, a fast track evaluation for lung cancer has been introduced in 2008. when the general practitioners refer patients through the fast track, the majority of patients make their first visit to the department of pulmonary medicine. after this visit, further investigation is initiated, which is often a ct scan of the chest and the upper abdomen. we dont know whether this is the most appropriate organisation. the aim of this project is to evaluate the way lung cancer patients are examined through the fast track and the impact of chest ct before an evaluation by a chest physician. investigators want to randomise all patients referred for the existing fast track to either direct ct scan of chest and upper abdomen or to evaluation by the chest physician, in order to test: a) fast track performance measured by number of ct scans and chest physician specialist time per diagnosis, and whether there is a difference between the intervention and the control group.


Eligibility criteria:
inclusion criteria: * all patients referred to fast track evaluation (lung department, aarhus university hospital) from primary care. exclusion criteria: * not referred from general practice

Keywords: organization of fast track
protective effect of intraoperative parathyroid gland auxiliary recognition system in thyroid malignant tumor operation

Conditions: Parathyroid; Intraoperative Monitoring; Thyroid Cancer

Summary: this intraoperative parathyroid gland auxiliary recognition system uses the principle of parathyroid gland autofluorescence to assist surgeons in accurately identifying and protecting parathyroid glands during surgery, reducing the possibility of postoperative hypoparathyroidism. this study will explore the protective effect of the parathyroid gland auxiliary recognition instrument on parathyroid function during thyroid malignant tumor surgery through reasonable grouping.


Eligibility criteria:
inclusion criteria: 1. patients with unilateral thyroid malignancies who require surgical treatment between the ages of 20-50. 2. no history of neck surgery and radiotherapy. 3. there is no evidence of parathyroid tumor invasion in preoperative imaging assessment. 4. no abnormal calcium metabolism disease. 5. no abnormalities in blood calcium and blood pth before operation. 6. no allergy to contrast agents. 7. the patient or his agent signs an informed consent statement. exclusion criteria: 1. does not meet the entry criteria; 2. parathyroid glands were found to be invaded by tumor during operation and the parathyroid glands could not be preserved.
application of biomarkers in neurological diseases

Conditions: Biomarkers

Summary: to explore the predictive and diagnostic role of biomarkers in patients with neurological diseases.

with the rise and continuous development of omics technology and bioinformatics technology, some scholars have applied proteomics technology and metabolomics technology to study the brain tissue, plasma and csf of patients with nervous system diseases, so as to screen out potential biomarkers, with a view to providing new research ideas for pathogenesis and early diagnosis of neurological diseases. at present, the research on some novel biomarkers is still in its infancy, and many key problems remain to be solved. it is necessary to further determine the expression level of biomarkers in normal human body and the characteristics of biomarkers in patients with neurological diseases.

Eligibility criteria:
inclusion criteria: 1. patients with neurological diseases; 2. subjects or legal agents agree to participate in the study and sign the informed consent. exclusion criteria: 1. participating in other clinical investigators; 2. unwilling to be followed up or poor treatment compliance; 3. other conditions considered unsuitable for inclusion by the researchers.
efficacy of oral exercise training in oral frailty

Conditions: Elderly (People Aged 65 or More); Swallowing Training on Muscle Strength; Dysphagia

Summary: as the elderly grow older, the quality and function of skeletal muscle are affected. sarcopenia is commonly seen in the elderly, due to the loss of skeletal muscle mass and function, often resulting in loss of activity and weight. oral frailty refers to the status of oral function decline. several studies indicate the relationship between sarcopenia and oral frailty, which is assumed to be the predictor of sarcopenia. oral frailty may also progress to presbyphagia over time, causing higher risk of malnutrition, dehydration, pneumonia, and poor quality of life. in addition, recently, the use of ultrasound can measure the distance and speed of the hyoid bone displacement, thus more clearly assessing the swallowing function. the investigators aim to analyze whether oral exercise training can promote the oral and swallowing performance of the residents with oral frailty, and the feasibility of ultrasound as swallowing function evaluation. the investigators' study will enroll participants from residential long-term care facilities according to the screening of oral frailty. the participants will be equally arranged to experimental and control groups. the intervention strategies will be given after institutional education training. oral exercise training will be performed by facility's primary caregiver with professionals' remote supervision for 12 weeks. evaluation tools include hand grip strength, 6-meter walking test, body composition analysis check (bia), repeated saliva swallowing test, eating dysfunction scale (eat-10), functional oral intake scale (fois), quality of life questionnaires, tongue muscle strength test and ultrasound swallowing function test.


Eligibility criteria:
inclusion criteria: * age 65 years or older * currently consuming food orally exclusion criteria: * previously diagnosed with dysphagia * progressive central nervous system or motor disorders (e.g., dementia, parkinson's disease) * new-onset central nervous system disease within the past 6 months (e.g., stroke, traumatic brain injury) * new-onset head and neck cancer within the past 6 months

Keywords: oral frailty oral exercise training ultrasound
defining the potency of dtg/3tc for suppressed hiv patients in real-life: the dualing study

Conditions: Hiv

Summary: this study aims to determine real-life clinical efficacy of virally suppressed patienst switching to dtg/3tc compared to dtg triple drug cart controls

dolutegravir (dtg) based dual antiretroviral therapy constitutes a paradigm shift from triple drug based therapy. data outside clinical trials are scarce. this study evaluates the value of dtg/3tc in real life.

Eligibility criteria:
inclusion criteria: plasma hivrna \<50c/ml on triple drug cart regimen including 2nrti in care in a hiv treatment center in the netherlands consented to athena participation exclusion criteria: documented mutations associated with 3tc or dtg resistance of at least low level documented inadherence by the treating physician or hepb coinfection (cases only)
reflow medical wingman catheter wing-it clinical trial

Conditions: Chronic Total Occlusion of Artery of the Extremities

Summary: to evaluate the safety and effectiveness of the reflow medical wingman catheter used to cross de novo or restenotic infrainguinal ctos that cannot be crossed with a standard guidewire.

prospective, multi-center, non-randomized single-arm study of the wingman catheter to cross a single infrainguinal peripheral chronic total occlusion (cto). safety and effectiveness will be evaluated during the index procedure through 30-day follow-up.

Eligibility criteria:
inclusion criteria: * patient is willing and able to provide informed consent. * patient is willing and able to comply with the study protocol. * patient is \> 18 years old. * patient has peripheral arterial disease requiring revascularization as evidenced by contrast, ct or mr angiography. * patient has at least one but not more than two occluded infrainguinal arteries that are 99-100% stenosed and no flow is observed in the distal lesion except the flow from collateral circulation. * target lesion(s) is ≥ 1 cm and \< 30 cm in length by visual estimate. * target vessel is ≥ 2.0 mm in diameter. * patient has rutherford classification of 2-5. * lesion cannot be crossed by concurrent conventional guidewire. * reconstitution of vessel at least 2cm above bifurcation/trifurcation. * occlusion can be within previously implanted stent. exclusion criteria: * patient has a known sensitivity or allergy to contrast materials that cannot be adequately pre-treated. * patient has a known sensitivity or allergy to all anti-platelet medications. * patient is pregnant or lactating. * patient has a co-existing disease or medical condition contraindicating percutaneous intervention. * target lesion is in a bypass graft. * patient has had a failed crossing attempt without an intervening intervention on the target limb within the past 14 days. * patient has a planned surgical or interventional procedure within 30 days after the study procedure.
the diagnostic and prognostic value of tat, pic, tpai·c and tm in sepsis-induced coagulopathy

Conditions: Sepsis-induced Coagulopathy

Summary: in order to evaluate the diagnostic and prognostic value of thrombin-antithrombin complex（tat）, α2-plasmin inhibitor-plasmin complex（pic）, tissue plasminogen activator-inhibitor complex（tpai·c） and thrombomodulin（tm） in sepsis-induced coagulopathy(sic), hospitalized patients with sepsis were prospectively included. plasma tat, pic, tpai·c,tm levels within 24 h after sepsis diagnosis were detected by mcl60 chemiluminescence analyzer. according to the sic score (≥4), they were divided into sic group and non-sic group, and roc curve analysis was performed according to the biomarker test results.

thrombin-antithrombin complex（tat）, α2-plasmin inhibitor-plasmin complex（pic）, tissue plasminogen activator-inhibitor complex（tpai·c） and thrombomodulin（tm） can evaluate vascular endothelial damage, thrombin and plasminase activation, and have clinical significance in early diagnosis of dic, thrombotic disease and monitoring of thrombolysis efficacy. however, whether these biomarkers can be used for early diagnosis of sic is unclear. in order to evaluate the diagnostic value of tat, pic, tpai·c and tm in sepsis-induced coagulopathy(sic), hospitalized patients with sepsis were prospectively included. plasma tat, pic, tpai·c,tm levels within 24 h after sepsis diagnosis were detected by mcl60 chemiluminescence analyzer. according to the sic score (≥4), they were divided into sic group and non-sic group, and receiver operator characteristic（roc） curve analysis was performed according to the biomarker test results. the area under the curve(auc) was used to determine whether tat, pic, tpai·c and tm could be used as biomarkers for sic diagnosis. if auc is between 0.7 and 0.9, this indicator has diagnostic value.

Eligibility criteria:
inclusion criteria: * septic patients who meet the diagnostic criteria of sepsis 3.0. exclusion criteria: * age \< 18 years old, heparin induced thrombocytopenia, thrombotic thrombocytopenic purpura, antiphospholipid syndrome or liver cirrhosis classified as child-pugh grade c and patients with a current treatment that interfered with coagulation (anticoagulants).

Keywords: sepsis-induced coagulopathy biomarker diagnostic value
a delphi survey for key stakeholders to identify priority self-management outcomes for chronic kidney disease

Conditions: Chronic Kidney Diseases

Summary: the purpose of this delphi study is to identify priority outcomes for self-management in earlier (non-dialysis) stages of ckd from the perspectives of different stakeholder groups in the uk. the findings of this study will be used to inform outcome measure selection for research and clinical evaluations of self-management resources and to support implementation, commissioning and uptake.

chronic kidney disease (ckd) is a progressive condition affecting more than 1.8 million people in england effective self-management is important for people living with ckd like many long-term conditions. self-management in its broadest term can be summarised as individuals participating in the day-to-day management of their chronic condition theory- and evidence-based tools and resources for self-management education and support are required to encourage health-promoting behaviours. however, outcomes valued by key stakeholders are necessary to ensure robust evaluation in research settings and clinical practice a delphi study is carried out to generate consensus on outcomes that are valued by the stakeholder groups in this study. the delphi study will undergo 3-4 survey rounds adult ckd patient participants living in the uk and their significant others were recruited via social media adverts shared by our research team and english kidney community organisations. healthcare professionals, commissioners and policymakers (professional groups) based in the uk were recruited by direct email invitations to our extensive contacts in the field

Eligibility criteria:
inclusion criteria: * people with diagnosis of ckd in the uk * their close family and friend * healthcare professionals who look after people with ckd in the uk * anyone involved in designing, developing, managing and commissioning ckd healthcare services in the uk * researchers related in a topic related to self-management or ckd exclusion criteria: * any participant residing outside of the uk

Keywords: survey chronic kidney disease stakeholder
the relationship between post-ercp-choledocholithiasis and gallbladder status

Conditions: Cholecystitis

Summary: in this retrospective study, the investigators evaluate the relationship of post-ercp-choledocholithiasis(pec ) and the gallbladder status as a risk factor.

when patients have common bile duct(cbd) stones, ercp is widely used for stone extraction instead of clinical operation. ercp has many advantages like less injury or faster recovery. however, according to literature, ercp will has a mostly 10% possibility to get an acute purulent cholecystitis, which often requires emergency intervention, therefore, it is necessary to know if the gallbladder status(chronic disease) is one of the important risk factors of pec like the gallbladder wall thickness, chronic cholecystitis, polyps,crudely or calculus. .

Eligibility criteria:
inclusion criteria: * routine ercp for cbd stone patients with gallbladder in situ exclusion criteria: * unwillingness or inability to consent for the study * unstable vital signs coagulation dysfunction (inr\>1.5) and low peripheral blood platelet count (\<50×10 \^9 / l) or using anti-coagulation drugs * any prior surgery for cbd including ercp * preoperative coexistent diseases: acute pancreatitis, gi tract hemorrhage, severe liver disease (such as decompensated liver cirrhosis, liver failure and so on), septic shock * biliary- duodenal fistula confirmed during ercp * pregnant women or breastfeeding

Keywords: ercp acute purulent cholecystitis bile duct stone pec(post-ercp-choledocholithiasis)