Kornimate/medical-research-clean huggingface dataset:
clinical outcomes of autologous bone marrow aspirate concentrate injections for musculoskeletal conditions

Conditions: Musculoskeletal Pain; Osteoarthritis; Tendinopathy; Sprains Strain

Summary: the use of bone marrow autologous collection (bmac) in musculoskeletal conditions including osteoarthritis and tendon injuries has been growing. outcome evidence continues to be sparse. the purpose of this study is collect a longitudinal case series of patient reported outcomes following bmac injections for musculoskeletal conditions including osteoarthritis, tendinopathy and injuries to ligaments, tendons and muscles.


Eligibility criteria:
inclusion criteria: * musculoskeletal condition that is able to undergo an injection * patient requests the procedure and enrolls with agreement to pay for the procedure exclusion criteria: * active cancer * allergies to local anesthesia
enhancing oral cancer awareness among minorities

Conditions: Oral Cancer; Chatbot; Patient Education; Prevention; Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer; Oropharyngeal Cancers

Summary: to evaluate the impact of ai-powered chatbot interactions versus traditional educational handouts on increasing participants' knowledge of oral cancer and its prevention

the study evaluates the difference in outcome of two distinct interventions aimed at enhancing oral cancer awareness and prevention among participants from african american communities in the richmond area. participants assigned to the first intervention arm will receive traditional educational handouts sourced from trustworthy and reliable health sources such as the cdc, american cancer association (aca), and other health education resources. these handouts will be provided to the participants and provided enough time to read them based on calculated reading time, focusing on increasing awareness of oral cancer risks, preventive strategies, and the importance of regular dental check-ups. participants assigned to the second intervention arm will engage with an ai-powered chatbot designed specifically for oral cancer education. the chatbot interaction will be initiated through a provided link, allowing participants to access information and ask questions related to oral health and cancer prevention. the chatbot is programmed to provide accurate information on oral cancer risks, symptoms, preventive measures, and the importance of regular dental check-ups

Eligibility criteria:
inclusion criteria: * identify as african american as defined by the us census * participants must be able to read, speak, and write in english exclusion criteria: * individuals who cannot physically or mentally participate in the research project will be excluded * adults unable to consent * individuals who are not yet adults (infants, children, teenagers) * prisoners

Keywords: ai-powered chatbox oral cancer prevention socio-economic barriers
chronic liver disease and radiation-induced second primary liver malignancy

Conditions: Chronic Liver Disease (CLD); Cancer; Liver Fibrosis

Summary: cancer survivors are at a high risk to develop second primary malignancy (spm) which constitutes a serious threat for them. radiotherapy is the cornerstone for the management of many cancers as a locoregional treatment modality. due to the low liver tolerance, cirrhotic patients are at a high risk of developing radiation-induced liver toxicities despite the modern safe radiation delivery techniques. radiation damages cells through direct energy deposition and reactive free radical generation. recent studies demonstrated a potential risk of spms following radiotherapy with further investigations for strategies to decrease radiation-induced spms. however, it is insufficiently addressed if developing liver spms is a serious adverse event following radiotherapy for cirrhotic patients. the aim of this study was to quantitatively assess the risk of gastrointestinal (gi) and liver spms following radiotherapy in patients with chronic liver disease.

the seer.stat software version 8.4.3 was used to obtain and analyze the data of patients with chronic liver disease diagnosed from 2010 to 2021. using ishak fibrosis score: f0-4 no to moderate fibrosis and f5-6 advanced or severe cirrhosis. patients were subgrouped according to the history of receiving radiotherapy for prior cancer treatment in two groups and excluded patients with unknown radiotherapy administration history. an mp-sir session was used to calculate the standardized incidence ratio (sir) as observed/expected (o/e) with 95% confidence interval (ci). significance was achieved at 0.05.

Eligibility criteria:
inclusion criteria: * cancer patients were classified according to fibrosis severity using the ishak fibrosis score: f0-f4 (no to moderate fibrosis) and f5-f6 (advanced or severe cirrhosis) from 2010 to 2021. exclusion criteria: * patients with unknown radiotherapy history or unknown fibrosis score or missing age data

Keywords: chronic liver seer liver fibrosis ishak score
machine learning based-personalized prediction of sperm retrieval success rate

Conditions: Infertility, Male; Azoospermia, Nonobstructive

Summary: non-obstructive azoospermia (noa) stands as the most severe form of male infertility. however, due to the diverse nature of testis focal spermatogenesis in noa patients, accurately assessing the sperm retrieval rate (srr) becomes challenging. the current study aims to develop and validate a noninvasive evaluation system based on machine learning, which can effectively estimate the srr for noa patients. in single-center investigation, noa patients who underwent microdissection testicular sperm extraction (micro-tese) were enrolled: (1) 2,438 patients from january 2016 to december 2022, and (2) 174 patients from january 2023 to may 2023 (as an additional validation cohort). the clinical features of participants were used to train, test and validate the machine learning models. various evaluation metrics including area under the roc (auc), accuracy, etc. were used to evaluate the predictive performance of 8 machine learning models.


Eligibility criteria:
inclusion criteria: * diagnosed with nonobstructive azoospermia * underwent microdissection testicular sperm extraction exclusion criteria: * without intact clinical information * low data quality

Keywords: machine learning predictive model sperm retrieval
acute kidney injury after elective total joint arthroplasty

Conditions: Acute Kidney Injury

Summary: total joint arthroplasty (tja) is a common orthopedic procedure to treat patients with end-stage knee arthritis. over 4,000 tja were performed in the hong kong public hospitals in the past 12 months (july 2020 - june 2021) and the demand for this procedure is ever increasing with time. tja are rehabilitative surgeries with an aim to accelerate patient ambulation and minimize hospital stay. to facilitate this process, multi-disciplinary enhanced recovery after surgery (eras) programs are implemented. this involves surgeons, anaesthetists, physiotherapists and nurses who follow an integrated care pathway to allow early patient mobilization and hospital discharge. the program reduces the hospital length of stay and this can reduce the risk of complications and mortality. one of the major challenges in tja is postoperative pain. tja is a very painful procedure with up to 50% of patients have moderate to severe pain (numeric rating scale \>4) immediately after surgery. this can delay patient mobilization and hinder postoperative recovery. severe postoperative pain is also associated with an increased risk of infection, myocardial ischaemia, respiratory complications and the development of chronic pain. therefore, an effective multimodal analgesia is an essential component in the eras program. it combines different oral analgesics to limit opioid use and its related side effects. celecoxib has been shown to reduce pain and opioid use after tja. it is therefore recommended to be used routinely. however, its potential nephrotoxic property has led to its judicious use, especially in patients with preoperative chronic renal failure. postoperative acute kidney injury (aki) is an independent risk factor for mortality, cardiovascular complications and hospital length of stay6. however, the studies assessing the incidence of aki following tja are scarce, and with conflicting results. therefore, the aim of our study is to retrospectively review the incidence and duration of aki following elective tja in a tertiary institution. we will evaluate the effect of celecoxib in our multimodal analgesia regimen on the risk of postoperative aki and determine the risk factors associated.


Eligibility criteria:
inclusion criteria: * patients data in our database who underwent elective primary and revision tja in queen mary hospital, hong kong from from january 2018 to december 2021. exclusion criteria: * patients with rheumatoid arthritis. * missing of essential data.
daily avanafil for erectile dysfunction

Conditions: Erectile Dysfunction

Summary: in this study, the investigators tried to study the effect of daily avanafil on the serum level of endothelial function markers, as well as its impact on the erectile function in males with erectile and endothelial dysfunction by comparing the results with controls who received placebo.

avanafil is a highly selective and potent oral phosphodiesterase type 5 inhibitor (pde5-i) . however, its impact on the soluble markers of endothelial function has not been investigated yet. this study was conducted to assess the effect of daily avanafil on the erectile function and endothelial markers' serum level. in this work we recruited males with erectile dysfunction and other diseases commonly associated with endothelial dysfunction. the investigators randomly treated patients with daily oral avanafil and the other patients with placebo. the investigators measured the international index of erectile function -5 score (iief- 5) and the serum levels of markers of endothelial function at baseline and treatment.

Eligibility criteria:
inclusion criteria: * men with clinical diagnosis of erectile dysfunction of any severity. * should be associated with systemic disorders indicative of endothelial dysfunction exclusion criteria: - erectile dysfunction due to psychogenic causes, hypogonadism, or spinal cord injury.

Keywords: erectile dysfunction endothelial dysfunction avanafil
effectiveness of radiofrequency ablation and stabilization in metastatic spine lesions by pet confirmation

Conditions: Bone Cancer Metastatic; Radiofrequency Ablation; Spine Metastases; Vertebral Metastasis

Summary: this pilot study will try to demonstrate metabolic changes in spine lesions treated by augmentation and ablation, according to existing standards of practice. our purpose is to show the efficacy of a new radiofrequency radioablation (rfa) in combination with augmentation, using a percutaneous ablation device (osteocool-medtronic) in the treatment of secondary vertebral bone tumor, avoiding concurrent bias related to other treatments of the disease.

only patient supposed to undergo percutaneous vertebral augmentation for secondary osteolytic and mixed (lytic and sclerotic) spine tumors with one to three active lesions will be enrolled. lesions to be treated must be metabolically active on pet-ct, performed during the last month. patients will be informed and sign and inform consent. patients will be treated with augmentation and ablation (osteocool-medtronic). post treatment patients will be submitted to a new pet-ct in order to verify activity on treated site.

Eligibility criteria:
inclusion criteria: * only patients with secondary osteolytic and mixed (lytic and sclerotic) spine tumors with one to three active lesions will be enrolled. * lesions to be treated must be metabolically active on pet-ct performed during the last month. * patients will be informed and sould sign an inform consent. * post treatment patients should submittes a new pet-ct in order to verify the activity of the treated area. exclusion criteria: -
carotid plaque imaging project (cpip)

Conditions: Atherosclerosis; Atherosclerotic Plaque

Summary: the rupture or erosion of an atherosclerotic plaque with thrombosis or embolization often underlie heart attacks and strokes. the early identification of patients with atherosclerotic plaques prone to rupture or erosions, vulnerable plaques (vp), and their treatment before the occurrence of events is, therefore, one of the greatest cardiovascular challenges today. possible approaches for early detection of vp include imaging techniques allowing visualization of plaque structure, circulating biomarkers and better understanding of the pathophysiologic mechanisms of the disease. in the carotid plaque imaging project the investigators study human atherosclerotic plaques (that are removed by endarterectomy) to disclose their underlying structure and mechanisms, finding possible novel therapeutic targets or markers for vp. the investigators also study plaque structure with imaging methods and try to develop new ways to detect vp using circulating or imaging markers.


Eligibility criteria:
inclusion criteria: * patients older than 18 years old, male or female that are eligible for carotid endarterectomy due to atherosclerosis and that can provide informed consent. exclusion criteria: * patients younger than 18 years old that cannot provide informed consent; pregnant.
pilot project of health promotion for people with diabetes

Conditions: Diabetes

Summary: limited participation in health promotion activities is noted in people with diabetes, even though lifestyle changes have been found to be essential in decreasing the risk of complications of the disease. the purpose of this study is to gather preliminary data to assess the feasibility of an intense, customized health promotion program in people with diabetes, and to evaluate outcome measures following participation to determine effect size for future studies. subjects with type 2 diabetes will participate in a 10-week health promotion program, at a frequency of 3-4 days per week. the intervention will include aerobic and strength training exercises with a schedule of progression, individual nutrition counseling, and diabetes health education sessions.


Eligibility criteria:
inclusion criteria: 1. diabetes type ii 2. age 40-70 exclusion criteria: 1. hospitalization for myocardial infarction, heart surgery, or congestive heart failure during the preceding 3 months 2. significant cardiac arrythmia, hypertrophic cardiomyopathy, severe aortic stenosis, or pulmonary embolus 3. recent symptoms of chest discomfort 4. currently smoking or significant pulmonary pathology 5. serious musculoskeletal problems that would limit ability to exercise 6. current active involvement in a regular exercise program (\> 3 times per week) 7. open wounds on the weight bearing surface of the feet 8. not able to ambulate independently 9. stroke or other central nervous system pathology 10. stage 2 hypertension (resting blood pressure \> 160 systolic or \> 100 diastolic)

Keywords: diabetes
prospective research for elderly (≥65 years old) early breast cancer patients

Conditions: Breast Cancer Female

Summary: the elderly patients over 65 years old with breast cancer have concomitant diseases, poor tolerance to conventional treatment, and the specific prognosis of breast cancer is relatively good. previous studies on breast cancer have almost excluded elderly breast cancer patients, and conventional treatment schemes cannot meet the clinical diagnosis and treatment needs of elderly breast cancer patients. the establishment of a prognosis model for elderly breast cancer patients can provide personalized treatment programs. this is important for prolonging the survival time of patients and improving the quality of life. this project plans to observe the relationship between prognosis and pathological staging, molecular typing, and concomitant diseases of elderly breast cancer patients in combination with immune genes, and establish a prognosis model of elderly breast cancer and verify it. this project is expected to establish a new prognostic model for elderly breast cancer patients, accurately judge the prognosis of patients, and provide a new basis for hierarchical and personalized treatment of elderly breast cancer.


Eligibility criteria:
inclusion criteria: * female patients with breast cancer * ≥65 years old * patients with breast cancer received operation in peking union medical college hospital * treatment regimen was made in peking union medical college hospital exclusion criteria: * patients with metastasis * patietns with recurrence * patients without pathological information

Keywords: ≥65 years old early breast cancer
the effect of laparoscopic splenectomy and azygoportal disconnection on the immune function for cirrhosis patients

Conditions: Cirrhosis, Liver; Splenectomy; Status

Summary: in this study, the investigators compared the improvement of immune function related indicators in patients with liver cirrhosis after laparoscopic splenectomy and azygoportal disconnection. to determine whether surgical treatment can help enhance postoperative immune function and improve patient prognosis.

the patients were enrolled according to the research criteria, and collected the general basic information of the patients. after the preoperative preparation was perfected, the same surgical team performed laparoscopic splenectomy and azygoportal disconnection, and the same nursing team performed the nursing after the operation. then, patients received a unified treatment plan after surgery, including medication, other treatments and follow-up. during the treatment, the immune function related indicators of the patients were monitored before surgery, 3, 6, 12 and 24 months after surgery, including the counts of leukocytes, neutrophils, lymphocytes, and monocytes, and the levels of cd4+,cd8+,cd4+/cd8+, and cd19,cd20.

Eligibility criteria:
inclusion criteria: * a clinical, radiological or histologic diagnosis of cirrhosis of any etiology * splenomegaly with secondary hypersplenism * gastroesophageal variceal bleeding * informed consent to participate in the study exclusion criteria: * hepatocellular carcinoma or any other malignancy, * child-pugh grade c * recent peptic ulcer disease * history of hemorrhagic stroke * pregnancy. * uncontrolled hypertension * human immunodeficiency virus (hiv) infection

Keywords: cirrhosis splenectomy laparoscopy immune function azygoportal disconnection
lucentis for age-related macular degeneration pigment epithelial detachments

Conditions: Age-related Macular Degeneration; Pigment Epithelial Detachment; Neovascular Macular Degeneration; Wet Macular Degeneration

Summary: patients with neovascular age-related macular degeneration (amd) and the particular feature of pigment epithelial detachments (peds) were not studied in the phase iii trials for ranibizumab (lucentis). the pronto study was the first ranibizumab study to enroll such patients but only treated with ranibizumab until fluid within the layers of the retina was absent, not until the entire ped was absent. this study hypothesizes that there may be a difference in benefit between patients treated until just the retinal edema is gone and those in which the retinal edema and ped are both gone.


Eligibility criteria:
inclusion criteria: * neovascular age-related macular degeneration patients over age 50 * presence of a pigment epithelial detachment on optical coherence tomography * initial or recurrent disease * previous treatment allowed * visual acuity between snellen 20/40 - 20/400 exclusion criteria: * more than three previous treatments with pdt or other radiation/laser therapy * previous vitrectomy or other amd surgical intervention * severe scarring or severe concurrent ocular disease (uncontrolled glaucoma) patients eligible for the study are randomized into one of two groups. group 1 receives injections of ranibizumab until retinal edema is resolved. group 2 receives ranibizumab injections until both retinal edema and the ped are resolved. study duration is one year with visits once per month.

Keywords: ranibizumab lucentis pigment epithelial detachment macular degeneration pronto
tenelia triple combination study

Conditions: Type 2 Diabetes Mellitus

Summary: after a screening, a 2-week, single-blind placebo run-in, 200 patients will be randomized in a 1 : 1 ratio to the addition of either once-daily teneligliptin 20mg or sitagliptin 100mg to ongoing stable doses of glimepiride in combination with metformin for 24 weeks.

subjects will visit the centers on week 4, 12 and 24 during the entire 24-week treatment period. total study duration will be approximately 28weeks and the subjects will be to practice exercise/diet control together.

Eligibility criteria:
inclusion criteria: 1. patients with type 2 diabetes mellitus 2. adults aged ≥ 19 years old 3. patients with hba1c 7%\~11% at screening and run-in visit exclusion criteria: -
genetic analysis to evaluate the racial difference in the outcome of patients with colon cancer

Conditions: Colon Cancer

Summary: this is a retrospective genetic analysis of stored tumor tissue samples to evaluate the distribution of recurrence score® and gene groups of stage ii colon cancer in african american (aa) and caucasian individuals. other covariant factors in the medical chart will be analyzed as well. three institutions will contribute patients to this study with a total patient number goal of approximately 200 with approximately 100 being aa and approximately 100 being caucasian. as enrollment in this study proceeds a caucasian subject will be matched for every african american enrolled.


Eligibility criteria:
inclusion criteria: * subjects must be 18 years of age or older. * subjects must be aa or caucasian. * subjects with pathologic stage ii colon cancer; irrespective of number of nodes examined. exclusion criteria: * patients of races other than aa or caucasian. * no tumor block available from initial diagnosis. * no tumor or very little tumor (\<5% tumor present) in block as assessed by examination of the h\&e slide by the genomic health, inc (ghi) - designated pathologist. * tumor types other than adenocarcinoma nos (not otherwise specified) and mucinous carcinoma as assessed by examination of the h\&e slide by the ghi-designated pathologist. * insufficient rna (\<5 ng/μl or 300 ng) for rt-pcr (radiation therapy - pathologic complete response) analysis. * failure of assay to meet pre-specified quality control (qc) specifications.