Kornimate/medical-research-clean huggingface dataset:
novel mri techniques for the characterization and treatment assessment of high grade brain lesions

Conditions: Brain Neoplasm; Lymphoma; Metastatic Malignant Neoplasm in the Brain; Recurrent Malignant Brain Neoplasm

Summary: this trial studies different magnetic resonance imaging (mri) techniques and their ability to provide clearer pictures of lesions in patients with high grade brain lesions. an mri is a type of imaging scan. using different mri techniques to produce clearer images of the brain may help researchers learn about the features of brain lesions and the effects of chemotherapy and/or radiation therapy.

primary objectives: i. to use 3-dimensional (3d) quantitative mapping to determine whether differences in t2 spin parameters exist between the peritumoral area and normal brain in the contralateral hemisphere at baseline. ii. to use 3d quantitative mapping to examine how differences between peritumoral and normal brain in the contralateral hemisphere change before and after treatment. secondary objectives: i. determine whether t2 values might be useful in distinguishing non-enhancing components of the tumor as well as predicting response to treatment. ii. quantify t1 and proton density (pd) spin parameters of the peritumoral area and their differences before and after treatment. iii. examine post-contrast t1 spin parameters with perfusion characteristics as measured by an established dynamic susceptibility contrast (dsc) technique. iv. examine differences in measured perfusion parameters (blood volume and mean transit time of each tumor) before and after treatment. outline: within 21 days before standard of care chemotherapy and/or radiation therapy, patients undergo an mri scan for the first set of images. patients then receive either gadobutrol or gadobenate dimeglumine intravenously (iv) and undergo an mri for the second set of images. all mri scans take a total of 60 minutes to complete. patients then repeat the mri scans 120 days after standard of care chemotherapy and/or radiation therapy.

Eligibility criteria:
inclusion criteria: * at least one enhancing lesion, aggregate of enhancing foci, and nonenhancing lesion measuring at least 1 cm in size and is suspected to be a high grade brain neoplasm * patient is dispositioned to surgery, chemotherapy and/or radiation therapy * patient is able to understand and give own consent to participate in the study exclusion criteria: * contraindication to magnetic resonance imaging (mri) as assessed by our standard of care magnetic resonance (mr) screening procedure, which includes implants or devices that are unsafe in the magnetic environment * contraindication or history of allergy to gadolinium-based (gadobutrol \[gadovist\], gadobenate dimeglumine (multihance\]) intravenous contrast * verbal confirmation of pregnancy or a positive pregnancy test result in patient record * prior partial (greater than 50%) or gross total resection of primary tumor * prior chemotherapy or radiation treatment to brain
percutaneous discectomy to treat symptomatic lumbar disc herniation : evaluation of clinical efficiency, patient reported outcomes and economical impact by assessing time before return to work and duration of hospitalization stay

Conditions: Lumbar Disc Herniation

Summary: this study aims to evaluate the clinical (pain) and functional (patient reported outcomes) efficacy of percutaneous discectomies under ct guidance to treat lumbar disc herniations resistant to conservative treatment and nerve root infiltrations. the aim is also to evaluate the economic impact of the procedure, mainly through the length of hospitalization and the time to return to work. patients were evaluated initially before surgery and then at 1, 3 and 6 months.


Eligibility criteria:
inclusion criteria: * radiculalgia related to lumbar disc herniation with clinical radiological concordance * age \> 18 * resistance to conservative treatment and nerve root infiltrations exclusion criteria: * prior discal surgery at the same level, * lumbar canal stenosis, * extruded discal herniation, * neurological deficit, * no capacity to answer to follow-up calls
patient factors impacting adherence to oral chemotherapy

Conditions: Breast Cancer; Gastrointestinal Cancer

Summary: the purpose of this study is to identify what makes it easier and what makes it harder to take oral chemotherapy.


Eligibility criteria:
inclusion criteria: * diagnosis of primary breast cancer or gastrointestinal cancer * currently prescribed capecitabine * age 21 years or older * able to understand written and oral english exclusion criteria: * major psychopathology or cognitive impairment likely in the judgment of the research staff to interfere with the participation or completion of the protocol.

Keywords: oral chemotherapy capecitabine questionnaire breast gastric 11-194
maintenance therapy of chidamide in patients with hbv positive diffuse large b-cell lymphoma

Conditions: Diffuse Large B-cell Lymphoma

Summary: a phase ii，single arm，open-label study to assess maintenance therapy of chidamide in patients with hepatitis b virus（hbv）positive diffuse large b-cell lymphoma with complete response after completion of prior chemotherapy

objective to evaluate the efficacy and safety of maintenance therapy with chidamide in patients with hepatitis b virus（hbv）positive diffuse large b-cell lymphoma（dlbcl） with complete response after completion of prior chemotherapy, so as to provide the basis for the application of chidamide in hbv positive dlbcl

Eligibility criteria:
inclusion criteria: * histopathology confirmed dlbcl，with chronic hepatitis b before treatment * after systemic treatment, complete response has been achieved and complete response lasted within 1year before enrollment * the expected chemotherapy was completed and the laboratory indexes returned to normal * the absolute value of neutrophil ≥ 1.5 × 10 9 / l, platelet count≥ 90 × 10 9 / l, hemoglobin level≥ 90 g / l * patients who cannot undergo hematopoietic stem cell transplantation for various reasons * 18-75 years old, both male and female * ecog ps 0-1 * body weight: male 67 ± 20 kg (47-87 kg), female 55 ± 20 kg (35-75 kg) * expected survival time ≥3 months * voluntary written informed consent prior to trail screening exclusion criteria: * pregnant and lactating women and women of childbearing age who are unwilling to take contraceptive measures * patients with prolonged qtc interval (male \> 450ms, female \> 470ms), ventricular tachycardia (vt), atrial fibrillation (af), heart block, myocardial infarction (mi) within 1 year, congestive heart failure (chf), and coronary heart disease with symptoms requiring drug treatment * b-ultrasound showed that the width of the fluid dark area in the pericardial cavity was ≥ 10 mm at the end of diastolic period * patients with previous or planned organ transplantation * patients receiving symptomatic treatment for early myelotoxicity within 7 days before enrollment * hbv nucleic acid quantitation \> 103 iu / ml * patients with active bleeding * patients with thrombosis, embolism, cerebral hemorrhage, cerebral infarction and other this kind of diseases or medical history * patients with active infection or persistent fever within 14 days before enrollment * less than 6 weeks after major organ surgery * abnormal liver function \[total bilirubin \> 1.5 times of the upper limit of normal value; alt / ast \> 2.5 times of upper limit of normal value for patients without liver metastasis ; alt / ast \> 5 times of upper limit of normal value for patients with liver metastasis \], abnormal renal function (serum creatinine \> 1.5 times of upper limit of normal value) * mental disorders/those who cannot obtain informed consent * patients with drug abuse and long-term alcohol abuse that affect evaluation * the investigator determined not suitable to participate in this study
comparation of proseal laryngeal mask airway with flexible laryngeal airway mask

Conditions: Anesthesia Intubation Complication

Summary: objective to investigate the comparative effect of proseal laryngeal mask airway and flexible laryngeal airway mask during otitis media surgery. methods 200 patients of asa i or ii classification, 18-65 years old, bmi\<30 kg/m2 undergoing otitis media surgery are randomly divided into two groups (group p with proseal laryngeal mask airway and group f with flexible laryngeal airway mask, respectively). after induction, selecting a appropriate size of lma to patient,s weight, using the standard index finger-guided technique inserting the lma, and then the patients were ventilated mechanically. the success rate of inserting laryngeal mask, the intubation time, surgery time and wake time were also recorded. tidal volume and leakage pressure in patients with supine and lateral positioning were assessed respectively. the scale of fiberoptic bronchoscopy was also recorded to show airway exposure. related complications such as sore throat, hoarseness, cough, laryngospasm, bloating, nausea and vomiting, soft tissue injury, blood residue after pulling out the lma were analyzed.postoperative voice and laryngopharyngeal symptom are also recorded.


Eligibility criteria:
inclusion criteria: clinical diagnosis of otitis media. exclusion criteria: problems with the upper airway. gastric carcinoma. reflux esophagitis.
evaluation of the sleep hygiene in the lebanese population during the covid-19 confinement period.

Conditions: Sleep Hygiene

Summary: the term "sleep hygiene" refers to a series of healthy sleep habits that can improve the ability to fall asleep. these habits are the most effective long-term treatment for people with chronic insomnia. the "sleep hygiene index" is a 13-item questionnaire that evaluates these habits. we are in the process of validation of this questionnaire in the arabic language. we will evaluate these habits in the lebanese population during the covid-19 confinement period.

the sleep hygiene will be evaluated during the covid-19 confinement period. the "sleep hygiene index" with other questions will be applied to the lebanese population in english and arabic. it will be distributed by the means of whatsapp and facebook.

Eligibility criteria:
inclusion criteria: * lebanese living in lebanon, 18 yo and over, understanding written english or arabic. exclusion criteria: * not having the inclusion criteria.
survey on the pharmacy follow-up of alli purchasers

Conditions: Overweight

Summary: to assess the feasibility and acceptability of genuine pharmacy follow up of people wishing to lose weight.


Eligibility criteria:
inclusion criteria: * individuals who have been recognized as being eligible for treatment, who have agreed to pharmacy follow up, and have given their informed consent to take part in the survey.

Keywords: behavior modification overweight orlistat
a seek, test, and treat intervention to reduce chlamydia trachomatis disparities

Conditions: Chlamydia; Gonorrhea; Hiv; Syphilis

Summary: this study includes testing for four stis (chlamydia, gonorrhea, syphilis, and hiv) at no cost. if positive, individual subjects will also be counseled and offered options for treatment for themselves and their sex partners that may include no cost expedited treatment and the option to be rescreened 3 months after treatment.


Eligibility criteria:
inclusion criteria: * identifies as african american or black * 15-26 years of age * lives or spends most of their time in orleans parish * had vaginal sex at least once exclusion criteria: * unwilling or unable to provide informed consent * unable to speak or understand english * previously enrolled in the study * known to be pregnant * known hiv positive status

Keywords: screening expedited treatment
axillary staging in early breast cancer: snb vs pet/mri

Conditions: Breast Cancer; Sentinel Lymph Node; Early-stage Breast Cancer

Summary: the gold standard of surgical treatment for patients with early breast cancer (bc) is breast conservation and sentinel node biopsy (snb). ongoing randomized trials are evaluating to omit surgery at all when axillary imaging is negative. however, the available diagnostic tools still have several limitations in accuracy. combining the specificity of pet, with the superior sensitivity of mri, hybrid pet/mri might be a non-invasive, one-stage, operator-independent imaging method to accurately define nodal status and, whenever negative, might replace surgery for axillary staging. the project includes patients with \ 2 mm). additionally, general concordance and diagnostic accuracy of pet/mri vs snb, eventual correlation with bc molecular subtypes and mri findings will be evaluated.

snb is the gold standard for axillary staging in early bc patients. although being a minimally invasive, it is time consuming both for surgeon and pathologist, it may add a further scar and is not free from complications: seroma, limitation of shoulder movement, nerve injury, lymphedema. to date, patients undergoing breast conserving surgery (bcs) with 1 to 2 positive nodes can be treated with snb alone (acosog z011 trial nct00003855\[2-4\]) and researchers are evaluating within large randomized trials to even omit surgery at all when axillary imaging is negative (sound (sentinel node biopsy vs observation after axillary ultra-sound), pi and study chair dr.o.gentilini,md, nct02167490 and insema (intergroup-sentinel-mamma) trial nct02466737. while the role of surgery is decreasing, the role of preoperative imaging is increasing. in the future, imaging might even replace surgery in the axillary staging of bc patients, still providing an appropriate level of information to guide medical treatments which are more and more tailored on biology rather than on nodal status. in this context, an unmet need is to achieve the most accurate preoperative imaging assessment of the axilla in order to decide the appropriate treatment for each patient. the hypothesis of this project is that pet/mri might provide a single, one-stage, non-invasive, operator independent imaging modality in patients with small bc allowing to select the proper treatment for patients. pet/mri is a relatively new imaging tool and its field of application is still object of scientific speculation.

Eligibility criteria:
inclusion criteria: * signed informed consent * age \> 18 * non palpable lymph nodes * no suspicious nodes at a-us (axillary- ultrasound) * candidate to mastectomy or breast conserving surgery and bls (sentinel node biopsy) exclusion criteria: * pregnancy * distant metastasis * inflammatory cancer * claustrophobia * allergy to contrast agent * severe renal insufficiency

Keywords: pet/mri sentinel node biopsy early breast cancer
impact of socioeconomic status and oral hygiene practice on periodontal health of egyptian adults

Conditions: Periodontal Health

Summary: evaluation the relationship between the socioeconomic status and periodontal health of egyptian adults.

it is a cross-sectional study for evaluation and assessment of periodontal health, socioeconomic status and oral hygiene measurements among egyptian adults recruiting from the outpatient clinic and the payed treatment clinics at faculty of dentistry, cairo university. the faculty of dentistry, cairo university is an open public facility, a tertiary healthcare and a referral center.

Eligibility criteria:
inclusion criteria: * -patients whose age is 18-70 years old recruiting from the outpatient clinic and the payed clinic * provide informed consent. exclusion criteria: * patients having problem in opening their mouth or undergoing intermaxillary fixation where oral examination will not be possible. * patients diagnosed with psychiatric problems or intoxicated with alcohol or drugs. * pregnant patients. * patients undergoing orthodontic treatment. * patients who had undergone periodontal treatment over the past six months.
invasive aspergillosis after allogeneic hematopoietic stem cell transplantation (hsct)

Conditions: Hematological Diseases; Invasive Aspergillosis

Summary: evaluation of incidence of invasive aspergillosis in patients who have undergone an allogeneic stem cell transplantation, with particular regard to the role of galactomannan assay and of early tc scan in asymptomatic patients.


Eligibility criteria:
inclusion criteria: * age \> 16 years * allogeneic hsct for a haematological disease * written informed consent to the study exclusion criteria: * pediatric patients

Keywords: allogeneic transplantation invasive aspergillosis
community health equity accelerator (chea) pediatric asthma intervention

Conditions: Asthma in Children

Summary: the purpose of this pilot is to initiate an academic-community partnership and launch a multi-level intervention that includes an asthma exposure pathway (an online decision support and resource) and a health promotora program that will provide culturally responsive asthma support alongside legal and medical services to improve access to asthma care and ultimately improve asthma-related outcomes in the new haven region.

in this will be a prospective, non-randomized, observational, multi-level pilot intervention, general pediatricians and specialists in new haven, connecticut will utilize a newly developed clinical pathway that will be publicly available at the yale pediatrics clinical pathways website and accessible within the electronic health record (ehr) via integrated software to submit referrals for participants in a promotora (community health worker) asthma home-visiting intervention. the hispanic federation promotoras, who are partners in this study who have received human subjects research training, will enroll participants in the study. for each participating family, promotora home visits will be scheduled 6-8 weeks apart, with in-person or virtual visits conducted per the family's preference. the promotoras, who have received specialized asthma training, will address concerns raised by families, using the clinical pathway as a resource (the pathway will have resources for asthma-related concerns that are raised). a clinician from the study team will be on call at all times for the promotoras in case urgent questions arise, and weekly case-conferences will be arranged to discuss any additional needs for support. in this study, the primary outcomes will include measures of feasibility of both promotora home visits and pathway utilization. the investigators will evaluate secondary outcomes using an interrupted time series analysis to evaluate asthma-related outcomes. in addition to survey data, asthma exacerbation metrics will be collected from the electronic health record.

Eligibility criteria:
inclusion criteria: children with a diagnosis of asthma with at least one of the following: * oral steroid prescription in past 12m * ed visit for asthma in past 12m * hospital admission for asthma in past 12m * asthma control test (act) score at visit ≤19 * concern for asthmogenic exposure in the home (such as mold, pests, smoking, or pollution) * at least one missed follow-up appointment for asthma * at least one asthma exacerbation in the prior year * interested in asthma education (such as education in how to prevent asthma or how to administer medications) * concern for medication non-adherence exclusion criteria: * living outside of new haven zip code

Keywords: medical legal partnership community health worker health harming legal needs
adult stem cell therapy in liver insufficiency

Conditions: Liver Cirrhosis

Summary: in order to determine the clinical application potential of adult stem cells we propose to investigate the safety and toxicity of infusing adult stem cells in the hepatic artery or portal vein of five patients with chronic liver insufficiency and to identify any clinical benefit if such occurs. objectives: 1. to assess safety and treatment related toxicities 2. to determine clinical benefit or deterioration by monitoring changes in liver function

the liver in an adult healthy body maintains a balance between cell gain and cell loss. though normally proliferatively quiescent, hepatocyte loss such as that caused by partial hepatectomy, uncomplicated by virus infection or inflammation, invokes a rapid regenerative response to restore liver mass. this restoration of moderate cell loss and 'wear and tear' renewal is largely achieved by hepatocyte self-replication. more severe liver injury can activate a potential stem cell compartment located within the intrahepatic biliary tree, giving rise to cords of bipotential, so-called, oval cells within the lobules that can differentiate into hepatocytes and biliary epithelial cells. a third population of stem cells with hepatic potential reside in the bone marrow; these haematopoietic stem cells can contribute to the albeit low renewal rate of hepatocytes, make a more significant contribution to regeneration and even completely restore normal function in a murine model of hereditary tyrosinaemia. a recent abstract has suggested that an astonishingly high number of bone marrow cells (\~25% of liver parenchyma occupied by bone marrow-derived cells) will engraft and differentiate into hepatocytes in a model of cirrhosis in the mouse when injected intravenously. more importantly, this bone marrow infusion resulted in significant improvements in liver function (serum albumin) within the cirrhotic animals. this is a safety and toxicity study in five patients with chronic liver disease. each will receive autologous stem cells 10 to the sixth cells via the hepatic artery or portal vein under image guided scanning. patients will be followed for a total of 60 days.

Eligibility criteria:
inclusion criteria: - male or female aged from 20 years to 65 years evidence of chronic liver failure abnormal serum albumin and/or bilirubin and/or prothrombin time unsuitable for liver transplantation who performance status \<2 women of childbearing potential may be included but must use a reliable and appropriate contraceptive method life expectancy of at least three months ability to give informed consent exclusion criteria: - patients aged below 20 years or above 65 years pregnant or lactating women patients with recent recurrent gastrointestinal bleeding spontaneous bacterial peritonitis evidence of active infection hiv infection patients unable to give informed consent

Keywords: adult stem cells liver disease cd34 positive cells
effect of preoperative incentive spirometer on postoperative pulmonary complications following lung resection

Conditions: Postoperative Respiratory Complication

Summary: the objective of this study is to demonstrate that inspiratory muscle training with daily use of an incentive spirometer for at least 14 days prior to lung surgery will reduce the risk of post-operative pulmonary complications.

postoperative pulmonary complications (ppc) are the most common adverse events following lung resection, with a reported incidence of over 20-30% in some series. the objective of this study is to demonstrate that inspiratory muscle training (imt) with daily use of an incentive spirometer (is) for at least 14 days prior to lung surgery will reduce the risk of ppcs compared to the usual care, consisting of no formal preoperative imt. the hypothesis is that preoperative inspiratory spirometer breathing (isb) is a feasible and cost-effective intervention that can significantly reduce ppcs after lung resection. it is also hypothesized that patient compliance with the intervention will be high because of its simplicity, convenience, low cost and no potential for adverse effects.

Eligibility criteria:
inclusion criteria: * ecog performance status score 2 or less * undergoing elective lung resection (includes wedge resection, lobectomy, bi-lobectomy, pneumonectomy, sleeve resection) via minimally invasive (vats or robotic) approach or thoracotomy * chest wall resection if performed concurrently with lung resection exclusion criteria: * ecog performance status score greater than 2 * significant cognitive impairment preventing informed consent * non-english speaking * wedge biopsy for interstitial lung disease * bullectomy for bullous emphysema * pre-existing tracheostomy * emergent or urgent surgery * preoperative home oxygen use * history of neuromuscular disease * prisoners

Keywords: incentive spirometry inspiratory muscle training pulmonary resection