Kornimate/medical-research-clean huggingface dataset:
clinical, functional and musculoskeletal differences between adult patients with hemophilia and their healthy peers

Conditions: Hemophilia Arthropathy

Summary: background. hemophilia is characterized by the development of a progressive, degenerative, intra-articular lesion (hemophilic arthropathy). this arthropathy presents with chronic pain, limited range of motion, axial changes, and periarticular muscle atrophy. goal. to analyze the clonic, functional and musculoskeletal differences between adult patients with hemophilic arthropathy of the knee and ankle and their healthy peers. study design. cases and controls study patients. 21 patients with hemophilia a and b and 21 subjects without joint damage. variables and measuring instruments: pressure pain threshold (pressure algometer); joint status (hemophilia joint health score scale); and strength (dynamometry) and muscle activation (surface electromyography). expected results. observe the differences between patients with knee and ankle arthropathy and their healthy peers in muscle strength and activation.


Eligibility criteria:
inclusion criteria: * patients diagnosed with hemophilia a and b. * over 18 years * with medical diagnosis of knee arthropathy * with clinical evaluation by hemophilia joint health score * in prophylactic treatment or on demand with fviii / fix concentrates for coagulation. * healthy subjects must meet knee joint health criteria; over 18 years; and no previous knee or ankle injuries in the 6 months prior to evaluation. exclusion criteria: * patients with neurological or cognitive disorders that prevent the understanding of physical tests * not having signed the informed consent document

Keywords: hemophilic arthropathy ankle knee strength muscle activation pressure pain threshold
a new multi-parameter neuromonitoring system to save patients' lives in stroke and brain injury

Conditions: Subarachnoid Hemorrhage; Optical Imaging

Summary: to assess the feasibility of a new neuromonitoring system (nemosystem including nemo probe and nemo patch) and the accuracy of the measurement values (cerebral blood flow (cbf); cerebral blood volume (cbv)) obtained.


Eligibility criteria:
inclusion criteria: 1. adult male or female patient, ≥ 18 and ≤ 75 years 2. patient with severe sah (gcs ≤ 12) or severe tbi (gcs ≤ 8) 3. decreased level of consciousness with the need for icp monitoring for an estimated duration of more than 3 days 4. negative pre-treatment serum pregnancy test for female patients with childbearing potential 5. in patients with severe sah or severe tbi with need for icp monitoring an acute emergency situation exists. the inclusion follows exclusion criteria: 1. known kidney disease, defined as plasma creatinine \> 120 µmol/l 2. known liver disease, defined as got \> 200u/l 3. history of allergic disorders, including allergic reactions against contrast agents containing iodine, against icg and against plasters, as well as patients with thyroid disease causing hyperthyroidism 4. pre-existing disability and/or legal representative 5. participation in another interventional clinical trial within the last 30 days before start of treatment
benefit of a diagnostic mri in case of pathological nipple discharge with normal mammography / ultrasound

Conditions: Breast Cancer

Summary: benefit of mri in pathological nipple discharge.


Eligibility criteria:
inclusion criteria: 1. single pore nipple discharge neither green nor milky. 2. mammography (at least 2 shots, +/- centred on retro-areal) normal. 3. initial ultrasound: normal. 4. age over 18 years 5. female 6. patient affiliated to the social security scheme. 7. patient information and informed consent signed and dated exclusion criteria: physiological milky or green discharge
tdcs on precuneus in mcs: repeated stimulations

Conditions: Patients in Minimally Conscious State After a Severe Brain Injury

Summary: in this study researchers will apply transcranial direct current stimulation (tdcs) for 5 consecutive days in chronic patients in minimally conscious state (mcs).

positive effects of tdcs in patients in mcs was showed in a recent study published in neurology. but the effects went down after 1 or 2 hours. to increase the lasting of the effects, a new study will evaluate the effects of tdcs on the precuneus cortex for 5 consecutive days in chronic patients in mcs. 2 sessions of 5 days of stimulation will be realized, one session will be real (anodal stimulation) and one placebo (sham stimulation). after each stimulation, behavioral improvement will be assessed with the coma recovery scale revised (crs-r). a final assessment will be done 5 days after the end of the sessions to assess the long term effect of the tdcs. researchers expected to see an improvement of the crs-r total score at the end of the anodal session and that this improvement persists for 5 days.

Eligibility criteria:
inclusion criteria: * post comatose patients * patients in minimally conscious state * patients with stable condition * patients free of sedative drugs and na+ or ca++ blockers (e.g., carbamazepine) or nmda receptor antagonist (e.g., dextromethorphan) exclusion criteria: * premorbid neurology antecedent * patients in coma or vegetative state * patients \< 1 months after the acute brain injury * patients with a metallic cerebral implant or a pacemaker (in line with the safety criteria for tdcs in humans)

Keywords: disorders of consciousness minimally conscious state traumatic brain injury stroke transcranial direct current stimulation
effect of high-intensity laser exercise versus moderate-intensity aerobic exercise on diabetic polyneuropathy patients

Conditions: Diabetic Nephropathies

Summary: diabetic poly neuropathy (dpn) is a length-dependent, symmetrical sensorimotor poly neuropathy and is among the most prevalent and challenging consequences of diabetes4. the documented prevalence of dpn varies between 13% and 55%, with 25% to 50% of these individuals experiencing neuropathic pain5. this study was conducted to find out the impact of high-intensity laser versus moderate-intensity aerobic exercises on diabetic poly neuropathy patients.


Eligibility criteria:
inclusion criteria: * neuropathic symptoms in the lower limbs, including numbness, tingling, pain, burning, electric shock, and stabbing exclusion criteria: * sensory polyneuropathy unrelated to diabetes as * systemic diseases, * infections, * inflammatory conditions, * drug effects, * metal exposure, * hereditary factors
neural mechanisms of clinically designed improvisatory music for alzheimer's disease

Conditions: Alzheimer Disease

Summary: clinically designed improvisatory music (cdim) is a form of improvised music based on calm-inducing sound parameters which brought relief to our cohort of neurology patients. as a direct sound-based approach, cdim does not rely on autobiographical memory and may have wider applicability and generalizability. we wish to examine if cdim decreases anxiety in 15 cognitively healthy individuals and 15 alzheimer disease patients with anxiety (ad-a).

the goal of this study is to identify the neural mechanisms of induced calmness through live clinically designed improvisatory music (cdim) in cognitively healthy individuals and persons with alzheimer's dementia suffering from agitation. this study is novel as most music interventions for dementia use familiar music and the underlying neural mechanism of calmness induced by music is not well known. we plan to investigate changes in 3 major large-scale brain networks using functional magnetic resonance imaging (fmri). the major questions we plan to answer are as follows: 1. how does improvisatory music change the connectivity within brain emotion related networks in neurotypical individuals? 2. does improvisatory music induce a state of calmness in individuals with alzheimer's dementia and how? based on objective evidence provided by this study we can justify further usage of music for patients with alzheimer's, in particular, in the form of improvisation.

Eligibility criteria:
inclusion criteria: 1. cognitively healthy individuals cognitively healthy control participants evaluated through the northwestern mesulam center. bai \> 8. exclusion criteria: hearing loss 2. individuals with mild to moderate alzheimer's disease this group will similarly be recruited through the mesulam center. all individuals recruited by the research core at the center are well characterized tests standardized across all nih funded alzheimer centers across the nation. individuals with mild to moderate neurocognitive disorder due to ad will have an mmse greater than \>15 and clinical dementia rating (cdr) between 0.5 and 2.. they will also have a history of neurocognitive-related agitation/anxiety, and a beck anxiety index (bai) greater than 8, suggestive of at least a mild level of anxiety. exclusion criteria: mmse\ 2, hearing loss

Keywords: anxiety alzheimer dementia agitation irritability music intervention music medicine music improvisation
individualized anterior cruciate ligament versus conventional reconstruction

Conditions: Anterior Cruciate Ligament Injuries

Summary: a randomised prospective control trial comparing the efficiency of a more individualized approach in acl reconstruction with the help of neuromuscular computer models with traditional acl reconstruction practices.

until now the acl reconstruction was based on the surgeon's experience. an individualised acl reconstruction is customized based on each patient's special characteristics. preoperative and intraoperative evaluation of the native acl (both anteromedial and posterolateral bundles), knee anatomy and function, level of activity and generalised ligamentous laxity are assessed. femoral and tibial tunnels should be placed in their anatomical location accounting for both the native acl insertion site and bony landmarks. two groups will be created, one with patients undergoing acl reconstruction based on a surgeon's experience and one based on a more individualised approach according to the particular characteristics of each patient separately. in addition, patients in the second group will undergo acl reconstruction with the use of computer assisted system (navigation). preoperatively and postoperatively, the patients will be assessed with the kt2000 system, the koos (knee injury and osteoarthritis outcome), the tegner- lysholm knee scoring system and the ikdc (international knee documentation committee). additionally, all patient will be examined for their knee function with the use of a 3d gait analysis system. the follow-up examination will take place 6 and 12 months after the surgery.

Eligibility criteria:
inclusion criteria: * patients with acl rupture undergoing acl reconstruction surgery with closed epiphyses, younger than 45 years old exclusion criteria: * no previous surgery in the knee (except partial meniscectomy), no major systematic pathology

Keywords: acl anterior cruciate ligament reconstruction individualised anatomical navigation
effects of noninvasive brain stimulation on brain activity and appetite

Conditions: Hyperphagia

Summary: the goal of this project is to identify brain mechanisms by which noninvasive brain stimulation (nibs) could decrease hyperphagia. the investigators will synchronously deliver nibs and measure brain activity in a randomized, crossover, sham-controlled, fully blind study. this work will reveal brain mechanisms to reduce hyperphagia and may contribute to new therapeutic avenues to treat this eating disorder.


Eligibility criteria:
inclusion criteria: * hyperphagic exclusion criteria: * psychiatric disorders * pregnancy
epidemiology of pecan nut allergy

Conditions: Allergic Reaction

Summary: ige-mediated food allergy can manifest with reactions ranging from hives to anaphylactic shock. the diagnosis is based on the confirmation of sensitization to the food allergen by skin tests (prick) and the determination of specific ige directed against the food source and molecular allergens. the gold standard remains the oral provocation test, which is performed in a hospital environment. once the diagnosis is made, an elimination diet is still considered as the cornerstone of treatment for most food allergies. while some allergies, such as cow's milk or egg, tend to resolve spontaneously, others, such as allergy to pecan nuts, show a tendency to be persistent. in addition, pecan allergy is often characterized by potentially serious clinical reactions, compared to other foods, which can even be life threatening. in our clinical practice, the investigators found that patients with allergies to pecan nuts often present with severe hypersensitivity reactions when challenged orally to this food. beyond this information, there are few studies regarding pecans. the investigators decided to retrospectively evaluate the results of oral food challenge and of the allergy work-up in our patients sensitized and allergic to pecan nuts, to better understand the current epidemiology of such food allergy.


Eligibility criteria:
inclusion criteria: * patients assessed for pecan allergy, through oral food challenge, from january 2000 to december 2021, at the university hospital of montpellier * patients with a positive skin prick test and/or positive specific ige to pecan nut exclusion criteria: * patients not affiliated to french social security * patients not capable of understanding french * patients sensitized to pecan nut, who did not perform an oral food challenge to this food allergen

Keywords: sensitization to pecan nut (specific ige and/or skin prick tests) challenge proven pecan allergy allergic comorbidities oral food challenge anaphylaxis
topical bimatoprost effect on androgen dependent hair follicles

Conditions: Male Pattern Hair Loss; Androgenetic Alopecia

Summary: the purpose of this study is to determine the effect of bimatoprost solution on scalp hair growth. bimatoprost 0.03% ophthalmic solution is currently approved by the fda for treatment of glaucoma (lumigan™) and for thickening of thin eyelashes (latisse™). bimatoprost 0.03% is not approved for the treatment of scalp hair loss and its use in this study is considered investigational which means it is still being tested in research studies. thirty-three subjects were consented and screened, 9 entered and 9 completed the study.


Eligibility criteria:
inclusion criteria: 1. hamilton-norwood patterns of baldness iiiv, iv, v, or va. 2. subject's hair color must have adequate contrast against scalp color to allow hair counting on macrophotography. 3. good health with normal blood tests for hematological, renal, and liver function. 4. able to return to duke for study visits. exclusion criteria: 1. ecog \>1. 2. used topical or oral minoxidil in the past 6 months, oral finasteride in the past 12 months or oral dutasteride in the past 24 months. 3. taken any warfarin, heparin, or retinoid for greater than 2 weeks during the past 6 months and any in the past month. 4. taken any chemotherapy in the past 2 years. 5. used any over-the-counter (otc) preparation that purports to help hair growth in the past four months. 6. used prostaglandins of any type in the past or currently. 7. any history of alopecia areata, cicatricial alopecia, radiation to the head, hair transplants, or scalp reductions. 8. any skin abnormalities in the target area that would effect hair growth. 9. any history of glaucoma or elevated intraocular pressure (iop). 10. any cancer other than non-melanoma skin cancer (nmsc) in the past 2 years and all must be in remission.

Keywords: male pattern hair loss androgenetic alopecia bimatoprost
effect of crystalloids with different sid on ph, and urinary electrolytes during general anesthesia

Conditions: SID; Acid-Base Imbalance

Summary: the present study will investigate variations in acid base equilibrium caused by the administration of four different crystalloids with increasing strong ion difference (0.9% saline, ringer's lactate, ringer's acetate, plasmalyte-like solution) in patients during general anesthesia. the same crystalloid will be administered throughout the surgery. in order to assess the effect of hemodilution, every patient will receive two fluid boli with different volumes of the same solution. ph and strong ion variations, togher with the renal response to acid base disturbances, will be analysed.


Eligibility criteria:
inclusion criteria: * adult patients (between 18 and 75 years old); * asa (american society of anesthesiologists) physical status classification system 1 or 2; * patients undergoing spinal surgery under general anesthesia, intubated and mechanically ventilated; * normal preoperative albumin; * surgery with an estimated duration of at least 3 hours. exclusion criteria: * patients who are pregnant; * patients with obesity (bmi \> 35); * patients with a chronic obstructive pulmonary disease (copd); * patients with obstructive sleep apnea (osa) treated with cpap; * patients with chronic heart failure (chf) with a nyha (new york heart association) class ≥2; * patients receiving diuretics in the pre-operative period; * patients with a chronic kidney disease (ckd), defined as a gfr \< 60 ml/min/1.73 m2; * patients with diabetes mellitus treated with insulin; * patients with myopathies; patients undergoing a surgery with likely fluid losses or with unexpected bleeding during surgery.

Keywords: ph crystalloids
resistance training for patients diagnosed with external snapping hip

Conditions: Coxa Saltans External

Summary: the purpose of this study is to investigate whether targeted progressive resistance training is safe and feasible for patients with external snapping hip. dropout rates, adverse events and training adherence are investigated. the secondary purpose is to investigate whether it is possible through targeted progressive resistance training to improve participants' muscle strength, functional status and hip-related quality of life.

snapping hip (coxa saltans) is a disorder where the hip tends to make an audible click-through movement, often but not necessarily associated with pain. a prevalence of 5-10% of the general population has been reported. snapping hip is divided into three forms of snapping hip; intraarticular, internal and external snapping hip. external snapping hip (coxa saltans external) is the most common form, and patients may experience pain when the iliotibial band or anterior part of the gluteus maximus slides over the greater trochanter at femur. patients with external snapping hip are typically between 15 and 40 years, and physically active.

Eligibility criteria:
inclusion criteria: * diagnosed with greater trochanteric pain syndrome at the orthopedic surgery department at aarhus university hospital in the period 2013-2015. in case of too few participants from this sample, we plan to include patients diagnosed during 2018 * minimum 18 years old * able to read and understand danish * have experienced jump/click from the outside of the hip associated with pain within the last 14 days * have a residence of a maximum of 55 km from aarhus c * the participants must not have participated in regular resistance training of the hip muscles for more than 1 day per week in the last 6 months leading up to the start of the intervention * the participants must not have undergone a total hip replacement, a periacetabular osteotomy, a z-plastic surgery or arthroscopy in the hip within 6 months before the start of the intervention or have a planned hip surgery during the intervention period * the participants must not suffer from neurological, rheumatological, metabolic or respiratory diseases that will influence the effect of the intervention * the participants must not have a planned vacation lasting more than 14 days during the intervention period, while not having the opportunity to extend the training period accordingly exclusion criteria: * bmi \>40 * no longer suffering from external snapping hip * pregnancy

Keywords: resistance training feasibility
single ascending dose safety study of oxfendazole

Conditions: Tenia Solium Infection

Summary: this research is being done to learn about the safety in humans of a medicine that is already used in cows and pigs to treat worms. the medicine may be useful for people who have these or other worms. the medicine will be studied first in healthy people, who will be given a very small amount of the medicine once. if the smallest amount of medicine is found to be safe, a slightly higher amount will be given to a new group of volunteers. the highest amount that will be tested is similar to the amount given to animals. if the medicine can be given safely to healthy people in the planned amounts, a later study will be done in people who have worms to see if the medicine kills the worms.

the phase i study proposed is a randomized, double-blind, placebo-controlled evaluation of the safety and pharmacokinetics of escalating single oral doses of oxfendazole (0.3 to 30 mg/kg) in healthy volunteers. the dose will be increased approximately three-fold (one-half log) at each increment, and each cohort will comprise ten volunteers (eight drug, two placebo). subjects will be monitored for three weeks after dosing, including monitoring the pharmacokinetics and metabolism of oxfendazole in blood and urine. each new cohort will be dosed only after the three week safety data for the preceding group have been analyzed. if a clinically significant adverse event is observed, and if this event is possibly drug-related, an additional (and final) cohort of volunteers will repeat the highest tolerated dose of oxfendazole. up to 70 volunteers (56 drug, 14 placebo) will complete the study.

Eligibility criteria:
inclusion criteria: * height and weight within 25% of means for his/her gender and age. * willing to use two acceptable methods of contraception (approved oral, injectable, or implantable drug, iud, diaphragm or condom with spermicidal jelly or foam, or sexual abstinence) for a minimum of one week before, and three weeks after dosing with oxfendazole; or surgically sterile. * able to give written informed consent. * able to provide a home phone number, and the name, address, and phone number of a person willing to assist making contact during the follow-up phase of the study. exclusion criteria: * pregnant. * breast feeding. * chronic drug/alcohol user. * has clinically significant abnormalities in screening examinations * has history of sensitivity to related benzimidazole compounds (e.g. albendazole, mebendazole).

Keywords: taenia solium neurocysticercosis oxfendazole clinical trial, phase 1 safety pharmacokinetics