Kornimate/medical-research-clean huggingface dataset:
breathing room intervention to achieve better lung health in older adults

Conditions: Breathing; Aging

Summary: this proposed study will evaluate whether a novel nonpharmacological intervention, breathing room, can improve lung function in the target population of older adults. therefore, the primary aim of this pilot is to examine the effect of breathing room on inspiratory muscle strength, spirometry confirmed ventilatory function (forced expiratory volume in one second (fev1), forced vital capacity (fvc) and fev1/fvc), functional status, posture, physical activity, and lower respiratory infection rates.

restrictive ventilatory patterns (rvps) contribute to two prevalent problems in older adults: 1) the development of pneumonia and other lower respiratory infections; and 2) declining endurance for physical activity. the breathing room was developed as an exercise activity designed to open the thoracic cage, increase strength of the muscles of respiration with inspiratory muscle trainers, and optimize the breathing technique. this will be a pretest-posttest design in which the outcomes are measured at baseline, and at two weeks and four weeks post start of breathing room intervention. breathing room classes will be held 3 times a week for 4 weeks (2 group classes, 1 individual reinforcement of inspiratory muscle training \[imt\] homework). the imt homework includes 3 days 5 cycles of 5 breaths, each cycle followed by 2-minute rest. the imt will be also utilized during the 2 group classes. the group classes will be conducted with a maximum of 5 participants in each group. data on inspiratory muscle strength, spirometry confirmed ventilatory function (forced expiratory volume in one second (fev1), forced vital capacity (fvc) and fev1/fvc), functional status, posture, and physical activity will be collected. infection rate data for each resident for 4 months following completion of breathing room will be also collected.

Eligibility criteria:
inclusion criteria: * able to understand english * baseline oxygen saturation level is above 85% * spirometry-confirmed restrictive ventilatory pattern (forced vital capacity \< 80% predicted, forced expiratory volume in 1 second/forced vital capacity ≥ 0.70 exclusion criteria: * have lung disease classified as restrictive or obstructive * have unstable angina/myocardial infarction, eye or lung surgery within the previous 8 weeks or aneurysm * have had major orthopedic surgery in the last 12 weeks * have been told they have heart failure, take a diuretic "water pill" and have been told to restrict their salt and fluid intake (symptoms that coincide with stage c of heart failure based on the american college of cardiology and the american heart association classification system * score in the severely impaired range on the short orientation memory concentration test * history of spontaneous pneumothorax
significance of immunohistochemical expression of survivin in renal cell carcinoma

Conditions: Renal Cell Carcinoma

Summary: detection of survivin expression in renal cell carcinoma and correlate this expression to tumor grade and stage.

renal cell carcinoma is the third most prevalent malignant tumor of the genitourinary system. deregulation of apoptosis is involved in carcinogenesis by abnormally prolonged cell survival, facilitating accumulations of multiple mutations and augment resistance to immune-surveillance. survivin is a member of inhibitor of apoptosis protein family (iaps). it play a role in cell cycle regulation by inhibiting apiptosis. survivin is over-expressed in many human neoplasms.

Eligibility criteria:
inclusion criteria: * patients suffer from renal cell carcinomas exclusion criteria: * patients received pre-operative chemotherapy or radiotherapy. patients with insufficient clinical data.

Keywords: renal cell carcinoma survivin immnuohistochemistry
efficacy and safety of luo-fu-shan plaster in patients with rheumatoid arthritis

Conditions: Arthritis, Rheumatoid

Summary: the aim of this study is to assess the efficacy and safety of luo-fu-shan plaster in patients with rheumatoid arthritis.

the investigators are inspired by chinese traditonal herb, an therapy for thousands of years, and take its advantage to make luo-fu-shan plaster in order to get an effective and safe treatment for active ra patients. the study is a multicenter, randomized, double-blind, placebo-controlled trial.

Eligibility criteria:
inclusion criteria: * male or female subjects aged 18 to 75 years (time of get informed consent) * documented diagnosis of rheumatoid arthritis, as defined by the american rheumatism association 1987 revised criteria. * documented diagnosis of damp-heat syndrome according to traditional chinese medicine. * if patients are receiving disease-modifying anti-rheumatic drugs (dmards), then the doses should have been kept stable for at least 12 weeks. * if patients are receiving non-steroidal anti-inflammatory drugs (nsaids) or orally chinese herbal medicine, then the doses should have been kept stable for at least 4 weeks. exclusion criteria: * skin allergies or broken skin; * taking glucocorticoids,more than 10 mg daily. * female patients who are pregnant, breast-feeding or planed to be pregnant;

Keywords: rheumatoid arthritis external therapy herb medicine
evaluation of functional insulin therapy in type 1 diabetic patients

Conditions: Type 1 Diabetes

Summary: functional insulin therapy (fit) is an heath care method proposed to type 1 diabetic patients which focuses on patient autonomy, carbs counting and insulin dose adaptation. the hypothesis is that fit should lead to better glycemic control (hba1c), less hypoglycemia and better quality of life. 60 patient will be enrolled and followed during one year.

functional insulin therapy (fit) is an heath care method proposed to type 1 diabetic patients which focuses on patient autonomy, carbs counting and insulin dose adaptation. in this study we plan to enroll 60 patients who will be educated tofit and followed during one year. patient will follow normal path of eductation which is composed of a 3 days inpatient admission, a medical visit one month after the education, and a 4hours reminder session six months after the education. we will compare hba1c, hypoglycemia, weight, before the education, and after. patient will also wear a continuous glucose sensor during one week before, at month 6 and month 12 to allow comparison of glucose variablity.

Eligibility criteria:
inclusion criteria: 1. age between 18 and 70 2. type 1 diabetes for more than 1 year 3. treatment by basal/bolus insulin therapy and insulin pump for more than 6 months 4. hba1c between 7.5 and 12% 5. volunteer to be educated to functional insulin therapy 6. patient must be willing to undergo all study procedures 7. patient must be affiliated or beneficiary of a social medical insurance 8. patient has signed informed consent form prior to study entry exclusion criteria: 1. type 2 diabetes 2. difficulties with mathematics calculation (simple algebra) 3. patient is pregnant, or breast feeding during the period of the study 4. manifest psychological disorders 5. patient with eating behaviour desorder 6. alcohol or drug addiction, as identified by investigator during screening visit 7. persons deprived of freedom, adults protected by law or vulnerable persons

Keywords: functional insulin thearpy carbs counting type 1 diabetes mellitus insulin pump treatment by external insulin pump
virtual reality device for rehabilitation of stroke patients

Conditions: Stroke

Summary: this study will evaluate the potential efficacy and safety of using virtual reality gaming in conjunction to standard therapy regimen care as an approach to promote upper-limb motor recovery, cognitive function and quality of life after stroke. the investigators believe that allowing users to interact with a computer-simulated reality environment will result in a pleasant experience, which will likely result in motivation and therapy engagement.


Eligibility criteria:
inclusion criteria: * patient admitted to the uab hospital, older than 18 years old, with a diagnosis of stroke * patient with unilateral upper extremity weakness * patients that after evaluation by physical and occupational professionals were admitted to rehabilitation facility "spain rehabilitation center". exclusion criteria: * patients with severe cognitive impairment * patient with orthopedic impairment (i.e. marked arthritis) * patient with visual disorders limiting therapy session * those for whom voluntary arm movement would cause sufficient discomfort (\>4/10) that could prevent trial completion will be excluded from participation.
the effect of different types of mouthwash on extraction sockets' healing

Conditions: Extraction Socket Healing; Quality of Life; Postoperative Complications

Summary: the goal of this clinical trial is to assess the effect of four different types of mouthwash on socket healing after surgical extractions in male or female patients aged 18 years and older who have a unilateral impacted mandibular third molar indicated for extraction. the main questions it aims to answer are: the effect of bone bioactive liquid (bbl) mouthwash, hyaluronic acid (ha) mouthwash, the chlorhexidine digluconate (chx) mouthwash and warm saline mouth rinse (wsmr) on socket healing after surgical extractions. the effect of bbl mouthwash, ha mouthwash, the chx mouthwash and wsmr on patient related factors and their quality of life. recruited participants will be randomized into four intervention groups: 1. first group will receive bbl mouthwash. 2. the second group will receive chx mouthwash. 3. the third group will be prescribed ha mouthwash. 4. the fourth group will receive warm saline mouth rinse.


Eligibility criteria:
inclusion criteria: * male or female patients aged 18 years and older who have a unilateral impacted mandibular third molar that is indicated for extraction with bone removal and the presence of an adjacent second molar. exclusion criteria: * soft tissue impaction that will not need any bone removal. * presence of any acute oral infection including active pericoronitis. * patients who have undergone radiotherapy in the head and neck region, chemotherapy or systemic long-term corticosteroid treatment. * patients receiving medications known to induce gingival hyperplasia; anticonvulsant (phenytoin), immunosuppressant (cyclosporine a), and various calcium channel blockers (nifedipine, verapamil, diltiazem). * patients who have taken systemic antibiotics less than 3 months prior to baseline. * presence of uncontrolled diabetes, severe nutritional deficiencies and endocrine disturbances. * presence of immune deficiency or any immune disease. * intravenous bisphosphonates or oral bisphosphonate intake for more than 3 years. * smokers and alcoholics. * pregnant or lactating females. * hypersensitivity to one of the ingredients listed in any of the mouthwashes, especially chlorhexidine as reactions to this has been reported in the literature.

Keywords: clinical trial mouthwash socket healing postoperative complications quality of life
multimodality neuromonitoring in xlif

Conditions: Degeneration of Lumbar Intervertebral Disc

Summary: this is a prospective, non-randomized multi-center study to evaluate intraoperative neuromonitoring results in subjects who undergo extreme lateral interbody fusion (xlif) surgery at any number of levels inclusive of l4-5.

subjects will present with degenerative conditions in the lumbar spine that are amenable to surgical treatment and will be screened prior to study enrollment. subjects will undergo neuromonitoring during the xlif operation, as per standard care. they will then be re-evaluated immediately after surgery and at the first standard postoperative follow-up visit (6 weeks) to assess for presence of new neural deficit. if a new neural deficit is identified, the patient will be followed per the investigator's standard follow-up schedule until symptoms have resolved (or are deemed permanent). a total of 300 subjects will be enrolled in this study from multiple centers. the subjects will have degenerative conditions of the lumbar spine with planned treatment including xlif surgery. the following eligibility criteria are designed to identify existing clinic patients for whom study under this protocol is considered appropriate. all subjects must meet the inclusion/exclusion criteria below in order to be considered for enrollment.

Eligibility criteria:
inclusion criteria: * persistent back and/or leg pain unresponsive to conservative treatment for at least six (6) months, unless surgical treatment is clinically indicated earlier * indicated for extreme lateral interbody fusion at any number of levels inclusive of l4-5 * at least 18 years of age at the date of written informed consent * able to undergo surgery based on physical exam, medical history and surgeon judgment * willing and able to return for post-treatment exams according to the follow-up called for in the protocol * signed and dated informed consent form exclusion criteria: * patient has a mental or physical condition that would limit the ability to comply with study requirements * patient is a prisoner * patient is involved in active litigation relating to the spine (worker's compensation claim is allowed if it is not contested) * patient has an underlying neurological disease or neurological deficit that is not associated with the condition for which he/she is seeking surgical intervention (e.g., diabetic peripheral neuropathy) * patient is participating in another clinical study that would confound study data

Keywords: degenerative lumbar conditions
feasibility of a novel resistance exercise in individuals with osteoporosis

Conditions: Osteopenia; Osteoporosis; Postmenopausal Osteoporosis; Sarcopenia

Summary: the aim of the 2 month randomized controlled trial is to investigate the feasibility of a novel progressive muscle resistance exercise in individuals with low bone mass.

in 2008, medical cost of osteoporosis and osteoporosis-related fractures was estimated to be $22 billion. this is further expected to rise because of an increase of 20% in population with osteoporosis, amounting to 12 million adults over the age of 50 years, by 2020, out of which 80% will be postmenopausal women. unfortunately, benefits due to pharmacological interventions have plateaued. consequently, there is a critical need to identify complementary therapies to enhance the treatment of low bone mass in older adults. the aim of this study is to examine the feasibility of novel progressive muscle resistance exercise in postmenopausal women with low bone mass. muscle will be assessed via imaging techniques and isokinetic dynamometer. physical activity will be assessed via activity monitors. blood will be collected to assess bone and muscle biomarkers. balance will be assessed via clinical and biomechanical tests. testing will be performed at 4 time points: baseline, 1 month, 3 month, and 6 months except imaging which will be done at the baseline and 6 months. the findings from this study will help us to understand the feasibility of resistive muscle exercise program in postmenopausal women with low bone mass.

Eligibility criteria:
inclusion criteria: * independent ambulatory * diagnosed with low bone mass exclusion criteria: * uncontrolled hypertension * secondary osteoporosis * fragility fracture, * clinical or laboratory evidence of hepatic * renal disease, * uncontrolled disorders of the parathyroid * thyroid glands, * a history of cancer in the past 5 years, * any structured resistance training within the previous year, and * past therapy with any drug for osteoporosis, * any current therapy for osteoporosis except zoledronic acid, * inability to walk independently or * any other medical conditions which could restrict the potential participants from full participation as decided by their physician.

Keywords: aging bone muscle exercise
a phase i study of famitinib malate in patients with solid tumor

Conditions: Advanced Solid Tumor

Summary: famitinib is a novel oral multitargeted tyrosine kinase inhibitor with antitumor and antiangiogenic activities. this study is designed to evaluate the safety and tolerability of famitinib in patients with solid tumor

1. to evaluate the safety and tolerability of famitinib, and the maximum tolerated dose (mtd) and dose-limiting toxicity (dlt). 2. to determine the pharmacokinetic profile of famitinib and its metabolites . 3. to assess preliminary antitumor activity . 4. to determine preliminary dose and regimen for phase ii study .

Eligibility criteria:
inclusion criteria: * histological confirmed advanced or metastatic solid tumor，at least one measurable lesion, larger than 10 mm in diameter by spiral ct scan(scanning layer ≤ 5 mm ) * no standard therapy protocol available according to patients'condition * both sex, age 18 to 65 * ecog 0-1 * life expectancy more than 3 months * alt,ast,tb≤1.5(unl),normal serum creatinine level, normal electrolyte or can be corrected by medication * subjects receiving damage caused by other therapeutic has been restored, the interval more than six weeks since the last receiving nitroso or mitomycin; more than 4 weeks since last receiving radiotherapy, other cytotoxic drugs or surgery * understand and agree to sign informed consent form. exclusion criteria: * peripheral neuropathy ≥ grade 2(according to nci-ctc 3.0) * preexisting uncontrolled hypertension defined as more than 140/90 mmhg by using single agent therapy, \>grade 1 (nci-ctcae 3.0 ) myocardial ischemia, arrhythmia,cardiac function insufficiency * pt, aptt, tt, fbg abnormal(pt\>16s,aptt\>43s,tt\>21s,fbg\<2g/l), or have hemorrhagic tendency or receiving the therapy of thrombolysis or anticoagulation * active peptic ulcer * previously medication include sunitinib * more than 4 weeks since the last clinical trial * pregnant or lactating women * women of childbearing age do not take effective contraceptive measures * allergies, or known allergy history to components of the drug

Keywords: famitinib advanced solid tumor phase i
research on mechanism of massage therapy on energy metabolism disorder of simple obesity

Conditions: Simple Obesity

Summary: this project is to penetrate and consummate the research mechanism of massage therapy on simple obesity. latest researches indicate that the energy regulation network system of hypothalamus and metabolic disorders on adipocyte may be the pathological bases which result in obesity. the research group have firstly conducted effect studies of massage therapy on model of simple obesity rats and observed some neurobiological mechanism (whole effect mechanism), meanwhile, the team have discussed influences on the development of preadipocyte and function of endocrine with dynamic mechanical stimulation in vitro (local effect mechanism). this research aims at centering on the hypothesis that massage therapy can act on energy regulation network system of hypothalamus specifically, thus regulating the energy metabolic disorders. then applying functional magnetic resonance imaging (fmri) to explore whether patients with simple obesity exist abnormality on energy regulation network system of hypothalamus, ascertain mechanisms how massage therapy treat energy metabolism disorders of simple obesity, deepen mechanism study on how massage therapy prevent and treat obesity and enrich the clinical application's scientific connotation that massage therapy treat simple obesity.

this project will divide in two groups,healthy volunteers and obesity group.healthy volunteers do not accept any treatment while obesity group need accept massage therapy three times a week,18 times in total.and two groups will be checked by functional magnetic resonance imaging (fmri), healthy volunteers for once and obesity group for twice(before treatment, obesity group's image of fmri will compare with healthy volunteers' and the image which is taken after treatment)

Eligibility criteria:
inclusion criteria: 1.above 20% of the normal weight;bmi≥25.0；f%≥30%; 2.18-60 years old； 3.patients agreeing and signing the informed consent for the study． exclusion criteria: 1. the individuals do not adhere to the treatment or are with other treatments. 2. secondary obesity, eg:pituitary diseases, hypothalamic disorder, hypothyroidism, pancreatic diseases，hyperadrenocorticism, postmenopausal obesity etc. 3. having therapy for obesity in the last two weeks. 4. the individuals with server cardiovascular and cerebrovascular diseases and cancer. 5. critical patients or patients combined with liver and kidney damage. 6. individuals with psychosis. 7. female individuals with pregnancy, lactation and planning a pregnancy in the two months.

Keywords: massage therapy simple obesity energy metabolism mechanism
comparison of the guide-wire g-240 to a combination of a flexible/hydrophil and a nitinol guide wire

Conditions: Other Specified Diseases of Biliary Tract

Summary: in ercp practice, most often a combined use of guidewires is necessary to attain a therapeutic aim. e.g. a hyperflexible hydrophilic guidewire is changed after cannulating a stricture to a nitinol wire for improved stability with the use of therapeutic devices. a new guide-wire (g240) combines these characteristics with a stable shaft and a hydrophilic tip. the investigators test the hypothesis that the use of this new guidewire would decrease number of guidewires used within one ercp session.

this is a randomized, monocentric study.

Eligibility criteria:
inclusion criteria: * obstruction of the biliary tract (cross sectional imaging or ultrasonography/lab data) exclusion criteria: * operatively alternated anatomy of the patient. * intervention of the pancreatic duct.