Kornimate/medical-research-clean huggingface dataset:
effect of the combined programme on perioperative anaemia（cppa）

Conditions: Patient Blood Management; Cardiac Surgery; Iron Deficiency Anemia

Summary: we used the preoperative intervention of iron sucrose in combination with human erythropoietin and vitamin c as an innovative combination therapy. this combined treatment strategy aims to improve perioperative anaemia in patients by promoting erythropoiesis and improving iron metabolism. compared with previous perioperative intravenous iron supplementation, this innovative combination therapy strategy takes into account multiple aspects of iron metabolism as well as the biological mechanisms of erythropoiesis, providing a more comprehensive intervention. management of perioperative anaemia in previous studies has largely relied on single intravenous iron supplementation therapy, and although this approach has been effective in raising iron levels, its effectiveness may be limited in patients who have impaired iron utilisation or in situations where concurrent stimulation of erythropoiesis is required. the use of iron sucrose in combination with human erythropoietin and vitamin c, on the other hand, is based on an integrative therapeutic concept aimed at providing a more comprehensive response to perioperative anaemia by simultaneously promoting effective iron utilisation and erythropoiesis.


Eligibility criteria:
inclusion criteria: * age 18 years and above * ferritin \<300µg/l, transferrin saturation \<25%, male 90\<hb\<130g/l or female 90\<hb\<120g/l * elective major cardiac surgery (valve replacement, cabg coronary artery bypass surgery or a combination of both) * asa: grade 1-3 * signed informed consent exclusion criteria: 1. allergy or contraindication to iron sucrose or recombinant human erythropoietin or ascorbic acid 2. patients with a preoperative temperature \>37.5 °c or on non-prophylactic antibiotics 3. pregnancy or breastfeeding stage 4. weight ≤ 50 kg 5. presence of chronic renal insufficiency, urinary stones, oxalate deposits, gout 6. chronic liver disease and/or screening alanine transferase/aspartate transferase above normal 3 times or more above the upper limit of the normal range 7. family history of haemochromatosis, thalassaemia or transferrin saturation \> 50% 8. known history of iron overload 9. other known causes of anaemia (folic acid or vitamin b12 deficiency or haemoglobinopathies, etc.) 10. emergency surgery 11. use of iron, blood transfusion or related anaemia treatment within 12 weeks prior to surgery withdrawal criteria: 1. massive blood transfusion (≥ 10 red blood cells (rbc)/24h) 2. preoperative interventions not performed according to standard 3. cancellation of surgery
acquisition of responses to a methamphetamine-associated cue in healthy humans

Conditions: Substance Abuse

Summary: the aim of the study is to extend our investigations of drug-associated conditioning with healthy volunteers. the investigators have recently completed a pilot study demonstrating that subjects show an increase in self-reported preference for a visual stimulus paired with stimulant drug administration. furthermore, our pilot data suggest that methamphetamine acts synergistically with rewards in the environment, such that this conditioning effect is facilitated by experiencing the drug in the presence of rewarding, or positive events, such as earning money. the investigators now aim to extend these findings by assessing not only self-reported preference, but also attentional and psychophysiological (electromyogram; emg) responses to the drug-associated stimuli.

the study will consist of an orientation session following by 6 experimental study sessions. the first experimental session will consist of a "pre-test", where baseline data regarding attentional, psychophysiological, and self-reported responses tovarious stimuli will be collected. the following 4 sessions will consist of a drug (sedative or stimulant) or placebo. during these sessions, subjects will play simple computer games, as well as complete questionnaires regarding mood and potential subjective drug effects. the subjects will then complete a "test" session, where attentional, psychophysiological, and self-reported responses to the stimuli will be assessed, as in the first experimental session.

Eligibility criteria:
inclusion criteria: * bmi of 19-26kg/m, high school education, * fluency in english, * resting blood pressure less than140/90mmhg and consumption of less than 4 standard alcohol or caffeinated drinks per day. exclusion criteria: * current substance abuse or lifetime substance dependence, * regular medication, * history of cardiovascular illness, * current major axis i dsm-iv disorder (apa, 2004), * mood disorder or psychotic symptoms within the past year. * shift workers and pregnant or nursing mothers will also be excluded.
defining the utility of pet/ct in the follow-up of patients with solid tumors

Conditions: Cancer Recurrence; Solid Tumors

Summary: this is a comparison, at this va hospital,of routine multi-visit and multi-testing for solid tumor recurrence in four tumor groups to a limited scheduled 5 visit history/physical with pet/ct only, over a five year period. the purpose is to show through utilization of the single most sensitive and specific test currently available-pet/ct-that survival for patients in follow-up can be improved.(plus lowering medical costs and increasing patient confidence and compliance with follow-up appointments).

routine visits would include colon:14 visits with cea and 6 cts over a 5 year period plus pet/ct at last visit rectal: 14 visits with cea and 6 cts and 4 procto exams over 5 year period plus pet/ct at last visit head/neck: 14 visits with 4 cts and pet/ct at last visit lung:12 visits plus 4 cts and pet/ct at last visit limited follow-up all groups: a history and physical plus pet/ct at 3 month, 9 month, 18 month, 36 month and 60 month only

Eligibility criteria:
inclusion criteria: * completed primary therapy such that no disease is evident at the time of enrollment in the study exclusion criteria: * patients unable to consent * without diagnosis of colorectal cancer * non-small cell lung cancer or squamous cell cancer of the head and neck * unwilling or unable to participate in the assigned follow-up program * having a serum glucose at time of pet/ct greater than 180mg/dl * stage iv disease or with evidence of disease recurrence post treatment * who are not a candidate for further treatment should a recurrence of disease be identified

Keywords: cancer colorectal head/neck lung pet/ct
rhtpo in critical patients with thrombocytopenia

Conditions: Sepsis; Thrombocytopenia

Summary: the primary objectives of this study are to assess the impact of rhtpo on mortality among severe sepsis patients with thrombocytopenia, as well as changes of platelet counts and platelet transfusion rates.

thrombocytopenia is prevalent among critical patients who is admitted to intensive care unit. researches have shown that thrombocytopenia is associated with mortality among those patients. currently, no standard therapy exist for critical patients with thrombocytopenia. in 2012 ssc guideline, platelet transfusion is induced for thrombocytopenia in critical patients for reducing the risk of bleeding. however, indication for platelet transfusion is relatively strict. no early intervention could be done according to this guideline. previous studies have shown that recombinant human thrombopoietin can reduce severe sepsis with low platelet 28-day mortality in patients with hyperlipidemia, effectively improve peripheral platelet number, reducing the probability of platelet transfusion.the primary objectives of this study are to assess the impact of rhtpo on mortality among severe sepsis patients with thrombocytopenia, as well as changes of platelet counts and platelet transfusion rates.

Eligibility criteria:
inclusion criteria: * patients would be include if diagnosed as sepsis according to accp/ccm criteria platelet counts is less than 50×109/l for 2 continues days patient or legally authorized representative able to provide informed consent exclusion criteria: * subject has had a splenectomy for any reason subject has an active malignancy who is now under chemotherapy subject has a known history of bone marrow stem cell disorder subject is receiving other investigational agents or procedures subject is currently enrolled in, or has completed within the last 30 days, another investigational device or drug study subject is pregnant or breast feeding subject has any kind of disorder that compromises the ability of the subject to give written informed consent and does not have a legally acceptable representative subject has any kind of disorder that compromises the ability of the subject to comply with study procedures subject is less than 18 years or more than 85 years of age history of bone marrow, lung, liver, pancreas, or small-bowel transplantation acute pancreatitis with no established source of infection
music for health project

Conditions: Human Immunodeficiency Virus

Summary: the overall goal of this project is to use technology to improve adherence to antiretroviral therapy (art)and increase access to art adherence care for those hiv+ persons living in rural areas. the live network audio music program mobile application (app) is innovative, practical, portable, and could be rapidly scaled up to address the adherence self-management needs of rural groups nationwide. if successful, the impact on hiv care will be immense and could transform the delivery of hiv self-management and adherence education by overcoming barriers of geographic isolation, transportation, stigma and confidentiality in this vulnerable group.

the project has two primary aims and one exploratory aim. 1.0 revise and adapt the live network (ln) program and manual for rural persons living with hiv/aids (plwha) and develop into a mobile application. 2.0 conduct a randomized controlled trial to test the efficacy of the program. when compared with an educational music control condition at 3, 6, and 9 months post-baseline, those randomized to the ln will have: h1: significantly higher mean antiretroviral therapy (art) adherence rates (measured by pill counts, self report). h2: significantly higher mean levels of art drug levels in hair sample analyses. h3: significantly better clinical indicators: higher mean cd4 lymphocyte counts and percents, a larger proportion achieving virologic suppression (proportion with hiv rna pcr \<50 copies/ml), and smaller proportion with evidence of drug resistance, all as measured by medical record review. 3.0 explore: a) the effects of ln on symptoms and symptom management; b) the roles of self-efficacy, outcome expectancies, and personal goal setting as mediators, and depression and health literacy as moderators of adherence.

Eligibility criteria:
inclusion criteria: * hiv+ individuals initiating art for the first time (except women who may have had art during pregnancy); or hiv+ individuals changing art regimen within the past 3 months due to side effects or virologic resistance; or hiv+ individuals with a detectable viral load ≥ 40copies/ml; or hiv+ individuals on art medication * english speaking * willing to complete 4 assessments * willing to complete monthly, unannounced pill counts * willing to allow collection of hair samples * willing to be randomly assigned to either condition * willing to participate in study activities that include using smart phone and mobile app exclusion criteria: * have a history of bilateral hearing loss (health care provider diagnosed or self-identified) * homeless * have a cognitive impairment (inability to comprehend the informed consent) * display psychotic symptoms, as determined by the brief symptom inventory (bsi)

Keywords: hiv/aids adherence self-management antiretroviral therapy
french national observatory of percutaneous mitral commissurotomy

Conditions: Mitral Stenosis

Summary: the aim of this study is to validate prospectively the predictive score of late results about a diverse population recruited in france and to evaluate the contribution in predicting the outcome of the pmc scanner to study the mitral calcium score and the location of the calcifications.

this is a multicenter prospective observational study conducted in french medico-surgical sites. the percutaneous mitral commissurotomy (pmc) is the standard treatment for mitral stenosis (ms) in patients with rheumatic favorable characteristics. in western countries the ms reaches older patients with less favorable characteristics, including the presence of mitral calcifications. calcifications are a factor of poor outcome of the pmc. the scanner appears as a useful examination for their study but is not carried out systematically. the prediction of late results of the pmc is particularly important in patients with non-ideal characteristics which form a particularly heterogeneous population. a score of late results of the pmc on the wider western series was recently released but has not to date received external validation. in this score, prediction results was multifactorial, with a consideration of paramount clinical factors, but also a prognostic significance of mitral calcifications. the validation of predictive score of late results of the pmc, with the analysis of calcifications, would better select patients who may best benefit from pmc and those for which the surgical management is preferred. the aim of this study is to validate an external sample predictive score of the event-free survival in patients who have had a good immediate result of the pmc. this study, purely observational, does not create any special procedure outside the patient's usual care.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * this will include all consecutive patients with rheumatic ms referred for pmc * patients who agreed to participate in the study, with signed consent exclusion criteria: * contraindication to the pmc * contraindication to non injected scanner for centers performing a scanner * patient refusal to participate in the study

Keywords: percutaneous mitral commissurotomy mitral stenosis
68ga-psma-11 efficacy in detecting bcr prostate cancer in chinese patients

Conditions: Biochemical Recurrence of Malignant Neoplasm of Prostate; Prostate Cancer; BCR Prostate Carcinoma

Summary: this is a prospective, open-label, single-arm, multicenter bridging study in chinese patients with prostate cancer. this multicenter study is planned to be conducted in patients with biochemical recurrence (bcr) of elevated psa after radical prostatectomy or radical radiotherapy. this study investigates how well 68ga-psma-11 pet/ct works in detecting bcr prostate cancer in chinese patient. 68ga-psma-11, developed by telix, is a new molecular entity tracer with the trade name illuccix®, which is approved by fda for the examination of: 1) patients with suspected metastatic pc who are scheduled for initial treatment; 2) patients with biochemical recurrence of elevated psa levels after initial radical radiotherapy.


Eligibility criteria:
inclusion criteria: 1. are able to understand and provide written informed consent document. 2. are chinese males aged ≥ 18 years. 3. have histopathologically confirmed prostate adenocarcinoma and have undergone radical prostatectomy and/or radical radiotherapy and experienced biochemical recurrence (psa should be measured within 30 days of screening). 1. post radical prostatectomy (rp) psa ≥0.2 ng/ml measured 6 weeks after rp 2. post radiation therapy - astro-phoenix consensus definition nadir + ≥ 2 ng/ml rise in psa; 4. have a karnofsky performance status ≥ 60 (or ecog/who equivalent). 5. agree to practice a highly effective method of contraception for at least 28 days after 68ga-psma-11 administration. 6. are willing and able to comply with scheduled exclusion criteria: 1. have a prior history of any other malignancy within the last year, other than skin basal cell or cutaneous superficial squamous cell carcinoma that has not metastasized and superficial bladder cancer. 2. have prior use of radionuclides with an interval of less than 10 physical half-lives before the administration of 68ga-psma-11. 3. are participating or plan to participate in any drug or device clinical study during the study period. 4. have a known hypersensitivity to the active ingredient or its components of 68ga-psma-11. 5. cannot lie flat or remain still while a pet scan is being performed or cannot tolerate a pet scan. 6. have prior history of salivary gland disease or paget's disease. 7. have a history of fracture and anemia within the last year. 8. have abnormalities in physical examination, ecg, and protocol-specified clinical laboratory tests during the screening period that, in the judgment of the investigator, could affect safety or compliance. 9. is deemed not suitable for participating in this trial in the opinion of the investigator.
the effect of an acute bout of exercise on pain sensitivity and clinical pain in adults with chronic low back pain

Conditions: Chronic Low-back Pain

Summary: the goal of this interventional study is to investigate the efficacy of an acute bout of exercises on pain sensitivity (primary aim) and clinical pain intensity (secondary aim) among adults with chronic low back pain. the following question will be answered in this research q1: is acute bout of exercise effective in reducing pain among adults with chronic low back pain? participants who agree to participate and sign the informed consent will be randomized to one of three groups: group 1: isometric exercise with neutral language and no verbal suggestion consisting of 1 rep of wall squat, 3 min or to volitional fatigue at 100° knee angle;(n=30). group 2: isometric exercise with neutral language and no verbal suggestion consisting of 3 reps of wall squat, 3 min or to volitional fatigue at 100°degree knee angle, 30-sec rest between rep, ;(n=30). group 3 (control group): true control (do nothing);(n=30).


Eligibility criteria:
inclusion criteria: 1. aged 18 years or older; and 2. diagnosed with chronic non-specific lbp (lasting for more than 12 weeks). 3. able to perform physical therapy exercises. exclusion criteria: 1. pregnancy. 2. patients who have neurological compromise (e.g., cauda equine syndrome or spinal nerve compromise). 3. patients who have spinal pathologies (e.g., fracture, ankylosing spondylitis) 4. uncontrolled diabetic. 5. who has any history of heart disease (e.g., myocardial infarction, embolism) 6. orthopaedic impairment (e.g., balance problems)
sensorimotor dysfunction of individuals with neck pain

Conditions: Posterior Neck Pain

Summary: systematically assessing the proprioception-coordination capacity of the spine in patients with different severity of neck disability could reveal how the dysfunction of the sensory-motor system was progressed. from the result of the research, a prospective study would be designed to test the hypotheses that described the mechanism of neck pain based on the results to the present study.

the purposes of this research were to investigate the effect of age and chronic neck pain on cervical proprioception, the change of ultrasonographic (usd) patterns in deep neck muscle and superficial neck muscles. the hypotheses of this research included: 1) the alteration of neck proprioception is determined predominantly by the changed activation deep neck muscles and superficial neck muscles. 2) age factor contributes to the alteration of cervicocephalic sensibility, usd pattern of deep and superficial muscles. 3) chronic pain contributes to the alteration of cervicocephalic sensibility, usd pattern of deep and superficial muscles. neck proprioception is measured by an ultrasound-based coordinate measuring system (cms 70p, zebris, germany) by asking the subjects to performed head repositioning to the neutral head position or to a target position in three cardinal plane. these repositioning error expressed in root mean square errors could represent the craniocervical kinesthetic sensibility. the change of muscle thickness (mm) of the superficial (trapezium, splenius) and deep (semispinalis cervicis and multifidus) dorsal neck muscle is measured by a real-time ultrasonographic scanner (hdi 5000, atl ultrasound, usa). image is obtained for each cervical level, and the thickness of the muscle is identified manually using a custom-written c++ computer graphic program. the measurements of pain intensity and pain frequency are modified from the symptoms questionnaire to indicate the intensity, location, frequency and duration of pain and disability of the subjects. the age and pain effects for each independent variables measured in patients with chronic neck pain (pain: intensity, location, frequency, and duration, ndi), will be tested with the general linear model (glm; age and pain factors). the confounding factors such as gender, range of motion, body height and weight are controlled in the regression model.

Eligibility criteria:
inclusion criteria: * posterior neck pain with duration over 3 months exclusion criteria: * surgery on cervical spine * achilosing spondylitis * diabetes mellitus * traumatic injury directly over head and neck area * progressing neurological disease
pre-treatment factors for the development of chronic pain in low back pain patients

Conditions: Low Back Pain

Summary: the purpose of the project is to associate pre-treatment pain sensitivity level, levels of pain catastrophizing and levels of the subgroups for targeted treatment (start) back screening tool in patients with acute low back pain and patients' progression after 12 weeks of treatment by general practitioners.


Eligibility criteria:
inclusion criteria: * patients with low back pain, who have a mobile phone. exclusion criteria: * pregnancy * drug addiction defined as the use of cannabis, opioids or other drugs * alcohol addiction * lack of ability to cooperate * surgery to the spine
comparison of methods for recording post operative pain

Conditions: Pain, Postoperative

Summary: the purpose of the current study is to identify the optimal method of collection of pain intensity data. the study will compare three collection methods: a hand-written pain journal, a smartphone app, and a novel electronic pain recorder device. patients will be randomly assigned to one of three methods and instructed to record their pain level as often as they like. the number of pain intensity recordings per day will then be compared across groups.

pain is a universal experience and at the forefront of all things medicine; however, the way medical professionals deal with it lacks coherence. clinicians often ask their patients how their pain is, but seldom document it with enough information to be useful. the purpose of this study is to determine how we can collect the most self-reported pain intensity data. the investigators will collect this data with time and date-stamped visual analogue scale-a pain rating scale from 0-10-scores for each patient in the study, randomized to one of three groups (pen \& paper, app, and pain recorder device). as pain is a universal experience and a hallmark sign of many disease states, having a detailed recording of the patient's pain journey is of utmost importance, and understanding that pain with further granularity can only help with the diagnosis of worsening disease, personalization of treatment, and outcomes assessment.

Eligibility criteria:
inclusion criteria: * patient over 18 years old exclusion criteria: * patient cannot use a smartphone * patient cannot use his hands to write or press a button * patient has a nerve catheter (has no pain) * altered mental status * neuropathy causing loss of pain sensation

Keywords: pain recorder device self-report