Kornimate/medical-research-clean huggingface dataset:
heart rate variability and prematurity

Conditions: Premature Birth; Maternal Distress - Delivered; Stress; Anxiety

Summary: mothers who deliver prematurely (\<37 weeks of gestational age) experience intense stress and anxiety given that their child's survival and development might be compromised. from the existing literature, it is known that a heart rate variability biofeedback (hrvb) program increases heart rate variability (hrv), which in turn, is related to significant reductions in perceived stress and anxiety. this study's aim is to evaluate the feasibility of an hrvb program in a sample of mothers who delivered prematurely.


Eligibility criteria:
inclusion criteria: * delivery between 33 and 37 weeks of gestational age * living in lausanne or surroundings * infant is expected to survive * singleton birth * consent of mother to participate in the study * sufficient french-speaking skills to fill out the questionnaires * mothers older than 18 years of age exclusion criteria: * infant with cranial abnormality/neurological squeal such as cystic periventricular leukomalacia (pvl) and intraventricular haemorrhage (ivh) * maternal history of drug or alcohol abuse or severe psychiatric disorders before or during pregnancy * infant with congenital anomalies * infant with hearing or vision loss * mother and infant participating in another clinical trial
rotateq™ post-marketing surveillance in the philippines

Conditions: Rotavirus Infections; Gastroenteritis

Summary: this study will collect demographic and safety information on the use of rotateq™ in the philippines.


Eligibility criteria:
inclusion criteria: * received rotateq™
measure of cerebrospinal fluid (csf) pressure variation with patient positioning

Conditions: Back Pain

Summary: this is a study looking at pressure changes in the fluid that surrounds the spine when a person is positioned in 2-3 different ways.

volunteers who need a myelogram of their spine as part of their routine medical care are being asked to be in this study. a myelogram is an imaging study with x-rays after an agent is put into the spine that shows spinal fluid on the x-ray. it requires insertion of a needle into the cerebrospinal fluid (csf) inside the spine. csf is a bodily fluid that bathes the brain, spinal cord, and nerve roots. this study is being conducted to measure csf pressure changes with different patient positioning. we are motivated to do this research study to better treat patients who develop a spinal fluid leak during a myelogram or other spine procedure. the tissue that holds the cerebrospinal fluid (csf) is called the dura. during surgery or other procedures, the dura can develop a tear. dural tears can result in a leakage of csf. csf leaks are a recognized complication of spinal surgery. currently, there is no evidence on whether or not a specific postoperative spine position is beneficial, especially for cervical (neck spine) csf leaks. the process of dural healing after a dural tear is influenced by csf pressure. high csf pressure may inhibit dural healing. we want to find the patient position (sitting, lying down, or reclining) that reduces the csf pressure the most. to do this, we want to attach a pressure monitor to the needle that is normally placed in the spine for a myelogram and measure the csf pressure.

Eligibility criteria:
inclusion criteria: * need a lumbar or cervical myelogram as part of routine care. exclusion criteria: * not needing a myelogram in the cervical or lumbar spine.

Keywords: cerebrospinal fluid pain in cervical spine pain in lumbar spine myelogram
docetaxel and gemcitabine with filgrastim-sd/01 support in patients with advanced non-small cell lung carcinoma

Conditions: Non-small Cell Lung Cancer

Summary: determine whether patients have a decreased incidence of grade 3 and grade 4 neutropenia when filgrastim-sd/01 is given with docetaxel and gemcitabine in patients with advanced non-small cell lung cancer.

docetaxel and gemcitabine given on day 1 and 8 of a 21-day schedule has substantial activity in non-small cell lung cancer. both first and second-line patients have response rates comparable to or better than other standard combination regimens. grade 3/4 neutropenia occurs in up to half of patients not given growth factor support. studies demonstrate that a single dose of filgrastim-sf/01 at 100 mg/kg effectively enhances post chemotherapy neutrophil recovery in a manner similar to that of daily filgrastim. this current study is designed to characterize the incidence of grade 3/4 neutropenia when a fixed dose of filgrastim-sd/01 is added to a well-studied myelosuppressive chemotherapy regimen consisting of gemcitabine and docetaxel.

Eligibility criteria:
* histologically or cytologically documented non-small cell lung cancer * subjects must have stage iv or iiib nsclc * 0-1 prior treatment regimens of chemotherapy * subjects must have bi-dimensionally measurable disease or evaluable disease by physical exam or radiological studies * age \> 18 years * 1st line - ecog 0-2 * 2nd line - ecog 0-1 * absolute neutrophil count \> or = 1.5 x 10 to the 9th power/l * platelet count \> or = 100 x 10 to the 9th power/l * adequate renal function with screening serum creatinine \< or = 2.0 mg/dl * adequate ast and alt no more than 1.5 x the upper limit of normal and serum bilirubin \< or = upper limit of normal * subjects must be at least two weeks from prior major thoracic or abdominal surgery and at least two weeks from completion of radiation therapy, and recovered from all toxicities associated with these treatments * negative hcg by urine or blood test in subject of child-bearing potential * life expectancy \> 2 months * ethical - before any study specific procedure is done or before study medication is administered, the subject or legally acceptable representative must give informed consent for participation in the study

Keywords: lung cancer, oncology, neutropenia, chemotherapy, filgrastim
developing and testing the effect of online interactive videos in improving low anterior resection syndrome.

Conditions: Rectal Cancer

Summary: this study aims to develop and test the effect of online interactive videos in improving lars.


Eligibility criteria:
inclusion criteria: 1. stage i-iii rectal cancer. 2. patients already know their condition. 3. aged 20 years and older. 4. consciously communicate in mandarin or taiwanese. 5. agreed with the interview and had signed the permit. exclusion criteria: 1. recurrent rectal cancer. 2. stage iv rectal cancer.
a prospective/retrospective,randomized controlled clinical study of interferon atomization in the 2019-ncov pneumonia

Conditions: 2019-nCoV

Summary: at present, there is no specific and effective antiviral therapy.in this study, an open, prospective/retrospective, randomized controlled cohort study was designed to compare the efficacy of two therapeutic schemes(abidol hydrochloride,abidol hydrochloride combined with interferon atomization)in the treatment of 2019-ncov viral pneumonia, so as to provide reliable evidence-based medicine for the treatment of viral pneumonia caused by 2019-ncov.


Eligibility criteria:
inclusion criteria: 1)2019-ncov nucleic acid test was positive. 2)ct of the lung conformed to the manifestation of viral pneumonia. exclusion criteria: 1. patients who meet any of the contraindications in the experimental drug labeling 2. patients who do not want to participate in this clinical study
efficacy and tolerance of telerobotic vs standard ultrasound exam in children

Conditions: Covid19

Summary: in children with covid-19, the diagnosis of kawasaki disease (kd) and pneumonia should be made very quickly. however, the regional hospitals surrounding paris don't have the required expertise. the use of melody allows the paediatric team to quickly carry out the necessary examinations while avoiding the movement of patients and the risk of contamination. the melody remote system developed by the company adechotech is a ce marking telemedicine technique, allowing an expert to perform an ultrasound scan on a distant patient (several hundred/thousands of kms). the melody system makes it possible to optimize ultrasound expertise resources wherever they are located (all specialties combined) the feasibility of the clinical use of telerobotic sonography has been demonstrated in adults for abdominal, cardiac and prenatal exam. thus, the aim of this study is to assess the feasibility of this system in children.


Eligibility criteria:
inclusion criteria: * patient from 1 year to 10 years * patient requiring an ultrasound exam (thoracic, abdominal or cardiac) * french social security affiliation exclusion criteria: * obesity defined by a bmi greater than 30 * open wound making it impossible to carry out an ultrasound scan * algetic patient * instability of vital functions * impossible to remain in a seated position * refusal to participate in the study
embark follow-up project

Conditions: Osteoarthritis of the Knee

Summary: the purpose of the embark follow-up project (efp) is to determine if there is a significant correlation between post-study massage-seeking and changes in pain reported by participants during the exploring massage benefits for osteoarthritis of the knee (embark) parent study (nct00970008). the efp hypothesizes that a positive correlation exists between pain relief during the parent study and post-study massage-seeking behavior.


Eligibility criteria:
inclusion criteria: * completed in the embark parent study. exclusion criteria: * did not complete the embark parent study.
effect of bnp (brain natriuretic peptides) on endothelial dysfunction induced by coronary angioplasty

Conditions: Coronary Artery Disease

Summary: patients receiving bnp or nitroglycerin (iv) during the angioplasty procedure. 24 h after the procedure, vascular reactivity will be re-examined using the brachial artery flow-mediated dilatation study. blood assays for et-1, pro-bnp, and various inflammatory markers will be checked before and 24 h after the procedure. it is our hypothesis that endothelial function will be better in the bnp treated patients compared to the ntg treated patients


Eligibility criteria:
inclusion criteria:coronary artery disease - exclusion criteria:chf and/or reduced lv function, or renal failure with creatinine \>2mg% -

Keywords: endothelial disfunction bnp pci coronary artery disease
nipple-areola complex (nac) irradiation after nipple-sparing mastectomy and reconstruction

Conditions: Breast Cancer; Ductal Carcinoma

Summary: the purpose of this research study is to see if a participant's nipple and areola can be safely preserved by adding radiation to these areas after a nipple-sparing mastectomy and immediate breast reconstruction.


Eligibility criteria:
inclusion criteria: * patients must have histologically confirmed in-situ or invasive breast carcinoma. * tis, t1, t2 invasive or non-invasive carcinoma of the breast; lesion less than 4 cm. * unifocal, multifocal or multicentric breast cancers that can be removed by nipple sparing mastectomy with negative surgical margins. * no extensive intraductal component or patient with distant metastases. * patients must be \> 18 years of age. * no concomitant or history of nipple discharge or skin involvement. * no prior history of malignancy (less than 5 years prior to study entry), except non-melanomatous skin cancer. * no prior history of radiation to the chest. * no collagenous disease (systemic lupus erythematosis, scleroderma, dermatomyositis)no previous non-hormonal therapy including radiation or chemotherapy for current breast cancer. * no patients with paget's disease of the nipple. * no patients with co-existing medical conditions with life expectancy \< 2 years. * no pregnant or lactating women. * eastern cooperative oncology group (ecog) 0 - 2. * signed study-specific informed consent form prior to the study entry. exclusion criteria: * retroareolar breast cancer lesions within one cm, depth from the skin surface. * concomitant or history of nipple discharge or skin involvement. * patient with distant metastases. * patient with extensive intraductal carcinoma. * any previously irradiated ipsilateral breast cancer. * patients with paget's disease of the nipple. * patients with collagenous diseases, as systemic lupus erythematosis, scleroderma or dermatomyositis. * other malignancy, except nonmelanomatous skin cancer, less than 5 years prior to participation in this study. * patients who are pregnant or lactating due to potential exposure of the fetus to rt and unknown effects of rt to lactating females. * positive surgical margins following nipple sparing mastectomy.

Keywords: breast cancer nipple area complex mastectomy radiation therapy nipple-sparing breast reconstruction
shamanic healing for women with temporomandibular joint disorders (tmds)

Conditions: Temporomandibular Disorders

Summary: this is a phase i study to examine the feasibility and safety of shamanic (spiritual) healing for treating temporomandibular joint disorders (tmds).

traditional systems of healing, such as shamanism, do not readily lend themselves to conventional research methods, yet studying their effectiveness is especially germane in the case of chronic conditions that involve an emotional component and that elude allopathic treatment regimens. temporomandibular joint disorders (tmds), which affect up to 10% of the adult population, are a prime example of such conditions. traditional treatment outcomes for tmd pain are often unsatisfactory. moreover, in women age 25-55 (the age-sex group most affected), tmd is often found in association with depression, anxiety, sleep disturbances, gastrointestinal symptoms, frequent infection,and fibromyalgia. because these multiple and complex symptoms suggest a loss of spirit or life energy, they may be particularly susceptible to treatment by shamanic (spiritual) healing, which aims to bring disturbed physical, mental, and emotional systems into balance. this phase i study will develop methods to evaluate shamanic healing as an intervention for tmd and will evaluate the feasibility of conducting randomized clinical trials of shamanic healing.

Eligibility criteria:
inclusion criteria: * females age 25-55 * tmd research diagnosis criteria (rdc) clinical diagnosis of myofacial pain with or without disc displacement, arthralgia, arthritis, or arthosis * three or more significant systemic conditions, e.g. depression, fibromyalgia, gi or reproductive disturbances, upper respiratory problems, etc. in the preceding 2 years. exclusion criteria: * diagnosed organic or medication induced major mental illness (e.g., schizophrenia, bipolar) * other neurological diagnoses (epilepsy, parkinsons) * pregnancy

Keywords: temporomandibular disroders shamanism chronic pain
cardiovascular autonomic neuropathy in patients with type 1 diabetes mellitus.

Conditions: Diabetes Mellitus, Type 1

Summary: testing of autonomic function and relationship with exercise and qol in diabetic patients and controls

cardiovascular autonomic neuropathy is a common (sub)clinical symptom in persons with type 1 diabetes mellitus. subjects in this non-commercial, monocentric, interventional study undergo autonomic function tests, a maximal ergospirometry and three questionnaires about the quality of life (eq-5d-3l), the capacity to do physical activities (ipaq) and the experience of possible symptoms of autonomic dysfunction in daily life (scopa-aut). in this way the influence of type 1 diabetes mellitus on the quality of life, the exercise capacity and the autonomic function can be studied. the primary aim of this study investigates the potential correlations between the severity of diabetic cardiovascular autonomic neuropathy (dcan) and both the quality of life and the exercise capacity. as a secondary aim, the influences of gender, age, number of years since diagnosis of type 1 diabetes mellitus, vo2 max predicted, maximal heart rate during exercise, minimal heart rate in rest, maximal rer (respiratory exchange ratio) and relevant interaction terms are studied. in total 52 test subjects with type 1 diabetes mellitus and 27 matched control subjects are selected to participate in this study.

Eligibility criteria:
inclusion criteria: * type 1 diabetes mellitus (only for the group of subjects with diabetes mellitus) * at least two years with diagnosis of type 1 diabetes mellitus * subject is in a stable condition * no hospitalization for any reason in the past three months * 18 years or older * being capable of doing physical activities * understand the study design and the informed consent * sign the informed consent * no simultaneously participation to another study * being capable of moving to the study center exclusion criteria: * uncontrolled hypertension, atrial fibrillation and other cardiovascular conditions * severe lung disease * muscle deficiency * medication with influence on the autonomic nervous system: * beta blockers * alfa blockers * antidepressants * non-catecholamines * (anti) cholinergic medication
impact of physical activity for chronic pelvic pain

Conditions: Pelvic Pain

Summary: the purpose of this pilot study is to evaluate the impact of an intervention to increase physical activity on pain, function and quality of life in women with chronic pelvic pain.

the primary aim of this pilot study is to evaluate the impact of moderate-intensity physical activity on pelvic pain in women with chronic pelvic pain. we will develop a moderate-intensity physical activity program for patients with chronic pelvic pain in conjunction with exercise physiologists and physical medicine and rehabilitation (pm\&r) physicians. based on prior research in fibromyalgia and other centralized pain disorders, we hypothesize that eight weeks of moderate-intensity physical activity will reduce pain intensity and pain interference in women with chronic pelvic pain. we will also evaluate the impact of moderate-intensity physical activity on physical function, fatigue, sexual function, sleep, anxiety, depression, catastrophization and patient global impression of change in women with chronic pelvic pain. we hypothesize that eight weeks of moderate-intensity physical activity will result in improvements in these measures of function and quality of life.

Eligibility criteria:
inclusion criteria: * female * 18-65 years old * ≥ 6 months of noncyclic pelvic pain * pain that is severe enough to cause functional limitations, defined here as an average self-reported daily pain score of 4 on a 10 point scale * willing to attend activity session in ann arbor, mi at least 3 times per week * english speaking exclusion criteria: * pelvic surgery within the previous 3 months or plan for pelvic surgery within the following 3 months * participation in pelvic floor physical therapy during the 12 week study period * medical co-morbidities that prohibit participation in an exercise program, such as significant cardiovascular, pulmonary or orthopedic disease * pregnancy * documented history of significant dementia

Keywords: chronic pelvic pain central pain amplification exercise physical activity
chest pain symptoms differences between diabetic patients and non

Conditions: Chest Pain; Diabetes Mellitus

Summary: cardiovascular disease is the most severe cause of death among all non-infectious diseases and accountable for 17.5 million deaths in the world. heart mortality in patients with dm is frequently associated with prevalence silent ischemia, which is triggered by autonomic neuropathy, thereby decreasing the chest pain felt by them


Eligibility criteria:
inclusion criteria: i) patients diagnosed with stemi and nstemi ii) both genders iii) above the age of 30 years iv) patients with acute myocardial infarction with or without chest pain (angina) for 24 hours v) patients who are hemodynamically stable vi) patients without acute decompensated heart failure (adhf) vii) patients without malignant arrhythmias viii) patients without in acute lung oedem (alo) condition ix) patients not using ventilator x) patient willing to and become respondents. exclusion criteria: i) patients with several complications, thereby making it impossible to interview them ii) patients who have never undergone cabg surgery iii) patients who refuse to be respondents
thrombus formation under different flow-conditions

Conditions: Thrombosis

Summary: rationale: cardiovascular diseases are important causes of morbidity and mortality in the industrialized world. clinical studies indicate an important role for the proteins of the contact activation system (coagulation factor xii (fxii), fxi, prekallikrein and high molecular weight kininogen (hmwk)) on the risk of cardiovascular disease. there is substantial evidence from mouse studies that fxii and fxi participate in the formation and stability of thrombi and in vitro studies showed that collagen is able to activate fxii and hereby stimulate thrombin formation and potentiate the formation of platelet-fibrin thrombi. the investigators want to determine the role of the proteins of the contact activation system in platelet mediated thrombus formation in human blood. objective: the investigators will study the effects of the proteins of the contact activation system on platelet mediated thrombus formation, embolization and degradation on collagen in a perfusion flow model. study design: blood will be collected from human volunteers via a venipuncture in the forearm. each volunteer will donate maximally four times 30 ml of blood over a period of two days. this blood is used in perfusion flow experiments: blood flows over a coverslip covered with collagen in a flow chamber. the investigators will vary several conditions such as the concentration of the proteins and the shear rate. for perfusion flow experiments, the investigators need fresh whole blood because platelets are viable for four hours. after this time, new blood is needed. study population: for this study the investigators need blood from human volunteers with a coagulation defect in one of the proteins of the contact activation system, e.g. fxii, fxi, prekallikrein or hmwk and controls without any coagulation defects. main study parameters/endpoints: the investigators main study endpoint is the ex vivo formation of platelet-mediated thrombi on collagen in a perfusion flow model. the investigators hypothesize that thrombi formed from blood of patients deficient in fxii or fxi are less stable than those formed from blood from controls.


Eligibility criteria:
inclusion criteria: * patient group: * age: ≥ 18 years * deficiency in factor xii, factor xi, prekallikrein or high molecular weight kininogen * control group: * age: ≥ 18 years exclusion criteria: * (other) coagulation defects * symptoms of active disease * the use of antiplatelet drugs * the use of aspirin/ascal

Keywords: thrombosis blood coagulation perfusion flow experiments factor xii factor xi prekallikrein high molecular weight kininogen