Kornimate/medical-research-clean huggingface dataset:
cardiomyocyte injury following acute ischemic stroke

Conditions: Stroke, Ischemic; Cardiac Complication

Summary: the primary goal of the corona-is study is to characterize stroke-associated acute myocardial injury (elevated hs-cardiac troponin) using different diagnostic examinations in order get a better understanding of it's underlying pathomechanisms.

myocardial injury (i.e. elevated cardiac troponin levels) is a frequent cardiac complication during the first few days after an ischemic stroke and is associated with a poor functional outcome. myocardial injury represents one essential part of a broad spectrum of cardiac complications ranging to severe arrhythmia or heart failure. there is evidence that, in the majority of patients, the underlying mechanism of stroke-associated myocardial injury is not coronary-mediated myocardial ischemia but rather stroke-induced functional and structural interference in the central autonomic network. the investigators hypothesize that this causes a dysregulation of normal neuronal cardiac control leading to myocardial edema and stunning ('stroke-heart-syndrome') corona-is is a prospective, observational, single-centered cohort study that will recruit 300 patients with acute ischemic stroke. according to serial high sensitivity ctn levels during the first 24h after admission, patients will be assigned to three groups (no myocardial injury, chronic myocardial injury, acute myocardial injury). study procedures include cardiovascular mri and transthoracic echocardiography to visualize (transient) cardiac dysfunction and provide detailed tissue characterization, 20-minute holter-monitoring with an analysis of specific autonomic markers, and a systematic bio-banking to study further mechanisms such as altered microrna signatures. a follow-up for cardiovascular events will be conducted one year after enrolment to study long-term effects of stoke-associated myocardial injury. the aim of the corona-is study is to develop a better understanding of the characteristics and the pathophysiology of stroke-induced acute myocardial injury ('stroke-heart-syndrome') in order to identify patients at risk and improve diagnostic and therapeutic procedures.

Eligibility criteria:
inclusion criteria: * age over 18 * diagnosis of acute ischemic stroke and hospital admission within 48h after onset of the symptoms * diagnosis based on visible dwi-lesion in mri * written informed consent by participant * repeated measurement of high sensitive troponin t within 24h of admission (hs-troponin t, roche elecsys®, 99. percentile, upper reference limit=14ng/l) exclusion criteria: * pregnancy and / or breast-feeding. * impaired renal function (egfr \< 30 ml/min/1,73 m\^2) * contraindications to undergo mri (i.e., mechanic heart valve, cardiac pacemaker, etc.) * persistent or permanent atrial fibrillation * st- elevation myocardial infarction * history of coronary artery bypass surgery or percutaneous trans-luminal coronary angioplasty (ptca) ≤ four weeks

Keywords: stroke stroke-heart syndrome troponin myocardial stunning acute coronary syndrome periodic repolarization dynamics cardiac complications
milk versus a pea-based beverage for bone and muscle health in young athletes

Conditions: Muscle Atrophy

Summary: canada's food guide places an increased emphasis on plant-based proteins; however, canadians who consume a plant-based diet may be compromised because of intake of lower-quality protein. consumption of high-quality protein is important during growth and development, especially in highly active individuals. the study will compare milk (i.e. high quality protein) to a pea-based beverage (i.e. lower quality plant-based protein) in adolescent boys and girls who are engaged in resistance-training programs as part of their athletic training. one-hundred and fourteen adolescent boys and girls (12-17y of age) will be divided into groups that consume milk, a pea-beverage, or a carbohydrate (sugar) beverage after resistance training sessions performed three times per week for six months. it is predicted that the group consuming milk will have greater increases in muscle mass, strength, and bone density, and greater reductions in fat mass compared to the groups consuming a pea-based or carbohydrate beverages.

milk protein is important especially for very active people and in the context of plant-based diets, which are lower in protein quality. the purpose of the study is to compare the effectiveness of milk supplementation to pea-beverage supplementation during resistance training programs for increasing lean tissue mass in adolescent boys and girls. secondary and tertiary outcomes include fat mass, bone mineral density, and muscular strength. it is hypothesized that milk supplementation during resistance training will be more effective than plant-based proteins (i.e. pea-beverage) for increasing muscle mass, reducing fat mass, and improving bone mineral outcomes in adolescent boys and girls. one-hundred and fourteen boys and girls (aged 12-17y) who are currently enrolled in resistance training programs (3 times per week for 6 months) as part of their competitive athletic programs will be stratified by sex and maturity status before being randomized to three groups: 1) 1% chocolate milk supplementation; 2) pea-based beverage; 3) carbohydrate beverage (placebo control). beverages will be consumed during recovery from each resistance training session (i.e. 250 ml immediately after training and 250 ml one hour later to optimize post-exercise protein synthesis) over the six-month intervention. it is anticipated that milk supplementation will be more effective than plant-based protein supplementation.

Eligibility criteria:
inclusion criteria: * currently participating in a resistance-training program 3 times per week * female participants must have reached menarche exclusion criteria: * have taken any nutritional supplement (e.g., protein, creatine, amino acids) within the past month * currently taking anabolic steroids or oral corticosteroids * allergies to dairy, almonds, cashews, or peas
standard patient training versus vik chatbot guided training: a randomized controlled trial for asthma patients

Conditions: Asthma

Summary: the onset of smartphone usage has provided new opportunities for managing patients outside the walls of healthcare facilities. the development of asthma-specific smartphone applications represents an excellent area for partnership between developers and medical teams for delivering therapeutic education at the required time and in a personalised way. within this context, the overall goal of the asthmatrain study is to perform a first, small pilot study comparing a new french-language chat-bot guided asthma patient education programme (the 'vik' application) with the classic, authority-approved patient education program at the university hospitals of montpellier, montpellier, france. the primary objective is to compare a population of adult patients with asthma and participating in a standard patient education programme with a similar population participating in vik-guided education programme in terms of change in overall scores on the asthma quality of life questionnaire (aqlq).

secondarily, the following will also be compared between the two study arms: * the subdomains of the aqlq score, * lung function, overall asthma control and exacerbation rates, * general health status via the euroqol 5-domain 5-level questionnaire (eq-5d-5l), * adherence to the program and burden of the program for the medical team, * major categories of direct health resource consumption. finally, because education intervention success may depend on patient-specific characteristics, an ancillary study will compare the following baseline traits between the 50% best intervention responders in either arm: * the big five personality traits, * the hospital anxiety and depression, * coping mechanisms.

Eligibility criteria:
inclusion criteria: * minimum age: 18 * physician-confirmed diagnosis of asthma exclusion criteria: * protected populations according to the french public health code articles l1121-6,8 * the subject has already participated in the present study * subject unable to comply with trial procedures/visits * potential for interference from another study * non-beneficiary of the french single-payer national medical insurance system * lack of informed consent * patients already using the vik asthma application in their daily lives or having already followed a therapeutic education program

Keywords: chatbot patient education
the effect of spinal mobilization on respiratory parameters in parkinson's disease patients

Conditions: Parkinson Disease; Camptocormia; Restrictive Lung Disease

Summary: parkinson's patients suffer from respiratory distress for different reasons. it is thought that physiotherapy methods that have an indirect effect on the diaphragm can improve respiratory functions. the aim of this study is to investigate the effects of spinal mobilization and diaphragmatic breathing techniques on respiratory function.

respiratory complications are one of the most common causes of death in parkinson's patients. camptocormia may develop in parkinson's disease and other pathological conditions involving the basal ganglia, which can be defined as an abnormal flexion of the thoracolumbar spine of 45° or more, which increases during walking or standing and disappears completely in the supine position. parkinson's patients with camptocormia often complain of dyspnea, which can be attributed to reduced lung capacity due to limited chest expansion. restrictive changes due to respiratory muscle dysfunction in parkinson's disease, upper airway obstruction, abnormal ventilatory control, and drug use such as levodopa have an effect on respiratory functions. restrictive dysfunction has been reported in 28-94% of patients with parkinson's. postural disorders such as camptocormia can also lead to restriction. one study found that the lung volumes of parkinson's disease patients with camptocormia decreased, although it was not associated with major clinical changes. diaphragmatic dyskinesia in parkinson's patients may also lead to a restrictive deterioration in respiratory functions. studies examining the effects of chest and diaphragm mobilization on spirometric parameters in patients with cerebral palsy reported that the applied mobilization and soft tissue techniques improved fev1 and fvc. the effect of indirect diaphragmatic treatments with vertebral mobilization in individuals with parkinson's who are at risk of experiencing restrictive respiratory problems is unknown. the aim of this study is to examine the effects of spinal mobilization techniques for the diaphragm on respiratory function parameters and posture.

Eligibility criteria:
inclusion criteria: * have been diagnosed with parkinson's disease * volunteering to participate in the study * modified medical research council (mmrc) score \>2 exclusion criteria: * those with covid-19 * diseases that increase intra-abdominal pressure * diseases affecting diaphragmatic motility * those who had a recent thoracic or abdominal operation * those who have a parenchymal, pleural or chest wall mass that will cause restriction on a recent chest x-ray or ct will not be included in the study

Keywords: rehabilitation posture
discontinuation from chronic opioid therapy for pain using a buprenorphine taper

Conditions: Chronic Pain; Opioid Pain Medication

Summary: chronic opioid therapy for pain can be associated with significant risks, and a significant number of patients maintained on chronic opioids have continued pain and/or poor functioning. when patients need to or want to come off their opioid pain medications, there is little to guide physicians as to how to best help them do so, and it is not known how patients do after coming off opioid medications. the goals of this study are (1) to evaluate two medications in assisting patients in coming off their opioid pain medications and (2) determining outcomes after discontinuing opioids.


Eligibility criteria:
inclusion criteria: * 18 - 70 years of age * ability to speak and read in english * currently taking chronic opioid therapy for pain for at least 6 months * on opioid dose of \>60mg and \<200mg oral morphine equivalents/day * voluntarily seeking opioid discontinuation * willing to attempt buprenorphine-assisted opioid discontinuation * willing to be randomized to gabapentin or placebo * have current physician who is actively prescribing opioids and who will be notified by the research team of the patient's entry into the study. exclusion criteria: * previous intolerance or allergy to buprenorphine or gabapentin * diagnostic \& statistical manual -v criteria for substance use disorder currently or in the past (other than nicotine) * unstable medical or psychiatric condition that would preclude safe or meaningful participation (e.g. traumatic brain injury; severe mental illness; severe cardiac, renal, pulmonary, or liver disease) * current use of illicit drugs * maintenance on fentanyl or methadone * current treatment with gabapentin
a study of alks 9072 in subjects with chronic stable schizophrenia

Conditions: Schizophrenia

Summary: this study will determine the pharmacokinetics (pk), safety, and tolerability of alks 9072 (also known as alks 9070) after 4 monthly doses in adults with chronic stable schizophrenia.

three active treatment groups and a placebo group are planned. randomization will be sequential by dose level across the sites with placebo assignments randomly inserted. each subject's participation will be approximately 8 months, including screening, treatment period, and a 3-month follow-up period.

Eligibility criteria:
inclusion criteria: * diagnosis of chronic schizophrenia that is clinically stable * body mass index (bmi) between 18.5 and 35.0 kg/m2, inclusive * stable antipsychotic medication regimen for \>/= 2 months before screening * be willing and able to be confined to an inpatient clinical research unit for a total of 37 days during the course of the study exclusion criteria: * aripiprazole used within 30 days before screening * history of intolerance of or allergy or hypersensitivity to aripiprazole, its excipients, other antipsychotic agents, or intralipid (including peanuts, soy, egg, or glycerol) * current diagnosis of an axis i disorder other than schizophrenia * history of seizure disorder or any condition associated with seizures * history of neuroleptic malignant syndrome (nms) * positive test result for hiv, hepatitis b surface antigen, or anti-hepatitis c antibodies * received medication by im injection within 30 days before screening * monoamine oxidase inhibitors (eg, phenelzine, tranylcypromine, selegiline) used within 30 days before screening * dsm-iv-tr diagnosis of alcohol or substance dependence, with the exception of nicotine or caffeine dependence within 12 months before screening * donation of blood or blood components within 4 weeks before screening
visual outcome after transsphenoidal surgery for pituitary macroadenoma

Conditions: Pituitary Tumor; Optic Chiasm Disorder

Summary: endoscopic endonasal transsphenoidal surgery is a procedure for the treatment of pituitary macroadenomas that cause visual impairment through optic chiasm compression. the aim of this retrospective study is to describe visual outcome after this procedure.


Eligibility criteria:
inclusion criteria: * pituitary tumor causing optic chiasm compression (documented on mri or ct-scan) * visual impairment caused by chiasm compression * treatment by transsphenoidal endonasal surgery * treatment in the rothschild foundation (paris) between 2009 and 2013 exclusion criteria: * ophtalmologic condition other than optic chiasm compression
plaque removal by triple-headed manual toothbrush

Conditions: Plaque, Dental

Summary: this randomized controlled trial aimed to determine the effectiveness of a plaque removal by triple-headed manual toothbrush by comparing changes in rustogi modifiye navy plaque index. participants will be divided into two groups and will be made to brush with different designed toothbrushes. the researchers will compare the plaque removal efficiency of the brushes by comparing the changes in the plaque index of the intervention and control groups before and after brushing.


Eligibility criteria:
inclusion criteria: * age ranging from 18-60 years; * a minimum of 12 teeth; * participants were wanted to be right-handers when toothbrushing to standardization. exclusion criteria: * patients with systemic illnesses or conditions, * smokers and individuals taking any medication that may affect periodontal health were not included in the study. * individuals who had previously been treated for periodontal disease in the past 6 months were also excluded.

Keywords: oral hygiene rustogi modifiye navy plaque index modified bass technique toothbrush dental plaque
early rheumatoid arthritis cor intervention

Conditions: Rheumatoid Arthritis; Cardiovascular Diseases

Summary: the primary aim of our present study is to evaluate the effect of a targeted, intensified, multidimensional intervention compared to conventional treatment of modifiable risk factors for cvd in patients with early ra. the primary endpoint, a composite of death from cardiovascular causes, non-fatal mi, non-fatal stroke and re-vascularisation, will be assessed after 5years' follow-up.

the study is a prospective randomised open, blinded endpoint trial with balanced randomisation (1:1) conducted in seven outpatient clinics in denmark. follow-up visits for patients in the intervention group are scheduled to occur at baseline and then after 2, 4 and 12 weeks and thereafter every third month for 5 years after randomisation. the control group will be monitored for ra disease activity and comorbidity after 2, 4 weeks, 12 weeks and thereafter following national guidelines for ra. prevention of cvd risk factors in the control group will be treated in general practice according to national guidelines for diabetes (2011), hypertension (2009) and cvd (2013).

Eligibility criteria:
inclusion criteria: * ra according to the revised american college of rheumatology (acr) 2010 criteria and plasma ldl \> 2.5mmol/l. exclusion criteria: * pregnancy * lactation * ongoing/previous dmard therapy * ongoing/previous steorid therapy * contraindication to any of the trial drugs * current infection with parvovirus b19, hepatitis b, hepatitis c or human immune deficiency virus. previous report of hospitalisation for myocardial ischaemia defined as follows: a) non-fatal myocardial infarction (mi) defined according to national and international guidelines. b) acute coronary syndrome (acs) including acute ischaemic symptoms with possible biomarker changes or elctrocardiographic changes that to not meet the criteria for mi, c) angina pectoris, d) revascularisation (percutaneous coronary intervention (pci) or coronary artery bypass grafting (cabg).
transcranial magnetic stimulation for depression in autism spectrum conditions

Conditions: Autism Spectrum Disorder; Major Depressive Disorder

Summary: in this research study the investigators aim to learn more about the therapeutic effects of a newer form of non-invasive transcranial magnetic stimulation (tms), called theta burst simulation (tbs), on refractory depression in autism spectrum conditions.

the overarching goal of this study is to examine treatment effects and elucidate the physiological biomarkers of a newer form of non-invasive brain stimulation therapy on refractory depression in a sample of participants with asc (autism spectrum condition). aim 1: to compare the efficacy of 30-sessions of bilateral (bl) versus unilateral (ul) theta burst stimulation to the dorsolateral prefrontal cortex (dlpfc) on depression severity in youth/young adults with asc and co-occurring refractory major depressive disorder (mdd). aim 2: to identify physiological markers of target engagement of successful response to either ul or bl on depression severity in youth with asc and co-occurring refractory mdd. these physiological markers include high-resolution electroencephalography (eeg) markers, social eye-tracking, and handgrip strength (collected via nih toolbox's motor toolbox domain). aim 3: to identify feasibility of bl and ul in participants with asc including systematic measures of safety and tolerability. this includes clinical measures such as rate of hospitalization and medication use.

Eligibility criteria:
inclusion criteria: * have been diagnosed on the autism spectrum * have been diagnosed with depression and have failed one or more evidence-based antidepressant treatments (e.g. a selective serotonin reuptake inhibitor, talk therapy like cognitive behavioral therapy) * do not have an intellectual disability exclusion criteria: * substance use disorder * presence of metallic foreign bodies or implanted medical devices * history of epilepsy * prior rtms treatment * for female subjects of child bearing potential, current pregnancy

Keywords: transcranial magnetic stimulation tms mdd asd tbs theta burst stimulation autism depression
assessment of adenoidal obstruction in children : clinical signs versus flexible nasal endoscopy and roentgenographic findings

Conditions: Obstructive Sleep Apnea; Nasal Obstruction

Summary: the term adenoids describes lymphoid tissue on the superior and posterior walls of the nasopharynx, and their hypertrophy is a common condition of childhood. when enlarged, adenoids can obstruct the nasopharyngeal airway and cause mouth-breathing, hyponasal voice, and snoring. in more severe cases, obstructive sleep apnea (osa) may result, which carries potential risk of neurocognitive disturbance, growth failure, and heart-lungs disease. adenoid hypertrophy can also be associated with otitis media with effusion, possibly through eustachian tube dysfunction or chronic adenoidal infection. methods for identification of adenoid hypertrophy include the clinical history, examination, imaging (eg, plain lateral x-ray), or by nasal endoscopy witch enable direct visualization of the nasal cavity with dynamic evaluation of any nasal airway obstruction. objectives : the aim of this study is to prospectively examine invasive and non-invasive office procedures to assess adenoids hypertrophy, including clinical history, x-ray imaging, and nasal endoscopy. methods : prospective, observational study in pediatric patients aged 2-18 that will be referred to the otolaryngology pediatric 'clalit' clinic in haifa after x-ray imaging and an informed consent. 1. nasal obstruction index (noi) the noi questionnaire for history and physical exam will be evaluated at the clinic, as described by paradise grading system. 2. plain lateral x-rays plain lateral x-rays of the patients will be evaluated only if the patients had them at the time of referral. adenoidal obstruction will be assessed by fujioka's adenoid-nasopharynx ratio. 3. fiberoptic nasal endoscopy (fne) fiberoptic analysis will be done as an office procedure using a 2.4mm storz nasal flexible endoscope following an application of lidocaine gel locally into the nostril and on the endoscope distal end. adenoidal obstruction will be assessed by parikh grading system.


Eligibility criteria:
inclusion criteria: * age 2-18 * performed lateral cervical radiograph * nasal obstruction * signed informed consent by caregiver exclusion criteria: * previous adenoidectomy * recent upper airway infection * anatomic anomaly * allergic rhinitis * known obstructive sleep apnea

Keywords: obstructive sleep apnea pediatric adenoid hypertrophy