Kornimate/medical-research-clean huggingface dataset:
analysis of the different strategies for revascularization of the lower limbs by peripheral angioplasty

Conditions: Peripheral Arterial Disease; Angioplasty

Summary: peripheral arterial disease (pad) caused by atherosclerosis causes damage to the arteries originating in the aorta (descending) from the iliacs to the extremities of the lower limbs. it causes significant morbidity and mortality. percutaneous revascularization plays a key role in the management of these patients. many percutaneous treatment options have been developed: arteriectomy, naked stents, active balloons and active stents. of these, only paclitaxel-active stents were successful in reducing the rates of restenosis and reoperation in patients with superficial femoral artery injury.the main objective is to study symptomatic improvement at 1 year of patients treated with revascularization of the lower limbs.


Eligibility criteria:
inclusion criteria: * patient treated by the peripheral angioplasty department of claude galien hospital from january 2010 and with at least 1 year of follow-up after the revascularization procedure * patient treated for symptomatic chronic ischemia of the lower limbs defined by rutherford categories 2-4 and / or leriche stage greater than 2a * stenosis or restenosis (history of balloon angioplasty, active balloon or bare stent) * degree of stenosis ≥ 50% by angiographic evaluation visual, by ct scan or by doppler ultrasound * patient affiliated or beneficiary of a social security scheme * patient aged 18 or over * patient having been informed and not opposing this research exclusion criteria: * medical history of myocardial infarction or stroke within 3 months of the revascularization procedure * unstable angina at the time of the revascularization procedure * sepsis at the time of the revascularization procedure * major under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision * hospitalized without consent * pregnant, breastfeeding or parturient woman
effectiveness of parents' manipulation in newborn with talipes calcaneus

Conditions: Talipes Calcaneovalgus

Summary: the purpose of this study is to determine effectiveness of parents' manipulation in newborn with talipes calcaneovalgus over observation group.

talipes calcaneovalgus is one of the common foot deformity in newborn. most of patients can be cure without specific treatment. manipulation was easy method that parents can preform by their own and may be beneficial in speeding resolution of deformity.

Eligibility criteria:
inclusion criteria: * all newborn with talipes calcaneovalgus exclusion criteria: * patient associated with congenital musculoskeletal anomaly * patient with other serious medical condition

Keywords: tcv
evaluation of the emergency imaging strategy for the diagnostic management of renal colic

Conditions: Renal Colic

Summary: emergency imaging is necessary for the diagnostic management of renal colic in the emergency department. ultrasound is rapidly available and non-irradiating, allowing to look for a stone and a pyelocalic dilatation. but it is less sensitive when the stone is ureteral. ct has a sensitivity of 96% and a specificity of 100%. the latest french recommendations date from 2008, recommending ultrasound and an unprepared abdomen in cases of uncomplicated renal colic. for the european society of radiology, ultrasound should be the first-line examination. the place of a systematic ct scan as first-line examination for the diagnosis of renal colic in the emergency department is therefore still under discussion. an evaluation of practice will make it possible to assess the imaging strategy applied in an emergency department.


Eligibility criteria:
inclusion criteria: * major subject (≥18 years) * subject who was managed in the nhc emergency department from july 01, 2018 to june 30, 2019 with a final diagnosis of renal colic diagnostic * subject who has not expressed opposition, after information, to the reuse of their data for the purpose of this research exclusion criteria: * subject who has expressed opposition to participating in the study * subject under guardianship or curatorship * subject under legal protection

Keywords: renal colic nephritic colic pyelocalic dilatation
study to compare the effect of ipilimumab retreatment with that of chemotherapy in advanced melanoma

Conditions: Melanoma

Summary: the purpose of the study is to determine whether additional doses of ipilimumab have a positive effect on survival in the treatment of advanced melanoma that has progressed after successful initial treatment with ipilimumab.


Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com. key inclusion criteria: * histologic diagnosis of unresectable stage iii or iv metastatic melanoma * prior ipilimumab induction treatment (3 mg/kg) * documented disease control \[stable disease ≥3 months or partial response/complete response\] after ipilimumab induction * documented progressive disease following disease control key exclusion criteria: * patients with brain metastasis are excluded, unless they are free of neurologic symptoms related to metastatic brain lesions and do not receive systemic corticosteroid therapy for the purpose of reducing intracranial inflammation in the 10 days prior to beginning retreatment with ipilimumab * any intervening anticancer therapy between last dose of ipilimumab induction and ipilimumab retreatment on study * patients who experienced any grade 3 immune-related adverse event (irae) (except for endocrinopathies where clinical symptoms were controlled with appropriate hormone replacement therapy) or any grade 4 toxicity during prior treatment with ipilimumab * patients with a prior irae that has not improved to grade 1 or better at randomization
study of ombitasvir/paritaprevir/ritonavir in japanese adults with genotype 1b chronic hepatitis c virus (hcv) infection with end stage renal disease (esrd) on hemodialysis (hd)

Conditions: Chronic Hepatitis C Virus

Summary: the purpose of this multicenter, single-arm, combination-drug study, which includes 12 weeks of treatment and 24 weeks of follow-up, is to evaluate the safety, efficacy and pharmacokinetics of ombitasvir/paritaprevir/ritonavir in japanese adults infected with hcv gt1b, who are treatment-naïve or treatment-experienced to an ifn-based regimen and who have esrd on hd.


Eligibility criteria:
inclusion criteria: * females must be practicing specific forms of birth control on study treatment, or be post-menopausal for more than 2 years or surgically sterile * hepatitis c virus (hcv) ribonucleic acid (rna) greater than 10,000 iu/ml at screening * chronic hcv, genotype (gt)1b infection * treatment-naive or treatment-experienced with an interferon (ifn)-containing regimen (ifn or pegylated-ifn with or without ribavirin). * a fibrosis assessment test result equivalent to metavir f0-f2. exclusion criteria: * presence of y93h variant at screening * positive test result for hepatitis b surface antigen (hbsag) or anti-human immunodeficiency virus antibody (hiv ab) * significant liver disease with any cause other than chronic hcv infection * on peritoneal dialysis * on hemodialysis for more than 15 years

Keywords: non-cirrhotic end stage renal disease (esrd) moderate fibrosis chronic hepatitis c virus ( hcv) chronic hepatitis c genotype 1b
perioperative analgesia using ultrasound (us) guided transversus abdominis plane (tap) block

Conditions: Postoperative Pain

Summary: perioperative analgesia using us guided tap block

perioperative analgesia using us guided tap block

Eligibility criteria:
inclusion criteria: * adult undergoing laparoscopic cholecystectomy exclusion criteria: * history of cardiorespiratory disease
antegrade and retrograde versurs antegrade cardioplegia in complex coronary artery bypass surgeries

Conditions: Coronary Artery Disease Left Main

Summary: during coronary artery bypass surgery, myocardial protection, especially of the right ventricle, may be inadequate in the presence of severe coronary lesions that obstruct the antegrade delivery of cold cardioplegia

asymetric myocardial cooling has been reported to yield postoperative right ventricular dysfunction, which may contribute to postoperative morbidity and mortality. retrograde coronary sinus perfusion was introduced in 1956 to facilitate surgery involving the aortic valve. this technique was introduced as a means of myocardial protection for coronary artery bypass surgery in 1967 and has recently received renewed interest. an innovative method of delivering retrograde cardioplegia through the right atrium was recently developed by fabiani and associates. this technique has obviated the need to directly cannulate the coronary sinus and thus has eliminated concerns regarding coronary sinus rupture due to cannulation, and concerns of inadequate right ventricular perfusion. in contrast to antegrade delivery, retrograde delivery of cardioplegia through the right atrium is not subject to the problem of limited distribution in the presence of coronary artery occlusive disease and thus allows more uniform cooling of the left ventricle,so the study will compare the results of combined antegrade and retrograde versurs antegrade cardioplegia in complex coronary artery bypass surgeries

Eligibility criteria:
inclusion criteria: * age between 18 and 60 years * lv ejection fraction between 30 and 50% * left main stem cad * mitral or aortic valve disease associated with ischemic heart disease exclusion criteria: * double valve disease or other valve disease * mitral or aortic valve disease associated with congenital heart disease * patients subjected to prior heart surgery * emergency operation * poorly controlled diabetes mellitus
evaluation of the efficacy of high doses of methylprednisolone in sars-cov2 ( covid-19) pneumonia patients

Conditions: Covid19

Summary: this double blind, randomized study is aiming to evaluate the efficacy of three doses (1gr/day) of methylpredisolone added to standard therapy in patients, with documented covid-19 pneumonia, requiring hospitalization but not mechanical ventilation.

patients recently hospitalized for the treatment of documented covid-19 pneumonia who do not require invasive ventilation will be randomized (1:1) to receive current standard treatment, which may include desamethasone and oxygen, with methylprenisolone 1gr daily iv for 3 consecutive days or standard treatment alone. efficacy measures will be time to recovery (discharge from hospital), invasive ventilation prevention and survival. patients safety will be evaluated throughout the all study period.

Eligibility criteria:
inclusion criteria: 1. age = 18 years; 2. informed consent for participation in the study and for data processing; 3. molecular diagnosis with polymerase chain reaction (pcr) test of sars-cov2 infection; 4. hospitalization in a specialist ward for covid-19 patient care (eg., infectious diseases, pulmonology or internal medicine); 5. need for supplemental oxygen in any delivery mode with the exception of invasive mechanical ventilation; 6. pao2 / fio2 between 100 and 300 mmhg. 7. clinical / instrumental diagnosis (high resolution chest ct scan or chest x-ray or lung ultrasound) of interstitial pneumonia for no more than three days; 8. serum crp greater than 5 mg / dl; 9. interval from onset of sars-cov2 infection symptoms to randomization\> 5 days- exclusion criteria: 1. invasive mechanical ventilation; 2. presence of shock or concomitant organ failure that requires admission to the intensive care unit; 3. pregnancy or breastfeeding; 4. severe heart or kidney failure; 5. known hypersensitivity to methylprednisolone, to dexamethasone or to an exception; 6. diabetes not compensated according to the doctor's judgment; 7. other clinical conditions that contraindicate methylprednisolone and cannot be treated or resolved according to the doctor's judgment; 8. steroid bolus therapy in the week prior to enrollment for the study; 9. enrollment in another clinical trial; 10. patient already randomized in this study-

Keywords: covid19 methylprednisolone
neurophysiological evaluation of schizophrenia patients after cognitive and physical intervention

Conditions: Schizophrenia

Summary: neurophysilogical, neuropsychological evaluation and cognitive and physical training

24 sessions (8 weeks, 3 times per week) of cognitive and physical training via computer. each session consisted of 45 minutes of cognitive traing (brainhq platform https://www.brainhq.com/) and 45 minutes of physical training (fitforall platform https://www.fitforall.gr/play/app/). cognitive training included memory, attention, velocity, intelligence etc. physical training included aerobic, strength flexibility and other excercises. all evaluations were performed 1-14 before the initiation of the interventions and 1-14 after their completion. neurophysiological evaluation consisted of eeg with the use of 128 electrode-machine and the protocol included 5 minuted of eyes closed and 5 minutes of eyes open. neuropsychological evaluation included trail making test (a \& b), verbal fluency, stroop test, wechsler memory - cubes (visuospatial), moca, fab (screening for frontal damage) and eyes test (theory of mind). also, the physical condition evaluation included 6-minute walking distance (6mwd), βμι, handgrip strength test, short physical performance battery protocol.

Eligibility criteria:
inclusion criteria: * a diagnosis of schizophrenia disorder according to icd10 criteria * clinically stable patients (no recent change in psychotropic medication except benzodiazepines) * sufficient acculturation and fluency in greek language * assent of the attending physician for participation in the study exclusion criteria: * co-morbidity with neurological disorders (e.g.epilepsy) or head injury * a pathological or other somatic disorder that contraindicate physical exercise * alcoholism and substance abuse within the previous 3 months (except caffeine and tobacco) * abstainance from intervention for more than 12 days * cognitive decline * treated with benzodiazepine

Keywords: electroencephalography cognitive training physical training resting state networks
weight stigma by association in parent-child dyads

Conditions: Childhood Obesity; Obesity

Summary: parents of children with obesity report feeling blamed for their children's weight and reluctant to seek pediatric care after stigmatizing experiences. this "weight stigma by association" may have direct consequences for parents, children, and the parent-child relationship. the present study builds on qualitative evidence to experimentally test weight stigma and weight stigma by association in a parent-child relationship using a large, community-based sample. in an experiment conducted via an online survey, participants were randomly assigned to view a picture of a parent-child dyad, for which parent and child's gender (male vs. female) and weight status (with obesity vs. without obesity) were manipulated. participants read identical general parenting descriptions that adhered to american academy of pediatrics parenting recommendations, then rated the parent's effectiveness, helpfulness, and caring.


Eligibility criteria:
inclusion criteria: * at least 18 years of age exclusion criteria: * standard exclusion criteria were duplicate ip addresses, response times \ 3600s (the allotted time to complete the survey), or failure to complete the parenting questionnaire.

Keywords: childhood obesity weight stigma by association parenting
efficacy study of memantine hydrochloride and escitalopram for the treatment of co-morbid depression and alcoholism.

Conditions: Alcoholism; Depression

Summary: the aim of the present study was to examine the influence of memantine, a noncompetitive nmda receptor blocker, in depression co-morbid with long term alcohol heavy use comparing to ssri-inhibitor, escitalopram. second goal is to compare their influence to cognitive tasks and the third goal is to follow up alcohol-use with these two medicines.

context depression is common clinical problem among alcoholics and its treatment has no standard and is controversy. glutamate nmda-receptors may mediate the effects of long term alcohol related depression and thus the nmda-receptor modulator memantine could have effects on it. objectives the preliminary aim of this study was to identify possible new treatment for depression of alcoholics and compare the efficacy of escitalopram and memantine in co-morbid depression of alcoholism. design and setting double-blind, randomized, naturalistic study, 26-week trial on alcohol dependent outpatients. participants eighty alcohol dependent depressive adults intervention subjects were randomized 1:1 to receive memantine or escitalopram 20 mg per day. during the study the patient received routine psychosocial treatment at a-clinic. no concomitant intervention on alcohol consumption and no imposed treatment goals. the patients were met weekly in first month, then after 3 and 6 months.

Eligibility criteria:
inclusion criteria: 1. the subject/patient is able to read and understand the subject/patient information sheet. 2. prior to any screening procedures, the subject/patient must have signed the informed consent form. no study-related procedures may be performed before the subject/patient has signed the form. 3. age 25-70 years 4. heavy alcohol consumption (males more than 5 doses/ day, female more than 4 doses/day) for at least 10 years 5. alcohol dependence (dsm-iv) assessed by scid-i interview. 6. major depression (dsm-iv) assessed by scid-i interview. at least 4 weeks past from the previous inpatient treatment for aws (alcohol withdrawal syndrome). exclusion criteria: 1. other drug dependence (screened by urine test) 2. other serious mental illness (dsm-iv) 3. hazard of suicide 4. pregnancy 5. serious kidney, hart or thyroid problem 6. the subject/patient, in the opinion of the investigator, is unlikely to comply with the clinical study protocol or is unsuitable for any reason. 7. liver cirrhosis or liver enzymes asat tai alat \>200. 8. the person that met the criteria stated in the finnish law on clinical studies, paragraph 7-10§ (children, pregnant, imamates or mentally handicapped).

Keywords: alcoholism depression efficacy study memantine escitalopram
the effect of cort118335 on olanzapine-induced weight gain

Conditions: Antipsychotic-induced Weight Gain

Summary: this study will investigate if there is any difference in the amount of weight gained by participants taking olanzapine with cort118335 compared with olanzapine with placebo (a dummy test medicine which looks like cort118335 but contains no active medicine). safety and tolerability of cort118335 when taken with olanzapine will also be evaluated.


Eligibility criteria:
inclusion criteria: * body mass index 18.0 to 25.0 kg/m\^2, inclusive * stable body weight as indicated by assessment at screening and pre-dose * able to swallow the size and number of tablets required * provide written informed consent and agree to adhere to study restrictions and contraception requirements. exclusion criteria: * have received any investigational medicine in a clinical research study within the previous 3 months, or cort118335 at any time * employee, or immediate family member of a study site or sponsor employee * have a pregnant partner * history of abuse of any drug or alcohol, or regularly consume more than 21 units alcohol/week * smokers or users of e-cigarettes and nicotine replacement products within the last 6 months * clinically significant abnormal results of clinical laboratory safety tests, electrocardiogram, or measurement of heart rate and blood pressure * history of clinically significant cardiovascular, renal, hepatic, endocrine, metabolic, respiratory, or gastrointestinal disease, neurological or psychiatric disorder * history of jaundice or gallstones or had a cholecystectomy * family history or known risk for narrow angle glaucoma * consumed liquorice or other glycyrrhetic acid derivatives regularly in the past 6 months * any condition that could be aggravated by glucocorticoid and/or mineralocorticoid antagonism (e.g., asthma, any chronic inflammatory condition, postural hypotension/orthostatic symptoms) * presence or history of clinically significant allergy * donation or loss of greater than 400 ml of blood within the previous 3 months * are taking, or have taken, any prescribed or over-the-counter drug within 14 days other than paracetamol or standard dose multivitamins. longer restrictions apply for some medicines. * lactose intolerance. note: other protocol defined inclusion/ exclusion criteria may apply.
sevoflurane, propofol, postoperative pain

Conditions: Healthy Adults; Gynecological Disease

Summary: the impact of anaesthetic method (intravenous vs. inhalational) has been proposed, but not proven in a large-scale study. the researchers aim to provide an investigation that has sufficient power to clarify the potential effect of anaesthetic method on postoperative need of opioids. sevoflurane and propofol will be compared.


Eligibility criteria:
inclusion criteria: * age 18-69 years * gender: female * asa status 1-3 * laparoscopic hysterectomy exclusion criteria: * body mass index over 35 * diabetes mellitus * liver disease * allergies to pharmaceuticals used in the study * present use of opioids

Keywords: pain, postoperative anesthetics, intravenous anesthetics, inhalation otherwise healthy adults undergoing general anesthesia for gynecological disease.
daily tadalafil in diabetic ed patients

Conditions: Erectile Dysfunction Associated With Type 2 Diabetes Mellitus

Summary: this study evaluates the effect of 5 mg daily tadalafil therapy on serum levels of endothelin-1 and e-selectin in diabetic male patients with erectile dysfunction. outcomes will be compared pre- and post-treatment versus healthy controls.


Eligibility criteria:
inclusion criteria: male patients aged between 30 and 60 yearsز diagnosed with diabetes mellitus suffering from erectile dysfunction no history of hypertension or other systemic diseases exclusion criteria: history of pelvic trauma or major pelvic surgery pacientes con hipogonadismo o hiperprolactinemia chronic liver disease or cardiovascular disorders chronic use of central nervous system drugs, anti-androgenic drugs, or tramadol smokers non-vasculogenic erectile dysfunction known allergy to tadalafil

Keywords: tadalafil, endothelin-1, e-selectin, diabetic complications, sexual dysfunction, elisa