Kornimate/medical-research-clean huggingface dataset:
a clinical study of mk0991 (caspofungin) in japanese patients with deep-seated candida or aspergillus infections (0991-062)(completed)

Conditions: Fungal Infection

Summary: the purpose of this study is to investigate the safety and efficacy of mk0991 in patients with deep-seated mycoses.


Eligibility criteria:
inclusion criteria: * japanese patients in whom a causative fungus is detected before treatment with the study drug or patients with strongly suspected deep-seated fungal infection due to candida species (spp.) or aspergillus spp. exclusion criteria: * patients with mycoses other than ones due to candida spp. or aspergillus spp. * patients who will receive other systemic antifungal agents for the first time in screening period.
effects of transcranial direct current stimulation (tdcs) on motor function in schizophrenia patients and individuals at risk for psychotic onset

Conditions: Schizophrenia; Psychosis; Parkinsonism; Dyskinesias

Summary: the purposes of this research are to investigate (1) if schizophrenia patients and at-risk individuals present bradykinesia and dyskinesia and (2) if tdcs improves motor performance in schizophrenia patients and at-risk individuals. the first hypothesis is that both schizophrenia patients and at-risk individuals show bradykinesia and dyskinesia, and the motor symptoms are more severe in the former than the latter. the second hypothesis is that tdcs improves motor performance in schizophrenia patients and at-risk cases.


Eligibility criteria:
inclusion criteria for schizophrenia patients: * a diagnosis of schizophrenia without other psychiatric diseases * having stable psychotic symptoms * a score of 22 or above in hong kong version montreal cognitive assessment * having no neurological diseases and no medical conditions that affect motor performance no exclusion criteria. inclusion criteria for at-risk individuals: * a score of nine or above in the chinese version of the 16-item prodromal questionnaire (cpq-16) * a score of 22 or above in hong kong version montreal cognitive assessment * having no diagnosis of psychiatric diseases * having no neurological diseases and no medical conditions that affect motor performance no exclusion criteria. inclusion criteria for healthy controls: * a score less than nine in cpq-16 * a score of 22 or above in hong kong version montreal cognitive assessment * having no diagnosis of psychiatric diseases * having no neurological diseases and no medical conditions that affect motor performance. no exclusion criteria.
evaluation of the efficacy of different nebulization techniques

Conditions: COPD Exacerbation

Summary: copd is the 3rd most common cause of death in the world, and the most common places of admission in our country with exacerbation of copd are emergency services. β-2 agonists and/or short-acting anticholinergic drugs use is recommended in patients with copd salbutamol is known to cause significant improvement in dyspnea, quality of life and fev1 in patients with copd. various techniques are used to administer drugs, one of which is the nebulization technique and is frequently used in emergency departments. there are limited clinical studies comparing different nebulization techniques, and the aim of this study is to compare the efficacy of vibrating mesh nebulizer versus jet nebulizers in a copd exacerbation patient. patients who applied to the emergency department of sultan abdulhamid han training and research hospital with the complaint of shortness of breath and were diagnosed with copd exacerbation according to the gold guidelines and to be treated with nebulization will be included in the study. patients who agreed to participate in the study will be divided into two groups and assigned sequentially according to the simple randomization schedule. medication will be applied to one group with jet nebulizers (philips respironics) and to the other group with vibrating mesh nebulizer (aerogen ultra). vital signs, ipi, spirometric measurements (fev 1, fvc, fev1 / fvc, fef 50, fef 2575), and dyspnea vas score will be recorded at admission and re-measured after 1hour of treatment . in addition, single dose nebulization time will be measured and patient satisfaction will be measured with a 5-linkert scale. demographic data will be recorded. the measurements will be recorded in the patient file and the groups will be coded so that the researcher evaluating the data will be blinded to the groups. the patient could not be blinded because of the different shape of devices.


Eligibility criteria:
inclusion criteria: * acute exacerbation of copd according to gold guidline, * being over 18 years old, * being able to read and to understand the spoken language and give consent. exclusion criteria: * patients who need nimw or intubation. * covid 19 or suspected patients * cognitive disorders

Keywords: copd nebulizers
topical tranexamic acid and acute blood loss in total knee arthroplasty

Conditions: Acute Blood Loss Anemia; Osteoarthritis, Knee

Summary: this study aims to assess postoperative blood loss and transfusion rates in total knee replacement after one-time administration of topical tranexamic acid.

autologous (donor) blood transfusion is an expensive and common occurrence after total knee replacement. published data puts this rate between 9 and 40% after primary unilateral total knee arthroplasty. there have been many proposed adjunctive measures to decrease intraoperative and postoperative blood loss during such surgery. most of these include thrombin inhibition, so-called "minimally- invasive" techniques or instrumentation, or other adjunctive drugs. hitherto, tranexamic acid, a specific drug that promotes part of the clotting cascade, has been used extensively in multiple areas of surgery with multiple studies evaluating its efficacy in cardiac surgery, spinal procedures, and as a dental swishing solution after tooth extraction. there have been small studies evaluating intravenous tranexamic acid and its effect on total knee replacement, with some promising results. the topical form of ta has been evaluated in only one prospective, randomized clinical trial with a significant decrease in postoperative blood loss and a trend towards decreased autologous blood transfusion rates. this study proposes to further evaluate tranexamic acid as an inexpensive and viable option for use in total knee arthroplasty. the topical form of the drug has been shown to achieve these hemostatic effects without increasing the risk of blood clots after surgery. furthermore, the one aforementioned randomized clinical trial used a variety of postoperative deep vein thrombosis prophylaxis after surgery and introduced a potential confounding variable. a rigorous analysis of the effects of tranexamic acid demand a more standardized approach. such a regimen is practiced at henry ford hospital as all patients on the adult reconstruction service are placed on an identical dose of enoxaparin (a subcutaneous blood thinner) postoperatively for two weeks.

Eligibility criteria:
inclusion criteria: * all adult patients over age eighteen * primary unilateral total knee arthroplasty at henry ford hospital (detroit, michigan, united states) and henry ford west bloomfield hospital (west bloomfield, michigan, united states) exclusion criteria: * patient history of venous thromboembolic disease or coagulopathy * use of anticoagulant medications within 7 days of surgery * history of arterial embolic disease * history of class iii or iv heart failure * renal failure * intraoperative cardiovascular, pulmonary, orthopaedic, or anesthetic complication (mi, intraoperative fracture, vasopressor support, emergent intubation).

Keywords: tranexamic acid blood transfusion total knee arthroplasty
revascularization strategies for stemi; the cmr endpoint study

Conditions: Acute Myocardial Infarction

Summary: revascularization strategies for st elevation myocardial infarction (stemi) study (assist-cmr) will compare the effects of two revascularization strategies \[same sitting multivessel primary pci (ss-pci) and culprit vessel only primary pci (ira-pci)\] on myocardial infarct size (mis) as determined by cardiac magnetic resonance (cmr) imaging in patients presenting with stemi and multivessel disease (mvd).


Eligibility criteria:
inclusion criteria: * high risk st elevation myocardial infarction evidenced by: ≥2 mm st elevation in 2 anterior or lateral leads; or ≥2 mm st elevation in 2 inferior coupled with st depression in 2 contiguous anterior leads for a total st deviation of ≥8 mm; or new left bundle branch block with at least 1 mm concordant st elevation. * multivessel cad as evidenced by ≥1 significant (≥70% by visual assessment or ffr\<0.80 for 50-70% stenosis) stenosis in non-ira. * successful ira-pci with \<10% residual angiographic stenosis and timi iii flow. * written informed consent. exclusion criteria: * age ≤ 18 years. * prior coronary artery bypass graft (cabg) surgery. * administration of thrombolytic therapy. * non-ira stenosis is a chronic total occlusion or located in left main artery. * hemodynamic instability evidenced by bp\<90 mmhg, killip class ≥2, need for inotropes/vasopressors. * known renal insufficiency (estimated gfr \< 50ml/min). * contraindication to cmr.

Keywords: stent, myocardial infarction, coronary intervention
pediatric epilepsy database

Conditions: Epilepsy

Summary: the purpose of this database is to collect information for clinical purposes on all children being treated for seizure disorders.

at some point this information may be used to retrospectively review trends in seizure types, diagnostic evaluation and treatment (medical or surgical). the potential data recorded will be that of standard of care provided to these patients, including age, gender, seizure type/classification, diagnostic procedures (eg. eeg, mri magnetoencephalography {meg}, single photon emission computed tomography {spect}, positron emission tomography {pet}, invasive electrocorticography) and various treatments (medications, diet, or neurosurgical interventions for the treatment of epilepsy). records in the database will have identifiable information (name, date of birth, date of procedure, medical record number), but these identifying data will be removed, and only nonidentifying data will be used in the event of research completed using information from this clinical database.

Eligibility criteria:
inclusion criteria: * none exclusion criteria: * none

Keywords: epilepsy
minimal invasive surgery in total hip arthroplasty patients; strength, functionality and post operative complications

Conditions: Hip Osteoarthritis

Summary: the aim of the present study is to explore the most efficient surgical approach in total hip replacement in short and long term when concerning strength, functionality and postoperative complications. the objective is to register muscular strength, hip joint functionality/mobilisation and complications after total hip arthroplasty (tha) performed by two minimal invasive/incision surgeries (mis) versus the traditionally lateral approach. the primary working hypothesis is that due to a minimal dissection and reduced trauma in the muscles, patients will tolerate early hospital discharge better after mis than after traditional lateral surgery. patients in the mis group will also be more active and maintain muscular strength and hip joint functionality/mobilisation better than patients in the lateral group.

with total hip replacement surgery, the orthopaedic surgeon's aim is not only pain relief for the patient, but also restoration of hip joint biomechanics resulting in a minimal functional deficit and maximal longevity of the implant. it is not exceptional that these patients still experience mild to moderate long-term impairments postoperatively. these impairments include pain, muscle weakness of the hip abductors, contracture of the hip, gait disorders, as well as weakness of hip extensors and flexors. these problems may in turn lead to complications such as joint instability and loosening of the implant. when the lateral surgical approach is used, major concerns after total hip replacement surgery are muscle abductor weakness/atrophy, tendon defects of the gluteus minimus muscle, and unsuccessful reattachment or denervation of the anterior gluteal flap. minimal incision/invasive surgery (mis) is defined as a surgical approach performed through a short skin and muscle incision to avoid injury to muscles and tendons. following minimally invasive approach reduced muscle trauma has been found. moreover clinical outcome improved, as the gluteus medius muscle can be spared more successfully. however, it is debated whether or not the overall results of mis are superior, or even as good as the traditional hip replacement surgery in terms of component placing and time to revision of the prosthesis.

Eligibility criteria:
inclusion criteria: * patients scheduled for tha * diagnosis of primary osteoarthritis as the main cause for elective tha * american society of anesthesiologists (asa) score i, ii, and stable iii exclusion criteria: * musculoskeletal diseases * current heart/pulmonary- or malignant diseases likely to influence the physical testing performance.

Keywords: arthroplasty, total hip replacement, hip surgical procedures, operative surgical procedures, minimally invasive
virtual reality effects on pain during hysteroscopy hysteroscopy: a randomized control trial

Conditions: Pain and Hysteroscopy

Summary: the objective of this study is to compare pain levels in women undergoing office-based hysteroscopies using virtual reality versus control in a randomized control prospective trial.

the primary aim of this study is to see if virtual reality can decrease pain intensity during office hysteroscopies using a 100mm visual analogue scale (vas). a secondary aim will be to monitor heart rate for patients using virtual reality versus the controls during the procedure. another secondary aim will be to time the length of the procedure as it is possible if pain perception is reduced, the procedure can be completed faster. lastly, we would also want to evaluate both patient and surgeon satisfaction of the procedure with or without virtual reality by using a satisfaction questionnaire to assess for patients satisfaction with the procedure, with the vr intervention, perceived realism of vr game, and measure simulator sickness related to the vr game.

Eligibility criteria:
inclusion criteria: inclusion criteria will be women over the age of 18 presenting for office hysteroscopy. exclusion criteria: exclusion criteria included patients with visual or auditory impairment that would interfere with their ability to use the virtual reality set, english language non-fluency, history of opioid dependence/abuse, current narcotic use, or desire for narcotic use during the procedure.
accelerated intermittent theta-burst stimulation ameliorate major depressive disorder by regulating camkii pathway

Conditions: Major Depressive Disorder; Major Depressive Disorder, Recurrent

Summary: major depressive disorder(mdd) is a complex and heterogeneous mental disorder. repeated transcranial magnetic stimulation (rtms), as a non-invasive neuroregulatory technique, has shown a promising function in the treatment of depression. theta-burst transcranial magnetic stimulation (tbs) model significantly shortened the duration of physical therapy treatment, and itbs under the accelerated model (the latter is referred to as aitbs)showed promising therapeutic effect. however, whether aitbs has a better and faster curative effect in the first untreated or recurrent unmedicated mdd patients and the mechanism of its alleviation of depressive symptoms remains unclarified. this project intends to verify changes in camkii levels, camkii molecules and gaba receptors in brain-derived exosomes in normal controls and patients who received sham, aitbs and high-frequency (10hz) stimulation respectively. neuroimaging and tms-eeg were used to pinpoint the target of stimulation and to record the changes of brain waves before and after treatment in real time. to clarify the neurobiological mechanism of aitbs rapidly improving depression, and to provide a new strong evidence for clinical transcranial magnetic stimulation for accurate treatment of mdd patients.


Eligibility criteria:
inclusion criteria: * sign a written informed consent to participate in the trial and receive treatment; * major depressive disorder diagnosis; * hamilton depression scale (hamd - 24) 24 total score 20 points or more; * first episode or recurrence of depression patients, not taking psychiatric drugs; * the han nationality, right-handed; * junior high school or above; exclusion criteria: * other organic mental disorders and mental retardation and other severe mental disorders; * infection, trauma, and autoimmune diseases or other possible interference test evaluation of disease; * alcohol and drug dependence or is being treated for a hormone drugs patients; * craniocerebral injury; * seizure or a family history of epilepsy; * pregnancy and lactation women; * all landowners had a metal and mri contraindications or mri examination revealed abnormal brain structure.

Keywords: major depressive disoerder first episode without medication recurrent unmedicated
physician use of non-english language skills in cancer care

Conditions: Breast Cancer; Colon Cancer; Lung Cancer

Summary: the purpose of this study is to test a method for analyzing interactions between patients and doctors, the roter interaction analysis system (rias). the rias measures the quality of communication between patients and their cancer doctors.


Eligibility criteria:
inclusion criteria: * is a english or spanish-speaking patient * between the ages of 21-80 years old * has a new diagnosis of any type of cancer (diagnosed within the past 4 months), or has a recurrence of either breast, colon or lung cancer (recurrence diagnosed within the past 4 months) * scheduled to have surgery or begin chemotherapy and/or radiation therapy within the next 2 months oncology clinician inclusion: * provides care to lep patients * has md, do, rn, np or pa degree * is between the ages of 21-80 exclusion criteria: * is unable to provide informed consent in either english or spanish

Keywords: communication 15-316 physician use non-english language skills
efficacy of kinesio taping on mutational falsetto

Conditions: Mutational Falsetto; Dysphonia

Summary: this study aimed to assess of efficacy of the kinesio-taping on male patients suffering from mutational falsetto

mutational falsetto is a functional voice disorder involving a failure to transition from the high-pitched voice of childhood to the lower-pitch ed voice of adolescence and adulthood. in the recent years, kinesio taping has begun to be employed for treating dysphonia patients. we hypothesized that, because the kinesio taping relaxes the suprahyoid muscles and pushes the larynx backward, it could also be used as a therapy of mutational falsetto. this study aimed to assess of efficacy of the kinesio taping on male patients suffering from mutational falsetto.

Eligibility criteria:
inclusion criteria: * patients suffered from mutational falsetto * patients who were accept to consent form * patients who have not open wound on neck exclusion criteria: * having mental disorders or major physiatric disorders * cognitive limitations * contact dermatitis * history of smoking * asthma, chronic pulmonary diseases * history of allergic reactions against to medical tape applied * having an other organic vocal disorders * advanced hearing loss * out of bmi\<18.5 or 30\<bmi * out of age 16-60 years old patients who were not accept to consent form.

Keywords: kinesio taping mutational falsetto therapy dysphonia
reducing with metformin vascular adverse lesions in type 1 diabetes (removal)

Conditions: Diabetes Mellitus, Type 1

Summary: the trial is conducted in the united kingdom (uk), australia, canada, denmark and the netherlands. the aim is to test whether 3 years treatment with metformin added to titrated insulin therapy (towards target hba1c 7.0%/53 mmol/mol) reduces atherosclerosis, as measured by progression of carotid intima-media thickness (cimt), in adults with confirmed type 1 diabetes aged 40 years and over at increased risk for cardiovascular disease.


Eligibility criteria:
inclusion criteria: * type 1 diabetes for five years or more\* * age 40 years or above * 7.0 =\< hba1c \<10.0% (53 - 86 mmol/mol) and 3 or more of the following ten cardiovascular disease (cvd) risk factors: * bmi \>27 kg/m\^2 * current hba1c \>8.0% (64 mmol/mol) * known cvd/peripheral vascular disease * current smoker * estimated glomerular filtration rate (egfr) \<90 ml/min per 1.73 m\^3 * confirmed micro- or macroalbuminuria \[according to local assays and reference ranges\] * hypertension (bp \>=140/90 millimeters of mercury (mmhg) or established on antihypertensive treatment) * dyslipidaemia \[total cholesterol \>=5.0 mmol/l (200 mg/dl);or hdl cholesterol \ =1.7 mmol/l (150mg/dl); or established on lipid-lowering treatment)\] * strong family history of cvd (at least one parent, biological aunt/ uncle, or sibling with myocardial infarction or stroke aged \<60 years) * duration of diabetes \> 20 years exclusion criteria: * egfr \< 45 ml/min/1.73m2 * woman of childbearing age not on effective contraception * pregnancy and/or lactation * acute coronary syndrome or stroke/transient ischaemic attack within the last three months * nyha stage 3 or 4 heart failure * significant hypoglycaemia unawareness * impaired cognitive function/ unable to give informed consent * previous carotid surgery/ inability to capture adequate carotid images * estimated glomerular filtration \< 45ml/min/1.73m\^2 (mdrd) * gastroparesis * history of lactic acidosis * other contraindications to metformin (hepatic impairment, known hypersensitivity to metformin, acute illness such as dehydration, severe infection, shock, acute cardiac failure or suspected tissue hypoxia) * any coexistent life threatening condition including prior diagnosis of cancer within two years * history of alcohol problem or drug abuse

Keywords: removal metformin carotid imt ldl cholesterol endothelial function retinopathy hba1c
juvenile postlumbar puncture headache after puncture with needles with quincke tip or with sprotte tip

Conditions: Headache

Summary: the purpose of this study is to compare postlumbar puncture complaints as headache or backache after lumbar puncture with needles with quincke design or with sprotte design in children and adolescents.

after lumbar puncture patients may develop complaints as position dependent headache, other headache or backache. several though not all studies in adults showed that the frequency of complaints can be reduced by using non-traumatic sprotte-design needles instead of cutting quincke-design needles. in children and adolescents there are no comparable data published. in most pediatric hospitals in germany quincke needles are used. comparison: children and adolescents from 4 to 18 years of age who have to undergo a lumbar puncture are randomly attributed to puncture with quincke needle or with sprotte needle. during the following days headache (main criterium), position-dependent headache, backache, vomitus, and malaise are noted. pain is measured with a visual analogue scale/faces scale.

Eligibility criteria:
inclusion criteria: * lumbar puncture necessary for diagnostic reasons exclusion criteria: * intrathecal instillation at lumbar puncture * patients in whom severity of disease make it impossible to judge endpoint criteria

Keywords: postlumbar puncture headache atraumatic needle sprotte quincke lumbar puncture headache backache