Kornimate/medical-research-clean huggingface dataset:
simultaneous corneal wavefront-guided trans-prk and corneal collagen crosslinking after icrs implantation for moderate keratoconus

Conditions: Moderate Keratoconus

Summary: the investigators aim to investigate the effects of combined corneal wavefront-guided transepithelial photorefractive keratectomy (tprk) and accelerated corneal collagen cross-linking (cxl) after intracorneal ring segment (icrs) implantation in patients with moderate keratoconus. medical records of 23 eyes of 23 patients undergoing combined tprk and cxl after icrs implantation were retrospectively analyzed. uncorrected distance visual acuity (udva), corrected distance visual acuity (cdva), manifest refraction spherical equivalent (mrse), corneal indices based on scheimpflug tomography, higher-order aberrations (hoas), and corneal biomechanical properties were evaluated before and after icrs implantation, and at 1, 3, and 6 months after combined tprk and cxl. corneal biomechanical properties were measured using the dynamic scheimpflug analyzer at approximately the same time of day.

the investigators aim to investigate the effects of combined corneal wavefront-guided transepithelial photorefractive keratectomy (tprk) and accelerated corneal collagen cross-linking (cxl) after intracorneal ring segment (icrs) implantation in patients with moderate keratoconus. medical records of 23 eyes of 23 patients undergoing combined tprk and cxl after icrs implantation were retrospectively analyzed. uncorrected distance visual acuity (udva), corrected distance visual acuity (cdva), manifest refraction spherical equivalent (mrse), corneal indices based on scheimpflug tomography, higher-order aberrations (hoas), and corneal biomechanical properties were evaluated before and after icrs implantation, and at 1, 3, and 6 months after combined tprk and cxl. corneal biomechanical properties were measured using the dynamic scheimpflug analyzer at approximately the same time of day. the dynamic scheimpflug analyzer automatically calculated corneal deformation amplitude, radius values, and maximal concave power when the cornea is deformed to its greatest curvature by the air puff. the deformation amplitude is defined as the maximum amplitude when the cornea is deformed to its greatest concave curvature and is influenced by corneal stiffness. the radius values represent the central concave curvature at the highest concavity (depressed to the highest concavity), while maximal concave power is the inverse radius of the curvature at the highest concavity.

Eligibility criteria:
inclusion criteria: * intolerant to contact lenses * moderate keratoconus without apical scarring * if progression had been noted over the previous 6 months * all included patients underwent combined corneal wavefront-guided tprk and cxl at least 1 month (average 2.7 ± 1.1 months; range 1 to 4 months) after icrs implantation. exclusion criteria: * central or para-central corneal scarring * central pachymetry \< 400 microns * corneal endothelial cell density of less than 2000 cells/mm2 * systemic autoimmune disease * a history of herpetic corneal disease * pregnancy * lactation * severe dry eye syndrome
optimized anesthesia to reduce incidence of postoperative delirium

Conditions: Postoperative Delirium

Summary: the purpose of this study is to compare the difference of incidence of postoperative delirium between patients received general anesthesia guided by bispectral index (bis) and patients received general anesthesia using standard technique.

general anesthesia is one of precipitating factor of postoperative delirium which its mechanism is still unknown. general anesthesia can affect on pattern of electroencephalograph. previous studies showed that patients received bis guided anesthesia could wake up faster, earlier extubation and stay in recovery room shorter compared to standard general anesthesia. optimized level of anesthesia by bis could reduce cognitive dysfunction in elderly patients and reduce biological marker of brain injury. therefore, the investigators hypothesized that adjustment of general anesthesia by bis guided could protect central nervous system and reduce incidence of postoperative delirium.

Eligibility criteria:
inclusion criteria: * patients age equal or more than 65 years. * patients undergoing general anesthesia. * patients undergoing scheduled, non-cardiac surgery exclusion criteria: * patients undergoing neurosurgery. * patients cannot understand thai language. * patients who have severe visual or hearing impairment.

Keywords: postoperative delirium
community, home-based education, screening services strategy to increase cervical cancer control access for hiv-positive women in nigeria

Conditions: HIV; Cervical Cancer

Summary: the goal of this observational study is to focus on adapting and implementing a program to promote hpv and cervical cancer (cc) screening and follow-up treatment for hiv-positive women, with three specific aims: * adaptation: use stakeholder deliberation to tailor the successful moment program for this population. * implementation and assessment: deploy the adapted moment program and evaluate its reach, effectiveness, adoption, and fidelity. * evaluation: conduct a post-implementation process evaluation to identify barriers and facilitators to the program's maintenance and sustainability.

despite the increased risk of cervical cancer (cc) among women living with hiv (wlwh), access to cc screening in nigeria remains limited. while advances in prevention programs and antiretroviral therapy have reduced other aids-associated malignancies, cc risk in wlwh persists. this study aims to leverage nigeria's existing hiv treatment infrastructure to integrate home-based cc (hcc) screening for wlwh. the approach involves adapting the moment (mother mentor) peer-based hiv support program to include hcc screening and evaluating its implementation and sustainability using the consolidated framework for implementation research (cfir) and re-aim frameworks. the study has three key aims: * adapting the moment program to promote home-based hpv screening and follow-up treatment through stakeholder deliberation. * implementing and assessing the program's reach, effectiveness, adoption, and fidelity with a sample of 1,500 wlwh. * conducting a post-implementation evaluation to identify barriers and enablers for program maintenance and scalability. stakeholder input, including perspectives from wlwh, peer counselors, clinical managers, and policymakers, will guide the program's design and execution. by integrating stakeholder insights and addressing systemic challenges, the study aims to advance cc control in nigeria and provide a scalable model for implementing cancer control strategies for people living with hiv in low- and middle-income countries globally.

Eligibility criteria:
inclusion criteria: - patients must be able to perform vaginal self-collection as well as give informed consent exclusion criteria: * male gender * age \ 50 * unknown or negative hiv status * pregnancy * hysterectomy * inability to give informed consent inability/refusal to perform vaginal self-collection

Keywords: women living with hiv cervical cancer screening
comparative effects of dexmedetomidine and ketofol for sedation in patients undergoing trans-esophageal echocardiography

Conditions: Heart Valve Disease; Heart Septal Defects, Atrial

Summary: the purpose of the study is to compare dexmedetomidine and ketofol to find a suitable alternative for moderate sedation in out-patient diagnostic trans-esophageal echocardiography.

sample size was estimated based on previous studies with sedation in equally invasive procedures that in 2 groups difference in time to achieve ramsay sedation scale was 0.8min.(in group dexmedetomidine 12.4 \& group ketofol 13.2 with s.d of 0.8). the sample size came out to be 22 subjects per group at a power of 90 % \& confidence interval of 95 %. for possible dropouts, it was decided to include 10% extra subjects so finally it was decided to include 25 subjects per group. (total sample size 50 subjects) normality of quantitative data will be checked by measures of kolmogorov smirnov tests of normality. if data is normally distributed student t-test will be applied for comparison of 2 groups. mann-whitney u-test will be used for statistical analysis of skewed continuous variables or ordered categorical data. proportions will be compared using chi square or fisher's exact test whichever is applicable. wilcoxon signed rank test will be used for skewed data or for scores (time related variables). . for comparison (time related variables) of hemodynamics repeated measure anova will be applied. all statistical tests will be two-sided and will be performed at a significance level of α=0.05. analysis will be conducted using spss for windows

Eligibility criteria:
inclusion criteria: * patients with atrial septal defect/valvular heart disease (ms/mr/as/ar) exclusion criteria: * atrial fibrillation with fast ventricular rate * congestive cardiac failure * bmi \> 30 * perforated viscus/active gi bleed * esophageal stricture/tumor/laceration * h/o radiation to neck \& mediastinum * h/o gi surgery or h/o dysphagia * restriction of neck mobility * active esophagitis/peptic ulcer disease * symptomatic bradycardia * seizure disorder * coagulopathy/thrombocytopenia

Keywords: echocardiography transesophageal dexmedetomidine ketamine propofol
incidence and severity of acute respiratory distress syndrome (ards) in the french wounded soldiers

Conditions: Acute Respiratory Distress Syndrome

Summary: the purpose of this study is to evaluate the incidence of the ards in the french wounded soldiers.

the acute respiratory distress syndrome (ards) complicates war wounds. among the repatriated wounded persons, it can appear in the first 7 days. it has been well described among american soldiers and it is known that it's serious, frequent and multifactorial. however, not a single study has described the frequency and the severity of the ards in french wounded soldiers. thus the purpose of this study is to estimate the incidence and severity of the ards among the french wounded soldiers, admitted in continuing care and intensive care unit between 2001 and 2017. the analysis of this data collection will let us improve the medical care of the ards in outside operation.

Eligibility criteria:
inclusion criteria: * patient evacuated from the theatre of outside operation and hospitalized in intensive care unit in france between 2001 et 2017 exclusion criteria: * opposition to the use of personal data

Keywords: war wounds intensive care unit
carboplatin and paclitaxel with or without cp-751, 871 (an igf-1r inhibitor) for advanced nsclc of squamous, large cell and adenosquamous carcinoma histology

Conditions: Carcinoma, Squamous Cell; Carcinoma, Adenosquamous; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung

Summary: determine whether the addition of cp- 751,871 in combination with paclitaxel plus carboplatin prolongs survival in patients with locally advanced (stage iiib with pleural effusion) or metastatic (stage iv or recurrent) nsclc of non adenocarcinoma histology.

the study was discontinued on december 29, 2009 due to an analysis by an independent data safety monitoring committee indicating that the addition of cp-751,871 \[figitumumab\] to paclitaxel plus carboplatin would be unlikely to meet the primary endpoint of improving overall survival compared to paclitaxel plus carboplatin alone. the dsmc recommendation to terminate the trial was based on futility, not on specific safety concerns; however, the dsmc recommended to investigate hyperglycemia as a potential contributor to the morbidity of the patients.

Eligibility criteria:
inclusion criteria: * confirmed diagnosis of non small cell lung cancer with a primary histology of predominantly squamous cell, large cell or adenosquamous carcinoma. * advanced nsclc with documented stage iiib (with pleural effusion) or stage iv or recurrent disease. * no prior systemic treatment for nsclc, except for adjuvant chemotherapy. adjuvant chemotherapy must have completed for greater than or equal to 12 months prior to randomization. * prior surgery or radiation therapy is permitted if completed at least 3 weeks prior to randomization and all acute toxicities have resolved. * ecog performance status (ps) 0 or 1. exclusion criteria: * patients with symptomatic central nervous system (cns) metastases are not permitted. * patients requiring chronic steroid use or patients with uncontrolled diabetes are not permitted. * patients with other active cancer types are not permitted.

Keywords: igf-1r inhibitor non-small-cell lung carcinoma cp-751 871
st- depression on electrocardiogram during caesarean section in regional anaesthesia in women with preeclampsia

Conditions: Preeclampsia

Summary: the investigators examined whether there was a difference in the occurrence of st depressions after injection of five or ten units of oxytocin, in preeclamptic patients delivered by caesarean section (cs) under regional anesthesia.

st depression on electrocardiograms has been reported in healthy women undergoing cesarean section in regional anesthesia. the investigators examined whether there was a difference in the occurrence of electrocardiogram changes suggestive of myocardial ischemia (st depressions) in preeclamptic patients randomized to five or ten units of oxytocin during cesarean section with regional anesthesia. in a double-blind randomized controlled study preeclamptic patients undergoing cesarean section under spinal anesthesia were randomized to 5 or 10 units of oxytocin, given as an intravenous bolus. a holter monitor was used to record electrocardiograms. non-invasive blood pressure and heart rate were monitored.

Eligibility criteria:
inclusion criteria: * women with preeclampsia undergoing cs under spinal anesthesia. preeclampsia was diagnosed if blood pressure was ≥ 140/90 mm hg and if proteinuria of more than 1000 mg/day persisted. exclusion criteria: * multiple birth, * obesity (body mass index \> 35), * age \< 18 years, * complications of the pregnancy other than preeclampsia or non-proficiency in the swedish language

Keywords: cesarean section electrocardiography heart hypotension ischemia oxytocin preeclampsia regional anesthesia ecg changes suggestive of myocardial ischemia
serum omentin-1 and carotid atherosclerosis in non-diabetic chronic kidney disease

Conditions: Non-diabetic Chronic Kidney Disease; Atherosclerosis

Summary: the aim of the study is to evaluate whether a low level of serum omentin-1 is associated with carotid atherosclerosis and mediated by inflammation.

atherosclerotic cardiovascular disease is markedly increased in chronic kidney disease. there are a lot of risk factor, along with conventional risk factors. serum onemtin-1 is a adipokine and suggested as a new marker for vascular disease.it has some anti-atherogenic properties. studies investigating serum omentin-1 level have usually conducted in patients with diabetes mellitus.

Eligibility criteria:
inclusion criteria: * between ages of 18 - 65 years old chronic kidney disease of stage 3-4 exclusion criteria: * chronic kidney disease of stage 5 * the history of ischemic cardiovascular disease (myocardial infarction, unstable angina, stroke, peripheral artery disease, or cardiovascular revascularization) * severe heart failure * stage 2 hypertension * diabetes mellitus * corticosteroid therapy * severe hepatic disease * smoking * inflammatory disease * acute infectious disease * malignancy

Keywords: omentin-1 carotid atherosclerosis kidney disease
efficacy of hip strengthening on dynamic knee stability, disability and gait in knee osteoarthritis

Conditions: Knee Osteoarthritis

Summary: this study will be conducted to investigate the role of hip strengthening in improving dynamic knee stability, gait parameter, lower extremity strength and disability in knee osteoarthritis

knee osteoarthritis accounts for more than 80% of the total burden of the diseases. patients with knee osteoarthritis had worse spatiotemporal gait parameter and dynamic instabitity. there are significant hip muscle weakness in knee osteoarthritis. hip muscle weakness leads to improper alignment and stress in knee joint. hip muscle strength can affect knee joint loading and disease progression in knee osteoarthritis. muscles of the lower extremity play a critical role in the preservation of normal knee joint function by providing dynamic knee joint stability and shock absorption, while maintaining safe transfer of forces across the joint.

Eligibility criteria:
inclusion criteria: age 40 to 65 years grade 2-3 on kl grade bmi 25 to 32 kg/m2 medial koa exclusion criteria: * lateral koa intraarticular corticosteriod injection into knee within pervious 3 months significant comorbidity individuals with known hip osteoarthritis previous trauma affection one or both hips history of other medical conditions affecting the knee joint previous replacement of any joint in the lower extremity low back pain cognitive impairment
single dose study of the effect of formoterol fumarate in combination with mometasone furoate inhaled via a pressurized metered dose inhaler (pmdi) in children aged 5-11 years old with persistent asthma

Conditions: Asthma

Summary: this study is being conducted to compare the pharmacodynamics (bronchodilation, onset and duration of action), of a single dose of formoterol fumarate in combination with mometasone furoate to placebo in children of 5-11 years with persistent asthma. the study will also assess the bronchodilatory effect of a single dose of formoterol fumarate alone and in combination with mometasone furoate delivered via a pressurized metered dose inhaler (pmdi) to the bronchodilatory effect of formoterol fumarate delivered via a dry powder inhaler (dpi). furthermore, pharmacokinetic assessments of plasma and urine will also be conducted throughout the study to assess systemic exposure following administration of the study medication.


Eligibility criteria:
inclusion criteria: * 5 to 11 years of age of either sex and of any race * a diagnosis (according to the global initiative for asthma \[gina\] guidelines) of persistent asthma for a period of at least 6 months prior to screening and must have been on a stable asthma regimen (daily dose unchanged) for at least 4 weeks prior to screening * β2-agonist reversibility, defined as an increase in absolute fev1 of ≥12% within 30 minutes after administration of 200μg of salbutamol without the use of a spacer or its equivalent in accordance with ats/ers standards * a child must have an fev1 of ≥ 60% and ≤ 90% of polgar predicted when all restricted medications have been withheld for the appropriate intervals exclusion criteria: * use of other investigational drugs at the time of enrolment, or within 30 days or 5 half-lives of enrolment, whichever is longer. * history of malignancy of any organ system within past 5 years. * pre-dose change (increase or decrease) in absolute fev1 of 15% at visit 2, compared with value at screening. * hospitalized or had an emergency room treatment for an acute asthma exacerbation in the 1 month prior to visit 1, or who had a clinical deterioration of asthma between visits 1 and 2 that resulted in emergency treatment, hospitalization, or treatment with excluded asthma medication. * significant medication condition or situation. * qtc \> 440 msec (boys) or \> 450 msec (girls) on electrocardiogram(ecg) assessment at screening. * upper or lower respiratory tract infection within 4 weeks prior to screening. * chronic conditions affecting the respiratory tract or chronic lung diseases.

Keywords: asthma children persistent asthma
fast advanced closed-loop therapy

Conditions: Type 1 Diabetes

Summary: a double-blind, multinational, multicenter, randomised, 2-period crossover study to assess the efficacy and safety of advanced closed-loop insulin delivery with minimed 670g 4.0 system comparing faster insulin aspart to standard insulin aspart therapy over 4 weeks in active children and adolescents with type 1 diabetes.


Eligibility criteria:
inclusion criteria: * age between 10 and 18 years of age * type 1 diabetes for at least 6 months * insulin pump user for at least 3 months * total daily dose of insulin \>8 units/day * treated with rapid acting insulin analogue * subject/carer is willing to perform at least 2 finger-prick blood glucose measurements per day * screening hba1c ≤ 11 % (97 mmol/mol) based on analysis from local laboratory * willing to wear glucose sensor * willing to wear closed loop system 24/7 * the subject is willing to follow study specific instructions * the subject/carer is willing to upload pump and cgm data at regular intervals exclusion criteria: * physical or psychological disease likely to interfere with normal conduct of the study * untreated coeliac disease or thyroid disease * current treatment with drugs known to interfere with glucose metabolism * participation in another interventional clinical investigation * treated with ultra-rapid acting insulin analogue * known or suspected allergy to insulin * carer's lack of reliable telephone facility for contact * subject's severe visual impairment * subject's severe hearing impairment * medically documented allergy towards the adhesive (glue) of plasters or subject is unable to tolerate tape adhesive in the area of sensor placement * serious skin diseases located at places of the body corresponding with sensor insertion sites * sickle cell disease, haemoglobinopathy; or has received red blood cell transfusion or erythropoietin within 3 months prior to time of screening