Kornimate/medical-research-clean huggingface dataset:
sensory integration disorders in patients with ms including disease advancement and relapses in the last year

Conditions: Multiple Sclerosis

Summary: the aim of the study was to assess the occurrence of sensory integration disorders in people with si depending on the stage of the disease and relapses in the last year;analysis of sensory integration disorders in patients with ms and healthy people

141 patients diagnosed with rrsm were enrolled in the study. the control group consisted of 72 healthy people. the sensory integration assessment scale in adults (spd) was used to test sensory integration, and an original questionnaire was carried out containing information on age, gender, frequency of relapses in the last year, and duration of the disease.

Eligibility criteria:
inclusion criteria: * health of a person * aged 30-45 years * without diagnosed disorders of sensory integration and ms exclusion criteria: * diagnosed disorders of sensory integration * diagnosed with ms

Keywords: multiple sclerosis; sensory integration relapses the advancement of the disease
prevention and treatment of hypertension study (paths)

Conditions: Cardiovascular Diseases; Heart Diseases; Hypertension; Vascular Diseases

Summary: to evaluate the long-term effect of reduction of alcohol intake on blood pressure in moderate but non-dependent drinkers with mild hypertension or high normal blood pressure.

background: numerous observational epidemiologic studies have established ethanol intake as one of the most important determinants of blood pressure levels. however, data from intervention studies were very limited. the study was an inter-agency agreement involving the veterans administration and the national institute on alcohol abuse and alcoholism (niaaa). protocol development occurred between october 1988 and june 1989. the protocol was approved by the va cooperative studies evaluation committee in july 1989 and reviewed by a separate data and safety monitoring board in september 1989. design narrative: subjects were randomized to intervention or control groups. intervention aimed to reduce alcohol intake to no more than 14 drinks per week and 50 percent or less of each participant's baseline level. the intervention technique consisted of a cognitive-behavioral program, the intensive phase of which consisted of six counseling sessions over three months. echocardiograms were obtained at baseline and six months after randomization. biochemical markers were used to validate changes in alcohol consumption. the trial included an eighteen-month feasibility phase with six-month follow-up and a 36-month main trial with two years of follow-up. recruitment for the full-scale trial ended in june 1993. final study visits were conducted in september and october 1994. the study completion date listed in this record was obtained from the "end date" entered in the query view report system (qvr).

Eligibility criteria:
men and women with a diastolic blood pressure of 80 to 89 mm hg and alcohol intake of 21 drinks or more per week.
mind diet intervention and cognitive decline

Conditions: Cognitive Decline; Dementia; Alzheimer Disease; Vascular Dementia

Summary: phase iii randomized controlled trial designed to test the effects of a 3-year intervention of the mind diet (mediterranean-dash intervention for neurodegenerative delay) on cognitive decline and brain neurodegeneration among 600 individuals 65+ years without cognitive impairment who are overweight and have suboptimal diets.

mediterranean-dash diet intervention for neurodegenerative delay (mind) is a phase iii randomized controlled trial designed to test the effects of a 3-year intervention of a hybrid of the mediterranean and dash diets, called mind, on cognitive decline among 600 individuals 65+ years without cognitive impairment who are overweight and have suboptimal diets. the proposed mind diet is a hybrid of the mediterranean and dash diets but with selected modifications based on the most compelling evidence in the diet-dementia field. the mind diet has the same basic components of the dash and mediterranean diets, such as emphasis on natural plant-based foods and limited animal and high saturated fat foods, but uniquely specifies green leafy vegetables and berries as well as food component servings that reflect the nutrition-dementia evidence. the trial will employ a parallel group design comparing the effects on cognitive outcomes of the mind intervention diet plus mild caloric restriction for weight loss to the control diet, usual diet with mild caloric restriction for weight loss. biological effects of the mind diet will be assessed by measurement of brain macro- and micro-structural integrity in 300 randomly selected participants. other biochemical markers will be assessed in the entire cohort of 600 participants, including: plasma abeta 42/abeta 40, brain-derived neurotrophic factor (bdnf) and plasma markers of oxidative stress and inflammation. in addition, the trial will examine potential effect mediators and modifiers by a number of cardiovascular risk factors, ad biomarkers, and biological mechanisms. the proposed study has two clinical sites, one in chicago (rush university) and one in boston (harvard university), and centralized laboratories for data coordinating and analyses (brigham \& women's hospital), neuroimaging analyses (rush university), and specialized laboratories for tissue biochemical analyses.

Eligibility criteria:
inclusion criteria: * family history of dementia * bmi \>=25 * suboptimal diet exclusion criteria: * heavy alcohol use * severe illness * cognitively impaired * psychiatric illness
effects of exogenous ketosis on renal function, renal perfusion, and sodium excretory capacity

Conditions: Ketosis; Essential Hypertension

Summary: this is a randomized, placebo-controlled, double-blinded crossover design. nineteen patients with essential hypertension will be randomized to receive either ketone bodies (ke4) or placebo delivered by ketoneaid. after a period of 5-days treatment, effect variables will be measured (experiment day 1). after a washout period of 14 days, the subjects are crossed over to a similar treatment period with the other treatment. the study is terminated by measuring effect variables after the second treatment period (experiment day 2).

background: renewed interest in ketone bodies has emerged, partly driven by the recent success of selective sodium glucose co transporter 2 (sglt-2) inhibition in preventing cardiovascular deaths in patients with diabetes mellitus (dm) and chronic kidney disease (ckd). effects of ketosis are of importance in order to understand the beneficial effects of sglt-2 inhibitors and to account for the full therapeutic potential of this treatment. hypothesis: ketosis decreases 24 hour systolic blood pressure and increases renal blood flow and glomerular filtration rate (gfr). methods: it is a randomized, placebo-controlled double-blinded cross over study. nineteen patients with essential hypertension will be randomized to receive either ketone bodies (ke4) or for 5 days. after a wash out period of at least 14 days, the subjects are crossed over to receive the other treatment. after each treatment period effect variables will be measured including technetium(tc)99m - diethylenetriamine pentaacetate (dtpa) clearance and water based positron emission tomography computed tomography (pet/ct) perspectives: the study has the potential to provide information regarding the therapeutic potential of treatment with ketone bodies and understanding of conditions characterized by ketosis, such as sglt2-inhibitor treatment.

Eligibility criteria:
inclusion criteria: * essential hypertension (treatment with maximum 2 antihypertensive drugs) * egfr \> 60ml/min * bmi \< 35 kg/m2 * urine albumin creatinin ratio (uacr) \< 300mg/g * safe contraception if women in childbearing age exclusion criteria: * diabetes type 1 or 2 * heart failure * pregnancy or breast feeding * liver disease * malignant disease * recent acute myocardial infarction (ami), apoplexia/transient ischemic attack (tia) (within 12 months of inclusion) * daily use of prescription drugs (expect for contraceptives) * alcohol or drug abuse * periodic fasting * routinely intake of ketogenic diet * treatment with immunosuppressants or sglt2-inhibitors

Keywords: natriuresis kidney circulation kidney physiology glomerular filtration rate
pre-operative intranasal oxytocin for enhancing bariatric-induced diabetes remission

Conditions: Obesity; Diabetes; Bariatric Surgery

Summary: this is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin in obese adults with diabetes undergoing bariatric surgery. subjects will be randomized to receive of intranasal oxytocin or placebo (8 units 3 times daily) for 8 weeks prior surgery. study visits include screening to determine eligibility, cgm will be connected before and after oxytocin administration, and 1 year post surgery. blood tests including oral glucose tolerance test will be done and fat samples will be taken during surgery. the investigator's hypothesis is that oxytocin administration prior bariatric surgery can induce diabetes remission in patients with diabetes


Eligibility criteria:
inclusion criteria: * age 18-65 * diabetes mellitus type 2 * hba1c \< or= 9 * bmi \>35 * eligible for bariatric surgery (after a hospital bariatric committee) * advanced diarem\>6 * signed an informed consent - exclusion criteria: * hba1c above 9 * prior bariatric surgery in the past 6 years * secondary diabetes * steroid therapy * uncontrolled hypertension(\>180/100) * arythmia: paroxysmal tachyarythmia or high degree av-block
acupuncture for breast pain

Conditions: Acupuncture; Mastodynia

Summary: this study is conducted to assess the efficacy and safety of acupuncture in moderate to severe cyclic breast pain.


Eligibility criteria:
inclusion criteria: * meeting the diagnosis criteria of cyclic breast pain. * female patients aged between 18 and 55. * relatively regular menstrual cycle. * cyclic breast pain lasting for 3 consecutive menstrual cycles or more. * the score of worst pain ≥5 on numerical rating scale and any level of breast pain lasting 5-21 days during the run-in period of one menstrual cycle. * no previous experience of acupuncture for breast diseases. * willing to use nonhormonal contraceptives if any risk of pregnancy. * volunteer to the trial and signing written informed consent. exclusion criteria: * noncyclic breast pain. * extramammary pain only. * a history of breast cancer or suspicious of malignancy breast disease by examinations. * the breast imaging reporting and data system (bi-rads) category 4-6 in ultrasound or mammography examinations. * combined with mastitis. * breast pain following injury, surgery, hormones, and/or other drugs. * usage of hormones (including hormonal contraceptives) in the past three months. * combined with severe diseases in the cardiac, respiratory, renal, liver, and hematopoietic systems, psychiatric disorder and/or cognitive disorders. * a history of bilateral ovariectomy or premature ovarian failure. * pregnancy, lactation, or wishing to conceive before the end of the trial. * poor adherence.

Keywords: chronic breast pain female
trial of 70% ethanol versus heparin to reduce the rate of central line infections in children with short bowel syndrome

Conditions: Catheter Related Infections; Short Bowel Syndrome

Summary: this study is designed to determine if the use of 70% ethanol lock solution in central lines decreases the rate of central line infections in children with short bowel syndrome. while ethanol locks have been used safely in children, there has been no published research to date that clearly shows it is of definite benefit in this group of patients.


Eligibility criteria:
inclusion criteria: * age \>3 months * intestinal failure patients * silicone catheter for the administration of parenteral nutrition exclusion criteria: * age \< 3 months * weight \< 5 kg * documented allergy to ethanol * evidence of tunnel site infection * patients receiving continuous renal replacement therapy * concomitant use of metronidazole

Keywords: catheter related infections prevention/control anti infective agents catheter related infections prevention
locally invasive nsclc treated with neo-adjuvant stereotactic body radiotherapy and resection

Conditions: Non-Small-Cell Lung Cancer; Carcinoma

Summary: despite improved staging and operative techniques, the rate of incomplete resection (r1) of nsclc has remained significant over the last decades. patients with r1 resection have significantly worse survival compared to those with complete resection (r0). this is a phase i study that investigates the feasibility and safety of delivering stereotactic body radiotherapy (sbrt) to patients with locally invasive nsclc (ct3-4, n0-1) who are at risk for incomplete resection. twenty patients with nsclc will be treated with sbrt followed by surgery and appropriate adjuvant therapy. patients will be divided into groups, of 5 patients each, treated with escalating doses (35, 40, 45 and 50 gy) in 10 daily fractions. the primary outcome is the feasibility i.e. the ability to complete safely sbrt and surgery (within 6 weeks). secondary outcomes include acute and late adverse events, r0/r1/r2 rates and secondary surrogates of feasibility. if successful, this study will lead to further evaluation of pre-operative sbrt in nsclc.


Eligibility criteria:
inclusion criteria: * patients will be included if they are aged 18 years or older, * with biopsy proven nsclc, * clinically staged t3-t4 marginally resectable i.e. deemed at risk to achieve \<r0 resection (such as invasion of critical mediastinal or hilar structures, nodal extra-capsular extension, chest wall, vertebral bodies, compromised bronchial stump margin, based on ct images of the chest). * patients also need to be pathologically staged n0-1 disease, * with an sbrt ctv≤200cm3, based on planning ct images. * ecog status is required to be \<2 within 4 weeks prior to registration and * patients must be deemed medically operable by the surgical team. exclusion criteria: * patients will be excluded if they are deemed medically inoperable by the surgical team * and have a weight loss of ≥10% within 3 months prior to pathological diagnosis. * patients will also have no absolute contraindication to rt such as connective tissue disease, pacemaker-dependent patient with the pacemaker receiving higher than tolerance dose, had no had previous rt to the current region of the study, that would result in overlap of rt fields, * patients must have no plans to receive other local therapy while on study, except at disease progression, * patients have not had other malignancy within 2 years prior to the study (other than non-melanomatous skin cancers)

Keywords: radiosurgery neoadjuvant therapy
high dose versus low dose oxytocin for augmentation of delayed labour in obese women

Conditions: DELAYED LABOUR

Summary: obesity is one of the biggest public health problems of the 21st century as it increases the risk of many co-morbid medical conditions. obesity in pregnancy places women at higher risk of obstetrical complications during pregnancy, delivery and puerperium. obesity is a risk factor for cesarean delivery, failed induction of labor and labor dystocia, and prolonged labor curves especially among women with class iii obesity.


Eligibility criteria:
inclusion criteria: * spontaneous onset of labor. * body mass index ≥ 30 kg/m2. * gestational age ≥ 37 weeks. * singleton pregnancy. * cephalic presentation. * reassuring fetal heart rate monitoring. * inefficient uterine contractions during active labor * women who will accept to participate in the study. exclusion criteria: * non-reassuring fetal assessment at the time of recruitment. * women received cervical ripening agents. * any patients contraindicated for vaginal delivery. * multiple gestations. * malpresentation. * previous cesarean delivery. * patients with cardiac diseases, pre-eclampsia or any other medical disorders. * fetal demise. * intrauterine growth restriction. * estimated fetal weight ≥ 5000 grams. * pre-labor rupture of membranes \> 24 hours.
effects of virtual reality on cerebral palsy

Conditions: Cerebral Palsy

Summary: virtual reality (vr), is one of the most popular approaches to cerebral palsy (cp) rehabilitation and has been used in rehabilitation field for 30 years. vr is provided via a computer or a game console, and players interact with real-like objects . using a vr interface as a rehabilitation tool increases the fun received by the client which, in turn, increases the participation of the client to the rehabilitation sessions. this is a study that focused on long-term effects of virtual reality (vr) intervention on motor skills and activities of daily living (adl) independence of children with cp.


Eligibility criteria:
inclusion criteria: * had to be 7 to 12 years-old, * to be diagnosed with cp, * to get 1 or 2 from gross motor functioning classification system, * to get a score of 1 to 3 from manual ability classification system, * to score at least 23 from mini mental state examination - children edition, * to be able to follow verbal instructions, and * to have the exclusion criteria: * having any surgical operation and/or botulinum toxin injection in last 6 months, * having any visual and hearing diseases that may affect using vr, and * participating in any other rehabilitation programs (such as physiotherapy, speech therapy, psychotherapy etc.), * having ataxic and/or dyskinetic symptoms.
perioperative changes of heart rate variability related to anxiety and depressiveness in patients undergoing general anesthesia

Conditions: Heart Rate Variability; STAI; SDS; General Anesthesia; Anxiety

Summary: preoperative anxiety can be detected via structured and standardised screening by the state - trait anxiety inventory (stai) and self rating depression scale (sds) questionnaire. the investigators evaluate the relation of perioperative anxiety and heart rate variability, also the impact of general anesthesia on the change of heart rate variability.


Eligibility criteria:
inclusion criteria: * hepatocellular carcinoma patients exclusion criteria: * uncontrolled hypertension uncontrolled diabetes mellitus known autonomic nerve dysfunction
baset scoring: a novel simple biometric score and potential tool for diagnosis and grading of obstructive sleep apnea syndrome (osas) patients

Conditions: Obstructive Sleep Apnea

Summary: this study aims to assess the validity of baset scoring as a new potential tool for diagnosis and grading the severity of osas patients and as screening of the risk factors of osas.

the study will be conducted on one hundred twenty-six patients attending to sleep disorders breathing unit, chest department at mansoura university hospital confirmed by polysomnography

Eligibility criteria:
inclusion criteria: * all adult patients after having full night polysomnography. exclusion criteria: * pregnant patients
a study of bonviva (ibandronate) in women with post-menopausal osteoporosis who have received previous bonviva treatment

Conditions: Post-Menopausal Osteoporosis

Summary: this 2-arm study was designed to assess the long-term safety and tolerability of intravenous (iv) treatment with 2 mg or 3 mg bonviva in women with post-menopausal osteoporosis who had previously completed bonviva study bm16550 (diva study; nct00048074). patients received bonviva either 2 mg iv every 2 months, or 3 mg iv every 3 months. patients also received daily supplementation with vitamin d and calcium. the anticipated time on study treatment was 2+ years, and the target sample size was 500+ individuals.


Eligibility criteria:
inclusion criteria: * successful completion of bonviva study bm16550 (nct00048074), with at least 75% compliance * ambulatory exclusion criteria: * patients who completed the bonviva study bm16550 (nct00048074) \>3 months before the planned start date for this study * malignant disease diagnosed since inclusion into previous study * treatment with drugs affecting bone metabolism since inclusion into previous study
intra-peritoneal environmental changes following surgery

Conditions: Tumor Cells and Tumor Markers in Peritoneal Cavity

Summary: the investigators hypothesize that the presence of tumor cells and tumor markers in peritoneal cavity are indicative for peritoneal spread during surgery, and may serve as early markers for systemic and/or intra-peritoneal recurrence of the disease and ultimately improve our understanding of tumor spread and disease recurrence.


Eligibility criteria:
inclusion criteria: * colon and rectal cancer exclusion criteria: * none

Keywords: colon and rectal tumors colon cancer markers
episodic to real-time care in diabetes self-management

Conditions: Diabetes Mellitus, Type II

Summary: this study will use mobile health technologies to provide everyday data to help patients and their care providers better understand illness dynamics and develop adaptive approaches to improve health outcomes in diabetes. specifically, the study will identify strategies to help patients adapt using multiple types of self-generated diabetes-related data and help providers guide patients to better self-manage in real-time, when guidance is needed most.

the investigators will conduct a mixed-methods exploratory designed study and recruit 60 adult patients (age ≥ 18) with type 2 diabetes who will track relevant clinical data over 6 months. participants will be asked to use a wireless glucose monitor, a cellular body scale, and a wrist-worn accelerometer, and respond to short bi-weekly text message-based surveys on medication adherence for 6 months. data generated from the devices will be plotted as trajectories that will allow us to conduct trajectory analyses and identify missing data points and trends leading to attrition, in order to assess the feasibility of having patients engage in this type of self-monitoring for 6 months. a subset of 20 patients will be interviewed via telephone at the end of their 6 month self-monitoring period to discuss their adaptive challenges and successes over the study period. the investigators will present the trajectories of their data during patient interviews using a visual that we will e-mail or postal mail, depending on patient preference. this will facilitate discussion of the challenges participants face in self-management and adaptive practices participants use. following the 6 months of self-monitoring, we will conduct interviews with health care providers in which the investigators will present the data trajectories and explore ways to achieve continual communication and address real-time challenges with diabetes self-management.

Eligibility criteria:
inclusion criteria: * ≥18 years old * able to speak and read english * diagnosed with type 2 diabetes mellitus * told by their primary care provider to monitor their blood sugar daily * owning and using a smart phone * capable of giving informed consent * with no pre-existing severe medical condition(s) that would interfere with study participation (e.g., renal failure, severe orthopedic conditions or joint replacement scheduled within 6 months, paralysis, or cancer) exclusion criteria: * active dementia or psychiatric illness * reside in a nursing home * participating in another self-management study

Keywords: diabetes, mhealth, mobile health technology