Kornimate/medical-research-clean huggingface dataset:
telemedicine for early detection of cytokine release syndrome and neurotoxicity

Conditions: Large B-cell Lymphoma; Diffuse Large B Cell Lymphoma; Primary Mediastinal Large B Cell Lymphoma; High-grade B-cell Lymphoma; Follicular Lymphoma

Summary: the purpose of this research is to replace one of participants' outpatient chimeric antigen receptor t-cell (car-t) therapy follow up visits with a virtual or "telemedicine" visit. the telemedicine visit will use an electronic tablet with a camera and a microphone that allows participants to communicate with their physicians and nurses. participants will be provided with the necessary equipment to complete these visits.

primary objective: to determine feasibility of telemedicine for outpatient cytokine release syndrome and neurotoxicity assessment (how many telemedicine visits successfully completed per patient) secondary objective(s) * to determine how many times a telemedicine visit triggered an action (inpatient admission/ outpatient observation status) * to determine how many patients were detected to have cytokine release syndrome and/or neurotoxicity based on their telemedicine visit

Eligibility criteria:
inclusion criteria: * patients must have histologically confirmed relapsed or refractory large b-cell lymphoma after two or more lines of systemic therapy, including diffuse large b-cell lymphoma (dlbcl) not otherwise specified, primary mediastinal large b-cell lymphoma, high grade b-cell lymphoma, and dlbcl arising from of follicular lymphoma * age ≥ 18 years * ecog or karnofsky performance status of ≤ 2 * patients must have a caregiver(s) with them 24 hours a day for the first 30 days after car-t cell infusion * patients must stay within a 30-minute distance from the cancer center * patients must have access to wifi network or a cellular network * patients and caregiver(s) participating in patient's care must attend the education session for outpatient car-t and demonstrate competency to collect vital signs with equipment provided * must have the ability to understand and the willingness to sign an irb-approved informed consent document (either directly or via a legally authorized representative). exclusion criteria: * patients who have acute lymphoblastic leukemia/lymphoma * patients who have a high tumor burden (\> 10 cm largest mass) have a high risk of crs who will receive car-t as an inpatient * patient or caregiver unable to understand and follow english language * uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

Keywords: relapsed large b-cell lymphoma refractory large b-cell lymphoma
combination with treg levels and cmr to assess the severity and prognosis of reperfusion injury after ppci in stemi patients

Conditions: STEMI - ST Elevation Myocardial Infarction; Reperfusion Injury, Myocardial

Summary: this study aims to determine whether combination with regulatory t cell (treg) levels and cardiac magnetic resonance imaging (cmr) are predictive of the severity of reperfusion injury following myocardial infarction and the prognosis in stemi patients receiving primary percutaneous coronary intervention (ppci).


Eligibility criteria:
inclusion criteria: * confirmed stemi diagnosis * undergoing primary percutaneous coronary intervention (presenting \<12 hours after symptom onset) * patients were able to complete cardiac magnetic resonance imaging (cmr) and speckle tracking imaging echocardiogram (ste) examinations * patients agreed and provided informed consent exclusion criteria: * previous myocardial infarction or revascularization (pci or cabg) * congestive heart failure with lvef\<40% * atrial fibrillation * renal insufficiency (gfr \< 30 ml/min/1.73m\^2) * acute infectious diseases within nearly 3 months * rheumatic immune system diseases * malignant tumors * claustrophobia * contraindicated to cmr * patients do not agree to be included in the study
effects of rocabado's approach versus kraus exercise therapy

Conditions: Temporomandibular Dysfunction

Summary: tmj dysfunction is linked to trauma, joint overloading owing to para-functional behaviors, mechanical stress, and metabolic issues. myofascial pain and dysfunction, functional derangement, and osteoarthrosis are the three most frequent tmj-related disorders. temporomandibular joint disorders are a type of craniofacial problems. they affect the temporomandibular joint, muscles of mastication, and other musculoskeletal tissues. the most common clinical sign and symptoms associated with tmj dysfunction are orofacial pain and clicking. the aim of study will be to compare the effects of rocabado's approach versus kraus therapy on pain and disability in patients with temporomandibular dysfunction.

a randomized clinical trial will be conducted at fmh physiotherapy clinic and boston physiotherapy clinic lahore through consecutive sampling technique on 40 patients which will be allocated using random sampling through opaque sealed enveloped into group a and group b. group a will be treated with rocabado's approach and group b will be treated with kraus exercises. outcome measures tools will be conducted through nprs, tmd disability index, fonseca questionnaire after four weeks. data will be analyzed during spss software version 21. after assessing normality of data by shapiro-wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups.

Eligibility criteria:
inclusion criteria: * male and female between the ages of 30 to 60 years * patients with jaw pain * patients with limited jaw range of motion and associated joint pain * patients with tmj clicking sounds * patients with pain upon muscle and joint palpation exclusion criteria: * diagnosis of ear, nose, and throat medical pathology underlying the tinnitus; * neurological problems that could potentially cause the tinnitus * inability to read, understand, and complete the questionnaires or understand and follow commands (e.g., illiteracy, dementia, or blindness)

Keywords: rocabado's approach kraus exercises disability
secondary prevention of venous thrombo embolism (vte).

Conditions: Thromboembolism

Summary: the general aim of this study is to determine the comparative safety and efficacy of dabigatran etexilate administered orally and warfarin (international normalized ratio (inr) of 2.0-3.0) for the long-term treatment and secondary prevention of symptomatic venous thromboembolism in patients who have been successfully treated with standard doses of an approved anticoagulant for three to twelve months for confirmed acute symptomatic venous thrombo-embolism.


Eligibility criteria:
inclusion criteria: inclusion_criteria * acute symptomatic deep vein thrombosis (dvt) * pulmonary embolism (pe) 3-12 months prior to screening, which has been documented by objective testing exclusion criteria: exclusion_criteria * symptomatic dvt or pe at screening interruption of anticoagulant therapy for 2 or more weeks during the 3-12 months of treatment for the prior vte. * patients who in the investigators judgement are perceived as having an excessive risk of bleeding elevated aspartate aminotransferase (ast) or alanine tranminase (alt) \> 2x uln * severe renal impairment (estimated creatinine clearance \<= 30 ml/min)
clinical study on the treatment of chronic instability of the lateral ankle joint by repairing the anterior talofibular ligament under total arthroscopy

Conditions: Anterior Talofibular Ligament Injury; Ankle Sprains

Summary: this study mainly evaluated the clinical effect of total arthroscopic repair of the anterior talofibular ligament in the treatment of chronic instability of the lateral ankle. for patients with chronic instability of the lateral ankle, a randomized controlled trial was used to compare the curative effect, operation time, surgical complications, postoperative recurrence rate, postoperative recovery time and patients' satisfaction of the total arthroscopic repair of the anterior talofibular ligament surgery and the modified broström surgery.


Eligibility criteria:
inclusion criteria: 1. a history of acute lateral ankle sprain. 2. the patient has chronic instability of the lateral ankle joint, including functional instability or mechanical instability; functional instability refers to the patient's subjective ankle joint looseness or instability; mechanical instability refers to the presence of the ankle joint history of repeated sprains, positive examination of the front drawer test or positive x-ray examination of the stress position (inversion stress, anterior axial stress). 3. the ankle mri suggested the anterior talofibular ligament injury. 4. it is invalid after 3 months of formal conservative treatment. exclusion criteria: 1. co-infection. 2. there was a previous ankle fracture in the affected limb. 3. the affected limb has previously undergone foot and ankle surgery. 4. ankle inverted arthritis or charcot joint disease. 5. suffer from mental illness.
implementing the decision-aid for lupus (ideal strategy)

Conditions: Systemic Lupus Erythematosus

Summary: the study will attempt to put into practice a shared decision making (sdm) strategy, using an individualized, computerized decision- aid (da) for systemic lupus erythematosus (sle).

the proposed study will evaluate methods to implement a shared decision making strategy, using an individualized, computerized decision- aid (da). the investigators will test the effectiveness of this implementation with 3 strategies in 16 clinics. formative evaluation strategies will be used to assess needs at each clinic, with key clinic informants participating in semi-structured interviews. the study will enroll at least 500 patient participants across all 16 sites, who will review the decision aid and be asked a feasibility and acceptability assessment. at the conclusion of the study, key clinic informants, as well as selected patient participants will participate in semi-structured interviews to assess the effectiveness in implementing the da in the clinic setting.

Eligibility criteria:
clinic personnel inclusion criteria: * aim 1: clinic personnel involved in the care of lupus patients * aim 2: clinic personnel involved in the care of lupus patients * aim 3: clinic personnel involved in the care of lupus patients clinic personnel exclusion criteria: * aim 1: none * aim 2: none * aim 3: none patient inclusion criteria: * aim 2: adults with a diagnosis of lupus * aim 3: adults with a diagnosis of lupus patient exclusion criteria: * aim 2: no diagnosis of lupus, not english or spanish speaking, visually impaired, altered mental status * aim 3: no diagnosis of lupus, not english or spanish speaking, visually impaired, altered mental status

Keywords: lupus decision making implementation sle decision-aid decision conflict
multi-antibiotic resistance carriage in gut flora

Conditions: Intestinal Bacteria Flora Disturbance

Summary: prevalence study evaluating the acquisition of carriage of multidrug-resistant gram-negative bacteria (mdrgnb) in the gut flora in volunteers of french armed forces staying from 4 to 6 months outside france.

emergence of mdrgn bacteria is blowing worldwide up leading to therapeutical failure in hospitalized patients with severe infections, as well as in outpatients with community-acquired infections such as uti. variation in prevalence exists across countries and regions. travels outside own country of residence, like france, whatever the duration (short or long)or the reason (professional or leisure), are known risk factors for acquiring and disseminating mdrgn bacteria. digestive carriage of multidrug-resistant enterobacteriaceae could be a source of infection for the host as well as a source of dissemination. qualitative and quantitative gut colonization by mdrgnb is poorly studied in non-hospitalized people who stayed for a few months out of france. the total amount of multidrug-resistant enterobacteriaceae influences the spread of the dissemination. in our knowledge, no clinical study has been carried out to qualify and quantify gut colonization by mdrgnb in volunteers after staying 4-6 months outside country of residence such as france. a specific microbiological method will be evaluated in this study.

Eligibility criteria:
inclusion criteria: * being older than 18 years * have given an informed consent by signing the written consent * being able to give a stool sample * being member of military forces, supported medically by the french military health services (ssa), and to participate outside mission during 4- 6 months exclusion criteria: * participating in another biomedical study during the study * volunteer unable to give informed consent.

Keywords: prevalence mdrgnb acquisition middle stay endemic area
chest physiotherapy in infants between 0 and 12 months old with acute bronchiolitis srv(+)

Conditions: Bronchiolitis, Viral

Summary: the purpose of this research is to determine the effect of prolonged slow expiration techniques, provoked coughing and standard therapy compared to chest wall manual vibration and standard therapy in infants between 0 and 12 months old with confirmed diagnosis of acute bronchiolitis srv (+). the effect will be measured on respiratory insufficiency and use of supplementary oxygen.

bronchiolitis is the main cause of hospital admission for infants under 1 year old in chile. currently, approximately 4800 children are admitted to the hospital during the cold season, affecting the health services' effectiveness. the most frequent causal agent is the respiratory syncytial virus (rsv). to date, there is no specific treatment for this disease and only support measures are recommended. chest physiotherapy is a support measure that improves the mucociliary clearance and reduces obstruction of the airways. a clinical trial on the effect of prolonged slow expiration (pse), chest wall vibrations, and provoked coughing as treatment for bronchiolitis in infants admitted to the hospital found that the subgroup with rsv required oxygen for 10 hours less than the control group. gomes and postiaux (2012) reported a 50% decrease on respiratory distress measured by the wang score when pse and suction were compared to traditional chest physiotherapy techniques in patients with bronchiolitis rsv(+). currently recommendations in chile suggest chest physiotherapy for outpatients with bronchiolitis, but the guideline does not refer to the case of inpatients. it is proposed to carry out a randomized controlled trial in infants under one year old. the active group will receive standard therapy, pse, and provoked coughing, while the control group will receive standard therapy and manual chest wall vibrations. the effectiveness of chest physiotherapy will be measured though a clinical score of respiratory distress, hours using supplementary oxygen, vital signs before and after the intervention in both groups during hospital stay. the main outcome is clinical severity score 48 hours after admission.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of bronchiolitis. * rsv positive in direct immunofluorescence assay. * wang clinical severity score ≥ 4 points. exclusion criteria: * patients with heart or neurological diseases. * previous episodes of wheezing. * chronic conditions such as bronchopulmonary dysplasia, immunodeficiency, or congenital diseases. * need of mechanical ventilation in intensive care unit * contraindication criteria for chest physiotherapy (i.e. pneumothorax, ribs fractures, hemodynamic instability). * patients not receiving supplementary oxygen.

Keywords: acute viral bronchiolitis respiratory syncytial virus chest physiotherapy
a study of arc1905 (anti-c5 aptamer) in subjects with dry age-related macular degeneration

Conditions: Dry Age-Related Macular Degeneration

Summary: the objectives of this study are to evaluate the safety and tolerability of arc1905 intravitreous injection in subjects with geographic atrophy secondary to dry age-related macular degeneration (amd).


Eligibility criteria:
inclusion criteria: dry amd (drusen and/or geographic atrophy) in both eyes exclusion criteria: * any intraocular surgery or thermal laser within three (3) months of trial entry. any prior thermal laser in the macular region, regardless of indication. any ocular or periocular infection (including blepharitis), or ocular surface inflammation in the past twelve (12) weeks. history of any of the following procedures: posterior vitrectomy, filtering surgery (e.g. trabeculectomy), glaucoma drainage device, corneal transplant or retinal detachment. any of the following underlying diseases including: * diabetic retinopathy * history or evidence of severe cardiac disease (e.g., nyha functional class iii or iv ), history or clinical evidence of unstable angina, acute coronary syndrome, myocardial infarction or revascularization within last 6 months, ventricular tachyarrythmias requiring ongoing treatment. * history or evidence of clinically significant peripheral vascular disease, such as intermittent claudication or prior amputation. * clinically significant impaired renal (serum creatinine \>2.5 mg/dl or status post renal transplant or receiving dialysis) or hepatic function. subjects with results outside these ranges may be enrolled in consultation with ophthotech. * stroke (within 12 months of trial entry). * any major surgical procedure within one month of trial entry. previous therapeutic radiation in the region of the study eye. any treatment with an investigational agent in the past 60 days for any condition. women who are pregnant or nursing. known serious allergies to the fluorescein dye used in angiography or to the components of the arc1905 formulation.

Keywords: amd
development of effective, opioid sparing techniques for peri-operative pain management of transgender patients undergoing gender affirming surgeries

Conditions: Gender Dysphoria

Summary: this study will compare the current standard-of-care pain treatment regimen options that are available to patients who undergo gender-affirming surgery. the purpose of this research is to determine if any of these options are more (versus less) effective than the others to manage surgery related pain, after surgery.


Eligibility criteria:
inclusion criteria: * transgender persons 18 years and older * undergoing gender affirming surgeries performed by either dr. maurice garcia (orchiectomy only, vaginoplasty with or without canal \& orchiectomy, colon-vaginoplasty, \& peritoneal vaginoplasty; stage i phalloplasty, or stage ii phalloplasty); dr. edward ray (feminizing chest surgery, masculinizing chest surgery, stage i phalloplasty); dr. amit gupta (orchiectomy and peritoneal vaginoplasty only); or dr. yosef nasseri (colon vaginoplasty surgery) exclusion criteria: * patients who do not meet the inclusion criteria above * any contraindications to the study drugs. * patients with neurologic deficits that preclude them from sensing pain. * patients with implanted pain neuromodulator devices (e.g., neurostimulator) * patients who do not speak english

Keywords: gender dysphoria gender-affirming surgery peri-operative pain pain management surgery pain sex reassignment surgery gender reassignment surgery vaginoplasty phalloplasty quality improvement opioid use
effect of pilates and kegel exercises during pregnancy

Conditions: Pregnancy

Summary: urinary incontinence and fecal incontinence are common health problems in the postpartum period because of their effect on daily life and are likely to reduce quality of life. it is known that the most effective way to protect from ui during pregnancy and the postpartum period is pelvic floor muscle exercise. this study aimed to investigate the effects of pilates and kegel exercises applied during pregnancy on the quality of life of urinary and fecal incontinence in the postpartum period.

in this study; the effects of pilates and kegel exercises on urinary and fecal incontinence of pregnant women in the 1st and 3rd months postpartum are investigated and which of the applied pilates and kegel exercises is more effective on urinary and fecal quality of life.67 pregnant women with a mean age of 27.29±3.27 years participated in the study. pilates exercise group (peg, n=24), kegel exercise group (keg, n=22), and control group (cg, n=21) were formed with the purposeful method. peg exercise programs were applied for 8 weeks, 2 days a week, 40 minutes, and keg for 8 weeks, 4 days a week, 3 sessions per day. the groups were applied the international incontinence questionnaire short form, urinary incontinence quality of life scale, wexner continence assessment scale, and fecal incontinence quality of life scale at 1st. and 3rd. months postpartum

Eligibility criteria:
inclucision criteria * being between the ages of 18-38 years, * not having a condition that prevents exercise, * being in the 3rd trimester of pregnancy, * voluntarily accepting to participate in the study, a * answering each of the scale items, * having a vaginal (normal) birth. exclusion criteria: * not being between the ages of 18-38, * having a condition that prevents exercise, * not being in the 1st and 2nd trimesters of pregnancy, * leaving scale items blank, and having a cesarean section.

Keywords: urinary i̇ncontinence fecal i̇ncontiance quality of life pregnancy exercise
brentuximab vedotin in patients with cd30-positive nonlymphomatous malignancies

Conditions: Acute Lymphoid Leukemia; Acute Myeloid Leukemia; Anemia, Refractory, With Excess of Blasts; Solid Tumors

Summary: this is an open-label, multicenter, phase 2 clinical trial to evaluate the antitumor activity of brentuximab vedotin as a single agent in patients with cd30-positive nonlymphomatous malignancies.


Eligibility criteria:
inclusion criteria: * histologically-confirmed by central review cd30-positive nonlymphomatous malignancy * have failed, refused, or have been deemed ineligible for standard therapy * measurable disease * eastern cooperative oncology group (ecog) performance status score of 0 or 1 or a karnofsky or lansky performance status score greater than or equal to 70 exclusion criteria: * primary diagnosis of lymphoma or central nervous system (cns) malignancy * history of another primary invasive malignancy that has not been definitively treated or in remission for at least 3 years * evidence of active cerebral/meningeal disease

Keywords: acute lymphoid leukemia myelodysplastic syndrome acute myeloid leukemia solid tumors anemia, refractory, with excess of blasts antibodies, monoclonal antibody-drug conjugate antigens, cd30 drug therapy hematologic diseases immunotherapy monomethyl auristatin e