Kornimate/medical-research-clean huggingface dataset:
impact of health education on school children

Conditions: Intestinal Helminthiasis

Summary: there is a sever lack in application of health education intervention for soil transmitted disease (sth) in rural communities and in school children among orang asli in pahang in malaysia, and also there is a lack of information on the effect of different health education aspects on sth control in malaysia, so the investigators think that introducing such new national educational package and for the first time in malaysian's school will help children to make some behavior changes specially for the school children aiming to use these children as an educator agents to their families and preschool brothers and sisters, to build a base for this issue and to reduce sth intensity in these rural areas, which in turn will determine the best approach to health education intervention to be applied to other rural areas in malaysia.

the world health organization established that infections with sth among school¬children cause malnutrition, intellectual retardation and cognitive and educational deficits. although school-based intervention specifically the deworming antihelminths drugs programme were introduced into school but still orang asli villages in malaysia having a high intensity and higher prevalence rate for sth, therefore the objective of this article was to review other intervention means mainly the health education intervention into school children and rural community, where most of these studies concluded that health education intervention was successful in increasing knowledge and changing some of practices among people and children which in turn decreases the prevalence and intensity of the sth. also we think applying such intervention in malaysia would be a benefit to change knowledge and attitude towards sth, and it will be the first research study to be applied in this field.

Eligibility criteria:
inclusion criteria: * age:7-14 * no evidence of concomitant chronic illness such as acute respiratory tract infections, mental retardation. exclusion criteria: * age over 15

Keywords: health education soil-transmitted helminthiasis ascaris trichuris hookworm prevention and control
prevalence of sexual addiction in an inmate population at the muret detention center in haute-garonne (pas-cd)

Conditions: Sexual Addiction

Summary: sexual addiction, also known as hypersexuality or compulsive sexuality, is a human sexual behavior that results in a continuous and persistent search for sexual pleasure. replacing the former terms satyriasis and nymphomania, the world health organization (who) icd-11 has referred to this disorder as "compulsive sexual behavior disorders". from multiple causes (iatrogeny, neurological causes, psychiatric causes, psychopathological hypotheses), but still only partially known, the inclusion of this disorder among impulsivity-related disorders, obsessive-compulsive disorders or addiction-related disorders is still debated in the scientific literature. thus, in the absence of sufficient robust scientific data, dsm-5 refused to include this disorder in its classification. however, the consequences of this disorder on the psychosocial functioning of individuals are not negligible, which can go as far as the precipitation of a transition to an heteroaggressive act which can thus lead to incarceration. the prevalence of this disorder in the general population is estimated between 2 and 6% based on current literature data. this rate appears to be higher among men and more specifically among sex offenders. however, some authors have noted that the difficulty in determining a clear prevalence of sexual addiction may be related to the still poorly defined diagnostic criteria for this disorder as well as the choice of measurement tools. in the inmate population, to our knowledge, there are no french prevalence studies of this disorder. in addition, no studies have been conducted to compare the prevalence of sexual addiction among sex offenders (saso) with that among non-sex offenders (sanso). we hope that better screening for addiction would enable better management of patients with this disorder, promoting their psychosocial rehabilitation and well-being, so as to prevent the recurrence of a transition to sexual arousal.

this study is intended to assess the prevalence of sexual addiction among a population of detainees at the muret detention center in haute-garonne.

Eligibility criteria:
inclusion criteria: * male subjects * detainees at muret detention center * aged between 18 and 65 at the time of the search * and having agreed to participate in the research. exclusion criteria: * person under legal protection, guardianship or curatorship ; * insufficient command of the french language * existence of cognitive disorders preventing a good understanding of the information relating to the study or the various questionnaires.
limb injuries and post injury rehabilitation trials - tibial shaft fracture

Conditions: Tibia Fracture

Summary: aim of our study is to compare immediate full weight-bearing and partial weight-bearing for 6 weeks after a tibial shaft fracture treated with intramedullary nailing. co-primary outcome is return to work and physical component scale in the sf-36 questionnaire.


Eligibility criteria:
inclusion criteria: * ao/ota 42-a/b acute, noncomminuted diaphyseal fracture of the tibia treated with intramedullary nailing with or without posterior malleolus screw fixation * operated within 72 hours of admittance * age between 18-65 years exclusion criteria: * the inability to fill out the finnish versions of the questionnaires * previous arthroplasty of the knee or the ankle of the fractured limb * previous ipsilateral below-knee fracture requiring surgical treatment or ankle arthrodesis * inability to co-operate * not living independently (institutionalized living before fracture) * open fracture (gustilo grade 2 or over) * pathologic or stress fracture * multiple fractures requiring operative treatment in polytrauma patient * severe medical comorbidity impairing daily activities (inability to go climb three floors without assistance and stopping) * body mass index over 40 * unacceptably high risk of surgery due to severe medical comorbidities * severe substance abuse * patient is retired * age is less than 18 or more than 65 * patient required a fasciotomy due to acute compartment syndrome during or after index surgery * inability to walk before fracture or a daily need of walking aid, such as crutches

Keywords: intramedullary nail weight-bearing
effect of ranolazine on gastrointestinal motor function and pain in patients with ibs-d

Conditions: Diarrhea Predominant Irritable Bowel Syndrome

Summary: will ranolazine improve bowel function and abdominal pain in human subjects with ibs-d?

this is a randomized double-blind placebo-controlled pilot study that will use validated bowel questionnaires to evaluate the effects of ranolazine administered orally twice daily in patients with diarrhea predominant ibs (ibs-d). the study will consist of a 2 week run in period, followed by 4 weeks of treatment period with oral ranolazine 1000 mg twice daily. primary endpoint of the study will be the average bowel symptom scale (bss) scores for diarrhea and adequate relief of ibs pain and discomfort are secondary end points.

Eligibility criteria:
inclusion criteria * males and non-pregnant, non-breastfeeding females with established diagnosis of ibs-d by modified rome iii criteria (abdominal pain intensity: weekly average of worst daily score of \>3.0 on a 0 to 10 point scale and stool consistency: at least one stool with a consistency of type 5, 6 or 7 bristol stool score on at least 2 days per week) * 18-70 years old * u.s. resident * english-speaking (to provide consent and complete questionnaires) exclusion criteria * structural or metabolic diseases/conditions that affect the gastrointestinal system * unable to withdraw the following medications 48 hours prior to the study: * drugs that alter gi transit including lomotil, and bile acid binders such as cholestyramine, prokinetics (e.g. metoclopramide, cisapride and erythromycin), narcotics (e.g. oxycodone, morphine) and anticholinergics (dicyclomine, hyoscyamine). * analgesic drugs including narcotics, nsaid, cyclooxygenase-2 ( cox2) inhibitors (celecoxib, rofecoxib, and valdecoxib) * gabaergic agents (baclofen) * benzodiazepines (e.g. lorazepam, alprazolam, and diazepam). low stable doses of thyroid replacement, estrogen replacement, and low dose aspirin for cardioprotection and birth control pills or depot injections are permissible. * unable to withdraw the following medications, which are contraindications of ranolazine: * strong cytochrome p450, family 3, subfamily a (cyp3a) inhibitors (e.g. ketoconazole, clarithromycin, and nelfinavir) * cyp3a inducers (e.g. rifampin, phenobarbital, st. john's wort) * female subjects who are pregnant or breastfeeding. * current symptoms of severe depression, as measured by hospital anxiety and depression scale ( hads) score greater than 15. * clinical evidence (including physical exam, ecg, laboratory studies and review of the medical history) of significant cardiovascular, respiratory, renal, hepatic, gastrointestinal, hematological, neurological, psychiatric, or other disease that interfere with the objectives of the study. * the corrected qt interval (qtc) \> 490 msec. * active alcoholics not in remission or known substance abusers. * liver cirrhosis * patients with clinically significant hepatic disease. * major cardiovascular events in the last 6 months. * participation in another clinical trial (within 30 days). * incarcerated.

Keywords: ibs-d
pet-mri for axillary staging in node negative breast cancer patients

Conditions: Breast Cancer; Breast Neoplasms; Breast Diseases

Summary: axillary lymph node status is an important prognostic factor for patients with breast cancer. after breast cancer diagnosis, current nodal staging consists of axillary ultrasound (us) combined with tissue sampling when deemed necessary. in case of positive axillary lymph nodes, patients will undergo axillary lymph node dissection (alnd). in case of no suspicious axillary lymph nodes (i.e. clinically node negative patients), patients will undergo sentinel lymph node biopsy (slnb). this surgical nodal staging is accompanied by co-morbidity. in theory, if non-invasive imaging can evaluate the lymph node status accurately, a node negative patient would no longer have to undergo axillary surgery. since mri is suitable for soft tissue imaging and pet has the advantage of showing increased metabolic uptake in lymph node metastases, a combination of these techniques in hybrid pet/mri would be highly desirable. if dedicated axillary hybrid pet/mri is equally accurate to slnb for the detection of negative axillary lymph nodes, work-up could be more efficient by bypassing slnb. however, the accuracy of dedicated axillary hybrid pet/mri needs to be compared with the pathological outcome of slnb (gold standard) first.


Eligibility criteria:
inclusion criteria: 1. female patient with histologically confirmed breast cancer and clinically confirmed negative lymph nodes in the axilla, scheduled to undergo slnb 2. patients who are willing and able to undergo the study procedures 3. the patient has provided personally written informed consent exclusion criteria: 1. patients treated with neoadjuvant systemic therapy prior to axillary nodal staging 2. patients with clinically positive axillary lymph nodes 3. age \< 18 years 4. inability to provide informed consent 5. pregnancy 6. weight \>100 kg (because of the format of the pet/mri scanner) 7. general contraindications for mri (such as pacemaker, aneurysm clips, metallic device in their body, severe claustrophobia) or pet (i.e. known allergy to 18f-fdg) 8. hyperglycaemia (\> 11 mmol/l) at the time of 18f-fdg injection
effects of dietary nitrate supplementation on cardiorespiratory control in chronic heart failure

Conditions: Heart Failure, Systolic

Summary: the main purpose of this study is to determine whether dietary nitrate supplementation via concentrated beetroot juice improves central and peripheral cardiovascular control and physical capacity in patients with systolic heart failure.

chronic heart failure (chf) is a leading cause of morbidity and mortality worldwide. although affecting the heart at first, it is now recognized that disability is largely due to impaired cerebral and skeletal muscle blood flow and consequently microvascular oxygenation. reduced muscle oxygenation compromises oxidative metabolism and thus contractile performance. impaired cerebral oxygenation not only reduces motor output (thus exacerbating muscle fatigue) but also constitutes a predictor of cerebral ischemic events and an independent prognostic risk factor. reduced levels of the vasodilator nitric oxide (no) contribute to impaired blood flow and oxygenation in chf. development of new effective therapeutic strategies is therefore crucial given that current pharmacological treatment has failed to abrogate oxygenation deficits in chf patients. emerging evidence shows that nitrate serves as an alternative source for no and improves muscle blood flow and oxygenation in health. another striking feature of nitrate is that it can improve muscle work efficiency, a tenet of physiology that was once considered immutable. objective: to investigate systematically the role of dietary nitrate supplementation on central and peripheral cardiovascular function in chf patients.

Eligibility criteria:
inclusion criteria: - previous diagnosis of systolic heart failure (left ventricular ejection fraction \<40%) under optimized clinical treatment as judged by the accompanying physician. exclusion criteria: * hospital admission in the previous 6 weeks; * exercise training program in the previous 6 months; * nitrate therapy (e.g., isosorbide dinitrate); * tabagism; * any condition that could interfere with the ability to exercise; * diagnosed psychiatric or cognitive disorders; * type i insulin-dependent diabetes mellitus; * excessively over-weight (bmi\>35kg/m²); * other diagnosed cardiorespiratory disorders (e.g., chronic obstructive pulmonary disease, peripheral artery disease).
clinical study to evaluate the short time efficacy of ap green tea extract affer high fat, high carbohydrate diet

Conditions: Blood Glucose, High

Summary: the objective of this clinical trial is to evaluate the short term effects of single dose ap green tea extracts in subjects with bmi (\ 100 mg/dl after high-fat/high-carbohydrate meal.


Eligibility criteria:
inclusion criteria: * subjects aged 19 years or over * bmi \< 30 kg/m2 * fasting glucose level \> 100 mg/dl (who is not under medication) * subjects who voluntarily decide to participate in this clinical study and sign the informed consent form on their own or through their representatives exclusion criteria: * at the screening visit, subjects who were diagnosed with obesity, diabetes, dyslipidemia and undergoing medication * subjects who were diagnosed with ventricular associated disease, unstable and uncontrolled chronic medical disease, hyper/hypothyroidism, or active malignant tumor and undergoing medication within 4 weeks prior to the first administration of the investigational product * subjects who have renal failure, acute or chronic hepatitis or known liver cirrhosis * in addition to the above, subjects who are determined to be ineligible to participate in the clinical study according to the investigator's medical opinion
concomitant chemo-radiotherapy plus vidl chemotherapy in nk/t-cell lymphoma

Conditions: NK/T-cell Lymphoma of Nasal Cavity

Summary: this study is to evaluate the efficacy of risk-adapted treatment strategy for stage i/ii extranodal nk/t cell lymphoma. the risk stratification is based on the korean nk prognostic index. thus, the group i/ii will receive concomitant chemoradiation followed by vidl chemotherapy. the group iii/iv will receive high dose-chemotherapy followed by autologous stem cell transplantation after the completion of vidl chemotherapy.

1. concomitant chemo-radiotherapy: radiotherapy 36-44 gy/18-22 fractions + weekly cisplatin 30 mg/m2 for 4 weeks 2. rest period: 3 weeks 3. vidl combination chemotherapy: (total 2 cycles) vp-16 (etoposide) 100mg/m2 i.v. d1-3 ifosfamide 1.2g/m2 i.v. d1-3 dexamethasone 40mg/day d1-3 l-asparaginase 4000iu/m2 im d8, 10, 12, 14, 16, 18, 20 repeated every 28 days 4. peripheral blood stem cell mobilization g-csf 400ug/m2/day or 10ug/kg/day s.c. or i.v. for 4-6 days followed by stem cell collection (minimum requirement of cd34+ cells \> 2×106/kg) 5. high-dose chemotherapy with autologous stem cell transplantation busulfex 3.2mg/kg/day from day -7 to day -5 etoposide 400mg/m2/day on day -5, -4 cyclophosphamide 50mg/kg/day on day -3, -2 followed by stem cell infusion

Eligibility criteria:
inclusion criteria: * patients were required to have a biopsy-proven diagnosis of nasal enktl * at least 18 years old * ann arbor stage ie or iie * measurable disease * eastern cooperative oncology group (ecog) performance status of 0-2 * life expectancy greater than 12 weeks * adequate hematologic (hemoglobin \> 9.0 g/dl, absolute neutrophil count \> 1,500/ul and platelets \> 100,000/ul) * renal (serum creatinine \ 50 ml/min) * hepatic (total bilirubin \< 2 times of upper limit of normal and aspartate transferase \< 3 times of upper limit of normal) function * diagnosis of enktl is based on the presence of histological features and immunophenotypes compatible with enktl (e.g., cytoplasmic cd3+, cd20-, cd56+, positive for cytotoxic molecules, positive for ebv by in situ hybridization). * informed consent exclusion criteria: * prior or concomitant malignant tumors * any coexisting medical problems of sufficient severity to prevent full compliance with the study protocol. * enktl with non-nasal sites such as skin or gastrointestinal tract was excluded even if it is localized. * other subtypes of non-hodgkin lymphoma (nhl), including myeloid/nk cell precursor acute leukemia, blastic nk cell lymphoma/precursor nk cell lymphoblastic leukemia, aggressive nk cell leukemia, and peripheral t cell lymphoma, unspecified, were excluded.

Keywords: extranodal lymphoma natural killer cell t cell radiotherapy chemotherapy
comparing water immersion and water exchange methods during minimally sedated colonoscopy

Conditions: Colon Neoplasm; Pain

Summary: in minimally sedated asian patients in a community setting the investigators showed that a limited volume of water infusion instead of air insufflation in either the rectal sigmoid colon or the whole colon significantly reduced pain score during colonoscopy. cecal intubation rate was not compromised. the reduction of pain score ranges from 25% to 32 % in our previous studies.1, 2 in contrast, several us reports described the successful use larger volumes of water infused throughout the entire colon in patients undergoing colonoscopy which result in a greater reduction of the pain score, averaging about 56%.3-5 a recent review suggested that the cause of the difference might lies in the timing of water removal.6 specifically, the investigators group removed the infused water predominantly during withdrawal phase (water immersion) and the u.s. group removed water during insertion phase (water exchange). this prospective, randomized controlled trial compared water exchange or water immersion with traditional air insufflation in patients undergoing minimally sedated colonoscopy. the investigators test the hypothesis that water exchange can reduce more pain than water immersion in the investigators clinical setting.

all procedures will be recorded and stored as digital files.

Eligibility criteria:
inclusion criteria: * patients undergoing minimally sedated colonoscopy exclusion criteria: * obstructive lesions of the colon, inadequate bowel preparation, allergy to meperidine, massive ascites, past history of partial colectomy, or refusal to provide written informed consent.

Keywords: colonoscopy
perioperative intervention to improve post-tkr support and function

Conditions: Osteoarthritis; Arthroplasty, Replacement, Knee

Summary: knee osteoarthritis is one of the most common causes of disability in older adults. total knee replacement (trk) surgery is often an effective solution when persistent pain does not sufficiently improve with non-surgical treatment. although most tkr surgeries are a success, an estimated 15% to 30% of patients report no clinically significant improvement in function 12 months after a tkr. this study will evaluate the effectiveness of a patient support program in increasing physical function after a tkr surgery.

each year, more than 350,000 adults elect to have tkr surgery to eliminate knee pain and associated disabilities that persist despite ample medical treatment. common knee problems of people who undergo tkr surgery include osteoarthritis, rheumatic diseases, and sudden or gradual joint injury. most people who undergo tkr surgery experience immediate and significant decrease in pain, improved joint function, and increased physical activity. however, not all people who undergo tkr surgery report improvement, and there is no one factor that contributes to this variation in functional gain. with the rapid growth in the number of people electing to have tkr surgery and in the number of candidates eligible for tkr, optimal surgical results are both a clinical and public health priority. this study will evaluate the effectiveness of a patient support program emphasizing exercise and emotional health in increasing physical function after tkr surgery. participants in this study will be randomly assigned to a tkr patient support program or treatment as usual. the intervention patients will receive a program designed to complement the intensive physical rehabilitation period. sessions will aim to help participants enhance their self-management skills for behavior change.

Eligibility criteria:
inclusion criteria: * scheduled for tkr surgery with one of university of massachusetts memorial health center's surgeons prior to study entry exclusion criteria: * tkr due to fracture, malignancy, infection, or failure of a previous knee replacement surgery * inability to return home during the rehabilitation period * co-existing conditions that would negate functional improvement with surgery and exercise * tkr surgery scheduled on an emergency basis * scheduled for tkr surgeries of both knees at the same time * terminal illness with a life expectancy of less than 1 year * inability to provide informed consent due to dementia or cognitive impairment * planning another tkr or thr surgery within 6 months of study entry * unavailable to complete study procedures (i.e., will be out of the region during the rehabilitation period)

Keywords: physical function total knee replacement physical activity behavioral support arthroplasty function self-care