Kornimate/medical-research-clean huggingface dataset:
efficacy of igm rich immunoglobulin with antibiotics for bacterial sepsis in very low birth weight preterm neonates

Conditions: Neonatal SEPSIS; Very Low Birth Weight Baby

Summary: study comprises of giving ivig to half of the septic vlbw preterm neonates along with ongoing antibiotics and placebo to the other half. the immunoglobulin will be given for 3 days and neonates will be monitored for the results. the data will be analysed on the basis of blood culture results and outcome of the patients.


Eligibility criteria:
inclusion criteria: * preterm * very low birth weight baby: birth weight 1-1.5 kg * both inside and outside delivered babies * gender: males and females * probable severe sepsis (septic score) exclusion criteria: * extremely low birth weight babies: \< 1 kg * babies \>1.5 kg birth weight * babies born with congenital malformations * full term babies * iugr babies * child with no signs of sepsis * hbsag positive * hiv positive

Keywords: igm immunoglobulin neonatal sepsis very low birth weight preterm
variability in thermal thresholds in patients with persistent pain after open inguinal herniotomy

Conditions: Persistent Pain After Open Inguinal Herniotomy

Summary: the study will investigate the test-retest variability of thermal thresholds in patients with persistent pain after open inguinal herniotomy. sensory mapping with a cool metal roller delineated an area with cool sensory dysfunction on the painful site. in this area and in a contralateral area as a control, 5 sites were outlined, including the point of maximum pain. in these total 10 sites warmth detection threshold (wdt), cool detection threshold (cdt) and heat pain threshold (hpt) were assessed using quantitative sensory testing. tests were repeated after a 4-6 weeks interval.


Eligibility criteria:
inclusion criteria: * patients with persistent pain after open inguinal herniotomy * age \> 18 years exclusion criteria: * cognitive impairment * drug or alcohol abuse * bilateral inguinal hernia operation * nerve injury from other causes
adjunctive laser for periodontal intrabony defects

Conditions: Periodontitis

Summary: participants with periodontitis and presence of bilateral intrabony defect will be randomised to have one side of the mouth undergo root surface debridement using hand instruments and ultrasonic scaler alone, while the contralateral side will receive the same treatment, with the addition of the er:yag laser. outcomes studies will be periodontal clinical parameters at 3 months, 6 months, 9 months and 12 months after treatment, radiographic parameters at 12 months, patient-reported parameters and laboratory analyses.

the study is a double-masked randomised controlled trial with split-mouth design. participants with periodontitis will be randomised to have one side of the mouth undergo root surface debridement using hand instruments and ultrasonic scaler alone, while the contralateral side will receive the same treatment, with the addition of the er:yag laser. outcomes studies will be periodontal clinical parameters at 3 months, 6 months, 9 months and 12 months after treatment, radiographic parameters at 12 months, patient-reported parameters and laboratory analyses.

Eligibility criteria:
inclusion criteria: * minimum of 20 teeth. diagnosis of severe periodontitis (diagnosis of periodontitis stage iii or iv (grade a, b or c) (tonetti et al. 2018) presence of at least 2 teeth with ≥ 6 mm pockets and minimum of 3 mm intrabony defect, in opposing quadrants of the upper or lower arch. exclusion criteria: * inclusion: minimum of 20 teeth. diagnosis of severe periodontitis (diagnosis of periodontitis stage iii or iv (grade a, b or c) (tonetti et al. 2018) presence of at least 2 teeth with ≥ 6 mm pockets and minimum of 3 mm intrabony defect, in opposing quadrants of the upper or lower arch. exclusion: * wearing of a removable appliance/denture * wearing of orthodontic appliances. * current smoking - any history of smoking or vaping within last 5 years * relevant medical history likely to affect periodontal disease or taking relevant medication, including diabetes, as judged by the examining clinician * periodontal treatment (surgical/non-surgical root surface debridement under local anaesthesia) within last 12 months, as judged by the examining clinician * history of any antibiotic use within last 3 months. * pregnant patients * teeth with hopeless prognosis indicated for extraction (cortellini et al 2011) * patients with a non-adequate level of english
wearable technological device applied to patients with chronic pain

Conditions: Neck Pain; Low Back Pain; Chronic Pain; Musculoskeletal Pain

Summary: within the scope of this research, a single session of wearable technological device (exopulse molli-suit) will be applied to patients with chronic back and neck pain. the results will be evaluated acutely, after 24 hours, after 1 week and after 1 month.

after initial evaluations, patients received a single session for 1 hour. exopulse mollii suit will be applied. the stimulation level of the electrodes will be determined by the automatically by the system in accordance with the level of pain they indicate for their parts, individually tailored to the person. will be created. patients will wear the exopulse mollii suit, which is suitable for their body size, hacettepe university physics they will dress in the room allocated for them at the faculty of treatment and rehabilitation. after each use the hygiene of exopulse mollii suits has been evaluated at hacettepe university faculty of physical therapy and rehabilitation in this will be provided with the help of a special device included in the scope. initial assessments will be made immediately will be repeated three more times: after the intervention, 24 hours after the intervention and 4 weeks after the intervention. all data will be collected face-to-face from patients using the instruments mentioned above.

Eligibility criteria:
inclusion criteria: * being between the ages of 20-65 * pain intensity should be at least 5 according to a numeric scale (low back pain and neck pain) * no pain for at least 6 months (healthy people) exclusion criteria: * malignant condition, * people with systemic diseases such as neurological, psychological, cardiovascular, rheumatologic diseases and loss of function due to these diseases, * history of previous surgery on the spine and upper extremities, including the cervical and lumbar region, * fractures in the spine and upper extremities, including the cervical and lumbar region, with a history of inflammation, * acute infection, * attending another rehabilitation program, * refused to participate in the study and did not give written informed consent
randomized clinical trial in bellow-the-knee angioplasty. treatment of one or more than one artery.

Conditions: Atherosclerosis of Artery

Summary: it is a randomized study that intend to enroll 80 bellow-the-knee angioplasty procedures in which 40 procedures to treat one artery (standart) or more than one artery in the same procedure. the aim of this study is to know if this strategy increase healing velocity and limb salvage.


Eligibility criteria:
inclusion criteria: * occlusion of the three arteries bellow the knee previously * rutherford 5 - ischemic lesion of the foot * informative term * at least one patente vessel in pedal arch exclusion criteria: * allergy to aspirin, clopidogrel or contrast media * renal impairment * tasc d lesion in femoral or popliteal arteries * no undersatnting patients

Keywords: angioplasty infrapopliteal arteries
the effect of a ketogenic diet on the exercise induced immune response

Conditions: Upper Respiratory Tract Infections

Summary: comparing the exercise induced immune response after two weeks on a low carbohydrate (ketogenic) diet with the response after two weeks on a high carbohydrate diet.

a cross-over intervention study, with a total duration of 6 weeks. an athlete follows a high, or low carbohydrate (ketogenic) diet. after 2 days a test day takes place where the athlete performs an exercise test and blood samples are taken at different time points. after that, the athlete continues following the diet for another 12 days, after which he comes back again for another identical test day. then a 2 weeks wash-out period. after that, the athlete follows the same protocol but then with either the low (ketogenic), or high carbohydrate diet.

Eligibility criteria:
inclusion criteria: * male * age: 18 - 45 y * bmi: 18.5 - 25 kg/m2 * hb ≥ 8.5 mmol/l, determined with blood sample from finger tip * minimal of 3 hours of training per week, and a maximum of 10 hours * dktp (diphtheria, pertussis, tetanus and polio) vaccinated (for stimulation of isolated cells (pbmc's) with tetanus toxoid) * no asthma medication and/or anti-inflammatory medication * no use of immunosuppressive medication * no flu and/or travel vaccinations in the 4 months before and during the study * able to be present and participate at all test days * willing and able to follow prescribed 2 times a diet for 2 weeks in a row exclusion criteria: * chronic illness * food allergies (e.g. nuts, gluten, avocado) * vegetarian diet * blood donations during study or in the 2 months prior to the study * use of immunosuppressive medication * flu and/or travel vaccination 4 months before and during the study * hb \< 8.5 mmol/l * working at "human nutrition" - wageningen university
the microbiologic profile of diabetic foot infections in turkey - turk-day

Conditions: Infection

Summary: to determine the causative microorganisms and their antibiotic sensitivity patterns in diabetic patients with a foot infection in turkey.

recent studies have demonstrated substantial variation in the etiology of dfis (diabetic foot infections) in different regions of the world . in contrast to western countries, studies from asia and africa have demonstrated that aerobic gram-negative organisms, particularly pseudomonas aeruginosa, are far more common . the majority of current guidelines for the management of dfis have been prepared in western countries . based on the results of more recent studies from the asian continent, however, empiric antibiotic therapy for dfis may need to be directed at organisms with substantially different antibiotic susceptibility patterns than those recommended in current guidelines. thus, suggested antibiotic regimens for dfis should be optimized for local clinical practice. the aim of the current trial is to provide an up-to-date view of the causative microorganisms and their antibiotic sensitivity patterns in diabetic patients with a foot infection in turkey.

Eligibility criteria:
inclusion criteria: * established diagnosis of diabetes mellitus * diabetic foot wound clinically diagnosed as infected exclusion criteria: -

Keywords: diabetic foot infections microorganisms
digital heath integration with neuromodulation therapies on diabetic neuropathy

Conditions: Diabetic Neuropathies

Summary: this study will be carried out on 60 patients both gender male and female with diabetic neuropathy with age55-65 years. the patients will be selected from elmahmoudia hospital .patients will be randomly assigned to two groups.

experimental group: this group will include 30 type ii diabetic patients with peripheral neuropathy patients will receive tens and nmes for 30 minutes 3 days per week,for 10 weeks with medical treatment. control group: this group will include 30 type ii diabetic patients with peripheral neuropathy patients will receive placebo tens and nmes for 30-min sessions, 3 days per week, for 10 weeks with medical treatment.

Eligibility criteria:
inclusion criteria: * 1. diagnosis of diabetes based on world health organization (who) with ages from 55to 65years 2. bmi\> 25kg/m2 3. clinically diagnosed with diabetic neuropathy. 4. all patients are taking oral hypoglycemic drugs with controlled diabetes mellitus. 5. willingness to comply with the study procedures and interventions. 6. ability to provide informed consent. 7. presenting with distal symmetric polyneuropathy (dspn) based on a score of ≥7 on the validated michigan neuropathy screening instrument (mnsi) questionnaire. 8. exhibiting moderately controlled blood pressure exclusion criteria: * 1. presence of other significant neurological or musculoskeletal disorders that may confound the assessment of outcomes. 2. severe cognitive impairment or inability to provide informed consent. 3. any recent surgical procedures or major medical events that could affect the study outcomes. 4. fracture. 5. heart failure. 6. uncooperative patients. 7. anemic patient. 8. patients with liver diseases. 9. smokers patients. 10. any cardiac pacemaker, automatic implantable cardioverter defibrillator (aicd), or other implanted electrical device 11. an existing deep vein thrombosis (dvt) 12. any metal implants 13. current foot ulceration or other lower limb skin ulcers 14. any other cause of neuropathy
analysis of the genotype/phenotype relationship in the fuchs' corneal endothelial dystrophy in france.

Conditions: Fuchs Endothelial Corneal Dystrophy

Summary: the pathophysiology of the most common corneal endothelial dystrophies (fuchs' corneal endothelial dystrophy (fecd)) is beginning to be dismembered. one of the most common genetic anomalies is a triplet repetition in one of the introns of the transcription factor 4 (tcf4) gene located on chromosome 18. however, the number of repetitions varies greatly from one patient to another.

the intent of that study was to analyse if there is a relationship between the number of triplet repetitions and the rate of disease progression. this knowledge would make it possible to personalize the care.

Eligibility criteria:
inclusion criteria: for patient group: * \>18 years old * affiliated with or entitled to a social security scheme * having received informed information about the study and having co-signed, with the investigator, a consent to participate in the study * with an fuchs endothelial corneal dystrophy (fecd) certified by slit lamp examination for control group: * \>18 years old * affiliated with or entitled to a social security scheme * having received informed information about the study and having co-signed, with the investigator, a consent to participate in the study exclusion criteria: for patient group: * patients under guardianship or curatorship * patient planning to move within the year * with no evidence of ophthalmological pathology requiring intraocular surgery within one year of the first visit * better initial corrected visual acuity \<1/10 * not having had intraocular surgery in the 6 months prior to inclusion (after 6 months, the endothelium is considered stabilized) * not having any other progressive pathology responsible for a decrease in visual acuity (significant cataract lens opacities classification system (locs) \>2 ; progressive retinal pathology, in particular age-related macular degeneration, unstabilized macular edema) for control group: * patients under guardianship or curatorship * with an fuchs endothelial corneal dystrophy (fecd) certified by slit lamp examination

Keywords: cornea fuchs endothelial corneal dystrophy (fecd) slit lamp transcription factor 4 (tcf4) chromosome 18 genetic
zostavax™ administered concomitantly with pneumovax™ 23 (v211-012)(completed)

Conditions: Herpes Zoster; Pneumococcal Infection

Summary: the purpose of this study is to determine whether zoster vaccine live and pneumococcal vaccine, polyvalent are as well tolerated and immunogenic when the vaccines are given together (in different body sites), as when they are given alone, in adults 60 years of age and older.


Eligibility criteria:
inclusion criteria: * 60 years of age or older * stable underlying conditions * postmenopausal if female * afebrile exclusion criteria: * previously vaccinated with either vaccine * immune deficiency * history of allergy to components in either vaccine * concomitant antiviral therapy
permethrin-treated baby-wraps for the prevention of malaria in children

Conditions: Malaria; P. Falciparum

Summary: the scientific objective of this study is to test the protective effect of permethrin-treated lesus against p. falciparum malaria in infants and young children.

general study design: the proposed study is a double-blind, randomized control trial of permethrin-treated lesus to prevent p. falciparum malaria in children 6-24 months of age conducted at two sites in rural western uganda. participating mother-infant pairs will receive a new bed net and two permethrin-treated or untreated lesus at enrollment. the total sample size will be 400 mother-infant pairs with 200 pairs in each group. the investigators will follow participants longitudinally for six months. participants will be instructed and incentivized to present to one of the two study clinics when a fever develops, where they will be evaluated, tested, and treated, if positive, for malaria. participants will also attend scheduled clinic visits every two weeks for routine surveillance of adverse effects and to test for asymptomatic infection. re-treatment and sham re-treatment of lesus will occur each month. outcome measures: the primary outcome measure is the incidence rate ratio of clinical (i.e., symptomatic) p. falciparum malaria in infants and children 6 - 24 months of age. differences in malaria infection between treatment groups will be estimated with the incidence rate ratio, defined as the ratio of the number of clinical malaria episodes per 100 person-weeks at risk in the intervention group relative to the control group. this measure was chosen as it represents the most patient-centered measure of malaria burden, reflecting not only the potential negative health consequences, but also opportunity costs associated with care seeking and treatment.

Eligibility criteria:
inclusion criteria: * provide signed and dated informed consent form (icf) * willing to comply with all study procedures and be available for the duration of the study * female of any age with a child 6 to 18 months of age at the time of enrollment * resident of village located in bugoye, maliba, or mubuku sub-counties. recruitment will initially focus on residents of villages within 2 km of study clinics in order to facilitate attendance, but we will not restrict enrollment to residents of these villages. exclusion criteria: * mother or child taking any malaria chemoprevention regimen, including individuals living with hiv or exposed children who are taking cotrimoxazole that may modify risk of malaria * child with known sickle cell disease * known allergic reactions to components of the study product(s) * treatment with another investigational drug or other intervention * anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.

Keywords: permethrin plasmodium falciparum infection insecticide malaria
osteoarthritis relationships and tobacco " ancillary study khoala "

Conditions: Osteoarthrosis

Summary: the role of tobacco in osteoarthritis remains controversial. the khoala cohort is the first multicenter french cohort of subjects with knee and / or hip osteoarthritis prevalent . it guarantees its methodology great representativeness and therefore an interesting material for the study of risk factors in the population. in addition, it should have little here radiographs of hands for all its patients. it therefore has the opportunity to study a possible relationship between tobacco and hip osteoarthritis , knee and hand but also to study the relationship between tobacco and structural evolution of hip osteoarthritis and / or symptomatic knee.


Eligibility criteria:
inclusion criteria: * men or women aged between 40 and 75 years * hip osteoarthritis and / or knee ( stifle ) , unilateral or bilateral , symptomatic with a confirmed diagnosis and meeting the acr criteria , representative of prevalent cases in france during the constitution of the cohort * affiliation to social security exclusion criteria: * presence of a hip or knee prosthesis of the painful joint at baseline ; * antecedent osteotomy ; * severe comorbidity likely to affect significantly the quality of life or induce a major healthcare consumption regardless of osteoarthritis ; * knee pain with patellofemoral osteoarthritis isolated , that is to say without tibiofemoral osteoarthritis associated ; * other pathologies of these joints * adults subject to a legal protection measure or unable to express their opposition not to participate in the study
prospective analysis of incidence and risk factors of infection of midline catheter

Conditions: Intravascular Device

Summary: the midline catheter is a peripherally-inserted catheter, with the distal tip being placed at or below the level of the axilla. it is a relevant alternative to other catheters in case of limited venous access and long-run perfusions. moreover, another significant advantage may be the reduction of the risk of infection. however, the midline catheter is poorly described in scientific literature, essentially through retrospective and meta analyses including multiple types of catheters (piccline, cvc, pac). therefore, the tim-ghm study aims to prospectively assess the rate of infections in case of the midline catheter. the results of this study could bring a collective benefit in terms of knowledge and reliability of these intravascular devices. depending on these results, a randomized, controlled study will be considered, in order to compare the midline catheter to its main alternative : the piccline.


Eligibility criteria:
inclusion criteria: * age superior or equal to 18 years old * intravascular treatment planned for more than 6 days exclusion criteria: * medical history of mastectomy with bilateral lymphadenectomy * peripheral neuropathy * upper-extremity deep vein thrombosis * arteriovenous fistula * poor condition of the skin of the upper limbs * patient in palliative care * patient in emergency care * patient under guardianship/curatorship * pregnant or breastfeeding women