Kornimate/medical-research-clean huggingface dataset:
effect of perioperative iv dexmedetomidine vs. lidocaine on postoperative pain, analgesic consumption and recovery after abdominal gynaecological surgery

Conditions: Hysterectomy; Myomectomy

Summary: postoperative pain continues to be inadequately managed and is the most common reason for the delay in discharge and unplanned hospital admission after surgery. opioids remain the mainstay for postoperative analgesia. however, there is a continuous search for adjuvant therapies to reduce the doses of opioids and their related adverse effects, and extend the use of non-opioid analgesia for acute pain after abdominal surgery, thereby improving patient recovery. currently there are no clinical trials that investigate the effect of intravenous lidocaine vs dexmedetomidine on postoperative pain, analgesic consumption and bowel function of patients undergoing abdominal gynaecological surgery. purpose of this prospective double blind randomised clinical trial is the investigation of the effect of perioperative intravenous infusion of lidocaine vs dexmedetomidine vs placebo (normal saline 0,9%) on analgesic parameters and functional recovery of patients undergoing abdominal gynaecological surgery.


Eligibility criteria:
inclusion criteria: * women * asa i-ii * 30-70 years * abdominal gynaecological surgery exclusion criteria: * patient's refusal * contraindication to the use of local anesthetics * body mass index \>30 kg/m2 * history of cardiovascular diseases/ arrhythmias/ conduction abnormalities * pregnant women * significant renal or hepatic impairment * insulin-dependent diabetes mellitus * central nervous system disease or psychiatric diseases * chronic use of opioids, steroids, clonidine (or other a2 agonist) * use of drugs acting on the central nervous system or analgesics during the previous 2 weeks * drug/alcohol abuse * inability to comprehend the following pain assessment scale

Keywords: dexmedetomidine lidocaine postoperative pain analgesic consumption recovery abdominal gynaecological surgery
the effect of inspiratory muscle strength training in healthy adults with forward head posture

Conditions: Posture

Summary: forward head posture (fhp) is defined as the position in which the head is in front of the shoulder and is one of the most common musculoskeletal problems caused by the increasing use of computers and smartphones. posture analysis, pulmonary function test, respiratory muscle strength and endurance assessment, and performance test will be performed as the initial evaluation for those who meet the inclusion criteria and volunteer to participate in the study. participants with a craniovertebral angle of 50 degrees and less than 50 degrees will be included in the head forward posture (fhp, n=34) group, and participants with an angle of more than 50 degrees will be included in the control group (cg, n=34).participants with hfp will be randomly divided into two groups as study (fhp-s, n=17) and control (fhp-c, n=17). an inspiratory muscle strength training program will be applied to the fhp-c group for 7 days/6 weeks. all assessments performed before the training will be repeated after 6 weeks of inspiratory muscle strength training. no inspiratory muscle strength training will be applied to the fhp-c group. participants in the cg group will not undergo any additional assessment or training.

forward head posture (fhp) is defined as the position in which the head is in front of the shoulder and is one of the most common musculoskeletal problems caused by the increasing use of computers and smartphones. posture analysis, pulmonary function test, respiratory muscle strength and endurance assessment, and performance test will be performed as the initial evaluation for those who meet the inclusion criteria and volunteer to participate in the study. participants with a craniovertebral angle of 50 degrees and less than 50 degrees will be included in the head forward posture (fhp, n=34) group, and participants with an angle of more than 50 degrees will be included in the control group (cg, n=34).participants with hfp will be randomly divided into two groups as study (fhp-s, n=17) and control (fhp-c, n=17). an inspiratory muscle strength training program will be applied to the fhp-c group for 7 days/6 weeks. all assessments performed before the training will be repeated after 6 weeks of inspiratory muscle strength training. no inspiratory muscle strength training will be applied to the fhp-c group. participants in the cg group will not undergo any additional assessment or training.

Eligibility criteria:
inclusion criteria: * cranio-vertebral angle (cva) of 50 degrees and less than 50 degrees exclusion criteria: * diagnosed respiratory, neurological, orthopedic, psychiatric or cardiac problems * have any infection at the time of assessment and training, * having any limitation that prevents assessment and training * pregnancy or breastfeeding * having a history of neck trauma * having undergone lumbar-neck surgery
efficacy study of liraglutide vs.sitagliptin vs. glargine on liver fat in t2dm subjects

Conditions: Non-alcoholic Fatty Liver Disease

Summary: the aim of this study is to explore the effectiveness of liraglutide combined with metformin in non-alcoholic fatty-liver disease patients with type 2 diabetes mellitus (t2dm) compared to sitagliptin and insulin glargine in combination with metformin.

this is a 26-week, randomized, open-label, active controlled, parallel group, multi-centre trial.to compare the change of intrahepatic lipids (ihl) as measured by magnetic resonance spectroscopy(mrs) or mri estimated proton density fat fraction (mri-pdff) as measured by mri ideal iq (iterative decomposition of water andfat with echo asymmetryand least-squares estimation) in type 2 diabetic patients with non-alcoholic fatty-liver disease after a 26-week treatment of liraglutide, sitagliptin or insulin glargine per day combined with metformin.the primary endpoint will be defined by intrahepatic lipids (ihl) as measured by magnetic resonance spectroscopy (mrs) or mri-pdff as measured by mri ideal iq.

Eligibility criteria:
inclusion criteria: * recorded type 2 diabetes diagnosed at least 3 months before the study; at least 3 months treatment on a stable dose（≧1500mg/d）of metformin before the study * 6.5%\<hba1c ≤10% * clinically diagnosed simple liver steatosis * 30-75 years old * female subjects should be postmenopausal, surgically sterile, or using contraceptives for 3 months before screening and continuing throughout the study; * bmi 20\~35 kg/m2 and with a history of stable body weight (≤10%variation for ≥3 months) * intrahepatic lipids (ihl) \>10% exclusion criteria: * type 1 diabetes * treatment within the last 3 months with thiazolidinediones(tzds), orlistat, insulin, any history of incretin based therapy or any other drugs associated with hepatic steatosis (including but not limited to glucocorticoids, tamoxifen, amiodarone or methotrexate) * history or current episode of pancreatitis or other disease of the pancrea; impaired liver function, defined as plasma alanine transaminase(alt) \>2.5 times of upper normal limit * moderate and severe renal insufficiency defined as mdrd formula glomerular filtration rate\<60ml/min/1.73m2 * weekly alcohol intake\>14 units for women or \>21 units for men * any history of liver disease including metabolic or auto-immune liver diseases or viral hepatitis * history or family history of medullary thyroid cancer(mtc), or multiple endocrine neoplasia type 2(men-2) * congestive heart failure(nyha iii\~iv) * severe gastric-intestinal diseases * pregnancy and/or intention of becoming pregnant * known proliferative retinopathy or maculopathy requiring acute treatment as judged by the investigator; use of non-herbal chinese medicine or other non-herbal local medicine with unknown/unspecified content. herbal traditional chinese medicine or other local herbal medicines may, at the investigator's discretion, be continued throughout the trial at an unchanged dose

Keywords: non-alcoholic fatty liver disease glucagon-like peptide-1 receptor agonists diabetes mellitus, type 2
influence of postoperative rehabilitation and pre- and postoperative physical activity in abdominal surgery

Conditions: Abdominal Injuries

Summary: the concept of early rehabilitation (eras: enhanced after-surgery recovery) was introduced by kehlet et al. in 1995, as part of the colon surgery. this program is a support for patients combining laparoscopic surgery, epidural analgesia, early refeeding and rapid mobilization of patients. this strategy targets multiple elements (20 items) to support pre-, intra- and postoperative patients. this reduces the pain and the different organ dysfunction induced by surgical stress significantly decreasing length of hospital stay, postoperative morbidity and costs. furthermore, early mobilization of patients is fundamental to the eras method. few studies have analyzed the influence of preoperative exercise on postoperative rehabilitation.


Eligibility criteria:
inclusion criteria 1. non-cancerous and cancerous pathology 2. signed consent 3. every patient operated on a scheduled or emergency abdominal surgery exclusion criteria 1. inability to give informed about information 2. minor patient

Keywords: early rehabilitation abdominal surgery eras
falls prevention and balance rehabilitation in multiple sclerosis

Conditions: Multiple Sclerosis

Summary: background. balance disorders and falls are common in people with multiple sclerosis (pwms) objective: our hypothesis was that pwms treated for balance disorders would reduce balance disorders and frequency of falls. methods: a bi-centre randomised rater-blinded controlled trial. participants in both groups received 20 treatment sessions. participants in the intervention group received treatment aimed at improving control of the position and movement of the centre of mass and body segments. participants in the control group received treatments to reduce limitations at activity and body function level. group allocation was done by an independent clinician by a randomization list made before the beginning of the study. group allocation was kept concealed throughout the study and participants were not aware of group assignment. data was analyzed according to a preplanned protocol by using an intention to treat approach.


Eligibility criteria:
inclusion criteria: clinical diagnosis of multiple sclerosis must be able to walk (also with aid) for 6m must be able to maintain standing position with open eyes for at least 30". exclusion criteria: must not be able to maintain monopodalic-standing position for 10", must not be able to to maintain tandem position for 30", cognitive disorders hampering the execution of the exercises/assessment.
the compassion study

Conditions: Breast Cancer; Metastatic Breast Cancer; Advanced Breast Cancer; Unresectable Breast Carcinoma

Summary: the aim of this research study is to better understand the in-home hospice experience for participants, caregivers, hospice nurses, and oncology providers by conducting telehealth check-ins between participants and caregivers and oncology care teams.

the aim of this research study is to better understand the in-home hospice experience for participants, caregivers, hospice nurses, and oncology providers by conducting telehealth check-ins between participants and caregivers and oncology care teams. study procedures include giving verbal consent to participate and a one-time survey delivered by email or phone call. about 200 people, which includes 50 participants, 50 caregivers, 50 hospice nurses, and about 50 oncology providers, are expected to participate in this research study.

Eligibility criteria:
inclusion criteria: * patient of any gender with unresectable locally advanced or metastatic breast cancer * eligible for in-home hospice services and referred by dfci clinical team to in-home hospice \</= 1 week before enrollment * ability to conduct video or phone check-ins, even if assistance required. * able to provide verbal consent with a willingness to take a survey at 4-6 weeks, if medically able * hospice setting is within massachusetts * non-english language allowed but interpreter services must be present at each meeting and will be coordinated by scheduling team * willingness to provide a caregiver/loved one's contact information for survey contact at 4 weeks after enrollment exclusion criteria: * unable to provide verbal consent * hospice care planned outside of a home setting (note: if participants start out in a home hospice setting but later transition their hospice care to an inpatient setting, enrollment is allowed as long as they started in a home setting) * hospice setting outside of massachusetts * individuals who are under the age of 18, as this is not a project focused on pediatric patients.

Keywords: breast cancer metastatic breast cancer advanced breast cancer unresectable breast cancer hospice care
normal and small size mesh in open inguinal herni repair

Conditions: General Surgery; Inguinal Hernia; Ventral Hernia

Summary: recent years, lots of treatment teqnique have development. we aimed that comparising the normal and small size meshes in the inguinal hernia patients.

data collection method: the research will be a multicentric, prospective and randomized clinical study to be conducted between 01.11.2018 and 28.02.2019 by the general surgery clinics of mogadishu-somalia recep tayyip erdogan training and research hospital and health sciences university konya training and research hospital. male patients with inguinal hernia repair will be included in the study. patients will be randomized into two groups. while the normal size of 15 x 7 cm (105 cm2) mesh was used in the first group, in the second group, a small size 11 x 5 cm (55 cm2) mesh will be used. dismissal criteria are; female patients, relapse hernias, bilateral inguinal hernia, laparoscopic hernia repair, diabetic patients using insulin, patients with copd, peripheral vascular disease, emergency inguinal hernia repair, patients with high asa score, patients with serious cardiological problems, heavy smokers, transfusions during the perioperative period. patients will be given clear and understandable information about the study. patients who agree to participate in the study will receive a consent form explaining that they have participated in the study voluntarily. randomization is done by the secretary with a computer program. a note stating which group the patient is in is placed in a closed envelope and an envelope is opened at the preoperative surgery table. the method of operation will be open inguinal hernia repair (lichtenstein hernia repair). the patient will be repaired with mesh suitable for the randomization group. operations will be performed under the supervision of an experienced surgeon or experienced surgeon. surgical method: patients will receive open inguinal hernia repair, known as lichtenstein hernia repair. according to the gilbert classification, the hernia type is recorded in the patient file. evaluation of patient characteristics and pain: the researcher will not know in which group the patients are. demographic features, duration of surgery, hernia type, early postoperative complications, return to work will be recorded in the study forms. if there is a suspicion of recurrence in the physical examination, a recurrence assessment will be performed by ultrasonography and magnetic resonance examination if necessary. recurrences will be detected at 1, 6, 12, and 24 and recorded on the study form. values will be recorded in the form by using the sheffield scale in the assessment of chronic pain.

Eligibility criteria:
inclusion criteria: * ages must be upper 18 exclusion criteria: * morbit obesity (bmi\>40)

Keywords: mesh size lichtenstein hernia repair surgical technique
the effect of myopic optical defocus on the humphrey matrix 30-2 test

Conditions: Myopia

Summary: the purpose of this study is to examine the effect of the myopic optical defocus on the humphrey matrix 30-2 test.

the humphery matrix (zeiss, dublin, california, usa; in cooperation with welch allyn, skaneateles, new york, usa), which is a recently developed version of fdt perimetry, showed more improved technology to detect early glaucomatous damage. the user's guide for the humphrey matrix (humphrey® matrix visual field instrument user's guide. zeiss, dublin, california, usa; in cooperation with welch allyn, skaneateles, new york, usa; 2003) suggests that myopic refractive errors more than -3.0 d need to be corrected before the 30-2 test. however, the proper correction of the optical defocus is not always easy because of a lack of trial frame. the purpose of the present study is twofold. at first, the influence of the low-grade myopia on the humphery matrix 30-2 test will be evaluated and compared to the effect of moderate-grade myopia. secondly, the influence of myopic optical defocus and the glaucomatous visual field damage on the pattern deviation plot change according to the severity of glaucomatous visual field damage will be estimated.

Eligibility criteria:
inclusion criteria: * intra-ocular pressure 23 or higher * suspicious glaucomatous optic disc change * suspicious defect of retinal nerve fiber layer * or eyes with various degrees of glaucoma exclusion criteria: * a high myopic eye (se more than -6.0 d) * moderate to severe cataract * evidence of diabetic or hypertensive retinopathy * macular disease * intra-ocular inflammation * history of intraocular surgery and any other ocular lesion that could have an influence on the perimetry result

Keywords: myopia humphery matrix 30-2 test
pain management at latent period of labour

Conditions: Labour

Summary: examine the effectiveness of an analgesic in perfalgan maternity latent phase of labor. examine the safety in perfalgan in the mother and the newborn in terms of the level of drug in blood

maternity are latent or first stage of labor and complained of pain at the level of 4 or higher on a scale vas, and are not in risk (high risk). and did not receive analgesics within 4 hours. the sample will consist of at least 100 women in labor. 1. women, will be identified in the reception room of a delivery room by midwives. 2. the research team will ask for consent after receiving an explanation and confirmation of understanding. 3. the midwife will perform and will record pain assessment by visual analog scores . 4. maternity reported pain level 4 and above will be asked four questions out of data collection and offered them treatment i.v. paracetamol 1gr as directed by the physician. 5. after giving i.v. paracetamol 1g, carried out and documented estimate of the pain returns (by visual analog scores) after an hour wait at any time to wait four hours and two hours after birth. in cases of an outbreak of pain can give one of the following: option a: another portion of the i.v. paracetamol 1gr within 4-6 hours the previous dose. the maximum daily dose of 4 grams. option b: n2o by procedure a third possibility: epidural physician approval 6. at the end of the birth fetal blood sample taken from the placenta for testing the level of paracetamol. 7. at the end of a blood sample taken birth for the client in liver function tests. 8. interview woman with postpartum questionnaire will be made during her stay in the maternity ward. filling out a questionnaire that includes demographic data and about the process of birth, medical records.

Eligibility criteria:
inclusion criteria: * latent phase of labour * low risk exclusion criteria: * high risk * allergy to paracetamol * liver insufficiency
cortisol and food insecurity

Conditions: Food Insecurity

Summary: this study will use a within-subjects design in a sample of individuals with a range of food insecurity recruited from the los angeles community (n = 400; 50% men). these participants will then, in counterbalanced order, be exposed to a gold-standard laboratory stressor and a control condition, one month apart. moderation analyses will test whether cortisol reactivity to the stressor acts as a modulator of the relationship between high levels of food insecurity and increased hyperpalatable food intake.


Eligibility criteria:
inclusion criteria: * age 18+ * english-speaking exclusion criteria: * recent (\<1 year) diagnosis of major psychiatric disorders including any mood disorder, schizophrenia, or ptsd * recent (\<1 year) diagnosis of eating disorder * recent (\<1 year) diagnosis of metabolic or endocrine disorder or steroid or hormonal contraceptive use * pregnancy * allergy to any of the foods in the food buffet * participation in strict dieting or caloric restriction

Keywords: food insecurity physiological stress psychological stress cortisol eating diet
multicenter evaluation of children and young adults with genotype positive long qt syndrome

Conditions: Long QT Syndrome

Summary: the purpose of the study is to provide comprehensive follow-up in patients with long qt syndrome (lqts) and gain additional information regarding genotype-phenotype correlation and effective management and treatment options.


Eligibility criteria:
inclusion criteria: * children and/or young adults diagnosed with heterogeneous repolarization disorder who have genotype positive long qt, or * newly diagnosed mutation positive patients with a confirmed test exclusion criteria: * children who are phenotypically positive with no molecular testing * children that are phenotypically positive but genotype negative
management strategy for mild to moderate major depression: combination of rhodiola and saffron extracts.

Conditions: Mild to Moderate Depression

Summary: the purpose of the study is to describe, over 6 weeks, the evolution of depressive symptoms in patients with mild to moderate major depression in a strategy with phytostandard® rhodiola-saffron supplementation

for this study, 52 patients are going to be included. they will have a supplementation of phytostandard® rhodiola/saffron, from 2 tablets per day during 42 days. on the one hand, during the two visits (inclusion and follow-up), the investigator completes the hamilton depression scale (ham-d) and the clinical global impression (cgi). during the inclusion visit, he completes with his patient cim-10 for depression diagnostic. on the other hand, patients complete had 4 times : just after the inclusion visit, at day 14, at day 28 and just before the follow-up visit. he completes the patient global impression too at each time.

Eligibility criteria:
inclusion criteria: * suffering from mild to moderate depression as defined in cim-10 * having a score on the ham-d questionnaire between 8 and 18 * having agreed to participate at the study after being informed by the investigator exclusion criteria: * depressive patients already under medication or discontinuation of medication less than a month ago * patients with severe depression as defined in cim-10 or ham-d\> 18 * patients considered at risk: attempted suicide or suicidal (observed by the investigator or hamilton item 3 score\> 2) * patients with psychiatric disorders: schizophrenia, bipolarity, addiction (drugs, alcohol ...), etc. * patient with severe disease (cancer, kidney or heart disease) or patient with a contra-indication for taking the product (patient under anti-hypertensive ...) * patients using agents containing piperine or st. john's wort (interactions) * pregnant or breastfeeding patients * patients who do not wish to complement phytostandard® rhodiola - saffron. * patients who do not wish to participate in the study. * patients unable to understand the ins and outs of the study (mental incapacity, language barrier).