Kornimate/medical-research-clean huggingface dataset:
enhancing walking in people with incomplete spinal cord injury: a pilot study

Conditions: Motor-incomplete Spinal Cord Injury

Summary: the research proposed here will determine the effect of a novel treadmill gait training strategy using a robotic gait trainer (the lokomat) on functional ambulation in people with sci. the effect of the new therapy will be evaluated by analyzing changes in functional ambulation and gait patterns during walking.

community-dwelling individuals with motor-incomplete spinal cord injury will be recruited. in total, 20 participants will be recruited and randomly assigned to one of 2 types of body-weight supported treadmill training (bwstt) with the lokomat, which differ only in the level of assistance that the lokomat provides to the leg movements while walking. therapy for both groups will take place 3 times/week for 12 weeks. during each session, participants will first complete a 10-minute warm-up period followed by 45 minutes of the assigned therapy. rest breaks will be provided as needed, but participants should complete 45 minutes of walking per session.

Eligibility criteria:
inclusion criteria: 1. motor-incomplete sci due to non-progressive lesion (e.g. trauma, ischemia) at least 12 months ago 2. 19 to 65 years of age 3. use of standing or walking as part of typical activities of daily living 4. controlled spasticity (stable administration of anti-spasticity medication) for the duration of the study exclusion criteria: 1. lesion below 11th thoracic level (lower motoneuron injury) 2. weight greater than 300 lbs or height greater than 6'1" 3. femur length \ 47 cm and body weight \>150 kg 4. cardiac, musculoskeletal, or other uncontrolled health condition (e.g. orthostatic hypotension, osteoporosis) for which exercise or treadmill activity is contra-indicated 5. existing skin irritation or open wounds/sores in lower extremity areas in contact with the leg cuffs of the lokomat or body weight support harness 6. existing cognitive impairment (as indicated by a cognitive capacity screening examination (ccse) score of less than 24 out of 30) 7. participation in rehabilitation therapy or other research study with exercise or mobility outcomes

Keywords: spinal cord injury walking gait training body-weight supported treadmill training rehabilitation
development of synthetic medical data generation technology to predict postoperative complications

Conditions: Acute Kidney Injury; Surgery-Complications; Nephropathy

Summary: \ in order to develop a model for predicting the occurrence of complications after surgery, it is necessary to establish a cohort along with statistical indicators related to the occurrence of complications. this study aims to combine synthetic medical data based on actual clinical data and develop a predictive model based on synthetic medical data. this will allow researchers to conduct research only with synthetic data without dealing with actual medical data, allowing them to use and process data without legal constraints, and to create as much data as they want based on various preprocessed, standardized, and labeled raw data. patients from three hospitals in korea (seoul national university hospital, seoul national university bundang hospital, seoul metropolitan city-boramae medical center) were enrolled for the study. medical data (both clinical and laboratory) from 410,000 patients who were conducted surgery between 2005 and 2020 were collected to evaluate the performance of the prediction model using aki-based prediction model development and external verification. based on the collected patient data, synthetic medical data were combined using the machine learning algorithm, and the anonymity and re-identification of the synthesized medical data were evaluated. also, the development of ai-based prediction model using synthetic medical data and the actual medical data model were compared.


Eligibility criteria:
inclusion criteria: * patients over 18 years. * non-cardiothoracic and non-vascular surgery from five departments (general surgery, obstetrics and gynecology (obgy), urologic surgery, neurosurgery, and orthopedic surgery) exclusion criteria: * 1) no information of baseline (≤90 days before surgery) or follow-up (≤7 days after surgery) renal function * 2) exclusive surgery, including surgeries of deceased patients or surgery that directly affect renal function (partial or total nephrectomy, kidney transplantation) * 3) preoperative advanced kidney dysfunction, including preoperative serum creatinine (scr) ≥4.0 mg/dl, baseline egfr (estimated glomerular filtration rate) \<15 ml/min/1.73 m2, preoperative kidney replacement therapy history, or aki history within 2 weeks of surgery * 4) surgery other than general or spinal anesthesia (local anesthesia or monitored anesthesia care) * 5) missing covariates.
evaluation of the efficacy of a new formula in infants with cow's milk protein allergy

Conditions: Milk Hypersensitivity; Food Sensitivity; Protein Allergy

Summary: the aim of the study is to show the efficacy, tolerance and nutritional adequacy of a newly developed hydrolyzed rice formula in infants with a proven cow's milk protein allergy.


Eligibility criteria:
inclusion criteria: * infants between 2 weeks and 6 months old * in whom cow's milk protein allergy has been proved by a food challenge performed during the previous month exclusion criteria: * exclusively breast fed infants * preterm infants * infants already fed with an extensively hydrolyzed formula with no improvement of the symptoms. * infants fed an amino acid based formula * infants who had an anaphylactic reaction in the past

Keywords: cow's milk protein allergy
a research study to see how much cagrisema lowers blood sugar and body weight compared to placebo in people with type 2 diabetes treated with diet and exercise

Conditions: Type 2 Diabetes

Summary: this study will look at how much cagrisema helps participants with type 2 diabetes lower their blood sugar and body weight. cagrisema is a new investigational medicine. doctors may not yet prescribe cagrisema. cagrisema will be compared to a "dummy" medicine (also called "placebo") that has no effect on the body. participants will get either cagrisema or "dummy" medicine. which treatment participants get is decided by chance. for each participant, the study will last for about one year.


Eligibility criteria:
inclusion criteria: * male or female * age 18 years or above at the time of signing the informed consent * diagnosed with type 2 diabetes \>=30 days before screening * hba1c 7.0-9.5 percent (53-80 millimoles per mole \[mmol/mol\]) (both inclusive) as determined by central laboratory at screening * body mass index (bmi) \>=23 kilograms per square meter (kg/m\^2) at screening. bmi will be calculated in the electronic case report form (ecrf) based on height and body weight at screening exclusion criteria: * female who is pregnant, breast-feeding or intends to become pregnant or is of childbearing potential and not using a highly effective contraceptive method * renal impairment with estimated glomerular filtration rate less than 30 milliliter per minute per 1.73 square meter (ml/min/1.73 m\^2) as determined by central laboratory at screening * treatment with any medication for the indication of diabetes or obesity within 90 days before screening. however, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed * history of use of any injectable therapy for diabetes or obesity. however, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed * uncontrolled and potentially unstable diabetic retinopathy or maculopathy. verified by a fundus examination performed within 90 days before screening or in the period between screening and randomisation. pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination
nutritional and functional assessment of patients undergoing surgery due to gastrointestinal cancer (nufagi).

Conditions: Gastrointestinal Cancer

Summary: several patients that suffer from gastrointestinal (gi) cancer are characterized by malnutrition and impairment of their functional status. the aim of the present study is to evaluate the nutritional condition of patients undergoing surgery due to gi cancer and compare it with their functional status. all consecutive patients with esophageal, gastric, colorectal, hepatocellular, pancreatic and biliary cancer, that underwent a surgical operation will be included. demographic characteristics, nutritional assessment and anthropometric measurements of the patients will be recorded.


Eligibility criteria:
inclusion criteria: * patients undergoing a surgical operation due to esophageal, gastric, colorectal, hepatocellular, pancreatic and biliary cancer. exclusion criteria: * under 18 years old or above 99 years old. * surgery due to benign conditions.

Keywords: nutritional status functional status gastrointestinal cancer
macrophages, gm-csf and mars proteinosis

Conditions: Pulmonary Alveolar Proteinosis (PAP); MARS; Genetic Mutation

Summary: mutations in the mars gene encoding methionyl-trna synthetase are responsible for a genetic form of alveolar proteinosis (pap), but the pathophysiological mechanisms of the respiratory phenotype are not known. the main hypothesis is that the pap phenotype in these patients is secondary to a defective clearance of the surfactant by the alveolar macrophages. the main objective of the study is to study the clearance capacity of lipoproteinaceous material by macrophages of patients with mars related pap. this will be investigate in cultured macrophages derived from peripheral blood monocytes of patients (patients with mars related pap) and controls (patients without mars related pap).

pulmonary alveolar proteinosis (pap) is a rare respiratory disease characterized by the accumulation of lipoproteinaceous material within the pulmonary alveoli, resulting in the majority of cases from a defective clearance of the surfactant by intra-alveolar macrophages. mutations in the mars gene encoding methionyl-trna synthetase are responsible for a genetic form of alveolar proteinosis, but the pathophysiological mechanisms leading to mutations in the respiratory phenotype are not known. the main hypothesis is that the alveolar proteinosis phenotype in these patients is secondary to a defective clearance of the surfactant by the alveolar macrophages. the main objective of the study is to study the clearance capacity of lipoproteinaceous material by macrophages of patients with mars related pap. this will be investigate in cultured macrophages derived from peripheral blood monocytes of patients (patients with mars related pap) and controls (patients without mars related pap). the subjects and the controls will be included during a hospitalization during which a blood sample and a bronchoscopy with broncoalveolar lavage must be performed as part of their care.

Eligibility criteria:
inclusion criteria: * minors from 0 to 17 years hospitalized for their care at necker enfants malades hospital and for whom a blood sample and a bronchoscopy with bronchoalveolar lavage must be performed as part of their care * information and consent of the holders of parental authority and the patient exclusion criteria: - refusal of holders of parental authority or patient

Keywords: pulmonary alveolar proteinosis (pap) mutations in the mars gene methionyl-trna synthetase surfactant clearance alveolar macrophages
efficacy of prolonged gnrh test in male adolescents with postoperative hh

Conditions: Hypogonadotropic Hypogonadism

Summary: the hypogonadotropic hypogonadism(hh) could be caused by sellar lesions, sellar surgery or sellar radiotherapy. the incidence of hh after sellar surgery was higher in men than in women, and the therapy of hh was insufficient. gonadotropin-releasing hormone(gnrh) stimulation test is used to evaluate the function of pituitary-gonadal axis. gnrh can be used to diagnose and treat fertility disorders and other endocrine disorders caused by hh. after a single injection of gnrh, the patients with poor response of luteinizing hormone and follicle stimulating hormone need to take extended provocation test, which is conducive to the formulation of the following treatment. gnrh pump can pulse subcutaneous injection of gonadorelin, which can be used as the extended provocation test.


Eligibility criteria:
inclusion criteria: * patients with hh after surgery of the saddle area * sufficient therapy of the hypothalamic-pituitary-adrenal(hpa) and hypothalamic-pituitary-thyroid(hpt) axis exclusion criteria: * contradictions to gonadorelin * androgen-dependent prostate cancer * on the therapy of human chorionic gonadotropin(hcg) or testosterone
accuracy of the optical diagnosis of small colonic polyps using the nice classification

Conditions: Colon Adenoma; Colorectal Carcinoma; Hyperplastic Polyp

Summary: adenomas and hyperplastic polyps are polypoid lesion and may occur at any location in the colon. at the present moment, all polyps should be resected endoscopically, although only adenomas, but not hyperplastic polyps have the potential to develop colorectal cancer. this approach enables the conduction of microscopic investigations of the lesions. by today, only the pathological diagnosis can distinguish exactly between adenomas and hyperplastic polyps. some studies have investigated the value of the socalled optical biopsy method. optical biopsy means the visual assessment of the polyp and the determination of a diagnosis solely on behalf of optical criteria. this method is conducted in real time during colonoscopy. if it can be shown, that endoscopist using optical biopsy are able to predict histopathological diagnoses of colonic polyps sufficiently this would possibly lead to simplification of diagnostic procedures. for instance, it would be conceivable to resect hyperplastic polyps and small adenomas and discard them without further assessment by a pathologist. gastroenterological societies demand for a 90 percent accordance between diagnoses set by endoscopists and pathologists as a prerequisite for the implementation of the optical biopsy method. in this study we want to proof that the use of a new narrow-band imaging (nbi) tool (exera iii, olmpus) is capable to rise accuracy of optically ascertained diagnoses of colonic polyps. nbi is a light filter tool which can be activated by pressing a button at the endoscope. nbi function leads to an endoscopic picture which appears blue and enables endoscopists to better assess surface structures and vascular patterns. in a prospective randomised multicenter setting we plan to conduct colonoscopy in 380 patients. half of the patients will be examined without use of nbi (control arm). in these cases colonoscopists will assess optical diagnosis of polyps without turning on the nbi tool. if polyps are detected in patients belonging to the intervention arm nbi will be used and optical diagnosis will be determined using the nice (nbi international colorectal endoscopic) classification. all polyps will be resected and send to pathology for further microscopic assessment. after completing the trial we aim to compare accuracy of the optical diagnosis in both groups. our hypothesis is, that by using the new nbi tool accuracy (accordance between optical and histopathological diagnosis) can be increased from 78% to 90%.


Eligibility criteria:
inclusion criteria: * medical indication for colonoscopy * age \>18 years * written consent given by patient exclusion criteria: * age \< 18 years * patients denying written consent * pregnant women * asa class iv, v and vi * known contraindication for polyp resection * indication for colonoscopy: preknown adenoma/polyp/carcinoma * indication for colonoscopy: emergency (e.g. severe rectal bleeding)

Keywords: colonoscopy adenoma detection rate narrow band imaging optical biopsy accuracy
pilot clinical trial of cpc/rhbmp-2 microffolds as bone substitute for bone regeneration

Conditions: Bone Fracture

Summary: objective: the investigators initiated a pilot clinical study to test safety and preliminary efficacy in humans (bone tissue repairing capacity) and to evaluate standard clinical and rehabilitation protocols. summary background data: bone tissue engineering scaffolds loading growth factors have been considered as the most perspective among all bone substitutes, yet little progress of its clinical translation has been made. the concept of "micro-scaffolds" was proposed in this study to provide a trajectory to its clinical translation. methods: pre-cured cpc/rhbmp-2 micro-scaffolds have been successfully developed and further applied as an easy-to-operate filler for bone regeneration in a pilot clinical study. patients of tibial plateau fractures, proximal humeral fractures, or calcaneal fractures at a similar level of severity were randomly divided into two groups and treated by cpc/rhbmp-2 microffolds or traditional cpc paste (control group).

objective: the investigators initiated a pilot clinical study to test safety and preliminary efficacy in humans (bone tissue repairing capacity) and to evaluate standard clinical and rehabilitation protocols. summary background data: bone tissue engineering scaffolds loading growth factors have been considered as the most perspective among all bone substitutes, yet little progress of its clinical translation has been made. the concept of "micro-scaffolds" was proposed in this study to provide a trajectory to its clinical translation. methods: pre-cured cpc/rhbmp-2 micro-scaffolds have been successfully developed and further applied as an easy-to-operate filler for bone regeneration in a pilot clinical study. patients of tibial plateau fractures, proximal humeral fractures, or calcaneal fractures at a similar level of severity were randomly divided into two groups and treated by cpc/rhbmp-2 microffolds or traditional cpc paste (control group).

Eligibility criteria:
inclusion criteria: 1. age 16\~70 years. 2. tibial plateau fractures, proximal humeral fractures, or calcaneal fractures at a similar level of severity. 3. an understanding of the rehabilitation protocol and willing to follow it. 4. an agreement to postoperative visits and tests. 5. signed an informed subject consent form. exclusion criteria: -

Keywords: bone substitute cpc rhbmp-2
relationship between gait variability and sensation

Conditions: Amputation, Traumatic

Summary: twenty individuals who were referred to receive physiotherapy will be participants of the study. participants with lower limb loss will evaluate with the following assessment tools: demographic datas; age, gender, height, body mass, year, side and level of limb loss will be recorded. gait parameters (step length, variation of step length) will evaluate with gait trainer biodex 2, at participant's preferred speed.phantom sensation and phantom pain will be asked as existence or not. sensorial loss will evaluate with semmes weinstein monofilaments

twenty participants with lower limb loss who were referred to receive amputee rehabilitation at hacettepe university, faculty of health sciences, department of physiotherapy and rehabilitation, prosthetics and biomechanics unit, will be the subjects of this study. participants with lower limb loss will evaluate with the following assessment tools: demographic datas; age, gender, height, body mass, year, side and level of limb loss will be recorded. gait parameters (step length, variation of step length) will evaluate with gait trainer biodex 2, at participant's preferred speed. to eliminate the learning effect, participants practiced at treadmill to determine appropriate gait speed. once participants implied the preferred speed, they asked to walk at their self selected speed for 6 minutes. data was recorded between the 2nd and 4th minutes at walk. phantom sensation and phantom pain will be asked as existence or not. sensorial loss will evaluate with semmes weinstein monofilaments.

Eligibility criteria:
inclusion criteria: individuals with unilateral lower limb loss traumatic limb loss age between 20-55 years using conventional type socket design dynamic foot using exclusion criteria: have passive joint limitation at extremities surgery at last 1 year systemic problems such as neurologic disorders, rheumatoid disorders... another orthopedic anomalies

Keywords: limb loss gait variability phantom sensation phantom pain peripheral sensation
harmony tpv post-approval study

Conditions: Congenital Heart Disease; Tetrology of Fallot; RVOT Anomaly; Pulmonary Regurgitation

Summary: the purpose of this study is to characterize the functionality of transcatheter implantation of the medtronic harmony transcatheter pulmonary valve (tpv) achieved by real-world implanters.


Eligibility criteria:
inclusion criteria: * patient eligible to receive the harmony tpv, meeting the indications for use criteria per current geography-specific device labeling at time of study enrollment * patient (or patient's legally authorized representative) is willing to consent to participate in the study exclusion criteria: * obstruction of the central veins * planned concomitant branch pulmonary artery stenting at time of implant * subject is pregnant at time of implant procedure * patients with previously treated with an rv-pa conduit or previously implanted bioprosthesis * a major or progressive non-cardiac disease (e.g. liver failure, renal failure, cancer) that results in a life expectancy of less than one year * planned implantation of the harmony tpv in the left heart * echocardiographic evidence of intracardiac mass, thrombus, or vegetation * pre-existing prosthetic heart valve or prosthetic ring in any position
a retrospective chart review of botox® and xeomin® for the treatment of cervical dystonia and blepharospasm

Conditions: Cervical Dystonia; Blepharospasm

Summary: this study is a retrospective chart review to evaluate the doses of botulinum type a toxins botox® (onabotulinumtoxina) and xeomin® (incobotulinumtoxina) used for the treatment of cervical dystonia and blepharospasm in clinical practice.


Eligibility criteria:
inclusion criteria: * confirmed primary diagnosis of idiopathic cervical dystonia or blepharospasm for at least 2 years * treatment with xeomin® and botox® for at least 1 year each exclusion criteria: * having a neuromuscular junction transmission disorder or taking any medications that could affect neuromuscular junction transmission * previous surgical procedure involving bone or muscle for the management of cervical dystonia or blepharospasm
surgery for esotropia under topical anesthesia

Conditions: Esotropia

Summary: adult patients requiring surgery for esotropia will be randomized to surgery under topical anesthesia or sub-tenon's anesthesia. amount of surgery required with the two anesthetic procedures will be compared. motor and sensory outcome of the two treatment groups will also be compared.


Eligibility criteria:
inclusion criteria: * esotropia deviation angle equal to or lower than 45 prism dioptres (requiring one or two-muscle surgery) * visual acuity at least 20/40 in each eye * cooperation for topical anesthesia exclusion criteria: * paretic or restrictive strabismus * previous eye muscle surgery * significant eye disease other than strabismus
impact of crew resource management training to improve the effectiveness of surgical safety checklist (idilic)

Conditions: Surgery

Summary: this multicenter cluster-randomized trial will evaluate the impact of crew resource management training on the occurrence of postoperative complications and the adherence to a surgical safety checklist, among a large sample of french surgical departments.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years old * hospitalization ≥ 24 hours * available medical file exclusion criteria: * patient refusal

Keywords: crew resource management surgical safety checklist postoperative complications