Kornimate/medical-research-clean huggingface dataset:
ultrapure water system for hemodialysis therapy

Conditions: The Change of Biomarkers CRP, CBC With the Use of Ultra Pure Water System for; Hemodialysis.; The Rate of Adverse Events Such as Hypotension During Hemodialysis Therapy With Ultra Pure Water; System as Compared to Conventional Water System.

Summary: we wish to compare the effect of very clean water used for dialysis therapy (i.e ultrapure water) in comparison with the use of conventional water which are used in most dialysis units worldwide. to the best of our knowledge prospective data in that field is sparse.

in observational studies, the use of very pure dialysis solution has been suggested to reduce the plasma level of crp, il-6 ; to improve the response to anemia to erythropoietin therapy ; to promote better nutrition as evidenced by increase in plasma albumin value , estimated dry body weight, midarm muscle circumference and urea-nitrogen appearance rate; to reduce plasma level of β2-microglobulin and pentosidine ; to dely carpal tunnel syndrome ; to slow the loss of residual renal function; and to lower cardiovascular morbidity.the aim of this study is to prospectively evaluate the effect of dialysis performed with ultra-pure water (upw)in comparison with dialysis with the use of conventional water system. patients enrolled into this study will be evaluated at initial period of one month treated with conventional water system (-30 to 0 days). then water system will be switched to ultra-pure water system with the use of filter added to the dialysis machine (gambro). after switching to upw system the patients will be followed for a period of one year (days 0-365). primary end point will be change in crp. additional parameters: blood pressure, adverse events during dialysis, hemoglobin levels and white-blood cell counts.

Eligibility criteria:
inclusion criteria: 1. chronic hemodialysis therapy thrice weekly \> 3 months of therapy 2. signed an informed consent - exclusion criteria: 1. enrolled to other study 2. ongoing infection -

Keywords: ultrapure water,hemodialysis, crp, blood pressure
pharmacokinetics，safety and efficacy of zsp1273 in children 2-17 years old with influenza a

Conditions: Influenza a

Summary: this trial is conducted in china. the aim of the trial is to investigate safety,pharmacokinetics and pharmacodynamics of zsp1273 granules


Eligibility criteria:
inclusion criteria: 1. subjects and their guardians who are able to understand the study and comply with all study procedures, and willing to provide written informed consent/assent prior to the predose examinations appropriately. 2. male or female subjects aged ≥ 2 to ≤17 years at the time of signing the informed consent form. 3. subjects with a diagnosis of influenza virus infection confirmed by all of the following: * positive rapid antigen test (rat) for influenza with nasal or throat swabs; * the time interval between the onset of symptoms and enrollment is 72 hours or less; * fever ≥ 38ºc (axillary temperature); and at least one following respiratory symptoms associated with influenza virus infection is present exclusion criteria: 1. subjects with severe influenza virus infection； 2. subjects with any medical history in gastrointestinal that interferes with the absorption of drugs； 3. immunodeficiency,including malignant tumor,organ or marrow transplant,human immunodeficiency virus \[hiv\] infection,or patients receiving immunosuppressant therapy 3 months prior to enrollment； 4. have received any other investigational products within 3 months prior to dosing； 5. positive urine pregnancy test； 6. subjects with concurrent infections requiring antimicrobial therapy； 7. subjects who are considered inappropriate for the study by the investigator.
yang yin fu zheng therapy in hbv associated hepatocellular carcinoma

Conditions: Hepatocellular Carcinoma

Summary: clinical research of yang yin fu zheng therapy in hbv associated hepatocellular carcinoma basing on immune microenviroment.the purpose of this study is to observe the efficacy of routine medical care combined with yang yin fu zheng therapy for patients belong to hbv-hcc.


Eligibility criteria:
inclusion criteria: 1. confirmed of stage hbv-hccⅱb、ⅲa、ⅲb; 2. ages eligible for study: ≤75 years old; 3. tcm syndrome is deficiency of both qi and yin; 4. confirmed of chb; 5. surgery cannot be allowed; 6. informed consent from the patient. exclusion criteria: 1. patient with other chronic hepatopathy, such as aih, nafld, ald; 2. serious problem of heart, lung, or kidney with severe dysfunction; 3. pregnant or child breast feeding women; 4. mental or cognitive disorders; 5. participating in other drug trials; 6. who are allergic to the study drug.
interval-training in type 2 diabetics

Conditions: Diabetes Mellitus, Type 2

Summary: interval training is superior to continuous training for improving glycemic control, hereunder glycemic variability and -spikes. however, the underlying mechanisms and the clinical impact is at present unknown. the overall objective of this project is to determine the mechanisms underlying aeroic interval-training-induced reductions in glycemic variability and -spikes, and the impact on levels of systemic inflammation in type 2 diabetes patients. it is hypothesized that aerobic interval training reduces glycemic variability and -spikes more than continuous training due to larger improvements in both peripheral insulin sensitivity and the mass action effect of glucose. moreover, it is hypothesized that these reductions in glycemic variability and -spikes also reduces systemic inflammation.


Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus * bmi \>18 but \<40 kg/m2 exclusion criteria: * pregnancy * smoking * contraindication to increased levels of physical activity * more than moderate levels of physical activity (\>90 min/week) of maximally moderate intensity * insulin dependence * thyroid, liver, lung, heart or kidney disease, with the need for treatment

Keywords: exercise training interval training systemic inflammation glucose disposal insulin sensitivity glucose effectiveness
the effects of progressive relaxation exercise

Conditions: Effects of Progressive Relaxation Exercise; Exercise; Relation, Interpersonal

Summary: aim: this research was conducted to determine the effects of progressive relaxation exercise on life satisfaction, anxiety, and psychological well-being in people experiencing premenstrual syndrome. methods: this randomized controlled trial was conducted with students who were enrolled in a university in the east of türkiye, studying at the undergraduate levels outside the field of health, and experiencing premenstrual syndrome. the sample of the research consisted of 162 students (exercise group 81 participants; control group 81 participants). the personal information form, premenstrual syndrome scale (pmss), life satisfaction scale (lss), beck anxiety scale (bas), and psychological well-being scale (pwbs) were used to collect data. women in the exercise group underwent eight sessions of relaxation exercises, once a week for 8 weeks. in addition, for eight weeks after the first exercise, the participants exercised at home, at least twice a week, outside of the training. the pmss, lss, bas, and pwbs were applied as post-tests to the participants in both groups, 8 weeks after the pre-tests.


Eligibility criteria:
inclusion criteria: * those who scored 111 points or more on the premenstrual syndrome scale, * were married or single at the time of the research, * did not have children. exclusion criteria: * those who were pregnant or postpartum, * those who were diagnosed with any psychiatric disease according to the records, * those who did not perform relaxation exercises outside of the training.
establishment and clinical validation of a new technique for early diagnosis of diabetic nephropathy

Conditions: Diabetes Mellitus; Biomarkers; Diabetic Kidney Disease; Early Diagnosis

Summary: diabetic kidney disease(dkd) is a leading cause of chronic kidney disease and end-stage renal disease across the world. early identification of dkd is vitally important for the effective prevention and control of it. however, the available indicators are doubtful in the early diagnosis of dkd. this study aims to develop a novel system of multidimensional network biomarkers (mdnbs) to estimating early diabetic nephropathy, and further validating the performance of the novel systemin in prediction of the risk for early diabetic nephropathy by a nested case-control study.

patients with a history of more than 5 years of diabetes without dkd were recruited. at the baseline visit, the patients' serum, plasma and urine were collected after obtaining informed patient consent. simultaneously, the basic information, anthropometric indicators (including height, weight, waist circumference, hip circumference, blood pressure), past history, family history, menstrual history, birth history, medication history, lifestyle of the patients were registered, and the corresponding laboratory examination and auxiliary examination were carried out according to the diagnostic process. all data and data were entered into the database for later analysis. after 5years of follow up, subjects will be divided into two groups(the new onset dkd group and the non-dkd group), the base line level of mdnbs were tested in the two group to validate the performance of the novel mdnbs in in prediction of the risk for early diabetic nephropathy.

Eligibility criteria:
inclusion criteria: * subjects who have signed informed consent. * subjects who were diagnosed with diabetes at least 5 years. * subjects showed good compliance, and the follow-up data was available for \>5 years. exclusion criteria: * renal diseases caused by other causes, including primary and secondary; * all kinds of acute infections; * the expected life expectancy (life expectancy or related diseases) was less than 5 years according to the researcher's judgment. * drug users or drug abusers; * sexually transmitted diseases such as viral hepatitis, aids and syphilis, and infectious diseases such as tuberculosis are in an active period; * any situation judged by the researcher that affects enrollment.
a multicenter study on the diagnosis and intervention of new biomarkers on the prodromal stage of alzheimer's disease

Conditions: Alzheimer's Disease

Summary: the prevalence of mild cognitive impairment (mci) is about 15%-17%. 10%-15% of mci progresses to alzheimer's disease (ad) every year. the annual incidence of mci in the normal elderly is about 1%. is the key and difficult points in ad research. except expensive brain β amyloid plaque imaging, few breakthroughs of early diagnosis technology of mci due to ad can be made to facilitate clinical application. the purpose of this program is to study the reliability and validity of plasma mirnas for early diagnosis of mci due to ad. the clinical diagnosis of ad and mci due to ad are according to the national institute of aging and the alzheimer's disease association (nia-aa) diagnostic criteria in 2011. \[18f\]-av-45 plaque imaging is used to be golden criteria for the diagnosis of ad and mci due to ad. next, a pilot intervention study on app/ps1 transgenic mice will be promoted based on mirnas gene regulation.


Eligibility criteria:
inclusion criteria: * 2011 nia-aa criteria of mci due to ad or ad exclusion criteria: * non ad dementia
the effects of pilates training on exercise capacity and respiratory muscle performance in patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: rheumatoid arthritis (ra) is a chronic inflammatory disease associated with significant functional impairment and increased risk for cardiovascular and pulmonary disease. along with pharmacological therapy, exercise seems to be a very promising intervention to improve disease-related outcomes, including functional capacity and systemic manifestations. despite the fact that aerobic and strengthening exercises have been shown to be useful in patients with ra, there have been limited research on the effects of pilates training. therefore, we aimed to investigate the effect of clinical pilates training on exercise capacity, respiratory and peripheral muscle strength, respiratory muscle endurance, respiratory function, pain, balance, core stability, dyspnea, functional status, fatigue, quality of life, depression and anxiety in patients with ra.

according to sample size calculation 30 patients with ra will be included. patients will be evaluated before and after treatment. patients will be randomized into exercise and control training groups. in the exercise training group the patients will be given pilates exercise; in the control training group, the patients will be given relaxation exercise. pilates exercises will be applied by the physiotherapist 3 days a week for 8 weeks. the patients in the control training group will be given relaxation exercises as a home exercise program 3 days a week for 8 weeks. exercise capacity, pulmonary functions, respiratory and peripheral muscle strength, respiratory muscle endurance, pain, balance, core stability, dyspnea, functional status, fatigue, quality of life, depression and anxiety will be evaluated.

Eligibility criteria:
inclusion criteria: * 18-65 years old * being diagnosed according to the american college of rheumatology (acr)/eular 2010 rheumatoid arthritis diagnostic criteria * under standard medications exclusion criteria: * orthopedic or neurological disease with a potential to affect functional capacity * have problems that can prevent evaluation * have a neurological problem that may cause hearing or vision impairment * changes in medical treatment in the last 3 months * have high disease activity score (das-28\>3.2)

Keywords: rheumatoid arthritis respiratory muscle strength respiratory muscle endurance exercise capacity
resuscitative tee collaborative registry

Conditions: Cardiac Arrest; Cardiac Arrest Circulatory; Cardiac Arrest, Out-Of-Hospital; Shock; Hemodynamic Instability

Summary: the general objective of this study is to evaluate the clinical impact and safety of focused, point-of-care transesophageal echocardiography (tee) used during the evaluation of critically-ill patients in the emergency and intensive care settings. the target population for this study are critically-ill patients over the age of 18 who as part of their routine clinical care are receiving a focused tee. the primary objective of this study is to determine the clinical impact and safety of tee performed during the evaluation of critically-ill patients in the emergency department and intensive care settings. the secondary objective(s) of this study are to characterize the use of this imaging modality in the subsets of critically-ill patients in shock and cardiac arrest; including but not limited to; description of the frequency of studies, clinical indications, clinician characteristics, echocardiography findings, timing of studies, procedure-related complications and patient outcomes.

vision the resuscitative tee collaborative registry aims to accelerate the development of outcome-oriented research and knowledge translation on the use of tee in emergency and critical care settings. mission the registry aims to catalyze clinical research involving the use of tee in critically-ill patients through the following strategic initiatives: * facilitate collaboration between different clinical teams and organizations across the entire spectrum of users of tee in acute care setting, including emergency departments and intensive care units. * standardize data collection and reporting that enables multi-institutional data sharing. * provide an efficient research infrastructure that facilitates data capture, management and analysis, enabling teams around the world to conduct research studies in this field. * make shared data open and accessible to clinicians and researchers.

Eligibility criteria:
inclusion criteria: * adult critically-ill patients who as part of their routine clinical care receive focused tee in the emergency department of intensive care setting. exclusion criteria: * children (age under 18 years) * vulnerable populations

Keywords: transesophageal echocardiography resuscitation cardiac arrest point-of-care ultrasound focused cardiac ultrasound
identification of hepatic lesions

Conditions: Hepatic Neoplasms

Summary: patients with suspicion of primary or secondary hepatic malignancy in whom a radiological examination is needed in order to decide on the most appropriate treatment.

the study has previously been posted by schering ag, germany. schering ag, germany has been renamed to bayer schering pharma ag, germany. bayer schering pharma ag, germany is the sponsor of the trial.

Eligibility criteria:
inclusion criteria: 1. present with suspicion of primary or secondary hepatic malignancy in whom a radiological examination is needed in order to decide on the most appropriate treatment. there should not be more than five liver lesions on type visualized on ct. the patient should be in a condition that allows subsequent treatment. 2. be willing and able to continue study participation following administration of sh u 555 a to ensure completion of all procedures and observations required by the trial protocol. 3. sign and date fully informed consent prior to entry into the study. exclusion criteria: * patients under 18 years of age. * patients weighing less than 35 kg. * patients who have received any investigational drug within the 30 days prior to entering this study. * patients who have previously entered this study or any other study performed with sh u 555 a. * women who are pregnant or who are of childbearing potential and have not had a negative urine pregnancy test immediately prior to the administration of sh u 555 a. the urine pregnancy test should be performed in accordance with the manufacturer's recommendations. * lactating women. * patients who have any contraindication to mri examination. * patients who have received any contrast material in the 24 hours prior to sh u 555 a injection, or who are scheduled to receive any contrast material within 24 hours afterwards. (in the case of any liver specific agent (e.g. mndpdp, spios, gd-bopta) this will be extended to 14 days prior to the study). * patients who have received lipiodol contrast material at any time in the past or are scheduled to receive this during the study period. * patients who are clinically unstable and whose clinical course during the observation period is unpredictable (e.g. due to previous surgery). * patients scheduled for liver biopsy within 24 hours, or who had a biopsy within the 24 hours prior to planned sh u 555 a injection. * patients who are scheduled for, or are likely to require, surgery within 24 hours after sh u 555 a injection. * patients with a history of anaphylactoid or anaphylactic reaction to any allergen including drugs and contrast agents. * patients with known hypersensitivity to any of the ingredients of sh u 555 a. * patients with already clear op-indication

Keywords: known or suspected focal liver lesions detected by spiral ct
evaluation of purse-string closure vs second intention

Conditions: Wound Closure Techniques

Summary: to compare healing time, scar size, aesthetic outcome, and complication rates following second intention healing or purse string closure of surgical wounds on the trunk or extremities. this study, will allow surgeons to make informed decisions on whether purse string closure is superior to that of second intention healing and thus worth considering or inferior and not worth performing.


Eligibility criteria:
inclusion criteria: * over 18 years of age * able to give informed consent themselves * willing to return for follow-up visits * post-operative defects greater than 8 mm (in greatest diameter or length of circular or oval geometric shape) on the trunk and extremities (including the shin, hands, and feet) exclusion criteria: * mentally handicapped * unable to understand written and oral english * incarceration * under 18 years of age * unwilling to return for follow-up * pregnant women * wounds less than 8 mm in length * wounds on the head, neck or digits * patients in which primary linear closure is recommended
vestibular nerve stimulation to improve sleep

Conditions: Insomnia; Sleep; Sleep Disorders, Circadian Rhythm

Summary: a randomized, double blind sham controlled clinical trial to evaluate the efficacy of vestibular nerve stimulation (vens) compared to a sham control a as a means of improving sleep as measured by isi scores and eeg recordings the purpose of this investigation device study is to collect data that will be used to design appropriate pivotal studies that can be used for regulatory submissions, primarily in the united states of america (usa), but it may also be used to support submissions in other regions, including the european union (eu).


Eligibility criteria:
inclusion criteria: * adults * both genders * ages 18-24 years inclusive * score above 14 in the insomnia severity index questionnaire * willingness to participate in the study. exclusion criteria: * use sleep medication * ear problems * under any kind of treatment * practicing sleep improving techniques * any other significant health-related problems.
use of medium frequency electrotherapy in the treatment of oab, luts and pelvic pain

Conditions: Urinary Bladder, Overactive; Lower Urinary Tract Symptoms; Pelvic Pain

Summary: the aim of this study is to assess the effectiveness of medium frequency electrotherapy (interferential currents) treatment for overactive bladder (oab), lower urinary tract symptoms (luts) and pelvic pain

this study consists of 100 women, complaining of increased bladder sensation and urgency with or without incontinence as principal symptomatology and who had not received previous pharmacological treatment. group-a was used as a control group (n = 50). group-b patients received 18 sessions of medium frequency electrotherapy during 9 weeks, 2 weekly sessions

Eligibility criteria:
inclusion criteria: increased bladder sensation urgency overactive bladder lower urinary tract symptoms pelvic pain exclusion criteria: neurogenic bladder acute urinary infection pelvic floor surgery congenital urological malformations age less than 18 years bladder organic pathology pelvic radiotherapy

Keywords: urgency frequency overactive bladder luts pelvic pain electrostimulation
cardiac performance system data collection study

Conditions: Cardiac Disease

Summary: non-significant risk device study to conduct evaluation of the performance of new device for monitoring of cardiac function (based on previous iterations 510(k) 173156)

non-significant risk device study to conduct evaluation of the performance of new device for monitoring of cardiac function (based on previous iterations 510(k) 173156)

Eligibility criteria:
inclusion criteria: * ability to provide written informed consent * 22 years of age or older * referred for cardiac catheterization for reasons including heart failure, evaluation before transplant, pulmonary hypertension, shortness of breath, valvular disease, etc. exclusion criteria: * previous heart transplant * presence of left ventricular assist device * presence of a holter monitor or any other electrical leads on the chest at the time of sensor placement * surgical scars/wounds/bandages/ports at the site of sensor placement