Kornimate/medical-research-clean huggingface dataset:
examining techniques on adenoma miss rate in proximal colon

Conditions: Colorectal Adenoma; Colorectal Polyp

Summary: the primary aim of this study is - to explore the usefulness of re-examination and retroflexion on adenoma miss rate (amr) in the proximal colon. other aims include to explore the data below when re-examination or retroflexion is used. * adenoma detection rate, adr * polyp miss rate, pmr * polyp detection rate, pdr * withdrawal time, wt

amr = number of adenomas missing during the first examination/ total number of adenomas in both examinations = number of adenomas detected only in the second examination/(number of adenomas detected during the first examination + number of adenomas detected only in the second examination)

Eligibility criteria:
inclusion criteria: * patients between 45 and 80 years who undergo colonoscopy examination for screening, and who receive primary screening and get positive result exclusion criteria: * pregnant female patients * patients received colonoscopy in the past 5 years * patients who have history of colorectal cancer, colorectal polyposis, inflammatory bowel disease or heredity colorectal neoplasm syndrome such as familiar adenomatous polyposis, lynch syndrome and so on * patients who had previous abdominal surgery * patients who are known to have colonic stricture or obstructing tumor from the results of radiography (x ray, ct scan or barium enema) * patients who are presenting acute surgical conditions such as severe colitis, megacolon and active gastrointestinal bleeding * patients who have inadequate bowel preparation * patients who reject to participate in this study

Keywords: colonoscopy lower gastrointestinal tract re-examination retroflexion
fluciclovine pet/ct in multiple myeloma patients

Conditions: Myeloma, Multiple; PET-CT

Summary: comparison between image findings at aminoacid pet/ct and fdg pet/ct for myeloma patients


Eligibility criteria:
inclusion criteria: * multiple myeloma patients suitable for asct treatment exclusion criteria: * patients with contraindications to asct treatment
a randomized controlled study of postoperative adjuvant chemotherapy of uracil- tegafur (uft) compared with surgery alone (nsas-gc)

Conditions: Gastric Cancer

Summary: this is a controlled study designed to evaluate the efficacy of uft on survival compared with surgery alone. patients will be randomly assigned to receive either surgery alone or surgery followed by uft within 6 weeks after curative resection. to assess treatment response, data on recurrence and survival will be collected for 5 years after enrollment of the last patient. to evaluate safety, data on adverse events will be collected for 16 months after the start of treatment.


Eligibility criteria:
inclusion criteria: * age 20 to 75 * performance status 0 , 1, or 2 (ecog) * hematopoietic wbc ≥ 4,000/mm\^3 platelet ≥ 100,000/mm\^3 * hepatic ast and alt ≤ 2 times upper limit of normal(uln) total bilirubin ≤ 1.5 times uln * renal bun ≤1.5 times uln creatinine ≤ 1.5 times uln exclusion criteria: * prior anticancer treatment

Keywords: stomach cancer
effectiveness of breathing exercises during the second stage of labor

Conditions: Labor Pain

Summary: to determine effectiveness of breathing exercises for pregnant women during the second stage of labor on maternal pain, duration of labor, dyspnea, oxygen saturation (spo2) and the first-minute appearance, pulse, grimace, activity and respiration (apgar) scores

this study is about to determine effectiveness of breathing exercises for pregnant women during the second stage of labor on maternal pain, duration of labor, dyspnea, oxygen saturation spo2 and the first-minute appearance, pulse, grimace, activity and respiration (apgar) scores. two sessions will be given to pregnant women in intervention group. one session breathing exercises training will be given during first stage of labor by the investigator. during training all participants in intervention group will be instructed to perform breathing exercises during the second stage of labor. the main components of breathing exercises during training will be as fellows (a) first, fill your stomach and then your lungs with air while breathing in; (b) feel the expansion in the stomach; (c) make sure the muscles from your stomach to your knee are relaxed, as if you are urinating while breathing out; (d) when there is pain, perform deep abdominal breathing exercises, and take a deep breath in and hold as much as you can; (e) try to push the baby downward; (f) you can do it by holding your breath or breathing out quite slowly from your mouth; (g) the most important point in this stage is that you should not fill up the stomach with air, and you should push downward to deliver the baby; (h) you should continue the pushing until the pain is relieved. the participants will be observed during second stage of labor and their breathing will be monitored. 1. during the second stage of labor maternal labor pain will be assessed by visual analogue scale. 2. duration of second stage of labor will be counted by turning on the stop watch on the start of second stage and it will be stopped at the end when baby will be delivered. 3. dyspnea will be monitored by dyspnea scale after performing breathing exercises during second stage of labor. 4. oxygen saturation will be monitored by pulse oximeter during second stage of labor. 5. apgar score of newborn will be marked in 1st minute after the birth.

Eligibility criteria:
inclusion criteria: * pregnant females * gestational age ranging between 37 and 42 weeks exclusion criteria: women using analgesics or anesthetics, women with clinical instability women with psychiatric disorders

Keywords: labor pain breathing exercises second stage of labor
analgesic efficacy of ultrasound-guided external oblique intercostal plane block versus posterior transversus abdominis plane block in patients undergoing open nephrectomy

Conditions: Postoperative Pain

Summary: renal cell carcinoma (rcc) accounts for 2-3% of all cancers and is a common malignancy of the genitourinary tract. open nephrectomy, performed through midline, subcostal, or flank incisions, remains a standard treatment but often results in significant postoperative pain, leading to respiratory muscle dysfunction, increased pulmonary complications, and prolonged hospital stays. acute surgical pain arises from inflammatory responses, activation of spinal pain pathways, and muscle spasms. while postoperative pain typically improves during recovery, some patients develop chronic postsurgical pain (cpsp), lasting at least two months postoperatively. opioids and epidural analgesia are commonly used for pain control, but their side effects and invasiveness necessitate safer, effective alternatives. ultrasound (us)-guided peripheral nerve and field blocks have become integral to multimodal analgesia. one such technique, the \*\*external oblique intercostal plane block (eoipb)\*\*, was introduced as a modification of fascial plane blocks, targeting anterior and lateral cutaneous nerves (t6-t10). eoipb offers advantages over quadratus lumborum block (qlb) and erector spinae plane block (espb) by being performed in the supine position and providing superior midline analgesia compared to serratus intercostal plane block (sipb). similarly, the transversus abdominis plane (tap) block, particularly the posterior approach, delivers analgesia from t7 to t12 by anesthetizing anterior and lateral cutaneous nerve branches. while case series suggest eoipb may be effective for post-nephrectomy pain, comparative studies between eoipb and posterior tap block in open nephrectomy: aim of the study: to evaluate the postoperative analgesic effects of posterior transversus abdominis plane (tap) block and external oblique intercostal plane block (eoipb) in patients undergoing open nephrectomy under general anesthesia.


Eligibility criteria:
inclusion criteria: * patients whom diagnosed as having renal carcinoma and scheduled for open nephrectomy under general anesthesia. * asa class ii- iii. * age ≥ 18 and ≤ 65 years. * body mass index (bmi) less than 40kg/m2. exclusion criteria: * 1. patient refusal. 2. hepatic and renal insufficiency. 3. unstable cardiovascular or pulmonary disease. 4. history of psychiatric and cognitive disorders. 5. patients with known sensitivity or contraindications to the drug used. 6. patients on regular opioid consumption.
koji product supplementation' s study

Conditions: Sarcopenia

Summary: the present project is to identify the effect of black soy beans koji product supplementation on nutrients absorption and anti-aging effect in elderly.

previous studies show that supplementation of soy protein can effectively increase muscle mass and protein utilization. besides, soy extracts and isoflavones can stimulate muscle growth by activating the anabolic pathway of muscle tubules. black soybean is known to be rich in legume protein and isoflavones.we speculate that black soybean supplementation can improve the nutritional status and muscle mass of elderly people, thereby delaying the deterioration of muscular dystrophy in the elderly. reduce the occurrence of debilitation in the elderly.

Eligibility criteria:
inclusion criteria: * 1-2 items are necessary, 3-5 can match one item 1. age above 65 years 2. oral intake 3. walking speed: ≤ 0.8 m/s (measured by time for a 5-meter usual gait) 4. handgrip strength: men: \<26 kg women: \<18 kg (measured by electronic hand grip dynamometer) 5. calf circumference: men: ≤ 34 cm women: ≤ 33 cm exclusion criteria: 1. participant in a moderate or strenuous exercise 2. unable to walk 3. unable to take in food from the mouth 4. people who can't record or communicate. 5. refuse to accept the 3-day diet record 6. allergic to black soybeans or legumes 7. allergic to egg or milk 8. infected with disease and had to be hospitalized for treatment before 4 weeks of the intervention test start 9. a patient who has been diagnosed with a malignant tumor or has a history of malignancy in the past year. 10. the estimated glomerular filtration rate (egfr) is less than 60 ml/min/1.73 m2 in the past three months. 11. hypothyroidism 12. people who often have symptoms of gastrointestinal upset.

Keywords: protein
myo-inositol plus alpha-lactalbumin in pcos myo-inositol-resistant patients

Conditions: PCOS; Myo-inositol-resistance

Summary: the investigator's aim is to evaluate if the combination of myo-inositol and alpha-lactalbumin can overcome the resistance to myo-inositol in pcos patients

in this study, the investigators expect about 30% of the pcos patients enrolled to be resistant to myo-inositol treatment for ovulation induction, probably due to the presence of malabsorption caused by gut dysbiosis. the most recent evidence proposes dysbiosis and related chronic low-grade inflammation as the new dogma behind pcos pathogenesis. in this regard, the recent findings on alpha-lactalbumin reports its effect in improving the absorption of different nutrients including myo-inositol as well as a crucial factor for reducing inflammation. furthermore, this whey protein is well known for its effect as trophic agent for gastrointestinal flora in infants. for all these reasons, the investigators expect that the treatment with inofolic hp (myo-inositol and alpha-lactalbumin) will get an efficacy 20-25% higher than the treatment with inofolic.

Eligibility criteria:
inclusion criteria: * pocs women diagnosed using the rotterdam criteria exclusion criteria: * amenorrhea (3 months) * other conditions causing ovulatory disorders and/or androgens hyper production such as: hyperprolactinemia, hypothyroidism, adrenal hyperplasia and cushing syndrome * hormonal and/or pharmacological treatments in the previous 3 months that could interfere with ovulation * drastic changes in diet * treatment with product containing myo-inositol in the previous 3 months

Keywords: myo-inositol alpha-lactalbumin polycystic ovary syndrome anovulation infertility
artus mono artificial urinary sphincter

Conditions: Urinary Incontinence,Stress

Summary: the artus mono implant is an active implantable medical device (aimd) that assist the urethral sphincter function of female patients suffering from moderate to severe urinary incontinence, by remotely opening and closing a cuff placed around the bladder neck. the purpose of this clinical investigation is to evaluate the feasibility of implantation of the device, its safety and its efficacy, when temporarily implanted in female patients scheduled for anterior pelvic exenteration for bladder cancer.


Eligibility criteria:
inclusion criteria: 1. female patients aged ≥ 18 yo 2. bmi \> 18,5 and \< 35 3. patient scheduled for an anterior pelvic exenteration with ileal conduit urinary diversion 4. signed informed consent exclusion criteria: 1. advanced bladder cancer with bladder neck and/or urethral extension 2. past pelvic radiation therapy 3. patient previously treated with an artificial urinary sphincter or other urogenital implant 4. positive urine culture during the past 2 weeks 5. indwelling bladder catheter during the past 2 weeks 6. documented history of sensitivity to silicone 7. history of connectivitis disease 8. immunosuppressive therapy in the last 3 months 9. vulnerable subjects 10. participation in any other clinical investigation

Keywords: aus artificial urinary sphincter
sh dr. chen gastric bypass study

Conditions: Gastric Bypass

Summary: evaluation of serum gastrin levels and their effect on marginal ulcer formation.

prospective, randomized, interventional trial. participants will be randomized to one of two surgical techniques, either with transection of the vagal nerves, or without. outcomes including compare marginal ulcer rates will be compared using serum gastrin levels before and after surgery and gastric ph during surgery.

Eligibility criteria:
inclusion criteria: * age 18 years and older * diagnosis of obesity or disorder of metabolism undergoing routine gastric bypass surgical intervention * capable of giving signed informed consent. exclusion criteria: * under 18 years of age * ineligible for gastric bypass surgery * pregnant women or women actively seeking to become pregnant.
low-cost and reusable thermal jacket for managing preterm or low birth weight neonates.

Conditions: Preterm; Low Birthweight; Hypothermia Neonatal

Summary: globally, over 15 million neonates are born preterm each year. they account for approximately 30% of global neonatal deaths and 19% of total neonatal deaths in bangladesh. they usually die because they cannot maintain normal temperature due to their weight, immature skin and underdeveloped thermal regulatory capacity of the brain. maintaining continuous kmc for at least 16-20 hours/day, is sometimes not feasible for mothers or caregivers. in addition, we also have the challenge of keeping preterm or lbw neonates warm during transportation. the scientists at icddr,b, johns hopkins university, and george mason university developed the re-usable thermal jacket for keeping preterm or low-birth-weight neonate warm. we propose to build on previous work by systematically testing the safety of the 'thermal jacket' among preterm or low birthweight (lbw) neonates. objective of this study is to conduct clinical safety trial of the thermal jacket to test whether the thermal jacket can retain euthermia of preterm or lbw neonates for 2 hours.

we will equip a single arm trial with no control group design, in which every enrolled neonate will get the experimental therapy (thermal jacket) for this phase. a thermal jacket trial on a preterm or lbw neonate will be considered an event. an event will be considered a success if the neonate can maintain the body temperature in the euthermic range (36.5°c-37.5°c) using the thermal jacket for two hours. thus, the failure event will be if the thermal jacket fails to maintain euthermia for neonates for two hours. suppose, the neonate's body temperature drops below 36.5°c or rises above 37.5°c, the neonate will be monitored for maximum 5 minutes. if not recovered from the state, the neonate then immediately will be removed from the event for the appropriate management under the study's responsibility.

Eligibility criteria:
inclusion criteria: 1. neonate aged between 0-72 hours 2. birthweight between 1800g to 2000g 3. no gross congenital anomaly 4. normal heart 100-160 per minute 5. capillary refill time ≤3 sec 6. respiratory rate 30-59 per minute 7. breaths comfortably (no chest indrawing, no gasping) 8. no sign of respiratory distress (respiratory rate within normal limit) 9. pink in room air (without oxygen therapy) 10. h/o no prolonged or frequent apnea \& no visible apnea during study enrolment 11. no major surgical problem exclusion criteria: 1. in nasogastric tube 2. in oxygen therapy 3. in intravenous fluid

Keywords: preterm neonate low birthweight neonate kangaroo mother care thermal jacket safety trial
safety and efficacy of curcumin in children with acute lymphoblastic leukemia

Conditions: Acute Lymphoblastic Leukemia, Pediatric

Summary: assessment of of the biological effects of curcumin on microbiota in children with acute lymphoblastic leukemia

assessment of the safety of curcumin, which is the most active constituent of the ground rhizome of the curcuma longa plant, in children with acute lymphoblastic leukemia patients (all) in maintenance phase of chemotherapy through the assessment of the any reported adverse event (ae). and assessment of the curcumin effect on health by eliminating intestinal microflora dysbiosis

Eligibility criteria:
inclusion criteria: children aged from 1 year to 18 years children with proven all diagnosed by bone marrow aspirate and immunephenotyping patients in the maintenance phase week1 exclusion criteria: children with other maliganacies, current use (past use of these medications is not an exclusion) of medications or over-the-counter treatments including to sulfasalazine, warfarin, clopidogrel, aspirin, antacids, botanical treatments (ginger, feverfew, yellow clover, salix species, populus species, betula species, and gaultheria species), essential fatty acids (flax oil and fish oil).

Keywords: curcumin ain shams university egypt acute lymphoblastic leukemia children
inhalatorial sedation in patient with subarachnoid hemorrhage (sah) versus conventional intravenous sedation

Conditions: Stroke; Subarachnoid Hemorrhage

Summary: recent study has shown that inhalatory sedation is a practicable, effective and not risky method in intensive care unit. sevoflurane effect on cerebral system have been described in previous studies: it causes an increasing of cerebral blood flow and a decrease of oxygen cerebral consumption. clinical strategy for subarachnoid hemorrhage is orientated to increase cerebral blood flow to limit vasospasm phenomena after sah. scope of this study is to evaluate the cerebral blood flow variation associated to isoflurane sedation versus conventional sedation with propofol .


Eligibility criteria:
inclusion criteria: * diagnosis of asah * indication to dve positioning * clinical indication to sedation and assisted ventilation * indication to icp and cbf monitoring * age \> 18 exclusion criteria: * documented cranial hypertension (icp\>18) not controller by liquor drainage * age \< 18.

Keywords: sah sedation anesthesia
rehabilitation - physical activity and coping

Conditions: Cancer Survivors

Summary: the project is a non-randomized intervention study with group-based physical exercise. cancer survivors who have participated in the rehabilitation program at the center for education and rehabilitation are included in the study. the cancer and cancer treatment have led to patients struggling with physical, mental and social late effects which prevent them from functioning in everyday life and return to work. the purpose of the project is to investigate whether one municipal group training measure can help to lower the threshold for the user to maintain good exercise habits and return to work / everyday life, as well as the effect on the user's physical form and quality of life and the transition between health level and the body itself measure.


Eligibility criteria:
inclusion criteria: * 18 years * women and men * regardless of cancer diagnosis * resident in bergen municipality * finishes their rehabilitation at the cancer center for education and rehabilitation spring/summer 2019. exclusion criteria: * patients who do not speak or understand norwegian * unable to express themselves in writing * unable to perform basic daily tasks * display cognitive disorder or severe emotional instability * suffer from other debilitating illnesses / conditions that may inhibit physical exercise (heart failure, chronic obstructive pulmonary disease, orthopedic conditions, neurological disorders or the like) will be excluded from the study. -

Keywords: rehabilitation physical exercise return to work fatigue cancer survivors
dabigatran in patients with atrial fibrillation and mitral biological prostheses

Conditions: Mitral Valve Stenosis and Insufficiency; Atrial Fibrillation

Summary: the efficacy and safety of anticoagulation therapy using dabigatran in comparison with warfarin will be evaluated in patients with atrial fibrillation after mitral valve prosthetic replacement concomitant with cox-maze procedure.

patients with prosthetic mitral valves need a long-term anticoagulation therapy. after mitral valve replacement using mechanical prostheses warfarin is administrated during the whole life. biological prostheses allows do discontinue anticoagulation 3 months after surgery in the absence of other risk factors of thrombosis especially atrial fibrillation. the common approach to patients with mitral valve disease and atrial fibrillation is mitral valve prosthetic replacement concomitant to cox-maze procedure. this allows to maintain sinus rhythm in 65-80% of patients. in the study the safety and efficacy of dabigatran in comparison with warfarin will be evaluated after the mitral valve surgery and cox-maze procedure.

Eligibility criteria:
inclusion criteria: * mitral valve disease; * atrial fibrillation; * mitral valve prosthetic replacement with concomitant cox-maze procedure; * 18-75 years of age; * signed informed consent form. exclusion criteria: * mechanical valve replacement; * repeated mitral valve surgery; * coronary artery hemodynamically significant stenoses; * ventricular arrhythmias; * creatinine clearance \<50 ml/min; * has-bled score \>3; * previous stroke or transient ischemic attack; * liver diseases; * neoplasia; * pregnancy; * simultaneous antiplatelet therapy; * allergic reactions on dabigatran or warfarin; * cognitive disorders.

Keywords: atrial fibrillation mitral valve stenosis mitral valve insufficiency dabigatran biological prosthesis mitral valve replacement cox-maze procedure
non-motor symptoms and brain dopamine transporter binding

Conditions: Parkinson Disease; Parkinsonism

Summary: this project aims to clarify the role non-motor symptoms in the development of parkinson's disease (pd) and to improve diagnostics at very early stages of pd. the project involves multidimensional measures of disease biomarkers together with brain dopamine transporter (dat) imaging with \[123i\]fp-cit single photon emission computed tomography (spect).


Eligibility criteria:
inclusion criteria: * male or female * age 18-100 years * referred for clinical dat spect in turku or helsinki

Keywords: parkinsonism dat dopamine transporter spect