Kornimate/medical-research-clean huggingface dataset:
the efficency and safety of stretta in gerd

Conditions: GERD; Radiofrequency Ablation

Summary: this study evaluated the efficency and safety of the endoscopic radiofrequency procedure(stretta) in adult gastroesophageal patients.

gastro-esophageal reflux disease (gerd) is the most common outpatient diagnosis in gastroenterology and is associated with a significant burden on the healthcare system. proton pump inhibitors (ppis) are the mainstay of gerd treatment,howerver, some patients have an unsatisfactory response to high doses of ppis, which remains a challenge. the stretta procedure, a radiofrequency (rf) application to the lower esophageal sphincter (les), was introduced about 15 years ago as an alternative to chronic medical therapy or surgical intervention for gerd.the stretta procedure appears to result in thickening of the les, decreased transient les relaxation rate and reduced esophageal acid exposure.the majority studies of stretta were held in usa and europe, the sduty of stretta in asia is rare. the investigators propose to perform a prospectively observiton study to evaluate the efficency of the stretta procedure in patients of refractory gerd in china.

Eligibility criteria:
inclusion criteria: 1. age \> 18 years 2. small hiatus hernia (\< 2-3 cm) 3. los angeles grade 'a' or 'b' reflux esophagitis or non erosive esophagitis 4. les pressure \<15 mm hg 5. ppi dependent / refractory gerd 6. abnormal 24h esophagus ph-impedance monitoring exclusion criteria: 1. age \< 18 years 2. large hiatus hernia (\> 3 cm) 3. los angeles grade 'c' or 'd' reflux esophagitis 4. les pressure \> 15 mm hg 5. underlying coagulation disorder 6. previous esophageal or gastric surgery 7. pregnant 8. major esophagus motility disorder according to chicago v3.0

Keywords: gerd radiofrequency ablation efficiency safety
efficacy of ivabradine in patient with both persistent atrial fibrillation and heart failure with reduce ejection fraction

Conditions: Atrial Fibrillation; Ivabradine; Heart Failure

Summary: atrial fibrillation (af) is the most common arrhythmia encountered in clinical practice. previous studies have shown that rate control strategy in af is non-inferior to rhythm control strategy, in terms of stroke and mortality risk. in addition, rate control strategy is associated with lower risk of hospitalization and non-cardiovascular mortality. therefore, rate control is an essential strategy to improve quality of life, decrease morbidity and prevent tachycardia-induced cardiomyopathy in af patients. the recommended rate control agents include beta-blocker, nondihydropyridine calcium-channel blocker (ccb), digoxin and amiodarone. however, in heart failure with reduced ejection fraction patient, the medication of rate control were beta-blocker than digoxin. but several clinical observation study show excess mortality in af patients. ivabradine, a if inhibitor, it is well-established that a pacemaker current, if current, is functionally expressed in the sinus node . previous studies have shown that ivabradine, if inhibitor, significantly reduces sinus rate and improves prognosis in patients with systolic heart failure. interestingly, several investigators found that hyperpolarization- activated cyclic nucleotidylated channel 4 current (hcn4), the main isoform of the channel responsible for if current, is also functionally expressed in the atrioventricular node(av node). recent data have shown that inhibition of if current slows av node conduction in animals and humans. thus, we want to compare the effect of ivabradine on ventricular rate with digoxin in this study.


Eligibility criteria:
inclusion criteria: 1. the patient with persistent or permanent atrial fibrillation(24hr ecg) with hfref and hfmref. 2. after maximal tolerance dose beta-blocker(bisoprolol 20mg/day，carvedilol 50mg/day) or intolerant to beta-blocker the resting heart rate from ecg is still faster than 100 or resting heart rate from ecg is greater than 80 but still with symptoms of short of breath and palpitation. 3. stable heart rhythm medication.(no change of medication in recently one week) 4. age 20 to 90 years old. 5. the subject must be an adult who can read himself/herself and walk independently. exclusion criteria: 1. used medication with interaction with digoxin : clarithromycin, erythromycin, azithromycin, ritonavir, lopinavir/ritonavir, doxycycline, minocycline, tetracycline。 2. used medication with interaction with ivabradine: voriconazole, posaconazole, fluconazole, ombitasvir, dasabuvir, carbamazepine, enzalutamide, fosphenytoin, mitotane, phenobarbital, phenytoin, rifampicin 3. cardiogenic shock. 4. history of symptomatic bradycardia. 5. renal insufficiency:egfr\<30 ml/min/1.73m2 6. pregnancy 7. heart failure due to congenital heart 8. severe hypotension(\<90/50mmhg)
status epilepticus in the critically ill patients

Conditions: Status Epilepticus

Summary: convulsive and non convulsive status epilepticus (se) and pseudo status epilepticus prospective registry. data collection using a standardized form : demographic data and data related to the se, including circumstances of onset, dates and times of onset and of seizure control, on-scene clinical findings, clinical features of the seizures, pre-hospital and hospital care providers, timing of antiepileptic and supportive treatments, results of etiological investigations, cause of se, type and dosage of antiepileptic drugs. dates and times of eeg monitoring, eeg results. outcomes including vital status and glasgow outcome scale score at icu and hospital discharge, day-90 and 1-year after se and determined based on data in the icu and/or neurologist charts and/or patients phone interview.


Eligibility criteria:
inclusion criteria: * se defined as 5 min or more of (i) continuous clinical and/or electrographic seizure activity or (ii) recurrent seizure activity without recovery (returning to baseline) between seizures. * age \>= 18 years exclusion criteria: * age \< 18 years * postanoxic status epilepticus
limitations of using a sheimpflug image-based device for measuring anterior chamber depth in pseudophakic eyes

Conditions: Cataract

Summary: there have been numerous studies comparing various acd measurements in phakic eyes,while researches comparing acd in pseudophakic eyes are less extensive. with the recent popularity of presbyopia correction, measuring the acd will facilitate differentiating pseudophakic accommodation from pseudoaccommodation. it is thus mandatory to verify the accuracy of acd measurement of these devices since the innovation of various iols in the recent decade makes this task more complicated. in this study, we will assess the limitations of using pentacam for acd measurement in pseudophakic eyes and compare pentacam measurement with iolmaster and a-scan measurements.

in this prospective study, acd was measured in 90 phakic and 94 pseudophakic eyes by pentacam, iolmaster and a-scan. correlations and differences between the three measurements were investigated. the accuracy in detecting the anterior lens surface in pseudophakic eyes was also assessed.differences in acd-pen, acd-iolm, and acd-a were analyzed using one-way analysis of variance (anova). when an overall significance of p\< 0.05 was obtained, pair-wise comparisons were made using tukey's multiple comparison t tests. the association between acd-pen, acd-iolm, and acd-a was assessed using pearson's correlation test. the distribution of erroneous acd-pen measurement for the three iols was analyzed with the chi-square test. in all analyses, p \<0.05 was considered statistically significant.

Eligibility criteria:
inclusion criteria: * phakic group: randomized * pseudophakic eyes : the cases accepted cataract surgery exclusion criteria: * previous ocular trauma or intraocular surgery other than cataract surgery; * contact lens use in the past two months; * use of medication that might affect the pupil; corneal disease or ocular infection; * history of ocular disease, such as * dry eye syndrome * uveitis * glaucoma * ocular tumor * cases with any surgical complications were also excluded.

Keywords: pseudophakic anterior chamber depth pentacam
neuropsychological outcomes of internationally-adopted children who are perinatally-infected with human immunodeficiency virus

Conditions: HIV/AIDS

Summary: children who are perinatally-infected with hiv are extremely vulnerable to cognitive delays and psychiatric disease, and the risk for neuropsychiatric illness is compounded in children who are internationally-adopted and may have suffered trauma, abandonment, malnutrition and neglect. while cognitive and psychiatric issues have been described in hiv-infected children, and even more so in hiv-positive adults, there have been no reports on neuropsychiatric interventions that can improve cognitive and psychiatric states in this highly vulnerable population. without these needed data, pediatric hiv providers have not been able to advocate for optimal neuropsychiatric care in perinatally hiv-infected children, let alone those who has suffered the additional risk of being internationally adopted. in the proposed study, the investigators will report on the neuropsychological profiles and outcomes in a cohort of internationally-adopted, perinatally hiv-infected children between ages 6 to 16 years who have not previously undergone neuropsychological testing or treatment. data obtained from this study will provide important contributions to the literature by building understanding of the complex needs of this population as well as guiding future intervention efforts. the investigators predict that intervention efforts aimed at helping educators understand the learning and cognitive challenges for many of our patients will guide targeted academic supports in the school setting and lead to gains in academic skills. the detailed information obtained during the comprehensive neuropsychological assessment and follow-up care will be shared with the child's key educators at school so that individualized educational strategies can be developed, while maintaining confidentiality regarding the child's hiv status.


Eligibility criteria:
inclusion criteria: * perinatally infected with hiv, internationally adopted exclusion criteria: * prior neuropsychological testing

Keywords: neuropsychological outcomes hiv/aids international adoption perinatal infection
clinical value of dwi-adc matching in the short-term prognosis of wilson's disease

Conditions: Hepatolenticular Degeneration; Wilson

Summary: in earlier studies, it was found that patients of wilson disease with new diagnosed who only has neurological symptoms often had dwi hyper-intensity in brain mri, which was more common in putamen and midbrain, indicating that the disease was in the acute stage. however, many patients had adc hyper-intensity or hypo-intensity at the same time, and the two different signals represented different disease processes from an imaging perspective. the former indicating t2 penetration effect, and the latter represents diffusion limitation, which indicating the presence of local inflammation, edema, etc. whether the signal changes of these two different matching modes have guiding significance for the early de-copper treatment for wd, one is the core point of our study. we hope to exploring the predictive value about dwi-acd signal matching for symptoms changes in the earlier time of de-copper treatment through this study.


Eligibility criteria:
inclusion criteria: 1. patients had been previously diagnosed with wd who both had dwi hyper-intensity and adc hyper-intensity or hypo-intensity at the same time； 2. patients who accept de-copper treatment in hospitalization for 4 weeks or more. exclusion criteria: 1. patients who only with liver injury; 2. severe complications; 3. combined with other diseases.

Keywords: dwi-adc matching wilson disease clinical value short-term prognosis
effect of tocilizumab on intensive care patients with covid-19 pneumonia, a retrospective cohort study

Conditions: Tocilizumab; COVID-19; Critical Care; Mortality

Summary: although its safety and efficacy in the covid-19 patient population are still unclear, tocilizumab is one of treatment. tocilizumab is a u.s. food and drug administration approved il-6 receptor antagonist widely used to treat crs secondary to the chimeric antigen receptor t cell. in this study the investigators will evaluate the efficacy of tocilizumab, an il-6 antagonist administered in the early period in intensive care patients with covid-19 pneumonia followed by hypoxic and systemic inflammation is predominant, but who do not support mechanical ventilation.

with this study, the investigators will evaluate the efficacy of tocilizumab, an il-6 antagonist administered in the early period in intensive care patients with covid-19 pneumonia followed by hypoxic and systemic inflammation is predominant, but who do not support mechanical ventilation. with this study, those with signs of hypoxia and systemic inflammation followed by covid-19 pneumonia (spo2 \<90% on room air together with the elevation of any two of the systemic inflammatory markers such as crp, ldh and ferritin) and / or acute bilateral infiltrates on chest radiograph and tocilizumab the patients who received treatment and those who received standard therapy will be compared. in the study, cases followed up with covid-19 pneumonia and respiratory failure between march 2020 and march 2021 will be retrospectively evaluated. tocilizumab was applied as 400 mg - 800 mg iv (depending on weight). a second dose could be given 12-24 h later if the patient's condition had not improved. primary end point was determined as intensive care mortality.

Eligibility criteria:
inclusion criteria: * all patients were admitted to intensive care unit, diagnosed with covid-19 pneumonia exclusion criteria: * patients who require mechanical ventilation in intensive care admission * cases who received tocilizumab after being intubated during follow-up even though they were not intubated at admission * patients for whom tocilizumab is contraindicated

Keywords: tocilizumab covid-19 critical care mortality
developing self-management interventions after hct

Conditions: Hematopoietic Stem Cell Transplant (HSCT)

Summary: this is a prospective, longitudinal, observational trial to evaluate quality of life in hematopoietic stem cell transplant survivors.

hematopoietic stem cell transplant (hsct) survival rates continue to increase as treatment protocols improve. however, hsct survivors face many mental, emotional, and physical challenges that threaten quality of life (qol), which, according to the american society of clinical oncology, is the most important treatment outcome next to survival. psychoneurologic symptoms (pns) significantly diminish qol after hsct. pns often co-occur and may be associated with inflammation related to perturbations of the gut microbiota. this project will track the interplay among these factors in 50 adult survivors of hsct to lay the groundwork for a targeted dietary self-management intervention to mitigate pn symptoms.this is to be achieved by elucidating the complex bio-behavioral mechanisms of distressing symptoms in hct patients such as neurocognitive dysfunction, fatigue, anxiety, depression and pain, inflammation (cytokines and c-reactive protein), gut microbiota \[(gm) richness and diversity\] and diet (macronutrients: carbohydrates, fats and proteins).

Eligibility criteria:
inclusion criteria: * patients scheduled for hsct with the bone marrow transplant program at the uf health cancer center (ufhcc) \[specifically bone marrow diseases, myelodysplastic-myeloproliferative diseases, lymphoma, bone marrow neoplasm or leukemia\] * written informed consent obtained from the subject to take mini-mental state examination (mmse) prior to enrollment on the study and to comply with all the study-related procedures. * score at least a 24 on the mini-mental state examination (mmse) prior to enrollment exclusion criteria: * subjects with any of the following will not be eligible for study participation: * patient has prior history of hsct * patient has diagnosis that could interfere with neurocognitive function such as dementia, a concurrent diagnosis of systemic lupus erythematous or multiple sclerosis, diagnosis of a major depressive disorder, schizophrenia or untreated bipolar disease. * pregnant women are not eligible for transplant therefore will not be enrolled on the study * inability to comply with the study and/or follow-up procedures.

Keywords: psychoneurological symptoms (pns) quality of life (qol) hematopoietic stem cell transplant (hsct) microbiota gut-brain axis inflammation
the effect of whole body vibration training on neuromuscular property in individuals with ataxia

Conditions: Spinocerebellar Ataxia

Summary: the cerebellum contains ten percent of the total volume of the brain and receives brain, spinal cord and vestibular sensory input. the organization of vestibular and somato-sensory afferent informations are also reported to be impaired in patients with cerebellum dysfunctions. ataxia and impaired balance control are common symptoms in individuals with spinocerebellar ataxia (sca). previous studies have shown that patient with cerebellar damage are usually agonist and antagonist muscle coordination problem. past studies also found the regulation of reciprocal ia inhibition was impaired in patients with spinaocerebellar ataxia. in chronic phase, weakness might be developed due to deconditioned. all deficits mentioned above might lead to a decrease functional ability. therefore, increasing somato-sensory and vestibular input, normalizing the modulation of recriprocal inhibition, and improve muscle strength might be able to improve the functional abilities of individuals with sca. recently, whole body vibration (wbv) has been trained for health groups. studies showed that wbv training were able to improve muscle strength, balance control, and functional ability. however, there is no evidence showed that whether the whole body vibration training can affect the brain and spinal cord for the regulation of neural circuits. whether also can affect for maximal voluntary contraction and improve central fatigue. no previous studies that whole body vibration training for sca. therefore, the purpose of this research was to investigate the intracortical facilitation and inhibition, reciprocal ia inhibition, low frequency depression, maximal voluntary contraction, interpolated twitch technique to compare the different between the sca and health subject. also to investigate the short term and long term effect of wbv.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of spinocerebellar ataxia

Keywords: whole body vibration reciprocal inhibition spinocerebellar ataxia voluntary activation level
punch trabeculectomy versus classic trabeculectomy

Conditions: Glaucoma, Open-Angle

Summary: bleb failure is reduced with punch trabeculectomy procedure. wide sclerostomy during surgery is wanted but controllable. this can be done with single securing suture, releasable sutures and topical intraoperative mitomycin-c. average iop without fluctuation (risk factor) can protect the optic nerve.

this is a prospective randomized study. patients had uncontrolled glaucoma on maximum tolerated medical therapy including acetazolamide tablets were enrolled in this clinical trial and were randomized to tight flap technique group (group a) and loose flap technique group(group b). randomization assigned 40 patients to group a and 40 patients to do group b. a total of 80 patients were enrolled in the study between 2012 and 2014. during trabeculectomy, trabecular meshwork and scleral lamellae were excised made an opening with the kelly scleral punch 1.0 mm 3-5 bites. at 12 o'clock 10/0 nylon monofilament stitch was used to close the apex of triangular scleral flap tightly and two releasable stitches were used at the sides of triangular scleral flap in group a. fig-1 at 12 o'clock 10/0 nylon monofilament stitch was used to secure the edges of the flap at the apex of and two-four releasable stitches were used at the sides of triangular scleral flap in group b. the intraocular pressure and bleb morphology were followed for one year after surgery.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of primary open-angle glaucoma * clinical diagnosis of pigmentary glaucoma * clinical diagnosis of pseudophakic glaucoma exclusion criteria: * high risk factors for failed trabeculectomy must be present e.g. previous failed trabeculectomy surgery and active intraocular infection/ inflammation. * clinical diagnosis of aphakic glaucoma was excluded. * clinical diagnosis of glaucoma with previous ocular incisional surgery (except for clear cornea cataract surgery) were excluded.
effects of smartphone use on posture, pain, function and qol

Conditions: Postural; Defect; Neck Pain, Posterior; Shoulder Pain; Quality of Life

Summary: the aim of the study is to determine the effects of the use of smartphone on the neck and shoulder posture, pain, and functions, and the quality of life in young adults. the sample of the study consists of university students. according to the scores they got from the smartphone addiction scale-short version, all participants will be divided into two groups. the neck and shoulder posture, pain, and functions, and the quality of life will be compared between the two groups.

the study will include 106 university students who are 18-25 years old. according to the scores they got from the smartphone addiction scale-short version, all students will be divided into two groups as excessive smartphone use group and non-excessive smartphone use group, both consisting of 53 participants. participants whose scores are higher than 30 will be included to the excessive smartphone use group, and whose scores are 30 or less will be included to the non-excessive smartphone use group. in the assessment of pain level, the visual analogue scale will be used. functional levels of the neck and shoulders will be evaluated with the copenhagen neck functional disability scale and the shoulder disability questionnaire. world health organization quality of life instrument-short form will be utilized to assess the quality of life. postural analyzes of the participants will be fulfilled with the new york posture rating chart. all scores will be evaluated by comparing between the two groups.

Eligibility criteria:
inclusion criteria: * to be willing and volunteer to participate in the study * to be between 18 and 25 years old * to have been using smartphone for more than 1 year exclusion criteria: * to have any health problem history or diagnosed pathology related with the neck or shoulder regions * to have any history of trauma or surgery related to the neck or shoulder regions * to have received any medical attention or treatment in the last six months because of a health problem related to neck or shoulder * to have any diagnosed neurological problem

Keywords: smartphone addiction forward head posture rounded shoulder neck pain shoulder pain quality of life