Kornimate/medical-research-clean huggingface dataset:
omitting ctv for locally advanced nsclc responded to immunotherapy and chemotherapy

Conditions: Non Small Cell Lung Cancer; Locally Advanced; Radiotherapy; Immunotherapy

Summary: radical radiotherapy is critical for locally advanced non small cell lung cancer(nsclc ). our previous sturdy indicated that patients who received induction immunotherapy and subsequent radiotherapy suffered higher proportion of pneumonitis.grade 2 or more pneumonitis patients have worse prognosis. it is urged to optimize the radiotherapy dose and target volume for patients treated with immunotherapy and radiotherapy. according to retrospective and prospective studies, omitting ctv radiation is feasible for patients undergoing concurrent radio-chemotherapy for locally advanced nsclc. it is postulated that omitting ctv radiation for patients responded to induction therapy with immunotherapy and chemotherapy will have less pneumonitis without sacrificing the local control rate. omitting ctv may also retain better immune function which will facilitate the immunotherapy.


Eligibility criteria:
inclusion criteria: 1. histologically or cytologically confirmed non-small cell lung cancer; 2. stage iiia or iiib or iiic according to the 8th edition of the tnm cancer staging system of the american joint committee on cancer (ajcc) and union for international cancer control（uicc); 3. inoperable or refuses surgery after induction therapy with immunotherapy and chemoradiotherapy; 4. after ≥2 cycles of induction chemotherapy combined with immunotherapy, the efficacy was cr, pr or sd (with a decreasing trend); 5. performance status 0-1; 6. measurable or evaluable lesions; 7. survival expectancy is not less than 6 months; 8. adequate cardiac, pulmonary, renal, and hepatic and bone marrow function exclusion criteria: 1. tumor progress after induction with immunothearoy and chemotherapy 2. egfr, alk, or ros1 mutation; 3. previous thoracic radiotherapy; 4. grade 2 or more immune-related adverse events after induction immunotherapy 5. previous malignancies (except stage i non-melanic skin cancer or cervical carcinoma in situ); 6. pregnant or lactating women 7. undergoing other clinical trials; 8. have serious comorbidities, including myocardial infarction, severe arrhythmia, severe cerebrovascular disease, ulcer disease, psychosis and uncontrollable diabetes; 9. patients with hiv positive and undergoing antiviral therapy; 10. active tuberculosis

Keywords: omitting ctv
comparison of efficacy between combination of amitriptyline-propranolol and pizotifen for migraine prophylaxis.

Conditions: Migraine

Summary: the goal of this clinical trial is to compare efficacy and observe common adverse effects of a combination of amitriptyline-propranolol and pizotifen as prophylactic treatments for migraine. the main question it aims to answer is: • does pizotifen more effective than the combination of amitriptyline-propranolol in migraine prophylaxis? participants will be asked to : * maintain the provided headache diary accordingly * take supplied drugs as described during clinical visits * contact principle investigator if there is any issues regarding drug use and/or their adverse effects


Eligibility criteria:
inclusion criteria: 1. patient of migraine (with typical aura or without aura) according to ichd-3 (international classification of headache disorder, 3rd edition) criteria. 2. age at entry: 18 to 50 years (to minimize the risks related to adverse effects of study drugs such as drowsiness, weight gain, a-v conduction block, postural hypotension) 3. patients not on any prophylactic medications. 4. patients willing to take part in the study. 5. patients being able to fill a headache diary successfully \& reliably. exclusion criteria: 1. age \ 50 years 2. patients having headache other than migraine, complicated migraine, ophthalmoplegic migraine, catamenial migraine, basilar migraine. 3. patients on prophylactic medication. 4. co-morbidities such as heart failure, hepatic or renal impairment, diabetes, bronchial asthma, malignancy, intracranial vascular aneurysm, pregnancy \& breastfeeding etc. 5. patients having known hypersensitivity to amitriptyline, propranolol or pizotifen
role of sweetness in glucose regulation

Conditions: Obesity

Summary: data from several studies show that consuming a diet high in low-calorie sweeteners (lcs), mainly in diet sodas, is linked to the same metabolic disorders as consuming a diet high in added sugars, including an increased risk of developing type 2 diabetes. sweet taste receptors, once thought to be unique to the mouth, have now been discovered in other parts of the body, including the intestine and the pancreas, where they play a role in blood sugar control. these newly identified receptors provide new avenues to explore how lcs may affect metabolism and health. this project is designed to examine the role of sweet taste signaling, both in the mouth and in the gut, on blood sugar control and how habitual consumption of lcs may affect sweet taste signaling and metabolism in people with obesity.

the overall goal of this research is to assess the role of oral and gut sweetness signaling in postprandial glucose metabolism and to determine how acute and chronic low-calorie sweetener (lcs) consumption may affect this signaling in people with obesity. the aims will determine the independent and combined contributions of pharmacological inhibition (aim 1) or extra stimulation (aim 2) of sweet taste signaling in the gut, mouth, or both on hormonal responses to an oral glucose tolerance test (ogtt) in two groups of subjects with obesity: habitual and non-habitual lcs consumers. validated sensory evaluation techniques will also ascertain subjects' taste perception (aim 3) to test the hypotheses that habitual consumption of lcs blunts perception of sweetness and, in turn, affects postprandial glucose regulation.

Eligibility criteria:
inclusion criteria: * all races/ethnicities * habitual (\> 5 diet sodas per week) and non-habitual (≤1 diet soda or 1 packet of lcs per week) lcs consumers * 30 ≤ bmi \<40 kg/m2 * not severely insulin resistant (homa-ir2 \< 2.6) exclusion criteria: * bmi \< 30 and 40\< bmi kg/m2 * homa-ir2\>2.6 * irregular lcs consumers (\>1 diet sodas or packets of lcs per week but \<5) * current smokers or quit smoking nicotine cigarettes for less than 6 months ago * pregnant, breastfeeding, menopausal * presence of anemia : \<12g/dl for women and \<13g/dl for men * blood donation in the past 8 weeks * presence of malabsorption syndrome * history of bariatric surgery * presence of inflammatory intestinal disease, liver or kidney disease * have diabetes (fasting glucose level \>126mg/dl or plasma glucose level 2h after glucose challenge \>200 mg/dl) * taking any medication that might affect glucose metabolism or the results of our study

Keywords: sweeteners glucose metabolism taste receptors sucralose
evolution of body connection after surgery

Conditions: Pancreas Cancer

Summary: evaluation of psychological impact of patients after pancreatectomy because of cancer diagnosis. patients will be evaluated with questionnaires after and before intervention. 3 control groups will be used to compare de psychological impact.


Eligibility criteria:
inclusion criteria: * patient is older than 18 years old * with a good understanding and practice of the french language * and depending on the group, experimental or control, presenting: * pancreatic cancer expected to be treated with pancreatectomy or planned to be treated with pancreatectomy excluding cancer or breast cancer scheduled to be treated with mastectomy or acute leukaemia at a recent diagnosis (21 days). * no patient's opposition to the information provided * affiliated to the social security plan or beneficiary exclusion criteria: * other medical or psychiatric condition, * level of cognitive efficiency incompatible with response to questions about himself, * a person in an emergency situation, a person under legal protection or unable to express the non opposition to their participation to research.
airways dysfunction following wtc dust exposure

Conditions: Pulmonary Diseases

Summary: in the weeks following the terrorist attacks of september 11, 2001, many patients presented to their physicians with complaints related to exposure to the debris. these included nose and throat complaints (drip, congestion, sore throat), increased ge reflux (heartburn, regurgitation, retrosternal chest burning) and respiratory symptoms (worsening cough, wheezing, shortness of breath, chest tightness, sleep disturbance). in addition, there was a disproportionate rate of self-reported worsening asthma symptoms in patients living in lower new york 5-9 weeks after the attack; those with exposure to the dust cloud fared worse. the functional abnormalities of firefighters with exposures to dust at the wtc site has been recently described. however, the effects of wtc dust exposure on pulmonary function in residents and workers near the wtc site remain unclear. this study will retrospectively review the charts of all patients referred to the pulmonary function laboratory for evaluation of symptoms following exposure to wtc dust. the main objectives for this study will be to characterize the functional abnormalities in these subjects.


Eligibility criteria:
inclusion criteria: * age 18-80 * referral for pulmonary function evaluation of respiratory symptoms following exposure to wtc dust exclusion criteria: * inability to perform testing

Keywords: respiratory function tests oscillometry world trade center disaster environmental exposure distal airways
bilateral transcranial direct current stimulation and ocular occlusion for adults with amblyopia

Conditions: Amblyopia

Summary: a prospective interventional study is expected to be conducted, to test a possible new treatment for amblyopia (lazy eye syndrome). bilateral transcranial direct current stimulation (tdcs) is a type of noninvasive brain stimulation, which may help in visual function recovery of adult patients with amblyopia. this pilot study will test the feasibility of said therapy, along with the short term effects of bilateral tdcs in visual function.

theoretical framework: ocular occlusion treatment has been used classically and with excellent results for the treatment of amblyopia in those under 14 years of age, since in this period it has been seen that there is greater neuroplasticity, leaving little to do in the period of lower neuroplasticity, in young and adult patients with later diagnoses. transcranial direct current stimulation therapy is an emergent technique used in neurological diseases to increase neuroplasticity, by changing the resting potential of neurons. our hypothesis is that the combination of tdcs and visual occlusion therapy is capable of increasing visual acuity, contrast sensitivity, and depth perception, in young people over 18 years of age. methodology: the application of a double-blind, randomized clinical trial is proposed to evaluate the application of 2 different therapies: occlusion with bilateral tdcs, and occlusion with tdcs sham (sham). the study subjects will be randomly assigned to a group, and one session of stimulation will be performed. data will be analyzed using student's t test, or mann-whitney test, according to the normal or non-normal distribution of the sample, respectively. also, the change over time of the variables will be measured using the conditional change model. expected results: the investigators expect that visual acuity, contrast vision, and dichoptic vision in the occlusion therapy group with bilateral tdcs will be significantly higher than the occlusion therapy group with tdcs sham (sham).

Eligibility criteria:
inclusion criteria: * prior diagnosis of amblyopia exclusion criteria: * ophthalmologic disease other than amblyopia * chronic pharmacological therapy * implanted medical device * neurologic disease or surgery history * history of an adverse reaction to tdcs * pregnancy * not able to give informed consent

Keywords: lazy eye syndrome transcranial direct current stimulation ocular occlusion amblyopia
a safety evaluation of drotrecogin alfa (activated) in patients with blood cancer, severe infection related to bone marrow transplantation

Conditions: Sepsis; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Infection

Summary: the purpose is to determine how drotrecogin alfa (activated) will affect patients with blood cancers who develop severe sepsis within 60 days of starting chemotherapy in preparation for bone marrow transplant (bmt).

the purpose of this study is to determine how drotrecogin alfa (activated) will affect leukemia, lymphoma and myeloma patients who develop sever sepsis within 60 days of starting chemotherapy in preparation for bone marrow transplant (bmt). the study will evaluate the safety of xigris by assessing the risk of serious bleeding events, including bleeding within the brain and serious bleeding leading to death.

Eligibility criteria:
inclusion criteria: * participants must have leukemia, lymphoma or myeloma. * participants must have had hematopoietic stem cell transplantation(hsct) within the past 60 days. * participants must have infection with either vasopressor dependent septic shock or ventilator-dependent respiratory failure. * participants must be on a breathing machine or require medication to maintain their blood pressure. exclusion criteria: * participants must not have increased bleeding risk due to medical conditions or medications.
effect of shock wave in reducing chemotherapy- induced peripheral neuropathy in adult and pediatric tumors patients

Conditions: Peripheral Neuropathy

Summary: this study aimed to assess the efficacy of shock wave in reducing chemotherapy- induced peripheral neuropathy in adult and pediatric tumors patients.

peripheral neuropathy is a serious condition characterized by symmetrical, distal damage to the peripheral nerves that may be caused by several classes of drugs, including chemotherapeutic agents. chemotherapy-induced peripheral neuropathy (cipn) is an adverse effect estimated to occur in up to 40% of patients undergoing chemotherapy, with its incidence increasing in patients being treated with multiple agents. pharmacists play a pivotal role in the prevention and management of cipn by recommending evidence-based pharmacologic and nonpharmacologic strategies appropriate for the individual patient.peripheral neuropathy (pn) is a systemic disease characterized by symmetrical, distal damage to the peripheral nerves that negatively impacts patient quality of life (qol). prolonged symptoms associated with pn can cause pain, interfere with functional ability (e.g., dressing, driving, house-work), and disrupt emotional health.

Eligibility criteria:
inclusion criteria: * their age will ranging from eight to forty years. * all cases participated in this study will from both sexes. * all cases receiving chemotherapy as primary treatment, postoperative surgical removal of tumors or with conjunction with radiotherapy * all cases have polyneuropathy caused by chemotherapy. exclusion criteria: * patient with osteoporosis. * patient with dvt. * patient have a pacemaker fitted * uncooperative patients

Keywords: peripheral neuropathy chemotherapy shockwave
diagnostic and prognostic value of cardiac biomarkers for early coronary bypass occlusion in patients undergoing coronary revascularization

Conditions: Coronary Bypass Graft Occlusion

Summary: this study is to evaluate the correlation between hs-ctn level as cardiac biomarker for ischemia and early graft occlusion as assessed by cct in patients undergoing coronary bypass surgery.

the early diagnosis of the periprocedural myocardial infarction (mi) due to the bypass graft occlusion is an important element, in order to introduce early therapeutic strategies. invasive coronary angiography (ca) is the gold standard to evaluate the postoperative myocardial ischemia due to the graft occlusion. since this procedure has several important risks, such as thromboembolic events, dissection, bleeding, and contrast dye-induced nephropathy, in daily clinical practice, only patients with strong clinical suspicion of early mi following coronary artery bypass grafting (cabg) undergo this invasive procedure. there is a clinical need for the development of safe and accurate non-invasive diagnostic approaches to assess the early coronary bypass graft occlusion and to predict the consequent mi. a new clinical approach for the identification of the early post-procedural graft occlusion in patients undergoing cabg surgery is the high-sensitivity cardiac troponin (hs-ctn) cut-off level. the peri-operative bypass occlusion will be assessed by a coronary computed tomography (cct) scan which is a widely available non-invasive approach that permits an accurate evaluation of coronary stenosis. this study is to evaluate the correlation between hs-ctn level as cardiac biomarker for ischemia and early graft occlusion as assessed by cct in patients undergoing coronary bypass surgery.

Eligibility criteria:
inclusion criteria: * patients with isolated coronary bypass surgery exclusion criteria: * patients withholding or lacking informed consent * patients requiring a concomitant procedure * exclusion criteria concerning the cct scan * patients with known allergy to iodine-containing contrast agents * renal function impairment (serum creatinine \>140 mmol/l; estimated glomerular filtration rate (gfr) \<30 ml/min/1.73 m2). * pregnancy * unstable clinical state or severe heart failure * patients with registered mi and registered bypass occlusion in coronary angiogram * patients that didn't undergo a cct prior to discharge

Keywords: coronary artery bypass grafting (cabg) cardiac biomarkers coronary revascularization high-sensitivity cardiac troponin (hs-ctn) myocardial infarction (mi) coronary computed tomography (cct) early coronary bypass graft occlusion
supplementation of probiotics and fruit fibre to patients with fatty liver

Conditions: Fatty Liver

Summary: probiotics and fruit fibre are given for 12 weeks to patients with fatty liver disease. the hypothesis is that probiotic bacteria and fruit fibre affect the gut microbial composition in a positive manner. the improved ecological system is believed to contribute to improved liver health and thereby counteract fatty liver disease.


Eligibility criteria:
inclusion criteria: * be able to participate in magnetic resonance imaging exclusion criteria: * unable to understand oral and written information

Keywords: fatty liver probiotics lactobacillus fruit fibre dietary intervention obesity
evaluation of a simplified method for diagnosis of sleep apnea in children and adults with down syndrome

Conditions: Down Syndrome

Summary: people with down syndrome are at increased risk of sleep apnea, not only from obstruction of the upper airway, but also of central origin. according to published data, sleep apnea may occur in at least 40% of children and adults with down syndrome. consequences of these sleep apnea are numerous : failure to thrive, cognitive decline, high blood pressure, heart disease, accident due to day sleepiness, fatigue. this condition is treatable in people with down syndrome, as it is in ordinary people. diagnosis of sleep apnea in people with down syndrome is therefore a major concern. in addition, data regarding age of apparition of this complication are missing, making repeated screening necessary. polysomnography is the method of choice for the diagnosis of sleep apnea. unfortunately, it is time consuming and sleep departments are heavily busy.

the main objective of our study is to evaluate an easier screening strategy combining questionnaire and overnight recording of few data, compared to polysomnography. we hope our strategy will permit regular screening for people with down syndrome, helping us to draw guidelines for the survey of sleep apnea in this population.

Eligibility criteria:
inclusion criteria: * down syndrome * patient (or parents of children) affiliated in a social regimen * written consent signed (by parents for the children) exclusion criteria: * severe heart failure * insufficient autonomy * diagnosis of insanity, or behavioural problems

Keywords: down syndrome adult children sleep apnea sleep hypopnea polysomnography
postoperative analgesic effects of dexmedetomidine for transversus abdominis plane block

Conditions: Pain

Summary: the aim of this study is evaluate postoperative analgesic effects of dexmedetomidine added to bupivacaine on tap block in patients undergoing lower abdominal surgery.

tap block is being used a method of multimodal balanced analgesia reduces postoperative pain, opioid requirement after surgery and adverse effect of opioid such as sedation, nausea vomiting and ileus. dexmedetomidine ,an alfa-2 adrenoreceptor agonist, is being used and adjuvant capable of prolonging duration of sensory and motor block on nerve blocks.

Eligibility criteria:
inclusion criteria: * asa 1-2 * 18-65 aged * patient undergoing lower abdominal surgery exclusion criteria: * chronic opioid consumption * bupivacaine and dexmedetomidine allergies * coagulopathy * infection at the needle insertion side * chronic liver and kidney disease

Keywords: tap block dexmedetomidine bupivacaine postoperative analgesia
effects of manual lymph drainage on breast engorgement in postpartum period.

Conditions: Postpartum

Summary: there have been many studies on the treatment of breast engorgement, there is a lack of research comparing the effectiveness of manual lymph drainage with massage. therefore, this study will be a randomized controlled trial that aims to compare the effects of manual lymph drainage with massage on breast engorgement, pain, and self efficacy in the postpartum period.

the study will be a randomized controlled trial and will be conducted in jinnah hospital, lahore. this study will be completed in time duration of 10 months after the approval of synopsis. non probability convenience sampling technique will be used and 35 participants will be recruited in study after randomization. the subjects will be divided into two groups and the group a will receive manual lymph drainage and group b will receive massage whereas cold pack will be used as a baseline treatment. the tools that will be used for pre and post treatment assessment are nprs, 6 point self rated engorgement scale and breast feeding self efficacy questionnaire. the data will be assessed after 5 days of treatment using 2 tailed t test. after data collection data will be analyzed by using spss version 25.

Eligibility criteria:
inclusion criteria: women aged 25 to 35 years. lactating mothers who presents with breast pain after birth. women with breast heaviness. women who rate themselves 4 on engorgement scale on six-point self-rated engorgement scale. exclusion criteria: patients with gastrointestinal, urogynaecological, autoimmune or any neurological condition. women with breast cancer. women with breast abcess. women taking other medications.

Keywords: engorgement manual lymph drainage postpartum period pain self efficacy