Kornimate/medical-research-clean huggingface dataset:
a multicenter clinical trial on laparoscopic colorectal cancer surgery compared with open surgery

Conditions: Colorectal Cancer

Summary: the purpose of this study is to verify the 5-year disease free survival (dfs) of resectable colorectal cancer after laparoscopic surgery according to a chinese operative standard was not inferior to open surgery.

study type：interventional study phase：phase iii objectives of study：to verify the 5-year dfs of resectable colorectal cancer after laparoscopic surgery according to a chinese operative standard was not inferior to open surgery. study design：randomized parallel control

Eligibility criteria:
inclusion criteria: 1. informed consent 2. single colorectal adenocarcinoma, located at any segment of the colorectum with lower margin 5cm or more to the dental line 3. ctnm：colon cancer t1-4n1-2m0，rectal cancer t1-3n1-2m0，longest diameter no more than 6cm 4. age less than 80 years old 5. normal blood routine test and hepatic or renal function test 6. no gastrointestinal surgery history or chemotherapy, radiation, no complete obstruction. exclusion criteria: 1. severe comorbidity such as heart attack or stroke, malignance in 5 years 2. can not tolerate to general anesthesia, pneumoperitoneum or surgery 3. pregnant or during breast-feeding period 4. attending other clinical trial involving therapy 5. cannot or disagree to attending the clinical trial
erlotinib versus pemetrexed as second-line therapy in treating patients with advanced lung adenocarcinoma

Conditions: Lung Cancer

Summary: both pemetrexed and erlotinib are second-line treatment options for patients with advanced non-small cell lung cancer. it is controversial that whether it is necessary to detect epidermal growth factor receptor (egfr) mutation status for the egfr-targeted therapy after the failure of standard chemotherapy. the role of egfr gene copy number as a predictive marker remains controversial. therefore, we investigate the efficacy of erlotinib and pemetrexed as second-line therapy in treating in patients with egfr wild-type and egfr fish-positive advanced lung adenocarcinoma.

standard first-line treatment for advanced-stage non-small cell lung cancer (nsclc) usually consists of platinum-based doublet chemotherapy, but progression ultimately occurs for most patients. second-line treatment options available to patients who suffer failure of first-line treatment include further chemotherapy (docetaxel and pemetrexed) or targeted therapy. epidermal growth factor receptor tyrosine kinase inhibitors (egfr-tkis) show great efficacy in patients with advanced nsclc with egfr mutation. high egfr gene copy number was associated with great sensitivity and prolonged progression-free survival of nsclc from egfr-tkis. this phase ii study was designed to assess the efficacy and safety of erlotinib compared with pemetrexed as second-line treatment for egfr wild-type and egfr fish-positive lung adenocarcinoma.

Eligibility criteria:
inclusion criteria: * histologically or cytologically confirmed lung adenocarcinoma * wld-type egfr * stage iiib/iv * failure to prior chemotherapy * life expectancy of more than 3 months * tissue sample desired for genomic study * age ≥ 18 years * performance status (who) \< 3 * adequate bone marrow function (absolute neutrophil count \> 1000/mm\^3, platelet count \> 100000/mm\^3, hemoglobin \> 9gr/mm\^3) * adequate liver (bilirubin \< 1.5 times upper limit of normal and sgot/sgpt \< 2 times upper limit of normal) and renal function (creatinine \< 2mg/dl) * presence of two-dimensional measurable disease. the measurable disease should not have been irradiated * informed consent exclusion criteria: * have previously received pemetrexed or tkis * other concurrent uncontrolled illness

Keywords: cancer non-small-cell lung cancer adenocarcinoma egfr gene mutation chemotherapy pemetrexed erlotinib
the effect of lower limb sensory training on functional capacity in hemiparetic individuals

Conditions: Hemiparesis/Hemiplegia (One Sided Weakness/Paralysis)

Summary: the purpose of our study is to assess the effect of lower limb sensory training on proprioception, balance, gait and motor functions in hemiparetic individuals.

after being informed about the study, all patients giving written informed consent will be determined eligibility for study entry. patients who meet the eligibility requirements will be randomized in a single-blind manner (investigor about assessments). a group will have bobath therapy and the other group bobath and sensory training.

Eligibility criteria:
inclusion criteria: for intervention and control group: * between the ages of 20-65 and discharged from the hospital, * having been diagnosed with hemiparesis at least 4 weeks ago, * first time and one-sided hemiparesis, * modified rankin score ≤3, * hodkinson mental test ≥ 6, * individuals who agree to having treatment will be included in the study. exclusion criteria:for intervention and control group: * having vision and hearing problems, * having other neurological, psychiatric and / or orthopedic problems other than hemiparesis, * medically unstable, * have other diagnosed diseases that will affect lower extremity sensation, * individuals with open wounds, circulatory problems, skin lesions in the area to be treated will be excluded from the study.
nutritional assesment in patients with cirrhosis

Conditions: Cirrhosis, Liver

Summary: this study aims to evaluated nutritional status in patiets with cirrhosis


Eligibility criteria:
inclusion criteria: * signed informed consent * age \>18, \<75 years old * hepatic cirrhosis diagnosis exclusion criteria: * refuse to participate/to give consent * presence of musculo-skeletal disease previous diagnosed, neuropathic diseases, malignancy
a cohort study for occupational stress induced early embryonic death

Conditions: Etiology; Cohort Study; Early Embryonic Death; Occupational Stress; Occupational Epidemiology

Summary: occupation stress can be the risk factors of early embryonic death


Eligibility criteria:
inclusion criteria: 1. pregnant women and their spouses in the gynecology clinic patients and wish to create the cards in the hospital; 2. the gestational age is less than 14 weeks; 3. pregnant women and their spouses have jobs before treatment. exclusion criteria: do not sign the informed consent.
prospective evaluation of cast bivalving for pediatric distal radius fractures

Conditions: Distal Radius Fracture; Loss of Anatomical Alignment After Fracture Reduction

Summary: pediatric patients with distal radius fractures are most commonly treated non-operatively with fracture reduction and cast immobilization. in order to prevent complications from increased swelling after the injury (or fracture manipulation) casts may be split along their length to relieve pressure. however, this can compromise the casts' structural integrity, predisposing fractures to loss of reduction. the goal of this study was to investigate if cast bivalving, or splitting the cast longitudinally on both sides, resulted in any immediate change to bony alignment and to assess if bivalving effected cast parameters associated with loss of reduction.

displaced pediatric distal radius fractures are treated with fracture reduction and cast immobilization. currently, at our institution (and many others) radiographic assessment to determine acceptable fracture alignment and cast parameters is done immediately after cast application. however, afterward casts are often split on both sides along their length, in a process known as bivalving, prophylactically treating for post-traumatic soft tissue edema. while bivalving is felt to relieve pressure from the cast, it may also diminish the structural integrity of the cast. although it is well-established that loss of fracture alignment is most common in the first few weeks after fracture reduction there have been no studies to evaluate any immediate changes to fracture reduction or cast parameters that may occur after bivalving. thus, the goal of this study was to assess if pediatric distal radius fracture alignment was affected by cast bivalving by obtaining post-bivalve radiographs in addition to standard post-cast radiographs.

Eligibility criteria:
inclusion criteria: * guardian must be present * able/eligible to complete follow-up * initial injury within 72 hours * distal radius fracture with or without distal ulna fracture * requiring non-operative management with molded cast exclusion criteria: * open fractures * re-fractures * pathologic fractures * fractures associated with neurovascular injury * poly trauma incident * intubated patients or unable to verbalize symptoms of pain * preexisting medical history that effects musculoskeletal health

Keywords: cast pediatric cast index distal radius fracture loss of reduction bivalve
registry for pulmonary hypertension in china

Conditions: Pulmonary Arterial Hypertension; Chronic Thromboembolic Pulmonary Hypertension; Death

Summary: 1. to characterize the demographics and clinical course of the patient population diagnosed as having who group i pulmonary arterial hypertension and who group iv pulmonary hypertension due to chronic thromboembolic pulmonary hypertension 2. to describe real-world outcome of chinese patients with who group i pulmonary arterial hypertension and who group iv pulmonary hypertension due to chronic thromboembolic pulmonary hypertension 3. to evaluate differences in patient outcomes according to classification subgroup 4. to identify clinical predictors of long-term survival 5. to assess the relationship between targeted therapies for pulmonary arterial hypertension and patient outcomes

data describing the natural history of idiopathic and familial pulmonary arterial hypertension were derived from a registry conducted at our institution prior to 2006. since then, targeted therapies for pulmonary arterial hypertension have been introduced in china. it is probably that the prognosis of chinese patients with who group i pulmonary arterial hypertension and who group iv pulmonary hypertension due to chronic thromboembolic pulmonary hypertension has also been improved as western countries. therefore, the aim of the present study was to describe real-world outcome of chinese patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension and identify factors that may predict outcome. our study will provide an updated picture of the clinical course of a more broadly defined scope of pulmonary hypertension and the effects of current therapy on survival, enabling the collection of data on demographics, clinical course, treatments, and outcomes.

Eligibility criteria:
inclusion criteria: * signed patients'consent * diagnosed by right heart catheterization one month within study enrollment * patients who were firstly diagnosed as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension exclusion criteria: * not meeting inclusion criteria

Keywords: hypertension,pulmonary mortality risk factors
anatomical scale for the prognosis of fournier syndrome.

Conditions: Fournier&#39;s Gangrene

Summary: type of study: case series. universe of study: records of patients with fournier syndrome treated using the 3-stage reconstructive technique assigned and treated at the mexican social security institute: regional general hospital no. 1 of mérida, yucatán, during the years 2021-2024. population under study: patients diagnosed with fournier syndrome.

the first surgical stage consists of damage limitation and extension analysis. in the second surgical stage, it was necessary to wash and prepare the area to be remodeled with the joint creation of the testicular resting space delimited by the fascia of the adductor muscles of the proximal lower limb. finally, in the third surgical stage, the wound is remodeled and addressed. the surgery was performed in patients with extensive involvement that could not be resolved with minor surgery. the 3-stage reconstructive technique can be summarized as follows: 1. analysis and limitation of the tissue injury. bilateral testicular and spermatic cord dissection. 2. formation of cutaneous flaps and bilateral inguinal neocavity. 3. perineal-scrotal reconstruction with fascial facing and cutaneous flaps

Eligibility criteria:
inclusion criteria: - patients diagnosed with perineal necrotizing fasciitis (fournier syndrome), at the general hospital zone no. 1, aged between 40-85 years, who have undergone surgery exclusion criteria: * those who could not be followed up due to incomplete records. those who did not complete the three procedures due to mortality associated with primary pathologies independent of necrotizing fasciitis.

Keywords: surgery infection tissue scrotal
the metabolic effects of antidepressants in patients diagnosed with major depressive disorder

Conditions: Major Depressive Disorder

Summary: objective there is growing evidence showing a relation between depression, metabolic syndrome, diabetes, cardiovascular disease (1), serum lipid profile (2,3) and body weight (4), as well as the effects of some of the antidepressant medications on these various conditions and profiles. the aim of the study is to examine the influence of antidepressant medications on the metabolic profiles (5) of patients suffering from major depressive disorder (mdd). group of patients: 30 patients aged 18-65, who were diagnosed with mdd according to the dsm-iv criteria. research design and methods: research duration will be 8 weeks. patients meeting the inclusion criteria will be recruited after being diagnosed with mdd and having undertaken the hdrs. a follow-up hdrs will be taken at weeks 4 and 8. the psychiatric evaluation will be held by a resident in psychiatry. the following metabolic parameters will be examined at base-line and at the end of the 8 weeks: weight, height, waist circumference, body mass index (bmi: (weight in kg/(height in meters)2), sitting blood pressure (after 3 minutes of sitting). serum lipid profile (performed in ziv hospital's chemistry lab): low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, total cholesterol, apolipoprotein level (apo ai, apo b, apo e, apo aii). fasting glucose and insulin blood levels, in order to evaluate insulin-release and resistance, according to the following formulas: insulin resistance: homa ir=fasting glucose (mg/dl)x fasting insulin (mmol/l)/405 insulin release: homa-β={360xfasting insulin (mmol/l)}/{glucose(mg/dl)-63} serum oxidative stress parameters according to the f2-isoprostane kit will be measured. malonylaialdehyde (mda) content in serum will be analyzed by the thiobarbituric acid reactive substances assay, which measures malondialdehyde equivalent (13). conjugated dienes will be measured at 234nm (14, 15).


Eligibility criteria:
inclusion criteria: * mdd diagnosed patients with a hamilton depression rating scale (hdrs) score of at least 18 points. patients not treated with medications or such that had shown resistance to treatment, and were therefore assigned for drug replacement. * patients on stable therapy for hypertension, diabetes mellitus, hypothyroidism, dyslipidemia and / or weight lowering medications exclusion criteria: * patients receiving antipsychotic treatment as well as patients on mood stabilizers will be excluded. * patients with uncontrolled diabetes mellitus, uncontrolled thyroid functioning, or uncontrolled hypertension, as well as patients who regularly consume alcohol will be excluded. * patients with uncontrolled malignancy are excluded as well.

Keywords: major depressive disorder antidepressants
us guided sacroiliac joint injection

Conditions: Pain

Summary: sacroiliac joint (sij) pain is one of the underappreciated causes of low back pain. recent studies have reported excellent outcomes after ultrasound (us) guided sij injection with local anesthetics and corticosteroids, but these studies are characterized by wide variability in selection criteria and patient characteristics; therefore, there is a need to determine whether any demographic or clinical variables can be used to predict us-guided sij injection outcomes.

this study is testing the different predictors related to the patient that could affect his improvement by \>50% after us guided sij injection with anaesthetic and steroids

Eligibility criteria:
inclusion criteria: * sacroiliac pain exclusion criteria: -
molecular markers of acute kidney injury in elderly deceased donors

Conditions: Kidney Transplantation; Acute Kidney Injury

Summary: scoring systems that combine donor clinical and morphological parameters to predict outcome of kidney transplantation lack enough specificity to be generally accepted. compare to classical histology, molecular assessment of renal tissue offers unbiased and technically robust approach. in this prospective 3-months' observational study procurement biopsies in 180 brain death donors will be performed. using microarray which detect top differently regulated genes, conventional histology, urinary aki biomarkers, renal function and clinical variables models predicting dgf and early graft scarring (ifta, poor graft function) in recipients will be constructed. the associations of aki in donors with distinct fibrosis atrophy and aki molecular signals will be found. molecular techniques and final models may help to improve the decision-making process for the acceptance of kidneys from marginal donors but more importantly, it may help clinicians to guide less toxic immunosuppression in identified problematic grafts.

the aim is to create a prediction model of early clinical outcome (delayed graft function) based on donor and recipient clinical variables, donor egfr, urinary aki biomarkers, histology (glomerulosclerosis, interstitial fibrosis, vascular changes) and top differently regulated genes found in microarray of wedge procurement donor biopsy. construct a model capable to predict early renal allograft scarring (ifta\>2), and impaired graft function (egfr\<45 ml/min), as early as at 3 months. describe renal molecular changes associated with established aki in brain-death deceased donor and with aging.

Eligibility criteria:
inclusion criteria: * all dbd (donation after brain death) donors whose kidneys will be procured by transplant team of institute for clinical and experimental medicine (ikem) in donor hospital. * all dbd (donation after brain death) donors whose kidneys will be procured by transplant team of institute for clinical and experimental medicine (ikem) at ikem. exclusion criteria: * donors with circulatory death * donors with machine perfusion * donors with multiorgan transplantation.

Keywords: kidney transplantation donor kidney microarray
comparison between effect of vitamin d versus dexmedetomidine in patients with head trauma using interleukin 6

Conditions: Traumatic Brain Injury

Summary: in this study the investigators compare between the neuroprotective effect of vitamin d versus dexmedetomidine in patients with traumatic brain injury using interleukin 6 as inflammatory biomarker

patients with moderate head trauma (gcs 8-12) within first 24 hours were randomly divided into 2 groups, first group received 100,000 iu of vitamin d was given im \& the other group received dexmedetomidine 0.4 mic/kg as loading dose then 0.25 mic/kg/hr as maintainence dose for 5 days detecting apatche at admission and following up of vital signs (hr \& nibp) \& investigations (cbc \& rft\& abg \& esr\& crp \& il-6) \& gcs and gos for 5 days.

Eligibility criteria:
inclusion criteria: * both gender. * age (18-50) * gcs (8-12) * pt with traumatic brain insult who not indicated surgical intervention exclusion criteria: * prior severe disability. * isolated brain system lesions. * history of underlying neurologic, metabolic or psychiatric disorders. * alcohol or drug abuse. * pregnancy. * patients with intracranial hemorrhage who indicated surgical evacuation. * multisystem life-threatening trauma. * gcs \> 12 \& \<8. * vitamin d deficiency.
rhinaer procedure for treatment of chronic rhinitis study

Conditions: Chronic Rhinitis

Summary: the purpose of this study is to compare the rhinaer procedure with radiofrequency (rf) energy to sham procedure for treatment of chronic rhinitis.

the purpose of this study is to compare the rhinaer procedure to treat tissue in the posterior nasal nerve area to improve symptoms in adults diagnosed with chronic rhinitis with a sham procedure that duplicates the actual procedure as closely as possible absent the delivery of radiofrequency (rf) energy to the nasal tissue.

Eligibility criteria:
inclusion criteria: 1. age 18 to 85 years (inclusively). 2. willing and able to provide informed consent. 3. willing and able to comply with the subject-specific requirements outlined in the study protocol. 4. seeking treatment for chronic rhinitis symptoms of at least 6 months duration and willing to undergo an office-based procedure. 5. moderate to severe symptoms of rhinorrhea (rtnss rating of 2 or 3 for rhinorrhea). 6. mild to severe symptoms of nasal congestion (rtnss rating of 1, 2 or 3 for congestion). 7. rtnss ≥ 6. exclusion criteria: 1. anatomic obstructions that in the investigator's opinion limit access to the posterior nasal passage. 2. altered anatomy of the posterior nose as a result of prior sinus or nasal surgery or injury. 3. active nasal or sinus infection. 4. history of significant dry eye. 5. history of any of the following: chronic epistaxis, documented episodes of significant nose bleeds in the past 3 months, rhinitis medicamentosa, head or neck irradiation. 6. have rhinitis symptoms only on a seasonal basis due to allergies. 7. known or suspected allergies or contraindications to the anesthetic agents and/or antibiotic medications to be used during the study procedure session. 8. known or suspected to be pregnant or is lactating. 9. participating in another clinical research study. 10. has any condition that predisposes to excessive bleeding. 11. is taking anticoagulants (eg, warfarin, plavix) or 325 mg aspirin that cannot be discontinued before the procedure. 12. has previous procedure or surgery for chronic rhinitis. 13. other medical conditions which in the opinion of the investigator would predispose the subject to poor wound healing, increased surgical risk, or poor compliance with the requirements of the study.
serious gaming for chemotherapy-induced nausea and vomiting

Conditions: Neoplasms; Chemotherapy-induced Nausea and Vomiting

Summary: the purpose of this study is to examine the effectiveness of a technology-based intervention for managing nausea and vomiting in older adults with cancer. participants will be randomized to either an intervention or control group. outcomes such as symptom severity, quality of life, and resource use will be examined.

the goal of this study is to increase the use of preventative self-management behaviors for nausea and vomiting in older adults receiving chemotherapy to reduce negative outcomes and emergency or hospital admissions. early reinforcement of standard education and re-framing any preconceived beliefs about the ability of nausea and vomiting to be managed will increase preventative self-management behaviors and improve patient outcomes. participants will be in the study for 6 chemotherapy treatment cycles. this could be 12 to 24 weeks depending on if they receive treatment every 2, 3 or 4 weeks.

Eligibility criteria:
inclusion criteria: * age 60 or older * newly diagnosed with cancer * treatment with any chemotherapeutic agent of moderate or high emetic potential * on a 2, 3 or 4 week treatment cycle * proficient in english * has a telephone exclusion criteria: * previous diagnosis and/or treatment for cancer * end stage disease with less than 6 months to live * visually or hearing impaired without corrective device

Keywords: aged digital technology nausea neoplasm drug related side effects and adverse reactions self-management