Kornimate/medical-research-clean huggingface dataset:
books, videos and mobile games i̇n pediatric dentistry

Conditions: Dental Anxiety; Child, Only

Summary: the objective of this study was to examine the impact of educational video viewing, reading educational books, and playing educational mobile games on children's dental anxiety prior to dental examinations. the main questions it aims to answer are: 1. does reading educational books before dental examinations reduce dental anxiety in children? 2. does watching educational videos before dental examinations reduce children's dental anxiety? 3. does playing educational mobile games before dental check-ups reduce dental anxiety in children?

ackground: behaviour management techniques have an important place in paediatric dentistry. however, alternative methods may be needed if they are found to be ineffective in reducing children's dental anxiety.aim: this study aimed to evaluate the impact of reading educational books, watching videos and playing mobile games from the child's, dentist's and parent's perspective on children's dental anxiety before treatment. methods: a total of 160 patients were randomly assigned to four groups. anxiety levels of patients in each group were assessed using the facial image scale, the frankl behaviour scale and pulse oximetry. the corah dental anxiety scale was administered to parents to assess their child's anxiety level. the first group was exposed to the tell-show-do technique, the second group read a book, the third group watched a video and the fourth group played a mobile phone game. the children in each group were then assessed. anxiety levels were then reassessed using the same scales.

Eligibility criteria:
inclusion criteria: 1. the child must be between 3-6 years old 2. no previous dentist experience 3. no systemic disease or syndrome exclusion criteria: 1. the child is under 3 years old and over 6 years old 2. having been to the dentist before for an examination or dental treatment. 3. having any systemic disease or syndrome

Keywords: book dental anxiety behavior management video mobil game
genetic and inflammatory markers in cardiovascular disease (gem) registry

Conditions: Atherosclerosis

Summary: this is an investigator initiated registry aimed at assembling a blood/serum and genomic resource (bank) of human blood samples with accompanying clinical data mainly from patients who are scheduled to undergo cardiac catheterization at uc davis medical center, but may also include other eligible individuals. funding is from institutional/divisional research funds.

this study is aimed at assembling a blood/serum and genomic resource (bank) of human samples with accompanying clinical data mainly from patients who are scheduled to undergo cardiac catheterization at uc davis medical center, but may also include other eligible individuals. these samples will be analyzed at uc davis medical center for determination of biomarker levels, and concomitantly analyzed at uc san francisco in an irb-approved protocol at that institution for genetic analysis (ucsf irb approval # for this study is h711-15138-03; protocol name is "discovery of gene mutations and polymorphisms that contribute to the risk of atherosclerosis"; principal investigator is john p. kane, md). all samples sent to ucsf will be de-identified and catalogued using an alphanumeric code. a number of candidate genes will be studied to detect mutations and polymorphisms that could contribute to the risk of atherosclerosis. the technique of hybridization sequencing will be employed for this. the techniques of classical statistical genetics will be employed for both cosegregation analysis and for the genome search approach. clinical follow-up may be obtained at 6 and 12 months.

Eligibility criteria:
inclusion criteria: * any individual cared for in the uc davis health system * disorders of lipoproteins or arteriosclerosis exclusion criteria: * subjects will be excluded only if they refuse to be in the study

Keywords: gem arteriosclerosis biomarkers atherosclerosis
far infrared therapy on peritoneal function of capd patients

Conditions: End-stage Renal Disease

Summary: for patients with end-stage renal disease, peritoneal dialysis (pd) has been proven to be an alternative choice compared to hemodialysis as a type of maintenance renal replacement therapy. despite this, long-term pd is associated with structural membrane changes that are believed to contribute to alterations in solute transport and loss of ultrafiltration. previous studies have proven that far-infrared (fir) therapy may improve not only the arteriovenous fistula patency in hemodialysis patients but also abdominal discomfort due to encapsulating peritoneal sclerosis in pd patients. since there is little information concerning this issue, this study was conducted in order to evaluate the possible effects of fir therapy on the peritoneal function of patients receiving continuous ambulatory peritoneal dialysis (capd). the objective of this study is to evaluate the effect of fir therapy on the peritoneal function, protein loss, and ultrafiltration capacity of capd patients.

a total of 100 capd patients will be enrolled in this study, including 50 in treatment group who will receive fir therapy for 6 months and 50 in control group. many parameters of blood and urine samples as well as ultrafiltration amount, dialysate urea nitrogen, creatinine, na+, k+, total protein, ca-125, and glucose degradation product (gdp) for the dialysate effluent of not only the first and last exchanges but also the total exchanges of daily pd regimen will be measured for both groups at day 1 and 6th month. however, only the fir group will receive tests of blood, urine and dialysate on day 2. the significance of the study is that patients might benefit from the prophylactic therapeutic effects of fir therapy, leading to the reduction of the hospitalization costs and the need for interventional procedures in capd patient care in taiwan.

Eligibility criteria:
inclusion criteria: * chronic peritoneal dialysis patients who have not received any fir therapy within the previous 12 months * patients on a standard continuous ambulatory peritoneal dialysis (capd) (1.5-2 l; 4-5 exchanges/day) or ambulatory peritoneal dialysis (apd) program exclusion criteria: * history of capd-related peritonitis within 3 months prior to the study period; * history of cerebrovascular accident or myocardial infarction or interventional procedure (percutaneous transluminal coronary angioplasty or stent) for coronary artery disease within the 3 months prior to the study

Keywords: peritoneal dialysis far infrared therapy
study to evaluate the safety and effectiveness of mrgfus compared with myomectomy for the treatment of uterine fibroids

Conditions: Uterine Fibroids; Bleeding; Pelvic Pain

Summary: the objective of this trial is to evaluate the safety and efficacy of exablate for the treatment of uterine fibroids. women, seeking treatment for symptomatic uterine leiomyomata will be eligible for the study.women who agree to participate will sign an informed consent and will be randomized to exablate treatment or myomectomy. all patients will be followed through the 36 month visit. follow-up visits/telephone calls will be completed at 1 week, 2 weeks, 6 weeks, 3 months, 6, 12, 18, 24 and 36 months post treatment. patients will be evaluated by assessing their overall physical and mental health as well as for device/procedure related adverse events.


Eligibility criteria:
inclusion criteria: 1. women age 18 or older 2. symptomatic uterine fibroids, defined as those resulting in scores of 21 or higher, based on patient responses to questions 1-8 (raw score) of the uterine fibroid symptom and health-related quality of life questionnaire (ufs-qol). 3. women who have given written informed consent 4. women who are able and willing to attend all study visits 5. patient is pre or peri-menopausal (within 12 months of last menstrual period) 6. able to communicate sensations during the exablate procedure 7. uterine fibroids, which are device accessible 8. fibroid(s) clearly visible on non-contrast mri. 9. fibroid(s) enhances on mr contrast imaging exclusion criteria: 1. women currently pregnant 2. uterine size \> 24 cm w/o the cervix 3. more than 4 clinically significant fibroids (per mri) 4. prior myomectomy, uae 5. allergy to either gadolinium or iodinated contrast 6. implanted metallic device prohibiting mri 7. severe claustrophobia 8. active pelvic infection 9. current use of intrauterine contraceptive device 10. unstable medical conditions requiring additional monitoring during the procedure 11. bleeding diathesis requiring medical treatment 12. imaging suggestive of malignant disease of uterus, ovary, or cervix 13. imaging and suggestive of adenomyosis. 14. pedunculated submucosal or pedunculated subserosal myoma 15. size and weight which prohibits subject from fitting in mri device 16. unavoidable, scarring, skin folds or irregularity, bowel, pubic bone, iud, surgical clips or hard implants in the beam path. 17. hyper intense fibroid relatively to the uterus muscle 18. women with ovarian dermoid cyst anywhere in the treatment path

Keywords: mrgfus uterine fibroids pelvic pain quality of life symptomatic uterine fibroids
exercise training on a mirror for intermittent exotropia control post strabismus surgery

Conditions: Exercise Training; Intermittent Exotropia; Strabismus

Summary: the study aims to explore the impact of mirror therapy on exodeviation control, near and far strabismus angles, and quality of life in intermittent exotropia control post strabismus surgery, as well as its effects on near and far strabismus angles.

strabismus is a common childhood disorder causing eye deviation, affecting life quality and cosmetic appearance. early detection and management improve binocular function and psychosocial problems. intermittent exotropia is a common type. surgery is the most common method for correcting strabismus, but complications can be difficult to treat. physical therapy programs are limited in treating strabismus after surgery, and adding mirror therapy to traditional treatments may help maintain surgery results. this thesis aims to decrease this knowledge gap and improve the treatment of strabismus.

Eligibility criteria:
inclusion criteria: 1. 40 boys and girls with ages from 5 to 15 years 2. history of strabismus surgery from 6 months presence of intermittent exotropia. 3. normal sensory and motor fusion, equal visual acuity. good general health condition. 4. ability to understand and do the exercises at home exclusion criteria: 1. systemic diseases as myasthenia gravis, multiple sclerosis and diabetes 2. optic nerve injury, organic ocular disease, attention disorder and mental disorders 3. attention disorder and learning disability
first research study to compare a possible new medicine nnc9204-1513 to the medicine glucagon, in healthy people.

Conditions: Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2

Summary: the study is comparing the new medicine nnc9204-1513 with a standard therapy of glucagon (glucagen®). this is the first time nnc9204-1513 is given to humans. participants will either receive nnc9204-1513 or glucagen® - which treatment you get is decided by chance (like flipping a coin). neither the participant nor the study doctor will know which study medicine (nnc9204-1513 or glucagen®) the participant is receiving (double -blinding). in case of emergency, this information will be readily available. nnc9204-1513 is a new medicine for rescue treatment of severe low blood sugar and currently not available on the market (doctors cannot prescribe this medicine). the participant will receive two or three single injections below the skin. one injection will contain nnc9204-1513 or glucagen®. the other injection will include placebo - this is a product that looks like the actual study drug but without any active ingredients. if a third injection is given, this will contain nnc9204-1513 or placebo. nnc9204-1513 and glucagen® will be given using different devices and volumes. in order to mask these external differences, a "double dummy" approach will be used, that means when you get either of the study medicine (nnc9204-1513 or glucagen®) you will get another injection which contains no medicine called 'placebo' (it will not have any effect on the body). dependent on the injection volume to be administered, injections are given by either syringe with needle or an injection pen (novopen echo®). the study will last for up to 39 days.


Eligibility criteria:
inclusion criteria: * male, aged 18 -55 years (both inclusive), at the time of signing informed consent * body mass index (bmi) between 18.5 and 28.0 kg/sqm (both inclusive) * considered to be generally healthy based on the medical history, physical examination, and the results of vital signs, ecg and clinical laboratory tests performed during the screening visit, as judged by the investigator exclusion criteria: * any disorder which in the investigator's opinion might jeopardise subject's safety, evaluation of results, or compliance with the protocol * smoker (defined as a subject who is smoking at least one cigarette or equivalent daily) who is not able or willing to refrain from smoking and use of nicotine substitute products during the inpatient period * any blood draw in excess of 25 ml in the past month, or donation of blood or plasma in excess of 400 ml within the 3 months preceding screening
spaulding-harvard model system: effects of transcranial direct current stimulation (tdcs) on chronic pain in spinal cord injury

Conditions: Spinal Cord Injury; Chronic Pain; Neuropathic Pain

Summary: the purpose of this study is to see the effects of transcranial direct current stimulation (tdcs) on the pain associated with spinal cord injury. this study is part of the spaulding-harvard model system. the investigators hypothesize that there will be a decrease in pain levels with active stimulation, when compared to sham stimulation, using a 3 week stimulation schedule- 1 week of stimulation (5 consecutive days) followed by 2 weeks of stimulation (10 consecutive days) after a 3-month follow up visit. the subject will also have follow ups at 2, 4 and 8 weeks after the second course of stimulation. if a subject receives sham during the experiment, he/she may enroll in an open-label portion of the study and receive 10 days of active stimulation.


Eligibility criteria:
inclusion criteria: * over 18 years of age * history of moderate to severe sublesional pain exclusion criteria: * active alcohol or drug dependence, as self-reported * a history of bipolar disorder or psychosis, as self-reported * inability to travel to the study site, * current use of any of the following anti-epileptic medications or dopaminergic medications known to reduce or inhibit the benefits of tdcs treatment \[53\]: carbamazepine, oxcarbazepine, phenytoin, ropinirole (requip), pramipexole (mirapex), and cabergoline (dostinex), * the following contradictions to tdcs: implanted metal plates in the head, or deep brain stimulator (spinal cord implants, including baclofen pumps, are not a contraindication as cranial currents do not reach the spinal cord \[24\]). * pregnancy at time of enrollment * current use of ventilator.

Keywords: transcranial stimulation direct current
a retrospective study on the effect of hba or hbb genetic defects on early embryonic development

Conditions: Thalassemia,Embryonic Development,Reproductive Sterility and Infertility

Summary: thalassemia is an anemia or pathological state caused by compounding absently or inadequately of one or more globin chains of hemoglobin due to the defects of the globin gene,and the carrying rate is high in southern china. although there are many studies of thalassemia, the relationship between the globin gene defects and the early embryo development has not been reported. this study intends to carry out a retrospective analysis on the embryonic development of the patients with thalassemia assisted by pgd from january 1, 2011 to now in our hospital, to explore whether the hba or hbb gene defects have a certain influence on the early embryo development, so as to accumulate certain data for reproductive health research.


Eligibility criteria:
inclusion criteria: * infertility couples with thalassemia(one or both ) * infertility couples treat by pgd exclusion criteria: * abortion of amplification for blastula biopsy * pgd without diagnostic results or with unclear diagnostic results * embryos with both hba and hbb genetic defect
a study of cs1003 in subjects with advanced solid tumors or lymphomas

Conditions: Solid Tumor; Lymphoma

Summary: this is a phase ia/ib, open-label, multiple-dose, dose-escalation and expansion study to evaluate the safety, tolerability, pharmacokinetics and anti-tumor activity of cs1003 in subjects with advanced solid tumors or lymphoma.


Eligibility criteria:
inclusion criteria: 1. willing to sign the informed consent. 2. subjects must have histologically or cytologically confirmed advanced or metastatic solid tumor or unresectable lymphoma and have progressed, are intolerant to, refuse to accept or do not have access to standard therapy. 3. ecog performance status of 0 or 1. 4. subjects with evaluable but non-measurable lesion are eligible for phase ia. subjects must have at least one measurable lesion per recist version 1.1 to be eligible for phase ib. 5. archived tumor tissue samples need to be collected, or subjects consent to undergo pre-treatment biopsy if archived sample is not available. 6. life expectancy ≥ 3 months. 7. subject must have adequate organ function. 8. use of effective contraception (males and females). exclusion criteria: 1. subjects with known symptomatic or untreated brain metastasis or other cns metastasis. 2. subjects with active autoimmune diseases or history of autoimmune diseases. 3. subjects who have to receive glucocorticoids (prednisone at \> 10 mg/day or equivalent) or other immunosuppression within 14 days prior to the first dose of cs1003. 4. subjects with other malignant tumor(s) in the past 2 years are not eligible for phase ib 5. subjects who have received any immune checkpoint treatment, including pd-1, pd-l1, etc. 6. history of hiv infection. 7. subjects with active hepatitis b and c infection requiring therapy. 8. subjects with active infection of tuberculosis. 9. history of organ transplantation. 10. unresolved toxicities from prior anti-cancer therapy. 11. history of uncontrolled allergic asthma and serious hypersensitive reaction to monoclonal antibodies. 12. subjects with major cardiovascular diseases. 13. history of alcoholism or drugs abuse. 14. any condition that, in the opinion of the investigator or sponsor, would jeopardize compliance.
shockwave lithotripsy (swl) under selective, general anesthesia.

Conditions: Renal Calculi; Ureteral Calculi

Summary: swl is widely used in the treatment of patients with renal and ureteral calculi. several factors determine the success of extracorporeal shockwave lithotripsy (swl) for kidney stones: stone size, stone location within the collecting system, stone type, and the swl machine used. moreover, in some cases it is very difficult to focus on the stone because of its movement as a results of breathing. in order to prevent stone movement we want to use a bronchial blocker, processing a selective ventilation of the opposite side of stone location.


Eligibility criteria:
inclusion criteria: * older than 18 years old * not pregnant * all patients who failed in swl process, taken under sedation (standard protocol) exclusion criteria: * age \< 18 * pregnancy
the influence of exercise on mental health after discharge from hospital

Conditions: Quality of Life

Summary: the aim of this study is to evaluate the effect of aerobic fitness training on mental health (health-related quality of life),cognitive and physical capacity in older people discharge from hospital and to assess if further aerobic training at home enhances the effect. design: randomized controlled trial conducted at oslo university hospital, department of medicine in conjunction with oslo university college. the subjects will be randomized into one intervention group (training group) or one control group. outcome measure: health-related quality of life physical function cognitive capacity physical activity body composition physical activity level

research has indicated that participation in a regular exercise program is an effective intervention to maintain and enhance cognitive and physical function in older individuals.despite good evidence regarding the positive effects of exercise, a sedentary or inactive lifestyle is common among people over 65 years of old, especially among persons with chronic diseases. research shows that good mental health and physical capacity is of vital importance for living independently in the community and we know that participation in physical activity offers good opportunities to extend years of active independent life. nevertheless our knowledge is sparse regarding the evidence of effective programs for health promotion in groups of elderly, especially after discharge from hospital. our knowledge is also sparse as to which intervention program is the most effective, group-based training or home- based training.

Eligibility criteria:
inclusion criteria: * 70 years or older * be able to perform the timed up and go test without use of assistive device exclusion criteria: * chronic disease with expected lifespan \< 1 year * exercise regularly more than twice a week * cognitive impairment mms \< 24 * assessed by a doctor not to tolerate aerobic exercises * exercise limiting cardiovascular or musculoskeletal disease

Keywords: hlrq elderly aerobic fitness cognitive capacity
food environment, food insecurity, and health behaviors in nh hispanics

Conditions: Obesity; Food Insecurity

Summary: this telephone-based survey included adults of hispanic/latino background residing in new hampshire (nh). information on food security and access, food environment, and health status and behaviors was collected through validated questionnaires. this project addresses the need for assessment of barriers to nutrition and health during covid-19 in this population.

this telephone-based survey included a convenience sample of hispanic/latino adults (\>18 years) with cultural origin in a spanish-speaking country and residing in nh. a subgroup of the study population was assessed at baseline and 6-months following baseline. validated questionnaires assessing the following outcomes were included: * demographics * food access * food security * physical activity * dietary intake * eating behaviors * weighing behaviors * psychology * sleep behaviors * acculturation * gastrointestinal symptoms * covid-19 vaccine behaviors objective food access will be assessed through mapping and calculation of proximity of subjects' residential addresses to various food sources.

Eligibility criteria:
inclusion criteria: * hispanic or latino cultural background * current new hampshire resident exclusion criteria: * previous participation (cannot complete the survey more than once unless re-contacted for follow-up)

Keywords: hispanic/latino psychosocial wellbeing overweight and obesity food insecurity covid-19 pandemic
zenith® lp abdominal aortic aneurysm (aaa) post-market registry

Conditions: Abdominal Aortic Aneurysm; Aorto-iliac Aneurysm

Summary: a registry to collect additional prospective intra-operative and follow-up information on physician use of the ce-marked zenith® low profile abdominal aortic aneurysm (aaa) endovascular graft under routine clinical care.


Eligibility criteria:
inclusion criteria: * patient is implanted with zenith® low profile aaa endovascular graft exclusion criteria: * patients for whom this device would not normally be considered standard of care.

Keywords: low profile endovascular graft endovascular procedure aortic aneurysm, abdominal aortic aneurysm