Kornimate/medical-research-clean huggingface dataset:
us time-harmonic elastography for the early detection of childhood glomerulonephritis

Conditions: Glomerulonephritis

Summary: us time-harmonic elastography for the early detection of childhood glomerulonephritis

glomerulonephritis (gn) comprises a group of renal diseases characterized by glomerular and tubulointerstitial fibrosis secondary to glomerular inflammation and proliferation of the basement membrane, mesangial cells, or capillary endothelium triggered by immunologic mechanisms.(1) the glomerular filtration rate decreases with progression of chronic kidney disease (ckd), ultimately resulting in end-stage renal failure. glomerulonephritis is the third most common cause of end-stage renal failure. initial clinical signs of glomerulonephritis are nonspecific and subtle. occasionally, affected patients present with hypertension, proteinuria, hematuria, raised serum creatinine level, weight gain, edema, or nephrotic syndrome.(2) the underlying pathologic changes are partly irreversible, and a prompt diagnosis with early initiation of treatment is of vital importance. the diagnosis is based on clinical, laboratory, and conventional us findings, whereas renal biopsy is considered the reference standard for a definitive diagnosis and fibrosis grading.(3,4) unfortunately, this invasive procedure is associated with the risk of serious bleeding complications and therefore is not the method of choice for longitudinal monitoring. elastography, a novel imaging modality that estimates tissue stiffness, especially for superficial organs such as the breast and thyroid. in recent years, ultrasound elastography (ue) has been demonstrated in the liver and has been applied widely in the diagnosis and evaluation of liver diseases, such as chronic hepatitis, alcoholic liver diseases, and non alcoholic fatty liver diseases.(5,6) to date, renal allograft stiffness (elasticity) has been evaluated by magnetic resonance elastography (mre) and ultrasound elastography (ue). however, ue application for native renal diseases has not been well up till now.(7) conventional renal ultrasonography may be appropriate to evaluate kidney size, as well as to assess the echogenicity of the renal cortex, exclude obstruction, and determine the extent of fibrosis. however, it has no significant role in diagnosis of gn. us time-harmonic elastography depicts abnormal renal stiffness in glomerulonephritis, particularly among patients with early disease and preserved renal function.(8,9,10)

Eligibility criteria:
inclusion criteria: 1. age 1 month up to 18 years 2. patientswith acute glomerulonephritis either poststreptococcal , lupus, anca related, or ig a nephritis . diagnosis of such diseases will be done through usual clinical, laboratory , radiological and histopathological data exclusion criteria: patients with clinical, laboratory , or radiological evidence of chronic kidney disease
trial of ropinirole in motor recovery after stroke

Conditions: Cerebrovascular Accident; Hemiparesis

Summary: the purpose of this study is to assess efficacy, as well as safety, of ropinirole in improving movement among patients with chronic stroke.

stroke is a leading cause of disability. current treatments target injury and must be delivered within hours. a body of literature suggests that there are processes ongoing days-months after stroke that can be targeted therapeutically, and improve function. the current study evaluates one such potential therapy, the dopamine agonist ropinirole. the current study tests the hypothesis that patients with chronic stroke randomized to ropinirole+physiotherapy will show improved gait velocity over the 12 weeks of study participation as compared to patients randomized to placebo+physiotherapy. a secondary aim is to test the hypothesis that ropinirole will improve three secondary endpoints at 12 weeks after study entry: the proportion of patients with no significant disability (barthel index ≥ 95); overall motor status, measured with the arm/leg fm score; and overall physical function, defined as the score on the stroke impact scale-16 (sis-16). this study will also evaluate the safety of ropinirole in patients recovering from stroke.

Eligibility criteria:
inclusion criteria: 1. stroke onset 4 weeks-12 months prior 2. stroke is radiologically confirmed as either (a) ischemic or (b) hemorrhagic 3. minimum age 18 4. no significant pre-stroke disability 5. no other stroke in previous 3 months 6. absence of major depression 7. fugl-meyer (fm) motor score of 23-83 out of 100 8. functional independence measure (fim) ambulation-subscore of 3 or more, and 50 foot walk takes longer than 15 seconds exclusion criteria: 1. significant daytime somnolence or any substantial decrease in alertness, language reception, or attention 2. pregnant or lactating 3. advanced liver, kidney, cardiac, or pulmonary disease 4. orthostatic hypotension 5. current use of ciprofloxacin, a centrally acting dopamine agonist, or a centrally active dopamine antagonist 6. a terminal medical diagnosis consistent with survival \< 1 year 7. coexistent major neurological disease 8. coexistent major psychiatric disease 9. a history of significant alcohol or drug abuse in the prior 3 years 10. a coexistent disease characterized by an abnormality of cns dopaminergic tone 11. current enrollment in another investigational study related to stroke or stroke recovery 12. contraindication to ropinirole prescription

Keywords: stroke chronic stroke with hemiparesis
ship-age: frailty, renal function, and multi-component primary care in rural mecklenburg-western pomerania

Conditions: Frailty Syndrome

Summary: chronic kidney disease (ckd) is a leading risk factor for cardiovascular and all-cause mortality among the elderly. mecklenburg-western pomerania has the largest prevalence of ckd in germany and europe. the ckd impact in primary care strategies to reduce frailty syndrome in the elderly is unknown. for this purpose, about 820 elderly participants will be included in an observational study (mv-fit), who will undergo an multi-factorial geriatric assessment, monitoring \& management program, specifically designed to avoid frailty. the goal of the full-scale study is to evaluate the impact of ckd in multi-component primary care strategies to reduce frailty among elderly persons in rural mecklenburg-western pomerania. mv-fit will be conducted on individuals in rural mecklenburg-western pomerania, who will be observed over a period of 3 years. the study of health in pomerania (ship) is a population-based epidemiological, two independent-cohort, study (ship and ship-trend). ship cohorts have been followed for \>24 years. ship/ship tend participants \>60 years or older will studied by a follow-up survey. the aim is to gain new insights into the development of frailty and to develop strategies for keeping those affected healthy.

our study is a longitudinal population-based epidemiological ship-cohort study combined with a prospective, multi-centered, observational/interventional investigation. mv-fit is an observational study of individuals aged 65 years or older with mgfr \>30 ml/min (n=\~820). all participants in the observational/interventional study will receive guideline-based, multi-factorial geriatric assessment, monitoring \& managements (multi-component healthcare). subjects will be stratified by mgfr. objectives are 1) to implement multi-component healthcare specifically comprised of components to reduce frailty and incident falls, 2) to improve compliance and adherence to the multi-component healthcare for frailty and improvement of patient welfare, ability to live independently, quality-of-life, number of falls, referrals to nursing homes, all-cause mortality in primary care of the elderly, 3) to seek the elderly individuals' experience during the course of multi-factorial primary care intervention through in-depth interviews, 4) to clarify the burden of ckd on frailty and health status, and 5) to identify novel risk factors and mechanisms for frailty and pre-frailty. mv-fit data will be corroborated by ship/ship-trend data.

Eligibility criteria:
inclusion criteria: * age 65 years or older * mgfr \> 30 ml/min per 1.73 m2 * being able to understand and give written informed consent. exclusion criteria: * bedridden * palliative * inability to consent * severe dementia * inability to speak * lack of compliance (paracusis, inability to fulfill at least 60% of the assessments)

Keywords: chronic kidney disease frailty falls cognitive decline multi-component interventions rural communities
pre-operative pet-mr of high risk prostate cancer patients for assessment of cancer aggressiveness and lymph node status

Conditions: Prostatic Neoplasms

Summary: prostate cancer is the most frequent cancer in norwegian men. for optimal treatment, accurate staging of the disease at the time point of diagnosis is important. the objective of this study is to evaluate the diagnostic potential of a combined pet/mr examination for risk assessment and detection of lymph node metastases. the overall aim of the project is to improve the investigators ability to provide individually tailored treatment to prostate cancer patients. the study will include 32 men with high-risk prostate cancer, who are eligible for radical prostatectomy. informed consent is a requirement for inclusion in the study.


Eligibility criteria:
inclusion criteria: * high-risk prostate cancer according to eau guidelines (gleason score ≥8 and/or psa ≥20 ng/ml and/or ≥ ct3a cancer) * eligibility for the surgical procedure (radical prostatectomy and bilateral pelvic lymph node resection) exclusion criteria: * previous treatment (for example turp or hormone therapy) * contraindication for the pet/mr examination (including, but not limited to: pacemaker, aneurysm clips, reduced renal function, metal implants, claustrophobia)

Keywords: neoplasm staging positron-emission tomography magnetic resonance imaging 1-amino-3-fluorocyclobutane-1-carboxylic acid
salivary signal molecules for neural and vascular homeostasis in t2dm

Conditions: Type 2 Diabetes

Summary: various signal molecules are detected in blood and tissues of patients with t2dm, that are important for the function of neural tissue in diabetic setting. among them, specifically important are neuroprotective and neurotrophic growth factors such as nerve growth factor (ngf), glial cells - derived neurotrophic factor (gdnf) and brain-derived neurotrophic factor (bdnf). furthermore, several other signal molecules are discovered to affect vascular tissues homeostasis in t2dm, including soluble alpha-klotho (s-klotho), vascular endothelial growth factor (vegf) and interleukin-6 (il-6). most of these molecules are also detected in saliva in various states and diseases of orofacial system, but data about their levels in saliva of t2dm patients are lacking, although neural and vascular diabetic complications are present in orofacial tissues and organs. also, there is no data about presence and levels of s-klotho in saliva of healthy or t2dm patients, although it was reported that this molecule exerts protective effect on the salivary glands tissue. salivary opiorphin is recently discovered pentapeptide, primarily isolated from saliva. it acts as an inhibitor of the enzymes that perform degradation of endogenous antinociceptive molecules enkephalins, affecting nociceptive signal transduction. this may be of special importance since some intraoral complications of t2dm (e.g. burning mouth) may have underlying peripheral neural changes as a pathophysiological mechanism. against this background, the aim of the study is to detect the presence and levels of mentioned signal molecules in saliva of patients with and without t2dm.


Eligibility criteria:
inclusion criteria: * patients with maxillary and mandibular total edentulism with and without t2dm * for patients with t2dm - presence of controlled t2dm exclusion criteria: * presence of the acute pain or swelling in orofacial region * antibiotic therapy up to three weeks prior to study start * conditions or diseases that affect the function of salivary glands (e.g. sjogren syndrome) * radiotherapy of the orofacial region * tobacco smokers * alcohol and/or drug abuse
rationale and analysis of the use of etdno in the treatment of pipj flexion contracture:

Conditions: Flexion Contracture of Proximal Interphalangeal Joint; Joint Deformities, Acquired

Summary: introduction: flexion contracture is one of the most frequent complications in finger trauma. the use of orthoses to obtain the best total end range time (tert) is the most popular method to treat this pathology . until now, no orthosis applied for longer than 3 weeks had been able to achieve tert longer than 12 hours. purpose of the study: to assess whether the elastic tension digital neoprene orthosis (etdno), using a serial dynamic program, can achieve a better result in rom and tert than other orthoses described in the literature. methods: analysis of outcomes in a sample of 30 patients with pip joint flexion contracture treated with the etdno and serial dynamic program.

in this study the researcher will compare the efect of daily tert treatment on the proximal interphalangeal joint contracture using an etdno. the investigator will treat two different groups one with a dose of from 11 to 13 hours of the etdno while the other one is treated with a dose of from 20 to 22 hours of daily tert with the same device. this treatment will last three weeks and will be evalauted the first day, the he first week and the third week. at the end of the study the researcher will quantify the improvement on both groups to know which dailytert dose is the best option.

Eligibility criteria:
inclusion criteria: * pip flexion contracture exclusion criteria: * more than 6 month of contracture and more than 45º of flexion contracture
prevalence of gastric inlet patches of the cervical esophagus.

Conditions: Association of Heterotopic Gastric Mucosa of the Cervical Esophagus and Globus Sensations

Summary: as known from several observational and retrospective endoscopic studies the prevalence of gastric inlet patches (gips) of the cervical esophagus is estimated between 1-10%. in most cases gips are found within endoscopy as an incident finding, since in most cases they are harmless and do not cause any symptoms. none the less several data exist where an association between gips and globus sensations is discussed. case reports even refer to bleeding complications and moreover to malignant transformations of gips. as a result of the assumed association of gips and globus sensations we performed a pilot trial. here we included 10 patients with globus and gips and were able to demonstrate a significant symptom relief after ablation of the gip (meining et al, endoscopy 2006). to exclude a potential placebo-effect we concluded a multicenter and sham controlled trial where we imposingly were able to prove the symptom relief after ablation of the gips (bajbouj et al, gastroenterology 2009). all patients, who are scheduled for esophagogastroduodenoscopy (egd) in any of the above mentioned endoscopical departments are routinely standardized asked whether they have any hints suggestive for globus sensations (modified globus-questionnaire from deary et al., j psychosom res 1995). concurrently it is noted, whether the patients have endoscopical detected gip. all gips are biopsied and examined in one institute. together with anamnestic data (age, gender) a talley sheet gives a survey of all relevant information to prove or disprove following hypotheses. study hypotheses: 1. the presence of gips is associated with globus sensations. in other words: do patients with globus sensations significantly more often have gips? 2. gips are not congenital, they arise in the course of the time and become symptomatic. in other words: do gips significantly occur in more elderly people? 3. the more increased the gips diameter is the more likely globus sensations are present? in other words: do huge gips cause significantly more often symptoms than small ones? 4. the more mucus-producing mucosa is histologically proven the more likely globus sensations are present? in other words: do we find more cardiac mucosa in patients with symptoms than fundus mucosa?


Eligibility criteria:
exclusion criteria: * emergency egd * any condition which contraindicates biopsy sampling * unavailable informed consent for the gd

Keywords: gastric inlet patch prevalence globus sensations
maxillary nerve blocks in children - an mri study of the suprazygomatic approach

Conditions: Nerve Block; Cleft Palate; Analgesia

Summary: ultrasound-guided suprazygomatic maxillary nerve block (smnb) will be performed in paediatric patients with or without the aid of ultrasound guidance. magnetic resonance imaging (mri) is used to visualize the spread of the local anaesthetic (la) spread after suprazygomatic injection and to verify la contact with the maxillary nerve in the pterygopalatine fossa (ppf).


Eligibility criteria:
inclusion criteria: * paediatric patients scheduled for cleft palate (cp) surgery with smnb as part of their perioperative pain treatment * american society of anesthesiologists physical status 1 - 2 * age 10 to 24 months * given informed written consent by legal guardian exclusion criteria: * american society of anesthesiologists physical status \> 2 * patients with cranial deformation * patients with concomitant medical treatments or medical conditions interfering with peripheral nerve block treatment * patients with concomitant medical treatments or medical conditions interfering with mri * patients that are allergic to bupivacaine or other local anaesthetic agents.
dc vaccine therapy combined with cytokine-induced killer cell in treating patients with renal cell carcinoma

Conditions: Renal Cell Carcinoma

Summary: the purpose of this study is to show if vaccination with autologous dendritic cells pulsed with tumor lysate in combination with cytokine-induced killer cell (cik) can induce a measurable immune response in patients with renal cell carcinoma, and to evaluate the clinical effect of the regimen.

the purpose of this study is to show if vaccination with autologous dendritic cells pulsed with tumor lysate in combination with cytokine-induced killer cell (cik) can induce a measurable immune response in patients with renal cell carcinoma, and to evaluate the clinical effect of the regime. primary 1. determine the clinical responses(objective response, progression-free survival, and overall survival) in patients with renal cell carcinoma treated with autologous dendritic cells (dc) loaded with autologous tumor lysate (dc vaccine) in combination with cytokine-induced killer cell (cik). secondary 1. determine cellular immune response response in terms of immuknow assay, and correlate immune response with objective clinical response in patients treated with this regimen. 2. determine safety of multiple administrations of this regimens in these patients.

Eligibility criteria:
inclusion criteria: * histologically proven renal cell carcinoma * age: \> 18 * who- ecog performance status 0-1 * at least one measurable tumor lesions according to the recist criteria. * life expectancy more than 3 months * written informed consent exclusion criteria: * patients with a history of any other neoplastic disease less than 5 years ago (excepting treated carcinomas in situ of the cervix and basal/squamous cell carcinomas of the skin). * patients with metastatic disease in the central nervous system (cns). * patients with other significant illness including severe allergy, asthma, angina pectoris or congestive heart failure. * patients with acute or chronic infection including hiv. * patients who are pregnant or nursing. * patients who have received antineoplastic therapy including chemotherapy or immunotherapy less than 4 weeks before beginning the trial. * patients who receive corticosteroids or other immunosuppressive agents. * patients with active autoimmune diseases such as lupus erythematosus, rheumatoid arthritis or thyroiditis.

Keywords: autologous cytokine induced killer cells dendritic cell vaccine renal cell carcinoma
intubation on a paediatric manikin by emergency staff: a comparison of airtraq and glidescope

Conditions: Difficult Intubation

Summary: after local human research ethics committee approval, emergency medical staff enrolled in this study. after watching a video about the intubation using airtraq, glidescope or direct laryngoscopy, they attempted to intubate a pediatric manikin in three different airway models.

after local human research ethics committee approval, emergency medical staff enrolled in this study. after watching a video about the intubation using airtraq , glidescope or direct laryngoscopy, they attempted to intubate a pediatric manikin in three different airway models; normal airway, tongue edema and an entrapped model by face-to-face approach. intubation attempts, insertion and intubation times, success rates, cormack-lehane grades and the need for maneuvers of these devices were recorded.

Eligibility criteria:
inclusion criteria: * pediatric exclusion criteria: * adult

Keywords: airtraq glidescope pediatric face-to-face
evaluation of the effectiveness of m-dakbas on foot care

Conditions: Diabetic Foot; Foot Ulcer, Diabetic; Health Knowledge, Attitudes, Practice

Summary: aim: to develop the mobile diabetic foot personal care system (m-dakbas) related to foot care for diabetic individuals and to evaluate its effectiveness. method: the study involved 88 patients who applied to the diabetes polyclinic (intervention=44; control=44). while the intervention group used m-dakbas (for 6 months), the control group was provided with a verbal foot care training once, as a standardized procedure of the hospital. data were collected using the "socio-demographic form", "diabetic foot knowledge form - dfkf", "foot self care behaviours scale -fscbs", "diabetic foot care self efficacy scale - dfcses", and "m-dakbas assessment form".

diabetic foot, one of the important complications of diabetes, is a health problem that affects quality of life in a negative way, that has high treatment and care costs and mortality rates, long hospitalization duration and thus with all these aspects a psychological, physical, social and economic priority. despite all these, diabetic foot complications and amputations could be decreased with the help of a good foot care, education and a multidisciplinary team work. mobile technologies have been continuously increasing worldwide for the management of diabetes, and the use of these technologies is recommended by international institutions as well. therefore, the purpose of this study is to develop a turkish mobile application that would increase patients' knowledge levels about foot health and care, improve their behaviours and self-efficacy, and evaluate its effectiveness so that it could be possible to prevent foot ulcer and the related amputations in individuals with diabetes. the mobile diabetic foot personal care system (m-dakbas) developed for this purpose enables to increase individuals' self-confidence, improve communication with the health personnel, involve patients in their own care in an interactive way, and take responsibility. the usability of the application was indicated by the patients' feedback, and in line with the purpose of the mobile application, improvements in the patients' knowledge, behaviours and self-efficacy about foot care in diabetes.

Eligibility criteria:
inclusion criteria: * having a diagnosis history of \>1 year; * having type 1 or type 2 diabetes; * having a mobile phone with android or ios operating system; exclusion criteria: * having visual impairment, * hand skill problem, difficulty in communication, or mental insufficiency; * currently having foot ulcer.

Keywords: diabetic foot health technology mobile application