Kornimate/medical-research-clean huggingface dataset:
intelligent diagnosis and treatment system for pelvic floor dysfunction in elderly women

Conditions: Pelvic Organ Prolapse; Urinary Incontinence; Diagnosis

Summary: the aim of this study is to propose an intelligent diagnosis and treatment system for for pelvic floor dysfunction in elderly women. the main question it aims to answer: 1) how can the investigators find out early if older women have different pelvic floor muscle functions? 2）how can the investigators give personalized treatment plans based on differences in pelvic floor function? participants will be assigned different training programs by the system. the investigators will compare the treatment effects and costs of older women with pelvic floor dysfunction using and not using the system. all the participants will be offered examinations for pelvic floor function and different treatments. all examinations and treatments are non-invasive.


Eligibility criteria:
inclusion criteria: - women over 60 years old. exclusion criteria: * severe pelvic organ prolapse (pop-q stage\>iii) * history of pelvic floor surgery * malignant tumor in pelvic * allergic to nickel * acute inflammation of pelvic or genital tract * subjects who has cognitive impairment and cannot sign an informed consent

Keywords: urinary incontinence pelvic floor muscle intelligent diagnosis and treatment system elderly female pelvic floor dysfunction
pemoline in the treatment of stimulant dependence - 5

Conditions: Cocaine-Related Disorders

Summary: the purpose of this study is to assess the efficacy of pemoline in treating cocaine and/or methamphetamine dependent adults with comorbid adult attention deficit hyperactivity disorder (adhd).


Eligibility criteria:
inclusion criteria: m/f ages 21-50. meet dsm-iv criteria for cocaine dependence. agree to conditions of the study and sign informed consent. exclusion criteria: psychiatric disorder that requires medication therapy. history of seizures. pregnant and/or nuring women. dependence on etoh or benzodiazepines or other sedative/hypnotics. acute hepatitis. other medical condtions that deem participation to be unsafe.

Keywords: cocaine dependence
a clinical study of tranilast in the treatment of cryopyrin-associated periodic syndrome (caps)

Conditions: Cryopyrin-Associated Periodic Syndromes

Summary: this is a prospective cohort study to observe the efficacy and safety of tranilast in caps patients. the investigators would analyze the changes in auto-inflammatory diseases activity index (aidai) before and after treatment as well as changes in inflammatory markers, patients' and physician's global assessment of disease activity to determine the efficacy and safety of tranilast.

seventy-one patients with caps will be recruited. after signing the informed consent, they will be administrated with tranilast (for juvenile patients, 5mg/kg.d with a maximum dose of 0.3g per day; for adult patients, the dose is 0.1g each time, three times a day). these patients will be followed up for 6 months. aidai is recorded by patients' or their parents one month before the start of treatment, and at the 1st, 3rd and 6th month after the treatment. inflammatory markers, and patients' and physician's global assessment of disease activity will be assessed during the 1st, 3rd and 6th month follow-up. side effects will be monitored and recorded as well. experimental data before and after the administration of tranilast will be analyzed and be statistically processed, to figure out whether tranilast is effective and safe for caps patients.

Eligibility criteria:
inclusion criteria: * all patients must meet the following diagnostic criteria of caps and have pathogenic mutation(s) in nlrp3 gene. 1. raised inflammatory markers (crp/saa) (mandatory criteria) 2. ≥2 of 6 caps typical signs/symptoms: 1. urticaria-like rash; 2. cold/stress triggered episodes; 3. sensorineural hearing loss; 4. musculoskeletal symptoms (arthralgia/arthritis/myalgia); 5. chronic aseptic meningitis; 6. skeletal abnormalities (epiphyseal overgrowth/frontal bossing). exclusion criteria: * patients will not be included if meets any of the following criteria: 1. being treated with il-1 inhibitor, other biological agents and immunosuppressants 2. pregnant and lactating women 3. serious organ function failure, expected life time less than 6 months

Keywords: cryopyrin-associated periodic syndromes tranilast efficacy safety
comparison of two sedation versus placebo techniques during cataract surgery under local anesthesia

Conditions: Sedation; Cataract

Summary: check the sedation conditions during topic cataract surgery


Eligibility criteria:
inclusion criteria: * topic cataract surgery exclusion criteria: * na
docetaxel in node positive adjuvant breast cancer

Conditions: Breast Cancer

Summary: the purpose of this study was to compare disease-free survival after treatment with docetaxel in combination with doxorubicin and cyclophosphamide to 5-fluorouracil in combination with doxorubicin and cyclophosphamide in operable breast cancer patients with positive axillary lymph nodes.

in addition to the 5-year analysis conducted in september 2003, two other analyses were planned when 590 and 700 disease free survival events occurred. however, due to the lower than predicted dfs event rate, and in agreement with fda and ema, a time-based final analysis at 10 years was considered more appropriate than an event-based (700 disease free survival events) analysis.

Eligibility criteria:
inclusion criteria: * histologically proven breast cancer (invasive adenocarcinoma with at least one axillary lymph node showing evidence of tumor among a minimum of six resected lymph nodes). * definitive surgical treatment must be either mastectomy, or breast conserving surgery with axillary lymph node dissection for operable breast cancer. margins of resected specimen from definitive surgery must be histologically free of invasive adenocarcinoma and ductal carcinoma. exclusion criteria: * prior systemic anticancer therapy for breast cancer (immunotherapy, hormonotherapy, chemotherapy). * prior anthracycline therapy or taxoids (paclitaxel, docetaxel) for any malignancy.

Keywords: adjuvant treatment
hostile bias modification training online study ii

Conditions: Aggression; Anger; Emotion Regulation; Self-Control; Stress

Summary: the purpose of this study is to see how people respond on a word completion task relates to how they behave and respond to situations in the real world. this is a two part research study. at time-point one, participants will fill out some brief personality surveys. they will also read several short scenarios and imagine how they would react and/or interpret these situations in real life. they will also complete a vocabulary task where they will sort word fragments based on type as quickly as they are able. participants will be asked to return in 24-96 hours for part two where they will repeat a similar scenario reading activity as during time one and fill out a brief questionnaire about your recent behaviors.


Eligibility criteria:
inclusion criteria: 1. adult aged 18 and older 2. located in the united states or other primarily english speaking country. 3. active amazon account. exclusion criteria: * less than 18 years old. * not located in the united states or other primarily english speaking country.

Keywords: attention bias hostile attribution bias hostile bias modification
pmp-300e (smart watch): portable monitoring device study

Conditions: Obstructive Sleep Apnea

Summary: validation of portable monitoring device pmp-300e for identification of obstructive sleep apnea.

the purpose of the study is to validate an obstructive sleep apnea portable monitoring device, pmp-300e. validating process compared data collected by pmp-300e with data collected from in-lab polysomnography.

Eligibility criteria:
inclusion criteria:inclusion criteria: * age 18 and over. * require a sleep diagnostic study by physician's order. * able and willing to provide written informed consent. * able to speak and read english. exclusion criteria:exclusion criteria: * participation in another interventional research study within the last 30 days. * unstable medical or psychiatric conditions that would interfere with the demands of the study or the ability to commit to follow-up assessment. examples include unstable congestive heart failure, neuromuscular disease, cancer, and renal failure. * chronic respiratory failure or insufficiency with suspected or known neuromuscular disease, moderate or severe copd or other pulmonary disorders, or any condition with an elevation of arterial carbon dioxide levels (\> 45 mmhg) while awake or participants qualifying for oxygen therapy (arterial saturation 88% for more than five minutes). * consumption of ethanol more than 4 nights per week. (cage criteria) * use of recreational drug within the past 12 months. * women who are pregnant or currently lactating.
changes in intra-articular parameters by doppler ultrasound in patients with hemophilic ankle arthropathy

Conditions: Hemophilia

Summary: introduction: hemophilic ankle arthropathy is manifested by functional degenerative alterations, intra-articular alterations, and chronic pain. manual therapy techniques are used in the treatment of hemophilic ankle arthropathy for the improvement of pain and mobility. design. double-blind randomized pilot trial. aimed: to evaluate the ultrasound changes by means of doppler imaging after manual therapy intervention. patients: a total of 20 adult patients with hemophilic ankle arthropathy will be recruited. intervention: each manual therapy session will last approximately 50 minutes, with 1 session per week for a period of 3 weeks. the treatment program includes 10 techniques that will be administered bilaterally. measuring instruments: patients will be evaluated qualitatively with ultrasound (head-us scale) and assessment with doppler ultrasound. the clinical variables will be joint damage (hemophilia joint health score) and pain intensity (visual analogue scale). expected results: check the safety of manual therapy in patients with hemophilia regarding subclinical bleeding. assess changes related to joint inflammatory state with imaging techniques. observe changes in pain intensity and joint damage.


Eligibility criteria:
inclusion criteria: * patients diagnosed with hemophilia a or b. * persons over 18 years of age. * patients with a medical diagnosis of ankle arthropathy (with clinical assessment of more than 4 points on the hemophilia joint health score. * patients on prophylactic or on-demand treatment with fviii / fix concentrates. * sign the informed consent document. exclusion criteria: * patients with inhibitors (antibodies against fviii or fix) without treatment with monoclonal antibodies. * patients with neurological or cognitive alterations that impede the comprehension of questionnaires and physical tests. * patients who have developed an ankle hemarthrosis in the 3 months prior to the study. * patients who at the time of the study are receiving ankle physiotherapy treatment.

Keywords: hemophilia ankle manual therapy ultrasound joint pain joint damage
assessment of potential interactions between methamphetamine and bupropion - 1

Conditions: Amphetamine-Related Disorders

Summary: the purpose of this study is to assess potential interactions between intravenous (iv) methamphetamine and oral bupropion.

this is a human laboratory clinical pharmacology study to assess potential interactions between iv methamphetamine challenge and treatment with oral sustained-release bupropion.

Eligibility criteria:
inclusion criteria: please contact site director for more details. exclusion criteria: please contact site director for more details.
the association between the intraoperative blood pressure changes and whole exome genome

Conditions: the Association Between the Arterial Stiffness, Intraoperative Blood Pressure Changes and Genetic Effect

Summary: the intraoperative blood pressure changes have been important for postoperative morbidity and mortality. however, some patients did not occur intraoperative hypotension but some patients would have severe intraoperative hypotension. it may be associated with genome related. in this hypothesis, we aim to elucidate the association between the whole exome genome and intraoperaive blood pressure changes.

we aim to elucidate the association between the whole exome genome and intraoperative blood pressure changes. we will enroll patients older than 20 years old and undergo elective general anesthesia. before anesthesia, we will obtain blood sample for whole exome genome test and give arterial line for intraoperative monitor. after completing surgery, we will follow the patients' all postoperative major organ function. we hope this study to be able to give us the more information about the specific genetic effect on the arterial stiffness and intraoperative blood pressure changes.

Eligibility criteria:
inclusion criteria: * elective general surgery exclusion criteria: * coagulopathy
comparative of effects of sublingual misoprostol and infusion oxytocin in reduction of bleeding at cesarean

Conditions: Bleeding Intraoperative

Summary: the purpose of this study is to determine whether the effect of sublingual misoprostol is better than infusion oxytocin in reduction of blood loss at cesarean deliveries.

a total of 180 pregnant women with gestational age 37 weeks and over who underwent cesarean operation in imam reza hospital had elective or emergency procedure with incision in lower segment during one year recruitment. the patients were randomly assigned to undergo 200 micrograms misoprostol sublingual or 400 micrograms and infusion 20 unit oxytocin after spinal anesthesia. main outcome measures: the length of surgery, bleeding volume, the need for transfusion, fever, tachycardia, and hypotension.

Eligibility criteria:
inclusion criteria: * indication of cesarean deliveries * elective or emergency with incision in lower segment in women with * gestational age more than 37 weeks. exclusion criteria: * anemia * multiple pregnancy * polyhydraminus * prolonged labor * premature rupture of membrane and patients had previous history of diabetes mellitus * hypertension * cardiovascular disease * coagulopathy disease

Keywords: misoprostol oxytocin cesarean delivery blood loss
effects of brain network by simultaneous dual-mode stimulation in subacute stroke patients

Conditions: Stroke; Motor Disorder

Summary: repetitive transcranial magnetic stimulation (rtms) or transcranial direct current stimulation (tdcs) has been used for the modulation of stroke patients' motor function by altering the cortical excitability. recently, more challenging approaches, such as stimulation of two or more sites or use of dual modality have been studied in stroke patients. in this study, simultaneous stimulation using both rtms and tdcs (dual-mode stimulation) over bilateral primary motor cortices (m1s) was investigated to compare its modulatory effects with single rtms stimulation in subacute stroke patients.

investigators assessed each patient's motor function using the fugl-meyer assessment (fma) score and acquired their resting-state fmri (rs-fmri) data at two times: prior to stimulation and 2 months after stimulation. changes in rs-fmri network measures were investigated between groups.

Eligibility criteria:
inclusion criteria: * first-ever stroke patients * subacute stage (less than 4 weeks) * total fugl-meyer assessment (fma) score under 84 exclusion criteria: * major active neurological disease or psychiatric disease * a history of seizure * metallic implants in their brain

Keywords: motor network resting-state fmri repetitive transcranial magnetic stimulation transcranial direct current stimulation
prevention of cardiovascular disease and mortality in patients with psoriasis or psoriatic arthritis

Conditions: Psoriasis; Psoriatic Arthritis; Psoriatic Conditions; Cardiovascular Diseases

Summary: the goal of this research is to test a novel centralized care coordinator program to assist patients with psoriatic disease in lowering their risk of cardiovascular disease through the application of standard of care approaches to improving modifiable cardiovascular risk factors.

psoriasis patients have an increased risk of cardiovascular disease and mortality but are less likely to have traditional cardiovascular risk factors identified or adequately managed. care coordinators have previously been demonstrated to improve outcomes in patients with chronic diseases (such as comorbid diabetes and depression) and are now routinely embedded in primary care practices in integrated health systems. the goal of this research is to test a novel centralized care coordinator program to assist patients with psoriatic disease in lowering their risk of cardiovascular disease through the application of standard of care approaches to improving modifiable cardiovascular risk factors.

Eligibility criteria:
inclusion criteria: 1. willing and able to provide informed consent 2. male or female aged 40-75 3. being seen by a dermatology provider in routine care for the primary encounter diagnosis of psoriasis exclusion criteria: 1. currently taking a prescription lipid lowering medication 2. pregnant or planning pregnancy in the next 6 months 3. has a known history of cardiovascular disease (mi, stroke, coronary artery, cerebrovascular, or peripheral vascular disease)
prophylactic peritoneal dialysis decreases time to achieve a negative fluid balance after the norwood procedure

Conditions: Hypoplastic Left Heart Syndrome

Summary: babies born with hypoplastic left heart syndrome (hlhs) have three separate, complex heart surgeries before they turn three years of age. the first surgery typically happens in the first two weeks of life. after this operation, babies come back to the intensive care unit with their chests open. babies who have heart surgery retain body water after surgery and this extra water slows recovery. surgeons cannot close the chest until the baby gets rid of the extra water. as a result, babies have to stay in the intensive care unit and on a breathing machine for longer. peritoneal dialysis, also known as pd, involves placing a small catheter into the belly cavity at the time of surgery. pd helps the kidney to get rid of extra body water. pd involves putting small amounts of special fluid into the belly through the catheter. this special fluid attracts water and is drained hourly. by allowing the belly cavity to drain, this helps both the heart and the lungs. this allows the chest to be closed and the breathing tube to be removed. the investigators are looking to see how quickly the babies, with and without pd, get rid of the extra water in turn shortening their stay in the intensive care unit and in the hospital. pd is not permanent, and only used for the first few days after the operation.


Eligibility criteria:
inclusion criteria: * infants with hlhs or its variants who have a norwood procedure * parental consent exclusion criteria: * premature neonates less than 37 weeks gestation * weight less than 2 kg * urine output less than 0.5ml/kg/hr over 24 hours in the 48 hours prior to the norwood * pre-operative renal replacement therapy * abdominal defects precluding placement of a pd catheter * known chromosomal abnormality * pre-operative cardiopulmonary resuscitation (cpr) * pre-operative extra-corporeal life support (ecls)
the proximal contact tightness and location in class ii composite restorations

Conditions: Tooth Decay

Summary: this study aims to investigate consecutive biological changes in proximal contact tightness using digital force gauge and evaluate proximal contact location using cone beam computed tomography between class ii direct composite restorations and adjacent teeth after using sectional matrix system and with different contact forming instruments.


Eligibility criteria:
inclusion criteria: * presence of proximal caries in cbct x-ray with score 3 to 4 according to the radiographic international caries detection and assessment system (icdas). * presence of the antagonist and the adjacent tooth making contact. * the teeth to be restored had to show no signs of pulpitis but positive sensitivity using endo ice testing. * size of the isthmus with no more than 2/3 of the intercuspal distance * good oral health and absence of periodontal disease * patients who are not suffering from severe systemic diseases or allergies exclusion criteria: * medically compromised patients * clinical signs of bruxism, traumatic malocclusion * pregnant or breast feeding at the time of restoration placement * intolerance or allergy toward the applied restorative materials
comparison of conservative and operative treatment of jones fracture

Conditions: Fracture of Fifth Metatarsal Bone

Summary: the study deals with the topic of treatment of jones fracture, comparing surgical and conservative approach. the fracture occurs especially in highly active individuals.

the study deals with the topic of treatment of jones fracture, comparing surgical and conservative approach. the fracture occurs especially in highly active individuals. the study proposes a supposition of recommending the active operational approach, which shortens the period of healing by 6 weeks, limitation of physical activity by 4 weeks, and sick leave by 2 months. it also completely eliminates the need to perform a rigid fixation of the extremity for 8-12 weeks.

Eligibility criteria:
inclusion criteria: - jones fracture exclusion criteria: * combined injury * recurring injury * diabetes mellitus * chronic renal insufficiency * osteopathy

Keywords: jones fracture the american orthopaedic foot & ankle society (aofas) herbert screw
adjuvant antigen specific immunotherapy in patients with advanced renal cell carcinoma using tumor associated peptides

Conditions: Renal Cell Cancer; Advanced Renal Cell Cancer

Summary: clinical phase i/ii study to investigate the feasibility and tolerability of synthetic adjuvant peptide immunisation in combination with immune adjuvants (granulocyte macrophage colony stimulating factor; montanide isa-51) in patients with advanced renal cell cancer (rcc).


Eligibility criteria:
inclusion criteria: * advanced renal cell carcinoma clinical stage t3 or t4, n0, m0 * n+, m0 * m1 (after complete metastasectomy) * ecog performance status 0 or 1 * age \>18 years * at least 4 weeks since last administration of radiation- or chemotherapy * serum levels of bilirubin \<2 mg/dl, creatinine\<2mg/dl exclusion criteria: * detectable distant metastasis in radiological imaging (m1) * patients unable to consent * severe cardiopulmonary disorder (nyha \>= 3) * presence of secondary malignancy * immunosuppressive medication (last application of glucocorticoids \> 4 weeks) * seizure * pregnancy * simultaneous participation in other active or passive immunisation treatment