Kornimate/medical-research-clean huggingface dataset:
measuring the impact of an enhanced strategy for daily disinfection in acute care hospital rooms

Conditions: Disinfection

Summary: to determine the effectiveness of an enhanced strategy for daily disinfection in acute care hospital rooms comparing the addition of sani24 to routine daily cleaning versus the control of routine daily cleaning.

the study investigator will evaluate the effectiveness of a) adding sani24 to the standard daily cleaning and b) routine daily disinfection in acute care hospital rooms to measure the reduction in bioburden. in other words, the study aims to answer the following research question: does the addition of an additional disinfection technology (sani24) decrease the environmental bioburden in inpatient hospital compared to routine disinfection? this trial was conducted in acute care hospital rooms at duke university hospital in durham, north carolina from november 2021 to march 2022. room surfaces were divided in two (e.g., right vs. left), allowing each patient room to serve as its own control. the intervention was a quaternary ammonium salt-based 24-hour continuously active germicidal wipe, sani-24 (pdi healthcare, woodcliff, nj) that was applied in addition to routine disinfection. the control arm received no intervention beyond routine disinfection. environmental services were blinded to study arms and no changes to routine cleaning protocols occurred during the study period. room contamination was measured immediately before the application of the disinfectant (study day 0) and 24-hours later (day 1). secondary outcomes included evaluation for clinically important pathogens (cip), including methicillin-resistant staphylococcus aureus (mrsa), vancomycin-resistant enterococcus (vre) and carbapenem-resistant enterobacteriaceae (cre)

Eligibility criteria:
inclusion criteria: * inpatient rooms housing adult patients on contact precautions exclusion criteria: -

Keywords: disinfection, contamination
myproms-es02: safety and efficacy of basiliximab, cyclosporine microemulsion and enteric-coated mycophenolate sodium (ec-mps) versus ec-mps and steroid therapy in kidney transplant recipients who are hepatitis c positive

Conditions: De Novo Kidney Transplant

Summary: to prospectively evaluate in de novo kidney transplant recipients, hepatitis c positive, the clinical outcomes of an immunosuppressive regimen of ec-mps free of steroids in comparison with a regimen of ec-mps with standard steroids, as measured by the hepatic function tests (alt/ast) after 12 months treatment.


Eligibility criteria:
inclusion criteria 1. patients hepatitis c positive (serology test within the last 12 months and determined by third-generation assay). 2. recipients of heart-beating cadaveric, living unrelated or living related non-hla identical donor kidney transplant, treated with basiliximab and csa-me as primary immunosuppression. exclusion criteria 1. multi-organ recipients (e.g. double kidney, kidney and pancreas or kidney and liver) or previous transplant with any other organ. 2. kidneys from non-heart beating donors. 3. abo incompatibility against the donor. 4. patients with panel reactive antibodies of \>50% at most recent assessment prior to transplantation and /or prior graft lost due to immunological reasons in the first six months post-transplantation or patients who are considered to be at increased risk of acute rejection by the principal investigator additional protocol defined inclusion/exclusion criteria may apply.

Keywords: kidney transplant, hepatitis c, enteric-coated mycophenolate sodium
women underwent tram surgery: its influence on abdominal muscle function and the effects of therapeutic exercises

Conditions: Breast Neoplasms

Summary: the unilateral transverse rectus abdominis musculocutaneous (tram) flap is a major operation widely used for breast reconstruction. it is hypothesized that this surgery has the potential risk of weakening the abdominal wall because it disrupts the integrity of the rectus abdominis muscle (ra), therefore, alters the insertion of the oblique muscles and the biomechanical relationship between the ra muscle and adjacent structures. the purposes of this study were to examine the effects of the tram flap surgery on muscle size of abdominal muscles, strength and endurance of trunk muscles, strength and endurance of core stability, as well as the effects of therapeutic exercises on it in post-mastectomy women underwent tram surgery.

this first year of the proposed study was aimed to understand the impacts on abdominal muscle functions. we design a case-control, cross-sectional study. there were 46 women who have undergone tram flap and 36 age-matched healthy women. we recorded the biomechanic and electromyographic responses during voluntary limb movements and elicited by unexpected support surface translations and tilts in standing. a six-camera qualisys motion system was used. ground reaction forces and moments were acquired by one kisler force plate. surface electromyography electrodes were used to record the activity of selected trunk and limb muscles. the second year was aimed to evaluate the effects on abdominal muscle functions after 12 weeks abdominal muscle training in the tram women. outcome measures were the clinical tests for trunk muscle strength, endurance and one-leg standing was also used to exam the abdominal muscle function.

Eligibility criteria:
inclusion criteria: 1. healthy adults * their age should be ranged between 30 - 60 years 2. tram flap surgery patients * at least 6 months after the ms pedicled tram flap surgery exclusion criteria: 1. healthy adults * a history of injury resulting in an inability to perform activities of daily living * scoliosis or spinal surgery * neurological, neuromuscular, rheumatological or systemic diseases 2. tram flap surgery patients * tumor distant metastasis * a history of injury resulting in an inability to perform activities of daily living * scoliosis or spinal surgery * neurological, neuromuscular, rheumatological or systemic diseases
evaluation of use of plastic bags to prevent neonatal hypothermia-part ii

Conditions: Hypothermia

Summary: the overall hypothesis is that plastic bags used in combination with who thermoregulation care will reduce the incidence of hypothermia in preterm/low birth weight and full term infants when compared to routine who thermoregulation care alone. part ii is for preterm/low birth weight infant with or without plastic head cover used from 1 hour after birth until discharge or 24 hours after birth to assist with temperature regulation.

due to limited resources, hospitals in the developing world struggle to provide sufficient incubators and to maintain climate-controlled nurseries. therefore, premature low birth weight infants continue to be at an increased risk of hypothermia throughout their hospitalizations. this study will compare the incidence of hypothermia in preterm/low birth weight infants randomized to receive who thermoregulation care (control groups) or who thermoregulation care and a plastic bag covering their torsos and lower extremities (intervention group) starting at one hour after birth and continued to discharge or 24 hours after birth, whichever occurs first. the axillary temperature of each infant will be taken one hour after birth, every subsequent 3-4 hours, and at discharge or 24 hours after birth when infants will be removed from the plastic bags. seizures, hyperthermia, room temperature, and death will be recorded throughout the hospitalization for all infants. with an estimated baseline hypothermia rate of 50% and a hypothesized 20% absolute risk reduction (40% relative risk reduction), a sample size of 182 will be used to have a power of 80% and a confidence interval of 95%.

Eligibility criteria:
inclusion criteria: * estimated gestational age 29-36 6/7 weeks or birth weight 1400-2500g * delivery in the hospital exclusion criteria: * infant admitted to the nicu * birth weight less than 1400 gms * abdominal wall defect or myelomeningocele * major congenital anomalies * blistering skin disorder

Keywords: hypothermia low birth weight newborn plastic bag thermoregulation
dose-ranging study of an ophthalamic solution in patients with loss of visual function due to age-related nuclear cataract

Conditions: Nuclear Cataract

Summary: this study will evaluate the safety and efficacy of three doses of c-kad ophthalmic solution in patients with loss of visual function due to age-related nuclear cataract


Eligibility criteria:
inclusion criteria: * presence of nuclear sclerosis cataract * bcdva within the range of 20/40 and 20/80 exclusion criteria: * any other clinical condition in the eye that may compromise vision * presence or history of glaucoma * presence or history of diabetes * use of eyedrops * use of steroids

Keywords: cataract study ophthalmic study agerelated cataract nuclear cataract low grade nuclear cataracts
the effect of tens application for pain

Conditions: Appendicitis Surgery; Inguinal Surgery

Summary: the aim of the study which was planned in a randomized controlled experimental design, it was aimed to determine the effect of transcutaneous electrical nerve stimulation (tens) application on pain level before mobilization in the postoperative period in children.

children can often experience chronic muscle, bone, joint pain, headache and abdominal pain, and acutely experience pain due to postoperative and procedural procedures. effective management of childhood pain is emphasized as a health priority by the world health organization and pain communities. the findings of various epidemiological studies emphasized that a significant proportion (49% to 64%) of children receiving treatment in a hospital setting received inadequate pain management services despite the increase in available knowledge and treatments. one of the situations in which pediatric patients encounter acute pain is the postoperative period. mobilization is delayed in patients who cannot provide adequate pain control, and accordingly, serious complications such as impaired tissue perfusion, atelectasis and deep vein thrombosis may develop. there are studies on the use of tens, one of the methods used in non-pharmacological pain management, in postoperative pain management in adults. studies on pain management in children for tens application are very limited today. there was no evidence for the effectiveness of tens application applied before mobilization in the postoperative period in children.

Eligibility criteria:
inclusion criteria: * be in the 7-12 age range * abdominal surgery indication (appendicitis or inguinal region surgery) * volunteering to participate in the study * receiving monotherapy treatment for epilepsy * to be able to communicate in turkish exclusion criteria: * administering analgesic therapy other than routine administration * patients who have difficulties in mobilization/complications during the operation will be excluded from the study.

Keywords: transcutaneous electric nerve stimulation child surgery pain
tumor treating fields for newly diagnosed glioblastoma: two emulated trials with chinese multi-hospital based real-world data

Conditions: Glioblastoma Multiforme

Summary: the goal of this observational study is to learn about the effectiveness of optune® (tumor treating fields) in newly diagnosed glioblastoma (gbm) in china. the main question it aims to answer are: * the efficacy of optune® as an concomitant/adjuvant to radiation therapy (rt) and temozolomide (tmz) alone in the treatment of newly diagnosed gbm patients. * the effectiveness of optune® given concomitantly with rt and tmz in newly diagnosed gbm patients, compared to rt and tmz alone. participants will: * receive or not receive ttfields. * concomitantly or adjuvantly receive ttfields.

the goal of this observational study is to learn about the effectiveness of optune® (tumor treating fields) in newly diagnosed glioblastoma (gbm) in china. the main question it aims to answer are: * the efficacy of optune® as an concomitant/adjuvant to radiation therapy (rt) and temozolomide (tmz) alone in the treatment of newly diagnosed gbm patients. * the effectiveness of optune® given concomitantly with rt and tmz in newly diagnosed gbm patients, compared to rt and tmz alone. participants will: step 1: * treatment arm i: patients receive standard rt + tmz, followed by maintenance tmz, with optune® starts during peri-radiotherapy period (2 month before to 3 months after radiotherapy). the duration of ttfields lasts for at least 2 months. * treatment arm ii: patients receive rt and tmz alone, followed by maintenance tmz concomitant. step 2: * treatment arm i: patients receive ttfields at 200 khz to the brain using the optune® system together with rt and tmz, followed by maintenance tmz concomitant with the optune® treatment. the duration of ttfields lasts for at least 2 months. if the subject is assigned to this treatment arm, optune® therapy will begin no later than the 7th day of rt and tmz treatment. * treatment arm ii: patients receive rt and tmz alone, followed by maintenance tmz concomitant with ttfields at 200 khz to the brain using the optune® within 3 months after radiotherapy for at least 2 months. researchers will compare the overall survival of each arm to see if ttfields demonstrates an improvement in survival outcomes within the chinese population in real-world practice, and whether this efficacy is further enhanced when combined with rt and tmz.

Eligibility criteria:
inclusion criteria: 1. histologically confirmed diagnosis of gbm according to who classification criteria. 2. age ≥ 18 years. 3. recovered from maximal debulking surgery. 4. karnofsky performance status ≥ 60. 5. planned treatment with rt/tmz followed by maintenance tmz. exclusion criteria: 1. progressive disease (per investigator's assessment). 2. infratentorial or leptomeningeal disease. 3. significant co-morbidities at baseline which would preclude maintenance rt or tmz treatment. 4. any serious surgical/post-operative condition that may risk the patient according to the investigator.

Keywords: glioblastoma tumor treating fields real-world concomitant adjuvant overall survival
carperitide in acute respiratory distress syndrome (ards)

Conditions: Respiratory Distress Syndrome

Summary: the purpose of this study is to determine whether carperitide is safe and effective in the management of acute respiratory distress syndrome (ards).

acute respiratory distress syndrome (ards is a severe form of acute lung injury. ards is characterized by an increase in pulmonary vascular permeability resulting from a non-cardiogenic cause, leading to an increased vascular water volume, pulmonary inflammation, and severe hypoxemia. conventional therapy for ards is primarily respiratory management by mechanical ventilation using positive end-expiratory pressure (peep). mechanical ventilation is the major management concern in patients with ards, due to its higher risk of infections and morbidity. treatment with carperitide may reduce time on the ventilator by reducing pulmonary edema and by improving gas exchange. the results of carperitide studies in animals and humans support the idea that the hormone will be effective in managing the acute pulmonary complications and hypoxemia seen in ards.

Eligibility criteria:
inclusion: in order to participate in the study, patients must: * be 18 years or older * have an acceptable pf ratio * have adequate fluid volume * be intubated less than 7 days exclusion: in order to participate in the study, patients must not meet any of the following criteria: * be moribund * be immunocompromised * have pneumonia (caused by pneumocystis carinii) * have recieved another investigational drug or device within the last 30 days * have a do not resuscitate order

Keywords: acute respiratory distress acute lung injury
cognitive effects of exercise in parkinson's disease

Conditions: Parkinson Disease

Summary: this pilot study will evaluate the short-term (3 months) and long-term (6 months) effectiveness of a high-intensity interval training (hiit) program in improving cognitive function and self-efficacy in individuals with pd.

participants will be assigned to either the hiit group, which will engage in 3 classes per week, or a standard-of-care control group, which will include people who will continue their standard care and usual physical activities but do not plan on partaking in additional structured exercise interventions for 3 months (except for physical and occupational therapy if medically necessary). cognitive functions will be measured using standardized tests (stroop, trail making test-b (tmt-b), verbal fluency (using letters f-a-s), and repeatable battery for the assessment of neuropsychological status (rbans)), alongside assessing subjective ratings of daily cognitive function using the neuro quality of life - cognitive function (neuro-qol cf) survey. secondary outcomes will include self-efficacy measures, specifically regarding goal achievement, managing emotions and daily activities. we will also aim to obtain brain functional mri (fmri) and neuromelanin-sensitive mri (nm-mri) data from a subset of participants to measure the brain effects of hiit as exploratory outcomes.

Eligibility criteria:
inclusion criteria: * diagnosis of idiopathic parkinson's disease * age 40 year and above * willingness and ability to participate in hiit exercise classes exclusion criteria: * non-english speaking * neuropsychiatric disorder other than parkinson's disease and comorbid depression and anxiety (e.g., stroke, epilepsy, brain tumor, multiple sclerosis, schizophrenia, bipolar disorder, obsessive compulsive disorder, etc.) * high levels of exercise at baseline (exercising at high intensity at least 3 times per week or moderate intensity at least 5 times per week) * hoehn \& yahr disease stage \> 3 (physically not independent)

Keywords: exercise high-intensity interval training cognitive function mri
examining the influence of guided meditation on diabetes-related distress and glycemic control

Conditions: Type 1 Diabetes Mellitus

Summary: the study aims to investigate the effects of guided meditation on diabetes-related distress and glycemic control in hospitalized type 1 adolescent diabetic patients. the study will employ a randomized controlled trial design, with participants randomly assigned to either the intervention group (receiving guided meditation sessions) or the control group (receiving standard care). the primary outcomes measured will be diabetes-related distress levels and glycemic control (hba1c levels).

the researchers hypothesize that the intervention group will experience a reduction in diabetes-related distress and an improvement in glycemic control compared to the control group. the study's findings could suggest how guided meditation could help manage the emotional distress and enhance diabetes management in hospitalized type 1 adolescent diabetic patients.

Eligibility criteria:
inclusion criteria: * adolescent patients aged between 12 to 18 years. * confirmed diagnosis of type 1 diabetes mellitus. * hospitalized in the participating medical facility. * capable of providing informed consent (for participants aged 18) or providing assent with parental/legal guardian consent (for participants aged 12 to 17). exclusion criteria: * presence of severe psychiatric disorders or cognitive impairments that may hinder participation in the guided meditation sessions. * physical limitations or medical conditions that prevent the safe participation in the intervention or assessment procedures. * previously engaged in regular meditation or mindfulness practices, which may confound the results. * inability to communicate effectively in the language used for assessments and interventions.

Keywords: type 1 diabetes mellitus guided meditation adolescents
diethylhomospermine (dehspm) for refractory aids-related diarrhea

Conditions: Diarrhea; HIV Infections

Summary: to perform preliminary clinical testing of diethylhomospermine (dehspm), a polyamine analogue, for refractory aids-related diarrhea. possibly, dehspm will reduce stool volume and frequency in patients with refractory aids-related diarrhea.

possibly, dehspm will reduce stool volume and frequency in patients with refractory aids-related diarrhea. patients are initially hydrated for 24 hours, followed by a 3-day baseline period. they then receive intravenous infusions of dehspm three times per day for 3 days, followed by observation for 3 days.

Eligibility criteria:
inclusion criteria patients must have: * arc or aids by cdc criteria. * uncontrolled diarrhea unresponsive to high-dose, nonspecific antidiarrheal therapy. exclusion criteria co-existing condition: patients with the following symptoms or conditions are excluded: * known idiopathic ulcerative colitis or crohn colitis. * acute stool-culture-positive bacterial colitis. * acute amoebic colitis. * pseudomembranous colitis with clostridium difficile toxin positivity. * short-gut syndrome. * chronic pancreatitis. * ischemic bowel disease. * enteroenteric fistulae. * other gastrointestinal tract disorders known to cause diarrhea. * underlying evidence of immunosuppression other than that related to hiv infection. * unable or unwilling to have subcutaneous injections. * clinically significant cns, hepatic, or renal disease. concurrent medication: excluded: * other experimental antidiarrheal drugs. * antibiotic therapy. prior medication: excluded: * other experimental drugs within 1 month prior to study entry. required: * at least 2 weeks of prior high-dose, nonspecific antidiarrheal therapy (i.e., loperamide, diphenoxylate hydrochloride-atropine sulfate, or opiates) at maximally tolerable doses.

Keywords: antidiarrheals diarrhea acquired immunodeficiency syndrome aids-related complex n(1),n(14)-bis(ethyl)homospermine
inhaled iav vs inhaled eucalyptus for the treatment of nausea with acute migraine

Conditions: Migraine

Summary: the goal of this study is to compare the efficacy and adverse events of inhaled isopropyl alcohol vapor (iav) versus placebo (inhaled eucalyptus scent (ies) (1:20 dilution in mineral oil) for treating nausea associated with acute migraine attacks.

the main goal of this study is to examine the efficacy of (nausea reduction and time to use of other anti-nausea medications) and side effects of inhaled isopropyl alcohol vapor (iav) for treating nausea among migraine patients using a double blind randomized control methodology. iav is being compared inhaled eucalyptus scent (ies) (1:20 dilution in mineral oil) which has not shown benefit for treating nausea or migraine and is therefore considered placebo in this study.

Eligibility criteria:
inclusion criteria: * patients 18 to 65 years old with nausea associated migraines at least twice per month exclusion criteria: * patients \ 65 years old * patients without a diagnosis of acute migraine

Keywords: nausea isopropyl alcohol eucalyptus aromatherapy vapors
ventricular rate regularization for improved quality of life in patients with chf and af

Conditions: Congestive Heart Failure; Atrial Fibrillation

Summary: single center investigator initiated sponsored by guidant boston scientific corp. to evaluate the benefit of ventricular rate regularization (vrr) in patients with congestive heart failure (chf) and significant atrial fibrillation (af) burden.


Eligibility criteria:
inclusion criteria: * be between 18-85 years old * be willing and able to give informed consent * patient currently has a crt-d or icd with \> 20% atrial fibrillation burden as recorded by defibrillator follow up report or a history of atrial fibrillation prior to implant. * patient has the ability to complete a six minute walk test with the only limiting factors to be fatigue or shortness of breath. exclusion criteria: * expected mortality less than 6 months due to non-cardiac causes. * pregnant women. * creatinine greater than or equal to 2.5 mg/dl. * anemia (hct less than 30) * copd causing significant dyspnea * orthopedic problems affecting 6 minute walk.

Keywords: atrial fibrillation icd biv icd chf congestive heart failure af