Kornimate/medical-research-clean huggingface dataset:
establishment of multiparametric prediction models for moderate to severethyroid associated ophthalmopathy

Conditions: Thyroid Associated Ophthalmopathy

Summary: thyroid-associated ophthalmopathy (tao) is an organ-specific autoimmune disease closely related to thyroid disease, which leads the incidence of orbital disease in adults and is the most common cause of diffuse toxic goiter (graves disease, gd). the clinical manifestations of tao are complex and varied. in severe cases, it may seriously impair visual function, affect daily life, and even cause corneal ulceration, perforation, and blindness. therefore, a reasonable and effective treatment plan should be chosen according to the degree of tao. the aim of this clinical study is to: 1. found the new diagnostic markers or imaging sequences. 2. establish and validate a multimodal and multiparameter prediction model for moderate to severe tao.


Eligibility criteria:
inclusion criteria: * according to the bartley criteria，diagnosed tao at our hospital after 2024/8/31 * moderate to severe patients defined by eugogo * cas ≥3 (on the 7-item scale) for the study eye exclusion criteria: * anticipated need for intervention due to sight-threatening complications or other significant and acute deterioration in vision * history of systemic (eg, oral or iv) steroid use with a cumulative dose equivalent to \&gt;1 g of methylprednisolone for the treatment of tao. * any major illness/condition or evidence of an unstable clinical condition that, in the investigator\&#39;s judgment, will substantially increase the risk to the participant, or confound the interpretation of safety assessments, if they were to participate in the study * any other condition that, in the opinion of the investigator, would impair the ability of the participant to comply with the study procedures or impair the ability to interpret data from the participant\&#39;s participation in the study * pregnant or lactating * any other condition that,would impair the ability of the participant to undergo orbital mri * incomplete information
outcome of symptoms in patients undergoing a heller myotomy

Conditions: Achalasia

Summary: the objective of this study is to review studies and patient symptoms before and after laparoscopic heller myotomy to assess outcomes following laparoscopic surgery for achalasia.

patients will answer questionnaires before and after surgery to evaluate their symptoms of achalasia and will also have their charts reviewed for relevant medical information.

Eligibility criteria:
inclusion criteria: * patients with achalasia who have had laparoscopic heller myotomies for the treatment of achalasia exclusion criteria: * no patients under the age of 18 will be included

Keywords: achalasia, heller myotomy
mnk therapy in releasing the superficial fascia for patients with aas: an assessor-blinded, randomised controlled trial

Conditions: Acute Ankle Sprain

Summary: the goal of this type of randomized controlled trial, employing a blinded evaluator methodology, to verify the clinical efficacy and safety of mnk therapy. this aims to provide a reference for clinical practitioners and aas patients in their decision-making process. participants will randomly allocated into two groups using a random number table method, with forty patients in each group. the experimental group (group 1) underwent mnk therapy to release the superficial fascia, while the control group (group 2) received conventional acupuncture treatment.


Eligibility criteria:
inclusion criteria: * 16 to 55 years old * clear history of trauma within 1 to 7 days * presence of localized swelling, pain, bruising, and limping symptoms in the ankle joint * pain in the ankle joint upon resistance * no accompanying fractures * diagnosis of acute ankle injury according to the "diagnostic and therapeutic criteria of traditional chinese medicine" * no prior treatment before participating in this therapy * willingness to participate in this study and signing of the informed consent form exclusion criteria: * individuals with clear indications for surgery * those suffering from gout, rheumatoid arthritis, joint tuberculosis, joint tumors, etc. * pregnant or breastfeeding women * individuals with serious primary diseases of the cardiovascular, liver, kidney, brain, and hematopoietic systems * those with local skin lesions or skin diseases * individuals with coagulation dysfunction * those with severe fear of needles * individuals unwilling to comply with the treatment regimen

Keywords: acute ankle sprain micro-needle-knife superficial fascia randomized controlled trial
prospective study of patients with rheumatoid arthritis after the age of 65

Conditions: Rheumatoid Arthritis

Summary: rheumatoid arthritis (ra) is associated with a higher prevalence of infections, malignancies, osteoporotic fractures and cardiovascular diseases. few data are available regarding the prevalence and severity of these comorbidities in elderly ra patients. the purpose of this study is to determine the effect of age on prevalence and severity of comorbidities in ra.

prevalence of rheumatoid arthritis (ra) in elderly is increasing because of the increasing life expectancy. ra is associated with a higher prevalence of infections, malignancies, osteoporotic fractures and cardiovascular diseases. the purpose of this study is to determine the effect of age on prevalence and severity of comorbidities in ra. this study also aims to determine whether age influences disease progression and efficacy and tolerance of treatments. this study will compare two groups of patients : patients older than 65 years old and patients younger than 50 years old, matched for gender and disease duration. the first part of the study will be cross-sectional and will aim to compare characteristics regarding ra manifestations and comorbidities of the two groups at inclusion. whereas the second part will be prospective to assess the occurrence of comorbidities and the efficacy and safety of treatments in these two groups. patients will be assessed every year during 5 years in accordance with usual follow-up of the patients. this study could help to better manage elderly ra patients and to modify clinical practice.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of rheumatoid arthritis according to american college of rheumatology (acr) /eular 2010 criteria or american college of rheumatalogy 1987 criteria * age \>65 years or patients between 18 and 50 years matched for sex and disease duration with the group of elderly patients (control group) exclusion criteria: * patients who do not understand rules and implications of the study

Keywords: rheumatoid arthritis elderly infections cardio-vascular disease osteoporosis cancer
rituximab bs intravenous infusion 100mg・500mg [pfizer] post-marketing database study

Conditions: Lymphoma

Summary: to evaluate the incidence of the outcomes for the safety specifications in patients of medical data vision database in japan diagnosed with cd20 positive b-cell non- hodgkin's lymphoma who were treated with rituximab pfizer to compare it with outcomes in patients who were treated with rituxan from 01 january 2020 through 31 december 2024


Eligibility criteria:
inclusion criteria: 1. have prescription of rituximab pfizer or rituxan within the enrollment period (index date: first prescription date within the enrollment period). 2. have diagnosis of cd20 positive b-cell non- hodgkin's lymphoma on the index month or within 6 months before index date 3. have at least 6 months of look back period and at least one medical record prior to 7 months before the index date. 4. have not prescription of rituximab product before index date(comparative analysis set only). exclusion criteria: 1. have any diagnosis of other indications of rituximab products other than cd20 positive b-cell non- hodgkin's lymphoma before index date .

Keywords: lymphoma rituximab infection
dysphagia after thyroidectomy

Conditions: Goiter; Thyroid Disease

Summary: the goal of this observational study is to develop a questionnaire for measuring swallowing and throat discomfort symptoms in patients with goiter or thyroidectomy, which complies with the model of rasch and which satisfies the fundamental measurement axioms (e.g., unidimensionality, linearity, generalizability). developing a scale with such characteristics would provide clinicians and researchers with a reliable tool for assessing the impact of goiter and for measuring the outcomes after surgery. also, the study will assess the psychological impact of goiter and thyroidectomy, as well as the characteristics of the surgical scar after thyroidectomy. the questionnaire will be developed in the first phase of the study. items and response categories will be identified through interviews performed with patients affected by goiter or after thyroidectomy. in the following phases of the study, the questionnaire will be administered to patients before and after thyroidectomy.


Eligibility criteria:
inclusion criteria: * diagnosis of goiter or thyroidectomy. exclusion criteria: * diagnosis of other neurological disorders or disorders involving the aerodigestive tract that could cause swallowing disorders. * previous surgery of the neck or involving the aerodigestive tract.

Keywords: nodular goiter thyroidectomy dysphagia psychometrics rasch analysis
efficacy and safety study of tesamorelin in chronic obstructive pulmonary disease (copd) subjects with muscle wasting

Conditions: Chronic Obstructive Pulmonary Disease (COPD)

Summary: a significant proportion of copd subjects experience muscle wasting, which has been associated with increased morbidity, impaired physical functioning, and a poor quality of life. muscle wasting is associated with reduced muscle strength in copd subjects. in particular, weakness of peripheral muscles has been reported to play an important role in the reduced functional capacity and impaired exercise performance. the primary objective of this study is to investigate the effect of tesamorelin, in conjunction with exercise training, on lean body mass measured by dual energy x-ray absorptiometry (dxa) scan.


Eligibility criteria:
inclusion criteria: * male or female subjects aged 40-75 years (y) inclusive * documented diagnosis of moderate to very severe copd (gold stage 2, 3, or 4) * stable copd (i.e., no exacerbation) for at least 6 weeks prior to screening * able to participate in a supervised exercise training program * evidence of muscle wasting exclusion criteria * participation in a pulmonary rehabilitation program or in any supervised exercise program during the 4 months prior to screening * more than 4 exacerbations in the year prior to screening * life-threatening exacerbation in the year prior to screening * requirement for long-term oxygen therapy (\> 12 hours of oxygen per day) * critical illness or co-morbid conditions that may interfere with study conduct or endpoint measurements * use of agents known to increase lean body mass within 3 months prior to screening * hypopituitarism, history of pituitary tumor/surgery, head irradiation, or severe head trauma

Keywords: copd muscle wasting
comparison of the effects of oral ulceration healing in patients wearing a removable denture

Conditions: Oral Mucosa; Ulcer

Summary: the aim of the study was comparing the effectiveness of oral mucosa healing properties of different preparations: chx=0,2% chorhexidine digluconate, chs=8,7% choline salicylate, con=control group, in patients with delivered removable dentures, during the adaptation period.

the efficacy of oral topical medications in aiding regeneration and healing of oral soft mucosa, caused by the use of removable prosthetic restorations was analyzed. these medications, with different functional properties, are recommended for patients who develop oral mucosa lesions during adaptation to new removable prostheses. the evaluation of the efficacy of these agents was based on a comparison of the area of oml before and after the treatment. the study was designed to evaluate healing after the application of a topical medication containing 0.2% chlorhexidine digluconate and 8,7% choline salicylate as an active ingredient. patients were asked to use topical medication 3 times a day, applying the size of a pea on the oral mucosa lesion. participants in groups chx and chs were instructed not to eat or drink for 1 hour following the application of medication because of its functional and antibacterial properties. patients were asked to wear new dentures between control visits, even when they felt discomfort while using them. patients in the control group were not using any topical medication. according to randomization patients suffering from oral mucosa lesion (oml) were divided into three groups. using a transparent millimeter grid superimposed on the oml, the wound surface area (wsa) was measured in mm\^2. a very precise measurement of the wsa was possible thanks to the use of a millimeter scale on the digital photo image. every, even partially filled square was included in the area of the oml. graphical analysis using photo for windows software consisted of adding all the squares within which the oml was observed. all the intraoral images of oml have been taken in reproducible conditions (ambient light, lens and camera settings, distance 5 cm). this measurements were carried out during all check-up visits on day 0, 1, 4, 7 and 14.

Eligibility criteria:
inclusion criteria: * oral mucosa lesion oml as a result of new denture adaptation * partial dentures ii and iii * prostheses delivered for the during the period of the study patient * patient consent exclusion criteria: * systemic conditions affecting the wound healing: diabetes * prosthetic stomatitis according to newton's classification * parafunctional habits, bruxism * autoimmune diseases

Keywords: prosthetic materials functional properties antibacterial properties chlorhexidine choline salicylate
earplugs and eye masks for reducing delirium

Conditions: Delirium; Hospital Acquired Condition

Summary: there has been some recent evidence to support the use of earplugs and eye masks to prevent delirium, but the existing studies have been small, have not been thoroughly replicated, and have only been conducted with intensive care unit (icu) patients. therefore, we propose to conduct a single-arm pilot study for an eventual single-blinded randomized controlled trial designed to assess the efficacy of earplugs and eye masks worn at night for prevention of delirium in a population of general medicine inpatients over the age of 65. the primary outcome will be incidence of delirium as measured by confusion assessment method (cam). in this pilot study, we will assess feasibility and will not perform any statistical comparisons. in the subsequent randomized controlled trial, we will be comparing the hazard rates on an intention-to-treat basis. secondary outcomes will be exploratory and include length of stay, cost data, and use of pharmacologic interventions for sleep, delirium, or agitation. there are no physical risks and no cost to the subjects in this study.


Eligibility criteria:
inclusion criteria: * admitted to general medicine (units 8100 and 8300 only) from the duke university hospital (duh) emergency department * age \>= 65 exclusion criteria: * admitted from outside hospitals, clinics (i.e., direct admissions), or transferred from another department * admitted as "observation" (i.e., expected length of stay \< 2 nights) * admitted \> 24 hours prior to time of enrollment * non-english-speaking patients will be excluded because a language barrier would introduce inaccuracy into the cam measurement and for feasibility reasons (e.g., availability of translator services) * blind or deaf patients will be excluded because they are unlikely to benefit from the intervention, but sensory-impaired patients will be included * patients lacking decision-making capacity for whom no legally authorized representative (lar) is available * primary reason for admission "altered mental status", drug withdrawal, stroke, or seizure * patients for whom a withdrawal pathway has been preemptively initiated based on their substance use history (e.g., the alcohol withdrawal pathway order set or other as needed ("prn") orders for the indication of withdrawal) * delirium present at time of enrollment * glasgow coma scale (gcs) \< 10 at time of enrollment * enrolled in this trial during a previous admission (i.e., we will not resample) * enrolled in a separate trial this admission * contraindication to using earplugs or an eye mask (e.g., facial trauma or other safety concern) * significant fall risk per nursing assessment
opti-free® puremoist® for presbyopic contact lens wearers

Conditions: Presbyopia

Summary: the purpose of this study is to evaluate opti-free® puremoist® (ofpm) compared to non-hydraglyde® multi-purpose contact lens solutions in presbyopes currently wearing soft contact lenses and experiencing symptoms of dryness.


Eligibility criteria:
inclusion criteria: * must sign an informed consent document; * current adapted two-week/monthly replacement soft contact lens wearers (at least 2 months) with symptoms of contact lens induced dryness; * near spectacle add of +0.50 or greater; * best corrected visual acuity (bcva) to 20/30 or better in each eye at distance; * willing to wear lenses for a minimum of 5 days per week, 6 hours per day, and attend all study visits; * currently using a non-alcon multi-purpose solution to care for lenses (at least 2 months); * use of digital devices (eg, smart phone, tablet, laptop computer, or desktop computer) for 20 consecutive minutes at least twice a week and willing to continue the same pattern for the duration of the study; * other protocol-specific inclusion criteria may apply. exclusion criteria: * extended wear contact lens wearer (sleeps in lenses 1 or more nights per week); * any anterior segment infection, inflammation, disease, or abnormality that contraindicates contact lens wear as determined by the investigator; * any use of systemic or ocular medications for which contact lens wear could be contraindicated, as determined by the investigator, including use of any topical ocular medications that would require instillation during contact lens wear; * monocular (only 1 eye with functional vision) or fit with only 1 lens; * known sensitivity to any ingredients in ofpm; * prior refractive surgery; * history of herpetic keratitis, ocular surgery, or irregular cornea; * pathological dry eye that precludes contact lens wear; * use of mechanical eyelid therapy or eyelid scrubs within 14 days before visit 1 and not willing to discontinue during the study; * participation in any clinical study within 30 days of visit 1; * currently using or have not discontinued restasis®, xiidra® or a topical steroid within the past 7 days; * other protocol-specific exclusion criteria may apply.

Keywords: contact lens induced dryness
validation of emergency surgery score (ess) in egyptian patients undergoing emergency laparotomy

Conditions: Emergencies

Summary: to assess the accuracy of emergency surgery score in predicting postoperative morbidity and mortality in emergency laparotomy.

emergency laparotomy is the most common emergency surgery which considered a life saving exploratory procedure for which the clinical presentation, underlying pathology, anatomical site of surgery, and preoperative management vary considerably. there are more than 400 opcs codes describing surgery that could come under the umbrella term of 'emergency laparotomy' which reflect the diverse nature of this surgical cohort. in spite the lack of data on the outcomes of emergency laparotomies it is generally considered very poor mortality rates following emergency laparotomy internationally reported range from 13% to 18% at 30 days even after innumerable advances in surgical skills, antimicrobial agents and supportive care. there is a need for early prognostic evaluation of these individuals to identify patients in high risk for more agressive treatment using an ideal scoring system will help in ;.making appropriate decision on those patients. accurately predicting the risk of developing serious complications or die . categorizing patients into different risk groups which would help to prognosticate the outcome, select patients for intensive care and determine operative risk, thereby helping to choose the nature of the operative procedure . the emergency surgery score (ess) was developed as a novel preoperative risk assessment tool for patients undergoing egs in 2016 ess accurately predicts outcomes in all types of emergent laparotomy patients and may prove valuable as a bedside decision-making tool for patient and family counseling, as well as for adequate risk-adjustment in emergent laparotomy quality benchmarking efforts.10

Eligibility criteria:
inclusion criteria: * patients more who are 18 years old or older. * patients who are in need of an emergency laparotomy within 24 hours of admission. exclusion criteria: * patients less than 18 years old. * patients who are not accessible for follow up to the 30th postoperative day.
project aware 2.0 to improve awareness, willingness and ability for research and enrollment in clinical research

Conditions: Huntington Disease

Summary: the project aware 2.0 survey is intended to gain knowledge about the feelings, attitudes, and beliefs of hd family members, care partners and others affected by hd towards the way drug trials and observational studies are communicated and conducted.

the project aware 2.0 survey will be offered to hd families via hsg's online platform called myhdstory®. the survey will obtain input and knowledge about their feelings, attitudes, and beliefs concerning clinical research and the process by which hd studies are communicated and conducted. project aware 2.0 is intended to provide the hd research community with the insight and tools to help (a) improve prospective research participants' awareness, willingness, and ability to participate in clinical research for hd; and (b) design clinical studies and trials in the future.

Eligibility criteria:
inclusion criteria: * participants must either have hd or be at risk for having hd * participants must be 18 years of age or older * participants must live in the united states * inclusion of participants will not be based on race, gender, or ethnicity. exclusion criteria: -

Keywords: hsg, hd, observational
quality of life after esophagectomy for cancer - step 1

Conditions: Esophageal Cancer; Sleep Disturbance; Quality of Life

Summary: background: a recent systematic review showed that patients undergoing esophagectomy for cancer had scores of physical function, vitality and performance of health in general significantly lower than those obtained from the reference population. the analysis of the quality of life at six months follow-up showed that the total score and physical function were better before surgery and symptoms-based scales indicated that the fatigue, dyspnoea and diarrhea were worse six months after esophagectomy. the objective of this study is therefore to assess the impact of esophageal resections for cancer on the quality of life of patients and to improve it through simple interventions of post operative care. the study is divided into two steps. this is step 1. patients will be randomized into four groups receiving respectively: psychological counseling for support plus appropriate measures to reduce sleep-wake rhythm disorders during icu stay; psychological counseling alone; appropriate measures to reduce sleep-wake rhythm disorders during icu stay alone; or standard care. the primary end point are the items sl (sleep disorder) and ql2 of the qlq c30, and the secondary end point is the score of the psqi.


Eligibility criteria:
inclusion criteria: * age above 18 years old * scheduled for esophagectomy for cancer exclusion criteria: * age below 18 years old * incapability to autonomously fill in questionnaires * primary language not italian

Keywords: esophageal cancer sleep disturbance quality of life