Kornimate/medical-research-clean huggingface dataset:
evaluation of a computer-based system using cell phones for hiv people in peru

Conditions: HIV; Adherence; Sexual Behavior; HIV Infections

Summary: the investigators propose to develop and evaluate a computer-based intervention using cell phones to enhance adherence to antiretroviral treatment (art) and support of hiv transmission risk-reduction among adult hiv-positive patients in peru.

adherence to art is critical for treatment success at the individual level and to avoid the onset of resistant strains of hiv. in peru, where art has recently been introduced, adherence to hiv treatment has not yet been addressed properly. innovative approaches using information technologies such as cell phones are needed to increase adherence to art for people with hiv/aids. the specific aims of the study are to: 1) conduct formative research to assess culturally-specific behavioral messages to be included in the computer-based system; 2) develop and test an interactive computer-based system using cell phones to enhance adherence to art and to deliver hiv transmission risk reduction messages; 3) evaluate the impact of the system on antiretroviral adherence and sexual risk behaviors.

Eligibility criteria:
inclusion criteria: * hiv-positive healthy male or female aged greater than or equal to 18 * currently on art * patients with a mobile phone for their personal use (not shared) * patients who know how to retrieve read text messages on their mobile phone * signed and dated written informed consent prior to admission to the study exclusion criteria: * patients whose clinical condition might have interfered with the study (e.g., deafness, serious mental illness, mental retardation) * patients unable to give their informed consent.

Keywords: adherence appointment cell phone cellular phone clinic computers controlled clinical trials, randomized hiv/aids health informatics health behavior information technology internet intervention medication patient satisfaction patient self-report patients peru phone public health public health informatics randomized randomized controlled clinical trials randomized controlled trials research secondary prevention self-report sex behavior sexual behavior sexually transmitted diseases sexually transmitted infection survey instrument surveys telephone telephone, cellular text unprotected sex viral load result vulnerable populations www anti-retroviral therapy consumer informatics evidence base follow-up medication adherence medication compliance randomization randomized controlled study randomized trial randomly assigned safer sex treatment adherence user centered design web world wide web
safety, pharmacokinetics and pharmacodynamics study of bms-866949 in healthy subjects

Conditions: Depression

Summary: the purpose of this study is to evaluate the safety profile, tolerability, pharmacokinetics and pharmacodynamics of ascending single doses of bms-866949 in healthy subjects.


Eligibility criteria:
inclusion criteria: * healthy male 18-55 * women not of child bearing potential, 18-55 exclusion criteria: * history of or current treatment for psychiatric illnesses, substance abuse or dependence * history of a clinically significant neurological disorder (e.g., history of stroke, head trauma, etc.)
photobiomodulation with polarized light as adjunctive treatment in diabetic foot ulcer

Conditions: Wound Healing Disorder

Summary: effect of photobiomodulation with polarized light on wound healing and aerobic microflora in diabetic foot ulcer

effect of photobiomodulation with polarized light on wound healing and aerobic microflora in diabetic foot ulcer both sexes were included and intervention will be given for two months, wound healing will be assessed by measuring the surface area and the aerobic microflora will be isolated and controlled on the basis of bio-gram and antibiogram at the beginning and at the end of treatment.

Eligibility criteria:
inclusion criteria: 1. the patients with diagnosed diabetic foot ulcer lasting at least 4 weeks ( sized from 0.5 to 2 cm 2. cooperative and mentally stable patients . exclusion criteria: 1. hepatic patients . 2. uncontrolled hypertension . 3. uncontrolled diabetic patients with hba1c\>8.5% . 4. neurological disorders . 5. musculoskeletal disorders that interfere with program . 6. previous history or any sign of dvt .

Keywords: diabetes foot ulcer polarized light ;wound healing
study of denufosol (ins37217) in subjects with rhegmatogenous retinal detachment

Conditions: Retinal Detachment

Summary: the purpose of this study is to test if denufosol will remove the fluid build-up in the eye so that the retina can be re-attached without invasive surgery.

the purpose of this trial is to determine if administration of denufosol is well-tolerated and more efficacious than placebo in stimulating subretinal fluid reabsorption and retinal reattachment without surgical intervention in subjects presenting with rhegmatogenous retinal detachment.

Eligibility criteria:
inclusion criteria: * have rhegmatogenous retinal detachment in only one eye * be able to receive intravitreal injection of study drug and be able to wait 24(+/- 6) hours to have detachment surgically treated or retinal breaks repaired per judgement of investigator * no more than 3 separate identifiable retinal breaks that are clustered together and confined within an area no more than 2 clock hours in extent * retinal detachment must be large enough such that it cannot be immediately repaired with laser photocoagulation or cryotherapy * have pinhole acuity (using etdrs) of macula-on, 20/50 or better in both eyes or macula-off, 20/50 or better in non-study eye and have history, prior to detachment, of reading capability in study eye exclusion criteria: * have a non-rhegmatogenous retinal detachment * have large retinal break(s) whose total break area is greater than 1 clock hour in extent * have evidence of atrophic retinal pigment epithelium, choroid, choroidal detachment or intraocular inflammation * be monocular * have a prior retinal detachment repair or a congenital condition that places a greater risk for rhegmatogenous retinal detachment * have proliferative vitreoretinopathy greater than grade b * have pre-existing subretinal or vitreous hemorrhage, corneal opacity, or other conditions which limit the view of peripheral retina * have any co-existing macular pathology or other retinal conditions that can limit visual acuity * currently have uncontrollable elevated intraocular pressure, advanced glaucoma, or any history or current evidence of endophthalmitis in the affected eye * have symptoms consistent with a rhegmatogenous retinal detachment such as visual disturbance greater than 14 days prior to screening if macula-on or history of loss of reading vision in affected eye for greater than 6 days prior to screening if macula-off * have a retinal detachment with evidence of demarcation lines or evidence of subretinal fibrosis visible upon fundus examination * be currently taking medications that could obscure or confound study results including acetazolamide (diamox) and dorzolamide * have had a periocular, retrobulbar or intravitreal injection in the affected eye, including corticosteroids in the 3 months prior to screening or require one

Keywords: rhegmatogenous retinal detachment detached retina retinal tear retinal break
extracorporeal membrane oxygenation physical training

Conditions: Critically Ill, Mechanically Ventilated; Extracorporeal Membrane Oxygenation Complication

Summary: critically ill patients who require extracorporeal membrane oxygenation (ecmo) are the sickest in the hospital. more patients are surviving but survivors have compromised functional recovery for months or years. this trial aims to determine if early, physical training commenced within 48 hours of ecmo is feasible and improves muscle strength and functional status in patients compared to standard practice in a randomised controlled trial of 30 icu patients.

the use of extracorporeal membrane oxygenation (ecmo) has expanded dramatically in australia and globally. while life-saving in the short-term, it is typically associated with prolonged immobility and inflammation, which contributes to severe muscle weakness and wasting. standard care delivers minimal physical training while patients remain on ecmo because standard care prioritises concerns about catheter dislodgement and cardio-respiratory strain. however, in other intensive care unit (icu) conditions, techniques have been developed to allow early physical training in patients previously thought too unstable to be exercised, with important patient-centred and long-term cost-saving benefits. our preliminary work shows that early individualised physical training is safe in icu patients. a multicentre pilot study to establish feasibility in ecmo patients is urgently needed. the primary aim is to test the hypothesis that early, individualised, physical training (commenced within first 48 hours of ecmo) is feasible and improves functional recovery (the highest level of activity and duration). this has previously been reported to be associated with improved independent function at hospital discharge and discharge to home.1 the secondary aims are to test the hypothesis that early individualised physical training is (i) safe; (ii) improves muscle strength at day 7 and 10 and 20; and (iii) improves functional status (ims) at day 7, 10 and 20 in ecmo patients relative to standard care. we are also aiming to describe the acute physiological effects of early physical training (commenced within 48hours of ecmo initiation) respiratory and haemodynamic parameters, along with ecmo settings, will be recorded 30 minutes prior to each physical training session, during the session and 30 minutes post the training session. in addition, the range of values (min to max) for these parameters will be recorded for each 24hour period over the 7 days.

Eligibility criteria:
inclusion criteria: * adults ≥ 18 years of age * were physically independent prior to the current admission; * receiving ecmo (veno-arterial or veno-venous) for at least 24 hours; * clinician in charge of patient care has no objection to randomisation exclusion criteria: * have been in icu \> 5 days prior to the commencement of ecmo; * have received ecmo for more than 48 hours; * in the opinion of the treating clinician, is not expected to recover in 90 days (e.g. intracerebral haemorrhage); * whom death is expected within 24 hours; * are unable to communicate in english
long non coding rna in complications of systemic lupus

Conditions: Complication in Systemic Lupus Erythematosus

Summary: the precise role of rna in setting of this complication in systemic lupus erythematosus (sle) is largely unknown


Eligibility criteria:
inclusion criteria: * with systemic lupus exclusion criteria: vasculitis
study of buprenorphine-naloxone sublingual spray and suboxone® sublingual film in healthy volunteers

Conditions: Opiate Dependence

Summary: the primary objective of this study is to compare the bioavailability of a test formulation of buprenorphine naloxone sublingual (sl) spray to that of a single dose of suboxone® (buprenorphine and naloxone) sublingual film, under fasted conditions.


Eligibility criteria:
inclusion criteria: * meets protocol-specified criteria for qualification and contraception * is willing and able to remain confined in the study unit for the entire duration of each treatment period and comply with restrictions related food, drink and medications * voluntarily consents to participate and provides written informed consent prior to any protocol-specific procedures exclusion criteria: * has history or current use of over-the-counter medications, dietary supplements, or drugs (including nicotine and alcohol) outside protocol-specified parameters * has signs, symptoms or history of any condition that, per protocol or in the opinion of the investigator, might compromise: 1. the safety or well-being of the participant or study staff; 2. the safety or well-being of the participant's offspring (such as through pregnancy or breast-feeding); 3. the analysis of results
biomaterial to counteract ridge reduction following the removal of multiple adjacent teeth.

Conditions: Alveolar Ridge Trauma; Bone Resorption

Summary: an open, prospective, randomized, multicenter study focused on the ridge diminution in case of grafting of fresh extraction sockets with bio-oss collagen, bio-gide (geistlich pharma, wolhusen, switzerland), placing dentsply implants (astra tech system).

the removal of at least 2 adjacent teeth would cause more advanced hard tissue loss during healing than that occurring after removal of a single tooth with adjacent teeth present. in order to maintain the dimension of the ridge following tooth removal, bone grafts and bone substitutes have also been placed in the extraction socket. so far no data have been reported on the effect of removal of multiple adjacent teeth on bone loss at various aspects of the edentulous sites. furthermore, the potential effect on ridge contraction of implant placement in multiple fresh extraction sites is not documented. therefore, the objective of the study is to evaluate the possibility of counteracting un favourable ridge modeling after multiple tooth extractions by placing mineral bovine bone in the extraction sockets and covering the wound with a native collagen membrane. in addition, the possibility of placing implants in the grafted sites is evaluated after six month of healing. for these purpose 40 subjects with 2 or more fresh adjacent extraction sites in need of two or more implants replacing teeth will be enrolled. ridge dimensional changes will be measured after 6 months of healing; marginal bone loss will be measured after 3-years follow-up from the baseline (prosthetic delivery).

Eligibility criteria:
inclusion criteria:intact extraction sockets following removal of the natural teeth defined by: * a marginal dehiscence defect of any of the facial bone walls of 3 mm * no facial fenestration present in the apical of the marginal bone crest exclusion criteria: * untreated rampant caries and uncontrolled periodontal disease * uncontrolled diabetes or any other systemic or local disease or condition that would compromise post-operative healing * unable or unwilling to return for follow-up or unlikely to be able to comply with study procedures according to investigators judgement.

Keywords: bone grafting implantology oral surgery
a clinical trial comparing torcetrapib/atorvastatin to ezetimibe/simvastatin in subjects with a cholesterol disorder.

Conditions: Hyperlipidemia; Dyslipidemia

Summary: the torcetrapib project was terminated on december 2, 2006 due to safety findings. cholesterol levels will be measured over six weeks in subjects being treated with two different kinds of combination cholesterol medications to see how the different treatments compare to one another.

for additional information please call: 1-800-718-1021

Eligibility criteria:
inclusion criteria: * specific ldl-c levels based on chd risk after a six-week washout period. exclusion criteria: * women who are pregnant or lactating, or planning to become pregnant. * subjects taking any drugs known to be associated with an increased risk of myositis in combination with hmg-coa reductase inhibitors. * subjects requiring systemic steroids * subjects with any other medical condition or laboratory abnormality which could affect subject safety, preclude evaluation of response, or render unlikely that the subject would complete the study.
supine vs prone position during delayed cord clamping

Conditions: Newborn; Anemia; Umbilical Cord Problem

Summary: this study is conducted to evaluate if the prone position of the newborn on the chest of his mother at birth before delayed cord clamping leads to better hematocrit and hemoglobin at 24-48 hours of life compared to supine position.

at 30 hours of life, laboratory personnel drew a capillary sample from the infant's heel for hemoglobin, hematocrit, and total serum bilirubin at the same time as the newborn metabolic screening sample. there is no added heelstick to routine care, as current standard in our institution requires the bilirubin to be drawn at 30 hours of life. during universal screening for congenital cardiac defects (30 hours of life), a value of cerebral saturation (crso2) is measured using nirs with invos (in vivo optical spectroscopy, invos system, covidien, dublin, ireland, somanetics). sensors are placed over the forehead and the newborn is in supine position.

Eligibility criteria:
inclusion criteria: newborn ≥ 36 weeks gestational age and born vaginally and well appearing exclusion criteria: out born infant, infant born by caesarian section, preterm born less than 36 weeks ga, infant with intra uterine growth restriction (iugr: less than 10th percentile) asphyxiated infant infant needing immediate resuscitation, newborn with malformation (gastroschisis, omphalocele, anal atresia, severe head skin injury, congenital cardiac disease newborn with mother with preeclampsia or gestational hypertension or diabetes on insuline or hemolytic disease or on chemotherapy or on cortisone.

Keywords: delayed cord clamping
vaccination in the peripheral stem cell transplant setting for acute myelogenous leukemia

Conditions: Acute Myelogenous Leukemia

Summary: the purpose of this study is to evaluate clinical and laboratory safety associated with the administration of gvax leukemia vaccine and to determine the feasibility of generation of gvax leukemia vaccine in subjects with acute myelogenous leukemia (aml).


Eligibility criteria:
inclusion criteria: * initial diagnosis of de novo aml with no preexisting hematologic dysplasia for more than 3 months. * no prior therapy except leukapheresis or less than 72 hours of hydroxyurea. exclusion criteria: * prior myelodysplastic disorder, or treatment-related leukemia. * prior myeloproliferative disease. * acute promyelocytic leukemia (apl). * prior chemotherapy for a malignant or nonmalignant disorder.

Keywords: aml acute myelogenous leukemia gvax vaccine stem cell transplant autologous
safety study of airway clearance techniques in infants.

Conditions: Gastro-esophageal Reflux

Summary: the purpose of this study is to determine whether three airway clearance techniques ( bouncing, assisted autogenic drainage ( aad) and bouncing and aad) provoke or aggravate gastro-esophageal reflux in infants under the age of 1 year.


Eligibility criteria:
inclusion criteria: * infants \< 1 year * acid reflux monitoring exclusion criteria: * gestational age \<24 w * anti-reflux medication * nissen fundoplication * no parental consent

Keywords: gastro-esophageal reflux gor ger airway clearance techniques
clinical survey of minimally invasive ponto surgical technique (mips)

Conditions: Bone Conduction Deafness; Unilateral Deafness; Middle Ear Deafness; Mixed Hearing Loss

Summary: the objective of the study is to compare the outcomes after a surgical procedure with minimally invasive ponto surgery (mips, test group) and tissue preservation surgery (control) for placing oticon medical ponto implants and abutments.


Eligibility criteria:
inclusion criteria: * 18 years or older. * patient indicated for an ear level bone anchored sound processor. * healthy bone quality to allow for 4mm implant insertion. exclusion criteria: * intraoperative switch to an alternative surgical technique * patients undergoing re-implantation (on the side being included in the study) * previous participation in the c47 study. * inability to participate in follow-up. * psychiatric disease in the medical history. * mental disability. * presumed doubt, for any reason, that the patient will be able to show up on all follow-ups. * diseases or treatments known to compromise the bone quality at the implant site, e.g. radiotherapy, osteoporosis, diabetes mellitus. * patients with natural skin height of \>12mm (as there will be additional skin reduction needed)
active bathing to eliminate infection (abate infection) trial

Conditions: Healthcare Associated Infections; Methicillin Resistant Staphylococcus Aureus; Multi Drug Resistant Organisms

Summary: the abate infection project is a cluster randomized trial of hospitals to compare two quality improvement strategies to reduce multi-drug resistant organisms and healthcare-associated infections in non-critical care units. the two strategies to be evaluated are: * arm 1: routine care routine policy for showering/bathing * arm 2: decolonization use of chlorhexidine as routine soap for showering or bed bathing for all patients mupirocin x 5 days if mrsa+ by history, culture, or screen note that enrolled "subjects" represents 53 individual hca hospitals (representing \~190 non-critical care units) that have been randomized.


Eligibility criteria:
inclusion criteria: * all hca hospitals that reside in the united states * note: unit of randomization is the hospital, but the participants are hospital units exclusion criteria: * non-critical care units where chlorhexidine bathing or decolonization for mrsa+ non-critical care patients is routine * pediatric, peri-partum, rehabilitation, psychiatry, and bmt units * units with \>30% cardiac or hip/knee orthopedic surgeries * unit average length of stay \<2 days * patients \<12 years-old * patients with known allergy to mupirocin or chlorhexidine

Keywords: hai mrsa vre