Kornimate/medical-research-clean huggingface dataset:
adaptive versus non-adaptive radiotherapy and 2 bladder filling instructions for patients with intermediate or high risk localized prostate cancer (arp)

Conditions: Prostate Cancer

Summary: the study is being done to compare the side effects between two different radiation techniques, standard non-adaptive radiation therapy vs. daily adaptive radiation therapy and also comparing two different bladder filling instructions to find out if customized bladder instructions may lead to better treatment outcomes.


Eligibility criteria:
inclusion criteria: * age ≥ 18 * pathological diagnosis of a primary prostate adenocarcinoma * nccn intermediate or high risk localized prostate cancer and clinically n0 and m0 by conventional imaging * intermediate: one or more of ct2b-t2c, psa 10-20, or gleason group 2 or 3 * high: one or more of: ct3a, psa \> 20, or gleason group 4 or 5. * consented to rt with moderate hypofractionated rt to pelvic nodes (44 gy) and prostate (60gy) in 20 fractions using standard bc cancer regimen * able to complete bc cancer posi questionnaireswilling to attend adaptive treatment slot timing as required by treating centre. * willing and able to have regular per protocol follow up and blood work * feasible to start protocol treatment within 120 calendar days of participant enrolment * continent of urine (or able to maintain continence with penile clamp/cuff during rt as needed) and able to follow bladder filling instructions. * baseline ipss score \< 20 at time of enrolment. * ecog performance status : 0-2. * nodal risk ≥ 20% using the memorial sloan kettering nodal risk nomogram (https://www.mskcc.org/nomograms/prostate/pre_op). * negative for bone metastases on bone scan within 3 months of enrolment * no involved nodes on abdomen and pelvic ct or pelvic mri within 3 months of enrolment. exclusion criteria: * indwelling urinary catheter. * hip prosthesis * prior pelvic radiotherapy * unable to lie still on rt treatment couch for more than 30 minutes * clinical t3b or t4 tumours * prior transurethral resection of prostate or radical prostatectomy * presence of a pelvic kidney. * prior pelvic radiotherapy. * significant urinary incontinence: ie \> 1 soaked, or 2 non-soaked pads per day. * inflammatory bowel disease, systemic lupus erythematosis, scleroderma, or other connective tissue disorders other than rheumatoid arthritis. * metastatic disease identified on staging investigations. * any other serious intercurrent illness or medical condition judged by the local investigator to compromise the participant's safety, preclude safe administration of the planned protocol treatment, or prevent the participant from being managed according to the protocol guidelines * potentially fertile patient who are unwilling to employ highly effective contraception

Keywords: adaptive radiotherapy
nationwide utilization of danish government electronic letter system for confirming the effectiveness of behavioral nudges in increasing influenza vaccine uptake among older adults

Conditions: Influenza; Behavior and Behavior Mechanisms

Summary: in randomized clinical trials and observational studies, influenza vaccination has been shown to be effective in reducing influenza-related illness, hospitalizations, cardiovascular events, and mortality in select populations. however, the real-world effectiveness of influenza vaccination is limited by its uptake. conducted during the 2022/2023 influenza season, the first nudge-flu trial demonstrated the effectiveness of two electronic behavioral nudging letter strategies in increasing influenza vaccination rates among older adults in denmark - a letter highlighting potential cardiovascular benefits of vaccination and a standard informational letter sent at baseline and repeated at day 14. this present study will once again investigate whether digital behavioral nudges delivered via the official, mandatory danish electronic letter system can increase influenza vaccine uptake among older adults including whether the effectiveness of previously successful strategies can be confirmed during a subsequent influenza season.

the study is a prospective, randomized, open-label implementation trial. the study population will consist of persons aged \>=65 years at january 15, 2024 - this age group is eligible for free-of-charge influenza vaccination in the official danish vaccination program. subjects will be identified through danish nationwide health registries including the danish civil registration system. individuals will be randomized to 1 of 7 arms (1 usual care arm and 6 intervention arms) with each testing different nudging strategies employing various behavioural economic principles. the interventions will be delivered through the official, mandatory danish electronic letter system. all subject data will be retrieved from the danish nationwide registries with the exception of information on intervention allocation. endpoints will be retrieved at prespecified dates using prespecified search algorithms.

Eligibility criteria:
inclusion criteria: 1. age \>=65 years at january 15, 2024 (eligible for free-of-charge influenza vaccination in the danish public health system) 2. access to the official, mandatory danish electronic mailbox system exclusion criteria: 1. persons living in nursing homes (approximated as any person living at an address with \>=6 inhabitants aged 80 years and above) 2. known to have already scheduled influenza vaccination appointment

Keywords: influenza vaccination nudging behavioral science
endovenous rfa versus ligation and striping for varicose veins

Conditions: Varicose Veins of Lower Limb

Summary: varicose vein is a common chronic disease affecting patient's quality of life. high ligation and stripping of the long saphenous vein is the traditional operation for varicose vein. the radiofrequency ablation (rfa) device used for treatment of varicose vein has been available in china since 2014. there are few studies comparing rfa and stripping in the treatment of varicose vein. this study was to investigate the outcomes of rfa and stripping for varicose vein. patients with varicose veins will be prospectively allocated to rfa group and stripping group. ultrasound follow-up will be performed to assess recanalization of long saphenous vein at 1 month, 3, 6 and 12 months. recurrence of varicose vein and improvement of symptoms will also be evaluated. the primary endpoints are technical success, complications and recurrence of varicose vein. secondary endpoints are duration of operation, blood loss, recovery time, venous clinical severity score, and medical cost. the treatment outcomes will be compared between the rfa group and stripping group. rfa is comparable to traditional stripping in the treatment of varicose vein, however, it is associated quick recovery, lower incidence of complications and higher medical cost.


Eligibility criteria:
inclusion criteria: * diagnosis of long saphenous varicose veins exclusion criteria: * contraindicated to operation due to severe comorbidities

Keywords: radiofrequency ablation high ligation and striping
otx-14-007: a phase 3 study evaluating the safety and efficacy of otx-dp for the treatment of chronic allergic conjunctivitis

Conditions: Chronic Allergic Conjunctivitis

Summary: the objective of the study was to evaluate the efficacy and safety of otx-dp (dexamethasone insert) 0.4 mg for intracanalicular use when placed in the canaliculus of the eyelid for the treatment of the signs and symptoms of chronic allergic conjunctivitis


Eligibility criteria:
inclusion criteria: * has a positive history of ocular allergies and a positive skin test reaction to a perennial allergen and a seasonal allergen * has a positive bilateral cac reaction to a perennial allergen within minutes of instillation exclusion criteria: * history of refractive surgery (including lasik procedures) * history of retinal detachment, diabetic retinopathy, or active retinal disease * presence of an active ocular infection or positive history of an ocular herpetic infection at any visit * use any of the disallowed medications during the period indicated * history of iop increase as a result of steroid treatment
biomarkers in blood samples from patients with hiv infection and stage iii or stage iv hodgkin lymphoma undergoing chemotherapy

Conditions: Lymphoma; Nonneoplastic Condition

Summary: rationale: studying samples of blood in the laboratory from patients undergoing treatment with hiv infection and hodgkin lymphoma may help doctors learn more about the effects of therapy on hiv. purpose: this research study is studying biomarkers in blood samples from patients with hiv infection and stage iii or stage iv hodgkin lymphoma undergoing chemotherapy.

objectives: primary * to quantify hiv-1 persistence in prospectively collected samples from patients on suppressive antiretroviral therapy undergoing chemotherapy for hodgkin lymphoma. outline: this is a multicenter study. blood samples are collected before, during, and after treatment for lymphoma for hiv-1 rna levels using standard and single copy assays and hiv-1 dna quantification (peripheral blood mononuclear cells). after completion of treatment, patients are followed up periodically for up to 2 years.

Eligibility criteria:
disease characteristics: * hiv-1 infection, as documented by a rapid hiv test or any fda-approved hiv-1 enzyme or chemiluminescence immunoassay (e/cia) test kit and confirmed by western blot at any time prior to study entry * documentation may be serologic (positive elisa and positive western blot), or other federally approved licensed hiv diagnostic test * prior documentation of hiv seropositivity is acceptable * diagnosis of untreated hodgkin lymphoma and participation in the parent protocol swog-s0816, "a phase ii trial of response adapted therapy of stage iii-iv hodgkin lymphoma using early interim fdg-pet imaging." patient characteristics: * no psychosocial conditions that would prevent study compliance and follow-up, as determined by the principal investigator * willing to provide serial blood samples prior concurrent therapy: * see disease characteristics

Keywords: stage iii adult hodgkin lymphoma stage iv adult hodgkin lymphoma hiv infection
tear osmolarity over time with artificial tears

Conditions: Dry Eye

Summary: the effect of artificial tears on tear osmolarity

tear osmolarity measures the amount of solutes in the human tear film. the higher the reading, the more likely the patient has dry eyes. some say it has "potential to be the gold standard" of dry eye testing. the investigators study the tear osmolarity at different time points after instillation of artificial tears.

Eligibility criteria:
inclusion criteria: between the ages of 18 and over inclusive. males or females any race or ethnic background patient is in generally good \& stable overall health. patient likely to comply with study guidelines \& study visits. informed consent signed. subjective evaluation of symptom of dryness (sesod): score 2 (mild) - exclusion criteria: corneal refractive surgery within 6 months of this study. intra-ocular surgery within 6 months or ocular laser surgery within 6 months. pregnant or lactating women. ocular pathology (includes glaucoma and cataract), which could impact results and/or place patient at risk. corneal staining grade 3 or higher no restasis for past 3 months discontinue topical medications for at least 1 week

Keywords: dry eye
paliperidone palmitate effectiveness assessment registry - longitudinal (pearl)

Conditions: Schizophrenia

Summary: the primary objective of this study is to determine if australian patients with schizophrenia treated with paliperidone palmitate under conditions of continuous monitoring of outcomes over a 12-month period achieve relapse rates comparable to published literature.

this study involves the establishment of pearl, an australian quality use of medicine clinical registry designed to collect clinical and social data on up to 300 patients with schizophrenia for a 12-month period after initiating treatment with intramuscular (im) injections of paliperidone palmitate as part of their routine clinical care. continuous feedback of clinical outcomes will be via regular reports to all registry sites. enrollment in pearl should be considered only after the clinical decision to prescribe im paliperidone palmitate has already been made because the treating physician has determined that this treatment is the best option for the patient. observational study - no investigational drug administered

Eligibility criteria:
inclusion criteria: * must fulfill the diagnostic criteria for schizophrenia disorders as defined by diagnostic and statistical manual of mental disorders version iv (dsm-iv) * must meet the approved therapeutic goods administration (tga) indication for injectable paliperidone palmitate * must have provided written informed consent indicating that they understand the purpose of and procedures required for the registry and are willing to participate in the registry. exclusion criteria: * those with a known hypersensitivity to either paliperidone or risperidone, or to any excipients in the paliperidone palmitate formulation * employees of the clinician or study centre, with direct involvement in the proposed registry or other studies under the direction of that clinician or study centre, as well as family members of the employees or the clinician.

Keywords: schizophrenia paliperidone palmitate invega sustenna registries quality of healthcare
breath analysis for the detection of invasive fungal infections

Conditions: Leukemia; Leukemia, Myeloid; Leukemia, Lymphoblastic; Neutropenia; Chemotherapy-induced Neutropenia; Invasive Fungal Infections; Invasive Pulmonary Aspergillosis

Summary: patients with leukemia and concomitant neutropenia are at high risk of developing invasive fungal infections (ifi) that are associated with high morbidity and mortality. as these patients typically have severe thrombocytopenia, direct diagnostic sampling with invasive procedures is often not possible due to the high peri-interventional risk. therefore, the presumptive diagnosis of ifi is primarily based on compatible lung findings on computed tomography and serologic detection of fungal cell wall components, which, however, have limited sensitivity and specificity. with the present study, the investigators aim to determine a set of specific volatile biomarkers in leukemia patients with proven or probable ifi using secondary electrospray ionization high-resolution mass spectrometry (sesi-hrms).


Eligibility criteria:
inclusion criteria: * diagnosis of acute leukemia * planned chemotherapy with a duration of hospitalisation of 2 weeks or longer * neutropenia (\<500/µl) present at inclusion or planned chemotherapy with expected neutropenia (\<500/µl) for more than 7 days exclusion criteria: * unable to follow instructions for breath analysis * anatomic abnormalities precluding the use of a mouthpiece for breath analysis
aim1: adequate selection of patients for thyroid biopsy: evaluation of a shared decision making conversation aid

Conditions: Thyroid Nodules; Thyroid Cancer

Summary: there is an epidemic of thyroid cancer that is harmful to patients and the medical system. the study hypothesizes that the use of an electronic conversation aid during clinical visits can help patients and clinicians collaborate when deciding the next step in management for a thyroid nodule. the study aims to update a conversation aid prototype that was developed to support shared decision making in the diagnosis of thyroid cancer. this entry (aim 1) has an associated study (aim 2) registered under nct04463719


Eligibility criteria:
inclusion criteria: * adults \>18 years old presenting for evaluation of a thyroid nodule exclusion criteria: * patients with hyperthyroidism * patients with previous biopsy of the nodule of interest * pregnant patients * prisoners

Keywords: thyroid nodules shared decision making
laparoscopic ventral mesh rectopexy versus delorme's operation in management of complete rectal prolapse

Conditions: Complete Rectal Prolapse

Summary: a comparative randomized study between laparoscopic ventral mesh rectopexy and delorme's procedure in treatment of complete rectal prolapse to ass both efficacy and complications

a comparative randomized study between laparoscopic ventral mesh rectopexy and delorme's procedure in treatment of complete rectal prolapse to ass both efficacy and complications. follow up is scheduled for 18 months to evaluate recurrence, continence state and complications

Eligibility criteria:
inclusion criteria: * patients with complete rectal prolapse exclusion criteria: * patients who underwent previous surgery for complete rectal prolapse * patients unfit for surgery * patients with associated colorectal diseases or pathology
residual shunt after patent foramen ovale device closure in patients with cryptogenic stroke

Conditions: Patent Foramen Ovale; Closure; Foramen Ovale

Summary: among consecutive 47 cryptogenic stroke patients who underwent pfo closure, a serial follow-up bubble contrast tee at 3 and 9 months after the index procedure was completed in 38 patients (81%, 46±10 years, 19 men). to evaluate the efficacy of pfo closure, the incidence of any- and significant residual shunt (≥moderate) was assessed.

the current investigation analyzed the date from the gachon university gil medical center pfo registry. between march 2014 to february 2017, all consecutive 47 patients with ischemic stroke and pfo documented by bubble contrast with no other identifiable cause of the ischemic event, such as, carotid or intracranial artery stenosis, atrial fibrillation, and thrombus, or atheromatous plaque at the aortic arch (i.e. cs), were analyzed. pfo closure was determined according to the heart-brain team's discretion (the team consisted of an interventional cardiologist, an echocardiographer cardiologist, a neurologist, and a radiologist) based on clinical data, echocardiographic findings, and patients' preference. the gore® septal occluder (wl gore \& associates, inc., newark, de, usa) (n=19) and the amplatzer® pfo occluder (st. jude medical, inc. st.paul, mn, usa) (n=19) and were used. the occlutec® pfo occluder was used in one patient who were excluded from the analysis. the institutional review board of gachon university gil medical center approved this study and all patients provided written informed consent prior to enrollment.

Eligibility criteria:
inclusion criteria: patients with cryptogenic stroke and pfo documented by bubble contrast tee exclusion criteria: patients with other identifiable cause of the ischemic event such as, carotid or intracranial artery stenosis, atrial fibrillation, and thrombus, or atheromatous plaque at the aortic arch

Keywords: patent foramen ovale pfo closure residual shunt bubble contrast transesophageal echocardiography
avatar-based social physical activity

Conditions: Type 1 Diabetes

Summary: this study is testing program where teens with type 1 diabetes play meta quest 2 virtual reality exercise games and talk, act, and paint about physical activity in virtual meetings with their peers and young adult role models. the outcomes are feasibility and user satisfaction.


Eligibility criteria:
inclusion criteria: * age of 14-17 years * diagnosis of type 1 diabetes or other absolute insulin deficiency diabetes for ≥6 months * moderate-to-vigorous physical activity less than half of recommended levels (defined as ≤3 days per week achieving ≥60min daily mvpa) * english literacy * home broadband wireless internet (≥25 mbps downloads, ≥3 mbps uploads on google internet speed test). this is used in \~98% of us households. * willing to use continuous glucose monitor for the duration of participation in the trial. * willing to use a computer or smartphone with web camera. * under regular care by a healthcare provider (defined as attending at least one appointment in the past year, plus access to verified 24hr phone number to reach the provider's team for insulin dose adjustments if assistance is needed) exclusion criteria: * a condition or disability besides type 1 diabetes that would preclude participation in group moderate-to-vigorous physical activity (e.g., cerebral palsy, current pregnancy)

Keywords: exercise adolescent video games self-management social support
both short- and long-term outcome differences according to patient frailty

Conditions: Frailty

Summary: the evaluation for cancer treatment successful has been used by overall survival rate and/or postoperative complications, especially surgical area. now postoperative qol has been more importantly required. therefore this study was conduced to investigate the association between postoperative outcomes and patients frailty.


Eligibility criteria:
inclusion criteria: * surgical patients exclusion criteria: * a body weight loss of \>10% during the 6 months before surgery; the presence of distant metastases; or seriously impaired function of vital organs because of respiratory, renal, or heart disease
the effect of folic acid administration in the progression of microalbuminuria

Conditions: Diabetic Nephropathies; Hyperhomocysteinemia

Summary: the development of diabetic nephropathy has been linked to several genetic polymorphisms, including those related with homocysteine metabolism such as the methylenetetrahydrofolate reductase (mthfr)and the cystathionine-beta-synthase genes. such alterations are associated with hyperhomocysteinemia, which is a known independent risk factor for the development of endothelial dysfunction and cardiovascular disease. in the mexican population there is a high prevalence of the c677t mthfr mutation. the investigators performed this study to evaluate the prevalence of this polymorphism in type 2 diabetic patients with diabetic nephropathy compared with type 2 diabetic patients without nephropathy, besides evaluating the relationship of hyperhomocysteinemia with endothelial dysfunction and microalbuminuria before and after the administration of folic acid. we proposed that the endothelial dysfunction caused by the hyperhomocysteinemia could be reversed after the administration of folic acid.


Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus patients with 5 to 15 years of diagnosis * microalbuminuria (defined as a urinary albumin/creatinine ratio between 30 and 300 mg/g) * a1c less than 9% in the last year exclusion criteria: * acute diabetic complications * a1c greater than 9% in the last year * acute infectious process * hepatic disease * thyroid disease

Keywords: diabetic nephropathies hyperhomocysteinemia folic acid endothelial dysfunction