Kornimate/medical-research-clean huggingface dataset:
prp for the treatment of erectile dysfunction (ed)

Conditions: Erectile Dysfunction

Summary: researchers are trying to determine the safety and efficacy of platelet rich plasma (prp) in the treatment of erectile dysfunction (ed).


Eligibility criteria:
inclusion criteria: * the patient must have given his informed and signed written consent * the patient has ed for longer than 1 year but less than 5 years. * the subject has a stable partner for at least 3 months. * the patient is pde5i responsive, meaning he is able to achieve and maintain an erection under the effect of the maximal dosage of pde5i * iief-ef, ehs, sep 2+3, and gaq domain score of 17-20 mild to moderate vascular erectile dysfunction: psv \> 25 cm/sec exclusion criteria: the patient is participating in another study that may interfere with the results or conclusions of this study * history of radical prostatectomy or pelvic cancer surgery * prior history of pelvic malignancies * prior pelvic radiation therapy * neurological disease which effects erectile function (spinal cord injury, iatrogenic injury to the pelvic or cavernous nerves) * psychiatric disease which effects erectile function * the patient is taking blood thinners * history of diabetes mellitus * history of coronary artery disease * evidence based criteria: doppler clinical exam ( psv \< 25 cm/sec defined criteria for severe erectile dysfunction not likely to respond to approved medical therapies) * biochemical evidence of hypogonadism (total testosterone \< 300 ng/dl)
clinical evaluation of daptomycin bone penetration

Conditions: Bone and Joint Infections

Summary: bone and joint infections are commonly due to gram-positive bacteria. treatment of these infections is difficult because of the need of prolonged duration of antimicrobial agents in combination with surgical procedure. moreover, in recent years, a growing resistance pattern to various antimicrobial agents has been observed for gram-positive bacteria. consequently, there is an urgent need for new drugs with high bone penetration for the treatment of those infections. the investigators hypothesized that daptomycin allow to achieve high concentrations in bone compartments.


Eligibility criteria:
inclusion criteria: * patient under treatment with daptomycin for more than 3 days with dosage at 6 mg/kg * patient undergoing imperative surgery with bone withdrawal * signed, and dated informed consent as defined by the institutional review board * male and female patients older than 18 years of age * patients with social insurance * patient with information on previous mandatory medical examination exclusion criteria : * patient with no treatment by daptomycin or with a dosage \< 6mg/kg or with less than 3 doses of daptomycine * patient with no need for surgery * patient younger than 18 years of age * pregnant and nursing women * patient refusal for inclusion * patients with deprived liberty * inability to complete the informed consent process because of problems with mental capacity

Keywords: daptomycin bone disease,infectious osteomyelitis diabetic foot staphylococcus aureus
the effects of tai chi and pilates for individuals with prediabetes

Conditions: PreDiabetes

Summary: the purpose of this study; to investigate the effects of clinical pilates and tai chi exercises on glycemic control, body composition, balance function and physical activity level in individuals with prediabetes.

the purpose of this study; to investigate the effects of clinical pilates and tai chi exercises on glycemic control, body composition, balance function and physical activity level in individuals with prediabetes. method: 54 individuals diagnosed with prediabetes in the endocrinology and metabolic diseases polyclinic at niğde ömer halisdemir training and research hospital will participate in our study. individuals will be divided into 3 groups: clinical pilates group, tai chi group and control group. before exercise, routine blood tests of individuals will be performed and their fasting and postprandial blood glucose and hba1c (glycosized hemoglobin) levels will be checked. bioelectrical impedance device will be used to evaluate body composition. timed up and go test and berg balance scale will be used to evaluate individuals' balance functions. physical activity level of individuals will be measured using the international physical activity level scale (ipaq) and the accelerometer device. evaluations will be repeated in all groups at the end of the 12-week exercise application. spss (statistical package program for social science) software will be used to analyze the data. statistical analysis of the study will be done with wilcoxon related two-sample test for intra-group measurements, and man whitney u test for inter-group evaluations. for the significance level, p value will be accepted as p\<0.05.

Eligibility criteria:
inclusion criteria: * patients who underwent biochemistry analysis for their glycemic control as part of routine checks at the endocrinology and metabolic diseases polyclinic. * patients who do not use any medication related to prediabetes * being able to walk independently * volunteering to exercise at least 3 days a week within the scope of the research exclusion criteria: * those diagnosed with type 1 diabetes, latent autoimmune diabetes in adults (lada) * going into a diabetic ketoacidosis coma, * having an orthopedic problem that prevents walking and exercising * having an orthopedic or vascular problem with the foot * having any neurological disease * cardiac, pulmonary or systemic disease that would prevent exercise have * losing more than 4 kg of weight per month

Keywords: prediabetes tai chi pilates exercise
modulating neuropathic pain with transcranial direct current stimulation

Conditions: Pain, Neuropathic; Complex Regional Pain Syndromes; Phantom Limb Pain; Spinal Cord Injuries

Summary: this study will examine whether a form of non-invasive brain stimulation can help reduce pain in people with persistent neuropathic pain.

this study will look at the effects of a painless, non-invasive form of brain stimulation, called transcranial direct current stimulation, or tdcs. tdcs is thought to increase the brain's ability to change. participants will be assigned to one of three groups by chance. two groups will receive tdcs at a level expected to increase the brain's ability to change, while the other group will receive tdcs at a level not thought to affect the brain's ability to change.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * have chronic (\>12 months) neuropathic pain, including but not limited to complex regional pain syndrome, phantom limb pain, or pain of neurogenic origin following spinal cord injury exclusion criteria: * history of seizures or epilepsy * addition or change in the dosage of drugs now to interfere with pain within 1 month of enrollment * untreated depression * history of head injury with loss of consciousness, severe alcohol or drug abuse, or psychiatric illness * positive pregnancy test or being of childbearing age and not using appropriate contraception * presence of ferromagnetic material in the cranium except in the mouth, including metal fragments from occupational exposure, and surgical clips in or near the brain

Keywords: neuroplasticity rehabilitation transcranial direct current stimulation
reading problems associated with central nervous system (cns) pathologies.

Conditions: Injury Brain; Eye Abnormalities; Multiple Sclerosis; Parkinson Disease; Ataxia, Cerebellar

Summary: this project aims to analyse eye movements, their alterations and influence in reading performance in patients with acquired cns diseases and compare them with people of the same age, without neurological or ocular pathology and with normal reading speed and pattern. the exploration is focused on the oculomotor system in patients with cns diseases, even without involvement of the primary visual pathway, and reveals more involvement than the one obtained by a simple ophthalmological examination.

the following protocol will be applied: neuropsychological function clock test- clock drawing, whose score corresponds to a scale of 1 to 6, from perfect organization to severe disorder respectively, with a cognitive deficit being a result greater than 3. this test is used to detect signs of heminegligence in addition to the line bisection test. it will consider the displacement of the central mark to the right side as a positive sign. mini-cognitive exam, whose cut-off score corresponds to 23 out of the 30 total, equal to or less than this figure, would indicate the presence of a cognitive deficit. far and near best corrected visual acuity primary gaze position cover test (far and near) extrinsic ocular motility nystagmus presence intrinsic ocular motility biomicroscopy of the anterior pole computerized visual field 30-2 intraocular pressure ocular fundus examination records with tobii pro nano hardware package eye-tracking system and tobii pro lab - full edition software. reading performance assessment: international reading speed texts (irest) attentional questionnaire based on the irest, two simple answer questions (one word) will be formulated for each text, at the end of the reading to check the reading comprehension of the patient evaluation of the speed and quality of horizontal and vertical reading: test dem (developmental eye movement). eye-tracking test: with an animation of a moving circle.

Eligibility criteria:
inclusion criteria: * patients and normal volunteers with ages between 18 and 80 years old. * clinical radiological neurological stability in acute cns diseases (≥ 3 months after acd). * best distant binocular visual acuity, equal or greater than 0.5 (decimal scale). best close binocular visual acuity, equal or greater than 20/40.glasses or soft contact lenses users. exclusion criteria: * presence of visual heminegligence evaluated with clock drawing test and line bisection test. * presence of visual agnosia: poppelreuter-ghent © test. * presence of cognitive deficit: mini mental state examination (mmse), with sufficient residual hearing capacity. * medical history, or presence after ophthalmic examination of: maculopathy, advanced cataracts, ophthalmological diseases affecting central visual acuity or macular fixation. * healthy control subjects should have normal monocular perimetry using standard swedish interactive threshold algorithm (sita) central 30-2 humphrey® perimeter test .

Keywords: eye tracking
accuracy of ultrasonography for the diagnosis of pneumoperitoneum in the emergency department

Conditions: Pneumoperitoneum

Summary: pneumoperitoneum could be due to life threatening conditions and its quickly diagnosis is important in the emergency department (ed). signs and symptoms are non-specific and radiography has low accuracy in the acute setting. computed tomography (ct) is considered the gold standard, however it is not a cost-effective option in the vast population of patients with abdominal pain. ultrasonography is able to detect as little as 2 ml of free air, however diagnostic accuracy of ultrasonography remains unclear. this study evaluates the accuracy of ultrasonography for the diagnosis of pneumoperitoneum, the most accurate abdominal scan and the most accurate echographic sign for the detection of free air. methods consecutive patients presenting to ed for acute abdominal pain and with a diagnosis of pneumoperitoneum at ct or at surgery (study group) and a similar number of patients without a diagnosis of pneumoperitoneum (control group) undergo abdominal ultrasonography in a standardized protocol that include 10 scans for each patient registered on a video of 5 seconds. the videos are randomly reviewed by 4 sonographers and by 2 physicians with no experience in ultrasonography blind to final diagnosis and to all clinical data with the aim of detecting for each scan pneumoperitoneum. accuracy of ultrasonography for the diagnosis of pneumoperitoneum will be calculated considering ct or surgery as gold standard. furthermore intra and interobserver agreement and the accuracy of each ultrasonographic sign and scan will be calculated.


Eligibility criteria:
inclusion criteria: * all patients more than 18 years with acute abdominal pain exclusion criteria: * refused consent * less than 18 years old * not possible to perform ultrasonography

Keywords: pneumoperitoneum free peritoneal air ultrasonography
evaluation the safety and efficacy of cilostazol in treatment of patients with fatty liver disease

Conditions: Fatty Liver, Nonalcoholic

Summary: the aim of the current study is to evaluate the safety and efficay of cilostazol in treatment of patients with fatty liver disease. several previous reports have shown that cilostazol ameliorates lipid imbalances in nafld. cilostazol appeared to exert beneficial effects against nafld


Eligibility criteria:
inclusion criteria: * adults between 18 and 60 years of age, both men and women, * clinical diagnosis of nafld, confirmed by imaging exams, * patients who present levels above the reference values of alt, ast and ferritin. exclusion criteria: * women in the menacing period, with the exception of those who have performed definitive sterilization, such as hysterectomy or tubal ligation. * patients with established prior diagnosis of chronic noncommunicable disease (congestive heart failure, decompensated or severe lung disease, neoplasms, renal disease, advanced liver disease - child pugh c classification) * patients with schistosomiasis; * hemochromatosis * wilson's disease * viral or autoimmune hepatitis * hiv virus carriers * woman who is breastfeeding * users of illicit drugs * patients with an intake of more than 20 g / day of alcohol and / or past alcoholism with abstention less than 6 months; * patients with ingestion of medications such as steroids, estrogens, amiodarone, warfarin, anti-convulsants, antipsychotics, tamoxifen or other chemotherapeutic agents in the last 6 months * patients with clinically manifest infections or inflammation, surgery, trauma or hospitalization in the last 30 days * chronic non-hepatic degenerative diseases (sclerosis, parkinson's disease or -alzheimer's disease) * patients who do not participate in all stages of the research.
effect of an artificial pancreas in patients undergoing pancreatic resection

Conditions: Pancreatic Diseases

Summary: this study evaluated that strict control of perioperative blood glucose following pancreatic resection by using an artificial pancreas would improve postoperative surgical site infection.

this study recruited 50 patients undergoing elective pancreatic resection for pancreatic diseases. perioperative blood glucose concentration was continuously monitored using an artificial pancreas system. we prospectively divided into two groups: one for whom glucose levels were controlled using a manual injection of insulin according to the commonly used sliding scale and another that received programmed infusion of insulin determined by the control algorithm of the artificial pancreas.

Eligibility criteria:
inclusion criteria: * patients undergoing elective pancreatic resection for pancreatic diseases. exclusion criteria: * weight loss greater than 10% during the previous 6 months * sign of distant metastasis * respiratory, renal, or heart disease

Keywords: surgery
trial of individualized adaptive rt in hpv-related high risk oropharynx cancer

Conditions: Oropharynx Cancer; HPV-Related Carcinoma

Summary: this study seeks to study the population of hpv-related oropharynx cancer patients that appear to be at highest risk for treatment failure with loco-regional failure and distant metastases including ct4 or cn3. the study team aims to determine if it is feasible to use multi-modality imaging (both dce mri and fdg-pet) to optimize the radiation boost in high risk p16+ opscc with similar or decreased toxicity compared to historic standard therapy.


Eligibility criteria:
inclusion criteria: * patients must have pathologically confirmed, locally/regionally advanced p16+ squamous cell carcinoma of the oropharynx referred for definitive chemo-rt * ajcc 8 stage iii (ct4 or n3) * ecog 0-1 performance status within two weeks of enrollment * pre-treatment laboratory criteria within four weeks of enrolment: wbc \> 3500/ul, granulocyte \> 1500/ul. platelet count \> 100,000/ul. total bilirubin \ 30cc/min * patients must be able to receive protocol chemotherapy in the judgment of the treating medical oncologist * age \>18 * all patients must be informed of the investigational nature of this study and given written informed consent in accordance with institutional and federal guidelines. * women of childbearing potential and male participants must agree to use a medically effective means of birth control throughout their participation in the treatment phase of the study. exclusion criteria: * pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception; this exclusion is necessary because the treatment involved in this study may be significantly teratogenic. * patients should have no contraindications to having a contrast enhanced mri scan. these contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the institutional standard practice. * patients should have no contraindications to having a contrast enhanced pet scan. these contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the institutional standard practice. * prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years (for example, carcinoma in situ of the breast, oral cavity, or cervix are all permissible). * any prior therapy for the study cancer; note that prior chemotherapy for a different cancer is allowable if \> 3 years prior to study;
a rct of centeringpregnancy on birth outcomes and maternal inflammation

Conditions: Preterm Birth

Summary: the purpose of the piinc study is to identify differences in placental inflammatory lesions between women participating in group prenatal care versus standard prenatal care, and additionally, examine whether the frequency of placental inflammatory lesions differ by race and income. the investigators hypothesize that women participating in group prenatal care will have lower pro-inflammatory profiles compared to women in routine prenatal care.

this is a supplementary investigation of placental inflammatory lesions among participants enrolled in a randomized controlled trial comparing biomedical, behavioral and psychosocial outcomes among pregnant women who participate in centeringpregnancy group prenatal care, to women in the traditional individual prenatal care and to investigate whether improving women's stress, activation and engagement will explain the potential benefits of centeringpregnancy on outcomes and health disparities. the study will be conducted in a large prenatal care center in south carolina. eligible white and black women will be recruited before 20 weeks of gestational age with low risk pregnancy.

Eligibility criteria:
inclusion criteria: 1. enrollment in nichd 1r01hd082311: centering and racial disparities: a randomized controlled trial on centeringpregnancy (the "cradle" trial). 2. pregnant women aged between 14-45 years 3. enrolled in prenatal care by 20 6/7 weeks' gestation exclusion criteria: 1. medical complications of pregnancy that would preclude prenatal care provision by nurse practitioners or participation in group care * pregestational diabetes, * severe chronic hypertension requiring medication, * morbid obesity with bmi \>49.99 * renal disease with baseline proteinuria \>1g/24 hours * any disease requiring chronic immunosuppression (sle, solid organ transplant) * active pulmonary tuberculosis * sickle cell anemia * human immunodeficiency virus infection * other medical conditions that would exclude women from group care at the discretion of the pi 2. pregnancy complications that would preclude prenatal care provision by nurse practitioners or participation in group care * multiple gestation * lethal fetal anomalies * other pregnancy complications that would exclude women from group care at the discretion of the pi 3. social and behavioral complications of pregnancy which would preclude prenatal care provision by nurse practitioners or participation in group care * current incarceration * severe psychiatric illness

Keywords: pregnancy
hepassocin levels in patients with polycystic ovary syndrome

Conditions: Hepassocin (Hepatocyte-derived Fibrinogen-related Protein 1); Polycystic Ovary Syndrome; Obesity; Insulin Resistance

Summary: the investigators aimed to investigate hepassocin levels in patients with polycystic ovary syndrome (pcos). there are 3 groups aged between 18 and 35 years as non-obese healthy women, non-obese women with pcos, and obese women (bmi\>30) with pcos.

hepassocin, also known as fibrinogen-like-protein or hepatocyte-derived fibrinogen-related protein 1, is a new marker for obesity and insulin resistance. in hepatic injury, it protects liver cells and promotes regeneration. high levels of hepassocin was shown to be independently associated with homa-ir and diabetes. since insulin resistance is known to be seen in patients with pcos, it may be expected that hepassocin levels may be higher in this group of patients.

Eligibility criteria:
inclusion criteria: * 60 patients with pcos aged between 18 and 35 and age-matched 30 healthy women with bmi\<30 exclusion criteria: premature ovarian failure (fsh \>30 miu/ml), tumors secreting androgens, non-classical congenital adrenal hyperplasia, cushing syndrome and irregular menses due to thyroid dysfunction (tsh \>5 miu/l ), hyperprolactinemia, more than twofold high transaminase levels (\>70 u/l), patients with cigarette smoking, alcohol consumption, oral contraceptives use, medications that are affecting liver function test, insulin metabolism and lipid metabolism, patients with a history of chronic diseases such as diabetes mellitus, hypertension, chronic liver disease, chronic kidney disease, autoimmune disease, inflammatory disease, malignant disease, bleeding disorders, and thrombosis were also excluded. all the patients were beta-hcg, hepatitis b surface antigen, and hepatitis c antibody negative. -
using qpop to predict treatment for sarcomas and melanomas

Conditions: Sarcoma; Melanoma

Summary: this is a multi-cohort proof of concept study involving patients with sarcomas or melanomas. patient models, both two- and three-dimensional, will be derived from tumour samples. these will then be used to evaluate drug sensitivities ex vivo. enrolled patients will undergo resections or biopsies as part of standard-of-care, which will be used to generate patient models. patients will receive standard-of-care systemic treatment. patient models will also be subjected up to a 14-drug screening panel. the majority of drugs in the respective drug panels has been shown to have activity in the respective cancers and would be used in the standard-of-care setting by treating physicians.

hypothesis: ex vivo drug testing on patient-derived models using qpop can identify drug sensitivities and combinations which may have clinical efficacy against sarcomas and melanomas. specific aim 1: to derive patient models, both two- and three-dimensional, of sarcomas and melanomas specific aim 2: to perform ex vivo drug testing on patient models of sarcoma and melanoma using qpop specific aim 3: to assess the efficacy of phenotype directed therapy using qpop to assign treatment after progression on standard-of-care treatment in sarcoma and melanoma

Eligibility criteria:
inclusion criteria: * diagnosis of sarcoma or melanoma * at least 1 tumour lesion amenable to fresh biopsy or resection * signed informed consent from patient or legal representative * able to comply with study-related procedures exclusion criteria: * there are no specific exclusion criteria if patients meet the inclusion criteria

Keywords: tumour-derived models organoids ex vivo drug testing personalised therapy qpop