Kornimate/medical-research-clean huggingface dataset:
comparison of efficacy of basket and balloon in the removal of pancreatic duct stones in chronic pancreatitis under ercp

Conditions: Pancreatitis, Chronic; Pancreatic Duct Stone

Summary: this study will compare the efficacy of basket and balloon in the removal of pancreatic duct stones under ercp.

chronic pancreatitis (cp) is an inflammatory disease that can causes progressive fibrosis of pancreatic tissue and eventually leads to damage of pancreatic exocrine and endocrine. according to statistics, the prevalence of cp in china is 13/10 million, which is still increasing. pancreatic duct stones are the most important pathological changes of cp. more than 50% of patients with cp are accompanied by pancreatic duct stones, which can lead to pancreatic duct obstruction, hypertension and tissue ischemia. removal of pancreatic duct stones under endoscopic retrograde cholangiopancreatography (ercp) are the first choice. ercp is effective in the treatment of pancreatic duct stones (diameter \< 5mm) located in the head/body of the pancreas by using basket and/or balloon catheter. in the clinical work of investigators' center, the ercp treatment of pancreatic duct stones also mainly adopts basket and balloon, but whether to try basket or balloon first is mainly determined by the subjective decision of the on-site endoscopist. more than 70% of patients use the above two tools in one ercp operation, which aims to achieve better effect, but the order of the two tools is uncertain. however, there is no relevant research on whether the first choice for the treatment of pancreatic duct stones is the basket or the balloon, or the combination of the two tools. this study will compare the efficacy of basket and balloon in the removal of pancreatic duct stones under ercp, including the difference of stone clearance rate, abdominal pain score (izbicki pain score), postoperative complications and medical expenses.

Eligibility criteria:
inclusion criteria: * symptomatic adult patients diagnosed with chronic pancreatitis and pancreatic duct stones; * stones (≤5 mm in diameter) are located in the main pancreatic duct of the pancreatic head/body with dilation of the proximal pancreatic duct. exclusion criteria: * suspected to have malignant tumors; * history of pancreatic surgery or gastrojejunostomy (billroth ii); * bile duct stricture secondary to cholangitis or chronic pancreatitis; * acute pancreatitis exacerbation or acute exacerbation of chronic pancreatitis (including biliary pancreatitis); * there is a stent in the main pancreatic duct; * coagulation dysfunction (inr≥1.5 or platelet count≤50×10\^9/l); * pregnant or breastfeeding women; * patients who refused to participate in the study.

Keywords: cholangiopancreatography, endoscopic retrograde
an exploration of the relationship between serum cytokine levels and the clinical efficacy of vedolizumab

Conditions: Ulcerative Colitis (UC)

Summary: it is uncertain the relationship between serum cytokine levels and the clinical efficacy of vedolizumab in the treatment of ulcerative colitis. the effects of cytokines on the efficacy of vidrecizumab in chinese uc patients were retrospectively analyzed. methods: patients with uc were recorded. these patients were detected the levels of cytokines.


Eligibility criteria:
inclusion criteria: * uc patients treated with vedolizumab exclusion criteria: * pregnant * had cognitive/developmental disorders that affected their ability to complete the study procedures * had medical illness or therapies potentially affecting bone, nutrition or growth status
comparative study of coadministered ceftaroline fosamil and nxl104 vs. intravenous doripenem in adult subjects with complicated urinary tract infections

Conditions: Urinary Tract Infections

Summary: this is a study in adult subjects with complicated urinary tract infection (cuti) comparing treatment with intravenous (iv) coadministered ceftaroline fosamil and nxl104 versus treatment with iv doripenem.


Eligibility criteria:
inclusion criteria: subjects must meet the following inclusion criteria: * have pyuria (white blood cells in the urine) * clinical signs and/or symptoms of cuti (including acute pyelonephritis) * have a pretreatment baseline urine culture specimen * the subject's infection would require initial treatment with iv antibiotics * the subject must require initial hospitalization to manage the cuti by the standard of care. exclusion criteria: subjects must not meet any of the following exclusion criteria: * history of any hypersensitivity or allergic reaction to any β-lactam (eg, cephalosporins, penicillins, carbapenems) * confirmed fungal urinary tract infection * intractable uti anticipated to require more than 10 days of study drug therapy * complete, permanent obstruction of the urinary tract\\ * permanent indwelling bladder catheter or instrumentation (including nephrostomy) or current urinary catheter that will not be removed during iv study drug administration * suspected or confirmed perinephric or intrarenal abscess * suspected or confirmed prostatitis * ileal loops or vesico-ureteral reflux * impairment of renal function including a calculated crcl of \< 30 ml/min, requirement for peritoneal dialysis, hemodialysis or hemofiltration, or oliguria * renal transplantation * life expectancy less than 3 months * evidence of significant hepatic, hematological, or immunologic disease or dysfunction * past or current history of epilepsy or seizure disorder * women who are pregnant or nursing

Keywords: complicated urinary tract infection acute pyelonephritis
the e-consult application for patients with breast cancer: interest in empathy and empowerment of patients.

Conditions: Breast Cancer; Surgery

Summary: demonstrate that the use of this application in consultation could improve the empathy perceived of the doctors by the patients after the consultation.


Eligibility criteria:
inclusion criteria: * patient \> 18 years old * patient referred for first consultation for surgery * patient referred for a breast tumorectomy and axillary sentinel node * no patient opposition to participating in this study exclusion criteria: * non-surgical management * management by any surgery other than breast tumorectomy and axillary sentinel node * any associated medical, social or psychopathological condition that could compromise the patient's ability to participate in the study * patient deprived of liberty or under guardianship * person subject to legal protection or unable to express their consent

Keywords: empathy
endotracheal intubation using videolaryngoscopy versus conventional direct laryngoscopy

Conditions: Intubation; Laryngoscopy

Summary: the investigators will evaluate the endotracheal intubation using video laryngoscopy versus conventional direct laryngoscopy on intubation success, quantified by the number of intubation attempts. the question is important because video laryngoscopes are more expensive than conventional direct laryngoscopes. the additional cost might be justified if video systems improve intubation success and reduce airway trauma. but if they do not, the extra cost would not be justified

the investigators propose to enroll participants scheduled for elective or emergent cardiac, thoracic, or vascular surgery in the designated operating room suite who require endotracheal intubation for general anesthesia. a cluster randomized multiple crossover design is used for this trial. the cardiac surgical suites will be divided into 2 sets of 11 operating rooms. each set is treated as a unit and randomized to receive video or direct laryngoscopy in 1-week blocks, always with 1 set randomized to each approach. for analysis, each operating room within a set will be considered a separate cluster. randomization will be conducted weekly on a 1:1 unstratified basis, using computer-generated codes maintained in a web-based system. investigators access these codes a day before each new treatment block begins.

Eligibility criteria:
inclusion criteria: * elective or emergent surgery requiring oral endotracheal intubation for general anesthesia. exclusion criteria: * the attending anesthesiologist prefers a specific approach for a particular patient * awake fiberoptic intubation is clinically indicated * insertion of double-lumen tube.

Keywords: airway videolaryngoscope direct laryngoscope
effects of memory boot camp on brain function in adults with symptoms of mild cognitive impairment (mci)

Conditions: Mild Cognitive Impairment

Summary: this is a prospective controlled clinical trial to determine the effects of a 12-week memory boot camp (mbc) program on cognitive function in older adults with symptoms of mild cognitive impairment.

this prospective trial evaluates the 12-week, multi-domain memory boot camp program for adults ages 55 to 85 with symptoms of mild cognitive impairment. the memory boot camp program incorporates neurofeedback, heart rate variability biofeedback, memory and cognitive training, and one-on-one coaching to encourage behavior change in diet, sleep, physical fitness, and stress reduction. participants are evaluated via neurocognitive assessments, questionnaires, quantitative electroencephalography parameters, and heart rate variability parameters at four time points: baseline, pre-program, post-program, and follow-up. the trial included a 12-week waiting period between baseline and pre-program, such that each participant acts as their own control, and follow-up takes place six months after completion of the program.

Eligibility criteria:
inclusion criteria: * subjective memory concerns * at least a high school education * having a current primary care doctor (or agreement to get a primary care doctor) * ability to read and write english * time availability of 4-5 hours/week * be in good general health exclusion criteria: * major depression * known neurological illness (e.g. alzheimer's or other dementia, parkinson's, epilepsy, multiple sclerosis) * serious psychiatric diagnosis * substance abuse * complete blindness or deafness * plans to be out of town for more than 10 days during the active phase of the trial * current or past client of the sponsor * complete blindness or deafness * employee or family member of sponsor employee
support pathway for ent cancer patients in a support care day hospital

Conditions: Otorhinolaryngologic Neoplasms

Summary: cancers of the upper respiratory / digestive tract are a major public health problem, ranking 5th among the most common cancers. surgery plays a central role in the recommended treatments for this type of pathology. the surgical procedure and its after-effects can be anxiety-provoking and have a major psychological, physical and social impact on patients over the long term. our institution's standard protocol is based on a pre-operative supportive care day hospital. the aim of this study is to compare our current care pathway with a more extensive interdisciplinary care pathway focused on patients' needs, in order to reduce anxiety and improve the quality of life of patients undergoing surgery for cancers of the upper respiratory / digestive tract. our aim is to use a prospective single-centre interventional study to assess the impact of adding three post-operative day hospitals to the existing care pathway in terms of reducing anxiety and improving the quality of life of patients undergoing surgery.


Eligibility criteria:
inclusion criteria: * patient undergoing surgery for vads cancer requiring at least one night's post-operative hospitalisation * understanding of spoken and written french * patient covered by a social security scheme exclusion criteria: * protected patient under a protective measure or legal safeguard * pregnant or breast-feeding patients * patients suffering from major cognitive disorders * patients with major anxiety disorders prior to the onset of cancer

Keywords: surgery quality of life anxiety supportive care
clinical trial of lamotrigine to reverse cognitive impairment in chronic corticosteroid-treated patients

Conditions: Memory Impairment Due to Corticosteroid Use; Hypomania Due to Corticosteroid Use; Hippocampal Atrophy Due to Corticosteroid

Summary: the purpose of this study is to determine if lamotrigine therapy is associated with improvement in mood, memory and hippocampal size and function in patients receiving chronic corticosteroid therapy. standard care for mood changes associated with corticosteroid therapy, if severe, includes antidepressants or other medications which can influence mood. no therapies, other than dose reduction or discontinuation, are currently available for memory loss associated with corticosteroid treatment. however, very little information is available on the treatment of either mood or memory changes associated with corticosteroid treatment, thus the proposed project may improve standard care.


Eligibility criteria:
inclusion criteria: * current corticosteroid use of 7 mg or more for 6+ months * 18-65 years of age exclusion criteria: * primarily non-english speaking * pregnant/nursing woman * currently taking depakote * currently taking rifampin * has diagnosis of major depressive disorder, schizophrenia, ptsd, bipolar i or bipolar ii (not related to corticosteroid use) * diseases with cns involvement * is to start a brief steroid taper * history of alcohol/drug abuse/dependence
optimizing fidelity to family-based treatment for adolescent anorexia nervosa

Conditions: Online Training for Therapists

Summary: this study will use a data base of archived therapy sessions of family therapy for adolescent anorexia nervosa to determine the role of fidelity to treatment and outcome. in addition, it will develop a novel, more efficient way to train therapists in family therapy for adolescent anorexia nervosa and examine if it is feasible to conduct a trial comparing this novel training to standard, more intensive training.


Eligibility criteria:
inclusion criteria: * masters or doctoral training in their field (psychology, psychiatry, family therapy). * must be licensed * have no reports of malpractice or loss of privileges at clinical institution * minimum caseload 5 adolescents with an each year over past 3 years * no previous training in fbt * computer/web access exclusion criteria: * previous fbt training for an

Keywords: fbt, fidelity, training
digitally assisted behavioral physical activity intervention in fibromyalgia

Conditions: Fibromyalgia; Physical Inactivity

Summary: digital health interventions have the potential to address physical inactivity as they are accessible to a large part of the population and can be delivered with high efficiency at a low cost. by enabling patient education, support for self-management, motivation, follow-up, feedback and communication, it can prevent, cure or treat many chronic conditions. these features can increase patient motivation and encourage compliance with home exercises and physical activity . digital behavior change interventions use digital technologies (such as websites, mobile apps, short message service or wearable devices) to promote and maintain health and have the potential to overcome many barriers compared to in-person programs by providing cost-effective, effective, and accessible information. no study has been found in turkey examining digital interventions or walking programs that include behavior change techniques to increase physical activity in patients with fibromyalgia syndrome. considering environmental, cultural and economic factors in this patient group in our society, the investigators think that walking, which the investigators think is the most appropriate physical activity method in terms of cost, accessibility and equipment, should be a permanent behavior. the use of technology to increase physical activity in the era of digitalization is important in terms of addressing the increasing inactivity during the covid19 pandemic period. the aim of this study is to estimate the effect of digital assisted physical activity intervention combined with patient education compared to patient education alone on physical activity level, functional capacity, quality of life, sleep quality, pain, fatigue, and perspective on exercise of adults with fibromyalgia syndrome.


Eligibility criteria:
inclusion criteria: * being between the ages of 18-65 * having a female gender * reporting at least 40 mm in weekly pain intensity from the vas scored between 0-100 with 'no pain' and 'worst possible pain' * using a fixed dose of medication for at least the past 6 months * being in the "inactive" group according to the international physical activity survey (not participating in physical activity to meet the physical activity recommendations of the guides) * using / agreeing to use whatsapp application exclusion criteria: * having another disease that affects the physical condition * cognitive inability to cooperate * being pregnant * inability to understand or speak turkish * concurrent autoimmune or inflammatory disease, * diseases affecting the central nervous system (eg multiple sclerosis, parkinson's disease), * serious psychiatric conditions that prevent participation (eg, psychotic disorders). * participation in a rehabilitation program in the past year, * exercising regularly for 6 months

Keywords: fibromyalgia physical activity digital health physical activity intervention
immediate unselected coronary angiography versus delayed triage in survivors of out-of-hospital cardiac arrest without st-segment elevation

Conditions: Out-of-hospital Cardiac Arrest

Summary: the aim of the trial is to compare immediate angiography in survivors of out of hospital cardiac arrest (ohca) without st-segment elevation versus delayed/selective catheterization with respect to 30 day mortality. the tomahawk trial is supported by the deutsches zentrum für herz-kreislauf-forschung (dzhk).

after inclusion and exclusion criteria have been checked patients will be randomized: group 1: immediate angiography patients randomized to group 1 will be transported to the catheterization laboratory as soon as possible after hospital admission for evaluation of coronary anatomy. group 2: delayed/selective angiography upon hospital admission, patients assigned to group 2 will first be transported to the icu for further evaluation and stratification of ohca etiology. further triage will depend on the results of clinical examination and objective testing and will be left to the individual physician according to clinical judgment. depending on clinical circumstances, further management may comprise medical therapy, laboratory testing, imaging such as echocardiography and/or computed tomography, hemodynamic or neurological monitoring, the initiation of therapeutic hypothermia or other measures of intensive care. if a high likelihood of an acute coronary trigger for ohca persists (i.e. inconclusive results from clinical evaluation with ongoing suspicion of an acute coronary event, etc.), the treating physician may proceed to coronary angiography after a delay of 24h after the onset of cardiac arrest. vital status will be assessed at 30 days, 6 and 12 months after randomization by direct questioning if the patient is still hospitalized or structured telephone interview. clinical events will be verified by original source data. at 6 and 12 months, quality of life will be assessed by the the euroqol 5d questionnaire. the tomahawk trial is supported by the deutsches zentrum für herz-kreislauf-forschung (dzhk).

Eligibility criteria:
inclusion criteria: * documented resuscitated ohca of possible cardiac origin and return of spontaneous circulation * age ≥30 years * informed consent exclusion criteria: * st-segment elevation or new left bundle branch block * no return of spontaneous circulation upon hospital admission * severe hemodynamic or electrical instability requiring immediate coronary angiography/intervention (delay clinically not acceptable) * obvious extra-cardiac etiology such as traumatic brain injury, primary metabolic or electrolyte disorders, intoxication, overt hemorrhage, respiratory failure due to known lung disease, suffocation, drowning * in-hospital cardiac arrest * known or likely pregnancy * participation in another intervention study
trial of antiseptic irrigation for pleural infection

Conditions: Empyema, Pleural

Summary: pleural antiseptic irrigation (pai) is used in conjunction with open drainage for treating adults with chronic post-thoracotomy empyema. the antiseptic povidone-iodine can safely be instilled into the pleural cavity for the purpose of pleurodesis and has recently been described for pleural irrigation in the acute management of paediatric pleural infection with good outcomes. a recent case report demonstrated the safe use of povidone-iodine pleural irrigation in a patient with complex pleural empyema with successful medical management. in a previous pilot study, antiseptic irrigation led to less referral to surgery and shorter length of hospital stay in comparison to no irrigation. this study aims to investigate the effect of antiseptic pleural irrigation (using povidone iodine) on the inflammatory response in adults patients with pleural infection in comparison to irrigation with normal saline alone. a reduction in the systemic inflammatory response can be inferred to correlate with reduction in the infection burden in the pleural space.


Eligibility criteria:
inclusion criteria: * adults (18 year-old or more) * pleural infection diagnosed by: the presence of pus in the pleural space, or any of the following in the setting of acute lower-respiratory tract infection symptoms: pleural fluid ph\<7.2 or pleural fluid glucose \<40 mg/dl, positive gram stain or culture from pleural fluid * predominantly unilocular pleural collection treated with chest tube drainage * acute response at presentation as evidenced by fever (\>37.80c) and/or blood leucocytosis (\>11x103/mm3) and/or high serum c-reactive protein, crp (\>50 mg/l) exclusion criteria: * known or suspected thyroid disease * allergy to iodine * persistent large collection on follow-up imaging 24-48 post tube insertion that is deemed to require additional interventions (e.g., another drainage procedure, intrapleural fibrinolytic) * evidence or suspicion of broncho-pleural fistula (suspected when there is air-fluid level without previous intervention, or if the participant is coughing large volume of purulent sputum that is physically similar to drained pleural fluid) * tuberculous, post-operative or post-haemothorax pleural infections