Kornimate/medical-research-clean huggingface dataset:
clinical evaluation of a new high-speed and high-resolution intravascular ultrasound system

Conditions: Percutaneous Coronary Intervention; Coronary Artery Disease; Chronic Total Occlusion of Coronary Artery; Left Main Coronary Artery Disease

Summary: insight lifetech intravascular ultrasound diagnostic system (referred to as insight lifetech ivus system below),is a new high-speed and high-resolution device for clearly defining vessel architecture and plaque morphology, providing quantitative and qualitative assessment of coronary arteries. besides, ivus has already an established role in guidance and optimization of percutaneous coronary intervention. this study will compare the differences, if any, between the intravascular ultrasound(ivus) results measured by the two different ivus diagnostic systems.

many studies have reported that ivus is an accurate method for determining the size of the target vessel undergoing stent implantation , and the optimal stent deployment (complete stent expansion and apposition and lack of edge dissection or other complications after implantation). the novel 60 megahertz(60mhz) high-definition ivus has evolved as a next-generation ivus imaging technology to provide higher image resolution than conventional 40 megahertz(40mhz) ivus but with sufficient imaging depth preserved for the assessment of the entire vessel wall structure. insight lifetech ivus system includes truevision ivus diagnostic catheter and vivoheart ivus diagnostic console. it is a novel device with high speed, high resolution, and high image acquisition rate enabling high-speed pullback imaging up to 10mm/sec. this study is a prospective, multi-center, randomized, single-blind, controlled study with the primary target of investigating the differences, if any, between ivus measurement results by the insight lifetech ivus system and boston scientific ivus system, imaging catheter of which was available at 40mhz during the study. other purposes included analyzing the feasibility of the insight lifetech ivus system's high-speed pullback during the ivus assessment. a total of 130 patients will be recruited from 5 centers in china.

Eligibility criteria:
inclusion criteria: * age: 18 years and older; * understand and willing to sign the informed consent form; * clinical evaluation shows that the coronary artery stent implantation and the intravascular ultrasound(ivus) guidance is required. exclusion criteria: * unable to understand or unwilling to sign the informed consent form; * clinically diagnosed with severe coronary artery spasms; * contraindicated to percutaneous coronary intervention (pci); * presence of any other factor that the investigator deems is unsuitable for enrollment or completion of this study.

Keywords: high-speed, high-resolution ivus
evaluation of the kinesiology taping effectiveness in the treatment of lumbar spine pain

Conditions: Low Back Pain; Young Adult; Therapy

Summary: lumbar spine pain syndromes are one of the most common pain conditions in our society. the purpose of kinesiotaping is to normalize muscle function, improve blood and lymph flow, reduce pain, improve proprioception, promote tissue healing and restore normal tissue function. today, this method is used in many fields of medicine. its primary purpose is to support the musculoskeletal system by using various types of applications. there is a lack of publications in the global literature on the effect of kinesiotaping of the external oblique muscles on lumbar spine pain. the main objective of this study is to evaluate the effectiveness of kinesiology taping in the treatment of lumbar spine pain in individuals under 30 years of age.

back pain occurs in people of all ages, regardless of their job. both blue-collar and white-collar workers are exposed to strain and pain in the lumbar spine. the presence of pain is also promoted by low physical activity, poor motor habits, as well as stress. there are numerous factors affecting the quality of life in patients with lower back pain. these include degree of pain, physical fitness, individual factors, degree of social support, and a potential for adapting forces to match constantly changing conditions. the contemporary functional model of lumbar spinal muscles divides them into local stabilizers, single-joint global stabilizers, and multi-joint global stabilizers. the abdominal external oblique muscles are classified as global stabilizers. they generate force to control range of motion and allow limitation of that range (eccentric control), and functionally control rotation in all movements, regardless of the load acting on the spine. the main objective of this study is to evaluate the effectiveness of kinesiology taping in the treatment of lumbar spine pain in individuals under 30 years of age.

Eligibility criteria:
inclusion criteria: * participants' age between 18 and 30, * the presence of pain in the lumbar region of the spine, * participants who have not been using non-steroidal anti-inflammatory drugs (nsaids) for at least one week prior to study entry, * no contraindications to the use of dynamic kinesiology taping patches, * informed, written consent to participate in the study. exclusion criteria: * status of the post lumbar spine surgery, * subjects who have had a spinal injury within 6 months prior to the start of the study, * neoplastic diseases, * congenital structural pathologies of the spine, * allergy to the adhesive substance of kinesiology taping or paper patch, * being a physiotherapy student.
left vs right radial approach in the setting of primary percutaneous coronary intervention for st-elevation myocardial infarction

Conditions: Transradial Approach, Primary PCI, ST-segment Elevation Myocardial Infarction

Summary: outcomes of patients with acute st-elevation myocardial infarction (stemi) are directly related to reperfusion time. effect of transradial approach (left vs right) on reperfusion time has not been fully studied for setmi patients undergoing primary percutaneous coronary intervention (pci). the aim of this study was to randomly investigate the efficacy and safety of left radial approach for primary pci in stemi patients compared with right radial approach.

the investigators will enroll consecutively for 3 years all stemi patients undergoing primary pci. patients will be included within 12 hours of symptom onset for primary pci. patients will be excluded if they are in cardiogenic shock.

Eligibility criteria:
inclusion criteria: all consecutive patients with st-segment elevation myocardial infarction within 12 hours of symptom onset for primary pci. exclusion criteria: patients are excluded if they were in cardiogenic shock.

Keywords: transradial approach, primary pci, st-segment elevation myocardial infarction
efficacy and safety of teprenone in patients with acute gastritis, acute gastric lesion of chronic gastritis with acute exacerbation or gastric ulcer

Conditions: Acute Gastritis; Gastric Ulcer

Summary: this is a self-controlled, open, multiple-center clinical trial.


Eligibility criteria:
inclusion criteria 1. age is over 18 years old , men or women 2. erosive lesions or flat lesions with thin white coating in acute gastritis, acute stage of chronic gastritis with over three lesions (including three lesions) by endoscopy prior to study in 3 days or diagnosed by clinical symptoms and signs; 3. signed the informed consent forms. exclusion criteria 1. patients without inclusion criteria 2. patients with significant cardiovascular, pulmonary, hepatic, renal or hemopoietic system primary disease 3. patients with other digestive diseases. 4. patients with operation on stomach and duodenum. 5. patients administered with nonsteroidal anti-inflammatory drugs (nsaids) and corticosteroids 6. patients with severity trauma, surgery, infection and shock. 7. patients with any kind of tumor 8. women either pregnant or breast feeding

Keywords: teprenone safety efficacy acute gastric lesion chronic gastritis
responses to chemotherapy of patients with non-small cell lung cancer harboring a known somatic activating her2 mutation

Conditions: Lung Cancer

Summary: this chart review describe the response to systemic chemotherapy of patients with non-small cell lung cancer (nsclc) harbouring a known somatic activating human epidermal growth factor receptor 2 (her2) mutation. the analysis of this data will provide an initial description of the response to systemic chemotherapy in patients with nsclc harboring an activating her2 mutation in order to inform the design and powering of future randomized controlled clinical trials of her2-directed therapy.


Eligibility criteria:
inclusion criteria: * patients with advanced nonsmall-cell lung cancer * known her2 exon-20 insertion * treated with chemotherapy and/or her2-targeted drugs exclusion criteria: * none
the effects of non harmonic and white noise on human pain sensitivity: a study of healthy volunteers

Conditions: Pain

Summary: study the effects of 60db and 80db white noise, 50-70db and 70-90db non harmonic tones on the basic pain threshold of subjects, including the threshold and tolerance of electrical stimulation pain,the threshold and tolerance of cold pain stimulation, and the threshold and tolerance of tenderness stimulation.


Eligibility criteria:
inclusion criteria: * between the ages of 18 and 35, regardless of gender * no serious chronic diseases * there is no self-reported history of chronic opioid drug use or neuropathy exclusion criteria: * a history of alcohol or drug abuse * pregnant or lactating * severe cardiovascular, kidney, or liver diseases

Keywords: noise pain
effect of hyaluronic acid in the treatment of periodontal pockets

Conditions: Chronic Periodontitis With Infra-bony Defects

Summary: the aim of this study is to evaluate the effect of hyaluronic acid in the surgical treatment of periodontal pockets in people with gum disease. this research consists of clinical and radiographic studies. participants should have symmetric periodontal pockets in the upper or lower jaw. participants will be treated surgically using hyaluronic acid on one side of the jaw. clinical indexes and radiographic cone-beam computed tomographic (cbct) images will be taken for each participant before surgical treatment and 12 months after surgical treatment.

the aim of this study is to evaluate the effect of hyaluronic acid in the surgical treatment of infra-bony pockets in chronic periodontitis patients. this research consists of clinical and radiographic studies. 1- the clinical study: is a randomized controlled trial with a split mouth technique. chronic periodontitis patients with infra-bony pockets will be collected from the department of periodontics in faculty of dentistry - damascus university. participants should have symmetric infra-bony pockets in the upper or lower premolar area with pocket probing depth more than 6 mm. participants will be treated surgically using open flap curettage. open flap curettage will be done for each patient in both sides of the jaw, but hyaluronic acid will be used in one of the two sides with random allocation of the site that in going to be treated with hyaluronic acid. plaque index, gingival index, bleeding on probing, tooth mobility index, pocket probing depth and clinical attachment loss will be taken for each participant four times; before surgical treatment, 3 months, six months and 12 months after surgical treatment. radiographic study: will be done using cbct radiography technique. cbct will be taken for each participant before and after 12 months of surgical treatment. different distances, vertical bone fill and depth of infra-bony defect will be measured on cbct images.

Eligibility criteria:
inclusion criteria: * patients with chronic periodontitis * symmetric infra-bony defects with periodontal pocket depth more than 6 mm. * in upper or lower premolar area. * all participants will be collected from patients attending department of periodontology - faculty of dentistry for periodontal disease treatment. * males and females. * 35-65 years old. * systematically healthy. * accepting to participate in the study. informed written consent will be required. exclusion criteria: * a history of previous scaling and root planning in the last 6 months * smokers * pregnant women * diabetes mellitus

Keywords: hyaluronic acid infra-bony defects chronic periodontitis experimental radiographic clinical periodontal surgical treatment open flap curettage
evaluation of efficacy and safety of tablets of paracetamol, dimethindene maleate and phenylephrine hydrochloride in reducing symptoms of common cold and flu

Conditions: Upper Respiratory Tract Infection; Nasal Congestion; Rhinorrhea; Sneezing

Summary: the study is a clinical evaluation of an over the counter (otc) combination product containing paracetamol (500 mg), dimethindene maleate (1 mg), phenylephrine hydrochloride (10 mg) compared to paracetamol (500 mg) alone in the treatment of nasal congestion, rhinorrhea, sneezing and other symptoms due to upper respiratory tract infection (urti).


Eligibility criteria:
* inclusion criteria: • acute urti, diagnosed by a health care professional at the study site, with the following symptoms having started within 72 hours before the screening/baseline visit: nasal congestion, sneezing, and rhinorrhea. * exclusion criteria: * use of other investigational drugs within 30 days or 10 half-lives before enrollment, whichever is longer. * history of or known hypersensitivity to any of the study drugs, excipients or to drugs of similar chemical classes. other protocol-defined inclusion/exclusion criteria may apply

Keywords: paracetamol dimethindene maleate phenylephrine hydrochloride cold and flu symptoms
evaluation of blastocyst morphology and quality in patients with embryo transfer at the blastocyst stage

Conditions: Infertility

Summary: in this prospective study, the investigators aim to investigate the role of trophectoderm cells and inner cell mass cells on pregnancy outcomes in blastocyst transferred in-vitro fertilization pregnancy. the investigators will support findings with bilateral uterine artery doppler measurements to be made between the 11th and 14th weeks of pregnancy.

patients scheduled for thawed blastocyst transfer between may 2022 and december 2022 in akdeniz university hospital center for reproductive endocrinology and assisted reproduction will be included in the study. embryos that have reached the blastocyst stage after the icsi procedure will be examined by a single experienced embryologist using the alpha istanbul consensus evaluation system. this system includes separating the blastocyst from the zona pellucida - hatching (grade 1,2,3,4), the size of icm and arrangement (grade a, b, c), and the number of te cells and arrangement (grade a, b, c). among the embryos whose quality is determined, the best quality embryo belonging to the patient will be transferred single, patients who develop pregnancy after the transfer will be called for follow-ups for uterine artery doppler measurements to evaluate uteroplacental flow between 11and 14 weeks, and their doppler measurements will be recorded. by contacting the patients with the phone numbers recorded at the time of the first visit, the weeks of birth, baby weight, gender, and complications that developed during the pregnancy (abortion, preeclampsia, eclampsia, fetal growth restriction, oligohydramnios, polyhydramnios, gestational diabetes mellitus and antenatal bleeding) will be recorded. in case the related relationship can be revealed, the risk situations in terms of complications are determined before the transfer, and it is aimed to increase the number of live births together with the risk-based management in the follow-up and screening programs.

Eligibility criteria:
inclusion criteria: * exogenous hormone preparation of the endometrial lining * single embryo transfer * embryo transfer at the blastocyst stage exclusion criteria: * double embryo transfer * patients who underwent embryo transfer at the cleavage stage * \>15% loss of embryo viability during embryo thawing * patients whose data could not be accessed after follow-up or delivery

Keywords: embryo morphology frozen - thawed embryo transfer
study evaluating dvs-233 sr in adult outpatients with major depressive disorder

Conditions: Major Depressive Disorder

Summary: primary objective: to compare the efficacy and safety of dvs-233 sr versus placebo treatment in reducing the relapse rate of depressive symptoms in subjects with major depressive disorder (mdd), and to compare the percentages of relapse in terms of time to relapse between dvs-233 sr and placebo treatment groups by using survival analysis. secondary objective: to assess the response of subjects on dvs-233 sr versus placebo for the clinical global evaluation, functionality, general well-being, pain, and absence of symptoms (hamilton psychiatric rating scale for depression, 17-item \[ham-d17\] \< 7).


Eligibility criteria:
inclusion criteria in the open-label phase: * outpatients * men and women 18 to 75 years of age, inclusive. sexually active women participating in the study must use a medically acceptable form of contraception (medically acceptable forms of contraception include oral contraceptives, injectable or implantable methods, intrauterine devices, or properly used barrier contraception) * subjects must have a primary diagnosis of mdd based on the criteria in the diagnostic and statistical manual of mental disorders, 4th edition (dsm-iv), single or recurrent episode, without psychotic features (if other allowable psychiatric diagnoses are present, mdd must be the predominant psychiatric disorder present.) exclusion criteria: * treatment with dvs-233 sr at any time in the past * treatment with venlafaxine (immediate release \[ir\] or er) within 90 days of study day 1 * known hypersensitivity to venlafaxine (ir or er)
jump: mr simulation for radiation therapy master protocol

Conditions: Prostate Cancer; Recurrent Adenocarcinoma; Liver Cancer; Head and Neck Cancer

Summary: this is a master protocol for a prospective phase i-ii study evaluating feasibility and efficacy of incorporating magnetic resonance imaging (mri) simulation into the planning of radiation treatments.

this is a phase i/ii clinical trial. a phase i clinical trial tests the feasibility and safety of an investigational intervention. "investigational" means that the process targeting high doses of radiation to the tumor based on mri is still being studied. this research study is a feasibility study, which means it is the first-time investigators at this institution are examining this type of mr-guided dose planning. the u.s. food and drug administration (fda) has cleared mri planning for use. * in phase i of this study, will prospectively determine the feasibility of using an mri simulator to plan radiation therapy. * in phase ii, the efficacy of adjusting rt based on mri simulation will be explored, either by utilizing an mri-simulation and synthetic ct to plan treatment or by dose-painting based on functional mri data

Eligibility criteria:
inclusion criteria: * participants must have a confirmed malignancy requiring radiation therapy. * age: 18 years or older * ecog performance status ≤2 (karnofsky ≥60%, see appendix a) * ability to understand and the willingness to sign a written informed consent document. * disease-specific eligibility criteria will be specified in the appropriate subprotocol. exclusion criteria: * for mri involving contrast, history of allergic reactions attributed to gadolinium based iv contrast. note: if patient will not receive contrast, this is not applicable * participants who cannot undergo an mri * disease-specific exclusion criteria will be specified in the appropriate subprotocol

Keywords: prostate cancer recurrent adenocarcinoma liver cancer head and neck cancer
a study of the efficacy of the code stroke in spain

Conditions: Stroke, Acute

Summary: code stroke is a system for the rapid identification, pre-notification and transport of acute ischemic stroke patients. the objective of this study was to define quality indicators and to compare treatment outcomes in hospitals where code stroke has been implemented and hospitals without the use of code stroke (control patients).

in a first step qualitative technique has been conducted to define treatment quality indicators of acute ischemic stroke patients. in a second step a prospective study is conducted to collect data of 240 inpatients from two groups of hospitals. two hospitals applying code stroke (n= 120) and four hospitals non-applying code stroke procedure (n=120). a consecutive sampling method will be conducted. inclusion criteria: acute ischemic stroke patients treated in the hospitals during the field study. the referral to the hospital could be from primary care, emergency unit of other hospital. patients will enroll after inform consent. a singer-blind- research method will applied. quality indicators defined in the first phase will be applied and comparisons will be realized using anova.

Eligibility criteria:
inclusion criteria: * acute ischemic stroke in-patients exclusion criteria: * patients who refuse participate

Keywords: acute ischemic stroke quality
anorexia nervosa and brain in adolescence

Conditions: Anorexia Nervosa

Summary: aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in adolescence.

anorexia nervosa is severe mental health problem with increased incidence rates in adolescence. etiology of anorexia nervosa is still mostly unkonwn. adolescence is also critical period of brain development. aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in both acute and remission state of anorexia nervosa in adolescence. study group are young anorexia nervosa patients, and control group are healthy same-aged students. research methods include non-invasive brain imaging methods such as transcranial magnetic stimulation (tms), and magnetic resonance imaging (mri). other research methods are assessment of body composition, laboratory tests, self-rated questionnaires and psychiatric interview.

Eligibility criteria:
inclusion criteria: study group: 1) age 16-19 years, 2) bmi below 17.5, 3) diagnosis: anorexia nervosa or atypical anorexia nervosa 4) diagnosed within last two years. inclusion criteria. control group : 1) age 16-19 years, 2) bmi over 19.0, 3) no lifetime obesity (bmi over 30) nor eating disorder. exclusion criteria: 1) glucose metabolism disorder or any chronic medical disorder, or medicine with possible effects on neurotransmitters, 2) previous mental health problem (excluded anorexia nervosa or atypical anorexia nervosa in study group), 3) smoking, nicotine products, alcohol or any other substance abuse or dependence, 4) contraindication for used brain imaging method.