Kornimate/medical-research-clean huggingface dataset:
how seasons affect kidney health in post-menopausal females

Conditions: Postmenopausal; Female

Summary: the investigators are assessing how seasonal changes affect kidney function biomarkers in post-menopausal women, an understudied group. while heat stress can reduce kidney function, previous research has not accounted for physical activity, diet, hydration, or sun exposure.

intense heat stress on the body can reduce kidney function. a recent study reported that blood markers of kidney function are lower among people in hotter climates. however, these data did not consider physical activity, food intake, fluid intake, time spent outdoors, or exposure to sunlight. therefore, the investigators invite participants to help determine whether there are seasonal changes in kidney function biomarkers. this will also help the investigators understand if physical activity, food intake, fluid intake, time spent outdoors, or exposure to sunlight affect kidney function biomarkers between seasons. the investigators are studying female adults post-menopause since they are an understudied group.

Eligibility criteria:
inclusion criteria: * female aged ≥55 years old * self reported as at least one year post-menopause * live in tallahassee, florida, or the surrounding area exclusion criteria: * have a bmi of ≥30 kg/m2 * systolic blood pressure of ≥140 and/or diastolic blood pressure ≥90 mmhg * self reported current or recent (regular use within the past six months) use of a diuretic medication * self reported: uncontrolled cardiovascular, respiratory, neurological, renal, liver, or metabolic health condition * current or recent (regular use within the past six months) use of tobacco, nicotine, nonsteroidal anti-inflammatory products * no regular (≥once per week) purposeful heat exposure (e.g., sauna, spa, etc.)

Keywords: kidney health post-menopause heat stress hydration older adults aging postmenopausal women
pd-1 knockout ebv-ctls for advanced stage epstein-barr virus (ebv) associated malignancies

Conditions: Stage IV Gastric Carcinoma; Stage IV Nasopharyngeal Carcinoma; T-Cell Lymphoma Stage IV; Stage IV Adult Hodgkin Lymphoma; Stage IV Diffuse Large B-Cell Lymphoma

Summary: this study will evaluate the safety of pd-1 knockout ebv-ctl cells in treating ebv (epstein-barr virus) positive advanced stage malignancies. blood samples will also be collected for research purposes.

this is a study of crispr-cas9 mediated pd-1 knockout-t cells from autologous origin. patients are assigned to receive 4 circles of cell therapy. the safety and clinical response are evaluated. biomarkers and immunological markers are also monitored.

Eligibility criteria:
inclusion criteria: * pathologically verified stage iv gastric carcinoma, nasopharyngeal carcinoma and lymphoma with measurable lesions (at least one measurable lesion or the immunotherapy) * pathologically verified as ebv positive malignancies * human leukocyte antigen (hla) genotypes: hla-a02, hla-a24 or hla-a11 genotypes * progressed after standard treatment or the patients refused to accept the standard treatment * performance score: 0-1 * expected life span: \>= 3 months * toxicities from prior treatment has resolved. washout period is 1 months * major organs function normally * women at pregnant ages should be under contraception * willing and able to provide informed consent exclusion criteria: * patients with possible drug allergy of immunotherapy * patients with active bacterial or fungal infections * coagulopathy, or ongoing thrombolytics and/or anticoagulation * blood-borne infectious disease, e.g. hepatitis b, hepatitis c and hiv * history of coronary artery disease, asthma, or vascular disease or other disease inappropriate for treatment deemed by treating physician * with other tumors except for in situ cervical cancer, treated squamous cell carcinoma and bladder cancer (ta and tis) or other malignancies that have been treated with radical therapy (at least for 5 years before the enrollment) * with other immune diseases, or chronic use of immunosuppressants or steroids * pregnant and lactating women * compliance cannot be expected * other conditions requiring exclusion deemed by physician

Keywords: pd-1 crispr cas9 ebv advanced stage malignancies
evaluation of functionality of amputees according to the medicare functional k classification system

Conditions: Amputation; Amputation; Traumatic, Leg, Lower

Summary: the aim of our study is; to evaluate the functionality of lower extremity unilateral amputees, to ensure that the results of the medicare functional k classification system, which provides subjective data for the evaluator, become an objective evaluation method and to determine the functional levels of unilateral amputees; to create an objective data set by applying one-leg standing test, ten meter walking test, l test, figure-8 walking test, joint range of motion, amputee mobility estimator scale, houghton scale and joint position sense evaluation tests.

the study will be carried out at medicom orthosis prosthesis center and ortoport prosthesis application center. the study will be conducted in accordance with the principles of human experimentation as defined in the declaration of helsinki. for this purpose, amputees who will participate in the study will be given detailed information about the study and will have to sign an informed consent form. 20 unilateral lower extremity amputations will be taken. the inclusion and exclusion criteria of the study are as follows; inclusion criteria; unilateral lower extremity amputation, using a prosthesis, being literate, being between the ages of 18-65, having a healthy stump, using your current prosthesis in daily living activities, exclusion criteria; bilateral lower extremity amputation, unilateral or bilateral amputation of the upper extremity, having a cognitive or mental problem, having serious hearing and vision problems, the individual has an orthopedic disease other than amputation, having an uncontrolled neurological and systemic systemic disease, spps 25.0 (statistical package for the social sciences) statistical package program will be used to evaluate the data. when the differences between two groups are desired to be evaluated, "student's t test" is used if it meets the parametric test prerequisites; if not, the "mann whitney-u test" will be used.

Eligibility criteria:
inclusion criteria: * unilateral lower extremity amputation, * being using a prosthesis, * being literate, * being between the ages of 18-65, * having a healthy stump, * using your current prosthesis in daily living activities, exclusion criteria: * bilateral lower extremity amputation * unilateral or bilateral amputation of the upper extremity, * having a cognitive or mental problem, * having serious hearing and vision problems, * the individual has an orthopedic disease other than amputation, * having an uncontrolled neurological and systemic systemic disease,
family networks project study one: an efficacy study of stepping stones triple p for children under age two

Conditions: Prevent Child Maltreatment

Summary: the purpose of the project is to assess the initial efficacy of stepping stones triple p-positive parenting program (sstp) with parents of children below age two with developmental disabilities to strengthen families and prevent child maltreatment.

this study is an initial efficacy trial of sstp for parents of children below age 2. the target population consists of 50 families of young children ages 11-23 months with developmental disabilities who are eligible to receive idea part c (individuals with disabilities education act part c) services in one region of south carolina. families will be randomly assigned to one of two conditions (1) idea part c services as usual or (2) idea part c services plus sstp. project goals are to strengthen parent competence, enhance parent confidence, and strengthen child social, emotional and behavioral functioning. ultimately, this should result in a reduced likelihood of child maltreatment

Eligibility criteria:
inclusion criteria: * child age between 11 and 23 months of age * child eligible for idea part c services * parent english speaking * parent willing to allow in-home services exclusion criteria: * disability requiring extensive out of home treatment

Keywords: prevention evidence-based parenting intervention children disabilities idea part c stepping stones triple p
efficacy and safety in patients with primary iga nephropathy who have completed study nef-301 (nefigard-ole)

Conditions: Primary IgA Nephropathy

Summary: this is a phase 3b, multicenter, open-label extension (ole) study to evaluate the efficacy and safety of nefecon treatment in patients with igan who have completed the phase 3 study nef-301 and continue to be treated with a stable dose of ras inhibitor therapy (aceis and/or arbs). patients who previously received nefecon in study nef-301 will receive retreatment, whereas patients who previously received placebo in study nef-301 will be treatment naïve to nefecon.

this is a phase 3b, multicenter, open-label extension (ole) study to evaluate the efficacy and safety of nefecon treatment in patients with igan who have completed the phase 3 study nef 301 and continue to be treated with a stable dose of ras inhibitor therapy (aceis and/or arbs). patients who previously received nefecon in study nef-301 will receive retreatment, whereas patients who previously received placebo in study nef-301 will be treatment naïve to nefecon. during study nef-301 ole, the patients and investigators will remain blinded to treatment given in study nef-301. during study nef-301 ole, patients will receive nefecon for a 9-month period. the dose may be reduced if clinically relevant adverse events (aes) develop during the 9-month treatment period that the investigator considers related to the study drug and that mandate dose reduction. patients will remain on a stable dose of ras inhibitor therapy (aceis and/or arbs) throughout the study. the patient will come for a follow-up visit at 12 months after first dose.

Eligibility criteria:
inclusion criteria: 1. patients that completed study nef-301 2. on a stable dose of ras inhibitor therapy (aceis and/or arbs) at the maximum allowed dose or maximum tolerated dose according to the 2012 kdigo guidelines 3. willing and able to provide written informed consent. 4. upcr equal to or more than 0.8 g/gram 5. egfr equal to or more than 30 ml/min per 1.73 m2 using the chronic kidney disease epidemiology collaboration (ckd-epi) formula. exclusion criteria: 1. systemic diseases that may cause mesangial iga deposition. 2. patients who have undergone a kidney transplant; 3. patients with presence of other glomerulopathies and/or nephrotic syndrome 4. patients with acute, chronic, or latent infectious disease including hepatitis, tuberculosis (tb), human immunodeficiency virus (hiv), and chronic urinary tract infections; 5. patients with liver cirrhosis, as assessed by the investigator; 6. patients with a diagnosis of type 1 or type 2 diabetes mellitus which is poorly controlled 7. patients with history of unstable angina, class iii or iv congestive heart failure, and/or clinically significant arrhythmia, as judged by the investigator; 8. patients with unacceptable blood pressure control defined as a blood pressure consistently above national guidelines for proteinuric renal disease, as assessed by the investigator. 9. patients with diagnosed malignancy within the past 5 years.
multicentre, randomised phase iii study of the efficacy and safety of hetrombopag olamine in idiopathic thrombocytopenic purpura (itp) patient

Conditions: Idiopathic Thrombocytopenic Purpura

Summary: a multicentre, randomised, double-blind,4-stages phase iii study enrolled 414 patients with chronic, previously treated itp. dosage could be adjusted (2.5\~.75 mg/day) to maintain platelet counts 50\~250×109/l


Eligibility criteria:
inclusion criteria: 1. confirmed diagnosis of itp ≥6 months;platelets \<30×109/l. 2. no evidence of other causes of thrombocytopenia. 3. subjects who are refractory or have relapsed after at least one prior itp therapy. 4. previous therapy for itp including rescue must have been completed at least 2 weeks prior to randomization. 5. subjects treated with maintenance immunosuppressive therapy must be receiving a dose that has been stable for at least 1 month. 6. pt result no exceed normal by more than ±3s,aptt result no exceed normal by more than ±10s. 7. signed informed consent. exclusion criteria: 1. patients with any prior history of arterial or venous thrombosis，or diagnosis as thrombophilia. 2. subjects diagnosed with tumor. 3. have pre-existing cardiac disease within the last 3 months.no arrhythmia known to increase the risk of thrombolic events (e.g. atrial fibrillation), or patients with a corrected qt interval (qtc) \>450msec or qtc \>480 for patients with a bundle branch block. 4. female subjects who are nursing or pregnant at screening or pre-dose on baseline. 5. subjects who have previously received eltrombopag or any other thrombopoietin receptor agonist within 30 days . 6. subject has consumed aspirin, aspirin-containing compounds, salicylates, anticoagulants, quinine or non-steroidal anti-inflammatories (nsaids) for \>3 consecutive days within 2 weeks of the study start and until the end of the study. 7. any laboratory or clinical evidence for hiv infection.any clinical history for hepatitis c infection; chronic hepatitis b infection; or any evidence for active hepatitis at the time of subject screening. 8. alt\> 1.5 x upper limit of normal (uln), ast\> 3 x upper limit of normal (uln)) dbli\> 1.2 x upper limit of normal (uln),scr\> 1.2 x upper limit of normal (uln) 9. the subject has participated in other clinical trial within the 3 months prior to randomization.

Keywords: itp
oscillation mechanics of the respiratory system asbestos exposed: early diagnosis

Conditions: Asbestosis

Summary: inhalation of dust containing asbestos results in a process of interstitial pulmonary fibrosis called asbestosis. the forced oscillation technique (fot) evaluates the respiratory mechanics describing resistive, elastic and inertial properties. we believe that this technique may contribute to the early diagnosis of asbestosis.

the aims of this study were (1) to use the fot to analyze how respiratory mechanics is affected in patients with asbestos exposed, (2) to identify the best fot parameters for the diagnosis of respiratory changes in these patients (3) assess whether the presence of obstructive changes is associated with the smoking habit.the control group (cg) included 24 subjects with normal spirometric data and without a history of smoking or pulmonary disease formed by workers and students uerj and fiocruz. volunteers with asbestos exposure were from the department of cesteh/ fiocruz, totaling 24 exposed and 7 with diagnoses of asbestosis. the diagnosis of asbestosis was established based on a history of substantial exposure to asbestos dusts and compatible radiological features, together with exclusion of other competing diagnoses. the tests included a standardized questionnaire on respiratory symptoms, clinical evaluation; plain radiography of the chest; fot, plethysmography and spirometry, in that order.

Eligibility criteria:
inclusion criteria: * diagnosis of asbestosis exclusion criteria: * other diseases

Keywords: forced oscillation tecnique lung function asbestosis
spinal cord stimulation assisted by motor rehabilitation training for restoring motor function after spinal cord injury

Conditions: Spinal Cord Injuries

Summary: interventional prospective longitudinal on the evaluation of spinal cord stimulation (scs) assisted by motor rehabilitation training for restoring motor function in patients with spinal cord injury (sci). the investigators will enroll ten research participants with clinically incomplete/complete sci (patients with paraplegia or severe paraparesis) who will undergo scs subsequently assisted by motor rehabilitation training for restoring motor function at irccs ospedale san raffaele, milan, italy. the main goal of the project is to evaluate the improvement in motor function generated by the combination of scs and locomotor training. in line with recently published studies, the investigators propose that daily locomotor training in the presence of scs with continuous stimulation parameters setting will enable the sci individuals to stand and step independently while bearing full weight.


Eligibility criteria:
inclusion criteria: * diagnosis of sci from at least one-year post injury; * complete or incomplete spinal cord damage (asia grade a, b or c) conditioning chronic neuropathic pain and motor impairment * age \> 18 years; * indication to spinal cord stimulation surgery for chronic pain; * be unable to stand or step independently; * no current anti-spasticity medication regimen; * no botox injections in the prior 3 months; * evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the study; * willingness and ability to comply with scheduled visits and other trial procedures. exclusion criteria: * any person unable to lie still within the environment of the mri scanner for the required period to perform the study and those where mri scanning is contraindicated (i.e. metal clips, claustrophobia); * pregnancy or breastfeeding; * any significant psychiatric disease; * use of illicit drugs; * unstable medical condition without cardiopulmonary disease or dysautonomia that would contraindicate standing or stepping; * painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure sore, or urinary tract infection that might interfere with stand or step training;

Keywords: motor restoration chronic pain rehabilitation neuromodulation
effect of active vs. passive voiding trials on time to discharge, urinary tract infection, and urinary retention

Conditions: Urinary Retention; Urinary Tract Infections

Summary: urinary retention is a common problem, particularly in hospitalized patients. when a foley catheter is removed, a patient must be monitored for urinary retention. the usual method is a passive voiding trial where the catheter is removed, the bladder fills with urine and the patient is monitored for voiding over approximately 6 hours. another option is an active voiding trial where the bladder is filled with saline before the catheter is removed and the patient is immediately assisted to void. this study seeks to determine the effect of active vs passive voiding trials on time to hospital discharge, rate of urinary tract infections, and rate or urinary retention in the general hospitalized population.

the intervention to be tested is an active voiding trial, where the bladder is filled with saline before the catheter is removed and the patient is immediately assisted to void.

Eligibility criteria:
inclusion criteria: * admission to one of three hospital units at the university of virginia (5 central, 6 west, or the short stay unit) * patient has a foley urethral catheter in place * the physician has ordered the foley urethral catheter to be discontinued * 18 years of age and older exclusion criteria: * age less than 18 years * prisoners * women who are pregnant
sms counseling on gestational diabetes

Conditions: Gestational Diabetes

Summary: the use of technology-based education and counseling services in the self-management of gestational diabetes contributes to better control of blood sugar levels, motivation and increased self-efficacy in women. therefore, this study was planned as interventional research to determine the effect of sms counseling given to individuals with gestational diabetes on self-efficacy and knowledge levels. this study was conducted descriptively with 95 patients with gestational diabetes who were treated in the endocrine service of a university hospital between august 15, 2021 and april 24, 2022. personal information form created by the researchers, the self-efficacy scale in gestational diabetes, and diabetes knowledge scale were used to collect data.


Eligibility criteria:
inclusion criteria: * diagnosed with gestational diabetes, * being in the 30th week of pregnancy, * having a smartphone, * volunteering to participate in the study, * having no communication problems, * having no psychiatric problems exclusion criteria: * being non-literate, * having communication problems (hearing or sight), * not volunteering to participate in the research

Keywords: gestational diabetes mellitus, self-efficacy, sms counseling.
sodium management in acute neurological injury

Conditions: This Study is to Understand the Current Practice of Sodium Management in Acute Neurological Injury

Summary: this multicenter, observational, study will enroll severe neurologically injured patients both prospectively and retrospectively. the aims are to identify the percent of neurocritical care patients with sodium levels ≤ 135 meq/l, describe treatment strategies employed, determine the correlation of clinical factors (i.e. gcs, icp) with serum sodium concentrations in patients prior to sodium altering therapy, and evaluate outcomes through evaluation of length of stay, discharge disposition, and modified rankin score (mrs).


Eligibility criteria:
inclusion criteria: * age ≥ 18 years of age * admitted to an intensive care unit for more than 48 hours * icd-9 codes for aneurysmal sah, tbi, iph, or intracranial tumor. exclusion criteria:

Keywords: sodium management neurointensive care hyponatremia