Kornimate/medical-research-clean huggingface dataset:
comprehensive versus traditional lifestyle program

Conditions: Obesity; Physical Fitness; Cognitive Function 1, Social

Summary: despite recommends that school-based interventions use a comprehensive approach for health promotions; most fitness programs exclusively emphasize physical activity. this study compared the comprehensive translational health in nutrition and kinesiology (think) program to a traditional ymca program (the sports, play, and active recreation for kids (spark) fitness curriculum) on measures of physical fitness, body composition, and executive cognitive function outcomes among 105 ethnic minority children (9±1.03 years old) following a 10-week intervention period.

despite recommendations that school-based interventions use a comprehensive approaches for health promotions; most fitness programs exclusively emphasize physical activity. this study compared the comprehensive translational health in nutrition and kinesiology (think) program to a traditional ymca program (the sports, play, and active recreation for kids (spark) fitness curriculum) on measures of physical fitness, body composition, and executive cognitive function outcomes among 105 predominantly, ethnic minority children (9±1.03 years old) following a 10week intervention period.

Eligibility criteria:
inclusion criteria: * to be eligible for this study, subjects had to be between the ages of eight and 12, enrolled in a ymca program, and able to participate in physical activity. parents were provided with information packets regarding project details, a parental consent form, and a child assent form. once the subjects assented and parents consented, a health questionnaire regarding child's age, gender, race/ethnicity, health history and ses was completed. exclusion criteria: * subjects with metabolic, cardiovascular, neuromuscular and psychological disorders and with medications that would interfere with testing results were excluded from the study.

Keywords: physical fitness body composition executive cognitive function
very low dose caudal morphine for postoperative pain management

Conditions: Caudal Anesthesia

Summary: this is a chart review. the aim of this study is to investigate the effectiveness and side effects of very low dose morphine administered caudally to children that went to surgical procedures that used caudal anesthesia. the study compares caudal block with bupivacaine (1 ml kg_1 of bupivacaine 0.25% and saline 0.02 ml kg_10) with very low dose morphine (a mix of 1 ml kg_-1 of ropivacaine 0.2% and preservative-free morphine: 10 µg kg-1).

caudal anesthesia is the most common technique of epidural anesthesia in children. caudal anesthesia is recommended for most surgical procedures of the lower part of the body, including herniorrhaphies; operations on the urinary tract, anus, and rectum; and orthopedic procedures on the pelvic girdle and lower extremities. many anesthetic agents have been used for caudal anesthesia in pediatric patients, with lidocaine and bupivacaine being most common. the major problems associated with this technique are the limited duration of analgesia and unwanted motor blockade. addition of medications that prolong analgesia after a single shot caudal block has been investigated. several authors have mentioned a special interest in using an opioid like morphine in caudal block for postoperative analgesia. when low dose morphine is used, the side effects are lower than when higher dose of morphine are used. a larger and definitive study is needed to compare very low dose morphine via caudal administration and caudal block without opioid with regard to duration of analgesia and frequency of side effects. we plan to conduct a chart review in our center on pediatric patients that went to urological, orthopedic, and general surgery procedures for which caudal block were given and compare the effectiveness and side effects of very low dose morphine and caudal block without opioid.

Eligibility criteria:
inclusion criteria: * the subject did have elective urological procedures such us circumcision, orchidopexy and inguinal hernia repair, orthopedic and general surgery procedures for which caudal block are usually administered for pain management. exclusion criteria: * subjects with non elective or emergency surgery (must have the surgery no matter what). * subjects with surgical procedures that are not planned to be conducted with the use of general anesthesia. subjects that are not allowed to receive the anesthesia agents indicated per protocol and general anesthesia. * american society of anesthesiologists, physical status classification greater than 2 (uncontrolled systemic disease or more than one systemic disease). * patients with a history of chronic pain conditions. * infection around the sacral hiatus. * coagulopathy. * anatomic abnormalities. * patient with mentally retardation. * patient with history of attention deficit and/or behavioral problems.
diagnostic imaging of lymph nodes in gynaecologic oncology

Conditions: Cervix Neoplasms; Ovarian Neoplasms; Endometrial Neoplasms; Vulvar Neoplasms; Lymphatic Metastasis

Summary: the purpose of the study is to determine the diagnostic accuracy of a new magnetic resonance imaging (mri) technique, the diffusion weighted imaging with body background signal suppression (dwibs) in the detection of lymph node pathology in patients with gynaecologic malignancies.

the presence of lymph node metastases indicates a poor prognosis, with a marked decrease in 5-year survival rate. lymph node involvement is an important factor in the choice of adjuvant treatment in gynaecological malignancies. surgical lymphadenectomy is the gold standard for the diagnosis of lymph node metastases. this is a highly specialized procedure with increase in operative time and cost, and risk of surgery-related morbidity. therefore, a non-invasive technique that accurately identifies lymph node metastasis would be beneficial. diffusion weighted whole body imaging with background signal suppression (dwibs) is a new imaging technique, which lightens lymph nodes and possibly differentiates normal and hyperplastic from metastatic lymph nodes. cancer metastases in lymph nodes may be associated with alterations in water diffusivity and microcirculation within the node. it is also likely that cell density might play an important role. so far, no feasibility studies have will be evaluated for its accuracy, effectiveness, and feasibility in detecting lymph node metastases in gynaecological malignancies, as a possible alternative for the surgical staging method. the accuracy of a pelvic lymph node dissection (reference test) will also be evaluated by performing a post-operative dwibs scan.

Eligibility criteria:
inclusion criteria: * patients with * cervical cancer stage ia2-ib, iia * endometrial cancer stage i (high risk), ii * ovarian cancer stage i, iia-iia * vulvar cancer stage i, ii * age \> 18 years * karnofsky score \> 70 exclusion criteria: * eligible for the portec ii trial * contra-indications to the mri: surgical clips in the brain, a pacemaker and claustrophobia

Keywords: gynaecological malignancy diagnostic accuracy dwibs lymph nodes metastasis
prevalence of nafld in acs patients

Conditions: NAFLD; ACS - Acute Coronary Syndrome

Summary: addressing cvd risk in patients with nafld is the aspect of the disease most amenable to medical management and so improving long-term clinical outcomes. almost no studies have been done concerning the prevalence of nafld in cvd patients, most of the conducted studies have been done in already diagnosed nafld patients to estimate the risk of cvd development. currently, there are no data available about the prevalence of nafld in cvd, more specifically patients with an acute cardiovascular event (ace) in belgium.


Eligibility criteria:
inclusion criteria: * \>18 years * having acute cardiovascular syndrome * able to understand dutch * able to understand the informed consent exclusion criteria: * excessive alcohol abuse * other liver disease * secondary causes of steatosis
establishing the reference interval for pulse oxygen saturation in neonates at high altitude

Conditions: High Altitude

Summary: the now widely used reference interval for pulse oxygen saturation of the neonate after 24 hours of birth has been developed relying on data from low altitude.it is not suitable for neonates at high altitude. at present, no reference interval has been established at high altitude, and the existing studies have many limitations. so this study was designed.

knowledge of the reference interval of pulse oxygen saturation (spo2) in neonates is crucial for accurate identification of neonatal hypoxemia. the now widely used standard was derived from low altitude data, which is not suitable neonates at high altitude. at present, many scholars have paid attention to this problem. but, previous studies still have some limitations. for example, they often only focus on a specific altitude. however, with the increase of altitude, the pulse oxygen saturation decreases in a curve, so their study results are only suitable for this specific altitude and can not be widely used.

Eligibility criteria:
inclusion criteria: * healthy singleton term infants with no clinical signs and symptoms (e.g., cyanosis, respiratory distress, heart murmur, etc.). exclusion criteria: * 1. low birth weight (\< 2500 g). 2. need for oxygen. 3.1 or 5 minute apgar score \< 7. 4. referred to the neonatal intensive care unit or neonatology department for various reasons. 5. neonates discharged within 24 hours of birth. 6. neonates diagnosed with congenital diseases in utero. 7. refusal of consent.
creatine-guanidinoacetic acid supplementation for sarcopenia (cregaas)

Conditions: Sarcopenia

Summary: sarcopenia-driven brain and muscle creatine deficit could be seen as a distinctive pathological facet of this condition, and this might be approached with targeted therapies in aim to restore creatine homeostasis in target tissues. among potential therapeutic candidates, guanidinoacetate (gaa) appears recently as a direct precursor of creatine that may favorably upregulate muscle and brain creatine concentration. interestingly, gaa-creatine mixture was found to be superior than creatine itself to effectively improves bioenergetics in the human brain and muscle in healthy humans, perhaps due to the unique transportability features of this combination. here, we plan to evaluate does creatine-gaa supplementation affects various biomarkers of sarcopenia in elderly.


Eligibility criteria:
inclusion criteria: * age \> 70 years * free of acute disorders exclusion criteria: * history of dietary supplement use during the past 4 weeks
effect of the amount of fluoride toothpaste on fluoride availability in the oral fluids in children

Conditions: Dental Caries

Summary: the aim of the study is to determine the fluoride availability in saliva and dental biofilm after the use of increasing amounts of fluoride toothpaste. using a crossover and blind design, 15 children (18-42 months old) had their teeth brushed with increasing amounts of fluoride toothpaste. fluoride concentration in saliva and dental biofilm was determined up to 30 min after brushing.

the aim of the study is to determine the fluoride availability in saliva and dental biofilm after the use of increasing amounts of fluoride toothpaste. children from 18 to 42 months from a community daycare participated. the study had a crossover and blind design. the amounts of toothpastes tested were: 1. a pea-size amount (0.3 g) of a non-f toothpaste; 2. 0.025 g of a f toothpaste (1,100 ppm f, as naf); 3. 0.05 g of the same f toothpaste; 4. 0.1 g of the same f toothpaste; or 5. 0.3 g (pea-size) of the same f toothpaste. children were to brush their teeth with the designated amount of toothpaste twice/day from monday to friday. in order to allow biofilm accumulation, caregivers were instructed to brush only the occlusal surfaces of primary molars. on friday morning, at least one hour after breakfast, saliva and one biofilm sample from the right or left hemiarch were collected and analyzed for fluoride concentration. then, brushing with the respective amount of toothpaste was performed, and saliva was collected 5, 15 and 30 min later. the biofilm from the other side of the mouth was collected after 30 min. fluoride concentration in saliva and biofilm samples was determined with an ion-specific electrode.

Eligibility criteria:
inclusion criteria: * all children with an informed consent signed by the parents/guardians exclusion criteria: * children with at least on active caries lesion

Keywords: dental caries fluoride toothpaste dentifrice
safety analysis of chronic intake of a β-alanine supplement

Conditions: Product Safety

Summary: single-center, double-blind, placebo-controlled clinical trial with two arms (product and placebo) to analyze the safety of beta-alanine consumption in active people.

after recruitment, subjects will be randomized and assigned to one of the two arms of the study: beta-alanine group or control group (placebo). subjects must be active people, and will take a dose of 15 g per day of the product for 4 weeks.

Eligibility criteria:
inclusion criteria: * men between 18 and 40 years of age. * physically active people. they must train at least 3 sessions per week. * have been training continuously for at least one year. exclusion criteria: * participant suffering from chronic illness. * serious or terminal illness. * suffering from a lasting injury that prevents him/her from training in the month prior to the intervention. * inability to understand the informed consent. * previous experience in the consumption of beta alanine.
the incidence of congenital undescended testis among dutch infants

Conditions: Undescended Testis

Summary: the purpose of this study is to determine the incidence of congenital undescended testis of mature boys, at one year of age, born in the medical centre alkmaar (mca).

the position of the testes of mature boys will be registered at birth and boys with a high-scrotal, non-scrotal or dubious position of the testis/ testes will be followed up (till the age of one year).

Eligibility criteria:
inclusion criteria: * mature newborns (\>/= 37 weeks) * born in the medical centre alkmaar exclusion criteria: * premature newborns (\< 37 weeks)

Keywords: congenital, high scrotal
environmental factors and thyroid cancer

Conditions: Thyroid Cancer

Summary: thyroid cancer incidence has been steadily increasing and has nearly tripled since the 1970's in the us and worldwide. early detection of small, papillary thyroid cancers using high quality diagnostic imaging explains only about 50% of this increased incidence, suggesting that there is a true increase in the occurrence of thyroid cancer and that changes in the prevalence of environmental risk factors might play a role in thyroid cancer etiology and progression. yet, the cascade of environmental triggers linked to thyroid cancer remains elusive. 'exposomics' studies all health relevant chemical exposures that an individual experiences, and leverages metabolomic platforms to estimate the "internal" environment, informing both exogenous exposures and the metabolic products that lead to, or arise from, disease. besides exposure to ionizing radiation as known modifiable risk factor, epidemiological evidence suggests that exposure to endocrine disrupting chemicals may be a potential thyroid cancer risk factor due to their known effects on thyroid function. however, these studies relied either on exposure questionnaires which are susceptible to recall bias, or used a limited set of targeted biomarkers measured after diagnosis for testing associations with case-control status, and not thyroid cancer prognosis. further, the molecular basis for observed associations with thyroid cancer remains unclear. to address the overall hypothesis that environmental exposures alter metabolic pathways and therefore affect thyroid cancer prognosis, small amounts of blood will be collected using dried blood microsampler technology (e.g. mitra® sampling devices), which is minimally invasive and can be used to collect repeated blood measurements at home, without the need for specialized training. these dried blood samples will be used to perform metabolomics experiments, which describe the sum of exogenous exposures, metabolic alterations, and biological response. additional exposure assessment will be performed using an exposure questionnaire. these results will be associated with thyroid cancer prognosis, e.g. disease-specific survival, disease recurrence, and mutational profiles, thus investigating the role of environmental exposures in the development of more aggressive forms of thyroid cancer.


Eligibility criteria:
inclusion criteria: * bethesda category iii, iv, v or vi following fine needle aspiration; if a patient has a benign tumor following surgery, patient data/ samples will be stored to serve as benign control in potential future projects. * age 18 years and older * surgical candidate * ability to provide informed consent exclusion criteria: * history of thyroid cancer * completion surgery candidate * pregnant women or other vulnerable patients (e.g. wards of the state, prisoners)
electronic device implantation through remote guidance

Conditions: Telemedicine; Heart Failure; Defibrillators

Summary: implantable cardioverter defibrillators (icd) and cardiac resynchronization therapy defibrillator (crt-d) implants are limited by availability and costs of field clinical specialist (fcs) bioengineers. this study explores feasibility of remotely supported implantations through an internet based platform, aiming at enhancing efficiency and overcoming geographical or pandemic related barriers. the first phase of the study included programming and phantom assessments in 20 cases followed by 10 remote guided crt-d and icd implantations in additional heart failure patients, compared to 20 procedures with fcs on site. data analysis revealed no significant differences in acute outcomes or electronic parameters at one year follow-up compared to on-site fcs. finally, this study demonstrates the safety after testing at one year of follow-up.


Eligibility criteria:
inclusion criteria: * patients over 18 years * patients under 85 years * patients already implanted with defibrillator and admitted to cardiology division for others invasive procedures * patients undergoing defibrillator or cardiac resynchronization therapy defibrillator implantation * patients who signed written informed consent exclusion criteria: * pacemaker dependent patients * patients who underwent generator replacement procedures

Keywords: electrophysiology remote monitoring technical support device
adapalene 0.3% - benzoyl peroxide 2.5% gel and risk of formation of atrophic acne scars

Conditions: Acne Vulgaris; Atrophic Acne Scars

Summary: this was a multi-centre, randomized, investigator blinded, vehicle controlled trial using intra-individual comparison (right half-face versus left half-face). participants with each half-face randomized to one of the two following treatments: * adapalene 0.3 percent (%) - benzoyl peroxide (bpo) 2.5% gel (tactupump® forte). * vehicle gel the main objective of this trial was to evaluate the effect of adapalene 0.3% - bpo 2.5% (abpo forte) gel versus vehicle gel on the risk of formation of atrophic acne scars in moderate to severe acne participants.


Eligibility criteria:
main inclusion criteria: * participants with clinical diagnosis of moderate to severe acne vulgaris on the face defined by: 1. investigator's global assessment score of 3 or 4, with same score on both sides; and 2. a minimum of 25 inflammatory lesions (papules and pustules) in total, with at least 10 on each side (excluding the nose); and 3. no more than two acne nodules (less than or equal to \[\>=\] 1 centimeter \[cm\]); and 4. a minimum of 10 atrophic acne scars in total (upper than 2 millimeters \[mm\]) (excluding the nose) * participants with a symmetric number of both inflammatory and non-inflammatory lesions on the whole face, and atrophic acne scars on the whole face. * participants with skin phototype of i to iv on fitzpatrick's scale. main exclusion criteria: * participants with acne conglobata, acne fulminans, secondary acne (chloracne, drug-induced acne, etc.), nodulo cystic acne, acne requiring systemic treatment. * prior failure to treatment with tactupump® forte (adapalene 0.3% - bpo 2.5%). * participants with more than 3 excoriated acne lesions. * participants with skin abraded on the treated area or affected by eczema, seborrhoeic dermatitis, cuts or sunburn. * female participant who is pregnant, nursing or planning a pregnancy during the trial or within one month after the last trial treatment application. * male participant with a beard or facial hair, which would interfere with the clinical trial evaluations or clinical trial procedures. * participants having received at least one of the following topical treatments on the treated area: corticosteroids, antibiotics, benzoyl peroxide, azelaic acid, hydroxyacids, zinc containing treatments, antibacterials, antiseptics, other anti-inflammatory drugs or other acne treatments (2 weeks); retinoids (4 weeks); cosmetic/aesthetic procedures on the face (1 week); photodynamic therapy, laser therapy, microdermabrasion for acne (3 months). * participants having received at least one of the following systemic treatments: corticosteroids (except locally acting corticosteroids such as inhaled or intrathecal or dermal application at distance from the face), antibiotics (except penicillin) (1 month); spironolactone (3 months) / drospirenone (3 months, unless dose is stable since at least 3 months); oral retinoids (6 months); cyproterone acetate / chlormadinone acetate (6 months); immunomodulators (3 months).

Keywords: acne scars
can we predict of the response of high risk non muscle invasive bladder cancer patients to intravesical bacillus calmette-guerin? the role of immunological markers

Conditions: Bladder Cancer

Summary: intravesical bcg is the mainstay adjuvant management of high risk nmibc. adequacy of immune system stimulation is the determinant factor for patient response to bcg. immunological markers for bcg-response could be helpful for urologists especially in the era of bcg shortage. objectives: to assess the predictive performance of different immunological markers on bcg-response in high risk nmibc bcg-naïve patients.

background: intravesical bcg is the mainstay adjuvant management of high risk nmibc. adequacy of immune system stimulation is the determinant factor for patient response to bcg. immunological markers for bcg-response could be helpful for urologists especially in the era of bcg shortage. objectives: to assess the predictive performance of different immunological markers on bcg-response in high risk nmibc bcg-naïve patients.

Eligibility criteria:
inclusion criteria: * patients with primary or recurrent nmibc for whom primary turbt was done. exclusion criteria: 1. patients with previous bcg instillation, 2. benign pathology 3. variant histology 4. non urothelial carcinoma, 5. concommitent upper tract urothelial tumors, detrusor muscle invasion 6. low or intermediate risk nmibc

Keywords: bladder cancer bacillus calmette-guérin response prediction urinary cytokines t cells recurrence progression