Kornimate/medical-research-clean huggingface dataset:
the safety and efficacy of 'avi' stent for treating coronary revascularization

Conditions: Ischemic Heart Disease; Myocardial Ischemia; Coronary Disease; Acute Coronary Syndrome

Summary: the study is a prospective, multi-center, single armed registry to evaluate the safety and efficacy of 'avi' stent for treating coronary revascularization.

the study is a prospective, multi-center, single armed registry to evaluate the safety and efficacy of 'avi' stent for treating coronary revascularization, 1200 primary coronary artery disease patients will be enrolled, at approximately 40 sites. subject follow-up will occur via telephone contact or clinical visit at 30 days, 6 months, 9 months, 12 months, 2-5 years after procedure.

Eligibility criteria:
inclusion criteria: patient must be at least 18 years of age; ischemic heart symptom and/or myocardial ischemia, include chronic stable/unstable coronary artery disease or acute coronary syndrome(st elevated mi and non-st elevated mi); at least one lesion with a diameter stenosis \>70% or more suitable for coronary stent implantation in a vessel with a reference diameter ranging from 2.5mm to 3.5mm; if the subject has multiple vessel lesions, the implanted stents must be the same brand. the staged procedure only be allowed within 3 months after procedure, the implanted stent must be the same brand stent as the index procedure; subject has no cabg contraindication; subject or legal representative is informed the property of the study, understand the stipulations in the protocol, ensure the compliance and sign the icf; exclusion criteria: pregnant or nursing patients and those who plan to become pregnant up to 1 year post index procedure; subject has a tendency to bleeding or coagulation disorders, or has contraindication of antiplatelet and/or anticoagulant therapy, or can't accept the continue dapt within 6 months; poor compliance or expectation of life less than 1 year; implanted any brand stent in the same target vessel within 1 year; left ventricular ejection fraction (lvef) of \<30%; cardiogenic shock or haemodynamics abnormal, needs inotropic agents or mechanical support; the subject is allergic to asprin, heparin, clopidogrel/ticlopidine, stainless steel alloy, arsenic trioxide, sirolimus, styrene-butene-styrene or polylactic acid(pla) polymer and contrast agent; severe tortuous and/or heavy calcification lesion; two or more proximal chronic total occlusion lesion; bifurcation lesions with double stents; the subject has multi-vessel lesions but can not be implanted the same brand stents; the subject that the investigator considers he/she was unfit to implant the avi stents and firebird 2 stents; the subject attended other drug/device study or in the follow-up period.
obstructive sleep apnea and non-alcoholic fatty liver disease

Conditions: Non-alcoholic Fatty Liver Disease; Sleep Apnea, Obstructive

Summary: obstructive sleep apnea (osa) and nonalcoholic fatty liver disease (nafld) are frequently encountered in patients with metabolic syndrome (ms). several data suggest that osa per se could be a risk factor of liver injury. most previous studies evaluating the association between osa severity and the severity of nafld used indirect markers of nafld including liver imaging or liver injury blood markers or have been performed in morbidly obese patients undergoing intraoperative needle liver biopsy during bariatric surgery. the current study propose to investigate with a full night polysomnography consecutive patients undergoing percutaneous liver biopsy for suspected nafld.


Eligibility criteria:
inclusion criteria: * suspected nafld requiring per-cutaneous liver biopsy exclusion criteria: * other than nafld liver disease * previously diagnosed or treated osa * excessive alcohol consumption (\>220 gr/week for men, \>140 gr/week for women) * pregnancy * surgical treatment for obesity past history
smart nutrition, healthier communities

Conditions: Obesity and Overweight

Summary: the project investigates the effect of the health app lifeness as a digital therapeutic (dtx) and follow-up tool in a municipal setting at a regional healthy lives center in central norway (frisklivssentralen værnesregionen), targeting early intervention for overweight and obesity.


Eligibility criteria:
inclusion criteria: * bmi ≤27kg/m2 or obesity measured by waist circumference, current weight stability, motivated to lifestyle change using mobile apps, access to smartphone with 5g. living in the municipallies covered by the værnes region of central norway. exclusion criteria: * previous bariatric surgery, use of anti-obesity drugs, pregnancy, current or present cancer diagnosis,substance abuse or psychiatric diagnosis (such as eating disorders), or other conditions that can hinder physical activity.
outcomes after parastomal hernia repair

Conditions: Parastomal Hernia

Summary: the aim of the current study is to evaluate the overall outcomes after parastomal hernia repairs in denmark from 2007-2017 using data from the danish hernia database and danish patients registry. specifically, the readmission and reoperation rates will be evaluated.

the danish hernia database covers about 80% of all ventral hernia repairs performed in denmark. data on size of hernia, type of surgery, type of mesh and fixation method is available from the danish hernia database. all healthcare services in denmark are registered in the danish national patients registry and data on 30-day readmission rate, readmission diagnosis and reoperation is found here. each danish citizen has a unique personal identification number and by merging data from the danish hernia database and national patients registry, nationwide data on parastomal hernia repairs is available. the aim of the current study is to evaluate the overall outcomes after parastomal hernia repairs in denmark from 2007-2017 focusing on readmission and reoperation rates.

Eligibility criteria:
inclusion criteria: * all patients undergoing parastomal hernia repair in denmark from 2007-2017 exclusion criteria: * if data is not fully registered in the danish hernia database
proton pump inhibitors in cirrhotic patients

Conditions: Proton Pump Inhibitor Adverse Reaction; Liver Cirrhosis

Summary: proton pump inhibitors (ppis) inappropriate use, in patients with cirrhosis, presents a significant clinical challenge. this study evaluates overprescription and misuse of ppis in cirrhotic patients. the patterns of use of ppis will be classified into two groups based on adherence to the proven indications: group a: inappropriate use of ppi, group b: appropriate use of ppi. we will estimate the prevalence of ppi misuse in cirrhotics and correlate it with different factors.

the inappropriate use of ppis in cirrhosis patients is a growing concern. evidence supporting the use of ppis in cirrhosis-related conditions is limited. several adverse outcomes have been linked to ppi use in cirrhosis, including an increased risk of spontaneous bacterial peritonitis and hepatic encephalopathy. the study aimed to assess the appropriateness of prescribing ppis to patients with cirrhosis, examining its impact on prescribing practices and identifying associated factors. in this observational, descriptive, cross-sectional study, cirrhotic patients receiving proton pump inhibitors will be included in the study. enrolled patients will classified according to the indication for ppi administration: group a: inappropriate use of ppi, group b: appropriate use of ppi. use of ppi will be considered inappropriate when prescribed without approved indication or used for a prolonged period beyond the recommended duration. the prevalence of ppi misuse in cirrhotics will be estimated and multivariate analyses will be conducted in order to identify independent predictors of inappropriate use of ppi.

Eligibility criteria:
inclusion criteria: * patients receiving proton pump inhibitors at the time of enrollment. exclusion criteria: * refusal to sign the informed consent form or failure to provide the required information

Keywords: proton pump inhibitors liver cirrhosis spontaneous bacterial peritonitis hepatic encephalopathy portal hypertension
echocardiographic manifestation in patients with omicron variant of covid-19

Conditions: COVID-19

Summary: the cardiovascular scenario associated with omicron, the new variant of severe acute respiratory syndrome-coronavirus-2 (sars-cov-2) that causes coronavirus disease 2019 (covid-19), remains unclear. we design this observational and prospective study to explore cardiac manifestations in patients with omicron infection by echocardiography.

covid-19 affects the cardiovascular system, and the presence of cardiovascular disease (cad) and risk factors is associated with worse clinical outcomes in infected patients. however, there is a paucity of information regarding the cardiovascular scenario associated with omicron, the new variant of sars-cov-2 that causes covid-19. thus, we expect to perform this study to explore the echocardiographic manifestations in patients admitted to the hospital with confirmed covid-19 infection, during the current omicron wave in shanghai, china. according to published guidelines, with written consent from eligible patients, participants are grouped into the severely ill group, the critically ill group, the mildly ill group, and the healthy control group. the investigators will review medical records and document detailed sociodemographic characteristics for each participant. circulating levels of cardiac biomarkers such as b-type natriuretic peptide (bnp) and cardiac troponin (ctni), inflammatory biomarkers such as interleukin 6 (il-6) and high-sensitivity c-reactive protein (hs-crp), and blood cell counts are measured in the hospital-based laboratory. to study the cardiac manifestations of the patients, echocardiography is performed using a ge vingmed ultrasound system (ge healthcare, horten, norway), and morphological and functional parameters of the heart are measured. clinical outcomes will be censored at the time of data cut-off, and patients after discharge will continue to be interviewed by telephone. differences in cardiac manifestations and clinical outcomes between the groups are compared by proper statistical tests.

Eligibility criteria:
inclusion criteria: * aged 18-75 years old * half male and half female * admitted to hospital with confirmed omicron infection * able to receive an echocardiographic examination * written informed consents * healthy volunteers, matched for age and gender, are enrolled as the control group exclusion criteria: * people under the age of 18 years old * inability to lie or maintain posture during the echocardiographic examination
iris-coroflex neo cohort

Conditions: Coronary Artery Stenosis; Coronary Artery Disease

Summary: the objective of this study is to evaluate the effectiveness and safety of coroflex isar neo stents in comparison to other drug-eluting stents (des) in real-world practice.


Eligibility criteria:
inclusion criteria: 1. patients ≥ 19 years old 2. patients receiving coroflex isar neo stents. 3. the patient or guardian agrees to the study protocol and the schedule of clinical follow-up, and provides informed, written consent, as approved by the appropriate institutional review board/ethics committee of the respective clinical site. exclusion criteria: 1. patients with a mixture of other dess 2. terminal illness with life expectancy \<1 year. 3. patients with cardiogenic shock

Keywords: percutaneous coronary intervention
prednisone for heart failure patients with hyperuricemia

Conditions: Heart Failure; Hyperuricemia

Summary: hyperuricemia is a very common finding in patients with heart failure. it is usually related to diuretic use and deteriorated renal function. the recently evidence showed that uric acid (ua) lowering therapy may improve clinical status in symptomatic heart failure patients with hyperuricemia. in their clinical practice, the investigators found that glucocorticoids could dramatically lower ua while improving renal function. thus the investigators design this randomized head to head study to test our hypothesis that prednisone have the same efficacy to allopurinol on lowering ua and could improve renal function at the same time.


Eligibility criteria:
inclusion criteria: * 18-70 years old * nyha class iii-iv * ef =\< 40% * uric acid =\> 9.5 mg/dl exclusion criteria: * acute gouty arthritis * any condition (other than chf) that could limit the use of prednisone or allopurinol * any concurrent disease likely to limit life expectancy. * active myocarditis, or an obstructive or restrictive cardiomyopathy * heart attack, stroke, unstable angina or cardiac surgery within previous 3 months

Keywords: prednisone allopurinol heart failure hyperuricemia
online self-compassion course for pals (compassion pals)

Conditions: Amyotrophic Lateral Sclerosis

Summary: this study is designed to be a pragmatic, single-arm trial to evaluate the efficacy, implementation, and feasibility of an online als-specific self-compassion training program to enhance self-compassion and improve quality of life.

optimizing quality of life for people with als is a primary goal of als multidisciplinary care, therefore, it is especially important to conduct research into interventions to address the psychological needs and well-being of people with als. recent studies have shown that mindfulness-based interventions promote improved quality of life for people with als. it is essential that such strategies as mindfulness-based interventions consider the specific needs of the als population and potential barriers to participation. very few studies have evaluated mindfulness-based interventions in the als population and no studies to date have evaluated self-compassion people with als. self-compassion has been linked to increased emotional resilience, psychological well-being, and quality of life in multiple populations. the intervention will include a 2-part workshop entitled 'introduction to mindful self-compassion for persons living with amyotrophic lateral sclerosis.' experience and feedback gained from the workshop will be incorporated into the format for an 8-week course in cultivating self-compassion for persons living with als (compassion pals). compassion pals will be adapted from the mindful self-compassion (msc) program to accommodate als clinical features and limit potential barriers to participation. the primary outcome will be quality of life assessed with the amyotrophic lateral sclerosis assessment questionnaire 5 (alsa-5). participants will be assessed at the 2-part workshop (t0, baseline), start of the 8 week compassion pals course (t1 = pre-intervention); after completing the intervention (t2, post-intervention). secondary outcomes will include secondary outcome measures the self-compassion scale short form (scs-sf), patient health questionnaire-9 (phq-9), general anxiety disorder-7 (gad-7), amyotrophic lateral sclerosis functional rating scale-r (alsfrs-r), feasibility of intervention measure (fim), acceptability of intervention measure (aim), and intervention appropriateness measure (iam).

Eligibility criteria:
inclusion criteria: * diagnosis of als within the last 18 months. * 18 years or older * access to and the physical ability to use a computer with internet access with and/or without adaptive devices. * ability to communicate and understand tasks. * a caregiver available to provide assistance. * ability to provide informed consent exclusion criteria: * more than one neuropsychological impairment such as (frontotemporal dementia) which may interfere with the study procedures. * severe medical condition that would reduce life expectancy to less than 6-12 months. * no access to a computer with internet access * unsuitable for the study as determined by the investigator.
retrospective review of ct and mr in pediatric patients with cholestasis

Conditions: Cholestasis; Children

Summary: the investigators will try to predict the risk of esophageal varices (evs) in long-term ba survivors using noninvasive computed tomography (ct) or magnetic resonance (mr) indices and the measurement of transverse diameters of paraesophageal and gastroesophageal veins.

we intend to review retrospectively 80 pediatric patients on an average of 2 years, who underwent 64-slice ct or mr examinations between january 2005 and oct 2010 and had evs on esophagogastroduodenoscopy. splenic diameters (mm) and hepatic diameters of all patients were measured. splenic and hepatic volume indices also calculated. the transverse diameters of paraesophageal varices (pvs) and perigastric varices (pgvs) were measured adjacent to the lower thoracic esophagus and within the lesser sac, respectively. we will try to find out the possible splenic, hepatic or vascular predicting factors useful to evaluate the risk of clinically evident esophageal varices.

Eligibility criteria:
inclusion criteria: * all cholestatic children with ct, mr and complete medical record exclusion criteria: * all cholestatic children without either ct, mr or complete medical record

Keywords: cholestasis children
randomized controlled trial of tcrfvr and laup in snorers

Conditions: Snorer

Summary: we hypothesis that radiofrequency will cause less post-operative discomfort when compared with laser assited uvulopharyngoplasty. 40 patients with primary snore will be enrolled into this study. after overnight sleep test confimred that no obstructive sleep apnea existed, cases were informed consented. then they were randomized into two groups. post-operative pain, duration of analgesics were recorded.

although rf group was less effective, they felt less discomfort.

Eligibility criteria:
inclusion criteria: * rdi \< 5/h exclusion criteria: * previous treated snoring, coagulation disorder

Keywords: tcrfvr, laup, snorer
alternatives for reducing tics in tourette syndrome (ts): a study of tev-50717 (deutetrabenazine) for the treatment of tourette syndrome in children and adolescents

Conditions: Tourette Syndrome

Summary: this is a study to evaluate the efficacy and safety of deutetrabenazine (tev-50717) tablets for the reduction of motor and phonic tics associated with ts in children and adolescents 6 through 16 years of age.


Eligibility criteria:
inclusion criteria: * participant is 6 to 16 years of age, inclusive. * participant weighs at least 44 pounds (20 kilograms \[kg\]). * the participant's active tics are causing distress or impairment. * participant is able to swallow study medication whole. * participant is in good general health. * women/girls of childbearing potential whose male partners are of childbearing potential must use contraception for the duration of the study. * additional criteria apply, please contact the investigator for more information exclusion criteria: * participant has a neurologic disorder other than ts that could obscure the evaluation of tics. * participant has a confirmed diagnosis of bipolar disorder, schizophrenia, or another psychotic disorder. * participant has clinically significant depression at screening or baseline. * participant has a history of suicidal intent or related behaviors within 2 years of screening. * participant has a history of a previous actual, interrupted, or aborted suicide attempt. * participant has a first-degree relative who has completed suicide. * participant has received comprehensive behavioral intervention for tics (cbit) for ts or cognitive behavioral therapy (cbt) for obsessive-compulsive disorder (ocd) within 4 weeks of screening. * participant has an unstable or serious medical illness at screening or baseline. * participant is pregnant or breastfeeding. * additional criteria apply, please contact the investigator for more information.

Keywords: tourette syndrome adolescents children
effect of yoga-based exercises of healthcare workers during covid-19 pandemic: prospective clinical trial

Conditions: COVID-19 Pandemic; Yoga; Exercise Therapy; Mind-Body Therapies; Muscle Stretching Exercises

Summary: to investigate the effect of yoga-based exercises therapy on functional capacity, dyspnea, quality of life, depression, anxiety, and sleep quality in healthcare professionals following covid-19.

twenty-six healthcare professionals who were diagnosed with covid-19, whose treatments were completed, and who were actively working during the subacute period with ongoing complaints were included in the study. the exercises program consisting of stretching, relaxation, isometric strengthening, breathing, and meditation exercises were given to the healthcare professionals under a 60-minute yoga-based exercises program held twice a week for a period of eight weeks. flexibility and muscle strength measurements of the patients were calculated by the sit and reach test, shoulder flexibility test, and a hand dynamometer. functional capacity was evaluated with the 6-minute walk test (6mwt), physical activity and dyspnea severity with the modified medical research council (mmrc) dyspnea scale, depression and anxiety level with the beck depression and anxiety inventory, the quality of life with the sf-36, and sleep quality with the pittsburgh sleep quality index (psqi).

Eligibility criteria:
inclusion criteria:prospective clinical trial patients who were covid-19 pcr (+) and/or diagnosed with covid-19 pneumonia by computed tomography, completed their medical treatment, had ongoing fatigue, dyspnea, decreased stamina, difficulty in activities of daily living, anxiety, and depression complaints, had an event duration of 2 to 6 months, were actively working (between 25-60 years of age), and had a stable general condition and cognitive ability were included in our study. exclusion criteria:patients who were hemodynamically unstable, whose cardiac and pulmonary system stability could not be maintained, who had rheumatic, neurological, and psychological disorders, and those who could not continue the program due to working conditions were determined as exclusion criteria.

Keywords: yoga covid-19 quality of life healthcare workers sleep quality
womens's experiences of pregnancy loss aftercare in the gynecological emergency

Conditions: Miscarriage

Summary: introduction: scientific papers on the womens's experiences of pregnancy loss aftercare in the emergency department show that how announcement is made and how much caregivers show empathy to women, help women to face this difficult moment. however, in most studies, women say they did not have enough information nor support from the medical teams. diagnosis of miscarriage in the emergency department is the routine for the caregiver but is often experienced by the woman as the loss of a child. this study has for goal to bring to light the discrepancy between the caregivers's experience and the women's experience :the given information, the time for consultation, the empathy. methods : 2 months after the diagnosis of miscarriage in the emergency room, patients receive a phone call with explanations about the project. if the patient gives her consent, she receives a computer questionnaire by email (questions about : reasons for coming to the emergency room, circumstances of announcement, information given in the emergency room, satisfaction with the care...) in parallel, caregivers have to complete a questionnaire about the same parameters. the main objective of this study is to evaluate womens's experiences of pregnancy loss aftercare in the emergency department of montpellier hospital. the second objective is to assess the discrepancy between the patient's experience and the caregivers' experience in this situation with the aim of suggesting improvement.


Eligibility criteria:
inclusion criteria : an individual must fulfill all of the following criteria in order to be eligible for study enrollment: * women \> 18 years old * french speaker * diagnosis and management of miscarriage / pregnancy loss in the emergency department * miscarriage / pregnancy loss \< 15 sa exclusion criteria: * subject unable to read or/and write * pregnancy loss \> 15 sa.