xenazine in late dyskinetic syndrome with neuroleptics

Conditions: Tardive Dyskinesia

Summary: late dyskinetic syndrome with neuroleptics, or tardive dyskinesia, is the appearance of abnormal involuntary movements (aim) in patients treated with antipsychotics for at least three months. this important public health issue arises for 15-20% of patients treated with neuroleptics, the most prescribed psychotropic drugs in mental disorders in france, and seriously impacts the patients' quality of life. in over 50% of cases, it is irreversible-that is to say that he will persist despite discontinuation of the offending drug. risk factors have been described: the age and female gender are established, a higher dosage of antipsychotic, a long-term treatment, a psychiatric condition other than schizophrenia are likely risk factors, intermittent treatment, previous acute dyskinesia, neuroleptics or powerful, longer term use of corrective treatments including anticholinergics are still discussed. apart from preventive treatment, which consists in using antipsychotics as being coerced, support is disappointing: the etiological treatment, which is to stop the offending antipsychotic, is effective only in less than 50% of cases, the syndrome is most often late irreversible. must still have the possibility to interrupt the treatment, which is usually impossible in the risk of decompensation of the mental illness for which the neuroleptic was prescribed. remains symptomatic treatment: functional neurosurgery is only for extreme cases, because it is not without risk, in terms of morbidity and mortality. so it's the medication that is most often offered: many drugs have been proposed, a direct result of the multiplicity of neurotransmitter systems implicated. however, in the vast majority of cases, this approach is disappointing not to say ineffective. the only exception is the tetrabenazine, marketed under the name of xenazine®. empirically, neurologists specializing in pathology of the movement are almost unanimous: its efficiency is very good, with good tolerance. some preliminary studies have reinforced this impression. however, their level of evidence remains low and that is why the investigators propose to implement a prospective multicenter clinical trial, double-blind with placebo which will include two groups of 27 patients.

tetrabenazine is classified as a central monoamine depleting agent. in vitro studies have shown that it is an inhibitor of the vesicular monamine transporter 2 (vmat2), resulting in synaptic dopamine depletion. this effect explains the reduction of hyperkinetic movement disorders. although tetrabenazine enjoys a reputation of very good efficacy in tardive syndromes, with good tolerance, it is still yet to empiricism because studies are few andf most importantly, of low level of evidence according the criteria of evidence based medicine. this is a randomized, multicenter, parallel group, double-blind placebo (tetrabenazine/placebo: 1/1), in two comparative conditions before and after 10 weeks of treatment with tetrabenazine (5-week titration to a maximum dose of 200 mg/day and 5 weeks at stable dose). study enrollment is proposed to patients fulfilling inclusion criteria. the study should process as follows: 1. patients give their informed consent for participation after presentation of the study by the investigator. 2. visit v0: given the patient's signed consent, global clinical examination, blood sampling, vital signs (weight, height, arterial tension, ecg are performed as well as a neurological examination (mms). for women in childbearing potential, a urinary pregnancy test will be realized. it is noteworthy that a psychiatric consultation dating less than one month is required. 3. visit v1: patient is randomized in one of the two arms: tetrabenazine or placebo. some tests are performed at baseline: * neurologic: esrs, aims, cgi, updrsiii, mms; * quality of life auto-questionnaires: sf36, epworth; the treatment is prescribed following a titration phase during 5 weeks, a stable dose during 5 weeks, and a wash-out period during 2 weeks. 4. at v2 (1 week after v1), v3 (3 weeks after v1) and v5 (7 weeks after v1): global clinical examination is performed and prescription observance is checked. 5. at v4 (5 weeks after v1), v6 (10 weeks after v1) and v7 (12 weeks after v1): neurological (esrs, aims, cgi, updrsiii, auto questionnaire sf36, epworth, neuropsychological examination (madrs), psychiatric examination (only at v6), vital signs and prescription observance.

Eligibility criteria:
inclusion criteria: 1. adult (age over 18) or adult under judicial protection (tutor or curator). 2. patient with late dyskinetic syndrome with neuroleptics yielding functional disability and/or impact in every day's life, according to the investigator, and/or the patient and/or the patient's family. 3. patient with persistent late dyskinetic syndrome, even if the neuroleptic has been stopped for more than 6 months or patient with late dyskinetic syndrome under neuroleptic treatment unchanged for at least 3 months and which would a priori not need any dose variation during the study time. 4. madrs \< 18 5. qtc \< 450 ms for men and \< 470 for women. exclusion criteria: 1. lack of social insurance 2. neuroleptic treatment less than 3 months 3. insanity according to the dsm iv and mms \< 24 4. predominant akathisia 5. psychiatric disease not stabilized for more than 6 months and/or which could require a neuroleptic treatment adaptation during study time. 6. pregnancy and lactating 7. women in genital activity without efficient contraception method (iud or estrogen-progestin pill) 8. hypersensitivity to tetrabenazine 9. renal failure 10. drugs: non-selective maois, dopaminergic (or other antiparkinsonian) 11. other severe pathology 12. patient non compliant to protocol, at the investigator's appreciation 13. simultaneous participation to other clinical trial 14. congenital galactosemia, glucose malabsorption or lactase deficiency

Keywords: tetrabenazine movement disorders tardive disorders