Kornimate/medical-research-clean huggingface dataset:
traumatic characteristics of the forensic cases admitted to emergency department and errors in the forensic reports

Conditions: Emergencies; Trauma

Summary: objectives: to detect the mistakes and deficiencies of the forensic reports which was written and to detect the injury characteristics of the forensic cases applied to emergency service of a tertiary hospital.

all patients who applied for reasons such as crushing, traffic accidents, firearms and explosive injuries, assault, all kinds of injuries, burns, electric shock, asphyxia, torture, child abuse, falls and other injuries, poisoning and suicide attempt are a forensic case.traumatic forensic cases are often confronted in emergency departments, aim to this study is to detect the mistakes and deficiencies of the forensic reports which was written and also aimed to detect the injury characteristics of the forensic cases applied to emergency department which is the most important center in region at a tertiary hospital.

Eligibility criteria:
inclusion criteria: * traumatic forensic cases which written a forensic report were included in study. exclusion criteria: * the forensic cases which can not be reached the forensic report and patients' emergency department chart
effect of lipid modifying drugs on hdl function in patients with hyperlipidemia

Conditions: Hyperlipidemia

Summary: 1) to test hdl function comprehensively in healthy and diseased individuals; 2) to evaluate if this test correlates with cardiovascular risk, independent of traditional risk factors; 3) and to differentiate effects of lipid-modifying or antiatherosclerotic drugs on hdl function and composition


Eligibility criteria:
inclusion criteria: * the patients who meet the 2013 american college of cardiology/american heart association criteria for receiving lipid-lowering therapy * aged over 20 * consent form signed exclusion criteria: * pregnant or lactating women * subjects with familial hypercholesterolemia * uncontrolled hypertension or dm * thyroid dysfunction * active liver disease (transaminase or bilirubin \> 1.5 x nl) * serum creatinine \> 2 mg/dl * included in other clinical trials within 3 months * using of other medication: fish oil, fibric acid derivatives, niacin, systemic corticosteroid, thiazolidinedione
biomechanical and viscoelastic properties of plantar fascia in diabetes mellitus

Conditions: Diabetes Mellitus

Summary: in this study, an attempt has been made to analyze the changes in soft tissue biomechanical properties of plantar surface in diabetes. the second aim of this study was to explore the relationships between fear of falling, physical performance, and plantar stiffness in patients with diabetes.

chronic diabetes can lead to ulceration in the plantar region and may result in amputation. diabetes-related foot ulcerations are one of the most challenging complications of diabetes mellitus. myotonometry, a technique to measure dynamic stiffness is preferred due to its noninvasiveness, easy employability, and rapid investigation. in this study, an attempt has been made to analyze the changes in soft tissue biomechanical properties of the plantar surface in diabetes. increased plantar tissue stiffness is thought to alter the distribution of tensile stresses in the plantar soft tissues during gait. combined with a reduction in plantar tissue thickness, these changes could collectively decrease the mechanical loads required to initiate soft tissue breakdown and thus lead to foot ulceration formation. diabetes mellitus is a significant risk factor for falls in adults and is associated with an increase in fear of falling. microvascular complications associated with dm result in multiple impairments including sensory deficits and muscle weakness due to peripheral neuropathy, loss of visual acuity due to retinopathy, and impaired postural control and falls due to vestibulopathy. the prevalence of falls and fear of falling are significantly higher in adults with diabetes mellitus. assessment of mechanical properties of plantar tissues can aid in the early diagnosis of ulceration. in this study, an attempt has been made to analyze the changes in soft tissue biomechanical properties of the plantar surface in diabetes. the second aim of this study was to explore the relationships between fear of falling, physical performance, and plantar stiffness in patients with diabetes.

Eligibility criteria:
inclusion criteria: * diagnosed with diabetes mellitus for more than three years * individuals without a history of diabetes mellitus affirmed by a normal range of fasting blood sugar and hemoglobin a1c levels. * age≥18 years exclusion criteria: * history of central nervous system conditions * no visual and vestibular impairments * amputation of the lower limb * history of fracture * surgery of lumbar and lower limb * having pain resulting in movement difficulty

Keywords: plantar fascia stiffness diabetes mellitus fear
effectiveness of nutrition education in carbohydrate counting in people with type 1 diabetic

Conditions: Type 1 Diabetes

Summary: carbohydrates are the nutrient in the diet with the greatest impact on blood glucose. inadequate carbohydrate counts are associated with higher a1c and greater variations in postprandial blood glucose. clinical guidelines for the nutritional treatment of diabetes recommend that patients with dm1 learn carbohydrate counting or some similar systematic strategy that allows for better metabolic control. however, despite the recommendations, this is still not a reality for most healthcare services treating individuals diagnosed with dm1.

the study aims to assess the impact of a structured nutrition education programme for nutritional education and carbohydrate counting, in group sessions, on glycemic control and nutritional literacy in people with dm1. this will be achieved by evaluating the glycaemic control through a1c and daily glycaemic variability (time on target, mean glycaemia), as well as the level of knowledge before and after the intervention.

Eligibility criteria:
inclusion criteria: * adults aged ≥18 years old who have been diagnosed with type 1 diabetes or parents of children and adolescents (\< 18 years old) who have been diagnosed with type 1 diabetes; * to be under intensive insulin therapy (basal/bolus system); * to regularly use a continuous glucose monitoring system as primary method for glycaemic control; * to be able to read and write. exclusion criteria: * none
human amniotic membrane plug for large macular holes

Conditions: Macular Holes

Summary: this is a prospective, interventional, consecutive case series conducted in alexandria university. the aim of the study is to evaluate the therapeutic efficacy of human amniotic membrane in promoting closure of large macular holes.

this is a prospective, interventional, consecutive case series conducted in alexandria university. the aim of the study is to evaluate the therapeutic efficacy of human amniotic membrane in promoting closure of large macular holes. included participants with large macular holes will undergo complete vitrectomy is performed with an accurate vitreal base shaving (constellation; alcon surgical). a human amniotic membrane ham plug is taken from the ham patch, and the final dimensions are adjusted with vitreoretinal scissors before insertion into the vitreous. the ham plug is rolled inside the vitreoretinal forceps and inserted through the trocar into the vitreous. then the human amniotic membrane is transplanted through macular hole into the subretinal space; it is then spread to cover the entire portion of the hole. afterward, perfluorocarbon is injected to a complete overfilling of the break to permit good adhesion of the ham plug to the underlying rpe and the overlying retina. fluid-air exchange and an endotamponade injection is performed at the end of surgery.

Eligibility criteria:
inclusion criteria: * large macular hole confirmed by optical coherence tomography exclusion criteria: * patients who had diabetic retinopathy, vascular occlusion, retinal neovascularization, inflammatory disease and optic atrophy

Keywords: human amniotic membrane; large macular holes
a multicenter, randomized, double blind, double dummy, parallel-group efficacy study comparing 8 weeks of treatment with esomeprazole magnesium (40mg qd) to lansoprazole (30mg qd) for the healing of erosive esophagitis in patients with moderate or severe erosive esophagitis

Conditions: Erosive Esophagitis

Summary: this study looks at the healing rates in patients with erosive esophagitis (ee) when treated with either esomeprazole or lansoprazole


Eligibility criteria:
inclusion criteria: * episodes of heartburn (described as a burning feeling, rising from the stomach or lower part of the chest up towards the neck) for 2 days or more during the last 7 days prior to baseline. * confirmed erosive esophagitis within 1 week prior to starting the study. exclusion criteria: * any signs of gastrointestinal bleeding at the time of the starting the study. * any previous gastric or esophageal surgery. * various gastrointestinal diseases as listed in the protocol.

Keywords: erosive esophagitis nexium heartburn
geriatric assessments in elderly diffuse large b-cell lymphoma patients-2 (geriad2)

Conditions: Lymphoma, Large B-cell, Diffuse

Summary: this study will validate the impact of comprehensive geriatric assessments using activity of daily living (adl), instrumental activity of daily living (iadl), and charlson's comorbidity index (cci) on survival and toxicities in korean patients with diffuse large b-cell lymphoma (dlbcl) treated with r-chop.


Eligibility criteria:
inclusion criteria: * patients with newly diagnosed cd20+ dlbcl * 65 years old or over * scheduled to receive r-chop chemotherapy * informed consent exclusion criteria: * other histology than cd20+ dlbcl * primary central nervous system dlbcl * patients with a diagnosis of cancer (other than basal or squamous cell carcinoma of the skin, cervical carcinoma in situ, well differentiated thyroid cancer \[papillary or follicular thyroid cancer\]) within 3 years before the study entry or with any treatment for cancer within 3 years before entry * consent withdrawal

Keywords: geriatric assessments diffuse large b-cell lymphoma activity of daily living instrumental activity of daily living charlson's comorbidity index
role of dietary fatty acids in fatty liver and insulin resistance

Conditions: Obesity; Diabetes; Insulin Resistance; Fatty Liver

Summary: the purpose of this study is to investigate whether substituting saturated fats with polyunsaturated fats reduces fatty liver and improves insulin action and other metabolic variables in abdominally obese subjects

specific goals: 1. investigate if substituting saturated fats with polyunsaturated fats reduces steatosis and improves hepatic and/or peripheral insulin action in abdominally obese subjects with type 2 diabetes 2. investigate if changes of lipogenic enzymes in response to dietary fat intervention are associated with changes in hepatic/peripheral insulin sensitivity or liver fat content 3. investigate potential mechanism of the effects of dietary fatty acids; e.g. gene expression and lipogenic enzyme activity

Eligibility criteria:
inclusion criteria: * abdominal obese subjects with or without type 2 diabetes * sagittal abdominal diameter \>25cm exclusion criteria: * insulin treatment * history of serious cardiovascular events * morbid obesity * claustrophobia (relative criterion)

Keywords: obesity diabetes insulin resistance fatty liver nafld steatosis dietary fatty acids
a pilot study to characterize the household impact of locating devices for children with asd who wander

Conditions: Autism Spectrum Disorder; Wandering Behavior

Summary: this pilot study will obtain preliminary data about the impact of wearable electronic tracking devices (etds) as an intervention for children with autism spectrum disorders (asd) who wander. the feasibility of all study procedures and the acceptability of the intervention will be evaluated.

wandering, or elopement, is a life-threatening behavior that has been reported to occur in a third of all children with autism spectrum disorders (asd). wearable electronic tracking devices (etds) that are able to pinpoint a child's location have emerged as an appealing intervention for families concerned about wandering risk. however, the impact of etd use on the families of children who wander has never been studied prospectively. in this pilot study, parents will be provided with a commercially-available etd to use for their child with asd for 6 weeks. preliminary data will be obtained to evaluate the impact of etd use on the strain experienced by families due to their child's wandering behavior. the feasibility of all study procedures will be assessed in preparation for a larger subsequent trial.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * parent of a child between the ages of 4 and 17 who currently has autism spectrum disorder (asd), was diagnosed with asd by a professional, and has wandered at least once in the preceding 3 months * currently lives in the united states * currently lives with child with asd * has been living with child with asd for at least 6 months * has reliable internet access to allow for completion of online questionnaires exclusion criteria: current or past use of any electronic tracking device to address wandering behavior in the child with asd
prepare - preoperative anxiety reduction

Conditions: Anxiety Disorder; Surgery

Summary: the study aims to verify if a short individual psychological intervention might increase perceived self-efficacy in managing preoperative anxiety in patients who will undergo pancreatic surgery. it is a randomized clinical trial where half of participants will attend a psychological intervention based on "the four elements protocol" by elan shapiro the day before surgery, while the other half will follow usual care.

patients who have to undergo surgery experience multiple sources of stress. a recent narrative review carried out on 115 studies by powell et al. (2016) reported different and inconsistent findings on the relation between psychological interventions and surgery outcomes, due to the heterogeneity of these interventions, mainly based on information giving and patient education, and the very different samples of patients considered. some evidences showed that pre-operative psychological interventions may contribute to reduce post-operative pain, duration of hospital stay (mean difference of 0.52 days) and negative affect. no studies were conducted with patients who had to undergo pancreatic surgery nor specific psychological interventions were devoted to increase self-efficacy in managing anxiety. the aim of the present study is to verify if a short individual psychological intervention devoted to improve patient's ability to manage anxiety could increase his/her confidence to cope with pancreatic surgery, either in terms of perceived self-efficacy (main outcome) or less state anxiety reported on stai-y1 scale. post-surgery outcomes are also collected: pain reported during the days following surgical intervention, length of hospital stay and number and type of clinical complications. the study will involve 400 patients randomly divided in two arms and it is organized in four phases: t0,t1,t2,t3. t0: once obtained the informed consent, demographic information will be collected using a structured questionnaire. clinical variables will be collected by self-administered tools, for which patients can ask support, if needed. t1: the day before surgery, all patients will indicate their perceived self-efficacy in managing anxiety and will fulfil specific anxiety scales. t2: after randomization, patients in the experimental group will participate to the psychological intervention, whereas the control group will follow usual care. t3: after surgery pain, length of hospital stay and the number of post-operative complications within 30 days will be evaluated as secondary outcomes on all patients.

Eligibility criteria:
inclusion criteria: * 18 - 80 years old * cognitively able to give personal consent to participate to the study * to be scheduled to have general anaesthesia for pancreatic surgery exclusion criteria: * age under 18 years and over 80 years * cognitively unable to give personal consent to participate to the study * postponement of surgical operation

Keywords: preoperative anxiety self-efficacy psychophysiology psychotherapy pancreatic surgery
increased inflammation-resolving activity by omega-3 monoglycerides in peripheral blood mononuclear cells (pbmc).

Conditions: Resolution of Inflammation; Reduction of Cell Proliferation

Summary: the purpose of this biological study is to provide dr. samuel fortin's laboratory with a continuous supply of blood mononuclear cells (pbmcs) so that he can pursue research on the potential beneficial effects of monoglyceride omega-3 fatty acids on the resolution of inflammation.

the biological activity of omega-3 fatty acids requires selective oxidation by lipoxygenase (lox) enzymes in the human body to form spm (specialized pro-resolving mediators). the formulations based on omega-3 monoglyceride (mag-omega-3) currently marketed by scf pharma have been optimized so as not to interfere with this natural metabolism process in the human body. it has already been shown that the antiproliferative activity of docosapentaenoic acid (or omega-3 adp) can be increased tenfold when it is pre-metabolized using a lox enzyme from soybean (c. morin et al. plefa (2013) 203-213). this antiproliferative potential may play a key role in the mechanisms of inflammation resolution. we now want to develop a new line of high performance products by pre-metabolizing mag-omega-3 in the form of spm monoglycerides (mag-spm) using the lox enzyme from soy. the potential for resolving inflammation by mag-spm can be measured by cell proliferation assays. to perform these tests, cells of the pbmc type must be isolated from the blood of donors and maintained in culture in the presence of an inflammatory agent (lps) which induces their proliferation (c. morin et al. european journal of pharmacology 807 (2017)) 205-211). next, the reduction in proliferation induced by mag-spm is quantified and then compared with that of cells not treated with mag-spm. this type of test requires a large amount of fresh cells, and therefore, a source of blood sample supply. this research project is divided into two parts: 1) a protocol for collecting blood samples; 2) a cell proliferation test protocol to demonstrate the activity of mag-spm in the resolution of inflammation. this protocol covers the first part of this research project.

Eligibility criteria:
inclusion criteria: * participant aged of at least 18 years old. exclusion criteria: * participant who use omega-3 supplements and / or anti-inflammatory medication such as, but not limited to - aspirin, ibuprofen (motrin, advil), celecoxib (celebrex), diclofenac (cambia, cataflam, voltaren ) within 7 days of day 1 of the study.
a study of a new asthma medicine in asthmatics whose asthma worsens with exercise

Conditions: Asthma

Summary: the primary objective of this study is to demonstrate that the combination of inhaled fluticasone furoate/vilanterol (100 mcg/25 mcg) once daily provides superior protection throughout the day against bronchoconstriction induced by exercise compared with fluticasone propionate 250 mcg twice daily in adolescent and adult subjects aged 12 to 50 diagnosed with persistent asthma.


Eligibility criteria:
inclusion criteria: * outpatient male or female 12 to 50 years of age * females of child-bearing potential must be willing to use birth control or commit to abstinence during the study * diagnosis of persistent asthma for at least 6 months * best pre-bronchodilator fev1 of at least 70%. * current use of a low- to moderate-dose inhaled corticosteroid * ability to withhold albuterol 6 hours prior to visits. * physically able to perform exercise testing on a treadmill when albuterol has been withheld exclusion criteria: * intermittent asthma, seasonal asthma, or exercise-induced asthma only * symptomatic allergic rhinitis and/or thrush * abnormal, clinically significant electrocardigraph * respiratory infection within 4 weeks of first visit leading to asthma medication change or could affect subjects's asthma status or participation * asthma exacerbation within 12 weeks of first visit * respiratory diseases or other concurrent disease that would put subject at risk or confound results interpretation * investigational medicines within 30 days of first visit or less than five half-lives of medication in prior study * allergy to study drugs or study drug excipients * concomitant medications that could interact with study medications or affect the course of asthma * tobacco use within last year and/or a 10 pack-years history * inability to comply with requirements of the study * affiliation with investigator's site (example: family member)

Keywords: exercise-induced bronchospasm activity/exercise induced bronchospasm asthma
performance characteristics and technical outcomes of single-use gastroscopes used bedside versus reusable gastroscopes used in the endoscopy unit evaluated in subacute patients

Conditions: Upper Gastrointestinal Disorder

Summary: the aim of this study is to investigate whether single-use gastroscopes used bedside can reduce the time from indication to procedure compared with re-usable gastroscopes used at the endoscopy unit in patients referred to a subacute gastroscopy. participants in the first period will be scheduled for gastroscopy with a re-usable gastroscope in the endoscopy unit, whereas participants during the second period will have a gastroscopy performed at the ward (bed-side) with a single-use gastroscope.


Eligibility criteria:
inclusion criteria: * patients of any gender, 18 years of age or older admitted to the acute section of the surgical department (kir2) at zealand university hospital referred to early egd without general anesthesia. exclusion criteria: * asa-score of 4 or higher * unstable patient * suspicion of ventricular retention * suspicion of active bleeders * need for expert endoscopist to perform the procedure, e.g. stenting * patients \< 18 years of age

Keywords: gastroscopy upper endoscopy gastroscope single-use reusable bedside