Kornimate/medical-research-clean huggingface dataset:
ataglu: study of glucose metabolism in hiv positive patients that switch from another protease inhibitor to atazanavir

Conditions: HIV

Summary: the association between hiv infection , insulin resistance and diabetes mellitus is the topic of many studies that have attempted to analyze the problem from different points of view. in fact, the risk of insulin resistance in hiv-positive patients on antiretroviral therapy seems to depend not only on the same factors that determine its incidence in the general population , but also on the effects of antiretroviral therapy on glucose metabolism. to confirm this observation, studies that have evaluated the incidence of diabetes in patients with hiv infection on antiretroviral therapy have shown that the incidence of diabetes in infected individuals is significantly higher than that observed in the uninfected population. moreover others preliminar stadies observed that protease inhibitors may induce hyperglycemia and diabetes mellitus. anyway at this moment no large data are available that indicate the utility to modify the antiretroviral therapy in hiv positive patients with a damage of glucose metabolism. ataglu is a cohort composed by hiv positive patients in effective and stable combined antiretroviral therapy (cart) with undetectable viral load. all patients studied had carried out a therapy with lopinavir/ritonavir (lpv/r) + optimal backbone therapy (obt) and then in part switch to atazanavir (atv) + obt or atazanavir/ritonavir (atv/r) + obt , in part continue with lpv/r + obt . the objective was to characterize the changes of carbohydrate profile of a cohort of patients who made a switch from a regimen with lpv/r to boosted or unboosted atv.


Eligibility criteria:
inclusion criteria: * hiv postive patients * patients on stable and effective antiretroviral therapy with a protease inhibitor exclusion criteria: * use of atazanavir before the enrolment * pregnancy

Keywords: hiv diabetes glucose metabolism antiretroviral therapy ritonavir atazanavir
dynamo: a tailored lifestyle promotion intervention among pediatric patients with cardiometabolic risk factors

Conditions: Obese

Summary: the dyn@mo lifestyle intervention (chu sainte-justine, quebec, canada) targets children and adolescents aged 6 to 17 years old with cardiometabolic risk factors, such as obesity, hypertension, disorders in glucose regulation or dyslipidemia. its primary goal is to promote physical activity and reduce sedentary time to improve childrens' cardiometabolic profile. to do so, the intervention relies on gathering data on mobility and physical activity using wearable sensors. these data provide a detailed picture of real-life conditions and physical activity levels, improving the health care professional's ability to tailor counseling. the investigators are presently in the implementation phase of this intervention.


Eligibility criteria:
inclusion criteria: * children ages 6 to 18 years of age with a bmi \> 95th percentile for age and sex exclusion criteria: * children with a physical or psychological condition that would impair their ability to participate in physical activity

Keywords: obesity physical activity metabolism environment obese children, as defined by a body mass index > 95th percentile for age and sex
the inspire programme: developing an intensive suicide prevention therapy for suicidal prisoners

Conditions: Suicide

Summary: this study aims to assess the acceptability and feasibility of a short-term, intensive cognitive behavioural therapy (cbt) delivered to male prisoners who have thoughts of ending their lives.

10 hours of an adapted cbt therapy for suicide will be delivered across 2 weeks in 5 2 hour sessions to male prisoners. they will initially be assessed on several measures of mood, social support and suicidality. they will then undergo therapy. following this they will be asked to re-completed the initial measures and a post-therapy interview to ascertain their thoughts on their experience of the therapy.

Eligibility criteria:
inclusion criteria: * aged over 21 years old. * has been managed under the assessment, care in custody, and teamwork (acct) system within the last 1 month (including current acct review). * sufficient english language proficiency, as judged by the researcher, in order to complete psychometric questionnaires (i.e. adequate reading comprehension) and engage in intensive cbt programme (i.e. adequate verbal communication). * adult is able to provide informed consent as established during baseline clinical interview (bps, 2006; mca, 2005). * currently residing in hm prison (and expected to remain there for at least six weeks; determined through staff and prisoner report). exclusion criteria: * a primary organic disorder (indicated by prison medical staff report or records). * any current risk behaviour which would compromise the safety of others, as identified by prison staff.

Keywords: intensive cognitive behavioral therapy male prisoners
effectiveness of robotic assisted gait training in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: the purpose of the study is to investigate the effectiveness of robotic-assisted locomotor therapy on improvements of functional gait parameters in ambulatory children with cerebral palsy.

within a randomized controlled design the effects of robotic-assisted locomotor training (15 sessions within 5 weeks) will be examined in a sample of 34 children with cerebral palsy. children will be randomly assigned to an intervention or waiting list group. assessments will be performed at baseline, in week 6 as well as in week 12. the intervention is provided to the waiting list group after the assessment in week 6.

Eligibility criteria:
inclusion criteria: * bilateral spastic cerebral palsy * gross motor function classification scale (gmfcs) ii-iv exclusion criteria: * prior orthopedic surgery on the lower extremity or the trunk (\<6 months) * prior neurosurgical interventions (\<6 months) * significant mental retardation * severe contractures * prior lokomat training (\<6 months)

Keywords: child robotic-assisted treadmill training rehabilitation
the feasibility study of the li brush for the screening of endometrial cancer in the postmenopausal period

Conditions: Endometrial Neoplasms

Summary: investigators aim to collect endometrial sampling with li brush among target population who have risks for endometrial neoplasm, then fractional curettage should performed with these participants, investigators intend to compare the pathological diagnosis results of cytology and fractional curettage to evaluate the sensitivity of li brush and investigators expect that the brush can be used for screening of endometrial cancer in the postmenopausal period in the clinic.

investigators screen the suitable participants according to the inclusion and exclusion standards, and then collect their endometrial sampling with li brush. pathologists will help to decide the cytology obtained by li brush and histology diagnosis of the endometrial sampling. comparing the pathological diagnosis results of cytology and histology, investigators want to prove the feasibility of cytology diagnosis of endometrial cancer in the postmenopausal period, as the same time, investigators intend to evaluate the possible factors that affecting the precision of li brush for endometrial cancer in the postmenopausal period.

Eligibility criteria:
inclusion criteria: 1. postmenopausal abnormal uterine bleeding; 2. ultrasound of the pelvic showed thickened endometrial ( usually more than 5mm) ; 3. family history of endometrial cancers; 4. other participants with risks for endometrial cancer (such as fat, lynch syndrome and so on) exclusion criteria: 1. cervical cancer; 2. fever (body's temperature is higher than 37.5 degrees ); 3. vaginitis (excluding atrophic vaginitis); 4. patients who cannot bear the operation; 5. coagulation disorders; 6. pregnancy and suspected pregnancy.

Keywords: postmenopause endometrial sampling vaginal bleeding
a pilot study to explore the role of gut flora in chronic constipation

Conditions: Constipation; Constipation Chronic Idiopathic; Constipation - Functional; Constipation (Excl Faecal Impaction)

Summary: this study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding chronic constipation

the goal of this research study is to better understand how the genetic information in subject's microbiome correlates to the information provided in surveys and in medical records regarding chronic constipation.

Eligibility criteria:
inclusion criteria: 1. signed informed consent, demonstrating that the patient understands the procedures required for the study and the purpose of the study 2. male or female patients of any age (interest is given to children to compare with mothers) 3. diagnosis of chronic constipation exclusion criteria: 1. refusal to sign informed consent form 2. history of bariatric surgery, total colectomy with ileorectal anastomosis or proctocolectomy. 3. postoperative stoma, ostomy, or ileoanal pouch 4. participation in any experimental drug protocol within the past 12 weeks 5. treatment with total parenteral nutrition 6. any clinically significant evidence of disease that could interfere with the subject's ability to enter the trial 7. inability to adequately communicate with the investigator or their respective designee and/or comply with the requirements of the entire study
elderly hodgkin lymphoma patients treated with chemoradiotherapy

Conditions: Hodgkin Lymphoma, Adult

Summary: outcome of hodgkin lymphoma patients over than 60 years treated by chemotherapy and/or radiotherapy: retrospective analysis.


Eligibility criteria:
inclusion criteria: * patients over than 60 years * newly diagnosed hodgkin lymphoma exclusion criteria: * data not available
wash-in period in patients undergoing low flow anesthesia

Conditions: Inhalation Anesthesia

Summary: volunteers above the age of 18 and below the age of 60 who agreed to participate in the study were not exposed to any interventional intervention other than those routinely applied to the patient during and after the administration of the clinical standard anesthesia protocol. the value indicating the brain's response to hypnotic substances, the vapor concentration in the lung alveoli and the minimum amount of anesthesia gas used will be recorded at certain times. the aim of the researchers in the study was to observe the effect of two different fresh gas flow rates on the amount and cost of waste gas released into the atmosphere.

anesthetic management of a patient receiving general anesthesia consists of induction, maintenance and termination periods. in the "wash in period" (saturation of the circuit between the anesthesia device and the patient), high fresh gas flows, usually 2-4 l/min fresh gas flow (50% oxygen and 50% air/nitrous oxide mixture) are used. inhaled anesthetic agents are routinely used in resuscitation. however, the part of this inhaled agent that is not used by the patient is released into the atmosphere and environment. the higher the flow of fresh gas administered, the greater the proportion not used by the patient and discharged into the atmosphere. these waste gases contribute significantly to the greenhouse effect in the atmosphere. occupational exposure (liver-kidney disease, neurologic disease, cancer, spontaneous abortions, etc. in healthcare workers) accounts for the portion released into the environment. the consumption and cost of inhalation agents depends on the fresh gas flow rate, vaporizer setting and duration of anesthesia. it has been observed that reducing the fresh gas flow rate significantly reduces the cost. the aim of the researchers in the study was to observe the effect of a fresh gas flow rate of 1 l/min to 4 l/min on the amount of waste gas discharged into the atmosphere and thus on the cost of inhaled agents.

Eligibility criteria:
inclusion criteria: * asa i-ii risk group patients duration of surgery between 2 hours and 4 hours, cases with general anesthesia exclusion criteria: * patient refusal to participate in the study * under 18 years old bmi\>40 * patients receiving invasive mechanical ventilator support in the last 1 month * patients who have received chemotherapy or radiotherapy in the last 2 months * those with severe lung disease (copd, asthma, pulmonary infection, bronchiectasis, previous need for non-invasive mechanical ventilation, oxygen therapy or steroid therapy for acute attack) * known severe pulmonary hypertension * smoke poisoning (carbon monoxide, cyanide poisoning) * alcohol or acetone poisoning * malignant hyperthermia * intracranial tumor * hemodynamic instability * shock * neuromuscular disease * pathologies causing increased intracranial and intraocular pressure * those with severe cardiac arrhythmias those with -ef\<30 * severe peripheral arterial disease * patients with liver and kidney dysfunction
a trial of three types of enemas used to treat functional constipation in children

Conditions: Functional Constipation

Summary: functional constipation is extremely common in children and is defined as painful, hard stools or firm stools for twice or less per week. functional constipation accounts for 3% of general pediatric visits and up to 25% of pediatric gastroenterology visits. constipation and fecal impaction can lead to a range of symptoms including decreased appetite, vomiting, and abdominal pain frequently resulting in emergency department (ed) presentation. in contrast to the outpatient setting where diet and oral medications work well to relieve symptoms related to functional constipation, ed management requires an approach with quicker results. for immediate relief of symptoms, disimpaction via enema use may be better than polyethylene glycol (peg) 3350 for children. however, the type of enema to be used is not well studied. currently, any patient presenting to the ed with a presumed diagnosis of abdominal pain due to functional constipation receives an oral dose of peg and one of the following three types of enemas (based on the ed treating attending's discretion): phosphate or fleets enema, normal saline enema, or mineral oil enema. there is no evidence in the literature that demonstrates any difference in the effectiveness of each of these enemas. the investigators propose a randomized control trial of the three types of pediatric enemas readily used in our ed to determine the best approach. there will be three arms within this study: a) peg plus phosphate enema b) peg plus normal saline enema and c) peg plus mineral oil enema. the physicians enrolling patients will not be the treating physicians. the four principal investigators (blinded to the type of enema being used), following appropriate informed consent, will obtain pain scores (faces pain scale - revised) pre- and post-administration of each of the three treatments listed above in order to determine the best enema to use in children 4-12 years of age. other outcomes to be analyzed will include the patient's weight pre- and post-administration of the enema, satisfaction ratings on a visual analog scale from the treating physician (who will also be blinded), and parental surveys on the day of administration and 3-5 days following discharge. data analysis for pain scores will be completed with repeated measures anova. categorical values will be compared using chi square analysis and continuous variables will be compared using parametric statistics.


Eligibility criteria:
inclusion criteria: * age 4-12 years * receiving enema in ed for presumed constipation exclusion criteria: * critically ill patient * any history of renal insufficiency, renal disease, or elevated creatinine * any history of intestinal anatomic abnormality (i.e. anal stenosis, anal surgery, bowel obstruction, hirschprung's disease) * an inability to self-report pain * presence of gastrostomy or jejunostomy tube * any history of gastrointestinal dysmotility * inability to read or speak english or spanish

Keywords: constipation enema
ultra-wide-field fluorescein angiography in patients with macular edema secondary to retinal vein occlusion

Conditions: Retinal Vein Occlusion; Macular Edema

Summary: this study mainly observed the ischemic index and vascular leakage index changes on ultra-wide field fluorescence angiography after anti-vegf treatment , and whether these changes correlated with treatment efficacy in patients with macular edema secondary to retinal vein occlusion.

ultra-wide field fluorescence angiography can clearly observe the peripheral retina. this study mainly observes the ischemic index and vascular leakage index changes on uwfa after anti-vegf treatment and evaluates these changes associated with treatment efficacy in patients with macular edema secondary to retinal vein occlusion.

Eligibility criteria:
inclusion criteria: 1. male or female aged 18 years or older 2. macular edema secondary to crvo,brvo or hrvo 3. duration of rvo not more than 4 months 4. naïve patients. patient with previous rvo (more than 12 months before the inclusion date) completely resolved (normalization of visual acuity and fundus examination) and who have experienced a recurrence of rvo are also considered naive 5. patient who agrees to participate in the study and who has given his/her written, informed consent exclusion criteria: 1. patient with another retinal disease in the study eye: diabetic retinopathy, maculopathy of any cause (age-related macular degeneration, epimacular membrane, myopia, etc) responsible for decreased vision, advanced glaucoma, cataract severely affecting vision and/or requiring surgical treatment during the 24 months study period 2. active or suspected ocular or periocular infection 3. active severe intraocular inflammation 4. rvo complicated with neovascularization 5. patient who has previously undergone laser panretinal photocoagulation, grid-laser or photodynamic therapy, any anti-vegf or corticoids intravitreal injections in the study eye 6. patient already included in the study for the treatment of the fellow eye 7. pregnant or breastfeeding woman 8. lack of effective contraception for women of childbearing age 9. patient taking part in an interventional study

Keywords: ultra-wide field fundus fluorescein angiography ischemic index leakage index
state-dependent pathophysiological oscillations in parkinson's disease and treatment with deep brain stimulation (dbs)

Conditions: Parkinson's Disease

Summary: the purpose of this study is to use an investigational device to record brain activity for 12-24 months following surgical implantation of deep brain stimulation (dbs) systems. the goal of the study is better understanding of brain activity in parkinson's disease and how they relate to dbs and pharmacological management, not to bring new devices to market.

experimental: chronic brain recording this is a one-arm, single-center study of the neurophysiology of human movement disorders with two goals: 1) assess the feasibility of chronic brain recording using a novel fully implantable pulse generator (medtronic activa pc+s), which has the capability of sensing and storing local field potentials (lfps) recorded from implanted electrodes, in addition to providing therapeutic deep brain stimulation (dbs). 2) study acute and chronic effects of therapeutic dbs on cortical lfps. 3) study feasibility of the use of brain signals as feedback either directly to the patient or for dbs stimulation adjustments.

Eligibility criteria:
inclusion criteria: 1. diagnosis of idiopathic parkinson's disease (pd). 2. age 45-75 years 3. updrs iii motor score (off pd medications) ≥ 25 4. demonstrated good response (≥ 30%) to sinemet or dopamine agonist medications as assessed by total updrs iii score (off and on meds) 5. approved for unilateral subthalamic nucleus (stn)- or globus pallidus internus (gpi)-dbs surgery to treat their clinical motor signs and plan to undergo the standard of care procedure within the next four months 6. cleared to be scanned in a 7 tesla magnet 7. written documentation of willingness to participate in the study per protocol as evidenced by the informed consent process exclusion criteria: 1. clinically significant medical disease that would increase the risk of developing pre- or post-operative complications (e.g., significant cardiac or pulmonary disease) 2. evidence of secondary or atypical parkinsonism 3. dementia as evidenced by impairment in two neuropsychological domains and impaired or borderline neuropsychological function in one additional domain. 4. unable to undergo magnetic resonance imaging (e.g., due to incompatible implanted pacemaker) 5. previous pallidotomy or dbs surgery 6. women who are currently pregnant or are breast feeding 7. mri showing cortical atrophy out of proportion to age and/or mri showing focal brain lesions that could indicate a non-idiopathic movement disorder 8. any prior intracranial surgery 9. subjects with depression defined according to diagnostic and statistical manual v criteria and a scored on a validated depression assessment scale 10. history of seizures 11. immunocompromised 12. requires diathermy, electroconvulsive therapy (ect) or transcranial magnetic stimulation (tms) to treat a chronic condition 13. has an implanted electronic device such as a neurostimulator, cardiac pacemaker or medication pump.

Keywords: parkinson's disease
success rate evaluation of miniature pulpotomy with mta in primary molars

Conditions: Pulpitis; Dental Pulp Disease; Tooth Diseases

Summary: the purpose of this study is to evaluate the clinical and radiographic success rate of miniature pulpotomy with mineral trioxide aggregate (mta) in primary molars.


Eligibility criteria:
inclusion criteria: * healthy people(without any systemic disease) * teeth : * no clinical or radiographic evidence of pulp degeneration * the possibility of proper restoration of the teeth exclusion criteria: * teeth : * excessive bleeding from the exposure site * internal root resorption * interradicular and/or periapical bone destruction * swelling or sinus tract

Keywords: clinical signs child pulpotomy