Kornimate/medical-research-clean huggingface dataset:
topical treatment for tmj arthralgia

Conditions: TMJ Pain

Summary: the goal of this clinical trial is to evaluate the efficacy of topical 2.5% hydrocortisone in tmj arthralgia. the main questions it aims to answer are: * how does pain reduction compare? * how does improvement in jaw function limitation compare? * how do side effects compare? participants will * on day 1 be examined and report their pain level and jaw function limitation * on days 1-21, apply their cream four times a day * on day 21, report their pain level, jaw function limitation, compliance with instructions, and side effects. researchers will compare topical 2.5% hydrocortisone and topical 1% diclofenac to see if efficacy and side effects differ.

* person 2 will label creams, patient packets (pre-stamped envelope, questionnaire, consent form), and give packets to person 1 in the order in which they are to be dispensed. * person 1 will recruit all eligible patients in the order in which they are seen, enrolling all that consent. packets and gel will be given to patient, and written and verbal instructions, including that email will be sent saying "keep it up!" to remind them to continue applying get, as well as "please send us your questionnaire". consent forms will be stored in locked drawer. * person 1 will remind patient on days 7 and 14 to continue with the study * person 1 will remind patient on day 21 to mail back the completed questionnaire * person 1 will reach out to all patients from whom the questionnaire is not returned within 1 week of day 21, and do so at weekly intervals a minimum of 3 times. * person 1 will enter data in excel as it comes, reaching out to patients if there are questions. excel file uses random number id, not patient name, thereby anonymizing the data * persons 1, 2, 3, and 4 will decide which patient's data, if any, should be removed * person 1 will send complete anonymized excel data file (containing all patients) to person 3 * person 2 will determine, using random number generator, which group will be referred to as "group a" during the statistical analysis, and which will be referred to as "group b" * person 2 will tell dr. korczeniewska which data will be in group a, and which will be in group b * person 3 will perform statistical analysis * person 2 will reveal which group was hydrocortisone, and which was diclofenac

Eligibility criteria:
inclusion criteria: * arthralgia of at least 1 tmj for at least 3 days exclusion criteria: * systemic pain condition * past adverse reaction to steroid * currently taking steroid * taken steroid in the past ___ months * muscle relaxants (may start after study is complete) * new night guard during study, or within 1 month of start of study (may start after study is complete)

Keywords: diclofenac hydrocortisone tmj arthralgia
the safety of ropivacaine tap block combined with intravenous lidocaine in patients undergoing colorectal cancer surgery

Conditions: Colorectal Cancer

Summary: many studies have confirmed the analgesic effect of intravenous infusion of lidocaine in abdominal surgery. transversus abdominis plane (tap) block is also often recommended for abdominal surgery. ropivacaine tap block and intravenous lidocaine infusion are important components of multimodal analgesia for colorectal surgery. however, both of them are the local anesthetics and the safety of combination is unknown, so investigators design the study to explore the safety of the synergistic application of ropivacaine tap block and intravenous lidocaine infusion in patients undergoing colorectal surgery.

transversus abdominis plane (tap) block is often recommended for abdominal surgery. ropivacaine tap block and intravenous lidocaine infusion are important components of multimodal analgesia for colorectal surgery. however, both of them are the local anesthetics and the safety of combination is unknown, so investigators design the study to explore the safety of the synergistic application of ropivacaine tap block and intravenous lidocaine infusion in patients undergoing colorectal surgery.

Eligibility criteria:
inclusion criteria: 1. aged between 18 and 65 years; 2. patients who plan to undergo open/laparoscopic colorectal cancer resection surgery under general anesthesia; 3. american society of anesthesiologists (asa) physical status classification system i\~ii; exclusion criteria: 1. weight less than 40kg or more than 100kg; 2. defects in the cardiac conduction system (ii or iii degree atrioventricular block) or cardiac dysfunction (lvef\<50%); 3. severe liver dysfunction (alt, ast, bilirubin 2.5 times higher than normal), renal dysfunction (creatinine clearance rate\<60ml/min); 4. allergies to experimental drugs; 5. patients who are unable to communicate; 6. participating in other clinical researchers.
mechanical power normalized to compliance in ards

Conditions: Acute Respiratory Distress Syndrome

Summary: mechanical power (mp) is a summary variable, which includes static and dynamic respiratory parameters, is associated with ventilator-induced lung injury. mp is transferred primarily to smaller functional lung size, often referred to as "baby lung" (bl). functional lung size (bl) is associated with respiratory system compliance (crs). for this reason, mp normalized to crs (mp/crs) could be an important parameter to evaluate. the objectives of this study were to compare variables according to the mp/crs cut-off point and to identify the mp components associated with mp/crs.

in patients with acute respiratory distress syndrome (ards), undergoing mechanical ventilation (mv), each respiratory cycle transfers a specific amount of mechanical energy to the lung, aimed to expand and overcome airway resistance. the total mechanical energy multiplied by the respiratory rate (rr) defines the mechanical power (mp). it has been hypothesized that a smaller functional lung size, often referred to as "baby lung" (bl), increases mechanical energy transfer that exacerbates lung damage. functional lung size (bl) is associated with respiratory system compliance (crs). whatever the size of this operational bl, protective ventilation strategies should be aimed at preserving its size and functionality, to avoid ventilator-induced lung injury (vili). for this reason, mp normalized to crs (mp/crs) could be an important parameter to evaluate. preclinical studies have found that vili arises primarily from a combination of mp components and not from any of its components individually. we believe that mp/crs should have the same behavior in relation to mp components as a whole. therefore, the objectives of this study are to compare variables according to the mp/crs cut-off point and to identify the mp components associated with mp/crs.

Eligibility criteria:
inclusion criteria: * patients who have been receiving mechanical ventilation (mv) and have been defined as with ards according to the berlin definition exclusion criteria: * patients with chronic pulmonary disease * patients with an expected duration of mv shorter than 48 h * patients with a high risk of death within 3 months for reasons other than ards * patients having made the decision to withhold life-sustaining treatment.
registry study of coagadex® patients with moderate or severe hereditary factor x deficiency undergoing major surgery

Conditions: Factor 10 Deficiency

Summary: this is a non-interventional, multicenter, post-marketing registry study in three patients with moderate or severe hereditary fx deficiency, to assess coagadex administered peri-operatively for hemostatic cover in major surgery during routine post-marketing use.

the primary objective is to collect additional surgical data on the clinical effectiveness of coagadex, in a post-marketing environment, for peri-operative hemostatic cover during major surgery in patients with moderate or severe hereditary factor x (fx) deficiency. the secondary objective is to review safety data on coagadex through the collection of any adverse drug reactions (adrs) from the first dose of coagadex in the hospital prior to the surgical procedure until the first follow-up after discharge (i.e., follow-up completed) and serious adrs up until the post-operative care follow-up has been completed. data on any deaths and pregnancies reported within this time period will be collected.

Eligibility criteria:
inclusion criteria: * patients \>12 years of age with severe or moderate hereditary fx deficiency. severe is defined as \<1 iu/dl and moderate as 1 to 5 iu/dl (3) * patients who have given written informed consent (for sites in the usa this will include the health insurance portability and accountability act (hipaa) authorization statement), or, in the case of 12-18 year olds, written informed consent from the parents/ guardians and where appropriate assent from the child * patients requiring major surgery. major surgery is defined as procedures typically requiring: * full anesthesia or regional anesthesia, e.g. epidural or spinal and * involving the opening of major cavities such as thoracic, abdominal surgery; orthopedic surgery, and caesarean section (c-section) and * requiring at least one overnight stay in hospital (16) exclusion criteria: * patients known to be pregnant, unless the surgery is c-section. * patients who participated in a clinical study trial in the last 30 days prior to study enrolment, except if they have been involved in another study involving coagadex. * patients with a known history of inhibitor development to fx. * patients who are required or expected to take other factor x-containing medications during or after surgery. * patients with existing known thrombocytopenia (platelets \< 50 x 109/l). * patients with existing known clinically significant renal disease (creatinine \>200 µmol/l). * patients with existing known clinically significant liver disease (alt levels greater than three times the upper limit of normal). * patients with existing known other coagulopathy or thrombophilia. * patients with a known intolerance or allergy to coagadex or its excipients. * patients known to have abused chemicals or drugs within the past 12 months. * patients with a history of unreliability or non-cooperation.
a pilot study non-invasive guidance for therapeutic ultrasound treatment of lower back muscle injuries

Conditions: Injury; Muscle, Back, Lower

Summary: back injuries are the most common reason people seeking for effective treatment. one of the most common treatments in sports medicine for muscular injuries is therapeutic ultrasound, which is designed to heat the injured tissue and increase the flow of blood to promote healing.

researchers at beckman laser institute, using a technology developed at university of california, irvine. the device call diffuse optical spectroscopy, this device developed with harmless light that can measures and detect the change of blood flow, oxygen level, temperature and muscle tissue in lower back during therapeutic ultrasound therapy treatment. the researchers can provide information in real-time tissue change before, during, and after treatments that can determine the effectiveness of the treatment and speed up recovery time.

Eligibility criteria:
inclusion criteria: * male or female over 18 years of age, * no back injuries, no plan treatment * currently diagnose with back injuries, with plan treatment of therapeutic ultrasound exclusion criteria: * minors * obese * pregnant
remote training in evidence-based practices for clinicians who work with migrant workers

Conditions: Depression

Summary: this study will compare training as usual to automated training using an intelligent tutoring system in training bachelors (ba) level social workers in cognitive behavioral therapy (cbt). the purpose of the study is to determine if time and cost of training front line clinicians in evidence-based treatments can be shortened, and if this new training model can reduce the need for clinicians to seek advice from experts.

the university of washington (uw) school of social work, in partnership with heritage university's school of social work in yakima valley recently partnered to develop a training program for bachelors (ba) level social workers to address limited clinician capacity in rural primary care settings. currently the curriculum is a combination of didactic training in telephone based cognitive behavioral therapy (cbt; 20 hours), role play training (25 hours), and guided supervision. the scalability of these programs is limited, however, by expert time to conduct training activities, clinician time away from work to engage in training activities, and the fact that even when clinicians participate in training, there is no guarantee they will certify. adaptive learning, an educational method that uses adaptive algorithms to may be a potential solution to these problems in capacity building. these programs can tailor the educational experience to the needs of the trainee, reduce time in training, improve competence in complex decision-making and standardize training. this study builds on the existing research base on clinical training, and adds to it by designing and testing an intelligent tutoring system (its) based on adaptive learning algorithms. both cbt experts (aisenberg) and past cbt trainees (heritage university school of social work) will partner with experts in educational software development (popovic) to create the its, which will be compared to training as usual on time to training, competence and skill drift. the investigators hypothesize that capacity building through improved learnability (target mechanism) will result in enhanced clinical ability to deliver cbt elements competently, and in a shorter time-period, and that greater competence will result in better quality of care.

Eligibility criteria:
inclusion criteria: * ba level social work student * bilingual spanish speaking exclusion criteria: * none

Keywords: workforce development intelligent tutoring systems
pain, fatigue and life quality in covid-19 patients

Conditions: COVID-19 Pneumonia; Pain; Fatigue; Quality of Life

Summary: the aim in this study is to evaluate pain, fatigue and quality of life in patients with covid-19 pneumonia in long-term follow-up and to investigate their relationship with pneumonia severity, age, presence of comorbidity and depression level.

patients over the age of 18 who are hospitalized in the pandemic service, and are positive for covid-19 pcr, will be included in the study if the participants read the informed consent form and volunteer for the study. patients' age, comorbidities, initial symptoms, and pneumonia severity (mild/moderate/severe) will be recorded. pain, fatigue and depression assessments will be made on the first day of hospitalization, at discharge, at the 1st month and 3rd month after discharge. the 1st and 3rd month evaluations of the patients will be made by contacting the participants by phone. in addition to the 1st and 3rd month evaluations, the quality of life will also be evaluated with the sf-12 questionnaire.

Eligibility criteria:
inclusion criteria: patients over the age of 18 who are hospitalized in the pandemic service, and are positive for covid-19 pcr, will be included in our study. * patient with covid 19 pneumonia exclusion criteria: * uncooperative patient, * illiterate patients, * pregnancy, * patients with chronic pain or fatigue in the last 6 months (before covid-19 disease), * patients who were admitted to the intensive care unit during their hospitalization

Keywords: covid-19 pneumonia pain fatigue quality of life
a non-invasive cervical cancer screening modality: a pilot study

Conditions: Women With Abnormal Pap Smears

Summary: cervix cancer is a major global health concern. a way to screen and immediately treat precancerous lesions (screen-and-treat) is greatly needed. developed by mobileoct, polarized difference imaging and conventional imaging are used to identify suspicious lesions. we aim to compare this non-invasive method with colposcopy. patients at the dickens clinic will have 3-5 minutes of non-invasive imaging before colposcopy. pathology will be compared both to colposcopy impression versus mobileoct.


Eligibility criteria:
inclusion criteria: * subjects capable of giving informed consent or have an acceptable surrogate capable of giving consent on subjects behalf. * subjects are 18 years of age or older * subjects are scheduled for colposcopy clinic based on screening with abnormal pap smear or have repeat colposcopy indicated for specific clinical indications, based off of american society of cosposcopy and cytology. * subjects are women. exclusion criteria: * pregnancy. * males (males do not have a cervix and thus cannot undergo colposcopy).
oxygen versus medical air for treatment of csa in prader will syndrome

Conditions: Sleep Apnea, Central; Prader-Willi Syndrome

Summary: the aim of this study is to determine if treatment with medical air (21% oxygen in room air) compared to supplemental oxygen (100% oxygen) will lead to similar improvements in the central apnea-hypopnea index (cahi) for infants with prader-willi syndrome. despite the vast amount of research investigating the cause of central sleep apnea, there remain gaps in knowledge, lending to further research efforts. the decision to compare oxygen to medical air is based on several theorized mechanisms. the first of which is the supposition that provision of medical air may act as an arousal stimulus for the hypothalamus, thereby preventing sleep disordered breathing. secondly, the hypercapnic challenge performed by livingston et al demonstrated a delayed hypercapneic arousal response in pws subjects despite simultaneous hyperoxia, leading us to question if therapeutic oxygen really plays a significant role in treating csa. lastly, the delivery of medical air via nasal prongs may provide sufficient arousal to terminate the cycle of events leading to central apnea, as described by urquhart et al. a deeper understanding of central sleep apnea is essential to ameliorating its adverse sequelae, which include symptoms of adhd, impaired attention, behavioral problems, and academic difficulties.


Eligibility criteria:
inclusion criteria: 1. infants under age two with genetically confirmed prader-willi syndrome 2. referred to hsc sleep clinic for evaluation with polysomnogram prior to initiation of growth hormone 3. infants found to have clinically significant central sleep apnea, defined as an apnea-hypopnea index (ahi) equal to or greater than 5 exclusion criteria: 1. infants delivered prematurely (less than 37 weeks gestational age) 2. term infants with a history of hypoxic-ischemic encephalopathy or stroke 3. any concurrent diagnoses that may cause sleep-disordered breathing (ie. craniofacial abnormalities, arnold-chiari malformation, etc) 4. infants with a need for daytime supplemental oxygen (ie. cardiac anomalies) 5. infants found to have low baseline oxygen saturations on psg
the study of the association between the gut microbiota and central serous chorioretinopathy

Conditions: Central Serous Chorioretinopathy

Summary: to investigate the potential association between gut microbiota and central serous chorioretinopathy (csc), we have observed in our clinical practice that csc patients often experience chronic gastrointestinal issues. this observation has led us to hypothesize that csc may be associated with gut dysbiosis. the bifidobacterium genus is widely recognized as a beneficial gut bacterium, and numerous well-established bifidobacterium supplements are available on the market. to explore this possible connection, we will collect fecal samples from both csc patients and healthy individuals. using whole-metagenome shotgun sequencing, we will compare the gut microbiota compositions of the two groups to determine if significant differences exist. additionally, we will randomly assign patients to two groups: one group will receive bifidobacterium supplements for at least one month, while the other group will receive a placebo. we will then assess whether the group receiving the supplements experiences faster recovery and lower relapse rates compared to the placebo group.


Eligibility criteria:
inclusion criteria: * age 18 to 60 years * diagnosis of acute central serous chorioretinopathy (csc) (affected eye: ① ffa and icga showing typical csc manifestations, ② presence of subretinal fluid (srf) at the macular fovea, ③ disease duration ≤ 6 months) * best corrected visual acuity (bcva): 53 to 86 letters * other: no significant systemic diseases, signed informed consent, and able to commit to follow-up exclusion criteria: * presence of significant systemic diseases * bcva of 20/200 or worse * presence of choroidal or retinal atrophy in the macular fovea of the affected eye * presence of choroidal neovascularization (cnv), age-related macular degeneration (amd), polypoidal choroidal vasculopathy (pcv), diabetic retinopathy (dr), choroidal hemangioma, pigment epithelial detachment (ped), etc., in the affected eye * high myopia in the affected eye

Keywords: central serous chorioretinopathy bifidobacterium genus the gut dysbiosis
buprenorphine/naloxone treatment for opioid dependence-experiment 1 - 1

Conditions: Heroin Dependence; Opioid-Related Disorders

Summary: the purpose of this study is to assess the clinical efficacy of the buprenorphine/naloxone combination tablet for alternate-day dosing and determine whether multiples of the daily dose are necessary to maintain an effective alternate day dosing regimen.

alternate-day dosing with the 8mg buprenorphine-naloxone tablet is as safe and effective as daily dosing. outcomes are improved when the total weekly dose provided during alternate-day dosing is equal to that given during daily dosing.

Eligibility criteria:
inclusion criteria: individuals must be currently opioid dependent and meet fda criteria for narcotic maintenance treatment. co-morbid substance abuse or dependence disorders may also be present. individuals must be healthy despite drug dependency. exclusion criteria: individuals with evidence of an active diagnostic and statistical manual of mental disorders (dsm-iv) axis i psychiatric disorder (e.g. psychosis, manic-depressive illness, organic psychiatric disorders), significant medical illness (e.g. liver or cardiovascular disease) or pregnant female subjects are excluded from study participation.

Keywords: heroin dependence
late dislocation of intraocular lens (iol) following cataract surgery: an evaluation of two different surgical methods

Conditions: Intraocular Lens Dislocation

Summary: a prospective randomized study on patients with late in the bag intraocular lens (iol) dislocation, after cataract surgery. to obtain normal visual function, these patients needs surgery. in this study the investigators will look for advantages and dis-advantages after two different surgical approaches to late in-the-bag iol dislocation.

in this prospective, randomized study the investigators will include at least 80 patients with late intraocular lens (iol) dislocation in the capsular complex, after cataract surgery. to obtain normal visual function, these patients needs surgery. today, there are two different methods used for this condition; scleral suturing of the capsular complex or exchange of iol to an iris-fixated iol (verisyse). in this study the investigators will look for advantages and dis-advantages for these two methods.

Eligibility criteria:
inclusion criteria: * patients with dislocation of iol in the capsular complex who agree to participate in the study exclusion criteria: * patients with total dislocation of the capsular complex' * patients with reduced general health * patients who can't be randomized

Keywords: cataract surgery scleral suturing verisyse late in-the-bag iol dislocation