Kornimate/medical-research-clean huggingface dataset:
preventive fixation of lower limbs in osteogenesis imperfecta (brittle bone disease) with the highlight of the fassier-duval

Conditions: Brittle Bone Disease

Summary: osteogenesis imperfecta (or brittle bone disease) is a rare genetic disease characterized by fragile bone and a low mass ossue, secondary to abnormal collagen synthesis. this is a real congenital osteoporosis. the prevalence of the disease is not known precisely, but it is 1 in 10000 at 20000. there are many forms of osteogenesis imperfecta to classify patients with symptomatology minor to the patients with lethal form during the neonatal period. the main symptoms are dominated by fractures and bone deformities, particularly in the lower limbs. bisphosphonate medication is used for over 10 years to reduce the number of fractures. however the long-term effects are not known to date, not allowing even to establish proof of the benefit risk. thus unable to process all of these patients and over a long time, these drug treatment leaves much therapeutic solutions to surgery. the goal of surgery is to treat fractures, treat bone deformities and prevent fractures future. in the long bones of the limbs, the only effective techniques are intramedullary nailing. the majority of realized nailing nailing are either sliding or telescopic enabling having a reinforced bone of an intramedullary osteosynthesis material over its entire length during the period of bone growth. it has been shown that the technique of the sliding nailing was inexpensive but reliable especially before the age of 5 years. after that age, all are telescopic nailing nailing. the first telescopic nail described is the bailey-dubow nail still widely used in france. however, the number of complications relating to its use is important. thus, there are 8% of disunity equipment and 33 to 72% of the nail migration forcing him to change one or more times during growth. a new nail presented at the french orthopedic company in 2005 and fassier duval reported a much lower complication rate because the rate of nail migration is only 9%, without opening the knee joint, which is not possible with the highlight of bailey-dubow. it is proposed to conduct a prospective series of 10 nailing the lower extremities with this nail fassier-duval in patients with osteogenesis imperfecta and compare the results with a series of patients already treated with bailey-dubow nails in order to highlight the advantages and disadvantages of using of such a nail.


Eligibility criteria:
inclusion criteria: * minor patient, male or female patients with osteogenesis imperfecta * patients who were operated on for intramedullary nailing of the femur or tibia by a nail-bailey dubow or sliding nailing between 1996 and 2010 * patients with surgical management of the disease was performed in the orthopedic surgery department of the assistance publique hôpitaux de marseille exclusion criteria: * non patients with osteogenesis imperfecta * major patients * patients who have never had nailing of the femur or tibia by a nail-bailey dubow or sliding nailing
the influence of obesity on level of depression and cognitive and executive functions

Conditions: Obesity

Summary: the proposed study is a randomized, open, comparative research involving an intervention group and two control groups. the aims of the study are: 1.to compare levels of depression in female adolescents with obesity and a control group of female adolescents with appropriate weight and height. 2. to investigate whether a decrease in weight due to a short range intervention program provided by dietician for female adolescents with obesity will lead to change in the levels of symptoms of depression and cognitive and executive functions in comparison to a control group of adolescent girls with obesity, matched in age that does not receive such an intervention program. 60 female adolescents with obesity will be recruited to the study and will be randomized to 1 of two groups- 1. intervention group- participants in this group will attend an intervention program consisting of 12 meetings with dietician and will attend two study visits at the clinic- in the beginning of the study and after three months. 2.control group- participants in this group will only come to two study visits at the clinic. in the first two visits they will meet with a dietician and will receive nutrition guidance. another 30 girls with appropriate weight will be recruited to second control group- this group will come to two study visits at the clinic- in the beginning of the study and after three months. in the first visit participants will receive nutrition guidance by the dietician. in the study visits the following procedures will be performed for all study groups: blood tests, completion of psychological and nutritional questionnaires, completion of computerized tests and measurements of height, weight, fat mass and circumference of hips.


Eligibility criteria:
inclusion criteria: 1. adolescent girls aged 12-17, who attend the endocrinology institute in schneider hospital and comply with the research criteria: obesity (bmi above percentile 85) and appropriate weight (bmi between percentiles 5-85). 2. adolescent level according to tanner: 4-5. 3. participants with obesity: bmi above percentile 85 for age group. 4. participants in control group with appropriate weight: bmi percentile 5-85 for age group. 5. appropriate height (percentiles 3-97 according to the cdc curve). 6. parents' signature on informed consent form. exclusion criteria: 1. chronic illness or chronic use of medications. 2. inability to comply with the research conditions.
genetic factors and interrelationships for sexual orientation, susceptibility to hiv and kaposi's sarcoma, alcoholism and psychological traits, and histocompatibility antigens

Conditions: Alcoholism; HIV Infection; Homosexuality; Kaposi's Sarcoma

Summary: we propose to test, by dna linkage analysis of family pedigree members, the following interrelated hypotheses: 1) that sexual orientation is genetically influenced; 2) that the development of kaposi's sarcoma and other outcomes of hiv infection in male homosexuals is affected by host susceptibility genes, circulating sex hormone levels, or hla haplotype; and 3) that alcoholism and other psychobehavioral conditions are associated with homosexuality on a genetic basis and/or influenced by candidate behavioral loci. the subjects for these studies will be self-identified male and female homosexual probands and their relatives from families in which there are at least two individuals with homosexual orientation. all subjects will be adults, and will be referred through nih physicians, private practitioners, and gay and lesbian organizations. subjects will undergo a sexual orientation and behaviors interview, a psychiatric interview, and phlebotomy for hiv testing, hla determination, endocrine measurements, and preparation of dna from cultured lymphocytes. the dna samples will be analyzed for a series of genetic markers that span the human genome and for candidate loci chosen for function.

we propose to test, by dna linkage analysis of family pedigree members, the following interrelated hypotheses: 1) that sexual orientation is genetically influenced; 2) that the development of kaposi's sarcoma and other outcomes of hiv infection in male homosexuals is affected by host susceptibility genes, circulating sex hormone levels, or hla haplotype; and 3) that alcoholism and other psychobehavioral conditions are associated with homosexuality on a genetic basis and/or influenced by candidate behavioral loci. the subjects for these studies will be self-identified male and female homosexual probands and their relatives from families in which there are at least two individuals with homosexual orientation. all subjects will be adults, and will be referred through nih physicians, private practitioners, and gay and lesbian organizations. subjects will undergo a sexual orientation and behaviors interview, a psychiatric interview, and phlebotomy for hiv testing, hla determination, endocrine measurements, and preparation of dna from cultured lymphocytes. the dna samples will be analyzed for a series of genetic markers that span the human genome and for candidate loci chosen for function.

Eligibility criteria:
inclusion criteria: the basic criterion for entering families into the dna linkage study is the presence of two or more homosexual siblings of the same sex. additional criteria will be imposed depending on the aims of the particular project.

Keywords: genetic linkage sex behavior aids alcohol dependence hla system cancer
mechanistic and molecular study of the process of metastatic dissemination in colorectal cancer

Conditions: Colorectal Cancer

Summary: to confirm the role of the collective dissemination in the mechanisms of tumoral invasion of colorectal cancers


Eligibility criteria:
inclusion criteria: * age \> 18 years * histological diagnosis of stage iv colorectal cancer * hepatic metastasis and/or peritoneal potentially resecable * patient affiliated with a mode of the social security or recipient of such a mode * information of the patient or his legal representative and collection of his assent exclusion criteria: * none metastatic colorectal cancer * cancer of appendicular origin * patients deprived of liberty or unable to give his assent
a novel role of alpha lipoic acid in comparison with selenium in mitochondrial resuscitation and mirna-126 expression in hemodialysis patients

Conditions: Antioxidative Stress; End Stage Renal Disease on Dialysis

Summary: an open labeled, paralled, randomized, prospective, study was conducted on 60 patients who were randomized into 3 groups, 22, 20 and 18 patients in control, selenium and, thiotacid groups respectively. serum levels of ros, coq10, and mirna-126 were assessed at base line and after three months for all patients.


Eligibility criteria:
inclusion criteria: * prevalent hemodialysis patients exclusion criteria: * patients with inflammatory diseases, hepatic or respiratory diseases, smokers and alcoholics, were excluded from the study.

Keywords: oxidative stress antioxidants mitochondrial function coq10 mirna-126 hemodialysis
group-based chronic kidney disease care

Conditions: Chronic Kidney Disease; Hypertension

Summary: a two-group randomized clinical trial testing whether group-based care is feasible and will help improve blood pressure control in adult and adolescent patients with chronic kidney disease and hypertension.

this two-group rct will enroll 100 subjects, adolescents over or equal to 12 years of age, and men and women over age of 21, with stage 3-4 and 5 ckd from various causes including diabetes and hypertension. patients will be recruited from the montefiore medical center nephrology. the primary aim will be to assess feasibility of the intervention. informed consent will be obtained on all subjects. all subjects with meet with one of the investigators who will verbally explain to them the purpose of the study and the alternatives. blood and 24 hr urine test will be collected to assess for sodium, phosphorus, and serum creatinine. these tests will be used for experimental purposes only and will be collected at enrollment and 6 months visit. there will be two arms, an arm randomized to group-based care attending monthly outpatient clinic visits as part of a group and the other to usual care who will see their provider once a month for 6 months.

Eligibility criteria:
inclusion criteria: * adolescent age ≥12 years old * sufficient hearing, vision, and proficiency in english or spanish to comprehend low- literacy printed educational materials and participate in group sessions (assessed by provider) * adult: (¬\>21 years): systolic blood pressure \>140 at two clinic visits in the past year or \>160 at one visit and adolescent: (12-21 years) systolic blood pressure \>95 percentile (based on sex and age) at 2 clinic visits in the past year * for adults: stage 3-5 ckd (egfr\<60 ml/min/1.73m2) * for adolescents: evidence of kidney damage (albuminuria, congenital anomalies of the kidney or urinary tract) and hypertension * prescription for anti-hypertensive medication (in adults) * unwillingness to accept random assignment * unwillingness to provide informed consent exclusion criteria: * transplanted organ * rapidly deteriorating kidney function with the expectation for initiation of dialysis in less than 6 months * plans to relocate out of new york city in the next 6 months

Keywords: adherence exercise
comparison of clinical outcomes in ziemer femtosecond versus conventional phacoemulsification surgery

Conditions: Visual Outcomes

Summary: this study is aimed to compare the clinical outcomes in ziemer ldv z8 femtosecond laser-assisted cataract surgery versus conventional phacoemulsification cataract surgery

this study is aimed to compare the clinical outcomes in ziemer ldv z8 femtosecond laser-assisted cataract surgery versus conventional phacoemulsification cataract surgery. this study will be a non-inferiority study and ninety-five patients will be recruited.

Eligibility criteria:
inclusion criteria: 1. a cataract will be defined as clouding of the lens that interferes with normal vision. 2. not relevant, as study not on cancer patients. 3. only patients older than 50 years will be included, as cataracts develops with increasing age. no gender criteria are applied. 4. only individuals with the mental capacity to provide informed consent with be included. more specifically, all the following inclusion criteria must be met: 1. patients have medically dilated pupil size of at least 4.0mm. 2. patients are willing and able to sign a written informed consent form prior to any study-specific procedures. 3. patients are willing and able to return for scheduled follow-up examinations for 12 months after the cataract surgery. exclusion criteria: 1. patients with prior history of pseudoexfoliation syndrome. 2. patients with a prior history of glaucoma filtration surgery. 3. patients with optic atrophy. 4. patients with ocular pathology or disease (including pupil pathology such as fixated pupils) that might confound the outcome or increase the risk of adverse event.. 5. patients with a prior history of vitrectomy. 6. patients with a prior history of cataract or refractive lens surgery 7. patients with central corneal scarring. 8. patients with residual, recurrent, active or uncontrolled eyelid disease. 9. patients with significant corneal asymmetry or irregular topography. 10. patients with anterior segment pathology. 11. patients with any corneal abnormality 12. patients with any progressive retinal disease or subjects with a history or evidence of retinal vascular occlusion and/or hypercoagulability, because of the risks associated with high pressures during suction application. 13. patients with amblyopia or strabismus or those who are at risk for developing strabismus postoperatively as determined by corneal light reflex and cover-uncover testing. 14. patients who are pregnant, lactating, of child-bearing potential and not practising a medically approved method of birth control, or planning to become pregnant during the course of the trial, and patients with other conditions associated with fluctuation of hormones that could lead to refractive changes.
use of "smart wheelchairs" to provide independent mobility to visual and mobility impairments

Conditions: Blindness; Spinal Cord Injury

Summary: the goal of this project is to evaluate the smart wheelchair component system (swcs) for power wheelchairs and the smart power assistance module (spam) for manual wheelchairs in realistic indoor environments with target users performing realistic tasks. we will combine group trials involving individuals who have a visual impairment (but do not have a mobility impairment) with several single-case studio involving individuals who have a visual and mobility impairment. our long-term objective is to provide independent mobility to veterans with mobility and sensory impairments.

there are currently very few mobility options for veterans who have a mobility impairment and visual impairment, and this population will grow as the number of older veteran's increases. the goal of this project is to evaluate the smart wheelchair component system (swcs) for power wheelchairs and the smart power assistance module (spam) for manual wheelchairs in realistic indoor environments with target users performing realistic tasks. we will combine group trials involving individuals who have a visual impairment (and may or may not have a mobility impairment) with several single-case studies involving individuals who have a visual and mobility impairment. the key questions that will be addresses by the proposed research are: can smart wheelchair technology improve performance on realistic navigation tasks for individuals with visual and mobility impairments? will smart wheelchair technology increase the amount of independent travel by individuals with visual and mobility impairments? will using a smart wheelchair for an extended period of time diminish a person's ability to operate a "traditional" wheeled mobility aid?

Eligibility criteria:
inclusion criteria: * all participants will be completely blind * participants will be able to operate a power wheelchair with joystick control * participants will be able to push a manual wheelchair a minimum of 300 yards exclusion criteria: * mobility impairment

Keywords: aging blindness wheelchairs spinal cord injury
intra-individual reproducibility of the non-invasive assessment of the portal circulation

Conditions: Hepatitis C, Chronic; Non-Alcoholic Fatty Liver Disease

Summary: hepquant tests are new liver tests that are being developed to accurately measure liver function with sensitivity and specificity while being safe and non-invasive. the primary goal of this study is to define the intra-individual reproducibility of the hepquant tests, that is, to see if a person is given the tests several times that the test results are essentially the same each time. subjects for this study will include healthy controls and patients with chronic liver diseases. the chronic liver diseases will include hepatitis c virus (hcv) infection and a serious form of fatty liver disease, known as non-alcoholic steatohepatitis (nash). the hcv and nash patients will include men and women, and those with early stage and late stage liver disease as defined by the amount of fibrosis observed in their liver biopsies. once a subject has been enrolled in the study they will be given the hepquant tests on three separate days within the span of one month. the hypothesis of this study is that hepquant tests will reproducibly report liver function in healthy controls and patients with all stages of chronic hcv and nash liver disease and that liver function will decrease as the amount of liver fibrosis increases in the chronic liver disease patients.


Eligibility criteria:
inclusion criteria: * diagnosis of chronic hcv or nash * liver biopsy within 2 years of enrollment * compensated liver disease exclusion criteria: * decompensated liver disease * currently being treated with beta blockers, ace inhibitors, or other agents affecting fmd * malignancy diagnosed within 5 years of study enrollment without demonstrated clearance * history of congestive heart failure * renal insufficiency with chronic kidney disease stage 4 or 5 (gfr \< 30 ml/min/1.73m2) * crohn's disease or any active intestinal inflammatory condition * having an ileal resection * diabetic gastroparesis * pregnancy or intent to become pregnant. urine pregnancy tests will be performed at each visit. * inability to consent for one's self

Keywords: hepatitis fatty liver
atorvastatin in patients with ulcerative colitis

Conditions: Inflammatory Bowel Diseases

Summary: ulcerative colitis (uc) is an idiopathic, chronic inflammatory disease characterized by diffused inflammation of the colon and rectum mucosa; however, the exact underlying mechanisms of uc remain poorly understood. statins exert numerous pleiotropic effects including anti-inflammatory, antioxidant properties, endothelial function improvement, and immunomodulation independent of their basic lipid-lowering property.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * both male and female will be included * negative pregnancy test and effective contraception exclusion criteria: * breastfeeding * significant liver and kidney function abnormalities * colorectal cancer patients * patients with severe uc * patients taking rectal or systemic steroids * patients taking immunosuppressives or biological therapies
effects of artificial sweeteners on glucose metabolism in patients with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: to investigate the effects of artificial sweeteners on glucose metabolism in newly diagnosed type 2 diabetic patients

artificial sweeteners are among the most widely used food additives worldwide. artificial sweeteners consumption is considered safe and beneficial owing to their low caloric content. however, recent studies demonstrated that consumption of commonly used artificial sweeteners formulations drives the development of glucose intolerance in healthy human subjects. however,the effects of artificial sweeter on glucose metabolism in newly diagnosed type 2 diabetic patients remains unknown. thus, different doses of sweeteners will be given to newly diagnosed type 2 diabetic patients to investigate the effects of artificial sweeteners on glucose metabolism.

Eligibility criteria:
inclusion criteria: * participants with newly diagnosed type 2 diabetes, diagnosed by world health organization criteria, were recruited from outpatient of the endocrinology department in shanghai renji hospital, shanghai punan hospital，shanghai shibei hospital, shanghai xinhua hospital, chongming branch; * fbg≤ 9 mmol/l, hba1c≤ 7% ;without any oral hypoglycemic agents or insulin, * age ≥30 and ≤ 60 years old. * bmi \>24 and \<28 kg/m2; --no regular consumption of artificial sweeteners or foods that have added much sweeteners.(eg:coca-cola zero), no sucralose intolerance. exclusion criteria: * patients who had a history of acute and chronic diarrhea or constipation or severe chronic gastrointestinal disease.. * underwent enterectomy or other abdominal surgery (e.g., gallbladder removal) within one year; * take antibiotics, antidiarrheic, antispasmodic, steroids and immune agents within three months. * patients who had a history of abnormal renal function(creatinine \>132μmol/l), active liver disease(alt were 2.5 times higher than the normal upper limit), or accompany with other sever diseases, such as severe infection, severe anemia, neutropenia and mental illness. * other serious heart disease, such as congenital heart disease, rheumatic heart disease, hypertrophic or dilated heart disease,cardiac function(nyha) classification\>level iii. * a history of acute complications such as diabetic ketoacidosis or hypertonic coma within 3 months. * pregancy * allergic to sweeteners. * participant in any clinical trail within 3 months

Keywords: artificial sweetners glucose metabolism type 2 diabetic patients