Kornimate/medical-research-clean huggingface dataset:
vitamin d retrospective study and role with disease

Conditions: Vitamin D Status; Glucose Tolerance; Blood Pressure; Bone Mineral Density; Hyperlipidemia

Summary: vitamin d deficiency is associated with a heightened risk for developing type 2 diabetes, hypertension, and osteopenia/osteoporosis. vitamin d is made in the skin when it is exposed to sunlight and it is also obtained from the diet and dietary supplements. older people, individuals with high skin pigmentation, obese and sedentary individuals have low levels of vitamin d because pigmentation blocks vitamin d production in the skin, aging and physical inactivity are associated with reduced exposure to sunlight, and obesity is associated with the storage of vitamin d in fat preventing its utilization by muscle, bone and other tissues that require its metabolic action. these conditions are also associated with heightened risk for developing type 2 diabetes, glucose intolerance, hypertension, and osteopenia/osteoporosis in older and obese individuals. this is particularly heightened in older women who tend to have increased body fat, are more physically inactive and are at high risk for central obesity and its metabolic consequences of diabetes, hypertension and osteoporosis.

the heightened prevalence of obesity in aging especially in postmenopausal women suggests that interventions to raise vitamin d levels might be preventive of these diseases. investigators have completed studies of the effects of weight loss and exercise interventions in approximately 400 older women and men over the last 15 years, many of whom are obese. investigators have data on glucose tolerance, blood pressure and bone density in these studies and stored plasma in which investigators can analyze vitamin d levels. vitamin d may be an important risk factor for these metabolic diseases and the availability of these samples for vitamin d analysis will allow investigators to perform a cross-sectional study to address relationships of vitamin d levels to glucose intolerance and diabetes, hypertension/blood pressure status, bone mineral density, the degree of obesity, and physical activity status measured as maximal aerobic capacity and accelerometry in these older men and women. the results of this study have the potential to impact clinical practice in the prevention and treatment of diabetes, hypertension, and osteopenia/osteoporosis. this would circumvent the current dilemma for prevention of these chronic diseases through treatment of obesity, as these data would provide immediate prospects for changing the recommended doses of vitamin d beneficial for reducing risk for these diseases. the purpose of this study is to 1) determine the prevalence of vitamin d deficiency in obese, older men and postmenopausal women and 2) the association of vitamin d levels to glucose tolerance, blood pressure, bone mineral density, and hyperlipidemia, as well as association with vitamin d receptor gene polymorphisms affecting metabolic responses to vitamin d.

Eligibility criteria:
inclusion criteria: 45-85 years of age exclusion criteria: none -

Keywords: vitamin d diabetes osteoporosis cardiovascular risk
trichoscopy and systemic scleroderma

Conditions: Scleroderma, Systemic

Summary: * few data are available on scalp involvement in systemic scleroderma. * few data are available on the association between scalp abnormalities and features of systemic scleroderma * trichoscopy is a simple, reproducible, noninvasive examination that is part of the examination of hairy areas in routine dermatologic practice * there is a lack of simple, noninvasive examinations to evaluate patients with systemic scleroderma the objective will be to evaluate the contribution of trichoscopy in the evaluation of patients with systemic scleroderma


Eligibility criteria:
inclusion criteria: * patient who fulfils the systemic scleroderma acr-eular 2013 criteria * signed informed consent * being social insured exclusion criteria: * patients aged less than 18 years old * patients under legal protection * patients deprived of their liberty * patients in emergency situations * patients who refused or unable to give informed consent * for the control group: sclap inflammatory disease active the day of the examination

Keywords: trichoscopy dermoscopy systemic scleroderma scalp
ultrasound evaluation of gastric emptying in diabetic patients: a comparison with non-diabetic controls

Conditions: Diabetes Mellitus

Summary: this is a prospective cohort study. the main objective is to compare the prevalence of a "full stomach" using gastric ultrasound technique, in elective surgical patients with diabetes mellitus compared to non-diabetic controls following the present fasting guidelines (2 h after clear liquid and 6h after a light meal). for patients with a full stomach or intermediate stomach, an consecutive ultrasound scan is performed every 10 min,until empty stomachstomach contents are detected to determine the mean gastric emptying time for clear liquid and light meal, and to investigate the risk factors for delayed stomach emptying in diabetic patients by logistic regression analysis .


Eligibility criteria:
inclusion criteria: * diabetes (two fasting plasma glucose concentration≥7mmol/l or casual plasma glucose concentration≥11.1mmol/l); * age≥18 yr; asa physical status i-iii; * body mass index \<35kg/m2; * who are admitted to the surgical department; * who are able to understand the rationale of the study and provide informed consent. exclusion criteria: * pregnancy; * a history of upper gastrointestinal disease or previous surgery on the oesophagus, stomach or upper abdomen; * documented abnormalities of the upper gastrointestinal tract such as gastric tumors; * recent upper gastrointestinal bleeding (within the preceding 1 month); * taking medicines that may delay gastric emptying(e.g., anticholinergic agents). * hypothyroidism.
efficacy of ultrasound guided pifb versus lidocaine infusion on postoperative pain after thoracotomy

Conditions: Cardiac Surgery

Summary: chronic pain is a common complication after cardiothoracic surgery. the prevalence of post-thoracotomy pain syndrome (ptps) ranges from 33% to 91%. exact pathogenetic mechanisms for developing chronic pain after thoracotomy are unknown. apart from intraoperative nerve damage and subsequent postoperative neuropathic pain, operation techniques, age, sex, pre-existing pain, genetic and psychosocial factors, severe postoperative pain, and analgesic management are suspected to have an impact on the development of ptps .

ultrasound-guided pecto-intercostal fascial block (pifb) has been advocated by some researchers for cardiac surgery. pecto-intercostal fascial plane block (pifb) is a novel, minimally invasive, regional fascial plane block technique. pifb was first described by de la torre in patients undergoing breast surgery . pifb targets the anterior intercostal nerves as they run in the fascial plane between the pectoral and the intercostal muscles and emerge on either side of the sternum. also, lidocaine, a short-acting local anesthetic, has been proved to have analgesic and anti-inflammatory effects . the application of lidocaine by continuous infusion in the intraoperative period and immediately after the surgery appears to reduce the immediate postoperative pain, and may prevent the ptps

Eligibility criteria:
inclusion criteria: 1. age between 18 and 75 years. 2. patient scheduled to undergo elective on-pump cardiac surgery with sternotomy. 3. american society of anesthesiologists classification of physical status \< iv. exclusion criteria: 1. emergency surgery. 2. off-pump surgery. 3. redo surgery. 4. ejection fraction less than 35%. 5. refusal of the patient. 6. known hypersensitivity to la. 7. chronic opioid use or chronic pain patient. 8. psychiatric problems or communication difficulties. 9. liver insufficiency (defined as a serum bilirubin ≥ 34 μmol/l, albumin ≤ 35 g/dl, inr ≥ 1.7). 10. renal insufficiency (defined as a glomerular filtration rate \< 44 ml/min). 11. obstructive sleep apnea syndrom. 12. coexisting hematologic disorders. 13. pregnancy or breastfeeding.
a study of atezolizumab in patients with unresectable, locally advanced or metastatic nsclc (j-tail)

Conditions: Non-small-Cell Lung Cancer

Summary: this prospective, observational study is to assess the long-term effectiveness and safety of atezolizumab in patients with advanced non-small cell lung cancer in clinical practice.

primary endpoint: 18 months os, secondary endpoints: overall survival(os), 12 months survival rate(12mo os), 24 months survival rate(24mo os), progression-free survival(pfs), time to treatment failure (ttf), objective response rate(orr), disease control rate(dcr), duration of response(dor) ,safety and euroqol 5-dimension 5-level (eq-5d-5l) questionnaire

Eligibility criteria:
inclusion criteria: * patients 20 years of age or older at the time of signed consent. * patients with locally advanced or metastatic non-small cell lung cancer. * patients who are scheduled to start atezolizumab monotherapy, based on the atezolizumab package insert and the optimal use promotion guideline. * patients who signed informed consent form before enrolling the study. the consent from a legally acceptable representative is required for the patients with uncertain capacity of judgments. exclusion criteria: * patients who are considered to be unsuitable for enrolment into the study by the investigator's judgment.

Keywords: atezolizumab
angle specific torque profiles after distal radius fracture

Conditions: Radius Distal Fracture

Summary: distal radius fracture (drf) is one of the most common upper extremity injuries and can lead to long-term kinesiological and anatomical alterations despite proper surgical fixation and rehabilitation. this retrospective cohort study aims to analyze the angle-specific torque characteristics of wrist (flexion/extension), forearm (supination/pronation), and elbow (flexion/extension) movements in patients with a history of drf treated by volar plate fixation. the study will utilize archived raw data of 37 eligible patients who underwent isokinetic strength testing during the post-rehabilitation period. data will be extracted from cybex norm® and humac isokinetic dynamometer systems and analyzed using statistical parametric mapping (spm) with the open-source spm1d package in matlab. this analysis will generate 101-point angle-dependent torque curves for each joint movement and will be used to evaluate interlimb asymmetry, angle of peak torque production, and unilateral agonist/antagonist torque ratios. additionally, radiographic images archived during the treatment period will be analyzed to measure radial inclination, palmar tilt, and ulnar variance using the dresdner scoring system. the torque profiles and radiological parameters will be statistically analyzed with spss. between-limb comparisons and symmetry indices will be calculated using repeated-measures anova, t-tests or non-parametric alternatives, depending on data distribution. this research is expected to provide new insights into the kinesiological consequences of drf by presenting detailed angle-specific torque characteristics, going beyond conventional peak torque and range of motion assessments commonly seen in the literature.


Eligibility criteria:
inclusion criteria: * patients with distal radius fractures reduced with a volar plate will be included. exclusion criteria: * patients with bilateral injuries, fractures in bones other than the radius, stabilization methods other than volar plate, and any other neurological or orthopedic condition that may affect the evaluation will be excluded from the study.
tailored intervention to promote positive airway pressure adherence

Conditions: Sleep Apnea, Obstructive; Patient Compliance

Summary: the purpose of this study is to examine the feasibility of a tailored (i.e., individualized) intervention to promote adherence to continuous positive airway pressure therapy (cpap) in adults with newly-diagnosed, cpap treated, obstructive sleep apnea.

poor adherence to cpap is a significant problem among osa patients resulting in suboptimal health and functional outcomes. intervention studies to promote cpap adherence have shown relatively small effects in selected samples and were costly. the overall objective of this research is to examine the effect, feasibility, and acceptability of a tailored intervention on cpap adherence among adults with newly-diagnosed, cpap treated osa. the central hypothesis is that critically timed tailored interventions that focus on sociocultural aspects and cognitive perceptions of the individual experience with osa diagnosis and treatment will improve overall cpap adherence rates. the pilot randomized controlled trial will examine cpap adherence outcomes at 1wk, 1mo, and 3mo among those randomly assigned to the tailored intervention or usual (standard) care and examine specific feasibility and participant acceptability outcomes in order to design and conduct a subsequent larger randomized controlled trial testing the overall efficacy of the tailored intervention.

Eligibility criteria:
inclusion criteria: * males and females \>/= 18 years of age * newly diagnosed with apnea/hypopnea index \>/= 10 events/hr * cpap naive * able to read and speak english exclusion criteria: * previous diagnosis and/or treatment of osa * major new psychiatric diagnosis within 6 months of study enrollment * require supplemental oxygen or bilevel positive airway pressure on cpap titration polysomnogram * diagnosis of co-existent sleep disorder on polysomnogram, including periodic limb movements \>/= 10 events/hr with arousal, central sleep apnea with \>/= 5 central events/hr, insomnia, sleep hypoventilation syndrome, or narcolepsy

Keywords: social support cognition adaptation, psychological health behavior patient education
the mitopure challenge to detect levels of urolithin a in dried blood spots

Conditions: Healthy Aging; Healthy; Healthy Diet

Summary: open labelled, virtual home based study to assess the test repeatability and the failure/rejection rate of the samples collected at home by participants.


Eligibility criteria:
inclusion criteria: 1. males and females 18 to 80 years of age; 2. is in general good health, as determined by the research team; 3. willingness to consume the investigation product, complete questionnaires and to complete the study; 4. have given voluntary, electronic, informed consent to be a participant in the study. exclusion criteria: 1. women who are pregnant, breastfeeding, or planning to become pregnant during the course of the trial; 2. volunteers who plan to donate blood during the study or within 30 days of completing the study; 3. subject has a known allergy to the test material's active or inactive ingredients; 4. subjects with unstable medical conditions; 5. participation in a clinical research trial within 30 days prior to randomization; 6. allergy or sensitivity to study ingredients; 7. individuals who are cognitively impaired and/or who are unable to give informed consent; 8. any other condition which in the investigator's opinion may adversely affect the subject's ability to complete the study or its measures or which may pose significant risk to the subject; 9. has taken antibiotics within the previous 30 days.
evaluation of rex-c system in measurement and improvement of patients' adherence.

Conditions: Thromboembolism

Summary: the study aims to evaluate the safety, usability and efficacy of the rex-c - a novel medication management system - in measurement and improvement of adherence, in patients receiving oral anti-coagulation therapy for the treatment and prevention of thromboembolism.

rex-c is a mobile system intended to provide solid, oral medication on patient demand, according to a pre-programmed treatment protocol. rex-c addresses poor adherence to medication therapy by providing real-time, reliable adherence data to caregivers and timely, personalized reminders to patients. during the study, the use of rex-c system to receive medications will be compared to standard of care. patients' adherence will be evaluated for both methods.

Eligibility criteria:
inclusion criteria: 1. male or female, at least 18 years of age 2. subject is able to swallow pills and use rex-c device to receive medication. 3. subject is able to read and understand the informed consent form. 4. subject receives anti-coagulants for the treatment and prevention of thromboembolism events, (e.g: arterial fibrillation (af), deep vein thrombosis (dvt) or pulmonary embolism (pe)). 5. subject receives novel oral anti-coagulant (noac); including; pradaxa® (dabigatran), xarelto® (rivaroxaban) and eliquis® (apixaban). 1. subject is recruited at least 1 month after treatment initiation and has stable dose regime. 2. subject receives stable dose of medication for at least a month. 6. subject takes medication therapy at home. exclusion criteria: 1. subject has significant physical disability including; poor fine motor skills, impaired visual or auditory faculties, mental disorders or other impairment affecting ability to provide informed consent form or use the rex-c dispensing unit effectively. 2. subject cen not use rex-c to receive medications. 3. subject is participating in another clinical study that does not permit participation in two studies simultaneously. 4. subject is at end stage or terminal illness with anticipated life expectancy of 6 months or less. -
efficacy of noshintrial in diabetic patients

Conditions: Diabetes Mellitus, Type 2; Insulin Resistance

Summary: the goal of this \[efficacy of a traditional anti-diabetic herbal drug with on glycemic, inflammatory, and oxidative stress parameters\] is \[investigate the level of homa-estimated insulin resistance as the primary outcome before and after 40 days in intervention and placebo groups\] in \[patients with type 2 diabetes\]. the secondary outcomes of this study are the assessment of oxidative stress, inflammation biomarkers, other glycemic indices, hematopoietic status and lipid profile between the two groups before and after the intervention. also the food frequency questionnaire (ffq) and the physical activity questionnaire (faq) are used to evaluate the effect of potential confounding factors. this study has the code of ethics ir.kmu.rec.1402.291 from kerman university of medical sciences and this drug has the number 12/14484 from iran food and drug administration (ifda).

all the volunteers (diabetic men and women with hba1c more than 6.5 from the age of 20 to 65 years who usually use their standard medicine) who meet the entry criteria were directed to the laboratory and imaging center so that biochemical tests can be performed on them before taking the drug. volunteers are asked to take the received medicine three times a day after food. it is worth mentioning that the patients will be divided into two groups by a person outside the research team, one group will drink herbal syrup and the other group will receive a placebo. a placebo with the same appearance as herbal syrup will drink nectar. on a weekly basis, the researcher will make phone calls with the applicants and, while reminding and recording the amount of herbal syrup consumed by drinking nectar, will also ask about the possible side effects of consuming herbal syrup drinking nectar. then, at the end of the six week, the patient was asked to visit the clinic for a final evaluation. in this stage, the patient is asked about possible side effects, and the last stage of sample collection will be done to review all the tests of the next stage of receiving the drug (biochemical tests). return at the end of week 6. the sample size in this study is 70 people.

Eligibility criteria:
inclusion criteria: 1. age between 20 and 65 years 2. hba1c more than 6.5 3. consistency of diet and exercise program 4. body mass index less than 35 5. not receiving insulin 6. the patient should take standard medicine except insulin exclusion criteria: 1. performing cabg surgery, occurrence of asc, heart and brain stroke, pulmonary embolism, deep vein thrombosis or tia in the last 1 year. 2. taking anti-inflammatory drugs such as aspirin with an anti-inflammatory dose, antioxidant supplements, vitamins and omega-3 capsules (\<1 g/day), and immunosuppressive drugs in the last three months. 3. presence of cancer, liver and thyroid diseases. 4. pregnancy 5. smoking and alcohol consumption

Keywords: type 2 diabetes mellitus insulin
effect of steroid injection which is added to percutaneous trigger finger release: a double-blinded randomized controlled trial.

Conditions: Trigger Finger

Summary: background present treatment strategies for trigger finger when conservative management including steroid injection was failed include percutaneous or open a1 pulley release, but some people showed prolonged swelling and delay of complete healing. we aimed to test the hypothesis that an improved outcome can be achieved by employing steroid injection simultaneously with percutaneous release compared with conventional percutaneous release alone methods we designed a double-blind, randomized controlled trial. inclusion criteria is the patient who has symptom of trigger finger warranted surgical release after sufficient time of conservative treatment. exclusion criteria are as follow: 1) multiple fingers at presentation; 2) rheumatoid arthritis patients; 3) pregnant or lactating patients; 4) younger than 18 years old; 5) previous surgery history of finger 6); the patients who got steroid injection more than 4 time previously; 7) coagulation abnormality including usage of anti-thrombotic agent. after power analysis by a statistician, total 40 patients would be required for each group (percutaneous alone group versus percutaneous alone + steroid injection group). the surgery will be performed by outpatients clinic basis with local injection. additional steroid injection will be given to half of patients after allocation with randomized selection by permutaed block randomization. primary outcome measure is mean fall in pain visual analogue scale (pvas) and secondary outcome will be proportion of patients with good response (defined as "perfect" or "much better" as reported by patients). follow-up will be conducted 3 weeks and 3 month after index procedure


Eligibility criteria:
inclusion criteria: * trigger finger patients who require surgical intervention due to failuer of sufficient time of conservative treatment exclusion criteria: * age under 18 years old * rheumatoid arthritis patients * patients who got steroid injection more than 4 times previously * multiple finger affected at presentation * previous surgery history * any recent trauma history of affected hand
comparison of two methods for bowel preparation in patients with constipation

Conditions: Health Behavior

Summary: constipation is a common high risk factor for inadequate bowel preparation. the bowel cleansing efficacy of the standard split-does of 4l seems to be suboptimal in constipated patients. the investigator hypothesized that compared with the standard preparation regime, the split-dose with three times of 4l peg may be superior in bp quality.


Eligibility criteria:
inclusion criteria: * patients aged 18-80 with constipation. exclusion criteria: * history of colorectal surgery bmi\>30 suspected colonic stricture or bowel obstruction use of purgatives within 3 days pregnancy or lactation unable to give informed consent haemodynamically unstable

Keywords: peg bowel preparation colonoscopy split-does