Kornimate/medical-research-clean huggingface dataset:
mesenteric sparing versus central mesenterectomy in ileocolic resection for terminal ileitis in crohn's disease

Conditions: Crohn's Disease

Summary: the aim of this multicenter randomised controlled trial is to analyse the six month endoscopic recurrence following a mesenteric sparing versus a central mesenterectomy performing an ileocolic resection for cd.

there is emerging evidence to suggest that crohn's disease (cd) may be a disease of the mesentery rather than just of the bowel alone. a more extensive central mesenterectomy (up to the level of the ileocolic artery), in order to remove an increased volume of affected mesentery to prevent postoperative cd, has been suggested to lead to beneficial results. it is hypothesised that patients who undergo a central mesenterectomy during an ileocolic resection compared to a mesenteric sparing ileocolic resection will have decreased recurrence rates.

Eligibility criteria:
inclusion criteria: in order to be eligible to participate in this study, a subject must meet all of the following criteria: 1. ileocolic disease with an indication for ileocecal resection 2. concurrent therapies with corticosteroids, 5-asa drugs, thiopurines, mtx, antibiotics, and anti-tnf therapy are permitted. 3. all patients should have undergone a colonoscopy and mr enterography (or ct enterography if mr contraindicated) in last 3 months to assess extent of disease. 4. ability to comply with protocol. 5. competent and able to provide written informed consent. 6. patient must have been discussed in the local mdt exclusion criteria: a potential subject who meets any of the following criteria will be excluded from participation in this study: 1. inability to give informed consent. 2. patients less than 16 years of age. 3. patients undergoing repeated ileocolic resection. 4. clinically significant medical conditions within the six months before the operation : e.g. myocardial infarction, active angina, congestive heart failure or other conditions that would, in the opinion of the investigators, compromise the safety of the patient. 5. history of cancer \< 5 years which might influence patients prognosis 6. emergent operation. 7. pregnant or breast feeding. 8. inability to follow up at 3, 6 and 12 months for postoperative assessment, imaging and endoscopy.

Keywords: crohn's disease ileocolic mesenteric sparing extended mesenterectomy
ultherapy™ treatment following sculptra® treatment

Conditions: Skin Laxity

Summary: this clinical trial will evaluate clinical outcomes associated with the non-invasive ultherapy™ treatment to improve skin laxity and tightening following a sculptra® treatment.

this study is a prospective,single-center, randomized clinical trial. up to thirty (30) subjects will be treated. enrolled subjects will be assigned to one of three (3) groups. up to 10 subjects per group.

Eligibility criteria:
inclusion criteria: * male or female, aged 35 to 60 years. * subject in good health. * skin laxity in the lower face and neck. * grade 1 and 2 on the knize scale exclusion criteria: * presence of an active systemic or local skin disease that may affect wound healing. * severe solar elastosis. * excessive subcutaneous fat in the face and neck. * excessive skin laxity on the face and neck. * no scarring in areas to be treated. * any open facial wounds or lesions. * acne on the face. * patients who have a history with keloid formation or hypertropic scarring * patients who have a hypersensitivity to injectable poly-l-lactic acid * presence of a metal stent or implant in the facial area to be treated.

Keywords: ulthera® system ultherapy™ treatment ulthera, inc. ultrasound treatment for skin tightening skin laxity on the face and neck.
transplantation of faeces in ulcerative colitis; restoring nature's homeostasis

Conditions: Ulcerative Colitis

Summary: ulcerative colitis (uc) is a chronic inflammatory bowel disease (ibd) of the colon. complaints such as abdominal pain, cramps and bloody diarrhoea usually start in early adulthood and lead to life-long substantial morbidity. there is no medical treatment available that meets the desired criteria of high efficacy versus low adverse effects. the current prevailing hypothesis regarding the cause of uc states that the pathogenesis involves an inappropriate and ongoing activation of the mucosal immune system driven by the intestinal microbiota in a genetically predisposed individual. systematic investigation into the effect of correcting the dysbiosis in ulcerative colitis patients has never been performed. the most radical way to restore the presumably disturbed natural homeostasis in uc is to perform faecal transplantation from a healthy donor. in this trial the potential beneficial effects of restoring microbial homeostasis by faecal transplantation through a duodenal tube will be studied in a phase ii randomised placebo controlled design. endpoints are clinical remission and reduction of endoscopic inflammation after 12 weeks (primary), as well as time to recurrence, intra individual changes in faecal samples and mucosal biopsies. follow up is 12 months.

treatment with faecal transplantation from a healthy donor in active ulcerative colitis patients. in this trial the potential beneficial effects of restoring microbial homeostasis by faecal transplantation through a duodenal tube will be studied in a phase ii randomised placebo controlled design.

Eligibility criteria:
inclusion criteria: * age ≥ 18 * ability to give informed consent * established ulcerative colitis with known involvement of the left colon according to the lennard-jones criteria * sccai of 4 \> \< 11 * endoscopic mayo score of \> 1 * stable dose of thiopurines in preceding 8 weeks * stable dose of corticosteroids and 5-asa in preceding 2 weeks exclusion criteria: * condition leading to profound immunosuppression * anti-tnf treatment in preceding 2 months * cyclosporine treatment in preceding 4 weeks * use of methotrexate in preceding 2 months * prednisolone dose \> 10 mg * life expectancy \< 12 months * use of systemic antibiotics in preceding 6 weeks * use of probiotic treatment in preceding 6 weeks * positive stool cultures for common enteric pathogens (salmonella, shigella, yersinia, campylobacter, enteropathogenic e coli) * positive faecal pcr-test (positive pcr means: \> 1 of the following viruses is present) for: rotavirus, norovirus, enterovirus, parechovirus sapovirus, adenovirus 40/41/52. astrovirus. * pregnancy or women who give breastfeeding * vasopressive medication, icu stay

Keywords: faecal transplantation ulcerative colitis inflammatory bowel disease
clinical performance of short fiber reinforced flowable resin composite restorations 2y rct

Conditions: Decay, Dental; Caries Class II

Summary: clinical performance of short fiber reinforced flowable resin composite restorations versus conventional resin composite restorations will be tested in posterior teeth (2y randomized clinical trial).


Eligibility criteria:
inclusion criteria: * patients with large proximal carious cavities in molars. * pulp asymptomatic vital carious upper or lower molars. * good oral hygiene. exclusion criteria: * presence of signs and symptoms of irreversible pulpitis or pulp necrosis * severe medical complications. * allergic history concerning methacrylates * evidence of parafunctional habits.

Keywords: short fiber reinforced flowable resin composite clinical performance ever x flow randomized clinical study
fourth dose of mrna covid-19 vaccine in residents of ltcfs

Conditions: SARS-CoV2 Infection; Coronavirus Infection

Summary: this study is a multi-centre, blinded, randomized controlled trial. ltcf residents ≥ 65 years who have received three doses of mrna vaccine will be randomized to vaccination with a fourth dose of pfizer-biontech mrna- covid-19 vaccine or to vaccination with a control (prevnar-13 vaccine).

the primary objective of this study is to test whether vaccinating ltcf residents ≥65 years with a fourth dose of pfizer-biontech mrna- covid-19 vaccine as compared to control (pcv13) leads to an increase in detectable neutralizing antibodies. participants will be randomized to receive either the pfizer covid-19 vaccine or the pnemoccocal prevnar-13 vaccine at baseline after bloodwork is drawn. another blood sample will be taken 28 days later. after completion of the study, participants in the control group (pneumococcal prevnar-13 vaccine) will be given a fourth dose of mrna covid-19 vaccine and will have their blood drawn 28 days post-vaccination.

Eligibility criteria:
inclusion criteria: * ltcf residents ≥ 65 years who have received three doses of mrna vaccine. exclusion criteria: * immunocompromised individuals due to known or suspected immunodeficiency or due to receipt of immunosuppressive medication (e.g., steroids, biologics). * having had a severe adverse reaction (e.g., anaphylactic allergy) to mrna or pneumococcal vaccine. * having received pneumococcal polysaccharide vaccine within 12 months. * ltcf residents who have an interval less than 3 months from their third mrna covid vaccine dose.

Keywords: covid-19 immunization long-term care
effects of circuit training combining different types of distal robot-assisted and task-oriented therapy on motor control, motor and daily functions, and quality of life after stroke

Conditions: Stroke Patients

Summary: this study proposes a novel stroke rehabilitation approach for upper extremity training by firstly combining different types of distal robot-assisted and task-oriented therapy in a circuit training program. the program could enhance ue functions, improving daily function, decrease caregiver burden and lower medical expenses associated with long-term care. professionals can use these findings to promote the application of clinically empirical research and better understand the effects and mechanisms of circuit training.


Eligibility criteria:
inclusion criteria: 1. unilateral stroke ≥ 3 months onset 2. fugl-meyer assessment for upper extremity (fma-ue) score between 18 to 56, indicating different levels of motor impairments ; 3. without excessive spasticity in any of the ue joint (modified ashworth scale ≤3 in proximal joints and modified ashworth scale ≤2 in distal joints); 4. mini mental state exam (mmse) score \> 24, indicating no serious cognitive impairment; 5. between the ages of 20 and 75 years - exclusion criteria: 1. histories of other neurological diseases such as dementia, parkinson's disease, and peripheral polyneuropathy; 2. difficulties in following and understanding instructions such as global aphasia; 3. enroll in other rehabilitation or drug studies simultaneously; 4. receiving botulinum toxin injections within 3 months. -

Keywords: stroke rehabilitation distal upper extremity
study evaluating sumanirole for the treatment of the signs and symptoms of early parkinson's disease

Conditions: Parkinson Disease

Summary: the primary purpose of this study is to determine whether sumanirole, at three different dose levels, is effective and safe in the treatment of the signs and symptoms of early parkinson's disease


Eligibility criteria:
inclusion criteria: idiopathic parkinson's disease \< 7 years duration modified hoehn and yahr scale stages i through iii age greater than or equal to 30 years old patients or their partners must use adequate contraceptive methods patients who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures and do not plan on traveling extensively during the study exclusion criteria: atypical parkinson's disease syndromes due to drugs, metabolic disorders, encephalitis, or degenerative diseases. levodopa received for 1-year accumulated interval in the last two years. dopamine agonist medications or catechol-o-methyl transferase inhibitors in the 30 days prior to baseline. unstable dose regimes of hypnotics, anxiolytics or antidepressants dementia history of stereotaxic brain surgery, psychosis or active epilepsy within past year. participation in clinical trial within the previous 30 days. malignant melanoma or history of melanoma significant medical or pshychiatric condition
prismatic adaptation for rehabilitation of postural imbalance after stroke

Conditions: Chronic Right Supratensorial Stroke Patients

Summary: postural imbalance after stroke leads to limitations of activity and a worse autonomy. the postural imbalance is increased in right supratensorial stroke (rss) compared to left supratensorial stroke. the evidences for the rehabilitation of postural imbalance are weak. likewise, disorders of spatial reference frames are increased in rss. the postural imbalance is correlated with the disorders of spatial reference frames in rss patients. prismatic adaptation (pa) is often used for the rehabilitation of unilateral spatial neglect after rss. several studies have demonstrated a peculiar expansion of sensorimotor after-effects to spatial cognition. an immediate effect of reduction in postural imbalance have been showed in acute rss. therefore, it is interested to investigate the immediate and delayed effects of pa on the postural balance and the spatial reference frames in chronic rss to purpose a new therapeutic approach. the hypothesis of the study is that pa would improve the postural balance (activity) of chronic rss patients by a reduction in mediolateral postural asymmetry, resulting from a " bottom-up " action of pa on spatial reference frames.


Eligibility criteria:
inclusion criteria: * adult, over 18 years old, and less than 80 years old * stroke * right * supratensorial, * unilateral, * haemorrhagic or ischemic, * chronic (over 12 months) * ability to stay over 30 seconds in standing static position with open eyes and close eyes * show a postural imbalance, determined by a body weight bearing on right lower limb ≥ 60% during at least one posturographic evaluation with open eyes and that requires an inpatient rehabilitation * covered by a health system where applicable, and/or in compliance with the recommendations of the national laws in force relating to biomedical research * free, enlightened and written consent of the patient exclusion criteria: * cerebellar lesion * brainstem lesion * bilateral cerebral lesion * all orthopaedic or rheumatologic diseases, retinal visual impairments or other diseases interfering with assessments in accordance with the investigator's judgment * pregnancy or breast feeding * under an administrative or legal supervision

Keywords: stroke hemiplegia rehabilitation prismatic adaptation postural imbalance posture spatial cognition
levels of circulating t cells expressing vla-1 collagen receptors

Conditions: Ischemic Heart Disease

Summary: the examination of the percentage of peripheral t cells carrying vla-1 in ischemic heart disease patients. the hypothesis is that the percentage levels of cells carrying this integrin rise according to the severity of the ischemic heart disease.

atherosclerosis is considered an inflammatory disease in which lymphocytes have an important role. the study was disigned to find out the changes in t cell levels carrying vla-1 involvement in this process.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of acute mi for group 1 * clinical diagnosis of acsl for group 2 * clinical diagnosis of chronic heart disease for groups 3 and 4 * chest pain but normal heart scan for group 5 exclusion criteria: * none
prone position impact in ards patients on the incidence of central venous catheter colonization

Conditions: ARDS, Human; Catheter Infection

Summary: catheter colonization, catheter-associated infection and catheter-associated bacteremia are a major challenge for resuscitation unit. this study wishes to explore the impact of the central venous catheter colonization on the ards patient with and without prone position.

catheter-associated infection prevention is achieved by identification of the population at risk. patients receiving prone position under acute respiratory distress syndrome appear to be particularly vulnerable. this retrospective study is designed to compare the risk of catheter colonization that could be induced or worsened by prone position. knowing that, prone position is increased into the care acute respiratory distress syndrome since few years. unfortunately, no study has examined the prone position impact on catheter-association infection in these population.

Eligibility criteria:
inclusion criteria: * hospitalized patient in the reanimation unit of the chr metz-thionville or the chru nancy between january 2014 and december 2015 * patient with an acute respiratory distress syndrome, moderate or severe * with a central venous catheter * with or without prone position during the stay exclusion criteria: * minor patient * absence of information on central venous catheter bacteriology
pulmonary rehabilitation in post-acute period of covid-19 infection

Conditions: COVID-19

Summary: the aim of this study is to investigate the efficacy of pulmonary rehabilitation(pr) applied in the isolation processes of post-acute patients with mild and moderate symptoms who had positive covid-19 test on dyspnea,muscle pain,chest expansion,lower limb muscle strength and dynamic balance,fatigue,anxiety and depression.

this study was conducted with 270 patients who were the covid-19 test was positive and isolated in their homes during post-acute periods.while one of the groups (n=135) was asked to remain isolated at home by providing patient education,a pr program was applied for 4 weeks in addition to the patients in the other group(n=135).pr consists of patient education, breathing, in-house mobilization and range of motion exercises.as the evaluation parameters,pre-treatment and post-treatment dyspnea levels with borg scale,muscle pain with visual analog scale(vas),functional capacities with sit-up test,chest expansions with tape measure,respiratory frequency,fatigue level with fatigue severity scale,and emotional status with hospital anxiety and depression(had) scale were evaluated.

Eligibility criteria:
inclusion criteria: * between the ages of 28-45, positive covid-19 test, being in the post-acute period, having symptoms of mild-moderate severity, respiratory rate ≤40 breaths / min, patients who can make video speech exclusion criteria: * severe symptom involvement, fever more than 38 degrees, obese patients, patients with multiple comorbidities, patients with one or more organ failure, oxygen saturation in the blood ≤95%, a resting blood pressure of \ 140 / 90 mmhg patients

Keywords: pulmonary rehabilitation dyspnea fatigue pain anxiety
incidence of parkinson's disease among veterans

Conditions: Parkinson's Disease

Summary: this is a database study. medical records will be reviewed in order to document a new or pending diagnosis of parkinson's disease and in order to learn more about the disease process. other than the time that it takes to complete a medical record authorization form, no other human subject participation will be needed.


Eligibility criteria:
chart review
assessment of corneal endothelium after collagen cross linking

Conditions: Accelerated Corneal Collagen Cross Linking

Summary: the aim of this study is to assess the effect of accelerated corneal collagen cross linking on corneal endothelium using the specular microscopy

keratoconus (kc) is a progressive, non-inflammatory corneal degenerative disease. it is a pathology characterized by a progressive thinning and protrusion of the cornea that ends in a cone-shaped cornea. this results in progressive myopia and irregular astigmatism with associated progressive loss of vision and thus reduced quality of life.collagen cross-linking (cxl) is a relatively new conservative approach for progressive corneal ectasia. the main indication for cxl is to slow the progression of corneal ectatic diseases, such as keratoconus, pellucid marginal degeneration (pmd), keratoglobus and iatrogenic ectasia.the basic principle of this method is the chemical interaction of ultraviolet a radiation (315-400nm ) and riboflavin to induce covalent bond formation between collagen fibers of the cornea. in this way, the stiffness and rigidity of the cornea are provided.corneal collagen cross-linking (cxl) was first introduced by wollensak with an ultraviolet-a (uva) protocol of 3 medium wave mw/cm2 intensity at 370 nm over an exposure time of 30 minutes (now termed the "dresden protocol"). researchers have proposed accelerated cxl (acxl) protocols, to improve convenience and comfort for patients. these acxl protocols have the aim of decreasing uva exposure time by increasing uva fluency to achieve the same overall total uva dosage.despite corneal cxl is a safe and effective procedure with few known side effects .persistent corneal edema and possible endothelial cell damage have been reported in a few cases after cxl. based on the extent of endothelial damage, patients may require penetrating keratoplasty.

Eligibility criteria:
inclusion criteria: 1. patients with mild to moderate corneal ectasia who are candidates for cxl. exclusion criteria: 1. patients with advanced corneal ectasia with maximum keratometry readings \<56 diopters. 2. corneal pachymetry \>380um. 3. corneal scarring. 4. previous corneal surgeries (e.g intrastromal corneal ring segments)
clinical outcome following early decannulation of severe acquired brain injury patients

Conditions: Brain Injuries

Summary: after severe acquired brain injury (sabi: severe traumatic brain injury, stroke, anoxic brain damage), up to 50-70% of patients are tracheostomized. the need to tracheostomize a patient is based on the prolonged inability to breathe and/or protect their airway sufficiently. this is usually done in an intensive care unit (icu). a tracheostomy is first removed when the patient's clinical conditions allow for it. the removal can be performed in many settings, a neurological rehabilitation unit being one of these. the overall objective of this study is to evaluate the safety of this earlier decannulation procedure in patients with sabi at our department as well as the effectiveness on functional ability.


Eligibility criteria:
inclusion criteria: all severe acquired brain injury patients ≥ 18 years with a tracheal tube at admission. exclusion criteria: -
wireless capsule endoscopy in small-bowel crohn's disease

Conditions: Crohn's Disease

Summary: the purpose of this study is to determine the best role for capsule endoscopy in diagnosing crohn's disease.

wireless capsule endoscopy (ce) is a food and drug administration (fda) approved technology that allows viewing of the entire small-bowel. capsule endoscopy involves swallowing a pill-sized camera that sends images to a data recorder worn on a vest. because crohn's disease (cd) often involves the small bowel, we would like to find out if capsule endoscopy is useful in diagnosing small-bowel crohn's disease. current methods for diagnosing small-bowel crohn's disease include colonoscopy, esophagogastroduodenoscopy (egd), enteroscopy (ent), single contrast barium small-bowel follow through (sbft), and double contrast small-bowel enteroclysis (sbe), but these tests are unable to identify the presence or extent of small-bowel disease in many patients.

Eligibility criteria:
inclusion criteria: * english speaking adult patients (\>18 years old) with known crohn's disease exclusion criteria: * severe medical or psychiatric co-morbidities * active swallowing problems * bowel obstruction * history of stricture or fistula * pregnancy * taking aspirin/non-steroidal anti-inflammatory drug (nsaid) or potassium chloride (kcl) within 4 weeks prior to the colonoscopy and anytime after colonoscopy * inability to consent * exclusion of patients whose colonoscopy was done for reasons other than signs/symptoms suggestive of crohn's disease

Keywords: capsule endoscopy in small bowel