Kornimate/medical-research-clean huggingface dataset:
effect of ivabradine in lowering heart rate and quality of life in chronic heart failure patients

Conditions: Chronic Heart Failure

Summary: elevated heart rate (hr) (≥ 70 bpm) is one of the contributing factors in increasing the burden of hospitalization among heart failure patient. ivabradine is a novel, selective and specific in inhibiting a funny current in sinoatrial node node and approved as an alternative therapy for chronic heart failure (chf) patients. chf patients when treated with ivabradine reported 39%, and 30% reduction in mortality and hospitalization rate respectively. patient were treated with ivabradine 5mg twice daily to determine its effect in lowering heart rate and the quality of life (qol) in chronic heart failure patients

a prospective, post-marketing observational study was conducted in 50 chronic heart failure patients with age 30-70yrs of nyha class ii and prescribed 5 mg ivabradine twice daily. heart rate was evaluated through ecg \& quality of life was measured by a validated questionnaire euroqol-5 dimension 3 level version (eq-5d-3l). baseline demographic includes age, gender, height, weight, body mass index, temperature, blood pressure and respiratory rate were recorded and patients were followed at week 4 and week 8. safety and tolerability was assessed by adverse drug reaction (adr) monitoring. results were analyzed by statistical software spss version 20.0.

Eligibility criteria:
inclusion criteria: * written informed consent * known case of chronic heart failure (new york heart association (nyha) functional class ii to iii) * clinically stability (at least for 4 weeks) * resting heart rate of more than 70 beats/ min (bpm) as assessed from the 12-lead electrocardiogram. exclusion criteria: * hypersensitivity to the active substance or to any of the excipients * resting heart rate below 70 beats per minute prior to treatment * cardiogenic shock * acute myocardial infarction * severe hypotension (\< 90/50 mmhg) * severe hepatic insufficiency * sick sinus syndrome * sino-atrial block * unstable or acute heart failure * pacemaker dependent (heart rate imposed exclusively by the pacemaker) * unstable angina * atrioventricular block of 3rd degree * the combination with a strong cytochrome p450 3a4 inhibitors such as azole antifungals (ketoconazole, itraconazole), macrolide antibiotics (clarithromycin, erythromycin, telithromycin), hiv protease inhibitors (nelfinavir, ritonavir) and nefazodone * the combination with verapamil or diltiazem which are moderate cyp3a4 inhibitors with heart rate reducing properties. * pregnancy, lactation and women of child-bearing potential not using appropriate contraceptive measures

Keywords: ivabradine heart rate health related quality of life safety chronic heart failure patient
tampa kinesiophobia scale modified for headache

Conditions: Migraine; Tension-type Headache; Cervicogenic Headache

Summary: tampa kinesiophobia scale is a scale that has been validated and reliable in individuals with low back pain in the turkish population and evaluates fear of movement due to the risk of triggering pain. especially for migraine headache, patients have complaints about movement and fear of movement, and in addition, according to the international classification of headache disorders, 3rd edition criteria, the item of aggravation with physical activity is considered as a diagnostic criterion. migraine patients may theoretically start their attacks due to hypocretin neuropeptide and lactate metabolism dysfunction. it has been stated that calcitonin gene-related peptide (cgrp), which is released during migraine attacks, is also released during exercise and intense physical activity and can trigger attacks. therefore, patients avoid physical activity and exercise. it has been stated that movements that do not require effort can also trigger attacks in migraine patients, but this is not seen in tension-type headache. cervicogenic headache is also a less researched topic in general, and there is not enough data on kinesiophobia in this area. the aim of this study is to investigate the validity and reliability of the tampa kinesiophobia scale for headache in patients with migraine, tension-type and cervicogenic headaches for the turkish population. the potential relationships between the scale and the beliefs about headache severity, disability, quality of life, anxiety and depression will also be evaluated and whether the characteristics of the three types of headaches are similar or different from kinesiophobia will be investigated. hypotheses: h0: the tampa kinesiophobia scale for headache is not valid and reliable for the turkish population in patients with migraine, tension-type or cervicogenic headaches. h1: the tampa kinesiophobia scale for headache is valid and reliable for the turkish population in patients with migraine, tension-type or cervicogenic headaches.


Eligibility criteria:
inclusion criteria: * being diagnosed with episodic/chronic migraine, tension-type headache and cervicogenic headache * being between the ages of 18-70, * being able to read, speak, understand and write turkish in order to understand and correctly answer the items/questions of the surveys and scales. exclusion criteria: * having a diagnosis of episodic/chronic migraine, tension-type headache, and any headache diagnosis other than cervicogenic headache, * having a history of any systemic disease such as malignant, inflammatory, acute fracture, surgery, neurological, psychological, or rheumatological. * not being able to read turkish.

Keywords: migraine tension-type headache cervicogenic headache kinesiophobia
muscle function after lung transplantation in patients with chronic obstructive pulmonary disease (copd)

Conditions: COPD

Summary: the purpose of the project is to investigate changes in the quadriceps muscle and cardiovascular regulation during exercise in relation to improved lung function after lung transplantation in patients with copd.

dysfunctional skeletal musculature of the lower limbs is related to low quality of life, exercise intolerance and higher mortality in patients with copd. limb muscle dysfunction in copd consists of muscle atrophy and reduced muscle strength but also intra-muscular alterations in oxidative capacity and mitochondrial function are often present. moreover, reduced blood flow to exercising muscle may also contribute to the muscle dysfunction in copd. the mechanisms responsible for muscle dysfunction in copd patients remain unclear but could be a consequence of reduced lung function, inflammation, medications or low physical activity. loss of lung function with copd is normally irreversible so the transition to near-normal lung function after lung transplantation is a unique model to investigate the adaptation of the limb muscle to improved lung function. thus, the purpose of this project is to investigate the effect of lung transplantation on limb muscle function (mitochondrial function, oxidative enzyme capacity, fiber type distribution, oxygen delivery/uptake) and daily physical activity level in patients with copd. the project has a translational focus on muscle dysfunction in copd and uses methodologies from clinical medicine, integrative physiology and molecular biochemistry in order to gain knowledge of mechanisms behind limb muscle dysfunction and exercise intolerance in copd.

Eligibility criteria:
inclusion criteria: * copd with or without alpha 1-antitrypsin deficiency on the waiting list for a lung transplantation * single or double lung transplantation * ≥ 18 years * ability to give informed consent exclusion criteria: * retransplantation * multiple-organ transplantation (heart-lung transplantation) * musculoskeletal disorders which substantially inhibits physical activity * need for crossmatching in connection with lung transplantation * anticoagulant therapy before lung transplantation (except acetylsalicylic acid)

Keywords: muscle dysfunction cardiovascular regulation lung transplantation (ltx)
sufentanil sublingual tablet system for postoperative pain management after total knee arthroplasty

Conditions: Postoperative Pain

Summary: the aim of this study is to assess the effectiveness of sublingual sufentanil tablets system (ssts, zalviso ®) to control postoperative pain after total knee arthroplasty in the context of early rehabilitation program. ssts is a novel patient controlled analgesia system wich does not require intravenous access, potentially improving pain control and promoting mobilization. ssts will be randomly compared to nurse-driven oral oxycodone.

even with multimodal analgesia (combining local anesthetic infiltration, corticosteroids, non-steroidal anti-inflammatory drugs and acetaminophen), total knee arthroplasty is associated with acute moderate-to-severe postoperative pain requiring opioids treatment. we compare the efficacy of ssts and oral oxycodone in this context. after written informed consent, patients will be randomly assigned postoperatively to ssts or oral oxycodone group at a ratio 1:1. pain scores, mobilization and patient satisfaction will be analyzed.

Eligibility criteria:
inclusion criteria: * adult patients (age ≥ 18 years) * scheduled for unilateral total knee arthroplasty under spinal anesthesia * american society of anesthesiologists (asa) class 1-3 exclusion criteria: * contraindication to medication used in our multimodal analgesia protocol (solumedrol, celecoxib, acetaminophen, ropivacaine) * allergy to study medications * history of addiction or preoperative chronic use of opioids * unicompartmental or revision knee replacement

Keywords: ssts oxycodone enhanced recovery after surgery
prevalence of port site hernia after mesh placement in laparoscopic cholecystectomy.

Conditions: Incisional Hernia

Summary: a prophylactic mesh fixation after fascial closure in umbilical trocar after cholecystectomy may prevent the trocar site hernia incidence. especially in patients who present certain risk factors.

randomized controlled trial. patients with more than two incisional hernia risk factors (age ≥70, bmi ≥30, diabetes mellitus, fascial enlargement) who undergo elective/emergent cholecystectomy. control arm: fascial closure with simple pds 2/0 stitches. study arm: fascial closure with simple pds 2/0 stitches and onlay polypropylene mesh placement. main outcome umbilical trocar site hernia incidence during a 3 years follow up. clinical and radiological assessment.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * laparoscopic cholecystectomy * emergent/elective * ≥2 risk factors: diabetes mellitus, age ≥70 years, bmi ≥30, fascial enlargement exclusion criteria: * conversion to laparotomy * emergent re intervention * immunosuppression * umbilical hernia

Keywords: hernia cholecystectomy mesh fixation
post marketing surveillance study for sayana®

Conditions: Product Surveillance, Postmarketing

Summary: post marketing surveillance to observe safety and efficacy of sayana® used for contraception and management of endometriosis-associated pain

post marketing surveillance required by korea mfds regulation. select among patients who randomly visit the site who meet the inclusion/exclusion criteria.

Eligibility criteria:
inclusion criteria: - subjects or legally authorized representatives of pediatric subjects agree to provide written informed consent form (ie, data privacy statement). 2.women subjects who are initiating treatment with sayana® for the first time as per the local product document for usage exclusion criteria: * known or suspected pregnancy. * undiagnosed vaginal bleeding. * known or suspected malignancy of breast. * active thrombophlebitis, or current or past history of thromboembolic disorders, or cerebral vascular disease. * significant liver disease. * known hypersensitivity to medroxyprogesterone acetate or any of its other ingredients. * women who are before menarche or who are post-menopausal. * treatment with any investigational agent or device within 30 days prior to the enrollment visit.

Keywords: sayana pregnancy contraception endometriosis-associated pain pms post marketing surveillance
office based intervention to reduce bottle use in toddlers: target kids! pragmatic randomized trial

Conditions: Educational Intervention and Toddler Bottle Use

Summary: observational studies support an association between bottle feeding beyond 15 to 18 months of age and lower socioeconomic status, excessive milk intake, dental caries, iron deficiency, behavioral issues and obesity. yet many parents, particularly those from low socioeconomic households, choose to feed their children by bottle much beyond this age. recognizing the need for further educational interventions for bottle feeding, the target kids! research collaboration recently developed a 5-minute bottle weaning educational intervention for the 9 month well-child visit. we undertook a pragmatic randomized controlled trial to evaluate its effectiveness involving 251 children recruited through target kids! (pmid: 20624802) the goal was to determine whether an office-based, educational intervention for parents of 9-month-old children could reduce bottle use and iron depletion at 2 years of age.


Eligibility criteria:
inclusion criteria: * children and their families who participated in the applied research group for kids (target kids!) pragmatic rct exclusion criteria: * n/a

Keywords: toddler bottle use educational intervention pediatrics iron deficiency
the efficacy of a 6-point transscleral suture fixation of a 3-looped haptics pc-iol implantation through scleral pockets for surgical management for microspherophakia

Conditions: Microspherophakia

Summary: by comparing the preoperative data and postoperative data of 9 patients of microspherophakia, we concluded that the 6-point transscleral suture fixation of a 3-looped haptics posterior chamber intraocular lens (pc-iol) through scleral pockets was a feasible method of pc-iol implantation in the surgical treatment of microspherophakia.


Eligibility criteria:
inclusion criteria: * microspherophakia was diagnosed and lens diameter\<9mm; * the lens subluxation was beyond the range of one quadrant and glasses cannot correct the vision; * lens dislocated into the anterior chamber; * lens dislocation caused elevated intraocular pressure (iop); * the lens contacted the corneal endothelium; * cataract; * corneal endothelial cell density\>1000/mm2; * the fundus was normal without retinal detachment, severe macular disease and optic nerve atrophy； * there was possible improvement in postoperative visual acuity measured by retinometer. exclusion criteria: * the lens is centered and the position of the lens is stable; * glasses can correct the vision obviously; * the reason for the elevated iop was independent with the lens; * a high possibility of corneal decompensation after surgery; * fundus function was poor and it is not expected to improve the vision after surgery; * combined with other ocular diseases which were not suitable for iol implantation; * combined with a systemic disease that the patient cannot tolerate the surgery.
evaluation of the results of closed kinetic chain exercises in patellofemoral pain syndrome

Conditions: Exercise Training

Summary: non-selective closed kinetic chain exercises and or selective closed kinetic chain exercises has been shown to increase vastus medialis obliquus muscle power in patellofemoral pain syndrome. however, the superiority of the exercises to each other has not been shown. this study aimed to evaluating the effects of different exercises on the stiffness of the vastus medialis obliquus and vastus lateralis muscles, pain management, functional scores, and thigh circumferences.

this randomized-controlled clinical trial included 40 patients (20 male and 20 female) who were admitted to hospital and who were clinically diagnosed with single-sided patellofemoral pain syndrome (pfps) and 40 healthy controls (20 male and 20 female). each group were randomized into subgroups according to diseased side of the pfps group (40 knees), healthy side of the pfps group (40 knees) and both side of the healthy control group (80 knees). randomization was applied with random-number generator (research randomizer. version 4.0). only one of the authors was aware of randomization. examiner and patient were blind to the relevant group. non-selective closed kinetic chain and selective closed kinetic chain exercises were applied for 6 weeks in all groups. thigh circumference measurement was performed 5-10 cm above the upper pole of the patella. in addition, evaluation was made with visual analog score (vas) and lysholm knee score (lks) score. vastus medialis obliquus (vmo) and vastus lateralis (vl) muscles of the participants were measured with shear wave elastography 1 day before the therapy and 6 weeks after therapy. written informed consent was taken from each patient.this study is in line with the declaration of helsinki. approval was obtained by the local ethics committee (17/07/2016-258642).

Eligibility criteria:
inclusion criteria: * having peripatellar/retropatellar pain while sitting,going up and down the stairs * walking for a long time, crouching down, running, and kneeling down * having a vas score of ≥3 during the evaluation and not developing these symptoms on a traumatic basis exclusion criteria: * tendinitis * osgood-schlatter syndrome * traumatic hip or knee injuries * osteoarthritis * plica syndrome * sinding-larsen-johansson syndrome * ligamentous instability * spinal pain * chondral lesion * patellar tendon pathology * distraction apophysitis of knee circumference

Keywords: elastography exercises non-selective pain patellofemoral
evaluation of the efficacy of rasagiline in apathy in drug-naïve patients with parkinson's disease by a multi-center study

Conditions: Drug-naïve Patients With Parkinson's Disease; Apathy

Summary: among the psychiatric symptoms observed in the premotor phase of parkinson's disease (pd) and/or in "de novo" patients, apathy is relatively frequent (estimated to 23%). however, the neuropathological bases of apathy are still unknown. however, recent data suggests that apathy could be linked to a more specific dopaminergic denervation in the ventral striatum. rasagiline increases the bioavailability of striatal endogenous dopamine by blocking the mao-b. some recent data suggest rasagiline could be effective to improve apathy in parkinson's disease. the primary outcome is to demonstrate a significant reduction of apathy using the lille apathy rating scale (lars) in drug naive patients with early diagnosed parkinson's disease, using a treatment by rasagiline.

study design : randomized, double-blind, rasagiline (1 mg) vs placebo study. parallel group (randomization 1/1). duration 3 months 16 recruiting centers in france population : 50 drug-naïve patients with parkinson's disease, with apathy. 2 groups : 25 patients with placebo and 25 patients with rasagiline. 3 visits * visit 1 : inclusion / randomisation/ first study medication dispensation * visit 2 (1.5 month after v1) : first evaluation and second study medication dispensation. * visit 3 (3 months after v1, final visit) : second evaluation

Eligibility criteria:
inclusion criteria: - drug-naïve patients with parkinson's disease (ukpdbb criteria) * no dementia (mattis dementia rating scale \> 130; mini mental sate examination ≥26) * no depression (madrs \< 15) * criteria of apathy from robert et al (2009) * at least mild apathy (≥-21 to lille apathy rating scale) * age : 35-70 y * affiliation to social security * agreement of patients exclusion criteria: * - any antiparkinsonian treatment (l.dopa, dopamine agonists, mao-b-i, amantadine, anticholinergics). patients treated by dopamine agonists but who have stopped it more than 3 months before their inclusion can be included. * ongoing severe psychiatric or somatic diseases * others treatments : * antipsychotics * antidepressants and anxiolytics (exclusion if the treatment is not stable the month before inclusion) * psychostimulants (methylphenidate, adrafinil, modafinil, deanol, vitamin c, sulbutiamine, glutamic acid, aspartic acid) * any contra-indication according to smpc * patients under guardianship * women without efficient contraception * person who participate to an other study

Keywords: drug-naïve patients with parkinson's disease apathy rasagiline
relation between lab finding and covid-19 severity

Conditions: COVID-19

Summary: severe acute respiratory syndrome coronavirus 2 (covid-19) poses substantial challenges for health care systems. with a vastly expanding amount of publications on covid-19, clinicians need evidence synthesis to produce guidance for handling patients with covid-19.

. conavirus belongs to the subfamily of ortho-coronavirinae in the family of coronaviridae and the order nidovirales. in 2003, a sars-cov had caused the out- break of severe acute respiratory syndrome. in december 2019, an "unknown viral pneumonia" out- break has been reported. finally, a novel coronavirus was detected, isolated virus was termed as sars-cov2, characterized as highly contagious and deadly. by the end of february 2020, more than 78,631 cases infected with sars-cov-2, and more than 2747 deaths were confrmed in china, and the covid-19 has been declared a pan- demic by world health organization. for those infected by sars-cov-2, some of the patients didnot show hypoxemia or respiratory stress during the course of covid-19, indicating a multifaceted disease of sars-cov-2 infection. therefore, one reliable and convenient biomarker is needed to predict the severity of covid-19 pneumonia. recently, several studies have reported that c-reactive protein (crp) is positively asso-ciated with severe dengue infection, and patients with higher plasma crp in the initial period of dengue, are at higher risk to develop plasma leakage. we examined which routine laboratory tests are associated with severe covid-19 disease, and the relation between the laboratory results and the security of covid19 diasease, in two of large upper egypt medical centers, which are aswan university and assiut university hospitals.

Eligibility criteria:
inclusion criteria: * age: all ages. * sex: males and females. * covid-19 patients approved by positive pcr. exclusion criteria: * patients with known chronic chest disease preceding the infection.

Keywords: laboratory severity covid-19