Kornimate/medical-research-clean huggingface dataset:
effects of different types of anaesthesia on intraocular pressure during lumbar disc herniation surgery

Conditions: Anesthesia; Disk Herniated Lumbar; Intraocular Pressure

Summary: the aim of this study was to investigate the effects of anaesthesia methods on intraocular pressure during lumbar disc surgery performed in the prone position.

the study included 75 patients with lumbar disc herniation between the ages of 18-75, with the american society of anesthesiologists (asa) 1-2. the patients were randomly divided into 3 groups: propofol, desflurane, spinal. intraocular pressure (iop) was measured at 5 time points throughout surgery, including baseline (t1), 10 minutes after anesthesia (t2), 10 minutes after prone positioning (t3: early prone), 30 minutes after prone positioning (t4: late prone), and 10 minutes after returning to the supine position (t5). hemodynamic parameters were measured at these time points. hemoglobin and hematocrit values were measured preoperatively and on the first postoperative day.

Eligibility criteria:
inclusion criteria: * asa 1-2 according to the american society of anesthesiologists (asa) classification. exclusion criteria: * who did not sign the informed consent form, * patients who required emergency surgery, * eye surgery recipients, * subjects with acute or chronic eye diseases other than refractive errors, * individuals detected to have elevated iop in preoperative measurements

Keywords: prone position intraocular pressure hemodynamics anesthesia,spinal anesthesia,general
treatment for partial lesions of the fingers flexor tendons : tangential resection or direct suture

Conditions: Flexor Tendon Injury; Lesions Of The Fingers Flexor Tendons

Summary: flexors tendon injuries are frequent and serious with a potential of definitive functional aftereffects. in the case of partial injury, the treatment is debated. there are 2 techniques of possible repair, the direct suture and the tangential resection. the investigators have already demonstrated that this last technique was favorable for injuries going to 50 %. in the case of partial section between 50 and 75 %, the investigators think that the technique of tangential resection compared with the direct suture would not increase the risks of secondary breaks, would authorize even an immediate mobilization and would decrease the secondary complications. the main objective is to highlight that the tangential resection is not lower than the classic technique on the clinical plan the secondary objectives are to highlight the non-inferiority of the tangential technique in clinical terms (pains, dexterity, complications), radiologics (mri, ultrasound) and functional (function, go back to leisures and professional activities)


Eligibility criteria:
inclusion criteria: * wound dating less than 48 hours * partial section from 50 % to 75 % of the flexor tendons (deep and/or superficial flexors, long flexor of the thumb) in zones 1, 2, 3, t1 and t2 * tendinous injuries on a single finger exclusion criteria: -

Keywords: partial section of the flexor tendons
cognitive function and electrocardiogram (ecg) during hypoglycemia and blockade of the renin-angiotensin system

Conditions: Type 1 Diabetes; Hypoglycemia

Summary: hypothesis: treating patients with type 1 diabetes with a certain antihypertensive drug preserve cerebral function during hypoglycaemia. background: studies have found that certain genetic variations leaves a subject with type 1 diabetes more prone to hypoglycaemia. it it thought to be a decline in cognition during hypoglycaemia that leaves them at risk of severe hypoglycaemia. the idea is tha when you suppress the genetic phenotype with a well known antihypertensive drug an improvement in cognition will occur and this will remove the patients tendency to severe hypoglycaemia. methods: the investigators want to explore whether the cerebral function is improved during hypoglycaemia in subjects with type 1 diabetes and the above mentioned genetic variation when treated with the antihypertensive drug candesartan.

we will include 25 type 1 diabetic patients from our outpatient clinic. they are already genotyped from another trial. each patient goes through two cycles with hyperinsulinemic glucose clamp induced hypoglycemia. the study is double blinded, randomised and placebocontrolled so the patients receive both candesartan and placebo but in different cycles. in each cycle patients will receive either candesartan or placebo for 7 days. after 8 days patients undergo a hypoglycaemic clamp during which primary and secondary endpoints will be measured. in the hyperinsulinemic hypoglycaemic clamp the patients will undergo an adjustment period towards euglycaemia. a period of approximately 1 hour of euglycemia, an hour of hypoglycemia and a period of recovery towards euglycemia. in each of these glycemic states primary and secondary outcomes will be measured.

Eligibility criteria:
inclusion criteria: * type 1 diabetes * danish spoken and written * ras activity score\>7 - diabetes duration \> 5 years * not pregnant and safe anticonception * signed informed consent. exclusion criteria: * treatment with an ace blocker * an arb og a renin blocker * treatment with other antihypertensive drugs * severe diabetic late complications * renal impairment * pregnancy and breastfeeding * previous reactions to study medication * heart insufficiency (nyha 3-4)\\ * known ischaemic heart disease * epilepsy * alcohol and drug abuse * suspicion of non-compliance, * plasma potassium \ 5.0 mmol/l.

Keywords: type 1 diabetes hypoglycaemia genetic susceptibility renin angiotensin system activity
hyaluronic acid in acute exacerbation of copd - duration of noninvasive assistance

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the objective of this study is to test the effect of high molecular weight hyaluronic acid (hmw-ha) on non invasive ventilation (niv) effectiveness in patients admitted to a sub-intensive care unit for respiratory failure due to acute exacerbation of chronic obstructive pulmonary disease (copd).

the objective of this study is to test the effect of hmw-ha on niv effectiveness in patients admitted to a sub-intensive care unit for respiratory failure due to acute exacerbation of copd. the design is a parallel-arm, single-blind, placebo-controlled randomized clinical trial. eighty patients, aged eighteen years or older, admitted for respiratory failure primarily due to copd exacerbation and requiring non-invasive ventilation will be enrolled and randomized to the study treatment (active or placebo). all patients will be treated with niv delivered using a hamilton c1 ventilator and medical therapy according to current guidelines (inhaled long-acting b2 agonists, inhaled long-acting anticholinergic, inhaled and systemic corticosteroids, antibiotics). patients randomized to the active intervention group will also receive hmw-ha (yabro® - 5 ml of saline containing 0.3% hyaluronic acid sodium salt) via nebulizer b.i.d., while patients randomized in the control group will receive a matching placebo. patients will be treated until weaning or until niv failure, defined as oro-tracheal intubation or death.

Eligibility criteria:
inclusion criteria: * aged 18 years of age or older * admitted for respiratory failure primarily due to copd exacerbation * requiring non-invasive ventilation * respiratory distress, as evidenced by moderate-to-severe dyspnea and use of accessory muscles of respiration * hypercapnic respiratory failure * high respiratory rate exclusion criteria: * respiratory arrest or the need for immediate intubation * upper airways obstruction * facial trauma * inability to cooperate
concentration and attentional deficits in pots and other autonomic neuropathies

Conditions: Autonomic Failure; Dysautonomia; Cognitive Impairment; Ehlers-Danlos Syndrome; Postural Tachycardia Syndrome; Pure Autonomic Failure

Summary: people with pots, autoimmune autonomic neuropathy (aan), pure autonomic failure (paf), sfn and ehlers danlos syndrome (eds) do not only suffer from orthostatic symptoms such as dizziness, headache, neck pain, blurred vision or (pre-) syncope. they also experience deficits in attention and concentration (more precisely deficits in selective perspective, operating speed, executive functions and memory performance) mainly in upright position. only few studies concerning cognitive impairment in autonomic neuropathies, their frequency, aetiology and therapy exist. many patients concerned, especially with pots, report attention deficits and "brain fog" with problems in their everyday life and work, predominantly in upright posture. specific symptomatic or medical therapies do not exist. medical treatment with modafinil is discussed and part of a current study at vanderbilt autonomic dysfunction centre (1-5). the investigators want to investigate if problems of concentration, attention and/or cognitive dysfunction exist in people with pots, aan, sfn and eds compared to healthy controls (hc). thus the investigators use detailed clinical, autonomic and neuropsychological tests in different body positions (lying, sitting and standing) as also acute therapy (leg crossing).

we are still recruting healthy controls and patients with autoimmune autonomic neuropathy in order to perform titl table examination and laboratory testing on day one, ono an empty stomach, without morning medication. cognitive testing is performed on day two after randomization in three groups: lying, standing and standing with legs crossed.

Eligibility criteria:
inclusion criteria: * aan, sfn, heds, pots or healthy control * diagnosis in our clinic on the basis of anamnesis, clinical data as neurological examination, tilt table, qst, skin biopsy, norepinephrine values, vitamine b12, antibodies exclusion criteria: for all participants * pregnancy, nonage,severe heart insufficiency, deep brain stimulation, pace maker, drug consumption, large fibre polyneuropathy for controls * medication influencing blood pressure, psychiatric disease, synkopes or dizziness, neurological disorders esp. polyneuropathy, dementia, vitamine or iron deficiency
timing effect of ultrasound-guided pvb after robotic cardiac surgery

Conditions: Nerve Block; Cardiac Surgery

Summary: this study is to evaluate whether the administration of ultrasound-guided paravertebral block (pvb) after surgery would produce better postoperative pain control and fast postoperative recovery after robotic cardiac surgery. half of participants will receive pvb before surgery, while the other half will receive pvb at the end of surgery.

ultrasound-guided pvb (either before surgery, or after surgery) is the standard postoperative pain management for robotic cardiac surgery. this technique is to inject local anesthetic (numb medication) around nerve to decrease pain. but the optimal time of pvb is unknown. the administration of pvb before surgery can help pain control during the surgery and after surgery. but the duration of pvb could be reduced because surgery itself can last 5-6 hrs. the pvb after surgery will not provide pain control during surgery, but may provide longer pain control after surgery, and may help participants faster recovery after surgery.

Eligibility criteria:
inclusion criteria: 1. age ≥ 18 yrs 2. asa i-iv 3. either gender exclusion criteria: 1. refusal to participate in the study 2. age\< 18 yrs 3. contraindications to regional blockage including but not limited to: 1. patient refusal to regional blockade 2. infection at the site of needle insertion 3. systemic infection 4. bleeding diathesis or coagulopathy

Keywords: postoperative pain
an observational study of methoxy polyethylene glycol-epoetin beta (mircera) in chronic kidney disease participants on dialysis

Conditions: Chronic Kidney Diseases

Summary: this observational, multi-center, open-label, prospective study will evaluate the relationship between serum interleukin-6 (il-6) and c-reactive protein (crp) levels and methoxy polyethylene glycol-epoetin beta dosage in participants with chronic kidney disease (ckd) on dialysis. participants will be recruited who are on stable methoxy polyethylene glycol-epoetin beta maintenance therapy or will initiate therapy with methoxy polyethylene glycol-epoetin beta.


Eligibility criteria:
inclusion criteria: * ckd participants undergoing dialysis * participants initiating esa treatment with methoxy polyethylene glycol-epoetin beta or participants on stable methoxy polyethylene glycol-epoetin beta maintenance therapy * adequate iron status defined as: serum ferritin above or equal to 100 micrograms per liter (mcg/l) or transferrin saturation above or equal to 20 percent (%) exclusion criteria: * conditions known to cause inadequate response to esa treatment * anemia other than symptomatic anemia associated with ckd
oral omega-3 for reduction of kidney scar due to pyelonephritis in children

Conditions: Acute Pyelonephritis(APN)

Summary: urinary tract infections (uti) are a common and important clinical problem in childhood.upper urinary tract infections (ie, acute pyelonephritis) may lead to renal scarring, hypertension, and end-stage renal disease.pathogenesis of acute pyelonephritis (apn) is associated with urinary tract anatomy and function, bacterial virulence factors, the host innate immune system and production of free radicals. oxygen-free radicals and oxidative stress play a role in renal scar formation after an apn. oxygen-free radical scavengers and antioxidants can reduce tissue damage and renal scaring during acute pyelonephritis.we want to publish a study that indicates that antioxidant therapy with omega-3 given to children with pyelonephritis may indeed lower the risk for renal scarring. several studies show that omega-3 alleviated oxidative stress and inflammation.this study is a simple randomized clinical trial (rct) evaluating the effect of omega-3 in addition to antibiotic on preventing renal scaring after acute pyelonephritis in children. this randomized clinical trial on 60 patients in 2 groups (intervention \& control) is conducted.children aged 1 month to 10 years with positive urine culture, clinical findings, and 99mtc-dimercaptosuccinic acid (dmsa) scintigraphy-based evidence in favor of acute pyelonephritis were enrolled into a clinical trial. patients with neurogenic bladder, systemic hypertension, obstructive uropathy and high grade vesicouretera are excluded.patients in intervention group are administered omega-3 based on body weight in divided doses in addition to antibiotic regimens and patients in control group received antibiotic regimens without omega-3. primary outcome is the development of renal scar by doing dmsa renal scan on the 7th day of admission and four to six months after the intervention and compared between groups.also,measurement of urinary biomarker of acute kidney injury (ngal) three days after antibiotic or omega-3 administration for assessing of subsequent scarring in both groups will be done . secondary outcome is the incidence and severity of renal scarring after pyelonephritis and response to treatment between two groups.


Eligibility criteria:
inclusion criteria: * children aged 1 month to 10 years with positive urine culture, clinical findings, and 99mtc-dimercaptosuccinic acid (dmsa) scintigraphy-based evidence in favor of acute pyelonephritis exclusion criteria: * neurogenic bladder, * systemic hypertension, * obstructive uropathy, * high grade vesicoureteral
the influence of whole-body vibration training on postural stability in people with generalized joint hypermobility

Conditions: Hypermobility, Joint

Summary: the aim of this study was the assessment of muscle flexibility after 2-weeks of whole-body vibration (wbv) training in people with generalized joint hypermobility (gjh). the study included 33 participants aged 22-25 years. 12 participants were classified into the gjh group and 21 into the control group (cg). the study included the beighton score and muscle flexibility tests: straight leg raise test (slr), popliteal angle test (pa), and the modified thomas test. these tests were performed before and after the short-term wbv program, which consisted of six sessions (frequency: 15 hz and 30 hz, amplitude 3 mm, 3 trials x 3 min.).


Eligibility criteria:
inclusion criteria: * healthy young adults exclusion criteria: * rheumatological disease * orthopaedic disease * neurological disease * genetic disease * cardiovascular system disease * previous injuries of lower limbs * surgeries of lower limbs and spine * pain over 3 months of lower limbs and spine * pregnancy * implants * the benign joint hypermobility syndrome (the brighton criteria) * the absence during one or more training day
the effect of a new biomechanical device

Conditions: Osteoarthritis; Joint Replacement; Fractures

Summary: the purpose of this study is to examine (retrospectively) the effect of a new biomechanical device on gait patterns of patients suffering from musculoskeletal disorders. the analysis is conducted on an existing database of the therapy center.

patients treated in the therapy center undergo a computerized gait test and complete several pain and function questionnaires at fixed time point. we examined the effect of the treatment on the level of pain, function and quality of life as well as on the gait patterns of these patients. measurements were taken at baseline, after 3 months, and after 6 months.

Eligibility criteria:
inclusion criteria: * knee\\hip oa * knee\\hip joint replacement * ankle fractures\\instability * nslbp exclusion criteria: * neurological disorders * lack of balance (2 falls in the last year) * incapable to complete a questionnaire
examining the impact of school-based dental screening

Conditions: Dental Caries

Summary: this study examines the effectiveness of school dental screening in promoting dental attendance and reducing untreated caries among primary schoolchildren in riyadh, saudi arabia.

background: dental caries is one of the most common diseases affecting children in saudi arabia despite the availability of free dental services. school-based dental screening could be a potential intervention that might impact uptake of service and subsequently dental caries. aim: to examine the effectiveness of school dental screening in promoting dental attendance and reducing untreated caries among primary schoolchildren in riyadh, saudi arabia. methods: this is a cluster randomized controlled trial comparing referral of screened-positive children to a specific treatment facility (king saud university dental college hospital) against the current practice (information letter advising parents to take their child to a dentist). a total of 1000 children in 12 schools will be recruited. schools (clusters) will be randomly selected and allocated to either group using computer software. clinical assessment for dental caries will be conducted at baseline and after 12 months by dentists using the world health organisation (who) criteria. different clinical teams will be used for each trial group to ensure blinded outcome assessment. data on socio-demographic, behavioural and dental visits will be collected at baseline and follow-up. outcome measures will be the change in number of decayed teeth and the number of dental visits over 12 months. discussion: this project will use a robust design to provide high level of evidence on the clinical benefits of school dental screening. the findings will potentially inform policies related to the continuation/ implementation of school-based dental screening in saudi arabia.

Eligibility criteria:
inclusion criteria: * children aged 6 to 11 years (1st -5th grade at school) at baseline. * both saudis and non-saudis. * children for whom the person with parental responsibility has signed the consent form exclusion criteria: * children in 6th grade (12-year-olds) as they would have left schools by the time of the follow-up assessment (12 months later). * children with any medically compromised condition such as congenital heart disease, haematological conditions, immune deficiency disease and end-stage renal disease. * children that refuse to participate (assent) in the study.

Keywords: dental visits school-based program dental screening dental caries
humoral and cellular response in shift workers

Conditions: Other Condition That May be a Focus of Clinical Attention

Summary: the purpose of this study is to access whether shift workers (morning, afternoon or night) vaccinated against hepatitis a would have some humoral and cellular response impairment.

sleep regulates immune functions. in this sense, we asked whether shift workers (morning, afternoon or night) vaccinated against hepatitis a would have some humoral and cellular response impairment. men (18 to 55 years) will be recruited through different forms of media (electronic, newspapers, radio and magazines). the shift workers sleep pattern will be recorded polysomnographically. subsequently, the volunteers will be underwent vaccination against hepatitis a (2 doses) and after 30, 60 and 90 days, blood samples will be collected to assess the humoral response in the experimental groups. the hormones prolactin, growth hormone, cortisol, adrenaline and noradrenaline will also be evaluated. indeed, stimulations in culture will be conducted to assess the cellular response profile against the vaccination through the production assessment of il-4, ifn-γ, il-2 and tnf-α.

Eligibility criteria:
inclusion criteria: * shift workers * naive immune status against hepatitis a confirmed by hepatitis a virus (hav) antibodies levels below 5 miu/ml exclusion criteria: * smokers * individuals with complaints and/or sleep disorders * acute or chronic disease * use of medication during the study period. * acute illnesses

Keywords: shift work hepatitis a vaccination humoral response cellular response
comparison of two approaches to weight loss follow-up study

Conditions: Obesity

Summary: this is a follow-up research study to determine if there are any differences in the long-term maintenance of two diet groups, the atkins' diet (low-carbohydrate) or the learn program (low-fat). the atkins' diet continues to get a significant amount of popular attention and very little scientific evaluation. due to the small amount of scientific data to support a low-carbohydrate diet and given the wide spread use of this type of diet, it is important to evaluate the long-term safety and effectiveness of the atkins' diet. we will evaluate whether there are any differences between these two groups 3-years after participation in the initial 1-year study period. we will specifically assess weight, cholesterol levels, glucose and insulin levels, and eating habits and mood as we did originally.

\*\*\*please note: only those who participated in the original study of low carbohydrate and low fat diets are eligable for enrollment in this follow-up study\*\*\*

Eligibility criteria:
inclusion criteria * body mass index between 30 and 40 * live and work within 1 hour of the study site * stable psychological status exclusion criteria * history of heart disease, heart attack, or stroke * blood pressure \>140/90 mmhg * abnormal cholesterol levels * significant psychiatric illness * any medication that affects weight or metabolic rate * presence or history of a chronic disease that is known to affect appetite, food intake, or metabolism (i.e., diabetes, thyroid disease, or cancer) * currently using antidepressants, steroids, tobacco, or illegal drugs * pregnant, breastfeeding, or planning pregnancy * 10 lb change in weight within 6 months of study entry * history of malignant arrhythmias or cerebrovascular, renal, or hepatic disease * history of protein wasting diseases or gout * severe arthritis * osteoporosis * certain types of hormone replacement therapy * currently following a vegetarian diet

Keywords: weight loss