Kornimate/medical-research-clean huggingface dataset:
longitudinal study of primary osteoporosis in shanghai postmenopausal women

Conditions: Primary Osteoporosis

Summary: to popularize knowledge of prevention and health care of osteoporosis.to investigate the prevalence of primary osteoporosis in community residents.

1. objective: * to popularize knowledge of prevention and health care of osteoporosis. * to investigate the prevalence of primary osteoporosis in community residents. 2. method: * the survey study included the five boroughs of six communities in shanghai (xuhui district 2, pudong new area 1, minhang district 1, pudong new area 1, jiading district 1). 10,000 participants are expected to be included. * through a questionnaire and physical examination form, carries on the investigation to the 50-85 years old postmenopausal women during the 3-year follow-up period. * make a survey of bone mineral density,sf-36,international osteoporosis foundation one-minute osteoporosis risk test,markers of bone metabolism test,eq-5d,hepatic-renal function test and thyroid stimulating hormone level test. * physicians in each community as the backbone, shanghai university of traditional chinese medicine, longhua hospital is responsible for personnel training. * shanghai clinical research center is responsible for program and data management. * shanghai district health and family planning commission is responsible for coordinating the organization.

Eligibility criteria:
inclusion criteria: * had clinical diagnosis of osteoporosis. * with bone mineral density by dual energy x-ray examination, t value \<-2.5 or less. * be willing to and be able to join in the study and signed informed consent. exclusion criteria: * excluding the impact of endocrine diseases of bone metabolism (gonadal, adrenal, parathyroid and thyroid disease), rheumatoid arthritis and other autoimmune diseases that affect the absorption of calcium and vitamin d and regulation of the digestive tract and kidney disease, multiple myeloma and other malignant diseases, long-term use of corticosteroids or other drugs affecting bone metabolism, and a variety of congenital and acquired diseases of bone metabolism. * if they were unable to complete the study survey.
the role of statins in preventing cerebral vasospasm secondary to subarachnoid hemorrhage

Conditions: Aneurysmal Subarachnoid Hemorrhage

Summary: delayed ischemia caused by cerebral vasospasm remains a common cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage. a great deal of drugs has been tested in the last years. phase ii randomized clinical trials have demonstrated that statin decreases the incidence of symptomatic cerebral vasospasm after spontaneous subarachnoid hemorrhage. clinical, double blind, randomized controlled trials with placebo. discussion: even though some articles have shown that statins provide better prognosis, some issues remain in debate, e.g., treatment duration and the choice of the statin.


Eligibility criteria:
inclusion criteria: * age between 18 and 65 years old, hunt-hess scale \< 3 exclusion criteria: * liver disfunction, previous use of statin, hunt-hess scale 4 or 5.

Keywords: vasospasm prevention
parkinson brasil - database on motor and non-motor aspects of parkinson's disease in brazil

Conditions: Parkinson Disease

Summary: this is an observational, cross-sectional study with a control group, with the general objective of developing and evaluating a national database, unprecedented in brazil, containing clinical, epidemiological, motor, and non-motor aspects of parkinson's disease (pd). the database will be open and accessible to national and international researchers in order to contribute to the advancement of research related to pd. the aim is to collect data, in a paired way, from a control group and an experimental group. data collection will include the application of questionnaires, the execution of motor activities, and clinical scales. information that can identify the participants will be removed from the database for later storage in a repository. quantitative, qualitative, and descriptive variables from the database will be estimated in order to characterise and contrast the groups studied. the results of this study will contribute to a better characterization of the staging of pd as a function of the epidemiological, motor, and non-motor aspects evaluated, as well as to the development of technologies and methods that can be applied in clinical practice.


Eligibility criteria:
inclusion criteria: * experimental group: (i) present a neurological diagnosis of parkinson's disease; (ii) be classified between stages i to iv of the hoehn \& yahr scale; (iii) have central visual acuity equal to or greater than 20/40 (equivalent to 0.50) in each eye or equal to or greater than 20/30 (equivalent to 0.66) in one eye according to the snellen scale. * control group: (i) not having a neurological diagnosis of parkinson's disease or other neurological disease that resembles pd; (ii) have central visual acuity equal to or greater than 20/40 (equivalent to 0.50) in each eye or equal to or greater than 20/30 (equivalent to 0.66) in one eye according to the snellen scale. exclusion criteria: for both groups, individuals who have other neurological or musculoskeletal diseases that interfere with the execution of the tests will be excluded.

Keywords: parkinson's disease motor assessment non-motor assessment database computer vision inertial sensors
echocardiographic examination performed by nurses in cardiac intensive care unit

Conditions: Heart Failure; Myocardial Infarction; Pleural Effusion

Summary: the purpose of this study is: * to study the clinical usefulness of nurse-performed ultrasound and echocardiographic examinations in a cardiac intensive care unit. * to study reproducibility of nurse-performed ultrasound and echocardiographic examinations in a cardiac intensive care unit. * to study which ultrasound measure that best correlate with the amount of pleural effusion.

for a period of 1 year patients in our cardiac intensive care unit will be recruited to nurse-drive ultrasound and echocardiographic examinations, after informed consent. nurses underwent a training programme and their skills are approved by cardiologist. our department does not always have a cardiologist on duty and indication for nurse-driven ultrasound examination is decided by the doctor responsible for the treatment, who not always are trained in echocardiography/ultrasound. we aim to study the described hypothesis.

Eligibility criteria:
inclusion criteria: * patient at cardiac intensive care unit, levanger hospital * doctor responsible for treatment finds echocardiographic/ultrasound examination indicated. exclusion criteria: * none
yamani technique versus proline mesh for intraocular lens scleral fixation in aphakia

Conditions: Aphakia, Postcataract

Summary: the study aims to describe a new method of sulcus fixation of intraocular lenses (iols) using a prolene mesh and to compare its outcomes with yamani technique.

properly positioned posterior chamber iol (pciol) offers many advantages over an anterior chamber iol (aciol). the potential advantages of pciols over aciols include a reduction in the number of optical aberrations (e.g. magnification, aniseikonia, lens edge glare, flutter), a decreased incidence of secondary glaucoma, and free movement of the pupil to control the amount of light entering the eye. the risk for corneal decompensation, secondary glaucoma, and cystoid macular edema may be less with pciols than with aciols. in the absence of capsular support, many techniques have been described to secure the haptics to the sulcus region. all described techniques focus on iol haptics fixation to the scleral wall at two or more points. these techniques are not free of complications, including iol tilt, misalignment, myopic shift, iol suture rupture, and dislocation. in a previous study, othman et al compared classic ab-externo two-point iol fixation with a new technique of iol scleral fixation based on fashioning trans-scleral, a double rectangular suture sulcus reconstruction (drssr) to support the iol optic, thus providing a cushion to the iol being positioned in the sulcus. aim of

Eligibility criteria:
inclusion criteria: * patients aged 40 years * aphakic patients (post-traumatic or after complicated cataract surgery without capsular support). exclusion criteria: * corneal decompensation. * jeopardized specular microscopy * retinal or choroidal detachment * retained intraocular foreign body * uveitis, scleromalacia * reubeosis irides * previous anti-glaucoma surgery.
mini crush or double kissing crush stenting techniques for complex left main bifurcation lesions

Conditions: Left Main Coronary Artery Disease

Summary: the crush technique has evolved significantly since its introduction to the literature by colombo et al in 2003, with multiple iterations including mini-crush (mc) and double kissing-crush (dkc) stenting techniques. the main principle of crush techniques for complex bifurcation lesions is to protrude the side branch (sb) stent towards the main branch to adequately cover the sb ostium and minimize the risk of sb ostium restenosis. it was noticed that the 4-5 mm protrusion of the sb stent resulted in a large volume of the crushed stent and the technique was modified into mc which aimed for approximately 1-2 mm protrusion by galassi et al in 2007. despite all the disadvantages of the crush technique, the final kissing balloon inflation (kbi) rate of this technique, along with several iterations has been up to 98%. moreover, a recent meta-analysis showed that mc was associated with a reduction in risk of major cardiovascular events compared to provisional stenting, crush, and culotte techniques. the dkc is a planned 2-stent technique introduced by chen et al. the ultimate innovation of this approach is that it is designed to increase the success rate of the final kbi. provided recrossing of the crushed stent occurs through the proximal cell: another advantage of the dkc technique is to improve the success of kbi. the dkc significantly reduced major cardiovascular events (mace) compared to provisional stenting, crush, tap, and culotte. until now, no clinical investigation has compared the dkc and mc in patients with complex left main bifurcation lesions. therefore, this study sought to determine the clinical results of dkc and mc stenting techniques under long-term follow-up.


Eligibility criteria:
inclusion criteria: * true complex left main bifurcation lesions * stenting with double kissing-crush or mini-crush as a 2-stent strategy * participation in regular clinical follow-up exclusion criteria: * prior history of coronary artery bypass grafting * cardiogenic shock * end-stage liver or kidney disease * allergy to antiplatelet therapy or contrast media * inappropriate dual antiplatelet therapy * critically ill with \< 1-year life expectancy * absence of all medical records * pci for st-segment elevation myocardial infarction or in-stent restenosis * non-complex bifurcation lesions * treated with a bare metal stent
clinical practice guidelines and impact of audit and feedback in the emergency department

Conditions: Shock, Septic; Community Acquired Pneumonia

Summary: this study will develop and test an intervention given to emergency medicine providers to improve adherence to clinical practice guidelines (cpgs) for pneumonia and sepsis.

this study will be performed at denver health medical center, a 477-bed urban, safety-net, acute-care hospital located in denver, colorado. the adult ed is staffed by board-certified emergency physicians at all times. these physicians supervise the care of all patients being managed by resident physicians, nurse practitioners, physician assistants, and medical students. approximately 430 patients are admitted to the hospital from the ed each year with community-acquired pneumonia (cap) and severe sepsis (ss). adherence to cpgs will be measured at the level of the attending emergency physician. all employed, attending emergency physicians working clinically in the adult ed at denver health medical center at the start of the study will be included. the investigators will use a step-wedge design to randomize physicians into clusters. randomization of physicians into clusters and randomization of clusters to intervention timing will occur one week prior to delivery of the intervention to cluster one. he intervention will consist of monthly audit and feedback on adherence to cpgs for cap and ss. once a cluster enters its first intervention month, all physicians in that cluster will receive an email detailing their adherence to both cap and ss cpg for every month since the start of the study. adherence to the entire cpg as well as each component of the cpg will be provided. in addition, physicians will be shown the median prevalence of adherence for all physicians as well as where their adherence ranks among their physician group. lastly, in a separate secure email, physicians will be given patient identifiers (i.e., name, mrn, date of visit) for each patient that received non-adherent care and will be told which component of care was not adherent to the respective cpg so that they can review the case themselves, if desired.

Eligibility criteria:
inclusion criteria: * attending emergency medicine physicians working clinically in the adult emergency department at denver health medical center at the start of the study. exclusion criteria: * none. all eligible physicians will be included.

Keywords: clinical practice guidelines
migraine attack treatment response molecular and clinical biomarkers (mambo) phase i

Conditions: Migraine Disorders

Summary: the goal of this observational study is to identify differential traits in spontaneous migraine attacks that can help us predict the response to treatment with sumatriptan. participants will be asked to register the headache characteristics before and after taking sumatriptan and whether the treatment was effective or not during four migraine attacks.

there is still an unmet need in acute migraine treatment, some patients don't respond properly to acute medication. there are some interindividual differences in clinical characteristics of migraine attacks. these differences may determine the response to acute treatment. describing the phenotypical differences between patients who are responders and patients non-responders will allow us to offer a personalized treatment. the aim of the study is to determine which characteristics are associated with a response or a non-response to acute treatment with sumatriptan. participants will be asked to register the headache characteristics and accompanying symptoms during 4 spontaneous migraine attacks and its response to treatment with sumatriptan.

Eligibility criteria:
inclusion criteria: * migraine with or without aura diagnosis according to ichd-3 criteria * \<8 migraine days per month * be able to read, write and understand instructions. * have internet access and mail address * signing of the informed consent exclusion criteria: * active preventive treatment for migraine * active medication with an effect over the central nervous system * serious physical or psychiatric condition * cardiovascular or hepatic disease * pregnant or breastfeeding women * any triptan contraindication * severe migraine attacks without previous response to triptans or nsaids

Keywords: migraine triptan
10-week leucine supplementation in cerebral palsy

Conditions: Cerebral Palsy; Cerebral Palsy, Mixed; Cerebral Palsy Ataxic

Summary: the purpose of this study is to assess the effects of 10-weeks leucine supplementation on muscle growth, metabolism, body composition, inflammation and wellbeing in adolescents and young adults with cp.

cerebral palsy (cp) is caused by damage to the developing brain and descending pathways, leading to altered patterns of growth and development. those with cp may encounter early symptoms of paresis and spasticity, leading to progressive secondary musculoskeletal complications, including increased muscle atrophy and abnormal growth of contractile and non-contractile tissue. this causes significant weakness of the muscle and compromises daily motor function, leading to substantial declines in activities of daily living and independence. as such, interventions aimed at increasing muscle mass or preventing muscle atrophy for those with cp must be established. it is well established that dietary protein ingestion stimulates protein synthesis and inhibits proteolytic pathways, resulting in a positive protein balance and net muscle mass gain. in particular, leucine (a branched chain amino acid; bcaa), has been used to facilitate protein synthesis and muscle growth. leucine also has anti-inflammatory roles, some of which are central in origin and have been shown to effect mood and features of wellbeing. however, there has been no investigation of the effects of leucine supplementation on any of these parameters in cp. therefore, the purpose of this study is to assess the effects of 10-weeks leucine supplementation on muscle growth, metabolism, body composition, inflammation and wellbeing in adolescents and young adults with cp.

Eligibility criteria:
inclusion criteria: * a diagnosis of spastic cerebral palsy * aged 12-22 years exclusion criteria: * orthopaedic surgery of the upper-limbs in the past 12 months * botulinum toxin type a injections in the past 6 months * serial casting in the past 6 months * insufficient cognitive understanding to comply with the assessment procedures and intervention * liver and/or kidney dysfunction
supine sleeping after total hip replacement

Conditions: Osteoarthritis; Hip Dislocation

Summary: aim of the current study is to test the non-inferiority hypothesis of differences in early hip dislocation between a group of patients who will be restricted to sleep in supine position and a group without restricted sleeping position during the first eight weeks after a total hip replacement following a posterolateral surgical approach

stratified block randomized controlled trial

Eligibility criteria:
inclusion criteria: * placement of a primary total hip replacement via the posterolateral approach by a high volume orthopaedic surgeon * patients with a asa-classification of i or ii exclusion criteria: * blindness * replacement of 2nd total hip within six months after the1st total hip replacement surgery * insufficient knowledge of the dutch language * collum fracture * infection of total hip replacement * cognitive dysfunction * wheelchair dependability * hypermobility * alcohol abuse * neurological disorders such as parkinson and stroke

Keywords: arthroplasty replacement hip posterolateral surgery precautions
a retrospective chart review on the use of biologics in monotherapy for the treatment of patients with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: this non-interventional, retrospective, cross sectional chart review study will evaluate the management of rheumatoid arthritis patients with a biologic in monotherapy. data from eligible patients will be collected from the patient's last visit on the prior rheumatoid arthritis treatment and from the most recent visit for the biological monotherapy.


Eligibility criteria:
inclusion criteria: * adult patients, \>/= 18 years of age * diagnosis of rheumatoid arthritis by a rheumatologist * patient being prescribed with a biologic in monotherapy exclusion criteria: * n/a
safety of endoscopic resection of large colorectal polyps: a randomized trial.

Conditions: Colon Polyps

Summary: the effectiveness of colonoscopy in reducing colorectal cancer mortality relies on the detection and removal of neoplastic polyps. because the risk of prevalent cancer and of transition to cancer increases with polyp size, effective and safe resection of large polyps is particularly important. large polyps ≥20mm are removed by so-called endoscopic mucosal resection (emr) using electrocautery snares. resection of these large polyps is associated with a risk of severe complications that may require hospitalization and additional interventions. the most common risk is delayed bleeding which is observed in approximately 2-9% of patients. a recent retrospective study suggests that closure of the large mucosal defect after resection may decrease the risk of delayed bleeding. however, significant uncertainty remains about the polypectomy techniques to optimizing resection and minimizing risk. important aspects that may affect risk include clipping of the mucosal defect and electrocautery setting.

aim 1. the primary aim of the study is to compare the rate of delayed bleeding complications in patients undergoing endoscopic resection of large polyps between: * a) closing the mucosal defect after resection (clip group) and * b) not closing the mucosal defect after resection (no clip group). aim 2. the secondary aim of the study is to compare the rate of overall complications in patients undergoing endoscopic resection of large polyps between two cautery settings: * a) low power coagulation and * b) endocut.

Eligibility criteria:
inclusion criteria: * any patient ≥18 and ≤89 who presents for a colonoscopy and who does not have criteria for exclusion * patients with a ≥20mm non-pedunculated colon polyp exclusion criteria: * patients with known (biopsy proven) invasive carcinoma in a potential study polyp * pedunculated polyps (as defined by paris classification type ip or isp) * patients with ulcerated depressed lesions (as defined by paris classification type iii) * patients with inflammatory bowel disease * patients who are receiving an emergency colonoscopy * poor general health (asa class\>3) * patients with coagulopathy with an elevated inr ≥1.5, or platelets \<50 * poor bowel preparation * pregnancy

Keywords: large colon polyps polyp resection colon cancer screening colonoscopy endoscopic mucosal resection
understanding immunity to sars-cov-2, the coronavirus causing covid-19

Conditions: Coronavirus

Summary: the purpose of this study is to test over time immunity to sars-cov-2, a recently identified coronavirus responsible for the 2019 world-wide pneumonia outbreak known as covid-19. adults and children diagnosed with covid-19 as well as controls without covid-19 will be invited to participate in this study.


Eligibility criteria:
inclusion criteria: * adults (18 years and older) and children with confirmed covid-19 (rt-pcr diagnosis). * adults (18 years and older) and children without covid-19 for controls (who test negative for covid-19 but may have viral symptoms) exclusion criteria: * patients with special risks attendant to venipuncture will be excluded.

Keywords: immunity