Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of a covered self-expandable dual-layered metallic mesh stent (uventa) in ureteral obstruction

Conditions: Ureteral Obstruction

Summary: the purpose of this study is to evaluate efficacy and safety of a covered self-expandable dual-layered metallic mesh stent (uventa) in ureteral obstruction.

prospective, multi-center, open label, single arm study 1. treatment - covered self-expandable dual-layered metallic mesh stents(csems) are implanted in patents with malignant ureteral obstruction 2. follow up * assessments including x-ray(kub), are done 3, 6, 12, 18 and 24 months after the procedure. * diuretic ri scan (dtpa, mag-3) 3, 6, 12 months after the procedure * imaging such as ivp(intravenous pyelogram), ultrasonogram, ct(computed tomogram) are performed at 6 and 12 months.

Eligibility criteria:
inclusion criteria: 1. patients who voluntarily agree to participation and submitted a written informed consent for this study, and 20\~80 years 2. one out of following cases below apply to patients who have malignant ureteral obstruction or have benign ureteral obstruction without improvement after previous treatment * patients who doesn't want to have regular replacement of plastic stent * patients who has no improvement of obstruction after plastic stent implant * patients who want other urinary diversion because of stimulatory sign or pain due to plastic stent 3. patients with no previous ureteral metal stenting procedure experience. 4. patients with more than 6 months of life expectancy 5. patients understanding the objective of the study and who are willing to sign a consent exclusion criteria: 1. patients with urothelial carcinoma 2. patients with bladder invasion of malignant tumor 3. patients with bladder dysfunction or obstruction of lower urinary tract 4. one or more times recurrent urinary stone in the last 3 years 5. 2 or more times upper urinary tract infection without upper urinary tract obstruction 6. karnofsky scores \< 60 7. patients with bacteriuria 8. inadequate patient to participate in the study as judged by the investigator

Keywords: covered metal stent ureteral obstruction
national cerebral and cardiovascular center (ncvc) stroke registry

Conditions: Stroke, Acute

Summary: a single-center registry of patients with acute ischemic stroke, intracerebral hemorrhage, and transient ischemic attack (tia) who are emergently managed in the stroke care unit in the national cerebral and cardiovascular center (ncvc) to determine change in underlying characteristics, stroke features and severity, process for diagnosis and acute treatment, and long-term outcomes of stroke/tia patients over the years.

this is a single-center registry of consecutive patients with acute ischemic stroke, intracerebral hemorrhage, and transient ischemic attack (tia) who are emergently managed in the stroke care unit in the national cerebral and cardiovascular center, a flagship stroke center in japan. neurological emergencies other than stroke/tia and subclinical cerebrobvascular inpatients are also enrolled. data are collected and analyzed to determine change in underlying characteristics, stroke features and severity, process for diagnosis and acute treatment, and long-term outcomes of stroke/tia patients over the years. the national cerebral and cardiovascular center was founded in 1977 in suita, osaka, in order to provide the public with the most advanced treatment for cardiovascular and cerebrovascular diseases and to conduct the highest level of basic as well as applied research on the cardiovascular and cerebrovascular systems.

Eligibility criteria:
inclusion criteria: 1. a patient with acute ischemic stroke, intracerebral hemorrhage, and transient ischemic attack who are emergently managed in the stroke care unit or stroke units in the national cerebral and cardiovascular center (ncvc) 2. consent to participate in the registration by a patient or relatives obtained using an opt-out approach by the demonstrating contents of the registration on the hospital bulletin board exclusion criteria: 1) patients considered by the investigator to be unsuitable for participating in this registry

Keywords: acute ischemic stroke acute intracerebral hemorrhage transient ischemic attack
cardiotoxicity of aluminum phosphide poisoning; tropinin and ckmb as early biomarkers

Conditions: Cardiotoxicity; Aluminum Phosphid Poisoning

Summary: aluminum phosphide (alp) or rice tablet is a cheap pesticide. when it comes in contact with acid (gastric acid) or moisture, it releases phosphine (ph3) gas. the heart,lungs, liver are the main targets in acute aluminum phosphide (alp) poisoning. most deaths occur due to cardiovascular toxicity.

aluminium phosphide is a potent respiratory chain enzyme inhibitor. its most important effect is the inhibition of cytochrome c oxidase. the inhibition of cytochrome c oxidase and other enzymes leads to the generation of superoxide radicals and cellular peroxides , and subsequent cellular injury through lipid peroxidation and other oxidant mechanisms. it stimulates the production of hydrogen peroxide and reactive oxygen species, malonyldialdehyde (mad), increases superoxide dismutase and inhibits catalase, peroxidase and glutathione . oxidative stress is one of the main mechanisms of action of aluminium phosphide toxicity

Eligibility criteria:
inclusion criteria: alp poisoned cases * admitted with free ecg exclusion criteria: concomitant ingesion of other drugs or toxins -

Keywords: tropinin ckmb cardiotoxicity
svp detection using machine learning

Conditions: Intracranial Pressure Increase

Summary: this diagnostic study will use 410 retrospectively captured fundal videos to develop ml systems that detect svps and quantify icp. the ground truth will be generated from the annotations of two independent, masked clinicians, with arbitration by an ophthalmology consultant in cases of disagreement.


Eligibility criteria:
inclusion criteria: * patients aged ≥18 years with presumed normal icp undergoing routine dilated oct scans. * patients undergoing a lp or continuous icp monitoring with implanted transcranial pressure transducer devices at in- or out-patient neurology, neurosurgery or neuro-ophthalmology services. exclusion criteria: * glaucoma diagnosis or glaucoma suspects in either eye. * bilateral restricted fundal view, e.g. advanced bilateral cataracts. * bilateral retinal vein or artery occlusion.
percentage of secondary prevention patients treated to their ldl-c targets

Conditions: Hyperlipidemias; Atherosclerosis; Coronary Heart Disease; Carotid Stenosis; Peripheral Vascular Diseases; Diabetes Mellitus

Summary: a cholesterol/lipid profile screening project of high risk patients with hyperlipidaemia (secondary prevention) who already receive cholesterol-lowering therapy. lipid profile and rate of patients who are treated to target (which is \<100mg/dl for patients with high risk and \<70mg/dl for patients at very high risk) are screened (office-based specialists). the doctors therapy decisions after the screening and possible reasons for these decisions will be documented. our aim is to evaluate dosing habits, to evaluate how many patients are treated to their ldl-c target and to underline the importance of treating patients to their cholesterol targets.


Eligibility criteria:
inclusion criteria: * secondary prevention patients with hyperlipidemia and atherosclerosis (coronary heart disease, carotid stenosis, pvd, etc.) and/or diabetes who already receive cholesterol-lowering therapy exclusion criteria: * patients who do not receive cholesterol-lowering therapy

Keywords: hyperlipidemia need-to-treat nis secondary prevention patients with hyperlipidemia and atherosclerosis (coronary heart disease, carotid stenosis, pvd, etc.) and/or diabetes
restorelle direct fix anterior and posterior (a&p) for female pelvic organ prolapse: a prospective post market study

Conditions: Pelvic Organ Prolapse (POP)

Summary: this is a prospective, multi-center study designed to assess the palpability of the restorelle direct fix a\&p mesh after vaginal reconstruction surgery.


Eligibility criteria:
inclusion criteria: * adult female at least 18 years of age * willing and able to provide written informed consent * diagnosed with clinically significant pelvic organ prolapse of stage 2 or higher as determined by pelvic organ prolapse quantification system (pop-q) requiring surgical intervention in the anterior and/or posterior compartment * willing and able to complete all follow-up visits and procedures indicated in the protocol exclusion criteria: * concurrent surgical treatment of pelvic organ prolapse using anything other than the restorelle direct fix a\&p * confirmed stage 2 or higher prolapse as determined by pop-q for a compartment that is not being repaired in the same procedure * previous pelvic organ prolapse repair using synthetic grafts * patients requiring a total hysterectomy (i.e. removal of the cervix) at the time of vaginal reconstruction * patients requiring a procedure for fecal incontinence (i.e.) anal sphincteroplasty) at the time of vaginal reconstruction * pregnant or a desire to become pregnant * previous radiation or other treatments for cancer in the pelvic area * immunosuppression and/or current systemic steroid user * on any anticoagulation therapy at the time of implant or with bleeding diathesis

Keywords: pop pelvic organ prolapse anterior prolapse posterior prolapse vaginal prolapse vaginal floor reconstruction
intraoperative confocal laser scanning microscopy with use of ai for optimized surgical excision of basal cell carcinoma

Conditions: Basal Cell Carcinoma

Summary: the aim is to use ai to assist surgeons in analyzing clsm tissue slide images obtained during bcc surgeries with the aim to integrate it in real time. we plan to use ai to analyze clsm images of bccs and distinguish between tumor tissue, inflammatory tissue, and non-tumor/non-inflammatory tissue. this approach would provide surgeons with real-time feedback and automated image analysis, leading to a more targeted and efficient approach to tissue analysis. by improving the accuracy and speed of tissue analysis, our proposal could ultimately improve operative patient outcomes and benefit healthcare professionals.


Eligibility criteria:
inclusion criteria: * patients with basal cell carcinoma exclusion criteria: * patient unable to consent
peripheral artery disease in vastmanland

Conditions: Peripheral Vascular Diseases; Heart Failure; Ventricular Dysfunction

Summary: the main purposes of this study are: * to describe the prevalence and degree of reduced left ventricular function and hypertrophy in patients with peripheral arterial disease in comparison to controls from the general population, * to evaluate factors of importance to left ventricular dysfunction and hypertrophy in patients with peripheral arterial disease, and * to assess the impact of cardiac function and left ventricular hypertrophy on long-term prognosis in patients with peripheral artery disease.

left ventricular dysfunction is often a consequence of coronary heart disease (chd). chd is prevalent among patients with peripheral artery disease. however, there is limited data regarding left ventricular morphology and function in those patients. in the cross-sectional part of this study we will describe the prevalence of reduced cardiac function and left ventricular hypertrophy in a cohort of patients with peripheral artery disease. the patient outcomes will be compared to control subjects randomly selected from the general population in a case-control design. further, clinical and genetic determinants of cardiac dysfunction in the patient cohort will be identified. in the longitudinal part of the study, the impact of cardiac function and morphology on cardiovascular mortality and morbidity will be evaluated in the cohort.

Eligibility criteria:
inclusion criteria: fulfillment of at least one of the following criteria: * ankle-brachial-index (abi) \<= 0.9, or * stenosis of \> 30% of the internal carotid artery, or * symptoms typical for claudication and corresponding stenotic findings on the ultrasound examination. exclusion criteria: * age less than 18 years * severly impaired communication capabilities

Keywords: cardiovascular diseases hypertrophy, left ventricle echocardiography prognosis
qctg and doppler ultrasound in the detection of hypoxia among fgr fetuses

Conditions: Late-onset Fetal Growth Restriction

Summary: to evaluate the benefits of combining doppler measurements of placental/fetal blood vessels with computerized cardiotocography (quantitative cardiotocogrpahy - qctg) in the detection of fetal hypoxia (ph \< 7.20) among late-onset growth restricted (sgr) fetuses


Eligibility criteria:
inclusion criteria: * estimated fetal weight below the 10th centile of the reference curve for the bulgarian population (11); * absence of sonographic and laboratory evidence of structural anomalies; * absence of severe maternal complications; * documented birth weight \< 10th centile; * full follow-up documentation exclusion criteria: * multiple pregnancies; * congenital malformations and any chromosomal malformations known before labor and delivery; * severe maternal complications; * documented birth weight \> 10th centile; * pregnancy loss; * failure to obtain full follow-up documentation
proteomics and radiomics research of breast cancer markers in tissue, interstitial fluid and serum

Conditions: Breast Cancer

Summary: the current study is a case control study involving comparisons of tissue interstitial fluid from breast cancer and adjacent non-cancerous tissue as well as that from benign breast lesion and its adjacent non-diseased tissue for a distinguishable breast cancer profile. the purpose of this research is to collect fresh breast nodule/cancer and surrounding non-cancerous tissue for proteomic studies of the interstitial fluid to identify a profile distinguishing breast cancer which will also permit future research on stored interstitial fluid, blood or tissue samples. specific markers identified from interstitial fluid study will be investigated in blood samples to develop serum markers for breast cancer diagnosis and prognosis. additionally, we will perform both prospective and retrospective research on breast cancer involving clinical, demographic, epidemiologic information, treatment, follow-up and outcomes on breast nodule/cancer cases collected.


Eligibility criteria:
inclusion criteria: * all subjects ≥ 18 years of age undergoing surgery for indeterminate breast nodules, breast tissue reduction, prophylactic mastectomy, and all subjects with newly diagnosed invasive breast cancer will be eligible to participate. if invasive breast cancer or suspicion of invasive breast cancer, target lesion must measure ≥ 1.0 cm on breast imaging before core biopsy. exclusion criteria: * anyone \< 18 years of age. * multiple synchronous primary malignancies from different organ systems.

Keywords: proteomics breast cancer markers tissue interstitial fluid
telepalliation - digital platform for patients in palliation and their relatives

Conditions: Cancer; Heart Failure; Chronic Obstructive Pulmonary Disease; Neurological Diseases

Summary: this project has focus on patients in palliation testing a digital platform telepal.dk.

the aim of the rct study is to: • test, implement, and evaluate a telepalliation program for patients receiving palliative care (cancer, heart failure (hf), copd, and motor neuron disease) from a clinical, psychosocial, inter-organizational, and health economic perspective.

Eligibility criteria:
inclusion criteria: * over 18 years * live in esbjerg, varde, billund, fanø or vejen municipality * cancer, heart failure, chronic obstructive pulmonary disease (copd), and motor neuron disease (neurological diseases) referred to the palliation team at southwest jutland hospital * basic computer skills or a relative who has basic computer skills exclusion criteria: * delirium at enrolment based on cam score * active psychiatric history (as noted in the medical record) other than depression or anxiety related to the main diagnosis referred to palliative care * lack of ability to cooperate

Keywords: palliative care palliation platform quality of life
electrolysis percutaneous therapeutic (epte) for supraspinatus tendinopathy

Conditions: Supraspinatus Tendinopathy

Summary: therapeutic management of supraspinatus tendinopathy is conflicting. there is evidence that eccentric exercise protocols can be effective for this condition. the inclusion of other therapeutic modalities could help to the management of these patients. a new therapeutic approach, called electrolysis percutaneous therapeutic (epte) has been clinically developed. the objective of this randomized clinical trial is to determine the effectiveness of the inclusion of epte into a eccentric exercise protocol for the management of patients with unilateral supraspinatus tendinopathy


Eligibility criteria:
inclusion criteria: * unilateral supraspinatus tendinopathy * shoulder pain from at least 3 months * shoulder pain of more than 4 points on a nprs * positive findings of supraspinatus tendinopathy on mri exclusion criteria: * bilateral shoulder symptoms * younger than 18 or older than 65 years * history of shoulder fractures or dislocation * cervical radiculopathy * previous interventions with steroid injections * fibromyalgia syndrome * previous history of shoulder or neck surgery * any type of intervention for the neck-shoulder area during the previous year

Keywords: supraspinatus, tendinopathy, pain, disability, epte
short message service (sms) impact on patient compliance receiving long term lipid lowering therapy with statins

Conditions: Dyslipidemia

Summary: the objective of the study is to determine whether short text massages could be used successfully as a compliance aid and improve clinical outcomes in long term lipid lowering therapy.

indication: patients discharged from the intensive cardiac care unit or the internal medicine department following acute coronary syndrome (acs) events such as unstable angina or acute myocardial infarction who will be prescribed a statin for the first time for preventing further coronary episodes. drug(s) and dose/regimen: regular or aggressive simvastatin therapy (dose will be adjusted according to ldl and total cholesterol levels). treatment period 6 months. objectives: to determine whether using sms technology can improve compliance and hence clinical outcomes in patients with long-term lipid lowering therapy. primary outcome: number of patients who achieve target ldl goals. secondary outcomes: reductions of total cholesterol, ldl, ldl/hdl and crp; increase of hdl; readmissions due to acs. study background/rationale/purpose: long-term lipid lowering therapy is the cornerstone of preventing recurrent cardiac events in patients that have experienced such episodes. numerous studies have demonstrated the efficacy of statins in the treatment of hyperlipidemia and reduction of total mortality, vascular mortality and coronary adverse events1. one of the main concerns affecting the success of long-term chronic drug treatments is patients' compliance and adherence to the prescribed regimen. till date there is no gold standard system that will assure complete patient compliance. it has been suggested to explore the possibility of using short messages service (sms) technology to improve patients' compliance 2-18. such technology may be effective in targeting this problem; however, no controlled trials have been conducted to validate this method in long-term lipid lowering treatments. furthermore, israel is one of the leading countries in terms of expansion of the mobile phone services market, making sms a feasible and effective form of communication with patients.

Eligibility criteria:
inclusion criteria: * patients discharged from the intensive cardiac care unit or the internal medicine department following acs who will be prescribed a statin for the first time for preventing further coronary episodes. * patients in the ages of 18-80. * patients who own mobile phone and are familiar with sms technology and are able to read hebrew text. exclusion criteria: * contra indication to study medication: active liver disease or elevated liver enzymes; hypersensitivity to simvastatin; pregnancy and lactation. developed myopathy/rhabodmyalisis during study period. * developed increase in transaminases greater than 3 times the upper limit of normal. * current lipid lowering treatment (statins or other).

Keywords: compliance chronic pharmacotherapy statins
comparison of pcle and eb in gastric lesion diagnosis

Conditions: Low Grade Intraepithelial Neoplasia; High Grade Intraepithelial Neoplasia; Early Gastric Cancer; Gastric Intraepithelial Neoplasia

Summary: this is a prospective multicenter comparative study, aiming to compare probe-based confocal laser endomicroscopy (pcle) and endoscopic biopsies in the diagnosis of the whole specific gastric lesion especially for distinguishing low grade intraepithelial neoplasia (lgin) from high grade intraepithelial neoplasia (hgin) and create an endoscopic image database for the follow-up research.

traditional endoscopic biopsies can only obtain limited tissues from the whole lesion and is invasive, while probe-based confocal laser endomicroscopy (pcle) can obtain images at a cellular level of the entire lesion area in real time and non-invasively. there were only single-center and small-sample previous researches for comparing the diagnostic accuracy of cle and traditional biopsy in the entire gastric lesions, and they did not distinguish gastric low grade intraepithelial neoplasia (lgin) from high grade intraepithelial neoplasia (hgin). thus, this study aims to further verify whether pcle or pcle combined with biopsy can improve the diagnostic accuracy of the overall lesion and reduce the histological upstaging rate of gastric lgin after endoscopic submucosal dissection (esd) by using large sample data and a new pcle classification method, so as to achieve better guidance of clinical treatment. while verifying the diagnostic efficacy of pcle, the data of the participants will be collected and collated, and an endoscopic image database will be constructed for the follow-up research.

Eligibility criteria:
inclusion criteria: * over 18 years old and under 75 years old; * patients with pathological diagnosis of lgin, hgin or early gastric cancer after conventional endoscopy biopsy, whose lesion has clear boundaries under endoscopic observation and is to be admitted for esd surgery; * patients who meet the indications for endoscopic resection of early gastric cancer, or lgin patients who intend to undergo esd surgery; * patients who are able to provide pathological specimens/sections of previous endoscopic biopsy (in principle, it should be a case of this center). exclusion criteria: * patients with advanced gastric cancer or previous gastrectomy; * patients with severe cardiopulmonary dysfunction, liver cirrhosis, renal dysfunction, acute gastrointestinal bleeding, esophageal-gastro varices, and coagulation disorders; * patients who have a positive result in the fluorescein sodium allergy test; * pregnant and lactating women; * patients who have psychiatric disorders and are unable to cooperate with endoscopy or sign informed consent.

Keywords: confocal laser endomicroscopy endoscopic biopsy intraepithelial neoplasia gastric cancer