Kornimate/medical-research-clean huggingface dataset:
cardiac and lung assessment of professional soccer players following covid-19 disease

Conditions: Covid19

Summary: during this world covid-19 outbreak, and according to the experience of team doctors, after their return, some players could have been affected by the sars-cov2. also, this study aims to clearly determine the condition of athletes at the end of lockdown after this covid-19 crisis and the cardiorespiratory consequences in particular in those who have been affected by covid-19 and the prevalence of acute myocarditis. the investigators assess in this observational study the cardiac and lung consequences of covid-19..

the global health crisis caused by the covid-19 virus, beginning in november 2019, initially in china, has being marked by a rapid spread, numerous severe respiratory cases and an elevated mortality rate. although that 85% on average of patients with sars-cov2 are not symptomatic or poor symptoms, these people were not systematically tested by pcr and spontaneously recovered. however, at the end of lockdown, the challenge for the medical staff in each first league soccer team involves to assess their clinical health conditions including clinical evaluation, covid-19 tests, chest ct, and cardiac function in order to detect potential anomalies. especially, physicians should be cautious about the risk of acute viral myocarditis, often asymptomatic, in patients having covid-19 with any or poor symptoms, reported in 7 to 28%. the risk could be a myocardial dysfunction, arrhythmic complications and/or sudden death during return to exercice. in this observational study, the investigators included the soccer player after the spring lockdown. after firstly an exhaustive interview to assess the lockdown quality of the athlete, clinical status and potential mild or poor symptoms of covid-19 during the outbreak, and secondly covid-19 serology and regular pcr tests. the athletes having a positive nasopharyngeal sars-cov2 pcr and/or positive covid-19 serology test, with or without symptoms, were included in the study. up to 10 days after first positive pcr, a cardiac evaluation is done including ekg, cardiac ultrasound echography and stress test in running ground and chest computer tomography (chest-ct). according to the results of cardiac tests and lung ct-scan, these athletes also require cardiac mri to eliminate the risk of acute myocarditis.

Eligibility criteria:
inclusion criteria: * professional soccer player * age over 18 years exclusion criteria: * recent muscle injury (\< 1 month) * recent orthopedic surgery (\< 3 months)

Keywords: covid19 athletes cardiac assessment lung ct-scanner covid19 cardiopulmonary consequences
quality of life in children glaucoma and cataract

Conditions: Paediatrics With Cataracts; Paediatrics With Glaucoma

Summary: the management of childhood glaucoma (cg), childhood cataract (cc) and other birth defects affecting the eyes requires frequent hospital attendances and often multiple surgical and medical interventions, and are often associated with poor vision. chronic medical conditions and vision impairment can affect quality of life (qol). the qol of children with the above conditions has not previously been evaluated.

we wish to evaluate health related and vision related quality of life (hrqol, vrqol) in children age 2 to 16 years with childhood glaucoma (cg), childhood cataract (cc) and congenital eye defects microphthalmia, anophthalmia or coloboma (mac). we will recruit children who attend the children's eye clinics at moorfields eye hospital at city road. we will include the following subgroups: a) children with primary or secondary glaucoma b) children with cataract or previously treated for cataract c) children with microphthalmia, anophthalmia or coloboma d) control group: agematched children without eye and vision problems. we will ask children and their carers to complete two age appropriate, validated questionnaires, the pedsql (health related quality of life) and the cardiff visual ability questionnaire for children. from the medical notes, we will record diagnosis and best corrected visual acuity with both eyes open. we will also record details of previous and current treatment, such as number of previous surgical interventions (sum of interventions right and left eye) and number of current topical medications (sum of eyedrop applications per day right and left eye).

Eligibility criteria:
inclusion criteria: a) children with primary or secondary glaucoma b) children with cataract or previously treated for cataract c) children with microphthalmia, anophthalmia or coloboma d) control group: age-matched children without eye and vision problems exclusion criteria: * ocular hypertension not requiring treatment; visually not significant cataract; inability to communicate in english; surgical intervention (incisional) within one month of potential date of completing questionnaire (before or after)
treating co-occurring substance use and mental disorders among jail inmates

Conditions: Co-occurring Mental and Substance Use Disorders; Crime; Criminogenic Thinking; Implementation; Adaptation

Summary: treatment adaptation and implementation study for adult jail inmates with co-occurring substance use disorders.

we will adapt dual-diagnosis motivational interviewing and integrated group therapy for jail inmates with co-occurring substance use and mental health disorders and to evaluate the feasibility of implementing the adapted interventions and associated research and communication protocols.

Eligibility criteria:
inclusion criteria: * (1) drug or alcohol abuse or dependence and smi (major depressive disorder; depressive disorder not otherwise specified \[nos\]; bipolar disorder i, ii, or nos; schizophrenia spectrum disorder; schizoaffective disorder; schizophreniform disorder; brief psychotic disorder; delusional disorder; or psychotic disorder nos); * (2) resident of wake county and detained in the jail; * (3) \>18 years of age; (4) able to speak/read english; and (5) able to provide informed consent. exclusion criteria: -

Keywords: jail co-occurring disorders implementation acceptability feasibility fidelity
aerobic interval training in cardiac rehabilitation

Conditions: Myocardial Infarction; Coronary Artery Disease

Summary: the purpose of the study is to compare home-based aerobic interval training with supervised interval training performed in groups or on a treadmill at the hospital.

cardiac rehabilitation is usually first offered in hospitals, but there are several studies that show that home-based rehabilitation is equally efficient. how this comes out when exercise is organized as aerobic interval training is not known.

Eligibility criteria:
inclusion criteria: * coronary artery disease * age over 18 * referred to cardiac rehabilitation * exercise tolerance demonstrated exclusion criteria: * severe arrhythmia * heart failure * drug abuse * pregnancy

Keywords: rehabilitation outcome cardiac patients exercise intensity
vasodilator-induced hypovolemia in living liver donors

Conditions: CVP and SVV During Living Donor Hepatectomy; Surgical Field Grade (Condition of Surgical Field; Bleeding, Tension of the IVC)

Summary: induced hypovolemia is known to improve surgical field during living donor hepatectomy. this procedure is conventionally guided by monitoring the central venous pressure (cvp). stroke volume variation (svv) is a novel method to substitute with cvp to monitor cardiac preload. the investigators try to evaluate the relationship between cvp and svv during cvp-guided vasodilator induced hypovolemia (validation study). then, feasibility of vasodilator induced hypovolemia using the svv calculated from the validation study will be tested (feasibility study).

this is a 2-phases study. first phase validation study : evaluation of the relationship between cvp and svv during cvp-guided vasodilator induced hypovolemia second phase feasibility study : comparison of the surgical field grade between validation study group(cvp guided group) and feasibility study group(svv guided group)

Eligibility criteria:
inclusion criteria: * adult (20-60 yr) * elective living liver donors exclusion criteria: * not obtained informed consent

Keywords: liver donor hepatectomy vasodilator central venous pressure stroke volume variation
investigation of gait pattern in idiopathic scoliosis

Conditions: Idiopathic Scoliosis

Summary: scoliosis is a condition characterized by an abnormal curvature of the spine, which can affect an individual's gait. scoliosis can alter body balance and weight distribution. pedobarographic analysis identifies imbalances and abnormal pressure points by measuring the distribution of pressure applied to the sole of the foot. this examination helps detect abnormalities in the gait mechanics of individuals with scoliosis. gait analysis can identify long-term foot and leg problems caused by scoliosis at an early stage, allowing for early interventions to prevent more serious issues. the aim of this study is to analyze gait in individuals with idiopathic scoliosis and compare it with that of healthy individuals. the study will include 30 scoliosis patients who visited the department of orthopedics and traumatology at gazi university hospital and were diagnosed with idiopathic scoliosis by a specialist physician. the gait patterns of the patients will be evaluated using pedobarography. information about the type and degree of scoliosis will be obtained from hospital records. the results of this study may provide an objective and detailed evaluation of gait and pressure distribution disorders in individuals with scoliosis and may contribute to more effective treatment plans.


Eligibility criteria:
inclusion criteria: * diagnosis of idiopathic scoliosis by an orthopedist * the cobb angle measured on the standard scoliosis radiograph should fall within the range of 10°-45°. exclusion criteria: * presence of any orthopedic or neurological disease affecting trunk and extremity mobility, excluding scoliosis. * history of previous spine or orthopedic surgery.
tivi evaluation of microcirculatory reactivity of the skin to galvanic stimulation: effect of aspirin

Conditions: Peripheral Arterial Disease

Summary: prospective interventional study. the aim is to analyze the effect of usual ongoing treatments over microvascular cutaneous response to galvanic current applications (civ: current induced vasodilatation) with tissue vitality (tivi) system on the forearm of subjects referred for ultrasound investigations due to suspicion of peripheral disease. hypothesis is that the use of aspirin (even at low dose) abolishes the response. this test could make it possible to detect the functional effects of low dose aspirin without using biological tests. a routine clinical application could be to use this civ to verify adherence to aspirin.

at admission eligible patients are proposed to participate. written consent is signed after complete oral and written explanation of the protocol is signed. no register of non-included patients will be kept. in included patients, in parallel to the routine ultrasound investigation for which the patient is referred, microvascular investigation will be performed as explained later in arm description. usual ongoing treatments are obtained by history and recorded. the end of the visit is the end of the participation of the subjects.

Eligibility criteria:
inclusion criteria: * subjects referred for investigation of peripheral arterial disease. * affiliation to the french national healthcare system * french speaking patients * ability to stand still for half a minute. exclusion criteria: * pregnancy * inability to understand the study goal * patients protected by decision of law
the impact of red packed cells transfusion on the main biological markers to determine the etiology of anemias

Conditions: Anemia

Summary: the aim of this work is to study the changes of key assays useful for the understanding of anemia mechanism before and after red packed cells transfusion: iron status, vitamin assays, hemolysis markers.

the aim of this work is to study the changes of key assays useful for the understanding of anemia mechanism before and after red packed cells transfusion: iron status, vitamin assays, hemolysis markers. the patient selection criteria are: * age \> or = 18 years * no history of transfusion \> or = 2 years * anemia (any etiology known or assumed) * decision of red packed cells transfusion for the current episode * transfusion performed at beaujon hospital * agreement of patient for the study number of subjects required: 100 patients study duration and duration of participation for each patient: * duration of the study: 1 year * for each patient the participation to the study began at baseline after the decision of transfusion and stopped at the second sample ie at least 72 hours after the transfusion of red blood cells. the maximum contribution for one patient is 5 days. methodology: it is a prospective non interventional monocentric (beaujon hospital) study. two blood tests will be performed; one before transfusion and the other from 48 to 72 hours after red packed cells transfusion. the following parameters will be measured before and after red packed cells transfusion: complete blood count (cbc) with reticulocyte count; complete iron status (ferritin, serum iron, transferrin, transferrin saturation), soluble transferrin receptor; serum and intraerythrocytic folate levels, vitamin b12; lactate dehydrogenase (ldh), bilirubin (total and free), haptoglobin, orosomucoid, direct coombs test; creatinine; crp. the aim of this work is to study the changes of key assays useful for the understanding of anemia mechanism before and after red packed cells transfusion: iron status, vitamin assays, hemolysis markers.

Eligibility criteria:
inclusion criteria: * age \> or = 18 years * no history of transfusion \> or = 2 years * anemia (any etiology known or assumed) * decision of red packed cells transfusion for the current episode * transfusion performed at beaujon hospital * agreement of patient for the study exclusion criteria: * patient who received between the 2 samples, a treatment which can modify the parameters evaluated (iron, vitamin)

Keywords: anemia transfusion biological markers
efficacy of 311-nm ti:sapphire laser versus 308-nm excimer laser treatment in vitiligo

Conditions: Vitiligo

Summary: a randomized controlled non-inferiority trial based on split-body was planned to compare the efficacy of 308-nm excimer laser and 311-nm ti:sapphire laser in patients with vitiligo.

the 308-nm excimer laser (el) has been widely used for localized vitiligo. recently, the 311-nm ti:sapphire laser (tsl) was developed to treat patients with vitiligo. to compare the efficacy of tsl vs. el in the treatment of vitiligo. a randomized controlled non-inferiority trial based on split-body was planned. the paired symmetric vitiliginous lesions will be randomized to either tsl or el treatment groups. all lesions will be treated twice weekly for a total of 12-week period. the degree of repigmentation will be assessed as % from baseline by using a computer program every 4 weeks, and the non-inferiority margin was set at 10%. overall 16 patients will be enrolled.

Eligibility criteria:
inclusion criteria: * age: older than 19 * a patient with stable non-segmental vitiligo * a patient with symmetrical vitiligo lesions * a patient with the willingness to comply with the study protocol during the study period and capable of complying with it * a patient who signed the informed consent prior to the participation of the study and who understands that he/she has a right to withdrawal from participation in the study at any time without any disadvantages exclusion criteria: * age: lower than 20 * a pregnant or lactating patient * a patient with active or spreading vitiligo * a patient who cannot understand the study or who does not sign the informed consent
efficacy/safety study of amaryl®m 1/500 mg twice daily versus amaryl® 4 mg both in combination with lantus® in type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus

Summary: the purpose of this study is to compare the efficacy of amaryl®m 1/500 mg twice daily versus amaryl® 4 mg both in combination with lantus® once-daily regimen in type 2 diabetes mellitus patients with inadequate glycemic control.

there are several kinds of oral antidiabetic drugs (oads) that are used in the treatment of patients with type 2 dm. among them, sulfonylurea and metformin are well-established first-line oads. however, as the beta cell dysfunction progresses over time, patients fail to achieve good glycemic control with oads alone and need further treatment intensification, usually involving the introduction of insulin either alone or in combination with oads. now, an oad combined with bedtime insulin is one of the recommended treatment options for patients with type 2 dm and oad failure. but, it still remains unclear which oads are the most effective in combination with insulin for the treatment of type 2 dm. so, this study we will be able to verify which oads are the most effective in combination with insulin for the treatment of type 2 dm.

Eligibility criteria:
inclusion criteria: * patients over 20 years old with type 2 dm * patients with inadequate glycemic control despite continuous use of tolerable or maximal doses of one or more oads for 3months or more. * 7%\<hba1c\<11 % at screening * 21 kg/m2 ≤ bmi ≤ 30 kg/m2 * patents who need insulin add-on therapy based on investigator's discretion * patients who would give the informed consent * patients who can perform smbg and record the data on the patient's diary exclusion criteria: * history of acute metabolic complications such as diabetic ketoacidosis or hyperosmolar nonketotic coma within 3 months before screening * pregnant or lactating females * history of drug or alcohol abuse * patients with known hypersensitivity to glimepiride, metformin hcl or insulin * night-shift workers * patients who are under insulin therapy at screening * treatment with any investigational products in the last 3 months before screening * clinically significant laboratory abnormality on screening labs or any medical condition that would affect the completion or outcome of the study based on investigator's decision * patients with serum creatinine level \> 1.5 mg/dl in male and \> 1.4 mg/dl in female * patients with alt or ast \> 3x uln

Keywords: type 2 diabetes mellitus
diet modification and blood pressure in young people

Conditions: Cardiovascular Diseases; Heart Diseases

Summary: to determine the effects of diet modification on blood pressure, blood cholesterol, and bone density in healthy young people.

background: an inadequate dietary intake of calcium has been postulated to be a factor in the development of essential hypertension, and has long been considered important in the development of osteoporosis among women. furthermore, animal experiments and limited studies in humans suggest that an increase in the intake of calcium may also have a beneficial effect on blood cholesterol levels. despite limitations in the research data supporting its benefits, increased calcium intake is being widely advocated to the public and calcium-enriched products are being increasingly purchased and consumed by americans. the study measured the effects of a modest increase in calcium intake, such as that currently advocated to the general public. previous work in the study measured the effects on blood pressures of variations in the dietary intake of sodium and linoleic acid in adolescents at the two new england boarding schools of phillips exeter academy and phillips andover academy. during the first year, dining room food at one school was prepared with 50 percent less sodium; total intake of sodium by students including dining hall food, outside food and snacks was reduced by approximately 35 percent. the other school served as the control. during the second year, the intervention took place at the second school. during the third and fourth years, sodium intake was kept at usual levels while changes were made in food preparation to double the polyunsaturated fatty acid intake from four percent to eight percent of dietary calories. food diaries, duplicate food samples, and 24-hour urine collections by approximately 200 students at each school were used to monitor dietary modification and student compliance. weekly blood pressure measurements were performed on the 200 students at each school. design narrative: a number of food products were modified to increase the dietary intake of calcium by an average of 500 mg/day. calcium-enriched foods were served alternately for one school year at each of two colleges. similar products without added calcium were served during the alternate year. it was postulated that, at the end of the school year, students at the intervention school would have lower systolic blood pressure, lower blood cholesterol, and increased bone density than students at the control school. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria
duration of prone position in the severe acute respiratory syndrome coronavirus 2 (covid-19).

Conditions: Ards

Summary: the omelette study is a randomised, controlled, unicentric, open-label study to prove the noninferiority of reduced prone position (pp) sessions (more tan 16 hours) versus prolonged pp (48 hours).

this is a non-comercial, investigator-driven clinical study developed in a single critical care unit. the study is coordinated by the main investigator from hospital universitario 12 de octubre in madrid; the sponsorship is performed by dr. ignacio sáez (hospital universitario 12 de octubre). the study was planned according to the good clinical practices. omelette study has been approved by the ethics committee. all participating patients must give informed consent before any study procedure occur.

Eligibility criteria:
inclusion criteria: * patient above 18 year-old. * diagnosis of severe ards due to covid-19 under invasive mechanical ventilation, * meet criteria for pp: pao2/fio2 \< 150 millimeters of mercury column (mmhg), peep ≥ 5 centimeters of water (cmh2o), fio2 ≥ 60. exclusion criteria: * no consent for the study. * pp contraindicated (( elevated intracranial pressure, massive hemoptysis, recent tracheal surgery or sternotomy, unstable hemodynamic status, recent pacemaker implantation, severe facial laceration, open abdominal wound, spine, femur or pelvis fracture or pregnancy).

Keywords: prone position mechanical ventilation oxygenation