Kornimate/medical-research-clean huggingface dataset:
detection of tumor associated cell-free dna in peritoneal fluid obtained by culdocentesis

Conditions: Stage III Ovarian Cancer; Stage IV Ovarian Cancer

Summary: this research study is studying a possible test which may help doctors diagnose women with ovarian cancer.

this research study is a feasibility study, to try to evaluate whether or not culdocentesis can detect tumor associated cell free dna. although this is the first time investigators are using this type of procedure to detect cell free dna, culdocentesis is not a new procedure. it used to be done routinely in the past to examine pelvic fluid. the investigator's goal is to develop a test to detect ovarian cancer in women before they develop any signs or symptoms of the disease. currently, there is no screening test for ovarian cancer. this study uses a technique called "culdocentesis" to detect dna released by ovarian cancer cells into pelvic fluid. during culdocentesis, a small needle is inserted through the vagina into an empty space between the uterus and the rectum called the "cul-de-sac." fluid is withdrawn from this space and sent for analysis. culdocentesis is a technique that has been used for many years to examine pelvic fluid and determine its composition, but it has not previously been studied as a technique for examining cell-free dna to detect ovarian cancer. the investigators suspect that this may be a useful way to detect cell-free dna from ovarian cancer cells because the ovaries are very close to the cul-de-sac space. in this study, the investigators will compare our ability to detect cell-free dna in fluid from the cul-de-sac with our ability to detect cell-free dna from a vaginal swab (similar to a pap smear), a blood test, and in the tissue specimens collected at the time of surgery. the investigators are hoping to learn from this study whether developing a cell-free dna test to screen for ovarian cancer involving culdocentesis would be an effective strategy.

Eligibility criteria:
inclusion criteria: * female * age ≥ 18 * able to give informed consent * scheduled for surgery at brigham and women's hospital for known or highly suspected stage iii or iv ovarian cancer (i.e. elevated ca-125 with a pelvic mass, ascites, and carcinomatosis) * post-menopausal or negative urine and/or blood pregnancy test * measurable disease on preoperative imaging exclusion criteria: * male * age \< 18 * unable to give informed consent * not planned for surgical intervention * active malignancy other than ovarian cancer * prior bilateral tubal ligation or hysterectomy (as this would prevent chromopertubation) * known or suspected active pelvic infection * pregnancy * no measurable disease or suspected stage i or ii ovarian cancer on preoperative imaging

Keywords: stage iii ovarian cancer stage iv ovarian cancer
open-label, phase 2, proof of concept study in multiple myeloma - denosumab

Conditions: Relapsed or Plateau-Phase Multiple Myeloma

Summary: the purpose of this study is to determine if denosumab is effective in the treatment of relapsed or plateau-phase multiple myeloma.

patients who have relapsed myeloma have failed treatment regimens and have had disease progression following their last treatment regimen. despite newer salvage therapies, their treatment options are limited and may include best supportive care and investigational therapy. patients with plateau-phase myeloma have a stabilized serum m-protein level without further tumor regression despite continued treatment. recent evidence suggests that their prognosis might improve with further reduction in serum m-protein or prolongation of time to disease progression (ttp). these patients are candidates for investigational agents that could further reduce tumor burden or increase ttp.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * clinical diagnosis of relapsed or plateau-phase multiple myeloma * measurable disease (\>0.5 g/dl) as determined by special blood tests * ecog 0 or 1 exclusion criteria: * newly diagnosed myeloma * non-secretory myeloma * plasma cell leukemia or plasma cell dyscrasia with poems syndrome * prior allogeneic stem cell transplant * administration of oral or iv bisphosphonates within 2 weeks of enrollment to study other criteria also apply.

Keywords: multiple myeloma, relapsed, plateau-phase
electro-clinical features and functional connectivity analysis in syn1 gene mutation-related epilepsy

Conditions: Epileptic Syndromes

Summary: syn1 gene mutation is an x-linked gene mutation that causes numerous pathological manifestations such as seizures and neurodevelopmental disorders. a few descriptions of this disease have been published in the last decade, but the electro-clinical features of epilepsy are still largely unknown. no analysis of electroencephalographic connectivity has yet been performed. the aim of this study is to perform a detailed electro-clinical seizure analysis and electroencephalographic analysis in patients with a syn1 gene mutation, in an attempt to identify a characteristic pattern that would allow earlier diagnosis and better understanding and management of this disease.


Eligibility criteria:
inclusion criteria: * cases : syn1 gene mutation, available electroencephalographic and clinical data. * controls : older than 12 years at the moment of the electroencephalogram recording, electroencephalogram considered as normal, no neurological disease (particularly no epilepsy), no neuroimaging abnormality. exclusion criteria: - controls : younger than 12 years at the moment of the electroencephalogram recording, electroencephalogram considered as abnormal, neurological disease (particularly epilepsy), neuroimaging abnormality.

Keywords: syn1 mutation reflex bathing epilepsy neurodevelopmental disorders connectivity analysis electro-encephalographic seizure pattern
impact of an integrated obesity management system on patient's care

Conditions: Obesity

Summary: the investigators developed a program aimed at enhancing primary care physician (pcp) teams' expertise, self-efficacy and attitudes with respect to obesity management. the investigators implemented and evaluated this obesity management system based on a preceptorship combined with a virtual learning community favouring continuous support of family medicine groups (fmgs, groupes de médecine familiale) by a team of experts in obesity management; significant improvements regarding their attitudes and perception of self-efficacy were observed immediately after the preceptorship and maintained after one year. furthermore, the investigators observed significant changes in their practice that were maintained one year later. the investigators hypothesize that their program combining preceptorships with a virtual community will improve: (1) management and weight loss of obese/overweight subjects who are treated by pcps for hypertension (htn), type 2 diabetes (dm2) or impaired glucose tolerance (igt); and (2) screening and initial management of obesity among unselected patients of pcps who practice in fmgs.


Eligibility criteria:
inclusion criteria: * patients who have, during the past 2 years, at least 4 documented visits for the targeted diseases group and at least 2 visits for the regular follow-up group exclusion criteria: * active mental health problem * active psychiatric disorder * cancer in the last five years * patient with medication that changed in the last 6 months
kinesiology taping in duchenne muscular dystrophy: effects on performance, gait characteristics, and energy consumption

Conditions: Performance; Energy; Gait; Duchenne Muscular Dystrophy

Summary: investigators investigated that the effects of kinesilogy taping on performance, energy consumption and gait characteristics in patients with duchenne muscular dystrophy

forty-five patients from level 1 and 2 according to the brooke lower extremity functional classification were included in the study. performance was assessed by measuring the distance in 6-minute walk test (6mwt) and the duration of timed performance tests; energy consumption by physiological consumption index (pci), and gait characteristics by footprint method on powdered ground at baseline. kinesiology taping with facilitation technique was applied on bilateral quadriceps and tibialis anterior muscles and the assessments were repeated 1 hour after application. the comparison between before and after taping was analyzed.

Eligibility criteria:
inclusion criteria: * duchenne muscular dystrophy diagnosis, * age 5 to 14 years, * able to cooperate with instructions of physiotherapist, * able to walk independently, * climb 4 steps independently/with minimal support from handrails. exclusion criteria: * severe contracture at lower extremities, * other disease except for dmd, and * history of any injury or orthopaedic/neurologic surgery within the past 6 months.

Keywords: kinesiology taping performance energy consumption gait duchenne muscular dystrophy
middle meningeal artery embolization for patients with chronic subdural hematoma

Conditions: Endovascular Treatment; Chronic Subdural Hematoma

Summary: complement study (chronic subdural hematoma patients supplemented with embolization of middle meningeal artery trial) is a prospective, open label, blinded endpoint (probe), japanese, two-arm, randomized, controlled, post-market study to assess the efficacy and safety of middle meningeal artery embolization for chronic subdural hematoma.


Eligibility criteria:
inclusion criteria: 1. age \>=18 2. pre-mrs 0-3 3. hematoma thickness \>=10mm 4. having at least one risk factor risk factor: age \>=75, antithrombotic therapy, dm, bilateral hematoma, markwalder grading score \>3, preoperative volume \>=130ml, preoperative midline shift \>=8mm, ct appearance (homogeneous, laminar or separated) exclusion criteria: 1. cr \>=1.8 2. plt \ 2 3. life expectancy \<6 months
contralateral restor / monofocal or phakic eye

Conditions: Cataracts

Summary: bilateral evaluation of unilateral implantation of restor and contralateral monofocal or phakic eye.


Eligibility criteria:
inclusion criteria: * unilateral operable cataract * candidate for presbyopic intraocular lens (iol) exclusion criteria: * ocular comorbidities compromising primary outcome * bilateral cataracts

Keywords: acrysof restor multifocal intraocular lens
microrna-126 and its target vcam-1dermatitis to nickel

Conditions: Allergic Contact Dermatitis

Summary: background. allergic contact dermatitis (acd) is an inflammatory skin disease mediated by direct contact with allergens as nickel, the most common allergen, that may be related with epigenetic changes. objective. evaluate the mir-126 expression and its target vcam-1, in the skin of patients with acd to nickel. methods. fifteen patients with positive patch test to nickel were included, and the expression of mir-126 and vcam-1 was evaluated by rt-qpcr.

patients that went to the dermatology and outpatient department of the central hospital "dr. ignacio morones prieto ", with a suspected diagnosis of nickel allergic contact dermatitis, were invited to participate in this study. later, the objective and methodology of the study were explained to them, as well as the advantages of participating and the possible undesirable effects. all patients signed the informed consent previous perfom the medical history. after, the epicutaneous patch test was performed, and patients were divided according to the result them. finally, under local anesthesia, two 3-mm punch biopsies, from lesional (positive parch test site) and adjacent non lesional skin, 10 cm apart, were performed. tissues for reverse transcriptase real-time polymerase chain reaction (rt-qpcr) analyses were stored frozen in sterile tubes at 80ºc until processing

Eligibility criteria:
inclusion criteria: * 18 years of age and older * epicutaneous patch test positive to nickel * without previous treatment within the previous 4 weeks exclusion criteria: * pregnancy * nursing * menopause * consumption of any type of drugs (including anti-inflammatories and hormonal treatments) within the previous 2 months * coexistence of other dermatoses conditions

Keywords: allergic contact dermatitis nickel micrornas vcam-1
thrombembolism after robot- assisted surgery in urology

Conditions: Urologic Cancer; Thrombosis; Embolism; Surgery--Complications

Summary: cancer patients have an increased risk of perioperative complications undergoing surgery procedures. postoperative complications caused by thrombembolic events after robot- assisted surgery in major urological procedures have been reported and associated with an increased lenght of stay in the hospital. we therefore aimed to investigate in a retrospective analysis 250 patients undergoing robotic-assisted radical cystectomy and prostatectomy procedures for risk factors for thrombembolic events in this specific patient population.

postoperative arterial or venous thrombembolism after robotic- assisted surgery in major urological procedures are reported severe complications in this patient population. after having studied the available literature on this particular topic the investigators have decided to prepare a retrospective analysis of approximately 250 robot- assisted radical cystectomy and radical prostatectomy surgical procedures. in due consideration of perioperative prophylaxis of thrombembolic events we determine the clinical and radiological signs of venous or arterial thrombembolism postoperatively with a particular focus on early postoperative pulmonary embolism events. this is a retrospective analysis of 250 robotic-assisted radical cystectomy and radical prostatectomy surgical procedures.

Eligibility criteria:
inclusion criteria: * over 18 years of age * scheduled for urological surgery (cystectomy and/or prostatectomy) * signed basical declaration of consent exclusion criteria: * absent or unsigned basical declaration of consent

Keywords: thrombembolism after robot-assisted surgery
emotion regulation therapy for clinical worry and rumination

Conditions: Anxiety Disorders and Symptoms; Depression, Anxiety; Generalized Anxiety Disorder; Emotional Dysfunction

Summary: the present project aims to broaden our understanding of neural mechanisms which may underlie change in symptoms occurring over the course of emotion regulation therapy. specifically, we aim to examine neural changes as a result of either an 8-session or 16-session version of the treatment.

this study aims to examine the utility of emotion regulation training (ert) in reducing symptoms of anxiety and/or depression in young adults aged 18 to 29 years old. additionally, we are interested in assessing neural, cardiac, and immunological changes associated with psychological symptom reduction in these individuals. lastly, we are interested in examining whether an abbreviated 8-session version of ert produces similar results to a longer (16-session) version of ert.

Eligibility criteria:
inclusion criteria: * aged 18-29 years during the time of participation * meets diagnostic criteria for an anxiety and/or depressive disorder * endorses significant worry and/or rumination exclusion criteria: * active suicidal intent * current substance dependence disorder (within the past year) * current or past psychotic disorder, bipolar-i disorder, or dementia * not currently received any other form of psychosocial treatment * not being on a stabilized dose of medication (less than 3 months) during enrollment * pregnancy or plans to become pregnant during active participation * irremovable metal objects in the body * neurological disorder, traumatic brain injury, or loss of consciousness * tattoos if/when posing risks for involvement in the mri component of the study

Keywords: emotion regulation distress disorders anxiety depression
the use of electrical stimulation by capacitive field in the repair of skin burns and quality of life

Conditions: Burns; Wound Healing

Summary: the high incidence of burn injuries and mortality and morbidity as well as the high economic impact associated with this type of injury justifying the need to develop new technologies for the treatment of burn patients. electrical stimulation for wound healing is a resource that has been increasingly used in routine physical therapists, but has the disadvantage of needing means of wet contact between the electrode and injury. the other resource used for therapeutic healing is conventional electrical stimulation of low intensity for capacitive field, a technique of physical therapy intervention not commercially available in brazil. this new technology seems to have significant physiological effects in tissue repair and has been used for the treatment of chronic wounds which healed with difficulty. the objective is to analyze the effects of electrical stimulation of low intensity for capacitive field in healing skin burns. patients from both genders aged over 18 years who have burns, will be evaluated and treated at the emergency unit of the hospital of the faculty of medicine of ribeirão preto, university of são paulo. the stimulation will be initiated within 24 hours after surgery to perform the graft and will be held daily for 60 minutes during the patient's stay or until complete healing of the skin. the electromagnetic field will be placed on the care of the burned area and / or the donor skin graft, not interfering with departmental procedures. will be performed photographic record standardized wound by a digital camera, and then quantified by a computer program. expected to reduce the period of hospitalization and thus lowering the cost of treatment, and the possibility of improving the quality of life of patients.


Eligibility criteria:
inclusion criteria: * all patients admitted to the burns unit of clinical hospital, faculty of medicine of ribeirão preto / usp, in the period between september 2014 and june/2013. * greater than 18 years. * deep acute burn requiring excision and grafting exclusion criteria: * patients who use medicines that may interfere with the process of tissue repair. * body mass index less than 16 kg / m² * older than 65 years

Keywords: burns wound healing magnetic field therapy
the pathfinder study: a feasibility trial

Conditions: Coronary Artery Disease; Delirium

Summary: the main purpose of this study is to determine whether a rational strategy of eeg guided multimodal general anesthesia using target specific sedative and analgesics could result in enhanced recovery after anesthesia and surgery, decrease in postoperative delirium, and decrease in long term postoperative cognitive dysfunction up to 6 months following cardiac surgery.

the main purpose of this study is to determine whether a rational strategy of eeg guided multimodal general anesthesia using target specific sedative and analgesics could result in enhanced recovery after anesthesia and surgery, decrease in postoperative delirium, and decrease in long term postoperative cognitive dysfunction up to 6 months following cardiac surgery. specific aim 1: the feasibility of implementing multimodal general anesthesia strategy in the operating rooms (or) specific aim 2: the feasibility of implementing eeg guided sedation until extubation in the intensive care unit (icu) specific aim 3: the enhancement of recovery after surgery (shorter ventilation time, icu stay, hospital length of stay) specific aim 4: to estimate the effect size of decrease in postoperative day (pod) and postoperative cognitive dysfunction (pocd) to power future large randomized trials

Eligibility criteria:
inclusion criteria: 1. age ≥ 60 years 2. undergoing any of the following types of surgery with cardiopulmonary bypass limited to coronary artery bypass surgery (cabg), cabg+valve surgeries and isolated valve surgeries. exclusion criteria: 1. preoperative left ventricular ejection fraction (lvef) \<30% 2. emergent surgery 3. non-english speaking 4. cognitive impairment as defined by total moca score \< 10 5. currently enrolled in another interventional study that could impact the primary outcome, as determined by the pi 6. significant visual impairment 7. chronic opioid use for chronic pain conditions with tolerance (total dose of an opioid at or more than 30 mg morphine equivalent for more than one month within the past year) 8. hypersensitivity to any of the study medications 9. known history of alcohol (\> 2 drinks per day) or drug abuse active (in the past year) history of alcohol abuse (≥5 drinks/day for men or ≥4 drinks/day for women) as determined by reviewing medical record and history given by the patient 10. liver dysfunction (liver enzymes \> 4 times the baseline, all patients will have a baseline liver function test evaluation), history and examination suggestive of jaundice.

Keywords: cardiopulmonary bypass cardiac surgery analgesics
computer-based online database of acute stroke patients for stroke management quality evaluation

Conditions: Stroke, Acute

Summary: in the past three decades, the burden of stroke has increased in china and has gradually become the leading cause of death. the data acquisition and medical quality management still need to be improved in china. the purpose of this study was to establish online database of acute stroke patients for stroke management quality evaluation in china.

this study is a prospective multi-center registration study. the data of acute ischemic stroke patients who underwent reperfusion therapy were registered on emergency platform. the data of stroke patients who were hospitalized were registered on stroke meidical quality control platform. the information including demographics, risk factors (history of hypertension, diabetes, stroke/tia or atrial fibrillation, etc), prior antiplatelet usage, onset to door time (odt), baseline national institutes of health stroke scale (nihss) score, baseline infarct core volume, laboratory data, ect were recorded. clinical outcome at 3 months and 1 year was assessed.

Eligibility criteria:
inclusion criteria: acute stroke patients exclusion criteria: no

Keywords: thrombolysis thrombectomy hospitalization