Kornimate/medical-research-clean huggingface dataset:
variability analysis during weaning and extubation in critically ill patients

Conditions: Critical Illness

Summary: for critically ill patients, it is important to know when to liberate them from mechanical ventilation (the removal of breathing or endotracheal tube or extubation) and weaning (the progressive decrease of the amount of support that a patient receives from the mechanical ventilation). it is well recognized that prolonged ventilation and weaning harms patients and introduces significant increased costs to the health care system. the investigators objective is to improve the safety of removal of life support in critically ill patients by harnessing information from two new technologies; nm3 and nexus device. in particular, the investigators are interested in the patterns of variation of respiratory and cardiac signals from the nm3 device, as well as monitor skin conductance with the nexus device. the combination of these measures has not yet been investigated to date, and could represent a novel set of measures that can be used to help physicians better manage critically ill patients. the current standard of care dictates that once a patient is considered as a candidate for withdrawal from ventilation, a spontaneous breathing trial (sbts) is performed, where the degree of ventilator support is decreased, and their response is observed to help predict if they will tolerate extubation. health is associated with a high degree of variation of physiologic parameters such as heart rate and respiratory rate, and illness \& stress are associated with a loss of variability. the analysis of variability of biological signals measures the degree of fluctuations present over time. previous studies have demonstrated that changes in variability (generally decreases) are observed in illness states, and the degree of this change correlates with illness severity. several studies have reported that reduced heart or respiratory rate variability (hrv or rrv) during sbts is associated with extubation failure. until recently, variability analysis has traditionally been done only on heart rate (hrv), derived from analyzing beat-to-beat intervals from the ubiquitous electrocardiogram (ecg). the investigators aim to apply variability analysis to the respiratory and cardiac signals which represent a rich novel set of muti-organ variability measures whose utility in managing extubation and ventilator weaning has not been investigated to date.


Eligibility criteria:
inclusion criteria: * respiratory failure * cardiac failure * consent within 48 hours of admission to the icu exclusion criteria: * allergy to skin adhesives * on study less than 72 hours

Keywords: respiratory monitoring cardiac monitoring skin conductance monitoring variability
remogen® omega versus cationorm® in the treatment of patients suffering from dry eye

Conditions: Dry Eye

Summary: the efficacy and safety of remogen® omega in the treatment of dry eye signs and symptoms will be investigated in comparison to cationorm®.


Eligibility criteria:
inclusion criteria: * with at least a 3-month documented history of bilateral dry eye * with a score of ocular surface staining with fluorescein (ossf) ≥ 4 and ≤ 9 on the oxford scale * with at least one objective sign of tear deficiency * with ocular surface disease index (osdi) score of ≥ 18 exclusion criteria: * refractive surgery within 12 months prior to selection * any other ocular surgery or ocular trauma within 6 months prior to selection * systemic or local use of one of the following medications: glucocorticosteroids, cyclosporine a, antibiotics, nsaids
examining the effects of art therapy in reducing burnout in healthcare providers

Conditions: Burnout, Professional

Summary: in this study, the investigators aim to examine the effects of art therapy in reducing burnout in healthcare providers. using the maslach burnout inventory human services survey for medical personnel, the investigators will measure burnout in medical university of south carolina (musc) providers before and after the administration of a 4-week art therapy group.


Eligibility criteria:
inclusion criteria: * age: 18 years or older * employed at musc as a healthcare provider * able and willing to participate in all 4 art therapy sessions exclusion criteria: * individual does not provide direct patient care at musc * individual works in the same department as the art therapist * inability or unwillingness of subject to give informed consent

Keywords: art therapy
moving together: an online group movement program for people living with memory loss and caregivers

Conditions: Alzheimer Disease; Dementia

Summary: to determine whether moving together improves quality of life in people with memory loss (pwml) and caregivers (cg) by performing a randomized, controlled trial (rct) with a waitlist control group in 224 dyads.

the investigators will perform an rct with a 12-week delayed start control group in 224 dyads of pwmls and cgs. the primary outcome in pwml will be self-rated quality of life (quality of life in alzheimer's disease, qol-ad). secondary outcomes will include: a) self-reported emotional well-being; b) self-reported social isolation; c) self-reported mobility; and d) directly assess cognitive performance. in cgs, the primary outcome will be self-rated quality of life (sf-12). secondary outcomes in cgs will include: a) healthy days; b) self-efficacy; c) burden; d) social isolation; e) ability to self-regulate; f) positive affect; and g) sleep quality. in addition, the investigators will ask cgs to report sleep quality, mobility, and cognitive function for pwml. additional exploratory outcomes will include health services utilization (hospitalizations, emergency department visits) and falls. in addition to the rct, the investigators propose to compare health utilization outcomes in study participants to a matched 'no contact' comparison sample of patients with dementia diagnoses who receive care in the university of california san francisco (ucsf) health system.

Eligibility criteria:
inclusion criteria: * people with memory loss (pwml): * u.s. resident; * english language fluency; * diagnosis of alzheimer's disease or other dementia; mild severity, assessed using the quick dementia rating system. * caregivers (cg): * u.s. resident; * english language fluency; * primary caregiver for pwml; * own one or more devices that can be used to participate in two-way livestreaming video classes (e.g., smart phone/tablet + tv, laptop or desktop with webcam, smart tv); * willing and able to participate in two-way livestreaming group movement classes with person with pwml. exclusion criteria: * age \< 18 years; * primarily use wheelchair inside home; * limited life expectancy (e.g., enrolled in hospice, meta-static cancer); * physical limitations that could affect ability to participate (e.g., difficulty sitting for 1 hour, chronic pain, vertigo); * severe visual impairment (e.g., unable to observe instructor's movements on screen); * severe hearing impairment (e.g., unable to hear instructor's requests); * behavioral or psychiatric issues that could be disruptive in group setting (e.g., history of physical or verbal abuse, schizophrenia, bipolar disorder, substance abuse); * unable to provide consent/assent; * planning to travel for \>1 week during initial 12-week study period.
national study on the quality of life of patients with anorectal malformation

Conditions: Anorectal Malformation

Summary: anorectal malformations, occurring approximately 1 in 5000 live births, mainly involve the distal anus and rectum, but also sometimes the urinary and genital tracts. defects range from the minor and easily treated with an excellent functional prognosis, to those that are complex and often associated with a poor functional prognosis. despite the better knowledge of the anatomy and physiology and the improvement of surgical management after birth, fecal and urinary incontinence can occur, due mainly to deficient nerve supply. the quality of life of such patients is largely unknown in this country. the aim of the investigators study is to propose specific and generic questionnaires to the patients registered in the national database, correlated to their anatomical and functional status. a better understanding of such correlations should allow improvements in their medical and social management.

anorectal malformations (arm), occurring approximately 1 in 5000 live births, mainly involve the distal anus and rectum, but also sometimes the urinary and genital tracts. defects range from the minor and easily treated with an excellent functional prognosis, to those that are complex and often associated with a poor functional prognosis. despite the better knowledge of the anatomy and physiology and the improvement of surgical management after birth, fecal and urinary incontinence can occur, due mainly to deficient nerve supply. a few studies and clinical practice have shown that disease-specific problems of arm have an effect on somatic function, mental health and psychosocial functioning. the assessment of quality of life requires a self-report questionnaire composed of items related to physical, emotional and social functioning, and disease-related symptoms. a specific arm questionnaire, the haql, was developed by a dutch team and published in 2001. associated with generic questionnaire, it allowed quality of life assessment in dutch population. the quality of life of such patients is largely unknown in this larger country. the aim of the investigators study is to propose specific (haql translated from dutch to french) and generic questionnaires to the patients registered in the national database, correlated to their anatomical and functional status. a better understanding of such correlations should allow improvements in their medical and social management.

Eligibility criteria:
inclusion criteria: * patients who are between 6 and 30 years old * patients initially treated in a french pediatric surgery service for anorectal malformation exclusion criteria: * patients lost from sight or dead * patients with concomitant malformations that can modify sphincter functions besides anorectal malformation (spina bifida, ) * patients whose brain functions do not allow to reply to a questionnaire (mental retardation)

Keywords: anorectal malformation fecal incontinence quality of life child
meru health ascend mobile intervention for depression in middle aged and older adults

Conditions: Depression; Depressive Symptoms

Summary: using technology to deliver depression interventions is one way could alleviate the public health burden of depression. the study is testing a mobile app intervention program for depression that uses cognitive behavioral skills and mindfulness. this study seeks to obtain feedback on the intervention and refine the intervention and then test the intervention in a larger study. the mobile app intervention called the meru health ascend program consists of the app and therapist support via messaging within the app.

the meru health ascend program is a guided self-management program that uses a mobile application to deliver content of the intervention. a licensed therapist (meru health employed) provides support to participants as needed and reviews practice logs within the app.the 8-week program teaches cognitive behavioral techniques and mindfulness skills with the aim of improving the user's mental health. the platform provides informational videos, skills practices, group discussion, and messaging with the therapist. the meru health program enrolls participants in treatment groups that work through the program at the same time and can provide support to on another on the discussion board within the app. we are conducting two studies in middle aged and older adults with elevated depressive symptoms to evaluate the meru health ascend program. in the first study (study 1), we will examine the feasibility of the intervention in individuals aged 40 years or older with elevated depression symptoms using an iterative case series. specifically, we will examine the usability of app and materials, dropout and reasons for dropout, and user perceptions of the program. we will then conduct a proof-of-concept study (study 2) using a nonrandomized pre-post design to examine whether individuals achieve clinically significant reductions in depressive symptoms.

Eligibility criteria:
inclusion criteria: * owns a smart phone, resides in california, phq-9 score greater than or equal to 10, stable dose of medication (if taking psychotropic), able to read and understand english. exclusion criteria: * psychotic disorder, possible cognitive impairment, evidence of problematic drinking behavior, active suicide ideation with a plan, active psychological treatment, bipolar disorder (study 2 only)

Keywords: mobile app middle age adults older adults
antimicrobial resistance during the sars-cov-2 (covid-19) pandemic

Conditions: COVID-19

Summary: assess the incidence and rates of resistant pathogens prior to and during the covid-19 pandemic.

the covid-19 pandemic accelerated/exacerbated resistance rates for key pathogens. specifically, incidence of extended-spectrum beta-lactamase producing enterobacteriaceae (esblpe), carbapenem-resistant bacteria (crb), methicillin-resistant staphyloccoccus aureus (mrsa), vancomycin-resistant enterococci (vre), and c. difficile infections (cdi) will be higher in the pandemic time period (pandemic, march 2020 - february 2025) compared to the pre-pandemic period (pre-pandemic, march 2018 - february 2020).

Eligibility criteria:
inclusion criteria: * • patients admitted to methodist richardson, methodist mansfield, methodist charlton, or methodist dallas medical centers between march 2018 and august 2021. * \>18 years old exclusion criteria: * • outpatient visit * not admitted to an inpatient or observation status
high protein breakfast on appetite, postprandial glycemia and weight loss in t2d

Conditions: Type 2 Diabetes

Summary: the investigators hypothesis is that eating whey protein in the breakfast versus other proteins will results in higher satiety, reduced overall postprandial glycemia and more weight loss in obese diabetic individuals

recently we have shown that compared to low carbohydrate diet, an isocaloric diet with addition of high calorie and protein breakfast promoted sustained weight loss and prevented weight regain by reducing diet-induced compensatory changes in hunger, cravings and ghrelin suppression. however the effect of isocaloric and isoproteic breakfast with different source of proteins, (whey vs other proteins or vs low protein in breakfast) on weight loss, appetite and on glycemic fluctuations after breakfast lunch and dinner was not explored in obese diabetic individuals. to search whether compared to proteins like tuna, eggs and soy, the intake of whey protein in the breakfast will lead to reduced hunger and overall postprandial glycemia and will enhance weight loss in obese diabetic individuals

Eligibility criteria:
inclusion criteria: 1. subjects ≥30 and ≤70 years of age 2. bmi: 26 to 34 kg/m2) 3. diabetes criteria 4. hba1c: 7-9 % or 5. habitually eat breakfast 6. only naïve or treated with metformin. 7. those with anti-hypertensive and lipid-lowering medication will be included. 8. . not dieting and no change in body weight \>10 lb = 4.5 kg within the last 6 months 10.those who provide signed informed consent 11.stable physical activity pattern during the three months immediately preceding study initiation. 12. normal liver, kidney and thyroid function. 13. negative urinary microalbumin test (urma) and estimated glomerular filtration rate (gfr) \> 60 ml/min/1.73 m2. exclusion criteria: 1. type 1 diabetes 2. clinically significant pulmonary, cardiac, renal, hepatic, neurologic, psychiatric, infectious, malignant disease 3. anemia (hg \> 10 g/dl) 4. serum creatinine level \< 1.5 mg/dl 5. pulmonary disease, psychiatric, immunological, neoplastic diseases or severe diabetic complications, such as cardiovascular disease, cerebrovascular disease, proliferative diabetic retinopathy, gastroparesis or underwent bariatric surgery. 6. abnormal liver function tests defined as an increase by a factor of at least 2 above the upper normal limit of alanine aminotransferase and/or aspartate 7. infectious disease 8. malignancy 9. pregnant women or lactating 10. known hypersensitivity to milk components 10. participating in dietary program or using of weight-loss medications 11. documented or suspected history (within one year) of illicit drug abuse or alcoholism. 12. use of psychotropic, anorectic or steroid medication during the month immediately prior to study onset -

Keywords: whey protein hunger
assessment of pulmonary involvement inulcerative colitis by induced sputum

Conditions: Ulcerative Colitis

Summary: ulcerative colitis is a systemic disease we assume that extra intestinal involvement as we describein our study( fireman z, osipov a, kivity s, kopelman y, sternberg a fireman e: assessment of pulmonary involvement in crohn's disease by induced sputum. am j gastroenterol 2000;95(30):730-734. )

twenty ulcerative colitis patients and 20 control subjects (all nonsmokers) without respiratory symptoms will be tested. the induce sputum by 20' inhalation of 3.5% saline using ultrasonic nebulizer. samples will studied by differential counts of 200 cells on cytopreps stained by giemsa. t-lymphocyte subset analyses were done by facs using three monoclonal antibodies: cd3 = total t cells, cd4 = t helper cells, and cd8 = t suppressor-cytotoxic cells. cd4/cd8 \>2.5 was considered abnormal.

Eligibility criteria:
inclusion criteria: * all the ulceratvive colitis patients without lung involvmentage 18-75 years of age exclusion criteria: * pregnant women * non cooperative patients * smoker * lung disease

Keywords: ulcerative colits lung induced sputum our aim to evaluate lung involvement in ulcerative colitis patients by induced sputum
observational study, use of canakinumab administered subcutaneously in the treatment covid-19 pneumonia

Conditions: COVID-19

Summary: the study is configured as a retrospective and prospective observational study. the study will be multi-center and will involve all covid-19 pneumonia patients treated with canakinumab administered subcutaneously.


Eligibility criteria:
inclusion criteria: * patients with covid 19 who have received or are candidates to receive treatment with canakinumab subcutaneously * age\> 18 years * pneumonia diagnosed with chest x-ray / or chest ct exclusion criteria: * patients with covid19-related pathology in the context of another cause of major admission (trauma, surgery)
a phase 1/2 study of medi4276 in adults subjects with select her2-expressing advanced solid tumors.

Conditions: HER2 Expressing Breast or Gastric/Stomach Cancers

Summary: this research study is designed to evaluate an experimental drug, medi4276, in treating breast and stomach (gastric) cancer.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years. 2. histologically or cytologically documented unresectable, locally advanced or metastatic breast cancer or gastric cancer refractory to standard therapy. 1. for subjects with breast cancer: * prior treatment with trastuzumab, pertuzumab, and t-dm1, either alone or in combination, is required. * subjects with a primary tumor that is hormone (estrogen, progesterone, or both) receptor-positive or receptor-negative are eligible. * prior hormone therapy is allowed, but last dose must be at least 14 days prior to first dose of medi4276. 2. for subjects with gastric cancer: * prior treatment with a trastuzumab containing chemotherapy regimen is required. 3. her2 positive disease documented as fish-positive and/or 3+ by ihc on previously collected tumor tissue. 4. at least one lesion measurable by recist version 1.1. exclusion criteria: 1. receipt of any conventional or investigational anticancer treatment within 28 days prior to the first dose of medi4276. 2. history of exposure to the following cumulative doses of anthracyclines: 1. doxorubicin or liposomal doxorubicin \>350 mg/m². 2. epirubicin \>530 mg/m². 3. mitoxantrone \>90 mg/m² and idarubicin \> 70 mg/m². 4. if another anthracycline or more than 1 anthracycline has been used, then the cumulative dose must not exceed the equivalent of 350 mg/m² of doxorubicin. 3. known brain metastases that are untreated, symptomatic, or require therapy to control symptoms; or any radiation, surgery or other therapy to control symptoms from brain metastases within 2 months prior to first dose of medi4276.
neutrolin versus heparin for locking hemodialysis catheters

Conditions: Hemodialysis Catheter Infection; Catheter Thrombosis

Summary: hemodialysis catheter related bacterial infections represent a major cause of mortality and morbidity in the hemodialysis population. several locking agents had been tried with variable degree of success but not without side effects. neutrolin catheter locking agent comprises of heparin,citrate and trauolidine that had been studied in a prospective study in germany, and it demonstrated a very good result in terms of reducing the catheter related infections and thrombosis. this study is a multi-center, double-blind rct comparing the hemodialysis catheter locking solution neutrolin with heparin in reducing the rate of catheter related bacterial infection and thrombosis.


Eligibility criteria:
inclusion criteria: * new hemodialysis catheter * subject who will need chronic hemodialysis at least twice/week * subject likely to require for at least 120 days * subject or relative is likely to understand the nature of the study and sign the consent * age 18 years and older exclusion criteria: * subject with unstable malignancy * subject with liver cirrhosis with encephalopathy * subject know to have allergy to heparin, citrate or traoulidine * documented history of arterial thrombosis or known to have hypercoagulable state * subjects with active skin infections and ulcers
electrophysiology in congenital cataract after lensectomy and anterior

Conditions: Congenital Cataract

Summary: in this prospective study , a cohort of 91 eyes with congenital cataract and 25 eyes normal eyes from wenzhou medical university was erolled.91 eyes with congenital cataract was after lensectomy and anterior vitrectomy as test group, 25 normal eyes as control group. the a- and b-wave and phnr related parameters was evaluated.

secondary iol implantation in aphika children and lensectomy and anterior vitrectomy and primary iol implantation in children with congenital cataract were both performed by the same surgeon(z.y.e). electroretinography and photopic negative response are performed to each patient.the research was to evaluate the relationship between the best corrected visionn and the related parameters of a- and b-wave and phnr .

Eligibility criteria:
inclusion criteria: * phakic children diagnosed with congenital cataract who underwent secondary iol implantation and children with congenital cataract who underwent lensectomy and anterior vitrectomy and primary iol implantation exclusion criteria: * patients with mild cataracts do not require surgery

Keywords: erg