Kornimate/medical-research-clean huggingface dataset:
post-revascularization optimization and physiological evaluation of intermediate lesions

Conditions: Ischemic Heart Disease; Angina, Stable; Non ST Elevation Myocardial Infarction; ST Elevation Myocardial Infarction; Unstable Angina; Coronary Disease

Summary: prophet-ffr is a single center ambispective registry aiming to explore the impact of post-revascularization functional assessment on later outcomes.

prophet-ffr is a ambispective observational study enrolling patients that need invasive functional evaluation in the diagnostic workup of coronary artery disease. clinical outcomes of patients that undergo functional assessment after pci will be compared both to patients undergoing pci without further evaluations and both to patients that will be deferred due to to negative functional evaluation. since the observational nature of the study the decision to perform post-pci physiological assessment will be left to operator's discretion. in case of post-pci functional evaluation results that will be deemed as unsatisfactory by the operator further actions can be taken in order to optimize procedural result. the decision on this opportunity as well as the choice of the strategy to adopt are left to operator's discretion. the primary endpoint of the study is the rate of mace defined as the composite of spontaneous mi, target vessel failure, cardiac deaths at 24 months. follow up will be performed by telephone contact and medical records screening at 12, 24 and 36 months. moreover data about in-hospital events will be collected including the release of myocardial damage markers, change in creatinine, and lenght of hospital stay.

Eligibility criteria:
inclusion criteria: * requiring coronary angiography to assess coronary artery disease; * having at least one angiographically intermediate coronary stenosis (eg. 40%-80%) on any vessel requiring invasive functional assessment using ffr (and/or any other surrogate index) * being able and legally entitled to give informed consent exclusion criteria: * history of severe poorly uncontrolled pulmonary disease * hemodynamic instability during the diagnostic or therapeutic procedures; * known adenosine intolerance * need of mechanical circulatory or ventilatory support; * stage iv chronic kidney disease. * life expectancy \<1 year * patients gaining indication to surgical revascularization; * major procedural complications during percutaneous revascularization (cardiac arrest needing cardiopulmonary resuscitation, major bleeding , large iatrogenic coronary dissection, coronary embolization in a main vessel, suspected stroke) making post-pci functional evaluation unsafe or impossible.
evaluation of effectiveness of acupuncture on quality of life in patients with breast cancer receiving chemotherapy

Conditions: Breast Cancer

Summary: the aim of this trial is to investigate the effectiveness of acupuncture on quality of life in patients with breast cancer receiving chemotherapy compared to routine care.

at the mammazentrum hamburg, germany, patients with breast cancer receiving chemotherapy have the opportunity to get acupuncture in addition to conventional therapy to maintain quality of life and to reduce the side effects of the chemotherapy such as gastrointestinal disorders. in this randomized trial we aim to investigate the effectiveness of additional acupuncture compared to routine care in patients with breast cancer.

Eligibility criteria:
inclusion criteria: * diagnosed breast cancer (invasive, intraductal, hormone-sensitive and not hormone-sensitive, only locoregional metastases) * current chemotherapy at mammazentrum hamburg with regimen fec/doc or ec/doc * willingness to receive acupuncture within the next 6 month if randomized in acupuncture group * willingness to refrain from acupuncture within the next 6 month if randomized in control group * informed consent exclusion criteria: * distant metastases * blood coagulation disorder and/or current use of anticoagulants * serious acute or chronic mental or physical disorders * clinically relevant cardiac arrhythmia symptoms * insufficient german language ability

Keywords: breast cancer acupuncture quality of life
clinical findings and albuminuria as predictors of acute kidney injury in patients with acute heart failure

Conditions: Heart Failure; Acute Kidney Injury; Albuminuria

Summary: assess the predictive value of clinical examination and proteinuria as early measures for acute kidney injury (aki) in patient with acute heart failure and assessing their prognostic value as measures for mortality during hospital stay

heart failure (hf) is a chronic and progressive clinical syndrome induced by structural or functional cardiac abnormalities displaying either reduced (in hf with reduced ejection fraction (hfref)) or preserved (in hf with preserved ejection fraction (hfpef)) left ventricular ejection fraction (lvef) (1). current guidelines define the acute decompensated heart failure (adhf) syndrome as the presence of new or worsening signs and symptoms of hf that often lead to hospitalization or an emergency department visit for intensification of therapies (2-4). due to population growth and ageing, the total number of hf patients continues to rise. it is estimated that 64.3 million people live with hf worldwide. in developed countries, the prevalence of known hf is generally estimated at 1-2% of the general adult population.(3, 5) acute kidney injury (aki) is a frequently occurring complication of critical illness, with severe impact on morbidity and mortality. many studies focus on advanced measures, such as biomarkers or imaging for predicting aki. these techniques are frequently time-consuming, costly, and are not available on a global scale. in contrast, variables obtained by clinical examination are readily available without limitations by set- tings or costs. clinical examination signs and symptoms may reflect the underlying disease state and could therefore potentially be used to identify patients at risk for aki . in addition, a few studies have specifically focused on the role of albuminuria in predicting adverse outcomes in heart failure patients.

Eligibility criteria:
inclusion criteria: * all patients of 18 years and older who will be admitted to the icu with acute heart failure (acute heart failure is defined according esc guidelines 2021 which include heart failure with reduced ejection fraction (hfref) ef \&amp;lt;40% . mid-range ejection fraction (hfmref)(41 -46 %) , preserved ejection fraction (hfpef) ef ≥ 50%. exclusion criteria: * patients under the age of 18. patients with known chronic kidney disease (ckd) before icu admission (ckd is defined as the presence of kidney damage or an estimated glomerular filtration rate (egfr) less than 60 ml/min/1.73 mt2, persisting for 3 months or more, and or albuminuria more than 3.5 mg/mmol (12) severe uti

Keywords: heart failure acute kidney injury albuminuria
high intensity interval training versus intermittent fasting on functional capacity among overweight subjects

Conditions: Overweight

Summary: the purpose of the study is to compare the effect of high-intensity interval training and intermittent fasting on improving body weight and functional capacity among overweight subjects.

exercise improves cardiorespiratory fitness, muscle strength, endurance, body composition, and decreases visceral fat. the, increase in physical activity and modification of eating behaviors are the first line of interventions given because of their low costs and low risks of complications. most commonly, the continuous exercise of moderate intensity, that has to be performed several days of the week to get target benefits have been used, on the other hand, different forms of training which aim to reduce time spent exercising by increasing exercise intensity have been considered as an alternative to increasing adherence to the training program which is supported by some researches that may have greater benefits as high intensity interval training improves the vascular function of the muscle capillary density and endothelial nitric oxide synthase(enos) levels. but there are some overweight people even some of the young people have restriction to perform exercise programs due to any medical problem that could interfere with exercise. so, searching for optimal dietary interventions for obesity is still ongoing, but the modification in eating behaviors are hampered by difficulties in coping with a different diet. so, the diet with a fasting component that will be used in this study may be more effective than other complex and restrictive diets as it essentially limits the caloric intake to a specified period without major diet composition changes. so, the aim of this study is to compare the effect of high-intensity interval training and intermittent fasting on improving body weight and functional capacity among overweight subjects.

Eligibility criteria:
inclusion criteria: * subjects have to meet all the following criteria in order to participate in the study: 1. overweight subjects with age from 25 to 35 years. 2. body mass index will be range from 25 to 29.9 kg/m2. 3. waist circumference ≥ 80 cm2. 4. a minimum of 70% of exercise program and diet regimen compliance will be required in order to be included. exclusion criteria: * subjects with the following disorders will be excluded from participating in this study: 1. musculoskeletal, cardiovascular disorders. 2. asthma, chronic obstructive pulmonary diseases. 3. any systemic disease or condition that might reduce adherence or tolerance to exercise or fasting. 4. history of stroke.
comparing complete remission after treatment with selumetinib/placebo in patient with differentiated thyroid cancer

Conditions: Differentiated Thyroid Cancer

Summary: the study is designed to evaluate the clinical efficacy, safety and tolerability of selumetinib with radioactive iodine therapy in patients with differentiated thyroid cancer.

a randomised, double blind study to compare the complete remission rate following a 5-week course of selumetinib or placebo and single dose adjuvant radioactive iodine therapy in patients with differentiated thyroid cancer.

Eligibility criteria:
inclusion criteria: differentiated thyroid cancer tumor \>4 cm, or gross extra-thyroid extension, or 1 lymph node \>1 cm, or 5 or more lymph nodes of any size previous thyroidectomy must be able to receive radioactive iodine therapy must be able to receive thyroid stimulating hormone suppression exclusion criteria: metastaic disease anaplastic thyroid cancer, medullary thyroid cancer or hurthle cell carcinoma presence of anti-tg antibodies previous treatment with any radiation unresolved toxicity ≥ common terminology criteria for adverse event grade 2

Keywords: selumetinib, differentiated thyroid cancer , azd6244
preoxygenation with nasal cannula and noninvasive positive pressure ventilation

Conditions: Hypoxia

Summary: this is a prospective randomized cross over study of healthy volunteers comparing end-tidal oxygen concentration among subjects undergoing continuous positive airway pressure ventilation via a noninvasive ventilation (niv) mask with and without the addition of nasal cannulas.

noninvasive positive pressure ventilation with the addition of a nasal cannula is a useful technique to pre-oxygenate and provide apneic oxygenation in hypoxic patients undergoing emergency airway management. this study aims to evaluate preoxygenation by quantifying end-tidal oxygen (eto2) concentration resulting from nasal cannula placement underneath a noninvasive positive pressure ventilation (nippv) mask. this is a prospective randomized cross over study of healthy volunteers undergoing continuous positive airway pressure ventilation via a noninvasive ventilation (niv) mask with and without the addition of nasal cannulas. end-tidal oxygen concentration will be measured by an oxygen sensor following three minutes of nippv with and without the addition of a nasal cannula, with each subject serving as his or her own control.

Eligibility criteria:
inclusion criteria: * any healthy volunteer aged 18-65 years. exclusion criteria: * previous inability to tolerate noninvasive positive pressure ventilation with addition of a nasal cannula. * known underlying cardiac or pulmonary disease. * active respiratory infections.
a randomized controlled trial of acupuncture in treating migraine

Conditions: Migraine Without Aura

Summary: migraine without aura is a common kind of nervous system diseases that can easily cause recurrent headache, leading to severe impacts on quality of life and health care costs. current therapeutic options for migraine without aura mainly include flunarizine hydrochloride that can relieve vasospasm. nevertheless, the efficacy of flunarizine hydrochloride is always limited by inevitable side effects, which result in poor compliance of patients. moreover, for some most suffering patients, the control of pain is often unsatisfactory despite of the administration of complex treatment combinations. as a non-pharmaceutical therapy, acupuncture is widely used for a wide range of pain conditions. thus, it might be an alternative treatment for migraine without aura. the aim of this randomized controlled trial is to investigate the efficacy and safety of acupuncture therapy in patients with migraine without aura from the perspective of regulating ying and wei.

this randomized controlled trial will enroll 96 migraine patients without aura from the third affiliated hospital of zhejiang chinese medical university. all patients will be randomly assigned to either the acupuncture combined with placebo group or sham acupuncture combined with medication group through a randomization system. primary outcome will be pain intensity assessed by visual analogue scale (vas) scale. secondary outcomes will include migraine-specific quality of life (msqol) scale and headache needs assessment survey (hana) questionnaire scale.

Eligibility criteria:
inclusion criteria: 1. patients meet the diagnostic criteria of migraine without aura; 2. 25 ≤ age ≤50 years, male or female; 3. the efficacy of drugs and other therapeutic methods is not obvious; the frequency of migraine attacks in the past 3 months is more than twice a month; 4. drug treatment for migraine without aura is stopped for at least one week; 5. participants can understand the study protocol and written informed consent is signed. exclusion criteria: 1. patients have severe complications in cardiovascular, liver, kidney, hematopoietic and other systems; 2. pregnant or lactating women; 3. patients have spontaneous bleeding tendency so it is not suitable for them to receive acupuncture; 4. patients have an allergic history of flunarizine hydrochloride or a history of depression; 5. patients are diagnosed as psychosis.

Keywords: migraine, acupuncture, randomized controlled trial
methodological evaluation of gingival crevicular fluid volume and elastase level

Conditions: Chronic Periodontitis

Summary: the mechanisms underlying the formation and composition of gingival crevicular fluid (gcf) and its flow into and from periodontal pockets are not understood very well. the aim of this study was to evaluate the length of sampling time and sequential sampling of gcf neutrophil elastase (ne) enzyme activity by using intracrevicular and orifice methods.

twenty adults (mean age of 41.8 years. ranged 31-60 years. 18 males. 2 females) with chronic periodontitis were enrolled and all completed the 3-day study. three-hundred-sixty samples of gcf were harvested from the interproximal sites of each of the two maxillary non-molar teeth according to the orifice method. each site was sampled three times with 1-min intervals between repeat samples. by using intracrevicular method, the other 360 samples of gcf were collected on the same sites following 10-minutes interval. in first day, 2nd day and 3rd day the length of sampling time in seconds and order were 5. 10. 30; 10. 30. 5 and 30. 5. 10. respectively. gcf elastase activity was determined by hydrolysis of neutrophil specific substrate n-methoxysuccinyl-ala-ala-pro-val-p-nitroanilide and was expressed as concentration (microu/microl) and total enzyme activity (microu).

Eligibility criteria:
inclusion criteria: * no history of systemic disease; * no history of antibiotics and/or anti-inflammatory drugs within the past 6 months; * no received any oral hygiene prophylaxis and scaling and root planing within the past 6 months; * at least 2 interproximal sites exhibiting higher than 5 mm probing depth, radiographic bone loss and gingival index of 2 (with preference of two maxillary non-molar teeth) exclusion criteria: * with metabolic diseases * pregnancy, lactation etc.
effect of breather on hospital stay in patients with acquired pneumonia

Conditions: Pneumonia Hospital Acquired

Summary: acquired pneumonia is a sever medical condition that addressed as life-threatening issue require intensive care. medical breather device permits activating and strengthening of both inspiratory and expiratory musculatures; thus, it could be useful for pneumatic patients. the aim of the study is to investigate breather effect on hospital stay in pneumatic patients.

sixty participants diagnosed with acquired pneumonia '30 women, 30 men; selected from chest department of kasr alaini intensive care unit (icu) at cairo university. they were randomly allocated into equal groups; group a received respiratory training via incentive spirometer, and traditional chest physiotherapy; and group b received respiratory training via breather, and traditional chest physiotherapy. both received 3 session daily/2 weeks. diaphragmatic excursion, respiratory distress observation scale, and icu discharge were assessed pre and post treatment. careful recruitment of participants based on the study criteria by both icu resident and pt consultant. identified inclusive criteria include conscious both genders aged 30- 40 years old with bmi ranged from 25 to5 29.9 kg/m2 had an acquired pneumonia with a mild hypoxemia (o2 saturation was 90 - 95%). aware participants whom cooperated through accurate understand and perform instructions. excluding patients through identified inclusive criteria that if they had a history of any malignant tumors, hearing impairment or mental disorder, auto-immune diseases, a history of any surgical transplantation, unstable hemodynamics, rib fracture, a history of neuromuscular disease, spinal injuries, or bmi \> 30 kg/m2. also, patients receiving mechanical ventilation, or whom require mv, but contraindicated for rehabilitation i.e., pulmonary emboli were excluded.

Eligibility criteria:
inclusion criteria: 1. sixty patients of both sexes from intensive care unit, cairo university hospitals. 2. their age ranged from 30 to 40 years old. 3. their bmi were from 25 - 29.9 kg/m2. 4. their oxygen saturation 90 - 95% (mild hypoxemia) conscious level. exclusion criteria: 1. patient with a history of any malignant tumors. 2. patients with hearing impairment or mental disorder. 3. patients with auto-immune diseases. 4. patients with a history of any surgical transplantation. 5. patients with hemo-dynamically unstable patients. 6. patients with rib fracture. 7. patients with history of neuromuscular disease. 8. patients with spinal injuries. 9. patients with bmi \> 30 kg/m2. 10. patients receiving mechanical ventilation. -

Keywords: incentive spirometry,breather, acquired pneumonia, arterial blood gases
tenofovir disoproxil fumarate in the treatment of parkinson's disease

Conditions: Parkinson Disease

Summary: to evaluate the efficacy and safety of tenofovir disoproxil fumarate in the treatment of parkinson's disease. the changes of motor symptoms and the occurrence of adverse reactions in early parkinson's disease patients who took tenofovir disoproxil fumarate and did not take tenofovir disoproxil fumarate at different time points were compared.


Eligibility criteria:
inclusion criteria: * 1: parkinson's disease: hoehn yahr= 1 to 2.5 2: mmse score≥24 exclusion criteria: * 1: essential tremor, stroke, epilepsy and other well-defined neurological disorders 2: or have received deep brain stimulation and other brain surgery 3: abnormal liver and kidney function 4: infected with chronic hepatitis b or aids (hiv-1 infection) 5: severe depression, schizophrenia, other psychiatric disorders or drug dependence 6: other serious physical diseases such as heart, lung, liver, kidney disease, blood disease and malignant tumor 7: pregnant or lactating women and seniors over 65 years of age 8: allergy or other contraindications to the investigational drug
difference in h. pylori infection rate of egc patients before and after endoscopic resection

Conditions: Early Gastric Cancer

Summary: parts of patients are diagnosed as h. pylori -negative before er, whereas the specimens become h. pylori-positive after er, which may have a role in the recurrence of egc. our study aims to determine the difference in h. pylori infection rate of egc patients before and after er , and discuss the causes leading to the difference, which can provide references for improving the diagnostic accuracy of h. pylori infection and reducing egc's recurrence rate.

gastric cancer is the fourth most commonly diagnosed cancer in the world and the second leading cause of cancer-related deaths. nowadays, endoscopic resection（er） is widely accepted as the primary treatment for early gastric cancer (egc) without lymph node metastasis，which includes endoscopic mucosal resection (emr) and endoscopic submucosal dissection (esd).however, recurrence rate after endoscopic resection for egc still achieves 6.7%-14%. however, there is no comparative analysis about h. pylori infection rate before and after er yet.

Eligibility criteria:
inclusion criteria: * high grade dysplasia(hgd) and egc patients treated by endoscopic resection(including emr and esd) in ren ji hospital exclusion criteria: * suspect of advanced gastric cancer * lesions with light grade dysplasia * history of gastric surgery * poor gastrointestinal preparation * patients under unsuitable conditions for examination or treatment, such as acute upper gastrointestinal bleeding, noncorrectable coagulopathy, severe systemic disease, etc

Keywords: endoscopic resection h. pylori infection
impact of branched-chain amino acids in the development of insulin resistance

Conditions: Diabetes

Summary: the purpose of this study is to clarify the role of the branched-chain amino acids in the development of insulin resistance in patients with diabetes

the proposed project aims to elucidate the role of the bcaa in the development of insulin resistance and type 2 diabetes. the project tests the hypothesis that a diet induced decrease of bcaas concentrations alter the metabolic mechanisms involved in the control insulin resistance and diabetes progression. the specific aims are to elucidate the effect of the diet induced decrease of bcaas concentrations on (i) peripheral and hepatic insulin sensitivity (ii) ectopic fat distribution (iii) energy metabolism (iv) metabolic and inflammatory status

Eligibility criteria:
inclusion criteria: * diabetes type 2 * non smokers * untrained * willingness to adhere to a diet intervention exclusion criteria: * chronic disease * pregnancy * cancer * antibiotic therapy * drug/alcohol abuse * competitive athletes