Kornimate/medical-research-clean huggingface dataset:
treatment of sinus headache using a novel device that combines acoustic vibration with oscillating expiratory pressure

Conditions: Facial Pain

Summary: the purpose of this study is to investigate if the sinusonic device decreases facial pain and pressure compared to the placebo device.


Eligibility criteria:
inclusion criteria: * participant must be \> 18 years of age inclusive, at the time of signing the informed consent. * participants who are overtly healthy as determined by medical evaluation including medical history and physical examination. * capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (icf) and in this protocol. * facial pain or pressure for \> 3 months of symptom duration. * pain/pressure vas (visual analogue scale) score of \> 5. exclusion criteria: * upper respiratory illness within the last 2 weeks. * history of severe epistaxis. * known pregnancy. * allergic sensitivity to silicone or any other component of device. * sinonasal surgery in the last 3 months. * topical decongestant use in the last week. * nasal polyposis, purulence/edema, or other signs of sinusitis on exam. * sinusitis on imaging. * nasal crusting or ulceration on exam. * inability to read or understand english.

Keywords: facial pressure
comparison between two sub-types of high intensity interval training

Conditions: Diabetes Mellitus

Summary: recently, hiit has been recommended by the american diabetes association for type 2 diabetes. the high-volume hiit has been studied extensively in patients with type 2 diabetes, however, little is known about the effectiveness of low-volume hiit regarding target glycemic or lipid control in these patients. therefore, the purpose of this study is to compare between two subtypes of hiit (i.e. the low-volume hiit versus the high-volume hiit) with respect to exercise-induced changes in blood glucose, lipid profile and anthropometry in patients with type 2 diabetes mellitus. statement of the problem is there any difference between the effect of high-volume and the low-volume high intensity interval training on glycemic and lipids control in type 2 diabetes? purpose of the study: to assess the effect of the high-volume versus the low-volume high intensity interval training on glycemic and blood lipids control in type 2 diabetes. null hypothesis: there will be no difference between the effect of the high-volume versus the low-volume high intensity interval training on glycemic and blood lipids control in type 2 diabetes.


Eligibility criteria:
inclusion criteria: 1. type ii diabetes mellitus diagnosed by a physician as having hba 1c of \&gt; 6.5%. 2. an established diagnosis of t2dm for at least 1year and less than 5 years. 3. women patients. 4. age between 35 to 45 years old. 5. systolic blood pressure less than or equal 130 mmhg. 6. obese patients (bmi is between 30 and 39.9 kg/m 2 ) 7. patients with hba 1c of 7-9%. 8. a self-reported sedentary lifestyle. 9. patients receiving oral hypoglycemic medications described by the physician 10. patients with hyperlipidemia. exclusion criteria: 1. patients with cardiac diseases. 2. patients with glaucoma. 3. patients with diabetic complications (diabetic foot, retinopathy, nephropathy, and diabetic peripheral neuropathy). 4. musculoskeletal or neurological limitations to physical exercise. 5. pregnancy 6. patients under insulin therapy 7. patients with poorly controlled dm (hba1c \&gt; 9%) 8. bronchial asthma and chronic obstructive pulmonary disease. 9. smokers. 10. morbidly obese bmi ≥ 40 kg/m 2 11. males. 11. systolic blood pressure more than 130 mmhg. 12. anemia ( hemoglobin \&lt; 12 g/dl) 13. osteopenia.

Keywords: dm
a study of ym155 plus docetaxel as first-line treatment in subjects with her2 negative metastatic breast cancer

Conditions: Breast Cancer

Summary: the purpose of this study is to evaluate survival, response rate, safety and tolerability of ym155 given in combination with docetaxel as first-line treatment in subjects with human epidermal growth factor 2 non-overexpressing (her2 negative) metastatic breast cancer.

this is an outpatient study. all subjects enrolled in this study will receive a combined regimen of ym155 and docetaxel or docetaxel alone given during 21 day cycles. each subject will be assessed at the end of each cycle to determine if the subject can continue to the next cycle. each subject assigned to receive ym155 in combination with docetaxel will be eligible to continue receiving the combination regimen in this study until one of the discontinuation criteria is met. if a subject discontinues treatment with at least stable disease (sd) that subject will complete follow-up visits every 12 weeks for 2 years or until initiating another systemic anti-breast cancer treatment, exhibiting progressive disease (pd), or death. each subject will be contacted by the study site every 12 weeks for survival following the end of treatment visit. the contacts will continue until death or for no more than 2 years.

Eligibility criteria:
inclusion criteria: * histologically- or cytologically-proven adenocarcinoma of the breast that is her2 negative. subjects with hormone receptor positive or negative status are eligible. additionally, subjects with triple negative status (meaning estrogen receptor negative, progesterone receptor negative and her2 negative) are eligible * no prior chemotherapy regimen for metastatic breast cancer * eastern cooperative oncology group (ecog) performance status ≤ 1 at the baseline visit * the subject's life expectancy is estimated to be \> 12 weeks at the baseline visit * the subject must be non-pregnant and non-lactating. all sexually active subjects of childbearing potential must agree to use an adequate method of contraception throughout the study period exclusion criteria: * hypersensitivity to docetaxel or polysorbate 80 * neuropathy ≥ grade 2 at the baseline visit * known brain or leptomeningeal metastasis as assessed through medical history review and physical examination * the subject has known human immunodeficiency virus (hiv), hepatitis b surface antigen or hepatitis c antibody

Keywords: breast cancer metastatic her2 negative ym155
impulse control in gilles de la tourette syndrome

Conditions: Tourette Syndrome

Summary: the study intends to evaluate the role of mirror neurons in the determination of gestures, words, and repetitive vocalizations in subjects affected by tourette's syndrome and to verify if these subjects are faster to assemble sounds, in phonology and morphology, than the non-pathological population.


Eligibility criteria:
inclusion criteria: tourette group * consecutive patients belonging to the tourette center * caucasian * italian mother-tongue * age between 6 and 10 years completed * male and female 4: 1 (16 males and 4 females) * diagnosis of tourette's syndrome for at least 1 year * presence of a value of ygtss\> 50% not group tourette * caucasian * italian mother-tongue * age between 6 and 10 years completed * male and female 4: 1 (16 males and 4 females) exclusion criteria: tourette group * diagnosis of dsa * presence of significant psychiatric disorders, with the exception of those belonging to the tourette syndrome itself (eg adhd, ocd). not group tourette * diagnosis of dsa * presence of significant psychiatric disorders
the parenting young children check-up: proof-of-concept trial

Conditions: Disruptive Behavior Disorders

Summary: the parenting young children check-up (pycc) is a 3-part system for parents of children with disruptive behavior problems (dbps). first, at a pediatric visit, parents complete a screener for dbps and, if reported, go through a tablet-based program to receive feedback and learn about the pycc. next, parents receive text messages to connect them to further parent training content. third, parent training content is delivered via a web-based resource, which includes videos to teach parenting skills. in this proof-of-concept trial, the investigators will examine the acceptability of the tablet-based program and motivation of parents to engage in the pycc and use the web-based resource. at a pediatric visit, parents will be told about the research opportunity by a staff member before, during, or after their visit. there will be a flier for parents, which will be available for receptionists to include with in-take paperwork. if parents express openness to participating, a research assistant will meet with them, go over the consent form, and let them complete the screener. parents will complete a demographics questionnaire and the dbp screener. if parents report elevated dbps, then they will be eligible to further participate. if they are eligible and choose to participate, the research assistant will have them go through the tablet-based program. next, they will complete a brief questionnaire asking for input on the pycc. each of these components will be completed in the computerized intervention authoring system (cias). the brief questionnaire is intended to evaluate perceptions of 1) ease of use, 2) usefulness of the information, 3) likability, and 4) intentions to use the pycc web-based resource. items will be rated on a 0 (strongly disagree) to 4 (strongly agree) scale. parents will also verbally answer 6 open-ended interview questions about the program and suggest improvements. answers will be audio-recorded and transcribed. all participants (whether only completing the screening or both parts of the study) will receive a resource list as well as a list of urls to access videos on the video-based content on pycc website. an id number will need to be entered to use the website and the investigators will track website use. this data collection is not hypothesis driven. rather, the intent is to gather mixed methods feedback from parents to shape the pycc program.


Eligibility criteria:
inclusion criteria: * age 18 or above * english speaking * parent to a child ages 2-5 * report their child has elevated disruptive behavior problems on the eyberg child behavior inventory exclusion criteria: * parent reports child has autism spectrum disorder * parent reports child has an intellectual disability * parent reports child is receiving treatment for oppositional defiant disorder or attention deficit hyperactivity disorder

Keywords: parenting interventions parent training technology-based intervention disruptive behavior problems early childhood
impact of the use of vert on body image after bariatric surgery

Conditions: Obesity; Bariatric Surgery Candidate

Summary: the purpose ot the study is to assess the effectiveness of the use of vert on improving body image at 12 months in patients who underwent bariatric surgery in the weight stabilization phase (between 18 and 30 months after bariatric) presenting dissatisfaction with their body image compared to standard follow-up in post-bariatric surgery (lack of specific management of body image).

virtual reality therapy makes it possible to work on the integration of proprioceptive information via the reproduction of environments close to reality and therefore allow the patient to accept his new identity. this tool is used in an increasing number of indications and in particular in the management of dysmorphophobia in patients suffering from anorexia nervosa. in the context of bariatric surgery, only case reports have been published so far. significant improvements in the body satisfaction scores of patients have been showed, in patients who had undergone bariatric surgery who presented bodily dissatisfaction after 6 weeks of virtual reality. however, larger numbers, longer follow-up periods and more rigorous methodologies are needed to confirm the impact of this practice. the hypothesis of the study is that virtual reality therapy could improve body image in patients who are dissatisfied with their body image after bariatric surgery.

Eligibility criteria:
* inclusion criteria: patients who underwent bariatric surgery in the weight stabilization phase (between 18 and 30 months after surgery) presenting dissatisfaction with their body image according to the bsq (score ≥ 111), to be affiliated to the french social security system. the prior, free and informed consent of the patient shall be obtained. * exclusion criteria: patients with disabling nausea (motion sickness) from previous use of a virtual reality headset, patients who had from post-bariatric reconstructive surgery, epileptic patients, decompensation of a psychiatric pathology

Keywords: virtual reality exposure therapy body image dysmorphophobia
the elg analysis of glucose a correlational to blood glucose assay

Conditions: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2

Summary: this study is an investigational study of the elg medical device to monitor glucose blood level in diabetes mellitus type 1 and 2 without blood samples in comparison to blood testing methods."investigational" means the elg medical device is subjected by the fda (food and drug administration) for premarket testing requirements. the purpose of this study is to collect data comparison values between elg testing device to current blood testing methods.


Eligibility criteria:
inclusion criteria: * have been diagnosed with type 1 or 2 diabetes * be 25 - 65 years of age * male or female * various ethnicities are desired * must be available for 2 visits within a 2-4 week period and willing to spend up to 1-2 hours/visit * must have daytime availability for visits * able to have 1 venous blood draw \& up to 4 fingersticks for complete blood testing at each visit * must be willing and able to fast (for at least 6 hours) prior to first visit exclusion criteria: * taking drugs of abuse (illegal and/or prescription) * have been in another research study in the last 30 days * have had a blood transfusion or severe blood loss in the last 14 days * have sickle cell anemia

Keywords: elg diabetes
effects of a surgical site injection on pain scores and narcotic use after orthopaedic trauma surgery

Conditions: Pertrochanteric Fracture

Summary: this is a phase i, randomized, single-blind, placebo-controlled, single-center study of the effects of surgical site injection on pain and narcotic utilization in participants who undergo surgery for lower extremity fractures. 200 participants with lower extremity fractures who are admitted for operative fixation will be included in the study. participants will be randomized to receive either a pain cocktail injection around the fracture site and surrounding tissues or control (no injection). an analysis of pain scores, rehabilitation progress, length of stay, narcotic utilization, and satisfaction scores will be performed.


Eligibility criteria:
inclusion criteria: * lower extremity fracture including femoral neck, intertrochanteric, sub-trochanteric, and femoral shaft fracture exclusion criteria: * pregnant women * treatment with arthroplasty * patients who receive a peripheral nerve block * patients who receive intra-op or post-op ketamine * patients with concomitant tbi or mr * polytrauma patients * pathologic fractures * patients who live greater than 10 miles from nyu or who will not be followed by an nyu provider * patients with a contraindication to any of the medications on the study list due to other medical problems such as renal or liver disease or due to allergy/intolerance * patients with prior extremity weakness resulting from stroke or other neurological condition * prior or current history of narcotic use * patients with advanced dementia * nyumc students, residents, faculty
a study of ly2605541 and glargine in participants with type 1 diabetes

Conditions: Diabetes Mellitus, Type 1

Summary: this study has 2 parts. each participant will receive a daily injection of ly2605541 during one treatment period and a daily injection of insulin glargine during one treatment period. each treatment period is 2 to 3 weeks and is followed by a procedure to lower blood sugar levels to see how the body recovers after each treatment.


Eligibility criteria:
inclusion criteria: * type 1 diabetic for more than 1 year with glycated hemoglobin (hba1c) less than 9% * otherwise fit and healthy * nonsmoker exclusion criteria: * taking medication or supplements other than insulin to control diabetes * suffered a hypoglycemic event in the last 12 months that required hospitalization or has poor awareness of hypoglycemia
young women on sexual and reproductive health knowledge and stigma levels

Conditions: Sexuality; Stigmatization; Inflammation

Summary: aim: failure to exercise reproductive and sexual rights can increase the risk of unwanted pregnancies, hiv and sexually transmitted infections, sexual coercion and violence, especially in young women. all of these situations affect the physical and mental health of young girls, as well as the health of their families.for this reason, the effect of education given to young women on sexual and reproductive health knowledge and stigma levels: a randomized controlled study was planned. material and method: the research was conducted as a randomized controlled experimental study. the universe of the research consisted of female students studying at the faculty of health sciences of ağrı i̇brahim çeçen university between january and june 2022. the sample consisted of individuals who were studying at the faculty of health sciences of ağrı i̇brahim çeçen university between the same dates and who met the inclusion criteria of the research. "descriptive feature form", "sexual and reproductive health stigma scale for young women" and sexual health knowledge test were used to collect data. in the analysis of data; percentile distribution, chi-square, fisher-freeman- halton exact test, paired samples test, t-test in independent groups, friedman test, one way anova test, and post hoc analyzes (bonferroni, games howell, dunn) were used.


Eligibility criteria:
inclusion criteria: be between the ages of 18-24. agree to participate voluntarily. - exclusion criteria: be over 24 years old -

Keywords: sexual health knowledge stigma
ccta-based coronary plaque characterization and high-sensitive troponin t for the prediction of cardiovascular outcomes

Conditions: Coronary Artery Disease; Noninvasive Plaque Characterization

Summary: to determine the ability of semi-automated plaque assessment in cardiac computed tomography angiography (ccta) and high sensitive troponin t (hstnt) for the risk stratification of patients at intermediate risk for coronary artery disease (cad).


Eligibility criteria:
inclusion criteria: * clinical indication for ccta according to the current appropriate use criteria exclusion criteria: * non-sinus rhythm * acute coronary syndromes * cardiomyopathies * moderate or severe valvular disease * elevated serum creatinine (\>1.5 mg/dl) * history or ecg signs of previous myocardial infarction * severe iodine allergy.
vestibular cochlear implant hearing impaired child

Conditions: Vestibular Abnormality

Summary: cochlear implantation (ci) is a well-known surgical procedure to rehabilitate patients with severe to profound sensorineural hearing loss. indications for this surgery have expanded in the last 10 years including bilateral ci. although ci has been described as a safe procedure with few major complications, it may have an adverse effect on the vestibular functions and produce dizziness. prevalence of postoperative dizziness varies widely in the literature and is said to affect between 2% - 47%.

the structural and functional integrity of the vestibular system is necessary for maintenance of the complex postural system and adaptation to the environment. the absence of vestibular function is accompanied by poor prognosis and severe limitations in the activities of daily life, such as ambulating in low-light environments or on uneven ground, swimming, driving fast, etc. the exact mechanisms responsible for the postoperative vestibular changes and/or symptoms, but several theories exist. because of the very anatomic proximity between the auditory and vestibular systems, and their embryologic and physiologic alterations, they may be simultaneously involved in some bodily dysfunctions. this involvement is more frequent in peripheral alterations than in central ones. the lateral wall and the fluid space are breached during cochleostomy. insertion of electrode array may cause changes in the normal fluid homeostasis of the inner ear, damage to the basilar membrane, osseous spiral lamina and vestibular receptors; utricle, saccule and semicircular canals, surgery-induced inflammation resulting in fibrosis or loss of hair cells, foreign body reaction (labyrinthitis), produce perilymph leakage and alter the pressure in the inner ear. in addition, the electric stimulation of the cochlear implant may cause pathologic changes in the inner ear as a subsequent dysfunction of structures, resulting in vestibular alterations. in previous research, the following vestibular assessments were utilized to determine vestibular injuries after ci: caloric response, videonystagmography (vng), vestibular-evoked myogenic potentials (vemps), video head impulse test (vhit), rotatory chair and scleral search coil. knowledge of vestibular system function before and after ci surgery is important for the satisfactory management of each case. it also helps in the selection of which ear to implant to avoid bilateral vestibular areflexia and can assist in the management of any postoperative vestibular symptoms. so, there are two questions that should be raised when we consider the vestibular function of a patient who will submitted to ci: is vestibular function present or not? and is the function symmetric?

Eligibility criteria:
inclusion criteria: 1. children with bilateral severe to profound sensorineural hearing loss. 2. age less than 6years at time of implantation. 3. prelingual deafness. exclusion criteria: * incomplete follow up. * other pathologies affecting balance as orthopedic problems before surgery.

Keywords: vestibular cochlear implant hearing child
dexamethasone vs. dexmedetomidine for espb in pain management after hip arthroplasty

Conditions: Hip Osteoarthritis; Hip Arthropathy; Hip Pain Chronic

Summary: effect of perineurial dexamethasone and dexmedetomidine on erector spinal plane block duration for hip arthroplasty

this study is proposed to explore the effect of perineurial dexamethasone and dexmedetomidine on erector spinal plane block duration for spine surgery. after spine surgery, patients need good analgesia. peripheral nerve blocks have provided a safe, effective method to control early postoperative pain when symptoms are most severe. the safety of local anaesthesia is essential due to the much lower toxicity threshold of local anaesthetics. an effective adjuvant, such as dexamethasone or dexmedetomidine, could allow for a higher dilution of local anaesthetics while maintaining and enhancing their analgesic effect. there is considerable research where intravenous and perineural dexamethasone and dexmedetomidine use have been compared in adults. however, there is a massive lack of research regarding spine surgery and the erector spinae plane block. in this study, investigators compare perineural dexamethasone and dexmedetomidine. the investigator aims to find a dexamethasone or dexmedetomidine that covers the need for good pain relief and fast recovery postoperatively.

Eligibility criteria:
inclusion criteria: * patients undergoing primary hip arthroplasty * aged \>18 years and \<100 years * asa physical status 1, 2 or 3. exclusion criteria: * if they refused to participate, * had a history of opioid abuse, * had an infection of the site of needle puncture, * were less than 18 years of age, * were postponed as having asa 4 or 5, * had an allergy to any of the drugs used in the study, * renal failure (estimated glomerular filtration rate \<15ml/min/1.73m2), * liver failure, * known or suspected coagulopathy, * pre-existing anatomical or neurological disorders in the lower extremities, * intellectual disability with problems in pain evaluation, * severe psychiatric illness.