Kornimate/medical-research-clean huggingface dataset:
comparison of pupillometry-guided anesthesia with surgical pleth index guided anesthesia

Conditions: Cholecystectomy, Laparoscopic; Anesthesia, General; Reflex, Pupillary

Summary: in this study, the investigators measure a pupil size every 5 minutes during the operation in patients undergoing laparoscopic cholecystectomy under general anesthesia. the investigators would compare the intraoperative opioid consumption and postoperative pain between the group adjusted the anesthetic drug concentration based on the changes of the pupil (pupil group) and the group based on the changes of a surgical pleth index (spi group).


Eligibility criteria:
inclusion criteria: * patients aged 20 to 65 yr, american society of anesthesiologist physical status(asa ps) i to ii, scheduled for a laparoscopic cholecystectomy under general anesthesia exclusion criteria: * presence of ophthalmologic diseases such as horner's syndrome or sjogren's disease. * presence of neurologic or metabolic diseases * medicated that could interfere with the autonomous nervous system (e.g., b- blockers, anticholinergics) * history of substance abuse or psychiatric disease * with chronic pain or preoperative analgesics * with pacemaker or arrhythmia
the effect of comedy film on preoperative anxiety and postoperative pain level.

Conditions: General Surgery; Anxiety; Pain

Summary: when we look at the literature, studies examining the effect of having patients watch comedy films on anxiety and pain are limited. however, it was observed that the anxiety and pain levels of oncology patients who underwent surgery decreased by watching comedy movies. therefore, in order to use the healing effects of humor, our study was planned to determine the effect of watching comedy films on the level of anxiety and postoperative pain in patients undergoing abdominal surgery.

whether it is major surgery or minor surgery, preoperative anxiety is observed in all patients in the preoperative period. a high level of anxiety causes many physiological and psychological problems in the body and causes an increase in sympathetic and endocrine system stimuli. among the physiological and psychological problems seen, many conditions such as recovery time, quality of life, health care expenditures, vital signs and well-being are negatively affected. therefore, many applications can be used to reduce the level of anxiety before surgery. with humor, which is one of them, the anxiety levels of the patients can be reduced and they can manage their stress management better. in addition to reducing the level of anxiety before the operation, the experience of post-operative pain is one of the important problems experienced by the patients. pain complaints are a general problem in the postoperative period in abdominal surgeries. the usefulness of using supportive complementary and alternative therapies in addition to pharmacological treatments in postoperative pain management is emphasized in the literature. among these non-pharmacological treatments, it is stated that humor and laughter increase tolerance to pain and have positive effects on mood. humor and laughter not only increase pain tolerance, but also reduce fear, anxiety and anger, and help lower the level of anxiety. therefore, in order to use the healing effects of humor, our study was planned to determine the effect of watching comedy films on the level of anxiety and postoperative pain in patients undergoing abdominal surgery.

Eligibility criteria:
inclusion criteria: * 18 years and over, * defining the postoperative pain intensity of 4 and above, * no cognitive problem * willing to participate in the research * having had abdominal surgery. exclusion criteria: * with a communication barrier, * having an uncontrollable psychiatric disorder,

Keywords: abdominal surgery preoperative anxiety comedy film postoperative pain
situation and evolution of the misuse of alcohol and other addictive behaviors in obese patients being managed at nîmes university hospital

Conditions: Obesity

Summary: obesity is a multifactorial pathology in which external (lifestyle, environment) and internal (psychological or biological, especially genetic) factors are involved. these are responsible for a positive energy balance. one of the external factors that can intervene in the genesis of obesity is the existence of eating disorders: bulimic hyperphagia. some teams consider bulimic hyperphagia as a form of addiction. after bariatric surgery, the appearance of new addictions has been observed. in connection with pr perney's addictology department, the investigators have observed that some patients under treatment for obesity at the endocrinology department subsequently developed other addictions, in particular misuse of alcohol. the hypotheses of this research are : there appears to be a transfer from eating disorders to substance misuse addiction in post-treatment of obesity, particularly in patients who have undergone bariatric surgery. the misuse of addictive substances most concerned by this transfer of addiction in the post-treatment of obesity, particularly after bariatric surgery, seems to be the misuse of alcohol. this will be the first french cohort study on addictive behaviors in patients undergoing bariatric surgery and the first international study including non-operated obese patients benefiting from medical care alone. this study will improve the multidisciplinary management of these patients by integrating addictologists.


Eligibility criteria:
* patient being managed for the first time at nîmes university hospital obesity clinic ( complete hospitalization, outpatients' or consultation). * patient being managed for obesity defined by a body mass index (bmi) of 30 kg.m-² or over * patient affiliated to or covered by a health insurance scheme. * adult patient (≥ 18 years). exclusion criteria: * patient with psychiatric disorder reducing capacity for comprehension. * patient in an exclusion period determined by another study. * patient under legal guardianship, tutorship or curatorship. * patient to whom it is impossible to give clear information * patient who is pregnant, about to give birth or breastfeeding.
study of the immediate and long-term outcomes of the disease in patients with left ventricular aneurysm complicated and uncomplicated by thrombosis after transmural myocardial infarction, according to the hospital registry: sibyl

Conditions: Myocardial Infarction

Summary: a prospective non-interventional study aimed to evaluate the immediate and long-term outcomes in patients with left ventricular aneurysm after transmural myocardial infarction. a registry of patients with transmural myocardial infarction admitted to the emergency department of cardiology will be created. the registry will include all consecutive hospitalized patients from from january 1, 2021 to december 31, 2021 who meet the inclusion criteria based on this registry, patients will be divided into groups : patients with left ventricular aneurysm and patients without aneurysm, patients with left ventricular thrombosis and patients without thrombosis. patients will be contacted in 3 and 12 months. surviving patients will be invited to appointment for an ecg, echocardiography and survey. the cardiovascular events during this period will be recorded. the factors determining the prognosis of patients and their concomitant diseases, immediate and long-term prognoses, therapeutic measures and drug therapy at the hospital and outpatient stages, and patients ' adherence to therapy will be analyzed.


Eligibility criteria:
inclusion criteria: 1. men and women who had acute transmural myocardial infarction and who were hospitalized to the emergency cardiology department of the n. v. sklifosovsky research institute of emergency medicine from january 1, 2021 to december 31, 2021 2. patients from 18 to 85 years of age 3. patients who live in moscow and moscow region 4. patients who signed the consent to participate in the study and processing of personal data. exclusion criteria: 1. patients who refused to come for a second appointment or answer the questionnaire questions 2. patients who had repeated myocardial infarction 3. non-compliance with inclusion criteria

Keywords: left ventricular aneurysm, transmural myocardial infarction
mobile health self-management and support system for chronic and complex health conditions

Conditions: Spinal Cord Injuries; Cerebral Palsy; Spinal Dysraphism; Brain Injuries; Spina Bifida; Traumatic Brain Injury

Summary: this study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with spinal cord injury,cerebral palsy, spina bifida, and traumatic brain injury) to improve their wellness and self-management skills compared to those who receive standard of care only.

individuals with chronic and complex conditions such as those with spinal cord injury (sci),cerebral palsy (cp), spina bifida (sb), and traumatic brain injury (tbi), often require complex self-management routines to manage various needs such as bowel and bladder, skin integrity, and general health and wellness. tasks such as self-catheterization, bowel regimens, skin checks, and routine administration of medications require consistent follow-through to prevent complications. early detection and treatment of problems such as urinary tract infections (utis) or wounds, can prevent serious complications like osteomyelitis and sepsis which can result in hospitalization, death, and expensive medical care. the investigators have developed an innovative mobile health (mhealth) system aimed at improving self-management skills and preventing and detecting early signs of secondary medical complications. the system consist of a mobile health applications (apps), a clinician portal and a two-way secure communication system between the two. people with complex care regimens can use the apps to get reminders or cues to carry out their self care routines such as bowel/bladder routines, take medications, report success with their activities or new problems (e.g. new wound, uti symptoms etc.), and track symptoms of depression. a clinician can use the portal to view the report and communicate with the users through a secure communication system that is embedded in the apps. this study will assess the benefits of using the system in improving users' wellness and self-management skills compared to those who receive standard of care only.

Eligibility criteria:
inclusion criteria: 1. 12 years or older. 2. have a diagnosis of a chronic and complex condition such as spina bifida, spinal cord injury, cerebral palsy and traumatic brain injury, etc. 3. live in a community setting (not within a residential facility that provides care to them). 4. pass all the functional screening tests which include basic usage of a smart phone, and impairment severity assessments exclusion criteria: 1. diagnosis of severe intellectual disability or severe and persistent psychiatric illness. 2. failing all the screening tests due to severe impairments that cannot be accommodated by the mhealth system (for patient participants)

Keywords: mobile health apps applications smart phone mhealth chronic and complex conditions self-management self-care
exercise and insulin signaling in human skeletal muscle

Conditions: Insulin Sensitivity; Obesity; Sedentary Lifestyle

Summary: obesity is associated with a decrease in skeletal muscle insulin sensitivity. aerobic exercise can increase insulin sensitivity in the few hours following exercise, however the cellular mechanisms are not completely understood. the current project is to investigate mechanisms of exercise improvements to skeletal muscle insulin sensitivity.

study overview: we are investigating the mechanisms by which exercise improves the response of skeletal muscle to insulin in lean and obese adults. participants will complete 4 study visits consisting of: 1) screening visit, 2) maximal exercise test visit, and then a randomized order of 3) a resting metabolic study visit, and 4) an exercise metabolic study visit. metabolic study visits for resting and exercise conditions will be identical, other than remaining sedentary or performing exercise. skeletal muscle biopsy samples will be collected during resting, immediately post-exercise and during insulin stimulated conditions.

Eligibility criteria:
inclusion criteria: * males or females * aged 18-45 years * normal weight (body mass index \[bmi\] 18-26 kg/m2) or obese (bmi 30-46 kg/m2) * sedentary (\< 1 hour of planned physical activity per week for ≥ 6 months) * weight stable (\< 2 kg change in body mass for ≥ 6 months) * non-smokers (no tobacco or nicotine use for ≥ 1 year) exclusion criteria: * hypertension (systolic blood pressure \>140 mmhg, diastolic blood pressure \> 90mmhg) * chronic health condition including diabetes, cardiovascular disease, treated hypertension, cancer, anemia, uncontrolled hyper- or hypothyroidism. * pregnant, nursing, irregular menses or post-menopausal (if female) * hyperglycemia (fasting glucose \>126 mg/dl) * hypercholesterolemia (fasting ldl\>140mg/dl) * hemoglobin \< 13.0 g/dl (males), \< 11.5 g/dl (females) * compromised renal function (outside 135-145 mmol/l sodium, 3.5-5.1 mmol/l potassium) * lidocaine allergy * medications including β-blockers, angiotensin converting enzyme inhibitors, insulin, thiazolidinediones, metformin, sulfonylureas, chronic non-steroidal anti-inflammatory use, anti-coagulant (e.g. warfarin), current antibiotics, opiates, monoamine oxidase inhibitors, benzodiazepines, or others that may impact the study outcomes * any physical limitation that prevents a participant from safely completing the exercise test * due to the risks associated with the current protocol, individuals with a diminished capacity to consent will be excluded. similarly, due to the need for constant, accurate participant monitoring during metabolic study activities, participants will need to clearly understand verbal and written english. participants who cannot clearly understand verbal and written english will be excluded.

Keywords: exercise
low-grade inflammation and gut symptoms from a2 and hydrolyses a1 milk

Conditions: Milk Intolerance

Summary: the aim of this study is to reveal how different forms of milk casein, lactose and moderate breakdown of proteins affect the symptoms that may arise from milk and markers of inflammation in volunteers receiving symptoms from milk. research hypotheses are: 1) protein hydrolyzed milk is as tolerated or better tolerated than a2 milk, and 2) lactose is the main causative agent of stomach symptoms in milk-sensitive individuals.


Eligibility criteria:
inclusion criteria: * perceive disturbing gut symptoms from regular milk * commits to the research diet for the whole research period * age: 18-65 * bmi: 18.5-30 * healthy (normal kidney, liver and thyroid function and self-reported) exclusion criteria: * milk allergy * regular medication (other than contraceptives) or medication affecting the gut * recent course of antibiotics (\< 3 months prior the study) * pregnancy or lactation * diagnosed bowel disease
contributing factors to anterior resection syndrome and its impact on quality of life: a retrospective cohort study

Conditions: Low Anterior Resection Syndrome; Cancer; Quality of Life

Summary: this study adds to the understanding of the contributing factors leading to lars, the long term effects of this syndrome post-operatively and its impact on quality of life.


Eligibility criteria:
inclusion criteria: * all adult patients \>18 years, under the care of all surgical firms at mater dei hospital, who had undergone anterior resection for rectal cancer between january 2014 and december 2016 exclusion criteria: * colorectal cancer (\>15cm) from anal verge * permanent stoma * known disseminated or recurrent disease, * patient without restitution of bowel continuity after 1 year
randomized trial for botox urinary incontinence

Conditions: Urinary Incontinence

Summary: the purpose of this study is to determine how effective botox is in reducing the amount of urine leaked and which dose of botox is more effective and safe in those who have urinary urge incontinence.

the prevalence of urinary incontinence in the us ranges from 3-14% with epidemiologic estimates ranging widely.1 most urinary incontinence can be categorized into stress urinary incontinence (sui) or uui with uui remaining more common and debilitating than sui.2 a major cause of uui is overactive bladder or detrusor instability (di), and while di is very common, its etiology remains unknown. di is often successfully managed with behavioral therapy, physical therapy, medications and surgery with the most effective therapy being anticholinergic medication.2 however, side effects including dry mouth, and constipation often lead to discontinuation of these drugs. in addition, many patients fail anticholinergic medication and have persistent urinary leakage. women who fail these treatments have limited options.

Eligibility criteria:
inclusion criteria: subjects must have all of the following: * completed a routine evaluation of incontinence (urodynamics, bladder diaries, and pad weights) through the urogynecology clinic at smh within 3 months of the screening visit * symptoms of urge incontinence associated with leakage on bladder diary * 24-hour pad weight \>100 cc's (volume requiring multiple daily diaper changes) * absence of a bladder infection or other condition that could explain urinary leakage * absence of stress incontinence or a cough leak point pressure \> 100 cm h2o on cystometry (this correlates with mild stress incontinence) * failed anticholinergic therapy * willingness and ability to perform intermittent clean catheterization (due to the risk of prolonged urinary retention from botox) * the ability and willingness to return for surveillance evaluations * a negative urine pregnancy test if at risk for pregnancy * competent to give signed consent and complete all of the study measures exclusion criteria: * children (\< 21 years old), pregnant women and prisoners * history of carcinoma of the bladder * absence of a measurable detrusor contraction on a pressure flow micturition study * a foreign body in the bladder or other correctable etiology for the uui * prior documented resistance to botox * gross fecal incontinence (due to confounding effects on pad weights and counts) * known allergy to lidocaine or related compounds (used for local analgesia) * known allergy to or inability to take both bactrim ds or ciprofloxacin (used for urinary tract infection prophylaxis) * current use of an aminoglycoside or preparing for general anesthesia within 1 week (risk of synergetic effects * known neurologic conditions such as parkinson's disease, myasthenia gravis, multiple sclerosis, autonomic dysfunction, lambert-eaton syndrome, amyotrophic lateral sclerosis or other neurologic disorder that may impact urinary function or the effect of botox.
cueing and pilates in low back pain

Conditions: Low Back Pain; Pilates Exercise; Pilates, Core Stability; Mind-body Exercise

Summary: the intervention involved two groups participating in supervised pilates sessions, twice a week for 8 weeks, featuring a mix of mat and props-based exercises. group 1 received additional cueing training to enhance alignment, muscle engagement, and movement technique, while group 2 underwent the same pilates regimen without this cueing component.

the study involved two distinct groups, both of which engaged in pilates sessions lasting for 60 minutes, held twice a week over eight weeks. these sessions were meticulously overseen by certified pilates instructors, who brought to the table a wealth of experience. the regimen for the pilates program was comprehensive, incorporating a blend of exercises performed on mats and with the aid of various props. the first group, pilates with cueing, consisted of participants who, before starting the main pilates sessions, were given additional training. this preliminary phase involved two smaller group sessions where the focus was on learning explicit verbal and tactile cueing. these cues were specifically designed to aid participants in maintaining proper body alignment, engaging the correct muscle groups effectively, and refining their overall movement technique. throughout the pilates sessions, instructors provided real-time feedback, aiming to optimize the execution of exercises based on these cues. the second group, known as pilates without cueing, participated in an identical pilates program to that of the first group in terms of the exercises performed, the duration of sessions, and the overall timeframe. however, this group did not receive the preliminary cueing instruction. they performed the pilates exercises following the same program as the first group but without the added focus on cueing for alignment, muscle engagement, and technique refinement.

Eligibility criteria:
inclusion: * individuals aged 18 to 65 years. * experiencing chronic non-specific low back pain for a minimum of 3 months. * ability to participate in supervised exercise programs. * absence of medical contraindications for pilates practice. exclusion: * vestibular disorders. * severe osteoporosis. * usual pilates practitioner.

Keywords: pilates low back pain mind-body
multiomics biomarkers for urolithiasis

Conditions: Urolithiasis

Summary: this is a prospective case series study. to compare urine sample of recurrent stone-formers and non-stone former by multiomics approach to identify potential markers for stone recurrence.

a total of 100 chinese patients with history of recurrent urinary stone and no history of urinary stone disease (control) will be recruited for the study. urine will be saved for multiomics analysis, including metabolomics, proteomics, etc. thereafter, integrated multiomics calculation of recurrent stone can be studied for the differentiation of recurrent stone former and non-stone former. after completing the preliminary and screening experiments, a large validation cohort (1000 chinese patients with history of recurrent urinary stone) will be carried out. the patients will then be follow-up in clinic for at least 3 years, with minimum annual review and imaging to detect for any stone recurrence, as defined as increase in stone size and number, or symptomatic stone events. targeted biomarkers measurement, based on part 1 result, will be done and the result will be used to correlated with the clinical outcomes of stone recurrence.

Eligibility criteria:
inclusion criteria: * patients with history of recurrent urinary stone * age greater than or equal to 18 years old * have more than 2 episodes of radio-opaque stone disease (bilateral stones were counted as two episode) patients with no history of urinary stone disease * age greater than or equal to 18 years old * with no history of urinary calculi, from history and imaging. exclusion criteria: * patient refused or unable to provide consent for the study * patient with active urinary infection * patient with radiolucent stone or infective stone * patients with no history of urinary stone disease (for control group) * patient refused or unable to provide consent for the study * patient with active urinary infection