evaluation of autogenous stored versus autogenous fresh mineralized dentin graft for alveolar ridge preservation

Conditions: Alveolar Bone Loss

Summary: tooth extraction triggers a cascade of biological events mediated by both the local inflammatory response that follows the surgical intervention and the deprivation of masticatory stimulation of the periodontium, which elicit an alteration of the homoeostasis and structural integrity of the periodontal tissues. bone remodeling kicks off after tooth loss and continues for several months with most changes taking place in the first three months. interestingly, schmidt-schultz and schultz, found that intact growth factors are conserved even in the collagenous extracellular matrix of ancient human bone and teeth. thus, the application of stored dentin may have similar benefits as fresh dentin, preserving intact growth factors for a prolonged period avoiding the need to perform multiple surgical interventions simultaneously. the volume of the particulate dentin is more than twice of the original root volume. thus, the idea of using autogenous stored mineralized dentin grafts (asmdg) in arp evolved.

immediately following tooth extraction, the alveolar ridge comes across its normal physiologic healing process that results in respective alveolar bone loss, structural and compositional changes of the covering soft tissues, as well as morphological alterations. in an attempt to cutback horizontal and vertical ridge losses, various techniques have been successfully proven to preserve the alveolar ridge including autografts, allografts, xenografts, alloplasts and autogenous dentin grafts. however, fresh autogenous bone graft is still considered gold standard since it exhibits bioactive cell instructive matrix properties and is non-immunogenic and non - pathogenic in spite of the need for harvesting bone and possible morbidity resulting from it. nevertheless, no gold-standard technique is applicable for every clinical situation. the similarities between dentin and alveolar bone may help the human body to show an acceptable biological behavior to dentin graft. it is therefore not surprising that dentin that comprises more than 85% of tooth structure can serve as a native bone grafting material, which is reflected by the interaction between mineralized dentin and osteogenic cells that attach and produce mineralized bone matrix directly on the dentin graft. mineralized dentin particles have the advantage to maintain its mechanical stability, allowing early loading after grafting in fresh sockets and bone defects where the mineralized dentin is firmly integrated with newly formed bone, creating a solid site for anchorage of dental implants. fresh ground dentin has been used successfully as a grafting material alternative in alveolar ridge preservation which has been manifested in that the clinically grafted sites demonstrated limited ridge resorption which allowed for subsequent implant placement without the need to use additional graft biomaterials.

Eligibility criteria:
inclusion criteria: * potential candidates requiring extraction of maxillary non-molar teeth. * periodontally healthy adjacent teeth. * extraction sockets having no more than 50% of buccal alveolar bone loss exclusion criteria: * smokers. * patients reporting systemic conditions that may compromise healing or bone metabolism (e.g., uncontrolled diabetes, hyperthyroidism). * patients having a history of radiotherapy, chemotherapy, or bisphosphonate therapy. * females who were pregnant or planning to get pregnant during the study course. * root canal treated teeth and teeth with acute infection at the site of extraction