Kornimate/medical-research-clean huggingface dataset:
auriculotherapy effectiveness on stress and anxiety in nursing student

Conditions: Stress; Anxiety

Summary: single-blind randomized controlled trial aimed to assess stress and anxiety levels in nursing school students of beneficence portuguese hospital and review the effectiveness of true and placebo auriculotherapy.

although researches on stress have a strong focus on stress at work,it is very important the evaluation of the stress and its consequences in nursing students. this allows to understand which stress factors experienced in a negative way could interfere on the adaptive success in school activities. students can experience symptoms of the alarm phase of stress such as tachycardia, muscle tension, skin and cold extremities, and also the second phase of stress such as headache, sleepiness, irritability and difficulty concentrating. high levels of stress have a substantial effect on attention and can lead to errors, lack of concentration and fluctuations in the level of attention. the auriculotherapy may have an important role as a coping strategy for stress and anxiety. it is a fast, relatively simple, easily performed, safe and without major side effects.

Eligibility criteria:
inclusion criteria: * average and high score by the list of stress symptoms * voluntary participation in the study * availability of time for submission to the sessions exclusion criteria: * pregnancy * medical license or vacation during the period * low score of stress

Keywords: stress disorders anxiety disorders
pelvic floor muscle training for incontinence in older women.

Conditions: Stress Urinary Incontinence

Summary: to determine the effect of pelvic floor muscle training in women aged 70 years and over, who have proven stress urinary incontinence. the hypotheses to be tested are: 1. that pelvic floor muscle training is effective in relief of symptoms of stress urinary incontinence as measured by a greater reduction in the number of episodes of incontinence, quantity of urine lost and improvement of quality of life. 2. that women who undertake pelvic floor muscle training will show greater improvement of pelvic floor muscle function than women who have behavioural (bladder) training, as measured by real time transabdominal ultrasound.

urinary incontinence is associated with significant personal stress, shame and social stigma and affects around one-third of women over 60 years of age. it restricts the amount of physical activity and can lead to social isolation and poor health. pelvic floor muscle re-education by physiotherapists is the most commonly recommended method of conservative management. although a recent cochrane review concluded that it was an effective treatment for women with stress and mixed incontinence, there is still no strong evidence for the effectiveness of this intervention in elderly women. it has also been suggested that bladder training alone is equally effective in patients with stress urinary incontinence, urge and mixed incontinence. this is contrary to current clinical experience. it is therefore important to distinguish the relative effectiveness of these interventions used in isolation in order to ensure that urinary incontinence is managed in the most effective and efficient way. comparisons: pelvic floor muscle training group and bladder training. assessments will be conducted at baseline, 1 month, 3 months and 5 months during the intervention period. both groups will then continue with their home program for a further 7 months until their final assessment (assessment 5). outcome measures will include: volume of urine lost during a stress test, completion of accident diaries, degree of 'bother', quality of life using the kings health questionnaire, and assessment of pelvic floor function using real time transabdominal diagnostic ultrasound.

Eligibility criteria:
inclusion criteria: * community-dwelling women aged over 65 years * urodynamically proven stress incontinence * medically stable exclusion criteria: * already receiving physiotherapy intervention * neurogenic incontinence * cannot comply with training program

Keywords: stress urinary incontinence pelvic floor muscle training bladder training older women
trial of arm sleeve and forearm fatigue during robotic surgery

Conditions: Ergonomics

Summary: the study objective was to investigate whether wearing a forearm compression sleeve during robotic surgery reduces muscle fatigue as measured objectively by a grip strength dynamometer.


Eligibility criteria:
inclusion criteria: * robotic surgeon exclusion criteria: -
evaluation of pku start

Conditions: Phenylketonuria; Inborn Errors of Metabolism

Summary: to evaluate the acceptability, tolerance and effect on metabolic control of pku start, a new phe free protein substitute for the dietary management of pku in infants from birth.

this is an assessment of ten (10) infants who require a protein restricted diet that is low in phe. infants who routinely use a phe free infant formula as part of their dietary therapy will be recruited for a 28-day assessment of pku start, to evaluate tolerance and acceptability. the outcome of this assessment will be used in a submission to the regulatory authorities, advisory committee on borderline substances (acbs), for pku start to become reimbursable on prescription in the uk. the participant's dietitian will advise on an appropriate amount of pku start based on individual requirements. parents/carers will be asked to substitute their usual phe-free infant formula with pku start for one (1) month. the sponsor will supply pku start free of charge. prior to starting pku start, parents/carers will be asked to record information about the infant's usual gi tolerance and feeding pattern for a period of three (3) days, to allow for comparison between their existing formula and pku start. they will be asked to record information about the following: stools vomiting and spit-up feed / fluid intake and compliance phenylalanine levels final evaluation about the presentation of the product, ease of preparation and how pku start flowed through the teat of a bottle.

Eligibility criteria:
inclusion criteria: 1. a diagnosis of classical or severe pku on new-born screening (for the purposes of this study, 'severe' is defined as phe concentrations between 120 and 600 µmol/l at diagnosis) 2. taking a minimum of one (1) feed of a phe-free infant formula 3. a minimum period of four (4) weeks from the time of diagnosis to initial approach to parents exclusion criteria: 1. diagnosed with mild pku or hyperphenylalaninaemia (for the purposes of this study, 'mild' is defined as phe concentrations between 120 and 600 µmol/l at diagnosis) 2. diagnosis of a congenital condition

Keywords: phenylketonuria pku metabolism metabolic control acceptability
self-acupressure for insomnia

Conditions: Insomnia; Acupressure

Summary: abstract objectives: to explore the clinical effects of self-acupressure for treating insomnia delivered by a training course. hypothesis: subjects who have participated in the self-acupressure training course will have greater improvement in insomnia symptoms and daytime impairment than the sleep hygiene education control group at 4 and 8 weeks. design and subjects: a pilot randomized controlled trial. subjects with insomnia will be recruited from the community. 30 subjects will be randomized to self-acupressure and sleep hygiene education control groups in a 1: 1 ratio. study instrument: insomnia severity index (isi) will be used to assess insomnia symptoms and daytime impairment. interventions: subjects in the self-acupressure group will attend two training sessions to learn self-acupressure and will practice self-acupressure every night for 4 weeks; subjects in the sleep hygiene education control group will receive two training sessions to learn sleep hygiene practice. main outcome measures: the primary outcome measure is the isi score. other measures include sleep parameters using subjective sleep diary, hospital anxiety and depression scale, and sf-6d at 4 and 8 weeks. acceptability and sustainability of self-acupressure will also be evaluated. data analysis: differences in the questionnaire scores, subjective sleep parameters will be examined using a mixed-effects model.


Eligibility criteria:
inclusion criteria: * (1) chinese hong kong residents who are able to communicate in cantonese or putonghua; * (2) aged 18 - 65 years; * (3) a current clinical diagnostic and statistical manual of mental disorders, fifth edition (dsm-5) diagnosis of insomnia disorder according to the brief insomnia questionnaire (biq), a validated diagnostic tool. (the criteria include having difficulties in falling asleep, difficulties in staying asleep, or early morning awakening with clinically significant consequences for daily life for at least 3 months.) * (4) insomnia severity index total score of at least 10 indicating insomnia at the clinical level; and * (5) willing to give informed consent and comply with the trial protocol. exclusion criteria: * (1) receiving acupuncture or practitioner-delivered acupressure treatment in the past 6 months; * (2) pregnancy; * (3) cognitive impairment as indicated by a mini mental state examination ≤ 23; * (4) at significant suicidal risk as rated by the hamilton depression rating scale item on suicide (score ≥ 3); * (5) no comorbid sleep disorders primarily requiring other treatment, such as sleep apnea or narcolepsy; and * (6) taking herbal remedies, over-the-counter medication, or psychotropic drugs that target insomnia within the 2 weeks prior to baseline.

Keywords: insomnia randomized controlled trial acupressure self-help
hdp vs ns intra-articular injection among koa with obese patient

Conditions: Knee Osteoarthritis; Obesity

Summary: the aim of this randomized controlled trial study was to compare the effect of intra-articular injection of hypertonic dextrose prolotherapy (hdp) with normal saline (ns) in the clinical improvement of knee osteoarthritis (koa) patients with comorbid obesity. the main questions to be answered are: * how does the effect of hdp versus ns intra-articular injection compare to the numerical rating score (nrs) in obese koa patients? * how does the effect of hdp versus ns intra-articular injection compare to scores of the western ontario and mcmaster universities arthritis index (womac) in obese koa patients? * how does the effect of hdp versus ns intra-articular injection compare to the thickness of the femoral cartilage in obese koa patients? participants who meet the inclusion and exclusion criteria will be randomized based on the order of the outpatient department each day, with odd numbers as the hdp intervention group and even numbers as ns. they received ultrasound-guided intra-articular injections on day 1 and day 30. researchers will compare hdp versus ns groups to see which group improves nrs, womac, and femoral cartilage thickness.

this is a randomized controlled study, which recruited koa patients with obese comorbidity who were treated at the outpatient department of physical medicine and rehabilitation at rumah sakit daerah haji provinsi jawa timur, surabaya, indonesia from may to august 2023. the participants were divided into two groups, including hdp versus ns injections. each study participant's identity including age, gender, weight, height, and bmi was recorded. then an evaluation of the nrs, womac score, and femoral cartilage thickness was carried out using ultrasound. this study assessed using the nrs scale for pain reduction on a scale of 0 to 10 (0 means no pain, while 10 means very pain). the womac score consists of 24 questions with four scales, namely 0: none, 1: mild, 2: moderate, 3: severe, and 4: very severe. femoral cartilage thickness scan using ultrasound with millimeter units.

Eligibility criteria:
inclusion criteria: * patient was diagnosed with knee osteoarthritis (koa). * patient was diagnosed with obesity. exclusion criteria: * patient with a history of knee trauma. * patient with a history of knee surgery. * patient with a history of intra-articular injection before.

Keywords: knee osteoarthritis obesity
hip peak torque in running and jumping activities in healthy active subjects

Conditions: Hip Injuries

Summary: hip-related groin pain is common in sports that involves change of direction, kicks and sprint accelerations such as football, ishockey, tennis and basketball. groin pain symptoms either pre- or post-treatment may be load-related, there is limited information on how different sporting activities affect hip joint loading. thus, the purpose of this explorative cross-sectional study is to investigate hip peak torque in running and jumping activities in healthy active subjects. such information may guide furture rehabilitation strategies and return to sport sport criteria. twenty healthy subjects from the capital region of denmark with an age of 18-40 will be included. hip joint kinetics and kinamatics will be obtained during the following activities for each subjects: 1. walking 2. jogging (8-11 km/h) 3. maximal 6 meters sprint acceleration 4. single leg drop jump from 35 cm height 5. horizontal jump with single leg landing with a distance of 100% and 150% of leg length 6. maximal change of direction at 45, 135, 180 degrees 7. single-leg cross-country skiing exercise


Eligibility criteria:
inclusion criteria: * subjects who are healthy and physically active. exclusion criteria: * any history of lower limb surgery or fracture * lower limb injuries, joint or muscle pain with a duration of more than 6 weeks within the past year. * body mass index more than 30 kg/m2
imaging ccr2 receptors with 64cu-dota-ecl1i in head and neck cancer

Conditions: Head and Neck Cancer

Summary: ccr2 is a significant prognostic biomarker in head and neck cancer. currently there is no clinical biomarker to study ccr2, its prognostic significance or to select patients for ccr2-targeted therapy and to monitor response to such therapy. the investigators have developed a ccr2 specific pet radiotracer based on the peptide, ecl1i (d(lgtflkc)) and radiolabeled with 64cu (64cu-dota-ecl1i). the investigators have found that 64cu-dota-elc1i specific binding has been demonstrated in human head and neck cancer tissue.


Eligibility criteria:
inclusion criteria: * adult patient 18 years of age or older * cytology or biopsy-proven squamous cell head and neck cancer scheduled to be treated with standard of care surgery. patients who are not surgical candidates should have adequate tissue from tumor biopsy for analysis of ccr2 * lesion size of at least 1.5 cm (treatment naïve) * able to give informed consent * not currently pregnant or nursing: subject must be surgically sterile (has had a documented bilateral oophorectomy and/or documented hysterectomy), post menopausal (cessation of menses for more than 1 year), non-lactating, or of childbearing potential for whom a urine pregnancy test (with the test performed within the 14 hour period immediately prior to administration of 64cu-dota-ecl1i is negative exclusion criteria: * patients with other invasive malignancies, with the exception of non-melanoma skin cancer, who had (or have) any evidence of the other cancer present within the last 2 years * unable to tolerate approximately 90 minutes (total time) of pet/ct imaging
stem cells and resynchronization cardiac

Conditions: Heart Failure

Summary: same patients with dilated myocardiopathies with large areas of fibrosis has not been as successful after cardiac resynchronization therapy, for heart failure patients in functional class iii or iv. therefore the investigators have decided to associate the stem-cell implant with cardiac resynchronization therapy in these patients.

about 120cc of blood are collected from the iliac bone marrow under epidural anesthesia.in the cell therapy lab this blood is harvested and mononuclear cells are separated.this procedure takes roughly 4 hours.after dilution the mononuclear cells are injected into the cardiac muscles with fibroses area through 20 shots.this procedure is indicated for patients with cardiac ischemia and left ventricular dysfunction(desynchrony), on whom all the others known therapies have failed.

Eligibility criteria:
* dilated cardiomyopathy * heart failure * optimized therapeutics * ventricular desynchrony * functional class iii or iv * ejection fraction(echo/ sympson) \< 35%

Keywords: cardiac resynchronization dilated cardiomyopathy stem cells therapy heart failure stem cells/cardiac pacing, artificial
cetaphil® daily facial moisturizer with sunscreen spf 50+ - human repeat insult patch test

Conditions: Skin Irritation

Summary: this study examined the possible sensitization and irritation effects of a moisturizer with sunscreen spf 50+.

the design for this study is standard for human repeat insult patch tests. to test the moisturizer with sunscreen spf 50+ for the potential to induce contact sensitization by repetitive applications, healthy subjects received 9 applications at 48 to 72 hour intervals of the moisturizer to the upper back. patches were remained on the skin for approximately 48 to 72 hours. twelve to 24 days after the previous applications, subjects were patched with the moisturizer at the original site and an alternative site for 48 hours.

Eligibility criteria:
inclusion criteria: * men or women 18 to 70 years of age in general good health * can read, understand, and sign informed consent exclusion criteria: * history of acute or chronic disease * diagnosed with chronic skin allergies * pregnant or lactating

Keywords: cetaphil daily facial moisturizer with spf 50+ hypoallergenicity skin irritation
the effectiveness of different exercises in scoliosis

Conditions: Scoliosis; Adolescent Scoliosis

Summary: the aim of this study is to examine the effectiveness of stabilization exercises integrated with schroth exercises on quality of life, trunk rotation angle, body awareness and sleep quality in young people with scoliosis.

the study will include adolescents who come to bursa eforfiz healthy living center for outpatient treatment. participants will be selected from adolescents between the ages of 10-17. participants will first read the voluntary consent form and if they agree to participate in the study, they will then be evaluated by a physiotherapist. first, the demographic information of the participants will be questioned and then the evaluation will be done in a single session. participants will be randomly divided into two groups. these will be the control group and the exercise group. both groups will perform the determined exercises for 8 weeks in a private clinic with a physiotherapist. only scales, forms and surveys with turkish reliability and validity studies will be used in the evaluation methods. the surveys will be uploaded to the digital environment and filled in with the physiotherapist according to the participant's answers. all collected data will be scored by the physiotherapist in accordance with the scoring systems and the obtained data will be evaluated using the spss program.

Eligibility criteria:
inclusion criteria: * being between 9-17 years of age * having a primary curve between 10-40 degrees according to the cobb method * having typical s or c scoliosis * being willing to participate in the study * having the cognitive capacity to cooperate with the guidance of a physiotherapist exclusion criteria: * having a bmi over 30 kg/m2 * having any neurological, orthopedic, cardiopulmonary disorders other than the diagnosis of scoliosis * having had any injuries related to the musculoskeletal system in the last 6 months * being unable to fulfill exercise requirements for any reason
the safety and efficacy of ffr protocol in ntuh system

Conditions: Bradyarrhythmia; Dyspnea; Acute Respiratory Failure

Summary: ffr-guided pci has been performed in national taiwan university hospital(ntuh) for many years. nevertheless, the method of ffr measurement in ntuh is different from that in literature. in this study, the investigator would like to evaluate the effectiveness and safety of ntuh experience in ffr prospectively. first, the investigator will record any intracoronary (ic) injected adenosine-related complications, such as bradyarrhythmia or chest discomfort. second, the investigator will follow up on the clinical outcome of the participants for 2 years, record if any target lesion failure, target vessel failure, target vessel-related myocardial infarction, and cardiac death. finally, left ventricular diastolic pressure, serum pro-brain natriuretic peptide (pro-bnp), and high sensitivity c- reactive protein (hscrp) will be checked and determined their relationships with the maximum dosage of ic adenosine.

ffr has been introduced for the determination of physiological ischemia in the myocardium for many years. nowadays, ffr-guided pci is highly recommended for the assessment of physiologic ischemia in intermediate coronary lesions. ffr-guided pci has been performed in national taiwan university hospital(ntuh) for many years. nevertheless, the method of ffr measurement in ntuh is different from that in literature. in this study, the investigator would like to evaluate the effectiveness and safety of ntuh experience in ffr prospectively. first, the investigator will record any intracoronary (ic) injected adenosine-related complications, such as bradyarrhythmia or chest discomfort. second, the investigator will follow up on the clinical outcome of the participants for 2 years, record if any target lesion failure, target vessel failure, target vessel-related myocardial infarction, and cardiac death. finally, left ventricular diastolic pressure, serum pro-brain natriuretic peptide (pro-bnp), and high sensitivity c- reactive protein (hscrp) will be checked and determined their relationships with the maximum dosage of ic adenosine.

Eligibility criteria:
inclusion criteria: * eligible for ffr examination exclusion criteria: * hypersensitivity to adenosine * severe valvular aortic stenosis * resting heart rate less than 50 beats per minute
retrospective follow-up study of synvisc® in patients with knee osteoarthritis

Conditions: Osteoarthritis

Summary: retrospective collection of data, aimed at a better knowledge of the use of synvisc® among the patients with knee osteoarthritis (oa) since at least three years.


Eligibility criteria:
inclusion criteria: * patients with knee osteoarthritis using synvisc® since at least three years exclusion criteria: * none
effect of pioglitazone on the course of new onset type 1 diabetes mellitus

Conditions: Type 1 Diabetes Mellitus

Summary: a study to examine the effect of pioglitazone on the course of new onset type 1 diabetes mellitus.

thiazolidinediones have been shown to reduce the development of diabetes mellitus in animal models of type 1 diabetes and to reduce the death of beta cells (cells that make insulin) in petri dishes. pioglitazone is a thiazolidinedione currently approved for the treatment of type 2 diabetes. this study explores the question of whether pioglitazone can preserve beta cell function in patients with recently diagnosed type 1 diabetes mellitus.

Eligibility criteria:
inclusion criteria: * patients with type 1 diabetes mellitus diagnosed within 4 months * age \> 6 years of age * ability to swallow capsule * signed informed consent / assent exclusion criteria: * other illnesses

Keywords: type 1 diabetes insulin dependent diabetes juvenile onset diabetes pioglitazone