Kornimate/medical-research-clean huggingface dataset:
johns hopkins weight management center patient data

Conditions: Obesity

Summary: patient records from johns hopkins weight management center historical files

examination of historical patient files from the johns hopkins weight management center, to be conducted by a study team led by the attending physician and director of the center. analyses will examine weight-related outcomes based on participation in the weight management center program.

Eligibility criteria:
inclusion criteria: * enrolled as a patient at the johns hopkins weight management center exclusion criteria: * none

Keywords: obesity
a trial of neoadjuvant mfolfoxiri versus crt in the emvi positive larc

Conditions: Locally Advanced Rectal Cancer

Summary: extramural vascular invasion positive(emvi+) is a high risk of distant metastasis for locally advanced rectal cancer(larc) after resection. the study is to evaluate the efficacy and safety of folfoxiri as neoadjuvant chemotherapy alone for emvi+ larc in contrast to the efficacy of standard chemoradiotherapy (crt).

it is an investigator-initiated, multicentered, randomized controlled clinical study to evaluate the efficacy and safety of mfolfoxiri as neoadjuvant chemotherapy alone for emvi+ larc in contrast to standard chemoradiotherapy. patients of larc with emvi+ evaluated by pelvic magnetic resonance imaging (mri) are enrolled in this trial. all patients will be randomized divided into two groups. experimental group will receive 3 cycles of mfolfoxiri, followed to be performed mri to assess clinical response. if the tumor response is good enough (partial response or complete response), the patient will receive another 3 cycles of mfolfoxiri then surgery. on the contrary, if the tumor shows poor response (stable disease or progressive disease) or with mesorectal fascia-positive or yct4a/b after re-evaluation, radiotherapy will be performed combined with capecitabine before operation. control group will receive standard capecitabine based chemoradiotherapy. patients with mesorectal fascia-positive or yct4a/b after re-evaluation would receive radiation before surgery, whereas responders would have immediate total mesorectal excision (tme). all patients will receive 4 cycles of xelox as adjuvant chemotherapy after tme.

Eligibility criteria:
inclusion criteria: 1. aged ≥ 18 to 70 years at diagnosis; 2. ecog status 0-2; 3. diagnosis of rectal adenocarcinoma(distal border of the tumor must be located \< 12 cm from the anal verge); 4. mri examination diagnosed emvi-positive; 5. tumor amenable to curative resection; 6. adequate bone marrow, hepatic and renal function as assessed by the following laboratory requirements conducted within 7 days of starting study treatment: (1) neutrophilic granulocytes ≥ 3.0 x10\^9/l, platelet count ≥ 75 x 10\^9/l, hemoglobin (hb) ≥ 90g/l; (2) bilirubin ≤1.5 x the upper limit of normal (uln),alanine aminotransferase (alt)/aspartate aminotransferase (ast) ≤ 2.5 x uln; (3) serum creatinine ≤ 1.5 x uln.no renal disease that would preclude study treatment or follow-up 7. signed informed consent; able to comply with study and/or follow- up procedures exclusion criteria: 1. hypersensitivity to fluorouracil, oxaliplatin or irinotecan; 2. patient had received pelvic radiotherapy; 3. patient had received systemic chemotherapy; 4. history of invasive colon or rectal malignancy, regardless of disease-free interval; 5. had metastatic disease; 6. patient had second malignant disease within 5 years; 7. uncontrolled co-morbid illnesses or other concurrent disease; 8. patients refused to signed informed consent. 9. pregnant and nursing women
effect of aerobic training on asthmatic patients

Conditions: Anxiety; Depression; Airway Inflammation

Summary: the investigators hypothesize that aerobic training can reduce anxiety, depression and airway inflammation and those benefits may be related to changes in autonomic system.

one-hundred patients with moderate or severe persistent asthma, age ranging from 20 to 50 years-old recruited after a medical consultation. asthma diagnosis based on gina1 and patients were under medical treatment for at least 6-months and considered clinically stable (no crises and changes in medication for at least 30 days). patients diagnosed with cardiovascular, pulmonary or musculoskeletal diseases impairing exercise training were excluded. experimental design: patients were studied between 2 medical consultation to avoid changes in medication during the study and patients were randomized (by drawing lots) into either control or training groups. cg was submitted to a 4-hour educational program and a breathing exercise program and tg was submitted to the same cg procedures plus an aerobic training program individually based on vo2max. before and after the intervention, patients performed pulmonary function test and cardiopulmonary exercise testing and as well as fulfilled questionnaires to quantify asthma specific hrql and anxiety and depression levels. asthma daily symptoms were evaluated monthly.

Eligibility criteria:
inclusion criteria: * 20-50 years old * moderate and severe asthma exclusion criteria: * other pulmonary or cardiovascular disease

Keywords: aerobic exercise exercise
community glaucoma screening follow-up

Conditions: Glaucoma

Summary: the purpose of this study is to determine if one of three interventions improves follow-up rates for screening exam participants who are instructed to have a definitive eye exam.

to determine if one of three interventions: vouchers, telephone calls, and personal contacts, improves follow-up rates for screening exam participants who are instructed to have a definitive eye exam.

Eligibility criteria:
inclusion criteria: * all who had an eye screening exam. exclusion criteria: * none

Keywords: glaucoma intervention follow up
mobile terminal based management of stroke secondary prevention adminstration effect research

Conditions: Stroke

Summary: the investigators want to verify whether mobile application based on stroke strengthen prevention management is more effective than traditional management model or open stroke management platform. whole blood-impedance based platelet aggregation(wba) method and verifynow detected by aspirin or clopidogrel responsiveness will provide individualized anti-platelet drug selection. endpoint event is defined as stroke death or relapse. primary measure outcomes are change of the stroke recurrence rate and mortality after secondary prevention.

with high incidence, mortality, morbidity and recurrence rate，stroke has significant impact on national development strategies planning. improving secondary prevention will strongly promote stroke management in the rapid developing phase of chinese economy and expansion of health situation. at present lack of high-quality medical resources, low medical permeability cannot remedy extensive prevention failure of stroke. mobile healthcare is easier to conduct and still in the early stage of explosive growth. this research group has established an open management platform of stroke prevention. and collaborate with peking university institute of information technology to develop a smart phone application which can be personalized medication reminder, record medication compliance, home blood pressure and blood glucose test results, also can provide doctor-patient communication platform and symptoms alarm. the investigators want to verify whether mobile application based on stroke strengthen prevention management is more effective than traditional management model or open stroke management platform. whole blood-impedance based platelet aggregation(wba) method and verifynow detected by aspirin or clopidogrel responsiveness will provide individualized anti-platelet drug selection. control group will be selected from the national stroke data registration database platform and open platform for stroke prevention. follow-up period is 2 years. endpoint event is defined as stroke death or relapse. primary measure outcomes are change of the stroke recurrence rate and mortality after secondary prevention.

Eligibility criteria:
inclusion criteria: * stroke exclusion criteria: * refusion in research

Keywords: stroke secondary prevention platelet response polymorphism mobile terminal
practice of fluid therapy in critically ill invasively ventilated patients

Conditions: Fluid Therapy; Vasopressor Therapy; Critical Illness; Invasive Ventilation

Summary: the goal of this woldwide observational study is to investigate various aspects of fluid and vasopressor therapy in critically ill invasively ventilated patients. the main questions it aims to answer are: * what is the global current practice of fluid and vasopressor therapy? * what are associations between this practice and clinical outcomes? participating intensive care units will gather detailed information about fluid and vasopressor therapy prescribed to participants. participating intensive care units will also gather information about participant outcomes such as duration of invasive ventilation, length of stay and mortality

rationale: the worldwide practice of fluid and vasopressor therapy in critically ill invasively ventilated patients is uncertain. indeed, it is unclear whether there is a difference in fluid and vasopressor therapy in these patients between low- and middle-income countries (lmics) and high-income countries (hics). objective: to determine various aspects of fluid and vasopressor therapy in critically ill invasively ventilated patients in lmics and hics. hypothesis: there is substantial worldwide variation in practice of fluid and vasopressor therapy in critically ill invasively ventilated patients. study design: international, multicenter, observational study in critically ill invasively ventilated patients; data are captured during a predefined period per geographic region or country. study population: critically ill invasively ventilated patients. nature and extent of the burden and risks associated with participation, benefit and group relatedness: because of the observational design of the study using routinely collected data, there is no additional burden for the patient. collection of data from icu charts or electronic medical records systems is of no risk to the patients.

Eligibility criteria:
inclusion criteria: * admitted to a participating intensive care unit; * receiving invasive ventilation; and * duration of ventilation \> 24 hours. exclusion criteria: * age \< 16 years; * patients transferred under invasive ventilation from another intensive care unit.

Keywords: fluid therapy vasopressor resuscitation deresuscitation fluids
coupling negative pressure wound therapy with instillation

Conditions: Wound; Ulcer; Burns

Summary: the objective of this study is to compare standard negative pressure wound therapy with negative pressure wound therapy coupled with instillation for optimal skin graft take. either the v.a.c ulta npwt or v.a.c. veraflo therapy systems with normal saline will be applied intra-operatively to split-thickness skin grafts of upper and lower extremity wounds and kept in place for a duration of four days. following completion of four days, the skin graft with be assessed for percentage of take/adherence and will be covered with simple gauze dressings as needed.

past studies have investigated the use of npwt for post-operative skin graft treatment and shown superior outcomes regarding graft take and need for repeat grafting when compared with standard gauze dressing. however, to date, no study has compared standard npwt to npwt coupled with instillation for post-operative treatment of extremity skin grafts. this study is designed as a randomized, controlled pilot study to compare treatment standard npwt with npwt coupled with instillation on skin graft take. patients will be selected based on inclusion criteria and randomized to either the treatment (npwt coupled with instillation) or the control group (standard npwt). depending on the group to which they are randomized to, patients will have standard npwt or npwt coupled with instillation applied intra-operatively after application of split thickness skin graft for treatment of extremity wound. patients randomized to control group will receive v.a.c ulta npwt at 125mmhg continuous pressure for duration of four days. patients randomized to treatment group will receive v.a.c veraflo therapy. protocol will consist of the following: * instillation solution: normal saline * dwell/soak time: 30 seconds * cycle time: 4 hours * pressure: 125mmhg the devices will be kept in place for four days, at which point, the wound vacs will be removed and the percentage of skin graft take will be evaluated with use of photometric analysis. the skin grafts will be subsequently dressed with gauze as appropriate. patients will be followed up in clinic to assess outcome of skin graft take.

Eligibility criteria:
inclusion criteria: * patients who have been offered split-thickness skin graft for treatment of an extremity wound. exclusion criteria: * abnormal healing (diagnosed with connective tissue disorder) * uncontrolled diabetes mellitus (hgba1c \>9)
very intensive variable repetitive ambulation training

Conditions: Stroke

Summary: the overall objective of this subproject is to evaluate the individual and paired contributions of intensity and variability of stepping training on lower extremity (le) function, health and community participation in patients with chronic hemiparesis post-stroke.

the overall objective of this subproject is to evaluate the individual and paired contributions of intensity and variability of stepping training on lower extremity (le) function, health and community participation in patients with chronic hemiparesis post-stroke. using a rct design/intervention efficacy paradigm, aim 1 will investigate the independent and combined (paired) contributions of intensity and variability of stepping training on locomotor function, with secondary measures of health and community mobility. for aim 2, we will evaluate the independent and combined effects of intensity and variability of stepping training on non-walking le tasks. in aim 3, we will evaluate the cost effectiveness of providing these interventions to accelerate motor recovery and health. our central hypothesis is that results of this study will provide a theoretical foundation for implementation of physical therapy interventions which can facilitate short-term gains in locomotor function, and contribute to long-term improvements in health, function and participation through increased community mobility.

Eligibility criteria:
inclusion criteria: * history unilateral stroke \> 6 months duration * walks without physical assistance at speeds \< 1.0 m/s exclusion criteria: * no other cardiopulmonary, metabolic, neurological orthopedic injury that may contribute to walking outcomes

Keywords: locomotion
randomised controlled trial on using active warming to prevent newborn hypothermia after caesarean delivery

Conditions: Newborn; Hyperthermia

Summary: despite the enormous advantages that skin-to-skin contact (stsc) and delaying cord clamping (dcc) bring, newborns can lose heat quickly if they are not thermally protected. in the first 10-20 minutes after birth, newborns can experience a body temperature drop of between 2°c to 4°c if they are not properly dried and covered. in 2014, horn et al. published a research paper regarding the incidence and prevention of newborn hypothermia after caesarean delivery. the findings showed up to 80% of newborns become hypothermic if only warm towels (passive insulation) were used during stsc after caesarean delivery. evidence also shows higher hypothermia rates in infants born by caesarean section than vaginal birth. stsc will begin while caesarean section continues. newborns will be clothed in a cotton hat and diaper. newborns will be placed on bare chest of mother, horizontally, in prone position. the head of the newborn will turn laterally, making the nose and mouth unobstructed. newborns' hands are not swaddled and are free to move to allow exploration to facilitate first feeding. in both groups, infants will be covered from head-to-toe with 3 layers of 100% cotton woven blankets, taken from a 70°c heating cabinet. for the "intervention group", thermal blanket will be placed on top of the cotton blanket. newborn will be first covered with conventional warm blanket then adding the thermal blanket on top. the thermal blanket will be placed inside a "pillowcase" like cotton blanket to avoid direct contact with mother or newborn.


Eligibility criteria:
inclusion criteria: * all women scheduled for elective caesarean section under spinal anaesthesia during study period. exclusion criteria: * multiple pregnancy * gestation \ 42 week * placenta previa or abruptio placenta * abnormal cardiotocogram or fetal heart rate immediately prior to caesarean section * suspected or known fetal congenital abnormality * immediate newborn condition that prevents stsc * newborn birth weight \<2.5kg * newborn rectal temperature \>38°c * maternal tympanic temperature \>38°c
endometrial polypectomy performed with bipolar electrode versapoint vs microscissors or graspers

Conditions: Endometrial Polyps

Summary: hysteroscopy today is considered the gold standard for the diagnosis and treatment of endometrial polyps. several hysteroscopic systems to resect endometrial polyps are currently available. among others bipolar systems and microscissors or graspers, both of theme make part of routine clinical practice and are universally accepted. the aim of the study is to compare the efficacy of bipolar resection energy polypectomy versus microscissors or graspers these procedures assume a lower cost and are associated with a lower surgical risk due to their realization without anesthesia . hypothesis: resection of polyps outpatient laser diode has a similar or superior to that of the bipolar electrode tolerability. the diode laser is a viable , quick , simple technique with a high percentage of resection and high degree of satisfaction of patients


Eligibility criteria:
inclusion criteria: * the patient must be informed about the study, and sign the informed consent exclusion criteria: * positive pap smear test * pregnancy * uterine malignancy * abnormal uterine bleeding
scar outcomes for scalpel versus diathermy neck incisions in an afro-caribbean population

Conditions: Surgical Incision

Summary: this is randomized controlled double-blinded trial comparing the scar outcomes of diathermy versus scalpel surgical incisions in the neck. it was conducted in humans in an afro-caribbean (black) population.

this double-blinded parallel group randomized controlled trial included consecutive eligible ear, nose and throat (ent) patients at a jamaican tertiary hospital requiring an anterior neck incision. the purpose was to determine whether cutting diathermy adversely affected scar cosmesis in an afro-caribbean population and whether complexion influenced this outcome. half of the incision in each of 35 patients was randomly assigned to either cutting electrocautery or scalpel. the patients and the assessor of the scars were blinded and the both sides of the scar were assessed by both parties using the patient component of the patient and observer scar assessment score (psas) and the vancouver scar scale (vss) at 1 week, 3 months and 6 months postoperative intervals. the fitzpatrick phototyping scale was used for skin pigmentation classification.

Eligibility criteria:
inclusion criteria: * the following are the conditions for inclusion in the study: 1. subjects must be 18 years of age or older and give written informed consent 2. treatment for surgical condition requires the type of neck incision that would be used for a standard thyroidectomy i.e. a horizontal incision about 2 fingers' breadth above the sternal notch or in a skin crease close to that landmark extending from the anterior border of one sternocleidomastoid muscle to another. 3. only elective surgical cases will be included 4. only primary incisions will be included i.e. no completion thyroidectomies or scar revisions to the neck 5. only clean surgeries will be included 6. all wounds must be closed primarily i.e. no wounds healed by secondary intention or delayed primary closure or flap or graft coverage will be included exclusion criteria: * the following are conditions for exclusion from the study: 1. subjects with skin pathologies i.e. patients with dermatological conditions, skin infections, altered pigmentation to the neck, use of skin-lightening agents to the neck, or neurofibromatosis will be excluded. 2. surgeries requiring a drain (this is a relative exclusion criterion as subjects with drains that are pulled through skin outside of the incision site may be included. however, patient must consent to this prior).

Keywords: skin wound afro-caribbean or black skin diathermy or electrosurgical unit neck surgery scalpel wound
cognitive training and brain stimulation in women with post-chemotherapy cognitive impairment

Conditions: Breast Cancer; Cognitive Impairment

Summary: the aim of this study is to investigate whether a high definition tdcs-accompanied intensive cognitive training of working memory leads to performance improvement in women with post-chemotherapy cognitive impairment after breast cancer treatment.

patients who have undergone chemotherapy, may develop post-chemotherapy cognitive impairment (pcci), which may occur in several cognitive domains and persist for many years. these declines in cognitive functions can lead to psychological distress and affect overall patients' quality of life. the goal of the present study is to assess behavioral effects of a multi-session cognitive training combined with high-definition transcranial direct current stimulation (tdcs) in women with pcci. first studies have shown positive effects of cognitive training on trained and untrained functions and the subjective perception of stress, however the effects are small and transfer effects are inconsistent. a promising approach to elongate and increase the effects of cognitive training is to combine the training with tdcs. therefore, in this study women with pcci will participate in a three-week cognitive training with concurrent online high-definition tdcs application. cognitive performance (primary), as well as quality of life scores and sleep data will be examined before, during and after the intervention. in order to draw conclusions about the effect of tdcs in addition to cognitive training, a control group, receiving sham stimulation during training, will be assessed. a follow-up session to assess long-term effects is planned four weeks after the post assessment. the results of the study will offer valuable insights into efficacy of combined tdcs and cognitive training intervention in women with pcci in order to establish its potential to induce improvements in cognitive functions, and to beneficially affect patient-reported outcome measures.

Eligibility criteria:
inclusion criteria: 1. chemotherapy to treat breast cancer (≥ 6 months post-treatment). 2. self-reported concerns regarding cognitive functioning. 3. age: 18-65 years. 4. right-handedness exclusion criteria: 1. history of dementia before treatment of cancer. 2. other neurodegenerative neurological disorders; epilepsy or history of seizures. 3. severe and untreated medical conditions that preclude participation in the training, as determined by responsible physician. 4. history of moderate to severe substance use disorder according to dsm-5 5. moderate to severe acute psychiatric disorders according to dsm-5 6. contraindication to tdcs application (antal et al., 2017)