Kornimate/medical-research-clean huggingface dataset:
botulinum toxin injection for treatment of vaginismus

Conditions: Vaginismus

Summary: according to high rate of vaginismus (about 10 percent) which leads to unconsummated marriage (about 1 percent) and low efficacy for conventional treatments such as biofeedback therapy, analgesic drugs and pain killers and surgical treatment, there's necessity to find more effective method. in our previous study, injecting botulinum toxin in 23 patients cured 75% of them.now we are to make comparison between different doses of toxin injection and record the patient sexual satisfaction.

vaginismus is the recurrent or persistent involuntary contraction of the perineal muscles surrounding the outer third of the vagina when penile, finger, tampon, or speculum penetration is attempted . vaginismus can be primary, in which the women has never been able to have intercourse, or secondary, which is often due to acquired dyspareunia. it is relatively rare, affecting about 1% of women . treatment of vaginismus is directed toward extinguishing the conditioned involuntary vaginal spasm. this can be accomplished by teaching kegel exercises to acquaint the patient with voluntary control of her levator muscles. medications such as lubricants, anesthetic creams, propranolol, or alprazolam to reduce anxiety have been used effectively, but approximately 10% of patients do not respond. botulinum toxin type a has been successfully used to treat a wide range of muscular disorders such as strabismus, blepharospasm, and cervical dystonia. it is also been used to reduce facial lines and wrinkles.the extent of paralysis depends on the amount of toxin to which there is exposure relative to muscle bulk.in our previous study, one week after injecting botulinum toxin in 23 patients (95.8%) had a vaginal exam, which showed no or little resistance; 18 (75%) achieved satisfactory intercourse after the first injection. now we are to make comparison between different doses of toxin injection and record the patient sexual satisfaction.

Eligibility criteria:
inclusion criteria: * unconsummated marriage * difficult mating * no response to biofeedback exclusion criteria: * patient unlikely to have toxin injection * not having mutual life with partner * non treated pelvic and vaginal infection

Keywords: vaginismus botulinum toxin a dyspareunia unconsummated marriage
pharmacokinetic properties of nalmefene in subjects with renal impairment and in healthy subjects

Conditions: Renal Impairment

Summary: to investigate if renal impairment will have an impact on the pharmacokinetics of nalmefene


Eligibility criteria:
inclusion criteria: * healthy young subjects and subjects with renal impairment with a glomerular filtration rate (gfr) of 50-80 ml/min/1.73m2, 30-\<50 ml/min/1.73m2, \<30 ml/min/1.73m2 will be included in the study. * the subjects must have a bmi between 19 and 32 kg/m2. exclusion criteria: * the subject has a history of renal transplant or is undergoing dialyse treatment. * the subject is, in the opinion of the investigator, unlikely to comply with the protocol or is unsuitable for any reason. other inclusion and exclusion criteria may apply.
psychological impact of covid-19 assiut university hospital experience

Conditions: Psychological Impact of Covid-19

Summary: psychological impact of covid-19 in assiut university hospital

coronavirus disease 2019 (covid-19) is a new communicable disease caused by the new strains of severe acute respiratory syndrome coronavirus, sars-cov-2 . the first outbreak reported was in december2019, in wuhan, china, as pneumonia of unknown etiology linked to a seafood market exposure covid-19 affects different people in different ways. most infected people will develop mild to moderate illness and recover without hospitalization. the evolution of the novel corona virus disease (covid-19) and its expeditious dissemination have led the world health organization (who) to declare it a pandemic on 11 march 2020 . as of 16 may 2020, there have been 4,425,485 confirmed covid-19 cases and 302,059 related deaths worldwide and egypt has been among the most affected countries in the eastern mediterranean region with 11,228 confirmed cases and 592 deaths . as a consequence, many countries, including egypt, have set a state of lockdown to hinder the spread of infection among people resulting in a global atmosphere of depression and anxiety associated with social isolation, fears of getting infected, breaks in the supply chains, financial distress, disrupted travel plans, and future uncertainty . several epidemiological studies from china detected a high prevalence of psychological disturbances among the public during the covid-19 pandemic. for example, a large online survey of 56,679 individuals from 34 provinces in china reported numerous psychological conditions during the covid-19 pandemic: depression (27.9%), anxiety (31.6%), stress (24.4%), and insomnia (29.2%) . also, a study conducted on 4872 chinese people from 31 provinces showed a high prevalence of depression (48.3%) and anxiety (22.6%) related to the covid-19 pandemic . a similar study revealed depression (20.1%), anxiety (35.1%), and poor sleeping (18.2%) among 7236 chinese people . another study conducted on 7143 college students in china detected anxiety among 25% of them . in low- and middle-income countries, such as egypt, where infection control precautions, surveillance programs, laboratory capacity, and public health resources are limited , the response to the covid-19 pandemic is challenging and, as a result, the psychological impacts of the pandemic on the public can be even worse. thus, we conducted this study to evaluate several forms of psychological disturbances .

Eligibility criteria:
inclusion criteria: * age more than 18 years old * diagnosed as covid-19 by positive pcr * comes to assiut university hospital * both sex males and females exclusion criteria: * age less than 18 years old * past history of psychatric disorder
monitoring obese patients : impact on the frequency of monitoring weight

Conditions: Obesity; Morbid Obesity; Quality of Life

Summary: the literature data show that long-term monitoring has an effect on weight loss, comorbidity and on improving the quality of life. however, there are still no studies on monitoring obese patients after taking initial multidisciplinary approach. the recommendations of the has 2011 advocated "continuous monitoring needed to prevent weight regain, monitor the consequences of overweight and treat comorbidities. this requires a long-term support. "the frequency of follow-up consultations is not specified and "must be adapted to achieve a weight loss target and maintain." having no specific recommendations on the frequency of monitoring, the investigators chose to experiment closer monitoring than our current monitoring to assess what is the best frequency monitoring, in terms of: weight loss, quality of life, feeding behavior, changes in physical abilities, evolution of comorbidities associated with obesity. the recommendations of the has 2011 advocate support of a multidisciplinary obesity for weight loss of 5% to 10 %, which, if maintained, can reduce comorbidities associated with obesity (type 2 diabetes, hypertension, pain associated with osteoarthritis).

2 groups of randomized patients will be followed: * the control group will follow the current center: every four months for a year, combined with monitoring by email or regular mail during the year. * the experimental group will be a follow-up every two months for one year hdj more of the same followed by email or postal mail. follow by email or mail is identical to the control group, as well as hdj 12 months.

Eligibility criteria:
inclusion criteria: * - age ≥ 18 - ≤ 75 years * obesity with a bmi ≥ 35 or ≥ 30 if associated with at least one comorbidity whose support was commenced or continued during the initial hospitalization. * patients hospitalized for a period of at least 3 weeks in the bernard descottes center and were supported on dietary, psychological, psychomotor and physical education in a therapeutic approach. * patients who have signed consent form. * patients who never underwent bariatric surgery and bariatric surgery have not seen in the year following their hospitalization in bernard descottes center. * patient accepting the constraints of the protocol in case of close monitoring. * patients able to travel with their own vehicle to bernard descottes center. * affiliate or beneficiary of a social security scheme exclusion criteria: * - patients who have hospitalized in bernard descottes center. * failure to follow the protocol because of insufficient command of french or concomitant illness. * pregnant or breastfeeding. * patients under guardianship or under judicial protection. * participation to another trial which can impact on patient's experimental disease during all the study, and patients who are in an exclusion period of another trial.

Keywords: obesity morbid obesity therapeutic education
a family-based intervention for drug-abusing adults in hong kong

Conditions: Drug Abuse

Summary: to develop a family-based intervention with components of engagement, family roles, affection, and competence and verify its effectiveness on drug abstinence and family functioning for drug-abusing adults in hong kong; to compare the difference between family-based intervention and routine care which mainly consists of individual counselling services for drug abusers.

this is a quasi-experimental trial examining the effects of a proposed family-based intervention for drug abusers on motivating them to stay drug abstinence and improve family functioning, in which 40 drug abusers with focal families (including spouses and/or children) will be recruited for intervention group receiving both family-based intervention and routine care and 40 drug abusers without involving family will be recruited for comparison group receiving routine care. in the in-take, drug-abusing subjects will be given a brief introduction and invited to provide basic background information about themselves and families. after filling the informed consent, participants will be assigned to intervention group or comparison group according to whether their family will join sessions together. after drug abusers and families fill in the online questionnaire at the baseline (t0), the intervention group will receive family-based intervention and routine care in one month, while the comparison group will receive only routine care in one month. both groups will be assessed at two time points after intervention period (t1 = 1-month after baseline; t2 = 2-month after baseline). as hypothesized, the intervention group will show a greater reduction in the primary outcomes of drug use and greater increase in the secondary outcomes of family functioning than the comparison group. a repeated-measures analysis of covariance will be conducted to assess the effects of family-based intervention.

Eligibility criteria:
inclusion criteria for intervention group: 1. adults aged 18 to 55 2. have used drugs in the past 90 days 3. at the time of case recruitment, the subject is engaged in an intimate relationship with a spouse/partner, or having a child/children 4. understand oral and written chinese exclusion criteria for intervention group: 1. taking other treatments during intervention 2. the spouse or child of da are not available to participate in the program inclusion criteria for comparison group: 1. adults aged 18 to 55 2. have used drugs in the past 90 days 3. understand oral and written chinese exclusion criteria for comparison group: 1. taking other treatments during intervention

Keywords: drug abuse
the incidence of gallstones after gastrectomy

Conditions: Gallstone; Gastric Cancer

Summary: to provide preventive and therapeutic strategies for participants with gallstones after gastric cancer by comparing the risk of postoperative gallbladder stone formation with two different resection ranges using the roux-en-y reconstruction modality in radical gastric cancer surgery.

a large number of clinical studies have found that the incidence of gallstones in patients after radical gastric cancer surgery is higher than that in the normal population. however, the pathogenesis has not been clarified, and the prophylactic removal of the gallbladder in patients with gastric cancer remains controversial. a previous study found a statistically significant incidence of gallbladder stones after billroth i versus roux-en-y in distal gastrectomy for gastric cancer. therefore, the investigators plan to conduct a retrospected cohort study to collect further participants with gastric cancer who underwent total gastrectomy to answer whether different surgical resection ranges during surgery increase the incidence of gallstones this question.

Eligibility criteria:
inclusion criteria: * patients with gastric cancer underwent gastrectomy exclusion criteria: * age less than 18 years or age greater than 75 years; * not roux-en-y reconstruction; * r0 excision is not achieved; * previous history of upper abdominal surgery, such as cholecystectomy, gastrectomy; * preoperative gallbladder diseases, such as gallstones, gallbladder polyps, chronic cholecystitis; * preoperative neoadjuvant chemotherapy or radiotherapy; * previous history of malignant tumours; * patients with mental or developmental abnormalities or women during pregnancy or breastfeeding; * gastric perforation or bleeding leading to emergency surgery; * palliative surgical treatment; * incomplete case information.

Keywords: gallstone gastric cancer gastrectomy
safety and tolerability of gx-g6 in healthy male subjects

Conditions: Diabetes Mellitus

Summary: this study is a single-center, double-blind, placebo-controlled, phase i study with healthy male subjects receiving ascending single s.c. doses of gx-g6

a screening examination will be performed within 28 days prior to dosing. eligible subjects will return to the study center in the morning of day -1 and will remain in-patient until discharge about 98 hours after dosing (after oral glucose tolerance test in the morning of day 5) if there are no safety issues. the s.c. injection will be administered in the morning of day 1. ambulatory visits will take place on days 7, 9 and 12. a follow-up visit will take place on day 15 and a final visit on day 28.

Eligibility criteria:
inclusion criteria: 1. male subjects aged between 18-50 years (both inclusive) 2. healthy subjects as determined by medical history, physical examination including vital signs, ecg and clinical laboratory testing 3. subjects who are able and willing to give written informed consent 4. male subjects must be using 2 acceptable methods for contraception (one of these methods should be a barrier method e.g. spermicide and condom) from start of dosing and refrain from fathering a child in the 3 months following dosing. exclusion criteria: history of: 1. clinically relevant allergy (except for untreated, asymptomatic, seasonal allergies at time of dosing), especially allergy to macrolide antibiotics; 2. any clinically significant pancreatic, hepatic, renal, gastrointestinal, cardiovascular, respiratory, hematological, central nervous system diseases or other significant diseases which might influence either the safety of the subject or the absorption, metabolism or excretion of the active agent under investigation; 3. diabetes mellitus and thyroid dysfunction or other endocrine disorders; 4. malignancy; 5. substance abuse or addiction (alcohol, drugs) in the past 3 years. present condition: 6. participation in a clinical investigation within the 30 days prior to the planned first drug administration or during this trial; 7. participation in this study at a previous dose level;
the immediate effects of applying dynamic tape, kinesio tape and sport tape with chronic ankle instability

Conditions: Taping; Ankle Sprains

Summary: injuries to the ankle joint account for 20% of the population that is afﬂicted with joint injury and the largest percentage of self-reported musculoskeletal injuries (\> 10%) are to the ankle. ankle sprain has a large portion in ankle injuries and occurs not only in the sporting population but also in the general community. although the acute symptom would be resolve quickly, but many people still report persisting problems, such as pain and instability. chronic ankle instability (cai) is one of the most common of these residual problems. kinesio tape and white duck tape are often applied in patients with cai, attempt to increase the ankle joint stability, and improve motor performance. however, the previous studies had controversial result to the effects of kinesio tape and white duck tape. the previous studies also showed the insufficient of supporting force and elasticity of kinesio tape and white duct tape. the dynamic tape was developed by kendrick in 2009, which refined the characteristic of elasticity and supporting force. therefore the purpose of study is to comparison the effects of static and dynamic balance performance, weight shifting ability and functional movement between kinesio tape, white duck tape and dynamic tape when applied on patients with cai. with the result may provide an optical method to increase the movement performance of patients with cai. the study suspected to recruit 90 volunteers with cai, and randomly divided to three different groups: kinesio tape group, white duck tape group and dynamic tape group. we make postural stability test and limit postural stability test with biodex balance system (sd), y-balance test and single leg hop test to both affected side and sound side foot before applying the tape. after applying the tape according to the divided group, we will repeat the test above again. we will compare the results of the test between groups and within groups.


Eligibility criteria:
inclusion criteria: 1. a history of at least one signiﬁcant ankle sprain * the initial sprain must have occurred at least 12 months prior to the study enrolment * was associated with inﬂammatory symptoms (pain, swelling, etc) * created at least one interrupted day of desired physical activity 2. a history of the previously injured ankle joint 'giving way' , and /or recurrent sprain and/or 'feelings of instability'. exclusion criteria: 1. a history of previous surgeries to the musculoskeletal structures (ie, bones, joint structures and nerves) in either lower extremity. 2. a history of a fracture in either lower extremity requiring realignment. 3. acute injury to the musculoskeletal structures of other joints of the lower extremity in the previous 1 months, which impacted joint integrity and function (ie, sprains, fractures) resulting in at least 1 interrupted day of desired physical activity.

Keywords: dynamictape sport tape kinesio tape
a pilot clinical trial with tocotrienol on breast cancer

Conditions: Breast Cancer

Summary: tocotrienol rich fraction (trf) in combination with tamoxifen will improve breast cancer specific survival and recurrence free survival, in women with early breast cancer and estrogen receptor positive tumors.

we conducted a, double-blinded, placebo controlled trial of trf plus tamoxifen versus placebo plus tamoxifen in women with primary breast cancer for five years. both the trf and placebo drugs were prepared and supplied by hovid sdn bhd, malaysia. hovid sdn. bhd. absolutely did not have any influence in the trial designing, patient recruitment, data collection, analysis and reporting. the placebo drug which contained soy oil without tocotrienols had similar appearance and taste as the trf drug. a total of 240 women breast cancer patients were assigned to two groups by minimization method that balanced treatment groups. the intervention group was given trf plus tamoxifen, (n = 120) while control group was given placebo plus tamoxifen, (n = 120). the primary end point was breast cancer specific survival, defined as the time from minimization to death due to breast cancer. the secondary end points included disease free survival, biochemical parameters, liver function and plasma levels of vitamin e.

Eligibility criteria:
inclusion criteria: 1. women with estrogen receptor positive tumors. 2. 40-60 years of age at the start of the tamoxifen therapy. 3. histologically confirmed primary breast cancer. 4. a tumor that was positive for estrogen receptors, progesterone receptors, or both. 5. an eastern cooperative oncology group performance status of 0,1, or 2 (scored on a scale of 0 to 5, with lower scores indicating better function). exclusion criteria: 1. concurrent use of investigational drugs and estrogen receptor status negative or unknown.

Keywords: breast cancer tocotrienol-rich fraction with tamoxifen
trajectory of frailty and cognitive dysfunction in older adults

Conditions: Frailty; Cognitive Dysfunction; Community-dwelling Older Adults

Summary: to explore the heterogeneity of the development trend of frailty and cognitive function of older adults.

according to the inclusion and exclusion criteria, the older adults will be selected from community health service centers in four districts of beijing. frailty and cognitive function of the older adults will be assessed for a 24-month longitudinal multi-time (baseline, 6, 12 and 24 months). the heterogeneity of the development trend of frailty and cognitive function will be explored, and the subgroups of joint development trajectory of frailty and cognitive impairment will be classified, so as to identify high-risk populations that need to be managed.

Eligibility criteria:
inclusion criteria: * age ≥60 years. * older adults with clear consciousness, ability of simple written and verbal communication. * they volunteered to participate in this study, and signed an informed consent. exclusion criteria: * a clear diagnosis of any type of dementia. * there are neurological diseases that clearly lead to cognitive dysfunction, such as severe cerebrovascular disease, brain trauma, intracranial tumors, etc. * they have been clearly diagnosed with mental disorders affecting cognitive function, including schizophrenia, depression, bipolar disorder, etc.