Kornimate/medical-research-clean huggingface dataset:
responsiveness of outcome scales in breast cancer related lymphedema

Conditions: Lymphedema of Upper Arm

Summary: the aim of this study is to investigate and compare responsiveness of current lymphedema assessment scales validated in turkish.

lymphedema is defined as the excessive and persistent accumulation of fluid, extracellular proteins, and fat in tissue spaces, caused by inefficiency of the lymphatic drainage system. it is a chronic, progressive condition. several researchers have investigated the influence on health-related quality of life in upper limb lymphedema after breast cancer treatment using patient reported outcome instruments. responsiveness of only one of the lymphedema assessment scale, ''lymphedema quality of life inventory'', has been investigated. responsiveness of lymphedema assessment scales validated in turkish has not been examined in detail, thereby limiting their use in clinical trials. therefore, the aim of this study is to investigate and compare responsiveness of current lymphedema assessment scales validated in turkish. patients with breast cancer related lymphedema with international society of lymphology-isl lymphedema stage 2,3 will be included in the study and will receive complex decongestive therapy phase i including meticulous skin and nail care, manuel lymphatic drainage, compression bandages, and remedial exercises. all patients will receive manual lymphatic drainage for three times a week (monday-wednesday-friday) during 4 weeks, 50 minutes a day (a total of 12 sessions) by a trained lymphatic massage therapist. limb volume will be calculated based on truncated cone method from circumference measurements. patients will complete lymphedema life impact scale (llis), patient benefit index-lymphedema(pbi), lymphedema functioning, disability and health questionnaire(lymph-icf), european organization for research and treatment of cancer quality of life breast cancer (eortc-qlq-30) and short form 36 (sf-36) before and after treatment. changes in limb volumes will be compared in changes in scales after treatment. responsiveness of the subscales will be will be determined by calculating the effect size (change in all patients), standardized mean response (effect size in a group with improvement), and guyatt's responsiveness index.

Eligibility criteria:
inclusion criteria: -patients with unilateral postmastectomy lymphedema with a international society of lymphology-isl) stage 2 and 3 exclusion criteria: * bilateral lymphedema * the patients who had known systemic edematogenic conditions (e.g., cardiac/hepatic/renal failure, terminal cancer, on chemotherapy), and/or with cancer recurrence * patients with contraindications for application of complex decongestive therapy (active cutaneous infection, deep vein thrombosis, cardiac edema, and peripheral artery disease)

Keywords: breast cancer related lymphedema lymphedema outcome measurement responsiveness
magnetic resonance venography pre- and post-treatment in patients with idiopathic intracranial hypertension

Conditions: Pseudotumor Cerebri

Summary: this prospective study will use magnetic resonance imaging of patients with idiopathic intracranial hypertension (iih), to determine if the common radiological finding of transverse venous sinus stenosis can be reversed with standard of care medical treatment of iih.

patients with suspected idiopathic intracranial hypertension (iih) will be recruited and undergo an ophthalmologic investigation, and a lumbar puncture, both of which are necessary for diagnosis of iih. mri is done as a standard of care to rule out other etiologies of raised intracranial pressure. our patients will require four mri/mrvs. the first mri/mrv is standard of care scan. the second mri/mrv will be on the day of the lumber puncture, immediately following the procedure. the third mri/mrv will take place when significant reduction of clinical papilledema has taken place (about 3-6 months), and a forth mri will take place one year after the initial presentation or with symptom resolution, whichever comes first. radiological findings will be compared at all stages to determine if transverse venous sinus stenosis can be reversed with standard of care medical treatment.

Eligibility criteria:
inclusion criteria: all patients with a diagnosis of iih, where other intracranial pathology has been ruled out, can participate. exclusion criteria: (1)patients who have a contraindication or are unable to undergo magnetic resonance imaging. (2)patients who are found to have intracranial pathology to explain elevated intracranial pressure. (3)patients with allergies to gadolinium-containing agents.(4)patients with elevated creatinine above normal laboratory values.
comparison of two needle aspiration techniques for endoscopic ultrasound-guided fine needle aspiration (eus-fna) in solid pancreatic lesions

Conditions: Pancreatic Solid Lesions; Pancreatic Mass

Summary: the aim of this study is to compare endoscopic ultrasound and fine needle aspirate with a standard 22-gauge needle using either "standard-suction" or "capillary suction" methods for solid pancreatic lesions. investigators hope to discover the best technique for obtaining diagnostic material when patients with a pancreatic mass undergo endoscopic ultrasound and fine needle aspirate procedure. there are currently several techniques for obtaining tissue during endoscopic ultrasound and fine needle aspirate. the procedure will be performed by either the capillary suction technique or no suction technique.


Eligibility criteria:
inclusion criteria: - in-patients and out-patients between the age of 18years and 90 years with pancreatic masses presenting for eus-fna exclusion criteria: * uncorrectable coagulopathy (inr \> 1.5) * uncorrectable thrombocytopenia (platelet \< 50,000) * uncooperative patients * pregnant women (women of childbearing age will undergo urine pregnancy testing, which is routine for all endoscopic procedures) * refusal to consent form * cystic lesions * inaccessible lesions to eus

Keywords: pancreatic solid lesions pancreatic mass pancreatic cancer endoscopic ultrasound eus fine needle aspiration fna eus-fna
modified environment for agitation in patients with tbi

Conditions: Traumatic Brain Injury (TBI); Agitated Behaviour

Summary: this study examines the effect of an intervention consisting of dynamic circadian light and sound therapy, as well as systematic information on sleep pattern, agitated behavior and functioning level.


Eligibility criteria:
inclusion criteria: * patients with moderate and severe traumatic brain injury (tbi) * diagnosed with glasgow coma score (gcs) lower than 13- exclusion criteria: * patients with psychiatric diagnose and not speaking danish -
selective manual therapy techniques in chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: our study aiming for determining the combined effect of selective manual therapy techniques in chronic obstructive pulmonary disease patients

i will apply selective manual therapy techniques in form of mobilization techniques ,myofascial release techniques combined with traditional treatment to determine thier effect in chronic obstructive pulmonary disease patients

Eligibility criteria:
inclusion criteria: * all patients must diagnosed mild to moderate chronic obstructive pulmonary disease * all patients should have foreward head and kyphosis exclusion criteria: * history of osteoporosis. * acute exacerbation. * presence of active hemoptysis * presence of malignant disease
endoscopic nasopharyngectomy for newly diagnosed stage i nasopharyngeal carcinoma patients

Conditions: Nasopharyngeal Carcinoma; Endoscopic Surgery; Primary Napharyngeal Carcinama; Stage I Nasopharyngeal Cancer

Summary: nasopharyngeal carcinoma (npc) is most prevalent in eastern asia, with the highest incidence reported among the cantonese population from the province of guangdong. radiotherapy is the cornerstone of initial treatment due to the radiosensitive behavior of npc and its deep-seated location. although radiotherapy has achieved satisfactory results, it can also cause some severe adverse events. currently, surgery is only applied to the treatment of recurrent npc (rnpc) patients, mainly dominated by the conventional open surgery. however, the traditional surgery was accompanied by high rate of treatment-induced complications and low rate of block removal, which greatly limited the surgical application to the treatment of primary npc. with the continuous improvement in surgical techniques, especially the electronic endoscopic system to be used in the surgical treatment recently, endoscopic nasopharyngectomy can largely overcome these shortcomings of traditional surgery mentioned above. in addition, the investigators retrospectively analyzed the survival outcomes of 9 patients with npc (all t1n0m0 according to the uicc / ajcc seventh staging) treated with endoscopic nasopharyngectomy in our hospital, with 5-year rate of overall survival, loco-regional-free survival, distant metastasis-free survival of 100%. therefore, the investigators considered endoscopic nasopharyngectomy for staged i npc patients feasible. this study will focus on the survival outcomes and quality of life of the staged i npc patients treated with endoscopic nasopharyngectomy.


Eligibility criteria:
inclusion criteria: * previously untreated, biopsy-proven world health organization (who) types ii or iii npc; stage i disease (american joint committee on cancer 7th edition); between 18 and 70 years old; adequate bone marrow, liver and renal function; satisfactory performance status: a score of 0 or 1 using the eastern cooperative oncology group system; patients provided signed informed consent. exclusion criteria: * evidence of relapse or distant metastasis; history of prior malignancy or previous treatment for npc; the presence of uncontrolled life-threatening diseases; the investigator considered the patient unable to complete the study.
cd36 and human fat taste perception

Conditions: Obesity

Summary: the purpose of this study is to determine the effect of common human variants in in taste related genes, such as cd36 gene, a putative fat taste receptor, affect fat taste perception.

at present, the general agreement is that humans perceive five taste qualities: sweet, sour, bitter, salty and umami (the savory, meaty taste of some amino acids). it is believed that these qualities evolved to help us find nutrients (e.g. sweets, umami signaled calories) and avoid potential harmful substances (e.g. bitter signalized poison). despite the fact that some fats, which can only be obtained through the diet, are essential for life, fat is not considered a basic taste; and, the issue of how fats are precisely sensed is unresolved. however, increasing evidence suggests that, in addition to smell and texture, taste plays an important role in fat perception. putative fat taste receptor classes have been identified in animal models. one such receptor is the glycoprotein cd36, previously documented to be involved in trafficking and storage of fat. cd36 was recently found in rodents' and humans' taste buds. in rodents, cd36 deletion blunts specifically fat recognition. although cd36 variants are frequent in humans, its role in humans' fat taste perception and preferences remains incompletely understood and will be the focus of the current proposal. the main goal of this study is to determine the effect of a common human variant in the cd36 gene on fat taste perception by using standardized sensory evaluation techniques. in addition, we will examine whether common variants in taste related genes (other than cd36) are associated with individual differences in the perception of flavors of milkshakes prepared with different amounts of fats.

Eligibility criteria:
inclusion criteria: * bmi \>18-\ 29.9 kg/m2. * 21 to 50 years of age exclusion criteria: * previous malabsorptive or restrictive gastrointestinal surgery * smoking * pregnancy or breastfeeding * diabetes * taking medication that might affect taste perception

Keywords: taste perception individual differences fat genetics
impact and burden of rugby injuries in argentina. a complete season retrospective multicentric study.

Conditions: Injuries

Summary: the aim of this study was to describe the prevalence, incidence and injury load suffered in male amateur rugby players from argentina during a competitive season in 2019.

introduction: currently, rugby is a sport that is giving priority to the well-being of the player. players are subjected to high training and match loads exposing them to constant stress that can lead to overload injuries in addition to frequent contact injuries. despite knowing what the situation is like at the international and national level, the "unión argentina de rugby" lacks conclusive epidemiological data. our main purpose was to describe the prevalence, incidence and injury load suffered in male amateur rugby players from argentina during a competitive season in 2019. design: observational, descriptive, retrospective and multicenter study. participants: 250 male amateur rugby players belonging to three clubs from three rugby unions (buenos aires, córdoba and rosario) of argentina. methods: registration methods were applied according to the consensus of the world rugby by a single observer per center. injuries occurred in players from top rosters of 3 amateur rugby clubs (data collection centers) as well as the number of matches and hours of training were recorded. medical diagnoses were classified under the rules of the osiics classification system. the incidence (injuries / 1000 hours-game-player), prevalences (point and period), the severity (days of absence) and the injury load will be calculated as well as the location, type, nature. this study followed the guidelines of the strobe-siis initiative declaration.

Eligibility criteria:
inclusion criteria: * \>18 years * participation in more than 80% during training and matches of the competitive season. * first, intermediate, pre-intermediate a and pre-intermediate b categories of the university teams of córdoba, old resian and los matreros, belonging to uar member unions. exclusion criteria: - lost patient data

Keywords: epidemiology incidence injury severity football
evaluation of a residential in-reach program in regional and rural australia

Conditions: Aged; Acute Disease

Summary: residential in-reach (rir) programs are designed to provide responsive care for residents in residential aged care homes (rach) with the aim of avoiding unnecessary hospital transfers. the evidence for their clinical and cost-effectiveness and implementation has been established in urban settings, but there is a small amount of low-quality evidence for rural and regional settings. the grampians region health service partnership resi-in-reach redesign committee will be implementing a new rir program to be offered to all rachs in the grampians region, this project aims to evaluate the clinical and cost-effectiveness of this program, and its implementation in the rural and regional setting. a stepped-wedge trial will be conducted so that as the rir program is gradually rolled-out across the region, outcomes can be compared in the same facilities across time and between different facilities. the primary outcome measure will be presentation to emergency departments and urgent care centres, and data will also be collected on other clinical outcomes and barriers and enablers of implementing the program. it is anticipated that there will be a reduction in hospital presentations, and a range of barriers and enablers unique to the rural and regional setting will emerge.


Eligibility criteria:
inclusion criteria: * health services that have emergency departments and/or emergency care centres that admit residents from residential aged care homes (rach) * rachs that do not currently have access to rir programs * health service staff who have been involved with the set-up and delivery of the rir program, * rach staff who have experience of or accessing the rir service for residents at least once, * residents living at a rach who has experienced receiving medical care from the rir program and can provide informed consent, or a family member of the resident, * general practitioners whose case load includes residents from rachs. exclusion criteria: • rachs that already have access to a rir program will be excluded

Keywords: stepped-wedge trial residential aged care home residential in reach hospital avoidance
lymphangiogenesis factors in heart failure states

Conditions: Heart Failure; Heart Failure With Reduced Ejection Fraction; Heart Failure With Normal Ejection Fraction

Summary: heart failure often causes fluid to accumulate in the body, leading to congestion and swelling. however, some people who have had heart failure for a long time seem to have very little congestion or swelling, even when the heart failure is poorly treated. the investigators think that this is because lymphatic vessels are able to grow and remove fluid to prevent congestion. the investigators do not know how lymphatic vessels grow. this study will investigate the blood levels of various proteins to try to figure out how the lymph vessels of people with long-standing heart failure might grow.


Eligibility criteria:
inclusion criteria: * undergoing clinically indicated right heart catheterization. exclusion criteria: * unable to provide consent. * use of medications which may alter lymphangiogenesis factor expression within 365 days * thalidomide, lenalidomide, pomalidomide * bevacizumab * any cytotoxic chemotherapy agents * pregnant * any potentially pregnant patient (based on age and gender) undergoes beta human chorionic gonadotropin testing as standard of care prior to any right heart catheterization. * active cancer within 365 days * diagnosis of familial or secondary lymphedema * treatment of active bacterial infection within 7 days * active inflammatory rheumatologic disease requiring anti-inflammatory therapy administration within 60 days * conditions * systemic lupus erythematosus * rheumatoid arthritis * scleroderma * inflammatory myositis * vasculitis * behcet's disease

Keywords: lymphangiogenesis heart failure
low dose vasopressin vs phenylephrine in cardiac surgery

Conditions: Acute Kidney Injury

Summary: this is a randomized, open label study to investigate vasopressin versus phenylephrine as a first line pressor in cardiac surgery. all patients \>18 years of age presenting for coronary artery bypass graft (cabg), valve surgery, or combined cabg and valve surgery will be screened for inclusion. patients with ejection fraction \ moderate pulmonary hypertension, \> mild right ventricular dysfunction, a planned radial arterial graft, or circulatory arrest will be excluded. patients will be randomized to receive either vasopressin or phenylephrine as the first line vasopressor during the perioperative period to maintain mean arterial blood pressure \>65 mmhg. primary outcome is acute kidney injury. secondary outcomes are 30-day mortality, stroke, myocardial infarction, re-operation, sternal infection, atrial fibrillation, intensive care unit length of stay, and total vasopressor hours.


Eligibility criteria:
inclusion criteria: * \>18 years of age * coronary artery bypass graft (cabg), valve, or combined cabg and valve surgery exclusion criteria: * ejection fraction \< 35% * \> moderate pulmonary hypertension * \> mild right ventricular dysfunction * radial arterial graft * circulatory arrest
safety and immunogenicity of vi-crm197 vaccine against s. typhi in children, older infants and infants

Conditions: Typhoid Fever

Summary: this phase 2 trial is aimed to obtain information on the safety and immunogenicity of the vi-crm197 in children and infants from various age groups in the philippines where typhoid fever is highly endemic and an efficacious vaccine against this disease is very much needed.


Eligibility criteria:
inclusion criteria: * subjects belonging to 3 age groups will be enrolled into the trial: children (24 to 59 months of age at enrollment), older infants (9 to 12 months of age at enrollment) and infants (6 weeks of age at enrolment). * written informed consent will be obtained by the parents/ guardians before enrollment into the trial. * infants who have been vaccinated with bcg and hbv at birth and opv at any time since birth can be enrolled into the trial, while infants who have received dtwp+hbv+hib due at 6 weeks of age as per local epi schedule cannot be enrolled into the trial.
functional, dynamic, and anatomic mr urography

Conditions: Hydronephrosis

Summary: this is a clinical feasibility study to assess the value of mr imaging for obtaining functional, dynamic and anatomical information in a comprehensive imaging protocol in subjects having obstructive uropathy.


Eligibility criteria:
inclusion criteria: * males or females 18 years of age or older. * all female patients of childbearing potential must agree to use a medically accepted method of contraception at the time of the study. * patients must have the ability to understand the requirements of the study, provide written and informed consent to participate, and agree to abide by the study requirements. * patients who have known or suspected hydronephrosis or patients with solitary kidneys. exclusion criteria: * patients with known or suspected hypersensitivity to gadolinium-based agents. * patients who are pregnant or lactating. * patients with a condition that is a contraindication to mri (e.g., cardiac pacemaker, epicardial pacemaker leads, cochlear implants, ferromagnetic aneurysm clip, ferromagnetic halo device, or other conditions that would preclude patient proximity to a strong external magnetic field). * patients with a recent history of hemolytic anemia, sickle cell anemia or other hemoglobinopathy. * patients with a history of significant claustrophobia. * patients with impaired renal function based on 24-hr urine collection (creatinine clearance \ 1.8 mg/dl)

Keywords: hydronephrosis
outcomes of adipose derived mesenchymal stem cells on sexual hormone deficiency

Conditions: Hormone Deficiency

Summary: the purpose of this study is to evaluate the safety and effectiveness of adipose derived mesenchymal stem cells (ad-mscs) therapy on sexual hormone deficiency in the middle-aged patients

the purpose of this study is to evaluate the safety and efficiency of adipose-derived mesenchymal stem cells in 30 patients with sexual hormone deficiency at vinmec international hospital, hanoi, vietnam

Eligibility criteria:
inclusion criteria: * age: 35 years to 70 years (male) and from 35 years to menopause age (female) * male: decrease in libido, decrease in intercourse frequency, erectile dysfunction, difficulty in concentration, testosterone level ≤ 12 nmol/dl * female: reduced or absent menstruation after radiation exposure or chemotherapy; hot flushes, excessive sweating, and anxiety, together with other symptoms associated with the menopause, amh level ≤ 2 ng/ml and/or fsh level ≥ 10 miu/ml. * patients signed the informed consent form exclusion criteria: * surgery removal of endocrine glands * abnormalities in the endrocrine glands * hormone deficiency due to diabetes and other metabolic disorders * active autoimmune diseases * current usage of immunosuppressive drugs * coagulation disorders * allergy to anesthetic agents * severe health conditions such as cancer, failure of heart, lung, liver or kidney * active infections

Keywords: ad mesenchymal stem cells;sexual hormone deficiency