Kornimate/medical-research-clean huggingface dataset:
cd19 chimeric antigen receptors and cd19 positive feeder t cells as a leukemia consolidation treatment

Conditions: Acute Lymphoblastic Leukemia in Remission

Summary: this is a single center,randomized ,two-cohorts, open-label ,phase 1/2 study to evaluate the efficacy and safety of t cells expressing cd19 chimeric antigen receptors combined with cd19 positive feeder t cells treatment for cd19+ acute lymphoblastic leukemia patients in remission .

patients were divided into two groups, group 1 and group 2, and each group was enrolled in 5 patients. group 1 patients did not receive any pretreatment, and group 2 patients received pretreatment with cyclophosphamide and fludarabine prior to reinfusion. then patients were given chimeric antigen receptor t-cell( car-t) and cd19-positive t cells.

Eligibility criteria:
inclusion criteria: 1. age 18 to 65 2. voluntary informed consent is given 3. expected survival ≥12 weeks 4. relieve cd19+ acute leukemia 5. organ function: (1)left ventricular ejection fractions≥ 0.6 by echocardiography (2)alt ≤3 times of uln, or bilirubin \ 92% 6. karnofsky score ≥ 60 ; 7. no history of combined chemotherapy in the recent 1 month and no immunotherapy in the recent 3 months; exclusion criteria: 1. uncontrolled active infections 2. active hepatitis b or hepatitis c infection 3. hiv infection 4. history of myocardio infarction in the past 6 months, or history of severe arrhythmia 5. congenital immunodeficiency 6. pregnant or lactating women 7. history or presence of clinically relevant cns pathology such as epilepsy, generalized seizure disorder, paresis, aphasia, stroke, severe brain injuries, dementia, parkinson's disease, cerebellar disease, organic brain syndrome, or psychosis 8. previous treatment with any gene therapy products
mild versus conventional ovarian stimulation treatment for in vitro fertilization

Conditions: Subfertility

Summary: in vitro fertilization (ivf) is an assisted reproductive technique to achieve pregnancy in subfertile couples of which the average success rate is only 25%. mild ovarian stimulation treatment yields less oocytes, has less adverse effects but has a comparable clinical outcome compared to conventional stimulation treatment. there is high inter- and intra person variability in ovarian response and fertility outcome parameters after stimulation treatment and little is known about explanatory variables herefore. nutrition and in particular folate, or its synthetic derivative folic acid, is a b-vitamin which has been widely asssociated with reproductive outcome and subfertility. therefore, in this study we aim to investigate the influence of preconception nutrition and folic acid use on ovarian response after mild/conventional stimulation treatment and to identify biomarkers in the follicular fluid which can indicate oocyte quality and other fertility outcomes.


Eligibility criteria:
inclusion criteria: * all couples with an indication for ivf/icsi treatment in the erasmus medical center exclusion criteria: * prior oocyte donation * endometriosis * hydrosalpinx * mesa/pesa * age \>37 * bmi \ 29kg/m2 * menstrual cycle disruptions * indication for intra cytoplasmic sperm injection (icsi) * prior ivf treatment without embryo transplant * history of recurrent abortion * abnormal karyotype of male/female * uterine abnormalities

Keywords: folic acid homocysteine ovarian response in vitro fertilization
mindfulness meditation versus physical exercise: comparing effects on stress and immunocompetence

Conditions: Stress; Health Knowledge, Attitudes, Practice

Summary: the objective of this research project is to examine if including mindfulness meditation or physical exercise at lunch break improve workers' recovery from work stress. therefore, 72 workers included either mindfulness meditation or physical exercise during their lunchbreaks for a month in order to find out if these recovery strategies have more favorable outcomes than usually spent lunch breaks concerning: a) psychological detachment, b) perceived stress, c) general health, d) burnout, e) fatigue, f) quality of sleep, g) cortisol awakening response and h) immunocompetence.

the investigators conduct an intervention study in a sample of 72 knowledge-workers, who engaged in mindfulness meditation or physical activities for five weeks. they performed from 15 to 30 minutes during their lunch breaks. the investigators randomly assigned participants to three experimental conditions: 1) mindfulness meditation, 2) physical activity, 3) control group (lunch break as usual). online questionnaires before and after intervention assessed long term changes regarding recovery processes, perceived stress, health, mindfulness and burnout. for daily changes, a mobile application was developed to assess changes once per day immediately after work. the investigators also collect saliva samples to map cortisol and immunoglobulin a excretion across the intervention period. the investigators had two follow-up measures one and six months after the intervention.

Eligibility criteria:
inclusion criteria: * knowledge-workers of an specific company with similar stress level. exclusion criteria: * serious illness * regular meditation * regular physical exercise

Keywords: mindfulness physical exercise salivary immunoglobulin a recovery strategy from stress
study of pemetrexed to treat recurrent or progressive primary central nervous system lymphoma

Conditions: Primary Central Nervous System Lymphoma

Summary: the purpose of this study is to determine if pemetrexed is effective in the treatment of primary central nervous system lymphoma (pcnsl) that has either worsened during treatment or has returned after completing treatment.

despite the aggressive upfront use of methotrexate-based chemotherapy, primary central nervous system lymphoma (pcnsl) almost uniformly results in recurrence or progression and death. palliative chemotherapy offers an improvement in time-to-progression, symptom control, quality of life, and potentially, survival. however, no established chemotherapy regimen for recurrence exists and new treatments are needed. pemetrexed is a rationale strategy for therapeutic palliation of recurrent or progressive pcnsl, given its mechanism of action, convenient administration, single agent efficacy, its well established management algorithms, and its evidence of safety and efficacy in systemic malignancies.

Eligibility criteria:
inclusion criteria: * histological confirmation of primary central nervous system lymphoma * male or female \> 18 years of age or older * negative pregnancy test (if of childbearing potential) * any number of previous recurrences will be allowed * karnofsky performance status \> 60 * hematocrit \> 30,000 * platelet \> 100,000 * absolute neutrophil count \> 1,500 * bilirubin \< 1.5 x upper limits of normal * transaminases (alt and ast) \< 1.5 x upper limits of normal * creatinine \< 1.5 x upper limits of normal * creatinine clearance \> 45 ml/min * adequate medical health to participate in this study * adequate documentation of menopause (natural/surgical) or patient commitment to routine use of reliable birth control (barrier/hormonal) * ability to read and understand the patient informed consent form * ability and willingness to follow all requirements of the study including following all directions, taking medication as prescribed, and completion of all diaries and forms exclusion criteria: * karnofsky performance status \< 60 * hematocrit \< 30,000 * platelet \< 100,000 * absolute neutrophil count \< 1,500 * bilirubin \>1.5 x upper limits of normal * transaminases (alt \& ast) \> 1.5 x upper limits of normal * creatinine \> 1.5 x upper limits of normal * creatinine clearance \< 45 ml/min * inability to undergo gadolinium-contrasted mris, including severe claustrophobia or insufficient allergy prophylaxis

Keywords: pcnsl pemetrexed alimta recurrent progressive
adjunctive supplementation of antioxidants (vitamins e + c) plus omega-3 fatty acids

Conditions: Schizophrenia

Summary: this research study helps to demonstrate that adding vitamins and fats (nutritional supplements) to a diet will help reduce body weight and improve the lipid profile. this will be done by examining the body weight and chemicals in the blood. the chemicals are the result of the brain using the fat that subjects eat in their diet. some medications may also change the amount of these chemicals in a person's blood.

to demonstrate that supplementation of antioxidants and omega-3 fatty acids will improve clinical outcome including cognitive performance in olanzapine treated patients.

Eligibility criteria:
inclusion criteria: * age 18 to 55 * va outpatient * diagnosis of schizophrenia by dsm-iv criteria * active treatment with olanzapine * medically healthy exclusion criteria: * diagnosis of mr * mmse score of \< 26 * not on a stable dose of olanzapine

Keywords: weight gain weight gain supplementation antioxidants olanzapine
trajectory analysis of nlr and its association with efficacy of immunochemotherapy in escc.

Conditions: Esophageal Squamous Cell Carcinoma; Immunotherapy; Chemotherapy

Summary: conduct a retrospective and prospective study to confirm the association between blood cells counts and the efficacy and safety in immunochemotherapy in patients with advanced esophageal cancer.

studies have already demonstrated the feasibility of prognostic role of protein biomarkers change during the treatment trajectory of patients in several carcinoma,however, no study focused on the value of trajectory analysis of blood cells counts of immunochemotherapy in patients with advanced esophageal cancer. the investigators plan to analyze the dynamic change of blood cells counts longitudinally from preoperation to long term follow-up in advanced esophageal cancer and predict the efficacy and safety of immunochemotherapy.

Eligibility criteria:
inclusion criteria: * pathologically confirmed esophageal squamous cell carcinoma * potentially resectable esophageal squamous cell carcinoma at first diagnosis (ct1-4a n1-2 m0, ct3-t4a n0m0) * treatment-naive * expected life span \> 6 months * aged 18 - 75 years old * adequate organ functions * performance status (ps) 0-2 * participants are fully informed about the whole study and are willing to sign the informed consent exclusion criteria: * previous history of thoracic surgery or radiation * cervical or multi-origin esophageal cancer * known or suspected experimental drug allergy * pregnant or lactating women * esophagomediastinal fistula * peripheral neuropathy * previous cancer history other than esophageal cancer * severe organ function deterioration that can not tolerate neoadjuvant therapy * previous autoimmune diseases * diabetic history \> 10 years * interstitial pulmonary disease, non-infectious pulmonitis * active type b hepatitis * any other conditions that may affect patients' safety and compliance

Keywords: advanced esophageal carcinoma immunochemotherapy trajectory analysis blood cell counts
comparison of flow controlled ventilation and volume controlled ventilation

Conditions: Vocal Cord Disease; Vocal Cord Cyst

Summary: flow-controlled ventilation is designed to ventilate the patient with constant flows during both inspiration and expiration. during inspiration, the pressure rises linearly from a set positive end-expiratory pressure (peep) to a set positive inspiratory pressure (pip), and then falls linearly from pip to end-expiratory pressure (eep) during expiration. there are no flow interruptions during the flow-controlled ventilation cycle, and the rate of change of pressure and volume in the lungs is equal, allowing for higher tidal volumes at lower pressures. the user sets the inspiratory flow rate and the ratio of inspiratory to expiratory time, providing full control over the ventilation cycle. however, this results in two unusual features: during inspiration, the ventilator creates positive pressure to direct gas into the patient's lungs through the endotracheal tube (ett). when the intratracheal pressure (airway pressure) reaches the set pip value, the ventilator switches from inspiration to expiration. by reversing the flow, it utilizes the bernoulli effect to create negative pressure, facilitating expiration. despite the presence of negative pressure on the ventilator side, the pressure in the patient's airway remains positive at all times. volume-controlled ventilation is a mode that is volume-controlled, time-cycled, time-triggered, and pressure-limited. in volume-controlled ventilation, high pressures are sometimes necessary to reach the target tidal volume. this can lead to barotrauma, atelectrauma, and volutrauma in the lungs. therefore, to avoid high pressures, low tidal volume ventilation is preferred. for microscopic laryngeal surgeries, patients are intubated with a small sized endotracheal tube which results with higher pressures. we think that flow controlled ventilation will improve the ventilation during the surgery with lower pressures.


Eligibility criteria:
inclusion criteria: * patients who undergo elective microscopic laser surgery * asa status i and ii exclusion criteria: * surgery time more than 2 hours * patients with difficult intubation * patients with chronic lung diseases * bmi \> 25

Keywords: microscopic laryngeal surgery flow controlled ventilation volume controlled ventilation
icancope with post-operative pain (icancope postop)

Conditions: Pain, Chronic; Pain, Chronic Post-Surgical

Summary: there are few applications available in the community to help teenagers manage pain after surgery. the focus of this study is to better understand the pain experience of children after having surgery and to design a smartphone app called "icancope with post-operative pain" (icancope postop), to help children and parents to better manage pain at home after surgery. the app will help keep track of pain, provide information about the teenager's surgery and provides "in-the-moment" advice wherever and whenever the patient needs it.

more than 80,000 canadian children undergo surgery each year. despite evidence-based pain management and clinical standards, moderate to severe postoperative pain in children is common. inadequate postoperative pain management contributes to poor health outcomes, increased opioid use, and the development of chronic postsurgical pain. successful postoperative pain management requires regular monitoring and treatment of pain after hospital discharge. smartphones are nearly ubiquitous, and growing evidence supports their use to overcome barriers to pain care. computerized clinical decision support systems (cdss) can improve pain self-management by tracking symptoms over time and offering tailored evidence-informed pain management advice based on standardized algorithms. a comprehensive and sustainable approach is needed to address poorly managed pediatric postoperative pain in the home setting. to address these gaps in care, we are developing "icancope with post-operative pain" (or icancope postop), a smartphone-based cdss app that provides remote, in-the-moment advice to improve pain and health-related quality of life (hrql) for adolescents following surgery.

Eligibility criteria:
inclusion criteria: 1. aged 12 to 18 years; 2. own a smartphone compatible with the icancope app (ios or android); 3. diagnosed with adolescent idiopathic scoliosis or pectus carinatum or pectus excavatum; 4. are able to speak and read english; and 5. scheduled to undergo scoliosis or minimally invasive pectus repair surgery. exclusion criteria: 1. significant cognitive impairment or other co-existing medical condition that could limit the ability to use the icancope app, as identified by their health care provider; 2. participated in a previous study of icancope postop; 3. a diagnosed chronic pain condition not related to the surgical condition; or

Keywords: paediatric chronic pain post-surgical
prevention of cardiovascular events (eg, death from heart or vascular disease, heart attack, or stroke) in patients with prior heart attack using ticagrelor compared to placebo on a background of aspirin

Conditions: Myocardial Infarction; Cardiovascular Death; Atherothrombosis; Stroke

Summary: this study is being carried out to see if a new drug called ticagrelor given twice daily in addition to the asa therapy decreases the frequency of cardiovascular events (e.g., death from heart disease, heart attack, or stroke).


Eligibility criteria:
inclusion criteria: * person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: age ≥ 65 years old, diabetes requiring medication, documented history of 2nd prior mi (\>1 year ago). angiographic evidence of multivessel cad, and / or chronic, non-end stage renal dysfunction. * females of child-bearing potential must have a negative pregnancy test at enrollment * persons who are currently taking aspirin between 75 and 150 mg once daily exclusion criteria: * persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start * persons who have planned coronary, cerebrovascular, or peripheral arterial revascularization (invasive surgery) at study start * persons with known bleeding disorders * persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin * persons with a history of ischemic stroke * persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days. * persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker * persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery * persons with known severe liver disease * persons with kidney failure requiring dialysis * persons with life expectancy \< 1 year

Keywords: heart attack heart disease acute coronary syndrome acs cardiovascular disease
role of patient selection for pancreatic resections

Conditions: Pancreas Disease

Summary: pancreatic surgery is complicated and risky, especially for pancreatic cancer. it's been noticed that having these surgeries done at specialized centers can lead to better outcomes and survival rates. however, factors like patient selection and hospital conditions also play an important role. some studies show that more surgeries done at a hospital might not always mean better results, as the type of patients and procedures can vary. to understand this better, the present study compared outcomes and patient characteristics between high-volume pancreatic centers and others.

the study utilized german nationwide administrative data (diagnosis-related group statistics) spanning from 2010 to 2018. persons who underwent pancreatic resections during this period were included, with exclusions for certain criteria like underage and type of procedure. various factors including patient demographics, diagnoses, procedures, and comorbidities were analyzed to assess in-hospital mortality rates. high-volume pancreatic centers (hvpcs) were identified as those performing at least 50 procedures annually. statistical analyses included comparing crude and adjusted mortality rates and assessing patient characteristics between hvpcs and non-hvpcs. models were adjusted for multiple variables, and methods like the cochran-armitage trend test and mixed models were employed. additionally, the study investigated how differences in patient characteristics between hvpcs and non-hvpcs affected mortality rates.

Eligibility criteria:
inclusion criteria: * partial or total pancreatic resections between 2010 and 2018 exclusion criteria: * childhood (\<18 years) * subjects with a pancreatic transplantation procedure * missing information on age or gender

Keywords: specialization pancreatic surgery resection volume-outcome-relationship
study of the correlation between preoperative precise biometrics, spatial assessment and postoperative visual quality in cataract patients

Conditions: Recruitment of Participants

Summary: this study summarizes the experience of precision treatment and postoperative management of various types of cataract, and intend to further improve the quality of clinical cataract diagnosis and treatment.

based on the existing cataract surgery methods, through prospective follow-up study, this study summarizes the experience of precision treatment and postoperative management of various types of cataract, and intends to further improve the quality of clinical cataract diagnosis and treatment.

Eligibility criteria:
inclusion criteria: * patients with monocular or binocular cataract, lens opacity or abnormal position, need surgery exclusion criteria: * the history of systemic diseases and medication affecting vision, diabetic patients with systemic conditions complicated with retinopathy, uncontrolled blood glucose, severe eye diseases, eye trauma, eye surgery, severe dry eye and ocular surface diseases, strabismus and amblyopia were identified

Keywords: refractive cataract surgery intraocular lens
adherence to lumefantrine-artemether

Conditions: Malaria, Uncomplicated

Summary: this is a study of how well caregivers of children with malaria adhere to the recommended regimen for lumefantrine-artemether (la). children were randomly assigned to either a group receiving directly observed treatment in hospital or to a group treated at home by the routine caregiver (typically, patient's mother). clinical/parasitologic, hematologic, pharmacologic and qualitative parameters were monitored over a 28-day follow-up period and are used to evaluate drug adherence.


Eligibility criteria:
inclusion criteria: * age \< 5 years of age. * axillary temperature \>= 37.5oc * unmixed infection with p. falciparum of between 1,000 and 250,000 asexual parasites/mm3 as determined by microscopic examination of thick, or thick and thin peripheral blood smears. * parent/guardian's informed consent and willingness to participate in the study exclusion criteria: * any evidence of severe or complicated malaria that would require hospitalization for treatment. * reported allergy to any antimalarial drugs, including artemisinin derivatives and sulfa drugs.

Keywords: malaria artemether-lumefantrine co-artem tanzania adherence