Kornimate/medical-research-clean huggingface dataset:
the effect of information and coping with anxiety training given to women before hysterectomy on their level of anxiety

Conditions: Hysterectomy; Anxiety

Summary: purpose: in this study, it was aimed to determine the effect of information and coping with anxiety training given to women before they undergo hysterectomy on their anxiety levels. design and methods: the parallel group post-test randomized controlled experimental design was used in the study. the study sample comprised 59 women.


Eligibility criteria:
inclusion criteria: * agreeing to participate in the study, * being able to speak and understand turkish, * being in the age group of 18-65 years, * being admitted to the aforementioned clinic with a planned hysterectomy surgery, * not having any health problems preventing the person from hearing and speaking, * being conscious, being oriented and cooperated, * not having received any training on hysterectomy before the surgery and during discharge. exclusion criteria: * not agreeing to participate in the study, * not being able to speak and understand turkish, * being under the age group of 18 years, * not being admitted to the aforementioned clinic with a planned hysterectomy surgery, * having any health problems preventing the person from hearing and speaking, * not being conscious, being oriented and cooperated, * having received any training on hysterectomy before the surgery and during discharge.
longitudinal coverage with evidence development study on micra av leadless pacemakers (micra av ced)

Conditions: Bradycardia

Summary: the primary purpose of the study is to meet the cms mandated coverage with evidence development requirement in the national coverage determination for leadless pacemakers as they apply to medtronic micra devices. the study uses administrative claims data of the medicare population implanted with micra av leadless pacemakers or dual-chamber transvenous pacemakers. patients are enrolled through submission of claims or encounter data to cms.

the micra av ced study is a study of the medicare beneficiary population implanted with micra av leadless pacemakers or dual-chamber transvenous pacemakers and will be executed by analyzing administrative claims data. the study consists of two primary objectives: estimate the (1) acute overall complication rate, and (2) the 2-year survival rate of patients implanted with a micra av leadless pacemaker. as part of the secondary objectives of the study, a comparative analysis of micra av leadless pacemakers to dual-chamber transvenous pacemakers will be conducted. the analysis will be in cms claims data and is subject to a central irb. however, individual hospitals are not engaged in research and local irb oversight is not necessary.

Eligibility criteria:
inclusion criteria: * medicare beneficiaries implanted with a micra av leadless pacemaker (cpt 0387t or 33274 or icd-10 pcs 02hk3nz) on or after the study start date will be included in the study. or - medicare beneficiaries implanted with a dual-chamber ventricular transvenous pacemaker \[cpt 33208 or 33213 or 33214 or icd-10 pcs ((0jh606z or 0jh636z) + (02h60jz or 02h63jz or 02h70jz or 02h73jz) + (02hk0jz or 02hk3jz))\] on or after the study start date. exclusion criteria: * none
effects of nature and forest therapy in patients with metabolic syndrome and cardiovascular risk factors

Conditions: Metabolic Syndrome, Protection Against

Summary: the aim of this study is to investigate the effects of regular forest therapy under guidance of a licensed nature therapist on patients with metabolic syndrome and cardiovascular risks

it is assumed that nature and forest experience has sustainable benefits for the physical and mental health of individuals with metabolic syndrome and cardiovascular risk profile. especially co-therapeutic effects in terms of resilience and salutogenesis might effectively and sustainably promoted by nature and forest therapy. the main objective of this study is to measure the effects of nature and forest therapy in subjects with manifest metabolic syndrome and cardiovascular risk factors. the intervention is a stay in the nature of the düppeler forest (berlin-wannsee) under the guidance of trained nature guides (90 minutes, 1x/week over 2 months), who teach exercises on the perception of nature and the connection between nature and health, movement and mindfulness. subjects are also motivated to experience forest nature as regularly as possible (recommended ≥ 30 minutes daily). participants of the control group will be offered a later participation in the therapy program after completion of the last study visit after 4 months (waiting list control group).

Eligibility criteria:
inclusion criteria: * definition of metabolic syndrome according to the international diabetes foundation (idf): * waist circumference: at least 94 cm for men, at least 80 cm for women * plus at least two of the following risk factors: * fasting blood glucose levels of \> 100 mg/dl (\> 5.6 mmol/l) measured in blood plasma or diagnosed diabetes mellitus * elevated triglycerides \> 150 mg/dl (\> 1.7 mmol/l) or therapy already initiated to lower triglycerides * low hdl cholesterol: \< 40 mg/dl (\< 1.05 mmol/l) in men and \< 50 mg/dl (\< 1.25 mmol/l) in women or already initiated therapy to increase hdl * hypertension (from \> 130 mmhg systolic and \> 85 mmhg diastolic) or already treated hypertension exclusion criteria: * serious acute or chronic illnesses * immobility or limitation of mobility due to orthopedic, neurological or other medical cause * participation in another study * serious mental illness * pregnancy and lactation

Keywords: forest therapy forest bathing shinrin yoku metabolic syndrome cardiovascular risks
facefi : cardiac fatigue during intense exercises - pilot study

Conditions: Muscle; Fatigue, Heart

Summary: to attest if a cardiac fatigue appears (and to measure it if it does) during intense physical exercises in two groups of subjects: * canoeists from a training center of the french canoeing team during an intensive session of three weeks of endurance training; * young recruits in military school of officers in ground forces of the french army during an intensive.


Eligibility criteria:
inclusion criteria: * healthy men between 18 and 35 years old; * giving their writing informed consent; * and affiliated to the french social security. exclusion criteria: * to be a smoker. * to present any known pathology that forbids the realisation of any test, or that can alter the measurements: cardiovascular risk factors treated or not (diabetes, dyslipidaemia, arterial hypertension, obesity), cardiac arrhythmia, coronary disease, heart failure, cardiac pacemaker or defibrillator, valvular disease after surgery or not, kidneys failure with dialyse or not, kidney pulmonary cardiac or liver transplantation, chronic bronchopneumopathy, asthma, etc. * to take any medication that could alter autonomic nervous system or cardiovascular adaptation to maximal exercise (anti-arrhythmia, anti-hypertensive, anti-inflammatory,...). * drinking exciting drinks (coffee or tee for example) in the 12h before the tests. * to be under legal protection (trusteeship, guardianship) or to be deprived of liberty.

Keywords: cardiac functions endurance training senior athletes
the efficacy of a psychosomatic intervention

Conditions: Type D Personality; Trauma, Psychological

Summary: this study examines the efficacy of a psychosensory intervention in relation to: resilience, type d personality, and physiological effects (on blood pressure, heart rate and salivary cortisol) in a group of people who have self-referred for the trauma resolution psychosensory therapy - havening techniques (ht).

this study utilizes a single blind (researcher blind) comparison of the psychosensory therapy havening techniques (treatment) versus waiting list (no treatment). participants will be assessed using resilience testing (cd-risc), and type d measure of personality (ds14). a subgroup of the treatment arm will be assessed for the biomarkers of blood pressure, heart rate and cortisol. this parallel-group controlled trial will examine the efficacy of havening techniques at 3 timepoints; baseline (time point 1), twenty-four hours post (time point 2) and one month later (time point 3).

Eligibility criteria:
inclusion criteria: * able to provide informed consent. * cognisant adults living in the united kingdom. * will have self-referred for havening techniques trauma therapy. exclusion criteria: * receiving any other therapeutic or pharmaceutical intervention in parallel. * for the psychobiological evaluation subgroup: a history of hiv, tuberculosis or hepatitis b due to laboratory regulations.

Keywords: psychosensory therapy trauma, psychological ds14 cd-risc resilience psychosomatic medicine type d personality salivary cortisol blood pressure havening techniques
application of polygenic methylation markers in postoperative recurrence monitoring of colorectal cancer

Conditions: Colorectal Cancer

Summary: this study dynamically monitored the prognosis of stage i-iv colorectal cancer patients who could receive radical surgical resection by detecting the levels of polygene methylation in plasma samples from patients with colorectal cancer. in patients with colorectal cancer feasible radical surgery, plasma ctdna methylation detection was performed before and after surgical treatment and during regular follow-up to explore the predictive effect of plasma ctdna methylation status at different time points on postoperative recurrence. to explore whether postoperative dynamic monitoring of plasma ctdna methylation can be used for adjuvant chemotherapy efficacy evaluation and whether it can indicate tumor recurrence and metastasis earlier than imaging examination.

1. patients initially diagnosed with primary colorectal cancer were enrolled for screening, and plasma samples 1-2 days before radical bowel resection were collected for polygene methylation detection. 2. the postoperative follow-up was 2 years, and the reexamination included ct/mri imaging assessment, blood cea, and dynamic monitoring of plasma ctdna methylation level. blood samples were collected for 9 times. 3. results analysis: to explore the application value of ctdna methylation-mrd detection in the prediction of postoperative tumor recurrence risk after radical resection of colorectal cancer; the correlation between preoperative ctdna methylation level and prognosis of early colorectal cancer.

Eligibility criteria:
inclusion criteria: 1. newly diagnosed patients with primary colorectal cancer confirmed by histopathology (no restriction on histological type); 2. patients diagnosed as stage i-iii and feasible for radical bowel surgery; 3. patients diagnosed by stage iv (only colorectal cancer patients with liver metastasis at the time of diagnosis) and feasible radical bowel resection or complete resection of liver metastasis; 4. no gender limitation, age ≥18; 5. ecog score ≤1; 6. life expectancy ≥5 years; 7. those who fully understand the study and voluntarily sign the informed consent. exclusion criteria: 1. blood transfusion was performed during surgery or 2 weeks before surgery; 2. complicated with primary malignant tumors of other organs; 3. with colonic obstruction, intestinal perforation and other symptoms requiring emergency treatment; 4. colorectal cancer was diagnosed with extrahepatic metastasis; 5. neoadjuvant therapy (such as radiotherapy and chemotherapy) before radical bowel resection; 6. radical bowel resection was performed after endoscopic surgery; 7. concomitant symptoms and/or family history collection suggest hereditary colorectal cancer; 8. serious mental illness or drug abuse; 9. patients with serious heart, lung and vascular diseases who cannot tolerate surgery; 10. pregnant or lactating women; 11. participate in other interventional clinical investigators within 3 months 12. poor compliance, unable to complete the study according to the judgment of the researcher.

Keywords: ctdna methylation recurrence monitoring
endothelial dysfunction induced by postprandial lipemia

Conditions: Healthy Subjects

Summary: postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood. therefore we want to study vascular function, as assessed by brachial artery (ba) flow mediated dilation (fmd), in healthy men before and after a high fat meal (hfm) preceded (16-18 hrs) by rest, a single bout of continuous moderate intensity exercise (cme), and high intensity interval exercise (hiie).


Eligibility criteria:
inclusion criteria: * male, 20-40years, bmi between 25 and 30, resident in trondheim. exclusion criteria: * unstable angina, chd, heart failure,

Keywords: flow mediated dilatation maximal oxygen uptake blood lipid
pedal movement - implementing cycling as a mobility option

Conditions: Ileus

Summary: cycling has been a proven exercise for decades as a low impact option to strengthen the lower body and improve cardiovascular health. there is also evidence that cycling helps to stimulate the contraction of the muscles in the intestine. other outcomes frequently examined when considering benefits of ambulation include decreased rates of venous thromboembolic events, pneumonia, and decreased hospital length of stays. therefore, there is added value to consider alternate mobility modalities.

ileus is a common post operative occurrence, one that not only causes patient discomfort but also contributes to considerable economic impact and can potentially progress to other serious complications. historically ileus has been difficult to define. review of the literature produces a general definition to include a varying time frame upon which a patient is not tolerating an oral diet, unable to pass flatus or stool, symptoms of nausea, vomiting, and sometimes abdominal pain. small bowel obstruction, while different pathophysiology than ileus, presents similar manifestations. often ileus and small bowel obstruction follow the same pathway aimed at attempted resolution with attempts at conservative management. efforts to resolve ileus and nonoperative small bowel obstruction include bowel rest, nasogastric decompression, and encouraging mobility. many studies support the practice of mobilization through ambulation as an effort to encourage return of bowel function. what is lacking in review of the literature however are other modalities to offer the patient in efforts to assist and encourage patients to mobilize outside of ambulation.

Eligibility criteria:
inclusion criteria: * admission to northeast acute care surgery * admitted on post surgical care 1 unit * diagnosis of small bowel obstruction * diagnosis of ileus * any patient that has had intestinal surgery * age 18-90 exclusion criteria: * age \< 18 * pregnancy * incarceration * non-english speaking

Keywords: bowel function bowel obstruction cycle therapy mobility
impact of immunosuppression adjustment on covid-19 vaccination response in kidney transplant recipients

Conditions: COVID-19; Immunosuppression; Vaccine Response Impaired

Summary: immunocompromised individuals, such as solid organ transplant (sot) recipients are at high risk of covid-19 associated complications and mortality. retrospective studies so far have shown that a majority of sot recipients did not develop appreciable anti-spike antibody response after a first, second, or even third dose of mrna vaccine. treatment with antimetabolites was associated with poor vaccine response. the goal of this study is 1) examine whether transient immunosuppression reduction improves the immune response to a third dose of sars-cov-2 mrna vaccine in kidney transplant recipients and 2) to assess the safety of immunosuppression reduction before and after third dose sars-cov-2 mrna vaccination.

this is a prospective, randomized open-labeled study of kidney transplant recipients who have previously received two doses of mrna covid-19 vaccine (either bnt162b2, pfizer-biontech or mrna-1273, moderna) and who are eligible to receive a 3rd dose of mrna vaccine.

Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the study * first or repeat kidney transplant recipient * negative or low positive antibody titer on sars-cov-2 antibody assay * on a mycophenolate or azathioprine based immunosuppressive regimen * \> 6 months post-transplant exclusion criteria: * pregnancy * contraindication to sars-cov-2 vaccination (severe allergic reactions or anaphylaxis)
hero vascular access device post market procedural survey protocol

Conditions: End Stage Renal Disease

Summary: post market observational survey of a vascular access device for access-challenged patients. data collection efforts focused on patient medical and access history and implant procedure results.

evaluation design: this is a multi-center post market observational survey designed to collect procedural data on a minimum of 50 hero™ patients in the commercialization phase. data will be collected retrospectively for patients already implanted with the hero™ device in the commercialization phase or prospectively for patients that receive the hero™ device during the data collection period. no special patient screening, testing, or procedures are required. there is no required patient follow-up. subject population: any patients the investigator deems/deemed eligible for hero™ implant with complete procedural data are eligible for inclusion in this post market observational survey. endpoints: none inclusion/exclusion criteria: there are no formal screening criteria other than patients must have all required procedural data points available for recording on the case report form.

Eligibility criteria:
inclusion criteria: * none exclusion criteria: * none

Keywords: end stage renal disease bacteremia hero vascular access device access challenged catheter dependent end stage renal disease requiring vascular access. see hero device instructions for use for appropriate patient population
is eswt better in plantar fasciitis treatment?

Conditions: Plantar Fascitis

Summary: it was aimed to compare the pain and functional results of eswt, kinesiotherapy and corticosteroid injection in patients with treatment-resistant plantar fasciitis.

the groups were randomized in patients with chronic plantar fasciitis who did not benefit from conservative treatment. a questionnaire study was conducted at the first visit, sixth week, third month, and sixth month. visual analog scale (vas) and the american orthopedic foot and ankle society (aofas) score were applied as a questionnaire at each control visit of the patients.

Eligibility criteria:
inclusion criteria: * previously diagnosed with pf, * did not benefit from conservative treatment for at least six months, * did not use anticoagulants, * did not have bleeding disorders, * did not have a psychiatric disease exclusion criteria: * previous eswt or ci treatment * obesity, * seronegative spondyloarthropathy, * tarsal tunnel syndrome, * peripheral neuropathy, * foot-ankle deformity (pes cavus, pes planus, etc.), * history of mass around foot and ankle, * previous foot or ankle surgery * degenerative arthritis around this region

Keywords: eswt kinesiotaping corticosteroid injection
cardiac resynchronization therapy modular registry

Conditions: Heart Failure

Summary: the purpose of the study is to collect some parameters (clinical, electrical, radiographic, echocardiographic and ecg) able to predict response to cardiac resynchronization therapy.

heart failure is a complex clinical syndrome characterized by a high prevalence and incidence in populations at greatest risk and, therefore, with a significant social and economic impact. randomized clinical trials, meta-analyzes, observational studies and controlled trials clearly demonstrated that the neuro-hormonal therapy is highly effective in reducing mortality, hospitalization and improving quality of life. in recent years the electrical therapy is playing an increasingly important role in the treatment of patients with chronic heart failure. such importance is mainly due to the possibility of preventing sudden cardiac death by implanting an icd and to correct the deleterious effects of electrical dyssynchrony and / or left ventricular mechanics by crt. the crt has proven an effective tool in reducing mortality, reducing symptoms and improving quality of life in patients already receiving optimal medical therapy. despite the undoubted benefits that the electrical treatment has added to conventional medical therapy, a high percentage of patients does not benefit in terms of clinical and echocardiographic. the identification of non-responders to crt is crucial in order not to submit the patients to an unnecessary and costly device whose electrical therapy proves to be ineffective. the reason for lack of response is still unclear but factors such as lead placement, device-settings and the degree of dyssynchrony before implant seems to be important. the purpose of the study is to collect some parameters (clinical, electrical, radiographic, echocardiographic and ecg) able to predict response to cardiac resynchronization therapy.

Eligibility criteria:
inclusion criteria: * chronic symptomatic hf despite stable, optimal drug therapy * indication for a cardiac resynchronisation device with or without defibrillator backup according to current guidelines * patients implanted with cardiac resynchronization device exclusion criteria: * patients participating in other studies that clearly impact the clinical practice of the center * patients who are unable to provide informed consent * patients who can not perform follow-up in the center

Keywords: cardiac resynchronization therapy heart failure
phase 2 study of opa-15406 ointment in pediatric patients with atopic dermatitis

Conditions: Atopic Dermatitis

Summary: to evaluate the safety, efficacy (dose response) and pharmacokinetics of 0.3% and 1% opa-15406 when applied twice daily for 4 weeks in pediatric patients with atopic dermatitis.


Eligibility criteria:
inclusion criteria: * diagnosis of atopic dermatitis based on the criteria of hanifin and rajka exclusion criteria: * subjects who have an atopic dermatitis or contact dermatitis flare-up defined as a sudden intensification of atopic dermatitis. * subjects who have an active viral skin infection. * subjects with a current or history of malignancy.