Kornimate/medical-research-clean huggingface dataset:
cxcl10 as a biomarker of ild in patients withra

Conditions: Interstitial Lung Disease in Patients With Rheumatoid Arthritis

Summary: rheumatoid arthritis is a chronic inﬂammatory disease that affects the joints, causing symmetric pain, stiffness, swelling, and limited motion and function of multiple joints, its ﬁbro inﬂammatory manifestations may develop in other organs.

rheumatoid arthritis is complicated by lung manifestations, such as interstitial lung disease which is the most common cause of morbidity and mortality in rheumatoid arthritis patients. rheumatoid arthritis-interstitial lung disease is a progressive fibrotic disease of the lung parenchyma that includes a broad spectrum of disorders such as nonspeciﬁc interstitial pneumonia, usual interstitial pneumonia , desquamative interstitial pneumonia, cryptogenic organizing pneumonia, diﬀuse alveolar damage, acute interstitial pneumonia, and lymphocytic interstitial pneumonia . rheumatoid arthritis-interstitial lung disease in which available data indicate that dysregulated inflammatory cascades can elaborate a host of cytokines, chemokines, and growth factors that collectively promote epithelial and endothelial cell damage, angiogenesis, fibroblast differentiation/proliferation, and lung fibrosis . given the clinical implications of putative signaling cascades involved in these processes, biomarkers that can be used to clarify disease pathogenesis and identify factors governing disease progression are clearly needed .

Eligibility criteria:
inclusion criteria: 1. adult rheumatoid arthritis patients who fulfilled the 2010 american college of rheumatology/european league against rheumatism criteria for the classification of rheumatoid arthritis. 2. adult rheumatoid arthritis patients with interstitial lung disease. exclusion criteria: 1. individuals with other autoimmune diseases (systemic lupus erythematosus, polyarteritis nodosa, dermatomyositis, scleroderma, spondyloarthritis and inflammatory bowel disease). 2. individuals with hepatitis, rhinovirus infection, cerebral malaria. 3. individuals with colorectal carcinoma, syndrome of frailty, vetiligo.
antiangiogenic factors in gastric cancer

Conditions: Gastric Cancer

Summary: endogenous antiangiogenic factors are related with gastric cancer progression.

gastric cancers have been known to secrete the proangiogenic cytokine vegf in vitro and in vivo. tumor vegf expression is correlated with the severity of disease in patients with gastric cancer and some authors have suggested using circulating vegf as a prognostic factor or tumor marker.in addition to producing proangiogenic cytokines, recent data demonstrate that tumors can produce antiangiogenic cytokine as well. it has been suggested that, in humans, the generation of antiangiogenic compounds in the presence of a primary tumor suppresses the growth of distant metastases. this phenomenon has been demonstrated in mice and in patients with clear cell renal cancer, breast cancer, and colorectal cancer. however, the presence of endogenous antiangiogenic cytokines in patients with gastric cancer has not been reported.

Eligibility criteria:
inclusion criteria: * histologic diagnosis of gastric adenocarcinoma * no other forms of cancer therapy, such as chemotherapy or radiotherapy for at least 3 weeks before the enrollment in study * performance status of 0, 1, 2 on the ecog criteria * asa class i, ii * patient compliance that allow adequate follow up * informed consent from patient or patient's relative. exclusion criteria: * second primary malignancy * emr (endoscopic mucosal resection) indication * laparoscopic gastrectomy * radiologic or clinical evidence of metastasis

Keywords: gastric cancer antiangiogenic factors tnm stage
does blood flow restriction training improve quadriceps function after arthroscopic knee surgery?

Conditions: Quadriceps Atrophy; ACL Reconstruction

Summary: the purpose of this study is to evaluate the effectiveness of physical therapy (pt) plus bfr training compared to pt alone (without bfr training) after acl reconstruction in patients who require extended limited weight bearing through assessment of patient reported outcomes and functional testing. the hypothesis is that pt plus bfr training will mitigate the loss of quadriceps muscle cross-sectional area, strength, and function while also improving early clinical and functional results.


Eligibility criteria:
inclusion criteria: * anterior cruciate ligament (acl) reconstruction with concomitant meniscus or cartilage restoration procedures * adherence to modified weight bearing status before initiation of pt * expected participation in recreational or competitive sports after release to full activities exclusion criteria: * unable to attend (or participate in) physical therapy * pregnancy * malignancy * fracture * peripheral vascular disease * history of deep vein thrombosis (dvt)

Keywords: anterior cruciate ligament reconstruction
nocturnal enuresis and rapid maxillary expansion

Conditions: Nocturnal Enuresis

Summary: nocturnal enuresis (ne) is the involuntary loss of urine that occurs only at night in children aged 5 years or more. ne is a common problem, affecting about 10% of school children. the prevalence declines with each year of maturity but for some it persists in to adolescents and early adulthood. it can lead to bad self-confidence and low self-esteem, which can have psychosocial consequences. ne is a multifactorial condition. three central factors have been identified: a) many bedwetting children produce large amounts of urine at night due to a deficiency of the antidiuretic hormone vasopressin. b) other children have a lack of inhibition of bladder emptying during sleep. c) almost all children are deep sleepers with high arousal thresholds. they simply don't wake up when the bladder is full or when it contracts. there are two well established and evidence based treatments today: the bed-wetting alarm and the pharmacologic treatment desmopressin. the alarm emits a sound when the child wets the bed, which conditions the child to wake up or inhibit bladder emptying. this method is curative for about half of the patients who try this, but relapse occurs. desmopressin is a synthetic analog of arginine vasopressin and works by decreasing the urine volume at night. about half of the patients become dry with this medication but only as long as they take the medicine. to day, at least 25% of all children with ne do not respond to any of the above treatment. rapid maxillary expansion (rme) is a common orthodontic technique to treat patients with a narrow upper jaw. the brace is fitted by an orthodontist, and has a jack-screw, which is activated twice every day for 10-14 days. the procedure is neither painful nor harmful and is not very visible at all. there are a few reports about children who have become dry after rme treatment. none of them have been randomised or placebo controlled but indicates that quite a few children do become dry after this treatment. a recently carried out study in sweden show that half of the children became dry after rme treatment. these children were all classed as therapy resistant and had already tried the alarm and medication without success. the reports are intriguing, but invite the question why a brace would help cure ne? it is likely that sleep and respiration is involved. this study will investigate these children's sleep during the treatment. the trial is a randomised, placebo controlled trial.


Eligibility criteria:
inclusion criteria: * patients aged 7-14 years old * at least 7 wet nights out of 14 exclusion criteria: * daytime incontinence * constipation * adhd

Keywords: nocturnal enuresis rapid maxillary expansion orthodontics polysomnography quality of life
primary subtalar arthrodesis for calcaneal fractures

Conditions: Calcaneus Fracture

Summary: management of severe injuries to the heel (displaced intra-articular calcaneus fractures) continues to be a major challenge for orthopedic surgeons. previous studies have demonstrated poor outcomes, and results show that patients experience long-term pain and decreased quality of life postoperatively. poor outcomes are driven by pain, in particular, which is linked to post-traumatic subtalar arthritis.

the goal of this clinical trial is to compare two surgical options for calcaneus fractures to determine best treatment for returning to work sooner in adults. participants will be randomized to one of two treatment options and will be asked to complete patient reported outcome measure surveys. researchers will compare open reduction and internal fixation (orif) + primary subtalar arthrodesis (psta) to orif alone to see which group returns to work at an earlier timepoint.

Eligibility criteria:
inclusion criteria: * undergoing operative treatment for displaced intra-articular calcaneus fracture * sanders iii and iv displaced intra-articular calcaneus fracture or sanders ii with any of the following criteria: bohler angle \< 0 degrees, open fracture, pain syndrome, substance use disorder * age 18 or older * able to follow up at site for 1 year exclusion criteria: * planned surgery using extensile lateral approach * sanders ii displaced intra-articular calcaneus fracture without: bohler angle \< 0 degrees, open fracture, pain syndrome, or substance * \<18 years of age * body mass index (bmi) \>40 * unable to follow up at site for 1 year * patients that speak neither english or spanish * prisoner

Keywords: heel injuries post-traumatic subtalar arthritis orthopaedic injury
18f-fes pet/ct's additional clinical value in er+ bc

Conditions: Breast Cancer

Summary: to figure out whethetr 18f-fes pet/ct could influence the staging and management of newly diagnosed oestrogen receptor-positive breast cancer patients.


Eligibility criteria:
inclusion criteria: * patients with newly diagnosed immunohistochemical confirmed oestrogen receptor (er)-positive breast cancer * patients underwent both 18f-fes pet/ct and 18f-fdg pet/ct in fudan university shanghai cancer center within 1 week after diagnosis * patients with available medical history exclusion criteria: * patients with incomplete medical history
simvastatin treatment of patients with acute optic neuritis

Conditions: Optic Neuritis; Multiple Sclerosis

Summary: the purpose of this study is to investigate if the simvastatin treatment improve the visual function after 3 months of the inclusion to this project and if the simvastatin influences the results on cerebral mri after 3 and 6 months of the inclusion. in addition the development of new demyelinating relapses. in the patients with monosymptomatic acut optic neuritis to investigate whether the simvastatin reduces the risk to develop multiple sclerosis (ms).

multiple sclerosis (ms) is a chronic inflammatory demyelinating disease in the central nervous system (cns). acute optic neuritis is a common symptom of ms and is considered to have the same pathogenesis as ms, where autoimmune and inflammatory mechanisms lead to the progression of ms. statins reduce the cholesterol in blood and in addition have anti-inflammatory effects. from experimental data and results from pilot projects there is evidence that the statins perform anti-inflammatory and immune-modulatory effects and one can expect a beneficial outcome in the autoimmune inflammatory diseases after the treatment with statins.

Eligibility criteria:
inclusion criteria: * acute optic neuritis * abnormal contrast sensitivity score (\>80) * symptom duration maximum 4 weeks * men and women between 18 and 59 years old * the patient must be physical and mental able to participate i this project with a 6 months of the duration * the patient must sign the written consent of the participation before the inclusion. exclusion criteria: * optic neuritis earlier in the same eye * pregnancy * nursing * fertile women who do not use contraception * women who contemplate pregnancy in the duration of the study * steroid treatment the last 4 weeks before the inclusion * immune-supressor treatment the last 6 months before the inclusion * active liver disease or continuous increase of liver enzymes (asat, alat)without known reason. * kidney failure * myopathy * hyperthyroidism * diabetes mellitus * alcoholism * fibrates intake * statin treatment for other disease * simultaneous participation in other studies.

Keywords: simvastatin optic neuritis multiple sclerosis
effects of supervised physical therapy with early activation of the rotator cuff versus home exercises in patients after arthroscopic subacromial decompression

Conditions: Subacromial Decompression

Summary: the objective of this study was to evaluate and compare two different post-surgical rehabilitation strategies, rehabilitation supervised by a physical therapist including exercises with progressive early activation of the rotator cuff versus basic home exercises regarding shoulder function, pain, health related quality of life and return to work after arthroscopic subacromial decompression.

patients scheduled for surgery (arthroscopic subacromial decompression)and in the age 25-65 were offered to participate in the study. after surgery they were randomized to either supervised physical therapy with early activation of the rotator cuff (pt-group) or to home exercises (h-group). patients in the pt group met the physical therapist twice a week for exercises and in between these visits they did their exercises at home daily. the h-group did home exercises daily. shoulder function and pain(primary outcomes)and health related quality of life, returning to work(secondary outcomes)were assessed before surgery, one week after(baseline), 1,2,3 and 6 months after surgery by an independent physical therapist.

Eligibility criteria:
inclusion criteria: * subacromial impingement verified with neer impingement test * at least 6 month duration of pain * treated in primary care without satisfactory results for at least three months. * typical history and pain location. scheduled for surgery (subacromial decompression) * three of these four tests must be positive: * neer impingement test * hawkins-kennedy impingement sign jobe supraspinatus test * painful arc 60-120 degree exclusion criteria: * radiological findings of malignancy osteoarthritis, fractures * polyarthritis or fibromyalgia * pathological hyper laxity * lack of communication skills that prevent the use of outcome measurements * cervical spine pathology

Keywords: arthroscopic subacromial decompression exercise physical therapy rotator cuff shoulder impingement syndrome subacromial impingement after arthroscopic subacromial decompression
rapid evaluation of pandemic h1n1 influenza vaccine in aboriginal children and adults

Conditions: H1N1/2009 Influenza

Summary: the purpose of this study is to assess the safety and effectiveness (immune response) to a licensed h1n12009 influenza vaccine in aboriginal children and adults. the study will enroll 200 healthy adults (ages 20-59 years) and 75 healthy children (ages 6-35 months). adults will receive one dose of a licensed h1n1 vaccine and children will receive two doses of a licensed h1n1 vaccine approximately 3 weeks apart. study procedures include: medical history, blood samples and completing a memory aid. participants will be involved in study related procedures for approximately 3 weeks (adults) or 6 weeks (children).

during the first wave of the h1n12009 pandemic in canada, persons of aboriginal background were more often hospitalized with severe infections than were other canadians. among first nations members the hospitalization rate was 5 times higher than the national average. common risk factors were young age (children and younger adults) and underlying health conditions. a high proportion of aboriginal adults have health conditions that predispose to adverse influenza outcomes, including diabetes, asthma, obesity and smoking-related lung diseases. aboriginals could benefit substantially from timely, effective vaccination against pandemic influenza and are expected to be among the first canadians to be offered vaccine when available. the vaccine dosing recommendation will be based on limited studies in the general population, leaving open the question of whether aboriginals will respond satisfactorily to the recommended dosing. unique social and biological factors among aboriginals could affect their responses to vaccination, reducing protection or increasing adverse effects. thus it would be optimal to evaluate the safety and immunogenicity of the pandemic vaccine among the earliest aboriginal recipients, to inform the subsequent vaccination of other aboriginal groups. the objectives of this study are two-fold: 1. to evaluate the safety and immunogenicity of h1n12009 influenza vaccine in a convenience sample of children and adults of aboriginal background (first nations, metis and inuit) with emphasis on subgroups at greatest risk of severe disease. 2. to complete this evaluation soon after the pandemic vaccines become available so as to inform the subsequent use of the vaccines in the aboriginal population.

Eligibility criteria:
inclusion criteria: * good general health * written informed consent provided by or for the subject * aboriginal ethnicity (first nations, metis or inuit) * adults 20-59 years of age * children 6-35 months of age exclusion criteria: * allergies to eggs, thimerosal or gentamicin sulphate * life-threatening reaction to previous flu vaccine * bleeding disorder * pregnancy * receipt of blood or blood products in past 3 months * compromised immune system * chronic illness * previous lab-confirmed h1n1/2009 infection

Keywords: vaccine h1n1 influenza h1n1 influenza vaccine pandemic
social virtual-reality on enhancing social interaction skills in children with attention-deficit/hyperactivity disorder

Conditions: Virtual Reality; Social Interaction; Attention-deficit/Hyperactivity Disorder

Summary: the study targets children with diagnosed adhd and aims to (1) develop a social virtual reality-based intervention, (2) investigate its effects on improving the social skills and executive functioning of inhibitions, emotional control and attention of the children compared to traditional social skills training and (3) evaluate the subjects acceptability and compliance with social vr training for enhancing social interaction skills. it is hypothesised that the social interaction skills of the participants in the social vr training group are likely to perform better than those in the traditional social skills training group. participants in the waitlist control group will receive no change in social interaction skills compared with the two intervention groups.

the study will be a three-arm randomised controlled trial comparing the effects of social vr-based intervention with traditional social skills training on social skills and executive functioning of children with adhd. participants in the social vr intervention group and traditional social skill training group will receive 12 training sessions for 3 weeks (4 sessions per week), and participants in the waitlist control group will be asked to retain their usual lifestyles for 3 weeks.

Eligibility criteria:
inclusion criteria: * aged between 6 and 12 years * ethnic chinese * residing in hong kong * having received a diagnosis of adhd by child assessment service in hong kong or via private practice * stable on pharmacological and/or psychological treatment for adhd 8 weeks before baseline (determined by health care professionals on the basis of medication data and behavioural observation) * no initiation or change of pharmacological treatment for adhd during the intervention period * the ability to read chinese, and speak and listen to cantonese by the child and by at least one of their parents or legal guardian * willing to provide informed consent by both participants and one of their parents or legal guardian exclusion criteria: * comorbid autism * mental retardation * an estimated iq lower than 85 (using the wechsler intelligence scale for children - fourth edition (hong kong) (wisc-iv(hk))) * autism spectrum disorder (previously diagnosed by health care professionals) * comorbid acute psychiatric disorder (previously diagnosed by health care professionals) * with a severe physical disability (e.g., blindness, deafness) or learning disability (e.g., dyslexia).

Keywords: virtual reality social interaction attention-deficit/hyperactivity disorder three-arm pilot randomised controlled trial
simvastatin effect on portal hypertension

Conditions: Portal Hypertension; Esophageal Varices; Liver Cirrhosis

Summary: it´s a clinical research of the effects in portal hypertension caused by simvastatin. we are going to use the hepatic venous pressure gradient(hvpg) measurement and the azygos flow at echoendoscopy to evaluate the benefits of the drug. preliminary studies demonstrated that simvastatin can lower portal pressure.

the simvastatin can target the liver enhancing nitric oxide intra-hepatic and lowering resistance that may be responsible for most of cirrhosis complications. indeed, the potential use of this drug may ameliorate the hvpg and azygos flow. portal hypertension is responsible for most of the cases of death in cirrhosis. the esophageal varices, ascites and hepatorenal syndrome are the most harmful consequences of cirrhosis that should be prevented. in that way, simvastatin appears as a promising therapy.the study will include two groups of patients using aleatory randomization and one group will receive simvastatin while the other will receive placebo blindly. at the start and at the end of the study the patients will be submitted to hvpg measurement and azygous vein flow measure. the endpoints will be the normalization of hvpg or lower significantly(20% or more. the patients will be followed for 6 months after the end of the study.

Eligibility criteria:
inclusion criteria: * portal hypertension: esophageal varices, ascites, splenomegaly or hepatorenal syndrome. exclusion criteria: * child-pugh c decompensated or encephalopathy * malignancy except basocellular cancer * hepatocarcinoma * anti-viral therapy * hiv * prevention of digestive hemorrhage with band ligation or sclerotherapy for the last 6 months

Keywords: portal hypertension hepatic venous pressure gradient esophageal varices liver cirrhosis simvastatin nitric oxide hvpg
roscap: reduction of smoking in cardiac patients study

Conditions: Nicotine Dependence; Tobacco Dependence; Cardiac Disease

Summary: background. the roscap study was a randomized controlled trial in heart disease patients to test the effect of a smoking reduction intervention on cigarettes per day (cpd) and biochemical and clinical indicators of tobacco exposure. .


Eligibility criteria:
inclusion criteria: * smoked at least 15 cigarettes per day and had one of 11 cardiovascular disorders: history of myocardial infarction, coronary artery bypass surgery, angioplasty, stent placement, thrombolytic therapy, angina, arrhythmia, a history of cardiac arrest, greater than 50% coronary artery stenosis by angiography, ischemia on exercise tolerance testing or congestive heart failure, required to confirm that they were unwilling or uninterested in setting a stop smoking date in the next 30 days. exclusion criteria: * 1) unstable angina within the past 2 weeks, 2) unstable psychiatric or substance use disorders or 3) contraindications to nicotine replacement therapy (including pregnancy or intention to become pregnant)

Keywords: tobacco nicotine smoking reduction