temporal interference neurostimulation and addiction

Conditions: Nicotine Use Disorder; Substance Use Disorders

Summary: this project aims to develop a line of research using new non-invasive neurostimulation technology to treat adults with opioid use disorders (ouds). in the short term, the investigators aim to identify novel target brain regions for neurostimulation treatment and characterize their effects behaviorally and neurally. in the longer term, investigators aim to use these preliminary data to justify nih sponsored clinical trials to apply transcranial direct current stimulation and non-invasive deep brain stimulation to these areas to partially or completely disrupt addiction.

the investigators hypothesize that temporal interference non-invasive deep brain stimulation (ti-ndbs) will be well tolerated and effective at manipulating brain activity and reducing drug cravings. the investigators will investigate whether stimulation with a mild current from temporal interference non-invasive deep brain stimulation (ti-ndbs) to the anterior cingulate cortex (acc), the anterior insula (ai), or the nucleus accumbens (nacc) will reduce nicotine craving and seeking. the ti-ndbs is similar to the traditional transcranial direct current stimulation (tdcs), a method approved for use in a number of other studies. other studies have shown there have been some effects of reducing craving with tdcs, however, tdcs cannot stimulate structures such as the acc very effectively because tdcs cannot stimulate deeper brain regions. thus, the specific aim ultimately will compare ti-ndbs with tdcs and sham stimulation. the study is broken up into four phases. the first two will involve device feasibility and identifying the best locations for the electrodes to be placed. in the third phase, the investigators will compare ti-ndbs with sham stimulation. in the fourth phase, the investigators will compare ti-ndbs with sham stimulation and with tdcs.

Eligibility criteria:
inclusion criteria: * must be between the ages of 18 and 40, must have at least 6th grade education, and the ability to speak and read english, must smoke at least 3/4 of a pack of cigarettes per day, must have phone with internet access. exclusion criteria: * if they are on psychotropic medications for adhd, other mental illness or medication for cancer, epilepsy (i.e. individuals with any history of seizure disorder), migraines, or other neurological syndromes, or aids (which can cause cognitive deficits (watkins \& treisman, 2015), history of head trauma, history of cognitive impairments, metal implants in the head or under the scalp, personal experiences consistent with symptoms of psychosis (i.e. mind or body being secretly controlled, special powers, seeing or hearing things that aren't really there). * subjects will be excluded if they do not meet fmri safety screening criteria (i.e. metal implants in their body, tattoo on head or neck, permanent jewelry, etc.) or if a participant uses an iud for birth control they will be excluded unless the subject can document the model of the iud and we can verify its safety for the mri environment. pregnancy should be self-reported, and a pregnancy test will not be administered. participants must also weigh less than 440 lbs. * history of holes bored into skull or known fissures in cranial bones * presence of pacemakers

Keywords: nicotine addiction non-invasive deep brain stimulation substance use disorders