Kornimate/medical-research-clean huggingface dataset:
catheter ablation versus thoracoscopic ablation to patients with permanent atrial fibrillation

Conditions: Atrial Fibrillation

Summary: patents with atrial fibrillation can be treated with the purpose of curing the arrhythmia.this may be achieved by catheter ablation and maze surgery where the latter includes open heart surgery. by catheter ablation the arrhythmia can be cured in about 70 % of patients who have episodes of atrial fibrillation. in patients with permanent atrial fibrillation the results are not as good. we will compare a conventional ablation approach where lesions are created on the inside of the heart with a thoracoscopic approach where the lesions are created from the outside of the heart.

patients with permanent atrial fibrillation will be considered for randomisation patients will be randomised to either conventional endocardial catheter ablation or epicardial thoracoscopic ablation. objectives of study: primary endpoint:presence of sinus rhythm after 6 months secondary endpoints: complications, cost-effectiveness, structural changes (evaluated by echocardiography), p-bnp and inflammatory markers, atrial fibrillation burden evaluated by holter monitoring

Eligibility criteria:
inclusion criteria: * permanent atrial fibrillation documented on at least 2 ecg´s with more than 1 month between ecg´s. the diagnosis is verified on holter. * all patients have symptoms or do not tolerate rate control treatment. exclusion criteria: * psychiatric disease or suspicion of incapability to give informed concent * females with birth giving potential * previous heart surgery * previous ablation for atrial fibrillation * life expectance less than 1 year * congenital heart disease * expected need for heart surgery * heart failure (nyha class iv) * inability to be treated with anticoagulation * in case of previous deep venous thromboembolism og stroke the investigators will individually consider if the patient is suitable for inclusion.

Keywords: atrial fibrillation permanent atrial fibrillation catheter ablation thoracoscopy arrhythmia heart
prospective study of methicillin-resistant staphylococcus aureus (mrsa) among hiv-infected persons

Conditions: HIV Infections; Staphylococcal Infections

Summary: this study will prospectively evaluate the prevalence and incidence (over a two year period) of mrsa colonization and infection among hiv-infected military beneficiaries to determine predictors for the development of mrsa colonization and infection. this study will also investigate the utility of decolonization procedures for clearance of mrsa carriage and prevention of mrsa infections. finally, the molecular characteristics and the antimicrobial sensitivities of isolates in this population will be determined.


Eligibility criteria:
inclusion criteria: * adults (at least 18 years of age) who are hiv positive by a reactive screening (elisa, eia) and a confirmatory test (western blot) and who are able to attend the study visits which are every 6 months (+/- 2 months), at the minimum exclusion criteria: * known allergy to mupirocin (bactroban®) nasal ointment or hexachlorophene (phisohex®) soaps or constituents of these products. * age less than 18 years. * inability to remain in the study for the two year duration. * pregnant or breastfeeding females. * females who intend to become pregnant during the two year study time period. * persons who are healthcare providers with direct patient contact.

Keywords: hiv methicillin-resistant staphylococcus aureus (mrsa) hiv and staphylococcus aureus infection
fluid resuscitation goal in early stage of severe acute pancreatitis

Conditions: Pancreatitis

Summary: to compare different goals of fluid resuscitation in early stage of acute pancreatitis

with regard to study of sepsis and several studies of sap demonstrating the deleterious effects of fluid loss and haemoconcentration within the first 24h after admission（or onset of abdominal pain）, early goal-directed fluid resuscitation has the potential of improving outcome also in sap. but the goal of fluid resuscitation remained controversial.several criteria of fluid resuscitation had been described. ours had been described in previous study, and had shown a ideal result with less incidence of abdominal compartment syndrome and higher survival rate. this study aims to determine a better goal of fluid resuscitation in severe acute pancreatitis.

Eligibility criteria:
inclusion criteria: * 1. diagnosis of pancreatitis: typical pain increase in serum lipase or amylase 2. onset of abdominal pain within \ = 1 predictor of fluid resuscitation: haematocrit \>44% (male) or \>40% (female), respectively lactate\>4mmol/l; heart rate\>120bpm; urine \ 85 or \<60 mmhg exclusion criteria: * 1. pregnancy 2. new york heart association classification \>ii 3. with pacemaker implantation 4. chronic obstructive pulmonary disease 5. chronic kidney disease 6. pre-existing disease with life expectancy \< 3 months

Keywords: pancreatitis resuscitation goal
new service protocol for attention deficit/hyperactivity disorder with comorbidity: a randomized waitlist-controlled

Conditions: ADHD

Summary: the proposed study is to be carried out in 2021 - 2024 with youths aged 6 - 15 in hong kong. this is a randomized waitlist-controlled trial that aims to examine the effectiveness of the adhd+ new service protocol. this adhd+ new service protocol intervention will be delivered for 6 months in the format of groups by frontline social workers trained by professional clinicians including clinical psychologists and psychiatrists. it is designed to reduce adhd and related symptoms in individuals aged between 6 and 15 years. core treatment components include internet use/addiction intervention, cognitive training, emotion management, social skills training, occupational training, emotion support/befriending, parenting training, and career guidance. it is hypothesized that youths receiving the intervention will have reduced adhd and related symptoms when compared with controls. findings will allow the investigators to better understand the effectiveness of the new adhd+ service; and in the long run, the service model can be generalized to community based early interventions for other uncomplicated mental disorders.


Eligibility criteria:
inclusion criteria: * children, adolescent and young adults (aged 6-15); * have sufficient proficiency in chinese to understand verbal instructions and give informed consent; * clinically significant mild to moderate adhd syndromes requiring intervention; * without learning disabilities and intelligence quotient (iq) score not lower than 70; * are "more likely to commit time in the projects" for reasons such as intention to treat and * receiving the new adhd+ service. exclusion criteria: * known diagnosis of intellectual disability; * not reaching syndrome diagnostic threshold for adhd; * already receiving medical interventions / treatments at hospital authority (ha) and/or private sector; * known psychiatric diagnosis (stabilized diagnosis and treatment); * current or active suicidal ideation or attempts; * have received structured psychosocial intervention for more than 3 contact hours (for waitlist group); and * refusal to give consent.
the effect of hand and back massage on pain, sleep and self-care in women undergoing hysterectomy

Conditions: Sleep; Pain; Self Efficacy

Summary: postoperative incision pain is an acute pain that begins with the stimulation of neuroreceptors from surgical trauma and usually resolves within a few days. today, the physiology of acute pain is better understood and new approaches to pain management are emerging. however, studies conducted in recent years have reported that postoperative pain management is inadequate, and therefore approximately 50-80% of patients still experience moderate to severe pain

self-care is the realization of health activities to maintain one's health, life and well-being (14). self-care power is at different levels in each person and perceptual, cognitive, interpersonal and psychomotor characteristics are needed for an effective self-care power to be formed. therefore, self-care power varies according to the ability and health status of the individual (12). according to orem, the development and maintenance of health are the results to be obtained through self-care. orem's theory also "values personal responsibility for health and indicates that nursing services may have a key role in prevention and health education". since self-care is a learnable behavior, nurses can encourage and support people's self-care efforts and increase the individual's participation by providing health education (12). when the literature is examined, there are a limited number of studies examining the effect of back massage on pain in women undergoing hysterectomy surgery. there are studies examining the effect of reiki on pain in different fields (13,14). pain is a condition that affects all dimensions of the individual including biophysiologic, psychological, sociocultural and political-economic. although analgesics are indispensable to alleviate postoperative pain, undesirable effects may occur when overused. therefore, nurses' use of non-drug methods in addition to pharmacologic methods will increase the effectiveness of pharmacologic methods (15). pharmacology

Eligibility criteria:
inclusion criteria: * age range 25-65, * elective surgery, * lying in the hospital for at least 2 days after surgery, * operated under general anesthesia exclusion criteria: * no serious complications developed after surgery, * never had a back or hand massage before, * cognitive, effective and without any problem preventing communication, * no psychiatric problems, * patients receiving a single type of analgesic drug (non-narcotic analgesics) to ensure homogeneity of the groups and to increase the reliability of the study results, * patients not using patient controlled analgesia (pca) will be included in the sample.
change clubs for african american women

Conditions: Obesity; Cardiovascular Disease

Summary: african american women have among the highest rates of overweight and obesity and few meet dietary or physical activity guidelines. the investigators seek to develop a new intervention strategy that will help alleviate health disparities, thereby improving quality of life, health care costs, and disease burden. the african american collaborative obesity research network (aacorn) recommends an eco-social, community-engaged approach to behavior change that is in line with cultural values of interconnectedness and care for others. the purpose of this study is to operationalize the aacorn paradigm to promote improvements in weight status and health through a civic engagement approach. to achieve this, participants will meet in church-based change clubs and be led through a 6 month curriculum, which includes both lessons in cardiovascular risk reduction and a civic engagement project. civic engagement may lead to change in individual health behaviors by increasing self-regulation and self-efficacy. the investigators will measure club members' adherence to the change club intervention, defined as average number of sessions attended, retention in the clubs, satisfaction with the change club experience and achievement of at least 50% of self-identified benchmarks for community change within 6 months. in addition the investigators will compare anthropometric factors, diet and physical activity behaviors, blood pressure, cardiorespiratory fitness, and psychosocial factors before and after participation in the change club intervention.


Eligibility criteria:
inclusion criteria: * female; * age 30-70 years; * self-identified as african american; * english-speaking; * bmi ≥25.0; * currently sedentary (not meeting physical activity guidelines for americans); * safe to initiate moderate physical activity per the par-q. exclusion criteria: * failure to provide informed consent; * participation in any other lifestyle modification program; * current use of either prescription or over-the-counter weight loss medications; * inability to communicate due to severe, * uncorrectable hearing loss or speech disorder; * severe visual impairment (if it precludes completion of assessments and/or intervention); * planning to move outside of area within 6 months; * pregnancy (since weight loss, the primary outcome, is inadvisable in this population).
telemedicine and humidification for cpap in osas key treatment (think study)

Conditions: Sleep Apnea, Obstructive; OSA; Sleep; Sleep Disorder; Hypersomnia

Summary: the goal of the study is to test the role of telemedicine combined with humidification to check cpap treatment during the first month to improve adherence and reduce unsolved side effects of therapy.

the primary goal of osas therapy is to obtain cpap adaptation for the highest amount of osas patients to reduce the proportion of untreated osas in the population. this object is important considering that a longer duration of cpap treatment is linked with better daytime functioning and metabolic and blood pressure effects of cpap. the main endpoints will be cpap usage (defined as the proportion of night with cpap usage ≥1h); cpap adherence (defined as the proportion of night with cpap usage ≥4h); the average nightly usage of cpap (hour/night); cpap efficacy (defined as ahi and ess score). each measure will be performed after 1 week, 1 month and 6 months.

Eligibility criteria:
inclusion criteria: • consecutive symptomatic osas patients with an ahi and an oxygen desaturation index (odi) of \>15/h in polysomnography (psg) or home sleep test (hst) consenting to start long term cpap treatment. exclusion criteria: * age \<18 years * unable to communicate in italian * previous usage of cpap treatment * alcohol consumption \> 4 units \>4 times a week * acute manifestation of psychiatric diseases * life expectancy of \< 6 months for any reason * surgical obesity treatment planned within the next 6 months * predominantly central sleep apnea and cheyne stokes respiration

Keywords: telemedicine cpap
use of fissure sealants on primary molars

Conditions: Dental Caries

Summary: sealants have been shown to be the most effective caries preventive measure in permanent dentition. sealants of the primary molars soon after they erupt would reduce the total caries experience of the primary teeth of the children and could possibly also postpone the caries process in the permanent dentition. the aim of this study is to measure the caries preventive effect of sealants in primary molars. the specific objectives are: 1) to compare the number of new caries experience teeth and surfaces among the intervention group of 4-years old pre-school children during the 1 year follow-up period, 2) to compare the preventive effect of sealants with fluoride varnish on the caries experience on the occlusal surfaces of the primary molars and on the total caries experience of all the primary and permanent teeth, 3) to test the feasibility of the sealant program in one kindergarten in kuwait city.


Eligibility criteria:
inclusion criteria: * positive written informed consent received from parents exclusion criteria: * if caries lesions in primary molars are so extensive that restorative treatment is needed

Keywords: dental caries fissure sealant fluoride varnish primary molar
uplyft for lymphoma survivors

Conditions: Lymphoma; Survivorship

Summary: the main purpose of this study is to field test and pilot an intervention called uplyft (understand and prevail: lymphoma fear of recurrence therapy) that includes information about lymphoma survivorship and tools to improve quality of life and reduce lymphoma-related worries among lymphoma survivors.

this is a two phase pilot study to develop and pilot the uplyft (understand and prevail: lymphoma fear of recurrence therapy) program intervention that includes lymphoma survivorship information and acceptance and commitment therapy strategies to alleviate fear of cancer recurrence, reduce distress, and improve quality of life among lymphoma survivors. phase 1 will be a two-part development process of the uplyft program based on interview feedback from lymphoma and mental health clinicians and then feedback from a six-person group of lymphoma survivors after participation in an uplyft program field test. phase 2 is a randomized pilot study using the uplfyt program finalized in phase 1. research procedures include: * in depth interview (lymphoma and mental health clinicians) * screening for eligibility * 6 weekly intervention sessions (lymphoma survivors) * baseline assessments and questionnaires (lymphoma survivors) 74 people are expected to participate in this study with 14 in phase 1 and 60 in phase 2. the american society of hematology is providing funding for the trial.

Eligibility criteria:
inclusion criteria: lymphoma survivors phase 1 and 2: * diagnosis of lymphoma (indolent non-hodgkin lymphoma, aggressive non-hodgkin lymphoma, or classic hodgkin lymphoma) * age ≥ 18 years * interval of 3 months to 24 months from completion of first-line treatment * in complete remission after first line of treatment * clinically significant fcr (score of ≥ 16 on the validated fcr inventory-severity subscale \[fcri-ss). * access to computer (for videoconferencing) lymphoma clinicians and mental health clinicians phase 1: * lymphoma clinicians ≥ 1 year from oncology fellowship completion or mental health clinicians (psychologists, social workers, psychiatrists) ≥ 1 year from completion of clinical training. * longitudinal clinical care for patients with lymphoma by oncologists or provision of care for patients with cancer by mental health clinicians exclusion criteria: lymphoma survivors phase 1: * age \< 18 years * concurrent other malignancy * patients with uncontrolled/untreated psychotic disorders or untreated bipolar and borderline personality disorder (as ascertained from medical record screen). lymphoma survivors phase 2: * age \< 18 years * concurrent other malignancy * patients with uncontrolled/untreated psychotic disorders or untreated bipolar and borderline personality disorders (as ascertained from medical record screen). * our study will exclude members of the following special populations: * adults unable to consent * individuals who are not yet adults (infants, children, teenagers) * pregnant women * prisoners

Keywords: lymphoma survivorship
effect of cervical cerclage with vaginal progesterone in asymptomatic twin pregnancies with a sonographic short cervix

Conditions: Twin; Pregnancy, Affecting Fetus or Newborn

Summary: the objective of the present study is to evaluate the effectiveness of vaginal progesterone and cervical cerclage each alone and in combination in improving gestational age in twin pregnancy and its subsequent impact on perinatal outcome.

there is a lack of effective, evidence-based interventions for the prevention of preterm birth in twin pregnancies. there is limited evidence for the use of vaginal progesterone and cervical cerclage, and the cervical pessary is currently only used within a research setting. there are no reported trials comparing the effectiveness of each of these interventions against each other, whether in isolation or in combination. research is needed to further evaluate the benefit of the cervical pessary and the use of cervical cerclage in twins of women with a short cervix. a recent article by stock et al.concludes by advising clinicians to share with women the uncertainty of methods to prevent ptb in multiple pregnancies, and offer the opportunity to participate in clinical trials. so the objective of the present study is to evaluate the effectiveness of vaginal progesterone and cervical cerclage each alone and in combination in improving gestational age in twin pregnancy and its subsequent impact on perinatal outcome.

Eligibility criteria:
inclusion criteria: * women pregnant in dichorionic twins. * transvaginal sonographic cervical length is \<25 mm at 16-20 weeks gestational age. * no symptoms, signs or other risk factors for preterm labor exclusion criteria: * age \ 45 years. * known allergy or contraindication (relative or absolute) to progesterone therapy. * monochorionic twins. * known major fetal structural or chromosomal abnormality. * intrauterine death of one fetus or death of both fetuses. * fetal reduction in the current pregnancy. * medical conditions that may lead to preterm delivery. * rupture of membranes. * vaginal bleeding

Keywords: preterm birth twin gestation vaginal progesterone cervical cerclage
comparison of karyotyping, cma and nipt for prenatal diagnosing chromosomal anomalies

Conditions: Prenatal Diagnosis

Summary: this diagnostic test is aimed to compare the karyotyping, cma and nipt for prenatal diagnosing chromosomal anomalies. pregnant women who needed prenatal genetic diagnosis meted the study criterion; fetal amniotic fluid was regular examined by karyotyping and cma, and maternal peripheral blood was collected for nipt detecting. and the cma result as a golden standard, the main outcome is compared the diagnostic efficacy of nipt for diagnosing chromosomal anomalies.

aim: to compare the karyotyping, cma and nipt for prenatal diagnosing chromosomal anomalies. design: diagnostic test set: prenatal diagnosis center of taizhou city study population: the pregnant women who needed amniocenteses for prenatal genetic diagnosis were recruited. methods: amniotic fluid was regular examined by karyotyping and cma, and maternal peripheral blood was used for collected for nipt detecting. statistic: cma result as a golden standard, the main outcome is compared the diagnostic efficacy of nipt for diagnosing chromosomal anomalies.

Eligibility criteria:
inclusion criteria: 1. pregnant women who needed amniocenteses were recruited during the study period, include high risk for serum screening, aged over 35 years and ultrasound abnormal. 2. only singleton were included exclusion criteria: 1. women who met the contraindication for invasive procedure as : threaten abortion, acute infectious disease. 2. women who unfitted for nipt analysis include multiple, history of allogeneic blood cell transfusion.

Keywords: prenatal diagnosis non-invasive prenatal tests chromosome microarray analysis
cardiovascular disease mortality in the nas-nrc twin registry

Conditions: Cardiovascular Diseases; Heart Diseases; Hypertension; Diabetes Mellitus; Obesity; Coronary Disease; Myocardial Ischemia

Summary: to analyze cardiovascular disease mortality and total mortality in the nas-nrc twin registry using a new methodology that allowed for censored observations of outcomes, environmental covariates, and unmeasured genotype-environment interactions.

background: methodologically, statistical methods in genetics and epidemiology have developed largely independently; and as a result, there seemed to be little communication between the two fields. some of the most important hypotheses regarding familial aggregation of chronic diseases related to gene-environment interactions which drew on both fields. the method of analysis used in this study dealt simultaneously with survival time nature of the outcome variable, multiple and continuous environmental risk factors, and correlation in outcomes between related individuals. the study was supported by the small grants program established by the national heart, lung, and blood institute in january 1990 to extend analyses of research data generated by clinical trials, population research, and demonstration and education studies. design narrative: data available from two epidemiologic questionnaires administered ten years apart were used to determine the extent to which an increased familial risk in cardiovascular disease mortality among twins was mediated by similarities in behavioral risk factors such as smoking, diet, weight changes, physical activity, and socioeconomic variables. the contributions of genetic and environmental factors to twin similarities in health behavior were also examined. the study completion date listed in this record was obtained from the "end date" entered in the protocol registration and results system (prs) record.

Eligibility criteria:
no eligibility criteria