Kornimate/medical-research-clean huggingface dataset:
use of equity report cards to mitigate disparities in emergency medical services (ems) care for injured children

Conditions: Pain, Acute

Summary: this trial will assess whether development and sharing of 'equity report cards' focussed on the recognition and treatment of pain for injured children by emergency medical services (ems) can help decrease disparities by race and ethnicity.

this is a pragmatic trial using an interrupted time-series design. the investigators will collect two years of retrospective data to establish a baseline. at month 2 the investigators will distribute ems agency-level 'equity report cards' to both agency leadership and all frontline ems providers. this 'equity report card' will contain monthly pooled, agency-level information summarizing clinical data for injured children stratified by race/ethnicity. at month 7 the investigators will also distribute battalion-level 'equity report cards' to agency leadership and all frontline ems providers. the 'equity report card' will include baseline historical data and a 3-month rolling average for each of the study outcomes. the 'equity report card' will also include an action plan with evidenced based recommendations specifically targeted to improve care. the outcomes for this study include both process measures (including documentation of pain scores, administration of any analgesia and administration of opiate analgesia) and also patient-centered clinical outcomes (reduction of pain as reported by the patient). these key study outcomes align with performance measures developed by the national ems quality alliance (nemsqa). patient race and ethnicity will be abstracted from the ems medical record. the investigators will also collect data regarding potential confounding variables including patient age, sex, geographic location of encounter and other dispatch details. the investigators will conduct an interrupted time series analysis (itsa) to evaluate the magnitude and statistical significance of the average difference (intercept) and difference between trajectories (slopes) for our 24 month control (t0) and each of the two intervention 5 month time periods (t1 and t2). this will allow the investigators to measure the impact of each additional intervention (ems agency-level followed by the addition of battalion-level 'equity report cards').

Eligibility criteria:
inclusion criteria: * children less than 18 years old * assessed by district of columbia fire and emergency medical services (dc fems) * injury related chief complaint, primary or secondary impression exclusion criteria: - none

Keywords: racial groups
the effect of two short education programs for nonspecific low back pain in a workers' health care organization

Conditions: Low Back Pain

Summary: the purpose of this study is to assess the effect of two different types of health education programs on the disability, beliefs related to low back pain and duration of sick leave in patients seen at a workers' health care organization


Eligibility criteria:
inclusion criteria: * low back pain patients, with or without referred or radiated pain * no systemic disease or criteria for referral to surgery exclusion criteria: * inability to fill out the questionnaires and scales * bedridden * rheumatologic inflammatory disease, cancer or fibromyalgia * suspicion of fibromyalgia * spinal fracture

Keywords: nonspecific low back pain disability sick leave catastrophizing workers
computerized eye-tracking attention training for children with special needs

Conditions: ADHD; ASD; Learning Disorders

Summary: children with special needs (e.g. autistic spectrum disorder, attention deficit hyperactivity disorder) are found to have sustained attention problems. several behavioral interventions have been carried out in the past to improve this situation. however, these interventions are often involved a high administration cost. recently, researchers have been focusing on training the eye gaze fixation using the eye-tracking training games, as some of the research studies reported a correlation between atypical eye gaze patterns with poor sustained attention. the objective of the present study is to evaluate the effectiveness of a computerized eye-tracking attention training. two batches of 48 primary school students will be recruited from email and the subject pool of the department of psychology of the chinese university of hong kong. participants are dividedly randomly and equally into either intervention or control group. participants in both groups will undergo pre- and post-assessments measuring the executive function and attention before and after the intervention, respectively. however, there will be eight eye-tracking training sessions for the intervention group, but only the assessments are received in the control group. it is hypothesized that after the training, the performance of the training games and assessments will improve, indicated by increasing accuracy rates, as well as the reaction time of the tasks. the results would provide important information on the value of computerized eye gaze training and would guide the direction of interventions that target on improving the sustained attention and impulse control of children with special needs.


Eligibility criteria:
inclusion criteria: * a total of 96 primary school children (aged between 6 to 12 years) with special needs, defined by psychological disorders such as asd, adhd, add, and dyslexia exclusion criteria: * children with mental retardation will be excluded

Keywords: sustained attention impulse control eye-tracking special needs computerized training
dose-dense chemotherapy versus intraperitoneal chemotherapy as first-line chemotherapy in advanced ovarian cancer

Conditions: Advanced Ovarian Cancer

Summary: to compare dose-dense chemotherapy with intraperitoneal chemotherapy in patients with advanced stage ovarian cancer.

women aged 20 and above, diagnosed with advanced stage ovarian cancer (figo stage ii\~iv), who had received debulking surgery, followed by adjuvant chemotherapy (either dose-dense or intraperitoneal) at our institution between 01 january 2006 and 31 december 2018 were included in the study. patient characteristics, any treatment related side-effects (peri-operative and post-operative complications, chemotherapy related adverse events), treatment response (complete or partial response, stable disease or progressive disease), post-treatment surveillance (disease status: disease-free, recurrence or cancer-related death) will be recorded. univariate and multivariate logistic regression analysis will be employed to evaluate the survival benefit of the two different chemotherapy methods.

Eligibility criteria:
inclusion criteria: * women with figo stage ii\~iv ovarian cancer * at least one cycle of intravenous dose-dense or intraperitoneal chemotherapy had been administered as the front-line chemotherapy. exclusion criteria: * none
study of different suturing techniques for perineal repair after delivery

Conditions: Perineal Lacerations; Episiotomy

Summary: we wish to determine wich of two standardized suturing techniques is the best for perineal repair if a perineal laceration or an episiotomy is present after vaginal birth. the participants are healthy primi para and deliver at term.

a randomised controlled trial with 400 participants was initiated in august 2004. the two suture techniques compared were both 2-layered and either continuous sutures or interrupted, inverted stitches to perineal muscles and the subcuticular layer. a polyglactin 910 multifilament thread on an atraumatic needle was used and the perineal skin was left unsutured. healthy primiparas \>36+0 weeks gestation could participate if they had a either a 2nd degree perineal laceration or an episiotomy. the trial was a double-blind and analysis was done on an intention-to-treat basis. main outcomes were pain, wound healing and patient satisfaction.

Eligibility criteria:
inclusion criteria: primipara, 2nd degree perineal laceration or episiotomy. vaginal birth of one child in occipital position terminating a pregnancy at 36 weeks or later. a soft cup used to deliver the baby was accepted. participants must be able to understand and speak danish. exclusion criteria: perineal 3rd or 4th degree injuries, post partum haemorrhage extending 1000 ml. or manual removal of placenta, former perineal wounds, foetus mortuus or delivery of a child immediately transferred to the neonatal ward, diabetes mellitus, instrumental delivery, caesarean section or gemelli.

Keywords: suture techniques
intravitreal bevacizumab for management of active progressive proliferative diabetic retinopathy (pdr)

Conditions: Diabetic Retinopathy

Summary: to evaluate the effect of intravitreal bevacizumab on the course of diabetic retinopathy in cases with the signs of active progressive pdr


Eligibility criteria:
inclusion criteria: * cases of active progressive pdr with history of scatter laser photocoagulation exclusion criteria: * history of vitrectomy

Keywords: proliferative diabetic retinopathy(pdr) pan retinal photocoagulation (prp) vitreous hemorrhage traction retinal detachment neovascularization on disc (nvd) neovascularization elsewhere (nve) fibrous proliferation on disc (fpd) fibrous proliferaiton elsewhere (fpe)
potential intervention strategy with folic acid and vitamin b12 in patients with schizophrenia

Conditions: Schizophrenia

Summary: the investigators study aims are: 1. to investigate folate, vitamin b12, and homocysteine levels in patients with schizophrenia. 2. to evaluate the relationships among folate, vitamin b12, and homocysteine levels, genetic variants of one-carbon cycle pathway, psychopathology, including positive symptoms, negative symptoms, and cognition, and metabolic abnormalities in patients with schizophrenia. 3. for patients with low folate levels, the investigators would like to conduct a 24-week double-blinded, placebo-controlled of folic acid (5 mg/d) and vitamin b12 (500 ug/d) supplementation study to know whether combination of folic acid and vitamin b12 can improve patients' psychopathology or metabolic profiles, and the effects of genetic variants in one-carbon cycle pathway on treatment response.


Eligibility criteria:
inclusion criteria: 1. age 20-65 year-old. 2. fulfill dsm-iv-tr diagnosis of schizophrenia. 3. be treated with an antipsychotic agent for at least 6 months or at a stable dose for at least 3 months. 4. patients with folate deficiency or insufficiency, and panss score at least 60 or more in the first phase screening. folate deficiency and insufficiency (low folate level) are defined as serum folate \< 6.8 nmol/l (3 ng/ml) and \<= 13.5 nmol/l (6 ng/ml), respectively. exclusion criteria: 1. medically unstable. 2. currently taking vitamin supplementation. 3. pregnancy or lactation. 4. test positive of urine drug screen 5. megaloblastic anemia due to folate deficiency; 6. patients with parkinsonism (score of \> 12 on the simpson-angus scale); 7. history of alcohol or other substances use disorder in past 3 months; 8. history of significant neurological illness; 9. creatine\>1.4 ng/dl.
effects of smartphone-based treatment for bipolar disorder - the smart bipolar

Conditions: Bipolar Disorder

Summary: the smart bipolar rct is a pragmatic rct aiming to investigate effects of smartphone-based add on treatment in large scale clinical practice (n= 200 patients).

bipolar disorder is a complex illness with a complex treatment that differs during manic, depressed, and remitted states, frequently leaving patients with decreased quality of life and impaired psychosocial function. it solutions have during recent years emerged as a possible way to optimize treatment, but the effects of digital health interventions are rarely investigated scientifically in health care services. this is an application from the entire mental health services, capital region of denmark including all psychiatric centers in the region. the smart bipolar randomized controlled trial is a pragmatic trial aiming to investigate the effects of smartphone-based add-on treatment in large-scale clinical practice (n= 200 patients). findings from the study will have a great impact on future it monitoring and treatment in bipolar disorder.

Eligibility criteria:
inclusion criteria: * all patients in cag bipolar, i.e., with a main diagnosis of bipolar disorder in the five large centers, in the mental health services, capital region of denmark (psychiatric center copenhagen, psychiatric center hilleroed, psychiatric center amager, psychiatric center glostrup and psychiatric center ballerup) exclusion criteria: * none
establishment of an ex vivo tumor collection of triple-negative breast cancers in order to validate the interest of innovative therapies and the search for predictive biomarkers of response to treatment

Conditions: Triple Negative Breast Cancer; Organoid

Summary: initially described in 2009 on lgr5 positive stem cells from intestine, organoids correspond to a 3d cell culture that preserves the organization and part of the initial function of the organ from which the cells were derived. they use the proliferation and differentiation properties of stem cells cultured in a three-dimensional matrix. these principles have been adapted to many human organs, including the breast. these culture conditions have thus allowed the establishment of cancer organoid lines that have the advantages of rapid amplification, a high rate of establishment success and unlimited proliferation potential. they are transfectable and cryopreservable. they are very close morphologically and genetically to the tumor from which they derive. very recently, the in vivo response of orthotopic xenograft models of breast cancer organoids has been correlated to the in vitro response of these same organoids. in addition, the in vitro response of various of these models to parp inhibitors was linked to the presence of the brca1/2 mutant signature, highlighting the potential of these models to predict patient response to these treatments. furthermore, one study demonstrated the value of using organoids derived from metastatic gastrointestinal tumors to predict patient response to cancer treatments (100% sensitivity, 93% specificity, 88% positive predictive value, and 100% negative predictive value.


Eligibility criteria:
inclusion criteria: * patient over 18 years of age * patient with early stage (i-iii) triple negative breast cancer who needs to have clips placed before neoadjuvant chemotherapy * patient affiliated to a social security system * proficiency in french language, * patient having signed the consent to participate in the study. exclusion criteria: * pregnant women * persons deprived of liberty or under guardianship (including curatorship) * history of any other clinically active malignancy in the last 5 years prior to inclusion
enhancing prospective thinking in early recovery

Conditions: Stimulant Use; Substance Use Disorders

Summary: the goal of this clinical trial is to use a novel virtual reality intervention to test for efficacy in reducing stimulant use and increasing abstinence, with concomitant increases in future self-identification, future time perspective, and delay-of-reward, in early recovering stimulant use disorder (stud) persons. the main question\[s\] this trial aims to answer are: * will the virtual reality (vr) intervention decrease the number of stimulant use days? * will the vr intervention produce longer abstinence periods during follow-up visits? * will the vr intervention increase stimulant drug abstinence rates? * will the vr intervention increase future self-identification? * will the vr intervention increase self-reported future time perspective? * will the vr intervention increase preference for delayed rewards in a laboratory delay discounting task on the study day? * will the vr intervention produce gains in the behavioral effects of future self-identification, future time perspective, and delayed rewards at the 30-day and 6-month follow-ups? researchers will compare the experimental and control groups to see if there are differences in the results for the questions outlined above.


Eligibility criteria:
inclusion criteria: * abstinence between ≥14 days and ≤1 year * at least 18 years old * verbal endorsement of commitment to recovery * outpatient * psychotropic drugs for sud-comorbidity * drug/alcohol abstinence ≥ 24 hours at the time of the study day visit * english comprehension exclusion criteria: * unstable medical disorders * less than 18 years old * habitual drug use * mu-opioid drugs * smell/taste disorders * unstable psychiatric conditions * extravagant/elaborate face tattoos
a study of xeloda (capecitabine) plus oxaliplatin in patients with colon cancer

Conditions: Colorectal Cancer

Summary: this 2 arm study will compare the efficacy and safety of intermittent oral xeloda plus eloxatin (oxaliplatin) with that of fluorouracil/leucovorin in patients who have had surgery for colon cancer and no previous chemotherapy. patients will be randomized to receive either 1) xelox (xeloda 1000mg/m2 po bid on days 1-15 + oxaliplatin) in 3 week cycles or 2)5-fluorouracil + leucovorin in 4 or 8 week cycles. the anticipated time on study treatment is until disease progression and the target sample size is 500+ individuals.


Eligibility criteria:
inclusion criteria: * histologically confirmed colon carcinoma, ajcc/uicc stage iii (dukes stage c) * complete tumor resection; patients operated with curative intent and with no macroscopic or microscopic evidence for remaining tumor who can be randomized to either treatment arm within 8 weeks after surgery. as this is an adjuvant trial patients should never have had any evidence of metastatic disease (including presence of tumor cells in the ascites). * have a life expectancy of at least 5 years exclusion criteria: * pregnant or lactating women * sexually active males and females (of childbearing potential) unwilling to practice contraception during the study * previous cytotoxic chemotherapy, radiotherapy or immunotherapy, for the currently treated colon cancer * patients who have not completely recovered from surgery
effect of diclofenac sodium versus calcium hydroxide as intracanal medication on the intensity of postoperative pain, bacterial load reduction and mmp-9 levels in patients with necrotic pulp.

Conditions: Necrotic Pulp; Apical Periodontitis

Summary: the aim of this study is to compare the effect of using diclofenac sodium versus calcium hydroxide as intracanal medication on intensity of postoperative pain, bacterial load reduction after root canal preparation and periapical matrix metalloproteinase 9 level (mmp-9) post-instrumentation and pre-obturation in teeth with necrotic pulp

to compare the effect of diclofenac sodium versus calcium hydroxide as intra canal medication on: - primary outcome intensity of postoperative pain will be measured using numerical rating scale (nrs) at 6, 12, 24 and 48- hours post-instrumentation and at 6, 12, 24 and 48 hours post-obturation. secondary outcome 1 bacterial load reduction will be determined by bacterial counting using agar culture technique after root canal preparation (cfu/ml). secondary outcome 2 periapical mmp-9 level will be determined post-instrumentation and pre-obturation by elisa.

Eligibility criteria:
inclusion criteria: - inclusion criteria: * patients who are free from any physical or mental handicapping condition with no underlying systemic disease. * age between 18-50 years. * males \& females. * mandibular single rooted permanent premolar teeth: * diagnosed clinically with pulp necrosis. * absence of spontaneous pain. * positive pain on percussion denoting apical periodontitis. * slight widening in the periodontal membrane space or with periapical radiolucency not exceeding 2\*2 mm radiographically. * patients' acceptance to participate in the trial. * patients who can understand pain scale and can sign the informed consent exclusion criteria: * medically compromised patients * pregnant women. * if analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively. * patients reporting bruxism or clenching. * teeth that show association with acute periapical abscess and swelling. * greater than grade i mobility or pocket depth greater than 5mm. * non-restorable teeth * teeth with vital pulp. * immature teeth. * radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.

Keywords: necrosis
microfracture vs. microfracture and bmac for osteochondral lesions of the talus

Conditions: Osteochondral Lesion of Talus

Summary: osteochondral lesions of the talus are thought to be due in large part to traumatic events or repetitive microtrauma that causes damage to both the articular cartilage and the subchondral bone. there are several treatment modalities for osteochondral lesions of the talus but there is no consensus as to which is the superior method for repair. treatment modalities are aimed at regenerating articular cartilage. microfracture is a widely accepted and utilized treatment for osteochondral lesions. this procedure results in pluripotent bone marrow stem cells filling the defect and ultimately differentiating into fibrocartilage-producing cells \[1\]. this technique has shown good results in both short- and medium-term follow-up for smaller lesions. bone marrow aspirate contains mesenchymal stem cells and growth factors with cartilage regeneration potential. bone marrow aspirate concentrate (bmac) is a treatment modality that has shown to have to potential to produce hyaline cartilage. this study aims to analyze the effect of adding bmac to the standard microfracture procedure in terms of clinical and radiographic outcomes in comparison to patients who only underwent microfracture treatment.


Eligibility criteria:
inclusion criteria: greater than 18 years of age and scheduled for surgery to treat osteochondral lesion of the talus able and willing to sign informed consent document exclusion criteria: unwilling to sign informed consent document
balance, pulmonary function, and low back pain in pregnant and non-pregnant women

Conditions: Pregnancy Related

Summary: the aims of this study were to investigate balance and pulmonary functions in pregnant and non-pregnant women and to determine their relationship with lbp.


Eligibility criteria:
inclusion criteria: * pregnant women (in the second and third trimester), non-pregnant women, aged between 18 and 40 years, volunteering to participate in the study exclusion criteria: * having a high-risk pregnancy, preeclampsia, multiple pregnancies, gestational diabetes mellitus, hypertension, any physical disability, prior history of surgery related to spine or abdominal, spinal deformity, serious neurological, rheumatologic, cardiopulmonary or psychiatric diseases, malignancy, fracture history, or those having any exercise program or sportive activity in the last 3 months for pregnant women * having any physical disability, spinal or abdominal surgery, spinal deformity, serious neurological, rheumatologic, cardiopulmonary or psychiatric diseases, malignancy, or fracture history, or those having any exercise program or sportive activity in the last 3 months for non-pregnant women