Kornimate/medical-research-clean huggingface dataset:
mutational oncology in clinical practice

Conditions: Genome Instability; Genetic Predisposition to Disease; Gene Rearrangement

Summary: the study of biological profiling is of fundamental importance in the diagnosis and treatment of many diseases, particularly oncological ones, and for this reason, the integration of molecular characterization into clinical practice becomes essential. ngs allows a high number of samples to be sequenced simultaneously, generating a great deal of genomic information in a short time and at reasonable cost. this information is of fundamental importance for the study of oncogenic drivers and gene alterations that may have a prognostic and/or predictive role in response to new molecularly targeted drugs. policlinico a. gemelli has begun a process of internal reorganization of the research infrastructure following its recognition in 2018 as an institute of hospitalization and treatment with scientific character (irccs) for its commitment to the disciplines of "personalized medicine" and "innovative biotechnology." in particular, with regard to genomics, will be equipped with a state-of-the-art technological asset that includes a fully automated process for sample preparation and the highest gene sequencing power available today. this condition makes it possible to perform extensive genomic profiling for large numbers of patients at low cost and in reasonable time.


Eligibility criteria:
- patients with neoplasm of the lung, breast, ovary, pancreas, prostate, colorectum, melanoma, gist, thyroid neoplasm, endometrium, and cholangiocarcinoma: 1. breast locally advanced or metastatic, hormone-responsive, her2-negative breast neoplasm, progressing after endocrine therapy. 2. lung metastatic disease. 3. ovary any stage of nonmucinous, non-borderline epithelial carcinoma of the ovary, fallopian tube, or primary peritoneal carcinoma. 4. pancreas metastatic disease. 5. prostate metastatic castration-resistant disease. 6. colorectum metastatic disease. 7. melanoma stage iv or stage iii undergoing surgery. 8. gist profiling of c-kit in case of metastatic disease or for patients undergoing surgery and of pdgfrα for all patients with inoperable or metastatic disease. 9. thyroid 10. endometrium 11. cholangiocarcinoma
antibacterial effect of naocl with etidronic acid in apical periodontitis treatment

Conditions: Healthy

Summary: sodium hypochlorite (naocl), the most commonly used irrigation solution during chemomechanical preparation, plays a significant role in eliminating bacteria within root canals. additionally, after preparation with different concentrations of naocl, 30% to 70% resistant bacteria were observed in the root canals. for this reason, new protocols have been developed to increase the effectiveness of naocl in chemomechanical preparation and to support disinfection within root canals. recently, etidronic acid (1-hydroxyethane 1,1-diphosphonic acid \[hedp\]), a biocompatible chelating agent, has emerged as an alternative irrigation solution. it has been suggested to combine and use this solution with naocl. this study aims to evaluate the antimicrobial effectiveness of naocl in the root canal, which is used in combination with hedp or sequentially with ethylenediaminetetraacetic acid (edta) in the final irrigation after retreatment. additionally, the effect of activation with endoactivator (ea) on microbial reduction was assessed.


Eligibility criteria:
inclusion criteria: the study included teeth from patients aged 18-65 years who had no systemic disease and had not undergone antibiotic therapy in the past three months. to ensure standardization, all the treatments were performed by a single clinician. 1. a minimum of 2 years since the initial root canal treatment 2. single rooted mandibular premolar with apical periodontitis (ap) and a canal filling within 4 mm from the apex on radiographic examination 3. the absence of pain on palpation and percussion, healthy periodontal tissues, and no mobility, 4. presence of a coronal restoration (teeth that have not retained permanent restoration over the previous root canal treatment). exclusion criteria: 1. patients who have received antibiotic therapy in the last 3 months, 2. patients with diabetes, pregnancy, immunosuppression and cardiovascular disease, 3. absence of a coronal restoration 4. presence of pain on palpation and percussion, mobility.

Keywords: bacterial reduction etidronic acid root canal irrigation sodium hypochlorite
the effect of brushing with fluoride toothpaste on dental plague control for elementary school students

Conditions: Healthy

Summary: the purpose of this study is to evaluate the effect of correct tooth cleaning and use of fluoride toothpaste after school lunch and before going to bed on primary school children's plaque reduction and tooth cleaning skills.

taking the school as a unit, the participants are children in grades three to six of elementary schools under the jurisdiction of chiayi county, with a total expected sample size of 400 people. through class teaching, the shelley method of brushing teeth is taught, and flossing instruction is added to senior grades to improve students' teeth cleaning skills. they also use fluoride toothpaste with a concentration of more than 1000ppm to clean teeth after lunch at school and before going home to go to bed. school children were tested for plaque before and after using fluoride toothpaste, collected plaque control index, filled out a self-administered tooth cleaning skills and self-efficacy questionnaire, and tracked changes in the six weeks after use. professional dentists and researchers will go to school to conduct dental plaque testing and fill out the first questionnaire for students. they will also use fluoride toothpaste after lunch at school and before going home to go to bed. together with correct tooth cleaning methods, at 6 weeks afterwards, the dental plaque test will be carried out again and the second questionnaire will be filled out. each filling in of the questionnaire will take about ten minutes.

Eligibility criteria:
inclusion criteria: * chiayi county has jurisdiction over elementary school students in grades three to six exclusion criteria: - 1. students with disability certificates. 2. school children with congenital serious oral diseases (such as cleft lip and palate). 3. children who are unable to operate the bates tooth brushing method (such as students who are still unable to complete the operation after being guided by teachers and researchers).

Keywords: children health education brushing technique dental plaque
social interaction and compassion in depression

Conditions: Depression; Couples (Persons)

Summary: the purpose of this study is to determine how a cbct® (cognitively based compassion-training) for couples affect aspects of health and especially social interactions in depressed female patients and their romantic partners. compare healthy and depressed couples during an instructed positive real-time social interaction in the laboratory. furthermore the investigators aim to examine how social behavior and psychobiological indicators of health during real-time social interaction in the laboratory might be improved through cbct® for couples.

objects: will a cbct® (cognitively based compassion-training) for couples reduce the depressive symptomatic and the partners´ burden as well as improve behavioral, endocrine, physiological and immune responses during a real time social interaction in the laboratory. do couples with a depressed female partner differ from healthy control couples in behavioral, endocrine, physiological and immune responses during a instructed positive real-time social interaction in a laboratory setting?

Eligibility criteria:
general inclusion criteria: * being in a heterosexual relationship for two years or more * agreement to participate in the study * recurrent depression (icd-10 f33.0 or f33.1, depressed females of the patient couples only) * agreement of the patient couples to be randomized into the two treatment arms * no mental disorders (healthy control group only) general exclusion criteria: * severe acute and chronic psychological ( suicidal tendency, acute affective bipolar disorders) or physical disorder (chronic diseases, severe diseases such as endocrinological, neurological, nephrological or hepatic disorders) * being pregnant * heavy smoking (more than 20 cigarettes daily) or alcohol abuse * substance related abuse and addiction * enrolling current couple therapy * enrolling current individual therapy (except of probatory phase) * enrolling current mindfulness or compassion based group training

Keywords: cbct® (cognitively based compassion-training) psychobiological evaluation real time social interaction eye-tracking heart rate variability il-6 il-1b cortisol alpha-amylase randomised controlled trial compassion empathy relationship quality interpersonal relations stress
surgical and refractive outcomes of combined glaucoma surgery

Conditions: Glaucoma; Ocular Hypertension; Filtering Surgery

Summary: the aim of the study is to examine surgical and refractive outcomes of glaucoma combined surgery in six months period of follow up

trabeculectomy and implantation of the ex-press device belong to the same group of anti-glaucoma procedures improving subconjunctival outflow. the most frequently performed glaucoma surgery of choice is still trabeculectomy, although the less invasive implantation of the ex-press device is also an effective alternative. despite the wide application of these two techniques, their impact on postoperative refraction is not entirely known. quite often, in the early postoperative period there is a decrease in visual function, which is short-term, although there are reports that it can last up to a year after surgery. it can be caused by a reduction in iop, as well as the direct effect of trabeculectomy on corneal topography, and thus on postoperative astigmatism and refractive error. the occurrence of astigmatism after trabeculectomy has been widely documented combined operations of implanting the express implant with cataract phacoemulsification differ from phacotrabeculectomy in that, they do not require cutting of the sclera, cutting the limbus and using a punch. the purpose of our research was to compare the phacotrabeculectomy and phacoemulsification combined with express device implantation in terms of incidence of postoperative astigmatism in a prospective randomized study, and to attempt to determine what factors determine its size.

Eligibility criteria:
inclusion criteria: * glaucoma with coexisting cataract graded nuclear-cortical 1 (nc1) and nuclear-cortical 2 (nc2), according to the the lens opacities classification system iii (locs iii scale), was an indication for surgery. * patients with primary open-angle glaucoma (poag), pseudoexfoliation glaucoma (pxg) and pigmentary glaucoma (pg), in which satisfactory intraocular pressure (iop \>21 mmhg) was not achieved despite maximally-tolerated topical and systemic medication, were qualified for treatment. * additional inclusion criteria were as follows: well documented progression of visual field defects, significant diurnal variations in the iop, poor patient compliance, and allergy to topical drugs. exclusion criteria: * lack of consent to participate in the study, * history of eye surgery or laser procedures within the eye, * closed or narrow angle glaucoma, * diabetes, * advanced macular degeneration * active inflammatory disease.

Keywords: glaucoma combined surgery postoperative astigmatism postsurgery refractive error
physiotherapy after botulinum toxin injection and serial casting

Conditions: Cerebral Palsy; Cerebral Palsy, Spastic

Summary: the effects of different physiotherapy programs on children with cerebral palsy who have been received botulinum toxin injection and serial casting application will be determined.

cp children who underwent botulinum toxin injection to medial gastrocnemius muscle and serial casting application in last two months will be included in the study. the effects of traditional physiotherapy and downhill backward treadmill training plus to traditional physiotherapy on muscle morphology, activity, walking, quality of life and selectivity will be determined.

Eligibility criteria:
inclusion criteria: 1. being diagnosed with cerebral palsy (cp) (hemiplegic-diplegic) 2. to have undergone botulinum toxin and serial casting interventions in the last 2 months 3. to be between 5-10 years old 4. being at the level of i-ii-iii (ambulatory or assisted ambulatory) according to gross motor function classification system 5. to have the mental competence to understand and apply assessments and exercises exclusion criteria: 1. having undergone surgery involving the lower extremity in the last 6 months 2. refusing to participate in the study 3. having other accompanying neurometabolic or orthopedic disorders

Keywords: cerebral palsy botulinum toxin serial casting physiotherapy muscle morphology
a study of comparing huachansu plus thoracic rt versus rt alone for escc

Conditions: Esophageal Squamous Cell Carcinoma

Summary: this primary objective of the trial is to study whether the local control of huachansu plus thoracic radiotherapy is better compared to thoracic radiotherapy alone for patients with esophageal squamous cell carcinoma. it's a phase ii study, 134 patients are expected to be recruited into the trial.


Eligibility criteria:
inclusion criteria: 1. joined the study voluntarily and signed informed consent form. 2. age \>75 or age 18-75 who are intolerant of or reject intravenous chemotherapy. 3. both genders. 4. esophageal squamous cell carcinoma confirmed by pathology. 5. local advanced esophageal squamous cell carcinoma (t2-4n0-1m0-1a,txn1m0-1a,txnxm1a, ajcc 6th). 6. no radiotherapy, chemotherapy or other treatments prior to enrollment. 7. ps ecog 0-2，wight loss\<30% during the latest 6 months. 8. life expectancy of more than 3 months. 9. hemoglobin（hb）≥9 g/dl,wbc≥3x109/l, neutrophils (anc )≥1.5x109/l platelet count (pt) ≥100x 109/l.hepatic function: alat and asat \< 2.5 x uln, tbil\<1.5 x uln.renal function: creatinine \< 1.5 x uln. 10. no immuno-deficiency 11. no heart diseases that need cardiac glycoside 12. use of an effective contraceptive for adults to prevent pregnancy. exclusion criteria: 1. complete esophageal obstruction. 2. deep esophageal ulcer. 3. esophageal perforation. 4. haematemesis. 5. after surgery, exploratory thoracotomy, radiotherapy, chemotherapy, or targeting therapy. 6. other malignant tumors, except for skin basal cell carcinoma, or cervical carcinoma in situ, who survived with no evidence disease for over 3 years. 7. pregnant or breast-feeding women or people during the birth-period who refused to take contraceptives. 8. drug addiction,alcoholism or aids.
awareness of gynecologists about role of physical therapy in management of polycystic ovarian syndrome

Conditions: Polycystic Ovary Syndrome

Summary: this study aimed to measure the extent of knowledge of gynecologists about the role of physical therapy in the management of pcos.

physical therapists are good communicators and also have the knowledge and skills to make a substantial impact in this field of management of polycystic ovarian syndrome. it is important for the gynecologists to have awareness about the role of physical therapy in polycystic ovarian syndrome to encourage patient to seek physical therapy help instead of suffering in silence and improve their quality of life

Eligibility criteria:
inclusion criteria: * gynecologists with more than 2 years' experience. * had managed cases of pcos. exclusion criteria: * gynecologists with less than 2 years' experience. * gynecologists who didn't deal with pcos.
intraoperative electrical impedance tomography in obese patients undergoing robotic assisted radical prostatectomy.

Conditions: Obese

Summary: the primary objective of our study will be verify a possible improvement in arterial oxygenation in the obese patient undergoing robotic-assisted radical prostatectomy if the ventilation will be guided by electrical impedance tomography rather than peripheral saturation alone.


Eligibility criteria:
inclusion criteria: * patients scheduled for laparoscopic radical prostatectomy * bmi ≥ 30 kg/m2 exclusion criteria: * surgery duration \< 2 hours * history of lung diseases
dietary perceptions and practices in chinese psoriasis patients

Conditions: Psoriasis

Summary: the influences of diet on psoriasis have been long discussed. as reported in previous publications, a majority of u.s. psoriasis population show high interest in the role of diet on their skin conditions. given the distinct traditional perceptions and lifestyles in china, the dietary beliefs and behaviors in chinese psoriasis patients would be very likely to show different patterns. nevertheless, the information of this large population is still unknown. in this regard, the investigators conduct a questionnaire-based survey, aiming to assess the dietary perceptions and behaviors of chinese psoriasis patients.

a total of 25 medical institutions all over china participated in the survey. psoriasis patients surveyed were from both outpatient and inpatient dermatology departments. researchers from each institution were trained for assisting patients to fill the questionnaire. each participant filled the online-based questionnaire anonymously in a private setting. the questionnaire consisted of 54 main questions and extended questions, concerning the profile of disease conditions, perceptions and behaviors of diet in their daily life.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old. * confirmed diagnosis of psoriasis. * duration of psoriasis ≥ 3 years. * must be able to read and understand the questionnaire. * receive a full explanation of the purpose and content of the trial before the study begins, and voluntarily sign a written consent form. exclusion criteria: * unable to read or understand the questionnaire. * other conditions deemed by the investigator to be inappropriate for this study.

Keywords: diet psoriasis perception practice
a clinical trial of acyw135 group meningococcal polysaccharide conjugate vaccine (crm197 vector) in 7 to 17 year olds

Conditions: Meningococcal Meningitis

Summary: this is a randomized, blinded, peer-controlled study. there will be 2 treatment groups, screened subjects were given study numbers in the order of enrollment and randomly assigned to the test and control groups in a 1:1 ratio. subjects were required to complete a 1-dose immunization program with 0.5 ml of vaccine in both the test and control groups, afterwards some subjects entered the immune persistence group.


Eligibility criteria:
inclusion criteria: * 7\~17 years old at the time of screening * volunteers and their legal guardians or delegates have given informed consent, have voluntarily signed an informed consent form, are able and willing to comply with the requirements of the clinical trial protocol, and are able to complete 180 days of study follow-up * willingness to discuss medical history with the investigator or physician and to allow access to all medical records related to this trial exclusion criteria: * fever on the day of vaccination, axillary temperature \>37.0°c * have a moderate or severe acute illness/infection * positive urine pregnancy test for females of childbearing age, or plan to become pregnant within 30 days after vaccination * current meningitis or history of meningitis * allergy to certain components or excipients of the drugs used in this clinical trial (mainly including: group a meningococcal podoplanoside, group c meningococcal podoplanoside, group y meningococcal podoplanoside, group w135 meningococcal podoplanoside, sucrose, mannitol, sodium chloride, dipotassium hydrogen phosphate trihydrate, potassium dihydrogen phosphate) * history of epilepsy, convulsions or seizures or history or family history of psychiatric disorders * previous severe allergic reactions due to drugs or vaccines * bleeding constitution or condition associated with prolonged bleeding, which in the opinion of the investigator makes intramuscular injection contraindicated * any meningococcal vaccine in the last 1 year * any other vaccine within 14 days * participation in other studies involving interventional studies within 28 days (\<28 days) prior to study entry and/or during study participation * other conditions that, in the judgment of the investigator, make participation in this clinical trial unsuitable

Keywords: vaccine peer controlled immunogenicity safety 7-17 years
duloxetine for acute post-mastectomy pain

Conditions: Acute Pain

Summary: the objective of this study is to evaluate the analgesic effect of oral dulexitine tablet (administered 2 h before surgery) as well as the ideal dose for acute postmastectomy pain.

patients undergoing mastectomy with axillary evacuation will be divided to four groups, placebo group: received placebo capsule duloxetine 30: received duloxetine 30 mg capsule duloxetine 60: received duloxetine 60 mg capsule duloxetine 90: received duloxetine 90 mg capsule the study medication is administered orall 2 h before surgery. primary outcome variable: the first postoperative 24 h morphine consumption secondary outcome: the vas pain score measured every 4 h in the first 24 h postoperatively.

Eligibility criteria:
inclusion criteria: * adult females scheduled for unilateral mrm with axillary evacuation for breast cancer, * american society of anesthesiologists physical status (asa) class i and ii exclusion criteria: * patients with a known allergy to duloxetine or morphine, * a history of drug or alcohol abuse, * patients with impaired kidney or liver functions, * patients with chronic pain or regularly receiving analgesics, * any psychiatric illness that would interfere with the perception and the assessment of pain. * any reason that resulted in the protocol violation.

Keywords: duloxetine mastectomy postoperative pain
hyperbaric bupivacaine versus hyperbaric prilocaine 2% for cesarean section under spinal anesthesia

Conditions: Pregnant Women; Pain; Hypotension

Summary: over the past 15 years, cesarean delivery is most commonly performed under spinal anesthesia using hyperbaric bupivacaine which provides an adequate sensory and motor block. despite effective surgical anesthesia, bupivacaine is associated with long duration motor block and dose-dependent maternal hypotension potentially harmful for the fetus. prilocaine with its new 2% hyperbaric formulation (hp), developed recently, showed rapid onset of action and faster regression of motor block compared to other local anesthetics without noteworthy side-effects when used intrathecally. the aim of this randomized, multicenter, powered clinical trial is to investigate whether hp may be an efficient alternative to hyperbaric bupivacaine for scheduled caesarean delivery under spinal anesthesia, with more rapid rehabilitation and less adverse effects. our hypothesis is that hyperbaric prilocaine offers shorter motor block and more rapid rehabilitation than bupivacaine.


Eligibility criteria:
inclusion criteria : * american society of anesthesiologists physical status (asa) \< iii * age 18-40 year * body weight \<110 kg * height between 160 and 175 cm * gestational age\>37 sa * elective cesarean delivery * singleton pregnancy * non complicated pregnancy * signed informed consent obtained prior to any study specific assessments and procedures exclusion criteria: * twin pregnancy * history of 2 cesarean section or more * diabetes and gestational diabetes * placenta praevia * congenital foetal abnormality * intrauterine growth retardation * patient in labour * membrane rupture * known allergy to local anaesthetics * standard contraindications to neuraxial block. * disagreement of the patient * neurological impairment * gestational low blood pressure * pre eclampsia and eclampsia

Keywords: cesarean delivery spinal anesthesia local anesthetics