Kornimate/medical-research-clean huggingface dataset:
observational study to assess safety and utility pattern of topical steroids

Conditions: Skin Diseases

Summary: to assess incidence of adverse drug reactions and use pattern of topical steroids among patients who are prescribed or purchase over the counter (otc) topical steroids for skin conditions in korea

* active collection of safety data, systemic and local adverse events. * in addition to spontaneous adverse event reports, patients will be asked on occurrence of adverse events upon use of topical steroids at 1 month, 2 month, and 6 month after study enrollment by e-mail or phone call * causality of adverse events will be assessed by independent two professionals * document the utility pattern of topical steroid, misuse (inappropriate indication) or overuse (in terms of application frequency or treatment duration) * collection of information related with adverse event management

Eligibility criteria:
inclusion criteria: * all patients or guardian of child purchased topical steroids in korea * informed consent to participate * willing to follow and abide by the protocol exclusion criteria: * none

Keywords: dermatologic agent
retrospective treatment pattern survey for the patient with and without history of stroke

Conditions: Hypertension

Summary: this study will compare hypertension treatment pattern of stroke patients with non-stroke patients receiving medical care from outpatient clinics at neurology specialty centers in korea. it will evaluate target bp achievement rate in patients with stroke compared to patients without stroke and investigate factors affecting bp target goal efficacy in these patients.


Eligibility criteria:
inclusion criteria: * outpatients attending neurology specialty centers, either with or without history of stroke, receiving hypertension medication exclusion criteria: * secondary hypertension patients * patients not receiving hypertension medication

Keywords: hypertension stroke neurology jnc7 2007 esh-esc guidelines survey
effects of dexmedetomidine as adjunct to pudendal block for pediatric penile surgery

Conditions: Elective Penile Surgeries; Hypospadias; Urethral Fistula or Stricture After Hypospadias Repair; Penile Curvature

Summary: caudal block is often performed to relieve postoperative pain in pediatric urological surgery. recently, pudendal block is also used in penile surgery and it has advantage because of less side effects such as transient weakness of low extremities, but limited to use in penile surgery. local anesthesia is a single shot injection, so additional analgesic drugs is required when the effect of local anesthetics are disappeared. dexmedetomidine, an alpha adrenergic agonist, is commonly used in pediatric sedation. it has analgesic effect and potentiates the effect of local anesthetics. there are many studies about the potentiation of the effect of local anesthetics when added to dexmedetomidine in adults, it has been limited in pediatrics. recent study said that local anesthetics with dexmedetomidine had prolonged duration of analgesia in caudal block, also in ilioinguinal block. thus it is expected to have a prolonged effect when investigators use dexmedetomidine in pediatrics as well as adults.


Eligibility criteria:
inclusion criteria: 1. the patients aged between 6 months and 6 years in elective penile surgeries (hypospadias, urethral fistula or stricture after hypospadias repair, penile curvature) 2. american society of anesthesiologists (asa) class i, ii exclusion criteria: 1. coagulopathy 2. allergy to local anesthetics 3. meatal island onlay proximal transverse island flap (miopti) (more than 4 h for the surgery) 4. illiteracy, foreigner

Keywords: dexmedetomidine pudendal block hypospadias
repair of infected or contaminated hernias

Conditions: Hernia

Summary: this is a prospective, multicenter, interventional, observational, open label, single arm, longitudinal evaluation of ventral incisional hernia repair using ltm in contaminated or infected sites. three interim analyses are planned to examine the incidence of surgical site events, postoperative resumption of activities and hernia recurrence.


Eligibility criteria:
inclusion criteria: * is an adult ≥18 years old. * has need of open abdominal incisional repair of a contaminated or infected site * has an estimated hernia size of \>9cm2 by physical exam exclusion criteria: * has a nidus of chronic colonization * has a systemic infection at the time of repair. * has chronic conditions: hepatic cirrhosis (w/ or w/o ascites); renal failure w/ hemo- or peritoneal dialysis; incomplete resection of malignant disease; or defined collagen disorder. * requires chronic immunosuppressive therapy, including steroids or cytotoxic agents. * is bedridden or otherwise non-ambulatory. * is asa class 4 or 5. * has a bmi \>40. * has conditions that would adversely affect subject safety, as per product labeling, including sensitivities to pork or porcine products.

Keywords: incisional hernia abdominal hernia repair ventral incisional hernia repair
evaluation of genetic abnormalities amongst calcium phosphate stone formers

Conditions: Nephrolithiasis

Summary: kidney stones continue to affect more and more people in the united states with the most recent estimate being 1 in 9 people will develop a stone in their life. while family history is a known risk factor for stone disease, it remains unclear whether this is related to learned dietary habits or a truly inheritable genetic condition. known inheritable genetic conditions linked to stone formation are uncommon, and thus, routine genetic testing is not currently recommended by any major urologic organizations. patients who form calcium phosphate predominant stones, a less common type of stone composition, tend to have alkaline urine ph which suggests that the kidneys are unable to rid the body of acid. management of such patients for stone prevention can be difficult. the iowa institute for human genomics is one of only a handful of commercial labs which offers genetic testing for stone disease. the aim of this study is to assess the rate of genetic abnormalities amongst calcium phosphate predominant stone formers with alkaline urine. to this end, the investigators plan to enroll calcium phosphate predominant stone forming patients with alkaline urine on 24 hour urine collection who obtain their health care at uihc to undergo free genetic testing via blood draw to assess for genetic abnormalities. the investigators will also collect information already available in the subject's chart to assess for other patterns between blood and urine tests and any genetic variants.


Eligibility criteria:
inclusion criteria: * any patient, aged 18-90 and not incarcerated, under the care of a urologist at uihc with known kidney stone composition including \>=60% calcium phosphate and baseline 24 hour urine ph of \>=6.3 exclusion criteria: - any patient over the age of 90 years old, incarcerated or without any evidence of calcium phosphate stone composition * no struvite component on prior stone analysis * no bacteria with urease producing organism at time of stone removal * no history or evidence of systemic acidosis * no use of acetazolamide, topiramate, zonisamide, valproic acid * stage \>=3 ckd (gfr\<60) * hepatic disease * pregnancy * history of osteoporosis

Keywords: urolithiasis calcium phosphates genetics urine
kinesio taping on chronic nonspecific low back pain

Conditions: Low Back Pain

Summary: this study propose analyze the effects of kinesio taping® in chronic nonspecific low back pain. all the subjects will be submitted to an evaluation of the painful sensation, functional performance, trunk range of motion and neuromuscular performance at three different times.


Eligibility criteria:
inclusion criteria: * female between 18 and 50 years of age with chronic nonspecific low back pain for more than three months. exclusion criteria: * serious spinal pathologies (fractures, tumors, and inflammatory pathologies such as ankylosing spondylitis); * nerve root compromise (disc herniation and spondylolisthesis with neurological compromise, spinal stenosis, and others); * fibromyalgia * corticosteroid treatment in the previous two weeks; * antiinflammatory treatment in the previous 24 hours; * contraindications to the use of kinesio taping (allergy or intolerance); * score of two or less on visual analogue scale of the first day; * pregnancy; * previous kinesio tape therapy on lumbar.
special drug use investigation for valtrex (valaciclovir) (pediatrics chickenpox)

Conditions: Varicella

Summary: the purpose of this post-marketing surveillance study is to collect and assess information on safety and efficacy of valaciclovir in pediatric patients with chickenpox


Eligibility criteria:
inclusion criteria: * pediatric patients with chickenpox (aged less than 15 years old). exclusion criteria: * patients with a history of hypersensitivity to the ingredients of valaciclovir or acyclovir.
study of docosahexanoic acid in patients with cystic fibrosis (cf)

Conditions: Cystic Fibrosis

Summary: patients with cystic fibrosis have increased oxidative stress and impaired antioxidant systems. under certain conditions, docosahexaenoic acid (dha) intake may have a favorable role in reducing redox status. in this randomized, double-blind, cross-over study, dha (pro-mind) and placebo (sunflower oil) capsules, will be given, daily to 10 patients, 5 mg/kg for 2 weeks then 10 mg/kg for the next 2 weeks. biomarkers of lipid peroxidation and vitamin e levels will be measured. plasma and platelet lipid compositions will be determined.


Eligibility criteria:
inclusion criteria: * male with confirmed diagnosis of cystic fibrosis with a sweat chloride \> 60 mmol/l and a pancreatic insufficiency. * subjects will be aged between 6 and 18 years and be prepubescent, or aged between 18 and 30 years * body weight \> 26 kg * stable cf disease as judged by the investigator. * subjects must have an forced expiratory volume at one second \> 40 % of predicted normal for age, sex and height at the screening visit. * subjects should not have enteral or parenteral nutrition. * no periodic iv lipidic emulsion administration. subjects must not consume food supplements rich in omega-3 on a regular basis. exclusion criteria: * subjects with cirrhosis and portal hypertension. * subjects with cystic fibrosis related diabetes. * concomitant participation in another clinical study. * known allergy or intolerance to the active principle. * subjects with major blood coagulation anomalies, patients under anticoagulants or aspirin (long term therapy). * subjects on a transplant waiting list.
cpap for osa on myocardial salvage after ppci for stemi patients

Conditions: Obstructive Sleep Apnea; ST Elevation Myocardial Infarction

Summary: the aim of this randomized controlled trial to investigate the effects of cpap treatment on myocardial salvage index and clinical outcomes at 3 months in patients with osa and st-segment elevation myocardial infarction (stemi) after primary percutaneous coronary intervention (ppci).


Eligibility criteria:
inclusion criteria: 1. 18 to 80 years old 2. first-time stemi 3. successful ppci (≥1 coronary artery) within 24h after symptom onset 4. moderate to severe osa (ahi≥15) 5. written informed consent exclusion criteria: 1. prior myocardial infarction 2. prior myocardial revascularization (pci or cabg) 3. cardiogenic shock (mean arterial pressure \<60mmhg), severe heart failure (killip≥3) 4. lm or multivessel disease indicated for cabg 5. history of stroke 6. severe insomnia, chronic sleep deprivation, abnormal circadian rhythm (sleep \<4h/night) 7. severe copd: fev1/fvc \<70% or fev1 \<50% predicted value (within 4 weeks) 8. predominantly central sleep apnea (≥25% central events or central ahi ≥10/h) 9. previous or current use of cpap 10. severe comorbidities: eg. malignancy (life expectancy \<2 years) 11. known or planned pregnancy 12. known contraindication to cmr 13. patients with contraindication to cpap or who cannot tolerate it 14. participation in other clinical trial in recent 3 months 15. any condition that in the opinion of investigator that may jeopardize patient compliance, eg. significant memory, perceptual, or behavioral disorder, depression, severe alcohol consumption, or a history of noncompliance

Keywords: continuous positive airway pressure myocardial salvage obstructive sleep apnea st elevation myocardial infarction
proton pump inhibitors in the prevention of iron reaccumulation in patient with hereditary hemochromatosis

Conditions: Hemochromatosis

Summary: hereditary hemochromatosis (hh) is a genetic disorder of iron metabolism, resulting in excessive iron overload causing damage of different important organs like heart, liver, pancreas and joints. complications and symptoms can regress by intensive treatment reducing the iron overload stores.different genes have been identified playing a role in the pathophysiology of iron overload. a clinically important hfe gene mutation is the c282y, located on chromosome 6. phlebotomy is currently the standard therapy which consists of removal of 500 ml whole blood weekly, representing a loss of 250 mg iron. in naive patients between 20 to 100 phlebotomies are required to reduce the serum ferritine levels to 50 μg/l. thereafter, a lifelong maintenance therapy of 3 to 6 phlebotomies yearly is needed. for absorption, dietary iron ( 70%) is reduced by gastric acid form the ferric (fe3+) to the ferrous form (fe2+). recently, in an observational open study, hutchinson et al. found that hh patients treated with proton pump inhibitors (ppi) needed fewer phlebotomies, resulting in a drop of 2.5 (sem 0.25) to 0.5 (sem 0.25) liter per year. research question: the primary objective is to determine the effectiveness and cost effectiveness of ppi's compared to standard phlebotomy therapy in the prevention of iron overload in hh patients. multi-center trial in two hospitals in the south of limburg (atrium medical center, maastricht university medical center ) and hospital in belgium (university hospital gasthuisberg). the study will be conducted in randomised double blind manner. the follow up will be one year. patients are randomized either for the group receiving a ppi or a placebo. every 2 month the ferritin level is measured and decided if the patient need a phlebotomy (ferritin \>100 µg/l).


Eligibility criteria:
inclusion criteria: * patients with hereditary hemochromatosis (hh), homozygous for c282y, currently treated with phlebotomy as maintenance therapy for at least 12 months with ≥ 3 phlebotomies per year. * ferritin level between 50-100 μg/l at start of the inclusion. * age: 18 years- 60 years and weight \> 50 kg. exclusion criteria: * patients receiving other therapies such as chelating therapy or forced dietary regimen. * patients younger than 18 years. * hh patients with excessive overweight (bmi \> 35). * patients who are mentally incapacitated. * women being pregnant or expecting/ planning to become pregnant during the one year period of the study. * patients with a malignancy. * patients already on ppi treatment. * patients who experienced side effects of ppi's.
optimal exercise frequency to reduce liver fat in centrally obese adults with non-alcoholic fatty liver disease

Conditions: Non-Alcoholic Fatty Liver Disease; Obesity

Summary: this study aims to examine the comparative effectiveness of different exercise frequencies (once-a-week vs. thrice-a-week) for reducing liver fat in centrally obese adults with non-alcoholic fatty liver disease (nafld), with weekly exercise volumes aligned with the world health organization's physical activity recommendations.

this study is a three-arm randomized controlled trial. participants will be randomly allocated to the once-a-week exercise group, thrice-a-week exercise group, or usual care control group. the exercise intervention groups will receive once-a-week or thrice-a-week exercise (with matched weekly exercise volumes). the usual care control group will receive general health education. all interventions will last for 4 months. outcome measures will be examined at baseline, 4 months (post-intervention), and 10 months (6-month follow-up).

Eligibility criteria:
inclusion criteria: 1. cantonese, mandarin, or english speaking chinese; 2. aged 18-69; 3. male or female; 4. centrally obese according to the asian-specific cut-off (waist circumference ≥90 cm for males; ≥80 cm for females) and with bmi ≥23; 5. with nafld (defined as \>5% intrahepatic triglycerides assessed by 1h-mrs); 6. willing to participate in exercise training to improve nafld. exclusion criteria: 1. regular exercise training (\>3 sessions of \>60 min of moderate-intensity exercise training weekly) in the past 6 months; 2. medical history of cardiovascular disease, chronic pulmonary or kidney disease, heart failure, cancer, and/or liver disease except nafld; 3. somatic conditions that limit exercise participation (e.g., limb loss); 4. impaired mobility due to chronic disease (e.g., chronic arthritis/osteoarthritis, neurological, musculoskeletal, and autoimmune diseases); 5. daily smoking habit; 6. excess alcohol consumption (daily ≥20 g of alcohol for men and ≥10 g for women) in the past 1 year; 7. consumption of certain drugs (e.g., tamoxifen and estrogen) known to be secondary causes of steatosis; 8. surgery, therapy, or medication for obesity or weight loss in the past 6 months (e.g., gastric bypass, gastric band, sleeve gastrectomy, gastric reduction duodenal switch, or dietitian-prescribed dietary program); 9. physical changes that considerably affect body composition and weight (e.g., anorexia nervosa, bulimia nervosa, prolonged gastrointestinal and digestive disorders) during the study period.

Keywords: non-alcoholic fatty liver disease overweight central obesity obesity adults aerobic exercise exercise frequency
prevalence and risk factors of helicobacter pylori infection in children and young adults

Conditions: Helicobacter Pylori Infection

Summary: helicobacter pylori is a gram-negative bacterium that resides in the stomach and can cause inflammation leading to long-term effects, such as gastric ulcers, cancer, and lymphoma of the stomach mucosal linings previous research and analysis of h. pylori prevalence in populations have examined common risk factors that increase the likelihood of acquiring the bacteria. some of the most commonly identified risk factors across various studies in different geographic populations are larger family size, less education, lower socioeconomic status, less frequent hygiene practices, and lower sanitation with specific emphasis on sources of water and defecation. aim of the work: studying prevalence of helicobacter pylori infection and its related risk factors in children and young adults in sohag governorate.


Eligibility criteria:
inclusion criteria: * children and young adults (between 2 to 25 years old) exclusion criteria: * children below 2 years old * adults more than 25 years old

Keywords: helicobacter pylori dyspepsia children young adults prevalence peptic ulcer risk factors
investigation of the cerebrospinal fluid and further tissue samples for biomarker indicating spinal ischemia and organ failure in patients with thoracoabdominal aortic aneurysm

Conditions: Thoracoabdominal Aortic Aneurysm

Summary: patients with a thoracoabdominal aortic aneurysm in need of an endovascular or open operative restructuring will be asked to participate in this study. after obtaining written consent a central venous catheter and a liquor drainage will be routinely placed during surgery. the catheter and the drainage will stay in the patients for at least 72 hours postoperatively. in total, nine measurements of the liquor and serum will be performed within a week in order to determine the following parameters: neuropeptide p, neuropeptide y, neurofilament triplet protein (nfl), s100b, glial fibrillary protein (gfap), lactate, glucose, or oxygen.

patients with complex aortic diseases receiving an operative treatment are under risk of spinal cord damage due to insufficient blood circulation of the spinal cord during surgery. the risk depends on comorbidities, extent of surgery, and the perioperative management. despite an adequate preoperative imaging, assessment of the blood circulation of the spinal cord during endovascular or open operative restructuring is struggling. beside the monitoring possibilities of the spinal cord functions during surgery, insufficient approaches regarding early detection of spinal ischemia by using laboratory parameters exist. several biomarker, e.g. neuropeptide p, neuropeptide y, neurofilament triplet protein (nfl), s100b, glial fibrillary protein (gfap), lactate, glucose, or oxygen, will be evaluated singularly or as a bundle of markers in small patient groups. surgeries of thoracoabdominal aortic aneurysms are associated with high risks despite already existing high standardized procedures (cowan et al. 2003). the major complications are cardiovascular, renal, pulmonary, gastrointestinal complications, and ischemias of the spinal cord. especially, the ischemia of the spinal cord is a feared complication caused by the irreversibility and the small time frame. during the study samples of liquor and tissues (serum, urine) will be drawn pre-, peri- and postoperatively. patients will receive a routinely placed liquor drainage due to the temporal duration in surgery. the liquor drainage stays in the patient also in the early postoperative phase. hence, the patient will not be bothered with additional examinations. additionally, biomaterial (blood) will be drawn routinely and used for the biomarker measurement as well as biobanking.

Eligibility criteria:
inclusion criteria: * presence of thoracoabdominal aortic aneurysm * endovascular or open operative restructuring * age\>18 years * given written consent * subjects, who are mentally and legally capable to understand the scope of the trial and comply with the protocol exclusion criteria: * local skin infection (cutaneous fungus, acne) * pregnant or lactating females * parallel participation in another clinical trial * incarcerated subjects * subjects, who are in an interdependency with the sponsor or investigator