Kornimate/medical-research-clean huggingface dataset:
echothiophate iodide for the prevention of progression of myopia

Conditions: Myopia

Summary: the purpose of this study is to test the hypothesis that myopia progression can be slowed or prevented by low dose echothiophate iodide.

this pilot study is designed to establish proof of concept of a method to either slow or stop the progression of myopia in children between the ages of 8 and 15 years by using echothiophate iodide eye drops to alter the relationship between focusing (accommodation), eye alignment, and peripheral blurring. echothiophate iodide 0.03% eye drops have been used for years for the treatment of accommodative esotropia in children. a prospective double blind randomized study of 33 children with active development of myopia will be divided into a treatment group of 22 and a control group of 11. they will be treated for 18 weeks with four planned visits at 6 week intervals. the progression of myopia will be measured by a determination of the length of the eye (axial length measured by the iol master) and cycloplegic refractions. influencing factors such as corneal changes, lens changes and macular choroidal thickness will be monitored for any significance. if successful, a larger and longer study to slow the rate of myopia with echothiophate iodide will be done in order to decrease the world's incidence of myopia currently at 25-33% in western countries and 85% in asian countries. this would also reduce the financial burden of glasses and contact lenses as well as decrease the incidence of pathological eye disease due to high myopia.

Eligibility criteria:
inclusion criteria: * healthy children between 8-15 years of age * documentation of progression of myopia within the 12 months prior to enrollment * written informed consent/assent for the study exclusion criteria: * any history of retinopathy of prematurity, glaucoma, cataracts, corneal disease, uveitis, manifest strabismus, nystagmus or ocular trauma * any history of unstable asthma, diabetes, or juvenile idiopathic arthritis asthma must be stable for three months prior to enrollment if utilizing oral or inhaled steroids * systemic muscarinic agents, steroids, or anticholinesterase agents. * benzalkonium chloride preservative allergy. * astigmatism \>0.75d * anisometropia \>1.50d * pregnancy or a positive pregnancy test at the screening visit.
the effect of infliximab on sperm quality

Conditions: Crohn's Disease; Ulcerative Colitis

Summary: background: the treatment of inflammatory bowel diseases (ibd) is based mainly on 3 compounds: 1- 5 aminosalysilates . 2- immunomodulators (azathioprines). 3- biologic therapies (infliximab, adalimumab) . there are no established data in the literature whether these therapies effects sperm quality. given that a large number of the patients are young men in the reproductive stage of their lives , it of importance to investigate these effect. aim: to investigate the effect of chronic treatment of any of the three therapy mentioned above, on sperm quality .


Eligibility criteria:
inclusion criteria: * male above the age of 18 * capable of giving informed consent * diagnosed with ibd at least 3 months * patients that are going to start a treatment with on of the following groups: 5asa, azathioprines, infliximab or adalimumab * patients that are treated with therapies mentioned in article 4 for at least 3 months exclusion criteria: * male younger than 18
long-term safety of symbicort in asthmatic children - sapling

Conditions: Asthma

Summary: the purpose of this study is to assess the safety of symbicort compared to pulmicort in asthmatic children aged 6 to 11 years


Eligibility criteria:
inclusion criteria: * at least 6 and maximally 11 years of age * diagnosis of asthma * baseline lung function tests as determined by protocol and required and received daily treatment with inhaled corticosteroids for at least 4 weeks prior to study start exclusion criteria: * has required treatment with any non-inhaled corticosteroids within the previous 4 weeks, has sensitivity to drugs specified in the protocol or requires treatment with beta-blockers * has had cancer in the previous 5 years or has a significant disease that may put the patient at risk in this study

Keywords: asthma children symbicort budesonide/formoterol pulmicort budesonide
switch of androidaps to commercially available aid systems

Conditions: Diabetes Mellitus, Type 1

Summary: the aim of the study was to investigate the switch between open-source automated insulin delivery system (os-aid) - androidaps (aaps) and commercially available aid systems - control-iq (ciq) and minimed 780g (780g) in extended follow-up study.


Eligibility criteria:
inclusion criteria: * type 1 diabetes diagnosed \>2 years * ≥ 18 years old * written informed consent prior to starting study related activity * previous user of androidaps at least for 3 months exclusion criteria: * nonadherence to the current treatment regimen * lactation * pregnancy * intending to become pregnant during study * concomitant therapy influencing glucose metabolism

Keywords: insulin pump closed-loop hybrid system continuous glucose monitoring automated insulin delivery
effect of a multistrain probiotic on cold symptoms in healthy patients with an history of upper airways infection

Conditions: Cold Symptom

Summary: the study is a double-blind randomized clinical trial which aims to evaluate the efficacy of a multi strain probiotic in human adults in controlling and improving cold symptoms and inflammatory response

adult subjects (age 18-44) with a history of upper airways infection, will be assigned to placebo or probiotic groups and take either placebo or probiotic dietary intervention for 12 weeks. after that, a 6 weeks follow-up. the answers at: common cold questionnarie (ccq), wisconsin upper respiratory symptoms survey-21 (wurss-21) and quality of life score (sf-36) will be compared in the two groups. in addition, serological markers (blood count, lymphocyte subpopulation (b, t, t4, t8, nk), ifn-γ and il-10 levels) will be evaluated over a 18 week period.

Eligibility criteria:
inclusion criteria: people who: * are willing and capable of joining the study * are willing of not varying their routine (lifestyle, physical activity..) during the study * are willing of not varying their diet during the study * are willing of using only the testing product during the study * are willing of not using products that may interfere with the testing product * have not recently joined similar studies * have signed informed consent exclusion criteria: subjects: * not filling the inclusion criteria * with suspected or confirmed sensibility to one or more product component * with chronic diseases (cardiovascular congenital diseases, hepatic diseases, renal disease, immunodeficiency) * undergoing antibiotic/pharmacological treatment * with other concomitant disease (infective, respiratory, gastrointestinal, immune) * who underwent an immunomodulating treatment in the past 4 weeks * who underwent an immunosuppressant therapy in the past 3 months * with severe disease ongoing * who abuse of alcohol and/or drugs * who are considered not eligible by the investigator * not able to communicate due to language barriers, mental issues or cerebral functioning impairment

Keywords: cold cold symptoms probiotics
erbium, chromium: yttrium, scandium, gallium, garnet (er,cr:ysgg) laser in root canal disinfection

Conditions: Endodontic Disease; Root Canal Infection

Summary: the purpose of this study is to develop a protocol for biofilms disinfection with a fda cleared, clinically approved and commercially available er,cr:ysgg laser treatments. this protocol will be testing local single topical application of lasers within the canal system in patients going through routine endodontic treatment, evaluate its potential as anti-biofilm treatment and compare it to other currently used antibacterial protocols.

after being informed about the study and its potential risk, for all patients giving written informed consent we will screen potential participants by inclusion and exclusion criteria; clinical assessment, obtain radiographs, medical history/medications and documents to determine eligibility for study entry. participants who meet the eligibility requirements will be randomized in a 1:1 ratio to group 1: standard of care irrigation protocol "sodium hypochlorite (naocl)", group 2: er,cr:ysgg laser + standard of care irrigation protocol (naocl).

Eligibility criteria:
inclusion criteria: * provision of signed and dated informed consent form. * stated willingness to comply with all study procedures and availability for the duration of the study. * male or female (gender is not an inclusion or exclusion criteria), aged 18 years old or above. * in good general health as evidenced by medical history or non-contributory medical history (patient can be seen for regular dental appointment in penn dental medicine; american society of anesthesiologists (asa) classes i and ii). * radiographic presence of periapical radiolucency. * negative response to thermal sensitivity testing (difluorochloromethane at -50 °c, endo-ice, coltène/whaledent inc., cuyahoga falls, ohio) or electric pulp testing. * enough tooth structure for adequate isolation with rubber dam. * no history of previous endodontic treatment on the tooth. * teeth with single canal, 1 distal canal of lower molar, 1 palatal canal of upper molar. exclusion criteria: * patients who report they are pregnant. * teeth affected by dental trauma. * periodontal changes (pockets 3 mm, mobility i or gingival edema). * radiographic presence of resorptive processes. * per the investigator's discretion, unable or unlikely to comply with study procedure. * presence of any condition which, in the opinion of the investigator, makes participation in the study not in the individual's best interest.

Keywords: root canal irrigants lasers
prognostic factor research of sensory profiles in development of central sensitization

Conditions: Sensory Profiles; Central Sensitisation; Low Back Pain; Nociplastic Pain

Summary: a longitudinal observational cohort study to investigate the value of prognostic factors, here sensory profiles , and others, in the development of central sensitization in the low back pain population. a type 2 prognostic factor research following the progress framework. sensory profiles are identified a prognostic factors which can predict the development of central sensitization in the low back pain population.

after performing an univariable linear regression analyses the regression model predicts the dependent variable, central sensitization, significantly, and the models are significant prediction factors of the development of central sensitization. in unadjusted analyses, all four sensory profiles were significantly associated with the development of central sensitization (p\<0.001). after adjusting for pain, disability, age, and duration of low back pain, baseline sensory profiles remained significant predictors of central sensitization. on the other hand, all other predictor variables did not contribute to the prediction of central sensitization.

Eligibility criteria:
inclusion criteria: * acute low back pain (\< 6 weeks) * with or without radiating pain * aged 18 to 60 years * a pain-free episode for at least 3 months before the onset of their current back pain * read and understand the dutch language. exclusion criteria: * previous lumbar spinal surgery * lumbar radicular syndrome * specific cause of low back pain * lumbar spinal stenosis * current malignancy * spondyloarthropathy * osteoporosis * spondylolisthesis * major trauma * infection * systemic disease.

Keywords: prognostic factors research sensory profiles central sensitisation low back pain nociplastic pain
a case series on incidentally detected gallbladder malignancy

Conditions: Gallbladder Malignant Neoplasm

Summary: a retrospective analysis of data, using the hospital records of all the patients who underwent cholecystectomy for benign conditions at osmania general hospital in a year (2019).

a retrospective analysis of hospital records of patients who underwent cholecystectomy in a year duration (2019) for any benign condition, diagnosed and confirmed histopathologically as gallbladder malignancy. there are a total of one hundred and eighty patients who underwent cholecystectomy at our hospital (osmania general hospital) in 2019, out of which seven patients' histopathological diagnosis was gall bladder malignancy. we reviewed all the case's history, cross-checked the histopathological slides, and confirmed the diagnosis. to avoid the bias of covid-19 pandemic in surgical practice we confined the patient records to the pre-pandemic period of one-year duration (2019). a total of 180 patients underwent cholecystectomy for various benign conditions in one year, out of which seven patients confirmed histopathologically with gallbladder malignancy. total no of patients : 180 diagnosed with malignancy : 7 percentage 3.8% among these seven, three patients converted from laparoscopic to open procedure for difficulty with resection, two patients are posted for surgery considering empyema of gall bladder preoperatively, one patient in view of gall bladder perforation, and for two patients preoperative diagnosis was gall bladder polyp. converted from lap to open: 3 pre-op gb polyp : 2 perforated gb : 1 empyema gb : 2 only one patient is 40 years old and others are more than 50 years, and two of them are males. total : 7 100% males : 2 28.5% females : 5 71.5% out of a total of 180 patients who underwent cholecystectomy, 117 are females and 63 are males total : 180 males : 63 females : 117 out of 180, the age distribution is as follows age. percentage 20 - 29 0 30 - 39 0 40 - 49 0.005 \>50. 99.99 it implies that the malignancy rate increases with an increase in the patient's age more than 50years and also with gender (females \> males).

Eligibility criteria:
inclusion criteria: all patients who underwent cholecystectomy for benign conditions - exclusion criteria: all those who already diagnosed with gallbladder malignancy -

Keywords: gallbladder, polyp gallstones malignancy perforation
early childhood caries prevention at a pediatric clinic

Conditions: Dental Caries

Summary: this purpose of this study was to evaluate effectiveness of a risk-based dental caries prevention program conducted by dental personnel at an urban pediatric primary care clinic serving largely low-income residents of baltimore, maryland, and to appraise this program as a model for similar urban pediatric settings.

a demonstration caries prevention trial lasting 26 months was conducted with a total of 219 children aged 6 to 27 months of age. the "prevention" group consisting of children 6-15 months of age at their initial visit were compared at the end of the trial with a "comparison" group at their initial visit. the comparison group was 12 months older than the enrollment age of the prevention group (18-27 months) and had not received previous routine professional dental care. interventions were dental examination and periodic recalls, caries-risk assessments, monitoring of oral mutans streptococci (ms) levels, application of 5.0% sodium fluoride varnish to teeth, dental health counseling to care-givers, referral for dental treatment if indicated and periodic recalls. outcome measures were: 1) number of decayed, missing, filled primary tooth surfaces, 2) number of pre-carious lesions, 3) counts of oral ms and 3) care-giver responses to a questionnaire about the child's diet and home care. prevention group children at the last recall experienced fewer mean carious dental surfaces (0.1 vs. 1.29, p\<0.014) and over 8-fold less ms (p\<0.013) than comparison group subjects at the initial visit. the number of precarious lesions, however, were not significantly different. in the absence of carious or precarious lesions, oral levels of ms was a reliable indicator of caries risk status, particularly for low risk subjects (sensitivity, 0.64; specificity, 0.98). caregiver reports of dietary practices and presence or absence of visible dental plaque also served as caries-risk determinants.

Eligibility criteria:
inclusion criteria: * children in good health who were dentate and 6-27 months * a signed informed consent exclusion criteria: * antibiotic usage within the previous 14 days * oral topical fluoride administration within the previous 7 days * previous routine professional dental care

Keywords: dental caries early childhood caries caries prevention infants
immobilization in reverse shoulder prosthesis

Conditions: Rotator Cuff Tear Arthropathy

Summary: reverse shoulder prostheses are the treatment of choice in elderly patients with rotator cuff arthropathy. traditionally these patients have been immobilized for 3 weeks in the immediate postoperative period in order to have good pain control. however, there are no studies that determine the most appropriate period of immobilization. in fact, patients undergoing this type of surgery begin rehabilitation exercises within 24 hours of surgery without experiencing increased pain or requiring specific analgesic treatment. there is a demand in the elderly to limit immobilization time as much as possible, as some live alone and need to be self-sufficient and others have dependents. it would be good to know if it is really necessary to make an immobilization in these patients undergoing this type of surgery.


Eligibility criteria:
inclusion criteria: * patients undergoing primary surgery of inverted prosthesis for rotator cuff arthropathy. * age between 65-85 a. * without inflammatory pathologies (rheumatoid arthritis, psoriatic arthritis, ...) * acceptance to be part of the study. exclusion criteria: * prosthetic surgery prior to the affected limb. * other indications of reverse prosthesis other than rotator cuff arthropathies (acute fractures, sequelae fractures, tumor surgery, prosthetic revision surgeries). * no acceptance to participate in the study.
assessments and interventions for hand neuropathy in dm

Conditions: Diabetes Mellitus; Neuropathy, Diabetic

Summary: this study is to investigate the effects of task-based biofeedback training compared with home-based programs on sensorimotor function and quality of life for diabetic patients with neuropathic hands. the investigators hypothesize that the task-based biofeedback training might have significant effectiveness for restoration of sensory function, precision pinch performance, hand dexterity and life quality for patients with diabetic neuropathy.

hand tendon gliding exercises allow both the flexor digitorum profundus and superficialis tendons of hands to achieve the greatest range of motion. thus, in conjunction with resistive exercises for diabetic hands, such exercises are considered an appropriate home-based training method that has positive effects on various diabetic hand problems in terms of regaining smooth tendon excursion, preventing joint contracture, and reducing intrinsic muscle tightness. different from the biomechanical approach to deal with hand problems, a biofeedback system can be used to provide real-time information on improper movements during task-based training intended to enhance either performance quality or accuracy. this study aims to analyze the difference in treatment effects between a computerized evaluation and a re-education biofeedback system that provides interactive sensorimotor information to shape the optimized coordinated pinch pattern of a hand and a home-based tendon gliding exercise program in conjunction with resistive exercise with weekly supervision on sensorimotor function and quality of life for diabetic patients. the investigators hypothesize the task-based biofeedback training using the biofeedback training system could have significant effectiveness for restoration of sensory function, precision pinch performance, hand dexterity and life quality for patients with diabetic neuropathy.

Eligibility criteria:
inclusion criteria:(for training groups) * with clinically-defined type ii dm who were diagnosed based on the 1997 american diabetes association criteria * impaired in terms of force modulation in precision pinch performance as detected using the phua test are referred from outpatients from the department of family medicine in a medical center in southern taiwan exclusion criteria:(for training groups and healthy control group) * diagnosed neuro-musculoskeletal disorders * traumatic nerve injuries of the upper limbs * trauma to the hand or congenital anomalies of the wrist and hand * skin infections or disease of the hands * cognitive deficits * aged less than 20 years old
early detection of barrett's esophagus through deep image retrieval

Conditions: Barrett Esophagus

Summary: barrett's oesophagus is a condition in which the area between the oesophagus and stomach no longer closes, allowing acidic contents of the stomach to enter the oesophagus and damage the lining. the project aims to assist clinicians by offering informed biopsy process, in which the system presents the operator with clinical outcomes of patients with visually similar gi tracts. the project goal is to assess the use of artificial intelligence-based similarity detection systems to better inform biopsy placement, increasing the reliability of bi-yearly inspections.

the project intention is to acquire secondary endoscopy captured data from clinicians to create a sufficient dataset to train a learning system to achieve the stated objective. the data required will feature footage (images/videos) from inside the oesophagus. the preferred data would contain associated diagnosis notes and description, however, data without diagnosis can still be used. all data can and will be anonymised, as personal information will not be useful in this work. the data will be labelled by either researchers, or professional clinicians and prepared ready to feed into a chosen learning ai system. through an iterative learning process, the chosen ai system will learn to discriminate between severity of barrett's oesophagus and output optimal biopsy target.

Eligibility criteria:
inclusion criteria: * adult * attending southmead hospital for on ogd * has capacity * initially any indication, later patients with known barrett's oesophagus exclusion criteria: * children (\<18) * patients without capacity * urgent and emergency procedures * limited english