Kornimate/medical-research-clean huggingface dataset:
electro-acupuncture for gait and balance in parkinson's disease

Conditions: Parkinson's Disease

Summary: gait and balance disorders, key contributors to fall and poor quality of life, represent a major therapeutic challenge in parkinson's disease (pd). despite the widespread use of acupuncture in recent years in pd, its efficacy remains unclear, largely due to methodological flaws and lack of high quality studies using objective outcome measures. in a patient and assessor-blind pilot study, investigators objectively assess the efficacy of electroacupuncture (ea) for gait and balance disorders using body-worn sensor technology in patients with pd.

in this study, investigators employee objective innovative body-worn sensor technologies to assess potential mobility-associated outcomes of pd. investigators compare acute changes in gait and balance that occurred after repeated administration of two interventions: a specific real ea and a sham ea. the design of the experiments uses a control that accounts for both placebo and possible some active components of a generalized needle-insertion-based procedure. by using a sham control, the investigators were able to more fully test whether the specific ea intervention could lead to changes in objective gait and balance parameters, or subjective self-reported improvements that are beyond placebo induced effects and the natural course of the disease.

Eligibility criteria:
inclusion criteria: 1. community-dwelling men or women ages 55 years or older with diagnosis of pd; 2. patients who have the ability to walk 20meters without walking assistance; and 3. patients who are stable without anti-pd medication(s) change for at least 1 month. the pd diagnosis was made by movement disorder specialists based on the uk brain bank criteria and supported by datscan (ioflupane i 123 injection) when possible. exclusion criteria: 1. patients who have received previous acupuncture; 2. patients who have had dbs; 3. patients with any clinically significant medical condition, psychiatric condition, drug or alcohol abuse, or laboratory abnormality that would, in the judgment of the investigators, interfere with the ability to participate in the study; and 4. patients with non-pd related gait disorders.

Keywords: electroacupuncture body worn sensor gait balance
delirium, intraoperative cerebral perfusion and eeg abnormalities after total hip arthroplasty

Conditions: Delirium; Hip Arthroplasty; Elderly

Summary: the overall objective of this study is to test for perturbations in intraoperative electroencephalogram (eeg) , cerebral blood flow (cbf), cerebral metabolic rate of oxygen consumption (cmro2), oxygen extraction fraction (oef), and serum and cerebral spinal fluid biomarkers associated with delirium in high risk population having elective hip arthroplasty at penn presbyterian medical center (ppmc).

all prospective patients will be given a copy of the informed consent which explains the details and responsibilities of the study. each patient will have a preoperative baseline 3d-cam and moca to document preoperative cognitive function and possible criteria for exclusion. 1. the 3d -confusion assessment method (cam) test is a clinician evaluation and algorithm for the binary determination of presence or absence of delirium. 2. montreal confusion assessment (moca) - to be given preoperatively to determine if element of pre-existing cognitive impairment intraoperatively each patient will have a nir optode patch placed to measure intraoperative cerebral blood flow and oxygen extraction fraction and cerebral metabolic rate of oxygen consumption. a non-invasive frontal eeg patch will be placed prior to or at the start of anesthesia. anesthetic depth will be measured using the sedline® by masimo. continuous raw eeg, spectral edge, compressed spectral analysis and percentage suppressed will be recorded from the sedline® monitor. the investigators will be drawing blood from patients who agree to participate in the study. preoperative blood sampling will be done while the investigators place the intravenous line, or if present, from an arterial line. if a spinal anesthetic is being used, 5 ml of cerebral spinal fluid (csf) will be collected at the time of dural puncture prior to the administration of the neuraxial blockade. members of the research team will administer 3d-cam testing on post-operative days 1 and 2.

Eligibility criteria:
inclusion criteria: 1. patients 65 years of age and over scheduled for elective total joint arthroplasty 2. mentally competent and able to give consent for enrollment in the study 3. patients at any age with a pre-existing diagnosis of dementia or acquired cognitive deficit. consented by legally authorized representative (lar). exclusion criteria: 1. patients currently delirious 2. acute neurological disease like stroke or brain tumor 3. current alcohol or substance abuse at risk of postoperative withdrawal

Keywords: serum biomarkers cerebral blood flow modified blessed dementia rating scale confusion assessment method delirium rating scale-98
effect of qigong on balance, fall efficacy, wellbeing of people with stroke in hong kong

Conditions: Stroke

Summary: the purpose of this study is to compare the effects of qigong practice with fitness exercise on balance, fall-efficacy, physical functions, psychological wellbeing and quality of life of stroke survivors.

participants: a total of 58 stroke survivors 3 months after the current stroke will be recruited. methodology: an assessor-blinded, randomized controlled trial will be conducted. stroke survivors will be included in the study if they meet the inclusion criteria. selected patients will be randomly allocated into either the experimental group or the control group. participants allocated in the experimental group will receive qigong training while this qigong training will be replaced by a home fitness exercise in the control group. the experimental and control groups will be required to practice a total of 50 minutes of qigong and fitness training 3 times per week and for 16 weeks respectively. the main outcome measure is balance capacity with mini-bestest. the secondary outcomes are fall efficacy, number of falls, postural stability and control, depression, physical functions and quality of life. assessments will be done at baseline, 8 weeks and 16 weeks follow-ups by blinded assessors. data analysis: the results will be analyzed using two-way repeated measures analysis of variance with statistical package for social science version 21.0. alpha will be set at 0.05.

Eligibility criteria:
inclusion criteria: * diagnosis of stroke and 3 months after the onset * first episode of stroke or recurrent of stroke * able to stand for more than 15 minutes * able to take anterioposterior and lateral step without assistance or aid * medically stable * sufficient cognition to follow commands abbreviated mental test (amt) score ≥7 exclusion criteria: * vital signs unstable * history or evidence of other neurological deficits other than stroke such as multiple sclerosis * severe primary diseases of the cardiovascular system, liver, kidney or hematopoietic system * experience in qigong practice

Keywords: stroke qigong randomized controlled trial body-mind exercise balance quality of life wellbeing
diet and physical activity interactions in obesity

Conditions: Obesity

Summary: the projects funded by this grant, primarily focus on environmental factors that promote weight-gain in the general human population, and how to modify these factors, to prevent further weight-gain in the future. in the coming years, the researchers at the university of colorado-hsc hope to gain an understanding as to how small changes in diet and physical activity can be achieved and sustained to prevent weight-gain.


Eligibility criteria:
* bmi: 21-26 * \< 5lb. weight change in 6 mo. * usual fat intake 25-35% * regularly eats 3 meals/day * no chronic health problems known to affect appetite * either active or inactive (specific criteria do exist) * no smoking * women must be on bcps * no evidence of depression, eating disorder, or restrained eater (determined from validated questionnaires).
eltrombopag treatment in patients with prolonged bm toxicity after cart

Conditions: CART Treatment; B Cell Lymphoma

Summary: treatment with chimeric antigen receptor-t cell (car-t) is successful in patients who have not responded to chemotherapy or bone marrow transplantation but it may provoke side effects and long-term complications. early and specific side effects include cytokine release syndrome and neurological toxicity. in addition, there are also late side effects. the most prominent of which is bone marrow damage and lack of recovery of blood counts after treatment. in this study, patients with prolong aplasia after car-t will recieve eltrombopag to enahnce bone marrow recovery.

car-t therapy is the standrad of care in patients with relapse/refractory b cell agressive lymphoproliferative diseases. prolonged cytopenia is a not uncommon side effect and is associated with susbstantial morbidity and in severe cases also with mortality. the pathobiologic process that causes bone marrow injury is not known and in order to find appropriate treatment it is important to expand the knowledge regarding this toxicity. current treatment options for bone marrow suppression includes growth factor therapy (gcsf), steroids and immunoglobulins. . the investigators hypothesize that cart cells directly suppress or create inflammatory process in bone marrow. this process may resemble aplastic anemia, a marrow aplasia that occurs secondary to inflammatory process. treatment of aplastic anemia is based on the administration of eltrombopag, that causes a thrombopoietin-mimetic blood cells to develop and multiply. this treatment demonstrated an increase in the amount of platelets and neutrophils in patients with aplastic anemia and is approved by the health authorities around the world and in israel as a standard treatment for this disease. there are several reports of successful use of altrombopag in patients after cart who have developed marrow toxicity and in patients after bone marrow transplantation whose blood counts are low. in this study, patients with prologed aplasia after cart cells therapy, will be given eltrombopag in a purpose to incrase bone marrow function. in addition, the investigators will perform several assays to shed more light on the basic pathologic process that causes the bone marrow aplasia.

Eligibility criteria:
inclusion criteria: 1. willing to participate in the study and able to sign an informed consent form. 2. patients with b cell lymphoma or multiple myeloma who were treated with cart and demonstrated cytopenia on day 14 after cart administration. cytopenia definition: absolute neutrophil count \<500 neutrophils/ul and/or platelets \<50,000 mm3 3. bone marrow demonstrates hypoplasia (cellularity less than 30%) 14 days after cart administration. - exclusion criteria: 1. creatine \> 2.5 mg / dl 2. disorder in liver enzymes: bilirubin above 2 mg/dl , ast or alt 5 times the normal. 3. active infection 4. active hemophagocytic syndrome 5. evidence of a viral or pharmacological disease that causes bone marrow injury 6. susceptibility to eltrombopag 7. evidence of disease in the bone marrow -
tablet-based cognitive training

Conditions: Alzheimer Disease; Dementia; Mild Cognitive Impairment

Summary: today the therapy options for dementia due to alzheimer's disease (ad) are limited. one recommended intervention is cognitive stimulation. we try to develop serious games as a further treatment option, also usable in pre-dementia as well as early stages of dementia and for a long period of time. the main objective of this study is to test, if the computerized-cognitive training (cct) is able to improve the performance in a score quantifying an "ad-specific" component score. additionally, the neurobiological effects of the training are investigated.

the study intervention consists of a computer-based cognitive training, targeting the cognitive domains mostly affected by ad. this training will be performed for three months (each day for 20 minutes). after three months the intervention group will continue the training at home for six months and meet monthly for group sessions (i.e. booster sessions) on site. primary endpoint will be the change in an "ad-specific" component score, quantified by episodic memory, semantic memory and visuospatial abilities. secondary endpoints are changes in task related brain networks and changes in resting state networks.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of alzheimer's disease * patients with increased risk for developing dementia * must be able to give their consent exclusion criteria: * contra-indications for mri scanning * substance abuse * severe medical conditions

Keywords: alzheimer disease dementia mild cognitive impairment cognitive training serious games
evaluation of the efficacy of chinese herbal medicine in patients with obesity

Conditions: Obesity

Summary: obesity is defined as abnormal or excessive fat accumulation. it is a complex disease with multifactorial etiology. although the prevalence of obesity is generally greater in elders and women, obesity rates have increased in all ages and both sexes in recent years. obesity or overweight also has a higher risk of diabetes, metabolic syndrome, dyslipidemia, hypertension, hyperuricemia, gout, osteoarthritis, cardiovascular disease, coronary artery disease, breast cancer, endometrial cancer and colorectal cancer. the body mass index (bmi), calculated as weight in kilograms divided by the square of height in meters, is widely used to define overweight and obesity in clinical studies. in taiwan, subjects with bmi between 24 and 27 were diagnosed of overweight, and those with bmi over 27 were diagnosed of obesity. chinese herbal medicine (chm) was widely used in the treatment of obesity. the main purpose of chm treatment is to promote metabolism, suppress appetite and block intestinal digestion and absorption of fat. since there are various adverse effects of anti-obesity medicines, and there are surgical complications including infection and anastomotic stenosis, patients may seek chm for losing weight. many studies have indicated the efficacy of single herb in the treatment of obesity. currently, the amount of computerized clinical data is increasing rapidly with the adoption of electronic medical records. the study is expected to collect the medical records, including the data of body weight, related side effects and biochemical data of each individual. by comparing the change of related data before and after chm treatment, we could evaluate the efficacy of chm in patients with obesity.


Eligibility criteria:
inclusion criteria: * patients with the diagnosis of obesity (icd-9: 278.00) and received chinese herbal treatment for obesity in outpatient clinic during january 1, 2007 and december 31, 2019. exclusion criteria: * patients who were pregnant or breast feeding during treatment period. * patients who were diagnosed of hopothyroidism or cushing's disease.

Keywords: obesity chinese herbal medicine efficacy side effect
water immersion in right-sided heart failure: a pilot study

Conditions: Right Sided Cardiac Failure

Summary: this is an unblinded pilot study comparing (against a randomized control day without water immersion) the diuretic and natriuretic effects of water immersion in patients with right heart failure.

patients will be immersed in a tub for 3 hours (on one day) and neurohormones will be obtained before and after immersion. urine will be collected for quantification and evaluation of sodium concentration.

Eligibility criteria:
inclusion criteria: * patients must have right sided failure secondary to right ventricular dysfunction, pulmonary hypertension, or tricuspid regurgitation * age greater than 18 years of age * right heart catheterization within the last year to rule out left-sided failure. * evidence of fluid overload as indicated by 2 or more of the following: 1.) 2+ or more pitting edema of the lower extremities, 2.) scrotal or penile edema, 3.) jvp greater than or equal to 10 cm, 4.) abdominal ascites exclusion criteria: * pulmonary capillary wedge pressure above 16 mmhg or history of elevated left ventricular filling pressures. * serum creatinine \> 2.0 * current use of an angiotensin i converting enzyme inhibitor or angiotensin receptor blocker will preclude participation in the ras neurohormone portion of the study.
prospective observational study of pain evolution in patients with primary knee osteoarthritis treated with pronolis® hd

Conditions: Osteo Arthritis Knee

Summary: prospective observational study of 6 months of follow-up, of national and multicenter scope with medical device with ce marking and according to the usual clinical practice. in addition, due to the observational design of the clinical investigation, no assignment of the patients will be made to any specific study group, but will be carried out in accordance with the usual clinical practice, not applying any intervention other than the usual one in this type of care practice and always in accordance with current clinical guidelines and recommendations and with the indications authorized in spain. patients will be recruited by specialists and will be followed for 6 months under the conditions of usual clinical practice.


Eligibility criteria:
inclusion criteria: 1. patients of both sexes and over 18 years. 2. patients with a previous diagnosis of primary knee osteoarthritis according to acr criteria and who have a knee x-ray performed during the previous 18 months. 3. patients who attend a control clinic for primary osteoarthritis of symptomatic knee. 4. patients with pain equal to or greater than 4 on the vas scale. 5. patients who have been prescribed an injection of pronolis® hd as part of the usual clinical practice. 6. patients who have given their written informed consent to participate in the clinical investigation. 7. patients for whom there is a reasonable expectation of follow-up during the development of clinical research. 8. patients who understand and can complete the questionnaires and do not have cognitive impairment that prevents it. exclusion criteria: 1. patients with known intolerance to hyaluronic acid. 2. patients with hypersensitivity to intraarticular injections. 3. patients who present with infection in the knee joint. 4. patients presenting with a skin disorder or infection in the area of injection or systemic. 5. coagulation disorders that contraindicate puncture. 6. patients who have been prescribed intra-articular injection in both knees. 7. patients diagnosed with autoimmune rheumatologic diseases or connective diseases. 8. patients diagnosed with microcrystalline diseases. 9. patients with traumatic history in the study joint. 10. patients with a surgical history in the study joint. 11. pregnant or breastfeeding women.
china takayasu arteritis registry (cta registry)

Conditions: TAKAYASU ARTERITIS

Summary: takayasu arteritis (ta) is a chronic large-vessel vasculitis that mainly affects the aorta and its major branches. the epidemiology and pathophysiology of ta is still unclear in china, although many studies have been done. our previous study supporting by national natural science foundation of china indicated the cytokines such as hs-crp, nt-probnp and tumor necrosis factor-alpha (tnf-α) can be used to monitor ta activity, and hla gene alleles were associated with ta in chinese han population. further investigations with larger samples are needed to fully understand the a pathophysiology of ta. the purpose of this study is to build a chinese national registry system for ta to obtain real-world information, such as current status of characteristics, diagnosis, disease activity, the severity of disease, treatment and outcomes of chinese ta patients. to analysis and development of effective disease monitoring and treatment strategies.

takayasu arteritis (ta) is a chronic vasculitis that causes inflammation of the aorta and its main branches and is characterized by adventitial thickening and cellular infiltration of the tunica media, with local destruction of vascular smooth muscle cells and elastin. the disease is very rare but most commonly occurs in china. in the last decade, the results of our study indicated that hla-dpb1, hla-dqa1, hla-dqb1 and hla-drb1 gene alleles were associated with ta in chinese han population. and the clinical features of patients with ta were analyzed. the cytokines such as hs-crp, nt-probnp and tumor necrosis factor-alpha (tnf-α) can be used to monitor ta activity. but there are still many unknown fields in ta, such as the epidemiology and pathophysiology. this study is to build a chinese national registry system for ta to obtain real-world information, such as current status of characteristics, diagnosis, disease activity, the severity of disease, treatment and outcomes of chinese ta patients. to analysis and development of effective treatment strategies.

Eligibility criteria:
inclusion criteria: * age at disease onset \< 40 years. (development of symptoms or findings related to takayasu arteritis at age \<40 years) * claudication of extremities. (development and worsening of fatigue and discomfort in muscles of 1 or more extremity while in use, especially the upper extremities) * decreased brachial artery pulse. (decreased pulsation of 1 or both brachial arteries) * bp difference \>10 mm hg. (difference of \>10 mm hg in systolic blood pressure between arms) * bruit audible on auscultation over 1 or both subclavian arteries or abdominal aorta. * arteriogram abnormality. (arteriographic narrowing or occlusion of the entire aorta, its primary branches, or large arteries in the proximal upper or lower extremities, not due to arteriosclerosis, fibromuscular dysplasia, or similar causes; changes usually focal or segmental) exclusion criteria: * vessel lesions that could be entirely due to atherosclerosis. * giant cell arteritis or other infectious forms of large vessel vasculitis.

Keywords: takayasu arteritis
study of bioactive glass-ceramic intervertebral spacer (bonglass-ss) in posterior lumbar interbody fusion

Conditions: Degenerative Disk Disease

Summary: the goal of this study is to compare bonglass-ss with titanum cage.


Eligibility criteria:
inclusion criteria: * 30\~80 aged patients needed single-level posterior interbody fusion at l1\~s1 * a subject who provided written informed consent to participate in this study exclusion criteria: * patitents with bmd t-score \< -3.0 * women who are pregnant or plan to be pregnant within 3 years * patient with malignant tumor