sub regional micronutrient survey in ethiopia

Conditions: Iron-deficiency; Vitamin A Deficiency; Zinc Deficiency

Summary: to conduct a sub-regional micronutrient survey (srmns) assessing the prevalence of vitamin a, zn, and fe status in the country

background: in ethiopia, biofortified staple crops, such as high vitamin a maize, high zinc (zn) maize, high zn wheat and high iron (fe) common bean could have a beneficial impact on micronutrient status, as the regular varieties of these crops are eaten in significant amounts in some of the administrative regions. it is however, unknown in which region people would most benefit as data on vitamin a, zn and fe status in the different regions is too limited to efficiently target specific biofortification approaches. objective: the overall objective of the project is to generate data to target and tailor bio fortification approaches in ethiopia. therefore, it is planned to conduct a sub-regional micronutrient surveys (srmns) assessing the prevalence of vitamin a, zn, and fe status in the country. study design: the sub regional micronutrient survey (srmns) will have a cross-sectional design with one measuring point. study population: the srmns will be conducted in 600 children \< 5 years of age and 600 women of reproductive age (18-45 years) living in the regions of kamashi in benishangul gumuz, west gojjam in amhara, and goma gofa in southern nations, nationalities and people's regions (snnp). main study parameters/endpoints: the prevalence of fe, zn and vitamin a deficiency will be assessed by measuring hemoglobin (hb), plasma ferritin (pf), soluble transferrin receptor (stfr), c-reactive protocol (crp), alpha-1-acid glycoprotein (agp), plasma zn (pzn), plasma retinol and retinol binding protein (rbp), respectively. significance: the study will generate important data on the vitamin a, zn and fe status of children and women for sub-regions in ethiopia. such sub-regional data will be more specific than common survey data and therefore be helpful to target bio fortification and identify the populations in ethiopia who will benefit most from high nutrient crops.

Eligibility criteria:
inclusion criteria: * 5-59 months of age for children * 15-49 years for women of reproductive age. * the informed consent form has been read and signed by the caregiver (or has been read out to the caregiver in case of illiteracy) exclusion criteria: * severely wasted and underweight children (weight for height and weight for age z score \< -3, respectively) * chronic or acute illness or other conditions that in the opinion of the principle investigator (pi) or co-researchers would jeopardize the safety or rights of a participant in the trial or would render the participant unable to comply with the protocol * participants taking part in other studies requiring the drawing of blood * long-term medication (except contraceptives for women of reproductive age) * any severe metabolic, gastrointestinal kidney or chronic disease such as diabetes, hepatitis, hypertension, cancer or cardiovascular diseases (according to the participants own statement or examination of study doctor). health records to be checked for the same. * blood losses (surgery, accident), donations or transfusions during the past 4 months before study start.

Keywords: bio fortification