Kornimate/medical-research-clean huggingface dataset:
handled echocardiography and chronic heart failure

Conditions: Chronic Heart Failure

Summary: the aim of the study is to compare two different home monitoring care programs in patients with chronic heart failure in functional class nyha iii, one of them based on clinical and electrocardiographic evaluations, the other one using also periodical handled echocardiographic examinations.

randomized, blinded, controlled, monocentric study comparing two different home monitoring care programs in patients with chronic heart failure in functional class nyha iii, one of them based on clinical and electrocardiographic evaluations every three months, the other one using also periodical handheld echocardiographic examinations at the 6th, 12th and 18th month. the events occurring during the 18 month follow up and the results of the final echocardiography performed in all the patients will be transmitted to and evaluated by an independent observer, unaware of the features of the follow up. at the end of the trial, the randomization code will be opened and the events will be ascribed to the two groups. the primary end point is rehospitalization for worsening of heart failure symptoms and/or for the appearance of major vascular events during the 18 months follow up. secondary end points include home treated vascular events, cardiovascular death and the composite end point death + rehospitalization.

Eligibility criteria:
inclusion criteria: * chronic heart failure in functional class nyha iii * at least once hospitalization during the last year for worsening of clinical symptoms or for the appearance of acute cardiovascular events * patients who cannot easily reach the pertaining sanitary district for different reasons (i.e. the presence of architectural barriers, the absence of a lift, a too great distance between home and sanitary district without someone helping) * age ≥ 70 years * written informed consent exclusion criteria: * patients who were waiting for cardiac surgery or patients who had undergone a cardiac operation within three months
radiotherapy combined with immunotherapy for brain metastases of non-small cell lung cancer

Conditions: Non Small Cell Lung Cancer

Summary: this is a retrospective, multicenter, controlled study to evaluate immunotherapy and radiotherpay for brain lesions as a potential treatment for patients with brain metastasis in non-small cell lung cancer


Eligibility criteria:
inclusion criteria: experimental group: 1. 18 years old ≤ age ≤ 75 years old, no gender limitation; 2. nsclc who have received radiotherapy for brain lesions + pd-1/pd-l1 immunotherapy; 3. histologically confirmed as nsclc; 4. imaging confirmed brain metastasis (ct or mri); 5. the presence of imaging-evaluable lesions can be evaluated in accordance with recist 1.1 control group: 1 18 years old ≤ age ≤ 75 years old, no gender limitation; 2 nsclc who has received radiotherapy for brain lesions; 3 histologically confirmed as non-small cell lung cancer; 4 imaging confirmed brain metastasis (ct or mri); 5 the presence of imaging-evaluable lesions can be evaluated in accordance with recist 1.1 - exclusion criteria: 1 the age is less than 18 years old, regardless of gender; 2 histologically confirmed as nsclc 3 imaging confirmed the absence of brain metastases 4 nsclc with brain metastasis only received chemotherapy or targeted therapy, and did not receive radiotherapy or immunotherapy -
early incentive and mobilization during copd exacerbation

Conditions: Chronic Obstructive Pulmonary Disease

Summary: to study the effects of early exercise training in hospitalized patients for chronic obstructive pulmonary disease exacerbation (copd). interventions are randomized. in one group, early exercise training (aerobic and strength) during hospitalization for copd exacerbation followed by exercise training at home until 30 days to discharge and in the other the intervention is usual care. in both groups, usual respiratory physiotherapy techniques during hospitalization and adequate physical activity recommendations have been included. the main variable is the increase in moderate or vigorous daily physical activities at 30 days after discharge.

prospective randomized study in hospitalized patients for chronic obstructive pulmonary disease exacerbation (copd). in one group, early exercise training (aerobic and strength) during hospitalization for copd exacerbation followed by exercise training at home until 30 days to discharge and in the other the intervention is usual care. in both group, usual respiratory physiotherapy techniques during hospitalization and adequate physical activity recommendations have been included. the main variable is the increase in moderate or vigorous daily physical activities at 30 days after discharge.

Eligibility criteria:
inclusion criteria: * hospitalized patients for copd exacerbation exclusion criteria: * hospitalization within the previous 14 days, * current participation in rehabilitation program, * locomotor or neurological condition or disability limiting the ability to perform exercise, * lung transplantation or lung volume reduction surgery foreseen within 1 month after discharge.

Keywords: chronic obstructive pulmonary disease
dose escalation study of nintedanib (bibf 1120) in japanese patients with hepatocellular carcinoma

Conditions: Carcinoma, Hepatocellular

Summary: the aim of the study is to investigate the safety, tolerability, efficacy and pharmacokinetics (pk) for japanese hepatocellular carcinoma which are not amenable to curative surgery or loco regional therapy


Eligibility criteria:
inclusion criteria: 1. histologically/cytologically confirmed hepatocellular carcinoma not amenable to curative surgery or loco-regional therapy 2. age 20 years or older 3. eastern cooperative oncology group (ecog) performance status (ps) score of 0 or 1 4. child-pugh score of 7 or less 5. life expectancy more than 3 months 6. time interval from last loco-regional therapy more than 4 weeks 7. written informed consent in accordance with good clinical practice (gcp) exclusion criteria: 1. more than one line of prior systemic therapy for metastatic/unresectable hepatocellular carcinoma (hcc) 2. fibrolamellar hcc 3. uncontrolled or refractory ascites 4. inadequate organ function 5. variceal bleeding within 6 months or the presence of inappropriate varices 6. history of major thrombotic (except portal vein thrombosis) or clinically relevant major bleeding event in the past 6 months 7. major surgery within 4 weeks 8. known inherited predisposition to bleeding or thrombosis 9. significant cardiovascular diseases
a study to evaluate the efficacy and safety of celecoxib suspension compared to naproxen suspension in patients with jra

Conditions: Arthritis, Juvenile Rheumatoid

Summary: to study celebrex versus naproxen to see if it decreases symptoms of juvenile arthritis such as pain and swelling.


Eligibility criteria:
inclusion criteria: 2-18 years old with active jra exclusion criteria: other experimental meds, recent changes in arthritis meds

Keywords: arthritis juvenile
a study of the quality of life and treatment response to once weekly epoetin beta (recormon) treatment in anemic participants with solid and lymphoid malignancies

Conditions: Anemia

Summary: this 2 arm study will investigate quality of life response in anemic participants with solid and lymphoid malignancies, who are receiving concomitant chemotherapy. participants with solid and lymphoid malignancies will receive epoetin beta at a dose of 150 international units per kilogram (iu/kg) three times weekly. participants with lymphoid malignancies will receive epoetin beta 30000 iu once weekly.


Eligibility criteria:
inclusion criteria: * anemia and prescribed treatment with epoetin beta * confirmed diagnosis of a solid or lymphoid hematologic malignancy * receiving or scheduled to receive chemotherapy * life expectancy of greater than or equal to (\>=6) months exclusion criteria: * anemia after bleeding, hemolytic anemia, megaloblastic anemia, anemia in chronic kidney failure, lever and endocrinology diseases * contraindications to epoetin beta * administration of epoetin beta during chemotherapy (e.g., on the third day after chemotherapy cycle start) * bleeding within one month before and/or during study * severe infection within one month before and/or during study * inability of participant to fill the questionnaires
quality of life in prostate cancer patients

Conditions: Prostate Cancer

Summary: recording cancer data in cancer registries is essential for producing reliable population-based data for service planning, monitoring and evaluation. prostate cancer (pca) remains the most frequent type of cancer in terms of incidence and mortality in men in the caribbean. the quality of life pca cohort will assess quality of life and patient outcomes in martinique using a digital platform for patient-reported outcome measures.

the martinique cancer registry database is the largest clinical database among the french population-based cancer registries in the caribbean, including more than 38 000 cancer cases, with 1650 new cancer cases per year, including 550 new pca cases per year (2010-2014 latest period). in 2020, follow-up will include vital status, assessment of quality of life with the european organisation for research and treatment of cancer quality of life questionnaire (qlq) core 30 and the prostate cancer module qlq-pr25. urinary incontinence and erectile dysfunction recorded prior to treatment will be analysed 1, 3 and 5 years after treatment.

Eligibility criteria:
inclusion criteria: * age\>18 years and residing in martinique, with prostate cancer diagnosed from 2020 * the patient has provided informed consent * patient with social security coverage exclusion criteria: * refusal to participate * patient with a second cancer, five years after diagnosis * patient who could not answer the quality of life questionnaires * patient not fluent in french * person under legal protection

Keywords: prostate public health quality of life
comparation of endoscopic biopsy and postoperative specimen for the molecular diagnosis of gastric cancer

Conditions: Stomach Neoplasms; Endoscopy; Biopsy; Pathology

Summary: this study aims to test the hypothesis that the diagnosis for histological type, histological grade, lauren type, her-2 expression, msi/dmmr status, and ebv status in gastric cancer is at least as reliable when performed on endoscopic biopsy specimens as on surgical resection specimens.

most institutions currently diagnose gastric cancer on endoscopic biopsy specimens but use surgical resection specimens for histological type, histological grade, lauren type, her-2 expression, msi/dmmr status and ebv status testing. however, gastric cancers treated with neoadjuvant chemoradiotherapy/chemotherapy may undergo a complete pathological response (pcr), with no residual tumors available for testing, and neoadjuvant chemoradiotherapy/chemotherapy may alter the her-2 expression, msi/dmmr status and ebv status of the gastric cancer in some instances. importantly, testing histological type, histological grade, lauren type, her-2 expression, msi/dmmr status and ebv status of gastric cancer on endoscopic biopsy material could be initiated preoperatively, allowing resultant genetic information to be used in consultation with the patient to inform treatment decisions. therefore, the preoperative endoscopic biopsy may be a source of suitable and reliable testing material. this study aims to investigate the correlation between histological type, histological grade, lauren type, her-2 expression, msi/dmmr status, and ebv status in preoperative endoscopic biopsy specimens and their corresponding surgical resection specimens and ascertain whether endoscopic biopsy specimen is a valid and reliable testing material for determining the histological type, histological grade, lauren type, her-2 expression, msi/dmmr status and ebv status of gastric cancer.

Eligibility criteria:
inclusion criteria: 1. lower age limit of research subjects 18 years old and upper age limit of 75 years old. 2. histologically proven primary gastric adenocarcinoma (diagnostic biopsies must be collected within 12 months prior to enrollment). 3. written informed consent from the patient. 4. patients planned for radical r0 gastrectomy. exclusion criteria: 1. female in pregnancy or lactation. 2. patients with gastric cancer who can not undergo tumor resection 3. suffering from other serious diseases, including cardiovascular, respiratory, kidney, or liver disease, complicated by poorly controlled hypertension, diabetes, mental disorders or diseases. 4. patients with poor compliance or considered to be poor compliance. 5. patients received any anticancer drugs, biotherapy, radiotherapy or immunotherapy within 4 weeks before or after enrollment. 6. patients after organ transplantation, long-term need to take immunosuppressants, autoimmune diseases.

Keywords: stomach neoplasms endoscopy biopsy pathology
avoiding neuromuscular blockers to reduce complications

Conditions: Respiratory Failure; Respiratory Infection; Aspiration Pneumonia; Pneumonitis; Atelectasis; Bronchospasm

Summary: the goal of this study to evaluate whether eliminating the use of non-depolarizing neuromuscular blocking agents (nmba) for maintenance of general anesthesia reduces postoperative pulmonary complications in higher risk patients.

pragmatic prospective randomized controlled assessor-blinded effect-size finding trial involving approximately 100 patients total at two academic tertiary care hospitals: beth israel deaconess medical center (bidmc) and massachusetts general hospital (mgh). patients will be randomized into one of two study groups: standard care group which uses rocuronium (nmba) as an adjunct for maintenance of general anesthesia and non-relaxant arm that avoids the use of nmba and instead uses additional inhalational anesthetics, opioids, propofol, dexmedetomidine, or ketamine for maintenance of general anesthesia. assessment of postoperative pulmonary complications and in-hospital mortality would be achieved by close review of the patient's medical records during the hospital stay, for a maximum of 28 days.

Eligibility criteria:
inclusion criteria: * at least 18 years of age * undergoing non-cardiac surgery under general anesthesia with an endotracheal tube * those at higher risk of developing postoperative pulmonary complications (internally validated risk prediction score of \>=20) exclusion criteria: * emergency surgery * ambulatory (outpatient) surgery * scheduled for elective postoperative ventilation * planned return to operating room within 7 days of index procedure * exposure to general anesthesia within 7 days prior to planned procedure * requirement mechanical ventilation at baseline (not including stable use of cpap/bipap) * pregnant patients: as detected by patient self-reporting or diagnosed by preoperative pregnancy testing according to institutional policies at bidmc and mgh * allergy to either non-depolarizing muscle relaxants or sugammadex * clinician refusal * prisoner

Keywords: neuromuscular blocker avoidance post operative pulmonary complications general anesthesia maintenance inhaled anesthetics
phase 1 study of the effect of ketoconazole on the pk of multiple doses of cediranib in patients with solid tumours

Conditions: Advanced Solid Tumors

Summary: phase i, open study to assess the effect of ketoconazole, a marketed drug, on the way the body handles the experimental drug cediranib, in patients with advanced cancer.


Eligibility criteria:
inclusion criteria: * written informed consent * histological or cytological confirmation of advanced solid tumour (with the exception of prostate cancer), which is refractory to standard therapies or for which no standard therapy exists. * estimated life expectancy of at least 8 weeks * who performance status (ps) 0-2. exclusion criteria: * unstable brain/meningeal metastases * biochemistry/haematology results outside of required ranges * history of significant gi impairment * inadequate bone marrow reserve

Keywords: advanced cancer, metastatic ketoconazole pharmacokinetics phase i
melatonin study between diminished and normal responder in ivf

Conditions: Infertility, Female

Summary: poor sleep quality may lead to increase in oxidative stress and free radicals which in turn may decrease the reproductive function. many researchers have already proven improvement on reproductive function after antioxidant (melatonin) administration. the investigators wish to study the relationship between unexplained, young poor ovarian responder and oxidative stress.

poor sleep quality may lead to increase in oxidative stress and free radicals which in turn may decrease the reproductive function. many researchers have already proven improvement on reproductive function after antioxidant (melatonin) administration. the investigators wish to study the relationship between unexplained, young poor ovarian responder and oxidative stress. this is an randomized controlled trial to evaluate the effect of melatonin to improve the quality of sleep and reduce the oxidative stress. 100 patients will be randomized in to two groups, the one with melatonin administration for 2 weeks and the other with placebo administration. each group will be composed of 2 sub groups, poor responders and normal responders. then the serum and the follicular fluid will be collected at the time of oocyte retrieval and melatonin concentration oxidative stress marker will be measured.

Eligibility criteria:
inclusion criteria: 1. infertility patients visiting bundang cha hospital between the age of 20 to 40. 2. currently, not being treated for any gynecological or medical diseases. exclusion criteria: 1. current untreated pelvic pathology (moderate-to-severe endometriosis, submucosal uterine fibroids/polyps assessed by the treating specialist to affect fertility, pelvic inflammatory disease,uterine malformations, and hydrosalpinx.) 2. currently enrolled in another interventional clinical trial. 3. concurrent use of other adjuvant therapies (e.g.chinese herbs, acupuncture). 4. autoimmune disorders. 5. undergoing preimplantation genetic diagnosis. 6. concurrent use of any of the following medications (fluvoxamine,cimetidine, quinolones, carbamazepine, rifampicin,zolpidem, zopiclone, and other non-benzodiazepine hypnotic, other cyp1a2 inducers. 7. genetic disorders regarding galactose intolerance, lactase deficiency, glucose-galactose malabsorption 8. inability to comply with trial protocol.

Keywords: oxidative stress antioxidants diminished ovarian reserve
pulmonary rehabilitation in improving lung function in patients with locally advanced non-small cell lung cancer undergoing chemoradiation

Conditions: Cachexia; Fatigue; Pulmonary Complications; Radiation Toxicity; Recurrent Non-small Cell Lung Cancer; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer

Summary: this randomized clinical trial studies pulmonary rehabilitation in improving lung function in patients with locally advanced non-small cell lung cancer undergoing chemoradiation. individualized exercise rehabilitation programs may reduce breathing problems and improve quality of life in patients with non-small cell lung cancer. it is not yet known whether pulmonary rehabilitation is more effective when started during or after cancer treatment.

primary objectives: i. to determine feasibility of pulmonary rehabilitation (pr) in patients with locally advanced unresectable non-small cell lung cancer (nsclc) undergoing definite chemotherapy and radiation therapy. ii. to measure exercise capacity and respiratory symptoms in lung cancer patients receiving chemotherapy and radiation before and after pulmonary rehabilitation. iii. to compare if there are any differences in symptom relief, exercise capacity, and cancer treatment tolerability between performing pulmonary rehabilitation during chemo-radiation versus after completion of lung cancer treatment. outline: patients are randomized to 1 of 2 arms. arm i: beginning within 2 weeks of starting chemoradiation, patients undergo an individualized rehabilitation program comprising aerobic exercise and strength training, including treadmill walking, stationary bicycle, nu-step, upper body resistance training and breathing retraining, 3 times per week for 8 weeks (36 sessions). arm ii: beginning 1 month after completion of chemoradiation, patients undergo an individualized exercise rehabilitation program as in arm i.

Eligibility criteria:
inclusion criteria: * patients who have been diagnosed with locally advanced unresectable nsclc undergoing definite chemo-radiation with curative intent * patients must be able to sign informed consent * patients who qualify for pulmonary rehabilitation as part of the standard of care and are covered by medical insurance * patients must be able to ambulate a minimum of 100 feet prior to enrollment in pulmonary rehab * patients must be willing and able to travel to the pulmonary rehabilitation site at the morehouse medical plaza exclusion criteria: * tumor resection candidates * if survival is deemed less than 6 months for any medical condition * if they have angina or unstable coronary disease * congestive heart failure refractory to medical management * malignancy with bone instability * inmates

Keywords: pulmonary rehabilitation non-small cell lung cancer nsclc
a feasible smart upper limb rehabilitation model for patients with stroke and spinal cord injuries

Conditions: Stroke; Spinal Cord Injuries

Summary: the goal of this clinical trial is to investigate the effectiveness of the developed application and exoskeleton robot devices for home-based training in stroke patients and patients with spinal cord injuries. the application that uses an internet of things (iot) platform to enable remote monitoring of rehabilitation progress by clinical practitioners. simultaneously, it seeks to assist the execution of patient movements through devices. in patients with stroke, half of the participants will be assigned to experimental group, receiving a smart upper limb motor rehabilitation system for home program. the other half will be assigned to control group, receiving a traditional home program. in patients with spinal cord injuries. participants will follow the same allocation method for home-based intervention. researchers will conduct an analysis before and after intervention, examining progress in motor function, activities of daily living, and quality of life.


Eligibility criteria:
inclusion criteria: for patients with stroke * 20-79 years old. * the score of montreal cognitive assessment is more than or equal to 26. * the unilateral hemorrhagic or ischemic participants. * the performance of upper limb movement is affected by damage to brain cells. inclusion criteria: for patients with spinal cord injury * 20-65 years old. * the score of mini-mental status examination is more than or equal to 25. * diagnosed as incomplete spinal cord injury at the c5 or c6 level. exclusion criteria: for patients with stroke * underwent sugery on the shoulder, elbow or wrist. * severe pain in upper limb. * another muscular or neurological diseases that effects motor performance. exclusion criteria: for patients with spinal cord injury * underwent sugery on the shoulder, elbow or wrist. * severe pain in upper limb. * another muscular or neurological diseases that effects motor performance.

Keywords: stroke spinal cord injury robot-assisted therapy tele-rehabilitation
study on therapy of non-invasive prolactinoma

Conditions: Prolactinoma

Summary: the study aim to investigate the endocrine remission rate of non-invasive prolactinoma between transsphenoidal surgery treatment and dopamine agonist treatment.

non-invasive prolactinomas were treated by transsphenoidal surgery or dopamine agonist until now. however，this two type therapies were controversial. the study aim to investigate the endocrine remission rate of non-invasive prolactinoma between transsphenoidal surgery treatment and dopamine agonist treatment.

Eligibility criteria:
inclusion criteria: non-invasive prolactionma exclusion criteria: invasive prolactioma

Keywords: non-invasive prolactinoma