Kornimate/medical-research-clean huggingface dataset:
a study to evaluate the efficacy and safety of zingo in chinese children

Conditions: Catheter Site Pain; Pain, Acute; Anesthesia, Local

Summary: the purpose of the study is to evaluate the efficacy and safety of zingo in treating pain associated with venipunture and peripheral venous cannulation.


Eligibility criteria:
inclusion criteria: * male or female aged 3-12 * about to undergo venipuncture or peripheral venous cannulation at the back of the hand or antecubital fossa * have sufficient cognitive skills to identify faces depicting extremes of pain on the wong-baker faces scale (age 3-12) and the extremes of pain on a 100 mm visual analog scale (vas) (ages 8-12) * signed informed consent, cooperative and agree to attend follow-up visits exclusion criteria: * any medical condition, non-compliance or instability (including but not limited to exceptionally upset, crying, anxiety) that in the judgement of the investigator might adversely affect the conduct of the study * used any (including external or inhaled) sedatives, analgesics, anaesthetics or other agents/device that may affect the efficacy assessment * subjects with tattoos, surgical scars, ports, implantable devices or a skin condition (e.g. excessive body hair) that may have interfered with the placement of zingo or skin site assessments * active local infection or other skin pathology at the site of venipuncture or peripheral venous cannulation. * venipuncture of peripheral venous cannulation at the proposed site within the prior two weeks (longer if the wound is apparent) * previous history of allergic reactions to any local anaesthetic or tape/adhesive dressing. * participated in a clinical trial within three months prior to administration of study drug, or have already enrolled in a zingo clinical trial before * at the discretion of the investigator, any subjects that may have to be withdrawn from the study
preimplantation genetic testing for aneuploidy of polar bodies

Conditions: Subfertility

Summary: this study intends to randomly group the patients with advanced maternal age and poor ovarian response, and the study group will undergo polar body biopsy, and the next-generation sequencing(ngs) technology will be used to evaluate the polar body euploidy and then predict the euploidy of the oocyte. embryo transfer priority according to the ngs test results and morphological scores. in the control group undergo routine culture and the transfer priority is determined according to the morphological score only. the transfer of frozen embryos at the cleavage or blastocyst stage was permitted. cumulative live birth rate, miscarriage rate and time required to obtain a live birth up to two ovulatory cycles in a year.


Eligibility criteria:
inclusion criteria: * patients between their 36th and 42st birthdays; * absence of any type of genetic abnormality in the patient's personal and family history; * mⅱ oocytes: 2-9 . exclusion criteria: * treatment involving donor oocytes; * any type of genetic abnormality or family history of genetic abnormality in subject or partner; * with assisted reproductive technology and pregnancy contraindications and with diseases that have a definite effect on pregnancy; * poor embryo quality in previous cycles; * preimplantation genetic testing for aneuploidy(pgt-a) cycles; * mⅱ oocytes ≥10 or ≤ 1; * three or more previous failed ivf or intracytoplasmic sperm injection(icsi) cycles.

Keywords: poor ovarian respond， advanced age preimplantation genetic testing
a trial of vitamin d and health advice for the prevention of upper respiratory tract infections

Conditions: Upper Respiratory Tract Infections; Rhinovirus; Infections

Summary: the specific objectives of this investigation are to assess the effectiveness of daily gargling and vitamin d supplementation as preventative measures against incident upper respiratory tract infection (urti) in students attending mcmaster university. investigators hypothesize that 1. vitamin d3 supplementation will decrease the incidence of symptomatic upper respiratory tract infections in university students 2. gargling will decrease the incidence of symptomatic upper respiratory tract infections in university students.

in the current study, we propose investigating the roles of vitamin d supplementation and of regular gargling to prevent urti/ili. vitamin d may be an important factor in respiratory health. observational studies have associated low serum 25(oh)d levels with more frequent and more severe respiratory infections. however, evidence is lacking that replacement of vitamin d decreases respiratory infections. four interventional studies of vitamin d supplementation have noted a reduction in respiratory infections, with an estimated 5-25% reduction, but results were not statistically significant. in japanese populations, gargling has been found to significantly reduce the incidence of upper respiratory tract infections by approximately 35% (satomura et al., 2005). this intervention has not been studied in different populations but may be a useful personal practice to reduce urti. we propose a 2x2 factorial, randomized, placebo-controlled trial of vitamin d/placebo and gargling/no gargling to study the effects of vitamin d supplementation and gargling on upper respiratory tract infections in mcmaster students. this study will be conducted over two years, during september and october of each study year, to capture the natural peak in rhinovirus activity.

Eligibility criteria:
inclusion criteria: * current or part-time student at mcmaster university * 17 year of age or older * currently living: i. in residence or, ii. off-campus with at least one student housemate * willing and able to sign an informed consent exclusion criteria: * students who do not meet the inclusion criteria * currently living at home with parents * history or diagnosis of hypercalcemia * diagnosis of parathyroid disorder (hyper or hypo) * diagnosis of chronic kidney disease * use of anticonvulsants * malabsorption syndromes * diagnosis of sarcoidosis * currently pregnant or planning a pregnancy * inability to swallow capsules

Keywords: upper respiratory tract infections rhinovirus infections vitamin d
is cryosurgery or curettage more effective at treating seborrheic keratoses?

Conditions: Seborrheic Keratosis

Summary: seborrheic keratoses (sk's) are very common, but harmless skin lesions that commonly appear during adult life. patients with seborrheic keratoses frequently desire treatment due to symptoms of itching and irritation or for cosmetic purposes. seborrheic keratoses can be easily removed and have been treated in a number of different ways. two of the simplest and most successful ways to remove seborrheic keratoses are cryosurgery and curettage. the investigators are conducting this study to see which of these two treatments has the best result. approximately 24-30 people will take part in this research study at the hershey medical center.


Eligibility criteria:
inclusion criteria: * have at least 1 seborrheic keratosis on each side of his/her trunk or proximal extremities. * be able to understand the consent form and evaluation of treatment questionnaire. exclusion criteria: * children \<18 are excluded from this study based on their inability to independently complete the informed consent and research associated questionnaire.

Keywords: seborrheic keratoses cryosurgery curettage
change neo™ ta registry with acurate neo™ aortic bioprosthesis and acurate neo™ ta transapical delivery system

Conditions: Aortic Stenosis

Summary: the purpose of this registry is to collect specific health and patient data to identify more precisely the patient population undergoing ta aortic valve replacement with the acurate neo™ aortic biprosthesis and acurate neo™ ta transapical delivery system. safety and efficacy data will be collected to support the commercial use of the acurate neo™ aortic bioprosthesis and acurate neo™ ta transapical delivery system in a specific ta population. as per ifu, the acurate neo™ and its acurate neo™ ta delivery system are intended for use in minimally invasive, transcatheter aortic valve replacement using transapical access in patients presenting with severe aortic valve stenosis.

the primary objective of this post-market registry is to collect specific health and patient characteristics to understand the indication for ta-tavi and to further evaluate the safety and performance of the acurate neo ™ aortic bioprosthesis and acurate neo™ ta transapical delivery system in a specific ta population, consisting of 200 consented patients.

Eligibility criteria:
inclusion criteria: * symptomatic patients with severe aortic stenosis; * institution heart team determines that aortic valve replacement acurate neotm device using its transapical delivery system is appropriate; exclusion criteria: - patients unable or unwilling to give inform consent;

Keywords: tavi transcatheter aortic valve replacement transcatheter aortic valve transapical access
the impact of oligosaccharides and bifidobacteria on the intestinal microflora of premature infants

Conditions: Fecal Microflora in the Formula Fed Premature Infant

Summary: the purpose of this study is to see whether dietary supplements can change the germs in the intestines of premature infants to be more like those of healthy breast fed term babies.

to determine the optimum dose and optimum dietary supplement to promote a fecal microflora in the formula fed premature infant that is similar to that of the term breast fed infant (a predominance of bifidobacteria). in the initial phase of this trial, 30 premature infants will be randomly assigned to receive increasing doses of one of four dietary supplements: permeate (a pasteurized human milk concentrate containing human milk oligosaccharides processed by prolacta), gos (galacto-oligosaccharides manufactured by friesland foods), bifidobacterium infantis or bifidobacterium animalis. weekly stool specimens will be examined by pcr to determine content of bifidobacteria and total bacteria. this study is limited to formula fed infants in order to avoid the confounding effects of the human milk oligosaccharides in breast milk. an additional 12 human milk fed infants will be enrolled and will have their diet supplemented with prolactplus (a pasteurized human milk concentrate containing humna milk oligosaccharides) or powdered human milk fortifier for comparison

Eligibility criteria:
inclusion criteria: * born in or transferred to ucdmc within the first two weeks of life. birth weight less than 1500 grams. gestational age less than 33 completed weeks. exclusively formula fed. exclusion criteria: * gastrointestinal or cardiac anomalies.

Keywords: probiotic prebiotic oligosaccharides gos galacto oligosaccharides bifidobacterium infantis bifidobacterium animalis
extubation times in postoperative congenital cardiovascular surgeries

Conditions: Congenital Heart Disease

Summary: background: anesthesia management in pediatric cardiac surgeries focuses on reducing morbidity and mortality, early mobilization and discharge, using health resources sparingly and increasing the quality of life of patients. the duration of postoperative mechanical ventilation is one of the most important factors affecting the process after pediatric cardiac surgery. besides the view that postoperative mechanical ventilation is safe, there are opposing views that it causes an increase in complications; it caused disagreements about extubation times. in our study, we aimed to investigate the factors affecting extubation times after pediatric cardiac surgery. methods: 72 asa≥iii pediatric patients undergoing cardiac surgery with cardiopulmonary bypass were included in our study. the patients were divided into 3 groups according to their extubation time. those that were extubated in the operating room (or) or in 6 hours after surgery (immediate extubation or ie), those that were extubated within 6-48 hours of admission to the icu (early extubation or ee) and those that were extubated sometime after 48 hours or not extubated (delayed extubation or de). many variables of preoperative, peroperative and postoperative periods were recorded to see which factors correlated with extubation times.

children with critical congenital heart disease may need surgical or interventional procedures at some point in their lives.in pediatric cardiac anesthesia, it is important to reduce the need for postoperative mechanical ventilation in order to minimize morbidity, provide optimal vital functions, and reduce unnecessary use of health resources. researchers aimed to examine the relationships of perioperative and postoperative hemodynamics, laboratory, oxygenation parameters and demographic data with extubation times in pediatric cardiac surgery cases taken in the hospital.

Eligibility criteria:
inclusion criteria: * elective or emergency patients * aged 0-18 who are scheduled for congenital heart surgery exclusion criteria: -in patients who died during the operation

Keywords: congenital heart disease perioperative management pediatric cardiac surgery extubation
pioneering advances in care and education (pace)

Conditions: Decision Support Systems, Clinical; Prostate Cancer

Summary: this clinical trial evaluates the use of novel decision support educational materials and services using health coaches. the study includes men newly diagnosed with low-risk prostate cancer. a 160 men will be recruited. half of the men will receive a call from a health coach before their initial consultation visit with their urologist to review their treatment concerns and questions. the other half will receive usual care provided by the urologist, such as educational materials and services provided by the urologist.

a critical public health need exists for improved prognostic tools to distinguish aggressive from slow growing prostate cancer at diagnosis, and for better support systems to guide patients in decision-making regarding management options. decision support interventions that are tailored to specific clinical conditions are known to have increased patient self-efficacy, knowledge, question-asking, and satisfaction; and decreased decisional conflict, regret, anxiety, and distress. to reduce the risk of over-treatment, our team has developed individual risk prediction models that we have now integrated into our decision support intervention (dsi). delivering such decision support intervention should increase patient knowledge and question-asking by the patient to their doctor. the decision support intervention can be delivered by telephone and or the internet.

Eligibility criteria:
inclusion criteria: * male \>=18 years of age and newly diagnosed prostate cancer (pca) (within 3-months). * documentation of a low-risk pca diagnosis as evidenced by clinical features of the following criteria: * psa test at diagnosis \<=15 ng/ml * localized pca (ct1/t2,n0,m0) * biopsy gleason grade 2-6 or (or 3+4 and \<=33% cores are positive for adenocarcinoma) \*\*\*a minimum of 10 diagnostic cores taken by a systematic directed approach. sampling may be obtained by target transrectal ultrasound (trus) or mri imaging. * no treatment yet * no previous radiation or simultaneous use of androgen deprivation * prior use of 5-alpha reductase inhibitor is allowed if they have been stopped for 6 or more months and biopsy performed when patient was not taking the drug * english language proficient and ability to provide informed consent * managing urologist considers them a candidate for active surveillance * written informed consent (and assent when applicable) obtained from subject and ability for subject to comply with the requirements of the study, including the ability to read and speak english. exclusion criteria: * participants will be ineligible if they: 1. have pursued any active therapy for prostate cancer will be excluded; 2. are unable to read/speak english; or 3. if their managing urologist does not deem them as a candidate for active surveillance.

Keywords: prostate cancer transformative impact award early stage active surveillance decision aid coaching session personalized university of california, san francisco (ucsf) validation
physiologic interactions between the adrenal- and the parathyroid glands

Conditions: Osteoporosis; Vitamin D Deficiency; Cardiovascular Disease

Summary: to investigate possible physiologic interactions between the adrenal- and the parathyroid glands in patients with secondary hyperparathyroidism.

in primary hyperparathyroidism, chronic-elevated pth levels seem to stimulate the renin-angiotensin-aldosterone system (raas) which may explain the increased risk of cardiovascular disease. in addition to increased pth levels, vitamin d has been shown to inhibit the raas. however, a possible physiologic interaction needs further investigation. the purpose of the study is to investigate changes in the raas in otherwise healthy postmenopausal women with secondary hyperparathyroidism due to vitamin d deficiency when p-pth is normalized. furthermore, we will evaluate whether an angiotensin 2 receptor blocker can lower pth in patients with secondary hyperparathyroidism.

Eligibility criteria:
inclusion criteria: * secondary hyperparathyroidism due to vitamin d deficiency exclusion criteria: * cardiovascular disease * renal failure * liver failure * treatment with antihypertensive medication or diuretics * treatment with lithium, nsaid or glucocorticoids * calcium supplement more than 500 mg per day or vitamin d supplement more than 25 microgram per day * medical treatment for osteoporosis * systolic blood pressure below 120 mmhg * hypercalcaemia (more than 1,33mmol/l) * use of solarium or planned trip to countries, that might increase the endogenous vitamin d synthesis * allergic reaction to acei or arbs.
t-cell mitochondrial respiration response to ketone monoester supplement in healthy volunteers and covid-19

Conditions: COVID-19 Acute Respiratory Distress Syndrome

Summary: t-cell mitochondrial respiration response to ketone monoester (ketoneaid) in healthy volunteers and covid-19


Eligibility criteria:
inclusion criteria: covid-19 with ards and on the ventilator exclusion criteria: * pregnant * \<18 years * steroid use

Keywords: mitochondria ketone monoester seahorse ketoneaid src fccp ecar
postoperative intervention educational program on the quality of life of patients with hip fracture

Conditions: Hip Fractures; Quality of Life

Summary: the objective of this study is to determine the impact of a postoperative educational intervention program on the health-related quality of life (hrqol) of patients with hip fracture using a controlled clinical trial in a randomized, multicenter study. a total of 224 patients will be recruited, 102 patients from trauma units at the two university hospitals of the province of cáceres will receive the educational program, whereas 122 will not. patients will consecutively included in either an intervention or a control group. patients from the intervention group reill eceive an educational program during admission and the postoperative period. patients from the control group will not receive any educational program. these patients will manage according to routine protocols.

this study will be perform by spanish nurses.

Eligibility criteria:
inclusion criteria: * patients over 65 years of age * diagnosis of hip fracture * previous urgent surgical intervention for surgical fixation of the fracture exclusion criteria: * cognitive impairment * terminal situation
perthes disease in norway

Conditions: Legg Calve Perthes Disease

Summary: calvé-legg-perthes disease (clp) is a hip disease in children whose femoral head becomes completely or partially necrotic. the disease is most common in five-six years of age. the femoral head is gradually deformed during the active stages of the disease (5-7 years). by healing, the hip joint shape will vary from an approximately normal joint to pronounced changes, the hip joint will be irregular. such a hip joint is available for osteoarthritis. the purpose of this study is to map the function of the hip, the patient's quality of life and especially the risk factors that affect the outcome of the previous clp. a nationwide prospective study of clp was conducted between 1996 and 2000. all children with newly diagnosed perthes disease (425) were registered. the current study will follow up all these patients with an average follow-up of 20 years. radiological endpoints are evidence of hip osteoarthritis. patient-reported outcomes (proms) should illuminate the function of the hip and quality of life.


Eligibility criteria:
inclusion criteria - subject was diagnosed with perthes disease between 1996 and 2000 in norway exclusion criteria: * death upon follow up * other skeletal dysplasia * patient not able to give consent,

Keywords: hip function quality of life osteoarthritis perthes lcpd
russian registry of acute coronary syndrome treatment and approach in dual antiplatelet therapy

Conditions: Acute Coronary Syndrome

Summary: this nis is a multi-centre, observational, descriptive, cross-sectional study including all consecutive patients with acute coronary syndrome (acs) and a single-arm, prospective, longitudinal cohort study which will include patients hospitalized for acs and who are with ticagrelor on discharge from hospital.


Eligibility criteria:
inclusion criteria: * part a,b: subjects whose data have been entered in the russian acs registry * part a,b: discharged from hospital after mi with st-segment elevation (stemi), mi nst segment elevation (nstemi) or unstable angina. hospitalized during 24 hours of acs symptoms onset * part b: patients on ticagrelor at the time of discharge from hospital exclusion criteria: * the existence of serious / severe concomitant diseases which can in the short term (i.e. within 6 months) limit the duration of life * current participation in a clinical trial with a non-licensed investigational medicinal product

Keywords: acute coronary syndrome russian acs registry ticagrelor
manual therapy to treat acute whiplash injury

Conditions: Whiplash Injuries

Summary: the purpose of this study is to determine the short-term effects of a manual therapy protocol on pain, disability and cervical range of motion in individuals with acute whiplash injury.

design: randomized clinical trial. objectives: to determine the short-term effects of a a manual therapy protocol on pain, disability and cervical range of motion in individuals with acute whiplash injury. methods and measures: sixty patients will be randomly assigned to 1 of 2 groups: the experimental group received a manual therapy protocol and the placebo group received two manual therapy techniques. neck pain, disability and cervical range of motion data will be collected at baseline and 24-hr after the last manual therapy application. mixed-model analyses of variance will be used to examine the effects of the treatment on each outcome variable.

Eligibility criteria:
inclusion criteria: * to met quebec task force classification of wad ii- neck pain symptoms and musculoskeletal signs. * no evidence of conduction loss on clinical neurological examination. exclusion criteria: * concussion during the motor vehicle accident. * loss of consciousness. * head or upper quadrant injury during the accident. * sought treatment prior to their accident for neck pain. * a previous history of whiplash * neck pain * headaches * psychiatric or psychologic condition * neurologic or circulatory disorders

Keywords: cervical spine neck pain manual therapy controlled clinical trial