Kornimate/medical-research-clean huggingface dataset:
respiratory variations for predicting fluid responsiveness

Conditions: Sepsis; Respiratory Physiological Phenomena; Circulatory Failure

Summary: hypovolemia and acute circulatory failure affects more than 60% of patients hospitalized in intensive care or resuscitation. the volume expansion (ve) by fluid replacement therapy is the first treatment improve circulatory function. however, too much ve can be harmful. so, the use of dynamic predictive indicators of fluid responsiveness is recommended in patients with sepsis.in patients with spontaneous ventilation, few studies have evaluated these parameters. in mechanical ventilation, indices based on the respiratory variation of the diameters of vena cava have been studied and validated to predict the response to ve. however there is no similar study in spontaneously breathing patients without ventilatory support. the investigators hypothesize that the respiratory variations in the ivc diameters and femoral artery flow during standardized respiratory cycles are predictive factors of fluid responsiveness in spontaneously breathing patients with sepsis, acute circulatory failure, and regular cardiac rhythm.


Eligibility criteria:
inclusion criteria: * adult patients of the intensive care units of the lille university-hospital and of the valenciennes general hospital. * age greater than or equal to 18. * patient insured * spontaneous breathing without ventilatory support or intubation or tracheotomy. * regular cardiac rhythm * prescription by the physician in charge of the patients of a 500 ml volume expansion in less than 30 minutes. * patients with sepsis with at least one sign of acute circulatory failure: * tachycardia with heart rate\> 100/min * systolic blood pressure \ 40mmhg in previously hypertense patient * oliguria \<0.5ml/kg/hour for at least one hour * skin mottling exclusion criteria: * high-grade aortic insufficiency * transthoracic echogenicity unsuitable for measuring the stroke volume or inferior vena cava diameters * clinical signs of active exhalation * clinical or ultrasonographic evidence of pulmonary edema due to heart failure * pregnancy * abdominal compartment syndrome * irregular cardiac rhythm

Keywords: spontaneous ventilation
phase iiib study of apd421 in combination as ponv prophylaxis

Conditions: PONV

Summary: a comparison of the efficacy of apd421 and placebo when combined with a standard anti-emetic in the prevention of ponv in patients at high risk of post-operative nausea and vomiting (ponv).


Eligibility criteria:
inclusion criteria: * male or female patients ≥ 18 years of age * patients undergoing elective surgery (open or laparoscopic technique) under general anaesthesia, expected to last at least one hour from induction of anaesthesia to wound closure * patients with at least 3 "apfel" risk factors for ponv exclusion criteria: * patients scheduled to undergo transplant surgery * patients scheduled to receive only a local anaesthetic/regional neuraxial (intrathecal or epidural) block * patients who are expected to remain ventilated for a period after surgery * patients who are expected to need a naso- or orogastric tube in situ after surgery is completed
the pharmacokinetics of 2% td1414 cream in adults with secondarily infected traumatic lesions (sitl) or impetigo

Conditions: Secondarily Infected Traumatic Lesions (SITL); Impetigo

Summary: a national, prospective single arm phase ii study investigating the pharmacokinetics and safety of the 2% td1414 cream when applied 3 times daily for 7 days to adult patients with impetigo or secondarily infected traumatic lesions (sitl). a total of 20 patients will be enrolled.


Eligibility criteria:
inclusion criteria: * ability and willingness to comply with all the study requirements/procedures * age ≥ 18 and ≤65 years * primary bullous/non-bullous impetigo or sitl * patients suffering from primary bullous/non-bullous impetigo must have: * not more than 10 discrete lesions, and * a total lesional area ≥ 1 cm2 and ≤ 100 cm2, and * any surrounding erythema must not extend beyond 2 cm from the edge of the lesion, and * total sirs score equal to or ≥ 8 * patients suffering from sitl must have: * a total infected area of the traumatic lesion ≥ 1 cm2 and ≤ 100 cm2, and * any surrounding erythema must not extend beyond 2 cm from the edge of the lesion, and * total sirs score ≥ 8, and * sitl not caused by burns or animal/human bite * amenable for treatment with topical antibiotic alone * body mass index ≥18 and ≤ 35 kg/m2. exclusion criteria: * immunosuppressed state or other serious systemic disease * signs and/or symptoms of systemic infection, such as malaise and fever or local adenopathy and fever * unwillingness to abstain from use of any other topical products including emollients on the lesional area during the study * systemic treatment with antibacterials or immunosuppressive agents (e.g. corticosteroids) within 2 days before day 1 (inhaled/intranasal steroids may be used) * topical treatment with antibacterials, immunosuppressive agents (e.g. corticosteroids) or antiseptics (e.g. alcohol, chlorhexidine, hydrogen peroxide, iodine) on the lesional area within 2 days before day 1 * indication for surgical or systemic treatment of the sitl/impetigo * known or suspected hypersensitivity to any of the components of the study medication * participation in any other interventional clinical trial or use of an investigational drug within 30 days or 5 half-lives (whichever is longer) prior to day 1 * previously enrolled in this study * a blood alcohol content ≥ 0.08% as determined by a breathalyzer test * known or suspected history of alcohol abuse/alcoholism or drug abuse * known or suspected impairment of liver function * heart rhythm disturbances or clinically significant quantitative or qualitative abnormality in the pretreatment ecg * blood donation in excess of 500ml within 56 days before day 1 or donation during the study or within 3 days of leaving the study.
a retrospective analysis of failures of oral implants

Conditions: Dental Implant Failure; Periodontal Bone Loss

Summary: the purpose of this retrospective study is to investigate and identify factors associated with the failure of dental implants within the population rehabilitated with dental implants at the folktandvården specialistklinik in malmö (spårvägsgatan 12, 214 27, malmö).

this is a retrospective study that involves collecting information about the past and comparing that with contemporary information collected from the same cases. the patients' dental records' archive and the digital dental records of the folktandvården specialistklinik in malmö will be scrutinized. the patients will be retraced in the swedish personal data system and will be invited for a recall visit with a clinical and radiographic examination. the patients will then be informed of the design of the study through the reading of the form for patient information and the informed consent in swedish and verbally. in case the patient is not willing to pay a recall visit, only the data of the patient's records will be used, under the patients' approval. the data from the patients' records will be directly inserted to a computer file of the statistical software statistical package for the social sciences (spss inc., chicago, usa). the additional follow-up information from the patients' recall visit will be collected in specific forms and then inserted to the previously mentioned computer file. all dental implants inserted will be included in the study. data will be categorized as surgical, implant-specific, patient-related, anatomic, loading conditions, prosthetic, and trans- and postoperative complications. periapical radiographies of the patients' digital record will be neatly filed in a computer file. periapical radiographies that could possibly exist in celluloid film will be digitalized. from each patient, additional radiographs will be selected from the patient's record, based on availability in several time intervals. at the recall consultation, new periapical radiographies will be taken. the reference point will be established at the implants-abutment junction, and the marginal bone level measurement will be performed by using the image j software.

Eligibility criteria:
inclusion criteria: * all treated patients with dental implants placed and restored at the avdelning för oral protetik at the folktandvården specialistklinik in malmö with an available dental record; * patients having read, understood, and signed the form for patient information and the informed consent. exclusion criteria: * patients not willing to give their permission to scrutinize their records; * lack of enough data in the patients' dental records.

Keywords: dental implants periodontal bone loss
multi-channel automated diet and physical activity intervention for pre-diabetics

Conditions: Pre-diabetes; Diabetes; Obesity

Summary: the trial will test whether the alive multi-channel delivery health behavior program can positively affect weight and glucose level in pre-diabetics.


Eligibility criteria:
inclusion criteria: * at least one measurement in past 2 yrs of fasting plasma glucose of 100-125 mg/dl or impaired glucose tolerance * at least one measurement of body mass index (bmi) \>=27 in the past two years * age 40-79 * no use of diabetes medications within the past two years * member of kaiser permanente of northern california (kpnc) for at least 2 years * live in a 25 mile radius of the kpnc research clinic in oakland, ca exclusion criteria: * comorbidities that would contraindicate the gradual adoption of light/moderate physical activity, such as a recent cardiovascular event, severe chronic obstructive pulmonary disease, advanced arthritis, or poorly controlled hypertension

Keywords: behavior change pre-diabetes prevention diabetes prevention hemoglobin a1c glucose physical activity nutrition email web obesity
hard and soft tissue dimensional change after consecutive extractions and unassisted socket healing in the esthetic zone

Conditions: Wound Heal

Summary: the goal of this observational study is to evaluate the post-extraction hard and soft tissue dimension changes in patients requiring consecutive extractions and unassisted socket healing in the anterior maxilla. the main questions it aims to answer are: * is significant alveolar ridge resorption observed at center sites after consecutive extractions * is significant alveolar ridge resorption observed at the interalveolar septum after consecutive extractions, are different extraction sites associated with significantly different bone resorption * is a thick or thin wall phenotype associated with the amount of bone resorption * is soft tissue thickness change associated with the corresponding location (extraction site or interalveolar septum) and post-extraction thickness of the bone * is the interdental papilla height significantly affected after extractions. participants will undergo consecutive (two) extractions and will be evaluated after subsequent unassisted socket healing for 8 weeks.


Eligibility criteria:
inclusion criteria: * 18+ years old * require consecutive (two) teeth replacement in the anterior maxilla * signed informed consent * no significant medical conditions * patients with healthy periodontal conditions or previously treated to controlled and stable conditions exclusion criteria: * general medical (american society of anesthesiologists, asa, class iii or iv) and/or psychiatric contraindications * pregnancy or nursing * any interfering medication such as steroid therapy or bisphosphonate therapy * uncontrolled diabetes * autoimmune diseases or inflammatory diseases affecting the intraoral tissues * radiation therapy to head or neck region
open vs. laparoscopic surgery for pediatric choledochal cyst

Conditions: Congenital Choledochal Cyst; Pediatric Surgery; Surgical Outcomes; Open Surgery; Laparoscopic Surgery

Summary: this is a retrospective cohort study designed to compare the outcomes of open surgery versus laparoscopic surgery in pediatric patients diagnosed with congenital choledochal cyst (ccc). the study includes children who underwent surgery at guangdong medical university affiliated hospital and guangzhou women and children's medical center between january 1, 2010, and september 1, 2024. the aim of this study is to evaluate and compare the surgical outcomes, including surgery duration, intraoperative blood loss, hospital stay, and postoperative complications (e.g., bile leakage and intestinal obstruction), between the two surgical approaches. the data collected from the patient records will be analyzed to identify factors influencing surgical outcomes and to guide future treatment decisions for ccc in pediatric patients.


Eligibility criteria:
inclusion criteria: pediatric patients diagnosed with congenital choledochal cyst based on preoperative imaging (e.g., ultrasound, computed tomography（ct）, or magnetic resonance cholangiopancreatography（mrcp)）. patients who underwent either open surgery (open cyst excision and roux-en-y hepaticojejunostomy) or laparoscopic surgery (laparoscopic cyst excision and roux-en-y hepaticojejunostomy) for the treatment of congenital choledochal cyst. informed consent for follow-up obtained from the patient's family or legal guardian. exclusion criteria: patients lacking one or more key outcome measures, including surgery duration, hospital stay, intraoperative blood loss, incidence of postoperative bile leakage, or incidence of postoperative intestinal obstruction. patients with incomplete clinical data, such as missing sex, age, or other essential demographic information. patients with coagulation disorders that may interfere with surgery or recovery. patients with severe comorbidities or immune system disorders that may complicate surgical intervention or recovery. patients who underwent non-surgical treatment (e.g., endoscopic procedures) for congenital choledochal cyst. pregnant patients or those who are breastfeeding (if applicable to your study population).

Keywords: congenital choledochal cys network meta-analysis robotic-assisted surgery laparoscopic surgery pediatric surgical outcomes
tacs for sensory motor recovery after stroke

Conditions: Motor Recovery

Summary: the overall goal is to investigate the effectiveness of a novel intervention - transcranial alternating current stimulation (tacs) for motor recovery in stroke survivors.


Eligibility criteria:
inclusion/exclusion criteria for stroke subjects inclusion criteria: 1. age between 18\~75 years old 2. ≥ 6 months post stroke, medically stable; 3. unilateral, single stroke (no restriction on type (ischemic or hemorrhagic) or volume (large or small) of stroke); 4. visible finger flexor activation/movement 5. the ability to give consent exclusion criteria: 1. patients with visual deficit/neglect; hearing or cognitive impairment; 2. patients that are currently adjusting tone alternating medications (e.g., baclofen), or 3. patients received botulinum toxin injection to the arm/fingers \<4 months, or phenol injections \<2 years; 4. patients with pacemaker, metal implants or supplemental oxygen; 5. patients who have musculoskeletal disorders, including pain in the affected side 6. women who are pregnant.

Keywords: tacs motor recovery
intravenous terbutaline to facilitate labor epidural catheter placement

Conditions: Labor Pain

Summary: labor pain is a major factor in making the placement of an epidural catheter difficult. the epidural, once in place and dosed, eventually decreases the parturient's pain. to achieve this goal as fast and safely as possible it would be helpful to have a parturient who can tolerate and co-operate with the placement of the epidural catheter. briefly stopping contractions, the cause of labor pain, could be the key to achieve this goal. this study will evaluate the safety, efficacy and duration of the drug terbutaline for this purpose.


Eligibility criteria:
inclusion criteria: * in labor * labor pain \>3 on visual analog scale (vas) exclusion criteria: * cardiovascular disease * preeclampsia * diabetes mel-litus * thyroid disease * current (outpatient) opioid medication * recent and / or current use of cocaine * seizure disorder * psychiatric disease * body mass index \>35 * preterm labor (\<37 weeks pregnant) * known allergies to any of the three study substances

Keywords: labor pain analgesia, epidural
obtaining undifferentiated cells from testis biopsy

Conditions: Azoospermia

Summary: the purpose of this study is to isolate and culture stem cell from adult human testicular biopsies for future transplantation in fertility preservation.

testicular biopsies were obtained from azoospermic patients as part of their diagnosis and work-up after obtaining a signed informed consent. a portion of each sample was mechanically dissected in pbs with 1% pen/strep. for enzymatic digestion samples were incubated with 0.5g/ml collagenase type 1a for 20min and triple select for 15min at 37ºc on a shaker and then filtered with 30µm and centrifuged at 1,000rpm. the pellets were seeded and incubated in embryonic stem cell media (hesc) with glial cell line-derived neurotrophic factor (gdnf 4ng/ml) for 5-7 days at 37ºc (1st culture). to identify and isolate sscs they were marked with cd49f antibody and facs sorted. positive cells were cultured in gelatine plates containing hesc media with leukaemia inhibitory factor (lif1000u/ml) (2nd culture).

Eligibility criteria:
inclusion criteria: -azoospermic patients
a safety and efficacy study of infliximab (remicade) in patients with moderate to severe active crohn's disease

Conditions: Crohn Disease

Summary: this is a study of infliximab (remicade) in subjects with crohn's disease

crohn's disease is a disease characterized by inflammation (the changes that happen when tissues in the body are injured) and ulceration (formation of pus) of the bowel. the purpose of this study is to investigate the safety and therapeutic effect of two different doses of an anti-tnfα (tumor necrosis factor) antibody (a protein) given multiple times compared to a single dose followed by placebo (inactive substance). the name of the antibody is infliximab (remicade) the goal of the study is to evaluate whether patients respond longer to a single dose of infliximab or to repeated doses of infliximab. subjects will receive an infusion of infliximab at week 0 followed by infusions of infliximab or placebo at weeks 2, 6, 14 and every 8 weeks until week 54. patients who lose response are eligible for additional infliximab treatment.

Eligibility criteria:
inclusion criteria: * men and women \>=18 years of age * diagnosis of crohn's * crohn's disease of at least 3 months duration, with colitis, ileitis, or ileocolitis, confirmed by radiography or endoscopy exclusion criteria: * local manifestations of crohn's disease such as strictures, abscesses, or other disease * surgery for bowel diversion with placement of a stoma within 3 months prior to beginning the study * positive stool culture

Keywords: crohn's disease
early rehabilitation of cancer patients

Conditions: Breast Cancer; Colorectal Cancer; Lymphoma; Prostate Cancer; Testicle Cancer

Summary: a life threatening disease such as cancer may lead to post traumatic stress disorder, and even when reporting low levels of side-effects from cancer disease and treatment, 80% report high levels of stress symptoms. the purpose of the present randomised controlled trial is to examine the psychosocial effects of a stress management intervention based on cognitive behaviour therapy and with focus on increased physical activity in patients with various cancer diagnoses using a stepped-care approach. when using a stepped-care approach it is possible to study the level and intensity of stress management intervention required to achieve increased well-being. a cost-utility analysis will also be performed. 300 adult patients with a recent diagnosis of breast-, colorectal- prostate, testicular cancer or lymphoma and scheduled for adjuvant and/or curative oncologic treatment at haukeland university hospital, will be consecutively included in the prospective intervention study. the patients will be randomized to intervention or control. in step 1, all patients in the intervention group (i-a) will receive 2 counselling sessions. patients who report clinically significant levels of stress, such as intrusive thoughts/avoidance behaviour (measured by impact of event scale) and/or worry and depressions (measured by hospital and depression scale) will be included in step 2 (i-b) and include another 4-7 counselling sessions. there will also be a focus on motivating to increase physical activity level. both the intervention (i) and control group (c) are allowed to take part in the common rehabilitation program with patient education and physical training. data will be collected with self-reported standardized questionnaires. objectively measures of physical activity level, sleep and daily energy expenditure are recorded with sensewear™ pro3 armband. measure point is at inclusion and than after 6 week, 4, 8, 12 and 24 month.


Eligibility criteria:
inclusion criteria: * newly diagnosed with breast cancer, * colorectal cancer, * lymphoma, * prostate cancer or testicle cancer and scheduled for adjuvant and/or curative treatment in the form of chemotherapy, radiation therapy and/or hormonal therapy at the department of oncology and medical physics, haukeland university hospital, (dept. of oncology) bergen, * residence in rogaland, hordaland and sogn and fjordane county council, * initial treatment for cancer exclusion criteria: * an ongoing psychiatric condition, * language deficiencies in norwegian, * surgery for prostate cancer (only applies for prostate cancer) patients), * men with breast cancer, * live in nursing homes, * previous cancer, * treated for cancer earlier, * already implemented oncological treatment, * not self-reliant
cognitive therapy to sustain the antidepressant effects of intravenous ketamine in treatment-resistant depression

Conditions: Depressive Disorder, Major

Summary: the goals of this study are: 1) to investigate the efficacy of combining ketamine with intensive cognitive behavioral therapy (cbt) to sustain the antidepressant effects of ketamine; and 2) to determine ketamine's delayed effects on learning and memory, and to explore the relationship between any ketamine-induced changes in learning and memory and duration of antidepressant efficacy, with and without cbt augmentation. subjects with a diagnosis of mdd who are treatment-resistant to at least 2 antidepressants and have chosen to pursue clinical ketamine treatment at yale psychiatric hospital will be recruited for the study.


Eligibility criteria:
inclusion criteria: * suffering from a major depressive episode based on diagnostic and statistical manual (dsm) 5 criteria and having failed one or more standard antidepressant treatments during the current episode * hamilton depression rating scale (17-ham-d) score of 21 or more prior to ketamine treatment. * planned clinical treatment with ketamine at yale psychiatric hospital (yph) * as the purpose of this study is to determine the feasibility and efficacy of cbt to sustain the antidepressant effects of ketamine, only those who achieve a clinical response (i.e., 50% reduction in depression symptoms, as measured by the montgomery-asberg depressive rating scale (madrs) will be eligible for randomization. * patients must be treatment resistant to at least two drugs used to treat depression. exclusion criteria: * any axis i or axis ii disorder, which at screening is clinically predominant to their depressive episode or has been predominant to their depressive episode at any time within 6 months prior to screening * active suicidal thoughts with a plan * current or recent (\<6 months ago) substance use disorder * non-affective psychosis (such as schizophrenia or schizoaffective disorder) * inability to speak english fluently * a clinically significant abnormality on the screening physical examination that might affect safety, study participation, or confound interpretation of study results * dementia, delirium, or any other neurological or mental disease that might affect cognition or the ability to meaningfully participate in cognitive behavioral therapy (cbt).