Kornimate/medical-research-clean huggingface dataset:
the impact of low glycemic index nutritional shake on glucose regulation in overweight and obese adults

Conditions: Hyperglycemia; Obesity Prevention

Summary: low glycemic index nutritional shakes have clinically shown to improve post-prandial glycemic responses in acute laboratory control studies. however, there is limited information on how replacing meals with low-glycemic index shake could impact glucose regulation in free-living adults consuming their own diets. the present study aims to examine the impact of adding the sp glucose-assist shake to the breakfast of non-diabetic overweight and obese adults. subjects: 40 non-diabetic adults aged 25-65 years and body mass index ranging between 25-39 . protocol: this is going to be a three-week study that will include a one-week self-selected diet, followed by two weeks of a breakfast supplement shake (standard process glucose assist) or control cereal oat breakfast.


Eligibility criteria:
inclusion criteria: * body mass index 25-40 * eating pattern 3 meals a day * stable weight for the last 2 months (\<5 pounds fluctuation) * willing to eat oat cereal for breakfast * glycated hemoglobin \<7% exclusion criteria: * glycated hemoglobin \>7% * body mass index ≤25 or ≥ 40 * night shifting work * atypical meal pattern (not three meals a day or intermittent fasting) * thyroid medication * bariatric surgery * habitual strenuous exercise * commuting by bicycle * eating disorders * use of aspirin during the duration of the study * intake of vit c \>60 mg/day during the study * cancer * cardiovascular disease * renal disease * hepatic disease * x-ray, mri or ct appointment during the study duration * current infection requiring medication * chronic, contagious, infectious diseases such as tuberculosis, hepatitis a, b, c, or hiv * medications of supplements that could affect body weight or appetite (i.e. ozempic) * participating in another study at the same time

Keywords: meal replacement glucose regulation
comparison of a new patient warming system using polymer conductive warming with forced air warming during surgery

Conditions: Hypothermia

Summary: two patient warming systems will be compared with 40 patients each in a convective warming group (bairhugger, arizant) and in a conductive warming group (hotdog, augustine biomedical). the patients will undergo small to medium trauma surgery and will be warmed with the randomized device - the hypothesis is, that the area under the standardized core temperature / time curve is significantly greater in the conductive warming group. secondary outcome is the mean skin temperature / time area under the curve.

general study design we will study 200 patients (18-90 years) undergoing elective orthopedic surgery at the trauma surgery unit. the patients must have normal weight (20-30 bmi), the duration of surgery should last between 3 - 4 hours. there will be no other exclusion criteria (except severe peripheral arterial disease in the warmed extremity), as forced air patient warming is routinely used for all patients during this procedure. the patients will be randomly assigned via a computer generated randomization list to treatment with either polymer or forced air warming. anaesthesia and fluid management will be administered as desired by the anaesthesiologist. before warming four skin temperature probes will be attached to the upper arm, chest, abdomen and back of the patients to calculate mean body temperature. a probe (mallinckrodt anesthesiology products, inc., st. louis, mo) will be introduced in the ear to measure core temperature. afterwards, treatment with bairhugger or hotdog will be started. the measurements will be recorded every five minutes until the end of surgery when intraoperative warming is stopped. differences between core temperatures will be analyzed both by using the summary measure of auc (area under the curve) and by comparing the core-temperature at the end of surgery in the polymer and the forced air group with two-tailed, unpaired t tests if normally distributed and with a wilcoxon test, if not normally distributed (distribution tested by k-s-test). results are expressed as means ± standard deviations if normally distributed, as median (iq-range) when not normally distributed. differences will be considered statistically significant when p \< 0.05. we consider a difference in core temperature at the end of surgery of 0.5°c as clinically important. considering this difference as well as a known standard deviation of approximately 1.5°c we will have to study 40 patients in each arm of the study to achieve statistical significance using a power of 90% and a p-value of 0.05.

Eligibility criteria:
inclusion criteria: * the patients must have normal weight (20-30 bmi), the duration of surgery should last between 3 - 4 hours. * there will be no other exclusion criteria , as forced air patient warming is routinely used for all patients during this procedure. exclusion criteria: * severe peripheral artery disease in the warmed extremity

Keywords: patient warming convective warming conductive warming intraoperative normothermia accidental hypothermia intraoperative hypothermia
return to work among patients with stress related mental disorders - an intervention in the swedish primary care

Conditions: Stress, Psychological; Burnout, Professional; Adjustment Disorders

Summary: the aim of this project is to develop a model for return to work (rtw) for patients sick listed due to stress related mental disorders, which takes into account each patient's specific situation; includes the workplace, and is well adapted to the swedish primary care setting. in late 2016, general practitioners (gps) and rehabilitation coordinators at both public and private primary care centers will be offered a one-day training about work and workability for patients with stress related mental disorders. also, the participants will be trained in a specific method that includes the patient's employer early in the rehabilitation process the project has a quasi-experimental and longitudinal design. the intervention will be conducted on 15 different primary care centers, which will be matched with a comparison group. return to work for 500 patients will be analyzed using registry data, 6, 12 and 18 months after sick-listing. the hypothesis is that patients who are sick-listed at primary care centers that completely or partially implemented the specific method on average will return earlier to work than patients sick-listed at primary care centers that did not implement the method. alongside studying if the intervention has an effect on the patients' rtw over time, the investigators aim to investigate the mechanisms explaining the effects and the individual and organizational level (primary care units) circumstances necessary for these mechanisms to be triggered. to gain deeper knowledge about mechanisms and context, the investigators will conduct interviews with the treatment staff and collect registry data about the primary care units.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of international classification of diseases (icd)10 f43 * has an employment * good command in spoken and written swedish exclusion criteria: * participants must not have been on long term sick-leave (\>60 days) during the last three years, regardless of causative diagnosis.

Keywords: exhaustion disorder
stepwise shock wave lithotripsy in pediatric urolithiasis

Conditions: Pediatric Urinary Lithiasis

Summary: to evaluate and compare the results of conventional and stepwise shock wave lithotripsy treatment modalities in pediatric urinary lithiasis.

between march 2008 and february 2012, 81 patients were randomized and included in this study. shock wave lithotripsy was performed by using a dornier compact delta instrument. localizations of radiopaque and non-opaque stones were estimated by using flouroscopy and ultrasonography, respectively. treatment energy was set on 13 kv in the conventional group. in the stepwise group, treatment energy was initially set on 10 kv and gradually increased up to 13 kv per 250 shocks. the maximum numbers of shocks in both groups were limited to 3000. patients were followed up with 15 days interval. in each visit, patients were respectively questioned for pain, hematuria and history of stone passage. in case of treatment failure, shock wave lithotripsy was repeated.

Eligibility criteria:
inclusion criteria: the patients with pediatric urinary lithiasis. exclusion criteria: resistant urinary tract infections coagulopathies anatomically obstructed urinary system
efficacy of pf-04531083 in treating post-surgical dental pain

Conditions: Post-surgical Dental Pain

Summary: the purpose of this study is to evaluate the overall pain relief of a single dose of pf-04531083 against placebo following third molar extraction.


Eligibility criteria:
inclusion criteria: * oral surgical procedure having removed 2 third molars (unilateral). * pre-dose pain intensity score (100 mm visual analog scale \[vas\]) \>50 mm within 5 hours of oral surgery. * pre-dose pain intensity score of moderate or within 5 hours of oral surgery. exclusion criteria: * presence or history of any significant hepatic, renal, endocrine, cardiovascular, neurological (including subjects with a history of frequent moderate to severe headaches or subjects with episodic migraines more than twice per month), psychiatric, gastrointestinal, pulmonary, hematologic, or metabolic disorder. * prior use of any type of analgesic or nsaid within five half-lives of that drug or less before taking the first dose of study medication, except for anesthesia for the procedure. * recent history of chronic analgesic or tranquilizer dependency. * active dental infection at the time of surgery. * any significant oral surgery complication at the time of surgery or in the immediate postoperative period or dental surgery lasting \> 30 minutes. * subjects who are smokers.

Keywords: post-surgical dental pain
effects of acupressure at sanyinjiao point on primary dysmenorrhea among university students.

Conditions: Primary Dysmenorrhea; Acupuncture

Summary: the goal of this non-invasive interventional study is to explore the university students' experience of living with primary dysmenorrhea and evaluate the effect of acupuncture at the sanyinjiao point on their physiological discomfort. the main questions it aims to answer are: * is there any difference in pain before and after the intervention of the sanyinjiao point acupressure for dysmenorrhea among female college students? * is there any difference in the average number of menstrual distress questionnaire scale before and after sanyinjiao acupressure in female college students with dysmenorrhea? participants will be acupressure at sanyinjiao point triple times during the study.

this study will employ a quasi-experimental research design, using pre- and post-intervention surveys in intervention. in the universities of central taiwan as a place to collect cases. target 50 university students with primary dysmenorrhea will be recruited by using a purposive sampling. after taking the informed consent and basic information of the study participants, the observation will be measured before and after the intervention of the sanyinjiao point acupuncture, which were performed during two consecutive menstrual cycles (eight days per cycles). the data collection will be obtained by demographic questionnaire, the visual pain scale (vas) and the menstrual physiological infrequency table (mdq). descriptive statistics (mean, standard deviation (sd), frequency, mean difference), chi-square test and anova statistical testswere used for data analysis.

Eligibility criteria:
inclusion criteria: a. dysmenorrhea in the past six months, lower abdominal pain one or two days before menstruation or the first and second day of menstruation. b. dysmenorrhea will affect women's daily life, and those whose vas score is greater than 5 points are female college students with moderate to severe pain. c. the menstrual cycle is 21-35 days, and menstruation lasts 3-7 days. d. female college students aged 18\~30 exclusion criteria: a. pregnant women or women who have given birth, breastfeeding, taken contraceptives, and have contraceptive devices. b. previous uterine or pelvic surgery, severe uterine and pelvic infection. c. have a major disease: cancer, heart disease, hyperthyroidism, etc. strong pain will affect the performance of menstrual pain and other diseases. d. there is wound, inflammation or skin damage on the skin of sanyinjiao acupoints on both sides. e. use of traditional chinese medicine for dysmenorrhea in the past three months.

Keywords: sanyinjiao acupoint dysmenorrhea
to demonstrate the relative bioavailability of diclofenac sodium 50 mg enteric-coated tablets under non-fasting conditions

Conditions: Inflammation

Summary: to demonstrate the relative bioavailability of diclofenac sodium 50 mg enteric-coated tablets under non-fasting conditions.


Eligibility criteria:
inclusion criteria: * no clinically significant abnormal finding on physical exam, medical history, or clinical laboratory results on screening. exclusion criteria: * positive test results for hiv or hepatitis b or c. * treatment for drug or alcohol dependence.

Keywords: anti-inflammatory
comparison of two types of face mask ventilation in obese patients

Conditions: Obesity, Morbid

Summary: two types of face masks : cuffed and uncuffed were evaluated for artificial ventilation in obese patients. after induction to anesthesia patients were ventilated with both types of masks using anesthesia machine with the same settings: tital volume of 500 ml, respiratory rate of 12/min. the inspired and expired volume was measured using anesthesia machine volumeter, the difference between inspired and expired volume was counted. the comparison between two types of masks was performed taking into consideration several parameters: type of obesity, gender, age.

the aim of the study was to determine which of the tested: cuffed or uncuffed face masks allows better replacement ventilation in obese patients. the study was conducted on patients with the bmi over 39 kg/m2 patients qualified for bariatric surgery were selected for this study according to the order of reporting to the surgery department. the study adopted a simplified assumption that the gynoid type of obesity most often concerns women, and the android type, i.e. abdominal obesity, most often affects men. two face masks were used to compare the effectiveness of replacement ventilation: the cuffed and uncuffed . it was randomly chosen (by tossing a coin) which face mask would be used first. the induction of anesthesia was low-opioid, the patients were placed in the supine position with the head and trunk elevated by 25 degrees on a positioning pad. 100% oxygen concentration was used for active pre-oxygenation, the test mask was applied with one hand using the ec clamp technique. the masks were changed after four consecutive measurements for each type of mask. in order to objectify the measurement with the same tidal volume, a respirator was used with the same settings: tidal volume of 500 ml and respiratory rate of 12/min. sealing was measured by comparing the inspired volume with expired volume, that is the amount of leakage generated by individual masks was assessed. the obtained data were analyzed with the kolmogorow-smirnov test and supplemented with the values of the wilcoxona test.

Eligibility criteria:
inclusion criteria: * obesity * scheduled for elective surgery under general anesthesia exclusion criteria: * predicted difficult intubation * predicted difficult face-mask ventilation

Keywords: morbid obesity face mask ventilation
immersive vr for female orthopaedic rehabilitation

Conditions: Hip Arthropathy

Summary: this study compares the effects of cardiological rehabilitation enhanced with virtual reality (vr) versus conventional rehabilitation methods. it assesses the impact on both psychological parameters (including depression, stress, anxiety, and kinesiophobia) and physiological and functional parameters of cardiology patients. the aim is to analyze the efficacy and benefits of vr-supported rehabilitation in improving patients' mental and physical health compared to traditional methods.

the study will involve elderly female patients aged 60 and above who present sequentially at the rehabilitation department of st. hedwig of silesia hospital in trzebnica (poland) within three months following hip joint arthroplasty surgery. participants will be randomly assigned to one of two groups: group a, the virtual reality group, will receive 8 therapy sessions, with two sessions per week; group b, the control group, will undergo conventional rehabilitation.

Eligibility criteria:
inclusion criteria: * female individuals who have recently undergone hip joint arthroplasty surgeries aged 60 years and above. exclusion criteria: * cognitive impairments that prevent independent completion of research questionnaires * reported consciousness disorders * bipolar affective disorder and other serious mental disorders in the patient's medical history * use of psychoactive drugs * ongoing psychiatric treatment or individual psychological therapy * contraindications to virtual reality such as epilepsy, vertigo, serious vision disorders * functional status preventing independent movement (orthopedic aids are allowed, e.g., crutches, walker) * refusal to participate in the study at any stage

Keywords: virtual reality arthroplasty women depression
becaplermin use and cancer risk in a patient population of u.s. veterans with diabetes

Conditions: Diabetes Mellitus; Foot Ulcer; Diabetic Foot; Diabetic Neuropathies

Summary: the purpose of this study is to evaluate risk of cancer incidence and mortality associated with the use of regranex (becaplermin) in patients with diabetes who are members of a u.s. veterans health administration.

this is an observational study of patients with diabetes who are eligible for care through the national department of veterans affairs health care system (va), representing the largest sample of older adults in an integrated health care system in the u.s. with comprehensive electronic medical records and linkable health survey data. regranex (becaplermin) is topical medication used to treat lower extremity diabetic neuropathic ulcers. va patients with diabetic foot ulcers who have no prior history of cancer who have received treatment with becaplermin will be compared to a group of similar patients who have not received treatment with becaplermin. becaplermin users (from the time of initial dispensing of becaplermin) and becaplermin nonusers will be followed forward in time for up to 8 years to identify new cancers and cancer related deaths, with confirmation of cases through registries and medical chart review. this is an observational study; no investigational drug will be administered.

Eligibility criteria:
inclusion criteria: * patients with diabetic foot ulcers who are members of the u.s department of veterans affairs health care system (va) exclusion criteria: * history of cancer (including nonmelanoma skin cancer) prior to study entry

Keywords: regranex (becaplermin) platelet-derived growth factor bb cancer cancer incidence cancer mortality lower extremity diabetic neuropathic ulcer
effects of flutamide on insulin and glucose metabolism in women with polycystic ovary syndrome

Conditions: Polycystic Ovary Syndrome

Summary: polycystic ovary syndrome (pcos) is the major cause of infertility in the united states. many women with pcos demonstrate insulin resistance and a compensatory hyperinsulinemia.this is due to both an intrinsic form of insulin resistance unique to pcos and, in many cases, acquired insulin resistance due to obesity. the importance of this observation lies in the fact that hyperinsulinemia appears to play an important pathogenetic role in the hyperandrogenism and anovulation of both obese and lean women with pcos.

hyperinsulinemia stimulates ovarian production of androgens, especially testosterone, in pcos. therefore, it is theoretically possible that testosterone increases urinary clearance of d-chiro-inositol (ucl(dci) in pcos, and that this serves as the explanation for the correlation between ucldci and insulin sensitivity. while we regard this possibility as unlikely, it is important that it be tested. to accomplish this, we will assess obese (body mass index (bmi) \>30 kg/m2) women with and without pcos at baseline, and again after 4 weeks of androgen action blockade with the drug flutamide. flutamide is an antiandrogen that works by blocking the binding of androgens to the androgen receptor. we will determine if this pharmacologic blockade i) decreases the renal clearance of dci, ii) increases the circulating concentration of dci, and iii) enhances the insulin-stimulated release of the d-chiro-inositol-containing inositolphosphoglycan (dci-ipg) mediator during an ogtt.

Eligibility criteria:
inclusion criteria: (1) obese (bmi≥30 kg/m2) women with pcos between 18-40 years of age: i) oligomenorrhea (8 menstrual periods annually), ii) biochemical hyperandrogenemia (elevated total or free testosterone), iii) normal thyroid function tests and serum prolactin, and iv) exclusion of 21α-hydroxylase deficiency by a fasting 17α-hydroxyprogesterone \<200 ng/dl.48, (2) acceptable health on the basis of interview, medical history, physical examination, and laboratory tests (complete blood chemistry (cbc), complete metabolic panel (cmp), urinalysis, serum beta-human chorionic gonadotropin (bhcg)). (3) signed, witnessed informed consent. (4) ability to comply with study requirements. exclusion criteria: (1) diabetes mellitus by fasting glucose or oral glucose tolerance test (ogtt), or clinically significant pulmonary, cardiac, renal, hepatic, neurologic, psychiatric, infectious, neoplastic and malignant disease (other than non-melanoma skin cancer). (2) current use of oral contraceptives. (3) documented or suspected recent (within one year) history of drug abuse or alcoholism. (4) ingestion of any investigational drug within two months prior to study onset. -

Keywords: pcos