Kornimate/medical-research-clean huggingface dataset:
natural history of chronic urticaria

Conditions: Chronic Urticaria

Summary: the purpose of this study is to examine the natural history of chronic urticaria in children and to identify the predictors for chronic urticaria remission.

a prospective cohort study of 92 children who were diagnosed with chronic urticaria to investigate the natural course of chronic urticaria and to identify predictors of disease remission.

Eligibility criteria:
inclusion criteria: * children 4-15 years of age with the diagnosis of chronic urticaria who were attending the pediatric allergy clinic, siriraj hospital mahidol university, thailand, from march 2003 to march 2009. exclusion criteria: * children who had isolated physical urticaria, inability to be followed up, pregnancy, underlying diseases such as cardiovascular, hepatobiliary, and renal diseases.

Keywords: chronic urticaria natural course remission
home based exercise for patients with breast or prostate cancer (the benefit-ca study)

Conditions: Breast Cancer; Prostate Cancer

Summary: the purpose of this trial is to evaluate the feasibility of a home based exercise program for individuals with breast or prostate cancer patients undergoing active treatment.

this feasibility trial aims to assess a home-based exercise program, including a 3-month intervention of structured physical activity and health education for individuals with breast or prostate cancer. the main objective of this trial is to assess the adherence of cancer patients to a program of structured exercise, mixed with a health education approach, implemented and accompanied in a remote approach. the data collection will include variables related to: (a) recruitment and retentions rates; (b) attendance to exercise sessions; (c) fatigue and quality of life levels; (d) functional capacity levels; (e) adverse events related or not to the study; (f) patient selected outcomes.

Eligibility criteria:
inclusion criteria: * eighteen years old minimum; * be living in porto alegre or metropolitan region; * breast cancer stage 0 - iii or * localized prostate cancer; * undergoing hormonal treatment / manipulation in isolation or combined with other therapies three months prior to the entrance in the study; * hormonal therapy / manipulation planned to be active throughout the study duration; * not engaged in any exercise training for more than once a week for the past 6 months; * in case of previous surgical procedure, the patient must have medical clearance at the moment of the contact to begin the study or be cleared to do so in the near future (up to two weeks). exclusion criteria: * metastatic phase / progression of the disease or active regional location prior to beginning of the study; * inability to understand the terms and conditions of study due to language, hearing, cognitive or severe psychiatric issues; * another family member, who lives at the same residence, participating in the study; * planning to move or major absence (more than two weeks) during the study; * history of cardiovascular disease (except controlled hypertension) or severe cardiopulmonary disease, as well as history of heart attack, revascularization procedures, profound venous thrombosis, encephalic vascular accident (brain stroke) or pulmonary embolism in the past twelve months; * chronic pulmonary disease that requires oxygen or corticosteroid therapy; * kidney disease with or that is going to begin the use of dialysis or waiting for a kidney transplant; * severe nausea, anorexia or any other condition which does not allow to perform physical exercise; * medical contraindication to exercise training.

Keywords: cancer feasibility trial physical activity home based exercise trial adherence
phenylephrine versus ephedrine in pre-eclampsia

Conditions: Pre-eclampsia

Summary: phenylephrine administration is associated with reductions in co and scto2 compared with ephedrine when used for blood pressure management in women with pre-eclampsia undergoing cesarean delivery under spinal anesthesia.


Eligibility criteria:
inclusion criteria: * english speaking * age ≥18 yrs * pre-eclampsia (mild, or severe) * non-laboring women * cd under spinal anesthesia exclusion criteria: * height \< 5'0" * allergy to phenylephrine or ephedrine, or any other standardized medication * severe cardiac disease in pregnancy with marked functional limitations (nyha class iii and iv) * patients on monoamine oxidase inhibitors or tricyclic antidepressants * history of recent amphetamine or cocaine use. * subject enrollment in another study involving a study medication within 30 days of cd * any other physical or psychiatric condition which may impair their ability to cooperate with study data collection

Keywords: cesarean delivery spinal anesthesia
evaluation of brain functional changes with 18f-fdg pet and cognitive processes after brain radiotherapy for cavernous sinus meningiomas and non-secreting acth adenomas

Conditions: Meningioma

Summary: the use of radiotherapy for irradiation of all or part of the brain, in the treatment of extracerebral intracranial neoplasms, is growing rapidly, both due to the increase in diagnoses of primary tumors thanks to new imaging methods, and for the increase in the number of new cases of cancer. cerebral neurotoxicity linked to radiation treatment is an adverse effect that is not always accurately evaluated based on the prognosis of some brain pathologies. the progression of diagnostic and therapeutic methods has recently generated a modification of therapeutic protocols and some categories of radiotreated patients may incur acute, subacute and late effects. these include manifestations of acute neurological deterioration, more frequently effects classified as sub-acute such as "somnolence syndrome" (from 2 to 6 weeks after the end of treatment) and finally late effects, which manifest themselves as a variety of neurological deficits in particular a decline in cognitive brain functions, probably linked to a direct effect on neurons or the result of an imbalance in the connections between white matter and cerebral gray matter. in relation to the myelin function of conduction of axonal transmission, the result of radio-induced damage in this site would manifest itself with a significant reduction in the speed of transmission of the impulse and consequently with a dramatic worsening of cognitive processes. in particular, clinically, radiologically and in some cases also from a pathological point of view, the damage from rays on the brain parenchyma would have aspects similar to those of a degenerative pathology such as alzheimer's disease. these effects are usually measured on the patient by subjective assessments or using neuropsychological tests. the use, not only experimental, of neurophysiological methods for the study of cognitive processes in neurology and in degenerative disorders such as dementia is increasingly frequent. these methods are based on the study of specific neuronal circuits involved in the cognitive functions of the human brain in normal conditions and in the presence of pathology. among the techniques that allow an analysis of molecular alterations in vivo there are scintigraphic ones, i.e. nuclear medicine ones, including single photon emission tomography (spet) and positron emission tomography (pet).


Eligibility criteria:
inclusion criteria: * lesion dimensions compatible with a gamma knife treatment or tomotherapy; * adequate hematological, hepatic and renal function; * signed informed consent. exclusion criteria: * patients \< 18 years
effectiveness and implementation of a digital intervention for pediatric chronic pain co-designed with patients

Conditions: Chronic Pain

Summary: children and adolescents with chronic pain often lack a proper diagnosis and treatment. research has shown that, if left untreated, it usually doesn't resolve and continues through adulthood. the goal of this multi-phase study is to co-develop (with patients), test, and implement a smartphone app called "digital solution for pain in adolescents" (digital spa) which can provide pain management resources to children with chronic pain and their parents, preventing future disability. participants will: participate in individual and group interviews, respond to questionnaires online and try a smartphone app (adolescents) or a website (parents).

phase 1) focus groups with patients, parents and clinicians (n = 5-6 each) will inform about unmet pain care needs, and provide a starting point for co-designing the intervention. phase 2) content creation and usability testing will be based on the results of phase 1 and the theory-driven development will follow the latest available evidence and the world health organization guidelines on the management of chronic pain in children. the intervention will use validated psychological techniques (particularly cognitive behavioral therapy and acceptance and commitment therapy) focused on improving functioning by teaching pain coping skills, such as: relaxation, goal setting, sleep management, behavioral activation, self-management of negative thoughts and emotions, and communication skills. phase 3) effectiveness and implementation study. participants (n = 195) will be adolescents 12-17 years old with chronic pain admitted into any of 6 large hospitals in spain and one of their parents.

Eligibility criteria:
inclusion criteria: * adolescents age 12-17 years * has had non-oncologic chronic pain for at least 3 months (e.g., abdominal pain, headache or musculoskeletal pain) * has internet access * one parent is willing to participate (and both give consent for their child to participate) exclusion criteria: * diagnosis of a comorbid serious health condition (e.g., cancer) * parent or child does not speak or read spanish * active psychosis or suicidal ideation

Keywords: chronic pain adolescents digital health psychological intervention co-development implementation
evaluation of the prostaplant prostate stent insertion in ex vivo human prostate

Conditions: Benign Prostatic Hyperplasia

Summary: the purpose of this ex-vivo study is to evaluate the insertion procedure for the prostaplant implant in human prostates and the support that it supplies to the prostate.


Eligibility criteria:
inclusion criteria: * males, * 18 years old and up, * suffer from bph, * candidate for radical prostatectomies exclusion criteria: * according to the physician's decision

Keywords: bph prostate stent benign prostatic hyperplasia (bph)
evaluation of periodontal treatment in patients with bronchiectasis

Conditions: Bronchiectasis; Periodontal Disease

Summary: background: association between periodontal disease (pd) and chronic obstructive pulmonary disease (copd) has been widely studied and the aspiration of periodontal pathogens is one of the most accepted causal mechanisms for pulmonary exacerbation. bronchiectasis is clinically quite similar with copd, including chronic administration of antibiotics, increased systemic inflammation and relatively similar clinical symptoms, but for the time being; there are no studies that have correlated this condition to pd. this study will evaluate if the scaling and root planning (srp) associated with photodynamic therapy improves periodontal clinical parameters, halitosis, and the quantity of microorganisms associated with exacerbation of bronchiectasis in saliva, subgingival periodontal microenvironment, sputum and nasal lavage at baseline, after 3 months and one year of srp. methods/design: ninety patients with chronic periodontal disease and bronchiectasis will be enrolled in the study and they will be treated as follow:g1 control (n = 30) - supragingival scaling (ss) and dental hygiene orientation (dho); g2 experimental (n = 30) - srp + dho; g3- experimental (n = 30) - srp + pdt + dho. the quantification of bacterial groups commonly associated with exacerbation of bronchiectasis (p aeruginosa, s. aureus) and periodontal diseases (p. gingivalis), will be evaluated in periodontal pockets, saliva, nasal lavage and sputum by quantitative pcr at baseline 3 months and one year after the srp. g1 patients will receive srp upon completion of the investigation. if the mean depth of probing of this group worsen (\> 1mm) at 3 months they will be excluded from the study, treated (srp) and the data will be described. discussion: the results of this protocol will determine the efficacy of periodontal treatment in decreasing the total amount microorganisms in saliva periodontal pocket, sputum and nasal lavage, the most probable niches of bronchiectasis exacerbation, and reducing local inflammation and halitosis after 3 months and one year. it is expected an higher improvement in all parameters measured over 3 months and 1 year for g3


Eligibility criteria:
inclusion criteria: * patients must have \> 35 years, both genders, \> 10 teeth with chronic moderate generalized periodontal disease , i.e. more than 30% of teeth examined with ≥ 4 mm probing depth. exclusion criteria: * exclusion criteria include smokers or former smokers for less than five years, pregnant, people with cystic fibrosis and asthma, phenytoin or cyclosporine users (because they affect periodontal status), decompensated systemic diseases requiring prophylactic antibiotic therapy for periodontal treatment, who used oral antiseptics or anti-inflammatory in the last 3 months, or periodontal treatment performed in the last 6 months.

Keywords: microbiology halitosis
evaluating the safety and efficacy of 177lu-lnc1011 injection in a single-center, single-arm, open study in patients with prostate-specific membrane antigen (psma)-positive metastatic desmoplasia-resistant prostate cancer

Conditions: PSMA PET-Positive Castration-Resistant Prostate Cancer

Summary: evaluating the safety and antitumor efficacy of 177lu-lnc1011

this is a prospective, single-center, single-arm, open iit clinical study evaluating the safety and anti-tumor efficacy of 177lu-lnc1011 injection in patients with psma-positive metastatic desmoplasia-resistant prostate cancer (mcrpc). thirteen patients are expected to be enrolled. subjects will be required to sign an informed consent form prior to screening, and successful screened subjects will be treated with 177lu-lnc1011 injection as 75 mci (2.78 gbq) intravenously every 6 weeks for a total of no more than 6 doses during the treatment period. subjects will be monitored for safety and anti-tumor efficacy after dosing during the treatment period.

Eligibility criteria:
inclusion criteria: 1. ≥18 years old, male. 2. histologically or cytologically defined prostate cancer, the patients have not been treated or have exhausted all treatment. 3. meet the prostate cancer working group 3 (pcwg3) diagnosis of metastatic desmoplasia-resistant prostate cancer (mcrpc), including: a) the presence of a desmoplasia level of serum testosterone (serum testosterone \ 1 ng/ml and 2 consecutive rises in psa 1 week apart, 2 greater than 50% of the nadir; or a bone scan suggestive of ≥2 new bone lesions; or ct or mri suggestive of progression of soft tissue lesions (recist 1.1). 4. a physical status score of ≤2 according to eastern cooperative oncology group (ecog) criteria. 5. psma positivity confirmed by 68ga -psma pet/ct. exclusion criteria: patients who did not meet the requirements as assessed by the investigator.

Keywords: psma mcrpc prostate cancer
a comparison between two laparoscopic techniques in management of inguinal hernias in pediatrics

Conditions: Inguinal Hernia; Pediatrics

Summary: to compare between the use of the percutaneous internal ring suturing (pirs) technique and the laparoscopic intraperitoneal purse-string suture sac closure technique. in pediatrics \& evaluate the safety, efficacy feasibility ,operative time ,postoperative pain ,recurrence rate of both approaches.

inguinal hernia repairs (ihrs) are one of the most common procedures performed by pediatric surgeons around the world. although the open method remains the most common for pediatric ihr, laparoscopic ihr has increased dramatically between 2009 and 2018. over a dozen different laparoscopic techniques have been developed .with the rise in popularity of laparoscopic ihr, many researchers have set out to examine the differences in efficacy of open ihr compared with various laparoscopic ihr techniques. however, there are few studies directly comparing different laparoscopic techniques. by determining outcome discrepancies among popular laparoscopic techniques for pediatric ihr, we can help improve surgical techniques, postoperative outcomes, and patient satisfaction.the proposed advantages of the laparoscopic approach include visualization of a contralateral ppv, identification of less common (direct, femoral, pantaloon) hernias ,diminished postoperative pain, more rapid return to normal function, and improved cosmesis. two laparoscopic techniques that have gained popularity among pediatric surgeons in the past decade, the percutaneous internal ring suturing (pirs) technique and laparoscopic intraperitoneal purse string suture sac closure technique.

Eligibility criteria:
inclusion criteria: * 1. age 1month to 18 years. 2. denovo inguinal hernias. 3. uncomplicated inguinal hernias. exclusion criteria: * 1. complicated inguinal hernia 2. age more than 18 years 3. cases inwhich laparoscopic surgery is contraindicated 4. cases with collagen disease. 5. recurrent inguinal hernia.

Keywords: laparscopic inguinal herniotomy
effectiveness of kinesiotaping and manipulation therapies in drooling management among children with oral dysphagia

Conditions: Drooling

Summary: children suffering from neurological problems may have a common problem of drooling and dysphagia.there is high prevelance of neurological disorders in developing countries including pakistan.parents of children with disability are highly stressed and burdenised while taking care of their children.there is a need to overcome the drooling and dysphagia problems with effective interventions.

there is no clear consensus that which interventions are safe and effective and hard to decide about the effective intervention for drooling management. this will help the parents, therapist and children to manage their feeding problems effectively, hence improve quality of life of parents and children.there is also scarcity of well designed randomized controlled trails and limited published literature on the usefulness of the kinesiotape for management of drooling in children with oral dysphagia, this study will be conducted in an attempt to evaluate the same. there is also a lack of comparative studies to evaluate the effectiveness of traditional oral motor therapies and kinesiotaping therapy. speech pathologists and help them in managing drooling effectively by using the best effective therapeutic approach. this study will also add up evidence-based knowledge to existing literature

Eligibility criteria:
inclusion criteria: * • both male and female children with different non degenerative neurological disabilities ( cerebral palsy, traumatice brain injury, childhood stroke) and having oral phase dysphagia. * age between 3-15 years. * those who will have drooling severity rating of ≥ 4 on modified teacher's drooling scale. * child who can comprehend simple verbal commands and on 3 words sentence level speech * have good head control. * parents and care givers of children with drooling and oral phase dysphagia will also be included in the study exclusion criteria: * those children who would have structural abnormality of respiratory system. * corrected or uncorrected cleft palate or cleft lip. * wounds around the lips. * recent surgery, and medication or on any treatment to control drooling would be excluded from the study.

Keywords: dysphagia, drooling, kinsesiotaping therapy, manipulation therapy
establishment of a parathyroid tissue bank

Conditions: Parathyroid Disease

Summary: to develop a tissue bank library for patients with parathyroid disease who have undergone surgery and/or biopsy, and/or who may undergo surgical intervention at m. d. anderson cancer center or outside centers, and/or all patients seen through the parathyroid center at participating sites, whether or not the patients undergo treatment for their disease. the tissue bank will contain both normal parathyroid tissue and diseased tissue, and will provide a resource for the ongoing study of parathyroid disease and management.

fresh residual tissue samples will be obtained during parathyroid and/or pancreas tumor intervention (for pancreas tumor intervention in men1 patients with hyperparathyroidism and pancreatic lesions). in addition, outside paraffin tissue blocks or slides will be requested from patients presenting to mdacc, or to participating family members who have had prior surgery outside of md anderson. forty cubic centimeters (40 ccs) of whole blood will be obtained from individuals for peripheral blood lymphocyte, plasma, and serum separation and analysis per event. collections may be made at any or all of the following timepoints: preoperatively, during intervention, and/or at subsequent follow-up visits for up to fifteen years.

Eligibility criteria:
inclusion criteria: 1. eligible participants will include patients presenting at md anderson cancer who are scheduled for surgical treatment of parathyroid disease and/or patients with men1, and/or those presenting with hyperparathyroidism and/or pancreatic lesion, who are scheduled for pancreas tumor intervention, as well as patients having had surgery and who have had residual tissue stored under lab02-518, lab03-0320 or prior front door consents, or who have had surgery at other centers and provide signed authorization to obtain the tissue from the outside institution. 2. in addition, eligible participants may include family members of md anderson patients who have been diagnosed with parathyroid disease and who have had surgery at other centers, and who provide a signed authorization to obtain the tissue from outside facilities and/or who begin care at md anderson and will be having intervention at md anderson. exclusion criteria: n/a

Keywords: parathyroid disease parathyroid tissue bank database blood samples