Kornimate/medical-research-clean huggingface dataset:
erector spinae plane block versus oblique subcostal transverses abdominis plane block

Conditions: Postoperative Pain

Summary: comparing the impact of bilateral erector spinae plane block and transverse abdominis plane block on improving quality of pain management after umbilical hernia repair.

postoperative pain is an important problem after umbilical hernia repair which has negative effects on patient's hemodynamics and cause delayed ambulation resulting in prolonged duration of hospital stay and poor patient satisfaction. multiple analgesic strategies have been proposed including non steroidal anti-inflammatory drugs (nsaids), opioids, epidural analgesia. each of them has its limitations. ultra¬sound guided regional anesthesia techniques for abdominal wall can be effective components of multimodal postoperative analgesia with limited side-effects erector spinae plane (esp) block is a promising para-spinal bock that can achieve both visceral and somatic abdominal analgesia if the injection was performed at a lower thoracic level. transverse abdominis plane (tap) block which is considered a peripheral nerve block that is aimed at anesthetizing nerves supplying the anterior abdominal wall. we will compare between erector spinae plane block and transverse abdominis plane block for controlling postoperative pain after umbilical hernia repair. patients will be allocated randomly into two equal groups by a computer-generated randomization table group (e) (n=26): patients will receive erector spinae plane (esp) block after completion of surgery. group (t) (n= 26): patients will receive oblique subcostal transverse abdominis plane (tap) block after completion of surgery

Eligibility criteria:
inclusion criteria: * patients scheduled for elective umbilical hernia repair. * patient acceptance. * both sex * patient's age 21 - 60 years. * patients with american society of anesthesiologists (asa) physical status i, ii. * bmi 25 - 30 kg m-2. exclusion criteria: * uncooperative patients and patients with psychological problems. * patients with liver or renal impairment. * patients with contraindication to regional anesthesia. * patients with history of allergy to drug used in the study. * patients with chronic pain.
music of choice to decrease anxiety during radiation treatment

Conditions: Anxiety; Cancer

Summary: the primary hypothesis of the study is that listening to music will reduce anxiety in female cancer patients during the first radiotherapy treatment session.

receiving radiotherapy induces anxiety in at least 1/3 of patients who did not have a previously existing anxiety condition1. female gender is a positive predictive factor for psychosocial decline during radiotherapy. one-fourth of patients disrupt their planned radiotherapy treatment course due to anxiety. music therapy has demonstrated effectiveness in reducing anxiety when implemented in other medical settings including mechanical ventilation, burn debridement and venipuncture in pediatric patients. there have been some trials which have found a reduction in anxiety when pre-recorded music along with other relaxation techniques have been implemented during radiotherapy. this trial seeks to investigate the benefit of pre-recorded music alone in reducing anxiety experienced during the first radiotherapy treatment session in female cancer patients.

Eligibility criteria:
inclusion criteria: * scheduled to receive radiotherapy for malignant tumor * ecog performance status 0-4 * fluent in english language * inclusion in this study will not be based on race or ethnicity * patients must be deemed able to comply with the treatment plan. * patients must provide study specific informed consent prior to study entry. exclusion criteria: * prior history of radiation therapy

Keywords: music therapy first radiotherapy anxiety reduction psychosocial functioning state - trait anxiety inventory (stai) symptom distress thermometer (sdt)
bacterial colonization after tunneling in femoral perineural catheters

Conditions: Bacterial Colonization

Summary: background: bacterial colonization of peripheral nerve catheters is frequent, although infection is relatively rare. with central venous catheters, the tunneling of catheter into the subcutaneous tissue significantly decreases catheter colonization and catheter-related sepsis. purpose: the aim of this study is to evaluate the incidence of bacterial colonization in adult patients with femoral tunnelized perineural nerve catheters. methods: a total of 338 patients with femoral catheter will be included in the study. the patients will be randomized to be included in the control group (without tunnelling) or in the group with catheter tunneled 2-3 cm subcutaneously. after removal, catheter will be analyzed for colonization (primary outcome). quantitative culture will be used as described by brun-buisson for intravascular catheters. the site of insertion will be monitored daily for any signs of infection (secondary outcome). perspective: to show the incidence of femoral perineural catheter colonization is low with subcutaneous tunneling


Eligibility criteria:
inclusion criteria: * patients scheduled to undergo scheduled orthopaedic surgery performed with a femoral perineural catheter exclusion criteria: * age under 18 years * local nerve pathology * refusal to regional anaesthesia * major psychological disorder * major cardiac conduction disease * infection at the puncture site

Keywords: femoral perineural catheter tunnelization complication colonization infection
resistance training effects on gut microbiome and cardiometabolic outcomes

Conditions: Exercise Intervention

Summary: the overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.

the overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.

Eligibility criteria:
inclusion criteria: * age 18-35 years * bmi: 25-45 kg/m2 * sedentary lifestyle * consistent diet patterns * weight-stable (\<4 kg change over the last 3 mo) * willingness to adhere to resistance training protocol and not change diet * non-smoker \>1 year or more exclusion criteria: * disabilities preventing adherence to resistance training protocol * recent start of medications that affect metabolism or appetite * antibiotics * diabetes * drug therapy for coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia * uncontrolled hypertension and blood pressure ≥ 180/110 * gastrointestinal disease and/or bariatric surgery * smoking * illicit drug use * pregnant or lactating individuals

Keywords: gut microbiome resistance training physical activity
role of apfel's score in predicting postoperative nausea and vomiting after laparoscopic cholecystectomy

Conditions: APFEL RİSK SCORE; Post Operative Nausea and Vomiting (PONV)

Summary: the goal of this observational study is to assess the role of apfel's score in predicting postoperative nausea and vomiting (ponv) after laparoscopic cholecystectomy in patients with symptomatic cholelithiasis. the main questions it aims to answer are: 1. does apfel's score accurately predict the occurrence of ponv after laparoscopic cholecystectomy? 2. which components of apfel's score are most strongly associated with ponv? participants will undergo laparoscopic cholecystectomy under general anesthesia. researchers will calculate each participant's apfel score preoperatively, and postoperative outcomes, such as nausea and vomiting, will be monitored for 24 to 48 hours. researchers will compare ponv incidence among patients with varying apfel scores to determine if higher scores correlate with a higher risk of ponv.


Eligibility criteria:
inclusion criteria: * patients aged 18 to 90 years. * patient scheduled for elective laparoscopic cholecystectomy for symptomatic cholelithiasis. * patients who provided written informed consent to participate in the study. exclusion criteria: * patients receiving prophylactic antiemetic medications prior to surgery. * patients on opioid analgesics for reasons other than the surgical procedure. * pregnant women. * patients whose laparoscopic cholecystectomy was converted to open cholecystectomy during the operation.
the effect of probiotics (l. helveticus, b. longum, and b. bifidum) on immune function and digestive health

Conditions: Healthy

Summary: the purpose of this study is to determine if daily consumption of a probiotic in the period before, during and after academic exams will help maintain digestive and immune health and quality of life of undergraduate students.

a randomized, double-blinded, placebo-controlled trial will be used. healthy full-time undergraduate students will be recruited from the university of florida via flyers, emails, announcements, etc. informed consent will be obtained and the inclusion/exclusion criteria will be reviewed to determine whether a participant qualifies for the study. all participants will be consented for the main six-week intervention and a subgroup (n=50/group) of these students will be consented to provide two stool samples. participants will provide saliva and stool samples (for the sub-group)during the pre-baseline week and during the week of final exams at approximately week 4. at the randomization visit, height, weight and age will be obtained. participants will be stratified based on body mass index and randomized via sealed envelopes to one of four groups: lactobacillus helveticus, bifidobacterium longum ssp. infantis, bifidobacterium bifidum or the placebo (n=145/group). participants will take the study provided capsule of probiotic or placebo daily for 6 weeks. participants will receive daily questionnaires via email throughout the prebaseline week and the 6-week intervention. daily questionnaires will ask about intake of the supplement, cold symptoms, and general health (i.e., new medications, doctor visits). throughout the study, participants will also be asked to complete weekly questionnaires (inquiring about gastrointestinal symptoms and physical activity) and quality of life questionnaires (administered during pre-baseline, final exam week and week 6 of the study).

Eligibility criteria:
inclusion criteria: to participate in the study you must: * be 18 years of age or older. * be a healthy full-time undergraduate at the university of florida. * be willing to complete daily questionnaires form via computer. * be willing to discontinue any immune-enhancing dietary supplements (e.g., prebiotics and fiber supplements, probiotics, echinacea, fish oil, vitamin e \>400% of the rda or \>60 mg/day). * be willing to take the probiotic capsule daily of 6 weeks. * have had at least one cold in the last 12 months. * have at least 1 final during the scheduled exam week. * have daily access to the internet. exclusion criteria: to participate in the study you must not: * be a current smoker. * have chronic allergies involving the upper respiratory tract. * have had immunosuppressive illness or treatment within the last year. * have received antibiotic therapy in the past two months.

Keywords: probiotics cold flu immune function microbiota
preliminary validation of an in vitro diagnosis-medical device for hepatitis b screening

Conditions: Hepatitis B; Healthy; Diagnoses Disease

Summary: the principal objective of the study is to perform a first step of technical adjustment and preliminary validation of a diagnostic test for hepatitis b (hbsantigen, anti-hbs antibody and anti-hbc antibody) on capillary blood with the device under study in non-immunized subjects against hepatitis b, in subjects with hepatitis b, in subjects with old or cured hepatitis b and in hepatitis b vaccine recipients, compared with the values obtained with the reference technique of medical biology laboratory on serum. the analysis will be performed on the entire cohort.

the diagnosis of hepatitis b in precarious populations is often difficult. the use of a in vitro diagnosis-medical device in point of care could alleviate this difficulty. it would identify whether or not the subjects are infected with the virus, whether they are immunized or not. then, depending on the results, the subjects could be directly vaccinated or referred to a laboratory of medical biology for confirmation / invalidation of the diagnosis.

Eligibility criteria:
inclusion criteria: * group 1: hbsag negative, anti hbc negative, anti hbs negative, during a laboratory assay on serum * group 2: hbsag negative, anti hbc negative, anti hbs positive, during a laboratory assay on serum * group 3: hbsag negative, anti hbc positive, ab anti hbs positive or negative, during a laboratory assay on serum * group 4: hbsag positive, anti hbc positive, anti hbs negative, during a laboratory assay on serum * all: affiliated to social security or beneficiary of such a scheme exclusion criteria: * infection by a confounding factor: hiv, hcv and / or hdv * protected person: pregnant woman, parturient, mother who is breastfeeding, person deprived of liberty by judicial or administrative decision, person subject to a legal protection measure * exclusion period for other research studies involving the human person * annual threshold of allowances for participation in research involving the affected human person.
blood viscosity in polycythemia patients

Conditions: Polycythemia Secondary; Polycythemia, Primary

Summary: polycythemia (pg) corresponds to an increase in erythrocyte parameters on a blood test. a distinction is usually made between primary and secondary pg. the most common primary pg is vaquez's disease, a hematological cancer. in vaquez disease, an increase in hematocrit has been reported to be associated with a logarithmic increase in blood viscosity. the main complications of primary pgs (especially in vaquez disease) are thromboembolic complications. in contrast, thromboembolic complications are rarer in secondary pg. in vaquez disease, a hematocrit ≤ 45% has been defined as the therapeutic goal for significantly reducing thromboembolic risk. however, this has not been established for secondary pgs. all in all, the definition of the 45% threshold is based solely on clinical studies with no obvious biological argument. what's more, simply lowering blood mass through cytoreduction alone does not appear to be sufficient to significantly reduce thromboembolic risk. to investigator knowledge, there are no studies prospectively evaluating blood viscosity, its determinants and coagulation in different types of polycythemia. nor are there any data on the direct effect on blood viscosity of the various treatments usually offered.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * followed for a diagnosis or suspicion of polycythemia (hematocrit greater than or equal to 49% in men and 48% in women), whatever the suspected etiology. * patient affiliated to a social security scheme or similar exclusion criteria: * patient having undergone therapeutic bloodletting within 3 months prior to inclusion, or having initiated cytoreductive therapy prior to inclusion. * any disease or condition other than polycythemia, chronic or not, likely to induce a change in blood viscosity (at the investigator's discretion) * patient participating in another interventional research protocol that may interfere with the present protocol (at the investigator's discretion). * patient under guardianship, curatorship or safeguard of justice * person under psychiatric care * patient under legal protection.

Keywords: polycythemia viscosity thromboelastometry thrombosis
osteopathy and children with congenital heart disease surgery

Conditions: Congenital Heart Disease

Summary: osteopathic care impact on postoperative pain assessed by osteopathic session, evaluated by evendol scale surgery on children with congenital heart disease

the management of pain in children after cardiac surgery is the key to ensure a better comfort and fast home return. aside drugs and psychology or physical therapy, no other alternative is proposed in the medico-surgical unit of pediatric cardiology at the necker hospital. following a feasibility study within the department, osteopathic care showed significant pain reduction in postoperative surgery assessed through the evendol scale. the goal was mainly to improve mobility restricted areas due to the operation, and so help to reduce post-operative pain. investigators propose to continue the assessment of the overall osteopathic taking care of the child after heart surgery while retaining evendol scale as primary endpoint. population will include children from the age of 5 days to less than 7 years old.

Eligibility criteria:
inclusion criteria: * children aged 5 days to 7 years old * congenital heart sternotomy or thoracotomy operated * postoperative management at the necker hospital in paris, followed by professor damien bonnet team * agreeing to participate of one of the holders of parental authority * oral agreement child age * minimal knowledge of french language by parents * covered by the french social security system exclusion criteria: * heart disease treated by interventional catheterization * postoperative complications requiring more than three weeks of intensive care * participation in an other biomedical research protocol * refusal or linguistic or mental disabilities or parents of the child
cohort study to identify cancer patients at high risk of venous thromboembolism

Conditions: Cancer; Deep Venous Thrombosis; Pulmonary Embolism

Summary: cancer patients are at increased risk of deep venous thrombosis and pulmonary embolism, collectively termed venous thromboembolism (vte). risk assessment scores for vte in cancer patients have been previously developed by the groups of khorana and vienna cats. however, routine thromboprophylaxis for ambulatory cancer patients based on these scores is currently not recommended. in the investigators prospective, observational cohort study, the investigators aim to identify cancer patients at high risk for vte based on clinical characteristics, coagulation biomarkers and the coagulant activity of tissue factor bearing microparticles.


Eligibility criteria:
inclusion criteria: * stage iii or iv esophageal carcinoma, gastric carcinoma, intestinal carcinoma, pancreatic carcinoma, ovarian cancer, breast carcinoma, prostate cancer, urothelial cell carcinoma or lung carcinoma (small cell or non-small cell) who have started chemotherapy no more than 3 months ago * chemotherapy started no more than 3 months ago or within 7 days after enrollment * aged 18 years or older * written informed consent exclusion criteria: * use of anticoagulants (heparin, vitamin k antagonists or direct oral anticoagulants) * adjuvant chemotherapy (i.e. after surgery with curative intent)
continuation with vortioxetine in child and adolescent patients with major depressive disorder (mdd) from 7 to 17 years of age

Conditions: Depressive Disorder, Major

Summary: evaluation of the long-term safety and tolerability of vortioxetine in child and adolescent patients with a diagnostic and statistical manual of mental disorders, 5th edition (dsm-5™) diagnosis of mdd


Eligibility criteria:
inclusion criteria: * the patient is a male or female child aged ≥7 and \<12 years or an adolescent aged ≥12 and ≤17 years at baseline in study 12712b. * the patient must have completed extension study 12712a immediately prior to enrolment into this extension study. * the patient had a primary diagnosis of a mdd at entry in study 12709a or 12710a, diagnosed according to dsm-5™. * the patient is still indicated for long-term treatment with vortioxetine according to the clinical opinion of the investigator. exclusion criteria: * the patient has been diagnosed with another psychiatric disorder (for example mania, bipolar disorder, schizophrenia or any psychotic disorder) during study 12712a. * the patient has an attention-deficit/hyperactivity disorder (adhd) that requires a pharmacological treatment other than a stimulant medication. other protocol-defined inclusion and exclusion criteria may apply

Keywords: children adolescent
face masks to reduce sars-cov-2 infections (covid-19) in bangladesh

Conditions: Covid19

Summary: the primary goal of the village-level intervention is to assess whether mask-wearing reduces community-level asymptomatic and symptomatic sars-cov-2 infections, assessed via pcr testing. the study also examines if community-based activation through values or individual activation through information results in higher mask-wearing.

detailed description: this study intends to answer the following research questions: can mask distribution and mask promotion at homes, mosques, markets and other public areas successfully change community mask-wearing norms to increase mask-wearing, even years into a pandemic? can community mask-wearing reduce sars-cov-2 infections (both symptomatic and asymptomatic)? is increased prevalence of community-level mask-wearing associated with decreased physical distancing? to answer these questions, the investigators will conduct a cluster randomized trial which randomizes the proposed intervention at the village level in bangladesh. control communities will receive no intervention and treatment communities will receive an extensive intervention combining several elements. study staff will distribute free face masks through door-to-door visits and at markets and mosques. in some communities groups of people will be encouraged to wear masks by appealing to their shared values and in other communities individuals will be encouraged to wear masks by discussing the biological value of masks (cross-randomized among intervention communities). mask promoters in the community and at markets in treated villages will remind people about the importance of wearing masks and distribute additional masks. markets will have signs that masks need to be worn to enter the market. religious leaders will encourage mask use at religious services. the project will enroll 1200 communities, stratified in geographically proximate groups of 10; half will be randomized to receive the intervention. communities will be surveilled through direct observation at 0, 2, and 4 weeks to assess mask-wearing. the investigators will assess symptomatic and asymptomatic sars-cov-2 by conducting household visits every 6-10 days to ask about symptoms of covid-19 and collecting nasal swabs to test by pcr for the presence of sars-cov-2. end line is planned for 4 weeks after the intervention begins, but may be shifted according to seroprevalence trends.

Eligibility criteria:
inclusion criteria: * live in selected village exclusion criteria: * none

Keywords: masks transmission bangladesh behavioral psychology