Kornimate/medical-research-clean huggingface dataset:
optimization of health expenditure in liver surgery

Conditions: Hepatocellular Carcinoma; Hilar Cholangiocarcinoma; Intra Hepatic Cholangiocarcinoma; Liver Metastasis

Summary: the aim of this study is to reduce the length of stay after liver surgery by taking account of objective quantitative clinical variables, subjective qualitative clinical variables and non clinical variables.

a new dimension of the activity expected of physicians is to improve the safety of care on the one hand and the control of health care costs on the other. key measures to help them are the publication of national recommendations, assessment of actual practices and the incentive to activity. internationalwide recent and concordant data suggest that * quality and security of care, after an initial improvement, are going to stall * scientific recommendations are rarely validated by an impact analysis and are not applied * clinical data collected within an administrative framework are unreliable and too generalist * the evaluation, especially in the surgical field, is based on indicators sometimes irrelevant and often unclear

Eligibility criteria:
inclusion criteria: * elective liver surgery * older than 18 * agreed to participate * surgical procedure included procedures registered as "hlfa003 - 007 ; 009 - 011 ; 017 - 020 ; hlfc002 à 004 ; 027 ; 032 ; 037" in the pmsi database exclusion criteria: * emergency surgery * refused to participate

Keywords: liver tumor carcinoma cholangiocarcinoma metastasis
image-guided biopsies to identify mechanisms of resistance in patients with metastatic castration resistant prostate cancer treated with 177lu-psma radioligand therapy

Conditions: Castration-Resistant Prostate Carcinoma; Metastatic Prostate Carcinoma; Stage IV Prostate Cancer American Joint Committee on Cancer (AJCC) v8; Stage IVA Prostate Cancer AJCC v8; Stage IVB Prostate Cancer AJCC v8

Summary: this clinical trial studies mechanisms of resistance to 177-lutetium prostate specific membrane antigen (177lu-psma) radioligand therapy using image-guided biopsies in patients with castrate-resistant prostate cancer that had spread to other places in the body (metastatic). diagnostic procedures, such as image guided biopsies, may help in learning how well 177lu-psma works to kill tumor cells and allow doctors to plan better treatment.

primary objective: i. proportion of metastatic castration resistant prostate cancer (mcrpc) patients with molecular and cellular alterations in tumor, immune and stromal cells after radioligand therapy assessed by histopathology/immunohistochemistry, ribonucleic acid (rna)-sequencing and proteomic/phospho-proteomic analyses of biopsy samples. secondary objective: i. sequencing to identify frequently mutated genes. outline: patients undergo an image-guided biopsy at baseline and 2-4 weeks after cycle 2 of 177lu-psma-617 therapy.

Eligibility criteria:
inclusion criteria: * volunteer patient * histologically confirmed prostate cancer * eligible for 177lu-psma-617 under expanded access protocol (irb# 21-5010) or as part of an approved trial * based on positron emission tomography (pet)/computed tomography (ct) images: evidence of lymph node or soft tissue metastatic disease amenable to image-guided biopsy * platelets \> 75,000/ul within 14 days prior to biopsy * prothrombin time (pt) or international normalized ratio (inr) and a partial thromboplastin time (ptt) \< 1.5 times the institutional upper limit normal (uln) within 14 days prior to biopsy * patients on warfarin, aspirin, or other anti-coagulants are eligible provided they are deemed able to tolerate discontinuation of anti-coagulation for one week prior to the biopsy. conversion to low molecular weight heparin prior to biopsy is permitted per local standard operating procedures, provided there is agreement regarding the procedure between the treating physician, the interventional radiologist and the principal investigator (pi) exclusion criteria: * patients with significant congenital or acquired bleeding disorders (e.g. von wildebrand's disease, acquired bleeding factor inhibitors) are not eligible
effect of use of a new technique for pediatric urine collection in er

Conditions: Urinary Tract Infection; Unspecified Fever

Summary: urinary tract infection is most common serious bacterial infection in children who admit into the emergency department (ed). however the collection of urine from young children is time consuming process. so many children and their family guardian waste time until medical disposition established. in 2013, maria luisa herreros fernandez etc have suggested a new urine collection technique for newborn, that bladder and lumbar stimulation technique is fast and safe. the aim of this study is to determine clinical efficacy of bladder and lumbar stimulation technique (blst) for pediatric patient in ed.

bladder and lumbar stimulation technic step 1 - oral or iv hydration : aprropriate to the weight of the children step 2 - bladder stimulation : gentle tapping in the suprapubic area at a frequency of 100 taps per minute for 30 sec step 3 - lumbar stimulation : lumbar paravertebral zone in the lower back with a light circular massage for 30 sec both stimulation manoeuvres are repeated until micturition starts and a midstream urine sample can be caught in a sterile collector

Eligibility criteria:
inclusion criteria: * children have unspecific fever and requiring and urine test exclusion criteria: * initial shock state * history of congenial urinary tract abnormality * parents who have declined taking part in the research
effects of local treatment with and without sensorimotor and balance exercises in neck pain

Conditions: Neck Pain

Summary: the sensorimotor disturbance and postural instability have been demonstrated to be associated with neck pain. specific therapeutic exercise and manual therapy for the cervical spine are effective interventions for improving dizziness symptoms, neck impairments, functional ability and quality of life. however, the effects of these interventions on the actual impairment of joint position sense and balance remain uncertain. adaptive changes in the sensorimotor and postural control systems may need to be specifically addressed.

the sensorimotor (joint position sense and oculomotor control) and postural stability (balance) disturbances have been demonstrated to be associated with neck pain. specific therapeutic exercise directed to neuromuscular impairments and manual therapy for the cervical spine are effective interventions for improving dizziness symptoms, neck impairments, functional ability and quality of life. however, the effects of these interventions on the actual impairment of joint position sense and balance remain uncertain. adaptive changes in the sensorimotor and postural control systems may need to be specifically addressed. currently, it is not known whether the clinician has to train every impairment or can choose between sensorimotor training and balance training in the rehabilitation of neck pain. different training approaches may have specific influences on the different outcomes and their outcomes will be important to inform the optimal and efficient management of persons with chronic neck pain.

Eligibility criteria:
inclusion criteria: * insidious neck pain for at least 3 months * an average neck pain intensity over the past week ≥ 30 mm on a 100 mm visual analog scale (vas) * a score of neck pain and disability ≥ 10/ 100 on the neck disability index-thai version * an absolute error of cervical joint position error \> 4.5° * an inability to stand in tandem stance with eyes closed for 30 seconds * cervical segmental joint dysfunction (pain provoked \>2/10 with abnormal tissue resistance) exclusion criteria: * a previous history of neck and head injury or surgery * known or suspected vestibular pathology * vertigo or dizziness caused by underlying pathology in the ear, brain, or sensory nerve pathways (e.g. benign paroxysmal positional vertigo and bppv) * vascular disorders (e.g. a migraine and hypertension) * any musculoskeletal or neurological conditions that could affect a balance * inflammatory joint disease * systemic conditions * cognitive impairment * taking four or more medications * received physiotherapy treatment for their neck disorder in the past 12 months

Keywords: manual therapy sensorimotor exercises balance exercises cervical mobilization specific neck muscle exercises
patient-derived xenografts to reduce cancer health disparities

Conditions: Bladder Carcinoma; Gastric Carcinoma; Liver and Intrahepatic Bile Duct Carcinoma; Lung Carcinoma; Malignant Neoplasm

Summary: this trial establishes patient-derived cancer xenografts in addressing cancer health and treatment disparities that disproportionately affect racial/ethnic minorities. understanding the genetic and response differences among racial/ethnic minorities may help researchers enhance the precision of therapeutic treatments.

primary objectives: i. develop and characterize over 200 patient-derived xenografts (pdxs), with at least 50 pdxs each for gastric, liver, bladder, and lung cancers with 60% (approximately) of the pdxs from minority patients, focusing on hispanic/latino americans \[hlas\], african americans \[aas\], and asian american/native hawaiians/pacific islanders \[aanhpis\]. ii. utilize these pdxs in preclinical testing of single agents and drug combinations to guide precision cancer medicine decision-making with a focus upon the predominant racial/ethnic minority populations residing in california compared to non-hispanic whites \[nhws\]. iii. conduct "characterizing treatment responses with pdx models for gastric and liver tumors" as research project 1, focused on the most common histological forms of gastric cancer (gc) and liver cancers (lc) primarily from hlas and aanhpi patients. iv. conduct "characterizing treatment responses with pdx models for lung and bladder tumors" as research project 2, focused on lung squamous cell carcinoma (lscc) and advanced urothelial or bladder cancer (abc) primarily from aa and nhw patients. v. collaborate with the national cancer institute (nci), other pdx development and trial centers (pdtcs), non-pdxnet, pdxnet data commons and coordinating centers to fulfill the mission of the pdxnet. vi. select and conduct pilot projects through the pilot projects and trans-network activities core (pptnac) inclusive of ucamp members, other pdtcs and beyond that will evaluate comparative therapeutic responses using pdx models and contribute to the elucidation of biological determinants of cancer health disparities in gastric, liver, bladder, and lung cancers. outline: patients undergo collection of tumor tissue samples during standard of care tumor biopsy or surgical resection to establish pdxs. patients may also undergo collection of blood, saliva, and urine samples to compare deoxyribonucleic acid (dna) abnormalities to noncancer cells in order to determine if they were present before the cancer started or developed with it.

Eligibility criteria:
inclusion criteria: * patient receiving treatment for the above 4 cancers (bladder cancer, lung cancer, gastric/stomach cancer, and liver cancer) * signed informed consent that will be put on file exclusion criteria: * no informed consent obtained * specimen unacceptable/degraded/etc. * individuals who are not yet adults (infants, children, teenagers) * pregnant women * prisoners * adults unable to consent
effect of exercises in patients with stroke

Conditions: Stroke; Exercise

Summary: aim: this study was conducted as a randomized controlled experimental study to determine the effect of rom exercises applied to individuals who had a stroke on functional independence and quality of life. design: this study was conducted as a randomized controlled experimental study methods: the study was conducted with 80 individuals, 40 of whom were in the intervention group and 40 in the control group, who received inpatient treatment in the neurology service of a regional city hospital, and met the inclusion criteria. planned rom exercises were applied to the individuals in the intervention group 3 times a day for 2 weeks, and no application was made to the control group other than routine treatment. data were collected by the researcher using the questionnaire form, patient information form, functional independence scale and stroke specific quality of life scale.


Eligibility criteria:
inclusion criteria: * being over 18 years old, * coming to the hospital within 72 hours of having a stroke, * a definitive diagnosis of cerebrovascular diseases according to the diagnostic criteria, * having a hemiplegic condition, * having a score of 13 or higher on the glasgow coma scale, * not to be involved in any special exercise program other than the service routine, * having approval from the clinician about there is no harm in doing rom exercises, * agreeing to participate in the study exclusion criteria: * people with quadriplegia/tetraplegia, * those with psychiatric illnesses, * those who have any extremity amputated, * those who have open wounds that prevent exercise and cause bleeding, * those with fractures in their body and those who had an orthopedic operation

Keywords: functional independence stroke rom exercises quality of life
oral contraceptive ethinyl estradiol dose effect on postpartum depression and sexual functioning scales

Conditions: Postpartum Depressive Mood; Postpartum Sexual Function

Summary: this is a prospective, randomized, controlled cohort study. this study will look at the effect of ethinyl estradiol 35mcg/norethindrone 1mg and ethinyl estradiol 20 mcg/norethindrone 1mg on postpartum depressive symptoms and sexual function scores when compared to a control group using no hormonal contraception. depressive symptoms and sexual function will be measured using the edinburgh postnatal depression scale (epds), arizona sexual experiences scale (asex), and brief index of sexual functioning for women (bisf-w). participants will begin taking the medication at week 3 postpartum, and these outcomes will be measured at baseline (0-1 day postpartum), week 3, and week 6-7. the investigators hypothesize that there will be an ethinyl estradiol dose related response in epds, asex, and bisf-w scores at week 6-7, which would indicate a decrease in depressive symptoms and increase in sexual function in both of the oral contraceptive groups.


Eligibility criteria:
inclusion criteria: * 18-45 year old women who desire contraception postpartum for at least 6 weeks. * 18-45 year old women who choose not to use oral contraceptive medication postpartum for at least 6 weeks for the control group. exclusion criteria (medication groups): * breastfeeding (although this may limit participant enrollment, combined oral contraceptives are contraindicated in this population). * delivery by cesarean section. * previous history of depression, mood disorders, or psychiatric disorders. * any condition (history or presence of) which contraindicates the use of combination ocs, including: * thrombophlebitis or thromboembolic disorders, known or suspected clotting disorders, deep vein thrombosis, thrombogenic valvulopathies or rhythm disorders. * pulmonary embolism. * cerebrovascular or coronary artery disease or myocardial infarction. * diabetes mellitus. * migraine headaches with focal, neurological symptoms. * chronic renal disease. * uncontrolled or untreated hypertension. * cholestatic jaundice. * known or suspected carcinoma of the breast, endometrial carcinoma, or known or suspected estrogen-dependent neoplasia. * impaired liver function or disease, hepatic adenomas or carcinomas. * known hypersensitivity to estrogens and/or progestins. * history of thyroid disorders. * recent alcohol or drug use. * smoking and age ≥35 or smokers who will become 35 years of age during the study. * known history of noncompliance with taking medication. exclusion criteria (control group): * previous history of depression, mood disorders, or psychiatric disorders. * recent alcohol or drug use.
the effects of micronutrients in combination with usual care in type 2 diabetes

Conditions: Type 2 Diabetes

Summary: this study is evaluating the impact of antioxidant supplements on blood sugar control and cardiovascular risk factors in adults over the age of 50 with at 3 months of type 2 diabetes. the investigators hypothesize that daily supplementation with a multiple micronutrient formulation containing dietary and endogenous antioxidants in combination with usual care will reduce markers of oxidative stress and inflammation in type 2 diabetes.

this study is evaluating the impact of an antioxidant and micronutrient supplement on markers of oxidative stress and inflammation as well as on blood sugar control in adults over the age of 50 who have had type 2 diabetes for at least 3 months. the purpose of this study is to see if these antioxidants reduce the oxidative and inflammatory state seen in patients with type 2 diabetes as well as whether or not they make it easier to control blood sugar, affect the number and dosage of diabetic medications, and/or reduce the risk factors involved in long-term diabetes related complications such as in lipid profile and carotid intima-media thickness (cimt).

Eligibility criteria:
inclusion criteria: 1. patients with a diagnosis of type 2 diabetes of at least three months duration 2. 50 years of age or older 3. stable medical status (e.g., no myocardial infarction, stroke, major surgery, or major mental illness during the previous six months) 4. not taking or not expected to be taking any oral glucocorticoids (except for replacement therapy for those with adrenal insufficiency), amphetamines, anabolic, or weight-reducing agents during the course of the study 5. not receiving chemotherapy or immunosuppressive therapy 6. military healthcare beneficiary exclusion criteria: 1. patients with type 1 diabetes or those with type 2 diabetes of less than 3 months duration. 2. inability to communicate in written and spoken english 3. organ (kidney, pancreas, liver) transplant recipients 4. individuals who are not likely to return for the follow-up because they or their sponsors are likely to have a permanent change of station or termination of service before completion of the protocol 5. pregnancy (women who are pre-menopausal will be informed that pregnancy must be ruled out by a serum hcg test if they would like to be considered for participation in the study. women who have had a hysterectomy or have not had a menstrual period for at least one year prior to consent will be considered post-menopausal and will not require a serum pregnancy test). 6. patients who are routinely taking more than 81 mg aspirin (asa)/day or who are using asa or asa-containing products to manage a chronic condition.

Keywords: type 2 diabetes carotid intima medial thickness micronutrient anti-oxidant
study of an anti-ox40 monoclonal antibody (khk4083) in subjects with moderate to severe atopic dermatitis

Conditions: Atopic Dermatitis

Summary: a phase 2, multicenter, randomized, placebo-controlled, double-blind, parallel-group study for subjects with moderate to severe ad whose disease cannot be adequately controlled with topical medications or for whom topical treatment is medically inadvisable.


Eligibility criteria:
inclusion criteria: * voluntarily signed informed consent to participate in the study; * chronic ad, according to american academy of dermatology consensus criteria or the local diagnostic criteria, that has been present for at least 1 year before screening; * easi score ≥16 at screening and baseline; * iga score ≥3 (moderate) at both screening and baseline; * bsa ≥10% at both screening and baseline; * documented recent history (within 1 year prior to screening visit) of inadequate response to treatment with topical medications or for whom topical treatments are otherwise medically inadvisable (e.g., because of important side effects or safety risks). exclusion criteria: * current or past history of clinically significant illness(es) deemed by the investigator to be likely to affect the study conduct and assessments. examples include, but are not limited to, clinically significant cardiovascular (e.g., new york heart association \[nyha\] class iii or iv), uncontrolled diabetes (hba1c ≥9%), liver (e.g., child-pugh class b or c), renal, respiratory, hematologic, central nervous system, psychiatric, or autoimmune diseases/disorders; * any of the following laboratory abnormalities at screening: * serum creatinine: \>1.5 mg/dl * ast or alt: ≥2.5 times the upper limit of normal (uln) * neutrophil count: \<1.5×10³/μl * other laboratory abnormalities that may affect the completion or evaluation of the study, as judged by the investigator; * active malignancies, or onset or a history of treatment of malignancies within 5 years prior to informed consent (except curatively treated in situ cervical carcinoma, cutaneous basal cell carcinoma, or cutaneous squamous cell carcinoma).

Keywords: ad eczema skin diseases biologics
rectal washout in transanal total mesorectal excision and presence of intraluminal malignant cells

Conditions: Rectal Cancer

Summary: the study aims to assess the existence of intraluminal malignant cells and the appropriate fluid volume needed to perform rectal washout during transanal total mesorectal excision (tatme) for rectal cancer.

twenty patients undergoing tatme for rectal cancer is included. following the closure of the rectal lumen by a purse string suture, rectal washout is performed with a total of 500 ml sterile water. fluid samples are collected after every 100 ml by instilling 50 ml of saline after each washout. a sixth sample is collected from the presacral cavity. each sample is cytologically examined by a pathologist and labelled either malignant or non-malignant.

Eligibility criteria:
inclusion criteria: * surgery at slagelse hospital for rectal cancer with transanal mesorectal excision * consent to participate in the study exclusion criteria: * no consent to participate * no surgery

Keywords: rectal washout transanal total mesorectal excision rectal cancer
tcm for post-operative edema

Conditions: Anterior Cruciate Ligament Injuries

Summary: there are loads of research on knee surgery, including surgical methods, rehabilitation strategies, and complication prevention. whether it is general surgery or endoscopic surgery, there may be postoperative joint swelling, which may last for several weeks depending on the patient's condition. therefore, reducing swelling as soon as possible is important in post-operative treatment. swelling of the knee joint may increase soft tissue tension, causing pain and discomfort, and affecting the range of motion and functional recovery of the joint. it may also affect wound healing and increase the risk of complications such as infection and thrombosis. most clinical research related to traditional chinese medicine focuses on reducing pain, and little attention is paid to reducing swelling, relatively. nevertheless most relevant literatures discuss total knee replacement surgery. cruciate ligament surgery is very common in sports medicine orthopedics. it is expected that ordinary patients get function recovery quickly after surgery, and athletes can return to play as soon as possible. this study is a prospective study, with partially double-blinded, randomized controlled study design. the investigators are aiming to tcm intervention for knee swelling after cruciate ligament surgery, and evaluation of postoperative swelling and functional improvement. tcm intervention methods are laser acupuncture and external application of herbal medicine.


Eligibility criteria:
inclusion criteria: 1. willing to sign informed consent 2. age between 18-50 years old male and female patients 3. first time receiving cruciate ligament reconstruction 4. willing to accept tcm intervention and follow up exclusion criteria: 1. repeat surgical intervention 2. history of serious acupuncture syncope 3. history of severe allergic response of herbal packing or drug-induced dermatitis 4. history of other diseases that cause knee joint swelling, such as rheumatoid arthritis, knee joint infection, gouty arthritis, connective tissue disease, tumor, or cardiac/renal failure.