Kornimate/medical-research-clean huggingface dataset:
evaluation of functions of swallowing and voice in ankylosing spondylitis patients

Conditions: Ankylosing Spondylitis; Swallowing Disorder.Other Specified; Voice Alteration

Summary: in this study was to determine whether changes that occurred over time had an impact on the swallowing and voice functions depend of ankylosing spondylitis patients.

this study was carried out at the university of health sciences okmeydani training and research hospital, department of otorhinolaryngology. study was performed on 30 patients and 30 healthy subjects (group 2) who were diagnosed with ankylosing spondylitis using modified new york criterion. the patients were asked to fill the eat-10 and flexible endoscopic swallowing evaluation was performed. voice recordings were taken from the patients to evaluate the voice disturbance and acoustic evaluation was taken with praat program.

Eligibility criteria:
inclusion criteria: * diagnosed with ankylosing spondylitis * person who accept to consent form exclusion criteria: * pulmoner diseases * laryngeal polip or nodules * underwent to larynx or esophageal surgery * central nerve system diseases

Keywords: ankylosing spondylitis, swallowing, voice
comparison of carvedilol and atorvastatin for preventing of contrast-induced nephropathy.

Conditions: Contrast-induced Nephropathy

Summary: this prospective study is intended to evaluate if carvedilol has any potential protective effect over atorvastatin on the development of contrast-induced nephropathy (cin) following cardiac catheterization in patients with moderate to high risk for cin.

this study enrolled 150 patients planned for cc, and randomly assigned for one of the three groups. group (a)include 49 patients who received two atorvastatin dose 80 mg 12 hours before cc and 40 mg just before cc. group (b) include 48 patients who received 12.5 mg carvedilol twice daily for 7 days before cc and continue for 24hrs after the day of cc, group (c) include 47 patients who only hydrated with saline. all included patients were hydrated with saline intravenous 0.9 sodium chloride (nacl) at 0.5-1 mg/kg/hour for 4-6 hours before and 4-6 hours after cardiac catheterization. serum creatinine(scr), blood urea nitrogen (bun) and estimated glomerular filtration rate were evaluated at the baseline and after 48 from cc. serum neutrophil-associated lipocalin (ngal) was evaluated after 4 hours from cc.

Eligibility criteria:
inclusion criteria: * patients aged between 18 and 70 years. * serum creatinine ≤ 1.5 mg/dl. * using a moderate dose of atorvastatin (40 mg or equivalent dose of other statins). * moderate to high-risk for cin. exclusion criteria: * patients suffering from st-segment elevation myocardial infarction (stemi) * patients need for immediate cardiac catheterization * elevated liver enzymes (aspartate aminotransferase (ast) and alanine aminotransferase (alt) three times the upper limit of normal). * active infection. * any contraindication to carvedilol, or atorvastatin. * patients on regular use of vitamins, minerals. * using medication with antioxidant properties e.g., beta-carotene, vitamin e, vitamin c, selenium, theophylline or n-acetyl cysteine 7 days prior to cc. * hemodynamically unstable patients (defined as abnormal or unstable blood pressure, especially hypotension (blood pressure less than 90/60 mm hg). * patients who required dialysis. * pregnancy. * using of carvedilol in the past three months. * using a nephrotoxic agent in the past 48 hours or exposure to a contrast agent in the past 7 days prior to cardiac catheterization.

Keywords: cardiac catheterization, carvedilol, atorvastatin.
a prospective non-interventional study protocol with primary data collection - assessment of the long term treatment outcomes of genotropin treatment in growth hormone deficiency (ghd) patients

Conditions: Growth Hormone Deficiency

Summary: the purpose of this study is to assess the long term treatment outcomes of growth hormone treatment in patients who are prescribed and treated with genotropin. also, plan to determine the relationships between clinical status, dosage schedule and response to genotropin treatment. this study will also contribute to our knowledge of adult growth hormone deficiency, including transition period in childhood onset growth hormone deficiency and its treatment.

patients within inclusion criteria are asked to participate in the study.

Eligibility criteria:
inclusion criteria: * adult patients of 18 years of age and above and fulfilling one of the three alternatives a-c below; 1. newly diagnosed with ghd according to the current medical standard. 2. diagnosed with ghd before 2013 and previously treated with genotropin and followed in kims®. 3. transition patients diagnosed with co-ghd before 2013. * prescribed genotropin at the time of inclusion. * evidence of a personally signed and dated informed consent document indicating that the patient (or a legally acceptable representative) has been informed of all pertinent aspects of the study. exclusion criteria: * patients who participate in any concurrent clinical interventional trial where a non-authorized or authorized study medication is used, during their participation in swedish kims® xtended. concurrent studies which do not include any study interventional items (whether medications or devices) are allowed.
myoma microvascularization analysis using sonovue before and after uterine artery embolization

Conditions: Myoma

Summary: contrast-enhanced ultrasound is supposed to improve the detection of myomas as well as improve the follow-up after specific treatments like embolization. it will also help the investigators better understand the mechanism of success or failure for embolization and could reduce the amount of particles injected by determining the endpoint of the procedure in order to treat the myomas while preserving the myometrium.

before embolization of the uterine artery, 40 patients with unique or multiple myomas will be included prospectively in our study and evaluated with sonography before and after injection of sonovue (2.4 ml) (bracco int milano italy). pelvic ultrasound with contrast enhancement will be done the day after and six months after the procedure. microvascularization of the myomas and the endometrium will be described. some tiny myomas which are not visible on conventional sonography could be identified for a perfect matching with mri detection.

Eligibility criteria:
inclusion criteria: * uterine myomas with solid tissue (greater diameter lower than 15 cm) * the embolization is planified during the 15 days after the contrast ultrasonography * written informed consent is signed exclusion criteria: * intracavitary uterine mass possibly due to a polyp or endometrial cancer * necessity of using the endovaginal way of ultrasonography because of the myoma's size and accessibility * menopause * pregnancy and breastfeeding * recent cardiac affection * history of acute cardiac disease

Keywords: embolization contrast enhanced ultrasound myoma uterine artery microvascularisation
screw retained arch bar versus conventional erich's arch bar in maxillomandibular fixation

Conditions: Mandibular Fractures

Summary: a randomized prospective clinical study to compare screw retained arch bar and conventional erich's arch bar in maxillomandibular fixation

2) patients with non-pathological favorable or non-favorable fracture of mandible or maxilla that can be treated by mmf when acceptable occlusion can be obtained via bimanual reduction will be divided randomly into two equal groups: group i: 10 patients will receive conventional erich's arch bar. group ii: 10 patients will receive modified screw retained arch bar.

Eligibility criteria:
inclusion criteria: 1. the patients age ranges from 18 to 50 years. 2. patients with non-pathological favorable or non-favorable fracture of mandible or maxilla that can be treated by mmf when acceptable occlusion can be obtained via bimanual reduction. 3. patients medically free from any systemic disease that absolutely contraindicate the surgical procedures. exclusion criteria: * 1) edentulous ridge fracture. 2) patients having primary and mixed dentition.
basic auditory processing and auditory hallucinations

Conditions: Schizophrenia

Summary: schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population worldwide. although pathophysiology of this disease remains unclear, a growing interest is emerging for low-level sensory function, acknowledging that deficits in early stages of sensory processing are related to higher-order cognitive disturbances in schizophrenia. in the field of auditory processing, symptoms as auditory-hallucinations were found correlated with disabilities to discriminate psychoacoustic parameters of sounds.

outcomes: our main hypothesis is that auditory hallucinations rating scale (ahrs) scores are correlated with the percentage of wrong answers in a tone-matching task test. the main objective is to assess this correlation. our other objectives are to assess correlation between ahrs as well as other symptoms scales and psychoacoustic tests assessing intensity, length discrimination of non-verbal tones and self-monitoring abilities. impact of therapeutic procedures (neuromodulation, psychotherapy) conducted independently of our study on these psychoacoustic tests will also be assessed. methods: 30 subjects with schizophrenia will be included. clinical and psychoacoustic measures will be carried out at j-0. in the case of patients receiving therapeutic procedures independently of our study, new clinical and psychoacoustic measures will be carried out at j+7 and j+30.

Eligibility criteria:
inclusion criteria: * age from 18 to 65 years old * meeting dsm-5.0 criteria for schizophrenia * auditory hallucinations rating scale ≥ 8 * negative βhcg level if woman * effective contraception if woman * consent to be included in the study exclusion criteria: * hearing impairment * neurologic disorder * other psychiatric disorder from the dsm-5.0 section ii * developed musical abilities (regular practice of singing or a musical instrument) * pregnancy * does not consent to be included in the study * lacking in legal capacity

Keywords: pitch discrimination auditory processing disorders auditory perception auditory-verbal hallucinations theory of mind
accuracy of upper lip bite test and measurement of skin-to-epiglottis distance in predicting difficult laryngoscopy: a prospective observational study

Conditions: Difficult Laryngoscopy; Upper Lip Bite Test

Summary: airway management is one of the most important skills in everyday practice of anesthesia. improper airway management might lead to high risk of mortality. clinical parameters alone cannot predict all potentially difficult airways. ultrasonography (us) might play a role as a potential screening tool for difficult airway and given the limited empirical study in this field; this research will focus on using ultrasound to predict difficult airway and difficult mask ventilation for patients undergoing elective operation under general anesthesia. methodology this study is prospective observational . the study will be conducted in cairo university hospital participants are adult patients (above \>40 years), (bmi \ 2 cm can accurately predict difficult laryngoscopy in adult patients undergoing elective procedure under general anesthesia with endotracheal intubation.


Eligibility criteria:
inclusion criteria: * participants will be adult patients (above \>40 years) ( bmi \< 35) with asa-ps i-iii, scheduled for elective surgery under general anesthesia with tracheal intubation. exclusion criteria: * patients with history of difficult intubation or apparent airway abnormalities (facial scars, neck scars, unstable cervical spine and history of cervical spine fixation) that would require alternative technique other than endotracheal intubation. edentulous patients patients undergoing emergency procedure pregnant women were excluded from the study.
cyberknife radiosurgery for organ-confined prostate cancer: homogenous dose distribution

Conditions: Prostate Cancer; Prostatic Cancer; Prostate Neoplasms; Prostatic Neoplasms; Cancer of the Prostate

Summary: the purpose of this study is to determine the effects of cyberknife radiosurgery in patients with early stage organ-confined prostate cancer.

the cyberknife robotic radiosurgery system is a unique radiosurgical system capable of treating tumors anywhere in the body noninvasively and with sub-millimeter accuracy. the cyberknife system delivers radiation using a precise targeting methodology allowing a focal treatment margin around the target, thus limiting the volume of adjacent tissue receiving high doses radiation. this in turn allows the delivery of high doses of radiation to the prostate over a short series of treatments.

Eligibility criteria:
inclusion criteria: * patient must be at least 18 years of age * histologically proven prostate adenocarcinoma * patients belonging in one of the following risk groups: low: clinical stage (cs) t1b-t2a and gleason 2-6 and prostate specific antigen (psa) ≤ 10, or intermediate: cs t2b and gleason 2-6 and psa ≤ 10 or cs t1b-t2b, and gleason 2-6 and psa ≤ 20 ng/ml or gleason 7 and psa ≤ 10 ng/ml * prostate volume: ≤ 100 cc * eastern cooperative oncology group (ecog) performance status 0-1 exclusion criteria: * prior prostatectomy or cryotherapy of the prostate * prior radiotherapy to the prostate or lower pelvis * implanted hardware or other material that would prohibit appropriate treatment planning or treatment delivery, in the investigator's opinion * chemotherapy for a malignancy in the last 5 years * history of an invasive malignancy (other than this prostate cancer, or basal or squamous skin cancers) in the last 5 years. * hormone ablation for two months prior to enrollment, or during treatment.

Keywords: prostate cancer cyberknife stereotactic radiosurgery radiotherapy radiation prostate tumor prostate surgery
goniocurettage as first choice of surgical treatment in chronic open-angle glaucoma: outcomes and complications

Conditions: Open-Angle Glaucoma; Surgery

Summary: the study has the purpose to evaluate the effectiveness and safety of the goniocurettage as a first choice of surgical treatment for primary open-angle glaucoma (poag) in patients with good vision.

a prospective study in 33 eyes (32 patients) with uncontrolled open angle glaucoma under clinical treatment. the trabecular tissue was scraped away from the angle (goniocurettage) in about 100 degrees by means of an instrument similar to a microchalazion curette. the goniocurettage was done under direct visualization of the angle through a gonioscopy lens (swan-jacob) and a surgical microscope. using the 17.0 spss software the investigators compared the intraocular pressure, the numbers of antiglaucomatous medications, the best correct visual acuity, the development of cataract, the central corneal thickness,the impact on the visual field, the impact on the optic nerve head and the central corneal endothelial cell density before and after the goniocurettage, and the intra and post operative complications.

Eligibility criteria:
inclusion criteria: * disc and/or visual field findings consistent with primary open angle glaucoma * uncontrolled intraocular pressure (≥21 mm hg) or progressive glaucomatous neuropathy despite maximum tolerated medical therapy * 40 years old or over * visual acuity higher than 0.2 * open angles (greater or equal to shaffer grade ii) exclusion criteria: * previous ocular surgery * history of glaucoma laser treatment * history of ocular trauma * cyclodestructive procedures * corneal edema or opacities * endothelial decompensation * history of uveitis * secondary glaucoma * neovascularization of the iris or angle * congenital anterior segment abnormalities * anatomically confusing angles without clear definition of the scleral spur or meshwork and inability to maintain follow-up

Keywords: ab-interno trabeculectomy, intraocular pressure, open angle glaucoma trabeculectomy goniocurettage non-filtering surgery
osteopathic manipulative treatment in chronic non-specific neck pain

Conditions: Chronic Pain

Summary: the aim of this study is to investigate the effect of osteopathic manipulative treatment on pain intensity, disability level and psychosocial factors in patients with chronic non-specific neck pain. we hypothesed that osteopathic manipulative treatment is better than conventional physiotherapy in management of pain, disability and depression.

this study will conduct between april 2020 and july 2020 at denizli state hospital. participants who were diagnosed as chronic non-specific neck pain by a specialist physician will include the study. they will treated at physical therapy clinic. inclussion criteria will; participants diagnosed as non-specific neck pain by the physician and non-spesific neck pain at least 3 months. exclussion criteria were; participants who have had surgery or are indicated for surgery, participants who have had exercise therapy and / or physical therapy in the last 1 year with a history of trauma to the cervical region, participants who have had neck pain that develop due to a particular cause such as tumor, compression fracture, metastasis and infection. according to power analysis, 102 participant will include the study with 95% coincidence interval and 80% power. participants will be divided into 2 groups. randomization method will be closed envelope. group 1 will receive conventional physiotherapy programme (cp), group 2 will receive osteopathin manipulative treatment (omt). pain intensity at rest and activity, psychological state( beck depression inventory) and disability level (neck disability index) will assess at baseline and 3 weeks.

Eligibility criteria:
inclusion criteria: * participants diagnosed as non-specific neck pain by the physician. * non-spesific neck pain at least 3 months. exclusion criteria: * participants who have had surgery or are indicated for surgery * participants who have had exercise therapy and / or physical therapy in the last 1 year with a history of trauma to the cervical region * participants who have had neck pains that develop due to a particular cause such as tumor, compression fracture, metastasis and infection

Keywords: osteopathic manipulative treatment chronic non-spesific neck pain conventional therapy
covid19 hospitilized in clinica pasteur of neuquen (argentina)

Conditions: COVID-19

Summary: retrospective cohort (non-experimental study) of covid 19 patients assisted in hospitalization (severe and critical) between 2020 and 2021

consecutive patients with acute infection by sars-cov2 and severe or critical covid19 disease, or acute complications, hospitalized in the pasteur clinic of neuquén city from the beginning of the pandemic in the region until december 31, 2021. data were obtained retrospectively from information registered simultaneously with hospitalization in three databases (redcap, datatech and excel). . inclusion criteria * adult patients (over 18 years old) * suffering from acute infection by sars-cov2, diagnosed by pcr-real time, detection of viral antigen, specific antibodies with or clinical epidemiological criteria * hospitalized defined by attending physicians or referral (severe or critical according to nih) exclusion criteria * patients under 18 years of age. * convalescent from acute sars-cov2 infection and without evidence of a new event of reinfection. * outpatient management or hospitalization less than 24 hours for diagnosis and / or evaluation of severity or complications. sample selection method first patient was registered at the beginning of the pandemic in the region march 20, 2020) and is expected to recruit the las patient diagnosed in december 31, 2021. the recruitment is consecutive without other selection criteria.

Eligibility criteria:
inclusion criteria: * adult patients (over 18 years old) * suffering from acute infection by sars-cov2, diagnosed by pcr-real time, detection of viral antigen, specific antibodies with or clinical epidemiological criteria * hospitalization defined by attending or referral physician (severe or critical according to nih) exclusion criteria: * patients under 18 years of age. * convalescent from acute sars-cov2 infection and without evidence of a new event reinfection. * outpatient management or hospitalization less than 24 hours for diagnosis and / or evaluation of severity or complications.
neoadjuvant chemotherapy + herceptin in her2 positive stage ii-iii breast cancer patients

Conditions: Breast Neoplasm

Summary: the purpose of this study is to evaluate the effectiveness and tolerability of the combination of the following medications given every two weeks in her2 positive breast cancer patients: * trastuzumab (herceptin) * epirubicin (ellence) * cyclophosphamide (cytoxan) * docetaxel (taxotere)

this is an investigator-initiated, phase ii, non-randomized, single-arm, prospective treatment study. the study will consist of neoadjuvant treatment period (weeks 1 to 20), surgical evaluation period (weeks 20 to 24), and a post-surgical/follow-up period (approximately 3 years). subjects will be treated on an outpatient basis. neoadjuvant therapy will consist of epirubicin + cyclophosphamide given every 2 weeks for four cycles followed by a three week break. subjects will then receive docetaxel every two weeks for four cycles + trastuzumab (one loading dose) then maintenance dose every 2 weeks for 4 treatments.

Eligibility criteria:
inclusion criteria: * non-pregnant females =/\> 18 years of age * non-inflammatory breast cancer stage iia - iiic or high risk node negative * core biopsy of breast demonstrating invasive cancer and documented er/pgr receptor status * normal cardiac function and adequate hematologic function * human epidermal growth factor receptor 2 protein (her2) positive * no evidence of metastatic disease * ecog performance status 0 - 1 * women of childbearing potential must agree to using effective contraception while on treatment and for at least 3 months post-treatment exclusion criteria: * treated with other investigational drugs within 30 days * uncontrolled intercurrent disease or active infection * known sensitivity to e. coli-derived proteins or polysorbate 80 * psychiatric illness or social situation that would limit study compliance * pre-existing peripheral neuropathy \> grade 1 * cancer within 5 years of screening with the exception of surgically cured nonmelanomatous skin cancer; in-situ carcinoma of the cervix; or in-situ carcinoma of the breast * bilateral synchronous breast cancer * inflammatory breast cancer * women who are pregnant or breast feeding

Keywords: neoadjuvant chemotherapy her2 positive breast cancer stage ii - iii breast cancer
azd2066 neuropathic pain - mechanical hypersensitivity

Conditions: Neuropathic Pain; Mechanical Hypersensitivity

Summary: the purpose of this study is to investigate if 28 days of treatment with azd2066 compared to placebo can relieve the pain arising from the nervous system when the patients are touched by something that should not cause pain or have severe pain when they are touched by something that should only cause a little pain.


Eligibility criteria:
inclusion criteria: * provision of informed consent prior to any study specific procedures. * male or non-fertile females * painful symptoms due to neuropathic pain for a period of 3 months to 5 years, associated with mechanical allodynia and/or punctate hyperalgesia. exclusion criteria: * other pain that may confound assessment of neuropathic pain. * diagnosis of any severe neurological disease. * history of significant psychiatric disease/condition and/or history of psychotic disorders among first degree relatives.

Keywords: pain, mechanical hypersensitivity allodynia efficacy analgesia neuropathic