Kornimate/medical-research-clean huggingface dataset:
soft tissue assessment in screw-retained maxillary complete denture with electric welded framework versus casted

Conditions: Peri-Implantitis

Summary: comparing the changes in the soft tissue around the implants that will be joined by a metal framework either with electric welding or with the conventional casting method

as joining multiple implants by a metal framework considered a solid solution for edentulous arches , but in the same time the conventional method to weld this metal framework to the implants by casting technique in lab usually involves a several disadvantages eg. cost and time consuming in addition to laboratory errors, thus , this study aims to find another method to weld the metal framework intraorally by an electric welding device

Eligibility criteria:
inclusion criteria: * ages range from 45 to 65 years old. * absence of any medical disorder that could complicate the surgical phase or affect osseointegration. * the patients must be completely edentulous. * the patient must have enough bone height for implants minimum length of 10mm and a minimum diameter of 5 mm. * patients with good oral hygiene. * complete denture wearer. * adequate inter arch space for screw retained prosthesis. * absence of any intra-oral pathological condition. exclusion criteria: * patients with recent extraction(less than three months). * patients with inflamed ridge or candida infection. * patients with flappy ridge. * parafunctional habits.
molecular markers in thyroid cancer

Conditions: Thyroid Cancer

Summary: the purpose of this study is to evaluate how common gene mutations are in benign and malignant thyroid lesions.

the overall objective of this study is to evaluate the prevalence of molecular markers in patients with benign and malignant thyroid lesions. this study consists of: retrospective review of archived surgical pathology specimens at oregon health \& science university (ohsu) from patients with thyroid cancer or benign thyroid disease (nodules or goiter) who underwent thyroidectomy and/or neck dissection as standard of care. molecular markers will be evaluated on archived tissue. molecular markers will be correlated with clinical information extracted from ohsu medical records: histologic subtype of cancer, measures of tumor aggressiveness (capsular and angiolymphatic invasion, local invasion, lymph node and distant metastases, tnm stage(tnm classification of malignant tumours)) and clinical outcome (recurrence, distant metastases and death). patients with other malignancies presenting for standard of care services will have peripheral blood collected for dna, rna and buffy coat/white blood cells as a "positive" control for the dna/rna isolation techniques and mutation assays, as other cancers commonly express some of the same mutations. normals will have peripheral blood collected for dna, rna and buffy coat/white blood cells as a "negative" control for the dna/rna isolation techniques and mutation assays.

Eligibility criteria:
inclusion criteria: * age 1 - 100 * benign or malignant thyroid lesion, other malignancy or no thyroid abnormality * pathologic specimen available for analysis * ability to provide informed consent (for prospective study, part two) * age greater than age 18 (for normal controls) exclusion criteria: * patients without adequate data for analysis * histopathologic or cytopathologic diagnosis of for medullary thyroid carcinoma (not derived from the thyroid follicular epithelium), thyroid lymphoma * unwilling to participate or unable to provide informed consent

Keywords: thyroid nodule genetic mutation malignancy
eus-guided portal vein sampling for circulating tumor cells in pancreatic cancer patients

Conditions: Pancreatic Cancer; Pancreatic Adenocarcinoma

Summary: the study aims at evaluating the feasibility and safety of eus-guided portal circulation sampling for isolation, enumeration and profiling od circulating tumor cells (ctc) in pancreatic cancer patients. patients undergoing endoscopic ultrasound (eus) for cyto/histological characterization of the neoplasia will receive an additional fine needle aspiration sampling of a branch of the portal circulation to obtain a blood sample which will be processed for ctc enrichment, count and characterization.

prognostic stratification of patients with pancreatic ductal adenocarcinoma (pdac) is still suboptimal, relying only on imaging studies and carbohydrate antigen 19.9 to drive important treatment decisions (e.g. surgery versus neoadjuvant chemotherapy). circulating tumor cells (ctcs) have been poorly evaluated in this neoplasia as they are rarely detected in the peripheral blood, whereas they are more abundantly detected in the portal circulation below the hepatic filter. most pdac patients undergo endoscopic ultrasound (eus) for cyto/histological characterization of the neoplasia. eus-guided acquisition of portal blood for ctc evaluation has demonstrated its feasibility in preliminary studies without reducing the safety of the endoscopic procedure. the study aims at collecting portal blood from pdac patients under eus-guidance to evaluate whether concentration and characterization of ctcs has a prognostic significance and can aid in decision making. a paired peripheral blood sample will be acquired for comparison. samples will be processed to obtain microfluidic enrichment of ctcs and stained with immunofluorescent antibodies for exclusion of hematopoietic cells and specific identification of ctcs, which will then be counted to obtain the blood concentration expressed as number of cells per 7.5 ml of blood. patients will be followed every 60 days for a maximum of 24 months to assess the evolution of primary disease and clinical status.

Eligibility criteria:
inclusion criteria: * patient with a pancreatic solid lesion undergoing eus with a rapid on-site confirmation of a pancreatic ductal adenocarcinoma * patients primarily followed within san raffaele institute exclusion criteria: * history of active non-pancreatic cancer * coagulopathy (inr \> 1.5; platelets \< 70.000/ul) or use of non-withdrawable anticoagulant or antiplatelet * known history or endosonographic signs of portal hypertension * extensive invasion of portal vein precluding needle maneuvers * pregnancy and breastfeeding

Keywords: endoscopic ultrasound eus portal blood circulating tumor cells fine needle aspiration
the effect of smoking and non-surgical periodontal treatment on gingival crevicular fluid cyclophilin a and emmprin levels

Conditions: Smoking; Periodontitis; Non-surgical Periodontal Treatment

Summary: this study aimed to investigate the effect of smoking and non-surgical periodontal treatment on gingival crevicular fluid cypa and emmprin levels in patients with periodontitis. twenty-eight patients with periodontitis (14 non-smoker and 14 smoker) and 30 control subjects (15 non-smoker and 15 smoker) were included into the study. non-surgical periodontal treatment was applied to all periodontitis patients. periodontal parameters and gcf cypa and emmprin levels were evaluated during 3 months following non-surgical periodontal treatment. gcf cypa and emmprin levels were analyzed by elisa.


Eligibility criteria:
inclusion criteria: * generalized periodontitis with stage iii-iv \& grade b * no systemic and periodontal diseases * smokers (minimum 10 cigarettes per day for at least ten years) * non-smokers (never smoked) exclusion criteria: * systemic diseases * infectious diseases * pregnancy or lactating * having periodontal treatment during the last 6 months * having antibiotic treatment within the past 3 months * former smokers
study the effect of danggui buxue tang on menopausal symptoms

Conditions: Menopause

Summary: this study is to examine the effect and safety of the study drug,danggui buxue tang, on menopausal symptoms of hot flushes and sweating and to determine whether the patient's quality of life will be improved.


Eligibility criteria:
inclusion criteria: * follicle stimulating hormone (fsh), luteinizing hormone (lh), oestradiol in the menopausal range (fsh\>18 iu/l, lh\>12.6 iu/l, and e2\< 361 pmol/l). * patients with amenorrhoea for more than 12 months exclusion criteria: * patients with a history of using any form of hormonal replacement therapy within 8 weeks * patients with a history of using chinese medicine or other therapies which may affect the outcome within 8 weeks * patients who in the judgment of the investigator will be unable to comply with protocol requirements * patients with significant\*\* gastrointestinal, renal, hepatic, bronchopulmonary, neurological, cardiovascular, breast or endometrial carcinoma, or allergic diseases * patients with uncontrolled hypertension * patients with undiagnosed vaginal bleeding * patients with a history of significant drug hypersensitivity

Keywords: menopausal traditional chinese medicine
online re-intervention on eating behaviour and bmi on obese hypertensive patients

Conditions: Hypertension; Overweight and Obesity

Summary: this research will constitute a 3-year follow-up that includes a re-evaluation and re-intervention of overweight or obese adults suffering from hypertension, who already participated in a similar programme with the same objectives 3 years ago. patients will be recruited in the hypertension unit of a public hospital and assigned to a experimental group. the evaluation will include: eating behaviour, body mass index (bmi) and physical activity levels.

hypertension incidence and overweight or obesity related, constitute a worrying public health problem nowadays. evidence indicates that, despite the existence of several factors involved in their etiology, diet and physical activity play a particularly important role in the treatment and prevention of obesity and associated disorders. however, interventions for the treatment of obesity encounter some environmental and personal barriers, specifically problems or deficits in motivation. these barriers sometimes make it difficult to implement intervention strategies. in this sense, there is an important agreement about the need to generate alternatives and strategies which promote intrinsic motivation, self-regulation and self-efficacy as fundamental variables which have a direct relationship with the adherence and success of obesity treatments. to achieve this, information and communication technologies (icts) are a very promising alternative, as they can provide personalised feedback and can be flexibly adapted to each user. in addition, icts also present other important advantages, especially their excellent cost-benefit ratio, and the possibility of increasing the efficiency of the interventions, since they allow to reach a greater number of users at a lower cost. this research will constitute a 3-year follow-up that includes a re-evaluation and re-intervention of overweight or obese adults suffering from hypertension, who already participated in a similar programme with the same objectives 3 years ago. patients will be recruited in the hypertension unit of a public hospital and assigned to a experimental group. the evaluation will include: eating behaviour, body mass index (bmi) and physical activity levels.

Eligibility criteria:
inclusion criteria: * hypertension. * overweight or obesity (25 ≤ bmi ≤ 35 kg/m2). * aged between 18-65 years. * being a participant of the program 3 years ago. exclusion criteria: * not having access to the internet or lack of information about it. * treatment with more than 3 antihypertensive drugs. * meet the criteria of the dsm-iv-tr of a food disorder. * presenting some type of severe psychiatric disorder. * disability that prevents or hinders physical exercise. * receiving some treatment for weight loss.

Keywords: hypertension obesity internet re-intervention eating behaviour physical activity
characterization and risk factors of folliculitis after hair transplantation

Conditions: Folliculitis

Summary: we retrospectively reviewed 1317 patients who had undergone ht and completed 9-month follow-up between january 2018 and june 2021 at 4 medical centers. the incidence of postoperative folliculitis and the patient demographics were assessed. logistic regression analysis was used to identify the risk factors, and the characteristics of different types of folliculitis were compared.

postoperative folliculitis is a common complication after hair transplantation (ht) and requires effective preventive interventions. this study aimed to characterize postoperative folliculitis and determine the risk factors in patients underwent ht. the study was conducted at 4 clinical sites: nanfang hospital of southern medical university, the first affiliated hospital, zhejiang university school of medicine, the affiliated hospital of guilin medical university, and peking university third hospital. data of 1317 patients who had undergone ht and completed a 9-month follow-up from january 2018 to june 2021 were collected. the incidence of postoperative folliculitis and the patient demographics were assessed. logistic regression analysis was used to identify the risk factors, and the characteristics of different types of folliculitis were compared.

Eligibility criteria:
inclusion criteria: - 1. healthy adults between the ages of 18 \~ 60 2. patients suitable for autologous hair transplantation according to "the standard of hair transplantation" exclusion criteria: 1. coagulation disorders, pregnancy and lactation, immunosuppression 2. with severe mental and psychological illness, impairment of body image 3. all kinds of immune-related alopecia in the progressive active stage 4. patients judged by the investigator to be unsuitable for this study

Keywords: folliculitis hair transplantation follicular unit extraction
mometasone furoate cream reduces acute radiation dermatitis in head and neck squamous cell carcinomas' patients

Conditions: Early Radiation Dermatitis

Summary: radiation dermatitis is an acute effect of radiation therapy,especially in the neck skin of head and neck squamous cell carcinomas' patients.the investigators wanted to confirm the benefit of mometasone furoate (mf) in preventing acute radiation reactions, as shown in a previous study.

a randomized,self-comparative controlled trial was undertaken comparing mf cream with no cream administered from the first day of treatment for 5-6 weeks to prevent radiation dermatitis of neck during radiation therapy to the head and neck squamous cell carcinomas' patients. one side of patients' neck will begin to use mf cream from the first day of radiation therapy, while the other side accept no preventive measures.

Eligibility criteria:
inclusion criteria: * pathological diagnosis for head and neck squamous cell carcinomas and * going to have radiotherapy. exclusion criteria: * pregnant, * lactating women, * infants, * elderly people with atrophy skin, * allergic constitution patients, * the corresponding parts of 5 radiotherapy skin ulceration or infection and * allergic patients to mometasone furoate cream.
radiotherapy for extracranial oligometastatic breast cancer

Conditions: Breast Cancer Metastatic

Summary: more and more evidence suggests that local radiotherapy can improve the outcomes for patients with oligometastatic disease. the purpose of this study is to assess the impact of radiotherapy, compared with standard systemic therapy alone, on survival, local control and toxicities in patients with extracranial oligometastatic breast cancer. eligible patients are randomized in a 1:2 ratio between the control arm (standard systemic therapy), and the wlrt arm (standard systemic therapy + radiotherapy). randomization will be stratified by three factors: visceral metastasis (yes vs.no), number of metastases(≤2 vs. \>2), hormone receptor(positive vs. negative). sbrt technique is preferred. during and after radiotherapy, the patients are followed and the efficacy and toxicities of radiotherapy are evaluated.


Eligibility criteria:
inclusion criteria: * 18-70 years old * ecog performance status 0-2. * newly-diagnosed or metachronous extracranial oligometastatic diseases confirmed by pathology or imaging, with or without locoregional disease (biopsy of metastasis is preferred). * total number of locoregional and metastatic lesions of 1-5 , the maximum diameter of lesions ≤5 cm and at least one lesion could be evaluated by recist1.1. * have received or plan to receive systemic therapy. * all lesions could be safely treated by radiotherapy. * life expectancy \> 6 months. * have adequate organ function. exclusion criteria: * have metastases in the central nervous system. * have indications for palliative radiotherapy to reduce symptoms, such as pain, bleeding, obstruction, and pending fractures caused by the tumor. * have moderate/severe liver dysfunction (child pugh b or c) from liver metastases, . * malignant pleural effusion * unable to tolerate radiotherapy due to serious comorbidity * have received prior radiotherapy for target area * pregnant or lactating women

Keywords: breast neoplasm oligometastases radiotherapy stereotactic ablative radiotherapy
combined glucocorticoid adrenergic therapy for wheezy preschool children

Conditions: Wheeze

Summary: the investigators goal is to conduct a pilot randomized controlled trial (rct) whose purpose is to determine the feasibility of a randomized trial designed to determine if either inhaled beclomethasone or a combination of inhaled beclomethasone/salbutamol (clenil compositum) are superior to placebo in treating pre-school aged children with an acute wheezing episode.


Eligibility criteria:
inclusion criteria: 1. children 12-60 months of age 2. wheeze on auscultation 3. mild respiratory distress as measured by a score of \< 3 on the pediatric respiratory assessment measure (pram) 4. discharged home after evaluation by their ed physician. exclusion criteria: 1. treatment with oral or parenteral corticosteroids in the last 14 days 2. treatment with more than 2 doses of inhaled corticosteroids in the previous seven days 3. presence of a severe co-morbidity such as bronchopulmonary dysplasia, cystic fibrosis, congenital heart disease, adrenal disorder or immune deficiency 4. previously enrolled into this study or concurrently enrolled in another intervention trial 5. lack of telephone access or presence of a significant language barrier

Keywords: wheeze asthma randomized trial pre-school aged children
kinetic analysis due to foot dysfunction

Conditions: Amputation; Neuropathy;Peripheral

Summary: the aim of the current study is to examine the biomechanical changes of gait kinetics in patients with either partial foot amputation or peripheral neuropathy


Eligibility criteria:
inclusion criteria: * partial foot amputees who didn"t receive physiotherapy and don"t use prosthesis. patients with pn grade (1-2) age 40-65y both sexes. walking independently however, no walking aids were used during the testing procedures exclusion criteria: * foot amputation levels more proximal than tarso metatarsal joint. less than 4 months after partial foot amputation. foot amputees who use prosthesis or suffer from phantom pain. active foot problems; ulcer, infection, or gangrene. patients with pn who received physiotherapy or injections like puerarin major surgeries in lower limb that could affect either gait or balance like acl, hip/knee arthroplasty spine problems that could affect either gait or balance history of ankle sprain. pathologies such as skin diseases, inflammatory diseases, congenital diseases, or neurological diseases rather than pn. fractures or dislocations. symptomatic degenerative changes that require medications. bmi over 35. inability of walking independently
chemotherapy and tislelizumab with split-course hfrt for locally advanced rectal cancer

Conditions: Rectal Cancer; Radiation Oncology

Summary: the question of how to administer adequate chemotherapy and immunotherapy to synchronise hypofraction radiotherapy （hfrt） treatment strategy to maximise the benefits of neoadjuvant therapy for the improved prognosis of patients with locally advanced rectal cancer (larc).we aimed to study whether chemotherapy and tislelizumab plus split-course hfrt results in better outcomes in larc patients.

prior to analyzing continuous variables, the statistical normality of the data will be determined. the differences between the main variables will be compared by using the analysis of variance. a comparison of data on categorical variables will be carried out by χ2 tests or fisher's exact tests. the os and pfs was estimated using the kaplan-meier method. pfs and os will be compared using the log-rank test. in cases where variables must be adjusted, we will use the proportional hazard cox regression model. p values for all analyses will be based on using a significance level of 0.05.

Eligibility criteria:
inclusion criteria: * treatment-naïve patients with operable locally advanced cancer (larc, t3-4 and/or n+) * pathologically diagnosed as rectal adenocarcinoma * male or non-pregnant female * age: 18-70 years old * hematology examination：i. white blood cell count ≥4×10\^9/l;ii. neutrophils ≥1.5×10\^9/l;iii. platelet count ≥100×10\^9/l;iv. hemoglobin ≥9g/l * blood biochemical examination: total bilirubin, ast, alt≤2.0×upper limit of normal; creatinine≤1.5×upper limit of normal * functional status: ecog score 0-1 points or kps score ≥70 points * obtain the patient's informed consent exclusion criteria: * pathologically diagnosed as non-adenocarcinoma * age\> 70 years old * patients with recurrence and distant metastasis * have a history of other malignancies * have had radiotherapy and/or chemotherapy * pregnant or breastfeeding women * mentally disordered * patients with severe heart, liver, and kidney damage * non-compliance or the investigator believes that the patient cannot complete the entire trial treatment

Keywords: chemotherapy tislelizumab split-course hypofraction radiotherapy locally advanced rectal cancer
pharmacology and physiology of the lower urinary tract

Conditions: Urologic Diseases

Summary: the function of the lower urinary tract is simple - urine storage and voiding. however, despite this simplicity of function, the control of the lower urinary tract is a rather complex, multilevel process (urothelium, detrusor, peripheral nerves, spinal cord and higher cerebral centres) and the mechanisms involved remain poorly elucidated. this study is designed to gain a more in depth understanding of the lower urinary tract function. using bladder biopsies, tissue staining for characteristic markers present on nerves and other cells will be performed. we hypothesize that certain markers are altered in disease and turn back towards the control level of healthy people or patients with successful medical treatment.


Eligibility criteria:
inclusion criteria: * patients with lower urinary tract dysfunction * controls with normal lower urinary tract function exclusion criteria: * age \< 18 years old * pregnancy

Keywords: lower urinary tract physiology pathology immunohistochemistry urinary bladder