Kornimate/medical-research-clean huggingface dataset:
effects of virtual music therapy on burnout syndrome among healthcare workers in tertiary hospital

Conditions: Burnout, Psychological; Burnout, Professional

Summary: the goal of this clinical trial is to learn about burnout syndrome among healthcare workers in tertiary hospital. the main questions it aims to answer are the effects of music therapy on burnout syndrome among healthcare workers. participants will get examined using maslach burnout inventory-human service survey and heart rate variability device before and after music therapy intervention.

the goal of this clinical trial is to learn about burnout syndrome among healthcare workers in tertiary hospital. the main questions it aims to answer are what kind of music therapy used as a non-pharmacological intervention for health workers with burnout syndrome, maslach burnout inventory and heart rate variability score in health workers with burnout syndrome before and after music therapy, and does music therapy improve maslach burnout inventory and heart rate variability score in health workers with burnout syndrome. participants will get examined using maslach burnout inventory-human service survey and heart rate variability device before starting the music therapy. music therapy will be conducted in two groups, one using 3 session a week for 4 weeks and the second group will get 5 session a week for 2 weeks. after all the session are done, participant will get their maslach burnout inventory and heart rate variability score evaluate. researchers will compare the results with neutral group without any music therapy to see if there are any positive effects of music therapy to maslach burnout inventory and heart rate variability score.

Eligibility criteria:
inclusion criteria: * agreed to participate in this study by signing an informed consent sheet * age above 18 years old * working as a healthcare workers at rsup dr kariadi and rsupn dr cipto mangunkusuma, these include doctors, nurses, and other supporting healthcare workers exclusion criteria: * refuse to participate in this research * have chronic diseases such as cancer, thyroid, and cardiovascular disease * taking drugs that affect central nervous system * hearing loss and disorder * psychosis disorder * pregnant women * does not like music
incidence of hemidiaphragmatic palsy after interscalene block

Conditions: Phrenic Nerve Paralysis

Summary: primary objective of this study is to find out the incidence of hemi-diaphragmatic palsy associated with interscalene block done under ultrasound guidance. primary hypothesis: • there is an incidence of hemidiaphragmatic palsy ranging fron 33-100 % after an interscalene block. secondary hypothesis * the incidence of hemidiaphragmatic palsy is much less than 33% when the block is done using ultrasound. * the incidence of hemi-diaphragmatic palsy is directly proportional to volume of local anaesthetic injected. * the incidence of hemi-diaphragmatic palsy is directly proportional to concentration of local anaesthetic injected.

patients of either sex belonging to american society of anesthesiologists status 1-3 scheduled for elective shoulder surgery as an outpatient basis, planned for an interscalene block will be included in this study over a period of one year. potential patients will be identified from the surgeons' list. the pi or one of the co-investigators will contact them in the surgical day care in the morning of surgery and will be given information about the study. documented informed consent will be obtained. after obtaining informed consent, they will be examined for their diaphragm position using an ultrasound prior to block placement . all patients will have the block initiated in the block room using standard monitors and sedation as per the standard practice in this hospital. the patients will undergo an ultrasound examination for their diaphragm position 5 mins and 10 mins after the completion of the nerve block. ipsilateral ( same side as the block) and contralateral ( opposite side of block) hemi-diaphragmatic excursion will be measured with the patients in supine position during quiet inspiration ,deep inspiration and forceful sniff. in addition, bedside spirometry using a compact spirometer will be performed and fvc, fev1 and pefr measurements will be performed.the oxygen saturation and any evidence of dyspnea or shortness of breadth will be noted at the above mentioned intervals after the completion of the block. all patients will receive general anesthesia in the operating room. the patient will receive iv opioids during the procedure if required. the above mentioned data will be collected postoperatively in the recovery room 30 mins, after arrival.

Eligibility criteria:
inclusion criteria: control group: age between 18 - 80 years old elective shoulder surgery same day discharge inform consent signed exclusion criteria: ongoing major psychiatric problems narcotic abuse/ drug dependency mental impairment / inability to cooperate with postoperative evaluation/inability to give informed consent -

Keywords: interscalene block hemidiaphragm palsy
comparison of regimens mpib, cipcea, pcea

Conditions: Breakthrough Pain

Summary: epidural analgesia is the gold standard of pain relief for labour pain. despite this, more than 50% of parturients continue to experience pain leading to suffering and increased caregiver workload. women who have increased pain tend to have lower successful patient bolus demands when patient controlled epidural analgesia (pcea) is utilised and have dysfunctional labour requiring obstetric intervention such as caesarean or instrumental delivery. labour pain often escalates and worsens as labour progresses requiring an individualized, variable, flexible analgesic regimen. bolus epidural administrations have been shown to improve uniform spread of local anaesthetics with better pain relief, compared to fixed background infusions.

the research team developed two novel epidural delivery regimens: computer-integrated pcea (cipcea) and modified programmed intermittent bolus (mpib) focused on individualization of analgesic requirements. this phase 3 double-blinded randomized controlled trial will compare the two novel regimens, and each with conventional pcea with basal infusion (bi), in reducing breakthrough pain (failure of the regimen to provide adequate pain relief, necessitating unscheduled epidural supplementation) incidence as the primary outcome in nulliparous term women requesting labour epidural analgesia. in addition, a discrete choice experiment (dce) in the format of a survey will be administered to estimate the women's preferences in treatment attributes related to epidural analgesia, including control over epidural dosage, chance of having breakthrough pain, motor block, instrumental delivery and out-of-pocket cost for epidural analgesia. we will also look into the association model for breakthrough pain that would take into account pre-delivery factors to better understand the mechanism of breakthrough pain during labor process.

Eligibility criteria:
inclusion criteria: 1. healthy (asa physical status 1 and 2) nulliparous parturients at term (≥36 weeks gestation); 2. singleton foetus 3. early labour (cervical dilation ≤5cm) 4. request labour epidural analgesia 5. at least 21 years of age exclusion criteria: 1. parturients with multiple pregnancies 2. non-cephalic foetal presentation 3. obstetric (e.g. pre-eclampsia, premature rupture of amniotic membranes, gestational diabetes on insulin) and uncontrolled medical (e.g. cardiac disease) complications 4. have contraindications to neuraxial blockade or have received parenteral opioids with the last 2 hours.

Keywords: breakthrough pain
pcr technique to identify methicillin-sensitive and methicillin-resistant staphylococcus aureus in nasal and respiratory tract samples

Conditions: Thoracic Surgery

Summary: in patients on mechanical ventilation, it is not known whether the identification of s. aureus in lrt samples improves the performance of its nasal detection. to assess the mssa or mrsa carrier status of patients requiring mechanical ventilation for more than 48 hours after major heart surgery: comparing the performance of the diagnostic technique xpert® sa nasal complete assay in nasal swab and lrt samples.

patients undergoing heart surgery require ventilation for more than 48 hours. these patients, placed on mechanical ventilation for a median of 7 days, will be followed weekly until their discharge from hospital. we estimate we will need 500 determinations. samples will be obtained according to usual clinical practice. thus, rather than discarding a sample, it will be subjected to the two laboratory diagnostic techniques (conventional culture and the xpert® assay). no patient will be subjected to any procedure outside that of routine clinical practice. patient with a tracheal tube in whom nasal and lrt secretions can be simultaneously obtained. patients may also be included if lrt samples can be obtained via a different approach (tracheostomy, fibrobroncoscopy etc.).

Eligibility criteria:
inclusion criteria: * adults (≥ 18 years) * signed informed consent * patient admitted to the hs-icu before or after undergoing heart surgery * patient on mechanical ventilation for \>2 calendar days on the date of event (suspicion of lrt infection) ), taking the day of ventilator placement as day 1 * patient with a tracheal tube in whom nasal and lrt secretions can be simultaneously obtained. patients may also be included if lrt samples can be obtained via a different approach (tracheostomy, fibrobroncoscopy etc.).
the progirls study

Conditions: Delinquency; HIV Risk; Substance Use; Trauma Exposure

Summary: girls in the juvenile justice system who have high rates of delinquency, drug abuse, and trauma are particularly at risk for engaging in risky sexual behavior and for contracting hiv/aids or other sexually transmitted infections (stis). no effective prevention programs for girls who have this combination of behaviors is known to exist at this time. researchers are developing, assessing, and implementing a family-centered prevention program to decrease girls' participation in the risky behaviors associated with the spread of hiv and stis. the program also includes a group-based training and support program for parents.

this study aims to test an intervention to reduce hiv/sti risk behavior among girls in the juvenile justice system with the triple-threat risk of delinquency, drug abuse, and trauma. this is a competing continuation of the proteens study (preventing drug abuse \& hiv/aids in delinquent youths: an integrated intervention) which focused on testing a family-centered intervention for treating hiv risk, drug use, and delinquency in boys. the current study will adapt the proteens intervention for girls. girls and their parent(s) will be randomly assigned to either a family-centered intervention condition (int; n = 100) or to an active comparison condition (n = 100) consisting of group therapy and case management (gcm). the int condition will consist of individually administered hiv preventive intervention for adolescent girls involved in the juvenile justice system that integrally addresses delinquency, drug abuse, and trauma exposure, along with group-based training and support for parents. the girl and parent components will run concurrently for three months. the gcm condition will consist of group therapy and case management for girls provided as usual by the juvenile justice department. we will examine intervention effects on proximal outcomes measured at 12 months, the effects of childhood adversity on proximal outcomes, and the mediation of intervention effects. longer term outcomes will be measured at 24 months. data will be collected through in-person interviews and questionnaires from focal participants and their parents, official arrest records, and urinary analysis.

Eligibility criteria:
inclusion criteria: * female, age 13-18 years * living in lane county, oregon * living at home (biological/adoptive, foster, or other relative care) * at least one criminal referral and on probation or a formal accountability contract with the juvenile justice system * documented drug use from juvenile justice risk assessment * traumatic exposure * no imminent plans to be placed in out-of-home care exclusion criteria: * meet criteria for posttraumatic stress disorder
superiority study for pain treatment after cesarean

Conditions: Pain

Summary: the purpose of this study is to investigate adequate pain treatment for patients after cesarean. in this study oral opioids were compared to intravenous opioids as they are supposed to provide superior pain control.

pain management after cesarean is an important topic for women. pain during and after surgery is their greatest concern. after surgery quick mobilization is important to take care of the newborn. when using a patient controlled analgesia (pca) device mobilization is limited and women can not meet their expectations to take care of the newborn. oral analgesia in comparison offers superior patient satisfaction. this trial was conducted to investigate the effectiveness of both treatment options and improve patients pain management and overall content after cesarean.

Eligibility criteria:
study participation was offered to all pts. aged \> 18 years in labor and delivery for elective or unplanned secondary cesarean in the 37th or higher week of gestation. inclusion criteria: * cesarean in spinal anesthesia, * no history of opioid or metamizol treatment * written consent * ability to use a patient-controlled analgesia device exclusion criteria: * cesarean in general anaesthesia * use of peridural catheter for pre-, peri- or post cesarean analgesia * additional post cesarean metamizol use * allergy/hypersensitivity to morphine, oxycodon, acetaminophen or ibuprofen * chronic use of general anaesthesia * history of known pain syndrome

Keywords: pain after cesarean visual analog scale oxycodon piritramid
comparison of mcgrath and macintosh laryngoscope for dlt intubation

Conditions: Intubation; Difficult; Thoracic Diseases; Intubation Complication

Summary: the investigators previous study showed that mcgrath series 5 videolaryngoscope is an alternative tool for double-lumen tube intubation. but it is not determined about the advantages and disadvantages of mcgrath series 5 videolaryngoscope for double-lumen tube intubation, compared with traditional macintosh laryngoscope.

the investigators designed a randomised controlled study to compare of mcgrath series 5 videolaryngoscope and macintosh laryngoscope for dlt intubation.

Eligibility criteria:
inclusion criteria: * adult patients * thoracic surgery required one lung ventilation exclusion criteria: * difficult ventilation * emergent operation

Keywords: videolaryngoscope double lumen intubation
ganfort® in patients with primary open angle glaucoma or ocular hypertension who are insufficiently responsive to monotherapy

Conditions: Glaucoma, Open-Angle; Ocular Hypertension

Summary: this is an observational study of patients diagnosed with primary open angle glaucoma (poag) or ocular hypertension (oht) who are insufficiently responsive to monotherapy and who are prescribed ganfort® (fixed combination of 0.3 mg bimatoprost and 5 mg timolol) by their physician.


Eligibility criteria:
inclusion criteria: * diagnosis of primary open angle glaucoma or ocular hypertension * prescribed ganfort® (fixed combination 0.3 mg bimatoprost and 5 mg timolol) exclusion criteria: * none
international prospective multicentre study that evaluate the sentinel lymph node detection rate in patients with first local recurrent scamous cell carcinoma of the vulva.

Conditions: Recurent Vulvar Carcinoma

Summary: acronym: vulca-node study title: sentinel node biopsy in relapsed vulvar cancer primary objetive: to evaluate the sln detection rate in the first recurrent vulvar carcinoma setting. secondary objetives: * to compare the utility of different tracers in the detection of sln for recurrent disease and the injection pattern. * to evaluate the surgical complications rate. * to analyze the nodal status by ultrastaging . * to assess the disease free and overall survival at 24 months from the first recurrence, as well as the dissemination pattern after the procedure. study design: international prospective multicentre study inclusion criteria: * first local recurrent squamous cell carcinoma of the vulva (scc). * unifocal, smaller or equal than 4 cm vulvar tumor not involving urethra, vagina or anus. * no distant or groin metastasis. * to be able to understand the study and sign informed consent. * over 18 years old. * to be able to undergo planned follow up. exclusion criteria: * multifocal recurrent disease of the vulva. * previous bilateral ifl. * synchronous, non-curable second malignancy. timing: 4 years


Eligibility criteria:
inclusion criteria: * first local recurrent squamous cell carcinoma of the vulva (scc). * unifocal, smaller or equal than 4 cm vulvar tumor not involving urethra, vagina or anus. * no distant or groin metastasis. * to be able to understand the study and sign informed consent. * over 18 years old. * to be able to undergo planned follow up. exclusion criteria: * multifocal recurrent disease of the vulva. * previous bilateral ifl. * synchronous, non-curable second malignancy.
phase ii trial: upar-pet/ct for prognostication in head- and neck cancer

Conditions: Head and Neck Cancer

Summary: head and neck cancer (hnc) is the 6th most common cancer worldwide. in the last decade, there has been made substantial improvements in diagnosis, staging and treatment of hnc. the overall survival has improved, but for some subgroups it is unchanged and therefore new prognostic and surveillance methods are warranted. one of the hallmarks in cancer is the ability to invade the surrounding tissue and metastasize. studies have shown that the urokinase proteolytic plasminogen activator (upa) and its receptor (upar) are present at the very front of the invasive tumor and they are considered essential in cancer invasion and metastasis. consequently, an upar-targeted tracer offers a very promising target for functional pet imaging and may be a stronger prognostic marker compared to routine fdg-pet/ct. we wish to clarify how upar-pet/ct correlate to patient outcome compared to routine fdg-pet/ct in patients with hnc in the pharynx, larynx and oral cavity, who are referred to curative intended radiotherapy. in this project all participants have an upar-pet/ct scan performed before initiation of the routine radiotherapy and the prognostic efficacy is determined by assessment of the recurrence rate and mortality at routine clinical follow-up.

in this study all included patients with head and neck cancer (hnc) have an upar-pet/ct scan performed before the initiation of the curative intended radiotherapy. after the radiotherapy treatment the patients attend the routine clinical follow-up programme at rigshospitalet to follow the loco-regional control, signs of metastasis and the overall survival. these relapse- and survival parameters will be correlated to the suvmax, suvmean and the tnm stage obtained from the upar scan and will be compared to the findings on the routine fdg scan to clarify which tracer is the strongest prognostic marker in hnc. if any previous tissue samples have been taken from the tumour before the patient enters the study the upar immunohistopathology of the tissue sample will be compared to the upar-pet/ct findings. we will not perform any biopsies or tissue samples in this study.

Eligibility criteria:
inclusion criteria:the patient * has a diagnosis of biopsy-verified cancer of the pharynx, larynx or oral cavity * is referred to curative intended radiotherapy * understands the given information and has given informed consent and * age above 18 years. exclusion criteria: pregnancy, lactation/breast feeding, age above 85 years, obesity (bodyweight above 140 kg), small cancers of the larynx (1a,1b), allergy to 68ga-nota-ae105, metastasis on fdg-pet/ct, other previously known cancers, claustrophobia. -

Keywords: molecular imaging upar-pet/ct head and neck cancer curative intended radiotherapy
effects of anesthetic infusion on the amplitude of motor evoked potential in pediatrics undergoing tethered spinal cord surgeries

Conditions: Tethered Cord

Summary: the tethered spinal cord is a common pathology in pediatric neurosurgery. intraoperative neurophysiologic monitoring (iom) has gained popularity over the past two decades as a clinical discipline that uses neurophysiologic techniques to detect and prevent iatrogenic neurologic injuries. iom techniques are extensively used in adult neurosurgery and, in their principles, can be applied to the pediatric population. inhalational agents cause a dose-dependent reduction in meps and are arguably considered incompatible with effective neurophysiological monitoring(5) for this reason, total intravenous anesthesia (tiva), using iv anesthetics (propofol or ketamine) and opioids (fentanyl or remifentanil), is commonly used in spinal surgeries under meps monitoring

a combination of ketamine and dexmeditomidine has several benefits in terms of hemodynamic stability, absence of respiratory depression, postoperative analgesia, and recovery. (11) ketamine could prevent the decrease of blood pressure and heart rate which had been observed with dexmedetomidine. in addition, dexmedetomidine could prevent the increase of blood pressure and heart rate, salivation, and physiological emergence reaction from ketamine. this combination was not previously used in this type of procedure except in a case report performed by rozzana penny who had used dexmedetomidine and ketamine infusion during scoliosis repair surgery with somatosensory and motor evoked potential monitoring in 15 years old female.(10) evoked potentials are highly sensitive to fluctuations in physiological parameters such as peripheral and core body temperature, arterial blood pressure, hematocrit, etc. keeping in view all the above factors we plan this study to compare the effect of the combinations of propofol and fentanyl versus the combination of ketamine and dexmedetomidine and fentanyl in producing a minimum effect on mep amplitude and on hemodynamic stability during the surgery.

Eligibility criteria:
inclusion criteria: * children with asa i and ii presented to abu elreesh hospital for untethered spinal cord surgery. exclusion criteria: * children with neuromuscular diseases or congenital scoliosis. * children with growing rod distraction surgery. * children with american society of anaesthesiologists (asa) physical status iii, iv * children with preoperative use of antidepressant or anticonvulsant medications. * children with a known history of drug allergies.