Kornimate/medical-research-clean huggingface dataset:
fluorescent cholangiography in acute cholecystitis

Conditions: Acute Cholecystitis

Summary: currently, there is limited scientific evidence regarding the effectiveness of fluorescent cholangiography in emergency cholecystectomy for acute cholecystitis. the primary aim of this study was to assess the efficacy of near-infrared fluorescent cholangiography to detect extrahepatic biliary anatomy in different severity degrees of acute cholecystitis.

the study aims to to evaluate the efficacy of near-infrared fluorescent cholangiography for real-time visualization of the extrahepatic biliary tree (cystic duct, common hepatic duct, cystic duct-common hepatic duct junction, common bile duct and any accessory or aberrant ducts) in emergency laparoscopic cholecystectomy before and after hepatocystic triangle dissection and in different degrees of severity of acute cholecystitis according to the american association of surgery for trauma (aast) classification, specifically distinguishing between non-gangrenous (grade i) and gangrenous or complicated (grades ii-v) forms. for intra-operative fluorescent cholangiography, 2.5 mg indocyanine green (icg) was administered intravenously 45-60 min prior to surgery, according to the recent guidelines from the international society for fluorescence guided surgery. all the operations were performed by the same team of surgeons. near-infrared fluorescent cholangiography was performed by using stryker's fluorescence imaging system (stryker, portage, miami, usa). near-infrared fluorescent cholangiography was performed at three defined time point during laparoscopic cholecystectomy: (i) following exposure of calot's triangle, prior to any dissection; (ii) after partial dissection of calot's triangle; (iii) after complete dissection of calot's triangle, according to the "critical view of safety" method.

Eligibility criteria:
inclusion criteria: * patients with a clinical and radiological (abdominal ultrasound and/or computed tomography) diagnosis of acute cholecystitis based on the revised tg18 who underwent laparoscopic cholecystectomy within 24-72 hours from the onset of symptoms; * patients with asa score of 1-3; exclusion criteria: * patients with a known allergy to indocyanine green; * asa score 4-5; * patients deemed non-operable via laparoscopic approach due to high cardio-respiratory risk; * previous surgical interventions on the biliary tract; * history of liver cirrhosis or severe liver disease; * ongoing pregnancy or breastfeeding.

Keywords: acute cholecystitis emergency laparoscopic cholecystectomy near-infrared fluorescent cholangiography aast classification
effects of standing at different angles on transpulmonary pressure

Conditions: Pulmonary Disease

Summary: effects of standing at different angles on transpulmonary pressure

objective: to study the effect of different standing angles on cross-lung pressure.background: long-term bed rest in icu patients leads to upward movement of diaphragm and increased intrathoracic pressure in mechanically ventilated patients, resulting in lower cross-lung pressure. if the end-expiratory cross-lung pressure is negative, lung tissue compression and atelectasis will occur.standing can lower the diaphragm, improve the pressure across the lungs, and improve ventilation.selection methods: patients with invasive mechanical ventilation in the icu, on the premise of stable hemodynamics, with the aid of electric bed training in standing in different angles, start from 20 degrees, 5 degrees up every five minutes, the largest up to 80 degrees, each angle across the pulmonary pressure, die cavity ratio, tidal volume and breathe out carbon dioxide at the end of the record, and record whether low blood pressure, an accident in the process of take off the tube and other adverse reactions.

Eligibility criteria:
inclusion criteria: * the age is ≥ 18 years old; * the hemodynamics is stable; * 50 \< heart rate \< 120 beats / min ; * 90 \< systolic blood pressure \< 200mmhg ; * 55 \< mean arterial pressure \< 120mmhg; * do not increase the dose of pressor drugs for at least 2 hours; * intracranial pressure is stable and there are no seizures within 24 hours; * the respiratory state is stable; * the patient's finger pulse oxygen saturation ≥ 88%; * 10 \< respiratory frequency \< 35 beats / min. exclusion criteria: * pregnancy; * acute cardio-cerebrovascular events; * spinal or limb fractures; * active bleeding.
study to assess batoclimab in participants with active thyroid eye disease

Conditions: Thyroid Eye Disease

Summary: to evaluate the efficacy of batoclimab 680 milligrams (mg) subcutaneous (sc) once a week (qw) for 12 weeks followed by 340 mg sc qw for 12 weeks versus placebo on proptosis responder rate at week 24.


Eligibility criteria:
inclusion criteria: * are ≥18 years of age at screening. * have a clinical diagnosis of ted associated with active, moderate to severe ted with the following at screening and visit 0: * a cas ≥ 4 in either eye, and * clinical evidence of worsened proptosis with: 1. proptosis ≥ 18 mm and/or 2. proptosis ≥ 3 mm increase from participant's baseline (prior to diagnosis of ted), as estimated by the investigator/assessor * have moderate to severe active ted, as defined by european group on graves' orbitopathy (eugogo) guidelines. * have onset of active ted within 12 months prior to screening. * have documented evidence of detectable anti-tshr-ab at screening. * are not expected to require immediate surgical intervention and are not planning corrective surgery/irradiation or medical therapy for ted during the course of the study. * are euthyroid with the baseline disease under control or have mild hypo- or hyperthyroidism. additional inclusion criteria are defined in the protocol. exclusion criteria: * have decreased best corrected visual acuity due to optic neuropathy. * have at least a 2-point decrease in cas or ≥2 mm decrease in proptosis between screening and baseline assessments in either eye. * have used any steroid (intravenous or oral) for the treatment of ted or other conditions within 4 weeks prior to screening. * have used any steroid (intravenous or oral) with a cumulative dose equivalent to ≥ 1 g of methylprednisolone for the treatment of ted. * have known autoimmune disease other than ted, that, in the opinion of the investigator, would interfere with the course and conduct of the study. * had previous orbital irradiation or surgery for ted. additional exclusion criteria are defined in the protocol.

Keywords: batoclimab thyroid eye disease imvt-1401 monoclonal antibody autoimmune disorders graves' ophthalmopathy graves' orbitopathy
the reliability of the box and block test in people after stroke

Conditions: Motor Activity

Summary: the main aim of the pilot project is to establish inter-rater reliability, internal variability and variability of results got in box and block test administered according to the new czech extended version of its manual.

new czech manual for the box and block test was made by back-translation method. it was updated and extended by new rules for unification of it´s performing. the manual include instructions for performing three trials. at least 20 adult people after stroke will be tested by this test according to this new czech manual. video of patients' performance will be obtained. the inter-rater reliability, internal variability and variability of results will be established.

Eligibility criteria:
inclusion criteria: * czech language as a mother tongue * adult (age 18 and more) * patient after stroke attending the department of rehabilitation medicine, first faculty of medicine, charles university and general university hospital in prague * able to move 25mm x 25mm block at least by 10 cm * able to complete testing with full 3 attempts * able to sit for 20 minutes exclusion criteria: * use of drugs affecting attention * vision impairment uncorrectable with glasses * severe hearing loss * inability to understand instructions * inability to complete testing * failure to sign informed consent for probation with inclusion to research and consent to the collection and processing of personal data during the study at the general university hospital in prague

Keywords: standardized test occupational therapy fine motor skills box and block test inter-rater reliability variability czech language stroke
feasibility of improving cerebral autoregulation in acute intracerebral haemorrhage

Conditions: Stroke, Acute; Hemorrhage; Cerebral Brain Hemorrhage; Blood Pressure

Summary: in the uk, 23,000 (15%) of the 150,000 people who suffer a stroke each year have bleeding in the brain, also referred to as acute intracerebral haemorrhage (ich). an autoregulation index (ari) can be assigned between 0 and 9 (0 being poor and 9 being the most efficient ca observed) to gauge how good the control over blood flow is at a given time. dynamic ca (dca) is a measure of the response of cerebral blood flow (cbf) to rapid changes in blood pressure (bp), and several key studies have shown impaired dca post-acute ich. the most recent study demonstrated that dca impairment lasts up to 12 days. this is particularly important to understand, since our preliminary work has recently shown that changes in carbon dioxide using simple breathing exercises can improve autoregulation. unfortunately, there are limited non-pharmacological management options and significant opportunities to improve patient outcome in ich. the proposed study addresses this area, by investigating whether a simple breathing exercise in survivors of ich is safe, feasible and effective in reducing brain injury by improving cerebral autoregulation.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of a haemorrhagic stroke within 48 hours of onset (for patients waking with a stroke, time of onset will be taken to be the time when the patient was last asymptomatic) * able and willing to give informed consent * male or female, aged 18 years or above * able (in the investigator's opinion) and willing to comply with all study requirements * willing to allow his or her general practitioner (gp) to be notified of participation in the study exclusion criteria: * male or female, aged under 18 years * significant previous airways disease (formal diagnosis of moderate or severe airways disease and having treatment for this respiratory condition - via inhalers or specialist input) * unable (in the investigator's opinion) or unwilling to comply with any study requirements * female participants who are pregnant, lactating or planning pregnancy during the course of the study * clinical diagnosis of stroke greater than 48 hours from onset * having had a resolved transient ischaemic attack (tia) (i.e. neurological symptoms completely resolved upon hospital presentation) * co-morbidity with anticipated life expectancy less than 3 months

Keywords: cerebral haemodynamics carbon dioxide cerebral autoregulation
discontinuation of antipsychotics and antidepressants among patients with bpsd

Conditions: Dementia

Summary: the aim of this study is to discontinue antipsychotics and antidepressants, and to study its effect on behavioural- and psychological symptoms in dementia (bpsd).

patients with dementia have cognitive deficits, but also hallucinations, delusions, agitation, aggression and apathy. these symptoms are called behavioural- and psychological symptoms in dementia (bpsd), and are difficult to treat. antipsychotic and antidepressant medication is in use, despite its lack of clinical evidence. we will discontinue antipsychotics in one group of 12 patients and antidepressants in one group of 12 patients. patients should have dementia of alzheimer- or vascular origin. they should live in nursing homes and have no other psychiatric disease for which they receive psychotropic drug. they will be registered with 7 different questionnaires at baseline and after 3, 6, 12 and 24 weeks. the study period is 24 weeks. the questionnaires are filled in by the patients and the nurses at the nursing homes. this is an open labelled study with no control group. based on the results of this study, we will design a rct study with placebo-controlled group.

Eligibility criteria:
inclusion criteria: * vascular- or alzheimer dementia * nursing homes resident for 3 months or more * given antipsychotics or antidepressants for 3 months or more * clinical dementia rating 1, 2 or 3 exclusion criteria: * dementia of other origin * psychiatric disease * life expectancy less than 3 months * acute infection last 10 days * unstable diabetes mellitus * terminal disease

Keywords: antidepressive agents neuroleptica dementia discontinuation study behavioural- and psychological symptoms in dementia
hypertension management using remote patient monitoring

Conditions: Hypertension

Summary: a longer-term follow-up of patients with remote patient monitoring ordered from the initial six pilot primary care clinics (from the prior study periods: study 1 and study 2) will be performed and compared to a cohort of patients without rpm orders, matched on clinical and demographic characteristics, from the same six pilot primary care clinics, to serve as contemporary controls.


Eligibility criteria:
inclusion criteria cases patients from any of 6 primary care sites that participated in remote monitoring pilots who had remote patient monitoring (rpm) ordered by a primary care clinician between november 18, 2018 and august 14, 2021 - exclusion criteria: * patients whose rpm ordered by non-primary care clinics matching cohort inclusion * patients from the six pilot clinics and * meet the matching criteria exclusion * patients with any rpm order between between november 18, 2018 and august 14, 2021
acupuncture for dry eye

Conditions: Dry Eye

Summary: the purpose of this study is to assess whether acupuncture is more effective than artificial tear drop in the treatment of dry eye.

dry eye is one of the common diseases in ophthalmology. it affects not only patients' daily activities such as reading, carrying out professional work, using the computer, watching television, and driving, but also bodily health conditions such as bodily pain, discomfort and lower energy and vitality. currently, artificial tears are easily subscribed or used in the shape of otc drugs. however, preservatives in artificial tears may exacerbate ocular surface inflammation and the safety of anti-inflammatory treatment is not well established. acupuncture, one of the most popular cam interventions, showed some favourable effects over artificial tears for dry eye in several randomised controlled trials (rcts). the evidence obtained from these trials is quite limited because all of these rcts were conducted under high risk of biases. therefore, well-designed rcts are needed to establish the efficacy of acupuncture for dry eye. in a clinical trial, cost-effectiveness and qualitative researches can be carried out parallely. through this kind of mixed method approaches, various compartments, consisting acupuncture treatment effects are able to be revealed totally. in this context, the investigators designed a multi-center randomized controlled trial, comparing acupuncture treatment and artificial tear drop with immunoassay for the change of tear cytokine concentration, cost effectiveness study and qualitative research in a mixed method approach.

Eligibility criteria:
inclusion criteria: * patients who have had dry eye syndromes in single eye or in both eyes (icd-10 : h04.1). he or she must have both of the conditions below: 1. patients who have dry eye symptoms such as itching, ocular foreign body sensation, ocular burning, ocular pain, ocular dryness, blurred vision, sensation of photophobia, ocular redness, sensation of tearing 2. patients whose tear film break-up time is below 10 seconds and schirmer i test results is below 10mm/5sec. exclusion criteria: * patients who have defects of the eyelid or eyelashes * acute infection of the eyelid, eyeball or eye accessories * stevens-johnson syndrome * vitamin a deficiency * eye or accessory defects due to external injuries * a past history of surgical operation related to the eye in last three months * punctual occlusion * current usage of contact lenses * sequelae of facial palsy, * current usage of anti-inflammatory eye drops in the last two weeks * pregnancy * using history of traditional medicinal treatment such as acupuncture, moxibustion and herbal medicine in the last one month

Keywords: acupuncture dry eye artificial tear drop mixed method approach qualitative study cost effectiveness analysis tear cytokine analysis
evaluating a structural and behavioral hiv risk reduction program for black men

Conditions: HIV

Summary: the purpose of this study is to evaluate the effectiveness of the making employment needs (men) count intervention, an hiv intervention and prevention program for heterosexual black men. the men count model integrates hiv risk reduction and gender-equity counseling with housing and employment case management via multiple one-on-one sessions delivered by a peer case manager over 60-90 day period. men count was developed and pilot tested using a community-based participatory research (cbpr) approach via funding from a national institutes of health (nih) r21, in boston, massachusetts. a more larger scale, two-armed quasi-experimental controlled trial design will be used to test men count among black men recruited/enrolled from an std clinic and other community-recruitment methods in washington, dc. study participants (n=504) will be black men reporting heterosexual risk for hiv \[unprotected sex with a woman and 2+ female sex partners in the past 6 months\] and either current unemployment or homeless in the past 6 months. to evaluate the effectiveness of men count, a two-armed quasi-experimental design will be conducted in which participants will receive either men count or an attention comparison program similar to men count in structure. we will assess program impact on reduction in number of unprotected sex episodes and incident cases of sti (chlamydia, gonorrhea, syphilis) via survey and sti testing, respectively, at baseline and 6 and 12 month follow-ups. additionally, quality assurance and process evaluation efforts will be conducted to ensure high quality program adherence and delivery, as well as to support program replication should the model prove effective.


Eligibility criteria:
inclusion criteria: black men aged 18 and older, reporting heterosexual risk for hiv \[unprotected sex with a woman and 2+ female sex partners in the past 6 months\] and either current unemployment or homeless in the past 6 months. exclusion criteria: planned to leave washington d.c., maryland, or virginia in the next 6 months, were cognitively impaired (based on folstein mini-mental exam at recruitment or baseline testing), and/or had self-reported health status that prohibited them from participating in the program

Keywords: hiv prevention african american men evaluation study
cognitive-motor intervention using virtual reality for middle-aged individuals at high dementia risk

Conditions: Alzheimer's Disease (AD)

Summary: the primary objective of this program is to apply a virtual reality (vr) cognitive-motor intervention (compared to active and passive control groups) to delay or slow cognitive decline of middle-aged adults who have a family history of alzheimer's disease (ad) and thus are at particularly high risk of developing the disease.


Eligibility criteria:
inclusion criteria: * the participants of the study must have at least one parent with alzheimer's disease. * fluency in hebrew, in order to understand the instructions of the cognitive tests. * availability of an informant for the participant. exclusion criteria: * severe neurological or psychological conditions that may affect cognitive performance. * substantial orthopedic limitations which prevent the use of treadmill. * unstable medical condition such as an active cancer. * incapability of adherence to the training program. * the participant is undergoing a treatment that may interfere with the study program.

Keywords: alzheimer's disease virtual reality cognitive training
long-term follow-up study of advm-043

Conditions: Alpha-1 Antitrypsin Deficiency

Summary: advm-043-03 is a long-term follow-up (ltfu) study of subjects who participated in the advm-043-01 (nct02168686) multi-center gene therapy clinical study (advance) that evaluated advm-043 for the treatment of alpha-1 antitrypsin (a1at) deficiency.

advm-043-03 was a multi-center, observational study without administration of the advm-043 investigational product. subjects who participated in the advance study (advm-043-01; nct02168686) were enrolled into this ltfu study for continued safety monitoring for a 2-year period.

Eligibility criteria:
key inclusion criteria: * the subject has a1at deficiency and has previously received advm-043 gene therapy key exclusion criteria: * the subject is unwilling or unable to participate in all required study evaluations in the long-term follow-up protocol * the subject is participating in another investigational treatment protocol * the subject is unable to understand the purpose and risks of the study or cannot provide a signed and dated informed consent form (icf)

Keywords: alpha-1 antitrypsin deficiency alpha1-antitrypsin deficiency alpha 1-antitrypsin deficiency alpha1at a1at advm-043 aavrh.10halpha1at aavrh.10ha1at gene transfer vector gene therapy lung disease emphysema copd advance study long term follow up
pet/mri in the diagnosis of pediatric chronic pain

Conditions: Chronic Pain; Pediatric Disorder; Neuropathic Pain; Nociceptive Pain

Summary: \[18f\]ftc-146 is a sigma-1 receptor detector and is an experimental radiotracer. several studies have implicated involvement of sigma-1 receptors in generation and perpetuation of chronic pain conditions, while others are investigating anti sigma-1 receptor drugs for treatment of chronic pain. using \[18f\]-ftc-146 and pet/mri, we hope to learn what is the best approach to identify the source of pain generation and characterize the disease in pediatric patients with chronic pain.

it is estimated that 20% to 35% of children and adolescents worldwide are affected by chronic pain. as a result of chronic pain, children may miss school, withdraw from social activities, and develop internalizing behaviors. therefore, accurately identifying the cause of a child's pain is important for both proper treatment of the pain and to prevent problems secondary to the chronic pain. evidence in the literature points strongly toward an involvement of the sigma-1 receptor in neurogenic inflammation, which is known to be an important pathophysiological mechanism for maintenance and perpetuation of chronic neuropathic pain. the investigators hope to image and identify activated pain pathways in pediatric pain paitents using a radiolabeled biomarker for increased s1r expression. by localizing and quantifying areas of increased s1r expression to sites of augmented nociceptive activity using hybrid molecular/anatomic imaging techniques, we will objectively identify sites of neurogenic inflammatory activity and pain generation. the ability to image the changes associated with chronic pain generating pathologies provides us with a tool to identify and measure the intensity of the pathology. imaging s1r expression in chronic pain states in pediatric patients would be both novel in its application and extremely powerful in better characterizing pediatric pain.

Eligibility criteria:
inclusion criteria: * 11-18 years old. * chronic pain (nociceptive, neuropathic or mixed pain) lasting at least 2 months. * pain level of at least 4/10 on a 0-10 comparative pain scale (reported at time of screening). * covid vaccination status: vaccinated or unvaccinated subjects who received a negative test result from the covid test within 72 hours of the scan. exclusion criteria: * mri incompatible * pregnant or nursing * non-english speaker * claustrophobic

Keywords: pet/mri pediatric chronic pain