Kornimate/medical-research-clean huggingface dataset:
global postural re-education program on neck pain in breast feeding females.

Conditions: Neck Pain; Disability Physical; Breast Feeding

Summary: the significance of this study is that it will add to the growing body of knowledge that if these techniques yield outcomes in treatment of neck pain in breast feeding mothers. this study will add the beneficial effects to treat the neck pain in breast feeding females.

nonspecific neck pain is an increasingly frequent musculoskeletal condition affecting 22% to 70% of the population that is more prevalent in women than in men. some patients will not experience complete resolution of pain and disability which can become a more complex chronic pain syndrome.(2) when symptoms persist for more than 12 weeks, the condition acquires the value of chronicity and is denominated chronic nonspecific neck pain. this is associated with high costs for public health, and is becoming a socio-health problem. the mechanisms underlying recurrence or persistence of neck pain may be associated with biomechanical, functional, proprioceptive, and postural changes. however, the multidimensional nature of neck pain can involve not only the sensory-motor component, but also psychosocial components, such as anxiety, depression, and fear and catastrophic thoughts in response to pain (kinesiophobia and pain catastrophizing). in 2018, a study is conducted on the effect of global postural reeducation in patients with chronic nonspecific neck pain and their study suggested that global postural reeducation shows promising results for the improvement of neck pain and disability in patients with chronic neck pain. in 2016, a randomized controlled trial is conducted on effectiveness of global postural re-education in patients with chronic nonspecific neck pain the result of the study showed that global postural reeducation , when provided in the absence of other intervention, can significantly decrease pain pain intensity , disability and increases cervical range of motion. in 2015, a research is conducted to find out the effects in short and long term of global postural reeducation (gpr) on chronic low back pain the result showed that global postural reeducation is effective in the treatment of low back pain and function this study, suggests that postural reeducation was highly effective in managing pain and function due to low back. although quite a number of researches have been done regarding more effective treatment of neck pain, there are actually no research in effect of postural re-education is seen in breast feeding females.

Eligibility criteria:
inclusion criteria: * age 25-35 years * mothers who have pain score of 4 in nprs * mothers who breast feed their babies * post-partum period exclusion criteria: * neck pain due to any other comorbidity e.g. previous history of trauma or fracture, disc prolapse, facet joint stenosis * previously kyhoscoliotic mothers * females who have c-section
edaravone in the treatment of optic neuritis

Conditions: Optic Neuritis

Summary: edaravone has demonstrated a beneficial effect in promoting remyelination and protecting axons in animals with nmosd. the researchers posit that edaravone may enhance visual outcomes in patients with aquaporin-4 antibody-positive optic neuritis.


Eligibility criteria:
inclusion criteria: 1. chinese patients aged ≥18 with anti-aquaporin-4 antibody-positive optic neuritis 2. patients with a first episode of optic neuritis in either eye 3. first symptoms of optic neuritis ≤30 days prior to the first administration of edaravone exclusion criteria: 1. myopia over 6 diopters 2. refractive media opacity affecting assessment of retinal layers and/or visual acuity
early mobilization for critical patients on invasive mechanical ventilation in the intensive care unit

Conditions: Critical Illness

Summary: a single blind randomized controlled trial (the move icu study) will be conducted to evaluate the effects on critical patients on invasive mechanical ventilation of early mobilization with a cycle ergometer.

a single blind randomized controlled trial (the move icu study) will be conducted to evaluate the effects on critical patients on invasive mechanical ventilation of early mobilization with a cycle ergometer. patients (age \> 18 years) will be recruited for this study from among those admitted to the intensive care department at the hospital de clínicas de porto alegre. eligible patients will have been on invasive mechanical ventilation for at least 24 to 48 hours, will have spent maximum of 1 week in hospital and will not exhibit any characteristics restricting lower extremity mobility. these subjects will be randomized to receive either conventional physiotherapy or conventional physiotherapy with an additional cycle ergometer intervention. the intervention will be administered passively for 20 minutes, at 20 revolutions per minute, once per day, throughout the time the patients remain on invasive mechanical ventilation.

Eligibility criteria:
inclusion criteria: * patients of both sexes aged \>= 18 years will be recruited from among those admitted to the hospital de clínicas de porto alegre intensive care unit and put on invasive mechanical ventilation invasive mechanical ventilation for at least 24 to 48 hours after transfer from the emergency department or wards, no more than 1 week after admission exclusion criteria: * neuromuscular diseases causing motor deficits, such as strokes, multiple sclerosis, amyotrophic lateral sclerosis, myasthenia gravis and guillain barré syndrome. * patients will also be excluded in the event of the following: extubation less than 48 hours after enrollment on the study * haemodynamic instability (noradrenaline \> 0.5 mc/kg/min for arterial blood pressure \> 60 mmhg) * complications during the protocol such as pneumothorax, deep vein thrombosis or pulmonary embolism * shilley catheter in the femoral vein * reintubation * delayed weaning (3 failed spontaneous ventilation tests) * body mass index \> 35 kg/m2 * emergence of eschar in the calcaneus area during the protocol.
a prospective, observational study of patients with cervical dystonia (dystonie) treated with onabotulinumtoxina

Conditions: Torticollis

Summary: this is an observational study to assess health-related quality of life in patients with cervical dystonia (dystonie) treated with onabotulinumtoxina per routine clinical practice.


Eligibility criteria:
inclusion criteria: * diagnosis of cervical dystonia (dystonie) and able to receive botulinum toxin type a as deemed medically necessary by the physician exclusion criteria: * participation in a clinical trial for any botulinum toxin indication * planning elective surgery during the observational study period * treatment with any botulinum toxin product for cervical dystonia (dystonie) * treatment with any botulinum toxin product for a non-cervical dystonia (dystonie) condition within 2 months of study start
post-marketing safety study to assess the risk of spontaneous abortions in women exposed to cervarix residing in uk

Conditions: Infections, Papillomavirus

Summary: this study will assess the risk of spontaneous abortion during weeks 1-23 and weeks 1-19 of gestation, respectively, and other pregnancy outcomes, in an exposed cohort, i.e. women with last menstrual period (lmp) between 30 days before and 45 days after, or 30 days before and 90 days after any dose of cervarix, when compared to a non-exposed cohort, i.e. women with lmp between 120 days and 18 months after the last cervarix dose. the data collected in the clinical practice research datalink general practitioner online database (cprd gold) in the uk, will be analysed in this study.

convenience sampling will be used in this study. it is planned to include all eligible pregnant women (included in cprd gold and who fulfil to the inclusion/exclusion criteria) in each of the two cohorts.

Eligibility criteria:
inclusion criteria: for the exposed cohort: all subjects must satisfy all of the following criteria at entry into the exposed cohort: * full date of first day of lmp available in the database or calculated from estimated date of delivery (edd). * female, aged between, and including, 15 and 25 years of age at lmp. * recorded in the cprd gold for at least 12 months at lmp. * first day of lmp available in the database or calculated from edd between september 1st 2008 and june 30th 2011. * at least one dose of cervarix received between september 1st 2008 and june 30th 2011. * full date of cervarix vaccination(s) available. * first day of lmp available in the database or calculated from edd between 30 days before and 90 days after any dose of cervarix. * subject defined as acceptable in cprd gold. for the non-exposed cohort: all subjects must satisfy all of the following criteria at entry into the non-exposed cohort: * full date of first day of lmp available in the database or calculated from edd. * female, aged between, and including, 15 and 25 years of age at lmp. * recorded in the cprd gold since at least 12 months at lmp. * first day of lmp available in the database or calculated from edd between september 1st 2008 and june 30th 2011. * at least one dose of cervarix received between september 1st 2008 and june 30th 2011. * full date of cervarix vaccination(s) available. * first day of lmp available in the database or calculated from edd between 120 days and 18 months after the last dose of cervarix. * subject defined as acceptable in cprd gold. exclusion criteria: for the exposed cohort: • female with the first day lmp between 30 days before and 90 days after at least one dose of unspecified human papillomavirus vaccine and/or gardasil. for the non-exposed cohort: * female with the first day lmp between 30 days before and 90 days after at least one dose of unspecified human papillomavirus vaccine and/or gardasil. * female included for a previous pregnancy in the exposed cohort.

Keywords: cervarix spontaneous abortion vaccine human papillomavirus
ocular point of care ultrasound (pocus) to detect optic disc swelling in comparison to ophthalmologic examination

Conditions: Papilledema Associated With Increased Intracranial Pressure

Summary: pediatric emergency department (ped) physicians frequently encounter children with symptoms that warrant evaluation of the optic disc for suspected increased intracranial pressure (icp) such as headache, blurred vision, recurrent vomiting etc. fundoscopic examination, by the ped physician, is considered an essential modality for assessment of the optic disc and the diagnosis of papilledema. obtaining good visualization of the optic disc requires patient compliance, the ability to open the eyelids, the absence of opacities in the ocular media and a sufficiently large pupillary aperture. hence, different levels of ped physician training, lack of cooperation, significant ocular or periorbital trauma, contraindications to mydriasis and severe photophobia may hinder direct fundoscopic evaluation. in the investigators' ped, children requiring fundoscopy are sent to a formal ophthalmologic examination. the investigators aim to evaluate the yield of optic disc height as measured with ocular point of care ultrasound to detect optic disc swelling in comparison to ophthalmologic examination as the gold standard.


Eligibility criteria:
inclusion criteria: * consecutive patients from the ped, * aged 0-18 years, * who require funduscopic examination and referred to ophthalmologic evaluation. exclusion criteria: * direct trauma to the eye with suspicion of ruptured globe or laceration of the eyelid, * history of glaucoma.
intracorporeal vs extracorporeal urinary diversion after robot assisted radical cystectomy

Conditions: Bladder Cancer

Summary: intracorporeal urinary diversion (icd) provides superior postoperative outcomes compared to extracorporeal urinary diversion (ecd). the investigators' hypothesis that icd may provide clinical benefit is based on principles of less bowel and ureteral handling, superior operating room workflow, less exposure to the external environment, and optimal visualization with icd while utilizing a smaller incision compared to ecd. icd should have less bowel-related complications, lower pain scores allowing patients to be discharged from the hospital sooner and regain functional independence more quickly.


Eligibility criteria:
inclusion criteria: * biopsy-proven urothelial cancer being considered for rarc. * clinical stage t1-t4, n0-1, m0 or refractory carcinoma in situ. * subject must be already scheduled to have a rarc at the discretion of the surgeon and with the patient's agreement. exclusion criteria: * inability to give informed consent * prior major abdominal and pelvic open surgical procedures that would preclude a safe robotic approach, as determined by the treating surgeon. * at the discretion of the treating surgeon, any pre-existing condition such as severe chronic obstructive pulmonary disease that precludes a safe initiation or maintenance of pneumoperitoneum over a prolonged period of time and during surgery. * age \ 99 years.
the effects of epa/dha supplementation on cognitive control in children with adhd

Conditions: Attention Deficit Hyperactivity Disorder; Healthy

Summary: forty children with and 40 children without attention deficit hyperactivity disorder (adhd) receive docosahexaenoic acid (dha) and eicosapentaenoic acid (epa) or placebo via a dietary intervention. cognitive control functions are measured with functional magnetic resonance imaging (mri) before and after the intervention. behavioural change is monitored with behavioural scales.


Eligibility criteria:
inclusion criteria: inclusion criteria for subjects with adhd 1. 8-12 year old boys 2. diagnostic and statistical manual 4th edition (dsm-iv (apa, 1994)) diagnosis of adhd, according to diagnostic interview schedule for children (disc) 3. scores in the clinical range on the child behaviour checklist (cbcl) and teacher rating form(trf) 4. ability to speak and comprehend dutch. 5. used to daily consumption of margarine inclusion criteria for controls 1. 8-12 year old boys 2. no dsm-iv (apa, 1994) diagnosis, according to disc interview 3. no scores in the clinical range on the child behaviour checklist (cbcl) and teacher rating form (trf) 4. ability to speak and comprehend dutch. 5 used to daily consumption of margarine exclusion criteria: 1. mental retardation (iq \< 70) 2. major illness of the cardiovascular, the endocrine, the pulmonary or the gastrointestinal system 3. presence of metal objects in or around the body (pacemaker, dental braces) 4. history of or present neurological disorder 5. regular use of n-3 or n-6 fatty acid dietary supplements, products fortified with epa or dha, a regular diet high in fatty fish (= 1 serving per week) or participation in intervention studies or (school-) health programs in the four months prior to study participation.

Keywords: attention cognitive control adhd healthy epa eicosapentaenoic acid dha docosahexaenoic acid pufa omega-3
vasopressin for septic shock pragmatic trial

Conditions: Septic Shock

Summary: life-threatening low blood pressure due to a serious infection is called "septic shock." septic shock is treated with vasopressors, medications that raise blood pressure. sometimes first-line vasopressors are inadequate, prompting addition of a second-line vasopressor called vasopressin. however, the threshold at which to start vasopressin remains unclear. this pragmatic, cluster-randomized, cluster-crossover trial will evaluate two different strategies for septic shock treatment commonly used in current practice, comparing a lower versus a higher threshold for adding vasopressin to first-line vasopressors.


Eligibility criteria:
inclusion criteria: 1. age ≥18 years 2. admitted to a study hospital emergency department (ed) or inpatient care unit 3. administration of vasopressor(s) for septic shock exclusion criteria: none

Keywords: vasopressin vasopressors treatment strategy
pexiganan versus placebo control for the treatment of mild infections of diabetic foot ulcers

Conditions: Diabetic Foot Infection

Summary: the purpose of this study is to establish the clinical superiority and the safety of topical pexiganan cream 0.8% plus standard local wound care as compared to placebo cream plus standard local wound care, in the treatment of mildly infected diabetic foot ulcers.


Eligibility criteria:
inclusion criteria: 1. diabetes mellitus. 2. male or female at least 18 years old. 3. subject must agree to adhere to all protocol procedures and return for all scheduled visits, and must be willing and able to provide written informed consent. 4. subject is to be treated on an outpatient basis. 5. full thickness ulcer or a partial thickness ulcer on the foot distal to the malleoli with a surface area ≥ 1 cm2 after the wound has undergone appropriate debridement. 6. localized mild infection of the ulcer. 7. the diagnosis of mild infection must be confirmed immediately following debridement at baseline. 8. subject must have plain radiographs taken within 2 days prior to entry showing no evidence of bony abnormalities consistent with osteomyelitis, or gas compatible with tissue crepitus, in the affected foot. exclusion criteria: 1. idsa-defined moderate infection, including cellulitis extending \> 2 cm; lymphangitis; spread beneath the fascia; deep tissue abscess; gangrene; muscle, joint, or bone involvement. 2. idsa-defined severe infection, including systemic toxicity or metabolic instability. 3. infected diabetic foot ulcer that is associated with local wound complications such as prosthetic materials or protruding surgical hardware. 4. \> 1 infected foot ulcer. 5. subject is currently receiving topical antimicrobial treatment for a localized infection of the study ulcer and whose infection is improving in response to treatment. 6. subject has received a systemic antibiotic within 48 hours prior to screening. 7. concurrent or expected to require systemic antimicrobials during the study period for any infection, including diabetic foot ulcer. 8. bone or joint involvement is suspected based on clinical examination or plain x-ray. 9. clinically significant peripheral arterial disease requiring vascular intervention. 10. subject is expected to be unable to care for the ulcer or return for all scheduled visits because of hospitalization, vacation, disability, etc. during the study period, or is unable to safely monitor the infection status at home.

Keywords: diabetic foot ulcer infection
enteric nervous system in parkinson's disease

Conditions: Parkinson's Disease

Summary: the "core" of the neuronal lesions in parkinson's disease (pd) is the progressive degeneration of dopamine neurons in the substantia nigra. a significant loss of dopamine neurons and the presence of lewy bodies (a pathological hallmark in pd) in enteric neurons have also been reported in that disease. these lesions may explain the frequent gastro-intestinal dysfunction observed in pd patients. alterations of other neuronal populations within the enteric nervous system (ens) as well as the mechanisms responsible for these lesions (type of cell death, alteration of neuromediators gene expression) remain to be identified. the aim of the study is to demonstrate that alterations of the human ens in pd can be evidenced by bowel biopsies and to determine whether they are correlated to the severity of motor disability and to gastrointestinal dysfunction.


Eligibility criteria:
inclusion criteria: * parkinson's disease patients at 3 different stages: * early pd (before l-dopa-induced complication); * patients with l-dopa-induced complication; * patients with balance impairment or cognitive decline. * controls: patient at risk of colic cancer for whom a coloscopy is required.

Keywords: parkinson's disease enteric nervous system
pulmonary determinants of cardiorespiratory fitness in fontan patients

Conditions: Fontan Procedure; Congenital Heart Disease

Summary: this study will examine and record the patient's medical information and medical records (patient files, computer records, etc.). physical examination, echocardiographic, electrocardiographic, laboratory, radiological, etc. evaluations are made during the routine controls of the patients. within the scope of this study, no attempt will be made on the patients, no additional tests will be performed, or treatment changes will not be made in the patients because they are included in this study. after these records, kpet will be performed by a specialist doctor and physiotherapist for the patients who are directed to the faculty of physical therapy and rehabilitation cardiopulmonary rehabilitation unit. pulmonary function tests and respiratory muscle strength measurements will be performed on patients who have adequate rest after cpet.


Eligibility criteria:
fontan group inclusion criteria: * be between 8-55 years old * having undergone a fontan operation * clinical stability of the patients (preserved ventricular function) * no change in ongoing drug therapy that adversely affects clinical stability * at least 1 year after the operation fontan group exclusion criteria: * neurological and/or genetic musculoskeletal disease * having orthopedic and cognitive problems that prevent testing * the patient's and/or family's unwillingness to participate in the study control group inclusion criteria: * not have cardiovascular, neurological, and/or genetic musculoskeletal disease * not having orthopedic and cognitive problems that prevent testing * the patient's and/or family's willingness to participate in the study
effects of the breathe technologies ventilation system in subjects with chronic obstructive pulmonary disease

Conditions: Chronic Obstructive Pulmonary Disease

Summary: pilot study in 15 stable male subjects with severe-to-very severe chronic obstructive pulmonary disease (copd) to evaluate the effects of short term use of the breathe technologies noninvasive open ventilation (niov) system on respiratory mechanics during constant work rate exercise in subjects with severe copd.

study was a randomized double-blinded crossover design in which subjects completed a series of exercises at a constant work rate while using 1) test noninvasive ventilation (niov) system powered by compressed air, 2) test niov system powered by 100% oxygen, 3) nasal cannula oxygen, 4) nothing (control). subjects were assessed during constant work rate exercise as reflected by exercise duration, isotime oxygenation (spo2), and isotime dyspnea score (borg). exercise sessions took place over 4 visits with each visit lasting approximately 5 hours.

Eligibility criteria:
inclusion criteria: * adult males, ≥ 40 years of age * diagnosis of severe copd (gold stage iii or iv) defined as having a fev1 \< 50% of predicted and an fev1/fvc ratio \< 70% of predicted * ventilatory limitation to exercise, documented by a ve/mvv \> 0.85 * spo2 between 80% and 88% during incremental exercise testing on room air * willingness and ability (after training) to exercise on a cycle ergometer * willingness and ability to perform all other study related procedures and tasks * ability to be properly fitted with the breathe nasal mask * ability to tolerate and be appropriately titrated on the breathe ventilator (see appendix e) * ability to be properly fitted with an exercise mask * fluency in written and spoken english * provision of written informed consent exclusion criteria: * history of acute exacerbation of copd within 30 days of screening * history of serious epistaxis within 14 days of screening * requirement of \> 5 lpm nasal o2 to maintain an spo2 \> 90% while at rest * history of pneumothorax secondary to lung bullae * history of intolerance to supplemental oxygen * musculoskeletal or other non-pulmonary impairment that limits exercise tolerance * inability to achieve an optimal cwr level (4-7 minutes) during study visit 1r * current participation in another interventional study or participation within 14 days of screening * presence of any condition or abnormality that in the opinion of the principal investigator may compromise the subject's safety or the quality of the study data

Keywords: copd ventilator constant work rate