Kornimate/medical-research-clean huggingface dataset:
stress recovery program forest+ for healthcare workers

Conditions: Stress, Psychological

Summary: the aim of the study is to assess the efficacy of an online stress recovery intervention for healthcare workers receiving therapist-assisted or on-demand support.

the intervention will be delivered as an online stress recovery program for healthcare workers, consisting of six modules. modules include an introduction, psychological detachment, distancing, mastery, control, and keeping the change alive. these modules have been chosen after considering themes that could be most useful for healthcare workers under high stress. each module consists of a psychoeducational and an exercise component. during the program, a therapist provides individual feedback on the exercises completed and can also be available on request. the effect of the intervention will be compared with a control group that will use the program with support on-demand. the intervention will be delivered in lithuanian.

Eligibility criteria:
inclusion criteria: * licensed healthcare professionals currently working under license; * at least 18 years old; * comprehending lithuanian language; * access to internet. exclusion criteria: * acute psychiatric crisis; * high suicide risk; * interpersonal violence.
nevanac 3-month safety study with qid dosing

Conditions: Cataract

Summary: the purpose of this study is to determine the safety of nevanac 0.1% compared to acular ls 0.4% and vehicle in patients treated before cataract surgery and for approximately 90 days following surgery.


Eligibility criteria:
inclusion criteria: * patients of any race or sex ages 10 years or older undergoing cataract extraction with planned implantation of a posterior chamber intraocular lens. * other protocol-defined inclusion criteria may apply. exclusion criteria: * under 10 * other protocol-defined exclusion criteria may apply
exercise and diet in type 2 diabetic women

Conditions: Insulin Sensitivity; Type 2 Diabetes

Summary: the purpose of this study was to evaluate the effects of 12 weeks' increased daily physical activity versus diet restriction on regional fat distribution, insulin sensitivity and adipokines including retinol binding protein-4 (rbp-4), leptin, adiponectin, and a new marker, adiponectin to leptin ratio (al ratio), in type 2 diabetic women.


Eligibility criteria:
inclusion criteria: * type 2 diabetic patient * bmi\>23kg/m2 * female exclusion criteria: * the patients with co-morbidity such as heart failure, chronic kidney disease or liver cirrhosis

Keywords: intra-abdominal fat adipokines exercise diet therapy
abnormally high parathyroid hormone levels worsens outcomes in vitamin d depleted critical care patients

Conditions: Vitamin D Deficiency; Hyperparathyroidism; Critically Ill Patients Admitted in ICU

Summary: this study aims to investigate the impacts of abnormally elevated pth levels on clinical outcomes among critically ill patients with vitamin d depletion.

this study is a secondary analysis of data from a previous multicentre, prospective, observational cohort study (rec no: 201805087rinb) examining vitamin d deficiency prevalence and outcomes in critical care. from the previously enrolled 651 critically ill patients admitted to medical and surgical intensive care units (icus), those enrolled within 48 hours of admission are analyzed. vitamin d depletion is defined as a serum 25-hydroxyvitamin d (25(oh)d) level \ 68.3 pg/ml). the primary endpoints include the rate of survival to day 28 and the rate of survival to hospital discharge. secondary endpoints include the length of icu stay at day 28 and day 90, acute physiology and chronic health evaluation (apache) ii score, sequential organ failure assessment (sofa) score, and blood clinical laboratory variables.

Eligibility criteria:
inclusion criteria: 1. critically ill patients within 48 hours of icu admission exclusion criteria: 1. less than 20 years old 2. severe malnutrition (bmi\<18kg/m2) 3. severe anemia (hemoglobin concentration \<7g/dl) 4. receiving high-dose vitamin d treatment (\> 3000 iu/day) within four weeks 5. have been admitted to the icu within three months 6. suffering from diseases that affect vitamin d concentration, calcium metabolism or bone metabolism (for example: parathyroid disease, rickets, chirtosis, and severe cirrhosis \[child c\]) 7. patients and family members who do not speak the native language

Keywords: parathyroid hormone vitamin d depletion 25(oh)d critical illness mortality
exercise study for breast cancer survivors

Conditions: Breast Cancer

Summary: this study evaluates the link between muscle health and immune health in breast cancer survivors. regular exercise is known to improve overall survival in cancer patients but the mechanism is not known. in this study the investigators will evaluate if improving muscle mass and strength via exercise improves the immune system's ability to fight cancer. this is a one armed study where in 30 breast cancer survivors will be recruited to a 4 month exercise intervention. increase in muscle mass and strength will be correlated with immune cell frequency and function.

breast cancer survivors with stronger and larger muscles have better overall survival and lower recurrence than women with weaker and smaller muscles. however, the mechanism for this association is currently unknown. a recent study from the investigators has shown that there is an association between the frequency of immune cell types that kill cancer and higher muscle mass and strength, with higher muscle mass and strength correlating with a higher frequency of cancer killing, effector memory, t cells. the investigators thus propose that increasing muscle mass and strength can improve overall survival and reduce recurrence by increasing the number of cancer killing immune t cells. to test this hypothesis, the investigators will recruit 30 breast cancer survivors to an exercise program designed to increase their muscle mass and strength. the program will be optimized to each participant's level of fitness and strength and will be designed by experts in the field. personal trainers will teach the participants how to exercise and use muscle resistance training equipment using the correct technique and will monitor progress to avoid injuries and to maximize training benefits. the investigators will collect blood (to study immune cell subsets) and measure muscle strength and body composition (to measure muscle mass) for participants before and after the study. the duration of the exercise training protocol is 4 months and participants will be asked to exercise 4 days a week; 2 days at the gym and 2 days at home.

Eligibility criteria:
inclusion criteria: * women * post menopausal * stage i - iii breast cancer * breast cancer the only cancer * can exercise for 16 weeks; 2 days a week at the gym and 2 days of the week at home * live in the san diego area exclusion criteria: * exercise regularly in the gym. * are on chemotherapy or radiation therapy or have been in the past month * will be on chemotherapy or radiation therapy in the next 6 months * have a condition that will prevent them from exercising in the gym

Keywords: exercise resistance exercise t cells immune system
effects of spinal manipulation in patients with nonspecific low back pain

Conditions: Back Pain; Lumbar Pain Syndrome; Back Pain, Low

Summary: introduction: nonspecific low back pain is the most common cause of visits to medical personnel and is the largest cause of absenteeism in the world. (1), nonspecific low back pain accounts for 85% of low back pain, notably affecting quality of life and working life (2), there is a 50-70% probability that a person will have low back pain during their life ( 3), lumbago produces 300,000 years lived with disability (adl), being the first burden of disease in chile, surpassing hypertensive heart disease and depression (4). there are many therapeutic approaches to the management of nonspecific low back pain, including high-speed, low-amplitude spinal manipulations (5). this technique consists of applying a short and rapid force at the level of the joint that is restricted, in order to restore normal joint mobility. the physiological effects of manipulations are not sufficiently studied, but some authors (6) (7) suggest that the nervous system is the mediator of the effects of spinal manipulation. among non-pharmacological interventions, numerous clinical guidelines recommend the use of therapeutic exercise for low back pain (8), including a wide variety of types of recommended exercises, the most traditionally recommended being aerobic exercises, exercises that involve stretching postures of the back. vertebral musculature, strengthening and strength exercises (9) and central stabilization exercises (10). recently, the effects of inspiratory muscle and diaphragm training exercises in patients with low back pain are being investigated (11). the application of an elastic bandage (12) in the lumbar area generates a proprioceptive signal through the skin, producing analgesia and a feeling of support in the area. objectives: to compare the effects of different therapeutic approaches in combination with spinal manipulation. design and method: single-blind randomized clinical trial results: significant differences are expected before and after treatment and differences between groups. conclusion: the aims of this study is to demonstrate that high speed and low amplitude spinal manipulation plus other conservative treatment is a valid therapeutic strategy for the management of nonspecific low back pain


Eligibility criteria:
inclusion criteria: * older than 18 years * with nonspecific low back pain exclusion criteria: * chronic low back pain (more than 3 months) * spinal surgeries * red flags for spinal manipulation (osteoporosis, bone metastasis, etc)
comparison study of transarterial chemoembolization and percutaneous ethanol injection for multiple, small hccs

Conditions: Hepatocellular Carcinoma

Summary: the purpose of this study is to choose the preferred treatment modality for multiple, small hepatocellular carcinomas.

to compare the below things between peit group and tace group 1. survival 1. 5 year overall survival rate 2. disease free survival rate 2. recurrence a. recurrence rate

Eligibility criteria:
inclusion criteria: * the evidences of hbv(+) \&/or hcv(+) infection or liver cirrhosis * two to three tumor nodules with child-pugh classification a or single to three tumor nodules with child-pugh classification b * the maximal, longest diameter of tumor mass measured by ct finding should be less than 2 cm. * 1) only for newly detected hccs which were not treated before or 2) if treated before, it should be noted that there is no evidence of recurrence within the latest 6 months and, and also it should be remotely recurred more than 2cm apart from primary lesion. * it should be compatible with the typical findings of hccs radiologically(md ct or dynamic mri) exclusion criteria: * in case of hepatic vein or portal vein invasion radiologically(ct or mri)

Keywords: hcc, tace, peit
evaluation of safety and effectiveness of fostamatinib compared to placebo in patients in asia with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: the purpose of the study is to evaluate the effectiveness of four dosing regimens of fostamatinib compared to placebo, in patients with rheumatoid arthritis (ra) who are taking methotrexate but not responding. the study will last for 12 weeks.

(oskira-asia-1): a multi-centre, randomised, double-blind, placebo-controlled, parallel group dose ranging study in asia evaluating efficacy and safety of fostamatinib in patients with active rheumatoid arthritis who are inadequate responders to methotrexate therapy

Eligibility criteria:
inclusion criteria: * male or female aged 18 and over * active rheumatoid arthritis (ra) diagnosed after the age of 16 * 6 or more swollen joints and 6 or more tender/painful joints from certain joints in the hands, wrists, arms and knees * at least one of: positive result for rheumatoid factor test, either in the past or currently (blood test); x-ray showing bone erosion within the last 12 months; presence of certain antibodies in the blood (blood test) * currently taking methotrexate for at least 4 months (and on a stable dose for at least 6 weeks) exclusion criteria: * females who are pregnant or breast feeding * certain inflammatory conditions (other than rheumatoid arthritis), connective tissue diseases or chronic pain disorders. * previously taken, but not responded to, certain biological treatments for rheumatoid arthritis * high blood pressure that is not controlled by medication * low levels of neutrophils in the blood (blood test).

Keywords: rheumatoid arthritis
antipsychotic medication extended dosing study

Conditions: Schizophrenia

Summary: in patients stabilized on their antipsychotic and demonstrating evidence of good clinical response, there will not be a significant change in symptoms if their medication is decreased to every 2 days rather than daily. this decrease in antipsychotic exposure will lead to a reduction in side effects, as well as improved subjective response to treatment.

the present study is a 6-month, double-blind study of patients with schizophrenia stabilized on their current antipsychotic (monotherapy) for a period of at least 3 months. after providing informed consent, individuals will be randomly assigned to 1 of 2 treatment arms: regular daily antipsychotic dosing or active medication at the same daily dose every 2nd day. various scales to measure clinical response and side effects will be administered at baseline, as well as every 2 weeks thereafter. subjective scales will also be employed, and lab evaluations will include plasma antipsychotic levels at baseline and endpoint, as well as prolactin. our sample size will be 20/group.

Eligibility criteria:
inclusion criteria: * dsm-iv diagnosis of schizophrenia or schizo-affective disorder * capacity to provide written, informed consent * stabilized\* on a single oral antipsychotic for at least three months (excluding clozapine or quetiapine) * evidence of compliance with previous antipsychotic treatment, i.e. greater than 90% \* defined as 2 consecutively identical cgi evaluations (screening and baseline, at least one week apart) exclusion criteria: * exposure to depot antipsychotic during 12 months prior to enrollment * substance-related disorders according to dsm-iv

Keywords: schizophrenia schizoaffective antipsychotic randomized control trial
open-label extension study of mcs-2 in the treatment of lower urinary tract symptoms

Conditions: Lower Urinary Tract Symptoms; Benign Prostatic Hyperplasia

Summary: this is an open-label extension study of another study protocol, mcs-2-twn-a. subjects who have completed the 12-week treatment and procedures under the protocol mcs-2-twn-a will be eligible for this study.

this open-label extension study is designed to further assess the long-term safety and efficacy of mcs-2. subjects who have completed the 12-week treatment and procedures under the protocol mcs-2-twn-a will be eligible for another 40 weeks of mcs-2 treatment at the same daily dosage as the active treatment given under the protocol mcs-2-twn-a. subjects are limited to those who are currently not being treated medically for bph or luts.

Eligibility criteria:
inclusion criteria: * subject has completed 12 weeks of treatment under the protocol mcs-2-twn-a. * subject is able to understand and willing to conform to the study procedures and has signed the informed consent form for participation in this extension study. exclusion criteria: * subject has severe luts at the last visit under the protocol mcs-2-twn-a. * subject is considered ineligible for the study by the investigator(s).

Keywords: benign prostatic hyperplasia bph mcs-2 multi-carotenoids lower urinary tract symptoms international prostate symptom score
comparing the effects of extracorporeal shockwave therapy and splinting in the treatment of trigger finger

Conditions: Trigger Finger; Shockwave Therapy

Summary: the goal of this study is to compare the effects of extracorporeal shockwave therapy and splinting in the treatment of trigger finger. participants will: be randomized into two groups (shockwave group and splint group). visit the clinic once a week for four weeks for therapy. keep a diary of their symptoms, which will be reviewed at six weeks.


Eligibility criteria:
inclusion criteria: * patients age ≥ 18 years * grade i-iii trigger finger patients (patients who has the presence of tenderness over the a1 pulley or painful locking or triggering as they fixed and extended the finger) * patients who consented to participation in the study exclusion criteria: * trigger thumb * the patients who had received previous treatment (steroid injection, eswt or surgical release) * patients with local infections, malignancies, severe coagulopathy and pregnancy

Keywords: trigger finger shockwave
neuropathic pain and fabry disease

Conditions: Fabry Disease

Summary: fabry disease is a rare x-linked lysosomal storage disorder. the mutations result in a deficiency of the lysosomal enzyme α-galactosidase causing accumulation of glycosphingolipids in the vascular endothelial cells and many other tissues. an early sign of the disease is painful small fibre neuropathy presenting in two forms: 1. a constant burning sensation in the hand and feet and 2. fabry crises consisting of attacks of excruciating pain. given the x-linked inheritance, male patients are severely affected. recently attention has been drawn to female patients whether they also show signs of nerve involvement. the purpose of this study is to evaluate the small fibre neuropathy in female fabry patients. correlation with x-chromosome inactivation will be attempted. recombinant human α-galactosidase a is now available for patients. a part of this study is evaluation the long term efficacy of enzyme replacement therapy in female patients with fabry disease and neuropathy. male family members with fabry disease will be examined.


Eligibility criteria:
inclusion criteria: * all adult patients with confirmed fabry disease exclusion criteria: * patients who cannot cooperate * patients who are unable to understand the purpose
the effects of omega-3 fatty acids on peripheral arterial disease ii

Conditions: Peripheral Arterial Disease

Summary: investigators hypothesize that high-dose n-3 polyunsaturated fatty acids (pufa) oral supplementation will improve systemic inflammation, vascular function, and symptomatic status of patients with pad. investigators will explore novel mechanistic pathways by which n-3 pufa affect pad, evaluating the role of specialized lipid mediators involved in the resolution of inflammation.

the omega-pad ii trial will be a 1:1 randomized, double-blinded trial comparing oral supplementation of n-3 pufa (4.4g/day) to placebo in claudicants (rutherford stage 1-3) for 3 months. eligible patients will be screened according to specified inclusion and exclusion criteria. all patients will be treated per our current practice as reflected in the american heart association practice guidelines on pad. blood draws, vascular function testing and 6-minute walking tests will be performed at baseline and after 3 months. n-3 pufa supplementation will be achieved with 4 capsules of pro-omega twice daily (nordic naturals, watsonville, california, usa), corresponding to a total of 4.4g/day. each proomega capsule contains 325mg of epa and 225mg of dha. the placebo group will take the same number of capsules containing inactive substance (soybean; nordic naturals), designed to be the same color and shape as the treatment capsules.

Eligibility criteria:
inclusion criteria: 1. intermittent claudication (rutherford 1-3) 2. one of the following: 1. resting or exercise ankle-brachial index (abi) \<0.9 2. toe pressure \< 70 mm hg 3. documentation on imaging of greater than or equal to 50% stenosis in segments of aortoiliac arteries, femoral arteries, or tibial arteries 3. age 50 and more exclusion criteria: 1. critical limb ischemia 2. hypersensitivity/allergies to fish or seafood 3. already on n-3 pufa or equivalent 4. significant renal, hepatic, and inflammatory disease 5. concurrent severe infections 6. acute illness (myocardial infarction, stroke, major surgery within 30 days) 7. receiving immunosuppressive medications or steroids 8. age \< 50
unexplained early miscarriage : role and prevalence of lower genital tract infections

Conditions: First Trimester Abortion

Summary: the study group included 910 women who attended fayoum university hospital gynecology outpatient clinic for postabortive evaluation. the control group included 940 women attended outpatient clinic for any other procedure or complaint

the study group included 910 women who attended fayoum university hospital gynecology outpatient clinic for postabortive evaluation. the control group included 940 women attended outpatient clinic for any other procedure or complaint all patients were screened by serum samples to detect igm / igg to chlamydia trachomatis (drg chlamydia trachomatis igm / igg enzyme immunoassay) and by high vaginal and endocrvical swabs for bacterial, protozoal and chlamydial infection- examined by pcr- (from +ve samples to chlamydial igm / igg).

Eligibility criteria:
inclusion criteria: * the study group included women with recent unexplained early miscarriage (pregnancy duration 12 weeks or less and miscarriage within 4 weeks) * the control group included women with any other gynecological complaint or in need of family planning exclusion criteria: * miscarriage of pregnancy duration more than 12 ws documented causes of miscarriage as fetal or uterine anomalies, antiphospholipid syndrome, endocrine factors....etc * recent antibiotic, antifungal or antiprotozoal treatment
targeting cognitive immunization in depression

Conditions: Major Depressive Disorder

Summary: research has shown that people suffering from mdd tend to maintain dysfunctional expectations despite experiences that disconfirm expectations. recently, it has been shown that this persistence of expectations is due to maladaptive information processing involving "cognitive immunization". this experimental study aims at testing three different strategies to inhibit cognitive immunization, in order to enhance expectation change.

it appears adaptive to change one's expectations when continuously gaining expectation-disconfirming experiences; however, research has shown that people suffering from mdd have difficulty in changing their expectations after experiences that disconfirm expectations. recently, the investigators have shown that this persistence of expectations is due to maladaptive information processing involving "cognitive immunization", defined as a cognitive reappraisal of expectation-disconfirming experiences in such a way that the individual's expectations are maintained. in view of psychotherapeutic interventions aiming to modify patients' dysfunctional expectations, effective strategies to inhibit cognitive immunization strategies need to be identified. therefore, the aim of this study was to compare different immunization-inhibiting strategies with regard to their effectivity in enhancing expectation change. for this purpose, the investigators use a standardized experimental paradigm, which was developed and validated in a previous study.

Eligibility criteria:
inclusion criteria: * current diagnosis of major depressive disorder * at least 18 years old * sufficient german language knowledge exclusion criteria: - none