Kornimate/medical-research-clean huggingface dataset:
evaluation of the effect of virtual reality on pain in the management of chronic wounds.

Conditions: Chronic Wounds

Summary: pain management is a priority axis of health insurance spending objectives and contributes to improving the quality of care.there are several types of pain: acute, chronic and induced. these are often found in the management of chronic wounds. the high prevalence of chronic wounds represents a major public health problem. chronic wounds require long, painful and regular treatment. when dressing these wounds, pain management is essential. indeed, it can generate healing delays. usually, pharmacological methods are used to reduce the pain induced by care. but these methods can lead to undesirable effects. thus, new non-pharmacological techniques are emerging.the investigators therefore wish to assess the effect of virtual reality on pain induced by care during the repair of dressings in the management of chronic wounds.


Eligibility criteria:
inclusion criteria: * adults * knowing how to read and write french * able to understand the issues of the study and give consent * carrier of a chronic wound (ulcers, bedsores or wounds of the diabetic foot) * requiring a weekly dressing treatment in the department for at least 4 successive treatments(4 weeks) * with pain during pre-inclusion care at least ≥3 to the visual analog scale * person with cognitive and sensory capacities adapted to virtual reality (pre-inclusion verification on a device test of 5 to 10 minutes) * person affiliated or beneficiary of a social security scheme exclusion criteria: * carriers of a wound located on the face or end of the head and interfering with the proper use of the virtual reality mask * visually impaired and / or hard of hearing impacting the correct use of the virtual reality mask (test of 5 to 10 minutes of the device during the pre-inclusion visit) * patient not fluent in french. * current diagnosis of epilepsy, dementia or other neurological diseases preventing the use of virtual reality hardware and software * patients under guardianship or curators
treatment of onychomycosis with loceryl (amorolfine) nail lacquer 5% versus a two-course treatment with urea 40% ointment and bifonazole cream 1%

Conditions: Foot Dermatoses

Summary: the main objective of this study is to compare subject adherence and satisfaction for two modes of treatment toenails infection (onychomycosis) with loceryl nail lacquer (loceryl nl) and a fungal nail treatment set containing urea 40% ointment (urea) and bifonazole cream 1% (bifonazole).

a total of 20 subjects are to be included in 1 site in iceland methodology: subjects will receive following treatments on the right or left toenails: * loceryl nail lacquer (loceryl nl) to be applied once weekly for 7 weeks on all affected toenails of one foot (including great toenail) * fungal nail treatment set to be used on all affected toenails (including great toenail) of the opposite foot in two phases: * phase i: urea ointment (urea) to be applied once a day under occlusion for 2-3 weeks depending on the achievement of optimal diseased toenail plates removal * phase ii: bifonazole cream to (bifonazole) be applied for 4 weeks on affected toenails (after the maximum 3-week treatment period with urea ointment)

Eligibility criteria:
inclusion criteria: * subjects with clinically distal and lateral subungual onychomycosis (dlso) due to dermatophytes and/or yeast (including candida) on at least one great toenail of each foot at screening visit, * subjects with less than 50% of the toenail surface area from the distal edge with disease involvement and without matrix involvement, no dermatophytoma, streaks (spikes) or subungual hyperkeratosis \> 2mm, * subjects should have the same number of affected toenails on both feet or no more than one additional affected toenail on one of the feet, * subjects with positive mycological results (direct microscopy and culture) of the most affected toenail (or great toenail) for dermatophytes or yeast (including candida) at baseline exclusion criteria: * subjects with matrix involvement on the great toenails, * subjects with a surgical, medical condition or clinically important abnormal physical findings which might interfere with the interpretation of the objectives of the study * post-traumatic toenail, lichen planus, eczema, psoriasis, or other abnormalities of the nail unit, which could affect/influence the subject's compliance with the investigational products or mask the effects of treatment (cure), * known immunodeficiency, radiation therapy, immune suppressive drugs,

Keywords: onychomycosis
different modalities of management of odontogenic keratocysts

Conditions: Odontogenic Cysts

Summary: background the odontogenic keratocysts (okcs) have been one of the maxillofacial region's most contentious pathological phenomena. decompression/marsupialization (d/m), enucleation (e), enucleation + chemical cauterization with carnoy's solution (e+cs), enucleation + peripheral ostectomy (e + po), as opposed to enucleation + chemical cauterization with carnoy's solution + peripheral ostectomy (e + cs + po), were used during surgery to ensure that no epithelial remnants were left behind. rationale through the management of okc a recurrence could occur, the effectiveness of decompression/marsupialization (d/m), enucleation (e), enucleation+carnoy's solution chemical cauterization (e+cs), enucleation+peripheral ostectomy (e+po), enucleation+carnoy's solution chemical cauterization + peripheral ostectomy (e+cs + po), will be analyzed

since the middle of the 20th century, the odontogenic keratocyst (okc) has been one of the maxillofacial region's most contentious pathological phenomena. it was initially misdiagnosed as a primordial cyst. after that, because of its severe clinical behavior and tendency to recur, it was no longer considered to be a part of its classification, also known as a odontogenic tumor. then, in 2017, the okc are re-classified as a cystic lesion. but still there is debate about their management. so, this study will be enrolled with the following objectives: to describe how odontogenic keratocysts are managed, to discover the most favorable approach to manage okc with the need to stop it from happening again to categorize the odontogenic keratocyst management outcomes into to the subsequent groups: (1) total resolution, (2) partial resolution; (3) recurrence.

Eligibility criteria:
inclusion criteria: * all odontogenic keratocysts that are treated by the following surgical treatment modalities: 1. enucleation followed by peripheral ostectomy and carnoy's solution 2. decompression/ marsupialization 3. enucleation 4. enucleation and carnoy's solution 5. enucleation and peripheral ostectomy * follow-up period 10 years exclusion criteria: * cases treated with resection * cases showed neoplastic transformation in their pathology * cyst like lesions

Keywords: odontogenic cysts odontogenic keratocysts
evaluation of culture-specific popular music as a mental metronome for cardiopulmonary resuscitation

Conditions: Cardiac Arrest; Out-of-hospital Cardiac Arrest

Summary: abstract introduction bystander cardiopulmonary resuscitation (cpr) can more than double the patient's chance of survival in out-of-hospital cardiac arrest (ohca). in singapore, bystander cpr rate was low. recent studies have proposed and validated the use of popular songs as aids in performing cpr. these songs may not be widely known when applied to a different population, and further, may lose popularity over time. "count on me singapore" (coms) is believed to be known to over 90% of the singapore population. pilot data indicated that cpr performed using coms as a mental metronome (comscpr) can achieve guideline-compliant rate of chest compression with lower fatigue level than cpr guided by the conventional "one-and-two-three-and" (standard cpr). the investigators hypothesize that comscpr is non-inferior to standard cpr in achieving guideline-compliant rate of chest compression. methodology the investigators planned a prospective, randomized, crossover non-inferiority trial comparing coms cpr and standard cpr. 80 eligible volunteers will be recruited from a convenience sample of camp personnel from a military training camp. after a 15 minutes familiarization session, they will be randomized into two groups (a and b). group a will proceed to perform one cycle (two minutes) of standard cpr, while group b will proceed to perform one cycle of coms cpr. participants will cross over to perform one cycle of the other method of cpr. after completing this second cycle, a survey form will be administered. the laerdal skillreporter will be used to measure the cpr performed. after a 7-14 days interval, participants will be recalled to attend a test scenario. statistical analysis will be used to compare the two arms.


Eligibility criteria:
inclusion criteria: * all volunteers are eligible. this mimics a real world situation where any trained member of the public can provide bystander cpr. exclusion criteria: * lack of informed consent * existing medical conditions that may cause danger to the participant (e.g. cardiac conditions or musculoskeletal injuries) * recent cpr course attended (within past one month)
effects of chronic intake of processed foods on circulating inflammatory markers in healthy men

Conditions: Inflammation

Summary: this study aims to investigate the effects of diets enriched or depleted in foods at high risk of containing pro-inflammatory bacterial molecules, on markers of inflammation and cardiometabolic risk in healthy men. the study design is an interventional diet study, with 7 days dietary advice to avoid processed foods, followed by 4 days in which lunch and evening meal are provided to volunteers. anthropometric and blood markers of cardiovascular disease risk are measured at the start and end of each dietary phase. the aim is to gain an improved understanding of how processed foods modify risk of cardiometabolic disease.

this study aims to investigate the effects of diets enriched or depleted in foods at high risk of containing pro-inflammatory bacterial molecules, on markers of inflammation and cardiometabolic risk in healthy men. the study design is an interventional diet study, with 7 days dietary advice to avoid processed foods, followed by 4 days in which lunch and evening meal are provided to volunteers. anthropometric and blood markers of cardiovascular disease risk are measured at the start and end of each dietary phase. the aim is to gain an improved understanding of how processed foods modify risk of cardiometabolic disease. three blood samples, each of 15 ml, will be taken on days 0, 8 and 12. measurements at each timepoint include weight, waistline, serum low-density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, insulin, leptin, c-reactive protein and endotoxin. volunteers will be requested to avoid processed foods, ready-prepared meals, foods containing minced meats, foods containing ready-chopped vegetables, cheese or chocolate for the first 7 days of the study. for days 8 to 11, volunteers will be provided with meals, purchased from local supermarkets, which from previous tested were found to contain high levels of bacterial pro-inflammatory molecules (pamps). diet diaries collected during the study will be combined with diet recall information to investigate habitual and on-study frequency of consumption of specific food groups.

Eligibility criteria:
inclusion criteria: * healthy male consenting volunteers * age 18-60 exclusion criteria: * any existing inflammatory condition, such as chronic kidney disease, inflammatory bowel disease, coronary artery disease or rheumatoid arthritis * evidence of an infection within the last two weeks * users of prescription medications * vaccination within the last two weeks
intravenous ibuprofen postoperative analgesia after abdominal hysterectomy

Conditions: Post Operative Analgesia

Summary: the current research is designed to investigate the analgesic efficacy of intravenous ibuprofen on the postoperative analgesic requirements, pain intensity and other recovery parameters.

the patients will be given general anaesthesia. anaesthesia will be induced by propofol 1-2 mg/kg, and fentanyl 1-2 µg/kg. endotracheal intubation will be facilitated by atracurium 0.5 mg/kg. anaesthesia will be maintained by isoflurane in oxygen - air mixture. transversus abdominis plane block will be performed at the end of the operation. a postoperative analgesic regimen according to group allocation will be started.

Eligibility criteria:
inclusion criteria: * american society of anaesthesiologists physical status i to iii. * open abdominal hysterectomy operations exclusion criteria: * history of gastrointestinal bleeding. * history of intracranial haemorrhage. * pregnancy and lactation. * taking angiotensin converting enzyme(ace) inhibitors or anticoagulation drugs. * asthmatic, hepatic,renal or heart failure. * abnormal platelet count.
influence of pbm on anaerobic capacity under normoxia and hypoxia

Conditions: Low Level Laser Therapy; Photobiomodulation; Performance; Sport

Summary: the photobiomodulation (pbm) shows positive results in muscle performance, fatigue reduction, management of blood lactate production, analgesia and in the increase of vo2 maximal, favoring the increase of atp production and thus the energy metabolism. the association of pbm applied before high-intensity treadmill training shows physiological improvements both in normoxic (nor) and hypoxic (hip) conditions. anaerobic capacity (ac) is the maximum amount of atp that can be resynthesized by anaerobic metabolism and is an important predictor of high-intensity exercise since an athlete's ability to perform efforts to increase maximal oxygen consumption (vo2max) depends on al. in view of the above information the main objective of the present research project will be to investigate the effects of pbm on ac under normoxic and hypoxic conditions in amateur runners. to test the effects of exercise training on anaerobic capacity under normoxic and hypoxic conditions, 7 individuals will be randomly submitted to four maximal efforts to exhaustion with intensity corresponding to 110% of vo2max in hip, nor, hip+ebio and nor+ebio conditions. these efforts will be used to estimate the ac, that is, the maximum accumulated deficit of alternative oxygen (maodred), from the sum of the energy contribution of the anaerobic and lactic metabolisms.


Eligibility criteria:
inclusion criteria: * healthy individuals * vo2 maximal equal to or greater than 34 ml/kg.min * capacity for physical activity according to the par-q questionnaire exclusion criteria: * musculoskeletal injury in the last three months; * cardiovascular diseases; * use of anabolic, anti-inflammatory and analgesic drugs 72 hours before the evaluations; * use of alcohol and illicit drugs during the collection period;

Keywords: physical therapy photobiomodulation athletic performance hypoxia
diversion-p64 post market clinical follow-up study to assess safety and effectiveness of the p64 flow modulation device

Conditions: Intracranial Aneurysm

Summary: the purpose of this study is to assess safety and effectiveness of the p64 flow modulation device.

title: diversion-p64. device: p64 flow modulation device. study design: prospective, multicenter, single arm post market clinical follow-up study. purpose: to assess safety and effectiveness of p64. study duration: 48 months. sample size: 400 patients. number of sites: \> 20. follow-up intervals: two independent follow-ups (after 3-6 and 7-12 months) according to site specific standard.

Eligibility criteria:
inclusion criteria 1. age ≥ 18 2. patient harbours either one saccular or one dissecting or one blisterlike or one fusiform intracerebral aneurysm or one intracerebral segmental disease, in the anterior circulation for which the indication for p64 treatment is given 3. patient or legal representative provides written informed consent verifying that he/she consents to the use of his/her data (according to the data protection laws) exclusion criteria 1. aneurysms of the posterior circulation 2. imaging evidence of bifurcation aneurysms 3. imaging evidence of dissections 4. imaging evidence of fistulae 5. imaging evidence of arteriovenous malformations 6. patient is harbouring another aneurysm that has to be treated within six months after first procedure 7. known allergy to study medication, e.g. asa, clopidogrel, heparin or contrast media 8. confirmation of positive pregnancy test according to site specific standard of care (e.g. test, verbal communication) 9. current involvement in another study or trial 10. parent vessel treated with other flow diverters than p64 during intervention and re-treatment

Keywords: aneurysm intracerebral stroke p64
grocery prescription program for medicaid adults with hypertension or type 2 diabetes

Conditions: Type 2 Diabetes Mellitus; Hypertension

Summary: the purpose of this study is to evaluate the effectiveness of a grocery prescription program in adults diagnosed with either type 2 diabetes mellitus or hypertension. participants will enroll in instacart fresh funds program. once enrolled each week participants will select foods that are eligible in the fresh funds program to be delivered to their home for 12 weeks. participants will also participate in a survey at the beginning of the study and at the end of the study.


Eligibility criteria:
inclusion criteria: * diagnosis of type 2 diabetes mellitus, hemoglobin a1c = 7.0% and = 12.0% in last 12 months, or diagnosis of hypertension * experiencing food insecurity as indicated by 2-item hunger vital sign * english speaking * no plans to move from the area for at least 1 year * willing and able to accept text messages * free living to the extent that participant has control over dietary intake * willing and able to provide written informed consent and participate in all study activities. exclusion criteria: * participant in diabetes, nutrition, or weight research intervention in last 12 months * another member of the household is already enrolled in this study * considering bariatric surgery in the next year or prior bariatric surgery * lack of safe, stable residence and ability to store meals

Keywords: food insecurity food as medicine medicaid adults
impact of chemotherapy on ovarian reserve in young women with breast cancer

Conditions: Ovarian Reserve

Summary: the aim of this protocol is to study the deleterious impact of adjuvant chemotherapy or neoadjuvant chemotherapy on ovarian reserve in young women suffering from breast cancer. a new relevant ovarian reserve marker, serum anti-mullerian hormone, will be used in order to evaluate precisely the impact of chemotherapy on ovaries during chemotherapy administrations and after during follow-up (24 months). this strategy offers 2 main advantages : no modification of the traditional care of patients (treatment, organisation, follow up ...) and use of a non invasive marker (serum). the final objective is to give precise information to patients on their future fertility after remission.


Eligibility criteria:
inclusion criteria: * female 18-39 years * suffering from breast cancer * treated with adjuvant or neoadjuvant chemotherapy

Keywords: breast cancer ovarian reserve anti-mullerian hormone (amh) chemotherapy
influence of using physical therapy resources for knee osteoarthritis

Conditions: Osteoarthritis; Physical Therapy Modalities

Summary: osteoarthritis is a chronic, multifactorial characterization, which changes in bone alignment, cartilage and structures that provide joint stability appear to be strongly correlated with the origin of this disease.this project will aim to verify the effectiveness of interferential current, short wave and low level laser therapy on an exercise program for mobility and pain in knee osteoarthritis. blind randomized, placebo controlled. five groups: exercise group, exercise group + ultrasound therapy, exercise group + interferential current, exercise group + short-wave diathermy, exercise group + low level laser therapy. before and after the trial protocol by the following instruments: western ontario and mcmaster universities osteoarthritis index (womac), numerical scale of pain assessment (end), visual analogue scale fatigue (vas-f), issue f2.2 instrument assessment of quality of life of the world health organization (whoqol-100) test sitting and standing + numerical rating pain scale, algometry. this project hypothesizes that the inclusion of photothermal and electrical agents in an exercise program will provide an improvement in pain, mobility and knee function in individuals diagnosed with knee osteoarthritis.


Eligibility criteria:
inclusion criteria: * knee pain to at least six months and minimum of 4 points in pain scale * diagnosed with osteoarthritis in unilateral knee according to the criteria established by the american college of rheumatology and confirmed by radiographic examination for identification kellgren-lawrence grade 2 or 3 (kellgren \& lawrence, 1957). exclusion criteria: * any type of physical therapy * therapy with intra-articular corticosteroids or therapeutic chondroprotective drugs last year, before the start of the study. * history of trauma on his knees, cognitive disorder or psychological disorder, * neurological (sensory or motor) * cancer * diabetes, * or any state of adverse acute health osteoarthritis signs of hip * cardiopulmonary disease that prevents the conducting exercises * require auxiliary device for performing gait. * yet who undertake physical activity in the last two months. physical activity is defined as strength training and / or more than 20 minutes of aerobic activity twice a week.
arrhythmias in patients with covid-19

Conditions: COVID-19

Summary: the study is a prospective clinical cohort study of consecutive patients hospitalized at all hospitals of greater copenhagen with a laboratory confirmed diagnosis of covid-19. the investigators aim to examine if continuous ecg monitoring can be used to understand the contribution of covid-19 infection in the acute phase to the development of cardiac arrhythmias, especially focusing on cardiovascular outcomes. in all patients included, the investigators aim to examine if continuous ecg monitoring - alone and in combination with biomarkers - can be used to detect early signs of cardiac complications and predict long-term risk of cardiovascular morbidity and mortality following covid-19 infection.


Eligibility criteria:
inclusion criteria: * all patients hospitalized at hospitals of greater copenhagen area and zealand with a laboratory confirmed diagnosis of covid-19 \> 18 years of age. exclusion criteria: * persons not able to cooperate * persons unable to understand and sign "informed consent"
the yield of laryngeal ultrasound in the diagnosis of laryngomalacia

Conditions: Stridor; Laryngomalacia

Summary: the hypothesis of the study is that laryngeal us can accurately and reliably diagnose laryngomalacia in infants with congenital stridor. stridor is a respiratory noise caused by partial obstruction of the large airways at the level of the pharynx, larynx and/or trachea. the most prevalent congenital cause of stridor is laryngomalacia. flexible laryngobronchoscopy (flb) under sedation is regarded as the gold standard. however, flb under sedation has some drawbacks as it requires venous access, use of sedative agents, may cause discomfort for the patient and is costly. ultrasound (us) is a noninvasive, painless, radiation free, well tolerated imaging technique. it allows for dynamic assessment of moving structures in an awake patient and the results can be easily displayed and recorded.


Eligibility criteria:
inclusion criteria: infants referred for flb and bronchoscopy due to congenital stridor at the department of pediatric pulmonology, critical care and sleep medicine at the tel aviv sourasky medical centre exclusion criteria: * prior knowledge of the cause for stridor * history of foreign body aspiration

Keywords: stridor laryngomalacia ultrasound