Kornimate/medical-research-clean huggingface dataset:
clinical study of dc plus cik for patients with relapse acute leukemia after allo-hsct

Conditions: Acute Leukemia

Summary: allogeneic hematopoietic cell transplantation(allo-hsct) is currently an effective treatment for acute leukemia (al). relapse after transplantation, being a main obstacle for patient survival, is so far treated by second transplantation and donor leukocyte infusion (dli), which seems to have high risk and low survival. need for a new medication on relapse is urgent. the immunotherapy using dendritic cells (dcs) combined with cytokine induced killer (cik) cells holds promise for the adjuvant treatment of al to eradicate or control residual disease. this randomized study was conducted to evaluate the feasibility and effective of genetically modified dcs combining to cik immunotherapy in relapse al after allo-hsct.


Eligibility criteria:
inclusion criteria: * al patients according to the who criteria * expected survival duration of more than 3 months * age between 8 and 61years exclusion criteria: * underlying autoimmune disease * positive serology for hiv infection * chronic active hepatitis
ventaprost versus conventionally-administered aerosolized epoprostenol in patients undergoing cardiac surgery with cpb

Conditions: Pulmonary Hypertension

Summary: the purpose of the phase 2a study is to: 1) demonstrate that the estimated ventaprost dose is safe and equivalent in effect to a dose administered via epoprostenol aerosolization by the current off-label-use practice; and 2) demonstrate that an optimum effect can be rapidly obtained with ventaprost titration.

part i: this part of the study is designed to demonstrate the dose equivalence between off-label aerosolized epoprostenol and ventaprost using a patient's hemodynamic parameters. part ii: this part of the study is designed to establish a dose response relationship of ventaprost to hemodynamic effect by dose escalation in patients who have had cardiac surgery with cpb.

Eligibility criteria:
inclusion criteria: 1. women and men 18 to 75 years of age 2. provide written informed consent 3. willing and able to comply with all aspects of the protocol 4. for patients in part i: 1. undergo cardiac surgery on cpb 2. clinically require treatment with and receive aerosolized epoprostenol 3. demonstrate a clinically meaningful hemodynamic response to aerosolized epoprostenol 5. for patients in part ii: 1. undergo cardiac surgery with cpb 2. have perioperative pulmonary hypertension 3. clinically require treatment with inhaled epoprostenol exclusion criteria: 1. current smoker (i.e., within the last 30 days) 2. emergency operative status 3. upper and/or lower respiratory tract infection within four weeks of screening 4. contraindication to transesophageal echocardiogram (tee) including esophageal disease or unstable cervical spine 5. renal or severe hepatic impairment 6. thromboembolic disease treated with anticoagulant therapy 7. bleeding disorders 8. significant restrictive or obstructive lung disease 9. history of concurrent malignancy or recurrence of malignancy within two years prior to screening 10. history of a diagnosis of drug or alcohol dependency or abuse within approximately the last three years 11. recent history of stroke or transient ischemic attack 12. significantly abnormal laboratory tests at screening 13. pregnant or breastfeeding 14. treatment with an investigational drug, biologic, or device within 30 days 15. other severe, acute, or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or investigational product administration or may interfere with the interpretation of trial results and, in the judgment of the investigator or sponsor, would make the patient inappropriate for entry into this trial 16. any condition where aerosolized epoprostenol is contraindicated 17. known allergy or sensitivity to epoprostenol, any of its ingredients, or the diluent

Keywords: cardiac surgery cardiopulmonary bypass epoprostenol
clinical trials of regeneration for periodontal tissue

Conditions: Adult Periodontitis

Summary: adult periodontitis is a chronic infective disease affecting the periodontium. periodontitis induce the destruction of attachment apparatus of teeth, resulting in periodontal pocket formation and teeth loss. this study will test the safety and efficacy of alveolous bone reproduction by the transplantation of mixture named periodontium injectable gel for the adult periodontitis patients. injectable gel is the mixture of ex-vivo cultured mesenchymal stem stem cells, ex-vivo cultured osteoblast-like cells differentiated from mesenchymal stem cells and scaffold (include, platelet rich plasma, human thrombin and calcium chloride).

periodontal disease is an infectious disease. gingivitis and periodontitis are the 2 major forms of this. their primary etiology is bacterial plaque, which can induce destruction of the periodontal apparatus. gingivitis is inflammation of the gingival that does not result in clinical attachment loss. periodontitis is inflammation of the gingival and is characterized by loss of connective tissue attachment and alveolar bone. therapeutic approaches for periodontitis are divided into two categories: 1) anti-infective treatment; 2) regenerative therapy. several surgical techniques have been developed to regenerate periodontal tissues including guided tissue regeneration, bone grafting, the use of enamel matrix derivative. however, these techniques are not reached for complete regeneration of the periodontium. this study will test the safety and efficacy of alveolous bone reproduction by the transplantation of mixture named periodontium injectable gel for the adult periodontitis patients. injectable gel is the mixture of ex-vivo cultured mesenchymal stem stem cells, ex-vivo cultured osteoblast-like cells differentiated from mesenchymal stem cells and scaffold (include, platelet rich plasma, human thrombin and calcium chloride).

Eligibility criteria:
inclusion criteria: * 1.patient with adult periodontitis. 2. there are ４mm or more pocket using . 3.there are ten existing tooth or more of the lower jaw. 4.the brushing instruction is received, and the plaque control is maintained excellently. 5.the recovery by an existing periodontal operation cannot be expected. 6.the age is from 35 to 60 years old. 7.blood clot function is normal. 8.the liver function is normal. 9.the intention and the ability of going to hospital regularly are possessed. 10.agreement by the document is obtained. exclusion criteria: * 1.patient who has acute symptom of periodontitis. 2.patient that decayed tooth is on teeth or the next teeth to be treated. 3.patient who has contracted diabetic or autoimmune disease. 4.patient who has contracted infectious disease. 5.patient who has contracted osteoporosis. 6.patient who has smoking habit within six months before it registers. 7.patient who is taking treatment of hypertension and/or epilepsy. 8.patient who has pregnancy or doubt of pregnancy. 9.patient who has heavy allergic disease.

Keywords: regenerative medicine periodontal tissue
study of impact of art therapy sessions given to family caregivers of children with type 1 diabetes

Conditions: Quality of Life

Summary: diagnostic of diabetes in childhood brought modification of family way of life, particularly in child and caregivers lifes. the education patient programs are in france centered on curative competencies of care. it is possible that art-therapy improve psycho-social competencies the aim of the study is to evaluate art-therapy sessions on quality of life of caregivers


Eligibility criteria:
inclusion criteria: * one of the family caregivers of child with diabetes enrolled in patient education programs of 3 hospitals (hospital of poitiers, hospital of niort and hospital of la rochelle) * who accept the study * ≥ 18 years * free, with protection of vulnerable adult * caregivers of child with who have insurance * with free, enlightened, signed consent exclusion criteria: * other research participation * \< 18 years * host family * with protection of vulnerable adult * caregivers of child with who have not insurance

Keywords: art therapy caregiver's
intestinal microbiota, tryptophan and autism

Conditions: Autism Spectrum Disorder

Summary: autism spectrum disorder refers to complex neuro-developmental disorders that affect social communication and behavioral adaptation. currently, the diagnosis of autism spectrum disorder is based on a clinical examination that is performed classically during the first three years of life. the heterogeneity of the disorders occurring in autism make pathologies difficult to diagnose and manage. the overall goal of this project is the identification of metabolic biomarkers based on clinical profile. the best characterization of physiopathological pathways will ultimately allow the identification of subgroups of subjects and facilitate the development of targeted therapeutics. the proposed work aims to test the hypothesis of a disruption of tryptophan metabolism in autism spectrum disorder via the gut microbiota.

autism spectrum disorder refers to complex neuro-developmental disorders that affect social communication and behavioral adaptation. in france, autism spectrum disorderaffects about 1 in 100 people according to international criteria and is diagnosed in early childhood. currently, the diagnosis of autism spectrum disorder is based on a clinical examination that is performed classically during the first three years of life. the heterogeneity of the disorders occurring in autism make pathologies difficult to diagnose and manage. the overall goal of this project is the identification of metabolic biomarkers based on clinical profile (based on behavioral and cognitive markers). the best characterization of physiopathological pathways (from the molecular scale to the phenotypic scale) will ultimately allow the identification of subgroups of subjects and facilitate the development of targeted therapeutics. the proposed work aims to test the hypothesis of a disruption of tryptophan metabolism in autism spectrum disorder via the gut microbiota.

Eligibility criteria:
inclusion criteria (patient): * 3-12 year old child * diagnosis of autism spectrum disorders according to the dsm-5 (2013), invasive developmental disorder according to the icd-10 (1993) or autism spectrum disorders according to icd-11 (2018) * affiliate or beneficiary of a social security scheme * consent signed by at least one of the parents exclusion criteria (patient): * chronic inflammatory pathology * probiotic intake * taking medication (except melatonin) within 6 days before inclusion and until biological samples are collected inclusion criteria (healthy volunteer): * 3-12 year old child * affiliate or beneficiary of a social security scheme * consent signed by both parents exclusion criteria (healthy volunteer): * chronic inflammatory pathology * digestive pathology * probiotic intake * taking medication within 6 days before inclusion and until biological samples are collected * personal and / or family history of neurological disease, epilepsy, psychiatric disorder, neurodevelopmental disorder, language disorder, overdrive, intellectual disability

Keywords: autism spectrum disorder tryptophan metabolism gut microbiota
cementless alumina-alumina total hip and hybrid

Conditions: Rheumatoid Arthritis; Osteoarthritis; Post-traumatic Arthritis; Avascular Necrosis

Summary: evaluate the safety and efficacy of the ceramtec acetabular alumina insert and ceramtec alumina head when used with the foundation porous coated acetabular shell and an encore hip stem.


Eligibility criteria:
inclusion criteria: * patients with inflammatory tissue disorders (e.g. rheumatoid arthritis, lupus, etc), osteoarthritis, post-traumatic arthritis or secondary arthritis, or avascular necrosis. * less than 70 on preoperative hhs score * primary total hip replacement * patient is likely to be available for evaluation for the duration of the study. exclusion criteria: * patients with physical conditions that would eliminate adequate implant support or prevent the use of an appropriately sized implant (e.g., tumor) * previous surgery that has adversely affected bone stock (such as some hip pinning or some osteotomies) or prior total hip replacement. * insufficient quality or quantity of bone resulting from conditions such as: * cancer, where radiation has destroyed the available bonestock * congenital dislocation * metabolic bone disease of the upper femur or pelvis * femoral osteotomy revision * girdlestone revision * active infection of the hip joint * old or remote infection * other conditions that lead to inadequate skeletal fixation * neurological conditions that might hinder patient's ability to follow study procedures, e.g., to restrict physical activities (e.g., severe parkinson's, cva on affected side) * patient's mental condition that may interfere with his ability to give an informed consent or willingness to fulfill the required follow-up of the study * mental illness * senility * drug abuse * alcoholism * conditions that place excessive demands on the implant * charcot's joints * muscle deficiencies * multiple joint disabilities * refusal to modify postoperative physical activities * skeletal immaturity * obesity (50% over recorded body weight mass index) * greater than or equal to 70 on preoperative hhs score
westlake precision nutrition study 2 (weprecision2)

Conditions: Healthy; Overweight and Obesity

Summary: this is a dietary intervention study, which aims to explore different diet challenges for glucose metabolism, including carbohydrates and fasting dietary pattern. considering the glucose responses to the same food are largely heterogeneous among people, this study integrates the concepts of precision nutrition and n-of-1 design. the study also aims to discover the different impact of the time-restricted diet (trd) and the energy-restricted diet (erd) on host metabolic health and our hair growth.

the project is mainly based on classic field trial study design to compare impacts of different fasting patterns on host metabolic health. under the condition of controlled diet background, individual n-of-1 study design is also organically integrated to compare personalized responses for standard meal tests. participants will be required to wear continuous glucose monitoring (cgm) for 14 days. the diet intervention will be carried out after wearing cgm on day 1. then, all participants will be divided into three groups: energy-restricted diet (erd), 18:6 time-restricted diet (trd), and normal diet (nd). during day 3 to day 12, erd restricts daily total energy intake within 1200-1500 kcal without meal timing limits, while trd restricts the daily feeding window from 10:00 to 16:00, without total energy intake restriction. nd will maintain volunteers' original eating habits and rhythms as the control group. individual n-of-1 trial design will be employed to all participants during day 3 to day 12 to compare the difference of postprandial glucose response to white bread or plain oats. these two standard breakfasts will appear in pseudo-random order. the trd group needs to adjust the breakfast time to after 10:00 in the intervention periods.

Eligibility criteria:
inclusion criteria: * participants have completed weprecision trial in 2021 * participants reside in hangzhou * participants have no traveling plans within 3 months exclusion criteria: * participants with metabolic diseases including diabetes, hypertension and cardiovascular diseases (cvd) * participants with craniocerebral trauma, cancer, liver disease, kidney disease, or other critical illness, or history of operation or medication * participants with bulimia nervosa, post-traumatic stress disorder (ptsd), chronic anxiety and depression or other critical neuronal disorder or history of relevant medication * being or to be pregnant or lactating. * participants with history of alcohol or drug addiction, or smoke above 15 cigarettes per day * concurrently participating other clinical trials.

Keywords: personalized nutrition n-of-1 fasting glucose metabolism hair growth
evaluation of the efficiency of two different teaching methods in safe subcutaneous injection skills

Conditions: Complication of Injection

Summary: subject: subcutaneous (sc) insulin injection is frequently used in the treatment of type 2 diabetes patients. complications such as pain, ecchymosis, hematoma, lipoatrophy and lipohypertrophy are frequently observed after sc injections. these complications that develop due to incorrect injection application negatively affect the use of injection application areas, change body image and negatively affect drug absorption. in order to reduce and prevent complications related to sc insulin injection, it is very important to gain the skill of safe sc insulin injection. it is stated that there are a limited number of studies on which of the teaching methods used in sick individuals are effective. in the national and international literature, no study has been found evaluating the effect of sc injection skill teaching based on video-supported training and low-fidelity simulation model applications on disease management in individuals diagnosed with type 2 diabetes mellitus. in this regard, the research was planned as an experimental design in order to examine the effectiveness of video-supported training and low-fidelity simulation model-based teaching in gaining safe insulin injection skills via sc. for this purpose; it is aimed to evaluate the effect of two different skill teaching methods on the patient's sc injection ability, complication management and blood glucose level. purpose: this research was planned as an experimental design to examine the effectiveness of two different teaching methods (video-supported training and low-fidelity simulation model) in gaining safe insulin injection skills via the subcutaneous (sc) route. design: a pretest-posttest two-group, quasi-experimental design will be used in the study.


Eligibility criteria:
inclusion criteria: * the patient must be 18 years of age or older, * have the physical and mental ability to accurately evaluate the visual analog scale (vas), * the platelet count is 100 000/mm3 and above, * having a diagnosis of type 2 diabetes mellitus, * no dementia according to mini-cog test evaluation, * the plan was to agree to participate in the study. exclusion criteria: * having verbal and auditory problems, * using oral or sc anticoagulant * presence of any findings such as scarring, incision, ecchymosis, hematoma, lipoarthrrophy and lipohypertrophy on the skin in the area where the injection will be made, * recurrent use of drugs that affect the formation of lipoatrophy and lipohypertrophy, such as octroid, corticosteroid, and antiretroviral therapy, * it was defined as having a diagnosis of diabetes during pregnancy.

Keywords: video-assisted training practice skill nursing
spinal mobilization versus myofacial release techniques on pain and disability in patients with tension type headache

Conditions: Tension Type Headache

Summary: the most frequent kind of primary headache is tension headache, often known as stress headache or tension-type headache (tth). the pain usually affects both sides of the head and might extend from the lower back of the head, the neck, the eyes, or other muscle groups in the body. nearly 90 percent of all headaches are tension-type headaches causing a debilitating effect on job productibility and overall quality of life. the aim of the study will be to compare the effects of spinal mobilizations comprising mulligan's headache snags and maitland's pa glide with the myofascial release technique on pain and disability in patients with tension-type headache.

a randomized clinical trial will be conducted at fmh physiotherapy clinic, nur international physical therapy clinic and boston physiotherapy clinic lahore through consecutive sampling technique on 34 patients which will be allocated using simple random sampling through sealed opaque envelopes into group a and group b. group a will be treated with spinal mobilizations comprising mulligan's headache snags and maitland's pa glide and group b will be treated with myofascial release technique. outcome measures tools will be conducted through nprs, headache disability index, headache impact test (hit-6). data will be analyzed using spss software version 25. after assessing normality of data by shapiro-wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups

Eligibility criteria:
inclusion criteria: * • male and female between ages of 30-60 years * presence of 2 or more of the following: bilateral headache, pressure or squeezing pain, mild or intermediate pain intensity, and headache not elicited by daily physical activities * headache lasting between 30 minutes and 7 days * patients with no increase in pain during physical activity * patients not having any photophobia, phonophobia during headache * headache unaccompanied by vomiting or nausea exclusion criteria: * any other primary or secondary headache according to the ichd-iii criteria. * a history of neck or head trauma (e.g., whiplash). * any red flags (vertebral tumor, fracture, dislocation and infection, metabolic diseases, rheumatic and connective tissue diseases, systemic neuromuscular diseases, prolonged history of steroid use). * diagnosis of any structural spinal disorders (osteoporosis, disc herniation, myelopathy, spinal stenosis, spondylolisthesis). * prior surgery to the cervical spine.

Keywords: tension type headache
role of echocardiography in guiding fluid therapy in shocked patients with impaired cardiac contractility in emergency department

Conditions: Shock

Summary: fluid therapy is one of the cornerstones in the management of shock but may result in iatrogenic fluid overload .the aim of this study was to assess the role of echocardiography in guiding fluid therapy in shocked patients with impaired cardiac contractility using straight leg raising test ,inferior vena-cava collapsability index and doppler imaging in emergency department in alexandria main university hospital.


Eligibility criteria:
inclusion criteria: * shocked patient with impaired cardiac contractility exclusion criteria: * trauma patients. * patient with unstable arrhythmias. * patients with lower limb amputation. * mechanically ventilated patients. * patients with prosthetic aortic valve. * patients less than 18 years old * pregnant.