Kornimate/medical-research-clean huggingface dataset:
evaluation of the efficacy and tolerability of abo/meg-b-09 in children with acute cough

Conditions: Cough

Summary: the present clinical trial will examine the use of abo/meg-b-09 syrup in children with acute cough as compared to a placebo syrup.

subjects will be asked to take 4 doses of 5 ml containing a mixture of honey and other natural ingredients or a placebo syrup everyday, during 8 days. the following outcomes will be noted down in a diary: occurence and severity of diurnal and nocturnal cough events (cough score) and symptoms, impediment of normal life activities (school, sleeping), the number of medical visits and type of medication needed if any.

Eligibility criteria:
inclusion criteria: * children aged between 3 and 6 * acute cough - lasting 1-3 weeks * written informed consent by the parents/legal tutors * parents/legal tutors must be willing not to give to the child other medications or products for the treatment of cough during the study period, unless they become clinically indicated in which case a rescue regimen can be administered and the child will be withdrawn from the study * parents/legal tutors must be willing to comply with the study protocol exclusion criteria: * children treated with immunostimulators and immune regulating drugs during the last month before starting the study * children with immunodeficiencies or immune suppression * children with chronic diseases - pulmonary diseases, renal insufficiency, heart diseases * children treated with antibiotics, including prophylactic treatment * children being treated with systemic corticosteroids - including oral aerosol inhaler * children with potential immunosuppressive viral diseases - measles, chickenpox, rubella, infectious mononucleosis - within the last month * children who have participated in previous studies with experimental products within the last month * children with asthma or suspected diagnosis of asthma * children with bacterial diseases - pneumonia, sepsis * children with diabetes because of the high content of sugar of the study products - abo/meg-b-09 and placebo * children allergic to any study product ingredients * children/parents/legal tutors with psychological condition that may, in the investigator's opinion, adversely affect their co-operation with the study protocol - syrup administration or compilation of the diary

Keywords: pediatric children acute cough treatment syrup protective natural extracts
cognitive leisure and preclinical alzheimer's disease: exploring neural mechanisms

Conditions: Cognitive Dysfunction

Summary: the goal of this clinical trial is aims to: 1. translate and culturally adapt the cognitive leisure activity scale (clas) into chinese and conduct reliability and validity tests for the chinese version of clas. 2. investigate the correlation between cognitive leisure activity levels and cognitive function in the preclinical stage of alzheimer's disease (ad). 3. clarify the regulatory mechanisms of cognitive leisure activity levels on the neural circuits of patients in the preclinical stage of ad.

alzheimer's disease (ad), also known as senile dementia, is the most common neurodegenerative disorder characterized by progressive decline in cognitive function and behavioral impairment. it is estimated that there are approximately 9.83 million ad patients in china, with an average annual treatment cost of about $19,144 per person, accounting for 1.47% of the national gross domestic product, surpassing the global average. this not only severely affects the quality of life for elderly patients but also imposes a heavy economic and caregiving burden on families and society. due to the limitations of ad treatment and the irreversibility of its progression, early detection and intervention have become the focus of ad prevention and control efforts. increasingly, scholars propose shifting the diagnosis and intervention of ad to the preclinical stage, particularly the mild cognitive impairment (mci) phase and even earlier stages characterized by subjective cognitive decline (scd). cognitive leisure activity, as one of the potentially modifiable factors in the preclinical stage of ad, understanding its impact on cognitive function and the neural circuitry regulation mechanisms in this stage is of significant importance. this knowledge can contribute to the development of early targeted intervention measures, preventing or delaying the onset and progression of ad, and promoting healthy aging.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of mild cognitive impairment (mci) and subjective cognitive decline (scd) * age ≥ 60 years * capable of normal communication in mandarin，possesses a certain level of comprehension and judgment. exclusion criteria: * individuals with severe hearing or language impairments, or with severe physical illnesses that are unable to cooperate with the survey * individuals with pacemakers, metallic implants, cochlear implants, claustrophobia, and other contraindications for mri examination.

Keywords: alzheimer's disease cognitive leisure activity mri
evaluation of changes in consumption of drugs and substances after incarceration

Conditions: Addictions

Summary: to improve the management and risk reduction, it is essential to understand the evolution of the consumption of psychoactive substances, medicated or not in detention; it does not have at present no data on this subject. this work has as main objective to evaluate the development of substance use terms (goods and consumption practices) by the inmates between the period preceding their incarceration and their fifth month in detention.


Eligibility criteria:
inclusion criteria: * major subject * subject in the fourth or fifth month of incarceration * held about agreeing to participate in the study exclusion criteria: * patient refusing to participate * patient unable to respond to the questionnaire (major difficulties understanding of the french language)
tomography positron emission assessment of the impact of cardiac rehabilitation on coronary endothelial function in cardiac failure

Conditions: Cardiac Failure

Summary: in patients with heart failure, the drive to the effort has demonstrated its safety and its interest. patients with heart failure, endothelium-dependent peripheral vasodilatation is impaired by decreased activity of endothelial no synthase. the rehabilitation training significantly improves peripheral endothelial function, and this improvement is correlated to the increase in exercise capacity. the impact on coronary endothelial function remains poorly documented, especially in non-ischemic dilated heart disease. the main objective of this study is to investigate the effectiveness of cardiac rehabilitation on the restoration of coronary endothelial function in cardiac failure patient evaluated with tomography positron emission 15o-h2o.


Eligibility criteria:
inclusion criteria: * patients with heart failure with nonischemic dilated cardiomyopathy * class ii-iii nyha (new york heart association) * having no contra-indication to the effort * fraction ejection ≤ 40% * patient who will have cardiac rehabilitation * age over 18 years * informed consent signed * patient with a social security scheme exclusion criteria: * hypertension\> 160/90 mmhg * high cholesterol level \> 6.0 mmol / l * diabetes known and treated * active smoking * valvular heart disease, congenital or ischemic * pregnant or breastfeeding women * age \<18 years * major adult guardianship
decision making tool in supporting decision making in contralateral prophylactic mastectomy in patients with newly diagnosed breast cancer

Conditions: Anatomic Stage I Breast Cancer AJCC v8; Anatomic Stage IA Breast Cancer AJCC v8; Anatomic Stage IB Breast Cancer AJCC v8; Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage IIA Breast Cancer AJCC v8; Anatomic Stage IIB Breast Cancer AJCC v8; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IIIA Breast Cancer AJCC v8; Anatomic Stage IIIB Breast Cancer AJCC v8; Anatomic Stage IIIC Breast Cancer AJCC v8; Ductal Breast Carcinoma In Situ; Invasive Breast Carcinoma; Prognostic Stage I Breast Cancer AJCC v8; Prognostic Stage IA Breast Cancer AJCC v8; Prognostic Stage IB Breast Cancer AJCC v8; Prognostic Stage II Breast Cancer AJCC v8; Prognostic Stage IIA Breast Cancer AJCC v8; Prognostic Stage IIB Breast Cancer AJCC v8; Prognostic Stage III Breast Cancer AJCC v8; Prognostic Stage IIIA Breast Cancer AJCC v8; Prognostic Stage IIIB Breast Cancer AJCC v8; Prognostic Stage IIIC Breast Cancer AJCC v8; Sporadic Breast Carcinoma

Summary: this trial studies the acceptability and how well decision making tool works in supporting decision making in contralateral prophylactic mastectomy in patients with newly diagnosed breast cancer. decision making tool may help patients with early stage breast cancer make decisions regarding their surgical options.

primary objectives: i. an online decision support tool will be field tested that provides patients facing a decision about contralateral prophylactic breast cancer (cpm) with evidence-based information about the expected incidence of contralateral breast cancer and the life expectancy benefit of cpm. the tool will be designed for use in clinical settings and viewed jointly by the patient and physician as part of a shared decision making process around cpm. outline: patients use decision making tool during consultation with breast cancer surgeon and complete questionnaires before and after consultation.

Eligibility criteria:
inclusion criteria: * newly diagnosed ductal breast carcinoma in situ (dcis) or stage i-iii sporadic unilateral invasive breast cancer * able to speak read or write english exclusion criteria: * patients with previous breast cancer * prior history of bilateral prophylactic mastectomy * known to have a germline mutation that predisposes them to an increased risk of breast cancer (e.g. brca1/2) and/or they are considered at high risk for contralateral breast cancer on the basis of a strong family history of cancer
anosmia rehabilitation in patients post coronavirus disease (covid 19)

Conditions: Olfactory Disorder

Summary: the study will be a randomized controlled trial, involving patients with hyposmia/anosmia of onset immediately after an upper respiratory viral illness, assigned to three distinct study arms. nasal irrigations will be prescribed to all three groups (bid). in addition, one arm will receive a paper hand-out about post-viral anosmia with instructions to smell common household items (current care) and act as a control group. the second group will receive an essential oil retraining kit, whereas the third group will receive the same olfactory training kit and a prescription to use budesonide with the nasal irrigations. olfactory scores will be tested at the enrollment, 3 months and at 6 months.


Eligibility criteria:
inclusion criteria: * adults 18 years of age or older * hyposmia/anosmia of onset immediately after an upper respiratory viral illness confirmed on snap n' sniff threshold testing, * capable, in the opinion of the primary investigator, of providing informed consent to participate in the study. participants are required to sign an informed consent form indicating they understand the purpose and nature of the study, and that they are willing to participate. exclusion criteria: * active cigarette smoker * chronic rhinosinusitis * head trauma with loss of consciousness * inability to read/understand english * previous hyposmia/anosmia complaint * pregnancy * previous sinus * skull base or brain surgery * current participation in another clinical trial at the time of initial visit

Keywords: anosmia hyposmia covid19 post-viral anosmia snap and sniff olfactory test budesonide
safety and effectiveness of ticagrelor in patients undergoing carotid stenting

Conditions: Carotid Stenosis

Summary: patients undergoing carotid stenting take dual anti platelet therapy to prevent thrombotic complications usually used drugs are aspirin plus clopidogrel but there are patients not respond so ticagrelor may be an effective and safe alternative


Eligibility criteria:
inclusion criteria: 1. ischemis stroke of both sex. 2. more than 18 years. 3. accepting all study requirements. exclusion criteria: 1. refuse to comply with all study requirements. 2. bleeding tendency or liver diseases
role of neutrophil cd64 and monocyte hla-dr markers in the dignosis of neonatal sepsis

Conditions: Neonatal Sepsis

Summary: neonatal septicemia remains one of the main causes of neonatal morbidity and mortality . sepsis which is caused by a dysregulated host response to an infectious trigger leading to a life threatening organ dysfunction was declared by the world health organization (who) on may 2017 as a global health priority that requires resolution for its prevention , dignosis , and management (monneret et al., 2019). despite the advances in perinatal and neonatal sepsis remains high and the outcome is still sever (chirio et al.,2011) . hla-dr is on the surface of monocyte \\ macrophages , dendritic cells, and b cells and plays a crucial role in adaptive immune response , more than 30 years ago , researches proved an association between the low level of hla-dr and the development of sepsis (cheadle at al .,1991) . a decreased expression of mhla-dr molecules has been associated with immunoparalysis , which is an inflammatory immune responce that occurs in sepsis .(pradhan et al.,2016).


Eligibility criteria:
inclusion criteria: * neonates of both sexes included in this study with any suspected case of neonatal sepsis with maternal risk factors for sepsis , e.g., prolonged labor , premature rupture of membrane (prom) , maternal intrapartum fever and chorioamnionitis , and neonates with sepsis-related clinical signs: temperature instability, apnea , need for supplemental oxygen ,bradycardia , tachycardia , hypotension , hypoperfusion , feeding intolerance and abdominal distension , exclusion criteria: * are the adminstration of antibiotic therapy prior to admission , birth asphyxia , laboratory finding suggestive of inborn error of metabolism , and congenital anomalies including congenital heart diseases .
effect of self management program on clinical status of copd patients

Conditions: COPD

Summary: this study evaluates the effectiveness of self management programs based on 5a model on the lung function status, dyspnea and exercise tolerance in chronic obstructive pulmonary disease patients. participants were randomly assigned to an intervention group or a control group. the control group were receiving standard practice care and the intervention group were receiving intervention in addition to standard practice care. the intervention content include implementation of a self management plan based on 5a model.

5 a model implemented during a period of 12 weeks including 5 stags: assessment of behavior, beliefs and motivation of the patient (assess); provide information about personal health risks and benefits of change (advise); mutual contribution of patients and health care provider on setting realistic goals based on the patient's interest and confidence in their ability to change the behavior (agree); help anticipate barriers and develop practical applications based on the identified patient's strategies, problem-solving techniques and social/environmental support (assist) and specify plan for follow-up (visits, phone calls) and providing support in the course of follow up (arrange).

Eligibility criteria:
inclusion criteria: * certified diagnosis of copd with moderate or severe level by a pulmonologist according to gold criteria * age range of 45-70 years * bmi\<30 * being literate * having a strong understanding of the persian language * having a constant prescription drug regime * not suffering from another serious and restrictive disease (such as major psychological disorder, neural disease, musca-skeletal disease, cancer, cardiac or angina attack in last month) exclusion criteria: * hospitalization during the intervention * need to use of oxygen or spray during 6-minute walking test * dealing with serious stress * failure of patient to attend personal or group education session * non-compliance with a practical program that was determined at monthly visits for intervention group

Keywords: chronic lung disease
development of training programs for nursing competency reinforcement to spread trauma intervention

Conditions: Nurses Who Work at the Community Mental Health Welfare Center

Summary: this study aims to improve the trauma intervention competency of nurses through online-based training of the nursing intervention program for trauma-experienced subjects. the specific goals are as follows. 1. based on swanson's caring theory, develop an online training program for nurses to spread trauma nursing intervention and improve competency. 2. evaluate the effects of the developed program's workbook and online training on nurses' trauma-related knowledge and attitude, self-efficacy, and professional quality of life. of the 42 subjects who enrolled in the study, 1 dropped out before intervention, resulting in 41 participants who completed all interventions and surveys.


Eligibility criteria:
inclusion criteria: * those who have a nurse's license * those who work at the mental health welfare center * those who can access the program through a computer or mobile * those who understand the purpose of the research and voluntarily agree to participate in the research exclusion criteria: - those who do not agree to participate in the study
effect of three non-drug intervention in treatment of children with overweight

Conditions: Obesity

Summary: the purpose of this study is to compare the effect of three different non-pharmacological interventions (usually practiced in ambulatory care of childhood obesity (amo), physical activity program (ifsp) and diet therapy adjusted estimate by indirect calorimetry) on the percentage of body fat and basal metabolism of children and overweight and obesity in the metropolitan region of porto alegre (rs).


Eligibility criteria:
inclusion criteria: * age 8 to 15 years old with overweight (z-score bmi +1 e +2) and obesity (z-score bmi \> +2) exclusion criteria: * chronic diseases

Keywords: obesity
study to assess the safety and immunogenicity of monovalent mrna na vaccine in adult participants 18 years of age and older

Conditions: Influenza Immunization; Healthy Volunteers

Summary: this is a phase i, first-in-human, randomized, modified double-blind, active-controlled, dose-escalation study to assess the safety and immunogenicity of up to 3 dose levels of mrna na vaccines, administered as a single im injection in healthy adults aged 18 years and older. two age groups, 18 to 64 years and ≥65 years, will be included in this study.

this study will include a screening visit, 6 study visits occurring on days 1, 3, 9, 29, 91, and 181, and a safety follow-up telephone call on day 366.

Eligibility criteria:
inclusion criteria: * aged 18 years or older on the day of inclusion. * a female participant is eligible to participate if she is not pregnant or breastfeeding and one of the following conditions applies: 1. is of non-childbearing potential. to be considered of non-childbearing potential, a female must be postmenopausal for at least 1 year, or surgically sterile or 2. is of childbearing potential and agrees to use an effective contraceptive method or abstinence from at least 4 weeks prior to study intervention administration until at least 12 weeks after study intervention administration * a female participant of childbearing potential must have a negative highly sensitive pregnancy test (urine or serum as required by local regulation) within 8 hours before administration of study intervention. * informed consent form has been signed and dated. exclusion criteria: * known or suspected congenital or acquired immunodeficiency; or receipt of immunosuppressive therapy, such as anti-cancer chemotherapy or radiation therapy, within the preceding 6 months; or long-term systemic corticosteroid therapy (prednisone or equivalent for more than 2 consecutive weeks within the past 3 months). * known systemic hypersensitivity to any of the study intervention components; history of a life-threatening reaction to the study interventions used in the study or to a product containing any of the same substances * moderate or severe acute illness/infection (according to investigator judgement) or febrile illness (temperature ≥100.4°f) on the day of study intervention administration. * have known or recently active (12 months) neoplastic disease or a history of any hematologic malignancy. * have any diagnosis, current or past, of autoimmune disease. * body mass index of 40 kg/m2 or higher. * receipt of immune globulins, blood, or blood-derived products in the past 3 months. * have taken high-dose inhaled corticosteroid (≥500 μg of fluticasone) within 6 months prior to study vaccination. * self-reported or documented seropositivity for hiv, hepatitis b virus, or hepatitis c virus.
mobile health (mhealth) black women with breast cancer

Conditions: Breast Neoplasms

Summary: this research study will test whether a series of video clips with breast cancer information improves knowledge of breast cancer, breast cancer treatment and living with breast cancer. questionnaires will be completed to learn if the videos are helpful and pleasant to watch.

though black women have a lower breast cancer rate than white women, black women have the poorest outcomes of all races and ethnicities. low cancer knowledge and mistrust of the healthcare system have been shown to lead to poorer outcomes following breast cancer diagnosis. participants are asked to be in this research study if they are a woman age 21 years or older who identifies as black/ african american and has been diagnosed with breast cancer within the past 6 months. first, participants will come to a pre-intervention study appointment and will be asked to complete several questionnaires. the questionnaires will ask about breast cancer knowledge, quality of life, and their relationship with their doctor. participants will then opt-in to the study by sending a text message to the study. for the next ten ten weeks, participants will receive a text message with a link to one video clip per week. each video is 15-20 minutes long and contains information about breast cancer. participants will also receive one supportive text message per week for ten weeks. at the end of the ten weeks, participants will be scheduled for a follow-up appointment. participants will again be asked questions about breast cancer knowledge, quality of life, and their relationship with their doctor. participants will also be asked what was helpful and not helpful about the videos.

Eligibility criteria:
inclusion criteria: * age: 21 years or older * race/ethnicity: black from any cultural background (e.g., african american, caribbean islander, haitian, black hispanic, etc.) * diagnosed with breast cancer stages 0-iii in the past 6 months * life expectancy: ≥12 months * income: at or below 200% of the federal poverty line * have access to a cellphone * able to receive text messages on cell phone * able to view video clips on cell phone. exclusion criteria: * previous diagnosis of any type of cancer * conditions or behaviors likely to affect the conduct of the trial: unwilling or unable to give informed consent; unable to understand spoken english at the 8th grade level; unwilling to travel to university of florida health shands hospital or healthstreet for baseline and follow-up assessment appointments; inpatient psychiatric treatment for major psychiatric disorder in the past year; substance use disorder in the past year; and other conditions which in the opinion of study staff would adversely affect participation in the trial.
comparison of a minimally invasive technique for total knee replacement to a standard technique

Conditions: Osteoarthritis

Summary: comparison of a minimally invasive technique for total knee replacement to a standard technique


Eligibility criteria:
inclusion criteria: * no inflammatory arthritis, * no other lower limb problem, * no major comorbidity exclusion criteria: -