Kornimate/medical-research-clean huggingface dataset:
dietary fiber and hyperkalemia in dialysis patients

Conditions: Hyperkalemia; Hemolysis

Summary: to analyze the dietary nutrition and dietary fiber (df) intake of maintenance hemodialysis (mhd) patients, and explore the effect of dietary nutrition and df intake balance on the nutritional status and pre-dialysis hyperkalemia of mhd patients.

a total of 100 mhd patients were retrospectively enrolled, including 67 males and 33 females. the daily diet was recorded by 3-day dietary recording method. the daily average dietary nutritional intake and df intake of mhd patients were calculated by professional software. dietary guidance and analysis were conducted according to the expert consensus on nutrition in chronic kidney disease (2005) and the dietary guidelines for chinese residents (2016). of the 100 patients, 37 had hyperkalemia (serum potassium \> 5.5 mmol/l) before dialysis.

Eligibility criteria:
inclusion criteria: * 18-65 years old; undergoing hemodialysis at least 3months; with a certain level of education; with complete behavioral ability exclusion criteria: * in the acute phase of acute cardiovascular disease, acute cerebrovascular disease, and acute digestive system disease；anorexia, long-term malnutrition, or dietary disorders；poor compliance；
suicide attempts and tramadol : a case report

Conditions: Suicide, Attempted; Addiction

Summary: in france, over the last years the use weak opioid analgesics decreased́, whereas that of strong opioid analgesics (ofma). hospitalizations for opioid overdose increased́ by 128% from 2000 to 2015, and deaths related to prescribed opioid overdose increased significantly, by 161%, from 2000 to 2014.in addition, recent studies suggest a link between opioid system dysfunction and suicidal behavior. in parallel, studies are emerging showing the potential interest of using tramadol as an antidepressant. indeed, this opiate analgesic also acts on the serotonergic and dopaminergic systems, and would have an antidepressant effect.thus, the investigators can legitimately wonder whether the use of tramadol as an antidepressant might not pose a problem in patients at risk of suicide. this study aims to describe a clinical case of a patient hospitalized in the department of psychiatric emergency and post-emergency (montpellier university hospital) who developed a severe addiction to tramadol (consumption up to 5 times the maximum recommended dose per day) and evaluate whether this may have increased her suicidal risk, in order to warn prescribers about the suicidal risk of tramadol.


Eligibility criteria:
inclusion criteria: * multiple suicide attempts * tramadol addiction na : patient case report exclusion criteria: - none

Keywords: suicide addiction opioids
genomic landscape of ceritinib

Conditions: Carcinoma, Non-Small-Cell Lung; Non-small Lung Cancer; Non-Small Cell Lung Cancer

Summary: the investigators propose to conduct a retrospective study of single agent ceritinib in patients with previously untreated anaplastic lymphoma kinase (alk) rearranged adenocarcinoma of the lung with the sole purpose of characterizing the genomic landscape before ceritinib and at the time of disease progression.

further improvements in therapy can only be achieved with a better understanding of the genomic landscape of alk rearranged non-small cell lung cancer (nsclc), specifically at the time of disease progression following treatment with alk inhibitors. recently, secondary alk mutations, l1196m and g1269a have been described in patients with acquired resistance to crizotinib. a small subset of alk positive lung cancer patients who progressed after treatment with ceritinib had tumors available for molecular analysis. secondary mutations found included g1202r, f1174c, and f1174v. while this is interesting, an unbiased genomic study (exome or whole genome sequencing) using massively parallel sequencing at the time of disease progression is critical to fully understand the clonal evolution and the molecular mechanisms underpinning treatment resistance. to the best of the investigators' knowledge, such a study has not yet been reported. the investigators believe the time is ripe now to comprehensively characterize genomic alterations using massively parallel sequencing technology of alk driven adenocarcinoma of the lung to fully understand the clonal heterogeneity before therapy and fully understand the clonal evolution and the molecular mechanisms underpinning treatment resistance. a better understanding of genomic alterations through an unbiased comprehensive approach likely would lead to rationally designed therapy to augment response to alk inhibitors.

Eligibility criteria:
inclusion criteria * diagnosis of metastatic stage iiib/iv lung adenocarcinoma. * presence of known alk gene rearrangement. * consented to hrpo# 201305031 ("tissue and blood acquisition for genomic analysis and collection of health information from patients with thoracic malignancies, suspected thoracic malignancies, or mesothelioma") with an existing specimen prior to initiation of treatment with ceritinib. * at least 18 years of age. * received treatment with standard of care ceritinib
hypobaric flight simulation in copd patients

Conditions: COPD; Hypoxia; Aviation

Summary: aim of this study was to evaluate the hypoxic response during hypobaric flight simulation in normal individuals as well as in normocapnic and hypercapnic copd patients as well as to evaluate the impact of a flight simulation on walking endurance in these patients.

background and aim: commercial aircrafts have their altitude compensation adjusted to 2500 meter above sea level which corresponds to a pressure difference of about 270 hpa. this causes a reduction of the partial pressure of oxygen during the flight. patients with lung disease are especially challenged by large walking distances within airports and during their journey. the objective of our study is to evaluate the impact of a simulated flight under hyperbaric conditions on walking endurance in healthy individuals as well as in copd patients with and without hypercapnia. method: healthy individuals as well as copd patients were assessed pre-flight with the following measurements: 1. arterial blood gas analysis 2. lung function test 3. lung diffusion test 4. hemoglobin level 5. six minute walking distance during the flight measurements included (measured every 30 minutes until landing): 1. heartrate 2. oxygen saturation 3. borg scale post flight measurements included: 1. arterial blood gas analysis 2. six minute walking distance intended analysis: * description of endurance response as a function of copd disease severity. * description of endurance response in normocapnic and hypercapnic copd patients. * detection of pre-flight predictors that determine flight tolerability and hypoxic response.

Eligibility criteria:
inclusion criteria: * no lung disease * copd without hypercapnea * copd with hypercapnea exclusion criteria: * claustrophobia * renal insufficiency * heart failure (ejection fraction \< 45 %)
cryotherapy vs. nitric-zinc complex in the treatment of plantar warts.

Conditions: Plantar Wart

Summary: plantar warts are benign skin lesions caused by human papillomavirus (hpv).there are several treatment methods for this illness, but none of them can heal all patients. cryotherapy using liquid nitrogen is one of the most common local treatments. in this study, we will compare the effectiveness of cryotherapy with liquid nitrogen with the association of organic acids and nitric acid (nitric-zinc complex). in addition, as secondary objectives have been defined: 1) know the number of applications necessary for each treatment to achieve the complete resolution of the plantar wart, in order to compare the healing times between each treatment and establish which treatment is faster, 2) analyze the influence of the hpv biotype, the location of the lesion and the time of evolution in the response to the different treatments, and 3) compare the ultrasound signs of plantar warts with the ultrasound signs of healthy skin after the resolution of the process.

a randomized controlled clinical trial is proposed. the recruitment of patients will be carried out by including the sample of those patients who have diagnostic confirmation of plantar wart in the chiropodology and surgery service of the university podiatry clinic of the complutense university of madrid, consecutively, between november 2020 and the date when the estimated sample size is reached. participants in the trial will be assigned with equal probability to each treatment arm, based on their consecutive inclusion in the study. subsequently, the treatment allocation will be determined by a random code generated by the epidat 4.1 program using random permuted blocks. the treatment used will be evident both for the participant and for the research podiatrist responsible for the intervention. however, the primary result will be confirmed by the microbiological study carried out by the department of microbiology of the complutense university of madrid, which does not know any data about the patient or the treatment group to which it was initially assigned.

Eligibility criteria:
inclusion criteria: * subjects older than 12 years. * patients diagnosed with recalcitrant or non-recalcitrant plantar wart. exclusion criteria: * diagnosis of diabetes mellitus. * peripheral vascular disease. * patients with an immune system disorder or in immunosuppressants treatment. * peripheral or central neuropathy. * coagulation disorders. * raynaud's disease or some alteration of the perception of cold or heat. * alterations in healing for wounds or in the synthesis of collagen.

Keywords: plantar wart nitric acid cryotherapy
effectiveness of a telehealth postural awareness program combined with exercise in people with neck pain

Conditions: Neck Pain

Summary: people with neck pain often experience pain, neck disability, and poor quality of life. postural-based awareness programs are evidence-based interventions for postural problems and neck pain disorders. this study aims to determine the effectiveness of a telehealth physiotherapist-delivered postural awareness program combined with exercise in people with neck pain. pain, neck disability, leisure time management, and exercise stage of change were evaluated.

pain with visual analog scale, neck disability with neck disability index, leisure time management with leisure time management scale, and exercise stage of change with exercise stage of change scale were determined. the authors aim to find out if there are any changes before and after the program on the pain, neck disability, and evaluation subscale of the leisure time management scale, and exercise stage of change of participants.

Eligibility criteria:
inclusion criteria: * being aged 18 years or over, * volunteering to take part in the study, * being a student of online education, * without a history of any neurological or orthopedic problem, * with resting neck pain (as measured by the vas) lasting ≤30 days * that is aggravated by movement without extending distal to the shoulders. exclusion criteria: * rheumatological diseases, malignity or structural deformities, * previous surgical intervention related to the neck region, * severe pain (more than 7 in 0 to 10 vas)

Keywords: neck pain neck telehealth awareness posture exercise
ahsct combined with car-t cells in the treatment of refractory and relapsed multiple myeloma

Conditions: Multiple Myeloma

Summary: clinical study on the safety and effectiveness of autologous hematopoietic stem cell transplantation combined with car-t cells in the treatment of refractory and relapsed multiple myeloma

this is a prospectiv , single arm, open-label, single-center study. this study is indicated for refractory and relapsed multiple myeloma. it aims to evaluate the safety and effectiveness of autologous hematopoietic stem cell transplantation combined with bcma car-t to treat refractory and relapsed multiple myeloma. the main research is completely alleviated, overall reaction rate, and recurrence rate,etc. 50 patients will be enrolled.

Eligibility criteria:
inclusion criteria: * 1、bcma positive accompanied by refractory/relapsed and resistance; * 2、patients with the tumor load is high and cannot be transplanted directly, before transplantation. reduce the load through car-t treatment to prepare for transplantation; * 3、patient relapses after transplantation,donor lymphocyte infusion invalid. the donor cells in the recipient body can be used or the donor cells can be collected directly.prepare car-t to prevent recurrence and induce relapsing; * 4、repeated mrd (+) refractory drug resistant cases; * 5、male or female, 30-75 years old; * 6、anticipated survival time more than 12 weeks * 7、transplant subjects, regardless of their previous treatment, are eligible for inclusion after relapse； * 8、patients had a negative urine pregnancy test before the start of administration and agreed to take effective contraceptive measures during the test period until the last follow-up; * 9、those who voluntarily participate in the trial and sign the informed consent form exclusion criteria: * 1、patients with the history of epilepsy or other cns disease； * 2、patients with prolonged qt interval time or severe heart disease； * 3、pregnant or breastfeeding; * 4、active infection with no cure; * 5、patients with active hepatitis b or c infection; * 6、previously treated with any genetic therapy; * 7、the proiferation rate is less than 5 times response to cd3/cd28 co-stimulation signal; * 8、serum creatinine \> 2.5mg/dl or alt / ast \> 3 times uln or bilirubin \> 2.0mg/dl; * 9、those who suffer from other uncontrolled diseases are not suitable to join the study; * 10、hiv infection; * 11、any situation that the researchers believe may increase the risk of patients or interfere with the test results.

Keywords: ahsct bcma car-t
formal pre-operative education

Conditions: Upper Extremity Orthopedic Surgery Patients

Summary: the investigators want to determine if delivering formal preoperative education to patients helps the patients with post operative pain, function and overall satisfaction. education would cover surgery, post operative activities of daily living, pain and edema management, duration of recovery and any expected therapy they might need. all participants will receive a pre and post operative questionnaire to determine level of understanding of anticipated needs and barriers due to surgery. group one will receive formal education from an occupational therapist or physical therapist while group two will receive only standard education in the md clinic.


Eligibility criteria:
inclusion criteria: * 18 years or older, * english as primary language, * scheduled to have orthopedic upper extremity surgery. exclusion criteria: * less than 18 years * conservative management or non operative management of orthopedic upper extremity surgery
a phase 2 study to learn about a monovalent pneumococcal conjugate candidate in healthy toddlers

Conditions: Healthy Participants

Summary: the purpose of the study is to learn about the effects of a monovalent (single component) pneumococcal conjugate candidate (mpnc candidate) when given to toddlers between 11 and 15 months of age. all participants in this study will receive 2 doses of either mpnc candidate or mpnc control at the clinic approximately 8 weeks apart. all participants will also receive their third (toddler) dose of pcv10 at visit 1.


Eligibility criteria:
key inclusion criteria: * toddlers ≥11 to ≤15 months of age at the time of consent. * have received exactly 2 infant doses of pcv10 according to a local immunization schedule. * healthy toddlers determined by clinical assessment, including medical history and clinical judgment, to be eligible for the study. key exclusion criteria: * history of severe adverse reaction associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis) to any component of study intervention, 13vpnc, 20vpnc, or any diphtheria toxoid-containing vaccine. * significant neurological disorder or history of seizure (excluding febrile seizure) or significant stable or evolving disorders such as cerebral palsy, encephalopathy, hydrocephalus, or other significant disorders. * major known congenital malformation or serious chronic disorder. * history of microbiologically proven invasive disease caused by s pneumoniae. * previous vaccination with any licensed pneumococcal vaccine (other than the pcv10 primary infant series) or investigational pneumococcal vaccine, or planned receipt of nonstudy pneumococcal vaccine during study participation.

Keywords: pneumococcal disease
effect of 8.5 f plastic stent without proximal flap on prevention of post-ercp cholangitis

Conditions: Cholangitis; Complication

Summary: cholangitis is one of the main complications of endoscopic retrograde cholangiopancreatography (ercp). plastic biliary stent was used to prevent the occurrence of post-ercp cholangitis, but the stent should be taken out 1-2 weeks after ercp with endoscope again. 8.5 f plastic stent with proximal flap can discharge self-driven from biliary to the gut, it has the advantage of avoiding pulling stent out with endoscope again. the purpose of this study is to explore 8.5 f plastic stent with proximal flap on preventing post-ercp cholangitis of ercp in patients with choledocholithiasis.

since its introduction in 1968, endoscopic retrograde cholangiopancreatography (ercp) has become a commonly performed endoscopic procedure, and the first choice in the management of choledocholithiasis. although as an endoscopic minimally invasive procedure, there are still certain complications of ercp, cholangitis is one of the main complications. in european and american countries, plastic biliary stent was used to prevent the occurrence of post-ercp cholangitis, but the stent should be taken out 1-2 weeks after ercp with endoscope again. in china endoscopic nasobiliary drainage is usually adopted to prevent post-ercp cholangitis. although nose bile duct was more convenient to pull out without endoscope again, but patients often feel nose pharynx ministry unwell obviously. 8.5 f plastic stent with proximal flap can discharge self-driven from biliary to the gut, it has the advantage of avoiding pulling stent out with endoscope again. the purpose of this study is to explore 8.5 f plastic stent with proximal flap on preventing post-ercp cholangitis of ercp in patients with choledocholithiasis.

Eligibility criteria:
inclusion criteria: obtention of a written informed consent; patient with choledocholithiasis; common bile duct stones are removed clearlly. exclusion criteria: no written informed consent; combined with acute pancreatitis, acute cholangitis pre-ercp; patient under 18 or over 75 years.

Keywords: cholangitis endoscopic retrograde cholangiopancreatography complication
treatment of influenza and arvi in children by kagocel ®

Conditions: Influenza; Acute Upper Respiratory Infection

Summary: this study examined the etiology of acute respiratory viral infections (arvi) during the 2015-2016 season, evaluated the statistics of the incidence of influenza and arvi in this period (epidemiology: severity of the disease and bacterial exacerbations; demographics of patients; duration and timing of treatment; safety; quality of treatment), and evaluated the effectiveness of complex therapy with an emphasis on the using of interferon inducers in hospitalized children aged 3 to 11 years.

this non-interventional observational study included 80 patients aged 3 to 11 years who were hospitalized with influenza and acute respiratory viral infections (arvi) symptoms at any time from the onset of the disease (up to 15 days) and who were prescribed the interferon inducer kagocel as an antiviral medicine. the diagnosis of influenza and arvi was confirmed in accordance with the world health organization (who) guidelines for the pharmacological treatment of pandemic influenza a (h1n1) 2009 and other influenza viruses. all patient examinations are conducted in accordance with local routine clinical practice and local and international standards of care. after the end of treatment, the following data were collected and analyzed: * demography * disease severity * anamnesis data (data of influenza vaccination in the current season; pre-school facilities visits; previous contacts with a patient with influenza / arvi; previous antiviral therapy for the current episode of the disease; concomitant diseases) * body temperature (morning/evening) * chills and fever (cumulative score based on all symptoms: 0-no symptoms, 1-mild, 2-moderate, 3-severe) * intoxication symptom (cumulative score based on all symptoms: 0-no symptoms, 1-mild, 2-moderate, 3-severe) * catarrhal symptoms (cumulative score based on all symptoms: 0 - no symptoms, 1-mild, 2-moderate, 3-severe) * timelines: the beginning of the disease, the first visit to the doctor, the beginning of treatment, the duration of the disease * determination the causative agent by pcr (on presentation of patients and their discharge on 5-6 days from start of therapy) * antiviral therapy (kagocel dose depending on age) * symptomatic treatment of the current episode of influenza or arvi before and during the patient's hospitalization * bacterial exacerbations (yes/no) * treatment of bacterial exacerbations (drug name) * adverse events

Eligibility criteria:
inclusion criteria: 1. the patient's age from 3 to 11 years inclusive. 2. the patient was hospitalized with symptoms of influenza and arvi. 3. the appointment of drug kagocel ® as an antiviral therapy of influenza or arvi by the doctor during hospitalization 4. no history of allergy and / or hypersensitivity to the components of the drug kagocel ® . 5. signed informed consent to participate in the study. exclusion criteria: - patients who received antiviral and immunomodulatory medications within 15 days prior to hospitalization

Keywords: influenza flu acute respiratory viral infection arvi acute upper respiratory infection auri
pilot 99mtechnetium-mibi single photon emission computed tomography - computed tomography (spect-ct) in papillary carcinoma (ca) thyroid

Conditions: Papillary Thyroid Cancer

Summary: the purpose of this trial is to see if the 99mtechnetium-mibi spect-ct can be a tool for preoperative evaluation of cervical node metastasis in papillary thyroid cancer.


Eligibility criteria:
inclusion criteria: * papillary thyroid cancer exclusion criteria: * pregnancy * bleeding abnormality * prior history of head and neck cancer * can not perform 99mtechnetium-mibi spect-ct * can not perform 131i remnant ablation * prior any head and neck surgery within 3 months * prior deep neck infection within 3 months

Keywords: papillary thyroid cancer 99mtechnetium mibi spect ct preoperative cervical lymphadenopathy cervical metastasis