Kornimate/medical-research-clean huggingface dataset:
treatment of follicular lymphoma with high dose therapy and stem cell support followed by rituximab and alpha interferon

Conditions: Follicular Lymphoma

Summary: this is a non-comparative, prospective, non-randomized single centre phase ii clinical trial of rituximab and alpha interferon immunotherapy following autologous stem cell transplant in patients with relapsed follicular lymphoma conducted at toronto sunnybrook regional cancer centre/sunnybrook and women's health sciences centre.


Eligibility criteria:
inclusion criteria: * patients with 1-2 relapses of who classification follicle centre nhl grade 1-2/3. patients must have achieved at least a pr to previous treatment. * central pathology review before registration * ann arbor stage iii or iv * measurable disease: defined as clinically or radiologically documented disease with at least one site bidimensionally measurable using clinical exam, ct or mri performed in the 3 weeks prior to study enrollment. * ecog performance status of \<2. * patients may have received not more than 1 prior course (4 infusions) of rituximab. timing of rituximab must exceed 12 months prior to registration. patients must have demonstrated at least a pr to rituximab if previously administered. * patient consent according to institutional and university human experimentation committee requirements * adequate renal, hepatic and hematopoietic function test unless the abnormal values are thought to be due to involvement with lymphoma as defined by: hb\> 85 anc \>1000/mm3 platelets \>100,000/mm3 serum/total bilirubin \>=2 si units ast/alt \<2x upper limit of normal exclusion criteria: * positive serology for hiv * uncontrolled infection * pregnancy * cns metastases * history of psychiatric disorder * other malignancy (except nonmelanoma skin cancer) * serious non-malignant disease (e.g., congestive heart failure, or active uncontrolled bacterial, viral, or fungal infections), or other conditions, which, in the opinion of the investigator and/or the sponsor, would compromise other protocol objectives. * major surgery, other than diagnostic surgery, within four weeks. * presence of anti-murine antibody (hama) reactivity. these laboratory results must be available prior to receiving treatment for those patients * who have received prior murine proteins or patients who have allergies to murine proteins. * new york heart association class iii or iv heart disease (see appendix h, clinical evaluation of functional capacity of patients with heart disease in relation to ordinary physical activity) or myocardial infarction within the past six months. * treatment with an investigational drug within 30 days or five half-lives (of the study drug with the longest half-life) prior to entry into the study, which ever is longer. * previous chemotherapy, immunotherapy, radiotherapy, or investigational therapy for the treatment of other malignancy except basal cell or squamous cell skin cancer or carcinoma in situ of the cervix within the last 5 years. * history of allergic reactions to compounds chemically related to rituximab. * refusal to practice contraception if of reproductive potential.
coccygeal nerve radiofrequency treatment in coccydynia

Conditions: Coccyx Disorder

Summary: coccydynia or coccygeal pain is a painful syndrome that affects the coccyx region. the most important etiological factors in the formation of coccidynia are; external and internal trauma. patients with coccydynia typically complain of coccyx pain. this pain increases with prolonged sitting, bending backwards during sitting, standing for long periods of time, and standing up after sitting. conservative treatments such as nonsteroidal anti-inflammatory drugs (nsaids), levator sudden relaxation exercises, seat cushions, and transcutaneous electrical simulation have all been used to relieve pain, but these methods are ineffective in 10% of patients. in the patient group unresponsive to conservative treatments, there are various interventional treatment options, including caudal epidural steroid injection, ganglion impar blocks, radiofrequency ablation of the sacral nerves, block of the coccygeal nerves and radiofrequency ablation, and coccygectomy.

in algoloji clinic, routinely apply ultrasound-guided coccygeal nerve block and radiofrequency ablation to patients with coccydynia. during the procedure, after imaging the sacral and coccygeal corns with ultrasonography, a radiofrequency ablation needle is inserted at the level of the coccygeal horn and radiofrequency ablation is applied at 90 degrees for 60 seconds. patients are followed for a while in our post-procedure service for possible hypotension and allergic reactions. in this study, it was planned to apply the visual pain scale (vas) and paris functional coccydynia questionnaire at the 1st week, 1st month and 3rd months after the treatment to patients who had coccygeal nerve block and radiofrequency ablation in our clinic due to the complaint of coccydynia resistant to conservative treatment methods. in this way, it is planned to evaluate the efficacy of treatment.

Eligibility criteria:
inclusion criteria: * coccygeal pain exclusion criteria: * malignancy * i̇nfection * coagulation disorders

Keywords: coccydinia coccygeal nerve radiofrequency ablation
new triple hop test quality assessment tool

Conditions: ACL Injury

Summary: this study will develop a new jump assessment tool for the triple hop test, and will test its reliability on adolescent and adult, healthy and post- anterior cruciate ligament (acl) population. creating a new assessment test for a jump test that incorporates the known movement components that are important after an acl injury can improve patient evaluation, decision for return to sport activity and injury prevention.

study population- adults, women and men aged 20-45, boys and girls aged 12-15. uninjured population: non symptomatic subjects, without major injury in their history. injured population: acl injured subjects, 9-12 month after beginning of treatment/surgery. stages of study: stage 1- the investigators will create a new high-quality literature-based assessment test for the triple hop test (ntht). the test will have 10 sections, its score ranges from 0 to 14 points and a high score means poor performance. stage 2- performing reliability tests between and within the testers for ntht. the tests will be done with the help of video photography of ntht. stage 3- performing ntht and tht tests on healthy adult and adolescent subjects and on acl adult and adolescent subjects, assessing the ntht by watching video performance.

Eligibility criteria:
inclusion criteria uninjured population: * non symptomatic subjects * without major injury in their history. inclusion criteria injured population: * acl injured subjects * 9-12 month after beginning of treatment/surgery. exclusion criteria uninjured population: * acute pain * knee instability symptoms * history of lower leg injury * unable to jump on one leg * knee ligament injury. exclusion criteria injured population: * late in rehabilitation program * unable to jump or run * instability symptoms.
the cartagena cohort study

Conditions: Cardiovascular Diseases; COPD; Lung Function Decreased; Atherosclerosis

Summary: cardiovascular and respiratory diseases are the first and third cause of death, respectively. cardiovascular risk is known to increase in groups with impaired lung function; however, the mechanisms behind this association are not fully understood. the aim of cares is to elucidate the shared pathophysiology of impaired lung function and cardiovascular risk, and to investigate the risk factors associated with them. the cares cohort study includes adults (18-80 years old) from cartagena de indias, a tropical city on colombian caribbean coast, where recent population admixture settled a three-hybrid genetic structure (european, african and ameridian ancestry). at baseline, the cohort will generate extensive data on -omics (e.g., genomics, transcriptomics, metabolomics, and epigenomics), socio-economic wellbeing, lifestyle, medical history, cardiometabolic, inflammatory and liver function markers, as well as objective measures of ventilatory and cardiovascular performance. the cohort will collect data every three years, for a total period of ten years. prospective risk of cardiovascular disease and chronic obstructive pulmonary disease (copd) will be investigated, and their risk factors. throughout the study period, changes in prevalence, and interactions of various risk factors with these changes will also be ascertained. a predictive risk score for cardiovascular and chronic respiratory disability will be built, using cross-sectional and longitudinal data.


Eligibility criteria:
inclusion criteria: * adults * native from colombian caribbean coast exclusion criteria: * pregnant women * walking physical disability * cognitive disability * patients under treatment for any type of cancer * clinical record of primary chronic endocrine disease * clinical record of major respiratory tract surgery

Keywords: low and middle income countries non-communicable diseases latin america cardio-respiratory disease
development of a novel hiv risk reduction intervention for abused women

Conditions: Sexual Behavior

Summary: the purpose of this study is to develop and evaluate an hiv risk reduction intervention for women with a history of abuse.

the purpose of the proposed research is to pilot test an innovative, theoretically-guided sexual risk reduction intervention for women with a history of abuse. t intervention builds on previous findings suggesting that it is important to address the psychological consequences of abuse, as well as the typical antecedents of sexual risk behavior. to inform intervention development, women who reported a history of abuse were recruited to participate in key informant interviews. based on interview findings and guided by theory and empirical precedent, a novel sexual risk reduction intervention was developed and refined. the intervention will be pilot tested with 80 women recruited from a publicly-funded clinic who report a history of abuse and current sexual risk behavior. these women will complete a computerized survey to assess abuse, adult sexual risk behavior, hiv-related information, safer sex motivation, behavioral skills, interpersonal trust, guilt, and powerlessness. behavioral skills will also be assessed through role-plays and simulation scenarios. women will be randomly assigned to the novel intervention or to a structurally equivalent intervention focused only on the psychological antecedents of sexual risk behavior. three months after intervention completion, women will return to complete computerized interviews and behavioral skills assessments. the long-term goal of this research is to develop a feasible and effective sexual risk reduction intervention for women who have a history of abuse.

Eligibility criteria:
inclusion criteria: * history of abuse * current sexual risk behavior exclusion criteria: * less than age 18 * impaired mentally * do not speak english * severely depressed or suicidal * hiv+

Keywords: abuse sexual behavior sexual risk reduction behavioral intervention
computer-based classification of colorectal polyps using narrow-band imaging

Conditions: Colorectal Polyps

Summary: recent studies have shown that narrow-band imaging (nbi) is a powerful diagnostic tool for the differentiation between neoplastic and non-neoplastic colorectal polyps. the aim of the present study is to develop and evaluate a computer-based method for automated classification of small colorectal polyps on the basis of vascularization features.in a prospective study 207 polyps with a size of 10mm or smaller should be detected by a zoom nbi colonoscopy. these polyps were imaged and subsequently removed for histological analysis. the polyp images were analyzed by a computer algorithm. the proposed computer-based method consists of several steps: preprocessing, vessel segmentation, feature extraction and classification. the results of the automatic classification (sensitivity, specificity, negative predictive value, positive predictive value and accuracy)were compared to those of human observers, who were blinded to the histological gold standard.


Eligibility criteria:
inclusion criteria: * all patients who did not meet the exclusion criteria were included in the study exclusion criteria: * patients with chronic inflammatory bowel disease, adenomatosis coli, coagulopathy, insufficient bowel preparation, or previous colonoscopy within the last 3 years; age under 18 years; no written informed consent for participation in the study

Keywords: small colorectal polyps narrow band imaging vascularization computer-based classification
clinical observation of ningmitai capsule in treating chronic pelvic pain syndrome with erectile dysfunction

Conditions: Chronic Prostatitis With Chronic Pelvic Pain Syndrome; Erectile Dysfunction

Summary: objective: the purpose of this study was to evaluate the clinical efficacy and safety of ningmitai capsule alone or in combination with sildenafil compared with sildenafil alone in the treatment of cp/cpps with erectile dysfunction. study design: a multicenter, prospective, randomized and positive drug-controlled clinical study design was adopted. interventions: ① western medicine group (sildenafil): sildenafil citrate, 25mg/capsule, once a night, one capsule each time, for 4 weeks. ② chinese medicine group (ningmitai capsule): ningmitai capsule, 0.38 g/capsule, 3 times a day, 4 capsules each time, taken after meals for 4 weeks continuously. ③ combination group (ningmitai capsule + sildenafil): ningmitai capsule, 0.38 g/capsule, 3 times a day, 4 capsules each time, taken after meals; sildenafil citrate, 25mg/capsule, once a night, one capsule each time, was taken continuously for 4 weeks.

sample size: 214

Eligibility criteria:
inclusion criteria: 1. male patients aged 20-50 years; 2. have a fixed sexual partner and have a normal sexual life; 3. long-term and repeated pelvic discomfort or pain (nih-cpsi pain score ≥ 4), or accompanied by lower urinary tract symptoms (micturition score \> 4), lasting more than 3 months; 4. secondary patients with erectile dysfunction after normal erection or sexual intercourse, and iief-5 ≤ 21 points; 5. it accords with the main symptoms of damp-heat stagnation syndrome in traditional chinese medicine; 6. volunteer subjects and agree to sign informed consent. exclusion criteria: 1. those who use any antibiotics, α-receptor blockers, pde5 inhibitors and androgens within one week; 2. patients with varicocele or tumors in prostate, bladder and urethra; 3. have received turp, tuip, bladder neck incision, transurethral hyperthermia/radiofrequency ablation/balloon dilatation, open prostatectomy, or any other prostate surgery and treatment, such as cryotherapy or hyperthermia; 4. patients with severe organic ed, drug-induced and traumatic ed, abnormal development of external genitalia or abnormal sex hormone level; 5. patients with severe cardiovascular and cerebrovascular diseases, liver, kidney and hematopoietic diseases and psychosis; 6. those who are known to be allergic to the drugs tested in this study or some of their components

Keywords: ningmitai capsule sildenafil chronic prostatitis/chronic pelvic pain syndrome erectile dysfunction
surgical emergencies gradation and postoperative outcome

Conditions: Emergency Surgery; Mortality

Summary: reducing surgical waiting time has been shown to be associated with a reduction in postoperative morbidity and mortality in this type of surgery. the use of a gradation of surgical emergencies makes it possible to prioritise them in an objective, consensual manner and to carry them out within a theoretical expected waiting time relative to the degree of urgency. the investigators hypothesise that exceeding the theoretical expected waiting time relative to the degree of urgency defined by the gradation of surgical emergencies is associated with an increase in postoperative morbidity and mortality in emergency surgery. the objective is to assess the impact on post-operative morbidity and mortality of waiting times exceeding the theoretical expected time by grading the surgical emergencies of patients undergoing emergency surgery.


Eligibility criteria:
inclusion criteria: * age \> 18 years old. * non-cardiac emergency surgery. exclusion criteria: * minor patients * emergency cardiac surgery * patients under guardianship or curators * pregnant women * patients who object to their personal data being used in research

Keywords: emergency surgery gradation complication mortality
efficacy of nebulized hypertonic saline in the treatment of acute bronchiolitis

Conditions: Bronchiolitis

Summary: the purpose of this study is to evaluate the efficacy of hypertonic saline vs. normal saline in the treatment of infants hospitalized for bronchiolitis, regarding length of hospital stay, oxygen requirements and clinical outcome.

despite bronchiolitis is a very frequent disease among infants, there are still controversies regarding its treatment. hypertonic saline has been proposed as useful treatment in these children, bur information is still controversial. the aim is to asses that using nebulized hypertonic saline with bronchodilators (albuterol) may reduce the days of hospitalization and improve clinical outcomes in patients with acute bronchiolitis, compared with using normal saline with albuterol.

Eligibility criteria:
inclusion criteria: * infants aged 1 to 24 months, hospitalized for first episode of bronchiolitis, with severity score ≥ 5 points and oxygen saturation ≥ 97%. exclusion criteria: * chronic respiratory or cardiovascular disease, respiratory failure.

Keywords: hypertonic saline bronchiolitis efficacy
comparison of artificial intelligent clinic and normal clinic

Conditions: Cataract

Summary: in this study, the investigators provide participants≤14 years old the artificial intelligent clinic or normal clinic in the purpose of seeking out a better way to make a definite diagnosis with high efficiency and accuracy, and report a prospective, randomized controlled study aiming at comparison of artificial intelligent clinic and normal clinic for diagnosing congenital cataract.

children ≤14 years old from ophthalmic clinic without treatment were enrolled to a prospective, randomized controlled study. patients were assigned to two groups: participants in group a went to the artificial intelligent clinic and get the initial diagnosis, while in group b, the participants went to the normal clinic. investigators provide the final definite diagnosis from experts for two groups. investigators compared the accuracy of the diagnosis, time consuming and the satisfaction level between two groups, aiming at comparison of artificial intelligent clinic and normal clinic for diagnosing congenital cataract.

Eligibility criteria:
inclusion criteria: * paediatric patients from collaborating eye clinics written informed consents provided exclusion criteria: * definitive diagnosis of cataract or other ocular abnormalities previous eye surgery can not cooperate with the slip lamp examination unwilling to participate in this trail

Keywords: congenital cataract artificial intelligent clinic
extended infant post-exposure prophylaxis with antiretrovirals to reduce postnatal hiv transmission

Conditions: HIV Infections

Summary: the purpose of this study is to determine if extended antiretroviral regimens given to the infant during the first 14 weeks of age would decrease breast milk transmission of hiv.

this is a three-arm randomized, open label, clinical trial to evaluate the effectiveness of two extended regimens of antiretrovirals compared to infant single dose nevirapine plus azt given twice daily for 1 week (comparison regimen). all infants receive the comparison regimen at birth and then randomized at birth to start either one of the two extended regimens after the first week. the extended regimens are nevirapine daily and nevirapine plus azt daily - both regimens are given up to age 14 weeks.

Eligibility criteria:
inclusion criteria: * had given birth within the last 24 hours * ability and willingness to give informed consent for hiv testing and enrollment into the study * willing to receive hiv results * hiv infected * planning to deliver or had given birth at the study clinics * willing to come back for follow-up visits for 2 years postnatally * resident of blantyre city or its suburbs exclusion criteria: * hiv negative * women with discordant hiv results * women who indicate that they will not breastfeed at time of delivery * inability or unwillingness to follow any of the inclusion requirements * newborn with life-threatening condition * women who previously enrolled in this study and have a second pregnancy cannot reenroll

Keywords: hiv mtct infants africa hiv seronegativity
volumetric mri brain in patients with migraine

Conditions: Migraine

Summary: assessment of the role of volumetric mri in evaluation of different types of migraine .

migraine is a common condition that many people experience during their lives. evolving data reported that migraine patients have increased risk of developing silent brain lesions, such as white matter lesions and volumetric changes in both grey and white matter found on mri . these changes have been first investigated with ct scans which reported cerebral edema, atrophy and ischemia . with the advent of mri and high-resolution devices, the most commonly reported structural changes were white matter lesions . volumetric brain mri is the tool segments and measures volumes of the key brain structures-hippocampus, ventricles and other structures-and compares the volumes to standard normal values based on age, gender and cranial volume. this information helps assess neurological conditions and neurodegenerative diseases . * in migraine patients ,volumetric mri techniques allow better assessment of wmls and may provide a different comprehension of structural aspects related to the migraine pathophysiology. the identification of migraineurs' brain structural alterations through non-invasive neuroimaging methods and the use of accessible and easy to-use software brings new perspectives on the assessment of the impact of this condition in central nervous system macro-architecture . * in previous studies, structural brain changes in migraineurs were assessed by an automated segmentation using (free surfer) method . in our study, we aim to investigate these total and segmental structural changes of brain volume in migraine patients; as well as white matter lesions, in comparison to healthy controls, and in patients with episodic migraine in comparison to chronic type of migraine using another automated tissue segmentation (vol brain) method.

Eligibility criteria:
inclusion criteria: * patients with different types of migraine : * episodic migraine without aura (moa) * episodic migraine with aura (ma) * chronic migraine (cm). exclusion criteria: * . history of acute myocardial infarction, ischemic or hemorrhagic stroke. . history of neurosurgery or brain trauma * patients with contra-indications to mri.