Kornimate/medical-research-clean huggingface dataset:
autophagy and inflammasome in obesity: effect of weight loss and potential therapeutic implications

Conditions: Obesity

Summary: the main aim of this project is to determine the implication of autophagy and inflammasome in the pathogenesis of obesity and related comorbidities, and to explore in depth the mechanisms associated with the activation of immune cells leading early stages of the atherosclerotic process and metabolic disease. the hypothesis of the present study is that weight loss mediated by roux-en-y gastric bypass (rygb) improves the protein expression of markers of autophagy and inflammation within immune cells. moreover, the investigators will explore the association of these mechanisms with the mitochondrial function and dynamics, endoplasmic reticulum (er) stress an intracellular nutritional status of leukocytes (measured by fluorescence microscopy and western blot). further, the potential relationship between changes in the mentioned intracellular pathways and systemic pathological mechanisms including oxidative stress, inflammation and glucose and lipid metabolism will be explored. hence, serum carbonylated proteins, myeloperoxidase (mpo) levels, antioxidant enzymatic activities including sod (superoxide dismutase) and catalase, circulating cytokines, and glucose and lipid metabolism parameters will be evaluated in a cohort of obese subjects before and 12 months after rygb intervention.


Eligibility criteria:
inclusion criteria: * body mass index (bmi) ≥ 30 kg/m\^2 * duration of obesity over 5 years exclusion criteria: * history of drug abuse * pregnancy or lactation * neoplastic disease * severe renal/hepatic disease * history of cardiovascular disease * chronic inflammatory disease * secondary cause for obesity (hypothyroidism, cushing's syndrome)

Keywords: bariatric surgery autophagy inflammasome atherosclerosis cardiovascular disease
glycomacropeptide and women's health

Conditions: Obesity

Summary: this is a study about how a dietary supplement containing a whey protein affects hormones controlling hunger and satiety (leptin and ghrelin) in postmenopausal women with a body mass index between 28 and 35 kg/m2. participants can expect to be in study for 4 weeks.

the purpose of this research study is to understand how a dietary supplement containing glycomacropeptide (gmp) affects blood sugar levels and hormones that regulate hunger and satiety. this study is being conducted to find new ways to help women lose weight and reduce their chance of getting diabetes.

Eligibility criteria:
inclusion criteria: * no more than 10 years past menopause as defined by the date of last menses, less than 90 years old, bmi of 28 to 35 kg/m2. exclusion criteria: * bmi\>35 kg/m2, diabetes, and/or an active medical problem or condition that would interfere with study outcomes (malignancy, inflammatory condition, gastric bypass surgery or participation in another study)

Keywords: obesity glucose tolerance satiety hunger microbiome amino acids c-reactive protein
study of coagulation factor viia marzeptacog alfa (activated) in subjects with inherited bleeding disorders

Conditions: Factor VII Deficiency; Glanzmann Thrombasthenia; Hemophilia A With Inhibitor

Summary: the purpose of the trial is to evaluate the pk, bioavailability, pd, efficacy and safety of marzaa for on demand treatment and control of bleeding episodes in adult subjects with inherited bleeding disorders.


Eligibility criteria:
inclusion criteria: * diagnosis of cohort: fvii deficiency, glanzmann thrombasthenia, or hemophilia a with inhibitors * male or female, age 12 or older * history of frequent bleeding episodes * affirmation of informed consent with signature confirmation and assent for children between ages 12 to 17 before any study related activities * agreement to use highly effective birth control throughout the study if the subject has childbearing potential exclusion criteria: * genotype of fviid subjects with identified mutations by central lab at screening * previous participation in a clinical trial evaluating a modified rfviia agent * received an investigational drug within 30 days or 5 half-lives or absence of clinical effect, whichever is longer * known hypersensitivity to trial or related product * known positive antibody to fvii or fviia detected by central lab at screening * be immunosuppressed * significant contraindication to participate
efficacy of travoprost/timolol for uncontrolled intraocular pressure

Conditions: Open Angle Glaucoma; Ocular Hypertension

Summary: the purpose of this study is to demonstrate superior intraocular pressure (iop) control with travoprost 0.004% / timolol 0.5% compared to beta-blocker monotherapy in participants with open-angle glaucoma or ocular hypertension.


Eligibility criteria:
inclusion criteria: * have a clinical diagnosis of either open angle glaucoma or ocular hypertension. * currently on beta-blocker monotherapy (for \>30 days) and would benefit, in the opinion of the investigator, from further intraocular pressure (lop) reduction. * have a mean baseline lop of \>18 mmhg and \<32 mmhg in at least one eye. * must be able to understand and sign an informed consent form. * other protocol-specified inclusion criteria may apply. exclusion criteria: * use of medication excluded by the protocol. * diseases, illnesses, infections, or ocular abnormalities excluded by the protocol. * ocular surgeries or procedures excluded by the protocol. * best-corrected visual acuity (bcva) score worse than 55 etdrs letters (equivalent to 20/80 snellen, 0.60 logmar or 0.25 decimal). * hypersensitivity to prostaglandin analogues or any component of the study medications in the opinion of the investigator. * women of childbearing potential if pregnant, test positive for pregnancy at screening visit, breastfeeding, or not in agreement to use adequate birth control methods to prevent pregnancy throughout the study. * other protocol-specified exclusion criteria may apply.

Keywords: open angle glaucoma ocular hypertension intraocular pressure
a phase ⅲ comparative study of ql2108 to dupixent®

Conditions: Atopic Dermatitis

Summary: it is a multicenter randomized, double-blinded, parallel, positive-controlled, phase ⅲ comparative study to evaluate the efficacy and safety of ql2108 to dupixent® in adult subjects with moderate-to-severe atopic dermatitis. a total of 520 subjects are planned to be included and randomized at a ratio of 1:1 to receive ql2108 injection or dupixent®


Eligibility criteria:
inclusion criteria: * subjects aged from 18 to 75 years (including the boundary value) * at the time of screening, the diagnosis of atopic dermatitis (ad) meets the hanifin-rajka criteria, with a disease history of ≥1 year prior to screening. * during the screening period and prior to randomization: easi score ≥16, iga score ≥3, bsa ≥10%. exclusion criteria: * people who have previously used or participated in clinical trials of monoclonal antibody with the same target or dupilumab * having participated in drug or device clinical trials within 12 weeks or 5 half-lives of other investigational drugs before the study administration. * subjects who have received live vaccines or live-attenuated vaccines within 12 weeks prior to randomization or plan to receive such vaccines during the trial period.

Keywords: atopic dermatitis
the effect of different virtual reality trainings on gait, balance and posture of individuals with dementia

Conditions: Dementia

Summary: dementia, a part of geriatric syndrome, is characterized by the deterioration of multiple cognitive domains such as memory, language, orientation, learning and personality as a result of damage to the central nervous system and in terms prognosis persistent and often progressive clinical condition. in the epidemiological studies it is stated that the number of the dementia affected people approximately 2 times in every 20 years. in several studies, it has been mentioned that cognitive disorders affect individuals' motor function such as gait and postural responses. these effects lead to a vicious circle by causing immobilization of individuals due to a decrease in cognitive functions in addition to immobilization due to aging. the lack of pharmacological therapies to change the prognosis of dementia, emphasizes physical activity methods due to its neurological contributions. however, due to the fact that conventional exercise programs are seen as boring in terms of elderly individuals and the exercise attendance rates are low, the virtual reality (vr) training have been preferred recently. to the best of the investigator's knowledge, there is no study examining the effect of different virtual reality trainings on the spatio-temporal characteristics of the gait, posture and balance. therefore, the aim of this study is to evaluate the effect of different virtual reality trainings on these parameters.


Eligibility criteria:
inclusion criteria: * diagnosed with dementia * mini-mental state examination (mmse) score between 18-23 points * able to walk independently with/without a walking aid (a single point cane) * able to speak and understand turkish * understand simple commands * at least primary education exclusion criteria: * severly vision and hearing problems * undergo acute retinal hemorrhage or ophthalmic surgery * acute or chronic neurological problems * musculoskeletal and/or neurological problems affecting movement and balance * vestibular problem and/or use medicine * uncontrolled cardiovascular disease, congestive heart failure, acute myocarditis, pulmonary hypertension, or using a pacemaker * malignancy * orthopedic or neurological surgery in the past 6 months

Keywords: dementia virtual reality exergame gait
evaluate st jude medical prodigy neuromodulation for fbss or chronic pain of the trunk and/or limbs

Conditions: Chronic Pain

Summary: the purpose of this study is to confirm long term efficacy and safety of the prodigytm neuromodulation system in the management of failed back surgery syndrome or chronic intractable pain of the trunk and/or limbs.


Eligibility criteria:
inclusion criteria: * patient with chronic, intractable pain of the trunk and/or limbs, including unilateral or bilateral pain associated with the following: failed back surgery syndrome or intractable low back and/or leg pain * patient diagnosed with radiculopathy * patient diagnosed with neuropathic pain * patient is considered by the investigator as a candidate for implantation of a scs system * patient is ≥ 18 years of age * patient must be willing and able to comply with study requirements * patient must indicate his/her understanding of the study and willingness to participate by signing an appropriate informed consent form exclusion criteria: * patient is diagnosed with ischemic pain * patient is diagnosed with arachnoiditis * patient is diagnosed with complex regional pain syndrome (crps i and ii) * patient is diagnosed with peripheral vascular disease (pvd) * patient is diagnosed with diabetic neuropathic pain * patient is diagnosed with chronic migraine * patient is immune-compromised * patient has history of cancer requiring active treatment in the last 6 months * patient has a documented history of substance abuse (narcotics, alcohol, etc.) or substance dependency in the last 6 months * patients with a scs system or implantable infusion pump implanted previously * patient has a life expectancy of less than one year * patient is pregnant or is planning to become pregnant during the duration of the investigation * patient is unable to comply with the follow up schedule * patient needing legally authorized representative * patient unable to read and write * patient is currently participating in another clinical investigation with an active treatment arm.

Keywords: scs burst stimulation
evaluation of retinal structure with high resolution optical coherence tomography (oct)

Conditions: Macular Edema; CNV

Summary: comparison of different oct instruments to assess retinal thickness, correlation to fluorescein angiography, and visual outcome after therapy with anti-vegf therapy

comparison of different oct instruments to assess retinal thickness, correlation to fluorescein angiography, and visual outcome after therapy with anti-vegf therapy

Eligibility criteria:
inclusion criteria: * macular disease * healthy subjects

Keywords: oct
comparison between effect of acetazolamide and nahco3 in prevention of contrast nephropathy

Conditions: Contrast Induced Nephropathy

Summary: the purpose of this study is whether acetazolamide is effective in prevention of contrast nephropathy

contrast induced nephropathy is one of common causes of acute renal failure many preventive protocol existed . 240 patient that underwent coronary angiography randomly divided in three groups.group 1,2,3 will receive bicarbonate ,acetazolamide+normal salin and normal salin respectively.we compare prevalence of contrast nephropathy in each group.

Eligibility criteria:
inclusion criteria: * patient that underwent coronary angiography exclusion criteria: * serum cr. more than 3 mg/dl * electrolyte and acid-base imbalance * pulmonary edema * allergy to acetazolamide
investigation of genetic risk of cardiovascular disease in prospective cohort study

Conditions: Healthy; Coronary Disease; Myocardial Infarction; Cerebral Infarction

Summary: cardiovascular disease is a complex multifactorial and polygenic disorder that is thought to result from an interaction between a person's genetic make up and various environmental factors. although many studies have revealed that several genetic variants increase the risk of cardiovascular disease, the results of these studies remain controversial. the purpose of this study is to identify polymorphisms that confer susceptibility to cardiovascular disease and to clarify the adequacy of reported susceptibility gene polymorphisms. to complete this purpose, we will prospectively study over 5,000 local residents in whom relationship between these polymorphisms and occurrence of cardiovascular disease over 5 years.


Eligibility criteria:
inclusion criteria: * healthy subjects who undergo community-based annual health check in kitanagoya city
combined phacoemulsification with istent inject w versus hydrus for mild to moderate open angle glaucoma

Conditions: Open Angle Glaucoma

Summary: the goal of the study is to prospectively evaluate and compare hydrus microstent to the istent inject wide in combination with cataract surgery in patients with mild to moderate open angle glaucoma. hydrus and istent are the two fda approved trabecular meshwork targeting microstents to treat open angle glaucoma in conjunction with cataract surgery.


Eligibility criteria:
inclusion criteria: * \>60 years or older * visually significant cataract * mild to moderate primary open angle glaucoma controlled on medications * undergoing cataract surgery with lens implantation and concurrent microstent placement * iop ≥ 21 mmhg and ≤ 36 mmhg after washout of ocular hypotensive medication(s) * cct 480 to 620μm * no prior ocular surgery including corneal refractive surgery * no slt within 6 months of baseline visit, no history of intracameral glaucoma drug eluting implants * visual field mean deviation ≤ -12 db * optic nerve abnormalities consistent with glaucoma, c/d ratio less than ≤0.8 exclusion criteria: * prior intraocular surgery * visual field md ≥ -12 db * secondary glaucoma including uveitis, traumatic, malignant, neovascular, and congenital glaucoma. * glaucoma related to elevated episcleral venous pressure including sturge-weber syndrome, thyroid eye disease, orbital tumor, and etc. * uncontrolled intraocular pressure on maximum tolerated medical therapy; * unable to perform wash-out iop * anatomic exclusion of narrow anterior chamber angle (shaffer grade i-ii), other angle abnormalities including angle closure glaucoma * corneal disease or dystrophy * pathological myopia with degeneration that affects diagnostic imaging * clinically significant ocular pathology or degenerative diseases that affect vision, visual field, or optical coherence tomography of optic nerve. * inability to perform reliable visual field and optical coherence tomography.

Keywords: primary open angle glaucoma hydrus istent minimally invasive glaucoma surgery migs randomized
real world assessment of effects of beta-blockers on patients with acute coronary syndrome

Conditions: Acute Coronary Syndrome

Summary: the study is aimed to optimized the dose-adjusted regimen of beta-blockers in patients with acute coronary syndrome by investigating therapeutic and curative results of target doses beta-blockers using the dose-adjusted pathway of beta-blockers.


Eligibility criteria:
inclusion criteria: * age ≥ 18 years * patients diagnosed as acute coronary syndromes including acute st-segment elevation myocardial infarction (stemi) and non-st-segment elevated acute coronary syndrome (nste-acs) * patients or whose legal representatives signed written informed consent form exclusion criteria: patients should been excluded if they meet any of the following exclusion criteria: * patients with contraindications to the application of beta blockers, including: 1) cardiogenic shock or heart failure (killip grade \> ii level);2) sick sinus syndrome; 3) ii degree atrioventricular block;4) unstable decompensation of cardiac failure (pulmonary edema, hypotension or low perfusion); 5) symptomatic hypotension or bradycardia (heart rate\<50 beats/min, blood pressure\<90/60mmhg); 6) contraindications to beta blockers or allergy to any ingredient of beta blocker; 7) active asthma should be treated by inhalation preparation treatment * pregnant or lactating women * patients without signed written informed consent * patients who was considered by the researcher inappropriate to participate in this study (for example, patients with a higher risk of cardiogenic shock, etc.)
the effect of nitroprusside on intrauterine device (iud) insertion

Conditions: Cervical Pain; Pelvic Pain

Summary: increasing accessibility of long-acting reversible contraceptive methods, like intrauterine devices (iuds), is an important strategy to reduce the risk of unintended pregnancy. unfortunately, fear of iud insertion in women who have not had children is common among health care providers and women alike, and this limits iud use. to increase acceptance of this highly effective contraceptive, there is need to investigate novel, low cost, easily applied and accessible techniques to improve the insertion experience. this is a pilot study to evaluate the efficacy and tolerability of nitroprusside gel applied intracervically as an intervention to improve the iud insertion experience for both patient and provider.

subjects who are have already scheduled an iud insertion will be asked to join this study assessing whether or not nitroprusside gel helps with iud insertion process. only healthy, nulliparous women between the ages of 18 and 45 will be recruited. nulliparous women report much more pain associated with iud insertion than parous women so the possibility of being able to measure the effect of nitroprusside vs placebo is more likely. the primary outcome, pain with iud insertion, and the secondary outcomes, such as satisfaction and provider ease of iud insertion, will be compared between the study groups as well.

Eligibility criteria:
inclusion criteria: * age 18-45, * generally healthy. * requesting lng-ius for contraception as the primary indication exclusion criteria: * previous pregnancy beyond 20 weeks, * previous iud placement or attempted placement, * allergy to nitroprusside, * history of migraines, * history of heart disease.

Keywords: iud, insertion, decrease, pain
use of teach back to improve comprehension of discharge instructions for emergency patients with limited health literacy

Conditions: Conditions Influencing Health Status

Summary: the purpose of this study was to determine whether use of teach-back discharge instructions improve patient satisfaction and patients' self-reported and objective comprehension of discharge instructions in the emergency department when compared to standard discharge instructions.


Eligibility criteria:
inclusion criteria: * patients being discharged from the emergency department * a score of 6 or less on the rapid estimate of adult literacy in medicine, revised (consistent with limited health literacy) exclusion criteria: * aphasia, * non-english speaking, * mental handicap, * psychiatric chief complaint, * too high acuity per physician, * insurmountable communication barrier, * evaluations for sexual assault, * clinical intoxication.

Keywords: health literacy teach-back emergency
functional and self-reported outcomes in participants with a history of musculoskeletal knee injury

Conditions: Anterior Cruciate Ligament Injury; Anterior Cruciate Ligament Rupture

Summary: negative outcomes impact individuals with a history of acl reconstruction (aclr) despite completion of formal rehabilitation and clearance to return to physical activity (pa). focused exercises and targeted health education may improve these negative outcomes and increase quality of life. the purpose of this study is determine the effects of an 8-week rehabilitation program on strength, sensorimotor function, functional performance and patient-reported outcomes in patients with a history of aclr. a secondary aim will be to identify baseline pa levels and dietary intake patterns in these individuals. participants will complete standard knee radiographs and all baseline measures, and resume normal activities of daily living for one-week while wearing an accelerometer to quantify pa levels and complete two, 24-hour dietary recalls to examine dietary patterns. after one-week, participants will come back to the laboratory and complete the pre-intervention assessments prior to randomization to the exercise or control group. after 8-weeks, participants will complete all outcome assessments 24-48 hours, 1-month and 3-months post exercise completion. the investigators hypothesize the intervention group will have significantly better outcomes post-intervention compared to the control group. in addition, the investigators hypothesize areas of educational and behavioral intervention related to pa engagement and dietary strategies to support weight management will be needed.


Eligibility criteria:
inclusion criteria: * history of unilateral acl reconstruction, * history of injuring their knee playing or training for sports (recreational or organized), * have been cleared to participate in activity, do not have radiographic evidence of post-traumatic osteoarthritis, * are free of neurological disorders, cardiopulmonary disease or any other condition that may impact their ability to participate exclusion criteria: * acl reconstruction \>10 years, * injury to either lower extremity within the last 6-weeks, * surgery to either limb within the last year, * a bmi \> 30

Keywords: rehabilitation