Kornimate/medical-research-clean huggingface dataset:
functional resistance training to improve knee function after acl reconstruction

Conditions: Anterior Cruciate Ligament Injury

Summary: the purpose of this study is to examine if thigh muscle weakness and the lack of muscle activation that accompanies acl injury and reconstruction can be improved with functional resistance training.

profound quadriceps weakness is ubiquitous after anterior cruciate ligament (acl) reconstruction, and current rehabilitation approaches are not successful in optimizing quadriceps strength and knee function even years after the surgery. we hypothesize that suboptimal strength and functional outcomes after acl surgery are due to the lack of task-specific exercise elements during strength training. this application seeks to assess whether progressive functional resistance training during gait will significantly improve quadriceps function, neural excitability, and knee mechanics during gait. the proposed studies will not only lay the foundation for a novel training paradigm, but will also improve our understanding of the mechanisms mediating neuromuscular and biomechanical changes after functional resistance training.

Eligibility criteria:
inclusion criteria: * aged 14-40 years * suffered an acute, complete acl rupture * willingness to participate in testing and follow-up as outlined in the protocol * english-speaking exclusion criteria: * inability to provide written informed consent * female subjects who are pregnant or are planning to become pregnant * previous acl injury * previous surgery to either knee * bony fracture accompanying acl injury * patients who experienced a knee dislocation; * patients who are contraindicated for transcranial magnetic stimulation (e.g., metal implants in head, unexplained recurrent headaches, history of seizures, epileptogenic drugs, active psychiatric illness, etc.).

Keywords: acl quadriceps muscle resistance training
scalp infiltration with methylprednisolone plus ropivacaine for post-craniotomy pain in children

Conditions: Pain, Postoperative; Post-Craniotomy Headache

Summary: at present, pediatric postoperative analgesia has not been fully understood and controlled, particularly craniotomy surgery. on the one hand, professional evaluation of postoperative pain for young children is difficult; on the other hand, the particularity of craniotomy adds (such as consciousness obstacle, sleepiness, et al) disturbance to the pain assessment in children. although opioids administration is regarded as the first-line analgesic for post-craniotomy pain management, it may be associated with delayed awakening, respiratory depression, hypercarbia and it may interfere with the neurologic examination. for the avoidance of side-effects of systemic opioids, local anesthetics administered around the incision have been performed clinically. however, some studies revealed that the analgesic effect of local anesthetics was unsatisfactory due to its short pain relief duration, steroid as adjuvant can enhance postoperative analgesia and prolong postoperative analgesia time. as is reported that postoperative pain of craniotomy is mainly caused by skin incision and reflection of muscles, preventing the liberation of inflammatory mediators around the incision seems to be more effective than simply blocking nerve conduction. thus, investigators suppose that pre-emptive scalp infiltration with steroid (methylprednisolone) plus local anesthetic (ropivacaine) could relieve postoperative pain after craniotomy in children.


Eligibility criteria:
inclusion criteria: 1. an elective craniotomy under general anesthesia; 2. american society of anesthesiologists (asa) physical status of i or ii; 3. participates with an anticipated fully recovery within 2 hours postoperatively； 4. informed consent by parent(s) and/or legal guardian. exclusion criteria: 1. history of allergies to any of the study drugs; 2. excessive alcohol or drug abuse, chronic opioids use (more than 2 weeks or 3 days per week for more than 1 month), or drugs with confirmed or suspected sedative or analgesic effects; receiving any painkiller within 24 h before surgery; children who received steroids； 3. psychiatric disorders; 4. uncontrolled epilepsy; 5. chronic headache; 6. peri-incisional infection; 7. body mass index exceeded the 99th percentile for age; 8. children who cannot use patient-controlled intravenous analgesia(pcia) device; 9. children who cannot understand an instruction of pain scales before surgery.

Keywords: postoperative pain post-craniotomy headache methylprednisolone ropivacaine pre-emptive scalp infiltration child
high-sensitivity c-reactive protein and united kingdom prospective diabetes study (ukpds) risk score in type 2 diabetes

Conditions: Atherosclerosis; Type 2 Diabetes

Summary: the ukpds risk score is recommended to assess global risk for future coronary heart disease (chd) events in primary prevention. recently, high-sensitivity c-reactive protein (hscrp) has emerged as a strong independent risk factor for chd. 18f-fluorodeoxyglucose (fdg) positron emission tomography (pet) is a promising imaging technique for the evaluation of vascular inflammation that reflects vulnerable atherosclerotic plaque.


Eligibility criteria:
inclusion criteria: * type 2 diabetes exclusion criteria: * myocardial infarction, unstable angina, stroke, peripheral artery disease, or cardiovascular revascularization * resting blood pressure ≥160/100 mmhg * malignancy, or severe renal or hepatic disease * participants were free of any lipid-lowering therapies and postmenopausal hormone replacement therapy at least the 6 month period prior to enrollment * history of inflammatory condition or those taking medications that might affect inflammatory status within 6 months
association between effectiveness of mirikizumab and uc patients with high neutrophilic infiltration in epithelium of the colonic mucosa

Conditions: Ulcerative Colitis

Summary: the goal of this study is to confirm that mirikizumab therapy may provide clinical, endoscopic, and histopathologic improvements in patients with moderate to severe uc refractory to maintenance therapy when high neutrophilic infiltration in epithelium of the colonic mucosa (geboes score grade ≥3.2) on endoscopic biopsy is found.


Eligibility criteria:
inclusion criteria: * they were endoscopically active ulcerative colitis patients. exclusion criteria: * the presence of a long-term illness, colorectal cancer, or infectious colitis

Keywords: ulcerative colitis
exercise training in coronary artery disease patients after stenting

Conditions: Stent Restenosis; Coronary Artery Disease

Summary: to determine the effect of exercise training on cardiac outcomes in coronary artery disease patients after stenting. there is a need to develop strategies, not only to prevent restenosis but also to improve patients' functional status and perception of well-being. in particular, it is not well defined whether exercise training can reduce the restenosis rate and improve the outcome after pci.

based on an analysis of literature reviews, psychological symptoms (such as depression and anxiety), angina, vital exhaustion, and dyspnea have been observed to have the most significant influence on the quality of life in people with cad. almost half of the patients, after an initial encouraging improvement in functional capacity and quality of life (qol) after the pci, deal with recurrent chest pain that requires medical attention, reduces functional capacity, and creates a status of psychological distress.

Eligibility criteria:
inclusion criteria: * gcs = 15 * disease chronicity: 1-3 years * elective / stenting procedure * single or double vessel stunting * ef: 35 above exclusion criteria: * unwilling to participate in research * known cases of uncontrolled dm or htn * known cases of cognitive/memory/neurological disorders * known cases of any systemic disease

Keywords: coronary artery diseases exercise training stenting
an observational study to investigate how patients experience the ability to adjust their asthma maintenance medication

Conditions: Asthma

Summary: an observational study to investigate how patients experience the ability to adjust their asthma maintenance medication according to instructions received from their physician. the primary aim is to create an insight in the perception of the patient when he has the ability to adjust his own maintenance treatment and how the patient exercises this in the daily practice.


Eligibility criteria:
inclusion criteria: * inclusion criteria: patients with prescription of budesonide/formoterol turbuhaler 200/6 (adjustable maintenance dosing) and whom received instructions from their physician to adjust their asthma maintenance medication.

Keywords: asthma control
short title: standard vs. lower pressure pneumoperitoneum

Conditions: Laparoscopic Surgery

Summary: this study aims to investigate the effect of varying insufflation pressures on post-operative pain and adequacy of surgical field visualization among patients undergoing laparoscopic surgery with a minimally invasive gynecologic surgeon.

this will be a single-center, single-blinded randomized controlled trial evaluating the impact of lower pressure pneumoperitoneum on post-operative pain and surgical field visualization among patients undergoing laparoscopic gynecologic surgery. the investigators hypothesize that lower insufflation pressures will decrease post-operative pain in the immediate post-operative period without compromising surgical field visualization. the study will include 3 groups corresponding to varying insufflation pressures: 15mmhg (standard), 12mmhg and 10mmhg. participants will be 1:1:1 allocated to the 15mmhg, 12mmhg or 10mmhg groups (parallel design) by block randomization. given inherent differences in how pneumoperitoneum is maintained during conventional versus robotic-assisted laparoscopic surgery, the investigators will be enrolling patients in two separate arms depending on their planned procedure: 1. standard vs. lower pressure pneumoperitoneum in conventional laparoscopic gynecologic surgery 2. standard vs. lower pressure pneumoperitoneum in robotic-assisted laparoscopic gynecologic surgery. the methodology for the two arms will be otherwise identical.

Eligibility criteria:
inclusion criteria: * provision of signed and dated informed consent form * stated willingness to comply with all study procedures and availability for the duration of the study * 18 years of age or older * undergoing laparoscopic surgery at cedars-sinai medical center with a surgeon in the minimally invasive gynecologic surgery division. exclusion criteria: * pregnancy * urgent/non-scheduled surgery * scheduled for planned or possible concomitant non-gynecologic surgery (e.g., urologic or colorectal procedure) * baseline opioid use * allergy or intolerance to bupivacaine (or amide class of anesthetics), oxycodone, acetaminophen, or ibuprofen * planned post-operative admission

Keywords: laparoscopic surgery insufflation pneumoperitoneum gynecologic surgery postoperative pain robotic surgery
blood sample collection in geriatric patients

Conditions: Venipuncture Site Bruise

Summary: this study aimed to evaluate the effect of different durations of a specific pressure applied after blood collection on the development of ecchymosis in geriatric patients using oral and subcutaneous anticoagulants.

the research sample consisted of patients hospitalized in the geriatrics clinic of a city hospital. this study aimed to evaluate the effect of different durations of a specific pressure applied after blood collection on the development of ecchymosis in geriatric patients using oral and subcutaneous anticoagulants. in this study, whether ecchymosis developed at the 24th, 48th and 72nd hours after the blood collection procedure was evaluated.

Eligibility criteria:
inclusion criteria: * patients aged 65 years and over * who voluntarily agreed to participate in the study * who used oral (rivaroxaban 10-15-20 mg, dabigatran, 75-110-150 mg, apixaban 2.5-5 mg) and subcutaneous (enoxaparin sodium 6000-4000 anti-xa iu/0.6-0.4 ml) anticoagulants * who were literate in turkish * who were scheduled for blood collection * who would undergo blood collection from the antecubital site with vacutainer exclusion criteria: * patients with communication problems * patients with hematoma, ecchymosis, and scarring in the antecubital site * patients who would be discharged before 72 hours * patients with coagulation disorders
a pilot study of buspirone for the treatment of anxiety in youth with autism spectrum disorders

Conditions: Autism Spectrum Disorder; Anxiety

Summary: the main objective of this exploratory 8-week pilot study is to evaluate the safety and efficacy of buspirone for the treatment of anxiety in youth (ages 6-17 years) with autism spectrum disorders. the study results will be used to generate hypotheses for a larger randomized-controlled trial with explicit hypotheses and sufficient statistical power.


Eligibility criteria:
inclusion criteria: * male or female participants between 6 and 17 years of age * dsm-5 asd diagnostic criteria as established by clinical diagnostic interview * participants with a score of ≥60 or more on the anxiety/depression subscale of cbcl * subjects can be taking psychotropic medications if they have been on the medication for at least 4 weeks prior to initiating study treatment and if they are on a stable dose, provided the medication is not listed in the concomitant medications section of the protocol. exclusion criteria: * history of active seizure disorder (eeg suggestive of seizure activity and/or history of seizure in last 1 month) * subjects with a medical condition or treatment that will either jeopardize subject safety or affect the scientific merit of the study, including: * pregnant or nursing females * organic brain disorders * uncorrected hypothyroidism or hyperthyroidism * clinically significant abnormalities on ecg (e.g., qt prolongation, arrhythmia) * history of renal or hepatic impairment. * clinically unstable psychiatric conditions or judged to be at serious suicidal risk * current diagnosis of schizophrenia or bipolar disorder * history of substance use (except nicotine or caffeine) within past 3 months or urine drug screen positive for substances of abuse * current treatment with medication with primary central nervous system activity (as specified in the concomitant medication section of the protocol) * a non-responder or history of intolerance to buspirone, after treatment at an adequate dose and duration as determined by the clinician * subjects currently taking monoamine oxidase inhibitors (maoi) and/or cyp3a4 inducers or inhibitors including nefazodone, diltiazem, verapamil, erythromaycin, itraconazole, or rifampin.

Keywords: autism spectrum disorders anxiety pervasive developmental disorders buspar buspirone
dual torc1/torc2 inhibitor atg-008 (cc-223) in hbv positive advanced hepatocellular carcinoma (hcc) subjects

Conditions: Hepatocellular Carcinoma

Summary: this is an asian multi-regional clinical trial (mrct) in which atg-008 will be administered orally to hepatitis b positive (hbv+) hcc subjects who have received at least one prior line of systemic therapy. it is designed as an open-label phase 2 trial evaluating the pharmacokinetics (pk), safety, tolerability and efficacy of oral atg-008 administered daily until the radiologic disease progression (according to recist 1.1) or intolerable toxicity.


Eligibility criteria:
inclusion criteria: 1. male or female aged from 18 to 70 years (inclusive) at the time when the icf is signed. 2. confirmed diagnosis of hcc. 3. unresectable stage b or c hcc according to the barcelona clinic liver cancer (bclc) staging. 4. hbv positive by serum test. 5. received at least one prior line of systemic therapy. 6. ecog performance status score of 0 or 1. 7. satisfactory serum chemistry results 8. adequate bone marrow function 9. child-pugh a without encephalopathy. 10. all subjects who participated in the study had to take reliable contraceptive measures within the trial and 3 months of after the trial. exclusion criteria: 1. symptomatic central nervous system metastases. 2. locoregional hcc therapy, systemic chemotherapy, hormonal therapy or investigational therapy within 4 weeks prior to screening. 3. life expectancy of less than 3 months. 4. prior therapy with mtor inhibitors. 5. prior organ transplant. 6. persistent diarrhea or malabsorption. 7. clinically significant bleeding. 8. known history of human immunodeficiency virus (hiv) infection. 9. uncontrolled intercurrent illness. 10. any condition that confounds the ability to interpret data from the trial.

Keywords: hcc
syphilis response to higher penicillin dosage: the 2.4 versus 7.2 study

Conditions: Syphilis

Summary: syphilis remains a significant health problem worldwide, with an estimated 10.6 million new cases per year. due to shared transmission route and risk factors, co-infection with syphilis and human immunodeficiency virus (hiv) is not uncommon. several studies have evaluated the response to syphilis treatment in hiv-infected patients. they support the claim that patients with hiv have a slower decrease in syphilis antibody titers, and that they may progress to neurosyphilis in earlier stages. the center for disease control and prevention's sexually transmitted disease treatment guidelines has advocated treating hiv-infected patients who have primary, secondary syphilis or early latent syphilis with the same doses of penicillin as for hiv-uninfected patients (single dose of 2.4 million units of benzathine penicillin g). the investigators designed a randomized controlled trial in order to compare the efficacy of three- versus single-dosed regimens of intramuscular benzathine penicillin g (bpg) for the treatment of early syphilis in hiv-infected patients.

the investigators conducted a prospective, randomized, open label study at three clinical sites including thomas street health center and north west clinic (harris health system), and the michael e. debakey veterans affairs medical center in houston, texas. after obtaining written informed consent, the investigators randomly assigned patients to either a single intramuscular injection of 2.4 million units of bpg (standard therapy) or three doses (enhanced therapy) of intramuscular bpg administered weekly (a total of 7.2 million units). patients were eligible for inclusion in the study if they were 18 years of age or older and had a diagnosis of hiv. the diagnosis of syphilis was made based on a positive rapid plasma reagin (rpr) and treponema pallidum particle agglutination tests. patients with primary, secondary and early latent syphilis were included. exclusion criteria were history of penicillin allergy, diagnosis of late latent syphilis, neurosyphilis, and antibiotic use with significant activity against treponema pallidum within the preceding two weeks. follow-up period was 12 months. serum samples were obtained at initial visit and follow-up visits every 3 months for serological testing for syphilis. treatment success was defined as a decrease in rpr titer of \>= 2 dilutions (4-fold) from the initial rpr titer during the follow-up period. both intention-to-treat and per-protocol analyses were performed

Eligibility criteria:
inclusion criteria: * diagnosed with hiv by elisa and confirmed by western blot * positive rapid plasma reagin and treponema pallidum particle agglutination tests exclusion criteria: * history of penicillin allergy * diagnosis of late latent syphilis * diagnosis of neurosyphilis * antibiotic use with significant activity against treponema pallidum within the preceding two weeks
aortic occlusion for resuscitation in trauma and acute care surgery

Conditions: Aortic Occlusion

Summary: aortic occlusion (ao) for trauma has traditionally been accomplished by supra-diaphragmatic clamping of the descending thoracic aorta via emergent thoracotomy or as an initial step during laparotomy.

an evolution in endovascular technologies, however, has provided additional means by which to achieve ao. expanding experience with the utilization of balloon occlusion in the setting of abdominal aortic rupture due to chronic vascular disease has demonstrated the potential of these new technologies. discussion of the employment of endovascular ao in the realm of trauma has led to the description of this approach and the demonstration of its effectiveness in animal models of severe hemorrhage. the purpose of the present study is to prospectively examine the modern utilization of ao in the acute resuscitation of trauma and acute care surgery patients in shock.

Eligibility criteria:
inclusion criteria: * all adult (age ≥ 18 years) trauma and acute care surgery patients treated with resuscitative ao (via open or endovascular means) in the acute phases after injury * transient or refractory hypotension (systolic blood pressure \<90mmhg) with a positive abdominal focused abdominal sonography in trauma (fast) scan, severe pelvic fracture(s), or neither with persistent hypotension without obvious source * chest x-ray without evidence of thoracic aortic injury * subject treatment includes internal aortic cross-clamp or would have likely benefited from an internal aortic cross-clamp exclusion criteria: * subject \< 18 years of age * prisoner * evidence of cardiac, thoracic aortic, or great vessel injury identified in primary survey, fast scan, and/or x-rays * any open/exsanguinating upper extremity wound
using a thermal imaging system to evaluate the wound of port-a and the relationship between thermal images and infection

Conditions: Wound Healing Disturbance of Port-A

Summary: permanently implantable venous ports (port-a) is very important to patients receiving chemotherapy. it not only provides a reliable route to administrate intravenous drugs, and it also requires minimal care when it is not in use. however, catheter related blood stream infection(crbsi) is one of the serious complications of port-a. the diagnosis of crbsi relies on limited tools, including blood culture or symptoms and signs of active infection. in the stage of crbsi, port-a removal is necessary and pose the risk for the patients to re-implant the port-a. thus, it is crucial to early detect the infection and give appropriate treatment. among the pathogens, some pathogens are related to skin contaminants. before systemic spreading, these pathogens may colonize or cause minor infection subcutaneously. this investigation is to utilize a non-invasive dual spectrum infrared imaging system to evaluate the port-a wound and to detect the infection. aim: 1. to build the database of infra-red thermal images of port-a wound healing. 2. to investigate the thermal images of skin contamination related crbsi and to compare with the thermal images of the crbsi of unknown foci


Eligibility criteria:
inclusion criteria: * clinical requirement of chemotherapy with port-a exclusion criteria: * not able to maintain posture during acquiring the thermal images * with other wounds over the nearby area of the port-a wound * with other severe underlying disease and too weak to mobilize

Keywords: infrared thermal image wound healing wound infection