Kornimate/medical-research-clean huggingface dataset:
physiotherapy program for managing adhesive capsulitis in patients with diabetes

Conditions: Adhesive Capsulitis; Diabetes Mellitus

Summary: this pilot randomized trial will compare the preliminary effect of a regular physiotherapy (pt) program to a regular pt combined with a progressive walking program (pt+) in patients with and without diabetes who have adhesive capsulitis. after signing the consent form, recruited participants will be randomized into either pt group (control) or pt+ group (experimental). participants in both groups will be referred to a physical therapy facility. the intervention will be chosen by treating physical therapist. in pt+ group, participants will also be asked to perform free walking at their own pace. outcomes measures for the primary outcome (shoulder functional performance) will be evaluated at baseline and after 6 weeks. secondary outcomes (shoulder rom, pain and function, muscle strength, and physical activity level) will be evaluated at baseline, at 3 and 6 weeks, and again at 12 weeks after enrolment. we expect adding a progressive walking program to regular pt will result in better outcomes.

in this pilot randomized clinical trial, participants will be recruited from an orthopedic clinic at st. joseph's health care centre via surgeon referrals and from local primary health care clinics via posters advertising the study. potential participants will be contacted by the research team at hand and upper limb centre (hulc) to arrange for their initial evaluation and sign a consent form. participants who agree to participate in this study will be asked to complete 2 outcomes questionnaires (i.e. spadi, rapa) and katz comorbidity scale. next, patients will be randomly assigned to one of the two groups: regular physical therapy program (pt) or regular pt which add a progressive walking program (pt+). stratified randomization by diabetic status and sex will be used. all participants will be referred to a physical therapy facility according to their preferences and the intervention will be chosen by the treating physical therapist. in pt+ group, participants will be asked to perform free walking at their own pace for 30-45 min, 5 days per week for 6 consecutive weeks and to record their walking date/time on a diary form provided by the research team before commencing the study. participants in pt+ group will also be provided with accelerometer to accurately estimate their physical activity level. outcomes measures for the shoulder functional performance test (primary outcome) will be evaluated at baseline and after 6 weeks. secondary outcomes (shoulder rom, pain and function, muscle strength, and physical activity level) will be evaluated at baseline, at 3 and 6 weeks, and again at 12 weeks after enrollment.

Eligibility criteria:
inclusion criteria: * patients with and without diabetes who have adhesive capsulitis exclusion criteria: * previous shoulder surgery or dislocation * shoulder severe osteoarthritis

Keywords: adhesive capsulitis frozen shoulder diabetes physiotherapy
does modified ultrafiltration affect thromboelastography results?

Conditions: Congenital Heart Disease

Summary: the study is to evaluate the effect of modified ultrafiltration on different components of thromboelastography (teg) in neonates undergoing cardiac surgery using cardiopulmonary bypass.

the study will be performed at advocate children's hospital, oak lawn. all neonates undergoing cardiac operations with cardiopulmonary bypass and modified ultrafiltration will be enrolled. parents will be consented before surgery. after weaning from cardiopulmonary bypass and before starting modified ultrafiltration, a teg sample will be taken. the components studied are reaction time (r), coagulation time (k), angle, maximum amplitude (ma) and whole blood clot lysis index at 30 minutes (ly30). another teg sample will be taken after finishing modified ultrafiltration and before protamine is given. the different components will be compared pre and after modified ultrafiltration. the primary end points are the changes of the different teg components after modified ultrafiltration. the secondary end points are the utilization of different blood products (packed red cells, fresh frozen plasma and platelets transfusion) during and after surgery.

Eligibility criteria:
inclusion criteria: - neonates * congenital heart disease * pediatric cardiac operation with cardiopulmonary bypass * modified ultrafiltration done at the end of cardiopulmonary bypass exclusion criteria: -patients older than 1 month. * cardiopulmonary bypass is not used * modified ultrafiltration is not performed

Keywords: thromboelastography, modified ultrafiltration
evaluation of the effect of yoga training on functional capacity and quality of life in patients with bronchiectasis

Conditions: Bronchiectasis Adult

Summary: evaluation of the effect of yoga training on functional capacity and quality of life in patients with bronchiectasis between the ages of 30-55

investigating the effect of yoga training on functional capacity and quality of life and comparing with previous studies

Eligibility criteria:
inclusion criteria: * diagnosed with bronchiectasis * age 30-55 * not having a known systemic, orthopedic or neurological disease exclusion criteria: * severe heart failure * people who had an acute exacerbation up to three weeks ago will not be included in the study

Keywords: yoga training quality of life functional capacity bronchiectasis
antenatal phenobarbital to prevent neonatal intracranial hemorrhage

Conditions: Infant, Newborn; Infant, Low Birth Weight; Infant, Small for Gestational Age; Infant, Premature; Intracranial Hemorrhages

Summary: this large randomized trial tested whether phenobarbital given to a pregnant woman about to deliver a premature infant would prevent brain injuries in their newborns. women with 24 to 32 week fetuses who were in preterm labor and were expected to deliver within 24 hrs were randomized to phenobarbital or usual care. they were treated until they deliver or the fetus reaches 33 wks gestation. babies were followed until discharge and evaluated at 18-22 mos corrected age for neurodevelopmental outcome.

the administration of phenobarbital to pregnant women before delivery has been thought to decrease the frequency of intracranial hemorrhage in preterm infants. to evaluate this potential neuroprotective therapy further, we determined the effect of antenatal administration of phenobarbital on the frequency of neonatal intracranial hemorrhage and early death. women who were 24 to 33 weeks pregnant and who were expected to deliver their infants within 24 hours were randomly assigned to receive either intravenous phenobarbital (10 mg/kg body weight) or placebo, followed by maintenance doses until delivery or 34 wks gestation. infants less than 34 wks at birth underwent serial cranial ultrasonography to detect the presence of intracranial hemorrhage. the sample size of 1038 pregnancies was based on an intracranial hemorrhage rate of 20 percent in the placebo and less than 12 percent in the phenobarbital group; 90 percent power; a 5 percent two-tailed type 1 error; and an 8 percent noncompliance rate. the twin with the highest grade of intracranial hemorrhage was included. degree of maternal sedation was evaluated after administration of study drug. neonatal ultrasound exams were performed at 3-5 days, 10-14 days, and 38-42 wks postmenstrual age; neonatal medications were recorded during the first week of life; treatments, and outcomes were recorded through death, discharge, or 120 days, whichever occurred first. neurodevelopmental outcome was evaluated at 18-22 months corrected age by certified examiners masked to treatment status.

Eligibility criteria:
inclusion criteria: * admission to a high risk perinatal unit or labor and delivery unit; * 24 to 32 completed weeks gestation; * expected delivery within 24 hrs; * preterm labor or no labor with planned delivery for maternal-fetal indications; exclusion criteria: * anticipated delivery within two hours * multiple congenital or chromosomal abnormalities in the fetus * multiple gestation with more than two fetuses * administration of phenobarbital during the pregnancy * administration of indomethacin within one week before admission * maternal platelet count of less than 100,000 per cubic millimeter

Keywords: nichd neonatal research network extremely low birth weight (elbw) prematurity cerebral hemorrhage phenobarbital pregnancy prenatal care intraventricular hemorrhage periventricular leukomalacia brain injury brain hemorrhage
validation of a diagnostic method for quantification of sleep bruxism

Conditions: Sleep Bruxism; Diagnosis

Summary: this study aims to validate a new diagnostic method for quantification and monitoring of sleep bruxism.

sleep bruxism has characteristically been defined by the american academy of sleep medicine as 'an oral activity characterized by grinding or clenching of the teeth during sleep, usually associated with sleep arousals'. for sleep bruxism diagnosis, to date the polysomnographic recordings represent the highest standard for sleep bruxism diagnosis, but they are concomitantly associated with disadvantages which include technical complexity, limited availability, and the fact that they are time-consuming and cost-intensive. recently, a prototype of a diagnostic plate has been developed which allows a fully-automatic, computer-based quantification of abrasion thereupon for the assessment of sleep bruxism activity. the results of the pilot study were promising, and therefore, the aim of the present study is to refine and validate this new diagnostic method for quantification and monitoring of sleep bruxism.

Eligibility criteria:
inclusion criteria: * patient has signed and understood the approved informed consent form and is able to meet the proposed study proceedings * for the sleep bruxism group: subjects have to fulfill the clinical criteria of the american academy of sleep medicine (sleeping partner's report of grinding sounds during sleep within the last 6 months, plus at least one of the following symptoms: abnormal attrition of the teeth or shiny spots on dental restorations, hypertrophy of the masseteric muscle upon palpation, and/or self-report of muscle fatigue on awakening. in addition to the clinical criteria for sleep bruxism diagnosis, the following polysomnographic criteria have to be present: bruxism episodes/hr \>4, bruxism burst/hr \>25, at least one episode of grinding per sleep period subjects that do not meet any of the clinical or polysomnographic criteria for sleep bruxism were included into the non-sleep bruxism group. exclusion criteria: * current participation in another interventional investigation * cardiac pacemaker * central nervous system and peripheral nervous system disorders * use of sedating medications and/or psychopharmacologically effective drugs * suspected severe psychological disorder (for example schizophrenia) * a lack of german language * drug and/or alcohol abuse * pregnancy or breast-feeding participants of the sleep bruxism group that do not meet any of the clinical or polysomnographic criteria for sleep bruxism were excluded from the sleep bruxism group. participants of the non-sleep bruxism group that fulfill the clinical and/or polysomnographic criteria for sleep bruxism were excluded from the non-sleep bruxism group. further dental exclusion criteria are: * prostheses or extensive prosthetic restorations * dental functional treatment during the last 6 months * gross malocclusion * too many missing teeth that omit fabricating a diagnostic plate * fixed brace * temporomandibular dysfunction requiring treatment

Keywords: sleep bruxism diagnosis validation study assessment
brain activation pattern caused by immersive virtual reality pathfinding task in stroke patients: an fnirs study

Conditions: Stroke; Cognitive Decline

Summary: this is an fnirs study performed to investigate brain activation pattern caused by immersive virtual reality pathfinding task in stroke patients.

this was an initial screening and preliminary intervention study. both healthy subject and stroke patients will be included in this study. brain functional activation of each subject during immersive virtual reality pathfinding task will be evaluated using functional near-infrared spectroscopy (fnirs). cognitive function related scale assessment included mental state examination scale (mmse), montreal cognitive assessment (moca), drawing clock test (dct), shape trials test a.b (stt-a, stt-b), standardized digital modal test (sdmt), auditory verbal learning test-huashan version (avlt-h), and activity of daily living (adl) scale will be used to evaluate the function of each patient. brain activation pattern caused by immersive virtual reality pathfinding task will be identified by by comparing differences in brain activation and brain network connectivity between patients and healthy subjects.

Eligibility criteria:
inclusion criteria: stroke patients: 1. diagnosis of stroke confirmed by neuroimaging (ct or mri) 2. 18-80 years old 3. able to complete the cognitive task 4. able to follow instructions to complete the trial 5. patients who signed an informed consent form. healthy subjects: 1. no abnormalities on cranial 2. 18-80 years old 3. able to complete cognitive task 4. able to follow instructions to complete the trial 5. not taking medications. 6. subjects who signed an informed consent form. exclusion criteria: stroke patients: 1. inability to tolerate the test due to organic diseases 2. serious mental illness that prevents them from cooperating with or tolerating the trial 3. pregnant or lactating women 4. had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction. healthy subjects: 1. inability to tolerate the test due to organic diseases 2. serious mental illness that prevents them from cooperating with or tolerating the trial. 3. pregnant or lactating women 4. had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction

Keywords: stroke virtual reality cognitive impairment fnirs
rhythmic estradiol and bone health

Conditions: Osteoporosis Risk; Menopause

Summary: the goal of this randomized-controlled trial is to compare the effect of rhythmic estrogen treatment to continuous estrogen treatment on bone turnover in healthy postmenopausal women. the main question it aims to answer are: • does rhythmic estrogen lead to increased bone formation in healthy postmenopausal women, compared to continuous estrogen? participants will receive one of the following treatments for a duration of 16 weeks: - rhythmic estradiol: alternating 4-week cycles consisting of transdermal 17-β-estradiol 25μg/24hrs for two weeks, followed by two weeks of transdermal 17-β-estradiol 50μg/24hrs. estradiol therapy will be combined with continuous oral micronized progesterone 100mg once daily. * low-dose continuous estradiol: continuous transdermal 17-β-estradiol 25μg/24hrs, combined with continuous oral micronized progesterone 100mg daily once daily. * standard-dose continuous estradiol: continuous transdermal 17-β-estradiol 50μg/24hrs, combined with continuous oral micronized progesterone 100mg daily once daily. if there is a comparison group: researchers will compare rhythmic estradiol to continuous estradiol to see if rhythmic estradiol improves bone formation in postmenopausal women.


Eligibility criteria:
inclusion criteria: * postmenopausal, defined as final menstrual cycle more than 1 years prior to inclusion and fsh\>30 iu/l * final menstrual cycle \< 10 years prior to inclusion exclusion criteria: * contra-indication for estrogen and/or progesterone therapy * first-grade family member with inherited thrombophilia or history of venous thromboembolism under the age of 60 years * hysterectomy * premature menopause (menopause age \<40 years) * known hypersensitivity to the excipients in the estradiol patch or progesterone capsule * hormonal contraception or hormone replacement therapy use (estradiol with or without progesterone) in the past 12 months * presence or history of any clinically relevant metabolic, endocrinological, hepatic, renal, cardiovascular, gastrointestinal, or respiratory conditions, history of bone disease or bone marrow disease, known vitamin d deficiency (25-oh vitamin d \<30 nmol/l) * recent fracture (\<12 months) * bmi \<20 or bmi ≥30 * use of drugs including herbal medicine known to affect bone metabolism (e.g. corticosteroids) or to interfere with cytochrome p450 enzyme (cyp) pathways. exceptions are occasional use of paracetamol, ibuprofen, acetylsalicylic acid or topical medication
non-comparative study of open abdomen that require the use of negative pressure wound therapy (npwt) for temporary abdominal closure

Conditions: Abdomenal Wound Trauma

Summary: a study in which subjects with a grade 1 or grade 2 open abdomen that require the use of npwt for temporary abdominal closure. subjects will use the npwt system for up to 14 days, with a 21 day post study initiation follow-up assessment for latent complications and mortality.


Eligibility criteria:
inclusion criteria 1. eligible subjects must be properly consented before enrollment. if the subject is incapable of providing consent, emergency consent procedures will be followed, or the subject's legal representative must be asked to provide consent on the subject's behalf, per the irb guidelines. 2. subjects must be at least eighteen (18) yeats of age, or older. 3. males and non-pregnant females. 4. grade 1 or grade 2 open abdomen patients who would benefit from temporary abdominal closure (tac) with topical negative pressure wound therapy (npwt). exclusion criteria 1. grade 3 and grade 4 open abdomens. 2. malignancy in the reference wound bed or margins of the wound. 3. patients with non-enteric unexplored fistulas. 4. high risk for imminent death, as determined by the attending surgeon and principal investigator (pi). 5. pre-existing large ventral hernia. 6. significant loss of abdominal wall fascia as a result of trauma or infection. 7. patients with a known hist01y of poor compliance with medical treatment. 8. patients who have participated in this trial previously and who were withdrawn.
n-acetylcysteine and cocaine

Conditions: Cocaine Abuse; Cocaine Dependence

Summary: this study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence. a rigorous, inpatient human laboratory study will be conducted in which the subjective, physiological and reinforcing effects of cocaine are evaluated during maintenance on placebo and n-acetylcysteine.


Eligibility criteria:
inclusion criteria: * current cocaine use * current cigarette smoker exclusion criteria: * abnormal screening outcome (e.g., ecg, blood chemistry result) that study physicians deem clinically significant * current or past histories of substance abuse or dependence that are deemed by the study physicians to interfere with study completion * history of serious physical disease, current physical disease, impaired cardiovascular functioning, chronic obstructive pulmonary disease, history of seizure or current or past histories of serious psychiatric disorder that in the opinion of the study physician would interfere with study participation will be excluded from participation * females not currently using effective birth control * contraindications to cocaine or n-acetylcysteine * history of schizophrenia in first degree relative
neurologic and neurophysiologic assessment of clinical course in patients with intraspinal processes

Conditions: Tumor

Summary: patients included in the study are treated at the klinik für neurochirurgie usz. the clinical course is documented at paraplegikerzentrum balgrist using validated diagnostic procedures (e.g. scim, asia, neurophysiology). study aims: prognostic value of clinical diagnosis and additional diagnostic procedures? which parameters exhibit optimal prognostic power? differences between tumor/avm associated lesions and traumatic lesions? what can we learn for pathophysiology and treatment? * trial with surgical intervention


Eligibility criteria:
inclusion criteria: * benign intraspinal process (tumor or vascular malformation avm) * primary lesion caudal of the brainstem, affecting c1 * cognitive ability to give written informed consent exclusion criteria: * metastases, malign tumors * traumatic lesions * myelitis, polyneuropathy * disc prolaps

Keywords: intraspinal processes (tumor or vascular malformation avm)
investigation of stem cells in human lipoaspirate

Conditions: Breast Cancer

Summary: the overall purpose of this study is to enhance identification and isolation of adscs and adipocytes, to find the optimum culturing conditions to increase growth and volume of grafts, and to study the effects of cryopreservation on adscs and adipocytes. fat injections are used in aesthetic surgery but tend to disassemble over time. if the investigators can enhance growth and volume of fat in culture, the investigators could use fat grafts in reconstruction of cancer and traumatic injury defects with the patients own cultured fat cells and grafts.


Eligibility criteria:
inclusion criteria: * all adults (18-70 yrs) who have scheduled surgical lipectomy of the hips, abdomen, or thighs are prospective subjects for this study. exclusion criteria: * pregnant women will be excluded to protect the unborn child.

Keywords: adipose-derived stem cells viable adscs apoptosis necrosis cryopreservation
acupuncture and dry needling in peripheral acute fatigue reduction

Conditions: Sedentary Lifestyle; Males

Summary: introduction: neuromuscular fatigue is defined when the muscle becomes incapable of generating muscle power or strength after exercise or long repetitive activities. as well as, the inability to maintain optimum performance and generate maximum voluntary contractions during a physical exercise. when performing physical activity, the body's metabolic response increases proportionally to exercise to satisfy the demands of the human physiological. part of the energy accumulated during exercise is lost to the environment in the form of heat and another part is maintained internally through the physiological control for thermoregulation. in addition, the muscle generates an electric signal important to determine its status regarding power and fatigue. objective: to investigate the reduction of acute peripheral fatigue induced by isometric contractions from acupuncture and dry needling techniques, compared to absolute rest. methods: this is a cross-sectional study and experimental study, with descriptive, analytical and quantitative approach. it follows the consolidated standards of reporting trials (consort) guidelines. the volunteers will be gathered according to the eligibility criteria, and randomly divided in 3 groups: the control group (g1), the volunteers who will remain in prolonged rest; the acupuncture group (g2), in which volunteers will receive six needles in six acupoints in the non-dominant upper limb and the dry needling group (g3), in which the volunteers will receive application of six needles arranged in the non-dominant biceps brachialis.


Eligibility criteria:
inclusion criteria: * male individuals, aged between 18 and 40 years and who are not practicing regular physical activity (sedentary lifestyle). exclusion criteria: * are using food supplementation; * have joint or bone lesions on the limb to be studied; * have problems of metabolic order; * use of hormone therapy; * have had caffeine in the two hours before the study; * have ulceration or wounds in the electrode application region for electromyography; * show absence of myofascial trigger points in areas of dry needling technique; * body mass index below normal values or higher than overweight.

Keywords: muscle fatigue thermography acupuncture dry needling