Kornimate/medical-research-clean huggingface dataset:
blood flow in individuals with down syndrome

Conditions: Down Syndrome

Summary: this study focuses on physiological explanations of difficulties with physical activity and exercise in individuals with down syndrome, by non-invasively examining cardiac output and the regulation of blood flow to working muscles during exercise.

work capacity is an important predictor of declining health or physical function, and of mortality, and is commonly measured as peak oxygen consumption. peak oxygen consumption is very low in individuals with down syndrome, the most prevalent genetic cause of intellectual disability. previous research suggests individuals with down syndrome may experience a double disadvantage when they are exercising: they may not be able to increase cardiac output sufficiently and they may not be able to allocate adequate blood flow to the working muscles. the aim of this research study is therefore to determine the impact of limitations in central and peripheral regulation of blood flow on work capacity in individuals with ds. the results of this project will aid our understanding of the underlying mechanisms and determine the potential to improve health across the lifespan of individuals with down syndrome by tailoring exercise interventions.

Eligibility criteria:
inclusion criteria: * between 18 and 45 years old * generally healthy * sedentary or low-active (defined as being involved in less than 30 minutes of moderately-intense physical activity per day) * additionally for the participants with down syndrome: * diagnosis of down syndrome trisomy 21 and * normal thyroid function or stable thyroid function (and medications) for at least 6 months. exclusion criteria: * atherosclerotic or other vascular disease; * asthma or other pulmonary disease; * hypertension (defined bp \>140/90 mmhg); * blood pressure below 90/60 mmhg; * history of pre-syncope or syncope; * diabetes (defined as hba1c of \>7.5% or use of glucose lowering medication); * severe obesity (defined as bmi \>40); * medications affecting heart rate, blood pressure or arterial function; * anti-inflammatory medication including nsaids; * current smoking and * pregnancy.

Keywords: exercise, blood flow, strength, blood pressure, heart rate,
study comparing corpus callosum atrophy as a marker of later development of cognitive impairment in patients with multiple sclerosis

Conditions: Multiple Sclerosis; Cognitive Impairment

Summary: this study is a cross sectional study of patients diagnosed with clinically isolated syndrome (cis) and rrms, who will undergo a series of tests to assess cognitive impairment, fatigue severity and depressive symptoms. cognitive impairment will be assessed with multiple sclerosis inventory cognition (music) and symbol digit modalities test (sdmt), fatigue severity will be measured with the fatigue scale for motor and cognitive functions (fsmc) and depressive symptoms with the beck depression inventory (bdi). all tests mentioned above are validated for ms patients. in the second step we will use our large longitudinal database of serial mri examinations from which a linear measurement of cci will be retrospectively calculated.


Eligibility criteria:
inclusion criteria: * patients between 18 and 55 years at presentation * diagnosis of relapsing-remitting ms according to revised mcdonald criteria 2005, clinically isolated syndrome suggestive of ms * patients treated with interferon-beta 1b * untreated patients * edss under 5.5 exclusion criteria: * brain pathology other than ms * known history of head trauma * pure spinal manifestation of demyelization * neuromyelitis optica * primary and secondary progressive ms * benzodiazepine intake within the last three months * relapse within the last three months * steroid intake within the last three months * history of severe depressive disorder and/or suicidality, seizure, drug or alcohol abuse * no informed consent * insufficient knowledge of german

Keywords: multiple sclerosis cognitive impairment interferon-beta 1b corpus callosum index
emdr treatment of conditioned nausea and vomiting in cancer survivors

Conditions: Cancer Survivors

Summary: to explore the effectiveness of emdr therapy treatment in reducing symptoms of chemotherapy-induced conditioned nausea and vomiting in (former) patients with cancer.

conditioned nausea and vomiting is a common side effect of anti-cancer treatment, and while strategies like antiemetics exist, their effectiveness is limited. conditioned nausea and vomiting can possibly be addressed through eye movement desensitization and reprocessing (emdr) therapy. emdr therapy is a therapeutic intervention, proven to be effective in the treatment of post-traumatic stress disorder (ptsd), and promising in treating a range of other conditions. at the umcg, emdr therapy is used on a small scale to treat conditioned nausea with positive results, although more rigorous research is needed to fully establish its efficacy. this study aims to explore the effectiveness of emdr therapy treatment in reducing symptoms of chemotherapy-induced conditioned nausea and vomiting in (former) patients with cancer.

Eligibility criteria:
inclusion criteria: * previously pathologically confirmed diagnosis of cancer * previously treated with systemic cancer therapy * persistent complaints (more than 2 months) of conditioned nausea and/or vomiting * able to understand spoken and written dutch * 18 years or older exclusion criteria: * ongoing psychiatric treatment * emdr therapy contraindications (dissociative disorders, personality disorders or severe somatic disorders (e.g. cardiac arrhythmias)) * complex type 2 trauma * known with recent conditions / non-anti-cancer medication which can elicit nausea (e.g. pregnancy or alcohol abuses)

Keywords: emdr nausea vomiting
empagliflozin in treatment of peripheral diabetic neuropathy

Conditions: Diabetic Neuropathy Peripheral

Summary: the aim of the study is to investigate the possible protective effect of empagliflozin in patients with type 2 diabetes mellitus with diabetic peripheral neuropathy and not on sglt2 inhibitors treatment.


Eligibility criteria:
inclusion criteria: patients with type 2 diabetes mellitus (hba1c 7 %- 9%). patients receiving dipeptidyl peptidase-4 inhibitors, metformin ± basal insulin. patients with peripheral neuropathy and not on sglt2 inhibitor treatment. patients aged between 18 years old to 65 years old. exclusion criteria: * breastfeeding female. * pregnant female. * estimated glomerular filtration rate less than 45 ml/minute/1.73 m2. * patients with type 1 diabetes mellitus. * patients with diabetic ketoacidosis. * patients with urinary tract infections. * dehydrated patients till normalized. * lower limb amputation patients. * sglt2 inhibitors hypersensitivity. * severe hepatic patients. * patients on neuroprotective drugs.
three-dimensional printing in cardiac catheterization

Conditions: Satisfaction, Personal

Summary: our purpose is to use 3d printing technology to make human anatomical cardiovascular model, which could apply in the medical education for medical students, in order to improve the effectiveness of the learning process to access.

background： the medical teaching models are expansive and rare. we try to use the 3d printing technology to print cardiovascular model. by using the 3d cardiovascular model, we try to facilitate the leaning curve of understanding the cardiac catheterization. study design： this is a single-site prospective randomized controlled trial of medical education. we expect to enrolled 50 participants. both group will receive same teaching program. traditional education model will be used in control group, and 3d printed model will be used in the experimental group. methods： we use 3d printing technology to create cardiovascular model from the ct scanning, which are drawn by professional 3d drawing staff. the students will be divided into 2 groups: the first group receive lecture/image teaching first then trained by the 3d cardiovascular model; the second group are receiving the reverse order. the satisfaction and the learning outcomes would be evaluated by the questionnaire. effect： we expect the 3d cardiovascular model will bring better learning efficiency and satisfaction. furthermore, we will construct the individual learning project by using the 3d printing model. key words： 3d printing, anatomy instruction, cardiovascular system, cardiac catheterization, high-fidelity simulation.

Eligibility criteria:
inclusion criteria: * medical student, nurse practitioner and resident in fu jen catholic university hospital exclusion criteria: * refused to participate in the study.

Keywords: 3d printed medical education cardiac catheterization heart disease
growth and development of children with inborn errors of metabolism in assiut governorate

Conditions: Inborn Errors of Metabolism

Summary: assessment of growth and development of children with inborn errors of metabolism in assiut governorate

inborn errors of metabolism (iem) are diseases resulting in deficient activity of an individual enzyme, structural protein in an intermediate metabolic pathway, present clinically in a wide variety of ways a ranging from non-specific chronic issues such as childhood delay in attaining development milestones, to acute decompensation. the prevalence of all of inborn errors of metabolism globally is 50.9/100000 live birth, in egypt the prevalence among clinically suspected children is 7.8%. a study conducted in minia governorate (egypt) on children less than 18 years included 67 children showed that 65.7% of children were under height. also a study conducted in upper egypt on 113 pku patients showed that global developmental delay 54.9% was the most frequent presentations of pku children. parents of children with iem face many challenges; as the financial burden and perceived restrictions in all aspects of life, discrimination by society in general, and the main challenge is dietary restrictions. rationale: despite being rare in egypt, iem are regarded as a national priority because of the substantial health burden they place on the growth and development of the affected children, which can range from delayed achievement of developmental milestones to acute decompensation and death. however, there is lack of longitudinal studies in egypt that focus on how iem affect physical development and growth, as well as the difficulties parents encounter while caring for their children and following up with them. to our knowledge, no local studies have been conducted in this field before.

Eligibility criteria:
inclusion criteria: * under five years old children with confirmed diagnosis of iem. * attending the study settings. exclusion criteria: * patients diagnosed since birth with dysmorphic features. * patients diagnosed since birth with congenital anomalies. * patients with other neurological deficits (e.g. cerebral palsy, convulsions, birth anoxia.....)

Keywords: growth development iem assiut
study of a minimally invasive cochlear access for cochlear implantation via a robotic procedure

Conditions: Sensorineural Hearing Loss, Bilateral

Summary: the objectives of this study are to explore the efficacy and safety of a robotic procedure for a minimally invasive cochlear implantation.

the cochlear implant (ci) is a neural prothesis and has been the gold standard treatment for severe to profound sensorineural hearing loss over several decades. the surgical procedure for cochlear implantation surgery aims to atraumatically insert the electrode array of the cochlear implant into the cochlea. however, due to the location of the cochlea inside the skull, the surgeon is required to initially create an access from the surface of the temporal bone to the cochlea (inner ear). in conventional methods, this access is acquired by removal of large portions of the mastoid bone through a wide mastoidectomy and posterior tympanotomy. the outcome and success of the conventional procedure varies due to mainly two factors: surgeon skill and subject anatomical variation. to overcome these variables toward a more consistent and less invasive cochlear implantation surgery, the development of robotic and image guided cochlear implantation has taken place. this study primarily aims to explore the efficacy of the hearo robotic cochlear implantation surgery. primary objective the primary objective of this study is to: • explore the efficacy of a minimally invasive direct cochlear access via the hearo procedure. secondary objectives the secondary objectives of this study are to: * explore the safety of a minimally invasive direct cochlear access via the hearo procedure. * exploratively evaluate the electrode array insertion outcomes through the direct tunnel access.

Eligibility criteria:
inclusion criteria: * subjects scheduled for ci surgery according to clinical routine * subjects who will receive a cochlear implant of the med-el portfolio * signed and dated informed consent form exclusion criteria: * lack of compliance with any inclusion criteria * age under 18 years * pregnancy * distance of the planned trajectory to the facial nerve is \< 0.4 mm as per screening ct scan * distance of the planned trajectory to the chorda tympani is \< 0.3 mm as per screening ct scan * a safe inner ear access cannot be planned for preservation of rw membrane and cochlear structures * individuals where image guidance or robotic procedures are not indicated * individuals who have known allergy to components of the cochlear implant

Keywords: cochlear implant robotic surgery electrode insertion
brain imaging in cerebral venous outflow disturbance

Conditions: Abnormal Cerebral Venous Sinus Morphology; Internal Jugular Vein Stenosis; Image

Summary: cerebral venous outflow disturbance can lead to cerebral hemodynamic disturbances, altered cerebrospinal fluid dynamics, cerebral venous blood stasis, increased cerebral venous pressure and decreased cerebral perfusion, cerebral white matter sparing-like changes, and widening of retinal vessel diameter. these changes are associated with numerous neurological signs and symptoms. therefore, understanding the brain structural and functional changes in patients with cerebral venous outflow disturbance is essential to provide specific imaging evaluation indicators and new diagnosis and treatment methods for patients with cerebral venous return disorders.

cerebral venous outflow disturbance can lead to cerebral hemodynamic disturbances, altered cerebrospinal fluid dynamics, cerebral venous blood stasis, increased cerebral venous pressure and decreased cerebral perfusion, cerebral white matter sparing-like changes, and widening of retinal vessel diameter. these changes are associated with numerous neurological signs and symptoms. a number of central nervous system disorders such as transient global amnesia, transient monocular blindness, primary labor headaches, and even parkinson's have been reported to be closely associated with internal jugular vein stenosis. other common clinical manifestations include sleep disturbances, tinnitus, tinnitus, headache, visual impairment, optic papilledema, hearing loss, cognitive decline and neck discomfort and even autonomic dysfunction. the main objective of this study is to investigate the structural and functional network changes in patients with cerebral venous outflow disturbance using different brain imaging techniques, to clarify the correlation between symptoms of cerebral venous outflow disturbance and brain structure and function; to identify areas with corresponding structural and functional changes in patients with cerebral venous outflow disturbance and or comorbid symptoms, and to provide specific imaging assessment indicators and new diagnostic and treatment tools for patients with cerebral venous outflow disturbance and comorbid symptoms.

Eligibility criteria:
inclusion criteria: * cerebral venous outflow disturbance( moderate to severe stenosis in cerebral venous sinus or intracranial jugular veins ) is confirmed by two of magnetic resonance venography (mrv), computed tomography venography (ctv) or digital subtraction angiography (dsa) * accompanying symptoms such as tinnitus cerebri, cognitive decline, anxiety depression, sleep disorders, etc. for more than 6 months exclusion criteria: * ear primary disease medicine related intracranial hypertension; systemic disease of abnormal metabolism or inflammation; moderate to severe stenosis in intracranial, carotid or vertebral arteries; intracranial lesions.
effect of sulforaphane in broccoli sprouts on nrf2 activation

Conditions: Cystic Fibrosis

Summary: the purpose of this study to investigate the effect of sulforaphane from macerated broccoli sprouts in humans and to evaluate less invasive methods of assessing potential anti-inflammatory drugs in cf.

the hypothesis to be tested is that sulforaphane consumed from macerated broccoli sprouts will activate nrf2, reduce oxidative metabolites and reduce neutrophils in the oral mucosa after 5 days of therapy in healthy volunteers and cf subjects. the study requires 6 brief outpatient visits over 8 days. study procedures include medical history, height, weight, vital signs, blood and urine collection, nasal curettage, saline mouthwash, and ingestion of broccoli sprouts (100 gm of 3 to 5 day old raw broccoli sprouts once daily for 5 consecutive days).

Eligibility criteria:
inclusion criteria: * healthy volunteers and patients with cystic fibrosis ≥ 18 \< 50 years of age * healthy volunteers must be in general good health as determined by a medical history * cf subjects must have a documented diagnosis of cf (positive sweat chloride ≥ 60 meq/liter, by pilocarpine iontophoresis) and/or a genotype with two identifiable mutations consistent with cf accompanied by one or more clinical features with the cf) phenotype * cf subjects must have a baseline fev1 percent predicted \> 50% (in the last year, obtained from medical record) * cf subjects must be clinically stable: free of any acute illness for \> 14 days cf subjects must not have been prescribed any new systemic antibiotics for the 14 days prior to enrollment * ability to provide written informed consent * ability to adhere to the protocol exclusion criteria: * use of nsaids (e.g., ibuprofen) or corticosteroids including inhaled steroids for the 4 weeks prior to enrollment * active gingival disease (active tooth or gum disease) * history of nephrolithiasis or cholelithiasis * allergy to broccoli * any chronic condition that compromises the participant as determined by medical history * pregnancy * inability to tolerate the study procedures * cf subjects: infected with b. cepacia

Keywords: broccoli sprouts sulforaphane triterpenoid nrf2 activation cystic fibrosis healthy volunteers anti-inflammatory
tear film break-up time after instillation of artificial tears

Conditions: Keratoconjunctivitis Sicca

Summary: this study is an exploratory trial evaluating the tear film break-up time after a single eye drop instillation of over-the-counter artificial tears. the primary hypothesis is that tear film break up time will be greater for test than control eye.

subjects with varying degrees of dry eye syndrome were enrolled in a randomized, controlled, double masked, single site study. a new formulation of an artificial tear containing glycerin 1% as an active with polylysine-graft-polyethylene glycol as an excipient was compared against a leading commercial product with propylene glycol (0.3%) and polyethylene glycol (0.4%) as active ingredients with hydroxypropyl-guar as a gelling agent. the primary outcome was a comparison of tear film stability after eye drop instillation.

Eligibility criteria:
inclusion criteria: * age \> 18 years * symptoms of dry eye * no other history of ophthalmic problems exclusion criteria: * use of any ocular lubricant or ointment in the past 36 hours * use of contact lenses or excessive eye lid cosmetics on the study day

Keywords: ocular lubricants
study to assess the safety and tolerability of iv tonapofylline in subjects with acute decompensated heart failure (adhf) and renal insufficiency

Conditions: Renal Insufficiency; Congestive Heart Failure

Summary: the purpose of the current study is to assess the safety and tolerability of intravenous tonapofylline.


Eligibility criteria:
inclusion criteria: * previous diagnosis of heart failure. * must have adhf, requiring hospitalization, with clinical evidence for volume overload exclusion criteria: * history of an allergic reaction to any xanthine-containing substance. * history of seizure * history of stroke * myocardial infarction * uncorrected hemodynamically significant primary valvular disease or known obstructive or restrictive cardiomyopathy. * serious systemic infection * major surgical procedures within 30 days * acute coronary syndrome * cardiogenic shock * baseline body weight \>150 kg * participation in any other investigational study of drugs or devices within 30 days prior to screening * nursing mothers, pregnant women, or women planning on becoming pregnant during the study * presence of any clinically significant condition that might interfere with optimal safe participation in this study

Keywords: renal insufficiency diuretic congestive heart failure acute decompensated heart failure
coronal and radicular caries prevalence and related risk factor in diabetic patient

Conditions: Caries,Dental; Caries Root; Diabetes Mellitus, Type 2

Summary: this study aims to investigate the prevalence and risk factors of coronal and radicular caries in middle-aged individuals with type 2 diabetes. it focuses on how poor blood sugar control, reduced saliva production, increased plaque accumulation, and periodontal disease contribute to a higher risk of dental decay in this population. the study examines the relationship between glycemic control (e.g., hba1c levels) and the severity of caries, as well as the impact of diabetes-related changes in oral health, such as gum recession and dry mouth, on the development of both coronal and radicular caries. the findings could inform preventive strategies and dental care guidelines tailored for diabetic patients.


Eligibility criteria:
inclusion criteria: 1. patient whose age between 30-65 2. diabetic patients 3. patient consulting in the outpatient clinic 4. co-operative patient 5. males \& females 6. egyptian exclusion criteria: 1. patients under or over this age group 2. lack of compliance 3. disabilities 4. pregnant women
effects of ketogenic diet in body builders

Conditions: Diet, Healthy; Body Weight

Summary: the study sought to investigate the influence of 8 weeks of a very low carbohydrate ketogenic diet on body composition, muscle strength, muscle area and blood parameters in competitive natural body builders.

nineteen natural body builders were randomly assigned to a ketogenic diet (kd) group or to a normal diet group (nd) with a traditional meal pattern. the two diets were isocaloric and included the same amount of protein per kg of body weight; but differed in the distribution of fats and carbohydrates; the latter were kept below 5% daily (less than 50g/day) in the kd group while represented 55% of the caloric intake in the wd group during the experimental period, training loads were similar in the two groups. athletes were tested before and after 8 weeks of the intervention. body composition , basal metabolism, muscle strength and blood parameters were measured.

Eligibility criteria:
inclusion criteria: * at least 5 years of training experiences * competing in recognized body building category exclusion criteria: * adherence to special diets * use of nutritional supplements (except a daily multivitamin-mineral and/or protein supplement) * use of medications (steroids) * diabetes or metabolic diseases

Keywords: ketogenic diet body builders athletes body composition hormones