Kornimate/medical-research-clean huggingface dataset:
adherence to cpap in patients with osa. ten year follow up

Conditions: OSA; Adherence, Patient; CPAP

Summary: the management of osa is aimed to improve symptoms and mitigate reduce other health consequences. continuous positive airway pressure (cpap) is the recognized treatment for osa, able to reverse the pathophysiology of osa and improving sleep continuity, resulting in improvements in daytime sleepiness and quality of life (qol). however, low adherence to this treatment reduces the potential to achieve these benefits. the aim of this real life retrospective observational study was to assess the adherence to cpap at 12 month and 10 years. the investigators evaluated also predicitve factors of adherence.

methods the protocol was approved (2215 ce, june, 19, 2018) by the ethical committee of the istituti clinici scientifici (ics) maugeri, pavia, italy. all patients at admission to the scientific institute of tradate gave the informed consent to the scientific use of their data. study participants this study was conducted on a database of patients' discharge records, available between august, 2006 and december, 2009. adaptation to cpap: titration of cpap was performed either by full-night manual titration according to the aasm guidelines or by automatic titration with auto-set systems. further 4 day-time hours of adaptation were performed along two days. patients underwent also four face to face sessions with the respiratory therapist, for feed-back of adaptation, optimal comprehension of procedure of cpap management. the presence of a caregiver (if any) was strongly suggested. statistical analysis an ad hoc electronic form was created to collect all study variables. qualitative variables were described with absolute and relative (percentages) frequencies, whereas quantitative variables were summarized with means (standard deviations) or medians (interquartile ranges) based on their normal distribution, respectively. in-between comparison for qualitative and quantitative variables was performed with the chi-squared or fisher exact test when appropriate, and student t or mann-whitney test in case of parametric or non-parametric distribution, respectively. comparison of the temporal variation of continuous variables for the same group was assessed with anova or friedman's test, depending on their normal distribution. uni- and multi-variable logistic regression analysis was performed to assess which covariates could be associated with the adherence to cpap. a two-tailed p-value \<0.05 was considered significant. all statistical analyses were carried out using the statistical software stata version 15 (statscorp, texas).

Eligibility criteria:
inclusion criteria: * diagnosis of osa * admitted for adaptation to cpap exclusion criteria: * other sleep related diseases * concomitant lung or thoracic diseases (including chronic respiratory failure requiring long term oxygen therapy) * major comorbidities (e.g. psychiatric conditions, cancer, end-stage renal failure) * familiar conditions preventing long-term home cpap * patients already treated with cpap
effects of nordic walking in parkinson disease patients

Conditions: Parkinson Disease; Parkinson Disease 10

Summary: the aim of this study was to evaluate and compare the effects of a nordic and free walking training program on clinical, functional and biomechanical parameters of gait, in people with pd. outcomes: motor symptoms: staging and severity of pd, balance, walking functional mobility, self-selected walking velocity, and rehabilitation index. non-motor symptoms: cognitive function, depressive symptoms, and quality of life (ql). outcomes biomechanics: kinematic parameters (spatiotemporal and dynamic stability of walking) and neuromuscular parameters (amplitude of the electromyography signal, initial and final activation threshold, activation time and co-contraction index, of the following muscles: vastus lateralis (vl), biceps femoris (bf), tibialis anterior (ta), gastrocnemius medialis (gm).

introduction: changes in clinical, functional and biomechanical parameters of gait are remarkable features in parkinson's disease (pd). such changes are disabling for the performance of daily living activities (dlas) as they represent a high risk of falls and impair quality of life (ql) in this population. although exercise is recommended as an effective model of therapeutic intervention, to minimize the symptoms of this disease, little is known about the effects of nordic walking on motor and non-motor symptoms in patients with pd. purpose: the aim of this study was to evaluate and compare the effects of a nordic and free walking training program on clinical, functional and biomechanical parameters of gait, in people with pd. experimental design: randomized controlled clinical trial (rct). study site: physical education school of the federal university of rio grande do sul and the clinical hospital of porto alegre, in porto alegre, rio grande do sul, brazil. methods: the sample comprised 33 participants, aged above 50 years, of both sexes, with a clinical diagnosis of idiopathic pd, with the staging of 1-4 in the hoehn and yahr scale (h\&y). the participants received two types of intervention: nordic walking training program (nw, n = 16) and free walking training program (fw, n = 17), during six weeks. aiming to evaluate the effects of the training program, the participants underwent the tests in the following period: pre-training + pre-familiarization (t1); post-familiarization + pre-training (t2); post-training (t3).

Eligibility criteria:
inclusion criteria: volunteers aged over 50 years, of both sexes, with a clinical diagnosis of idiopathic pd and staging between 1 and 4 in hoehn and yahr scale (h\&y). - exclusion criteria: * show chronic pain or presence of a migraine or nausea in daily life; * history of labyrinthitis; * deep brain stimulation (dbs); * the frequency of training below of 75%.

Keywords: functionality gait kinematics electromyographic activity depressive symptoms quality of life
γδt cell infusion to prevent relapsed/refractory leukemia rescue relapse

Conditions: Leukemia, B-cell

Summary: safety and effectiveness of donor γδt cell infusion to prevent relapsed/refractory leukemia rescue relapse after allogeneic hematopoietic stem cell transplantation

γδt cells belong to the innate immune system and have a powerful anti-tumor effect. leukemia patients transplanted with allogeneic hematopoietic stem cells have an important role in controlling leukemia recurrence. although adoptive immunotherapy using in vitro expanded γδt cells has achieved significant results in patients with solid tumors, infusion of donor γδt cells in leukemia patients undergoing allogeneic hematopoietic stem cell transplantation to prevent leukemia recurrence has not been reported. . this clinical study intends to initially observe the safety and effectiveness of donor γδt cell infusion to prevent recurrence/refractory leukemia salvage allogeneic hematopoietic stem cell transplantation to further improve the transplantation effect of these patients

Eligibility criteria:
inclusion criteria: * acute leukemia patients undergoing salvage allogeneic hematopoietic stem cell transplantation * age 10-65,any gender * expected lifetime\>3months * ecog 0-2 * dsa negative * successful granulocyte implantation * liver and kidney function, heart and lung function meet the following requirements:①creatinine≤1.5 uln；②alt/ast ≤5 uln； ③baseline oxygen saturation≥92%； ④left ventricular ejection fraction≥50% * female subjects with fertility who had a negative pregnancy test within 48 hours before the infusion and were not breastfeeding; all subjects with fertility potential before enrolling in the study and throughout the study period until the last infusion within 3 months, take adequate contraceptive measures * signing informed consent patients must be able to understand and be willing to participate in this study, and sign informed consent at the same time exclusion criteria: * donor hbsag or hbcab positive and hbv dna titer test is not within the normal reference value; donor or patient hcv antibody positive and peripheral blood hcv rna positive; donor or patient hiv antibody positive; donor syphilis test positive * active central nervous system disease * bmi index\>35 * allergic to dmso * graft-versus-host disease * septic shock * systemic steroid therapy is required during cell infusion or cell collection, or there are conditions that researchers believe may require steroid therapy during blood collection or during infusion. in addition to cell collection or infusion, steroids for disease treatment are allowed, and inhaled steroids or hydrocortisone are also allowed for physiological replacement therapy in patients with adrenal insufficiency * participated in another clinical trial within 4 weeks before enrolling in the study, or intend to participate in another clinical trial throughout the study * according to the judgment of the investigator, it does not meet the situation of cell preparation * circumstances considered by other researchers to be inappropriate

Keywords: γδt leukemia
evaluation of the immediate effect of acupuncture on the upper trapezius muscle in patients with nonspecific neck pain.

Conditions: Nonspecific Neck Pain

Summary: the aim of the proposed study is to evaluate the immediate effect of acupuncture on pain, cervical range of motion and electromyographic activity of the upper trapezius muscle in patients with nonspecific neck pain.twelve patients with nonspecific neck pain and 12 healthy subjects will be enrolled in a randomized, single-blind, crossover study. each patient will receive two forms of treatment in random order: a single session of traditional acupuncture and sham acupuncture. to eliminate carry-over treatment effects, a one-week wash-out period will be respected between sessions. surface electromyography will be used to determine motor control in the upper trapezius muscle before and after treatment. the outcome measures in the group with neck pain will be a numerical pain rating scale (range: 0 \[no pain\] to 10 \[maximum pain\]), documentation of the pain area on a body chart and cervical range of motion. linear regression analysis will be applied for each individual to investigate associations between the semg variables and force (excluding the sixth step). the slopes of the regression lines will be used to measure the sensitivity of the semg variables regarding changes in force. the shapiro-wilk test will be used to test the normality of the data distribution regarding rms and mdf values in the third and sixth step of the step contraction. paired samples (student's t-test or wilcoxon test) will be used to test differences between third and sixth contraction step. a mixed linear model will be used to analyze and compare the semg data during sustained contraction (five steps) between pre-acupuncture (emg-1) and post-acupuncture (emg-2) evaluations. these comparisons will demonstrate whether acupoints te-5 and li-11 affect the activity of the upper trapezius muscle, as hypothesized. the pain (nrs, ppt and area) and cervical rom data collected during the four evaluations will also be compared using a mixed linear model. the statistical package for social sciences (spss, version 19.0 for windows) will be employed for the statistical analysis, with the level of significance set to 5% (p \< 0.05).


Eligibility criteria:
inclusion criteria: * 18 to 40 years * male and female volunteers exclusion criteria: * history of neurological disorders * neck surgery * chronic neck pain resulting from a traumatic incident * chronic musculoskeletal condition * medical diagnosis of fibromyalgia; systemic disease * connective tissue disorder * non-tolerance of needles; current pregnancy * having undergone physical therapy use of analgesic, muscle relaxant.

Keywords: physical therapy modalities neck pain acupuncture
the effects of a digital application for gdm management in improving patients' compliance

Conditions: Gestational Diabetes; Pregnancy in Diabetic

Summary: gestational diabetes mellitus (gdm) is the most prevalent complication in pregnancy. patients' follow-up and treatment is performed in specialized gdm clinics that teach and support women in implementing lifestyle changes, blood glucose self-monitoring, and nutritional and pharmacologic therapy. recently, mobile health (mhealth) applications have been introduced as a resource to improve self-management and follow-up among pregnant women. the proposed study will examine the efficacy of the gdm management mhealth application in improving patients' compliance and satisfaction, glycemic control, and pregnancy outcomes. a multicenter randomized controlled trial of women with gdm treated in the gdm clinics. women will be randomly allocated to a research group that will use the gdm application and a control group that will receive regular follow-up without the gdm application. the primary outcome is patient compliance, defined as the actual blood glucose measurements/instructed measurements ×100. secondary outcomes include glycemic control parameters, and maternal and neonatal complications.


Eligibility criteria:
inclusion criteria: * pregnant women diagnosed with gdm from 13.0 gestational week * recruitment until 34.0 gestational week * 18 years old and older * singleton pregnancy exclusion criteria: * women with pre-gestational diabetes mellitus * multiple pregnancy * women without a smartphone that can support the gdm application * refusal to participate

Keywords: gestational diabetes pregnancy mobile-health application compliance complications
propionibacterium acnes in shoulder arthroplasty

Conditions: Propionibacterium Acnes

Summary: the investigator's plan to determine whether pre-operative skin preparation with hydrogen peroxide alters rates of p acnes culture positivity. they hypothesize that pre-operative skin preparation with hydrogen peroxide will reduce rates of p acnes culture positivity.

over half of all post-operative infections after shoulder arthroplasty are due to propionibacterium acnes. even in apparently "aseptic" revisions, nearly all cultures taken at the time of revision surgery are positive for p acnes, and thus low-grade infection with this bacteria may be a more common cause of failure than previously suspected. current antibiotic prophylaxis methods are ineffective against p acnes. despite intravenous cefazolin, p acnes can be cultured from the glenohumeral joint in 42% of patients undergoing primary total shoulder arthroplasty. despite skin preparation with chlorhexidine, p acnes can be cultured from 73% of portal sites in arthroscopy. p acnes is further insensitive to alcohol. dermatologists have long been treating p acnes as it is a primary cause of acne vulgaris. one of the most popular and effective treatments for acne vulgaris is topical benzoyl peroxide. a prior prospective clinical trial demonstrated that adding topical 5% benzoyl peroxide 48 hours prior to surgery reduced p acnes culture positivity to 6%. the downside of this treatment is that it must be applied by the patient, at home, for 48 hours prior to surgery. an additional downside is that benzoyl peroxide is a skin irritant that not all patients tolerate. in aqueous environments, benzoyl peroxide rapidly decomposes into benzoic acid and hydrogen peroxide. benzoic acid is a skin irritant and hydrogen peroxide is the active ingredient. benzoyl peroxide is used instead of hydrogen peroxide because hydrogen peroxide breaks down into water and oxygen when exposed to light. recently, stabilized forms of hydrogen peroxide have been developed and have been demonstrated to be equally effective to benzoyl peroxide in the treatment of acne vulgaris. one potential reason for hydrogen peroxide's efficacy against p acnes is that it is absorbed into the skin, addressing p acnes residing in sebaceous glands. to date, no studies have examined whether the addition of hydrogen peroxide to pre-operative skin preparation can reduce intra-operative p acnes culture positivity.

Eligibility criteria:
inclusion criteria: * patients undergoing primary shoulder arthroplasty exclusion criteria: * patients with prior shoulder surgery. * patients with a symptomatic infection or history of infection, recent antibiotic use (within six weeks), or with clinical signs of infection such as an elevated esr, crp, positive aspiration cultures, or positive biopsy. * patients with a known hypersensitivity to hydrogen peroxide.

Keywords: hydrogen peroxide propionibacterium acnes shoulder arthroplasty
the effect of baduanjin on shoulder function in maintenance hemodialysis patients

Conditions: Hemodialysis Complication; Shoulder Joint Disorder; CKD-MBD

Summary: the aim of this study is to examine the effect of 18-month baduanjin exercise on shoulder joint function in maintenance hemodialysis (mhd) patients. 60 mhd patients aged 18-75 will included in this study and randomly divided into two groups (intervention group and control group). the intervention group will be led by a professional person and underwent baduanjin exercise three times a week before hemodialysis. the control group maintained routine treatment and daily activities.

the aim of this study is to observe the therapeutic effect of baduanjin on improving shoulder joints in mhd patients. a total of 60 maintenance hemodialysis patients will be included and randomized into an intervention group of 30 cases and a control group of 30 cases. the intervention group underwent a 30 minute baduanjin exercise under the guidance of a professional doctor before the dialysis day, including a 5-minute warm-up exercise, a 20 minute baduanjin exercise, and a 5-minute relaxation exercise. the intervention group practice baduanjin three days a week, while the control group maintain routine treatment and daily activities. measure the indicators of each group at baseline, months 6, 12, and 18. the evaluation of shoulder joint function is based on the shoulder constant score (which includes three dimensions: pain, daily living activities, and active range of motion); the quality of life score is based on the sf-12 score, and the emotional score is based on the anxiety and depression scale.

Eligibility criteria:
inclusion criteria: * age\>18 years old, ≤ 75 years old * maintenance dialysis treatment for ≥ 3 months, three times a week * the six minute walking experiment were used to screen patients for suitability for baduanjin * right handedness, fistula in left hand exclusion criteria: * the vascular pathway is a tunnel catheter with a polyester sheath * the vascular pathway is a right arteriovenous fistula * known infectious diseases * individuals with primary or secondary muscle diseases, mental abnormalities, lack of autonomous behavior ability, and lack of cooperation with clinical observation and treatment.
evaluation of diagnostic value of molecular markers in renal cancer

Conditions: Kidney Neoplasms

Summary: renal cancer is frequent and its diagnosis mainly dependant on imaging. more than 50% of renal tumors are currently diagnosed without symptoms. however, 20% of small solid tumors are benign and this percentage is much higher in atypical cystic tumors bosniak ii and iii, where 76% and 59% are benign respectively. determining the malignancy by imaging in these cases is difficult and sometimes impossible. the fine needle aspiration (fna) cytology or biopsy is necessary. the diagnostic sensitivity and specificity with biopsy are high, but the potential tumor contamination is a major risk. the fna cytology is simple and safe, but its sensitivity is about 50%. we are conducting a multicentric prospective study to add the molecular markers in fna cytology as a new diagnostic method in imaging-indeterminate renal tumors. four molecular markers including mn/ca9, vimentin, kit, and s100a1 will be studied. these four markers have been reported to have a differential diagnostic value in renal tumors. mn/ca9 and vimentin are often found in conventional renal cancers. kit is frequently expressed in renal oncocytomas and chromophobe renal cancers. s100a1 may further distinguish renal oncocytoma from chromophobe renal cancer. these markers will be analyzed by real time polymerase chain reaction (rt-pcr). the aim of this study is to evaluate the diagnostic performance of the association cytology-molecular markers in imaging-indeterminate renal tumors (small solid tumors and cystic tumors ≥ bosniak iii). about 156 patients will be included in five french clinical centers including saint-etienne, marseille, grenoble, toulouse, and nancy. the expected results will improve the preoperative diagnostic accuracy in renal tumors.


Eligibility criteria:
inclusion criteria: * clinical diagnosis of kidney tumor \< 4 cm * cystic kidney tumor (bosniak \> iif) * consent signed exclusion criteria: * benign tumor confirmed * impossibility to do abdominal pelvic ultra-sound or abdominal thoracic scanner * contraindication for renal puncture

Keywords: kidney tumor molecular markers cytology histology cystic kidney tumor
the effect of coffee after resection of small bowel

Conditions: Postoperative Ileus

Summary: post-operative ileus ("post-op ileus") is a condition which can occur after surgery. this means that the bowels stop working correctly and food and liquids will not pass through in the normal manner. post-op ileus can be uncomfortable and require a longer hospital stay until the bowels begin to function correctly again. currently there are no effective methods for preventing post-op ileus. some studies suggest there is a benefit from drinking coffee following colon or gynecological cancer surgeries with very little risk. however, the effects of coffee following small bowel surgery have not been studied. this randomized, controlled trial will compare the outcomes of patients who receive coffee during their hospital stay after small bowel surgery to similar patients who receive warm water. about 60 patients will be in each group. the main outcomes are time until the nasogastric tube is removed and length of hospital stay.


Eligibility criteria:
inclusion criteria: * patients undergoing small bowel resection. can be elective, urgent or emergent. exclusion criteria: * patient with atrial fibrillation who is considered a non-coffee drinker (drinks coffee less than 3 days per week over the last 4 weeks) * patients undergoing colon resection without removal of any portion of small bowel.
fexofenadine versus gabapentin for uremic pruritus in patients on regular hemodialysis

Conditions: Uremic Pruritus; Chronic Kidney Disease-associated Pruritus; Hemodialysis; End-stage Renal Disease; Renal Replacement Therapy; ESRD

Summary: several studies investigated the effectiveness of gabapentin in uremic pruritus (up). no previous studies investigated the use of fexofenadine in up. the aim of this trial is to assess the safety and possible efficacy of fexofenadine in patients with up.

a randomized controlled single center parallel study, that will recruit 60 participants with end stage renal disease (esrd) on regular hemodialysis (rhd) with uremic pruritus (up). patients will be randomized to either fexofenadine (60 mg orally once daily), or gabapentin (100 mg orally after each dialysis session, "thrice weekly", with titration according to response to 100 mg orally once daily). participants will continue treatment for 3 months.

Eligibility criteria:
inclusion criteria: * age ≥ 18 years old. * esrd on regular hemodialysis. * moderate and severe uremic pruritus as assessed by visual analogue scale. * able to provide an informed consent. exclusion criteria: * age \&lt; 18 years old. * patients not on regular hemodialysis. * pruritus due to other cause. * cancer patients. * pregnancy or breastfeeding. * patients with history of substance abuse. * patients with myasthenia gravis. * patients who refuse or are unable to provide an informed consent.

Keywords: pruritus hemodialysis esrd rhd fexofenadine gabapentin interleukin 6 il-6 substance p sp ckd-ap chronic kidney disease-associated pruritus uremic up uremic pruritus end-stage renal disease