Kornimate/medical-research-clean huggingface dataset:
efficacy of one or two botulinum toxin injections in the treatment of chronic lateral epicondylalgia: a retrospective study (epitox)

Conditions: Lateral Epicondylitis

Summary: despite being a self-limiting injury, lateral epicondylitis (le) can be difficult to manage. in cases of refractory le, conservative treatment fails and symptoms persist over 6 months. previous studies have investigated the role of botulinum toxin type a (bont-a) injections in le with controversial results. there is some evidence that repeating the bont-a injection could be beneficial for refractory cases. the objective is to assess the success rate of one or two bont-a injections for refractory le.


Eligibility criteria:
inclusion criteria: lateral epicondylitis at least one botulinum injection exclusion criteria: * none
development of polygenic risk scores in colon cancer patients through the study of ancestry and diversity in genetic maps of the brazilian population - origem project

Conditions: Colo-rectal Cancer; Polygenic Risk Score; Somatic Mutation; Hereditary Cancer; Germline Mutations; Cancer Predisposition Syndrome

Summary: development of a polygenic risk score based on somatic and germline genetic information from patients with colorectal cancer

colorectal cancer (crc) is the third most common cancer diagnosed in both men and women. approximately 70% of crc cases originate from spontaneous point mutations in oncogenes, tumor suppressor genes, and genes related to dna repair mechanisms (nigin et al., 2023). the remaining 30% result from hereditary mutations, of which 5-6% involve high-penetrance genes. genetic predisposition due to pathogenic germline variants in high-risk cancer-associated genes has been implicated in 2-8% of all crc cases, increasing to 6-10% when considering pathogenic mutations in both high- and moderate-penetrance genes. for individuals with certain hereditary cancer syndromes, the risk of developing colorectal cancer can reach 50-80% in the absence of endoscopic and/or surgical intervention. therefore, characterizing high-, moderate-, and low-penetrance genes within a population is crucial for understanding hereditary tumorigenesis and guiding more cost-effective screening strategies. genetic studies comparing genomes from populations of different ethnic backgrounds have demonstrated that ancestry plays a significant role in genetic predisposition to crc. given the high level of genetic admixture in the brazilian population, studies focused solely on populations of european ancestry fail to provide a representative model for application in highly admixed populations like brazil. in this context, the present study aims to utilize next-generation sequencing (ngs) in a cohort representative of the brazilian population with crc and controls to develop a polygenic risk score (prs). this score could impact cancer screening and prevention strategies, as well as genetic counseling for patients and their families. the hypothesis is that genetic mapping-including ancestry, germline, and tumor genetic variability-in brazilian colorectal cancer patients will provide valuable data for developing a prs that may eventually guide more targeted and cost-effective screening strategies for our population.

Eligibility criteria:
inclusion criteria: * \> 18 years; * histologically confirmed diagnosis of colorectal cancer; * have available tumor material for somatic sequencing, obtained from biopsy or routine surgery; * sign the informed consent form (icf) for the study. exclusion criteria: • pregnants
comparison among the effects of blood flow restriction training and conventional exercise in knee osteoarthritis.

Conditions: Osteoarthritis, Knee; Hypertrophy

Summary: the main objective of the study is to compare the effects of blood flow restriction training vs. traditional exercises on knee pain , knee functional disability and on quadriceps strength in patient with knee osteoarthritis.

osteoarthritis is a degenerative disease affecting the most commonly weight bearing joint.the common form of arthritis is osteoarthritis (oa) causing structural changes in the joint. age is a common factor affecting the strength and muscle mass.worldwide there is a drastic increase of osteoarthritis in the older population. in the past 20 years the prevalence of knee pain increased and reached up to 50% in the older population. the most common oa affecting lower extremity is in the knee joint.majority of the people affected by knee oa are the older population. knee joints being the most weight bearing joint affected in oa causing pain , limiting function and mobility.mobility and function may be affected in osteoarthritic population usually experience pain and stiffness. the main objective of this study is to compare the effects of blood flow restriction training vs conventional treatment exercises on knee pain, functional disability and quadriceps strengthening. the main purpose of this study is to improve the muscular strength of lower limbs which are being affected in a disease osteoarthritis in the adult population.

Eligibility criteria:
inclusion criteria: * pain : subjects having unilateral or bilateral pain * pain type : subjects having chronic pain * includes diagnosed cases of knee osteoarthritis * grades 2-3 according to the kellgren and lawrence method of grading * includes knee osteoarthritis patients with lateral tracking of patella which will assessed through q angle test exclusion criteria: * any other orthopaedic or neurological condition of hip and knee * sign and symptoms of lower motor neuron disease * current use of medication * radiculopathy * fracture * malignancy * thromboembolism * decreased range of motion

Keywords: osteoarthritis blood flow restriction quadriceps resistance training
nhfov vs. ncpap as a primary treatment to neonatal respiratory distress syndrome(nrds)

Conditions: Preterm Infants

Summary: the investigators compared advantages and disadvantages of two forms of noninvasive respiratory support -noninvasive high-frequency oscillatory ventilation (nhfov) or nasal continuous positive airway pressure (ncpap) -as a primary mode of ventilation in premature infants with rds．

background: invasive mechanical ventilation is associated with development of adverse pulmonary and non-pulmonary outcomes in very low birth weight infants. various modes of non-invasive respiratory support are being increasingly used to minimize the incidence of bronchopulmonary dysplasia (bpd). the aim of this trials to compare the effect of noninvasive high-frequency oscillatory ventilation (nhfov) and nasal continuous positive airway pressure (ncpap) in preterm infants with respiratory distress syndrome (rds) as a primary noninvasive ventilation support mode. methods/design:in this multicenter, randomized, controlled trial, 300 preterm infants at gestational age (ga) less than 34 weeks with a diagnosis of rds will be randomized to nhfov or ncpap as a primary mode of non-invasive respiratory support. study will be conducted in 18 tertiary neonatal intensive care units in china. the primary outcome is the need for invasive mechanical ventilation (imv)during the first 7 days after enrollment in preterm infants randomized to the two groups. the secondary outcomes include days of hospitalization, days on noninvasive respiratory support, days on imv, days on supplemental oxygen, mortality, need for surfactant, incidence of retinopathy of prematurity(rop) and bronchopulmonary dysplasia(bpd), occurrence of abdominal distention, air leaks, intraventricular hemorrhage (ivh ≥ grade 3) and necrotizing enterocolitis (nec\> ii stage). other secondary outcomes include scores of bayley scales of infant development at 2 months and 2 years of corrected age.

Eligibility criteria:
inclusion criteria: (1)gestational age (ga) is from 26 to 34 weeks; (2) diagnosis of rds. the diagnosis of rds will be based on clinical manifestations (tachypnea, nasal flaring and or grunting) and chest x-ray findings; (3) rds silverman score\>5; (4) informed parental consent has been obtained. exclusion criteria (1) severe rds requiring early intubation according to the american academy of pediatrics guidelines for neonatal resuscitation7; (2)major congenital malformations or complex congenital heart disease; (3) group b hemolytic streptococcus pneumonia, septicemia, pneumothorax, pulmonary hemorrhage; (4) cardiopulmonary arrest needing prolonged resuscitation; (5) transferred out of the nicus without treatment.

Keywords: nrds nhfov ncpap preterm infants
antibiotic therapy for hospital-acquired infections in icu patients

Conditions: Infection in ICU

Summary: antibiotic therapy for hospital-acquired infections in icu patients. a prospective, observational, multicenter study (anthicus).


Eligibility criteria:
inclusion criteria: * patients with hospital-acquired infections and hospitalised in the icu at one moment of their hospital stay * hospital-acquired infections accounting for eligibility are: * nosocomial pneumonia (including ventilator-associated pneumonia) * bacteremia * intra-abdominal infections * urosepsis

Keywords: antibiotic, icu, hospital acquired infection.
wellness and quality of life perceptions of people with traumatic brain injury

Conditions: Brain Injuries, Traumatic

Summary: telerehabilitation is a service delivery method that has grown substantially in recent years. it has both advantages and disadvantages in comparison to clinic-based services. for example, telerehabilitation is advantageous for people residing in locations in which specialized rehabilitation services are scarce; however, it has the disadvantage of being dependent on reliable internet connections that are not available in all locations. also, some people prefer the privacy afforded by receiving treatment in their home, but other people prefer the interaction with other clients with similar challenges afforded by attending sessions in clinic-based settings. other questions about advantages and disadvantages of telerehabilitation remain unexplored. one such question is the focus of this research and concerns the effect of receiving post-acute telerehabilitation services versus clinic-based services on the general well-being and quality of life experienced by people with traumatic brain injury. the study purpose is to compare changes in wellness and quality of life occurring over a four-month period during which people with traumatic brain injury receive post-acute services either via telerehabilitation or at an outpatient facility.


Eligibility criteria:
inclusion criteria: * sustained traumatic brain injury * receiving inpatient services at quality living, inc., omaha, ne * fluent in english * scheduled to receive either telerehabilitation or clinic-based rehabilitation services after discharge from quality living, inc. exclusion criteria: * receiving services on a scholarship basis from quality living, inc., omaha, ne * scheduled to receive a combination of telerehabilitation and clinic-based services after discharge from quality living, inc.

Keywords: therapy health-related quality of life
feasibility of lymph edema-induced reticulation subtraction based on computerized tomography

Conditions: Lymphedema; Secondary Lymphedema; CT

Summary: development of lympho-proliferation reticulation quantification using ct.

it is known that fibrosis of the subcutaneous soft tissue progresses over time in the lymph edema, and this change progresses to reticulation pattern. authors will develop a digital subtraction technique for the extraction of lympho-proliferative reticulation using the housfield unit of non-reticulation structure (bones, muscles, tendons, vessels, nerves) in the axial image of ct. based on the medical records, authors will develop an early diagnosing tool by checking the correlation of the values derived the new technique with circumference, multi-frequency bio-electric impedance analysis, iso sub-stage, and lymphascintigraphy, and qualify the cut-off values showing high sensitivity and specificity through the receiver operating characteristics (roc) curve analyses.

Eligibility criteria:
inclusion criteria: * in- and out-patients who was diagnosed a secondary lymphoma and undertook ct on their limbs exclusion criteria: * primary lymph edema (congenital lymph edema, lymph edema precox, lymph edema tarda) * lymph edema simultaneously involving both limbs * patients who undertook implantation of electrical devices such as cardic pacemakers
long-term outcomes of alternative brachytherapy techniques for early prostate cancer

Conditions: Prostate Cancer

Summary: the purpose of this research study is to assess outcomes of treatment for early prostate cancer. current treatments for early (non-metastatic) cancer may cause long-term impairments in the patients quality of life. in this study we will compare the outcomes of patients treated with two alternative brachytherapy (seed implants) techniques using a series of questionnaires.

participants will be asked to complete a questionnaire about their health prior to treatment, at 1, 3 and 12 months after treatment and then once a year 4 more times.

Eligibility criteria:
inclusion criteria: * pathological diagnosis of an adenocarcinoma of the prostate * 18 years of age or older * prior choice of either standard brachytherapy or mrigpb as primary treatment exclusion criteria: * prior primary therapy (surgery or external beam radiation) for prostate cancer * current hormone ablation therapy

Keywords: brachytherapy radioactive seed implants
impact of ketogenic diets on cardiovascular health in adults with epilepsy

Conditions: Hypercholesterolemia; Carotid Intimal Medial Thickness 1; Seizure; Epilepsy; Cardiovascular Disease; Cerebrovascular Disease; Heart Disease; Coronary Disease

Summary: this research is being done to evaluate the short term and long term effects of ketogenic diets on measures of cardiovascular health. such measures include cholesterol levels, blood pressure, weight, and thickening of the blood vessel wall over time. adults aged 18 or older who are already on a ketogenic diet for at least 12 months or who are interested in beginning on the modified atkins diet may join.

if participants agree to be in this study, the investigators will ask the participants to do the following things: at initial enrollment for both longterm ketogenic diet and new modified atkins diet participants * review of calendars (showing seizures) and 3-day food record * check height and weight, blood pressure, skin-fold thickness and waist circumference * standard modified atkins diet clinic labs will be drawn as well as levels of low density lipoprotein (ldl) fractions, fatty acids, and apolipoproteins b and a-1 * participant will receive a high-resolution ultrasound of the carotid arteries in the neck performed either the day of enrollment or within 1 month of enrollment at follow-up clinic visits (month 3 and month 6) for new modified atkins diet participants * review of calendars and food records * labs repeated - standard modified atkins diet clinic labs as well as levels of low density lipoprotein (ldl) fractions, fatty acids, and apolipoproteins b and a-1 * check height and weight, blood pressure, skin-fold thickness and waist circumference at follow-up clinic visits (month 12 and month 24) for new modified atkins diet participants * review of calendars and food records * labs repeated - standard modified atkins diet clinic labs as well as levels of low density lipoprotein (ldl) fractions, fatty acids, and apolipoproteins b and a-1 * check height and weight, blood pressure, skin-fold thickness and waist circumference * participants will receive a high-resolution ultrasound of the carotid arteries in the neck performed either the day of follow-up or within 1 month of follow-up

Eligibility criteria:
inclusion criteria: * 18 years of age or older * body mass index (bmi) \> 18.5 * stable antiepileptic drug regimen for \> 1 month. exclusion criteria: * \< 18 years of age * body mass index (bmi) \< 18.5 * changes in antiepileptic drug regimen \< 1 month prior to participation * previous cardiovascular event or treatment ((including myocardial infarction, stroke, coronary artery bypass graft (cabg), percutaneous coronary intervention (pci)) * acute pancreatitis * unwilling to restrict carbohydrates * kidney disease * contraindicated metabolic or mitochondrial disorder

Keywords: cholesterol seizure epilepsy ketogenic diet
effect of trunk support on academic engagement of children with severe disability

Conditions: Cerebral Palsy; Traumatic Brain Injury; Metabolic Disease; Hypotonia

Summary: this study evaluates the effect of optimizing trunk support based on segmental principles of trunk control, on academic engagement of children in academic settings.

head and trunk posture control are foundational skills, impacting vision, communication, swallowing, eating, reaching, and gait. vision, communication and upper extremity skills are critical for participation in educational settings. from an academic point of view, participants with poor trunk stability have difficulties staying erect and keeping their head and trunk steady. this interferes with concentration, reduces ability and aptitude for learning and can lead to fatigue and reduced time on task. examination of the effect of optimal trunk support may yield critical information regarding academic engagement in children with moderate to severe disability. the investigators propose to facilitate use of a segmental approach by physical and occupational therapists in educational settings. activities will include identifying level of trunk control and applying segmental principles to adapt participant's positioning devices for optimal function.

Eligibility criteria:
inclusion criteria: * referral from physical, occupational or speech therapist working in hartford public school district or connecticut birth to three, * segmental deficit in trunk control as measured by segmental assessment of trunk control * parent or guardian consent that includes permission for video data collection and sharing of iep (individualized education plan) or ifsp (individualized family support plan). exclusion criteria: * pain that interferes with positioning, * impending surgery that will result in extended absence from school

Keywords: posture trunk control assistive device
tdcs and cognition in adults with multiple sclerosis or encephalitis

Conditions: Multiple Sclerosis; Encephalitis

Summary: this research is being done to determine whether transcranial direct current stimulation (tdcs) can improve certain mental abilities in individuals with multiple sclerosis (ms) or encephalitis. participants will be asked to come in daily for two full weeks during which time participants will undergo cognitive testing and magnetic resonance imaging (mri) brain scans. in this research, a very weak electrical current is administered to the surface of the scalp while participants complete cognitive tasks. the investigators' aim is to find out whether tdcs will improve task performance in adults with multiple sclerosis or encephalitis.

participants enrolled into this study may be asked to do the following: * come to the investigators' testing office at the johns hopkins hospital where the tdcs equipment is located for 10 study visits. * grant permission for the researchers to view medical records associated with the participant's diagnosis of multiple sclerosis or encephalitis (if applicable) and general state of health. * complete a questionnaire and provide a health history in order to verify eligibility to participate and be able to safely undergo the experimental procedures. * complete several computerized, written, and/or aural tasks (i.e., saying words out loud) that assess different cognitive functions such as attention, memory, language, or processing speed. * wear electrodes that will be placed on the scalp with a large rubberized band. these electrodes will administer very weak electrical current (tdcs) for 30 minutes. * participate in several study conditions. the exact conditions and the order will be randomized. that is, the conditions and order will vary by chance (like the flip of a coin). under some conditions, the participant might receive active stimulation (tdcs) and under other conditions, the participant might receive placebo (or sham) stimulation. placebo stimulation is similar to active tdcs but lasts only a few seconds. however, all groups will wear the electrodes for the same length of time to prevent the participant from knowing whether participants are receiving active tdcs or sham stimulation. the study doctor and research staff will know which group the participant is in. * permission to audio and/or video-tape test sessions for later scoring and observation. these tapes will not be viewed by anyone not affiliated with the study without the participant's consent. * have structural, resting-state and functional magnetic resonance imaging scans as a part of the study.

Eligibility criteria:
inclusion criteria: * diagnosis of multiple sclerosis or encephalitis * over the age of 18 exclusion criteria: * a diagnosis of schizophrenia bipolar disorder * beck depression inventory-ii scores over 20 * mini mental exam below 24 * any uncontrolled seizure disorder * any implanted metal device or hearing aids * use of medication shown to interact with tdcs effectiveness

Keywords: cognitive enhancement tdcs stimulation ms multiple sclerosis encephalitis
exercise training in asthma children

Conditions: Asthma

Summary: the purpose of this study is to assess the effects of a physical training program with active video game in inflammatory markers, quality of life variables , clinical control and physical and functional respiratory assessment of asthmatic children from 5 to 11 years.

the aim of the present study will be to determine whether an aerobic exercise using an active video game system improves asthma control, lung inflammation and functional capacity in children with moderate or severe asthma.

Eligibility criteria:
inclusion criteria: * ages 5 to 11 years; * having a diagnosis of asthma, according to the criteria of the national heart, lung, and blood institute, and * not be included in any program of regular physical activity. exclusion criteria: * having received aminophylline and theophylline or oral corticosteroids in the last 30 days; * respiratory infection have shown over the past two months; * have done with inhaled bronchodilator in less than 12 hours before the assessment; * inability to perform any of the tests; * have heart disease of inflammatory origin, congenital or ischemic; * being in the presence of any infectious process with fever and * do not agree to the terms of consent

Keywords: asthma childhood exercise
plant based diet, ethnicity, and the gut microbiome

Conditions: Diet Modification; Microbial Colonization

Summary: samples will be collected to determine human genetic variation, fecal and oral microbial communities, and metabolome products. several evolutionary and ecological diversity metrics will be distilled to test: a) if microbiome variation within each ethnicity is less than that between ethnicities; b) if microbiome variation is finely structured according to genetic relatedness; and c) if dietary variation impacts human genome x microbiome associations.

to characterize the human gut microbiome under highly controlled dietary intake in healthy normal weight adult participants who differ by ethnicity: white non-hispanic and black non-hispanic adults. samples will be collected to determine human genetic variation, fecal and oral microbial communities, and metabolome products. several evolutionary and ecological diversity metrics will be distilled to test: a) if microbiome variation within each ethnicity is less than that between ethnicities; b) if microbiome variation is finely structured according to genetic relatedness; and c) if dietary variation impacts human genome x microbiome associations.

Eligibility criteria:
inclusion criteria: * female * age 18-40 * bmi 18.5-24.9 * caucasian or african american exclusion criteria: * not weight stable * using medications * using dietary supplements * chronic disease * tobacco use * drug use * pregnant or lactating * diet restrictions * vegetarian or vegan