Kornimate/medical-research-clean huggingface dataset:
the effects of paco2 levels on cerebral metabolism and perfusion during induced hypothermia.

Conditions: Cerebral Metabolism and Perfusion

Summary: incidence of hypo- and hypercarbia during induced hypothermia after cardiac arrest is high. the original report from haca-group reported that hypothermia treated patients had improved survival and neurological outcome. suprisingly, in that trial normocarbia was not achieved even though the aim was set for ventilatory support as normoventilation. this study aims to investigate the effects of mild hypo- and hypercarbia on cerebral perfusion (blood flow, intracranial pressure) and metabolism (microdialysate metabolites). we hypothesize that uncontrolled ventilatory suppport may render the patients in risk of exacerbation of neuronal damage, conversely, further improvement in outcome may be achieved with succesfull ventilatory management. we intend to enroll 10 out-of-hospital cardiac arrest patients succesfully resuscitated and subsequently treated with controlled hypothermia for 24 hours. the patients in need of anticoagulation are excluded. we plan to induce mild hypocarbia and hypercarbia during and after induced hypothermia. metabolic and perfusion data are collected with clinically used methods such as transcranial doppler, intracranial pressure measurement, near infrared spectroscopy, jugular bulb, intracerebral microdialysis).


Eligibility criteria:
inclusion criteria: succesfull resuscitation of out of hospital cardiac arrest, primary rhytm shockable exclusion criteria: * known coagulopathy, need of anticoagulation therapy, need of interventional cardiological procedures

Keywords: cerebral metabolism, perfusion, induced hypothermia
the effect of acupressure applied before suturing procedure in the emergency department on anxiety and vital signs

Conditions: Anxiety; Vital Signs

Summary: this study suggests that the anxiety experienced by patients during suturing in the emergency department can be reduced with acupressure and offers a research proposal on vital signs. problem: during suturing in the emergency department, patients experience high levels of anxiety due to the pain they experience and fear of the procedure. this situation complicates the treatment process, negatively affects the health of patients and creates a difficult situation for healthcare professionals. solution suggestion: acupressure can be used as a non-invasive, safe and effective method to reduce patients\&#39; anxiety. acupressure reduces pain, provides relaxation and reduces anxiety by increasing the secretion of endorphins in the body. purpose of the study: the purpose of this study is to evaluate the effects of applying acupressure to patients before suturing in the emergency department on their anxiety levels and vital signs (such as blood pressure, heart rate). in summary, this research has a significant potential that emergency room nurses can improve patients\&#39; quality of life and make treatment processes more effective by using acupressure in patient care. key words: acupressure, suturing, anxiety, vital signs, emergency department


Eligibility criteria:
inclusion criteria: * suturing is done with local anesthesia, * those who are 18 years or older, * conscious, oriented and cooperative, * able to read and understand turkish, * agreeing to participate in the study, * anxiety not diagnosed, * not using medication for anxiety, * no acupressure experience, * no physical problems that would prevent acupressure application to ht7 and li4 points, * not pregnant, * patients who sign the \&#34;voluntary informed consent form\&#34; will be included. exclusion criteria: * those who are under 18 years of age, * unconscious, unoriented and uncooperative, * cannot read and understand turkish, * those who do not agree to participate in the study, * -diagnosed with anxiety, * -using medication for anxiety (anxiolytic, antidepressant, antipsychotic, etc.), * having previous acupressure experience, * having a physical problem that prevents the application of acupressure to ht7 and li4 points, * pregnant, * patients who do not sign the \&#34;voluntary informed consent form\&#34; will not be included.

Keywords: acupressure, suturing, anxiety, vital signs, emergency department
glucocorticosteroid therapy on drug-induced liver injury: a prospective non-randomized concurrent control trial

Conditions: Drug-induced Liver Injury

Summary: the purpose of this study is to assess the safety and efficacy of glucocorticosteroid for treatment of drug-induced liver injury.


Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of dili 2. rucam score≥6 and with liver histology 3. meet any of the following conditions: 1. tbil ≥ 10 fold uln ; 2. tbil ≥ 5 fold uln and serum ast or alt ≥ 20 fold uln exclusion criteria: 1. an chronic onset (≥6 months) 2. other liver diseases, such as autoimmune liver diseases, viral hepatitis, etc 3. with contraindications of glucocorticoid

Keywords: glucocorticosteroid
caffein consumption and response inhibition

Conditions: Eating Behavior; Obesity

Summary: with the abundance of energy-dense foods that are designed for ease of consumption in the current environment, it is of importance to better understand the factors that may undermine the control of energy intake at healthy levels. one of the factors that is potentially important in response inhibition is caffeine. the aim is to assess the direct effects of caffeine on response inhibition, using a no go/go-task. we will also assess whether the presentation of food cues, i.e. as words or as pictures, modulate response inhibition different in restrained vs. non-restrained eaters.

in a blinded, randomized cross-over design, participants will receive either a capsule with caffeine or placebo at two separate occasions whereupon study tasks will be performed.

Eligibility criteria:
inclusion criteria: * only males * 18 ≤ 35 years * healthy (self rated) * used to drink caffeine * used to eat breakfast regularly (≥ 5 times a week). * non-smokers exclusion criteria: * bmi outside the range of 18,5 ≤ 25 * hypersensitivity for the ingredients of the foods under study * being a vegan or vegetarian. participants reported not using products that are artificially sweetened, nor sugar in coffee and/or tea * presence of any chronically disease and/or treatment with medication

Keywords: caffeine effects inhibitory control
comparison of measures of plasticity

Conditions: Depression; Healthy

Summary: neuroplasticity refers to the ability of the nerve cells to modify their structure or function in response to injury or insult, or other environmental stimuli, with these changes outlasting the period of exposure. plasticity may be observed as short term or long term changes. in humans, neuroplasticity can be readily assessed in the motor cortex, as excitability changes are demonstrated in the degree to which peripheral muscles are activated, seen through changes in motor-evoked potentials (meps). in this study, a number of approaches to assessing neuroplasticity will be evaluated: paired-associative stimulation (pas), theta burst stimulation (tbs), which is a form of transcranial magnetic stimulation (tms) and protocols that combine these two. in addition, participants will complete a computerised 'rotor pursuit task' designed to provide a measure of motor learning. the investigators aim to find the most efficacious (defined by greatest number of responders and effect size as seen in an increase in mep amplitude) brain stimulation protocol. the investigators will expose the same participants to four excitatory conditioning stimulation paradigms, with each session separated by at least a week. our hypotheses include: the four conditioning stimulation protocols should increase motor cortical excitability, the investigators therefore expect there to be a significant increase in participant meps, with a positive correlation in the increase ofmep amplitude of the protocols. the investigators do however expect that due to the principles of homeostatic metaplasticity, that the protocols preceded by ctbs will show greater mep change, due to the lowering of the threshold for ltp plasticity induction. in addition, the investigators expect that an increase in the motor learning manifest by the rotor pursuit task and for there to be a correlation in participants between the increase in mep amplitude and the improvement in time on target (tot) shown in the motor learning task (mlt).


Eligibility criteria:
inclusion criteria: * healthy controls * those suffering depression * aged exclusion criteria: 1. significant neurological illness, including epilepsy 2. alcohol use above nhrmc guidelines 3. illicit drug use 4. electronic implant; such as cochlear implant or pacemaker 5. musculoskeletal disorder

Keywords: paired associative stimulation theta burst stimulation transcranial magnetic stimulation neuroplasticity healthy controls
epidemiology of in-hospital acute kidney injury

Conditions: Acute Kidney Injury; Dialysis; Complications; Chronic Kidney Diseases

Summary: retrospective observational study to investigate acute kidney injury (aki) epidemiology and outcomes in patients hospitalized in university hospital san martino, genova, italy.

a retrospective observational study was designed to investigate acute kidney injury (aki) epidemiology and outcome in patients hospitalized in university hospital san martino, genova, italy. all data will be extracted from the hospital electronic database. the investigators will evaluate demographic, clinical and laboratory data, including age, sex, serum creatinine (scr), sodium and electrolytes, intensive care unit (icu) admission, length of hospital stay, death, comorbidities and primary diagnosis codes at the hospital discharge (using international classification of diseases-icd-9- codes). the investigators will include also patients affected by coronavirus disease 19 (covid-19). the primary endpoint will be to describe aki epidemiology, secondary endpoints will be to evaluate aki-related risk factors and clinical outcomes, such as length of stay and mortality. moreover, the investigators will describe the differences in the outcome and treatments of aki patients in the medical wards and icu.

Eligibility criteria:
inclusion criteria: * patients admitted to university hospital san martino, italy * we'll include also patients affected by coronavirus disease 19 (covid-19). exclusion criteria: * hemodialysis patients
improving healthy living opportunities: laurel harvest

Conditions: Health Knowledge, Attitudes, Practice; Obesity

Summary: the goal of this pre-post intervention study is to understand how community-engaged approaches to policy, systems, and environmental approaches can work to improve fruit and vegetable consumption and food security status among an appalachian kentucky community. the main approaches taken will be to employ a community advisory board to define our target population of need, and appropriate intervention strategies. the investigators aim to understand if nutrition-based programming and food system approaches for lower-income, single-parent households, and multi-generational households can improve health. participants will engage in annual data collection to assess dietary quality and food security status.


Eligibility criteria:
inclusion criteria: * resident of laurel of pike county * over 18 years of age exclusion criteria: * pregnancy * non-english speaking * plans to move out of the counties within the next three years

Keywords: health equity food insecurity rural
prognostic and clinical impact of cardiovascular involvement in patients with covid-19

Conditions: Covid19; Myocardial Injury; Cardiovascular Diseases; Heart Failure; Cardiovascular Morbidity

Summary: covid-19 infection has been associated with numerous cardiac manifestations. indeed, sars-cov-2 may impact on cardiovascular system through a direct myocardial infection or a secondary cardiac involvement due to hypoxia or metabolic supply-demand imbalance or prothrombotic inflammatory state. as a consequence of and besides acute myocardial damages, covid-19 could also determine chronic cardiovascular consequences, with a significant impact on long-term prognosis, quality of life and functional capacity of covid-19 survivors. on this basis, we aim to define the clinical and prognostic effects of myocardial involvement in covid-19 patients.

covid-19 infection has been associated with numerous cardiac manifestations. indeed, sars-cov-2 may impact on cardiovascular system through a direct myocardial infection or a secondary cardiac involvement due to hypoxia or metabolic supply-demand imbalance or prothrombotic inflammatory state. as a consequence of and besides acute myocardial damages, covid-19 could also determine chronic cardiovascular consequences, with a significant impact on long-term prognosis, quality of life and functional capacity of covid-19 survivors. on this basis, we aim to define the clinical and prognostic effects of myocardial involvement in covid-19 patients, with a 1-month and 6-month follow-up composed of clinical evaluation, electrocardiogram, trans-thoracic echocardiogram, cardiovascular magnetic resonance, chest computerized tomography scan and cardiopulmonary exercise test.

Eligibility criteria:
inclusion criteria: patients who were hospitalized for covid-19 exclusion criteria: none.

Keywords: cardiovascular involvement covid-19
the use of platelet-rich plasma in the treatment of chronic anal fissure

Conditions: Fissure in Ano

Summary: use of platelet rich plasma had good effect in treating chronic wounds. healing of perianal fissure could be prolonged and associated with pain. injection of platelet rich plasma under fissure base and edges had the advantage of improved fissure healing and reduction of the pain, with minimal side effects.

thirty milliliters of venous blood were withdrawn into eight syringes with preloaded 0.4 milliliters of anticoagulant (dextrose solution a) in each syringe to achieve concentration of 9:1. the mixture centrifuged for 3000 round per minute for three minutes. after centrifugation separation of supernatant from the red blood cells, using three way-stopcock connector to collect the supernatant of all syringes into four new syringes that preloaded with 1 microgram of prostaglandin e1 that diluted in normal saline (0.05 milliliters). the four syringes centrifuge at 4000 round per minute for 15 minutes. the supernatant discarded using a three way-stopcock connector. the sediment mixed with vortex mixer (vortex v-1 plus, biosan).

Eligibility criteria:
inclusion criteria: • chronic anal fissure for more than three months exclusion criteria: * medical comorbidity * inflammatory bowel disease * tuberculosis fissure * hiv infected patients

Keywords: fissure in ano platelet-rich plasma lateral internal sphincterotomy
molecular mechanisms of tooth eruption

Conditions: Tooth Eruption

Summary: the main objective is to study the expression of molecules involved in tooth morphogenesis and eruption in healthy patients, and then to compare them with the results in patients with abnormalities of eruption (results obtained via a collection of biological samples of rare diseases already authorized).


Eligibility criteria:
inclusion criteria: * patient over 12 years old who has given his consent * patient whose legal representatives have given their consent for the use of operating waste destined for incineration * patient undergoing oral surgery at the university hospitals of strasbourg, at the origin of the production of surgical waste such as teeth and bone fragments * patient affiliated to a social security system exclusion criteria: * refusal to participate * patient with chronic systemic pathology * patient under long-term drug treatment * patient presenting a rare pathology with oral manifestation * patient with a history of chemotherapy or head and neck radiotherapy * non-french speaking patient / inability to give informed information * patient under guardianship, curatorship or legal protection
anxiety scores with media based patient education before dilatation and curettage

Conditions: Abnormal Uterine Bleeding; Anxiety

Summary: subjects with abnormal uterine bleeding and scheduled for dilatation and curettage (d\&c) will be randomized to a multimedia-based education (mme group) or verbal information (control group ) before (d\&c). state-trait anxiety inventory will be asked by the nursing staff before and after multimedia-based education or verbal information to all patients. then the patients will undergo (d\&c) at an office setting. the impact of mme on patient anxiety will be evaluated by statistical analysis.

subjects with abnormal uterine bleeding and scheduled for dilatation and curettage (d\&c) with diagnostic or treatment purpose will be randomized to two intervention arms. multimedia-education group (mme group) and verbal information group (control group). both groups will receive state-trait anxiety inventory before and after education and then will undergo d\&c at an office setting. state-trait anxiety inventory will be asked by the nursing staff. multimedia-based education will be carried out using a 5 minutes video explaining the details of d\&c. d\&c will be carried out at office setting by an experienced gynecologist under sedation and analgesia.

Eligibility criteria:
inclusion criteria: clinical diagnosis of abnormal uterine bleeding scheduled for dilatation and curettage must understand the characteristics of the study exclusion criteria: psychological disease contraindication for hysteroscopy visual deficit, auditory deficit

Keywords: dilatation and curettage multimedia based education anxiety
reboa for out-of-hospital cardiac arrest

Conditions: Cardiac Arrest

Summary: cardiac arrest is a major health problem that carries a high mortality rate. substantial research and development have been put into changing the outcome of cardiac arrest and despite the advent of automated external defibrillators (aed), increase in bystander cardiopulmonary resuscitation (cpr) and automated cpr devices (acpr), the proportion of patient survival to hospital discharge has only minimally improved. the objective is to investigate safety and performance of the resuscitative endovascular balloon occlusion of the aorta (reboa) procedure as an adjunct to advanced life support (als) for treatment of refractory cardiac arrest.

the scope of the study is to collect data on patients with refractory out of hospital cardiac arrest (ohca) for this feasibility study. data collected: * from enrolment of the patient until hospital arrival * every 24 hours * at discharge or 7 days post enrollment * at 30 days post enrollment the investigation is initiated to investigate the safety and performance of the reboa procedure for patients experiencing refractory ohca.

Eligibility criteria:
inclusion criteria: * witnessed cardiac arrest * bystander or professional cpr within 5 minutes * refractory cardiac arrest exclusion criteria: * end tidal co2 \<1,3 kpa * traumatic cardiac arrest * women with known pregnancy * patients with known terminal disease * patients with known do-not-attempt-cpr order * patients with overdose
a retrospective observational study to evaluate the utilization, outcomes, and adverse events in participants treated with orbactiv® (oritavancin) for infections caused by gram positive bacteria in a real world setting

Conditions: Gram-Positive Bacterial Infections

Summary: this study is a retrospective, observational study to evaluate oritavancin use in participants under real world conditions.


Eligibility criteria:
inclusion criteria: * the participant was treated with at least one dose of oritavancin for a suspected or confirmed gram positive infection, as monotherapy or part of a broader regimen. * at least 60 days has elapsed since the participant received the last dose of oritavancin therapy (prior to data entry into the electronic case report form). exclusion criteria: * the participant received oritavancin as a part of a controlled clinical trial. * the participant received oritavancin as a part of a medicines company-sponsored single or multi-centered pharmacoeconomic outcomes study.
micro-dosing indocyanine green (icg) in children

Conditions: Perfusion; Fluorescence Imaging; Gastrointestinal Tract Disorders; Genitourinary Disease

Summary: the goal of this cohort study is to identify the lowest dose of indocyanine green (icg) that achieves satisfactory intra-operative fluorescence for the assessment of gastrointestinal or genitourinary tract perfusion in children.

indocyanine green (icg) fluorescence-guided surgery (fgs) can be used to assess gastrointestinal and genitourinary tract perfusion intra-operatively. in adults, the use of icg has been shown to improve surgical outcomes. icg is safely used intra-operatively in children, but there is a lack of evidence regarding the lowest clinically useful dose of icg. this is a single centre open-label dose escalation study that aims to: 1. identify the minimal clinically useful dose of icg for intra-operative perfusion assessment in children (0 - 18 years old) 2. assess the safety profile of intra-operative icg in children 3. characterise the intra-operative fluorescence of icg in children

Eligibility criteria:
inclusion criteria: * children aged ≤18 years of age * elective surgery including gastrointestinal or genitourinary tract perfusion assessment exclusion criteria: * renal and liver dysfunction * active infection * coagulopathy * complex congenital heart defect * previous documented allergy to icg injection or other iodinated contrast agents * patients suffering from hyperthyroidism or autonomic thyroid adenomas * premature infants or neonates in whom exchange transfusion is indicated, due to the hyperbilirubinaemia risk * concurrent use of sodium bisulphite-containing preparations, such as certain heparin preparations

Keywords: paediatric surgery pediatric surgery fluorescence imaging fluorescence guided surgery (fgs) intra-operative perfusion assessment indocyanine green