Kornimate/medical-research-clean huggingface dataset:
swallowable sponge cell sampling device and next generation sequencing in detecting esophageal cancer in patients with low or high grade dysplasia, barrett esophagus, or gastroesophageal reflux disease

Conditions: Barrett Esophagus; Dysplasia; Esophageal Adenocarcinoma; Esophageal Squamous Cell Carcinoma; Gastroesophageal Reflux Disease; Metaplasia

Summary: this pilot clinical trial studies how well a swallowable sponge cell sampling device and next generation sequencing work in detecting esophageal cancer in patients with low or high grade dysplasia, barrett esophagus, or gastroesophageal reflux disease. checking biomarkers in abnormal esophageal cells using a swallowable sponge cell sampling device and next generation sequencing may improve diagnosis and treatment of esophageal cancer.

primary objectives: i. determine the sensitivity and specificity of next generation sequencing for the detection of esophageal cancer from esophageal sponge cytology specimens. secondary objectives: i. determine the ability of next generation gene sequencing (ngs) of esophageal sponge samples to collect an adequate sample to detect mutations that are present in the underlying tissue. ii. determine the cost associated with esophageal cytology with next generation genome sequencing as a screening tool. iii. continue to collect safety and tolerability data related to the use of the oesotest esophageal sponge. iv. determine the limitations of esophageal sponge cytology and future needs to improve this technique. v. use the data collected to design a larger screening trial to determine the ability of esophageal cytology with next generation sequencing to screen for esophageal cancer in the general population. outline: patients undergo cytology specimen collection procedure using a swallowable sponge cell sampling device.

Eligibility criteria:
inclusion criteria: * ability to understand and the willingness to sign a written informed consent document * patients must be scheduled for a procedure capable of providing a definitive pathologic diagnosis and evaluating for complications of the esophageal sponge on the same day as the study procedure, either upper endoscopy or surgical esophagectomy * one of the following inclusion criteria must be true for patient to be eligible for enrollment: * subjects with known esophageal cancer (adenocarcinoma or squamous cell carcinoma) * subjects with a history of low or high grade dysplasia * subjects with risk factors for esophageal malignancy including barrett?s esophagus and gastroesophageal reflux disease (gerd) exclusion criteria: * subjects that are unable to swallow a tablet/pill * subjects with completely obstructing esophageal cancer * subjects with known or suspected esophageal varices * uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * any condition which, in the opinion of the investigator precludes the patient from completion of the study procedure
assessing pain in the postoperative period by automatically measuring the variation coefficient of pupillary diameter: prevans study

Conditions: Anesthesia, General

Summary: different pain assessment methods have been proposed to evaluate analgesic efficacy after surgical operation. pain is a subjective phenomenon. patient did his pain self assessment. but, cooperation of the patient is limited by cultural differences, language barriers or residual effect of products used while general anesthesia. a lot of study were conducted to demonstrate and to quantify the pain after an operation. the aim will be dose analgesic treatment better without cooperation of the patient. this sudy concerns patients on the post anesthesia care units one hour after their arrival. they will have electrocardiogram and video-pupillometer.

primary objective is to compare variation coefficient of pupillary diameter (vcpd) obtained during a light flash and pain assessment realized thanks to visual analog scale (vas). too, variation coefficient of pupillary diameter (vcpd) with electrocardiogram will be measured to demonstrate a correlation between the three parameters.

Eligibility criteria:
inclusion criteria: * major patients * patients fluent in french * patient admitted on the post anesthesia care units exclusion criteria: * patients operated for all types of surgery except for heart, intra-cerebral, and ophthalmologic surgeries * emergency operation * heart rhythm disorders * pacemaker

Keywords: pain assessment pupillary diameter variation coefficient of pupillary diameter pain self assessment video-pupillometer electrocardiogram analgesic treatment
biomarkers in tissue samples from older women with breast cancer

Conditions: Breast Cancer

Summary: this research trial studies phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) mutation analysis in tissue samples from older patients with stage i breast cancer. studying samples of tissue from patients with stage i breast cancer in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (dna) and identify biomarkers related to cancer.

primary objectives: to assess the relapse free-survival difference between patients with pik3ca mutated and wild-type (wt) tumors and therefore validate pik3ca mutation status as an important biomarker in women 70 years or older diagnosed with breast cancer. outline: previously collected tissue samples are analyzed via mutation analysis of pik3ca.

Eligibility criteria:
* participants with stage i breast cancer (t1n0m0) and estrogen-receptor status positive or unknown * patients underwent lumpectomy with negative margins and were clinically node-negative

Keywords: stage ia breast cancer stage ib breast cancer estrogen receptor-positive breast cancer
neuroinflammation and postoperative delirium in cardiac surgery

Conditions: Delirium; Cardiac Surgery

Summary: up to 50% of patients over 60 years old develop postoperative delirium following cardiac surgery. delirium increases morbidity and mortality, and may lead to long-term cognitive impairment similar to patients with a diagnosis of alzheimer's disease. the underlying mechanisms behind delirium are not understood, and therefore the current prevention and treatment strategies are inadequate. several hypotheses exist for the pathophysiology of delirium, one of which is the role of neuroinflammation. the stress associated with high-risk procedures such as cardiac surgery may lead to systemic inflammation causing endothelial dysfunction and disruption of the blood brain barrier (bbb). when this occurs, the brain is susceptible to neuronal injury via neuroinflammation after which a state of delirium may ensue. to characterize the mechanisms of neuroinflammation in delirium, the investigators will explore the biomarkers most closely linked to each step of the proposed pathway.

aim 1a. test the hypothesis that endothelial injury is associated with delirium. the investigators hypothesize that endothelial dysfunction is associated with an increased incidence of delirium after cardiac surgery. to test this hypothesis, the investigators will measure biomarkers from subjects undergoing cardiac surgery. blood samples from three time points \[baseline, upon arrival to the intensive care unit (icu), and postoperative day 1 (pod1)\] will be analyzed and compared between patients that did and did not develop postoperative delirium. aim 1b. test the hypothesis that bbb disruption is associated with delirium. the investigators hypothesize that disruption in the bbb is associated with an increased incidence of delirium after cardiac surgery. to test this hypothesis, the investigators will measure levels of biomarkers at baseline, upon arrival to the icu, and on pod1. aim 1c. test the hypothesis that neuronal injury is associated with delirium. the investigators hypothesize that neuronal injury is associated with an increased incidence of delirium after cardiac surgery. to test this hypothesis, the investigators will measure levels of biomarkers at baseline, upon arrival to the icu, and on pod1.

Eligibility criteria:
inclusion criteria: * open heart surgery exclusion criteria: * acute coronary syndrome with troponin leak or unrelenting angina * liver dysfunction (transaminases 2x normal) * history of myopathy or liver dysfunction on prior statin therapy * use of potent cyp3a4 inhibitors such as antifungal azoles, macrolide antibiotics, hiv protease inhibitors, and nefazodone. * pregnancy or breast feeding * cyclosporine use * dialysis * history of kidney transplant * fibrate users who cannot stop fibrate use
pac-ic-saos obstructive sleep apnea syndrome and ventricular function

Conditions: Heart Failure; Arteriosclerosis of Coronary Artery Bypass Graft or Other Coronary Reperfusion; Sleep Apnea, Obstructive

Summary: the aim of this clinical trial is to evaluate the effect of obstructive sleep apnea syndrome (osas) treatment in heart failure patients following coronary artery bypass graft (cabg) surgery or other coronary reperfusion.

this clinical trial is a double-blind, randomized, placebo-controlled study. the first objective is to evaluate the influence of continuous positive airway pressure (cpap) treatment for osas on the ventricular function improvement in heart failure patients, in comparison with osa patients treated with sham cpap. this treatment will be instaurated just after the coronary reperfusion surgery secondary objectives : * evaluation of the effect of cpap treatment on the endothelial function * evaluation of the effect of cpap treatment on systemic inflammation * evaluation of the effect of cpap treatment on oxidative stress, * evaluation of the effect of cpap treatment on insulin resistance, after the coronary reperfusion surgery, in comparison with osa patients treated with sham cpap and non apneic control patients, with heart failure. * assessment of the impact of nocturnal desaturation level on the vascular reactivity and atherosclerosis of mammary vessels collected during surgery. * assessment of the impact of nocturnal desaturation level on the oxidative stress, inflammation and insulin sensitivity on abdominal and epicardiac adipose tissue collected during surgery.

Eligibility criteria:
inclusion criteria: * coronary artery bypass surgery or other coronary reperfusion * heart failure patient: with altered left ventricular ejection fraction by ultrasonography (≤ 50% in 2d) or in 3d exclusion criteria: * aortic or mitral valvular replacement * aortic surgery * triple stimulator implanted less than 6 months ago * patient already treated for a saos syndrome * patient with a central sleep apnea syndrome * patient with malignant evolutive pathology * pregnant or lactating women

Keywords: obstructive sleep apneas syndrome continuous positive airway pressure treatment heart failure coronary reperfusion surgery
chest trauma :prediction of thoracic injuries clinically and radiologically

Conditions: Chest Trauma; Fluid Balance; Disorder

Summary: • trauma is a major cause of morbidity and mortality worldwide. despite the advent of specialized trauma centers the outcome of patients who sustain major trauma remains disappointing. plain radiography and more advanced imaging techniques such as ultrasound, computerised tomography (ct) and angiography, have a major role to play in the early decision making and subsequent management of patients who sustain polytrauma. this article discusses the choice of emergency imaging techniques available in chest trauma for clinicians and radiologists; their evaluation and some of the common pitfalls that may lead to errors of interpretation.

imaging plays a key role for both, the primary diagnostic work-up, and the secondary assessment of potential treatment. despite its well-known limitations, the posteroanterior chest radiograph remains the starting point of the imaging work-up. adjunctive imaging with computed tomography, that recently is increasingly often performed on multidetector computed tomography units, adds essential information not readily available on the conventional radiograph. this allows better definition of trauma-associated thoracic injuries not only in acute traumatic aortic injury, but also in pulmonary, tracheobronchial, cardiac, diaphragmal, and thoracic skeletal injuries. this article reviews common radiographic findings in patients after chest trauma, shows typical imaging features resulting from thoracic injury, presents imaging algorithms, and recalls to the reader less common but clinically relevant entities encountered in patients after thoracic trauma.

Eligibility criteria:
inclusion criteria: * chest trauma 2. recent trauma: presented within48 h exclusion criteria: * old trauma more than 48h 2-pt transferred urgently to operating room
effect of moisturizer on malaysian women facial skin

Conditions: Healthy

Summary: the goal of this clinical trial is to evaluate the effect of product x on facial skin of middle-aged women in malaysia. the main questions it aims to answer are: 1. the effect of product x on skin hydration of middle-aged women in malaysia. 2. the effect of product x on skin elasticity of middle-aged women in malaysia. 3. the effect of product x on skin wrinkle of middle-aged women in malaysia. 4. to observe any adverse effect occurrence with the use of product x. participants will used product x for 8 week and the skin assessment will be carried out at baseline, week 2, 4 and week 8.


Eligibility criteria:
inclusion criteria: * malaysian citizen * middle-aged woman (40-60 years old) exclusion criteria: * participants taking isotretinoin * immunocompromised patients or participants with any skin diseases or diseases that may compromised the participants well-being and study outcome. * participant who undergo any cosmetic procedures such as laser \& light treatment for the past three months. * participant with a history of facial surgery.

Keywords: middle-aged women, moisturizer
transcutaneous bilirubin levels from covered skin

Conditions: Hyperbilirubinemia, Neonatal

Summary: the aim of this study was to evaluate the levels of total serum bilirubin and transcutaneous bilirubin in newborns, measured in both covered and exposed areas, before phototherapy, 24th hour of phototherapy and 8 hours after cessation of phototherapy. the study included term and preterm newborns that required phototherapy between postnatal days 0-28. total serum bilirubin levels and transcutaneous bilirubin measurements were obtained using the mbj20-2019 transcutaneous handheld bilirubinometer (beijing m\&b electronic instruments co. ltd. china, 2019) from both exposed (sternal) and unexposed (forehead, covered with a radio-opaque patch) areas before, at 24th hours and eight hours after phototherapy.

aim: this study aimed to evaluate total serum bilirubin and transcutaneous bilirubin levels measured from covered and exposed areas in newborns before phototherapy, after 24 hours of phototherapy, and 8 hours after discontinuing phototherapy. materials and methods: term and preterm newborns who needed phototherapy between postnatal days 0-28 were included in the study. total serum bilirubin values and transcutaneous bilirubin measurements by mbj20-2019 transcutaneous handheld bilirubinometer (beijing m\&b electronic instruments co. ltd. china, 2019) from the exposed area (on sternum) and an unexposed area (forehead, covered with a radioopaque patch) were obtained before starting phototherapy, after 24 hours of phototherapy, and at 8 hours after phototherapy. the results were analyzed statistically using intraclass correlation coefficients (icc).

Eligibility criteria:
inclusion criteria: aged 0-28 days, diagnosis of indirect hyperbilirubinemia parent/guardian consent was obtained. exclusion criteria: direct hyperbilirubinemia, major congenital anomaly, severe sepsis, circulatory disorder, need for blood exchange, rehospitalization
a trial to study neladenoson bialanate over 20 weeks in patients with chronic heart failure with preserved ejection fraction

Conditions: Heart Failure

Summary: the objective of the study is to find the optimal dose of once daily oral neladenoson bialanate (bay1067197) when given in addition to appropriate therapy for specific comorbidities.


Eligibility criteria:
inclusion criteria: * men or women aged 45 years and older * diagnosis of chronic heart failure, nyha (new york heart association) class ii-iv, lvef (left ventricular ejection fraction) ≥ 45% and elevated nt-probnp exclusion criteria: * acute decompensated heart failure within the past 4 weeks * inability to exercise * previous diagnosis of hfref (heart failure with reduced ejection fraction) (lvef \< 40%)

Keywords: chronic heart failure heart failure with preserved ejection fraction
neuroimaging of diet in adhd: phase i

Conditions: Attention Deficit Disorder With Hyperactivity

Summary: children with attention deficit hyperactivity disorder (adhd) aged 9-12 years of age will be placed on a restriction diet for a 5 week period. children will be randomized to either receive daily snacks that conform to the diet or will violate the diet (ruse diet) in a double blind fashion. it is hypothesized that children who are consistently on the restricted diet (relative to those on the ruse diet) will show improvements in adhd symptoms.

the adhd rating scale (rs) will be the principal behavioral outcome measure. we hypothesize that children on restriction diet will have significantly lower adhd rs scores after 5 weeks relative to the ruse diet group. in addition children will undergo functional magnetic resonance imaging (fmri) at baseline and again at 5 weeks. children will perform a flanker task known to engage the dorsolateral prefrontal cortex (dlpfc) and the anterior cingulate cortex (acc) during attention tasks. the children will also perform will look at pictures of appealing and unappealing food and rate whether they would like to eat it or not. this task is known to activate the ventral striatum (vs) (reward processing). a secondary hypothesis is whether children on the restricted diet will show changes in activity and connectivity of areas (dlpfc, acc, vs) relative to those on the ruse diet.

Eligibility criteria:
inclusion criteria: * age 9-12 years * meets criteria for attention deficit hyperactivity disorder * parent must agree to use study diet manual exclusion criteria: * any axis i psychiatric disorder other than oppositional defiant disorder or anxiety disorder not requiring psychopharmacological management * not currently on any pharmacological agent other than medication for adhd

Keywords: adhd diet functional magnetic resonance imaging
the role of biodentine in class v dental lesions on oral health related quality of life

Conditions: Quality of Life; Cervical Abrasion

Summary: the study will compare two different dental materials on dental lesions near the gum line that cause chronic pain on oral health related quality of life.

the study will compare two different dental materials on dental lesions near the gum line. one of the materials is tooth colored and the other material is white but both materials use different mechanisms to attach to the teeth and may have different outcomes. the study will determine if one material is more effective in relieving chronic pain. in addition, we will evaluate changes in oral health related quality of life after the placement of the two different dental materials.

Eligibility criteria:
inclusion criteria: * males and females age 18-64 * chief complaint associated with pain from cold or hot * chronic sensitivity associated with supragingival lesions * pain not associated with decay * fluent in english and able to read english at a 6th grade level * pulpal response \<40 via pulp tester * active salivary flow from palpation of parotid and submandibular glands * patients self reporting pain over 6/10 in the past week and/or the past 2 months exclusion criteria: * pregnant women * patients taking benzodiazepines, narcotics and multiple antidepressants for pain management not associated with the oral cavity * unexplained dry mouth * patients taking two or more medications associated with dry mouth * pulpal response \>40 via pulp tester * patients requiring treatment for more than 5 decayed sites, periodontal disease and root canal therapy * complicated medical history (\>4 concurrent treatment for systemic diseases) * lesion \>1mm below the gum line
biomagnetic characterization of gastric dysrhythmias:study 2

Conditions: Ischemia

Summary: the purpose of this study is to use the squid magnetometer (superconducting quantum interference device) to help diagnose electrical and mechanical abnormalities of the stomach and intestines.

the squid magnetometer is a non-invasive investigational device that measures the electrical activity in the smooth muscle of the intestines. volunteers with normal bowel activity, those with gastric problems, and diabetics with gastric problems will be studied under the squid to determine normal and abnormal activity. diabetics with an abnormal gastric emptying study will be asked to participate.

Eligibility criteria:
inclusion criteria: * normal volunteers, those with stomach problems, and diabetics with abnormal gastric emptying study exclusion criteria: * diabetics with a normal gastric emptying study * participants with claustrophobia

Keywords: blood supply mesentery
patient education to improve pain management in older adults with acute musculoskeletal pain: a pilot randomized trial

Conditions: Musculoskeletal Pain

Summary: this is a three arm pilot randomized trial. patients will be assigned to: 1. usual care 2. video education in the emergency department (ed) 3. video education in the ed plus phone follow-up at three days with geriatric pain management specialist for all patients with pain \>=4/10

this is a three arm pilot randomized trial. patients will be assigned to: 1. usual care 2. video education in the ed (10 minute interactive video) 3. video education in the ed plus phone follow-up at three days with geriatric pain management specialist for all patients with pain \>=4/10

Eligibility criteria:
inclusion criteria: * age 50 and older; ed visit for acute musculoskeletal pain exclusion criteria: * cognitively impaired; chronic pain (daily opioid use prior to onset of pain or pain symptoms more than one month); prison; injury or pain condition requiring hospital admission.
antisocial behavior on healthcare professionals in an emergency unit.

Conditions: Rudeness/Incivility, Aggression or Violence Against Healthcare Workers in an Ophthalmic Emergencies Unit.

Summary: at the hospital, the attacks against health professionals are becoming commonplace, making working conditions difficult. the ophthalmological emergencies are a perfect testing ground to evaluate the effectiveness of a series of original actions to prevent the occurrence of violence against healthcare workers. the main objective is to measure the impact of an integrated prevention of the occurrence of antisocial behavior or attacks against the healthcare workers. the prevention program combines five interventions (steps): 1) a computer sorting algorithm and specific screens for calling patients in waiting rooms, 2) a clear signage to direct patients between waiting rooms, treatment rooms and administrative et medical offices, 3) posts information on the activity of emergency services displayed on screens, in the waiting rooms, 4) a mediator/go-between/conciliator, 5) and a dummy surveillance camera. this is an interrupted time series study. all patients admitted to the ophthalmological emergency unit of a university hospital located in lyon, france, are included in the study, from june 2013 to sept 2015


Eligibility criteria:
inclusion criteria: * patient admitted to the ophthalmologic emergency unit no exclusion criteria

Keywords: incivility rudeness aggression violent act healthcare workers emergency unit