Kornimate/medical-research-clean huggingface dataset:
arts and movement therapies for trauma

Conditions: PTSD; Depression; Anxiety; Stress; Trauma

Summary: the current goal of this project is to subjectively and objectively assess the efficacy of arts and movement interventions--including dance/movement therapy, art therapy and mindful yoga for youth and adults exposed to trauma, including families resettled as refugees and families in high-risk, low-resource environments. the overarching aim is to measure the changes over time in self-reported symptoms of posttraumatic stress disorder, anxiety disorder(s), depression, and somatic symptoms, as well as changes in biological substrates representing pathophysiological processes involved in responses to stress, trauma, and the aforementioned disorders. these biological substrates include inflammatory proteins and the stress hormone cortisol. we hypothesize that given the emotional and physical components of arts and movement therapies, which are implemented in group settings and confer life-long coping skills to participants, participation in arts and movement therapies will result in reduction of self-reported severity of psyciatric symptoms and improved physiology. covid-19: in march, the covid-19 pandemic caused in person research to be halted in order to be in adherence to the stay at home order for the state of michigan. the irb overseeing the present project approved an amendment to allow data to be collected online via phone or email, based on participant preference, with a new consent form for this new method of data collection. following this approval, we migrated our programming to virtual formats and began to serve both refugee commuities as well as school-aged youth with the intervention program and obtained consent followed by data from participants as part of this study. we have pivoted towards also looking at the benefits of creative arts and movement based interventions in reducing covid-related distress, as well as building resilience. by collecting psychological and biomarker data the investigators seek concrete scientific evidence supporting these non-pharmacological, cost effective, and accessible programs as reliable treatment options.


Eligibility criteria:
inclusion criteria: * male and female children and adults ages 7-65 * willing and able to consent, or with at least one parent willing and able to provide consent for minors under age 18 exclusion criteria: * adults who are unable or unwilling to consent, or children whose parent do not consent * wardens of the court
feasibility of high dose proton therapy on unresectable primary carcinoma of liver: prospective phase ii trial

Conditions: Liver Neoplasm; Proton Therapy

Summary: the standard treatment of unresectable hepatocellular carcinoma (hcc) is transarterial chemoembolization (tace) or sorafenib. though the tace and the agent showed survival benefit in several randomized phase iii trials, the benefit was modest. recently, radiotherapy (rt), especially conformal and higher dose with the advancement of rt techniques, showed favorable response rate with acceptable local control rate. based on those promising results, rt was actively applied in hcc who are not indicated with surgery and/or radiofrequency ablation. many researchers reported that there is a relationship between rt dose and tumor response rate. rt dose, however, is frequently limited because the complications (like radiation induced liver disease (rild), radiation induced gastro-duodenal toxicity, etc.) are also closely related with higher exposed rt dose. proton beam has characteristic depth-dose distribution contrast to photon, the "bragg peak". the advantage of this dose distribution could be more highlighted in hcc management, because of the weakness and maintenance importance of liver function itself in hcc patients. in fact, the superior results of proton beam therapy in hcc were constantly reported in several groups as prospectively as well as retrospectively. in this background, the investigators planned the present study to evaluate the efficacy and safety of proton beam therapy in hcc patients who are not indicated with surgery and/or radiofrequency ablation (rfa).


Eligibility criteria:
inclusion criteria: * hepatocellular carcinoma (hcc) patients (pathologically proven or hcc diagnosed based on american association for the study of liver diseases (aasld) guideline) * not indicated with surgical resection and/or rfa * discussion in tumor board including gastroenterologist, radiologist, radiation oncologist * eastern cooperative oncology group performance status 0 to 2 within 1 week before participate * adequate bone marrow function (absolute neutrophil count ≥ 1.0 x 109/l, platelet ≥ 30 x 109/l, hemoglobin ≥ 8 g/dl) * adequate liver/renal function within 1 week before participate * total bilirubin \ 50 ml/min * informed consent * if viable tumor is single, 1 cm to 10 cm * less than 3 nodules * child-pugh class a, b, or early c (score ≤ 10) * women of childbearing potential and male participants must agree to practice adequate contraception while on study and for at least 6 months following the last dose of rt exclusion criteria: * uncontrolled hepatic encephalopathy * previous history of upper abdominal radiotherapy * status of pregnancy or breast feeding * less than 12 weeks of expected survival * uncontrolled ascites * combined with disease known as radiosensitive disorder (connective tissue disorder, ataxia-telangiectasia) * hard to maintain stable respiration less than 5 minutes related with respiratory disease * combined with uncontrolled severe acute disease other than liver
role of fdg pet/ct in patients with metastasis of unknown origin

Conditions: Metastasis

Summary: evaluatation of the role of f18fdg-pet/ct in patients with metastases of unknown origin.

cancer of unknown primary origin (cup) includes a cluster of heterogeneous tumors that have exceptional clinical features: it is defined as early apparent metastatic disease with no recognizable primary site at the time of presentation. the incidence of cup ranges around 2% of all new cancer diagnoses. the work up list of cup include; a biopsy proven malignancy, a detailed physical examination, many laboratory, radiological and endoscopy. however, these investigations may be costly time-consuming and may eventually fail to detect the site of the primary malignant tumor in the majority of patients. in this context, positron-emission tomography (pet) combined with computed tomography (pet/ct), using the radiotracer 18f fluoro- 2-deoxyglucose (fdg) is an alternative, non-invasive imaging modality with accurate diagnostic performance. it considered good tool for diagnosis of patients with cup . the basis for use of fdg as radiotracer for pet imaging in cup depends on the fact that most of the malignant cancer phenotypes show an increased glucose metabolism rate. failure to identify the primary tumor hampers optimization of management planning, which in turn may adversely influence patient prognosis.

Eligibility criteria:
inclusion criteria: * patients with age more than 18 years presented with either pathologically proved metastases of unknown primary or * patients with clinico-radiological suspicious of having metastases. exclusion criteria: * • age below 18 years, * patients with pathologically proved primary tumor, * patients suffering from advanced disease and in-cooperative patients. * pregnant and lactating women. * patients who had motion artifacts, or those who can't stay stable or calm during acquisition.
trial comparing pegfilgrastim with filgrastim as an adjunct to chemotherapy for acute myeloid leukaemia (aml)

Conditions: Myeloid Leukemia

Summary: the purpose of this study is to determine if a single dose of pegfilgrastim is able to reduce the time of severe neutropenia in patients receiving induction and consolidation myelosuppressive chemotherapy for de novo acute myeloid leukemia similar to filgrastim.


Eligibility criteria:
inclusion * histologically confirmed de novo aml as evidenced by absence of an antecedent hematologic disease of \> 1 months duration, prior chemotherapy, prior radiation therapy or myelodysplastic cytogenetics (as per exclusion criteria) * life expectancy, with treatment, \> 3 months * age \> 18 years * ecog performance status 0, 1 or 2 * adequate organ function to receive protocol specified chemotherapy exclusion * subjects in blast transformation of chronic myeloid leukaemia (cml) * patients with secondary aml (received previous chemotherapy or radiotherapy) * previous treatment for aml * patients with aml fab type m3 (acute promyelocytic leukemia, apl) or m7 * high risk (unfavourable) cytogenetics \[(-5/del(5q), -7/del(7q), t(8;21) with del (9q) or complex karyotype, inv(3q), abn 11q23, 20q, 21q, del(9q), t(6;9), t(9;22), abn 17p, complex karyotypes(\>3 abnormalities)\]

Keywords: acute myeloid leukaemia pegfilgrastim neulasta® neutropenia induction chemotherapy consolidation
the big score and in-hospital trauma mortality

Conditions: Multiple Trauma; Injury Traumatic

Summary: this study investigated the efficacy and reliability of the big score, calculated based on the base deficit (bd), international normalized ratio (inr), and glasgow coma scale (gcs), in comparison with the gcs, revised trauma score (rts), and injury severity score (iss) for predicting in-hospital mortality in adults with multiple-trauma presenting to the emergency department (ed).

this retrospective, observational, single-center study included 563 consecutive adults (≥ 18 years old) with multiple trauma who were admitted to our emergency department and hospitalized between january 2022 and december 2023. we assessed patient demographics (age and sex), vital signs on admission (systolic blood pressure \[sbp, mmhg\], heart rate \[hr, beats/min\], respiratory rate \[rr, breaths/min\], and peripheral oxygen saturation \[spo2, %\]), complaints and symptoms on admission, anatomic region of injury, type of trauma (blunt or penetrating), mechanism of injury, bd measured in blood gases, inr, trauma scoring systems (e.g., gcs, rts, iss, and big score), and clinical outcomes (discharge, hospitalization, or death). the study cohort was divided into survivors and non-survivors. survivors were defined as patients who were still alive after 28 days, while non-survivors had passed away within that time. the demographics, clinical characteristics, and trauma scoring systems were compared between survivors and non-survivors to determine the prognosis of patients with multiple trauma. independent predictors of mortality were determined by multivariate logistic regression analysis of variables (demographic characteristics, clinical characteristics, and trauma scores) that differed significantly between survivors and non-survivors. receiver operating characteristic (roc) curve analysis was performed to establish cut-off values for the gcs, rts, iss, and big score, and then to assess the sensitivity and specificity of these scoring systems in terms of predicting in-hospital mortality.

Eligibility criteria:
inclusion criteria: * this study included 563 consecutive adults (≥ 18 years old) with multiple trauma who were admitted to our emergency department and hospitalized between january 2022 and december 2023. exclusion criteria: * patients aged \< 18 years and adults who were discharged from the emergency department * patients with non-traumatic injuries and those who presented to the emergency department for reasons other than trauma * patients with missing base deficit and international normalized ratio levels * patients who had been admitted to the hospital more than 24 hours after the trauma * patients with single trauma (e.g., isolated extremity trauma, isolated head injury, etc.) * patients with chronic conditions such as chronic renal failure or hepatic, hematological, or neurological diseases

Keywords: big score revised trauma score injury severity score mortality multiple trauma
effect and cost evaluation of a multifaceted approach with a patient-centredness questionnaire in fertility care

Conditions: Patient Centredness; Quality of Life; Risk Factors for Emotional Maladjustment

Summary: the purpose of this study is to evaluate the effects and costs of a multifaceted approach on the patient-centredness of fertility care and the quality of life of fertility patients.

besides traditional outcomes as (cost)-effectiveness and safety, the institute of medicine calls patient-centredness as an independent outcome indicator to evaluate quality of healthcare. nevertheless, within fertility care there is great variation in the delivery of patient-centred care and room for improvement. the effects of a multifaceted approach on patient centredness and quality of life will be determined by a baseline and after measurement. three questionnaires will be used to measure patient centredness (patient centredness questionnaire-infertility), quality of life (fertiqol) and risk factors of emotional maladjustment(screenivf). the multifaceted approach consists of: 1)audit and feedback, 2) educational outreach visits, and 3) patient-mediated interventions. during one year the multifaceted approach is performed followed by an after measurement with the same questionnaires. the effects and costs of the multifaceted approach will be determined. process evaluation will be performed to investigate feasibility and to study wether and to what extend patients and professionals used and appreciated the elements of the multifaceted approach.

Eligibility criteria:
inclusion criteria: * patients undergoing mar-treatment (ovulation induction, intra-uterine inseminations, in vitro fertilization, or intra-cytoplasmic sperm injection). exclusion criteria: * pregnant couples

Keywords: patient centredness quality of life multifaceted approach fertility care
efficacy vulvovaginitis candida

Conditions: Candidiasis Vulvaginitis

Summary: to compare the therapeutic efficacy of 10 mg, 40 mg, 80 mg, 160 mg and 320 mg of albaconazole, as a single oral dose, in women affected by acute non-complicated vulvovaginitis due to candida spp.

multi-center, open-label, randomized study, controlled with fluconazole.

Eligibility criteria:
inclusion criteria: * ambulatory patients over 18 years of age, with a vaginal score sum ³ 2 and koh fresh examination positive for yeasts (hyphae, pseudohyphae). the diagnosis must be later confirmed with a positive candida spp. culture. exclusion criteria: * patients with recurrent disease, prior treatment with antifungal agents within the last 7 days, immunosuppression, pregnant or lactating women, other vulvovaginal diseases, other systemic diseases, hypersensitivity to azole derivatives.number of patients: 78 patients included to obtain 60 evaluable patients

Keywords: antifungal oral therapy efficacy acute candidiasis vulvaginitis
artificial intelligence system for assessing image quality of fundus images and its effects on diagnosis

Conditions: Retinal Diseases; Artificial Intelligence

Summary: fundus images are widely used in ophthalmology for the detection of diabetic retinopathy, glaucoma and other diseases. in real-world practice, the quality of fundus images can be unacceptable, which can undermine diagnostic accuracy and efficiency. here, the researchers established and validated an artificial intelligence system to achieve automatic quality assessment of fundus images upon capture. this system can also provide guidance to photographers according to the reasons for low quality.


Eligibility criteria:
inclusion criteria: * patients should be aware of the contents and signed for the informed consent. exclusion criteria: * 1. patients who cannot cooperate with a photographer such as some paralytics, the patients with dementia and severe psychopaths. * 2. patients who do not agree to sign informed consent.
growth and development of children with congenital heart disease (chd)

Conditions: Researcher-Subject Relations

Summary: the effect of individualized nutrition training given to the families of children with congenital heart disease (chd) in the post-operative period on their growth and development this study was conducted experimentally to determine the effects of individualized nutrition training given to mothers of children who had surgery for chd on their growth and development.

the effect of individualized nutrition training given to the families of children with congenital heart disease (chd) in the post-operative period on their growth and development this study was conducted experimentally to determine the effects of individualized nutrition training given to mothers of children who had surgery for chd on their growth and development. the data of the study were collected at çukurova university medical faculty balcalı hospital cardiovascular surgery between 20/01/2021-30/06/2021. the research was conducted by interviewing the families of 42 children with congenital heart disease. personal information form, growth parameters and ankara developmental screening inventory were applied to three groups formed as two experimental and control groups by randomization method. family-centered care and individualized nutrition training were applied to the first experimental group who was fed orally and and the second experimental group orally and nutritionally fed. these trainings were about nutritional contents suitable for the age of the baby, the way of preparing the food and meeting the calorie needs of the baby. no training was given to the control group during the research process. the growth and development parameters of all three groups were evaluated and the effect of education was examined.

Eligibility criteria:
inclusion criteria: * congenital heart disease, * born on time (38-42 weeks) * over 2.300 gr. * fed with additional nutritional support to oral and oral nutrition, * decided to have surgery, * 0-3 years old, * the children and their families who were followed up in the post-operative service were included. exclusion criteria: * no congenital heart disease * not planned to have surgery, * over 3 years old, * children with additional congenital malformation, dysmorphic syndrome, chromosomal disease, severe infection, hypothyroidism and similar disorders that may cause growth and development retardation were excluded from the study.

Keywords: child health and nursing congenital heart disease family centered care growth and development i̇ndividual nutrition education.
closed loop stimulation for neuromediated syncope (spain study)

Conditions: Syncope, Vasovagal

Summary: physiological stimulation therapy effectiveness will be proved with contractility sensor or cls sensor (closed loop stimulation), in biotronik cls pacemakers to prevent from neuromediated syncope. furthermore, not only will be investigated if this system eradicates syncopes, but also if the number of presyncopal episodes is reduced.


Eligibility criteria:
inclusion criteria: * patients that fulfill the requirements of the study: * patients with 5 previous neuromediated syncopes * positive tilt test, cardioinhibitory response, heart rate \ 3'' * patient ≥ 40 years * no cardiopathy present * patients without the following contraindications: * drug treatment with β-blockers * chronic polyneuropathy * all contraindications for ddd or dddr pacing (as per clinical guidelines sec, 2002) * geographically stable patients and able to attend all follow ups * patients that have signed the informed consent exclusion criteria: * patients that do not fulfill the inclusion criteria mentioned above * patients with the contraindications indicated above * patients with syncopes due to carotid sinus hypersensitivity * other syncope causes different to the cns * patients involved in other clinical studies * pregnant women or in age bearing that are not using at least 2 contraception methods

Keywords: neuromediated syncope tilt test pacemaker cls sensor
study of the effects of atorvastatin on cholesterol levels in rheumatoid arthritis patients taking cp-690,550

Conditions: Rheumatoid Arthritis

Summary: all patients will be in instructed to eat a therapeutic lifestyle diet and will receive cp-690,550 throughout the 12 weeks of this study. after 6 weeks, half will receive the cholesterol lowering agent, atorvastatin, and half a matching placebo. this study will first measure the effects of cp-690,550 on cholesterol levels and then the effects of adding atorvastatin on those levels.


Eligibility criteria:
inclusion criteria: * must be diagnosed as having active rheumatoid arthritis * agree to participate in the study and sign and informed consent document exclusion criteria: * history of serious infection within the past 6 months * test positive for tb * have any uncontrolled clinically significant disease or laboratory tests * require administration of prohibited medications during the study

Keywords: cholesterol lipids rheumatoid arthritis cp-690 550
the effect of the use of computer game- "my diabetic friend" in children with type 1 diabetes

Conditions: Type 1 Diabetes

Summary: a randomized controlled study to evaluate the effect of 3 months use with interactive computer game- "my diabetic friend"- comparing to conventional diabetes education on metabolic control, quality of life and diabetes knowledge.patients will be randomized into two groups- one group will be supplied with interactive computer game, "my diabetic friend", installed on a computer designed for children's educational needs for a period of three months and the other group will be supplied with the same computer without the interactive computer game for three months. metabolic control, quality of life and diabetes knowledge will be evaluated before and after the use of the computer. the trial is consisting of two main periods: 3 months of the main study period and an optional extension period consisting of the following 3 months : the study will include two main periods; 1. period 1 which will last 3 months, in a randomized controlled manner, this period will serve as the main study period to assess the primary and secondary endpoints of the study. 2. period 2: this extension period will not be an integral part of the study, and only patients who are willing will take part at this period, will continue to participate at the optional extension period. during the extension period, patients in the intervention group will be offered to continue the use of the computer game -"my diabetic friend) for the following 3 months, and patients who participated at the control group during period 1, will be offered to start to use the computer game - "my diabetic friend" for the following 3 months.


Eligibility criteria:
inclusion criteria: 1. type 1 diabetes diagnosed at least one year prior to study entry. 2. age:7-11 years old. 3. treatment either with csii or mdi. 4. hba1c\>8.0% 5. signing an informed consent form. exclusion criteria: 1. any significant disease or conditions, including psychiatric disorders that in the opinion of the investigator are likely to affect subject compliance or subject's ability to complete the study. 2. inability to understand/ complete the questionnaires.

Keywords: type 1 diabetes "my diabetic friend" interactive computer game
an open prospective longitudinal pulmonary-cardiovascular cohort study

Conditions: Chronic Obstructive Pulmonary Disease; Cardiovascular Diseases; Lung Cancer

Summary: this is an observational study aiming to identify and validate biomarkers (including imaging and clinical descriptors) for chronic obstructive pulmonary disease (copd), cardiovascular disease (cvd) and lung cancer.


Eligibility criteria:
inclusion criteria: * 45-75 years

Keywords: prospective cohort study respiratory function tests computed tomography electrocardiography peripheral arterial disease