Kornimate/medical-research-clean huggingface dataset:
urdu version of copenhagen neck functional disability scale: reliability and validity study

Conditions: Disability Physical

Summary: * the objective of the research is to do translation and to culturally familiarize the copenhagen neck functional disability scale into the urdu language. * to investigate if the copenhagen neck functional disability scale is reliable and validate in the pakistani population with chronic neck pain. * to check the correlation with neck disability index, neck pain and disability scale.

the english version of the copenhagen neck functional disability scale will be translated into urdu and culturally adapted, as per a previous recommendation. the copenhagen neck functional disability scale will be given to participants who have consented, and would be chosen based on convenience sampling and inclusion and exclusion criteria. the inter-observer and intra-observer reliability of the copenhagen neck functional disability scale, neck pain and disability scale , and neck disability index will be evaluated in this study. on the same day, the questionnaire will be filled out created two times. an inter - observer assessment will be done with 2 hour break between distributions of questionnaires. the initial observer then will gather a third assessment over one-week period. for data entry and analysis, statistical package of social sciences version 23 will be utilized. internal consistency will be checked using the cronbach alpha value, and test retest reliability will be assessed using the intra-class coefficient.

Eligibility criteria:
inclusion criteria: * from 20 years old to 60 years old * participants with chronic neck pain * the patient having minimum cervical rom and pain. * patient not taking medicine. * no intervention between the test-retest assessments. exclusion criteria: to complete the forms because of a psychological impairment, history or presence of; * rheumatic diseases, severe articulation inflammation, and cardiac disease. * history of previous cervical or thoracic spine injury * any systematic disease with an unstable spine * illiteracy or lack of understanding of urdu language * the presence of neurologic or musculoskeletal disorders other than the neck condition.

Keywords: copenhagen neck functional disability scale urdu version reliability validity neck disability
a study to learn about the safety of besponsa injection in pediatric patients with acute lymphocytic leukemia.

Conditions: Acute Lymphocytic Leukemia

Summary: the purpose of this study is to learn about the safety of besponsa for pediatric patients. . besponsa is approved for treatment of relapsed or refractory cd22-positive acute lymphocytic leukemia for pediatric patients. a type of leukemia (blood cancer) that comes on quickly and is fast growing. in acute lymphocytic leukemia, there are too many lymphoblasts (early-stage white blood cells) in the blood and bone marrow. also called all. the registration criteria for this study are: * never used besponsa before * \<18 years at the start of treatment with besponsa all patients in this study will receive besponsa according to the prescriptions. patients will be followed up as follow. * treatment phase: from the day of treatment initiation (day 1) to day 28 post-treatment to collect information on safety (e.g., adverse events). * follow-up phase: from day 29 post-treatment to week 52 to collect information on vod/sos.


Eligibility criteria:
inclusion criteria: 1. patients with relapsed or refractory cd22-positive all 2. patients who have never used besponsa before 3. patients aged \<18 years at the start of treatment with besponsa exclusion criteria: * none
value of speckle tracking echocardiography inflammatory bowel disease patients

Conditions: Echocardiography; Inflammatory Bowel Diseases; Cardiac Function

Summary: value of speckle tracking echocardiography in early assessment of cardiac function in inflammatory bowel disease .

ulcerative colitis (uc) is a common form of inflammatory bowel disease (ibd) that consists of chronic inflammatory disorders of the colon and the small intestine with unknown etiology. chronic inflammation is the basis of complicated pathogenesis, and the course of the disease is often complicated by an immune response. malnutrition, malabsorption and the involvement of organs other than those of the gastrointestinal tract are frequent consequences of the disease . although extra-intestinal manifestations of ibd are common (ranging from 6% to 47%), cardiac involvement is rare. inflammatory bowel disease (ibd) is a known risk factor for cardiovascular disease (cvd). ibd patients have a two- to threefold increased risk of venous thromboembolism, particularly during acute flares when disrupted homeostasis of anti- and procoagulants leads to a hypofibrinolytic state. cardiovascular manifestations in crohn's disease (cd) and ulcerative colitis (uc) include conditions such as takayasu's arteritis, pericarditis, and myocarditis. chronic inflammation and altered lipid metabolism, along with long-term use of anti-inflammatory drugs (e.g., corticosteroids, tnf-α inhibitors), are thought to drive cv pathology in ibd. additionally, chronic inflammation is linked to pathological collagen deposition in affected organs. although conventional echocardiography is a widely accessible and easy tool to detect cardiac abnormalities, novel echocardiographic techniques and indices offer easy, reproducible and quantitative information for evaluating left ventricle function and subclinical changes . speckle tracking echocardiography (ste) is an advanced echocardiographic methodology for the quantification of myocardial function. ste has been successfully used to identify early subclinical cardiac involvement in a variety of asymptomatic populations with chronic diseases and unremarkable conventional echocardiography. unlike earlier echocardiography techniques, two-dimensional speckle tracking echocardiography (2dste) is less angle-dependent. in addition, ste is not affected by the rotation of the heart and allows heart functions to be examined segment by segment from various echocardiographic views . despite, studies have examined subclinical cardiac impairment in patients with ibd, to the best of our knowledge, none have explored the impact of ulcerative colitis activity on cardiac function through using ste.

Eligibility criteria:
inclusion criteria: * age (18-60) yrs. * both sexes. * patients with ibd either in active form or in remission. exclusion criteria: * patients with ischemic heart disease. -patients with other comorbidities affecting heart as uncontrolled hypertension or diabetes. - * pregnant females. * malignancy
balance, cognıtıve skılls, hand functıons and qualıty of lıfe among patients with bronchiectasis and healthy peers

Conditions: Bronchiectasis

Summary: the aim of this study is to comparatively evaluate the parameters of balance, cognitive skills, hand grip strength, reaction time, quality of life and respiratory functions in elderly and healthy peers individuals.

deterioration of airway patency, respiratory functions, experiencing shortness of breath that limits functional capacity, impairments in health-related quality of life, balance, cognitive skills, hand grip strength and reaction time parameters make physiotherapy approaches important in the treatment of bronchiectasis.

Eligibility criteria:
inclusion criteria: * clinically diagnosed with bronchiectasis and in stable condition, * no known systemic, orthopedic or neurological disease, * can walk, * volunteer for research, * able to cooperate, * elderly individuals aged 65 and over with bronchiectasis * healthy elderly individuals aged 65 and over exclusion criteria: * individuals under 65 years of age * individuals with fev1 values \< 40% * history of uncontrolled hypertension, arrhythmia and mi in the last month * having a history of lung or liver transplantation, * unstable angina, * those with serious cardiac problems such as advanced heart failure, * hemodynamically unstable cases, * those who have used antibiotics in the last three weeks, * those with acute exacerbation * those with insufficient awareness and cooperation, * those with pregnancy and malignancy, * those who have orthopedic or surgical problems that may prevent tests, * those who did not agree to participate in the research

Keywords: bronchiectasis elderly balance cognitive ability hand grip strength hand functions quality of life lower extremity muscle strength respiratory function parameters reaction time
effect of probiotic bifidobacterium bifidum prl 2010 in the prevention of atopic dermatitis in children

Conditions: Atopic Dermatitis

Summary: this study evaluates the effect of supplementation with bifidobacterium bifidum prl2010 during pregnancy in preventing atopic dermatitis in children. pregnant women with a history of atopy or family history of allergies will be randomized to receive either the probiotic or a placebo. outcomes include the incidence and severity of atopic dermatitis in infants up to 12 months of age.

atopic dermatitis (ad) is a growing public health concern due to its increasing prevalence and significant impact on quality of life. this randomized, double-blind, placebo-controlled pilot study investigates the efficacy of bifidobacterium bifidum prl2010 in preventing ad when administered during pregnancy. women aged 18-45 with a history of atopy or family history of allergies will be recruited and randomized into two groups: one receiving the probiotic and the other receiving a placebo. the intervention will begin at the 36th week of pregnancy and continue postpartum during breastfeeding for two months. infants will subsequently receive the same treatment from the 3rd to 6th month of life. outcomes include the presence and severity of ad assessed using the scorad index and additional allergy tests at 3, 6, and 12 months of age. this pilot aims to assess feasibility, safety, and initial efficacy data for future larger-scale studies.

Eligibility criteria:
inclusion criteria: * pregnant women aged 18-45 years. * presence of allergic manifestations or a positive family history of allergies. * normal pregnancy without complications (e.g., no risk of eclampsia or gestational diabetes). * residing in rome. * non-smoker and non-smoking partner. * absence of pets. * planning natural childbirth. * intention to breastfeed for at least 3 months. exclusion criteria: * complications during pregnancy (e.g., preterm birth before 36 weeks). * infants with necrotizing enterocolitis or congenital, chronic, or metabolic diseases. * immunodeficiencies in mother or child. * failure to meet any inclusion criteria during the study period.
ultrasound to evaluate failure of liberation from mechanical ventilation

Conditions: Acute Respiratory Failure; Respiration, Artificial; Weaning

Summary: this study will evaluate the heart, lungs and diaphragm of patients who fail a trial of spontaneous breathing to determine the physiological mechanism of weaning failure.

the transition to unassisted breathing after invasive ventilation often proves challenging, with over 40% of patients failing their first attempt of unassisted breathing. persistent ventilator dependence predisposes patients to nosocomial complications and increases the economic burden of critical illness. ventilator-dependence results from an imbalance between the load and capacity of the respiratory muscle pump. patients who fail a trial of spontaneous breathing commonly exhibit excess respiratory loads secondary to weaning-induced pulmonary edema, atelectasis or dynamic hyperinflation. many patients who are dependent on the ventilator also show a striking loss of pump capacity due to diaphragm dysfunction. though each of these mechanisms respond to specific interventions, it is often difficult for physicians to discern which mechanisms are at play at the bedside. bedside ultrasound is a potentially useful means of evaluating cardiac, pulmonary and diaphragm function during weaning failure. it is readily available, highly feasible and already widely employed in clinical practice. as yet, no study has evaluated the accuracy and feasibility of combining echocardiography with lung and diaphragm ultrasound to comprehensively evaluate the physiological mechanisms of weaning failure. the objectives of this study are to establish the utility of a rapid thoracic ultrasound exam to diagnose mechanisms of ventilation liberation failure and to assess the relationship between cardiothoracic variability during spontaneous breathing and different physiological mechanism of weaning failure.

Eligibility criteria:
inclusion criteria: * patients over 18 years of age receiving invasive mechanical ventilation for at least 24 hours * patients who fulfill standard criteria for readiness for a trial of spontaneous breathing (no or minimal sedation, patient awake and interactive; minimal vasopressor/inotrope requirements (norepinephrine \< or = 0.1, dopamine \< 10, vasopressin/epinephrine off); fraction of inspired oxygen \< or = 50%; spontaneous inspiratory efforts as indicated by patient-triggered breaths; positive end-expiratory pressure \< or = 10 cm h20) * patients who fail a trial of spontaneous breathing (transient reduction of ventilator support for any duration up to 2 hours as per local icu practice - typically ps 5 with peep 5 or cpap 5 or t-piece) exclusion criteria: * patients with a coagulopathy (inr \> 2.5, platelet count \< 30x10\^6/l) or previously diagnosed bleeding diathesis or are receiving anticoagulant drugs at therapeutic doses (ie. excluding venous thromboembolic prophylaxis) * patients with a contraindication to nasogastric tube insertion (esophageal varices, upper gi tract surgery, facial trauma, etc.) * patients receiving extra-corporeal life support
platelet function in patients with hemophilia a

Conditions: Hemophilia A

Summary: abnormalities in the gene encoding factor viii (fviii) results in hemophilia a, an x-linked recessive bleeding disorder with a prevalence of 1 in 5000 males. hemophilia a patients are classified into 3 different categories based on residual fviii activity compared to normal: mild (6-40%), moderate (1-5%) and severe (\<1%). this categorization correlates to some degree with bleeding phenotype, but does not completely define it. some patients with hemophilia a bleed less often than others despite identical plasma fviii levels. the cause(s) of this phenotype heterogeneity in hemophilia a remains largely unknown, despite a number of studies of possible factors. activated platelets, in addition to their role in primary hemostasis, play a major role in secondary hemostasis (coagulation) by providing a phospholipid surface to which coagulation factors bind. a role for platelets in the hemorrhagic propensity of hemophilia a has been suggested in the past, but only a small number of studies have been performed with limitations in assays performed and numbers of patients. the purpose of the present study is to determine whether platelet reactivity in severe hemophilia a patients is associated with past bleeding frequency and/or predicts future bleeding frequency.


Eligibility criteria:
inclusion criteria: * patients with severe hemophilia a who are being prophylactically treated with fviii. * age of at least 2 years. * bleeding history of at least 6 months. * irb-approved informed consent. exclusion criteria: * presence of fviii inhibitors. * greater than 7 days since active bleeding.

Keywords: severe hemophilia a coated platelets bleeding
the effect of mobile-based education and exercise program given to patients with total knee replacement surgery

Conditions: Replacement, Knee

Summary: total knee replacement (tdp) surgery is recognized as an effective surgical option for patients who develop moderate to severe osteoarthritis of the knee. before, during and after tdp surgery, patients experience physical, psychological and social problems. after tdp surgery, patients may experience problems such as dependency and sleep problems in their daily living activities. patients who have sleep problems, who cannot rest enough, become tired and experience anxiety as a result. it has been stated that the education given to the patients in the preoperative period reduces anxiety and analgesic needs and increases satisfaction. progressive relaxation exercises in patients it has been shown to be effective in reducing symptoms such as anxiety, pain and fatigue. with the widespread use of mobile technologies, a rapid development is observed in mobile health applications and it is thought that its use in the field of health will provide great benefits to nursing services. this study is of the randomized controlled experimental type. during the application process, a mobile-based training and exercise program will be applied to the patients in the experimental group. as the education content, information about pre- and post-operative information and video-supported training content that will guide the patients with voice commands about the exercises that the patients will do before the surgery will be included in the mobile application. with the implementation of this program, continuity will be ensured by meeting the information needs of the patients before and after the surgery, and by performing progressive relaxation and knee exercises correctly and regularly. with the use of this mobile application, it is aimed to increase the physical functions of the patients by reducing the level of anxiety and fear of movement.


Eligibility criteria:
inclusion criteria: * patients who were decided to undergo total knee replacement surgery with the diagnosis of osteoarthritis, * patients who will undergo elective surgery * patients who will undergo unilateral total knee replacement surgery for the first time * patients who can be communicated verbally * patients without any psychiatric disease * patients who use smartphones and agree to participate in the study exclusion criteria: * patients under the age of 18 * patients who have had previous total knee replacement surgery * patients who underwent total knee replacement with emergency surgery * patients who will undergo bilateral total knee replacement surgery * patients with a previous psychiatric diagnosis * patients with verbal communication disorders

Keywords: mobile based application progressive relaxation exercise knee exercise kinesiophobia patient education physical function sleep quality pain nursing
immersive virtual reality techniques on the effects on cognition in people with cancer

Conditions: Cancer; Cognitive Impairment

Summary: oncobrain aims to assess the effect of an innovative immersive virtual reality-based (ivr) intervention that includes cognitive, physical activity and mindfulness exercises in people diagnosed with cancer and chemotherapy-related cognitive deficits (crcd). the main objective of oncobrain is to determine the benefits of rvi intervention on the cognitive, and emotional state and quality of life of people with cancer and crqd. we hypothesize that in oncobrain we will find improvements in people with cancer and crcd who have received ivr stimulation compared to the control group with cancer and crcd who have not received ivr stimulation. people in the experimental group will perform better than patients in the control group in cognition (episodic memory, executive function, attention, and information processing speed), show better emotional well-being and perceive a better quality of life at the end of the intervention.


Eligibility criteria:
inclusion criteria: a. over 18 years of age and under 65 years of age b. diagnosis of cancer c. at least 4 weeks since the last chemotherapy treatment session d. presence of cognitive complaints after chemotherapy treatment e. level of primary education to be able to perform the cognitive tests. f. consent to participate in the study exclusion criteria: a. established diagnosis prior to cancer diagnosis of psychiatric, neurological, neurodevelopmental or systemic disorder causing cognitive deficits. b. motor or sensory impairments that preclude completion of the program. c. undergoing chemotherapy treatment
the correlation between forward head posture; neck pain, neck functional ability and deep neck core strength in jordan

Conditions: Forward Head Posture

Summary: is forward head posture correlated with neck pain, neck functional ability and deep neck core strength in jordanian university students having chronic nonspecific pain.

the study is an observational cross sectional study considering the effects of one of the most common spinal deformities such as forward head posture on the quality of life regarding jordanian university students. university students are among the most common populations having these kinds of deformities because of using smart devices and studying for along periods of time in a faulty posture. 60 students "both male and females" having forward head posture with neck pain will be included in the study and different outcome measure as pain , functional ability and deep neck core strength will be measured to define the impact of this faulty posture on them. pain measurement will be through using numeric rating scale for pain.

Eligibility criteria:
inclusion criteria: * the craniovertebral angle is less than 50 degrees . * age ranges from 18 to 25 years old * forward head is associated with neck pain. * studying hours more than 4 hours continuously per day exclusion criteria: * previous surgery regarding the spine or shoulders. * vertebral fractures regarding the cervical spine or the skull. * positive neurological signs or evidence of spinal compression. * headaches prior to the onset of neck pain and without cervical origin. * inner ear or vestibular problems.

Keywords: forward head posture neck pain jordanian university
closed aspiration on hemodynamic changes and pain

Conditions: Aspiration

Summary: the study was planned to determine the effects of closed aspiration on arterial blood pressure, heart rate, respiratory rate, oxygen saturation level and pain in intensive care patients connected to mechanical ventilators. ithe effects of the closed aspiration system on hemodynamic parameters and pain will be determined and the results will be important in terms of the usability of the closed system in the clinical environment and raising awareness in nursing practices in order to create minimum complications for the patient.

the research iss carried out in a single group pretest posttest quasi-experimental design in order to determine the effects of closed aspiration on arterial blood pressure, heart rate, respiratory rate, oxygen saturation level and pain in intensive care unit patients with mechanical ventilation. the research is carried out in anesthesiology and reanimation intensive care unit. the sample of the study is patients who was intubated, not sedated, systolic arterial blood pressure 110-140 mmhg, diastolic arterial blood pressure between 60-90 mmhg, heart rate between 60-100/min, respiratory rate between 12-20/min, oxygen with saturation level (spo2) \>86%. data is collected from the hospital's electronic patient record system and observationally before and after the aspiration. "patient description form", "hemodynamic status and pain monitoring form", "behavioral pain scale" is used to collect research data.

Eligibility criteria:
inclusion criteria: * over 18 years, * intubated * connected to mechanical ventilator, * not receiving sedation, * not unconscious, * monitored, * systolic arterial blood pressure is between 110-140 mmhg and diastolic arterial blood pressure is between 60-90 mmhg, * heart rate between 60-100/min, * respiratory rate between 12-20/min, * body temperature not higher than 38º c, * oxygen saturation level (spo2) \>86% exclusion criteria: * not intubated, * received a diagnosis related to the respiratory system, * unconscious or sedated curare

Keywords: closed aspiration pain hemodynamic parameters