Kornimate/medical-research-clean huggingface dataset:
effects of corticosteroid use on restoration of spontaneous circulation in cardiac arrest patients

Conditions: Cardiopulmonary Arrest; Corticosteroids Adverse Reaction

Summary: we aim to investigate the effects of pre-arrest corticosteroid use for any reason on the time of return of spontaneous circulation in patients experiencing witnessed cardiac arrest, either in-hospital or out-of-hospital. additionally, we plan to study the effects of corticosteroid use on post-rosc administration of vasoactive agents, required dosage of vasoactive agents and number of vasoactive agents needed in order to reach targeted blood pressure levels.

patients will be collected from etlik city hospital emergency medicine department. patients presenting with witnessed cardiac arrest, either in-hospital or out-of-hospital, will be enrolled in our study. inclusion criteria: age 18 and above witnessed cardiac arrest exclusion criteria: traumatic cardiac arrest forensic cases cardiac arrest secondary to st-elevation myocardial infarction patients in whom spontaneous circulation could not be achieved despite cardiopulmonary resuscitation lasting more than 20 minutes patients with inaccessible past medical records or unknown medication history patients without identification unwitnessed cardiac arrest pregnant patients patients will be divided into two groups: the first group will consist of 23 patients who used corticosteroid medications for any reason before experiencing cardiac arrest. the second group will consist of 23 patients who did not use corticosteroid medications before cardiac arrest. following successful cardiopulmonary resuscitation and restoration of spontaneous circulation, the following parameters will be recorded for both groups: need for vasopressor support, number of vasopressor agents used, maximum dose of vasopressor agent(s) required to maintain mean arterial pressure (map) \>65 mmhg, duration of stay in intensive care unit/emergency department, mortality rate, length of hospital stay, patients' medical histories, age, and gender. these parameters will be compared between the corticosteroid-using and non-using groups, and statistical analysis will be conducted to evaluate differences between the two groups

Eligibility criteria:
inclusion criteria: age 18 and above witnessed cardiac arrest exclusion criteria: traumatic cardiac arrest forensic cases cardiac arrest secondary to st-elevation myocardial infarction patients in whom spontaneous circulation could not be achieved despite cardiopulmonary resuscitation lasting more than 20 minutes patients with inaccessible past medical records or unknown medication history patients without identification unwitnessed cardiac arrest pregnant patients

Keywords: cardiac arrest, corticosteroids use,
effect of early compression and exercise on lymphedema incidence in patients with gynecological cancer

Conditions: Genital Neoplasms, Female; Lymphedema

Summary: objectives: 1) to evaluate the effect of early compression therapy with individualized exercise on the incidence of lower limb lymphedema at 12 months post-operatively in patients treated for gynecological cancer who are at risk of developing lymphedema; 2) to evaluate the effect of early compression therapy with individualized exercise on lower limb volume, quality of life and incidence of cellulitis infections at 12 months post-operatively in this population.

study design and setting: a pilot randomized controlled trial will be conducted on 50 patients with gynecological cancer recruited from the mcgill university health centre (muhc) royal victoria hospital and the jewish general hospital (jgh) segal cancer centre in montreal, quebec. the data collection and interventions will be conducted at the muhc lymphedema support centre. intervention: at 4-6 weeks post-operatively, each participant in the experimental group will be prescribed jobst elvarex compression class 1 (18 to 21 mmhg) standard or custom-made stockings for both lower limbs with or without panty. the participants will be recommended to wear the garments for 12 to 16 hours daily for at least 6 months post-operatively. at this time, the participants will also receive individualized education on exercise, self-lymphatic drainage and skin care by an unblinded lymphedema therapist. control: at 4-6 weeks post-operatively (t2), both groups will receive standard education on lymphedema risk reduction along with printed materials from the lymphedema association of quebec.

Eligibility criteria:
inclusion criteria: * above 18 years of age; * diagnosis of grade 2 or 3 endometrial cancer, or high grade type (serous or clear cell), stage 1b1 or stage 2a cervical cancer, stage 1 vulvar cancer with tumor greater than 4 cm, or stage 2 or 3 vulvar cancer; * to undergo surgical lymph node dissection. exclusion criteria: * recurrent diagnosis of gynecological cancer; * presence of distant metastases (stage 4 cancer); * body mass index of 35 or greater.
researching the effects of airway clearance therapies in cystic fibrosis

Conditions: Cystic Fibrosis; Mucociliary Clearance Defect

Summary: this is a pilot study investigating the effectiveness and clinical efficacy of airway clearance therapy (act) in cystic fibrosis (cf). enrolled subjects will undergo measurements of mucociliary clearance (mcc) and exhaled biomarkers at baseline and after 3 different forms of act: high frequency chest wall oscillatory vest, oscillatory positive expiratory pressure device, and whole-body vibration.


Eligibility criteria:
inclusion criteria: * adults with confirmed diagnosis of cystic fibrosis aged 18 years and older. exclusion criteria: * pregnant or lactating women, * individuals with severe lung disease (fev1 \<30%), or with exacerbations of lung disease requiring antibiotics or medication change within four weeks prior to enrolment. * individuals unable to use vest-based hfcwo, opep device, or who require oxygen supplementation at rest. * individuals with significant balance or gait impairment preventing them from tolerating being positioned on a vibrating platform.
sleep timing and circadian preferences in a sample of egyptian patients with hepatic cirrhosis

Conditions: Liver Cirrhosis

Summary: individuals with hepatic cirrhosis (n=50) and healthy controls (n=30) were recruited. sleep quality, sleep timing parameters and circadian preference were evaluated using the pittsburgh sleep quality index (psqi), sleep timing questionnaire (stq) and the composite scale for morningness (csm) respectively

cirrhosis of the liver is a chronic, diffuse, degenerative disease in which the parenchyma deteriorates, the lobules are infiltrated with fat and structurally altered, dense perilobular connective tissue forms and often areas of regeneration develop. these regeneration nodules have a reduced blood supply resulting in impaired liver function \[1\] and \[2\]. factors that are taken into account to determine the severity of cirrhosis include serum albumin, prothrombin concentration, serum bilirubin, ascites and encephalopathy. a point system known as the child's-pough-turcotte score has been designed to determine the severity of cirrhosis. depending on the total score, patients are classified as class a (early cirrhosis) through class c (advanced cirrhosis) \[3\]. a disturbance of sleep is recognized as one of the early signs of hepatic encephalopathy. reversal of sleep rhythm, drowziness and lethargy are classic signs of this disease. sleep disturbance and excessive daytime somnolence are common in patients with cirrhosis. it was estimated that up to 70% of individuals with cirrhosis (regardless of etiology) experience sleep disturbances \[4\]. difficulty falling asleep and a shift in sleep schedule toward the latter part of the night, which might be result in daytime sleepiness, are commonly reported findings in patients with hepatic cirrhosis without encephalopathy \[4\]. individuals with hepatic cirrhosis (n=50) and healthy controls (n=30) were recruited. sleep quality, sleep timing parameters and circadian preference were evaluated using the pittsburgh sleep quality index (psqi), sleep timing questionnaire (stq) and the composite scale for morningness (csm) respectively

Eligibility criteria:
inclusion criteria: * liver cirrhosis * controls exclusion criteria: * hcc
hamstring active release technique in cervicogenic headache

Conditions: Cervicogenic Headache

Summary: it has been suggested that the suboccipital muscles are a causative factor in both cervicogenic neck pain and headache. hamstrings and sub-occipital muscles are connected by a neural system and sub-occipital muscles pass through the dura mater. increased tension and shortening of the hamstring's muscles can cause neck and shoulder pain. in addition, when the muscles around the neck are tensed, the muscles in the limbs are also tensed, so that if the tone of the hamstring muscles is decreased, slr test score increased, and the tone of the sub-occipital muscles is reduced. active release technique is found to have an effect on hamstring flexibility.

cervicogenic headache (cgh) is a secondary and often unilateral headache that is known by referring pain from soft or hard cervical structures to occipital, temporal and frontal regions. there are some fascial connections between suboccipital muscles with dura mater and c2 vertebra. presumably, fascial restriction in one part of the body causes unusual stress in other parts of the body due to fascial continuity. it has demonstrated that increased tension and shortening of the hamstring's muscles can cause neck and shoulder pain. this occurs because the superficial fascial back line of the myofascial chain connects from the neck to the lower extremity, and the soft tissue in the cervical spine links the dura and suboccipital muscle fascia. therefore, it is probable that if the tone of the hamstring muscles is decreased (passively, with a fascial treatment or with active movements), the tone of the knee flexors (hamstring muscles) is reduced and the amplitude of hip flexion is increased, thereby increasing the straight leg raise (slr) test score. active release technique (art) is a type of manual therapy used for treating soft tissue injuries. problems with muscles, tendons, ligaments, fascia and nerves are successfully treated with it and is found to have an effect on hamstring flexibility.

Eligibility criteria:
inclusion criteria: * unilateral headache (in the same side) related by pain, movement and sustaining position of neck started from the occiput spread to the tempro-frontal region for more than 3 months. * pain and tenderness at the upper cervical segment's palpation. * movement restriction in cervical region, especially in the upper cervical rotation. * positive slr test for hamstring muscle less than 80◦. exclusion criteria: * malignancy. * other types of headaches, including migraine, tension type, other serious headaches. * history of head and neck trauma or surgery. * pregnancy. * physiotherapy for headache in the last 3 months.

Keywords: active release technique and cervicogenic headache
effects of medications in patients with hypogonadism

Conditions: Idiopathic Hypogonadotropic Hypogonadism

Summary: the aim of the present study was to demonstrate the influences of three different treatment strategies on biochemical parameters and testicular volume (tv) in patients with idiopathic hypogonadotropic hypogonadism (ihh).


Eligibility criteria:
inclusion criteria: hypogonadotropic hypogonadism * decreased serum testosterone concentration below the normal range (serum t \< 300ng/dl), * fsh and lh levels within or below the normal range, * absence of a pituitary or hypothalamic mass lesions on mri, presence of gonadotropin response to repetitive doses of gnrh, * normal smell test and normal karyotypes exclusion criteria: * previous androgen treatment, * history of smoking, * presence of bilateral anorchia, * intellectual deficiency, * diabetes mellitus, * arterial hypertension or dyslipoproteinemia, * medication of any kind and drug abuse. because of possible confounding effects, patients with other hormone deficiencies were excluded. participants with iron, vitamin b12 or folate deficiency were also excluded.

Keywords: hypogonadism treatment testis volume
dynamic balance, flexibility and agility as predictors of lower-extremity injury in football players

Conditions: LOWER-LIMB INJURY

Summary: this research investigates the reliability of tests to assess injury risk. participants will be tested at the beginning of the survey and will be monitored for over 5 months. participants will take 4 types of tests related to dynamic balance, flexibility, and agility. subsequently, the relationship between test results and the incidence of injury in the subjects will be analyzed. if the tests prove reliable, they will be included in standard tests to assess the risk of injury to football players.

too often, injuring athlete results in a large amount of money being spent on rehabilitation. in a world of sports where the speed of recovery means a lot, ways are sought first and foremost to minimize the frequency of non-contact injuries. to prevent certain things, it is important to know the initial state, therefore, to see if certain factors at the outset indicate to us that there is a certain imbalance that can result in the injury. since we live in a country where sports clubs are unable to spend large amounts of money on rehabilitation, it would be of great benefit to find reliable tests that can help to prevent an injury. studies have shown that tests of balance, flexibility, and agility can help to prevent injury to football players in other countries. the same tests will be applied to premier league footballers in bosnia and herzegovina and their effectiveness in assessing the degree of risk of lower limb injuries will be tested. if they prove reliable, they can become a standard in the prevention of these injuries, that is, they will help in the development of injury prevention programs, which would be of great benefit to both clubs and football players. the study aims to determine whether dynamic balance and flexibility tests can be used as reliable predictors of lower limb injuries in football players and whether reduced agility influences the increased risk of injury.

Eligibility criteria:
inclusion criteria: * professional players * age above 18 years * voluntary access to research exclusion criteria: * age under 18, * refusal to take the research, * remaining in the club until the end of the examination, * errors in keeping records of injuries by responsible persons, * injuries to the lower limbs in the last ten days, * vestibular disorders.

Keywords: dynamic balance stretching flexibility agility
influence of circulating endothelial progenitor cells and modifiable vascular risk factors on carotid plaque vulnerability

Conditions: Atherosclerosis; Stroke; Inflammation

Summary: ischemic stroke is a leading cause of death and disability worldwide. atherosclerosis, responsible for the 20% of ischemic strokes, is characterized by lipid accumulation in the artery wall that leads to chronic inflammation, cell proliferation and ultimately to vessel stenosis. one of the main features related to plaque progression and vulnerability is inflammation. positron emission tomography with 18-fluorodeoxyglucos (18-fdg pet) allows an accurate quantification of plaque inflammation and it has been proved its usefulness in predicting early stroke recurrences. the investigators aim to test how modifiable vascular risk factors influence plaque inflammation assessed by 18-fdg pet. in addition, investigators will assess the association of this inflammation and circulating endothelial progenitor cells


Eligibility criteria:
inclusion criteria: * ischemic stroke within 7 days before inclusion * at least one atherosclerotic plaque in the internal carotid artery * \>18 years old exclusion criteria: * cardioembolic strokes according to toast criteria * poor functional outcome (rankin \>3) after stroke
the effect of preoperative warming on postoperative hypothermia

Conditions: Preventing Hypothermia; Perioperative Hypothermia

Summary: 36 patients american society of anesthesiology (asa) physical status i,ii and iii undergoing general anesthesia for elective transurethral resection of the prostate (tur-p) surgery will be included in the study. patients will be randomized into two groups; first group(control group) and second group (forced-air warming). resistive heating will start when patients are transferred to the operating room table; forced-air warming will start before preoperative 30 minute.

the primary aim of this study was to compare the effect of prewarming on perioperative hypothermia in elderly patients undergoing turp under general anesthesia. in addition, we aimed to evaluate the effects of prewarming on hemodynamic variables, pacu output time, tremor, patient comfort and satisfaction. the investigators plan to enroll 36 patients in 2 groups. body temperature will be measured at the core temperature, hemodynamic variables. shivering will be graded by visual inspection. thermal discomfort scale, patient satisfaction will be evaluated. the investigators hypothesize will decrease the forced air prewarming incidence of perioperative hypothermia.

Eligibility criteria:
inclusion criteria: * patients aged 50-85 years undergoing general anesthesia for turp surgery * asa physical status i and iii patients * body mass index between 15 and 36 kg/m2 * general anesthesia time is 30-90 minutes exclusion criteria: * without written consent, * inadequate turkish comprehension, * known impaired thermoregulation or thyroid disorders, * severe hypertension (systolic blood pressure \[sbp\]\>180 mmhg or diastolic blood pressure \[dbp\] \> 110 mmhg in the operating suite admission), * an angiotensin-converting enzyme inhibitor/angiotensin ii receptor antagonist on the day of surgery, * secondary hypertension (e.g., renal artery stenosis, pheochromocytoma, cushing's syndrome), * vascular disease, * poor cutaneous perfusion, * serious skin lesions * baseline temperature ≥37.5°c (degrees centigrade)

Keywords: forced-air hypothermia tur-p surgery core temperatures prewarming general anaesthesia
multi-center pampa study

Conditions: Psoriasis

Summary: this is a multi-center (north-america), randomized, double-blind, placebo-controlled, wait-list, interventional, preventive trial of guselkumab in high-risk psoriasis patients compared to non-biologic standard of care. the primary objective of the proposed trial will be to test the hypothesis that a prolonged, unresolved skin inflammation coupled with musculoskeletal power-doppler ultrasound (mskpdus) abnormalities driven by il-23 increase the risk for transition into psa and that an intervention that targets one of these pivotal molecules (i.e., guselkumab) will: 1. diminish mskpdus findings at 24 weeks, and 2. significantly reduce or prevent the emergence of synovio-enthesial phenotype at year 2.


Eligibility criteria:
inclusion criteria: 1. 18 years old or older; 2. both male \& female; 3. psoriasis diagnosis (per dermatologist) for at least 2 years (in at least 30% of participants); 4. willing and able to provide informed consent; 5. fulfillment of hr-pso criteria (psoriasis (pso) patients will meet the definition of hr if they fulfill the following criteria: a) pso duration \>2 years and psoriasis body surface area (bsa) \>3% and positive imaging findings in mskpdus defined as a rm-psason score of \>3.36 exclusion criteria: 1. evidence of inflammatory joint pain, enthesitis and/or dactylitis on exam; 2. current systemic immunosuppressive medication use (i.e., methotrexate, apremilast) at the time of enrollment or biologic therapy (ever); 3. ra seropositivity (mid-high rf/acpa titers); 4. current active malignancy; 5. history of symptomatic polyarticular oa or other joint conditions (such as ra, gout, etc) that may impair the ability to assess for psa development 6. conditions where initiation of guselkumab is prohibited in the prescribing information, including clinically important active infection and untreated latent tuberculosis; 7. known hypersensitivity to the study agent.
study of intravenous covi-msc for treatment of covid-19-induced acute respiratory distress

Conditions: Covid19

Summary: this is a phase 2 randomized controlled study to assess the safety and efficacy of covi-msc in the setting of current standard of care treatments for covid-19 infection in hospitalized subjects with acute respiratory distress syndrome.

this is a phase 2 randomized controlled study to assess the safety and efficacy of covi-msc in the setting of current standard of care treatments for covid-19 infection in hospitalized subjects with acute respiratory distress syndrome. covi-msc or placebo will be administered intravenously on day 0, day 2, and day 4. acceptable standard of care treatments for covid-19 include all approved or emergency use authorized treatments for covid-19, even if used off-label.

Eligibility criteria:
inclusion criteria: * laboratory-confirmed sars-cov-2 infection as determined by an approved polymerase chain reaction (pcr) or an approved antigen test of any specimen * hospitalized with covid-19-induced ard or ards (any severity) with a pao2/fio2 (pf ratio) ≤ 300 * requires oxygen supplementation at screening * willing to follow contraception guidelines exclusion criteria: * current standard of care treatments for covid-19 appear to be working and the subject is clinically improving * a previous stem cell infusion unrelated to this trial * certain medical conditions that pose a safety risk to the subject * pregnant or breast feeding or planning to during the study * suspected uncontrolled active bacterial, fungal, viral, or other infection * history of splenectomy, lung transplant, or lung lobectomy * concurrent participation in another clinical trial involving therapeutic interventions * expected survival or time to withdrawal of life-sustaining treatments expected to be \<7 days * has an existing "do not intubate" order * has undergone home mechanical ventilation (noninvasive ventilation or via tracheotomy) expect for continuous positive airway pressure or bi-level positive airway pressure (cpap/bipap) used solely for sleep-disordered breathing

Keywords: covid-19
hemophilia inhibitor previously untreated patient study

Conditions: Hemophilia A

Summary: hemophilia a is a congenital bleeding disorder caused by deficiency of factor viii (fviii) and is treated by replacement therapy with fviii concentrate. approximately 30% of people with severe hemophilia a develop neutralizing antibodies, called fviii inhibitors, which interfere with the function of fviii concentrates. the reason that some, but not all, people with severe hemophilia a develop inhibitors is incompletely understood. understanding individual and environmental risk factors is important to be able to prevent and possibly treat inhibitors. this study will look at individual and treatment characteristics in babies with severe hemophilia a who have not yet received treatment with fviii (called previously untreated patients, or pups). subjects in the study will be asked to provide diaries of treatments, medications, and illnesses. treatment will be directed by the subjects' physician, but all subjects will receive advate, a third-generation recombinant fviii product. subjects will have blood drawn for laboratory tests, which include studies of the immune system and genetic studies of the fviii mutation, before and 7-9 days after the first treatment with fviii, and 5 days (+/-2 days) after the 5th, 10th, 20th, 30th, 40th, and 50th days of treatment with fviii (exposure days). the duration of the study will be first 50 treatments or 3 years, whichever comes first.


Eligibility criteria:
inclusion criteria: * severe hemophilia a with fviii activity \< 1% normal * weight \> 3.5 kg at the time of baseline study evaluation * informed consent, approved by appropriate institutional review board/independent ethics committee, has been administered, signed, and dated exclusion criteria: * prior exposure to clotting factor concentrates or blood products * other chronic disease * currently participating in another investigational drug study.

Keywords: fviii inhibitors