Kornimate/medical-research-clean huggingface dataset:
massage percussion for passage of urolithiasis fragments after ureteroscopy.

Conditions: Nephrolithiasis

Summary: flexible ureteroscopy is characterized as first-line therapy for renal stones \< 2 cm in size. stones are commonly treated with dusting or fragmentation techniques which requires passage of stone fragments after surgery. quoted stone free rate after flexible ureteroscopy is approximately 40-60% with a dusting technique. residual fragments are often under 1mm in size and can layer in the lower pole of the kidney, complicating spontaneous stone passage. improving the stone free rate after surgery decreases the need for secondary surgeries and decreases risk of future stone events. numerous techniques have been proposed to increase stone passage including positional changes and percussion therapy. to date, there is overall limited data a lack of techniques that can be readily available in the outpatient setting, easily added to scheduled appointments, reproducible results and well tolerated by patients.

researchers in china have developed a proprietary oscillation machine to be used in an outpatient setting. the external physical vibration lithecbole (epvl) is used to provide vibration after stone fragmentation to facilitate movement of fragments into a more favorable orientation for stone passage. after extracorporeal shockwave lithotripsy and ureteroscopy, use of epvl after surgery has been shown to increase stone free rate. chest percussion for cystic fibrosis patients has been adapted for use after ureteroscopy. after undergoing extracorporeal shockwave lithotripsy, patients are placed in a percussion physiotherapy vest, given diuretics and positioned in trendelenburg. imaging obtained before and after percussion demonstrates successful stone movement and increases stone free rates in several different protocols compared to patients who do not receive percussive therapy. percussion therapy is clearly effective to improve stone free rates after ureteroscopy and is effective regardless of technique, protocol, or percussive device. however, proposed techniques with epvl and chest physiotherapy vests can be expensive, cumbersome and require specialty equipment. in addition, proposed equipment in prior studies is not readily available in outpatient clinics.

Eligibility criteria:
inclusion criteria: * any patient after treatment of renal stones with ureteroscopy during which residual stone fragments (less than 2mm by surgeon estimation) is left in the kidney. * must be 18 years or older * must be able to give consent * preoperative abdominal ct exclusion criteria: * on pharmacologic anticoagulation. aspirin up to 81mg will be allowed. * cannot tolerate flank, prone or trendelenburg position. * cannot tolerate percussion. * history of acute rib fractures or osteopenia/osteoporosis. * any patient who is on a fluid intake restriction. * pregnancy * untreated uti * history of struvite stones * requiring a planned secondary stone procedure within 90 days * if stent must stay in longer than 10 days * ureteral stones (without renal stones)
application of vitamin e on anal fissure

Conditions: Pain

Summary: patients were randomized into 2 groups: * vitamin e: vitamin e ointment will be applied during 8 weeks * nitroglycerin: nitroglycerin ointment will be applied during 8 weeks healing rate of chronic anal fissure in patients receiving nitroglycerin ointment and subjects patients receiving vitamin e ointment were evaluated .

patients were randomly assigned to experimental and control groups: those patients receiving vitamin e ointment (experimental group - eg) and those receiving glyceryl trinitrate ointment (control group - cg). treatments: glyceryl trinitrate ointment (gto): commercially available aluminium tubes containing 0.4 glyceryl trinitrate ointment (rectogesic, prostrakan group, galashiels, uk) were purchased from pharmacies. the dosage for all the patients was 375 mg of ointment (containing 1.5 mg of glyceryl trinitrate), applied with a gloved finger to the distal anal canal, every 12 hours for an 8-week period. vitamin e acetate ointment (vea): commercially available plastic tubes containing vitamine acetate ointment (filme olio, hulka srl, italy) were purchased from pharmacies. the dosage for all the patients was 1ml, applied with a gloved finger to the distal anal canal, every 12 hours for an 8-week period. healing rate of chronic anal fissure was investigated.

Eligibility criteria:
inclusion criteria: * patients with diagnosis of chronic anal fissure exclusion criteria: * patients with associated anal pathologies * intestinal inflammation disorders * immunosuppression * fissures secondary to underlying diseases (eg, aids, tuberculosis, or sexually transmitted diseases) * patients with a history of headaches, heart disease, or intolerance to nitrates * pregnant or lactating women * patients with closed angle glaucoma
symptoms of acute coronary syndrome in medical regulation

Conditions: Acute Coronary Syndrome

Summary: the main objective was to analyze the impact of the gender of the attending physician in the differences in the management of st+ acs between men and women. this study will be conducted in partnership with the interventional cardiology team of the chr metz-thionville and samu (emergency call center) of moselle, which has a detailed registry of coronary angiographies at the center. a retrospective observational study will be carried out over a "typical" period outside of covid at the chr metz mercy (2021-2022) based on coronary angiographies performed in the context of st+ acs at the chr of patients referred by the center 15. the patient's medical record will be analyzed, going back to his call to the 15 via tape listening. the number of subjects required being calculated at 104 men and 104 women, these patients will be selected from the database of our cardiologist colleagues and we will match one man to one woman by comparing the delays of several items (1st medical contact, time of 1st ecg, medicalization or not, delay of call to the cardiologist, delay of coronary angiography...) according to the sex of the regulator. the consequences of a difference in management will be also evaluated by analyzing in-hospital mortality, mortality at 30 days of management, and functional sequelae at discharge (grades of dyspnea, disturbance of myocardial contractility, lvef at discharge). this study based on the differences in questioning according to the gender of the regulating physician would allow better identification of the factors that increase the delay in the management of st+ acs in women, and to find avenues of correction in order to limit the loss of opportunity for patients. the patients included who are still alive will receive a notification of non-objection by mail.


Eligibility criteria:
inclusion criteria: * patient with emergency coronary angiography for st+ acs * having made a call to the emergency center for the same reason exclusion criteria: * non-real st+ acs

Keywords: acute coronary syndrome out-hospital care medical regulation
a trial of the urine lam strip test for tb diagnosis amongst hospitalized hiv-infected patients

Conditions: Tuberculosis

Summary: the novel urine lam point-of-care strip test offers potential clinical utility to improve tb diagnosis in hiv co-infected patients. urine lam strip test performance improves with increasing illness severity and more advanced immunosuppression, thus offering the greatest potential utility in hospitalised hiv-infected patients with advanced immunosuppression (cd4 cell count less than 200). however, in the context of high rates of empiric treatment and the availability of other novel tb diagnostics, the clinical impact of the urine lam strip test is unknown. this study will investigate the impact of the urine lam strip test. the study hypothesis is that the urine lam strip test, when combined with standard tb diagnostics (smear microscopy and culture) will significantly improve tb treatment-related outcomes (tb-related mortality, morbidity and length of hospital stay) in hiv-infected hospitalized patients when compared to standard tb diagnostics alone.


Eligibility criteria:
inclusion criteria: * hiv-infected (1x rapid hiv test positive) * considered tb suspect by attending doctor (must comprise at least 1 of the following: current fever or cough, drenching night sweats, self-reported low) * illness severity sufficient to warrant hospitalization * ≥18 years old * provision of informed consent exclusion criteria: * hiv-uninfected * patients receiving any anti-tb medication in the 60 days prior to testing * unable to provide 30mls urine * inability to provide informed consent

Keywords: urine lam strip test diagnostics tuberculosis
dose-ranging trial of inhaled cannabis for acute migraine treatment

Conditions: Migraine; Cannabis; THC

Summary: this pilot crossover study will evaluate 3 different potencies of inhaled cannabis (2.5%, 5%, and 10%) and inhaled placebo cannabis for the acute treatment of migraine.

in this double-blind, randomized, crossover trial, subjects will treat 4 separate migraine attacks with 4 different treatments. inhaled cannabis will be administered using a portable system. subjects will self-administer inhaled cannabis as early as possible in the course of a migraine, taking 4 puffs of 1) thc 2.5%, 2) thc 5%, 3) thc 10%, or 4) placebo. patients will treat each of the 4 distinct migraine attacks with a different cannabis sample. outcomes measured will include pain freedom, most bothersome symptom (mbs), and pain relief as well as presence or absence of photophobia, phonophobia, and nausea at 15 minutes, 30 minutes, 45 minutes, 1 hour, 1.5 hours, 2 hours, 4 hours, 24 hours, and 48 hours.

Eligibility criteria:
inclusion criteria: * age ≥ 21 and ≤ 65 * able to communicate in english * migraine, with or without aura, in its episodic or chronic manifestations, as per the international headache society (ihs) classification international classification of headache disorders (ichd-3) criteria (section 1.1, 1.2, 1.3).(48) * ability to provide informed consent and complete website questionnaires in english * agrees not to use cannabis outside of the study during participation in the study * agrees not to use opioids or barbiturates during participation in the study * agrees not to drive a motor vehicle within 4.5 hours following last use of inhaled cannabis during participation in the study exclusion criteria: * positive urine drug test for thc, barbiturates, opioids, oxycodone, or methadone prior to enrollment * pregnancy * breastfeeding * prisoner * known cognitive impairment * institutionalized * current moderate-severe or severe depression * current or past history of bipolar depression, schizophrenia, or psychosis * current or past history of cannabis, alcohol, opioid, or amphetamine abuse or other substance use disorder at the discretion of the research team * active pulmonary disease, class iv heart failure, cirrhosis, or other severe medical illnesses at the discretion of the research team. * allergy to cannabis

Keywords: migraine cannabis thc
automatic evaluation of inflammation activity in ulcerative colitis using pcle with artificial intelligence

Conditions: Ulcerative Colitis; Artificial Intelligence; Confocal Laser Endomicroscopy

Summary: probe-based confocal laser endomicroscopy (pcle) is an endoscopic technique that enables to evaluate the inflammation activity of ulcerative colitis with excellent correlation with histopathology. however this requires much experience, which limits the application of pcle. the investigators designed a computer-aided diagnosis program using deep neural network to make diagnosis automatically in pcle examination and contrast its performance with endoscopists.


Eligibility criteria:
inclusion criteria: * aged between 18 and 80; diagnosed as uc exclusion criteria: * patients under conditions unsuitable for performing cle including coagulopathy , impaired renal or hepatic function, pregnancy or breastfeeding, and known allergy to fluorescein sodium; inability to provide informed consent
molecular classification of endometrial cancer: impact on adjuvant treatment planning.

Conditions: Endometrial Cancer

Summary: molecular classification that has been recently incorporated in figo classification of endometrial cancer is a new triage tool for the better management of endometrial cancer patients.


Eligibility criteria:
inclusion criteria: * histological confirmation of endometrial cancer. * surgical treatment at our gynecological - oncology unit. exclusion criteria: * refusal to be tested for the molecular classification * presence of a synchronous neoplasm.
effect of epa-dha supplement, life style modification standard treatment on clinical outcome lipid membrane composition in type 2 diabetes

Conditions: Type 2 Diabetes

Summary: the aim of the present study is: to examine some of the mechanisms by which a change in life style alone or supplemented with a diet supplemented in n-3 pufa, and associated with this computerized life style regulation reduces the development of diabetic complication in a small population based study. (the newme™ / eco-fusion, ltd is a science-driven lifestyle change program for better living -www.eco-fusion.com)


Eligibility criteria:
inclusion criteria: 1. participants between 18-80 years of age. 2. have been diagnosed with type 2 diabetes more than nine months before study entry, and, despite having been given standard dietary advice by dietitian, doctor, or nurse and prescribed oral hypoglycaemic agents, insulin, or both. 3. have persistent unsatisfactory glycaemic control defined as hba1c more than 7%. 4. participants should have at least two of the following three characteristics: 1. overweight or obesity (body mass index ≥25), 2. hypertension (currently prescribed antihypertensive drugs or blood pressure \>140/90 mm hg despite optimized antihypertensive drug treatment), 3. dyslipidaemia (currently prescribed lipid modifying drugs) or one or more of: 1. total cholesterol \>5.2 mmol/l, 2. low density lipoprotein cholesterol \>3.5 mmol/l, 3. triglycerides \>2.0 mmol/l, 4. high density lipoprotein cholesterol \<1.0 mmol/l (despite optimised lipid modifying drug treatment). exclusion criteria: 1. pregnancy 2. serious chronic illness.e.g cancer 3. end stage renal failure 4. amputation 5. stroke 6. severe retinal microangiopathy 7. pancreas transplantation 8. hba1c \<7% 9. requires diet only treatment 10. they are too busy with work
culturally appropriate nutrition communication for mexican american women

Conditions: Lifestyle Risk Reduction; Nutrition Poor; Chronic Disease; Obesity; Cancer, Breast

Summary: a randomized controlled trial to test the effects of culturally appropriate nutrition communication for mexican american women.

an unbalanced randomized controlled trial with pre-test and immediate post-test was employed to test the effects of different types of message features and appeals. the study was conducted online with mexican american women aged 18-29 years old. messages focused on sugary beverage consumption and the main outcomes were acceptance and receptivity to the message (i.e., perceived effectiveness), perceptions of social norms, and knowledge. the investigators also measured a number of hypothesized mediators and moderators of the effects.

Eligibility criteria:
inclusion criteria: * self-identify as latina/x or hispanic * self-identify as a woman * self-reported as being of age between 18-29 years * undergraduate students enrolled in sona at uc merced exclusion criteria: - not mexican american

Keywords: sugar sweetened beverages health communication values-based messages latinas latinx hispanic experiment message testing tailoring
total knee arthroplasty and augmented reality-based navigation system

Conditions: Gonarthrosis

Summary: the purpose of total knee replacement (tkr) is to remove worn cartilage surfaces and replace them with artificial parts of the same shape. tkr can be used in cases of osteoarthritis, inflammatory rheumatism, bone necrosis of the knee or following malformative or traumatic sequelae. implant alignment is paramount in tkr and the last years have seen a proliferation of alignment techniques following the introduction of computer and robotic-assisted surgery. among computer-assisted surgery, the augmented reality-based navigation system can be an option to improve accuracy in orthopaedic surgery. the hypothesis of this study is: the use of augmented reality-based navigation system allows a prosthesis alignment and positioning that is at least as good as with the traditional mechanically aligned technique, and therefore improves knee functional results. this study also aims at assessing the cost-effectiveness of this new technology.

in this randomised study, tkr will be performed either with the traditional mechanically aligned technique or with an augmented reality-based navigation system using knee+ technology. knee+ is a class im software medical device (european classification, directive 93/42/eec, annex ix) and obtained ce mark 0459 in may 2020. this technology is used in total knee replacement procedures, and offers the orthopedic surgeon intraoperative assistance in positioning the implants with the help of a pair of augmented reality glasses. the cutting planes are oriented with respect to the mechanical axes calculated according to anatomical landmarks acquired with a pointer. the connected glasses calculate precisely the 3d coordinates of the instruments thanks to the analysis of their specific markers (qr-code), filmed by the integrated camera. the navigation information is displayed in the surgeon's field of vision, who interacts with the application thanks to the glasses' accelerometers.

Eligibility criteria:
inclusion criteria: 1. gonarthrosis on a varum knee requiring a total knee replacement 2. female or male, 18 years of age or older 3. affiliation to a social security scheme 4. patient has been informed of the study and has signed an informed consent form exclusion criteria: 1. osteonecrosis, 2. post traumatic osteoarthritis with femoral or tibial callus, 3. history of tibial or femoral osteotomy, 4. valgum knee, 5. isolated patellofemoral osteoarthritis, 6. significant hip dysplasia or other excessive pelvic deformity, 7. patient already equipped with medical devices that may conflict with the instrumentation required for augmented reality navigation, 8. pregnant or breastfeeding women, 9. patients under legal protection.

Keywords: tkr: total knee replacement
sensory stimulation during cimt

Conditions: Cerebral Palsy

Summary: the long-term goal of this project is to assess the impact of the novel sensory stimulation technique in enhancing outcomes of constraint-induced movement therapy (cimt) in children with cerebral palsy. this is a pilot project.

the stimulation is peripheral sensory stimulation involving application of low-level, random-frequency vibration to the wrist skin. the hypothesis is that improvement in upper extremity function will be greater for the experimental group receiving the stimulation during cimt compared with the control group who will wear the device with no vibration (placebo). this pilot study is to assess feasibility and safety.

Eligibility criteria:
* between the ages of 3 and 9 * have unilateral upper limb motor weakness. * use the affected extremity as a gross assist during play and self-care activities. * no significant developmental delays that would limit spontaneous use of the more affected extremity. * be ambulatory for their age and demonstrate intact balance and protective reactions throughout the less involved upper extremity. * no other health impairment other than hemiparesis.

Keywords: pediatric hemiplegic hand function
an extension study of onartuzumab in participants with solid tumors on study treatment previously enrolled in a company sponsored study

Conditions: Solid Tumor

Summary: this extension study will provide continued onartuzumab and/or parent trial (p-trial) designated control treatments to participants with cancer who were previously enrolled in a company-sponsored onartuzumab p-trial and who derived benefit, as assessed by the responsible investigator, from the therapy administered in the p-trial. the study will also collect safety data with regard to administration of continued onartuzumab therapy.


Eligibility criteria:
inclusion criteria: * enrolled and receiving either control treatment or onartuzumab-based study treatment in an eligible p-trial * has not met the treatment discontinuation criteria specified in their p-trial protocol at the time of enrollment into the extension trial (e-trial) * ability to begin treatment in the extension (rollover) protocol within 15 days following the last day of the study in the antecedent protocol * for women who are not postmenopausal (greater than or equal to \[\>/=\] 12 months of non-therapy-induced amenorrhea) or surgically sterile (absence of ovaries and/or uterus): agreement to remain abstinent or use single or combined non-hormonal contraceptive methods that result in a failure rate of less than (\<) 1 percent (%) per year during the treatment period and for at least 180 days after the last dose of study drug * for men: agreement to remain abstinent or use a condom plus an additional contraceptive method that together result in a failure rate of \< 1% per year during the treatment period and for at least 180 days after the last dose of study drug and agreement to refrain from donating sperm during this same period exclusion criteria: * pregnancy or lactation or intention to become pregnant during the study (serum pregnancy test required before enrollment) * any non-protocol anti-cancer therapy started between discontinuation from treatment in p-trial and start of enrollment in e-trial.
assessment of treatment efficacy using smile arc marginal ridge approach versus mbt chart method for bracket positioning

Conditions: Class I Malocclusion

Summary: the goal of this randomized clinical trial is to evaluate the effect of smile arc marginal ridge approach (samra) versus mbt chart method for bracket positioning on orthodontic treatment results. the main questions it aims to answer are: is there a difference in orthodontic treatment results between smile arc marginal ridge approach (samra) and mbt chart method for bracket positioning? does samra provide more accurate orthodontic results and reduce the number of archwire bendings and brackets repositioning needed during finishing? the investigators will compare smile arc marginal ridge approach (samra) with mbt chart method (gold standard) to see if samra provides more accurate orthodontic results and reduce the need for archwire bendings and brackets repositioning during finishing. participants will: * undergo orthodontic treatment and divided into two groups, group a (samra) and group b (mbt chart method). * 0.018-inch mbt brackets will be used in both groups. * follow ups every 1 month will take place to change the archwires after becoming passive. * after leveling and alignment is completed, orthodontic treatment results, number of archwire bendings and brackets repositioning needed will be determined to see which type of intervention is better or if both provide similar results.


Eligibility criteria:
inclusion criteria: * orthodontic patients aged 11-30 years old. * mild or moderate crowding not requiring tooth extraction. * full permanent dentition including fully erupted 7s not necessarily 8s. * good oral hygiene. * skeletal and dentoalveolar class i malocclusion. exclusion criteria: * systemic disease potentially affecting the study outcome. * cleft lip and palate/syndromic patients. * any signs or symptoms of temporomandibular disorders (tmd). * previous orthodontic treatment. * pregnant females. * chronic use of medications.