Kornimate/medical-research-clean huggingface dataset:
therapies for salivary flux stimulation in patients transplanted with hematopoietic stem cells

Conditions: Mucositis

Summary: the transplantation of hematopoietic stem cells (thsc) is a therapeutic modality developed for the treatment of various diseases such as leukemia, bone marrow aplasia, lymphomas, multiple myeloma, among others. most patients who undergo the thsc usually have oral manifestations as a result of immunosuppression achieved by chemotherapy and/or radiotherapy. the most common complications are the reduction of salivary flow, mucositis and graft-versus-host disease (gvhd). these conditions can be very debilitating and interfere with medical therapy, leading to systemic complications, affecting the prognosis and increasing the length of hospitalization of the patient and the costs of treatment. to date, there is no protocol that prevents the reduction of salivary flow and minimizes the occurrence of mucositis and gvhd in these patients. this study aims to verify the effectiveness of treatment with two sialogogues (hyperboloid and tens \[transcutaneous electrical stimulation\]) to restore the flow and biochemical composition of saliva in patients undergoing thsc myeloablative and non-myeloablative conditionating regime.

it will be included in the sample a total of 60 patients undergoing hematopoietic stem cell transplantation (thsc) at the clinical hospital. patients will be randomly divided into four groups, each with 15 subjects: group i patients who will use only the mechanical sialogogue; group ii patients who will make use of electrical sialogogue (tens); group iii patients who will make use of mechanical sialogogue associated with tens and group iv patients who will not receive therapy (control). the project will present the following experimental design: 1. selection of patients to be subjected to the transplantation of hematopoietic stem cells; 2. implementation of a reference sialometry; 3. institution of therapy with mechanical and electrical sialogogue; 4. clinical examination, assessment of the occurrence of mucositis and obtention of saliva samples pre- and post-thsc; 5. qualitative analysis of saliva (turbidity, viscosity and color); 6. biochemical analysis of saliva; 7. statistical analysis of data.

Eligibility criteria:
inclusion criteria: * patients submitted to thsc at clinical hospital of federal university who underwent a myeloablative or a non-myeloablative conditioning regime * age over 16 years * oral mucosa intact on the first day of conditioning * ability to cooperate with treatment exclusion criteria: * cases with no clinical follow up * patients who refuse to participate * patients with no ability to cooperate with treatment

Keywords: salivary stimulation transplantation of hematopoietic stem cells hyperboloid transcutaneous electrical stimulation
a study to compare the pharmacokinetics (pk) of depemokimab when delivered with a safety syringe device (ssd) or an autoinjector in healthy adult participants

Conditions: Asthma

Summary: this study will compare the pharmacokinetics, safety, tolerability, and immunogenicity of depemokimab administered via a ssd or autoinjector in healthy participants.


Eligibility criteria:
inclusion criteria: * participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, clinical laboratory tests, vital sign measurements, and 12-lead electrocardiogram results. * body weight greater than or equal to (\>=) 50 kilograms (kg) (110 pounds-mass/ibs) and body mass index within the range 19 to 30 kg per meter square (inclusive). * women who have the potential to become pregnant must use a form of highly-effective contraception. * capable of giving signed informed consent. exclusion criteria: * history or presence of or current cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs, constituting a risk when taking the study intervention, or interfering with the interpretation of data. * participants with allergy/intolerance to a monoclonal antibody or biologic or participants with a previous history of clinically significant multiple or severe drug allergies/intolerance. * current evidence or recent history of an infective illness. * a positive pre-study drug/alcohol screen or a history (or suspected history) of alcohol misuse or substance abuse * clinically significant abnormalities. * positive test for severe acute respiratory syndrome coronavirus (sars-cov-2) at screening. * recent prior or concurrent clinical study experience.

Keywords: autoinjector depemokimab healthy participants safety syringe device pharmacokinetics
three different modalities for treatment of inflammatory punctal stenosis

Conditions: Modalities; Treatment; Inflammatory Punctal Stenosis

Summary: this study aimed to compare the efficacy of three various modalities of treatment of inflammatory punctal stenosis (punctal dilatation alone, combined punctal dilatation with topical medications, or peri-punctal injection of triamcinolone acetonide)

acquired punctal stenosis is a condition in which the external opening of the lacrimal canaliculus, located in the nasal part of the palpebral margin, is narrowed or occluded. this condition results from chronic inflammation of the external punctum, leading to gradual fibrotic changes in the ostium, followed by progressive occlusion of the duct. different modalities were described for the treatment of acquired punctual stenosis. repeated dilatation of the stenotic punctum is a simple procedure that may provide temporary improvement of the symptoms, but restenosis is common unless additional procedures are performed. many other methods were used to augment punctual size, including 1-snip, 2-snip, and 3-snip punctoplasty, supplemented with adding sutures or mini-monoka insertion and punch punctoplasty.

Eligibility criteria:
inclusion criteria: * age from 33 to 75. * both sexes. * patients with inflammatory punctal stenosis or occlusion complaining of symptomatic epiphora. exclusion criteria: * subjects with previous lacrimal surgeries. * subjects with lid margin malposition such as ectropion, entropion, or lid retraction. * subjects with medial lid masses obscuring the punctum. * subjects with a history of ocular trauma involving the medial aspect of the lid margin.
prevention of alopecia in patients with localised breast cancer

Conditions: Chemotherapy-induced Alopecia

Summary: the prevention of chemotherapy-induced alopecia (cia) is still imperfectly managed in france. strengthening the evidence base on the benefits of strategies to prevent cia, based on robust methodologies, remains a prerequisite for better integration of appropriate supportive care for patients receiving chemotherapy. this research should provide new knowledge on the benefits of scalp refrigeration during anthracycline- and taxane-based chemotherapy in preventing aci, for each of the 2 refrigeration techniques. in addition to effectiveness in preventing aci, quality of life, self-image and satisfaction with care will be assessed by patients during and after chemotherapy. the medico-economic aspects will also be assessed for each of the two refrigeration modalities. the results of the various proposed assessments will be used to guide the choice between these two techniques for preventing aci.


Eligibility criteria:
inclusion criteria: * age \>18 * female * histologically proven diagnosis of localised, non-metastatic breast cancer * indication for neo-adjuvant or adjuvant anthracycline and taxane chemotherapy (3 ec100 followed by 3 docetaxel or 3 ec100 plus 12 paclitaxel); her-positive status is not a non-inclusion criterion. * patient willing to be photographed to assess ifa * fluency in french * patient affiliated to a social security scheme * signature of informed consent exclusion criteria: * history of neck pain * pre-existing alopecia * participation in another trial * dermatosis of the scalp * contraindication to scalp cooling * history of migraines, stroke or hyperthyroidism * history of scalp metastases * sensitivity to cold, cold agglutinin disease, cryoglobulinaemia, cryofibrinogenaemia or post-traumatic cold dystrophy. * malignant haemopathies * history of chemotherapy treatment * indication for cerebral irradiation * pregnant or breast-feeding patient * raynaud's syndrome

Keywords: alopecia chemotherapy-induced
cold polypectomy site study

Conditions: Colonic Polyps

Summary: removal of polyps at colonoscopy reduces colon cancer. snare polypectomy is the conventional method for removal however the snared area after removal can occasionally appear uneven raising the possibility that complete removal has not occurred. the significance of this irregularity has not be studied. this study aims to separately sample the irregular area and determine the constituents while recording how frequently this occurs during routine colonoscopy and polypectomy. we hypothesize that the irregular areas are submucosal tissue and do not represent polyp tissue left behind.


Eligibility criteria:
inclusion criteria: * patients undergoing colonoscopy with at least one polyp identified where polypectomy is planned. exclusion criteria: * age \< 18 years * patients where polypectomy is not planned to be undertaken (patients scheduled for diagnostic colonoscopy only).

Keywords: polyp colon polypectomy snare
combivir and maraviroc in antiretroviral naive subjects in russia

Conditions: HIV

Summary: one hundred subjects in russia will be treated with a combination of combivir (zidovudine and lamivudine) and maraviroc as their first line hiv therapy. the aim is to assess the efficacy and safety of this combination in a russian population of patients.


Eligibility criteria:
inclusion criteria: * over 18 years of age. * r5 hiv infection on screening tropism test. * viral load \>1,000 copies/ml. * never previously treated with anti-hiv medicines. exclusion criteria: * previously treated with anti-hiv medicines. * hepatitis b co-infection.

Keywords: maraviroc naive hiv zidovudine lamivudine combivir clade a
dynamic ventilatory and asymmetry of the chest wall during breath stacking and volume-oriented incentive spirometer

Conditions: Stroke

Summary: the purpose of the study was to analyze the effect of is and bs on dynamics ventilatory and asymmetry of the chest wall in patients after stroke .

all volunteers were undergone to two types of pulmonary expansion therapy (pet) techniques: volume incentive spirometry (vis) and bs. procedures involved two distinct phases: assessment and intervention. in the first day was performed assessment of the participants to obtain the following data: anamnesis, initial evaluation using the ashwouth scale, barthel index and mini mental state examination, anthropometric data and pulmonary function using spirometry and respiratory muscle pressures. intervention phase was performed in two different days, each day for only one pet techniques (vis or bs), with a minimal wash-out period of one day according to the randomization sequence. optoelectronic pletysmography (oep) was recorded during quite breathing at rest and during the execution of five maneuvers form each pet technique tested.

Eligibility criteria:
inclusion criteria:subjects with right hemiparesis due to stroke for more than three months, of both genders, most than 20 years, with scores between 1 and 3 for ashworth scale for upper limb, up to 85 for index score barthel and minimum score of 18 on the mini mental state examination. - exclusion criteria: facial paralysis, rheumatic or orthopedic diseases or deformities / abnormalities in the spine that could compromise the respiratory mechanics; reported respiratory conditions (asthma, chronic obstructive pulmonary disease, cystic fibrosis) or presenting spirometry with forced expiratory volume in one second (fev1) below 80% predicted and compared vef1/capacitate forced vital ≤ .7; history of recent abdominal or thoracic surgery and hemodynamic instability or pregnancy. -

Keywords: stroke incentive spirometry breath stacking optoelectronic plethysmography
clevidipine in the postoperative treatment of hypertension (eclipse-nic)

Conditions: Hypertension

Summary: the purpose of this study is to establish the safety of clevidipine in the treatment of postoperative hypertension. approximately 250-500 patients with postoperative hypertension after undergoing coronary artery bypass grafting (cabg), off-pump coronary artery bypass (opcab) or minimally invasive direct coronary artery bypass (midcab) surgery and/or valve replacement/repair procedures were anticipated to be randomly assigned to one of two treatment groups: clevidipine or nicardipine.

the primary objective was to establish the safety of clevidipine in the treatment of postoperative hypertension, as assessed by comparing the incidences of death, stroke, mi and renal dysfunction in the clevidipine and nicardipine treatment groups from the initiation of study drug infusion through postoperative day 30. secondary objectives were to evaluate the efficacy of study drug, assessed by the blood pressure (bp) lowering effect, and additional safety variables.

Eligibility criteria:
prerandomization inclusion criteria: * provide written informed consent before initiation of any study related procedures. * be at least 18 years of age * be scheduled for coronary artery bypass grafting (cabg), off pump coronary artery bypass (opcab), minimally invasive direct coronary artery bypass (midcab) surgery, and/or valve replacement/repair surgery prerandomization exclusion criteria: * women of child-bearing potential (unless they have a negative pregnancy test) * recent cerebrovascular accident (within 3 months before randomization) * known intolerance to calcium channel blockers * known or suspected hypersensitivity to nicardipine * allergy to soybean oil or egg lecithin (components of the lipid vehicle) * pre-existing permanent ventricular pacing * any other disease or condition, which, in the judgment of the investigator would place a patient at undue risk by being enrolled in the trial * participation in another therapeutic drug or therapeutic device trial within 30 days of starting study postrandomization inclusion criteria: * expected to survive beyond 24 hours post-surgical procedure * no surgical complications or conditions, present or anticipated, that preclude them from inclusion in the study * determined to be hypertensive postoperatively as determined by the investigator

Keywords: postoperative hypertension
efficacy of exercise for sexual side effects of antidepressants

Conditions: Sexual Dysfunction

Summary: the major aim of the this study is to replicate findings of previous research that examined the effects of acute exercise on sexual arousal in women in a novel population, namely, women taking antidepressants of the selective serotonin reuptake inhibitors (ssri) or selective serotonin and norepinephrine reuptake inhibitors (snri) class. in previous studies it has been found that acute, moderate-intensity exercise facilitated physiological sexual arousal responses in healthy, sexually functional women. however, it is known that antidepressants may induce sexual dysfunction, and thus in the present study, the investigators are examining whether acute exercise may facilitate sexual responses in women with taking antidepressants, including women with antidepressant-related sexual dysfunction.


Eligibility criteria:
inclusion criteria: * female * age 18 or older * currently receiving a consistent dosage of escitalopram, citalopram, sertraline, desvenlafaxine, venlafaxine, or duloxetine * currently sexually active * willing and able to exercise * experiencing regular menstrual cycles * not currently pregnant and not intending to become pregnant during trial exclusion criteria: * currently taking more than one psychoactive medication * factors indicating risk of cardiovascular activity, including acute or chronic cardiovascular illness, including clinically significant hypertension (defined as self-reported hypertension or "blood pressure greater than 140/90" or receiving medications designed to treat hypertension); recent chest pain; frequent or recurrent faint or dizzy spells; severe or untreated exercise-related asthma; or musculoskeletal illness or injury that would be expected to worsen with physical exercise. additionally, women will be excluded if they are found to have any of the following as measured during the fitness assessment of the first session: a bmi over 40, waist circumference over 40 inches, waist-to-hip ratio of greater than 0.9, systolic blood pressure greater than 150 or diastolic pressure over 95, or resting heart rate over 90. * factors associated with significant genital nerve damage, including: previous major pelvic surgery that may have caused nerve damage, including hysterectomy, vulvectomy, circumcision, colostomy, cystostomy, or serious bladder, rectal, or abdominal surgery; or neurological impairment due to diabetes, stroke, pelvic nerve damage secondary to trauma, cancer treatments, myasthenia gravis, multiple sclerosis or spinal cord damage. * factors associated with non-normative endocrine function, including: perimenopausal or menopausal status, or \>1 missed menstrual period in the previous 6 months; or currently pregnant, breastfeeding, or having breastfed within the past 3 months; or reporting clinically significant untreated renal or endocrine disease * untreated serious mental health conditions * sexual aversion or distress due to history of unwanted sexual contact

Keywords: physiological antidepressive agents
effect of aerobics and balancing exercises on anxiety and dizziness in patients with covid-19

Conditions: Corona Virus Infection

Summary: the recently emerged coronavirus named severe acute respiratory syndrome coronavirus 2 (sarscov-2) is the newest threat to human health. it has already infected more than half a million people worldwide, leading to a lot of deaths. patients with coronavirus disease 2019(covid-19) will experience high levels of anxiety and low sleep quality due to isolation treatment. purposes: was to investigate the effect of aerobics and balancing exercises on anxiety and dizziness in patients with covid-19. subjects: thirty anxiety and dizziness patients with covid-19 aged from 45-65 years of both sexes, randomly divided into two groups, selected from outpatient clinic ,general

in december 2019, a series of pneumonia cases of unknown cause emerged in wuhan, hubei, china, with clinical presentations greatly resembling viral pneumonia. deep sequencing analysis from lower respiratory tract samples indicated a novel coronavirus, which was named 2019 novel coronavirus disease (covid-19). on february 12, 2020, who officially named the disease caused by the novel coronavirus as coronavirus disease 2019 (covid-19),and by march 11th, 2020 when the number of countries involved was 114, with more than 118,000 cases and over 4000 deaths, the who declared the pandemic status

Eligibility criteria:
inclusion criteria: * thirty patients with covid-19 * age between 45 -65 years * cooperative patient. * all patients were referred from physician with the diagnosis of covid-19 exclusion criteria: * overweigh patients with body mass index more than 30. * pregnant women. * cancer patients. * smokers * patients with chronic heart disease

Keywords: aerobics - balance exercises -anxiety - dizziness disorder
prophylactic tranexamic acid to reduce blood loss during caesarean delivery.

Conditions: Post Partum Hemorrhage

Summary: postpartum hemorrhage continues to be the leading cause of maternal morbidity and mortality. globally, it is responsible for 25% of all pregnancy-related deaths. pph is unpredictable and may occur in the absence of risk factors. tranexamic acid is an antifibrinolytic proven to reduce blood loss and transfusion requirements for various surgeries. this study aims to explore the effectiveness of tranexamic acid as an adjunct to other uterotonics before the caesarian section.


Eligibility criteria:
inclusion criteria: 1. the women undergoing cesarean delivery (both elective and emergency) during the study period. 2. willing to participate in the study after understanding the concept. exclusion criteria: 1. critically ill patient. 2. not willing to give consent to participate in the study 3. cases diagnosed with a ruptured uterus or undergoing caesarian hysterectomy during operation.
cho-loading before and high intermittent cho-intake during physical exercise in t1d

Conditions: Diabetes Mellitus, Type 1

Summary: prolonged physical exercise (pe) is a challenge in type 1 diabetes with an increased incidence of both hypoglycemia and hyperglycemia. the purpose was to evaluate the impact of two consecutive days of carbohydrate (cho) loading, followed by high intermittent cho-intake during prolonged pe, facilitated by a proactive use of real-time continuous glucose monitoring (rtcgm), on glucose control in individuals with type 1 diabetes. ten physically active individuals with type 1 diabetes were invited to participate in a 3-day long sports camp with the objective to evaluate cho-loading and high intermittent cho-intake during prolonged pe. 1.5 months later the same procedure was evaluated during a 90 km cross-country skiing race. participants were instructed to act proactively using rtcgm with predictive alerts set for high and low glucose values to maintain sensor glucose values within target range, defined as 72-180 mg/dl (4-10 mmol/l).

this is a descriptive, single arm, non-randomized interventional study. the intervention consisted of carbohydrate loading prior to and intermittent high carbohydrate intake during physical exercise and a proactive use of real-time continuous glucose monitoring (rtcgm) to achieve and maintain glucose control. central contact person stig a mattsson, dietician phd student phone: +46702047759 e-mail: stigmattsson@live.com ipd sharing statement no: there is not a plan to make ipd available.

Eligibility criteria:
inclusion criteria: * age 18-50 years * type 1 diabetes * diabetes duration \>1 year * exercising regularly ≥3 workout/week * previous experience from cross-country skiing exclusion criteria: * a1c 8.6% ngsp (70 mmol/mol ifcc) * proliferative retinopathy * known nephropathy * cardiac failure * following a low-carbohydrate diet.