Kornimate/medical-research-clean huggingface dataset:
biaxial microincision cataract surgery technique

Conditions: Cataract Senile

Summary: to analyze and compare visual results, keratometry, sia and hoas outcomes of biaxial microincision cataract surgery in elderly population, including diabetic and non-diabetic patients.

modern trends in cataract surgery is the bimanual mics technique. mics significant development for 15 years gives possibility to implant the intraocular lens by 1.4mm incision. this is not only a change in surgery technique, but it is a significant progress in safety and quality post-operative results. bimanual cataract mics technique gives the opportunity to reduce width of the corneal incision more than 40% comparing to the standard coaxial cataract surgery by use dedicated mics iol's. this allows to perform less traumatic surgery and provides the opportunity for fast visual rehabilitation from the first week after cataract surgery. the possibility of using multifocal and toric intraocular lenses in mics technique fully meet the requirements of modern refractive intraocular surgery.

Eligibility criteria:
inclusion criteria: 1.clinical diagnose of senile cataract. exclusion criteria: 1. eye trauma in anamnesis. 2. eye surgery in anamnesis. 3. corneal surgery in anamnesis. 4. corneal irregular astigmatism. 5. corneal ectasia.

Keywords: bimics, biaxial cataract surgery, sia,diabetes mellitus,
vaginal bromocriptine for treatment of adenomyosis

Conditions: Adenomyosis

Summary: adenomyosis is a rare non-malignant disease of the uterus that causes significant symptoms including heavy menstrual bleeding and pelvic pain. the only widely accepted treatment for adenomyosis is hysterectomy. the investigators will use a dopamine agonist, bromocriptine, as a therapy based on animal models of the disease and our prior clinical research to observe any objective improvement in the extent of the disease using magnetic resonance imaging (mri)and standard measurements for other gynecologic diseases to measure symptomatology.

women with adenomyosis proven with mri will be considered for the intervention with bromocriptine. they will be reassessed at 1, 6 and 9 months. patients will get a stipend for each visit they complete. the study will end for the enrolled subject at 9th month follow-up

Eligibility criteria:
inclusion criteria: 1. women able to give informed consent and willing and able to attend all study visits 2. premenopausal women at least 25 years of age 3. no evidence of high grade sil by pap smears or hpv testing within institutional guidelines 4. mri or ultrasound imaging consistent or highly suggestive of adenomyosis 5. use of barrier contraception, sterilization or sexual abstinence exclusion criteria: 1. women actively trying for pregnancy, currently pregnant, less than six months postpartum or breastfeeding 2. uterine size \> 20 weeks 3. active pelvic infection or current use of intrauterine contraceptive device 4. current use of gnrh agonists or antagonists, or contraceptive steroids 5. mri suggestive of malignant disease of uterus, ovary, or cervix 6. hypersensitivity to bromocriptine or ergot alkaloids 7. history of gastrointestinal ulcers 8. history of syncope, syncopal migraine or seizure 9. uncontrolled hypertension 10. history of myocardial infarction, uncontrolled hypertension, heart valve disorder or cerebrovascular accident 11. history of diabetes mellitus except gestational diabetes 12. history of parkinson's disease 13. history of psychosis 14. history of pleural or pericardial effusion 15. history of pulmonary fibrosis or thickening of the pleura 16. history of lactose intolerance 17. history of reynaud's disease 18. use of opioid pain medications

Keywords: adenomyosis dysmenorrhea abnormal uterine bleeding heavy menstrual bleeding menorrhagia
covidar - arrhythmias in covid-19

Conditions: COVID; Arrhythmia; Torsades de Pointe Caused by Drug; Qt Interval, Variation in; Atrioventricular Block; Atrial Fibrillation; Bradyarrhythmia; Ventricular Arrythmia

Summary: background and rationale: there is very limited literature available on the arrhythmia occurrence in the context of an infection by the sars-cov2 virus. on the other hand, treatment strategies against the sars-cov2 virus may carry a risk of qtc prolongation and pro-arrhythmia/sudden death which may be amplified by concomitant use of other qtc-prolonging drugs and/or ion disbalances. covidar is an international initiative to monitor the occurrence of arrhythmic events in the context of the sars-cov2 infection, to identify potential modifiable predisposing factors to reduce their incidence and to inform the best arrhythmia management options in this patient population. main objective: to describe the incidence and type of arrhythmic events in the context of the sars-cov2 infection. study design: patient registry (observational). patients will not undergo any additional investigations. only data that is generated during routine clinical care will be collected. study population: patients admitted to the hospital highly suspected of or with confirmed covid-19.

the covidar registry is an international longitudinal multicentre observational study worldwide which aims to assess the incidence, type and risk factors of arrhythmias in the context of sars-cov2 infection, also providing relevant information on events/management and major cardiovascular outcomes. during the course of the registry patients will be followed up according to the usual practice of the centres. drug prescriptions and indications to perform diagnostic/therapeutic procedures will be completely left to the treating physicians. the registry population will consist of patients presenting with a suspicion of sars-cov2 infection, who are hospitalised in a medical or surgical department of the participating hospitals. patients will officially be enrolled in the covidar registry if the covid-19 disease has formally been noted or confirmed in the patient's medical record. the registry will include all patients and collect data at the following timepoints: * admission: evaluation before sars-cov2 infection treatment initiation * on-treatment: evaluation 24-28h after treatment initiation * at any adverse event: evaluation if any adverse event occurs * at discharge: evaluation of clinical status at the end of the admission period.

Eligibility criteria:
inclusion criteria: * patients admitted with highly suspected/confirmed infection with sars-cov-2. exclusion criteria: * formal opposition by the patient to data collection.
a study of n9 chemotherapy in children with neuroblastoma

Conditions: Neuroblastoma; Pediatric Cancer

Summary: the purpose of the study is to find out whether n9 is a safe and effective treatment for children with neuroblastoma. n9 includes 3 different combinations of chemotherapy drugs that are given at different times - cyclophosphamide, topotecan, and vincristine (ctv), ifosfamide, carboplatin, and etoposide (ice), cyclophosphamide, doxorubicin, and vincristine (cdv).


Eligibility criteria:
inclusion criteria: * diagnosis of nb as defined by histopathology (confirmed by the msk department of pathology), bm metastases plus high urine catecholamine levels, or positivity in mibg scan. * hr-nb, defined as mycn-amplified stage 2/3/4/4s at any age and stage 4 in patients \>18 months old. * no more than one prior cycle of chemotherapy. * age \<19 years old. * signed informed consent indicating awareness of the investigational nature of this treatment. exclusion criteria: * severe dysfunction of major organs, i.e., renal, cardiac, hepatic, neurologic, pulmonary, hematologic, or gastrointestinal toxicity ≥ grade 3. * inability to comply with protocol requirements. * pregnancy is not an issue because all patients will be pre-adolescents.

Keywords: hr-nb neuroblastoma pediatric cancer 21-228 memorial sloan cancer center
coronavirus response - active support for hospitalised covid-19 patients

Conditions: Covid-19

Summary: the crash-19 trial is a multinational, open-label, factorial, randomised trial in adults hospitalised with suspected or confirmed acute covid-19 infection.

we will evaluate the effect of aspirin (150mg once daily), losartan (100mg once daily), and simvastatin (80mg once daily) in patients with covid-19 infection. eligible patients will be randomly allocated to one of eight study arms (aspirin only; losartan only; simvastatin only; aspirin and losartan; aspirin and simvastatin; losartan and simvastatin; aspirin, losartan and simvastatin; standard care only). trial treatments are given in addition to the usual standard of care at the study hospital. treatment will be started as soon as possible after randomisation and will continue until death, discharge or 28 days after randomisation, whichever occurs first.

Eligibility criteria:
inclusion criteria: * adults age 40 years and older * with suspected or confirmed acute covid-19 infection. acute covid-19 infection is suspected in the presence of a fever and at least one symptom of respiratory disease e.g. cough, difficulty breathing, signs of hypoxia. the clinician may suspect covid-19 infection if i) the patient lives in or has recently travelled to an area with covid-19 transmission; ii) the patient had recent contact with a confirmed or probable covid-19 case, or iii) no alternative diagnosis fully explains the clinical presentation * requiring hospitalisation exclusion criteria: * women known to be pregnant * patients hospitalised without symptoms of acute covid-19 infection should not be recruited even if they test positive for covid-19 * patients already receiving mechanical ventilation * patients with a definite indication or contraindication for any of the trial treatments. * patients who are very severely frail (completely dependent and approaching end of life who typically they could not recover even from a mild illness) or terminally ill should not be recruited.

Keywords: adult respiratory distress syndrome pneumonia myocardial infarction
wound infiltration with ketorolac versus lidocaine for postoperative analgesia after total abdominal hysterectomy

Conditions: Anesthesia

Summary: the main goal of this study is to compare wound infiltration with ketorolac versus lidocaine for postoperative analgesia in total abdominal hystrectomy (tah) operation.


Eligibility criteria:
inclusion criteria: * asa physical status i and ii * planned for elective tah with a pfannenstiel incision exclusion criteria: patients with the following criteria will be excluded from the study; * asa physical status more than ii * body mass index (bmi)\>35 kg/m2 * previous abdominal surgeries * malignancy * individuals with chronic pain * a history of severe systemic disease * a pre-existing neurological or psychiatric illness * known to be addict on alcohol or drugs * known allergy to the study drugs
atazanavir versus lopinavir/ritonavir (lpv/rtv) in patients who have not had success with protease inhibitor-containing haart regimen(s)

Conditions: HIV Infections

Summary: this study will compare 2 treatments in the way they affect cholesterol levels and the amount of hiv in the blood.

the study is designed to determine the metabolic changes, antiviral activity, safety, and tolerability of atazanavir as compared to lpv/rtv, each in combination with 2 nucleosides, over the initial 24 weeks, with a final analysis at 48 weeks.

Eligibility criteria:
inclusion criteria patients may be eligible for this study if they: * are receiving a pi-containing highly active antiretroviral therapy (haart) for at least 12 weeks. * have a viral load of 1,000 or more copies/ml within 4 weeks of screening and within 4 weeks prior to randomization. * have 2 cd4 cell counts of 50 or more cells/mm3 at least 96 hours apart and within 4 weeks before randomization. * are at least 16 years old. * have a documented virologic response to at least 1 haart regimen. * have phenotypic sensitivity to at least 2 of the following: ddl, d4t, zdv, 3tc, abc. * have phenotypic sensitivity to atazanavir and lpv/rtv. * use effective barrier methods of birth control. * will be available for 48 weeks. exclusion criteria patients will not be eligible for this study if they: * have taken 2 or more pis and had virologic failure. * have taken atazanavir or lpv/rtv. * have an hiv-related infection (within 30 days) or any medical condition requiring treatment at the time of enrollment. * have had acute hepatitis in the 30 days prior to study entry. * have received certain drugs within 3 months of study start or expect to need them at time of enrollment. * abuse alcohol or drugs in a way that would interfere with the study. * have very bad diarrhea within 30 days prior to study entry. * are pregnant or breast-feeding. * have a history of hemophilia. * use lipid-lowering drugs (within the previous 30 days). * have cardiomyopathy or symptoms of other heart disease. * cannot take medicine by mouth. * have any other condition that would interfere with the study. * have pancreatitis, if choosing ddi as part of nrti pair. * have bilateral peripheral neuropathy at time of screening, if choosing ddi or or d4t as part of the nrti pair.

Keywords: hiv protease inhibitors rna, viral reverse transcriptase inhibitors anti-hiv agents viral load lipids abt 378 antiretroviral therapy, highly active lipoproteins, ldl cholesterol
cervical pessary in women with arrested preterm labor and short cervix

Conditions: Preterm Birth

Summary: preterm birth (ptb), defined as birth between 20 and 36 6/7 weeks, is responsible for the majority of the neonatal morbidity and mortality in the united states, and 35% of all u.s. healthcare spending on infants. globally, about 28% of the 4 million annual neonatal deaths are directly attributable to ptb. preterm labor (ptl) is the final pathway for about 50% of all ptb. tocolytic agents are drugs that can slow or stop labor contractions in the attempt to delay births preceded by ptl. primary tocolysis is defined as tocolysis given on initial presentation of women with ptl. in most of these women, ptl stops, but as their risk of ptb remains high, some have advocated use of maintenance tocolysis, i.e. tocolysis after arrested ptl. so far, no maintenance tocolytic agent has been shown to be beneficial in preventing ptb. the aim of this study is to evaluate the efficacy of maintenance tocolysis with arabin pessary compared to standard care in singleton gestations with arrested ptl and with short transvaginal ultrasound (tvu) cervical length (cl) \<25mm


Eligibility criteria:
inclusion criteria: * 18-50 ages * singleton pregnancy * 24(0) - 34(6) weeks of gestation * arrested preterm labor after primary tocolysis * transvaginal ultrasound cervical length less than 25mm at admission * agreement to regular follow-up and provision of written informed consent exclusion criteria: * pessary and no cerclage in situ * vaginal bleeding * placeta previa/accreta * multiple gestations * \ 24(6) weeks of gestation * cervical dilatation greater than 3 cm * chorioamnionitis * major fetal abnormalities * abruptio placentae * pprom * polyhydramnios or oligohydramnios * iugr/fgr with or without doppler abnormalities * preeclampsia or pregnancy-related hypertension
celebrex vs tramadol in the treatment of chronic lower back pain.

Conditions: Back Pain

Summary: this study investigates if celebrex is as effective as tramadol hydrochloride (ultram) for patients with chronic low back pain, when administered over a 6-week period.


Eligibility criteria:
inclusion criteria: * the subject presents with duration of chronic low back pain of \> 3 months requiring regular use of analgesics (\> 4 days/week), except for acetaminophen which cannot have been the sole analgesic used. exclusion criteria: * the subject has chronic low back pain, which is neurologic in etiology (i.e., radiculopathy, neuropathy, myelopathy)
community acquired pneumonia in telemark and ostfold

Conditions: Community Acquired Pneumonia

Summary: the aim of the study is to investigate the bacterial causes in community acquired pneumonia in adults admitted to hospital in two counties in norway and to look at possible factors that makes the patients susceptible to pneumonia.

in norway there is little knowledge of which bacterias that causes pneumonia in patients admitted to hospital. there are also few registered cases of legionnaires disease every year, compared to our neighbour countries. therefore 500 patients with community acquired pneumonia admitted to telemark hospital and ostfold hospital in norway will be tested by urin antigen test for the detection of legionella pneumophila serogroup 1 and streptococcus pneumoniae. we will also perform routine bacterial culture of sputum and culture on medium for isolation of legionella species. a throat swab from the patients will be tested for mycoplasma pneumoniae, chlamydophila pneumoniae and bordetella pertussis using pcr-techniques. legionella-serology will also be performed. in addition all the included patients are invited to fill in a questionnaire in order to look for risk factors for developing community acquired pneumonia.

Eligibility criteria:
inclusion criteria: * symptoms of lower airway infection and radiologic sings of pneumonia. exclusion criteria: * age\<18 * serious psychiatric illness * mentally retarded * hospitalized last 14 days

Keywords: pneumonia legionnaires disease risk factors
effects of progressive muscle relaxation exercises during pregnancy

Conditions: Restless Legs Syndrome

Summary: participants were allocated into three groups; the control group, progressive muscle relaxation (pmr) group and relaxation music (rm) group. the pmr and rm programs were explained toall participants, and the first program was tested under the supervision of the researcher. pmr and rm group participants performed the program daily throughout 4 weeks. severity of rls with the international restless leg syndrome scale (irlss) and sleep quality with the pittsburgh sleep quality index (psqi) were assessed at baseline, 2 and 4 weeks for all the groups.

a cd recorded by the turkish psychological association was provided to explain relaxation techniques to pmr group participants. the cd contains relaxation exercises instructions and there is relaxing music in the background. this cd consists of two parts. the first part(11 minutes) gives short information about the content and how exercises should be done. it consists of information about deep relaxation. in the second part, there are 27 minutes of relaxation exercises accompanied by command with background music. pmr exercise consists of four stages: stretching-relaxation (1st stage -approximately 20 minutes), autogenic training - only relaxation (2nd stage approximately 10 minutes), deep breathing training-breathing relaxation (3rd stage approximately 3-4 minutes), rapid relaxation (4th stage--a few seconds). in the first stage, the participant was instructed to first stretch and then relax the specified muscle group (hand, forearm, upper arm, forehead, cheek, nose, chin, neck, chest, shoulder, waist, abdomen, stomach, hip, calf, foot) in sequence. the participant was asked to constantly compare the feeling of tension that shehas just experienced with the feeling of relaxation later. another cd recorded by the turkish psychological association was provided to rm group participants. it consists of 30 minutes relaxing music only.the participant was asked to just listen to music with without working in a private room.

Eligibility criteria:
inclusion criteria: 1. diagnosed with rls by a physician 2. 27 to 34 weeks gestation 3. aged 20 to 35 years 4. able to understand and answer questions in the scale and forms 5. having a cd player exclusion criteria: * have 1. vision-hearing problems 2. chronic disease (hypertension, diabetes mellitus, heart disease, etc.) 3. any psychiatric diagnosis 4. multiple pregnancy 5. rheumatic disease (to avoid difficulties in assessing the severity of rls) 6. lumbar hernia and low back pain complaints (to avoid difficulties in assessing the severity of rls) 7. varicose veins in the legs (to avoid difficulties in assessing the severity of rls)

Keywords: progressive relaxation exercises sleep quality relaxation music pregnancy
study of prophylactic effect of rivaroxaban on venous thromboembolism in aecopd

Conditions: Acute Exacerbation Copd; Venous Thromboembolism

Summary: aecopd increases the risk of vte.vte prevention is a long way to go for high-risk vte patients in china.the incidence of aecopd complicated with vte in asian population is high and the mortality rate is high.rivaroxaban, a new oral anticoagulant, has been widely used in the treatment and prevention of vte.however the question about the efficacy and safety of new oral anticoagulant compared with lmwhs for the prevention of symptomatic vte and vte-related death post-hospital discharge in high-risk aecopd patients is still unknown. thus this study is to evaluate if the prophylactic anticoagulation effect by rivaroxaban is non-inferiority than enoxaprine in high risk aecopd and to evaluate the safety of using rivaroxaban to prevent vte in high risk aecopd comparing with enoxaprine.

the acute exacerbation of copd increases the risk of venous thromboembolism.vte prevention is a long way to go for high-risk vte patients in china.the incidence of aecopd complicated with vte in asian population is high and the mortality rate is high.rivaroxaban, a new oral anticoagulant, has been widely used in the treatment and prevention of vte.however the question about the efficacy and safety of new oral anticoagulant compared with lmwhs for the prevention of symptomatic vte and vte-related death post-hospital discharge in high-risk aecopd patients is still unknown. thus this study is to evaluate if the prophylactic anticoagulation effect by rivaroxaban is non-inferiority than enoxaprine in high risk aecopd and to evaluate the safety of using rivaroxaban to prevent vte in high risk aecopd comparing with enoxaprine.

Eligibility criteria:
inclusion criteria: * aecopd patients meeting the eligibility criterion by gold2017 in hospitalization；padua score \> 4；age from 40-80y exclusion criteria: * patients whose admitting diagnosis was vte；patients whose duration of hospital stay was \ 30 days ；patients who received therapeutic doses of anticoagulants or thrombolytic therapy for any indication before hospitalization；an organic lesion that could bleed; severe liver or renal failure; confirmed or uncontrolled hypertension; a congenital or acquired coagulation disorder; a history of hypersensitivity or thrombocytopenia to heparins of any type；patients who were contraindicated to anticoagulant therapy, venography, or angiography

Keywords: aecopd vte prevention rivaroxaban lmwhs