Kornimate/medical-research-clean huggingface dataset:
study of safety and potential efficacy of syn117 in cocaine dependent volunteers

Conditions: Cocaine Dependence

Summary: this study will assess the potential interaction and subjective effects between intravenous cocaine and syn117 in non-treatment seeking cocaine dependant subjects


Eligibility criteria:
inclusion criteria: * non treatment seeking cocaine dependent * english speaking * meet dsm iv tr criteria for cocaine dependence * pulse 50-90bpm * systolic bp 85-140 mmhg * diastolic bp 45-90 mmhg * essentially normal liver and kidney function blood tests * ecg normal * sign informed consent * negative urine pregnancy test at screening and admission exclusion criteria: * history or evidence of seizure disorder or brain injury * previous medically adverse reaction to cocaine, including loss of consciousness, chest pain or epileptic seizure * neurological disorders, organic brain disease, dementia * psychiatric disorders such as psychosis, schizophrenia, bipolar disorder, major depression * history of suicide attempts within past 3 months or suicidal ideation/plan * history of clinically significant heart disease or hypertension * family history in 1st degree relatives of early cardiovascular morbidity or mortality * untreated or unstable medical conditions * positive hiv test * pregnant or nursing * have asthma or are currently using alpha, beta agonists or theophylline or other sympathomimetics * test positive for other drugs of abuse with the exception of cocaine, cocaine metabolites or marijuana * any other illness, condition or use of psychotropic medications which preclude safe/successful completion of the study * currently on parole
effect of aging & obesity with exercise intervention

Conditions: Obesity

Summary: obesity leads to a vicious circle that increases intramuscular fat, insulin resistance, promotes muscular dysfunction resulting in increased muscle fat accumulation. the study of muscle function and intramyocellular lipids is insufficient for obesity. particularly, the study of mechanisms in muscle function and intramyocellular lipids is few nationally and internationally.

this study is prospective study. the goal of this study is 1. to examine the distribution and contractile properties (cross-sectional area, maximal force, specific force, maximal shortening velocity) of single muscle fiber sex/myosin heavy chain (mhc) type-related differences, by extracting a single muscle fiber from the vastus lateralis in young men and women. 2. to examine the effects of intramyocellular lipids on physical activity ability, muscle dysfunction, and metabolic disorders in relation to aging and obesity. 3. to examine the effects of intramyocellular lipids on physical activity ability, muscular dysfunction, and metabolic disorders after 12 weeks resistance exercise intervention.

Eligibility criteria:
inclusion criteria: * young men: age (20-35 yrs), bmi (19-23 kg/m2) * young women: age (20-35 yrs), bmi (19-23 kg/m2) * elderly women: age (65-80 yrs), bmi (19-23 kg/m2) * elderly obese women: age (65-80 yrs), bmi ( \>25 kg/m2) * subjects who can agree voluntarily. exclusion criteria: * acute coronary syndrome. * uncontrolled hypertension. * subjects who took drugs which can affects neuromuscular system. * severely impaired cognition * subjects who cannot agree voluntarily

Keywords: aging obesity single muscle fiber contractile properties intramyocellular lipids resistance exercise
use of fluticasone propionate/salmeterol combination post emergency department visit

Conditions: Asthma

Summary: the objective of this study is to compare readmission to the emergency department for asthma in asthma patients who receive treatment with fluticasone propionate and salmeterol oral inhaler after an initial emergency department visit using a retrospective observational cohort study design.


Eligibility criteria:
inclusion criteria: * subjects with asthma as determined by icd-9 codes and asthma drug use * at least 12 years of age * discharged from an initial emergency department visit within 12 months exclusion criteria: * subjects with copd or treatment for copd

Keywords: fluticasone/propionate salmeterol combination hospitalization emergency department asthma
role of ultrasonography in airway management

Conditions: Obese Patients

Summary: ultrasound is one of the most useful devices in daily anesthesia practice. latest purpose of ultrasound usage is prediction of difficult intubation. in this study, we aimed to predict difficult laryngoscopy and intubation by using ultrasound measurement of neck soft tissue thickness in obese patient preoperatively.

in this prospective and randomized controlled study, mallampati scores, interincisor gap, thyromental distance, neck circumference measurement and upper lip bite test scores will be recorded in sixty obese patients. additionally, neck tissue thickness will be recorded at 4 different levels (hyoid bone-skin distance, epiglot-skin distance , thyroid istmus-skin distance, vocal cord-skin distance) after the sniffing position by ultrasound with the linear probe. all measurements will be repeated three times and an average values will be recorded. after all this measurements, endotracheal intubation will be performed by an experienced anesthetist who is uninformed about study. during intubation the cormack lehane (c/l, grade 1: full view of the vocal cords; grade 2a: partial view of the glottis; 2b: posterior part of the vocal cord and arytenoids visible; grade 3: only epiglottis visible; and grade 4: neither epiglottis nor glottis visible) and the intubation difficulty scale (ids) score (the numbers of attempts, operators, and alternative techniques used, the c/l grade of laryngoscopic view, lifting force and external laryngeal manipulation required, and position of the vocal cords. every insertion of the laryngoscope and advancement of the tracheal tube towards the glottis counted as an attempt. a score of \>5 indicates moderate-to-major difficulty) will be recorded.

Eligibility criteria:
inclusion criteria: * bmi\>30 * 18-65 years * asa 1-2-3 * obese patients exclusion criteria: * pregnancy * upper airway pathology * cervical spine pathology * laryngeal pathology
a study of clevidipine butyrate injectable emulsion in the treatment of hypertensive emergency and sub-emergency

Conditions: Hypertensive Emergency

Summary: a randomized, double-blind, active-compared phase ш clinical trial to evaluate clevidipine butyrate injectable emulsion in the treatment of hypertensive emergency and sub-emergency.

this is a multicenter, randomized, double-blind, active-compared phase iii clinical study to evaluate the efficacy and safety of clevidipine butyrate injectable emulsion in the treatment of hypertensive emergency and sub-emergency. the cleviprex® will be chosen as the positive controlled medicine with the same usage of the test drug.

Eligibility criteria:
inclusion criteria: 1. age ≥18 years-old and ≤75 years-old, regardless of gender; 2. patients with hypertensive emergency and sub-emergency requiring a rapid intravenous blood-pressure control: patients with sbp \> 180 mmhg and/or dbp \> 120 mmhg (requiring twice consecutive blood pressure measurements, 10 to 15 min apart), with or without target organ damage; 3. a potentially fertile patient is willing and required to use reliable contraceptive methods throughout the study period and for at least 3 months after initiation of test drug to avoid pregnancy in the female patient or in the male patient's partner; 4. able to understand informed consent, participate in the experiment voluntarily and sign informed consent. exclusion criteria: 1. antihypertensive drugs have been used within 2 hours before the administration of test drugs; 2. patients with life-threatening clinical manifestations, such as malignant arrhythmias, respiratory failure, and severe disturbance of consciousness; 3. patients with confirmed or suspected severe aortic stenosis or aortic dissection at screening time; 4. patients with obstructive hypertrophic cardiomyopathy and systolic heart failure at screening time; 5. patients with acute coronary syndrome at screening or myocardial infarction within 1 month before screening; 6. patients with acute stroke within 1 month before screening; 7. patients with clear history of secondary hypertension; 8. patients with lipid metabolism defects; 9. patients with a known history of liver failure or cirrhosis; 10. patients with chronic kidney disease (ckd) stage 5, requiring long-term regular dialysis treatment; 11. patients who are allergic to the test drug or its ingredients, or who are intolerant to calcium channel blockers, or who are allergic to soy, soy products, eggs and egg products; 12. patients with mental illness, mental disorder and other disorders who cannot communicate properly; 13. a history of drug abuse, drug use, or alcohol dependence; 14. female patients who are pregnant or lactating; 15. patients who have participated in other interventional clinical trials within 3 months prior to screening; 16. patients who are judged by the investigators to be ineligible for this study for other factors, such as patients who could not receive intravenous infusion.
use of strattice mesh in paraesophageal hernia surgery

Conditions: Esophageal Hernia; Hernia, Esophageal; Hernia, Paraesophageal; Hiatal Hernia; Paraesophageal Hiatal Hernia; Sliding Esophageal Hernia; Sliding Hiatal Hernia

Summary: the objective of this study is to examine the safety and efficacy of porcine acellular dermal matrix mesh (strattice; lifecell corp., branchburg, nj) in crural reinforcement of laparoscopic large paraesophageal hernia repair.

prosthetic reinforcements reduce recurrence rates; the choice of optimal prosthetic, either synthetic or biosynthetic, for crural reinforcement is controversial. the objective of this study is to examine the safety and efficacy of porcine acellular dermal matrix mesh (strattice; lifecell corp., branchburg, nj) in crural reinforcement of laparoscopic large paraesophageal hernia repair. strattice is a commonly used mesh in hernia repair. 35 adult (\>19 years of age) patients will be selected based on inclusion and exclusion criteria. patients who meet the criteria will be enrolled in the study. information related to recurrence rates based on follow-up visits will be analyzed to determine the efficacy of strattice in the prevention of large hernia recurrence.

Eligibility criteria:
inclusion criteria: * documented symptomatic paraesophageal hernia. * greater than 5 cm hiatal hernia on upper gastrointestinal study. * evidence that the stomach or other viscera is present in the hernia and does not spontaneously reduce from the mediastinum. * significant symptoms or signs of a paraesophageal hernia including but not limited to heartburn, dysphagia, chest pain, shortness of breath, postprandial abdominal pain, early satiety, odynophagia, or chronic anemia. * consenting adult 19 years of age or older * must be able to participate in follow-up evaluation. * free of cognitive impairment exclusion criteria: * children and adolescents (19 years of age or younger). * pregnant and breast feeding patients. * vulnerable subjects such as pregnant women, children less than 19 years age, and decisionally impaired persons. * patients with previous operation of the esophagus or stomach. * patients with associated gastrointestinal diseases that require extensive medical or surgical intervention that might interfere with quality of life assessment (e.g. crohn's disease). * patients with emergent operation for acute gastric volvulus. * patients with known sensitivity to porcine material.

Keywords: esophageal hernia hernia, esophageal hernia, paraesophageal hiatal hernia paraesophageal hiatal hernia sliding esophageal hernia sliding hiatal hernia
physical activity post covid-19

Conditions: Covid19

Summary: this study aims to examine pa trajectory, and potential behaviour-change factors least 12 months after covid-19, across different levels of acute disease severity, and specifically in people with and without long covid.

eligible participants will be contacted and invited for a first visit by a pulmonologist or a respiratory physiotherapist, during which those interested will provide informed consent. participants will be interviewed and medical records reviewed to collect sociodemographic, anthropometric, and clinical data. then, functional capacity, peripheral muscle strength, and lung function will be assessed using several tests, and dyspnoea, fatigue, anxiety, depression, and hrqol through self-administrated questionnaires. finally, people will be provided with a specific device and instructed on its use for measuring daily pa over one week. a pulmonologist, specialized nurse, or technician from the corresponding centre will perform and assess spirometry, while two respiratory physiotherapists will conduct and supervise all other tests in a reserved space at the same centre. the assessments were scheduled at three time points: at least 12 months after hospital/medical discharge (baseline), three and six months afterward.

Eligibility criteria:
inclusion criteria: * at least, 18 years of age; * diagnosis with covid-19; * stable condition at hospital discharge or after 21 days of being treated at home (needed time to recover from an acute respiratory infection; however, patients treated at home should report a negative result in polymerase chain reaction \[pcr\] test). those reporting clinically relevant symptoms among dyspnoea, fatigue, anxiety, depression or impaired health-related quality of life will be considered affected from post-covid-19 condition or long covid. exclusion criteria: * presence of signs of cognitive impairment or significant cardiovascular, neurological, and/or musculoskeletal disease, which may prevent the assessment tests and therefore limit participation. in particular, reasons for exclusion will be the following: cognitive disorders, such as sequelae of alzheimer's disease, senile dementia; comprehension disorders, such as wernicke's aphasia; cognitive-motor disorders, such as hemiparesis/hemiplegia due to stroke; musculoskeletal disorders, such as unconsolidated fractures, external prostheses (including replacements in amputees); cardiovascular disorders, such as unstable angina, recent acute myocardial infarction, among others. * vacination before infection. * reinfections during follow-up.

Keywords: covid19 physical activity exercise capacity functional capacity long covid
a phase ii/iii trial comparing transarterial tirapazamine embolization (tate) with ctace for intermediate-stage liver cancer.

Conditions: HCC

Summary: this phase i/ii clinical trial aims to determine the efficacy and safety of tate compared to tace in patients with intermediate-stage hcc. the results will provide valuable insights into the potential benefits of tate as a novel treatment option for hcc.


Eligibility criteria:
inclusion criteria: * patients diagnosed with primary hepatocellular carcinoma according to aasld criteria. * no evidence of extrahepatic metastasis, regional lymph node involvement, or vascular tumor thrombus. * patients must be eligible for tae or tace treatment. * ecog ≤ 1. * child-pugh score ≤ 7. * adequate bone marrow, liver, and kidney function is required. exclusion criteria: * history of liver transplantation. * previous radioemblization or radiotherapy for liver tumors. * severe cardiovascular or renal diseases, active systemic infections. * clinically significant hypoxia (oxygen saturation \< 92% without oxygen supplementation)
comparison of niv-nava vs. n-cpap after extubation in preterm infants study

Conditions: Endotracheal Extubation; Infant, Premature

Summary: this study is a randomized controlled study to compare if a a non-invasive neurally adjusted ventilatory assist (niv-nava) is better than nasal continuous positive airway pressure (n-cpap) after extubation in infants' \< 30 weeks of gestation.


Eligibility criteria:
inclusion criteria: * postconceptional age less than 30+0 weeks * infants who fulfill the the criteria for extubation for 6 hours extubation criteria: ventilator rate ≤ 25 breaths/min, peak inspiratory pressure (pip) ≤ 16cmh2o, fractional inspired oxygen (fio2) ≤ 0.3 exclusion criteria: * conditions which will decrease life expectancy * major anomalies which will decrease life expectancy * any anomalous conditions which involve upper and lower airway * neuromuscular disease

Keywords: non-invasive ventilation non-invasive neurally adjusted ventilatory assist nasal continuous positive airway pressure
the complement lectin pathway after cardiac arrest

Conditions: Out-of-Hospital Cardiac Arrest; Post Cardiac Arrest Syndrome

Summary: this study includes comatose survivors of out-of-hospital cardiac arrest treated with 24 hours or 48 hours of targeted temperature management. the overall aim is to evaluate the importance of plasma complement protein concentrations in patients resuscitated after out-of-hospital cardiac arrest and treated with 24 hours or 48 hours of targeted temperature management. the specific aim is to evaluate: * the concentration of plasma lectin pathway proteins the first, second and third day after cardiac arrest * the relation between concentration of plasma lectin pathway proteins and mortality * if prolonged targeted temperature management influences the concentration of plasma lectin pathway proteins this study is a sub-study to the trial entitled: "time-differentiated targeted temperature management (tth48) (clinicaltrials.gov identifier: nct01689077)" the following complement lectin pathway proteins will be measured: mannan-binding-lectin, m-ficolin, h-ficolin, cl-l1, masp-1, masp-2, masp-3, map19 and map44.


Eligibility criteria:
inclusion criteria: * out-of-hospital cardiac arrest of presumed cardiac cause * return of spontaneous circulation (rosc) * glasgow coma score \< 8 * age \> 18 years and \< 80 years exclusion criteria: * \> 60 minutes from the circulatory collapse to rosc * time interval \> 4 hours from cardiac arrest to initiation of targeted temperature management * terminal illness * coagulation disorder * unwitnessed asystolia * cerebral performance category 3-4 before the cardiac arrest * severe persistent cardiogenic shock * pregnancy * persistent cardiogenic shock (systolic bloodpressure \< 80 despite inotropic treatment) * new apoplexy or cerebral hemorrhage * lack of consent from the relatives * lack of consent from the general practitioner * lack of consent from the patient
bms-562247 in subjects undergoing elective total knee replacement surgery

Conditions: Venous Thrombosis; Pulmonary Embolism

Summary: the purpose of this study is to learn if bms-562247 can prevent blood clots in the legs and lungs in men and women following unilateral total knee replacement surgery. the safety of this treatment will also be studied.


Eligibility criteria:
inclusion criteria: * undergoing elective unilateral total knee replacement surgery. * willing and able to undergo bilateral ascending contrast venography. * able to inject (by self or caregiver) study medication subcutaneously. exclusion criteria: * women of childbearing potential. * women who are pregnant or breastfeeding. * under some conditions, subjects weighing more than 300 lbs. (136kg) and/or body mass index (bmi) \>=35 kg/m2

Keywords: prevention of deep vein thrombosis and pulmonary embolism preventive therapy
comparison of open and laparoscopic distal gastrectomy for t4a gastric cancer

Conditions: Gastric Cancer

Summary: there are more than 75% of patients with gastric cancer who are diagnosed in advanced stage in vietnam, most of cases in t4a. the purpose of this study is to compare the technical feasibility, early and long term outcomes of open and laparoscopic distal gastrectomy for gastric adenocarcinoma in t4a stage

gastric cancer poses a significant public health problem. it is one of the most common cancers in vietnam . despite recent advances in multimodality treatment and targeted therapy, surgery remains the first option of treament for this disease. for resectable gastric cancer, complete removal of macroscopic and microscopic lesions and/or combined resections and also regional or extended lymphadenectomy should represent in the world now. since laparoscopic gastrectomy for early gastric cancer (egc) was firstly reported in 1994 , this technique has become standard for treatment of egc due to the many advantages of mininally invasive surgery and also in oncologic outcomes. laparoscopic gastrectomy for advanced gastric cancer agc was first applied by uyama in 2000, and then, many surgeons have used it for treatment of agc, especially in japan, korea and china. however, the real role of laparoscop for treament of (agc) is still controversial in term of technical feasibility, safety and oncologic aspect. paragastric inflammatory strands may occur in t4a tumor so that laparoscopic technique is difficult to radically perform. peritoneal seeding of malignant cells, intra- and postoperative complications, trocarts metastasis may risk during procedures. despite, some studies have demonstrated the safety and the short-term benefits of lg for t4a gastric cancer, the number of these studies and sample sizes have been still inadequate to give good evidence for applying it. and long-term oncologic outcomes there are more than 75% of patients with gastric cancer who are diagnosed in advanced stage in vietnam, most of cases in t4a. the purpose of this study is to compare the technical feasibility, early and long term outcomes of open and laparoscopic distal gastrectomy for gastric adenocarcinoma in t4a stage.

Eligibility criteria:
inclusion criteria: * pathologic finding by gastric endoscopy: confirmed gastric adenocarcinoma * age: 18 - 80 year old * tumor located at the middle or lower third of the stomach * preoperative cancer stage (ct scan stage): ct4an0m0, ct4an1m0, ct4an2m0, ct4an3m0 * asa score: ≤ 3 * informed consent patients (explanation about our clinical trials is provided to the patients or patrons, if patient is not available) exclusion criteria: * concurrent cancer or patient who was treated due to other cancer before the patient was diagnosed gastric cancer * had another treatment methods, such as chemotherapy, immunotherapy, or radiotherapy * pregnant patient * combined resection * total gastrectomy

Keywords: gastric cancer laparoscopic gastrectomy t4a stage
rehabilitation in primary care: a project to maximize the health status of adults with chronic illness

Conditions: Chronic Disease; Hypertension; Back Pain; Obesity; Arthritis

Summary: the purpose of the study is to determine whether occupational therapy and physiotherapy delivered in a primary care setting to adults with chronic illness is effective in improving health.

primary health care is changing so that people receive the care that they need at the front line. rehabilitation has been identified as one service that should be offered in primary care, to address the needs of adults who have or are at risk of poor health from chronic conditions such as arthritis, heart disease and depression. two full time therapists (one physiotherapist and one occupational therapist) will offer rehabilitation to a sample of 170 adults with chronic illness over an 18 month period (170 people will also be enrolled in a control group) at the stonechurch family health centre. key outcomes include health, hospital admissions and emergency room visits.

Eligibility criteria:
inclusion criteria: * at least 1 chronic condition * 3 visits to family physician in the past year exclusion criteria: * none

Keywords: occupational therapy physical therapy techniques primary health care chronic disease rehabilitation disease management self care