Kornimate/medical-research-clean huggingface dataset:
compare epidural vs. lumbar plexus analgesia after hip arthroplasty

Conditions: Arthropathy of Hip

Summary: the goal of this retrospective chart review is to evaluate if the implementation of lumbar plexus block placement for postoperative pain have improved conditions in the postoperative period for patients undergoing total hip arthroplasty when compared to the placement of epidurals for postoperative pain management.

primary outcome: 48 hour opiate consumption in patients following tha. ' secondary outcome: time to first ambulation, assistance needed with ambulation, opiate and regional related side effects, time to discharge orders.

Eligibility criteria:
inclusion criteria: * 18 years and older * diagnosis of: 1. primary tha, (identified by cpt code 27130) 2. either a) epidural (cpt code 62319) or b) lumbar plexus peripheral nerve block (cpt 62311 or 64449) * perioperative multimodal medication * hospitalized from july 1, 2012 to december 17, 2014. exclusion criteria: * tha revision * icu admission postoperatively * history of dementia

Keywords: pain, postoperative nerve block anesthesia, epidural
role of the met oncogene in human colorectal cancer - a translational study

Conditions: Colorectal Cancer

Summary: the met oncogene is known to sustain the trousseau's syndrome in murine experimental models, featuring association of carcinogenesis with a blood procoagulant disorder. met is frequently overexpressed in colorectal cancer, a tumor where venous thromboembolism (vte) may occur in association with poor prognosis, but the biological and genetic factors that cause vte are still obscure. the investigators propose to study whether in patients harboring a surgically resectable colorectal cancer the met oncogene is expressed and may be associated with a blood thrombophilic condition that favors the onset of vte. these data would have two main implications: (i) for the first time, a direct genetic link between the met oncogene and a procoagulant disorder would be demonstrated in humans; (ii) the procoagulant alterations would have diagnostic/prognostic significance for the identification of patients at risk for poor outcome, and implementation of appropriate therapeutic protocols.


Eligibility criteria:
inclusion criteria: * age \> or = 18; * age \< or = 80; * clinical diagnosis of colorectal tumor by ct, mri or endoscopy; * surgically resectable tumor; exclusion criteria: * inclusion in other clinical protocols requiring administration of anticoagulant drugs; * life expectancy \< 6 month; * clinical diagnosis of thrombophilic condition by laboratory analysis; * previously implanted central venous catheter; * previous or concomitant second neoplasia; * clinical diagnosis of kidney, liver or heart failure; * inflammatory markers alteration associated with disease unrelated to neoplasia (infection, connective tissue disease etc); * severe hemostasis disorder;

Keywords: resectable colorectal cancer
physical exercise benefits for cancer patients

Conditions: Cancer, Breast; Sports Physical Therapy

Summary: the purpose of the study was to analyze the effect of a synchronous-supervised online home-based group during a 6-month exercise program on physical fitness, body composition and adherence compared to an exercise recommendation group of patients undergoing breast cancer treatment without supervision.


Eligibility criteria:
inclusion criteria: * 18 years old or older * diagnosted with breast cancer * undergoing cancer treatment * no medical contraindications exclusion criteria: * medical contraindications for sport practice * refusal to participate in the study * comorbilities

Keywords: oncology quality of live physical exercise physical activity physical fitness
the genital tract microflora in women with systemic lupus erythematosus (sle) and immunoglobulin a (iga) nephropathy.

Conditions: Systemic Lupus Erythematosus; Immunoglobulin A Nephropathy

Summary: the study hypothesis: systemic lupus erythematosus (sle) is a chronic autoimmune disease with a broad spectrum of clinical manifestations. its mechanisms are not well understood. it is known that its development is influenced by genetic factors and gender. however, it is believed that in some patients with a specific genetic predisposition, certain environmental factors such as chemicals, including drugs and toxins, smoking, or infections may initiate the development of the disease. of particular importance seem to be infections, which by stimulating the immune system can induce new symptoms or exacerbate existing ones. for this reason, links between the microbiome and the clinical course of sle are being sought. most available studies concern the intestinal microbiome. so far, the relationship between the genital tract microbiota and the clinical picture of sle has not been documented. aim of the study: this study aims to identify and differentiate the genital tract microbiota of women with a diagnosis of systemic lupus, iga nephropathy and a control group of healthy women. the results will be correlated with the clinical presentation of these diseases. in addition, the isolated bacterial strains will be secured for further study.


Eligibility criteria:
inclusion criteria: * age \>18 years, * confirmed diagnosis of sle or iga nephropathy, * first half of the menstrual cycle, after the end of bleeding, * signed informed consent to participate in the study. exclusion criteria: * lack of menstruation, * pregnancy, * active infection requiring parenteral or topical antibiotic therapy within 2 weeks before examination, * neoplastic disease of the reproductive tract.

Keywords: microbiome systemic lupus erythematosus iga nephropathy
clinical investigation on the acoustic stimulation in the treatment of chronic tinnitus

Conditions: Chronic Tonal Tinnitus

Summary: there are many treatments for chronic tinnitus that have been claimed, with varying degrees of statistical reliability. none of those treatments can eradicate the tinnitus completely. some therapies can reduce the tinnitus symptoms (loudness, annoyance) up to 30%. thus there is still a need of new treatments that can reduce considerably the tinnitus symptoms and improve the qol of subjects. trial objectives: * the aim of this trial is the improvement of the qol (quality of live) by reducing the tinnitus- symptoms of the patient. * to confirm the efficacy and safety of the coordinated reset technology. these objectives will be assessed: * by subjective and objective measurements of the tinnitus symptoms, loudness and annoyance.


Eligibility criteria:
inclusion criteria: * mentally healthy people * chronic tonal tinnitus * older than 18 years * signature of the patient informed consent * no participation in other tinnitus therapy during the clinical investigation exclusion criteria: * a necessity for hearing aid * auditory hallucination * symptomatic hearing disorders * "morbus meniere", * tinnitus due to temporomandibular joint disorders * subjects who can't perceive therapeutic tones * brainstem diseases * psychiatric disorders * objective tinnitus * insufficient treatment of general disorders, anemia, tumor, dialysis, hypertonus ect.
prostate screening study using mri in brca carriers

Conditions: Prostate Cancer

Summary: men with a brca1 or brca2 mutation are at increased risk for early onset, aggressive prostate cancer compared to men in the general population. standard of care screening for men with a brca mutation includes psa testing and digital rectal examination (dre), the same as with men in the general population. this study is being done to assess whether there is value in using mri as a screening tool to detect prostate cancer at an earlier stage than may otherwise be detected using standard of care screening (psa, dre). it is unclear whether mri has utility as a screening tool in this specific population at high risk for aggressive disease.

to determine the value of using multispectral 3t mri (ms3tmri) for prostate cancer screening in men with a high risk of developing early onset aggressive prostate cancer given known brca1 or brca2 mutation carrier status, with no prior prostate cancer diagnosis, independent of baseline psa levels. * determine the prevalence of prostate cancer in brca1 and brca2 mutation carriers independent of baseline psa levels. * to evaluate the accuracy of tumor targeting based on mri and ultrasound (us) tumor co-localization. to evaluate the sensitivity, specificity, ppv, npv, and accuracy of an automated computer aided diagnosis method (cad) applied to ms3tmri in the prediction of zonal biopsy results for the presence or absence of a significant cancer.

Eligibility criteria:
inclusion criteria: * enrolled in the male hereditary cancer research program at sunnybrook health sciences center. * have positive genetic testing for a pathogenic brca1 or brca2 mutation. * clinically eligible for and willing to undergo ultrasound biopsy within 4 weeks after the mri. * be 50 years of age or older. exclusion criteria: * claustrophobia * contraindication to mri * contraindication to receiving low molecular weight mri contrast agent * previously diagnosed with prostate cancer
learning curve for gastric endoscopic submucosal dissection

Conditions: Endoscopic Submucosal Dissection; Gastric Neoplasm

Summary: endoscopic submucosal dissection (esd) for early gastric cancer is a widely accepted treatment option of expanded indication worldwide. esd is relatively difﬁcult compared with endoscopic mucosal resection, thus, proper training is essential for the safe performance of the procedure. thus, it is necessary to receive proper training in the procedure for safe performance of esd. previous studies reported that there was a learning curve in esd training and preceptees needed to perform at least 30-40 procedures in order to master this technique. however, there is few study about the association between the clinical characteristics and competence level for gastric esd.

this study aims to evaluate the clinical outcomes of esd and to describe the learning curve for esd of the gastric neoplasm, based on the analysis of a single endoscopist's experience.

Eligibility criteria:
inclusion criteria: * pathologically confirmed gastric neoplasm exclusion criteria: * age \< 20 * history of gastric surgery * severe systemic disease * advanced chronic liver disease * recent history of upper gastrointestinal bleeding
a dyadic approach to perinatal depression in primary care: maternal infant and dyadic care

Conditions: Depression, Postpartum; Efficacy, Self; Anxiety

Summary: the purpose of this study is to assess the effectiveness of a parenting intervention+usual care compared to usual care on postpartum depression and other mental health and parenting outcomes, as well as the feasibility and acceptability of the parenting intervention.

eligible and consenting participants will be randomized in a single blind manner (research visitor will be blinded to condition) at a 1:1 ratio to either mind (parenting intervention and usual perinatal collaborative care) or usual collaborative care in their second trimester of pregnancy. research assessments will be administered during pregnancy and post-partum.

Eligibility criteria:
inclusion criteria: * english speaking pregnant women between gestational age (ga) 13 - 24 weeks * ≥ 18 years, * epds score ≥10, * ability to send and receive text messages (tm) exclusion criteria: * severe substance use disorder in the past 6 months (score of 4 or above on the alcohol use disorders test audit-c or a score of 6 or more on the drug abuse screening test (dast). * active suicidal ideation as measured by follow up to a positive answer to question 10 on the epds. * bipolar disorder (composite international diagnostic interview score ≥7) or psychotic disorder (assessed by chart review); * multiple gestation (assessed by self-report and medical record); * ongoing active treatment with psychotropic medications by mental health specialist (but not a pcp or obstetrician).
new breath actuated mdi symbicort compared to symbicort pmdi and budesonide pmdi for 12 weeks twice a day

Conditions: Asthma

Summary: this is a comparison of the efficacy of the symbicort breath actuated dose inhaler to the symbicort pressured meter dose inhaler after 12 weeks of a twice a day dose.


Eligibility criteria:
inclusion criteria: * male or female 12 years and above * clinical diagnosis of asthma according to the american thoracic society definition at least 6 months * pre-bronchodilator fev1 ≥ 45% and ≤ 85% of predicted normal * patients with reversible airway obstruction * documented daily use of inhaled corticosteroids for ≥ 3 months exclusion criteria: * history of life-threatening asthma, defined for this protocol as an asthma episode that required intubation and/or was associated with hypercapnea, respiratory arrest or hypoxic seizures during the 2 years prior to visit 2 * hospitalized during previous 6 months for asthma * required emergency treatment more than once during previous 6 months for an asthma-related condition * intake of oral, rectal or parenteral glucocorticosteroid within 30 days of enrolment * respiratory infection affecting the asthma within 30 days
sutures vs. staples skin closure after c-section in obese patients

Conditions: Obesity; Pregnancy

Summary: this is a randomized prospective clinical trial designed to determine the wound complication rates for stainless steel staples versus subcuticular suture for skin closure in the obese parturient (bmi≥ 30kg/m2) undergoing cesarean delivery.


Eligibility criteria:
inclusion criteria: * 18 years or older * bmi ≥ 30kg/m2 on admission to labor and delivery * patient is for scheduled cesarean delivery or in non-emergent labor but has an indication for cesarean delivery * singleton pregnancies * gestational age ≥ 24weeks * cesarean delivery performed under regional anesthesia exclusion criteria: * refusal to participate * bmi \< 30kg/m2 * \< 24 weeks gestation * intrauterine fetal demise * chronic pain syndrome requiring chronic narcotic use * emergent clinical situations which preclude obtaining informed consent

Keywords: cesarean delivery wound complications skin closure methods
clinical analysis of suction drainage in cementless hip replacement

Conditions: Arthropathy of Hip

Summary: randomized prospective study assessing suction drainage in total hip arthroplasty. group without drainage, 50 hips, compared with group with suction drainage, 50 hips. both groups will be asses clinically (rom scale, vas), laboratory and radiology (usg). in the actually literature there are no benefits using closed suction drainage after primary total hip arthroplasty.


Eligibility criteria:
inclusion criteria: * age between 30-80 * primary hip osteoarthritis exclusion criteria: * secondary hip osteoarthritis * autoimmune disease * congenital or secondary coagulopathy * vein or artery thrombosis * renal or liver failure * cemented or hybrid alloplasty, * no consent from the patient

Keywords: hip arthroplasty suction drainage
radiomic and pathomic study of pituitary adenoma using machine learning

Conditions: Pituitary Neoplasms

Summary: refractory pituitary adenoma is characterized by invasive tumor growth, continuous growth and/or hormone hypersecretion in spite of standardized multi-modal treatment such as surgeries, medications or radiations. quality of life or even lives are threatened by these tumors. according to the 2017 world health organization's new classification guideline of pituitary adenoma, patients have to suffer from symptoms or complications caused by these tumors, to bear a heavy financial burden, and to accept additional therapeutic side effects when the diagnosis of "refractory pituitary adenoma" is made. if refractory pituitary adenoma could be predicted at early stage, these patients would be able to have a more frequent clinical follow-up, receive multiple effective treatment as early as possible, or even be enrolled in clinical trials of investigational medications, so as to prevent or delay the recurrence or persistent of the tumor growth. therefore, the unmet clinical need falls into an early prediction system for refractory pituitary adenomas, which could provide accurate guidance for subsequent treatment in the early stage. the investigators have constructed a pituitary adenoma database including clinical data, radiological images, pathological images and genetic information. the investigators are proposing a study using machine learning to extract features from these multi-dimensional, multi-omics data, which could be further used to train a prediction model for the risk of refractory pituitary adenoma. the proposed model would also be validated in another prospectively collected database. the established model would be able to identify potential medication targets and provide guidance for personalized therapy of refractory pituitary adenoma.


Eligibility criteria:
inclusion criteria: * all patients with pituitary adenoma exclusion criteria: * patients who were not able to sign the informed consent
magna graecia evaluation of comorbidities in patients with heart failure study

Conditions: Heart Failure

Summary: the magic-hf study project (magna graecia evaluation of comorbidities in patients with heart failure study), is an observational prevalence and incidence study focusing on the role that risk factors, various comorbidities, and their treatment may have on cv and non-cv outcomes in patients with all forms of hf. it also aim to assess whether comorbidities and their treatment may be predictors of response to pharmacological and non-drug treatment of hf.

adult subjects with all forms of hf (hfref, hfmref, hepef) with at least one comorbidity who are referred to the heart failure outpatient clinic of the aou "mater domini" geriatrics unit in catanzaro will be recruited. initially, patients will be evaluated at baseline and followed-up for a minimum of six-month. all patients will be subjected to clinical, instrumental and laboratory examinations, including medical history data collection and complete anthropometric assessment . plasma and serum samples will be collected at recruitment and at the six-months follow-up visit. stool samples will also be obtained and stored at -80c for the omics studies.

Eligibility criteria:
inclusion criteria: * informed consent obtained before performing any procedure * age\>18 years old * confirmed diagnosis of hfref, hfmref, hfpef with clinical stability for at least 4 weeks * presence of at least one of the following comorbidities: * atrial fibrillation * peripheral arteriopathy * hypertension * chronic ischemic heart disease * diabetes mellitus type 2 or insulin resistance * hepatopathy * obesity * cancer * sleep apnea syndrome * chronic kidney disease * iron deficiency * cognitive decline or depression * sarcopenia * dysthyroidisms * hypovitaminosis d * hyperuricemia exclusion criteria: * liver cirrhosis child-pugh c * severe chronic renal failure defined by an estimated glomerular filtration rate (egfr) value \< 15 ml/min/1.73 m2 according to ckd-epi * suspected alcohol or drug abuse * pregnancy or breast feeding

Keywords: heart failure biomarkers cardiovascular complications prevention
a study to assess gw677954 used in combination with insulin in subjects who have type 2 diabetes mellitus

Conditions: Type 2 Diabetes Mellitus; Diabetes Mellitus, Type 2

Summary: many drugs used for the treatment of type 2 diabetes mellitus cause the body to retain water. this study will assess whether or not gw677954 causes the body to retain fluid.


Eligibility criteria:
inclusion criteria: * have been diagnosed by a doctor with type 2 diabetes mellitus at least 3 months before screening * have a body mass index within range 25 to 40.0kg/m2 inclusive * females who meet above criteria must be physiologically incapable of becoming pregnant (ie., surgically sterilized, or post-menopausal per protocol definition) exclusion criteria: * significant weight loss or gain in the 3 months before screening * have used insulin to treat hyperglycemia within 3 months before screening * have a history of fluid retention * have uncontrolled high blood pressure * have liver disease * take loop diuretics (water pills), certain blood thinners, and/or st. johns wort. - have or have had certain kinds of cancer

Keywords: nabr sodium bromide dexa deuterium total body water insulin d2o gw677954 randomized withdrawal t2dm
effect of low-pressure pneumoperitoneum on pain and inflammation in laparoscopic cholecystectomy

Conditions: Pneumoperitoneum; Pain; Inflammatory Response

Summary: the purpose of this study is to assess the effect of low-pressure pneumoperitoneum on post operative pain and inflammation in patients undergoing elective laparoscopic cholecystectomy by comparing it to standard practice.

after obtaining informed consent from eligible study participants. patients were randomized into one of two masked groups, labelled red and green. the red-label group was operated at standard-pressure pneumoperitoneum, while the green-label group was operated at low-pressure pneumoperitoneum. baseline blood samples were obtained pre-operatively for ten inflammatory markers, patients' demographics and intra-operative details collected, then post-operative pain and change in inflammatory markers were followed.

Eligibility criteria:
inclusion criteria: - elective admission for laparoscopic cholecystectomy exclusion criteria: * current or previous diagnosis of acute cholecystitis confirmed by ultrasound * previous gi surgeries, except bariatric and anti-reflux surgeries * currently on immunosuppressant agents * pregnancy * breastfeeding * currently diagnosed with drug addiction * american society of anesthesiologists (asa) score 3 and more

Keywords: clinical trial low pressure insufflation pneumoperitoneum laparoscopic cholecystectomy pain inflammatory marker
early intervention for information processing speed deficits in acute sci: a pilot study

Conditions: Spinal Cord Injuries; Cognitive Dysfunction; Cognitive Impairment; Acute Spinal Cord Injury

Summary: this study seeks to conduct a pilot study to test whether a cognitive training program can improve processing speed abilities in individuals with acute traumatic spinal cord injury.

spinal cord injury (sci) newly affects approximately 18,000 persons in the us per year. decades of research have focused on the physical limitations associated with sci, as well as therapies for addressing these physical problems. however, it is becoming better acknowledged that many individuals experience significant problems with their cognitive abilities, such as attention, memory, and the time it takes them to process information. research has shown that people who have cognitive difficulties, compared to those with a purely physical disability, are less likely to be employed, engage in fewer social and work-related activities, have greater difficulties carrying out routine household tasks, and are at higher risk for mental illness. if cognitive issues arise after an sci, it is more likely that a person would have a more challenging time adapting the many lifestyle changes brought about by their injury, would benefit less from their rehabilitation program, and have more difficulty rejoining the workforce. as it stands, cognitive assessment or rehabilitation is not part of the standard of care for individuals after their sci because of the relative lack of research in this area. this study seeks to conduct a multisite pilot study to test whether a cognitive training program can improve processing speed abilities in individuals shortly after they experience their sci, with the hopes that this early intervention will improve the trajectory of their overall health and well-being.

Eligibility criteria:
inclusion criteria: * 18-65 years old * recent traumatic sci (approximately 6 months post-injury) exclusion criteria: * no other significant neurological, psychiatric or substance use history * no significantly impairing visual disturbance

Keywords: processing speed