Kornimate/medical-research-clean huggingface dataset:
ampicillin for dyt-1 dystonia motor symptoms

Conditions: DYT-1; Dystonia

Summary: the purpose of this study is to evaluate if the antibiotic ampicillin is safe and tolerated in patients that have generalized dystonia caused by the dyt-1 gene mutation, as compared to patients treated with a placebo. a placebo is a pill that looks and tastes the same as the real drug, but without the active ingredient. the second objective of this study is to determine if dystonia symptoms improve while on the study drug.

this is a double-blinded and randomized drug study: neither the patient nor the investigator know if patients are taking study drug (ampicillin) or placebo. three study visits will include neurological exams, review of medical history, genetic test results and video-taped bfm-drs motor scales. patients will receive medication during baseline visit, consisting of either ampicillin drug or placebo, which will be consumed twice daily for 28 days. following a washout period (no drugs) of 7 days, patient will return to clinic for second study visit and receive second set of medication (placebo -vs- ampicillin). medication will be consumed twice daily for 28 days, with patient returning to clinic after a washout period of 7 days for final study visit in clinic.

Eligibility criteria:
inclusion criteria: * dyt-1 dystonia, confirmed by genetic testing * between ages of 7 and 80 years * bfm-drs score greater than 6 exclusion criteria: * negative dyt-1 dystonia gene test * allergy to penicillins or cephalosporins * concurrent bacterial, viral or fungal infection at time of enrollment * pregnancy * inability to follow study protocol * lactose intolerance (placebo contains lactose powder)

Keywords: dystonia dyt-1 ampicillin
a retrospective study to evaluate the conformis iuni, iduo & itotal® krs

Conditions: Osteoarthritis, Knee; Knee Osteoarthritis

Summary: this study is designed to evaluate implant survivorship, patient satisfaction, and patient-reported outcomes of subjects who have undergone surgery with any of the following conformis knee implants: the iuni®, iduo® or itotal® cruciate retaining (cr) knee replacement systems.

this study is designed to evaluate implant survivorship, patient satisfaction and patient-reported outcomes of subjects who have undergone surgery with any of the following conformis knee implants: the iuni®, iduo® or itotal® cruciate retaining (cr) knee replacement systems.this study is a retrospective, single-center study, with one single remote follow up contact. patients will be contacted either by phone or email for a single remote follow-up. retrospective data will be collected from medical records including pre-operative, operative and any follow up visits which have occurred since implantation as available.

Eligibility criteria:
inclusion criteria: * previously underwent surgical implantation of a conformis iuni, iduo or itotal knee replacement. * subject must be greater than 18 years of age.

Keywords: osteoarthritis total knee arthroplasty tka tkr patient specific conformis
radiologic score and failure of conservative management of adhesive small bowel obstruction

Conditions: Small Bowel Obstruction; Conservative Management; Imaging

Summary: the management of acute adhesive small bowel obstruction remains challenging for the digestive surgeon. the bologna guidelines recommend that conservative management of asbo. the literature reports that this form of management has a failure rate between 10 and 40%. a radiological score has been proposed and was associated with an increased risk of failure of conservative management. this tool is promising to select patients further requiring surgery but it has to be assessed in a multi centric prospective cohort.


Eligibility criteria:
inclusion criteria: * all the consecutive patients admitted for initial non-surgical management for asbo * during the period of inclusion exclusion criteria: * the cause of sbo was functional or other than adhesive * patients requiring initial surgical management. * absence of computed tomography performed at admission
stroke and cpap outcome study: a sham-controlled trial of cpap among stroke rehabilitation patients

Conditions: Stroke; Sleep Apnea, Obstructive

Summary: the purpose of this study is to assess the effect of continuous positive airway pressure (cpap) on functional outcome in patients with acute stroke, the investigators conducted a sham-controlled, double-blind pilot trial during inpatient rehabilitation. patients with acute stroke were recruited and randomly assigned to auto-titrating or sham-cpap during their rehabilitation stay.

all acute stroke patients admitted to the inpatient rehabilitation service at the university of washington were invited to participate in the study. given the high prevalence of obstructive sleep apnea (osa) in this population, no screen for osa was performed. enrolled patients were assigned randomly to active-cpap with auto-titrating pressures or to sham-cpap with an otherwise identical device but with pressures ≤ 1 cm water. subjects used active or sham-cpap for the duration of inpatient rehabilitation, but no longer than 28 days. cpap compliance was assessed by memory card that recorded mask-on time. other information on download, such as apnea-hypopnea index, was only available on active-cpap and not assessed by investigators in real time. in this study, the investigators defined tolerance as any continued use of cpap at night and adherence as mean hours of cpap use per night in those who were cpap tolerant.

Eligibility criteria:
inclusion criteria: * greater than 18 years of age * admitted to an inpatient rehabilitation unit at the university of washington * head ct or brain mri demonstrating an ischemic or hemorrhagic stroke * enrolled in another research study exclusion criteria: * stroke was a subarachnoid hemorrhage or due to a secondary cause (vascular malformation, vasculitis, brain tumor, head trauma, or predisposition to bleeding) * history of cpap use, advanced chronic lung disease requiring supplemental oxygen, heart failure (nyha class iii or iv) * require a nasogastric feeding tube.

Keywords: rehabilitation continuous positive airway pressure
management of mandibular orn: pento as medical treatment

Conditions: Osteoradionecrosis

Summary: mandibular osteoradionecrosis, despite its low incidence, remains being the most problematic and irreversible complication after head and neck radiotherapy with no medical treatment to limit or reduce symptoms. different clinical trials have shown a significant scientific evidence that the treatment with pentoxifylline + tocopherol achieves a certain effectiveness in the treatment of the tissue fibrosis. this study proposes to use this drugs to determine if there is healing of mandibular osteoradionecrosis and/or a symptomatic improvement as well.

mandibular osteoradionecrosis which occurs after the use of radiation therapy for the treatment of head and neck cancer remains being the most problematic and irreversible complication despite its low incidence with no medical treatment to limit or reduce symptoms. clinical trials conducted to date have shown a significant scientific evidence that the treatment with pentoxifylline + tocopherol achieves a certain effectiveness in the treatment of the tissue fibrosis that have been irradiated based on the properties of this drugs in increased tissue oxygenation and their antioxidant effect. the aim of this study is to determine if there is a clinical improvement of mandibular osteoradionecrosis using pentoxifylline in combination with tocopherol as treatment because, currently, there is no effective treatment to achieve bone healing and/or a symptomatic improvement.

Eligibility criteria:
inclusion criteria: * over 18 years and under 90 years old. * patients who have received radiotherapy after being diagnosed with head and neck cancer and currently are diagnosticated of mandibular osteoradionecrosis (any clinical stage) * follow-up for at least a year after the radiation treatment is completed. * absence of tumor at the time of recruitment. * patients with the capacity to give informed consent exclusion criteria: * allergy or hypersensitivity to pentoxifylline or others xanthines, or to tocopherol (vitamin e). * patients taking oral anticoagulants (acenocoumarol, warfarin). * known hemorrhagic/coagulation disorder. * vitamin k deficiency due to any cause. * use of estrogens oral contraceptives. * serious bleeding or extensive retinal hemorrhage. * ischaemic heart diseases, including recent myocardial infarction. * serious cardiac arrhythmia. * severe liver disease. * severe renal failure (creatinine clearance \<30 ml/min). * hypotension. * female patients who are pregnant or lactating * any other situation or condition that, in the opinion of the investigator, may interfere with optimal participation in the study.

Keywords: mandibular osteoradionecrosis tocopherol pentoxifylline vitamine e wounds and injuries antioxidants free radical scavengers radiation-protective agents vasodilatadors agents osteonecrosis mandible extraoral fistula exposed bone necrotic bone head and neck radiotherapy
allogeneic hematopoietic stem cell transplantation in hiv-1 infected patients

Conditions: HIV-1 Infection

Summary: the purpose of this study is to assess the impact of allogeneic hematopoietic stem cell transplantations (hsct) in hiv infected patients on the persistence of hiv and the hiv immune response.

1. to assess the impact of hsct on the immune response to hiv by measuring hiv specific antigens in peripheral blood (via immune assays such as elisa and western blot) longitudinally. 2. to measure the decay of persisting hiv by sequencing and quantitating hiv rna in plasma, and hiv dna and rna in peripheral blood cells including cd4+ t cells and cd4+ t cell subsets, as well as in tissue cells derived from fine needle lymph node aspirates, and/or bone marrow aspirates, and/or rectal tissue. 3. to determine the presence of the ccr5 delta 32 allele in the patient prior to and following hsct which will provide information regarding the presence of this gene in the donor cells. 4. to correlate these findings to the clinical outcome of the individuals enrolled in this study based on their clinical standard of care assessments following hsct.

Eligibility criteria:
inclusion criteria: * hiv-1 infection, requiring allogeneic, haematopoietic sct as determined by their treating physician (haematologist). * over 18 years of age * provision of written, informed consent exclusion criteria: * in the opinion of the investigator that the patient is not able to provide informed consent * hb \< 9 (g/dl) * cd4+ t cell count \<100 (cells/µl) * serious coagulation abnormalities, platelet count \< 50. * patients currently taking medications that significantly affect the bleeding time (e.g. warfarine, clexane, fxa antagonists) * history of allergy to local anaesthetics * pregnancy

Keywords: hiv persistence reservoirs stem cell transplant functional cure
evaluation in individuals with copd and asymptomatic individuals

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the literature does not provide sufficient information on the evaluation of frailty, handgrip strength, physical activity, kinesiophobia, and fatigue in elderly individuals with chronic obstructive pulmonary disease and asymptomatic elderly individuals. additionally, there is a gap in the literature regarding the impact of copd on these parameters in geriatric individuals diagnosed with chronic obstructive pulmonary disease . to fill this gap in the literature and to establish treatment approaches based on the results of parameters studied in elderly individuals with chronic obstructive pulmonary disease in future studies.

chronic obstructive pulmonary disease (copd) is a prevalent condition among the elderly population, considered a leading cause of morbidity and mortality. it is characterized by chronic inflammatory responses associated with harmful particles or gases in the airways and lungs, resulting in persistent airflow limitation that is both preventable and treatable . while cough and sputum are reported as clinical symptoms in copd cases, the most prominent clinical symptom is dyspnea. age-related physiological changes and frailty lead to a decrease in levels of physical activity. the resulting deconditioning from reduced physical activity causes a decline in ventilation quality, creating a vicious cycle that progressively exacerbates dyspnea. this study involves the comparison of individuals diagnosed with copd with asymptomatic geriatric individuals. its aim is to examine the effects of copd on frailty, handgrip strength, physical activity, kinesiophobia, and fatigue.

Eligibility criteria:
inclusion criteria: * inclusion criteria for copd patients: * having received a diagnosis of copd * being 65 years of age or older * volunteering to participate in the study * not having any mental or communication issues that would hinder the completion of the questionnaires to be used in the research * inclusion criteria for asymptomatic individuals: * not having received a diagnosis of copd * being 65 years of age or older * volunteering to participate in the study * not having any mental or communication issues that would hinder the completion of the questionnaires to be used in the research exclusion criteria: * exclusion criteria for copd and asymptomatic individuals: * having a diagnosis of both physical and mental illnesses * being diagnosed with unstable copd * having conditions such as unstable angina, prior heart attack, uncontrolled hypertension, cancer, and neurological disorders accompanied by functional limitations * currently being addicted to alcohol or substances * having severe visual and hearing impairments * having undergone major surgery in the past few months * having a history of recurring significant clinical infections.

Keywords: pain muscle strength kinesiophobia
20k distributed learning challenge

Conditions: Non Small Cell Lung Cancer

Summary: machine learn a predictive model from more than 20.000 non-small cell lung cancer patients from more than 5 health care providers from more than 5 countries.

all current innovations in medicine, including personalized medicine; artificial intelligence; (big) data driven medicine; learning health care system; value based health care and decision support systems, rely on the sharing of data across health care providers. but sharing of data is hampered by administrative, political, ethical and technical barriers(sullivan et al., 2011). this limits the amount of health data available for the above innovations and life sciences in general as well as other secondary uses such as quality improvement. the investigators hypothesize that sharing questions rather than sharing data is a better approach and can unlock orders of magnitude more data while limiting privacy and other concerns. an infrastructure to bring questions to the data has been demonstrated to work recently in project such as eurocat(lambin et al., 2013; deist et al., 2017), datashield (gaye et al., 2014) and ohdsi (hripcsak et al., 2015). however, the scale of the prior work has been limited in terms of the number of data subjects, number of data providers and global coverage. in the experience of the investigators, the main challenges of scaling up the infrastructure are 1) the effort necessary to make data fair at each site ("stations"), 2) the technical and legal governance ("track") and 3) the mathematics and engineering of learning applications ("trains") - together called the personal health train (pht) infrastructure. since multiple years a global consortium of healthcare providers, scientists and commercial parties called coral (community in oncology for rapid learning) have worked on all three pht challenges. the aim of this study is to show that the pht distributed learning infrastructure can be scaled to many 1000s of patients, specifically the investigators aim to machine learn a predictive model from more than 20.000 non-small cell lung cancer patients from more than 5 health care providers from more than 5 countries.

Eligibility criteria:
inclusion criteria: * non small cell lung cancer * treated in one of the participating hospitals exclusion criteria: * no non small cell lung cancer * not treated in one of the participating centers
randomized comparative study of sleeve gastrectomy versus mgb and sasi bypass , randomized study

Conditions: Diabetes Mellitus Type 2 in Obese

Summary: the investigator randomized and compare the efficacy of 3 types of metabolic surgery in the treatment of type 2 diabetes in obese patients, one of them is sasi bypass which is a modification of santoro's operation by performing a loop rather than roux-en-y bipartition reconstruction and the investigator are reporting the first comparative clinical trial as regards the clinical results of the outcomes of sasi bypass as a mode of functional restrictive and neuroendocrine modulation therapeutic option for obese type 2 diabetes.

from 2011 to 2017, investigators randomized and collect data for the 3 operations sasi bypass , mini gastric bypass and sleeve gastrectomy ) about thorough history, clinical examination and laboratory investigations including basic preoperative investigations, lipid profile, thyroid and suprarenal hormonal evaluation. in addition, patients may undergo further assessment for pulmonary functions or gastroesophageal disease including endoscope. . abdominal ultrasound was done to exclude gall stones and to evaluate the degree of fatty liver. reduction the size of fatty liver was done by putting all patients on low-calorie protein diet for 6 weeks. deep vein thrombosis prophylaxis started 12 h before surgery with low molecular weight heparin subcutaneous injections . preoperative data included age, gender, initial weight, initial body mass index (bmi), obesity complications and treatment medications used (chest problems, diabetes, arterial hypertension and cardiac ischaemia, hyperlipidemia, obstructive sleep apnea syndrome, gall stones, urinary stress incontinence, joint pain, depression, infertility and heart burn). postoperative data included hospital stay, early postoperative complications during the first month (e.g. fever, collection, bleeding, vomiting, leak and port site problems .long-term complications more than 1 month after surgery (e.g. nausea, vomiting, reflux, stricture, intestinal obstruction , hypoalbuminemia , anemia and calcium or iron or vitamin d , vitamin b12 deficiency and), excess weight loss and bmi were collected.

Eligibility criteria:
inclusion criteria: type 2 diabetic obese patients exclusion criteria: * patients age above 65 or below 18 years old * history of upper laparotomy * unfit for anesthesia or laparoscopy * major psychological instability * drug abuse

Keywords: sleeve gastrectomy , mgb , type 2 diabetes , obesity , sasi
effects of exercise training in patients with atrial fibrillation and sleep apnea: a pilot study

Conditions: Sleep Deprivation

Summary: background: there are still many gaps in research concerning the effect of different physical training modalities on sleep deprivation in the population with different types of sleep apnea. aims: the purpose of this study was to examine the effect of moderate-intensity interval training (mitt) on patients with different types of sleep apnea.

methods: 15 participants aged 45-65 years were randomized into two groups: obstructive sleep apnea group (osa), and central sleep apnea group (csa). the training lasted ten consecutive weeks with 30 uninterrupted sessions. the actigraph together with the pittsburg sleep quality index (psqi) was used in sleep quality assessment. the actigraph (actiwatch minimitter company, incorporated (inc) - sunriver, or, usa) was placed on the non-dominant wrist and activities were monitored continuously while being recorded at one-minute intervals. the participants kept the device for a period of 96 hours, filled psqi, and did 6mwt before the first and last training sessions.

Eligibility criteria:
inclusion criteria: 1. patients who have af confirmed by ecg 2. their ages range from 45 and 65 years of age 3. medically stable patients. 4. current complaint of poor sleep quality (sq) (score \> 5 of the sq scale) 5. patients who have osa or csa confirmed by polysomnography exclusion criteria: * any patient was known to have any unstable medical condition;or with any known musculoskeletal or neurological conditions that might interfere with the execution or the assessment of the exercise, was excluded from the study.
dbs and respiration

Conditions: Parkinson Disease

Summary: patients referred to neurosurgery routinely and safely undergo deep brain stimulation (dbs) for treatment of neurological conditions, most commonly parkinson's disease. the investigators have observed that respiratory problems (breathlessness) sometimes occur subsequent to dbs of the subthalamic nucleus (stn). this study aims to determine whether this is indeed a consequence of stn stimulation. secondary objectives include identification of the respiratory physiological mediators of any interoceptive neuromodulation observed, changes in daily physical activity and mri structural connectivity analysis.

a continuous cohort of parkinson disease patients planned to undergo stn-dbs will be approached to participate in this study (i.e. every patient will be offered participation in the study). over the same time period other dbs patients (gpi and vim) will be approached before their implantation procedure to participate as controls/comparators. participants will all be offered the full study, but will also be free to participate in a smaller number of activities if so chosen. patients will be assessed both pre-operatively and post-operatively where they will complete a compound respiratory questionnaire and tests of respiratory interoception and function. post-operatively, these tests will be carried out with stimulation on and off, the order of which will be randomised between patients. data on daily activity will be collected during pre- and post-operative windows, using a wearable pedometer/heart-rate monitor. positive findings of respiratory neuromodulation will be correlated between patients with structural connectivity (e.g. stn-insula.) from pre-operative mri scans.

Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the study. * male or female, aged 18 years or above. * planned for required dbs surgery * fluent in the english language * for experimental group: diagnosed with parkinson's disease exclusion criteria: * female who is pregnant * subject is currently participating in a clinical investigation that includes an active treatment arm which may affect the respiratory system. * acute respiratory problem at time of experimental session: e.g. rhinosinusitis, pharyngitis, asthma exacerbation

Keywords: parkinson disease movement disorder dyspnoea dyspnea breathlessness respiratory
brain energy metabolism in patients with chronic liver disease and impaired central nervous system

Conditions: Cirrhosis; Hepatic Encephalopathy

Summary: the purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.


Eligibility criteria:
inclusion criteria: * 6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy, * 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy, * 6 healthy subjects age and sex matched exclusion criteria: * neurological and/or psychiatric condition, * non-treated diabetes, * pregnancy/breast-feeding

Keywords: ammonia astrocytes citric acid cycle alpha ketoglutarate dehydrogenase