Kornimate/medical-research-clean huggingface dataset:
effects of aerobic exercises in patients with low back pain

Conditions: Low Back Pain

Summary: the aim of this study is to test the feasibility of a clinical trial testing the effectiveness of aerobic exercises program in patients with chronic non-specific low back pain.

a total of 30 patients with chronic non-specific low back pain (with a duration of at least 12 weeks) who are seeking for treatment will be recruited. these patients will be randomly allocated into two groups. patients allocated to the placebo group will be treated twice a week for a total of 12 weeks with detuned ultrasound and shortwave therapy patients allocated to the exercise group will be trained with aerobic exercises on a treadmill twice a week for a total of 12 weeks. primary outcomes will be pain and disability. feasibility outcomes will be adherence, satisfaction and recruitment. kinesiophobia, perceived global effect and physical capacity will also be analyzed as secondary outcomes. the outcome assessor of this trial will be blinded to the group allocation.

Eligibility criteria:
inclusion criteria: * patients with chronic non-specific low back pain with a pain intensity of at least 3 points at the baseline assessment measured by the numerical pain scale, between 18 and 80 years of age and able to read portuguese. exclusion criteria: * patients who have some contraindication to exercise, fractures, tumors, inflammatory and infectious diseases, severe cardiovascular and metabolic diseases, and the development of chronic inflammatory diseases (eg, dyspnoea, limiting diseases of the lower limbs, previous spinal surgery and pregnancy.

Keywords: back pain low back pain
cognitive deficits in major depressive disorder and bipolar disorder, depressed type: prevalence and improvement with treatment of depressive symptoms

Conditions: Major Depression; Bipolar Disorder

Summary: the purpose of this research study is to learn more about cognitive deficits in people with certain mood disorders. the mood disorders are major depressive disorder (mdd) and bipolar disorder, depressed type. cognitive deficits are problems with things like thinking and memory. people with cognitive deficits may have problems concentrating and paying attention. when talking, they may have trouble recalling a word they want to say. they may think slowly and have problems remembering things. these deficits can affect an individual's ability to work and function socially. cognitive deficits that occur with depression may increase the risk of a relapse of major depressive disorder. we want to study the course of cognitive impairment in subjects as they are receiving treatment for their depression. we want to find out if their cognitive deficits get better, worse, or stay the same. we also want to learn more about a stress hormone called cortisol that is produced in the body. we want to study the relationship between cortisol and cognitive impairment. recent research has shown that cognitive impairment may be more severe in people who have high levels of cortisol in their blood. we will also measure the levels of a protein in your blood called brain-derived neurotrophic factor (bdnf). bdnf helps the growth of new brain cells. it appears that the growth of new brain cells lessens when people are depressed. treatment with antidepressant medications may cause bdnf levels to increase and return to normal. we are interested in studying the relationship between bdnf levels and cognitive impairment throughout treatment.


Eligibility criteria:
inclusion criteria: 1. eligible subjects will be inpatients admitted to the massachusetts general psychiatric inpatient service, blake 11 with diagnoses of mdd with and without psychotic features and bpdd with and without psychotic features. 2. subjects will include men and women aged 18-85. 3. competent to give informed consent. exclusion criteria: 1. patients with illnesses that impair cognitive functioning including: vascular dementia, and neurological illnesses including parkinson's disease, huntington's disease, multiple sclerosis, and alzheimer's disease. 2. the following dsm-iv diagnoses: schizophrenia, schizoaffective disorder, delusional disorder, organic mental disorder, substance use disorders including alcohol, active within the past 6 months, acute bereavement, and psychotic disorder not elsewhere classified. 3. pregnant women
evaluation of corneal temperature by infrared thermography in glaucoma patients

Conditions: Glaucoma

Summary: measurement of corneal temperature gives indirect information about the ocular blood flow. for this reason corneal temperature can be used as a surrogate to quantify ocular blood flow. it can be measured by means of infrared thermography. this test, however, is not used in an everyday clinical routine so far. in this study is investigated if ocular blood flow disturbances in glaucoma patients can be diagnosed by means of infrared thermography. corneal temperature are measured in normal tension glaucoma patients and healthy controls before and after cold provocation test. in the group of patients and the group of controls, subjects with and without a primary vascular dysregulation (pvd) are included. this will allow to analyze and compare the influence of cold provocation on corneal temperature (and indirectly ocular blood flow) in these study groups.


Eligibility criteria:
inclusion criteria for patients: * glaucoma * age 18-65 exclusion criteria for patients: * no glaucoma * alcohol consumption * smoking inclusion criteria for control: * no glaucoma * age 18-65 exclusion criteria for control: * alcohol consumption * smoking
mobile behavioral parent training for childhood adhd: pilot trial

Conditions: Attention Deficit Hyperactivity Disorder

Summary: the goal of the study is to develop and pilot a personalized behavioral parent training intervention for caregivers of children with attention deficit hyperactivity disorder. the behavioral intervention will teach positive parenting through videos and quizzes that caregivers can access through a smartphone application. the program also gives parents and caregivers in-the-moment feedback their use of parenting strategies. the main questions to answer are: is parenting feedback provided by a smartphone application acceptable to caregivers? is the phone application usable and acceptable to parents and caregivers of children with attention deficit hyperactivity disorder? in the pilot trial, participants (parents/caregivers) will be randomly assigned to either (1) use the positive parenting intervention phone application (mobile behavioral parent training: mbpt) or (2) use mbpt and receive brief, personalized phone prompts throughout their participation that target parenting behavior and intervention engagement.


Eligibility criteria:
inclusion criteria: * currently meets diagnostic statistical manual 5 diagnostic criteria for adhd * ages 7 -12 * has at least one parent or primary caregiver who is willing to participate and is able to access the intervention at home via smartphone. exclusion criteria: * n/a
endoscopic fundoplication with muse system

Conditions: Gastro-esophageal Reflux; Endoscopic Fundoplication

Summary: this is a spontaneous, prospective, monocentric, observational, cohort study, with the aim of evaluating the effect of ultrasound-guided endoscopic fundoplication using the medigus ultrasonic surgical endostapler (musesystem; medigus, ltd. israel) in patients with esophageal or extra-esophageal gastro-oesophageal reflux disease (gerd)-related symptoms. the end of the study will be at the end of the 6-year follow-up of the last patient enrolled. the study proposes the following objectives: * primary objective: to evaluate the efficacy of endoscopic fundoplication with muse for the treatment of gerd, through clinical experience, in terms of: * effect on gerd-health related quality of life (hrql) and reflux symptom index (rsi) questionnaire scores * effect on the use and dosage of proton pump inhibitors (ppi) * feasibility and safety of the endoluminal fundoplication procedure * secondary objective: to characterize the treated patient population (demographic and objective data) and to identify the successful predictors of the procedure. the study design includes the following phases: \*preliminary patient evaluation and verification of inclusion criteria through: upper gi endoscopy esophageal high-resolution manometry 24-hours esophageal ph-impedance off ppi ppi use gerd-hrql and rsi questionnaires scores off ppi * 6-month follow-up: upper gi endoscopy esophageal high-resolution manometry 24-hours esophageal ph-impedance off ppi ppi use gerd-hrql and rsi questionnaires scores off ppi * 12-months follow-up: upper gi endoscopy 24-hours esophageal ph-impedance off ppi ppi use gerd-hrql and rsi questionnaires scores off ppi * yearly clinical follow-up (up to 6 years): ppi use gerd-hrql and rsi questionnaires scores off ppi


Eligibility criteria:
inclusion criteria: * chronic (\> 6 months) gerd-related esophageal or extra-esophageal symptoms * endoscopic or ph-impedance evidence of gerd (esophagitis, barrett's esophagus, nerd, hypersensitive esophagus) * indication to surgical fundoplication * patients available for a long-term follow-up exclusion criteria: * hiatal hernia ≥ 3 cm * major esophageal motility disorder * esophageal stenosis * malignant neoplasia (except minor superficial skin neoplasm) * portal hypertension, bleeding disorders so to controindicate surgery, esophageal varices, stenosis or diverticula * previous cardiac, thoracic or upper gi surgery * bmi \>40 * pregnancy or breast feeding
effect of beet-root juice and pbm treatments on muscle fatigue

Conditions: Health Care Utilization; Healthy Aging

Summary: the goal of this randomized counterbalanced repeated measures study is to test beet-root juice supplementation and red light therapy augment forearm muscle endurance in apparently healthy older adults over 65 years of age. the main questions seek to answer the following question: does beet-root juice supplementation improve forearm muscle endurance compared to a placebo supplement? does red light therapy improve forearm muscle endurance compared to a sham light exposure? does beet-root juice supplementation in combination with red light therapy improve forearm muscle endurance compared to a placebo-sham light control?


Eligibility criteria:
inclusion criteria: * self-reports performing at least 30 minutes of light to moderate intensity physical activity 3 times per week for the last three months exclusion criteria: * currently smoke * have smoked within the last 6 months * are taking taking supplements known to increase blood nitrate levels * have a known kidney disease * have a known liver disease * have a known thyroid condition * have a known gastritis condition * are taking medications that are known to cause complications with nitrate supplementation * have known or reported joint pain within the dominant hand

Keywords: red light therapy forearm muscle endurance beet-root juice electromyography
pilot study of wearable artificial kidney

Conditions: Renal Failure

Summary: this is a pilot study of a wearable type of kidney dialysis machine to treat patients with chronic kidney disease.

this is a pilot study to evaluate the clearances, tolerability and safety of a wearable artificial kidney device for treating patients with chronic kidney failure.

Eligibility criteria:
inclusion criteria: * end stage renal failure * regular haemodialysis * cardiovascular stability * stable vascular access exclusion criteria: * allergy to heparin or ethylene oxide * recent cardiovascular or neurological event * unable to provide informed consent * age \< 18

Keywords: end stage renal failure dialysis wearable artificial kidney
a study of vivitrol in the prevention of re-arrest and re-incarceration

Conditions: Opioid Dependence

Summary: this phase 4 study will evaluate the feasibility of initiating subjects on vivitrol in prison and continuing vivitrol upon release into the community.

this is an open-label study with a pre-post design. pre-release opioid-dependent subjects from 4 baltimore, md area prisons (three for men and one for women) will receive 1 injection of vivitrol prior to release from prison and will be offered 6 monthly injections of vivitrol for 6 months post release. subjects will complete follow-up visits 1 and 2 months after the last vivitrol injection. subjects will be assessed at 10 time points, and adherence to vivitrol, both in prison and in the community, will be assessed.

Eligibility criteria:
inclusion criteria: * not currently addicted to opioids, but has a diagnosis of pre-incarceration opioid dependence * inmate at the metropolitan transition center (baltimore, md), maryland correctional institute for women (jessup, md), baltimore pre-release unit (baltimore, md), or jessup pre-release unit (jessup, md) and eligible for release within 30 days of screening * expressing a goal of opiate-free treatment upon release * currently opioid free * planning to live in the baltimore, md area for at least 8 months following prison release exclusion criteria: * pregnancy and/or breastfeeding * clinically significant active medical condition * active hepatitis * past or present history of an aids-indicator disease in subjects who are infected with hiv * any untreated or unstable psychiatric disorder(eg, bipolar with mania) * recent suicidal ideation * current chronic pain diagnosis for which opioids are prescribed * positive drug test for opioids * history of drug overdose within the past 3 years requiring inpatient hospitalization

Keywords: opioid dependence vivitrol criminal justice
the effect of dexmedetomidine on microcirculation in severe sepsis

Conditions: Severe Sepsis

Summary: despite early goal-directed maintenance of normal macrocirculation, the reduction of 60-day mortality of patients with severe sepsis and septic shock remained unsatisfied (56.9% to 44.3%). one of the major causes of high mortality is microcirculatory dysfunction. delayed diagnosis and treatment of microcirculatory dysfunction may cause tissue hypoperfusion and resulted in multiple organ dysfunction and death. dexmedetomidine is a highly selective α2-adrenoreceptor agonist which exhibits sedative and analgesic effects. recent studies suggest that dexmedetomidine also has anti-coagulation and anti-inflammatory effects, and it can reduce the mortality of endotoxemic rats and patients with severe sepsis. the investigators will conduct two animal studies and one clinical trial to investigate the effect of dexmedetomidine on microcirculatory dysfunction and organ injury in rat with endotoxemia and patients with severe sepsis and septic shock. sixty patients with severe sepsis and septic shock will be enrolled and randomized to control group or dexmedetomidine group. in the control group, the patients will be treated according to the clinical practice guideline. if sedation is required, non-dexmedetomidine sedative agents will be used. in the dexmedetomidine group, the patients will be treated according to the clinical practice guideline, and they will also receive continuous infusion of dexmedetomidine (infusion rate ranged from 0.1 to 0.7 mcg/kg/h) for 24 hours as needed. the sublingual microcirculation, serum level of endocan, ngal(neutrophil gelatinase-associated lipocalin), and bnp(b-type natriuretic peptide) will be examined at preset time points up to 24 hours. the vital signs, hemodynamic parameters, and survival of 28-day and 90-day will be recorded and analyzed.


Eligibility criteria:
inclusion criteria: * icu patients who require sedation * patients who have diagnosis of severe sepsis / septic shock * meet 2 or more of the 4 sirs criteria * with one organ dysfunction according the definition of surviving sepsis campaign exclusion criteria: * less than 20 y/o * refractory bradycardia (heart rate slower than 60 bpm despite of adequate treatment) * 2nd and 3rd degree of av-block * the onset of severe sepsis/septic shock is more than 24h before enrollment * apache ii \> 30 at enrollment * severe liver cirrhosis (child b or c) * new onset of myocardial infarction within 30 days or heart failure (nyha 4) * attend other trial in icu within one month * patient who is pregnant * receive organ transplantation within one year * expected survival is less than 30 days by attending physician * receive cardiopulmonary resuscitation within 4 weeks * patients who have signed consent of refusal of cardiopulmonary resuscitation and invasive therapy * have allergic history to dexmedetomidine * receive renal replacement therapy within 24 hours before enrollment * patient with hiv infection * non-native speaker * other factors not eligible for enrollment concerned by attending physician
promoting infant mental health in foster care

Conditions: Child Development; Child Behavior Disorders; Reactive Attachment Disorder

Summary: this study will evaluate the effectiveness of the promoting first relationships (pfr) program versus an early education support (ees) program in promoting infant well-being, preventing emotional and behavioral problems, countering developmental delay, and reducing placement instability in young foster care children.

infants who enter foster care are at risk for developing multiple social and emotional problems later in life. these behavioral issues often result in foster children being placed with multiple different families during their childhoods. in turn, an unstable family life can lead to serious conduct disorders and mental health problems. the infants' loss of their first attachment relationship heightens the risks for developing these problems, even if the quality of care was poor prior to removal. infants' reactions to this loss, combined with other vulnerabilities, complicate the development of new secure attachments to their foster care families. garnering a secure attachment relationship between foster parents and foster infants may reduce the infant's risk for developing problematic mental health and conduct issues. pfr is a family therapy intervention focused on aiding foster care parents to cultivate secure attachments with their foster infants. this study will evaluate the effectiveness of the pfr program versus an ees program in promoting attachment security and infant well-being, preventing emotional and behavioral problems, countering developmental delay, and reducing placement instability in young foster care children. participants in this single-blind study will be randomly assigned to receive either pfr or ees. both interventions will be administered by a trained staff member of a community agency. participants assigned to pfr will receive ten weekly home visits that will focus on promoting the development of a secure attachment between foster parents and infants. ees will consist of three monthly home visits, during which infants will be assessed and referred for additional care if necessary. ees participants will not receive any training. outcomes will be assessed at 1, 6, and 12 months post-intervention for all participants.

Eligibility criteria:
inclusion criteria: * transitioned into foster care, currently within foster care, or from foster care in past three months prior to study entry in pierce county, wa * primary caregiver is foster care provider, kin caregiver, or biological parent exclusion criteria: * foster care provider is not english-speaking

Keywords: infants toddlers attachment maltreatment foster care
delivery of soluble ferric pyrophosphate (sfp) via the dialysate to maintain iron balance in hemodialysis patients

Conditions: End Stage Renal Disease (ESRD)

Summary: in maintenance hemodialysis patients, regular administration of parenteral iron by addition of soluble ferric pyrophosphate (sfp) to the dialysate, when compared to conventional dialysate, is effective in preventing the development of iron deficiency, thereby maintaining hemoglobin level; is clinically safe and does not lead to oxidative stress or inflammation.


Eligibility criteria:
inclusion criteria:subjects with end stage renal disease undergoing maintenance hemodialysis three times a week. * subjects who have required iv iron at any time in the 2 months preceding enrollment. exclusion criteria: * subjects with absolute iron deficiency at the time of enrollment in hemodialysis subjects "absolute iron deficiency" * subjects with a current malignancy involving sites other than skin. * subjects with a history of drug or alcohol abuse within the last 6 months

Keywords: hemodialysis
increasing access to breast cancer screening among immigrants

Conditions: Cancer Screening

Summary: the investigators aim to test whether inviting immigrants to breast cancer screening with a letter in their mother tongue in addition to the standard letter in norwegian changes screening uptake in these immigrant groups, compared with a comparable group who receive the invitation in norwegian only,

women in selected immigrant groups according to birth country will be invited to screening and randomized in a 1:1 ratio to receive the screening invitation and information material 1) in the major official native language in the country the invitee is born in addition to norwegian (intervention group), or 2) only norwegian (control). the 13 selected countries of origin are poland, the philippines, pakistan, somalia and arabic speaking countries (iraq, syria, morocco, lebanon, algeria, egypt, palestine, sudan and tunisia). the five intervention languages will thus be polish, english, urdu, somali and arabic.

Eligibility criteria:
inclusion criteria: * invited to screening program during the study recruitment period (january 2021-june 2022) * the registered country of birth of the invitee is one of the following; poland, pakistan, philippines, somalia, iraq, syria, morocco, lebanon, algeria, egypt, palestine, sudan and tunisia exclusion criteria: * not reached with the screening invitation letter because of wrong address or similar

Keywords: cancer screening breast cancer non-native immigrant participation rate invitation information
fortified skimmed mother's milk in the management of chylothorax

Conditions: Chylous Pleural Effusion Following Cardiothoracic Surgery

Summary: the purpose of this study is to determine if the use of fortified skimmed mother's milk is a safe alternative to specialized formula in the treatment of chylothorax following cardiothoracic surgery.

a chylothorax is a collection of fluid around the lungs that can occur after cardiac surgery. the fluid contains chyle, a milky fluid consisting of fat droplets. the standard treatment is to feed an infant with a specialized low fat formula for up to 6 weeks until the chest has time to heal. this formula is generally not well tolerated and mother's of our patients have expressed a desire to continue using breast milk. a few case reports have been published, but there have not been any studies to date looking at this. data will be collected to include information about nutrition, weight gain, teaching needs, surgical, hospital, and discharge information.

Eligibility criteria:
inclusion criteria: * infant birth to 12 months of age * undergo cardiothoracic surgery * develop a chylous effusion * be a breastfed or formula fed infant exclusion criteria: * infant over 12 months of age * infant in state custody (foster care) * infant with milk protein allergy * infant born with congenital chylothorax * infant who develops chylothorax from other surgeries (non-cardiac