Kornimate/medical-research-clean huggingface dataset:
symptoms and quality of life of patients with suspected endometriosis

Conditions: Endometriosis; Surgery; Pain; Dysmenorrhea; Dyspareunia

Summary: all patients undergoing surgery due to suspected endometriosis in a previously selected 3-month period within the study period (between 12/2022 and 12/24) (each participating center will define the particular 3 months in question) will be asked to participate in this study. upon inclusion, patients will be asked to fill out questionnaires regarding endometriosis-associated symptoms as well as a detailed patient history. furthermore, patients will be asked to fill out 2 standardized questionnaires, one regarding quality of life (endometriosis-health profile-30) and one regarding sexual function (female sexual function index). six and 12 months after surgery, patients will again be asked to fill out these two standardized questionnaires as well as a questionnaire regarding postsurgical therapy and endometriosis-associated symptoms. the surgeon will be asked to fill out a form regarding the surgical procedure and possible surgical complications. the primary endpoints of this multicenter observational study are to prospectively examine: 1. if the individual symptoms correlate with the individual compartments of the surgical #enzian endometriosis classification 2. if the surgical intervention has an effect on the quality of life in relation to the individual #enzian compartments.


Eligibility criteria:
inclusion criteria: * planned surgery for suspected endometriosis * age between 18 and 50 * signed informed consent exclusion criteria: * menopause * current malignant disease
kurcosmart effects on people with type 2 dm

Conditions: Diabetes Mellitus, Type 2; Insulin Resistance; Inflammation; Body Weight

Summary: the investigators aim to evaluate the effect of curcumin and virgin coconut oil extract supplementation on people with type 2 dm, including blood glucose, hba1c levels, inflammation, body weight and insulin resistance evaluation

the investigators give kurcosmart supplementation aside from diabetes standard treatment to evaluate its benefits on people with type 2 dm, considering its effect on controlling fasting and prandial blood glucose, reducing hba1c level, controlling inflammation degree; and repairing insulin resistance

Eligibility criteria:
inclusion criteria: * confirmed type 2 dm * signing consent form exclusion criteria: * pregnant or breastfeeding * multiple organ failure * history of hypersensitivity reaction to curcumin and virgin coconut oil * cancer, renal insufficiency, hematological disease, acute heart failure, chronic liver disease

Keywords: curcumin coconut oil diabetes mellitus
methylprednisolone after split-course chemoradiotherapy for bulky local advanced none-small cell lung cancer

Conditions: Non-small Cell Lung Cancer

Summary: this phase ii randomized controlled study is to determine the efficacy of the preventively use of methylprednisolone after split-course chemoradiotherapy (ccrt) in locally advanced non-small cell lung cancer with bulky tumor.

this study is to determine the efficacy of the preventively use of methylprednisolone after split-course chemoradiotherapy(ccrt) in locally advanced non-small cell lung cancer with bulky tumor. all patients received four cycles of weekly docetaxel (25mg/㎡) and nedaplatin (25mg/㎡)(dp), each of 1 day's duration, combined with split-course thoracic radiotherapy, with one-month break. in the experimental arm, patients were treated with methylprednisolone after the first course of radiation, once a day, 32 milligram (mg) for 7 days, 24 mg for the next 7 days,then 16mg for 7 days, and 8 mg for the last 7 days. toxicities will be graded according to national cancer institute common terminology criteria for adverse events (ctcae) v. 4.0.

Eligibility criteria:
inclusion criteria: * pathologic confirmation of nsclc. * patients have measurable or evaluable lesions based on the response evaluation criteria in solid tumors (recist) criteria. * unresectable phase iiia(n2) and iiib lung cancer confirmed by pet/ct, ct or mri. * whole lung v20\>=35% when giving 60gy which is the minimum dose of radical irradiation. * eastern cooperative oncology group (ecog) performance status 0-1. * previously treated with chemotherapy or treatment-naive * no previous chest radiotherapy, immunotherapy or biotherapy * hemoglobin≥10 mg/dl, platelet≥100000/μl,absolute neutrophil count ≥1500/μl * serum creatinine ≤1.25 times the upper normal limit(unl), or creatinine clearance≥60 ml/min * bilirubin ≤1.5 times unl, ast（sgot）≤2.5 times unl ,alt（sgpt）≤2.5 times unl,alkaline phosphatase ≤5 times unl * fev1 \>0.8 l * cb6 within normal limits * patients and their family signed the informed consents exclusion criteria: * previous or recent another malignancy, except nonmelanoma skin cancer or cervical cancer in situ * contraindication for chemotherapy * malignant pleural or pericardial effusion. * women in pregnancy, lactation period, or no pregnancy test 14 days before the first dose * women who has the probability of pregnancy without contraception * tendency of hemorrhage * in other clinical trials within 30 days * addicted in drugs or alcohol, aids patients * uncontrollable seizure or psychotic patients without self-control ability * severe allergy or idiosyncrasy * not suitable for this study judged by researchers

Keywords: methylprednisolone split-course chemoradiotherapy radiation-induced pulmonary injury
effectiveness of a mobile texting intervention for people with serious mental illness

Conditions: Schizoaffective Disorder; Schizophrenia; Bipolar Disorder; Major Depressive Disorder

Summary: testing an mhealth mobile interventionist texting program on illness management.

the ultimate objective is to evaluate a validated mhealth intervention that can be realistically integrated into community mental health settings to increase the availability, reach, and broad impact of illness management approaches for people with serious mental illness (smi).

Eligibility criteria:
inclusion criteria: 1. chart diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, or major depressive disorder; 2. 18 years or older; 3. a rating of "3" or higher on one of three patient activation items; 4. ownership of a mobile phone with call/text plan (research staff will offer assistance in accessing the federal lifeline assistance program to people who do not have a mobile phone and/or call/text plan if they are otherwise eligible); 5. receiving community based treatment services. exclusion criteria: 1. hearing, vision, or motor impairment that make it impossible to operate a mobile phone (determined using the individual's device for screening); 2. english reading level below 4th grade (determined using the reading section from the wide range achievement test - 4th edition (wrat-4).

Keywords: mhealth texting intervention mobile health mobile mental health
examination of the relationship between foot - body posture and balance and gait in duchenne muscular dystrophy

Conditions: Foot Posture; Balance; Gait Disorders, Neurologic; Body Posture

Summary: foot and body postures of patients with dmd will be evaluated. foot structure characteristics such as foot length, metatarsal width, calcaneal valgus angle will be calculated for the foot posture. also, the foot posture index (fpi-6) scale will be used. the body posture will be evaluated with the new york posture scale. many gait characteristics such as step length, cadence, support surface of the patients will be determined with gaitrite instrumented walkway. patients' balance assessment will be evaluated with bertec balance advantage. the statistical analysis method will determine the relationship between foot and body posture and gait and balance.


Eligibility criteria:
inclusion criteria: 1. to be between 5-13 years old 2. being at level i or ii according to brooke lower extremity functional classification scale 3. in the balance assessment, there should be at least 90 degrees of joint range of motion in the ankle to provide base contact on the force platform. 4. agree to participate in the research voluntarily exclusion criteria: 1. having serious mental and psychological problems, 2. failure to cooperate adequately with the physiotherapist making the evaluations, 3. severe contracture in lower extremities, 4. any injury and / or surgery of the lower extremities in the past 6 months.
study of anti-cd22 car nk cells in relapsed and refractory b cell lymphoma

Conditions: Refractory B-Cell Lymphoma

Summary: this is a single-centre, single-arm and open-label study to investigate the safety and efficacy of anti cd22 car nk cells in patients with relapsed refractory b cell lymphoma.


Eligibility criteria:
inclusion criteria: 1. cd19 (+) b cell lymphoma confirmed by pathological immunohistochemistry or flow cytometry 2. previously accepted ≥ first-line regimen chemotherapy 3. unconditional acceptance of hematopoietic stem cell transplantation or recurrence after hematopoietic stem cell transplantation 4. over 18 years old and under 70 years old 5. the expected survival period is more than 3 months. 6. ecog≤2 7. important organ function is satisfied: cardiac ultrasound indicates cardiac ejection fraction ≥50%, no abnormal electrocardiogram; blood oxygen saturation ≥90%; creatinine clearance ≥40 ml/min; alt and ast≤3 times normal range, total bilirubin ≤ 2.0 mg / dl; 8. blood routine: hgb≥80 g/l, anc≥1×109/l, plt≥50×109/l; 9. the pregnancy test for women of childbearing age must be negative; both men and women must agree to use effective contraception during the treatment period and for the following 1 year. 10. measurable target lesion exclusion criteria: 1. patients with extra-medullary relapse 2. burkitt's lymphoma/leukemia 3. previously received gene product treatment, anti-cd19/anti-cd3 treatment, or any anti-cd19 treatment; 4. liver and kidney function: total bilirubin \> 2 × uln (gilbert syndrome \> 3 × uln) aspartate aminotransferase (ast) and alanine aminotransferase (alt) \> 3 × uln serum creatinine clearance \>60 ml/min 5. serological examination: absolute neutrophil count (anc) \<0.75×109/l platelet count (plt) \<50×109/l 6. active hepatitis b (hbv-dna \> 1000 copies / ml), hepatitis c, or uncontrolled infection 7. gvhd ≥ 2 or anti-gvhd treatment 8. im19 car nk cells received allogeneic cell therapy within 6 weeks before infusion, such as donor lymphocyte infusion; 9. subject received the most recent treatment (release, chemotherapy, or other) less than 4 weeks 10. active cns disease (tumor cells in csf, but \< 5 wbcs/ml can be included); 11. intracranial hypertension or unconsciousness; respiratory failure; diffuse vascular internal coagulation 12. creatinine \> 1.5 times normal upper limit or alt / ast \> 3 times normal upper limit or bilirubin \> 2 times normal upper limit 13. new york heart association (nyha) graded above or above 14. uncontrollable diabetes 15. suffering from other uncontrolled diseases, the researchers believe that it is not suitable for joining 16. any situation that the investigator believes may increase the risk of the subject or interfere with the test results
a clinical investigation of the discovery™ elbow system

Conditions: Osteoarthritis; Rheumatoid Arthritis; Avascular Necrosis; Humeral Fractures

Summary: the purpose of this study is to perform a five-year, multi-center prospective evaluation of the discovery™ elbow system for outcome and durability. relief of pain and restoration of function will determine long-term clinical outcome while durability will be measured by the absence of revisions.

patient follow-up outcomes measured by the ases score, radiographs and adverse events/revisions.

Eligibility criteria:
inclusion criteria: * non-inflammatory degenerative joint disease including osteoarthritis and avascular necrosis. * inflammatory arthritis * revision where other devices or treatments have failed * correction of functional deformity * treatment of acute fractures or non-union about the elbow patient selection factors to be considered include: * need to obtain pain relief and improve function. * ability and willingness to follow instructions including control of weight and activity levels. * patients who are able and willing to return for follow-up evaluations. * patients with a good nutritional state. * patients with full skeletal maturity. * patients of all races and gender. * patients who are able to follow care instructions. exclusion criteria: * patients less than 18 years. * patients with marked bone loss which would preclude proper fixation of the prosthesis. * metabolic disorders, which may impair bone formation. * patients who are pregnant. * patients with an active or suspected infection in or around the elbow or distant foci of infections, which may spread to the implant site. * patients with a highly communicable disease or diseases that may limit follow-up (e.g. immuno-compromised conditions, hepatitis, active tuberculosis, neoplastic disease, etc.). * patients unwilling or unable to comply with a rehabilitation program for elbow replacement or who indicate difficulty or inability to return for follow-up visits prescribed by the study protocol. * patients who qualify for inclusion in the study, but refuse consent to participate in the study.

Keywords: total elbow arthroplasty total elbow replacement osteoarthritis elbow arthritis
prandial insulin dosing in hospitalized patients

Conditions: Diabetes; Admitting Hospital; Non-critically Ill

Summary: the purpose of this study is to determine whether mealtime insulin results in better control of blood sugar than a fixed meal dose in hospitalized patients.

the purpose of this study is to determine whether mealtime insulin, dosed to match the intake of carbohydrates (starches or sugars) results in better control of blood sugar than a fixed meal dose in hospitalized patients.

Eligibility criteria:
inclusion criteria: * general medical or minor surgical hospitalized patients * type 2 diabetes * blood glucose 150-400 on at least 2 occasions within 24 hours or requiring at least 20 units of insulin/day in the 24 hours prior to enrollment exclusion criteria: * • major surgery, occurring within the previous 2 weeks or planned within 72 hours of study entry, including cardiothoracic, neurosurgical, and open intra-abdominal procedures (in particular, any surgery lasting over 2 hours). * patients receiving glucocorticoids, total parental nutrition (tpn), or tube feeds. * pregnancy (glucose targets differ in pregnancy). premenopausal women not on pharmacologic contraceptives, inrauterine device (iud), or surgical menopause will undergo pregnancy testing. * patients currently on iv insulin (must wait to enroll) or with planned surgical procedures in the next 72 hours for whom intravenous insulin will be likely * prolonged (\>24 hour) strict nil per os (npo-nothing by mouth) status (eg. small bowl obstruction). liquid or modified consistency diets are acceptable. * patients for whom expected length of stay will be less than 48 hours * patients using subcutaneous insulin pumps * diabetic ketoacidosis * end-stage renal disease on dialysis * end-stage liver disease with cirrhosis * mental conditions precluding informed consent * potentially sensitive admissions: prisoners, hiv, suicidality * unable to give consent in english

Keywords: diabetes glucose hospital
perioperative factors impacting surgical risk and outcomes in children

Conditions: Surgery; Orthopedic Disorder

Summary: this prospective study will measure various factors in children coming in for ambulatory surgery and attempt to create a scoring system that would be able to predict post-operative outcomes.


Eligibility criteria:
inclusion criteria: * pediatric patients aged 6-18 years old having ambulatory orthopedic surgery with or without planned postoperative admission. * patients need to be cooperative to under spirometry testing and reaction time measurement. if unable to perform, we will assess why they were not able (non-cooperative, inability, etc) exclusion criteria: * spinal fusion
diagnosis and history study of patients with different neurological conditions

Conditions: Nervous System Disease; Healthy Volunteer

Summary: this protocol is a screening and natural history protocol, which allows for evaluation of patients and families where neurological conditions are present for enrollment into other studies and will also be used to screen healthy volunteers to create a pool of potential future hv matches for hmcs protocols. through diagnostic evaluations, data will be collected for research use in this study.

this protocol is a screening and natural history protocol, which allows for evaluation of patients and families where neurological conditions are present for enrollment into other studies and will also be used to screen healthy volunteers to create a pool of potential future hv matches for hmcs protocols. through diagnostic evaluations, data will be collected for research use in this study.

Eligibility criteria:
* inclusion criteria: * patients with neurological disorders and subjects with a family history of neurological conditions or * healthy volunteers: people age 18 or older who are generally in good health. exclusion criteria: * patients \<2 years old. * employees of hmcs in ninds.

Keywords: healthy volunteer nervous system disease natural history
cervical sensorimotor control training in chronic neck pain

Conditions: Nonspecific Chronic Neck Pain

Summary: impaired cervical joint position sense is associated with neck pain. this study will determine the effects of sensorimotor control training exercises on cervical joint position, pain, rom and function in nonspecific chronic neck pain. there will be two groups ; experimental and control. half of study group will receive cervical sensorimotor control training exercises and half of study group will receive conventional physiotherapy protocol.

the study is randomized control trail , which is being conducted in physical therapy out patient department of pakistan railway hospital (april 2019-july 2019) . sample size of 18 individual was calculated using epitool with 95% confidence interval (ci), and power 80%. individual will be screened out according to inclusion criteria. individuals will be allocated randomly into two groups , 9 in cervical sensori-motor training group and 9 in conventional physiotherapy protocol group by sealed envelope method. both groups will receive conventional physiotherapy protocol (hot pack, stretching exercises and strengthening exercises) for neck pain in common and the experimental group will receive cervical sensorimotor control training in addition to conventional protocol. assessment will be done on baseline and 6th week. data will be analysed on spss version 21.

Eligibility criteria:
inclusion criteria: * age between 20 to 50 years * non specific neck pain * insidious neck pain for at least 3 month * average pain intensity over the past week \>4 on numeric pain rating scale(nprs) exclusion criteria: * previous history of neck and head trauma or surgery * inflammatory joint disease * systemic conditions * cognitive impairment * taking four or more medications

Keywords: cervical pain kinesthesis
gemeprost versus dinoprostone in first trimester miscarriages

Conditions: Missed Abortion; Medical; Abortion, Fetus; Incomplete Abortion

Summary: comparison between gemeprost and dinoprostone to evacuate first trimester miscarriages.

women who are diagnosed with first trimester missed miscarriages are invited to participate in the study. they will be randomised to either gemeprost or dinoprostone.

Eligibility criteria:
inclusion criteria: * missed miscarriages * incomplete miscarriages * first trimester exclusion criteria: * coagulopathy * rhesus negative * suspected ectopic pregnancy or pregnancy of unknown location * on anticoagulation drug * septic miscarriages * hemodynamically unstable

Keywords: miscarriages first trimester medical treatment
explanted lung tissues with pulmonary fibrosis

Conditions: Pulmonary Fibrosis

Summary: the goal of this study is to use the tissues from the explanted lungs in order to better study the cause of pulmonary fibrosis at a cellular level.

pulmonary fibrosis involves scarring of the lung. gradually, the air sacs of the lungs become replaced by fibrotic tissue. the most current thinking is that the fibrotic process is a reaction to tiny injury to the lung. when the scar forms, the tissue becomes thicker causing a permanent loss of the tissue's ability to carry oxygen into the bloodstream. we need to obtain lung tissue from patients without pulmonary fibrosis and compare it to lung tissue from patients with pulmonary fibrosis.

Eligibility criteria:
inclusion criteria: * all patients awaiting lung transplant exclusion criteria: * all who will not give consent

Keywords: explanted lungs pulmonary fibrosis
effect of omega-3 fatty acids on insulin sensitivity in chinese type 2 diabetic patients

Conditions: Type 2 Diabetes; Insulin Resistance

Summary: this study is to examine the change of fasting insulin, glucose, insulin sensitivity and related traits in response to the six month treatment of omega-3 fatty acids, including fish oil and flaxseed oil, in chinese type 2 diabetic patients. corn oil, rich in omega-6 fatty acids, will be selected as a controlled oil. the investigators hypothesize that omega-3 fatty acids could improve insulin sensitivity and glucose metabolism in chinese type 2 diabetic patients.

the insulin resistance will be estimated by a homeostatic model assessment model of insulin resistance (homa-ir)

Eligibility criteria:
inclusion criteria: 1. fasting glucose \> 7.0 or have diabetes medication; 2. male, 35-80 years; female, postmenopausal to 80 years; 3. agree to participant in the trial. exclusion criteria: 1. deny to sign the informed consent; 2. type 1 diabetes; 3. family history of hypertriglyceridemia or fasting triglyceride\>4.56 mmol/l; 4. have severe liver disease, kidney disease or cancer; 5. participating in the other clinical trial within 30 days; 6. other diseases or conditions, for which the doctor of the patients do not agree his or her participating.

Keywords: omega-3 fatty acids randomized controlled trial