Kornimate/medical-research-clean huggingface dataset:
prognostic value of chest ultrasound (lung ultrasound score) in covid-19 pneumonia patients

Conditions: COVID-19 Pneumonia

Summary: this study aims to 1. to study the prognostic value of lus in covid-19 patients. 2. to assess the relation between lung ultrasonography score and disease severity in covid-19 patients. 3. to assess the relation between lung ultrasonography score and mortality in covid-19 patients.

at the end of 2019, the covid-19 pandemic broke out in wuhan, china, and within few months -in march 2020- it was declared a pandemic by the who. as of september 15th ,2021, there have been 226,844,344 confirmed cases of covid-19, including 4,666,334 deaths, reported to who (1). due to the prevalence of covid-19 and the financial burden it puts on the healthcare system, the use of a simple, affordable and reliable imaging modality was necessary. the main idea in this research will be evaluating the value of lung ultrasonography score in predicting the prognosis of patients with covid-19 pneumonia and investigate the presence of a relation between the lung ultrasonography score and patients' prognosis and mortality (2). * currently, lung ultrasound had sensitivity 86%, specificity 71.6%, npv 81.7%, and ppv 77.7%. the lus had an area under the curve of 0.84 (95% ci 0.78, 0.90). when including examinations visualizing twelve lung areas, lung us had sensitivity 90.9% and specificity 75.6%, with npv 87.2% and ppv 82.0% and an area under the curve of 0.89 (95% ci 0.83, 0.96). (3). * in covid-19 patients admitted in ed, lus was a good predictor of death, icu admission, and endotracheal intubation. * our main strategy will be enrolling patients admitted to the chest department's isolation unit, conduct clinical examination, laboratory investigations and imaging and conduct chest ultrasonography and calculate the lung ultrasonography score of the patients and create a correlation between the lung ultrasonography score and their prognosis and mortality.

Eligibility criteria:
inclusion criteria: * age \> 18. * all confirmed covid-19 patients by pcr or highly suspected patients admitted to the chest department's isolation unit during the duration of the study. exclusion criteria: * age \< 18. * heart failure * chronic lung diseases with similar ultrasonographic findings to covid-19 (ild, bronchiectasis, old t.b).
a study to assess the pharmacodynamics of vk0214 in male subjects with amn

Conditions: Adrenomyeloneuropathy Form (AMN) of X-linked Adrenoleukodystrophy (X-ALD)

Summary: subjects will be administered multiple doses of vk0214 in a cohort dose escalation process. a total of up to 36 subjects will be enrolled in the study, into one of three dose cohorts. for each cohort, up to 12 subjects will be randomized to receive vk0214 or placebo in a 3:1 ratio so that there will be a total of up to 9 subjects for each of the active doses and up to 3 subjects dosed with placebo in each cohort.

the first part of vk0214-102 will include the first 2 dose cohorts and placebo, which will be dosed in parallel (up to n=24). the first 2 doses used in these cohorts will be 20 mg qd and 40 mg qd for 28 days. a dose level review team (dlrt) meeting will be held at the end of the first 2 parallel doses. the dlrt will review safety, tolerability, and preliminary efficacy data from cohort 1 and 2. if the data analyzed show that the first 2 doses are safe and well tolerated the dlrt may make a recommendation for proceeding to commence dosing in the third dose cohort. based upon outcomes in cohorts 1 and 2, the sponsor may decide to include a third dose cohort. before screening may be initiated in cohort 3, data to support dosing in this cohort will be submitted to the fda, together with the amended protocol and the dosing recommendation of the dlrt.

Eligibility criteria:
inclusion criteria: * provide a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the study and is willing and able to participate. * have diagnosis of x-linked adrenoleukodystrophy (x-ald) by genetic testing and elevated vlcfas. * present clinical features of amn, or adrenal insufficiency. * subjects must be 18 years of age and older. exclusion criteria: * have the cerebral form of x-ald, based on medical records, or based on mri performed within the last 12 months or mri at screening * have been treated with any drug targeting trβ or with any drug being tested as therapy for x-ald amn form within the past 30 days before screening * history or presence of clinically significant acute or unstable hepatic, renal, gastrointestinal, pulmonary, immunological, endocrine, diabetes, hematological or oncological that in the opinion of the investigator would pose a significant risk for the subject * subject has untreated primary adrenal insufficiency based on morning plasma cortisol and acth at screening * lorenzo's oil. currently taking lorenzo's oil or erucic acid containing product, or other lipid lowering agent known to effect vlcfa levels

Keywords: amn, xald
exercise in the physiotherapy management of shoulder impingement

Conditions: Subacromial Impingement Syndrome

Summary: the purpose of this trial is to investigate the effectiveness of an evidence based exercise program for shoulder impingement. approximately 1% of adults consult their general practitioner (gp) with shoulder pain each year, making it the third most common reason for musculoskeletal gp consultations in the uk. a further 50% of these patients are diagnosed with subacromial impingement syndrome (sais) (shoulder impingement syndrome) and commonly referred for physiotherapy treatment. this trial aims to compare the effectiveness of an evidence based exercise protocol with usual physiotherapy care.

physiotherapy management of shoulder impingement frequently involves exercise, however there is little evidence underpinning exercise prescription and outcomes are poor. few trials have investigated which muscles should be targeted and how they should be strengthened with respect to the mode, frequency, duration, intensity and progression. this is a randomized controlled trial(rct) investigating the effectiveness of an evidence based exercise program for shoulder impingement. this research may have an impact on how physiotherapists provide exercise programs to patients with shoulder impingement.

Eligibility criteria:
inclusion criteria: * patients must be aged 18 years and older. * shoulder pain of at least 3/10 in severity that has been diagnosed by a consultant rheumatologist, orthopaedic surgeon or general practitioner within the past 12 months. * positive hawkins-kennedy test. * positive on testing either supraspinatus (empty can test) or infraspinatus (resisted external rotation in neutral). exclusion criteria: * acute traumatic conditions. * evidence of rotator cuff tear (positive drop arm test) or any other shoulder joint pathology (e.g. adhesive capsulitis, labral tears). * a history of fractures of the upper arm, shoulder or clavicle within the past two years. * a history of dislocation of the shoulder within the previous two years. * postoperative conditions involving the upper arm, shoulder or clavicle. * inflammatory or systemic diseases. * current signs and symptoms of acute nerve root pain arising from the cervical or upper thoracic spine. * previous physiotherapy for the same condition involving an exercise regime. * previous corticosteroid injection of the affected shoulder within the past 6 months. * unwilling participant.

Keywords: subacromial impingement syndrome rotator cuff exercise physiotherapy
the effect of foot massage with roles on cancer patients

Conditions: Breast Neoplasms; Over Cancer; Foot Massage

Summary: it was aimed to examine the roles in the management of treatment-related peripheral neuropathy in cancer patients receiving taxane-based chemotherapy and the effect of foot massage on neuropathy and quality of life.

intervention phase of the research; 1. patient information about neuropathy caused by chemotherapy and its management, 2. teaching the role application to the patient, 3. application process 4. it will be carried out in 4 steps, including patient monitoring via telemonitoring.

Eligibility criteria:
inclusion criteria: * being registered in the medical oncology outpatient clinic of selçuk university faculty of medicine hospital * completed standard taxane-based chemotherapy treatment protocol for breast and ovarian cancer * karnofsky performance scale being 80 and above (performance scale of cancer patients) * being 18 years or older * having received at least 3 cycles of taxane-based treatment * presence of grade 2 or higher peripheral neuropathy * being conscious and cooperative * verbal and written approval to participate in the study after an explanation about the study is made. exclusion criteria: * previous skin sensitivity on hands and feet * refused to participate in the study after making a statement about the study * development of peripheral neuropathy due to reasons other than chemotherapy \[tumor compression, nutritional disorders, infections or major systemic disease (diabetes mellitus, etc.)\] * bone, spine metastasis or malignancy * having mental and psychic problems that would prevent him from taking part in the research.
the effect of manual therapy on psychological factors and quality of life in lumbal disc herniation patients

Conditions: Intervertebral Disc Displacement; Lumbar Disc Herniation; Psychological; Quality of Life

Summary: when the literature is examined, there are studies examining the relationship between low back pain and anxiety depression, quality of life and ldh in patients with lumbar disc herniation. there are many studies on the clinical use of manual therapy methods in ldh. most of these studies examine the effect of manual therapy on pain and functional level. however, there are hardly any studies examining the effect of manual therapy on quality of life and psychological factors in ldh patients. the aim of our study is to examine the effect of mobilization, which is a manual therapy application, on psychological factors (kinesiophobia, pain catastrophic thought, anxiety and depression) and quality of life in ldh patients.

there are various treatment options that can be applied to patients with lumbar disc herniation (ldh). these are basically divided into 2 categories: surgical and conservative treatment. conservative treatment methods in the treatment of ldh aim to prevent the disease from transitioning to interventional methods and / or surgical treatment and to improve the complaints that negatively affect the quality of life. conservative treatment; it includes informing the patient, bed rest, drug treatments, exercise, thermotherapy, electrotherapy, traction, orthoses, back school and manual therapy applications. manual therapy; it is used to reduce pain, provide joint and tissue mobility, inhibit sympathetic reflex activity, normalize muscle tone and dissolve adhesions. manual therapy is the manual treatment of the spine with two different applications such as manipulation and mobilization. the clinical effects of manual therapy in ldh patients were examined. the aim of this study was to investigate the effect of manual therapy on psychological factors and quality of life in patients with lumbar disc herniation.

Eligibility criteria:
inclusion criteria: * it was determined as being diagnosed with ldh by mr by a physical therapy physician * having pain of at least 3 levels or more according to the visual analogue scale * being between the ages of 18-65. exclusion criteria: * history of spinal surgery * history of autoimmune disease (ankylosing spondylitis, rheumatoid arthritis or other) * spondylolysis and spondylolisthesis * spinal fracture * heart pathology * history of stroke, * cauda equina syndrome * continuous use of pain medication * spinal inflammation,

Keywords: lumbar disc herniation manual therapy kinesiophobia anxiety and depression pain catastrophe
posoleucel (alvr105) for the treatment of adenovirus infection in pediatric and adult participants receiving standard of care following allogeneic hematopoietic cell transplantation

Conditions: Adenovirus Infection

Summary: this study will assess the safety and efficacy of posoleucel for the treatment of adenovirus (adv) infection in pediatric and adult allo-hct recipients receiving standard of care (soc).

during the period of immune recovery after allogeneic hematopoietic cell transplant (allo-hct), viral infections and reactivations, including those with adv, are an important cause of morbidity and mortality. progression to adv disease is associated with significant morbidity and mortality rates. this phase 3, multicenter, randomized, double-blind, placebo-controlled study will assess the safety and efficacy of posoleucel for the treatment of adv infection in pediatric and adult allo-hct recipients receiving soc.

Eligibility criteria:
inclusion criteria: * undergone allogeneic cell transplantation ≥21 days prior to dosing * meet one of the below criteria: 1. adv viremia dna ≥10,000 copies/ml, or 2. adv viremia dna results of ≥1,000 copies/ml, and 1. has absolute lymphocyte count \<180/mm3, or 2. has received t cell depletion or 3. had a cord blood transplant. exclusion criteria: * grade 3 or higher acute gvhd * ongoing therapy with high-dose systemic corticosteroids * uncontrolled viral (other than adv), bacterial, or fungal infection(s) * pregnant or lactating female unwilling to discontinue nursing prior to randomization * history of severe prior reactions to blood product transfusions note: other protocol-defined inclusion/exclusion criterion may apply.

Keywords: allogeneic hematopoietic cell transplant adenoviremia adenovirus stem cell transplant posoleucel alvr105 bone marrow transplant
clinical trial to evaluate the safety and efficacy of scarclinic™ thin in surgical scars

Conditions: Hypertrophic Surgical Scar

Summary: compare the efficacy and safety of scarclinic™thin and scarclinic™ normal for the treatment of surgical scars. participant: 40 treatment period : 3 months medical device: scarclinic™thin , scarclinic™ normal randomization: table of random number

for evaluating the efficacy * the investigator check vancouver scar scale at 1 and 3 month after application to evaluate vascularity, pigmentation, elasticity, height, pain and itchiness * the participant filled out survey included questions regarding convenience in use at 1 and 3 month after application.

Eligibility criteria:
inclusion criteria: * patient who aged more than 18 years and less 55 years * patient who has a surgical scar that is not over 3 months after the surgery * patient who sign informed consent form for the study exclusion criteria: * need wound dressing for exudate * wound infection * general malaise * history of mental disorders * taking anticancer drugs or antiphlogistics or steroid

Keywords: hypertropic scar, vancouver scar scale, silicon gel sheet
self-control in bulimia nervosa

Conditions: Bulimia Nervosa

Summary: this study examines the influence of acute fasting and eating on self-control in adult females with and without bulimia nervosa (bn). specifically, the study team is investigating whether differences in behavior and brain activation in response to computer tasks after fasting and after eating a meal could help to explain the symptoms of bulimia nervosa. data will be collected using questionnaires and a technology called magnetic resonance imaging (mri).

treatment-resistant binge eating and purging may be perpetuated by self-control deficits linked to reduced activation in frontostriatal circuits. to date, however, neurocognitive studies of bn have not assessed the dynamic computational processes underlying inhibition or considered the fact that individuals with bn oscillate between two extremes-under-controlled and over-controlled intake. the proposed study combines neuroimaging with computational modeling to investigate the influences of acute fasting and eating (i.e., metabolic states) on how the brains of women with bulimia nervosa (bn) adaptively prepare for and exert inhibitory control. more specifically, the study has the following main objectives: 1) to determine whether eating and fasting affect adaptive inhibitory control and related frontostriatal activation abnormally in bn; 2) to identify associations of bn severity with state-specific frontostriatal activation and behavior.

Eligibility criteria:
inclusion criteria: * female * aged 18 to 35 years * currently between 85 and 130% of the expected weight for height * right-handed * english-speaking additional inclusion criteria for women with bulimia nervosa: ° meet dsm-5 criteria for bulimia nervosa exclusion criteria: * medical instability * ongoing medical treatment, medical condition, or psychiatric disorder that may interfere with study variables or participation * shift work * pregnancy, planned pregnancy, or lactation during the study period * allergy to any of the ingredients in or unwillingness to consume the standardized meal or unwillingness to drink water during the fasting period * any contraindication for fmri

Keywords: bulimia nervosa binge eating purging fasting eating disorder control
interstitial lung abnormalities in renal transplant recipients

Conditions: Renal Transplantation; Kidney-pancreas Transplantation

Summary: immunosuppressive drugs such as tacrolimus, cyclosporine, mycophenolate mofetil, sirolimus and everolimus may have toxic pulmonary effects, particularly interstitial alterations. the aim of the present study is to explore the presence of subclinical interstitial lung abnormalities in stable renal transplant recipients taking the different immunosuppressive drugs used as maintenance therapy for renal transplantation.

prospective, cross-sectional study examining the high-resolution ct scans obtained in 63 stable renal transplant recipients taking immunosuppressive treatment for at least 24 months. the findings in patients taking the newer immunosuppressive drugs (mycophenolic acid, sirolimus and everolimus) are compared with those of the patients treated in the traditional way (cyclosporine, tacrolimus, azathioprine). all patients undergo high-resolution ct scanning. eligibility criteria: recipients of kidney or kidney-pancreas transplant, on immunosuppressive therapy for at least 24 months, with stable renal function and absence of any overt lung disease or lung alterations induced by other drugs, systemic diseases or occupational exposure to fibrogenic agents.

Eligibility criteria:
inclusion criteria: * renal transplant patients with stable renal function taking immunosuppressive therapy for at least 24 months and providing written informed consent to participate to the study exclusion criteria: * overt lung disorders, lung toxicity due to other drugs or occupational exposure to lung-toxic agents * systemic connective tissue disorders or systemic vasculitis

Keywords: interstitial lung disease immunosuppressive therapy renal transplant
accuracy of multi-organ ultrasound for the diagnosis of pulmonary embolism

Conditions: Pulmonary Embolism

Summary: patients with suspected pulmonary embolism (pe) and a high clinical probability or a high d-dimer level should undergo a second level diagnostic test such as multidetector computed tomography angiography (mctpa). unfortunately mctpa involves radiation exposure, is expensive, is not feasible in unstable patients and has contraindications. ultrasound (us) is safe and rapidly available even in unstable patients. many authors evaluated the diagnostic role of compression ultrasound scan (cus) for detecting limbs deep vein thrombosis (dvt), transthoracic echocardiography (tte) for detecting right ventricular dysfunction (rvd) or thoracic ultrasound (tus) for detecting subpleural infarcts in patients with suspected pe. no previous studies have investigated the diagnostic accuracy of cus, tte and tus combined (multiorgan us) for the diagnosis of pe. this study evaluates the diagnostic accuracy of multiorgan us. methods. consecutive patients that underwent mctpa in the emergency department for clinical suspicion of pe and with a simplified well's score\>4 (pe likely) or with a d-dimer value ≥500ng/ml were enrolled in the study. mctpa was considered the gold standard for pe diagnosis. a multiorgan us was performed by an emergency physician sonographer before mctpa. pe was considered echographically present if cus was positive for dvt or tte was positive for rvd or at least one pulmonary subpleural infarct was detected with tus. the accuracy of the single and multiorgan us was calculated.


Eligibility criteria:
inclusion criteria: * patients with clinical suspected pulmonary embolism * simplified well's score\>4 (pe likely) or d-dimer value ≥500ng/ml * patients that undergo mctpa in the emergency department for suspected pulmonary embolism exclusion criteria: * refused consent * less than 18 years old * not possible to perform ultrasound scan within 3 hours before mctpa

Keywords: pulmonary embolism diagnosis ultrasound
a pilot study of hemoporfin pdt in children with port-wine stain

Conditions: Port-wine Stain

Summary: this pilot study aims to evaluate the efficacy and safety of hemoporfin photodynamic therapy (pdt) with different light doses for port-wine stain (pws） in 7-14 years old children. the population pharmacokinetics of hemoporfin in children will be investigated as well.


Eligibility criteria:
inclusion criteria: * children with clinical diagnosis of pws； * age range: 7 to 14 years-old； * voluntarily participated and written informed consent signed exclusion criteria: * therapy area located outside of head and neck; * other skin diseases that might interfere with the efficacy evaluation; * therapy area was previously received isotope or pdt or other treatment which might interfere with the efficacy evaluation; * allergy to porphyrins and analogues; photosensitivity; porphyria; allergic constitution; * scar diathesis; * immunocompromised conditions; * electrocardiographic abnormalities or organic heart diseases; * coagulation disorders; * hepatic or renal functions abnormal (alanine aminotransferase or aspartate transaminase or total bilirubin \> 1.5 upper limit of normal \[uln\], or serum creatinine or blood urea nitrogen \> 1.5 uln); * psychiatric diseases; severe endocrinopathies; * previous therapy of pws within the last 4 weeks; * participation in any clinical studies within the last 4 weeks; * be judged not suitable to participate the study by the investigators
chronic effects of two aerobic-training models performed in water and on dry land in patients with type 2 diabetes mellitus (t2dm).

Conditions: Diabetes Mellitus, Type 2

Summary: the aim of this study was to analyse the acute and chronic effects of two aerobic-training models performed in water and on dry land on cardiorespiratory, functional, metabolic, hormonal and quality-of-life parameters in patients with type 2 diabetes mellitus (t2dm).


Eligibility criteria:
inclusion criteria: the clinical diagnosis of type 2 diabetes mellitus. not be performing regular and systematic physical exercise for at least three months. exclusion criteria: uncontrolled hypertension. autonomic neuropathy. severe peripheral neuropathy. proliferative diabetic retinopathy. severe nonproliferative diabetic retinopathy. uncompensated heart failure. peripheral amputations. chronic renal failure (gfr by mdrd \<30). muscle or joint injury that prevents physical exercises.

Keywords: aquatic exercises; deep water running; diabetes; blood glucose; inflammation.