Kornimate/medical-research-clean huggingface dataset:
low speed drilling versus conventional drilling technique on crestal bone level in maxilla.(group b ) a randomized controlled clinical trial

Conditions: Bone Resorption

Summary: 20 patients were selected requiring implant placement and divided randomly into two groups (10 in each group) * for the study group, starter drill is used to locate the point of insertion as planned then pilot drill is also used to the full desired working length after that all other sequential drills are used at a low speed (50-70 rpm) without irrigation . * in the study group: implant will be inserted in the low speed osteotomy site. * in the control group: implants will be inserted in the conventional prepared osteotomy site. * for both groups there is no surgical guide used. * the flap will then be copiously irrigated with saline in preparation for closure. * the flap will then be closed using interrupted 4/0 resorbable sutures.


Eligibility criteria:
inclusion criteria: * patients restoring missing maxillary teeth with implant placement. * both sexes. * age: 25-45 * mesio-distal dimensions: not less than 6 mm * bone height: not less than 12 mm * bucco-lingual dimensions: not less than 8mm * all measures will be assessed using cbct. exclusion criteria: * sites needing bone grafting or augmentation. * heavy smokers more than 20 cigarettes per day. * patients with systemic disease that may affect normal healing.
two weeks of low molecular weight heparin for distal vein thrombosis

Conditions: Venous Thrombosis; Pulmonary Embolism

Summary: the purpose of this study is to determine whether a limited duration of treatment (two weeks of low molecular weight treatment) is a safe and effective treatment for distal deep vein thrombosis of the lower limb.

approximately 50% of symptomatic episodes of deep vein thrombosis (dvt) will be confined to the calf veins (distal dvt). the proportion of distal dvt that propagate to the proximal veins, increasing the risk of pulmonary embolism, is not known. the best treatment of isolated distal dvt is therefore controversial and options include no treatment, follow-up scanning and treatment of only those patients with thrombus propagating to proximal veins, and full anticoagulation for periods ranging from 2 weeks to 3 months. there is good evidence that the 3-month thromboembolic risk in patients with a negative cus that is limited to the proximal veins is low, in the order of 1%. previous studies have demonstrated that patients treated with a short period of anticoagulation (4-6 weeks) have a low risk of developing recurrent dvt or pe. in addition, the specificity of cus for distal dvt is lower than that for proximal dvt, increasing the proportion of false positive findings, making it likely that a proportion of patients diagnosed with distal dvt are treated unnecessarily, with the attendant risks of major and fatal haemorrhage. the need for anticoagulation of patients with distal dvt to prevent recurrent dvt is therefore uncertain, however a survey of current practice suggested that most patients with this condition currently receive antithrombotic therapy. the impact of anticoagulation on initial patient symptoms, and the subsequent risk of the post-thrombotic syndrome are also unclear, and may be a possible alternative justification for antithrombotic therapy. in this proposed multicentre, prospective, cohort study, we plan to determine if a shorter duration of anticoagulation (minimum 2 weeks) is a safe and effective treatment for isolated distal vein thrombosis.

Eligibility criteria:
inclusion criteria: * patients aged 18 years or older with acute symptomatic provoked or unprovoked distal vein thrombosis (axial or muscular veins but not involving trifurcation or distal popliteal vein) * absence of symptomatic pulmonary embolism exclusion criteria: * dvt involving trifurcation or more proximal leg veins on imaging * prior dvt * active malignancy ie present at time of diagnosis, or on treatment, or treatment completed within 3 months * ongoing risk factors for propagation e.g. immobility (\>50% of day in bed or ≥72 hours), plaster cast or non-weight bearing * other indication for therapeutic anticoagulation (e.g. af) * active gastro-oesophageal ulceration or bleeding * other high risk for bleeding (e.g. recent neurosurgery, vascular retinopathy, coagulopathy) * platelet count \<80 x 109/l * renal impairment (crcl \<30ml/min) • pregnancy or lactation

Keywords: distal vein thrombosis proximal vein thrombosis pulmonary embolism post-thrombotic syndrome limited duration treatment
migraine in poland - a web-based cross-sectional survey

Conditions: Migraine

Summary: a survey of polish respondents will aim to define migraine characteristics in polish subjects. to achieve this, a structured questionnaire based mainly on american migraine prevalence and prevention study has been prepared to serve as a tool for data extraction. the obtained data should allow for defining disease parameters, burden and received treatments. additionally questions regarding patients rhinological symptoms and covid-19-related history were included.


Eligibility criteria:
inclusion criteria: * consent to participate in the study exclusion criteria: * responses missing in questionnaire

Keywords: migraine headache rhinosinusitis covid-19
validation of a molecular prognostic test for eye melanoma

Conditions: Uveal Neoplasms; Choroid Neoplasms; Iris Neoplasms

Summary: up to half of patients with ocular melanoma (also called iris, choroidal or uveal melanoma) develop metastasis. we have found that certain molecular features of the eye tumor can be detected by gene expression profiling and accurately predict which patients will develop metastasis. this molecular test could eventually allow high risk patients to receive preventative therapy to delay or prevent the development of metastasis. the goal of this study is to prospectively validate the predictive accuracy of the gene expression-based molecular test and compare it to monosomy 3, the most common but potentially less accurate molecular marker for metastasis in ocular melanoma.

we have discovered a gene expression profile derived from primary uveal melanomas that accurately predicts which patients will develop metastasis. tumors with a class 1 gene expression signature have a very low risk, and those with a class 2 signature have a high risk of metastasis. the molecular test was initially performed on tissue obtained from enucleated eyes using commercial microarray platforms. we are now able to perform the molecular test on fine needle biopsy specimens, and we have developed a customized test that has greater dynamic range and sensitivity than commercial microarray platforms. the goal of this study is to validate the prognostic accuracy of the customized platform by performing the molecular test on primary uveal melanomas obtained from enucleation, local tumor resection or fine needle biopsy. each sample will be diagnosed as either class 1, class 2 or indeterminate. outcomes will be collected and the ability of the molecular diagnosis to predict metastasis will be evaluated at regular intervals.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of melanoma of the iris, ciliary body and/or choroid * treatment to include enucleation, radiotherapy or local tumor resection exclusion criteria: * evidence of marked tumor necrosis

Keywords: eye uvea iris choroid ciliary body melanoma iris melanoma choroidal melanoma ciliary body melanoma uveal melanoma posterior uveal melanoma prognosis metastasis genetic testing molecular testing gene expression profiling
free fatty acids: threshold repeatability study

Conditions: Taste, Non-esterified Fatty Acids

Summary: this study seeks to determine if non-esterified fatty acid (nefa) taste detection thresholds change with repeated testing. threshold testing for nefa taste has been reported by a number of laboratories, including our own; however, these studies have reported data for only one testing occasion. the investigators seek to conduct repeated testing to measure the test-retest reliability of these methods. the investigators believe that with repeated exposure to nefa, a person's sensitivity increases. the investigators are also testing the efficiency of testing by two methods (forced-choice ascending trial versus staircase). additionally, the association between taste responses, diet and bmi will be explored.


Eligibility criteria:
inclusion criteria: * 18-55 years old * in good health * available for three months exclusion criteria:

Keywords: taste fat threshold sensitivity human
treadmill stress test with and without mask

Conditions: Healthy

Summary: the purpose of this study is to assess if wearing a surgical mask affects the results of a standard treadmill test.

the persons interested to participate will be informed of the implication and potential risks associated with the study. the participants that accept and meet the eligibility criteria will give written consent and be randomized into two groups. one group will first perform a treadmill test with a surgical mask and then repeat the test without a mask. the second group will do the first treadmill test without a mask and the second one with a surgical mask.

Eligibility criteria:
inclusion criteria: * adults (18-65 years old) * healthy * vaccinated against covid-19 exclusion criteria: * any cardiac or respiratory condition * walking difficulty * waiting for a stress test for a medical reason * abnormal resting ecg * inability to wear a mask * inability to understand or follow the instructions * medical contraindication to performing a treadmill stress test

Keywords: treadmill bruce covid-19 mask healthy adults mets metabolic equivalent borg exercise stress test
influence of a prematuration culture with a phosphodiesterase-3 inhibitor (pde3-i) on embryonic aneuploidy rate and developmental potential

Conditions: Infertility

Summary: a single centre randomised controlled trial investigating the influence of a novel prematuration system (pms) using a phosphodiesterase-3 inhibitor for in-vitro maturation of oocytes


Eligibility criteria:
inclusion criteria: * healthy volunteers, either with pcos/pcos-like ovaries, or with normal ovaries, who undergo oocyte donation for research * afc at least 10 * amh: \> 5 μg/l * female age \< 36 years exclusion criteria: * major uterine or ovarian abnormalities

Keywords: pcos and normal ovulatory patients aneuploidy in-vitro maturation of oocytes
evaluation of periodontal diseases and obesity in women

Conditions: Periodontal Diseases; Obesity

Summary: the aim of this study was to evaluate the effect of obesity and exercise on periodontal and biochemical parameters \[serum, saliva and gingival crevicular fluid (gcf) adipokines (interleukin-1β, tumor necrosis factor-α, leptin, resistin and adiponectin)\].

it is thought that adipokines may play a role on periodontal disease in obese subjects, periodontal disease may also aggravate the existing systemic disease by changing the inflammatory parameters in the body. the aim of this study was to evaluate the effect of obesity and exercise on periodontal and biochemical parameters \[serum, saliva and gingival crevicular fluid (gcf) adipokines (interleukin-1β, tumor necrosis factor-α, leptin, resistin and adiponectin)\].

Eligibility criteria:
inclusion criteria: * being women, * older than 18 yrs old, * not being pregnant, * not being disabled, * for study group; being obese, not for healthy group being systemically health and in normal weight * not treated periodontological in the last 6 months exclusion criteria: * younger than 18 yrs old, * smokers who smokes more than 10 cigarettes in a day, * uncontrolled systemic diseases, * having periodontal treatment * who needs antibiotic prophylaxis

Keywords: obesity periodontal diseases gingival crevicular fluid saliva serum
evaluation of the efficacy and neurological effects of dry needling in the treatment of myofascial pain syndrome

Conditions: Myofascial Pain Syndrome

Summary: aim of investigation: to evaluate in a prospective, randomized, sham-controlled study the pattern of analgesic efficacy of trigger point dry needling in myofascial pain syndrome (mps) patients.

this study will be performed in patients with shoulder pain due to excess of nociception associated with chronic myofascial pain syndrome in asymmetrical unilateral trapezius muscle trigger points. patients will be randomly assigned to two treatment arms: active (a) (n=20) and sham (s) (n=21). group a will receive actual treatment with trigger point dry needling. group s will receive a sham treatment, with the needle inserted superficially in the skin, without reaching the muscle underneath it. the duration and pain elicited during active and sham dry needling will be controlled for. patients will be evaluated one week before needling (d-7), on the day of dry needling (d0) and seven days after the procedure (d+7). patients will fill out the brazilian version of the douleur neuropathique 4, beck depression inventory, brief pain inventory (bpi), mcgill pain questionnaire-sf (sfmpq), hospital anxiety and depression scale and global impression of change, and also a 14-day carnet to more accurately evaluate their daily pain before and after the treatment. for the evaluation of neurologic changes, we will evaluate local hyperalgesia, tactile, mechanical, static and thermal sensitivity with thermal quantitative sensorial testing (tqs), and also mapping of the painful area, before and after treatment in both d0 and d+7.

Eligibility criteria:
inclusion criteria: * assymetric shoulder pain (vas on painful side : vas on non painful side \> 2:1) * pain due to unilateral myofascial pain syndrome of the trapezius muscle. * chronic pain, with duration of at least 3 months and vas \> 40/100 * patients with pain at least 4 days in a week * patients without neurological pain, as in dn4 score less than 4 * age over 18 years * patients with stable drug treatment over at least 15 days, without any acute pharmacological changes during the study * patients who read, understood and signed the free and clarified consent term exclusion criteria: * patients with major depression, according to dsm-iv criteria * history of bipolar mood disorder, panic syndrome or psychosis * intermittent pain history * refusal to sing the consent term * patients not able to attend all the follow-ups * patients with another pain syndrome in shoulders

Keywords: myofascial pain syndrome dry needling clinical trial
comparison of biphasic insulin aspart 70/30, 50/50, and 30/70 in subjects with type 2 diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2

Summary: this trial is conducted in europe. this trial aims for a comparison of the effect on glycemic control in subjects with type 2 diabetes of three different premixed insulin analogues given in combination with an oral anti-diabetic drug.


Eligibility criteria:
inclusion criteria: * type 2 diabetes * currently treated with insulin * currently treated with metformin * hba1c: 7.5-12.0% exclusion criteria: * body mass index (bmi) \ 40.0 kg/m2 * metformin contraindications according to local practice * tzds within 6 months prior to randomisation
implementing exercise into clinical practice in breast cancer care

Conditions: Breast Cancer

Summary: background: one in eight women will develop breast cancer in their lifetime. with improved screening and treatment techniques, more women are surviving breast cancer. however, women live with physical and emotional side effects secondary to treatment for years after cancer treatments have ended. exercise can help to manage these side effects, however, less than 30% of this population takes part in regular exercise. the objective of this trial is to determine the feasibility and effectiveness of a novel exercise and education program for women with breast cancer during chemotherapy. methods: participants in this study include women with a diagnosis of stage 1 - 3 breast cancer undergoing chemotherapy. women will be divided into three groups. the first group will include 8 sessions of exercise and self-management education during their chemotherapy treatment. the second group will receive self-management education only, and the third group will receive usual care. outcomes will be compared between groups at baseline, post-intervention, and at 6- and 12- month follow up. outcomes to be assessed include exercise level, functional mobility, muscle strength, quality of life, health status, and use of health care services. expected outcomes: women with breast cancer are among the least active segment of the canadian population. it is well known that inactivity can lead to physical and psychological side effects, cancer recurrence, and an increase in comorbid conditions. this proposed project addresses a long-standing need to help women with breast cancer become and stay more active by implementing a novel exercise and education program.


Eligibility criteria:
inclusion criteria: * community-dwelling * english-speaking women * over 18 years of age * currently undergoing adjuvant or neoadjuvant chemotherapy for stage 1-3 breast cancer * cleared by their oncologist to participate in moderate intensity aerobic exercise exclusion criteria: * self-report any chronic condition, cognitive impairment, or injury that would prevent them from participating independently in moderate intensity exercise

Keywords: exercise physical activity self-management
double kissing-crush vs controlled balloon-crush techniques for complex coronary bfurcation lesions

Conditions: Coronary Arterial Disease (CAD); Percutaneous Coronary Intervention (PCI); Bifurcation Coronary Disease

Summary: the crush technique for coronary bifurcation lesions has evolved significantly since its introduction to the literature by colombo et al. in 2003, with several iterations, including double kissing balloon inflation. the main disadvantage of the historical crush technique is the low success rate of the final kissing balloon inflation. an improvement came with the introduction of double kissing crush stenting aiming for the shorter protrusion and kissing balloon dilation performed before and after main branch stent implantation. the double kissing crush provides a significant reduction in major adverse cardiovascular events compared to provisional stenting, crush, and culotte techniques. recently, a novel modified mini-crush technique (controlled balloon-crush) has been introduced to the literature and is one of the most up-to-date crush techniques. the main advantage of this technique over the contemporary mini-crush technique is that the side branch can be easily rewired, and the 1:1 size non-compliant balloon can easily pass through the crushed stent structure in the ostial part of the side branch. the basic rationale of this is that the crushing of the side branch stent is done in a more controlled manner (by slowly deflation of the side branch stent balloon), and this causes less disruption of the stent cells. to date, no data compares the mid-term outcomes of double kissing crush and controlled balloon-crush stenting techniques in patients with complex coronary bifurcation lesions. hence, this study aimed to determine the clinical results of double kissing crush and controlled balloon-crush techniques under mid-term follow-up.


Eligibility criteria:
inclusion criteria: * aged \>18 * pci with either dk-crush or controlled balloon-crush * complex coronary bifurcation lesion (medina 0.1.1, medina 1.1.1) exclusion criteria: * non-complex bifurcation anatomy * bail-out 2-stent (reverse modified mini-crush) * st-elevation myocardial infarction * cardiogenic shock status * in-stent restenosis * a previous of coronary artery bypass grafting * implantation of bare-metal stent * end-stage hepatic or renal disease * \<1-year life expectancy
a computer-based ed intervention to improve pediatric asthma medicine adherence

Conditions: Asthma

Summary: asthma is common in children and impacts their health. there are effective medications for improving asthma, but some families have difficulty using medicines on a regular basis. this study in the emergency department will improve medicine use for children 2-12 years-old with asthma by developing content for a customized, tablet-based electronic intervention. a clinical trial will then be used to compare asthma outcomes for this intervention with routine asthma care.

the investigators have used focus groups to get ideas from parents of children with asthma to best design the intervention. this has helped us create the questions that are being used in the intervention, and make the computer program appealing and acceptable to parents of children with asthma. the investigators will study the success of the intervention for children who receive it compared to children who obtain routine emergency department care. participants who receive the intervention will complete a series of questions on a tablet computer. questions will guide creation of individualized education and advice to improve medication use for each participant. the intervention will also allow for customized communication with each child's primary care provider. the investigators will include educational boosters at 2 and 4 weeks after the intervention delivered as chosen by the participant (email / text / rss / mail). children in the routine asthma care arm will not receive the intervention, and instead will receive routine discharge instructions by the emergency room doctors. the investigators will compare the success of the intervention group to routine emergency department care by using a device (doser ct) that measures daily administered doses of medicine. data from the doser ct will be collected monthly at home visits for three months. the investigators will also measure health care use and quality-of-life for each child using a survey at these home visits. the investigators believe that the intervention will improve doses of medicine given, reduce unnecessary health care use, and improve children's quality of life.

Eligibility criteria:
inclusion criteria: * asthma diagnosis by physician or parent report * ages 2-12 * prescribed an inhaled corticosteroid asthma controller medicine exclusion criteria: * parent does not speak english * child is prescribed inhaled corticosteroid seasonally * patient is on a combination inhaled corticosteroid controller asthma med

Keywords: asthma medication adherence intervention study
carbon monoxide headache triggering properties as well as effects on the brain's vessels and blood flow

Conditions: Headache Disorders

Summary: studying carbon monoxide effects on brain vessels in healthy volunteers with magnetic resonance imaging.

in this study we will systematically investigate the headache-releasing properties of carbon monoxide as well as measure the effect of carbon monoxide on mean blood flow rate in the brain's large vessel with magnetic resonance imaging. these studies are important for understanding and further investigating the carbon monoxide's headache-releasing effect in healthy subjects.

Eligibility criteria:
inclusion criteria: * healthy volunteers * aged 18-50 * 50-100 kg exclusion criteria: * tension type headache more than 5 dage /month * other primary headaches * daily medication except contraceptives * drug taken within 4 times the halflife for the specific drug except contraceptives * pregnant or lactating women * exposure to radiation within the last year * headache within the last 24 hours before start of trial * hypertension * hypotension * respiratory or cardiac disease * smoking * primary relatives with current or previous migraine