Kornimate/medical-research-clean huggingface dataset:
third-generation egfr-tki plus anlotinib as maintenance for nsclc with small cell transformation after egfr-tki resistance

Conditions: Non-small Cell Lung Cancer

Summary: this study aimed to evaluate the efficacy and safety of third-generation egfr-tki plus anlotinib as maintenance after chemotherapy plus immunotherapy in advanced nsclc with small cell transformation after egfr-tki resistance.

this prospective interventional clinical study aims to evaluate the efficacy and safety of third-generation egfr-tki combined with anlotinib as maintenance therapy following 4-6 cycles of chemotherapy and immunotherapy in patients with advanced nsclc who developed small cell transformation after egfr-tki resistance.approximately 30 non-small cell lung cancer patients who developed small cell transformation after egfr-tki resistance were enrolled and treated with 4-6 cycles of chemotherapy plus immunotherapy followed by maintenance therapy with third-generation egfr-tki combined with anlotinib.the study is expected to commence recruitment in mainland china in about november 2024. it is expected that the trial will end in december 2026.

Eligibility criteria:
inclusion criteria: * 1. understand the requirements and contents of the clinical trial, and provide a signed and dated informed consent form. * 2. age ≥ 18 years. * 3. histopathology is confirmed non-small cell lung cancer . * 4.patients with advanced non-small cell lung cancer (nsclc) who experienced small cell transformation after egfr-tki resistance. * 5. predicted survival ≥ 12 weeks. . * 6. ecog 0-2. * 7. adequate bone marrow hematopoiesis and organ function. exclusion criteria: * 1. history of other malignant tumors within 2 years. * 2. adverse events (except alopecia of any degree) of ctcae \> grade 1 due to prior treatment (e.g., adjuvant chemotherapy, radiotherapy, etc.) prior to the first dose. * 3. history of stroke or intracranial hemorrhage within 6 months prior to the first dose. * 4. the presence of any severe or poorly controlled systemic disease, including poorly controlled hypertension and active bleeding in the judgment of the investigator. * 5. subjects with persistent or active infection, including but not limited to hepatitis b (hbv), hepatitis c (hcv), human immunodeficiency virus (hiv) and covid-19 infection. * 6. heart-related diseases or abnormalities * 7. past history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis requiring steroid therapy or interstitial lung disease with active clinical symptoms, immune pneumonia caused by immunotherapy. * 8. refractory nausea and vomiting, chronic gastrointestinal disease, difficulty swallowing drugs, or inability to adequately absorb sunvozertinib or anlotinib due to previous bowel resection. * 9. live vaccine was given 2 weeks before the first medication. * 10. women who are breastfeeding or pregnant. * 11. hypersensitivity to the test drug and the ingredients. * 12. other conditions assessed by the investigator to be unsuitable for participation in the study.
the causal relation of nasal nitric oxide levels to the severity of chronic rhinosinusitis and its inflammatory phenotype

Conditions: Chronic Rhinosinusitis (Diagnosis)

Summary: nitric oxide (no) reflects changes in inflammatory state of the airways. in pulmonology fractional exhaled nitric oxide concentration (feno) has been linked to eosinophilic asthma and is used to guide overall disease control. the measurement of nasal nitric oxide (nno) may reflect the disease burden and inflammatory phenotype of the paranasal sinuses. the aim of our study is to evaluate the relation of chronic rhino sinusitis (crs) severity and inflammatory status to nno, maxillary sinus no, nitrite, nitrate and cone beam computed tomography (cbct). three groups (22 patients in each) of referred patients and and 22 healthy volunteers are recruited. patients are grouped according to the cbct score and viewed three times in 4-6 weeks intervals.


Eligibility criteria:
inclusion criteria: * patients willing to participate in the study * patients who are referred to ent clinic due to chronic rhinosinusitis (epos criteria) or repeatedly diagnosed and treated acute rhinosinusitis exclusion criteria: * endoscopic sinus surgery operation previously * septal deviation that would need an operation to correct the air flow * other severe disease that could pose a risk for the patient during the measurements based on the judgement of the treating physician * pregnancy or breastfeeding * allergy to used medications * inability to co-operate or to tolerate manipulation of the nose

Keywords: nasal nitric oxide nitric oxide metabolites
evaluating the efficacy of a brief online intervention among current heavy drinkers

Conditions: Alcohol Consumption

Summary: unhealthy alcohol consumption is common in the uk and causes tremendous harm to the individual, as well as harm to others. a significant gap in providing alcohol support is that most people with unhealthy alcohol consumption will never receive advice to cut down on their drinking. however, many are interested in self-directed interventions to help them evaluate their drinking and to motivate reductions in alcohol use. one such promising intervention uses online personalised normative feedback (pnf) which compares a person's drinking with others in the general population of the same age and sex. pnf interventions are thought to work because many people with unhealthy alcohol consumption overestimate how much others drink. multiple trials have demonstrated that providing pnf to people with unhealthy consumption reduces their alcohol use . while several uk websites do provide feedback on assessment of risk (e.g., down your drink introductory section, alcohol change uk), there appears to be no online intervention that provides pnf for unhealthy alcohol consumption. the major objective of this pilot project is to conduct a two-arm, parallel group randomised controlled trial (rct) in which 1,318 participants recruited from the prolific website who have identified themselves as drinking 14 or more units per week are randomly assigned to one of two groups - a) those who are offered a pnf report, and b) those in a no intervention comparator group. participants in the comparator group will not be provided any intervention materials but will instead be given a list of the different components of the pnf feedback and will be asked to think about how useful they would find each of them. follow-up assessment will occur at 1 and 6 months post-randomisation. the project is described as a pilot because it is a preliminary evaluation of the pnf intervention in a uk context.


Eligibility criteria:
inclusion criteria: 1) score 8 or more on the audit (indicating current unhealthy alcohol use); and 2) endorsed the attention check questions correctly. exclusion criteria: not meeting these inclusion criteria forms the exclusion criteria
early rheumatoid arthritis lung disease study

Conditions: Rheumatoid Arthritis

Summary: extra-articular (outside of joints) disease occurs in approximately 50% of rheumatoid arthritis (ra) patients, with the lung being a common site of involvement. the goals of this study are to investigate and characterize lung disease and its prevalence in early ra participants. this will be done through pulmonary function and high resolution chest computed tomography (ct), questionnaires, and serum studies. another goal is to find novel biomarkers, such anti-malondialdehyde-acetaldehyde (maa) antibodies, as predictors of lung disease in ra participants.

extra-articular (outside of joints) disease occurs in approximately 50% of rheumatoid arthritis (ra) patients, with the lung being a common site of involvement. the purpose of this study is to characterize the prevalence and classification of lung disease in participants with newly diagnosed rheumatoid arthritis by prospectively gathering information on lung imaging and function, comorbidities and novel biomarkers, such as anti-malondialdehyde-acetaldehyde (maa). specifically, the study would determine whether (maa) adduct antibody concentrations predict computed tomography (ct) changes consistent with ra-lung involvement and determine whether anti-maa antibody concentrations predict pulmonary function abnormalities in forced vital capacity (fvc), forced expiratory volume in 1 second (fev1), and diffusion lung capacity of carbon monoxide (dlco). an additional goal is to develop a cohort of newly diagnosed ra patients who can be followed long-term through electronic medical record (emr) surveys, and biobank samples.

Eligibility criteria:
inclusion criteria: * 19-90 years of age * able to give informed consent * diagnosis of ra by a rheumatologist using 2010 american college of rheumatology (acr) criteria within the past 2 years exclusion criteria: * inflammatory arthritis that does not meet 2010 american college of rheumatology (acr) criteria for rheumatoid arthritis (ra) * pregnant

Keywords: newly diagnosed rheumatoid arthritis lung disease
glild diagnosed in children and young adults with common variable immunodeficiency

Conditions: GLILD in a Population of Children and Young Adults

Summary: 8 to 22% of patients with common variable immunodeficiency (cvid) will develop granulomatous lymphocytic interstitial lung disease (glild), which has emerged as a major cause of mortality. little is known about glild in children and young adults. the aim of this study was to describe the clinical, functional, radiological and pathological features of children and young adults diagnosed with glild.

variable common immunodeficiency (vcid) encompasses a heterogeneous group of primitive immunodeficiencies, with variable clinical and immunological settings, but globally characterized by hypogammaglobulinemia with significant reduction of immunoglobulin g levels, often associated with a decrease in immunoglobulin a and/or immunoglobulin m levels, coupled with inability to produce antibodies in response to infection and/or immunization. vcid is the most common primary immunodeficiency, with an estimated prevalence between 1/10,000 and 1/50,000. with the introduction of high-dose, intravenous or subcutaneous immunoglobulins, number of infections, along with morbidity and induced mortality, has declined sharply in recent years. conversely, non-infectious complications, such as autoimmune manifestations, inflammatory bowel diseases, enteropathies, hepatitis, lung disease and lymphoproliferation (up to lymphoma), increased considerably, reaching 70% of patients. granulomatous lymphocytic interstitial lung disease is a non-infectious complication that can occur during the evolution of vcid and which is usually the pulmonary manifestation of a systemic polyclonal lymphoproliferative disease. glild contained both granulomatous and lymphoproliferative histopathologic patterns such as lymphocytic interstitial pneumonia , follicular bronchiolitis, and lymphoid hyperplasia. in recent series, approximately 8 to 22% of patients develop glild in vcid, and this complication is associated with increased mortality. although there are now more studies conducted in the adult population, those in the pediatric population are only currently case report. to the best of our knowledge, very little data is available on this specific lung disease in the pediatric and young adults population.

Eligibility criteria:
inclusion criteria: * patient aged to 0 to 25 years old (at the diagnosis of glild) * diagnosed with a primary immunodeficiency syndrome "common variable immunodeficiency" like, according to the 1999 american and european societies for immunodeficiency criteria * suspected with glild (granulomatous lymphocytic interstitial lung disease exclusion criteria: * pulmonary diseases caused by other causes such as infectious or hypersensitivity pneumonitis

Keywords: glild common variable immunodeficiency children
effect of biomechanical stimulation on skeletal health in adolescent and young women with anorexia nervosa

Conditions: Anorexia Nervosa

Summary: this study will evaluate the effects of a novel, non-pharmacologic intervention for the prevention of deleterious changes in bone density and strength in adolescents with anorexia nervosa (an), a disease commonly treated with extended periods of bed rest and immobilization. the primary focus of the trial is to conduct a prospective short-term intervention to prevent an uncoupling of bone turnover in inpatients hospitalized for an, and to determine the long-term effects of a biomechanical intervention on skeletal health in ambulatory adolescents with an.


Eligibility criteria:
inclusion criteria: * age 11-25 years * diagnosis of anorexia nervosa based on dsm-iv criteria * female gender * english-speaking exclusion criteria: * • concomitant chronic diseases which affect bone health, such as cystic fibrosis, inflammatory bowel disease, celiac disease, renal disease, or diabetes mellitus * use of medications known to affect bone metabolism in the last 3 months, such as: * glucocorticoid therapy (including inhaled steroids) * anticonvulsants * combined estrogen/progestin contraceptive agents (oral contraceptive pills) * depot medroxyprogesterone (depo-provera) use in the last 12 months * current pregnancy

Keywords: skeletal health bone turnover bone geometry malnutrition
german off pump coronary artery bypass in elderly study

Conditions: Heart Disease

Summary: comparison of two operative techniques (on-pump vs off-pump)of coronary revascularisation of the best treatment concept for patients older or 75 years old. hypothesis: the coronary bypass operation without use of the heart-lung machine (off-pump=opcab) reduces the combined endpoint in comparison with the conventional coronary bypass operation (on-pump).


Eligibility criteria:
inclusion criteria: * older or 75 years * indication for elective bypass operation * patient has signed written consent before randomization exclusion criteria: * previous heart surgery * patient unable to give informed consent

Keywords: opcab coronary bypass grafting off pump
c-smart: cognitive strategies, mindfulness, and rehabilitation therapy for patients with primary brain tumors

Conditions: Glioma, Mixed; Mild Neurocognitive Disorder; Brain Tumor

Summary: the goal of phase iia trial is to determine the feasibility and acceptability of telehealth c-smart for patients with primary brain tumor and mild neurocognitive deficits (n=36) and their caregivers (n=36) a subset (n=10) of participants will undergo rs-fmri both pre- and post-c-smart to test feasibility of advanced functional imaging in this population.


Eligibility criteria:
inclusion criteria: 1. confirmed primary brain tumor diagnosis by histology or neuro-oncologist review of imaging 2. at least one domain of neurocognitive function \>1.5 sd below the average or the individual's estimated premorbid functioning, using the expanded icctf clinical trials battery and test of premorbid functioning for comparison 3. \>1 month post brain surgery and/or radiation therapy, if applicable 4. estimated premorbid intelligence \>75. 5. patients must be age 18+ and primarily english speaking exclusion criteria: 1. presence of major neurocognitive impairment that would prevent participation in the intervention, and/or severe aphasia, and/or inability to understand and provide informed consent 2. inability to attend weekly telehealth appointments; based on eab results 3. clinically significant insomnia symptoms 4. \< 1 month post brain surgery and/or radiation therapy 5. unstable internet connection or an inability to work teleconferencing software. participants will be supplied an ipad if they do not have an adequate device. 6. to participate in the fmri portion of this study participants cannot have any metal in their bodies. for the fmri subset, participants cannot have metal in their body as the mri scan could cause them harm and if female of childbearing years, they cannot be pregnant as the mri scan may pose risk to the unborn fetus.

Keywords: mindfulness cognitive rehabilitation rs-fmri
comparative study between oxytocin versus tranexamic acid and ethamsylate

Conditions: Blood Loss, Surgical; Blood Loss, Postoperative

Summary: comparative study between oxytocin versus tranexamic acid and ethamsylate, pre-operative administration.

caesarean delivery commonly referred to as caesarean section and occasionally caesarean birth is defined as the delivery of a foetus(es) through surgical incisions made through the anterior abdominal wall (technically referred to as laparotomy) and the anterior uterine wall (technically denoted to as hysterotomy). obstetric hemorrhage (intra operative or post operative bleeding)is still the major cause of maternal morbidity and mortality worldwide contributing to nearly 25% of direct maternal deaths. and accounts for 50% of maternal mortality in low-income countries. so many strategies reducing the intraoperative blood loss or post operative blood loss could be helpful in decreasing the risks of blood transfusion and the postoperative maternal morbidity. so these medications are such as oxytocin, carbetocin, misoprostol, prostaglandin f2 alpha, methylergonovine, tranexamic acid and etamsylate . have been tried before to control bleeding during and after cesarean section.

Eligibility criteria:
inclusion criteria: 1. pregnant females admitted for elective cesarean section. 2. gestational age (38 to 41 weeks). 3. age of the participants: 20 to 40 years. 4. body mass index (18.5 - 29.9). 5. singleton living fetus. 6. no medical disorders. 7. informed written consent from the candidates. exclusion criteria: 1. - medical and surgical disorders as thyroid dysfunction, which was excluded by routine thyroid function test (free t3, free t4, and thyroid-stimulating hormone(tsh), all of them should be within normal limits). 2. -bleeding tendency, was excluded by platelet count, coagulation time, bleeding time, prothrombin time, partial thromboplastin time, and thrombin time (all should be within normal). 3. -acute and chronic liver or kidney diseases; blood disorders, such as anemia. 4. -allergy to tranexamic acid or any drug used. 5. -risk factors for pph, such as polyhydramnios, fetal macrosomia, antepartum hemorrhage. 6. - abnormal placentae such as placenta previa and placental abruption. 7. -pregnancy complications such as severe pre-eclampsia, gestational htn, gestational dm, and multi fetal pregnancies, those requiring blood transfusion. 8. - patients who refused spinal anesthesia.

Keywords: blood loss cesarean section oxytocin tranexamic acid(kapron) etamsylate(dicynon).
evaluation of the effect of nirsevimab on hospitalizations due to rsv infection in infants under one year of age.

Conditions: Respiratory Synctial Virus Infections

Summary: this study aims to evaluate the impact of nirsevimab, a monoclonal antibody used for rsv prophylaxis, on reducing rsv- related hospitalizations. it will be conducted at 8 pediatric departments in tuscany, italy. first, a matched case-control study investigates the real-world effectiveness of nirsevimab in preventing rsv-related lower respiratory tract infection (lrti) hospitalizations during the rsv epidemic season 2024-2025. second, a descriptive study examines how the nirsevimab immunization campaign affects rsv epidemiology, focusing on patients' age, comorbidities, infection severity, and clinical outcomes. the findings aim to optimize rsv prevention strategies and inform public health policies.


Eligibility criteria:
inclusion criteria: case patients * age \<12 months * diagnosis of lrti (i.e., bronchiolitis and/or pneumonia) at admission * positive rsv pcr on nasopharyngeal swab control patients * age \<12 months * diagnosis of lrti (i.e., bronchiolitis and/or pneumonia) at admission * hospitalized for conditions other than respiratory infections exclusion criteria: * parental refusal * previous immunization with palivizumab * previous maternal rsv vaccine immunization during pregnancy
effect of back massage on ınfertılıty stress, sexual satısfactıon and marrıage harmony ın ınfertılıty couples

Conditions: Sexual Activity; Infertility; Stress

Summary: this study aimed to investigate the effect of back massage on infertility stress, sexual satisfaction and marital harmony in infertile couples. it aims to answer the question "does back massage increase sexual satisfaction and marital harmony in infertile couples?" they will apply infertile chirt back massage and then answer survey questions about sexual satisfaction and marital harmony.

infertility is defined as the inability to become pregnant despite regular, unprotected sexual intercourse for 12 months. infertility can cause decreased sexual satisfaction, deterioration of marital harmony and separation in couples. massage with contact and touch can increase harmony between couples, reduce stress and contribute to increased sexual satisfaction. this study aimed to investigate the effect of back massage on infertility stress, sexual satisfaction and marital harmony in infertile couples. the couples included in the study were divided into two groups: study and control groups. all patients completed the demographic information scale, the compi coping strategy scales, golombok rust sexual satisfaction scale and marital adjustment scale. back massage was taught to the couples in the study group and the spouses were allowed to perform back massage during the infertility treatment. no intervention was applied in the control group. a month later, the compi coping strategy scales, golombok rust sexual satisfaction scale and marital adjustment scale were repeated on the fences. mann whitney u test, ki kare test and wilxon test used to analyze data. marital harmony and sexual satisfaction were found to be higher and stress levels were lower in couples who received back massage. as a result, it has been shown that back massage has positive effects on infertility stress, sexual satisfaction and marital harmony in infertile couples.

Eligibility criteria:
inclusion criteria: being 18 years or older, being diagnosed with infertility, being married and spouses living together, being literate, there is no mental or psychological disorder/disability that would affect understanding and perception, not having a problem that prevents massage (must not be an extremity amputee, should not have a fracture or dislocation, should not have an open wound) exclusion criteria: * unable to communicate, * couples who do not want to participate in the research will not be included in the research. * those who have conditions that prevent massage (those with fever, wounds on their backs, individuals with tumors, the presence of an incomprehensible mass, those with orthopedic disorders, etc.) exclusion criteria for the control group * individuals who cannot be contacted and do not want to participate in the research will not be included in the research.

Keywords: infertility back massage sexual satisfaction