Kornimate/medical-research-clean huggingface dataset:
a single, ascending dose evaluation of the safety, pharmacokinetics of methylone in healthy subjects

Conditions: Post Traumatic Stress Disorder

Summary: this is an open-label, single, ascending dose study evaluating the pk and safety of methylone in healthy subjects.


Eligibility criteria:
key inclusion criteria: * healthy adult male or female aged 25 to 55 inclusive * normal resting ecg * normal hematologic and hepatic function * normal renal function key exclusion criteria: * vital sign abnormalities * positive urine drug screen at screening and / or day -1 * current mental illness such as depression, anxiety disorder, schizophrenia or other psychotic disorders
metvix daylight pdt in actinic keratosis

Conditions: Actinic Keratosis

Summary: prospective non-interventional study conducted in australia, brazil, mexico and europe to evaluate clinical practice with metvix daylight pdt in the treatment of mild to moderate actinic keratosis of the face/scalp and to assess physician and patient satisfaction.


Eligibility criteria:
inclusion criteria: * patients to whom metvix® daylight-pdt has already been prescribed by their physician, according to the local label;
ketamine and postoperative depressive symptom-passion

Conditions: Ketamine; Depressive Symptom; Neurosurgery; Perioperative Period

Summary: perioperative depression symptom (pds) is one of the common mental comorbidity, and influences the clinical outcomes and prognosis. however, there is no rapid acting treatment to deal with it during the limited hospital stay. this study aims to determine whether ketamine could improve the depressive symptom of peirioperative patients. it will also examine the safety for administrating ketamine as an antidepressant intraoperatively. meanwhile, it will show if ketamine could improve anxiety, postoperative pain or delirium. this trial also will bring great concerns on patients with perioperative mental health and explore the measures to improve their psycho-related prognosis.


Eligibility criteria:
inclusion criteria: 1. brain tumor located supratentorial area and need to receive elective craniotomy; 2. moderate to severe depressive symptom measured by the qualified psychiatric doctors. 3. ages between 18 and 65 years old. 4. american society of anesthesiologists physical status i-iii exclusion criteria: 1. history of epilepsy; 2. major depression disorder patients undergoing antidepressive therapy within 2 weeks; 3 psychiatric illness; 4 drug abuse; 5 history of allergy to the research drug; 6 tumor located in the wernick area, broca area or the frontal pole; 7 hyperthyroidism; 8 patients can not cooperate with investigators on psychiatric assessments; 9 pregnant or breast-feeding woman; 10 refuse to sign inform consent.
deep rtms in parkinson disease pain syndromes

Conditions: Pain; Parkinson Disease

Summary: pain is the most prevalent non-motor symptom in parkinson disease, and the motor improvement not always is related to the pain improvement with the medication treatment. by this, we are testing a non-invasive method called transcranial magnetic stimulation as an alternative to treat pain related to parkinson disease. this technique can lead to either inhibitory or excitatory effects in brain circuits depending on stimulation parameters, and is known to provide analgesic effects.


Eligibility criteria:
inclusion criteria: * parkinson disease * signed term of informed consent * parkinsson disease related pain exclusion criteria: * trauma of skull, epilepsy don't treated * use of medications decrease the seizure threshold * patients in use of drugs, how cocaine and alcohol * neurosurgical clips, pacemakers, increased intracranial pressure (risk of sequelae after seizure) * pregnant or lacting women * moderate or severe cognitive impairment

Keywords: deep repetitive transcranial magnetic stimulation chronic pain parkinson treatment non-motor symptom
augmenting reactive stepping with fes after sci

Conditions: Spinal Cord Injuries

Summary: up to 25 individuals living with chronic incomplete spinal cord injury (isci) who can stand but have limited ability to elicit a step without physical assistance or upper limb (u/l) support will be recruited for this study. the first objective of the study will aim to investigate the orthotic effect (i.e., immediate effect) of fes on the reactive stepping response. the second objective is to investigate the therapeutic effect of a novel balance intervention, perturbation-based balance training (pbt) combined with fes (i.e., pbt+fes) on reactive stepping ability, measures of postural sway during quiet standing (i.e., biomechanical measures), and scores on clinical measures of balance and walking.


Eligibility criteria:
inclusion criteria: 1. have a motor incomplete sci (i.e., ais grade c or d) that is non-progressive; 2. be at least one year post-injury (i.e., chronic injury); 3. ≥ 18 years old; 4. be able to stand independently for 60 sec; 5. unable to take a step bilaterally without physical assistance or upper extremity support; 6. able to understand spoken english; 7. free of any other condition besides sci that significantly affects walking or balance (e.g., no vestibular disorder, significant vision loss, stroke); 8. be able to provide informed, written consent. exclusion criteria: 1. contraindications for ems. electrical stimulation will not be used if: * it will be applied to areas where it could cause malfunction of electronic devices, including cardiac pacemakers; * a woman is pregnant; * the applied region has known or suspected malignancy; * the person has active deep vein thrombosis or thrombophlebitis; * there are active bleeding tissues, or the person has untreated hemorrhagic disorders; * there are infected tissues, tuberculosis, or wounds with underlying osteomyelitis; * tissues have been radiated in the past six months; * there are damaged skin areas or at-risk skin areas that would result in uneven conduction of current; 2. severe spasticity is present in the legs; 3. the person has contractures in the lower limbs that prevent achieving a neutral hip and ankle position, or extended knee; 4. there is a history of prior lower limbs fragility fracture; 5. the leg muscles are unresponsive to electrical stimulation (i.e., peripheral nerve damage in the legs). 6. pressure sores on pelvis or trunk, where safety harness will be donned.
clinical study of glycosylated extracellular vesicles for early diagnosis of breast cancer

Conditions: Breast Cancer

Summary: this is a prospective, single-center, non-randomized, cohort study designed to evaluate the clinical diagnostic performance of glycosylated extracellular vesicles and their contents for early detection of breast cancer.

early screening technology can improve the survival rate of breast cancer patients. traditional mammography and ultrasonography have limitations on performance in clinical practice. extracellular vesicles, one of the three major resources of liquid biopsy, contain multi-omics information that can be used to discover effective biomarkers for early diagnosis and screening of cancers. in this study, we are going to isolate glycosylated extracellular vesicles from serum of cancer patients and non-cancer people with the novel glyexo-capture technology, and perform mirna sequencing to selected out breast cancer-related markers. then an early diagnosis model of breast cancer based on the glyexo-capture platform is able to be established using machine learning techniques and validated by qpcr experiments.

Eligibility criteria:
inclusion criteria: 1. patients≥18 years old； 2. histologically confirmed breast cancer patients，benign breast disease （ig. breast fibroma, intraductal papilloma,mammary hyperplasia, breast cyst）or no breast lesions detected by clinical examination/mammography/ultrasound/breast magnetic resonance imaging (mri) 3. previous not received preoperative radiotherapy, chemotherapy, endocrine therapy, immunotherapy, or other anticancer treatments. 4. subjects signed informed consent； exclusion criteria: 1. a history of prior or concomitant malignancies; 2. advanced stage breast cancer (stage iv)； 3. patients were accompanied by severe organic diseases such as heart and cerebral disease, and liver and kidney disease.； 4. pregnant or lactating women ； 5. suspected or confirmed lesion was surgically removed； 6. patients with incomplete clinical data； 7. patients with poor compliance； 8. patients with severe mental illness； 9. patients had received blood transfusions during one month一；
mammogram mail- and phone-based interventions

Conditions: Breast Cancer

Summary: the project aims to evaluate four different versions and modalities of interventions encouraging mammogram screening among all eligible women due or overdue for screening. the evaluation will compare among the following forms of outreach to help determine whether (a) live calls are more effective at increasing mammogram screening than other forms of outreach and (b) each form of outreach is more effective than no outreach: (1) a postcard, (2) a letter, (3) an auto-dialer phone message, and (4) a live call from a care gaps team. the interventions will be rolled out over many months, allowing for comparisons of effectiveness against those who have not yet been contacted.


Eligibility criteria:
inclusion criteria: * female geisinger health plan members between ages 52 and 74 as of december 31, 2023 * overdue for annual mammogram * continuously enrolled with the geisinger health plan as of october 1, 2021 * can be contacted via both phone and mail exclusion criteria: * geisinger health plan members on a do-not-contact list * had a mammogram as of october 1, 2021 * in hospice, using hospice services, or receiving palliative care as of january 1, 2023 * medicare members 66 years of age or above at time of outreach, who are institutionalized or have both frailty and advanced illness * had a bilateral mastectomy at any time

Keywords: economics, behavioral mammography risk reduction behavior communication
potential risk for bacterial contamination in ventilator systems

Conditions: Contaminated Medical or Biological Substances; Environmental-Pollution-Related Condition

Summary: background: few studies have investigated the difference of bacterial contamination between conventional reused ventilator systems and disposable closed ventilator-suction systems. the aim of this study was to investigate the bacterial contamination rates of the reused and disposable ventilation systems, and the association between system disconnection and bacterial contamination of ventilator systems. methods: the enrolled patients used a conventional reused ventilator system and a disposable closed ventilator-suction system, respectively, for a week; specimens were then collected from the ventilators' internal system to evaluate human and environmental bacterial contamination. the sputum specimens from patients were also analyzed in this study. results: the detection rate of bacteria in the conventional reused ventilator system was substantially higher than that in the disposable system. the inspiratory and expiratory limbs of disposable closed ventilator-suction system had higher bacterial concentrations than the conventional reused ventilator system. the bacterial concentration in the heated humidifier (hh) of the reused system was significantly higher than that in the disposable system. positive associations existed among the bacterial concentrations at different locations in the reused and disposable ventilator systems, respectively. the predominant bacteria identified in the reused and disposable ventilator systems included acinetobacter spp., bacillus cereus, elizabethkingia spp., pseudomonas spp., and stenotrophomonas (xan) maltophilia. conclusion: both the reused and disposable ventilation systems had high bacterial contamination rates after one week of use. disconnection of the ventilator systems should be avoided during system operation for decreasing the risks of environmental pollution and human exposure, especially for the disposable system.

the intubated and mechanically ventilated patients were enrolled from the intensive care unit of chang gung memorial hospital, taiwan. the experimental study group was assigned to a disposable ventilator system combined with an auto-filled heated humidifier (hh), a closed suction catheter, and a closed aerosol therapy procedure with a valved t-adaptor. according to clinical commonly used system, the control study group was assigned to use with conventional reused ventilator system, combined with a manually filled hh, an open suction catheter, and a conventional aerosol therapy procedure. every patient was use above both ventilator systems.

Eligibility criteria:
inclusion criteria: * the mechanically ventilated patients in the icu exclusion criteria: * the sputum culture results of the patients indicated the presence of drug-resistant bacteria, influenza virus, and early extubation.

Keywords: nosocomial infection ventilator system closed suction system open suction system bacterial contamination
does it make sense to give postoperative antibiotics to patients with an uncomplicated acute cholecystitis

Conditions: Uncomplicated Acute Cholecystitis

Summary: each patient is preoperatively treated once profylactic with intraveneous antibiotics. postoperatively, one group will be treated with intraveneous antibiotics during 5 days. the other group will receive no antibiotics.


Eligibility criteria:
inclusion criteria: * uncomplicated acute cholecystitis \< 5 days(confirmed by echography and blood sample) * \> 18 years old exclusion criteria: -
safety and efficacy study of 10xb-101 in adults with bilateral flank adiposity

Conditions: Subcutaneous Fat Disorder

Summary: the goal of this clinical trial is to test the safety and effectiveness of an injection study drug in decreasing bilateral flank adiposity. the main question it aims to answer is: •how safe and effective is the injection study drug in removing bilateral flank adiposity compared to a placebo? participants will be: * be given injections every month for 5 months over the right and left flanks. * be asked to be seen in the clinic for 13 visits and 3 phone call visits during a duration of 1 year.

fifteen subjects with bilateral flank adiposity will be enrolled across 1-3 sites in the usa.

Eligibility criteria:
inclusion criteria: * subject is a male or non-pregnant female 18 to 55 years old. * subject has provided written informed consent. * subject has qualifying fat evaluation and skin laxity scores on each right and left flanks. * subject has had a stable body weight for the past 6 months prior to starting study. * subject is willing to undergo test article injections as directed, comply with study instructions, and commit to all follow-up visits for the duration of the study. exclusion criteria: * subject is pregnant, lactating, or is planning to become pregnant during the study. * subject has loose skin in the right and left flank areas, unrepaired abdominal injury or defect, scars, tattoos, or other features that may interfere with evaluation of localized fat, in the opinion of the investigator. * subject has any medical condition or taking medications that affects clotting and/or platelet function * subject has a history of allergy or sensitivity to polidocanol or any of the other ingredients in the test articles.

Keywords: right and left flank fat
strategy to adapt botulinum toxin doses in dystonia

Conditions: Dystonia

Summary: the study is designed to observ and collect the doses of botulinum toxin injected in dystonia in different centres to compare the initial dose and the dose recommended. we we ll study the increase of the dose injected over the time, the side effects... the hypothesis is that we inject smaller doses than we could regarding the recommandations


Eligibility criteria:
inclusion criteria: * patients over 18 years old followed for dystonia and treated with botulinum toxin exclusion criteria: * first dose of botulinum toxin not available
catechin containing mask for the prevention of influenza infection

Conditions: Influenza Infection

Summary: the purpose of this study is to evaluate the effects of catechin extracts containing mask on prevention of influenza infection.

catechins are the major components of tea flavonoids and are reported to possess physiological activities such as antiviral effects. recent in-vitro experimental studies have revealed that tea catechin extracts possess the effects on the prevention of influenza infection. however, a limited number of studies have been conducted on the clinical effects. based on these backgrounds, we designed a prospective randomized controlled study to evaluate the effects of tea catechin extracts containing mask on the prevention of influenza infection.

Eligibility criteria:
inclusion criteria: * possible to wearing mask for three months * possible to fill out a questionnaire personally * obtained written informed consent before participation exclusion criteria: * possessing some infectious diseases in need of therapy * possessing tea or catechin allergy * diagnosed as inadequate for other reasons to participate the study by principal investigator

Keywords: prophylaxis influenza infection catechins prophylaxis of influenza infection
faecal microbiota transplantation as means of preventing recurrent urinary tract infections

Conditions: Recurrent Urinary Tract Infection

Summary: this study investigates faecal microbiota transplantation (fmt) in prevention of recurrent urinary tract infections (utis) caused either by sensitive e. coli or esbl-e. coli.


Eligibility criteria:
inclusion criteria: * female subjects aged ≥18 * history of recurrent uti: at least two episodes of uti over the past 6 months or at least three episodes over the past year, most recent episode within the past three months * written informed consent exclusion criteria: * suspected non-compliance * diagnosis of a gastrointestinal disease * pregnancy * immunosuppression * any kind of permanent urinary catheter or intermittent urinary catheterization * any other criteria which, in the investigator's opinion, would compromise the ability of the subject to participate in the study, the subject's well-being, or the outcome of the study

Keywords: urinary tract infection, faecal microbiota transplantation, esbl, antimicrobial resistance recurrent urinary tract infection uti
a new at-home telerehabilitation care service delivery model for stroke survivors in the rio grande valley

Conditions: Stroke

Summary: the purpose of this study is to investigate the feasibility of a mobile telerehabilitation software for post-acute stroke care for rio grande valley (rgv) stroke survivors with community health worker (chw) at-home support and to estimate the functional health, mental health (depression), and caregiver burden outcomes of this new chw-supported, at-home rehabilitation service delivery model and to identify salient barriers to and facilitators of adopting and delivering the new rehabilitation delivery model to further disseminate the model in real-world communities.


Eligibility criteria:
inclusion criteria: * a resident of the brownsville, texas (cameron county) area * single and first qualifying stroke event with the ability to enroll and begin study activities within 3 months of onset of stroke event * pre-stroke modified rankin score of ≤3 (less than moderate disability at baseline) * currently uninsured * spanish or english speaker * able to follow instructions (without aphasia that interferes with following instructions) * safe to perform basic strengthening rehabilitation exercises * able to stand with or without assistance exclusion criteria: * aphasia or cognitive impairment (e.g., dementia) that interferes with following instructions or prevents following the study-related activities) * pre-stroke motor deficits * current psychiatric disorders, including substance use disorder * underlying brain pathologies inclusive of brain malignancies, multiple sclerosis * insured patients as insured patients are referred for standard-of-care clinical rehabilitation. * medical instability to participate in basic strengthening rehabilitation exercises * inability to access internet from home to access at-home rehabilitation software for intervention arm participants * having received any outpatient rehabilitation services prior to study enrollment for intervention arm participants

Keywords: long-term rehabilitation management stroke survivor telehealth
the effect of vibration application on pain and satisfaction associated with subcutaneous anticoagulation injection

Conditions: Pain

Summary: this study was needed to relieve the pain associated with subcutaneous injection, which is an application performed by nurses, to increase patient satisfaction, to increase patient compliance with treatment, and to strengthen positive patient-nurse communication. the purpose of this study is to assess the effect of vibration stimulation application on subcutan injection induced pain and patient satisfaction. the study will be carried out in the internal medicine service of a university hospital. vibration will be applied during subcutaneous injection of anticoagulant to one group, but not to the other group. it was planned to include 85 patients in the study.

this study was needed to relieve the pain associated with subcutaneous injection, which is an application performed by nurses, to increase patient satisfaction, to increase patient compliance with treatment, and to strengthen positive patient-nurse communication. the purpose of this study is to assess the effect of vibration stimulation application on subcutan injection induced pain and patient satisfaction. the study will be conducted between september 2022 and january 2023 in the internal medicine ward of a university hospital in istanbul/turkey in a prospective, randomized, single-blind, crossover design.two groups will be formed according to the crossover order. volunteers will be informed about the study and their written consent will be obtained. patient evaluation form, visual pain form and satisfaction scale will be applied to all patients before injection. the height, weight and body mass index of the patients will be measured by the specialist nurse. an anticoagulant will be administered subcutaneously over the abdominal region. the areas to be injected will be determined in the same way for each patient. low molecular weight heparin will be administered subcutaneously to the umbilical region with and without vibration, with an interval of 24 hours. all patients will be injected with the same investigative nurse, following the standard procedure. 5 minutes after the application, the pain and satisfaction level of all patients will be evaluated using scales. vibration application will be applied by the researchers for 5 minutes before the injection application.

Eligibility criteria:
inclusion criteria: * volunteers aged 18 and over, * are conscious and have no communication problems, * body mass index (bmi) of 18.5 to 30kg/m2, * who have not had an injection in the last two weeks in the area to be injected subcutaneously, * no signs of skin pain, hematoma, necrosis, scarring, incision or infection at the subcutaneous injection site, * patients treated with subcutaneous heparin injection therapy exclusion criteria: * patients not receiving heparin injection therapy

Keywords: acute pain personal satisfaction injections, subcutaneous