Kornimate/medical-research-clean huggingface dataset:
anterior cervical discectomy and fusion (acdf) - behavioral intervention

Conditions: Dysphagia

Summary: this study will prospectively recruit and enroll patients undergoing primary anterior cervical discectomy and fusion (acdf) surgeries at nyu langone. participants will undergo pre-operative and six-week post-operative swallowing assessment using videofluoroscopy (vfss). acoustic voice samples and patient reported outcome measures (proms) for swallowing and voice will also be collected. beginning one-week before surgery participants will begin a behavioral health program that will be continued for six-weeks after surgery. the primary goal of this study will be to determine whether a preventative behavioral health program improves instrumental measures of swallowing and voice six-weeks after acdf surgery. .


Eligibility criteria:
inclusion criteria: 1. able and willing to sign consent form to participate in the study. 2. age between 21- 99 years. 3. scheduled to undergo acdf surgery with surgeons in the departments of neurosurgery or orthopedic surgery at nyu langone. exclusion criteria: 1. patients with non-degenerative spine conditions, such as trauma, tumors, infection, radiation, and diabetes. 2. patients with prior posterior-approach cervical spine procedures. 3. patients undergoing acdf revision procedures. 4. patients who report a pre-existing dysphagia as the result of a neurological deficit or disorder, head and neck cancer treatment, and/or muscular condition. 5. pregnancy. female subjects must confirm they are not pregnant before enrolling in the study. 6. patients with chronic kidney disease, limiting their ability to consume high levels of protein. 7. patients with known allergies to ingredients listed in premier protein clear drinks.
pharmacokinetic of posaconazole in critically ill patients

Conditions: Therapeutic Drug Monitoring; Critical Illness

Summary: the posaconazole pharmacokinetic in critically ill patients will be studied in a prospective, non-interventional, monocentric observational trial.

the posaconazole pharmacokinetic in critically ill patients will be studied in a prospective, non-interventional, monocentric observational trial. plasma specimens will be retrieved on consecutive days (max. 7 days) in order to measure posaconazole levels during the treatment episode.

Eligibility criteria:
inclusion criteria: * treatment with intravenous posaconazole * critically ill patient * written declaration of consent exclusion criteria: - no declaration of consent
amlodipine versus nifedipine er for the management of postpartum hypertension

Conditions: Hypertension in Pregnancy

Summary: a significant number of pregnancies are complicated by hypertensive disorders. hypertension often worsens in the postpartum period and many women need started on medications. currently, recommended medications for blood pressure management in pregnant and postpartum women are limited, with labetalol and nifedipine er being the most commonly used medications. while these medications are both effective, they are not without limitations. amlodipine is a medication in the same class as nifedipine er. it is a first-line antihypertensive in the general population. it tends to have less side effects than nifedipine er. it has not been studied specifically in postpartum women. the purpose of this study is to determine if amlodipine is noninferior to nifedipine er in managing hypertension in the postpartum period.


Eligibility criteria:
inclusion criteria: * postpartum women with a diagnosis of chronic hypertension, gestational hypertension, or preeclampsia * delivery at or beyond 20 weeks' gestation * need for antihypertensive therapy, defined as blood pressure \>/= 150 mmhg systolic and/or 100 mmhg diastolic on two occasions four hours apart or isolated blood pressure \>160/110 mmhg * english or spanish-speaking * age 18 years or older exclusion criteria: * use of antihypertensive prior to delivery (for any indication) * allergy to nifedipine er or amlodipine * persistent tachycardia (as defined by the treatment team)
genetic diagnosis in inborn errors of metabolism

Conditions: Metabolic Disease; Mitochondrial Diseases; Epilepsy in Children; Epilepsy; LHON; Motor Neuron Disease

Summary: inborn errors of metabolism comprise a large number of rare conditions with a collective incidence of around 1/2000 newborns. many disorders are treatable provided that a correct diagnosis can be established in time, and for many diseases novel therapies are being developed. without treatment, many of the conditions result in early death or severe irreversible handicaps. the centre for inherited metabolic diseases, cmms at karolinska university hospital, is an integrated expert center where clinical specialists work closely together with experts in laboratory medicine, combining clinical genetics, clinical chemistry, pediatrics, neurology, and endocrinology. the center serves the whole swedish population with diagnostics and expert advice on iem and has a broad arsenal of biochemical investigations designed to detect defects in intermediary metabolism.

approximately one in two thousand infants is born with a metabolic disorder that often leads to brain damage. by means of high-tech genetic mapping using whole genome sequencing (wgs), we have discovered the molecular foundations for several of these diseases. for investigation of mitochondrial diseases, mitochondria are isolated from muscle biopsies for analysis of atp production using a range of substrate combinations, determination of activities of respiratory chain complexes, and analysis of nuclear and mitochondrial dna. the center also performs the national neonatal screening program, currently comprising 26 treatable diseases. dried blood spot samples (dbs) are stored in the phenylketonuria (pku) biobank, currently (2024 january) holding around 4.9 million of sweden's 10.6 million inhabitants. many metabolic disorders, however, lack effective counter-measures.

Eligibility criteria:
inclusion criteria: * medical inferral, suspicion metabolic disease incl epilepsy and their relatives exclusion criteria: * disease other than metabolic
immunopathology of polymyalgia rheumatica on shoulder bursae's biopsies

Conditions: Polymyalgia Rheumatica

Summary: the work carried out at the brest university hospital on serum immunological changes in patients with polymyalgia rheumatica (pmr) (based on clinical protocols tenor, semaphore, then) made it possible to describe the changes in the distribution of lymphocyte subpopulations and cytokine levels during ppr, before and then under treatment compared to controls. however, in systemic autoimmune or inflammatory pathologies, serum immunological mechanisms are rarely a reflection of intra-tissue mechanisms. in the specific case of pmr, there are few data concerning muscular or joint immunological modifications. the investigators now wish to study the immunological modifications occurring at the tissue sites of interest, in particular in the shoulder bursae


Eligibility criteria:
for everyone : * signed consent * patients over 50 inclusion criteria : for case patients: * addressed for pmr (diagnosis or relapse) * score greater than or equal to 4 (without ultrasound criteria) or greater than or equal to 6 (with ultrasound criteria), according to the acr / eular 2012 criteria for polymyalgia rheumatica, and suffering from bilateral scapular pain as well as an increased crp level . * thickening of more than 2mm at least one shoulder bursae in ultrasound * das-ppr\> = 10 for witnesses: - shoulder surgery scheduled for mechanical pathology exclusion criteria : for everyone : * mri with gadolinium injection in the previous month- clinical or paraclinical signs of giant cell arteritis * patient under protective measure or unable to consent * active cancer * active infection for the cases: - history of biotherapy treatment for witnesses: * history of inflammatory rheumatism * active inflammatory rheumatism
costs of care and adherence to treatment for cystic fibrosis

Conditions: Cystic Fibrosis

Summary: evolution of medical care for patients with cystic fibrosis appeared in recent years: prolongation of life expectancy with consequently increased comorbidities and the use of lung transplantation, systematic neonatal screening of new born since 2002, prescription of expensive new molecules or new presentation. this evolution justifies to realize an update of statistics of costs of care and to assess adherence to treatment


Eligibility criteria:
inclusion criteria: * patients with cystic fibrosis, * followed by one of the cystic fibrosis center of the rhône-alpes region (pediatric and adult of lyon and grenoble) * affiliated to the general scheme of health insurance, * and domiciled in the rhône-alpes region. exclusion criteria: * transplanted patients
transition from pediatric to adult cystic fibrosis care center

Conditions: Cystic Fibrosis

Summary: the main objective of register-safetim is to assess the impact of the transition from pediatric to adult cystic fibrosis care center on changes in lung function and nutritional status of patients. this is a multicenter, observational, longitudinal, with analysis of the french national registry data of patients with cystic fibrosis. our study will assess the clinical features of adolescent patients with cystic fibrosis during the transition from pediatric care to adult care. it will explore factors associated with the impact of the transition on the clinical course of adolescent patients (respiratory and nutritional functions).


Eligibility criteria:
inclusion criteria: - patients who switched from pediatric cystic fibrosis care center to an adult cystic fibrosis care center during 2013 or 2014, regardless of their clinical status. exclusion criteria: - patients whose transition year is not given in the french national register, that is to say patients from some mixed care center.

Keywords: transitional care teenagers cystic fibrosis pulmonary function nutritional function patients who experiment a transition pediatric - adult care
oxygen reserve index in different fresh gas flow

Conditions: Oxygen Reserve Index

Summary: our primary objective is to determine whether oxygen reserve index ori can be a reliable and sensitive indicator of hypoxia and hyperoxia in low-flow anesthesia settings. our secondary objective is to investigate the ori changes during preoxygenation stage.


Eligibility criteria:
inclusion criteria: * asa i-iii patients * 18-75 years old * underwent general anesthesia * elective ear, nose and throat surgery, lasting longer than 60 minutes exclusion criteria: * who did not consent to participate, * those with finger deformities * unregulated diabetes mellitus, severe heart, kidney, or liver failure, sensitivities to local anesthetics or opioids, those who were morbidly obese (bmi \&gt;40 kg/m²), and breastfeeding women.

Keywords: oxygen reserve index minimal flow anesthesia high flow anesthesia hypoxia hyperoxia
first line gastroesophageal metastatic cancer primary and distant (if oligometastatic) lesions-directed radiotherapy, a multicentric, phase iii, randomized controlled trial

Conditions: Gastroesophageal Cancer (GC)

Summary: the aim of the study is to evaluate the efficacy of radiotherapy on the primary site of gastroesophageal cancer and extracranial stereotactic radiotherapy on metastases before the use of standard systemic therapy, in cases of limited disease burden (in the experimental group), compared to the standard group, which does not receive radiotherapy. this prospective, multicenter, randomized trial aims to evaluate the efficacy of the unconventional approach versus the conventional one in increasing the percentage of asymptomatic patients due to the direct effect of the primary tumor or metastases. "randomized" means that the assignment to one of the treatment groups mentioned above will be random, not influenced by the physician or the patient's condition. therefore, your participation in either of the two treatments under study will be assigned randomly and not predetermined. this randomness is crucial for a proper analysis of the results at the end of the study, which will help clarify whether there are differences between the two proposed treatments. this also means that you may not receive direct benefits from participating in this study, as it is a research study.


Eligibility criteria:
inclusion criteria: * patients diagnosed with gastroesophageal cancer (i.e.: esophagus, gastroesophageal junction, stomach), for both major squamous cell (scc) and adenocarcinomatous (adk) histologies, metastatic, candidate for first-line standard systemic treatment; either newly diagnosed in metastatic stage or first progression to metastasis. * obtaining informed consent. * patients \>18 years of age * ecog 0-2 * performance of imaging (ct with mdc, mri with mdc, ct-pet with appropriate tracer) adequate for baseline local and systemic staging and likely to be similarly repeatable at 6 and 12 months after randomization * confirmation at the time of randomization, by the radiation therapy center, that all potentially planned treatments can be performed for the patient (if enrolled in experimental arm) within a maximum of 25 days total before referral to the medical oncology center for systemic therapy exclusion criteria: * metastatic picture of line following the first * technical or organizational inability to the eventual deadline for radiation treatments within 25 days of randomization * inability to express independent consent to treatments * pregnancy * patient in hospice or with prognosis \< 6 months * predicted unavailability for follow-up at 6 months * absence of adequate or likely non-repeatable pretreatment imaging study at 6 and 12 months * previous radiation therapy * previous radiometabolic therapy * inability to maintain treatment position for sbrt * symptomatic emergent or other presentation precluding study development as planned (e.g., epidural compression of the spinal cord or cauda equina) * previous chemotherapy, immunotherapy or target therapy

Keywords: gastroesophageal cancer metastatic gastroesophageal cancer
the lived experiences measured using rings pilot study

Conditions: Depression; Stress; Sleep; Anxiety

Summary: the transition to college is a period of elevated risk for a range of mental health conditions. for students with pre-existing mental health diagnoses, the added pressures can exacerbate challenges. although colleges and universities strive to provide mental health support to their students, the high demand for these services makes it difficult to provide scalable cost-effective solutions. to address these issues, the present study aims to compare the efficacy of three different treatments using a large cohort of 600 students transitioning to college. interventions were selected based on their potential for generalizability and cost-effectiveness on college campuses. the randomized controlled trial will assign 150 participants to one of four arms: 1) group-based therapy, 2) physical activity program, 3) nature experiences group, or 4) self-monitoring condition as the control group. in addition, biometric data will be collected from all participants using a wearable device to develop algorithmic predictions of mental and physical health functioning. once recruitment is complete, modeling strategies will be used to evaluate the outcomes and effectiveness of each intervention. the findings of this study will provide evidence as to the benefits of implementing scalable and proactive interventions using technology with the goal of improving well-being and success of new college students.


Eligibility criteria:
inclusion criteria: * current undergraduate student in their first year of school * own a mobile device exclusion criteria: * none
endovascular graft anchoring different regions of ascending aorta in the treatment of ascending aortic dissection

Conditions: Ascending Aortic Dissection

Summary: aortic dissection is a deadly and dangerous disease. about 28% of patients with ascending aortic dissection can't tolerate open surgical trauma caused by thoracotomy and cardiopulmonary bypass, and the prognosis is poor. minimally invasive endovascular treatment has been applied in the treatment of descending aortic dissection. however, due to the special anatomical structure and high speed /pressure blood flow, the treatment of ascending aorta dissection has become an international difficulty.

this study was designed combination of retrospective and prospective methods, and focused on distal false lumen aneurysmal expansion of aortic dissection (daead) . to formulate clinical data for the risk assessment of daead, and best intracavitary treatment or long-term efficacy evaluation, we combined the results of genetic testing, evaluating the missense mutation, computer simulation of blood flow dynamics analysis, and clinical imaging analysis.

Eligibility criteria:
inclusion criteria: * aortic dissection diagnosed by cta; * with indications for endovascular treatment * the luminal graft anchor is required to be located in the ascending aorta. exclusion criteria: * import difficult, such as external iliac artery diameter is less than 6 mm bilateral iliac, artery stenosis distortions; * patients with severe comorbidities, such as severe myocardial insufficient blood supply, heart failure, arrhythmia, severe renal dysfunction, and severe blood coagulation dysfunction; * patients with malignant tumor, or other serious illness, life expectancy of less than 1 year； * puncture local infection and high fever;⑤ within 1 month of the large area; * contrast media in patients with cerebrovascular accident or digestive tract hemorrhage patients with allergies; * aortic ulcer or aortic wall hematoma and other atypical dissection.
gown and glove use to prevent the spread of infection in va community living centers

Conditions: Methicillin-Resistant Staphylococcus Aureus

Summary: methicillin-resistant s. aureus (mrsa) infections are a common cause of morbidity and mortality in nursing home residents. mrsa is predominantly spread from patient-to-patient by health care workers. the use of gowns, gloves and hand washing prevents this spread; however, their use detracts from a patient-centered, home-like environment which is an important priority for nursing homes. the goal of this project is to determine when it is most important for health care workers to wear gowns and to wash their hands when caring for mrsa colonized veterans in community living centers.

methicillin-resistant s. aureus (mrsa) infections are a common cause of morbidity and mortality in nursing home residents. mrsa is predominantly spread from patient-to-patient by health care workers. the use of gowns, gloves and hand washing prevents this spread; however, their use detracts from a patient-centered, home-like environment which is an important priority for nursing homes. the goal of this project is to determine when it is most important for health care workers to wear gowns and to wash their hands when caring for mrsa colonized veterans in community living centers. to meet this goal, the investigators will enroll \~400 mrsa-colonized residents and health care workers from va community living centers in four states and the district of columbia. additionally, the investigators will enroll some non-mrsa colonized residents as control subjects. each enrolled resident will be followed for 6-25 episodes of care observations over 30 days. during each observation, the investigators will have health care workers wear disposable gowns and gloves during each care activity (e.g. wound dressing) that occurs during the study visit. at the end of each care activity, the investigators will swab the gown and gloves prior to disposing of them. each swab will be tested for mrsa to determine if mrsa from the resident was transferred to the healthcare worker's gown or gloves during that episode of care. the results of the investigators' analysis will be used to develop new infection control guidelines which balance patient safety and a home-like, patient-centered environment.

Eligibility criteria:
inclusion criteria: resident: * age 18 years * reside in a participating ltcf for rehabilitation, skilled nursing or maintenance care * expected length of stay of \>4 weeks from enrollment * written informed consent from participant, or written informed consent from legally authorized representative (lar) with assent from participant health care worker: * has direct interaction with participating residents at participating va long term care facility (ltcf) * verbal informed consent exclusion criteria: residents: * none health care worker: * unable or unwilling to wear protective gown or gloves during healthcare workers (hcw)-resident interaction

Keywords: cross infection long term care
multimedia based information to parents in a pediatric acute ward: a randomized controlled trial

Conditions: Health Communication

Summary: the aim of this study is to determine whether multimedia based health information presented in a pediatric acute ward to parents of children with breathing difficulties due to lower respiratory tract infections, is more effective than verbal information to reduce the parent's anxiety and to increase satisfaction with nursing care and health information.

the intervention website www.syktbarn.no is an open norwegian online resource for parents of small children, and the site contains videos, audio clips, animations, illustrations, pictures and text materials regarding children's illnesses and normal development. in addition, the parents can use an interactive symptom checker that will help them to decide what to do and when to seek medical advice when their child is sick. the uniqueness of the website is the authentic video clips of sick children with common childhood symptoms like breathing difficulties, signs of dehydration, rash, cough and fever.

Eligibility criteria:
inclusion criteria: * parents of 0-15 years old children with breathing difficulties caused by lrti (bronchiolitis, laryngitis or pneumonia) or asthma exacerbation * ability to communicate and read norwegian exclusion criteria: * parents of children with chronic diseases who have direct access to the acute ward, children with oxygen saturation less than 90 %, or other very sick children who need urgent treatment

Keywords: parents caregivers anxiety consumer satisfaction
effect of barbed suture and triclosan-coated monofilament in emergency surgery

Conditions: Surgical Site Infection

Summary: patients will be randomized 3 groups: group 1: abdominal fascial closure will be performed with triclosan-coated barbed polydioxanone suture group 2:abdominal fascial closure will be performed with triclosan-coated monofilament polydioxanone suture group 3: abdominal fascial closure will be performed with monofilament polydioxanone suture incisional surgical.site infection and evisceration will be recorded.

patients will be randomized 3 groups: group 1: abdominal fascial closure will be performed with triclosan-coated barbed polydioxanone suture (stratafix symmetric, j\&j), caliber 1, 48mm-cylindric needle. group 2:abdominal fascial closure will be performed with triclosan-coated polydioxanone loop suture (pds plus looc, j\&j), caliber 1, 48mm-cylindric needle. group 3: abdominal fascial closure will be performed with polydioxanone loop suture (pds plus looc, j\&j), caliber 1, 48mm-cylindric needle. incisional surgical.site infection and evisceration will be recorded.

Eligibility criteria:
inclusion criteria: * contaminated and dirty surgery * emergency surgery performed by midline laparotomic approach * the following diagnosis will be included: * anastomotic leak of previous digestive surgery (colon, small bowel or gastric surgery) * colonic or bowel perforations * appendicitis with purulent of fecal peritonitis, undergoing midline laparotomy * perforation of gastric or duodenal ulcer * intestinal ischemia requiring bowel resection exclusion criteria: * emergency surgery undergoing laparoscopic approach * appendicitis operated by mcburney incision * intestinal isquemia without requiring bowel resection