Kornimate/medical-research-clean huggingface dataset:
pacepro - mood management pilot

Conditions: Depression

Summary: researchers at the university of california at san diego (ucsd) are conducting a 12-week study to test the pacepro program. this program is designed to reduce depression by providing: lexapro, an antidepressant medicine...learn more physical activity information and pedometer mood management skills and a mood mastery guide personalized support from a family nurse practitioner


Eligibility criteria:
inclusion criteria: * have been diagnosed with mild to moderate depression * are willing to take the antidepressant lexapro * can access and use email and the internet * are willing and able to be physically active * access to a primary care physician exclusion criteria: subjects will be excluded from participation for the following reasons: * pregnancy or breastfeeding * narrow angle glaucoma * any uncontrolled medical condition or any medical condition which would represent a contraindication to escitalopram oxalate lexapro® pharmacotherapy. any concomitant non-psychotropic medications that the physician determines are a contraindication to escitalopram oxalate lexapro® pharmacotherapy bipolar disorder, or any psychotic or organic mental disorder or dementia * history of intolerance or allergy to lexapro, or of prior failed treatment for depression with lexapro * current substance abuse or dependency * current active suicidal ideation * current use of herbal psychoactive treatments such as st. john's wort * concurrent psychotropic medication is not permitted for 2 weeks prior to randomization (4 weeks in the case of fluoxetine) or at any point after * receipt of formal psychotherapy concurrently * inability, in the investigator's opinion, to comply with study procedures or assessments * inability to exercise

Keywords: depression lexapro
a study to test the safety and tolerability of a new medication in the treatment of schizophrenia

Conditions: Schizophrenia

Summary: a 1-year outpatient study to test the safety and tolerability of a new medication in the treatment of schizophrenia

study will evaluate long-term safety and tolerability of a new compound in the treatment of patients with schizophrenia as assessed by adverse events (aes), measures of extra pyramidal symptoms (eps; abnormal involuntary movement scale \[aims\], barnes akathisia scale \[bas\], and simpson-angus rating scale \[sas\]), vital sign measurements, electrocardiograms (ecgs), clinical laboratory evaluations.

Eligibility criteria:
* patients must have participated in study d1050196 (a study to test the effectiveness and safety of a new medication in the treatment of schizophrenia) and either: * successfully completed * or * patients must have been discontinued after a minimum of 2 weeks of treatment due to lack of efficacy

Keywords: schizophrenia latuda lurasidone
intubation success rate_rigid video stylet vs video laryngoscope

Conditions: Intubation, Intratracheal

Summary: this study compare the intubation success rate between video laryngoscope and rigid video stylet in cervical spine surgery patients. half of patients will receive endotracheal intubation by video laryngscope, other half of patients will receive endotracheal intubation by rigid video laryngoscope.

video laryngoscope and lightwand are widely used at endotracheal intubation in cervical spine patients. video laryngoscope is useful because of identification of anatomic structure around the oral cavity and vocal cord. rigid video stylet resemble lightwand, but it has a video at the end of stylet. so rigid video stylet is useful at confirmation of vocal cord.

Eligibility criteria:
inclusion criteria: * 20\~80 years old adult patients, asa class i-iii * cervical spine surgery in general anesthesia exclusion criteria: * patients who did not agree with the study * history of gerd * congenital or acquired lesion like tumor, polyp, trauma, abcess, inflammation, foreign body * surgery of trachea or airway * history of radiation around neck area * increased possibility of aspiration * coagulation abnormality
platelets or fibrinogen as first-line treatment for bleeding during pedatric heart surgery

Conditions: Congenital Heart Disease

Summary: the study aims to test whether platelet transfusion or fibrinogen concentrate is the most effective treatment of intraoperative bleeding, when performing open heart surgery with cardiopulmonary bypass on children with congenital heart defects.


Eligibility criteria:
inclusion criteria: * children \< 1 years of age, scheduled for open surgery of congenital heart defects, using cardiopulmonary bypass. * body weight \< 10 kg. * expected cpb time \> 90 minutes. exclusion criteria: * known coagulation disorder, current treatment with antiplatelet and/or anticoagulant drugs, major surgery the past month before the planned surgery, preoperative kidney or liver failure (defined as creatinine and/or transaminases \> normal interval for the patient´s age), gestational age \< 34 weeks.

Keywords: bleeding coagulopathy heart surgery cardiopulmonary bypass
erector spina plane block in laparoscopic sleeve gastrectomy surgery

Conditions: Obesity

Summary: the aim of the study is to evaluate the effect of erector spina plane (esp) block on pulmonary functions and postoperative analgesic consumption in patients undergoing bariatric surgery.

optimal pain management is very important in obese patients. in the postoperative period, narcotic analgesics are often used to pain management. however, the use of narcotic analgesics in the postoperative period causes many undesirable adverse effects, especially sedation, dizziness, constipation, nausea, vomiting, muscle rigidity, tolerance, and respiratory depression. the morbidly obese patients treated with narcotic analgesics increased risk for adverse effects such as atelectasis, hypoxemia, and postoperative ileus. consequently, these are caused postoperative pulmonary complications, hypoxemia and longer lenght of hospital stay. multimodal analgesia including local and regional anesthesia is recommended for morbidly obese patients. in recent years, the ultrasound (usg) guided esp block has been frequently used to eliminate postoperative pain and reduce narcotic analgesic use. in the literature, it has been shown that bilateral usg guided esp block provides effective analgesia and decrease the analgesia requirements after laparoscopic cholecystectomy. some case series and case reports has also been reported that esp block provides effective analgesia after abdominal and bariatric surgeries. the aim of the study is to evaluate the effect of erector spina plane (esp) block on pulmonary functions and postoperative analgesic consumption in patients undergoing bariatric surgery. for this purpose, asa ii-iii, patients over 18 years of age, bmi 40-60 kg/m2 and elective bariatric surgery planned patients will be included in the study.

Eligibility criteria:
inclusion criteria: * american society of anesthesiology (asa) ii-iii * 18-65 years * body mass index (bmi) 40-60 kg/m2 * elective bariatric surgery exclusion criteria: * asa ≥4 * under 18 years of age or over 65 years of age * declining to give written informed consent * have neurological and/or psychiatric disorders * cooperation cannot be established * accompanying laparoscopic cholecystectomy or paraumbilical hernia repair * history of bariatric surgery * the block cannot be applied due to bleeding disorders or localized skin infection at the injection site * with hepatic, neuromuscular, cardiac and/or renal failure * history of allergy to the local anesthetics * patients undergoing open surgery * patients with severe obstructive or restrictive lung disease

Keywords: erector spina plane block laparoscopic sleeve gastrectomy obesity postoperative pain pulmonary functions
transcutaneous electrical nerve stimulation (tens) for pain control during first trimester abortion

Conditions: Abortion in First Trimester

Summary: high-frequency, high-intensity transcutaneous electrical nerve-stimulation (tens) is an inexpensive and non-invasive pain control approach. tens, pulsating electrical currents that activate underlying nerves, does not have drug interactions or risk of overdose. cochrane review of tens for acute pain found inconclusive evidence. one previous abortion trial comparing tens to iv sedation only looked at pain control in the recovery room. the investigators propose a randomized controlled trial comparing tens to iv sedation (in conjunction with local anesthesia) among women presenting for first-trimester surgical abortion. primary outcome will be perceived pain by visual analogue scale (vas) during aspiration.


Eligibility criteria:
inclusion criteria: * presenting for surgical abortion * gestational age \<12 weeks * \< 18 years of age * agrees to be randomized exclusion criteria: * allergy to study medications (lidocaine, fentanyl, midazolam) * \> 18 years of age * fetal demise * pre-procedure use of misoprostol * no means of transportation following procedure
phase iii randomized study of interferon gamma in children with severe, congenital osteopetrosis

Conditions: Osteopetrosis

Summary: objectives: i. compare the rate of treatment failure in osteopetrosis patients receiving interferon gamma in combination with calcitriol to the rate of treatment failure in patients receiving calcitriol alone. ii. compare the number of adverse events or clinical manifestations of disease progression occurring in these patients. iii. assess the effects of interferon gamma on hematopoiesis, cranial nerve function, and rate of infection in these patients.

protocol outline: this is a randomized, placebo controlled, open label study. patients are randomized to one of two arms (interferon gamma in combination with calcitriol or calcitriol alone). arm i: patients receive calcitriol once daily. interferon gamma is administered by subcutaneous injection three times a week. arm ii: patients receive calcitriol once daily. patients may continue treatment in the absence of toxicity and disease progression. if disease progression is diagnosed in the control group, patients will then receive interferon gamma in combination with calcitriol. patients are followed every 4 weeks.

Eligibility criteria:
protocol entry criteria: --disease characteristics-- * biopsy and x-ray confirmed primary osteopetrosis * presence of anemia and/or cranial nerve compression --prior/concurrent therapy-- * biologic therapy: no prior/concurrent bone marrow transplantation no prior interferon gamma no other investigational biologic agents * chemotherapy: no prior/concurrent chemotherapeutic agents for bone marrow transplantation * endocrine therapy: prior/concurrent corticosteroid as supportive therapy allowed * radiotherapy: not specified * surgery: at least 5 days since major surgery * other: prior/concurrent calcitriol as supportive therapy allowed prior/concurrent transfusion as supportive therapy allowed prior/concurrent dietary therapy allowed --patient characteristics-- * age: 2 months to 10 years * performance status: not specified * life expectancy: at least 6 months * hematopoietic: not specified * hepatic: bilirubin less than 2 mg/dl * renal: creatinine less than 1.5 mg/dl or creatinine clearance greater than 50 ml/min * pulmonary: no uncorrected airway obstruction * other: no active infection requiring intravenous antibiotics no known seizure disorder not related to hypocalcemia no uncorrected hydrocephalus no mri evidence of cerebral atrophy must maintain or gain body weight no sleep apnea no thrombocytopenia no massive splenomegaly

Keywords: genetic diseases and dysmorphic syndromes osteopetrosis rare disease
virtual reality based physical therapy for patients with lower back pain

Conditions: Chronic Low-back Pain

Summary: the goal of this clinical trial is to compare chronic low back patients. the main question\[s\] it aims to answer are: * pain and disability * fear avoidance belief participants will perform virtual reality exercises * virtual reality based exercises * routine physical therapy to compare routine physical therapy treatment in addition to virtual reality to see effects on pain, functional disability and fear avoidance belief


Eligibility criteria:
inclusion criteria: * low back pain that persists for more than 12 weeks * non-radiating low back pain * mechanical low back pain * both gender exclusion criteria: * trauma or fracture of the spine * any cardiac disease * any systematic disease * history of any neurological diseases such as parkinson's disease, stroke and epilepsy * patient on corticosteroid or anticoagulants * history of any drug abuse * any congenital deformity * virtual reality games phobia * pregnant female

Keywords: low back pain chronic low back pain virtual reality
physical exercise in patients with schizophrenia

Conditions: Schizophrenia; Physical Activity; Telomere Shortening; Premature Aging

Summary: randomised clinical trial on a cohort of subjects with a diagnosis of schizophrenia of legal age, of both sexes, recruited in the mental health clinics of the salamanca university assistance complex and who will be randomly distributed into two groups (intervention and control). the main objective of the study is to determine the effect of physical exercise on telomere size in patients diagnosed with schizophrenia. as secondary objectives in this group of patients we will try to: evaluate the influence of strength training on cognition and negative symptoms of schizophrenia. to quantify the impact of strength training on frailty. to determine the effect of strength training on quality of life. to study the possible correlation between physical parameters (frailty) and telomere length. to establish the importance of polymorphisms in telomerase genes, an enzyme involved in the maintenance of telomere length.


Eligibility criteria:
inclusion criteria: * be at least 18 years of age * have been diagnosed with schizophrenia for at least 5 years exclusion criteria: * are unable to read and understand the patient information sheet and sign the informed consent form.
dims-myopia progression adn axial length growth

Conditions: Myopia, Progressive

Summary: to confirm the efficacy of dims lenses in controlling myopia progression, we planned a prospective randomized controlled clinical study.

the subjects were randomly assigned into two groups: the control group (sv) and the experimental group (dims). the clinical trial assistant took the glasses before examination and returned them after examiners had performed all tests. examiners were unaware of the spectacle type until the end of the follow-up period. however, the lens type was known by children and parents since the unique appearance of the dims lens. the subjects were provided details about the study design and methodology and their rights as subjects at first visit. we conducted visual acuity tests, subjective and objective refraction measurements, al measurements, heterophoria at distance and near, and accommodation after obtaining written informed consent from them and their parent. we conducted follow-up examinations 6 and 12 months after the first visit. in the follow-up examinations, we measured all the examination as do ate the firt visit. either the va with the current spectacles dropped to \< 0.8(20/20) or se of cycloplegic subjective refraction increased ≤-0.50d, the lens power of the spectacles was replaced on the basis of the cycloplegic subjective refraction.

Eligibility criteria:
inclusion criteria: * the subjects had spherical re of -1.00 to -6.50 d, astigmatism ≤ 4.00 d, anisometropia ≤ 1.50 d * best corrected visual acuity (bcva) equal to or better than logmar 0.0 (20/20) in both eyes. exclusion criteria: * candidate subjects were excluded from the study if they had strabismus, ocular limitations, or systemic abnormalities affecting vision and ocular motility.

Keywords: myopia axial length dims
hospital versus home based exercise in patients with chronic stable heart failure

Conditions: Congestive Heart Failure

Summary: the objective of this study is to compare the effect of monitored, home-based exercise versus hospital-based exercise on the quality of life of patients with congestive heart failure. secondary objectives are to assess the effect of the intervention on exercise capacity and caregiver burden. the investigators hypothesize that the exercise training in the home-based environment will be superior to hospital based exercise training.

congestive heart failure (chf) is a chronic disease that is associated with enormous burden of illness. patients with chf have diminished health-related quality of life, and due to the high demand associated with their everyday activities and self-management, there is consequently a burden upon family caregivers. though exercise is a component of clinical practice guidelines for the management of chf, previous studies have not examined the interrelationships among changes in exercise capacity, health-related quality of life (hrql) and important predictor variables such as self-efficacy, as a result of exercise training in chf patients. furthermore, research to date has failed to examine whether a hospital-based or a home-based approach to exercise is the best-suited strategy for long-term adoption and benefit from exercise training. thus, the most important effective approach to, and environment for, exercise training to improve the health and self-management of chf patients has not yet been determined. this study will address some important gaps in the existing literature related to the benefits of exercise in chf, specifically how different exercise approaches and strategies contribute to an individual's hrql and self-efficacy. this is a prospective, randomized controlled trial using a two-group, repeated measures design. male and female patients with new york heart association (nyha) functional class i-iii chf will be eligible to participate. participants will be randomized to receive either supervised, hospital-based exercise or monitored home-based exercise. the participants in the study will train for a period of six months and will be reassessed six months following completion of the intervention to assess sustainability of any observed changes.

Eligibility criteria:
inclusion criteria: * chronic stable heart failure * nyha class i, ii or iii * willing and able to regularly attend a supervised exercise program * provision of written, informed consent exclusion criteria: * unstable angina in the last month * recent acute mi (last 3 months) which precipitated heart failure * hospitalized for heart failure in past month * severe chronic pulmonary disease (fev1 \<40%) * uncontrolled hypertension (b/p \>140/90) * orthopedic, neurological or psychiatric illness precluding participation in exercise * heart failure that is amenable to revascularization, which is planned in the near future * nyha class iv

Keywords: heart failure health related quality of life exercise capacity home based exercise training supervised exercise training
safety and efficacy of a retinoid for the treatment of severe chronic hand dermatitis

Conditions: Hand Dermatoses

Summary: patients with severe chronic hand dermatitis, that has not responded to topical treatment, including topical steroids and the avoidance of aggravating factors, will be treated with the oral medication alitretinoin. the study aims to investigate the safety and efficacy of the medication when given over a period of 6 months.

for severe, chronic hand dermatitis, refractory to topical treatment and the avoidance of aggravating factors such as allergens and irritants, no registered systemic treatment is available. current systemic treatment options consist in the off-label use of systemic immune suppressants, such as cyclosporine, methotrexate. severe chronic hand dermatitis is a debilitating disease, with massive impact on social life and working ability. a huge proportion of the population suffers for more than a decade, and job losses are a frequent consequence. this open-label trial investigates the safety and efficacy of oral alitretinoin 30mg as a single daily dose for up to 6 months. the trial is complementary to the pivotal efficacy study bap00089.

Eligibility criteria:
inclusion criteria: * chronic hand dermatitis, rated as severe by physicians global assessment, present for at least 6 months, that has not responded to the avoidance of allergens and irritants and the use of topical steroids exclusion criteria: * female of childbearing potential, unless participating in a pregnancy prevention program * psoriasis * active major psychiatric condition

Keywords: hand dermatoses, hand dermatitis hand eczema chronic hand dermatitis retinoid
study to describe the allergic reactions to factor ix in patients with hemophilia b

Conditions: Hemophilia B; Allergic Reactions

Summary: retrospective, multicenter study in patients with hemophilia b. this study will be placed at 20 to 50 hemophilia treatment centers in north america and the eu, and is designed to estimate the frequency of class ii and iii allergic reactions in association with the administration of any fix concentrate. following informed consent and eligibility, historical patient information including demographics, allergy history, hemophilia history, frequency and severity of allergic reaction(s), number of exposure days with products causing allergic reactions, exposure days to blood products including fix concentrates, treatment for allergic reaction(s), outcome of event(s), any other adverse event(s) occuring within 48 hours of onset of allergic reaction(s), rechallenge and outcome, switch to another fix product (if applicable) and outcome, current status of patient, and results of any special studies (eg, skin or rast testing, alloantibody analyses, ect) will be collected.


Eligibility criteria:
inclusion criteria: * written consent to release patient information * living or deceased patients with mild to severe hemophilia b who have had at least 1 exposure to replacement factor ix product(s). * living or deceased patients who had their first infusion of any fix product between 1 january 1991 and 31 december 2003. exclusion criteria: * there are no exclusion criteria.

Keywords: hemophilia b
pharmacodynamic study of cilostazol in healthy volunteers

Conditions: Healthy

Summary: the primary objective of this study is to investigate the effects of cilostazol, acetylsalycylic acid and clopidogrel alone as well as combinations of cilostazol/acetylsalicylic acid and cilostazol/ clopidogrel on ex-vivo platelet function (pf) testing.


Eligibility criteria:
inclusion criteria: * healthy caucasian male subjects * able to read, to write and to fully understand german language * provision of written informed consent before screening and baseline * bmi between 19.0 and 30.0 kg/m2, inclusive and body weight between 50.0 and 100.0 kg, inclusive * good general health as determined by the investigator by medical history, physical examination, vital signs, electrocardiogram, baseline and safety lab exclusion criteria: * personal or family history of bleeding disorders, or reasonable suspicion of vascular malformations, including aneurysms * known predisposition to bleeding (e.g. active peptic ulceration, recent (within 6 month) haemorrhagic stroke, proliferative diabetic retinopathy, poorly controlled hypertension) * use of antibiotics within thirty (30) days prior to screening and until baseline visit * clinically significant abnormalities in medical history, physical examination, vital signs, electrocardiogram, baseline and safety lab * supine pulse rate \> 100 beats/min or \<50 beats/min * systolic blood pressure \ 140 mmhg * diastolic blood pressure \ 90 mmhg * concomitant use of any other medication including over-the-counter preparations

Keywords: healthy volunteers