Kornimate/medical-research-clean huggingface dataset:
nordic walking for individuals with osteoporosis, vertebral fracture or hyperkyphosis

Conditions: Osteoporosis; Hyperkyphosis; Vertebral Fracture

Summary: nordic walking is currently offered by a number of health care practitioners as a form of exercise therapy for older adults at risk of fracture. these include older individuals with osteoporosis, previous vertebral fracture, or hyperkyphosis. to the investigators knowledge, this practice is not evidence-based and thus potentially problematic as benefits and safety of nordic walking for individuals with osteoporosis, fractures, or hyperkyphosis are unknown. the proposed study will answer the following principal question: does nordic walking improve mobility, physical function, posture, and quality of life for ambulant community dwelling individuals who have osteoporosis, a history of osteoporotic fracture, or hyperkyphosis? participants will be randomized into either the nordic walking intervention group, or the waiting-list control group. participants will initially train 3 times per week for 3 months, led by peer- and/or student-instructors. the nordic walking training will depend on the participant's skill and comfort level and will consist of walking with poles over a distance set individually for each participant. the control group will receive the same 3-month nordic walking intervention after their control follow-up measurements are completed.

the investigators will include 160 individuals who have been diagnosed with osteoporosis, have history of osteoporotic fracture or hyperkyphosis (hunched-back posture). participants will be randomized to either a nordic walking intervention group or a waiting-list control group (the latter group will receive same intervention after the trial is completed). the pole-walking intervention will be 12 weeks in duration, including 3 weekly nordic walking sessions (warm up, nordic walking with posture and leg strengthening exercises and stretches) tailored to each participants. the investigators will define osteoporosis status at baseline (via dxa scans). the investigators will compare between group changes in dynamic balance, posture, quality of life, mobility, muscle strength, size and composition (using low radiation ct scans) after 3 months of nordic walking intervention.

Eligibility criteria:
eligibility criteria for study participants: * diagnosis of osteoporosis, past vertebral fracture or hyperkyphosis * ambulatory (without the use of assistive devices) * not currently involved in moderate-vigorous exercise training, including nordic walking, more than once per week * must not be diagnosed with parkinson's disease

Keywords: nordic walking osteoporosis hyperkyphosis vertebral fracture
effectiveness, safety and clinical outcomes of elbasvir/grazoprevir: results from a spanish real world cohort

Conditions: Hepatitis C

Summary: this is a multicentre, descriptive, observational and ambispective study carried out in patients who are treated with elbasvir/grazoprevir in hospitals that included their data in hepa-c registry (directed by the spanish association for the study of the liver and the networked biomedical research centre for hepatic and digestive diseases).

this is a multicentre, descriptive, observational and ambispective study carried out in patients who are treated with elbasvir/grazoprevir in hospitals that included their data in hepa-c registry (directed by the spanish association for the study of the liver and the networked biomedical research centre for hepatic and digestive diseases)

Eligibility criteria:
inclusion criteria: * age: 18 years to 100 years (adult). * sexes: all * healthy volunteers: no * chronic hepatitis c (anti-hcv antibodies and detectable hcv-rna). exclusion criteria: -

Keywords: hepatitis c
effects of acute prucalopride administration in healthy volunteers

Conditions: Molecular Mechanisms of Pharmacological Action; Depression; Depressive Disorder; Mood Disorders; Mental Disorder; Antidepressive Agents; Cognition

Summary: this study will investigate whether administration of a single dose of the serotonin receptor subtype 4 (5-ht4) partial agonist prucalopride has effects on emotional processing and non-emotional cognition in healthy volunteers, compared to placebo administration. using an experimental medicine approach, the effects of prucalopride on cognitive biomarkers of antidepressant action will be characterised. in a double-blind design, participants will be randomised to receive a single dose of either prucalopride (1mg) or placebo. all participants will come for a screening visit to ensure their suitability for the study. if they meet study criteria, they will be invited to a research visit, where they will receive the study medication and wait for two hours while the drug reaches peak levels. after two hours they will be asked to complete a series of computer-based tasks measuring emotional, non-emotional cognitive processing, and reward processing. the primary study hypothesis is that acute prucalopride administration will have positive effects on processing facial expressions of emotion. secondary hypotheses are that acute prucalopride administration will affect other measures of emotional processing, and non-emotional cognition.


Eligibility criteria:
inclusion criteria: * male or female * aged 18-40 years * willing and able to give informed consent for participation in the study * sufficiently fluent english to understand and complete the task exclusion criteria: * current usage of psychoactive medication (except the contraceptive pill, the depo-provera injection or the progesterone implant) * any past or current axis 1 dsm-iv psychiatric disorder * significant medical condition * current or past gastro-intestinal disorder or irritable bowel syndrome * current pregnancy or breastfeeding * known lactate deficiency or any other problem absorbing lactose, galactose or glucose * current or past history of drug or alcohol dependency * participation in a psychological or medical study involving the use of medication within the last 3 months * previous participation in a study using the same, or similar, emotional processing tasks * smoker \> 5 cigarettes per day * typically drinks \> 6 caffeinated drinks per day

Keywords: 5-ht4 prucalopride resolor emotional processing healthy volunteers
ibritumomab tiuxetan (zevalin)+ rituximab maintenance

Conditions: Non-Hodgkin's Lymphoma

Summary: subjects will receive the ibritumomab tiuxetan (zevalin) therapeutic regimen; then rituximab consolidation and maintenance therapy every 3 months until disease progression

the objective of this study is to estimate the median progression-free survival for patients receiving this regimen, along with the rate of complete response at 6 months, toxicities associated with this regimen, and laboratory correlates. subjects will receive the ibritumomab tiuxetan (zevalin) therapeutic regimen; then rituximab consolidation and maintenance therapy every 3 months until disease progression.

Eligibility criteria:
inclusion criteria: * patients with biopsy-proven non-hodgkins lymphoma of follicular grade 1, 2, or 3 * meeting flipi criteria for intermediate or high risk. * no prior chemotherapy, radiotherapy or immunotherapy for lymphoma; * patients may not have known hiv infection, and must not be hepatitis b surface antigen positive. exclusion criteria: * may not be pregnant or breastfeeding, have documented cns (central nervous system) disease, g-csf (granulocyte colony stimulating facto) or gm-csf (granulocyte/macrophage colony stimulating factor) within 2 weeks prior

Keywords: zevalin, high tumor burden indolent non-hodgkin's lymphoma, ibritumomab tiuxetan
anterior tibiotalar arthrodesis with blade plate fixation

Conditions: Pilon Fracture; Arthritis

Summary: the aim of this study is to evaluate the clinical and radiographic outcomes of patients who have previously undergone tibiotalar arthrodesis using an anterior approach with blade-plate fixation for tibiotalar arthritis secondary to injury to the articular surface of the distal tibia.


Eligibility criteria:
inclusion criteria: * all patients whom have undergone anterior ankle arthrodesis with a blade plate construct, performed by a single surgeon, between january 2003 and july 2011 at the university of utah or primary childrens medical center (pcmc) will be eligible for inclusion. exclusion criteria: * any patient who is not 18 years of age or older will not be eligible for the study.
predictors of hospital readmission for chronic obstructive pulmonary disease patients

Conditions: Hospital Radmission for COPD Patients

Summary: this study is aimed to determine the risk factors for hospital readmission within 6 months in copd patients

this study is aimed to determine the risk factors for hospital readmission within 6 months in copd patients and develop early warning model

Eligibility criteria:
inclusion criteria: * all copd patients of both genders diagnosed by (gold) guidelines (2024 revision). * cooprative patients who accept to participate in the current study . exclusion criteria: * patients with cognitive impairment ,and unable to answer needed questions. * patients with other lung diseases such as active pulmonary tuberculosis ,asthma ,bronchiactesis,and pulmonary embolism . * patients with incomplete clinical data . * refused to participate in the current study .
evaluating materials to educate patients about cervical dysplasia

Conditions: Education; Cervical Dysplasia

Summary: primary objective: to pilot test high and low literacy patient education materials for colposcopy clinic patients, assessing impact on patient knowledge and patient feedback about the materials.

women with an abnormal papanicolaou (pap) smear are typically referred for a colposcopy and biopsy. however, data collected by research groups and others shows that women with abnormal pap smear results have limited understanding of the meaning of the results, the causes of cervical dysplasia, and the procedures used to evaluate and treat it. this situation is further complicated by the fact that many patients, particularly those with less education, have low health literacy in general. this means that much of the existing patient education materials will likely be inappropriate or ineffective for this group. one approach is to develop materials at low literacy levels; however, it is not known whether such materials will be provide sufficient information and be effective for patients with high health literacy. the long term goal is to study the importance of tailoring patient education materials to colposcopy patients' level of health literacy. to this end, researchers have developed two educational brochures with approximately the same information, but which vary in their health literacy (readability) level. as a first step in this research, researchers propose to present these materials to colposcopy patients returning for colposcopy visits to assess changes in knowledge and obtain patient feedback on the brochures. the proposed pilot study represents the first step at evaluating the patient education materials and determining the patient's level of understanding of what they receive.

Eligibility criteria:
inclusion criteria: 1. over 18 years old; 2. follow up colposcopy clinic patients who completed a colposcopy and treatment (if indicated) at an earlier date; 3. able to communicate in english exclusion criteria: none

Keywords: patient education cervical dysplasia questionnaire
the effect of bevacizumab on the trabeculectomy

Conditions: Glaucoma

Summary: the investigators plan to evaluate the additive effect of intracameral and subconjunctival injections of bevacizumab in trabeculectomies with other antimetabolites.

glaucoma filtration surgery is routinely utilized to control intraocular pressure in glaucomatous patients. it reduces iop by creating a fistula between the anterior chamber and the subconjunctival space with a filtering bleb. increased wound healing response affects the function and morphology of the filtering bleb, and wound healing involves a series of biological events beginning with hemostasis. corticosteroids and antifibrosis agents such as mitomycin c and 5-fluorouracil have been employed in trabeculectomy to delay wound healing and hence to improve the success rate of surgery by inhibiting inflammation and fibroblastic activity, and the use of these antiscarring agents is generally believed to improve the success rate of trabeculectomy.but this rate decreased with passing time and thus was not perfect. vascular endothelial growth factor is a pivotal stimulator of angiogenesis because its binding to vegf receptors has been demonstrated to promote endothelial cell migration and proliferation in wound healing.therefore, anti-vegf agents may potentially modulate wound healing following glaucoma filtration surgery. the principal objective of this study was to evaluate the additive effect of intracameral and subconjunctival injections of bevacizumab in trabeculectomy.

Eligibility criteria:
inclusion criteria: * glaucoma patients who have trabeculectomy exclusion criteria: * patients with the other ocular disease

Keywords: trabeculectomy
covid-19 related financial hardship and distress in women who decline tmist (ea1151) participation

Conditions: Breast Cancer, NOS

Summary: the purpose of this study is to find out whether factors that lead women of color to decline participation in the breast cancer screening trial ea1151 (tmist) differ from non-women of color.

in a population of women who decline participation in tmist (eaq201 participants), we will compare the proportion of woc vs non-woc with respect to who experience covid-related financial hardship, a composite endpoint defined as any psychological response (financial distress, food/housing insecurity) or change in their material condition. we hypothesize that covid-19 related financial hardship and distress are more prevalent in woc who decline tmist participation compared to non-woc who decline participation.

Eligibility criteria:
inclusion criteria: participants must be women age 45 or older and under age 75 at the time of study entry. participant must be scheduled for, or have intent to schedule, a screening mammogram. participant must be eligible for ea1151/tmist. participant must have declined participation in ea1151/tmist. participant must be able to complete questionnaires in english. participant must have a u.s. zip code. exclusion criteria:
comprehensive cbt (cognitive behavioral therapy) via reset app

Conditions: Addiction; Opioid-use Disorder

Summary: this research is being done to find out whether an app based cognitive behavior therapy called reset improves the adherence to and outcome of buprenorphine treatment for opioid use disorder (oud) in the setting of a hub and spoke implementation system.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * starting outpatient treatment for oud within the pacmat hub and spoke system (either the hub or one of the spokes) * planning maintenance treatment with buprenorphine * willing to participate in the study * can read, write and comprehend english exclusion criteria: * planning an outpatient detoxification, or treatment other than buprenorphine maintenance (e.g. methadone maintenance, vivitrol, or counseling with no medication) * judged by the evaluating physician or allied clinician to need a higher level of care (e.g. residential or inpatient treatment) * unwilling to participate in the study * under the age of 18 * unable to read, write and comprehend english
cryoballoon pulmonary vein isolation including associated esophageal effects

Conditions: Paroxysmal Atrial Fibrillation

Summary: to determine the correlation between rate of temperature decline and nadir cryoballoon temperatures rate of temperature decline and nadir esophageal temperatures during pulmonary vein isolation.

when treating atrial fibrillation and targeting various areas in the left atrium, electrophysiologists have the choice to perform ablation with rf energy or cryoenergy. esophageal ulceration and in more rare cases, esophageal fistulae, are known complications of this ablation procedure. though rare (0.1-0.25% fistula rate and 15-20% esophageal ulceration rate according to the most recent heart rhythm society ehra eca consensus statement)1, the investigators would very much like to understand how to completely prevent these occurrences. cryoenergy has more recently been introduced as an energy source used in the pvi procedure; therefore, for this energy source, rates of esophageal ulceration are not yet well-defined. nine esophageal fistulae have occurred in the first approximately 130,000 cryoballoon procedures.

Eligibility criteria:
inclusion criteria: 1. recurrent, symptomatic, drug-refractory, paroxysmal atrial fibrillation with planned cryoballoon pulmonary vein isolation 2. age \>18 years 3. planned af cryoablation procedure exclusion criteria: 1. la diameter \>55mm 2. severe lvh (lv wall ≥ 15mm) 3. la thrombus 4. decompensated heart failure 5. plans for left atrial ablation lesions beyond isolation of the pulmonary veins 6. history of previous pulmonary vein isolation 7. inability to place esophageal temperature probe or tee probe 8. previously documented phrenic nerve injury 9. known esophageal pathology (complete gi history worksheet)

Keywords: cryoballoon pulmonary vein isolation esophageal effects
exploratory study of norepinephrine to prevent radiodermatitis in breast cancer patients

Conditions: Radiodermatitis

Summary: this study, a nonrandomized open-label phase i safety and exploratory study, will evaluate the safety of topical norepinephrine in post-surgical breast cancer patients who are undergoing radiation therapy. the study will also provide information about whether topical norepinephrine can prevent or decrease the severity of the radiation dermatitis experienced by these patients.


Eligibility criteria:
eligibility criteria subjects must: * be ≥ age 18 years of age with a documented pathological diagnosis of stage ia (t1, n0, m0), stage ib (t0 or 1, n1mic, m0) or stage iia (t\<3cm, n0, m0) infiltrating ductal or lobular carcinoma of the breast or ductal carcinoma in situ (dcis). * be post-surgical patients scheduled to be treated with at least 40 to 50.4 gy to the whole breast and axilla using either standard or hypofractionated radiation techniques . an additional 10-16 gy boost to the lumpectomy region may also be delivered. all radiation treatment is to be delivered based on standard ct planning. * have the ability to understand the informed consent document. * be able to comply with protocol schedule. * have a negative serum pregnancy test (within 7 days prior to starting radiation therapy), if a female of child bearing potential. * consent to utilize medically acceptable methods of contraception throughout the study period if of child-bearing potential. exclusion criteria subjects: * with unhealed surgical wounds or scars in the study treatment area (axilla). * with underlying active untreated cardiac disease (e.g. arrhythmia). * with generalized skin disorders that have required treatment within the past 6 months. * with connective tissue disorders. * with rashes, ulcerations, or poorly healed scars in the study drug application area (axilla). * with a known allergy to norepinephrine. * with known uncontrolled hypertension (repeatedly elevated bp; systolic bp \>139 or diastolic bp \>89). * with a known clinically significant abnormal ecg within the past 6 months. * receiving mao inhibitors or antidepressants (triptyline or imipramine types). * who are pregnant or breastfeeding. * with lymphovascular space invasion on pathology. * with dermal lymphatic invasion on pathology. * with proximity of the tumor to the overlying skin as evidenced by a distance of less than 5 mm on us or mri (if performed) and within 2 cm of the anticipated application field * diagnosis of inflammatory breast cancer. * receiving chemotherapy other than herceptin concurrent with the radiation. * with previous radiation to the breast to be treated.

Keywords: radiodermatitis prevention radiotherapy breast radiation dermatitis
evaluation of antimicrobial potency of garlic lemon extract irrigant versus physiological saline irrigant

Conditions: Necrotic Primary Teeth

Summary: to evaluate the antimicrobial potency of garlic lemon extract irrigant versus physiological saline irrigant following partial pulpectomy in primary molars.

pulpectomy is a suitable treatment of primary teeth with irreversible pulpitis, necrosis, or periodontitis due to caries or trauma. due to the complex nature of the deciduous root canal system makes total removal of necrotic tissue by instrumentation alone impossible. therefore, irrigation is a replenishing step to create a disinfectant atmosphere inside the root canal. a variety of antiseptic and antibacterial irrigating solutions have been used such as (naocl), (chx), and (edta). due to their adverse effects, safety issues and cytotoxic reactions, herbal products can be an alternative to these irrigants based on their previous history in medical field. herbal extracts such as garlic (allium sativum) shows a wide range of therapeutic effects due to the presence of allicin, ajoene \& other thiosulfinates. it has antibacterial effect against wide range of gram-positive and gram-negative bacteria, anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, immunomodulatory effects and tissue-dissolving capacity (siddique, et al., 2020). according to (elheeny., 2019) allium sativum extract can be used efficiently as an irrigant for pulpectomy of primary molar root canals. lemon (citrus limon) as well has curative properties such as, antibacterial, antiviral, antifungal, anti-inflammatory, anti-cancerous activities and removal of the smear layer as well. due to presence of ascorbic acid, phenolic acids, polyphenols, and dietary fibers. the combination of garlic-lemon has been tested in adult teeth as an irrigant and showed an effective result equal to naocl (siddique, et al., 2020).however, there is no studies have been performed to assess the combination of garlic-lemon extract as an irrigant in deciduous molars.

Eligibility criteria:
inclusion criteria: 1. the children's age range from four to seven years from both sexes. 2. presence of localized swelling, sinus and pain on percussion which indicate non vital pulp. 3. presence of periapical and furcation radiolucency in periapical radiograph. 4. absence of history of systemic disease which would contraindicate pulp therapy e.g. infective endocarditis. 5. no previous history of antibiotics administration or last dose was taken from at least two weeks. exclusion criteria: 1. presence of advanced physiologic or pathologic root resorption in x-ray. 2. uncooperative children. 3. teeth with unrestorable crowns. 4. teeth with abnormal anatomy and calcified canals.