Kornimate/medical-research-clean huggingface dataset:
adaptive treatment for adolescent anorexia nervosa

Conditions: Eating Disorder; Anorexia; Anorexia Nervosa; Anorexia in Adolescence; Anorexia in Children; Anorexia Nervosa Restricting Type; Anorexia Nervosa, Atypical; Eating Disorders in Adolescence

Summary: the investigators are conducting a randomized controlled trial using an adaptive design for adolescents (ages 12-18) with anorexia nervosa to compare standard family based treatment (fbt) to adaptive fbt with an intensive parental coaching (ipc) component. if participants do not reach expected milestones by session 4 of treatment, participants may be randomized to receive additional ipc or continue treatment as usual with regular fbt.

potential subjects aged 12 to 18 with anorexia nervosa (an) will be recruited from stanford university, university of california, san francisco, other bay-area medical programs and clinics, and online advertisement to the population at large. if participants are deemed eligible, participants will be invited for a baseline interview (about 2 hours in duration) during which the investigators will conduct interviews and collect questionnaire measures. then, participants and participants' families will begin family based treatment (fbt) with a study therapist at stanford university or university of california, san francisco, respectively. all assessments and treatments are conducted through tele-health. at session 4, if participants have not gained 2.4kg, an indicator of early treatment response, participants and participants' families will be randomized to receive either treatment as usual (fbt) or an adaptive form of fbt, during which families will receive additional intensive parental coaching (ipc). if participants have reached weight milestones (i.e., 2.4kg at session 4), participants will continue fbt as usual. at 3 months of treatment and end of treatment, the investigators will collect the same measures taken at baseline. the investigators also ask that families participate in 6- and 12-month follow-up, respectively.

Eligibility criteria:
inclusion criteria: * 12-18 years of age and living with participants' families * meeting dsm-5 criteria for an (both subtypes) except for the amenorrhea requirement * medically stable for outpatient treatment according to the recommended thresholds of the american academy of pediatrics and the society of adolescent medicine. exclusion criteria: * associated physical illness that necessitates hospitalization * psychotic illness, mental retardation, or any other mental illnesses that would prohibit the use of psychotherapy * current dependence on drugs or alcohol * physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight * previous fbt * currently taking medication for co-morbid disorders that cannot be safely discontinued on a stable dose for less than 2 months * in the case of patients with current, or a history of sexual or physical abuse by family members, perpetrators of the abuse will be excluded from treatment.

Keywords: anorexia anorexia nervosa eating disorder weight eating weight loss family based treatment fbt family treatment therapy maudsley method
pazopanib maintenance for sclc

Conditions: SCLC

Summary: to evaluate the efficacy of pazopanib maintenance after 1st line ctx for sclc.


Eligibility criteria:
inclusion criteria: * histologically confirmed sclc * no disease progression after 4 cycles of etoposide/platinum 1st-line therapy * history of 4 cycles of etoposide/platinum 1st-line therapy * between 21 days and 42 days since c4d1 of etoposide/platinum * no symptomatic brain meta exclusion criteria: * poor hepatic, renal function

Keywords: pazopanib maintenance efficacy sclc
maternal-fetal outcomes of genital blood loss beyond 18 weeks of pregnancy

Conditions: Blood Loss

Summary: the primary objective is to assess in terms of frequency the adverse outcomes (premature birth, maternal-fetal haemorrhage, maternal fetal-neonatal death) of pregnancies of women attending the obstetric-gynaecological emergency department for genital bleeding beyond the 18th week of pregnancy.

the investigators decided to conduct this study because it is important on the one hand to carefully evaluate maternal-fetal outcomes in pregnancies characterised by genital bleeding in the second and third trimesters and on the other hand to evaluate the sonographic diagnostic capacity for identifying the aetiology of these genital bleedings, in order to understand whether the possibility of identifying a specific cause of the bleeding has also improved over time as sonographic techniques have improved. this could then allow management and subsequent obstetrical controls to be adapted in a more accurate and indivudualised manner. for the purpose of this study, no study-specific visits are planned. data collected during pregnancy and delivery data for patients who gave birth at our centre will be analysed.

Eligibility criteria:
inclusion criteria: * pregnancy beyond 18 weeks gestational age complicated by genital bleeding; * age of the patient ≥18 years; * delivery at the o.u. of obstetrics and prenatal age medicine exclusion criteria: none

Keywords: pregnancy blood loss
visual rehabilitation of patients with myopic maculopathy

Conditions: Myopic Maculopathy

Summary: the visual pathfinder (lace inc.) offers a non- invasive, patient- centered visual rehabilitation system based on an acoustic biofeedback. the investigators wanted to evaluate its usefulness in the improvement of visual function in visually impaired patients with high myopia.


Eligibility criteria:
inclusion criteria: * high myopia (range 9-15 d) visited at the outpatient medical retina's hospital a. fiorini terracina (lt), university of rome "la sapienza", polo pontino. the diagnosis of myopic maculopathy was made on the basis of a comprehensive ophthalmological evaluation which included: biomicroscopic examination of anterior and posterior segment, fluorescein angiography (fag) (heidelberg hra-2, fa module heidelberg, germany), optical coherence tomography (oct), spectral domain (heidelberg hra-2, oct module heidelberg, germany) and microperimetry with microperimeter mp-1 (nidek technologies, padova, italy). exclusion criteria: * the investigators have excluded patients with other eye diseases (glaucoma, amd, retinal detachment, etc.), uncooperative patients and persons with opacity of the dioptric media.
comparison of three surgical techniques to achieve patella symmetry during resection

Conditions: Arthroplasty, Replacement, Knee; Injuries, Knee

Summary: this research was performed to determine which of the three techniques used by knee surgeons at the mayo clinic was the most accurate at the surgical removal (resection) of the knee-cap (patella) in a symmetric fashion during total knee replacement (arthroplasty). although all three techniques are known to be effective, the three techniques had never been compared to one another to determine if one was more effective than the others at resecting the patella.

resection of the patella to prepare it for placement of a patellar prosthesis is a procedure that is performed routinely in the vast majority of total knee arthroplasties (tka) in the united states and at the mayo clinic. this procedure is performed by a number of different techniques that have been proved to be safe and effective. despite this, patellar instability, tilt, obliquity, and maltracking are all possible complications of improperly resected patellae during tka. the goals of resection are to create a patella that is symmetrical, absent of obliquity (slanting), and thick enough to receive a patellar prosthesis. although outcomes are generally good for most described methods, to date, little had been published regarding direct comparison of these methods. patients undergoing tka with planned patellar resection were randomized to have their patella resected by one of three methods during primary tka: 1) use of a cutting guide, 2) haptic feedback, or 3) free-hand resection guided by four quadrant measurements. there were three experienced fellowship-trained arthroplasty surgeons (hip and knee) performing the procedures who were all familiar and experienced with each of the three techniques being investigated. each surgeon, within a group of 30 of their patients, performed a total 10 resections using each of the three methods listed above (30 resections per surgeon for a total of 90 resections). before and after resection measurements of knee-cap thickness were taken and used to determine patellar symmetry. the resulting symmetry of each of the three techniques was then be compared between and within each of the three techniques and surgeons. each procedure was also be timed from first measurement by the staff surgeon to the final measurement by that surgeon.

Eligibility criteria:
inclusion criteria: * patients scheduled for primary total knee arthroplasty with planned patellar resection by one of the three staff surgeons included in the study. * patient must be able and willing to provide consent for study participation exclusion criteria: * patient in need of revision total knee arthroplasty or having already undergone prior total knee arthroplasty * patient not in need of patellar resection during their primary total knee arthroplasty * unwilling or unable to provide consent for participation
morphine added to ropivacaine for ficb for postoperative analgesia

Conditions: Postoperative Pain

Summary: prospective, randomized double blinded study to investigate the effects of morphine as an adjuvant to ropivacaine on ficb


Eligibility criteria:
inclusion criteria: * all patients undergoing elective femur surgery under spinal anaesthesia * age group (18-65 years) * asa physical status i and ii exclusion criteria: * • not willing to participate in the study * other painful co-morbidities (neuropathies) * allergy or any contraindication to study medication * psychiatric disorder * coagulopathy * infection at the site of the block * use of other modes of anaesthesia or analgesia besides spinal anaesthesia.
grappler interference screw post-market collection of patient reported outcome measures

Conditions: Ankle Injuries; Syndesmotic Injuries; Ankle Inversion Sprain; Deltoid Ankle Sprain; Achilles Tendon Rupture; Flexor Hallucis Longus on the Left; Flexor Hallucis Longus on the Right; Flexor Digitorum Longus on the Left; Flexor Digitorum Longus on the Right; Ankle Sprains

Summary: ambispective, multi-surgeon, single site, consecutive case series to determine the safety, performance, and benefits of the grappler(r) interference screw.

this is an ambispective, multi-surgeon, single site, consecutive case series taking place in the united states. once a subject is identified and informed consent is obtained from that subject, retrospective data will be collected from the subject's electronic medical record (emr), and prospective data will be collected from subject-provided prom's. a minimum of 16 and maximum of 23 subjects will participate in the study.

Eligibility criteria:
inclusion criteria: * the subject underwent a foot and/or ankle procedure involving soft tissue attachment to bone using the grappler interference screw system and completed by one of the designated investigators who are experienced in the use of such implants and the required specialized surgical techniques * the subject signs a written informed consent form (icf) exclusion criteria: * none
imrt/pemetrexed/cisplatin in esophageal cancer

Conditions: Esophageal Cancer

Summary: to evaluate the effect of concomitant late course accelerated hyperfractionation radiochemotherapy with pemetrexed and cisplatin in patients with esophagus cancer


Eligibility criteria:
inclusion criteria: 1. signed informed consent; 2.acquired pathological diagnosis; 3.life expectancy≥6 months; 4.age:18-75 years, male or female; 5.general state of health: ecog 0-1 grade; 6.without any chemotherapy or radiotherapy; 7.subjects meet the following criteria for the clinical laboratory:hg≥100g/l, wbc≥3.5x109 /l, neutrophilic leukocyte≥1.5x109,plt100x109 /l。cr≤1.5 x n，tb≤2.5xn，ast and alt≤2.5xn，akp≤2.5xn. exclusion criteria: * 1.serious infection; 2.uncontrollable diabetes; 3.other serious diseases, such as myocardial infarction in 6 months; 4. participated other clinical trials in 4 weeks or at present

Keywords: imrt,pemetrexed,cisplatin , esophageal cancer
reference values of intraepidermal nerve fiber density in children and small fiber neuropathy in neurometabolic and neurodevelopmental disorders in children

Conditions: Mitochondrial Diseases; Developmental Delay Disorder; Small Fiber Neuropathy; Cerebral Palsy

Summary: background: small-fiber-neuropathy describes the degeneration of mildly or unmyelinated nerve fibers and causes neuropathic pain and autonomic dysfunction. gold standard for the diagnosis is a small skin punch biopsy from the lower leg and the histological quantification of the intraepidermal nerve fiber density (ienfd). in children, the normal ienfd has not been systematically assessed and normal reference values are needed. in parkinson´s disease, the neurodegeneration also affects the peripheral nerves and sfn is present already in the early stages. whether neurodevelopmental disorders (ndds) in childhood are likewise associated with sfn is largely unknown. the ienfd is age-dependent and declines with age. aims: in this study, we are establishing the reference values for the physiological ienfd in children from 0-18 years. moreover, we are investigating if children with ndds have a reduced ienfd and if snf is a clinically relevant cause of pain and autonomic dysfunction.


Eligibility criteria:
control patients inclusion criteria: * elective surgical intervention from lower leg * interest to participate in the study, informed consent * unremarkable neurological development exclusion criteria: * clinical signs of polyneuropathy, autonomic dysfunction * skin inflammation, scar, skin disease, other known chronic diseases that can cause small fiber pathology neurodevelopmental patients inclusion criteria: * neurodevelopmental problems (developmental delay, muscular hypotonia, seizures, ataxia,...) with age of onset before the age of 18 years * interest to participate in the study, informed consent exclusion criteria: * known polyneuropathy * skin inflammation, scar, skin disease, other known chronic diseases that can cause small fiber pathology
effectiveness of a zinc oxide adhesive securement device in the fixation of midline and peripherally inserted central catheters in hospitalized adult patients

Conditions: Vascular Access Complication; Skin and Subcutaneous Tissue Disorders; Phlebitis; Pain

Summary: study in which a zinc oxide fixation device (a product that can help protect the skin) for catheters (polyurethane tubes inserted into a vein) will be tested to reduce catheter-related complications: catheter displacement, skin complications, phlebitis and pain..

introduction: midline catheters (mlc) and peripherally inserted central catheters (picc) are commonly used vascular access devices (vad) in healthcare institutions where infusion therapies are required, and have been proven to have an optimal level of safety and efficacy for intravenous drug delivery. however, the insertion of these vads has a number of potential associated complications (immediate, early and/or late), and proper fixation may reduce them. hypothesis: using a universal zinc oxide adhesive securement device (asd) reduces the number of fixation-associated complications in mlc and picc compared to a universal asd with silicone adhesive. objective: to evaluate the efficacy of using a universal asd with zinc oxide for post insertion fixation of mlc and picc in hospitalised adult patients. methodology: randomised clinical study. two randomised groups will be created before catheter cannulation. the control group will be cured with an asd with silicone adhesiv(grip-lok® ref.3300mwa) and the intervention group will be cured with asd with zinc oxide (grip-lok® ref.2200nuza). expected results: the investigators expect to reduce the number of complications related to the attachment of piccs and mlcs in adult hospitalised patients following the protocolised placement of a asd with zinc oxide during the first cure. specifically, it is expected to reduce the number of catheter dislodgements, the number of medical adhesive-related skin injuries (marsi) and the amount of phlebitis. clinical implication: the study will help to improve decision making related to maintenance and care of vad in order to reduce the main associated complications.

Eligibility criteria:
inclusion criteria: * requiring cannulation of a midline catheter or a picc * who accepted and signed the informed consent voluntarily * with an inpatient unit admission of minimum 7 days exclusion criteria: - patients with a known allergy to zinc oxide

Keywords: catheters vascular access devices catheter-related infections nurse specialists nurses randomised controlled trial
evaluation of an intensive inpatient psychotherapy treatment for severely and early traumatized children (moses)

Conditions: Stress Disorders, Post-Traumatic

Summary: evaluation of longitudinal treatment effects applying an intensive psychotherapeutic intervention for inpatients (age of participants: 6-13 years) with a multi-method-approach to address the complex nature of severe childhood trauma. (chronic post-traumatic stress disorder)

severe adversity and trauma in early childhood have been associated with a highly increased risk for a variety of psychiatric disorders, lasting into adulthood. this increased risk is accompanied by a set of biological changes ranging from changes in cortical thickness to endocrinological changes. at a behavioral level, children with complex ptsd (developmental trauma disorder) show severe and long-lasting negative effects. such children exhibit a wide range of symptoms: affect dysregulation, attention difficulties, impairment in interpersonal relationships, aggressive and dissociative behaviour, disturbances of cognition. corresponding alterations in neural networking and brain development are well studied. although evidence-based treatment approaches for children with non-complex ptsd exist, complex-traumatized children have no well-evaluated treatments. furthermore, early intervention can prevent the chronification and exacerbation of symptoms and promote social adaptation and participation.the following topics will be addressed: (1) brain development (multimodal mri (mmri) including anatomical (t1-mprage, t2-flair, dti-diffusion tensor imaging) and functional mri measurements (resting-state functional mri, task fmri (presenting affective pictures according to the international affective picture system, iaps), eeg); (2) alterations in neuroendocrinological systems involved in stress regulation (cortisol, oxytocin, vasopressin); (3) behavioral symptoms; (4) cognitive functioning; (5) attachment representations of children and their primary caregivers;

Eligibility criteria:
inclusion criteria: * severe early traumatization with experiences of violence, neglect, abuse and chronic symptoms related to complex ptsd. exclusion criteria: * autism spectrum disorder * addiction disorder * mental disability (iq \< 85) * endangerment to themselves or others

Keywords: chronic post-traumatic stress disorder neuroses, posttraumatic ptsd
effects of cognitive-oriented intervention on major depressive disorder

Conditions: Mental Health Issue

Summary: the specific aims of the study were to explore the effects of the cognitive-oriented intervention program for promoting social support on perceived social supports, depression symptoms, and stress-coping strategies for patients with major depressive disorder in taiwan.

background: based on the 2010 world health organization declaration, depression will be ranked second among the global disease burden by 2020, second only to cardiovascular disease. it has become a disease that incurs high personal and social costs, and thus warrants considerable concern regarding its mitigation and early prevention. purpose: the specific aims of the study were to explore the effects of the cognitive-oriented intervention program for promoting social support on perceived social supports, depression symptoms, and stress-coping strategies for patients with major depressive disorder in taiwan. method: this study adopted a randomized controlled trial (rct). patients with major depressive disorder were recruited from acute psychiatric wards in a medical center in northern taiwan. the study was conducted from july 1, 2015, to december 31, 2016; 105 patients met the inclusion criteria, and 100 patients agreed to participate in the study and completed the evaluation. the participants were randomly assigned to intervention group or control group. the intervention group received a 40 mins social support intervention program once a week lasting for 6 weeks, and the control group received health education activities with the same frequency as the intervention group. all participants were assessed by questionnaires before and after the intervention. statistical analyses were performed by using descriptive statistics, independent sample t tests, and linear multiple regression analysis.

Eligibility criteria:
inclusion criteria: * diagnosed with mdd by a psychiatrist * over 20 years of age * able to speak mandarin or taiwanese and able to write. exclusion criteria: * patients who were diagnosed with other psychiatric disorders * with severe cognitive impairment or who could not make conversation acceptably were excluded.

Keywords: major depressive disorder cognitive-oriented intervention
treatment of oral premalignant lesions with 5-ala pdt

Conditions: Leukoplakia; Erythroplakia

Summary: oral leukoplakia within the mouth is a visible white patch which can develop into cancer if not treated. there is no good treatment for these lesions, apart from surgery which is associated with significant side effects and physical deformation of the treated area. the investigators hypothesized that photodynamic therapy can be used safely and effectively to induce significant regression of oral leukoplakia.

this is a combined phase i/ii non-randomized prospective study designed to determine the safety and assess the clinical efficacy of pdt in the treatment of oral leukeplekia with 5-ala and 585-nm pdl with 1.5 ms pulse time. in the first part of the study we determined the maximum tolerated dose (mtd) of the pdl radiant exposure in combination with 5-ala. in the second phase of the study, this dose is used to treat subjects at the mtd in order to determine the efficacy of the treatment by documenting the regression of the treated lesions.

Eligibility criteria:
inclusion criteria: * at least one grossly visible premalignant lesion (i.e. leukoplakia or erythroplakia) in the oral cavity or oropharynx, with a confirmed diagnosis of leukoplakia with or without dysplasia,measuring ≥ 10 mm in diameter. * informed of alternative treatment methods including watchful waiting, laser ablation, or surgical resection. * eligible for long-term follow-up for at least one year and be able to tolerate biopsies. * subject has signed an informed consent. * subject is between the ages of 18 - 80 years of age. * male or female * zubrod performance status of 0 or 1 at screening. see appendix a exclusion criteria: * known sensitivity to porphyrins or photoactive medications - see appendix b * invasive carcinoma of the lesion as demonstrated by biopsy. * subjects with inherited or acquired blood clotting defects * women who are breast feeding, have a positive (+) urine pregnancy test, or refuse to use 2 effective means of contraception during drug exposure and up to 48 hours after. * subjects with porphyria * life expectancy less than 12 months * inability or unwillingness of subject to give written informed consent