Kornimate/medical-research-clean huggingface dataset:
biomarkers in exhaled breath condensates of septic patients to predict development of multi-organ dysfunction syndrome

Conditions: Sepsis

Summary: in this proposal, the investigators wish to investigate, identify and validate potential biomarkers in collected exhaled breath condensates (ebc) from patients with sepsis.

in this proposed project, we will focus on the identification of potential biomarkers in ebc with ability to predict development of multi-organ failure. currently, no tools could be used to evaluate the effect of mitochondrial dysfunction in sepsis. all the human studies discussing mitochondrial dysfunction in sepsis use tissue biopsies as study materials. repeated tissue biopsy is invasive and not applicable. ebc could be collected non-invasively and conveniently. a study has demonstrated the use of metabolomic technologies in mitochondrial diseases. we believe that the metabolomic biomarkers of ebc could be used to demonstrate mitochondrial dysfunction in lungs and respiratory tracts of septic patients. such metabolomic biomarkers may also reflect similar on-going mitochondrial dysfunction in other organ systems, and could potentially become a novel diagnostic tool and a therapeutic target in future sepsis therapy.

Eligibility criteria:
inclusion criteria: * above 20 years old * admitted to icu with the diagnosis of sepsis and treated with mechanical ventilation via an endotracheal tube exclusion criteria: * pregnant * active malignancy * in an immunosuppressed status such as hiv disease, neutropenia, being treated with immunosuppressive agents * expected to have an unavoidable very short life expectancy after admission, i.e., \< 3 days

Keywords: sepsis
culturally adapted cognitive behavioral therapy based self help intervention for mental health of caregivers of individuals with substance use: a randomized controlled trial

Conditions: Psychological Stress; Quality of Life (QOL); Mental Health

Summary: the primary purpose of this study is to investigate whether cognitive behavioral therapy based self- help intervention can significantly reduce emotional problems as well as improve the mental well being and quality of life among the caregivers of individuals with substance use. the study aims to contribute to the existing literature by providing evidence on the efficacy of the above mentioned therapy. this can be helpful in improving clinical practices and treatment outcomes.

the current quantitative study comprises of two phases. pilot study for translation and validation of scales were done as a preliminary step. the first phase was a cross-sectional survey to screen out potential caregivers of substance users, with depression, anxiety and stress, higher than the normal level. a randomized controlled trial (rct) was done in the second phase, where caregivers of substance users who had higher level of psychological distress, were categorized into two groups; control group and intervention group through randomization. cognitive behavioral therapy based intervention (self- help manuel named, "khushi aur khatoon") was provided to the intervention group in 4-6 individual and face to face sessions. control group did not receive therapy ( on request of some of the members of control group, therapy was provided after the completion of the study). pre and post- assessment of the study variables were done for both control and intervention groups. difference between pre and post assessment was compared to investigate the effectiveness of cognitive behavioral therapy based intervention ("khushi aur khatoon") among caregivers of substance users.

Eligibility criteria:
inclusion criteria: * individuals aged 18 and above. * those who will have burden and distress above the normal levels on respective scales during baseline assessment. * capable of providing written informed consent. * residing within the catchment areas of the participating rehabilitation center. exclusion criteria: * individuals unable to provide consent due to severe mental or physical illness. * individuals not capable of reading and comprehending urdu versions of the intervention manual and scales. * unlikely to be accessible for outcome assessments due to temporary residence.

Keywords: khushi aur khatoon cbt self help intervention
prasugrel versus high dose clopidogrel in clopidogrel resistant patients post percutaneous coronary intervention (pci).

Conditions: Coronary Artery Disease (CAD); Acute Coronary Syndrome (ACS)

Summary: the use of dual antiplatelet therapy is considered standard of care in patients post percutaneous coronary intervention (pci) with stenting. however, a significant proportion of patients is considered clopidogrel resistant and this resistance is shown to be accompanied by future adverse events. additionally, clopidogrel resistance has been linked with the cyp2c19 polymorphism. the hypothesis of the study is to define in consecutive patients undergoing pci those that are clopidogrel resistant pci following routinely used loading as estimated predischarge with the verifynow point of care system of platelet reactivity. clopidogrel resistant patients will be randomized in 1:1 fashion to prasugrel 10 mg or clopidogrel 150mg daily. platelet reactivity will be assessed at day 30, when treatment crossover will be performed. at day 60 platelet reactivity will be determined as well. in addition, in all patients genetic determination of cyp polymorphisms (including the cyp2c19)known to affect clopidogrel metabolism will be performed.


Eligibility criteria:
inclusion criteria: * age ≥18 years old * patients having pci with stenting 24-48 hours prior randomization, for 1. stable angina 2.ischaemia in provocative test 3.acute coronary syndrome (unstable angina or myocardial infarction) * written informed consent * platelet reactivity units (pru) (verifynow) \>230 exclusion criteria: * a history of bleeding diathesis * chronic oral anticoagulation treatment * contraindications to antiplatelet therapy * known platelet function disorders * pci or coronary artery bypass surgery \< 3 months * unsuccessful pci (residual stenosis \> 30% or flow \< thrombolysis in myocardial infarction flow 3) * planned staged pci in the next 60 days * hemodynamic instability * cancer or hemodialysis * platelet count \<100 000/ μl, hematocrit \<30% * creatinine clearance \<25 ml/min * a life expectancy\<1 year, inability to give informed consent * high likelihood of being unavailable for the day 60 follow up

Keywords: coronary angioplasty clopidogrel resistance prasugrel
social & qol behaviors in parkinson's disease

Conditions: Parkinson Disease

Summary: adults with parkinson's disease experience an array of challenges and changes in daily living, behaviors, and functioning throughout the progression of their condition. the investigators want to learn more about the effects of parkinson's disease on individuals' social behavior and quality of life (qol) compared to people of the same age without parkinson's disease.


Eligibility criteria:
parkinson's disease group inclusion criteria: * have been diagnosed with parkinsons disease by a healthcare professional * are at least 40 years old exclusion criteria: * possess a diagnosis of autism or any other developmental disability (e.g., down syndrome) neurotypical group inclusion criteria: * are at least 40 years old exclusion criteria: * have been diagnosed with parkinson's disease by a healthcare professional * possess a diagnosis of autism or any other developmental disability (e.g., down syndrome)
demographic, clinical and laboratory characteristics of children with alpha thalassemia in northern israel

Conditions: Thalassemia Alpha; Hemolytic Anemia

Summary: the study intends to summarize the clinical and laboratory characteristics of children with hemolytic anemia diagnosed as having alpha thalassemia mutations.

fifty children and adolescents diagnosed as having alpha thalassemia will be studied, the clinical characteristics and hematology analysis will be summarized.

Eligibility criteria:
inclusion criteria: * all the patients that were studied at the pediatric hematology unit ant the ha'emek medical center exclusion criteria: * none
comprehensive hybrid cardiac rehabilitation trial on heart failure

Conditions: Heart Failure NYHA Class II; Heart Failure NYHA Class III

Summary: co-creation-hf aims to evaluate the effectiveness of a comprehensive and hybrid cardiac rehabilitation model compared to supervised exercise alone.

comprehensive, hybrid cardiac rehabilitation (cr) models have been scantly investigated in heart failure (hf) populations, particularly in low-resource settings. a 2 parallel-arm, multi-center randomized clinical superiority trial will be conducted with blinded outcome assessment. 152 hf patients (nyha class ii or iii) will be recruited consecutively, and randomly assigned. the experimental intervention will include evaluation, medical and nurse management, aerobic interval training, resistance exercise, psychosocial support, and education. these will initially be delivered in a center, transitioning to home in 4 stages. participants in the control arm will receive face-to-face continuous aerobic exercise sessions and resistance exercises. the main outcomes are cardiorespiratory fitness, functional capacity, and quality of life. these will be measured at baseline, end of intervention, and 12-month follow-up. the pragmatic, comprehensive hybrid cr model could be implemented more broadly if superiority is demonstrated.

Eligibility criteria:
inclusion criteria: * adult patients with hf of new york heart association functional class ii or iii. * meets hf diagnostic criteria of guidelines * on optimal tolerated medical therapy. * deemed by the treating physician as stable for at least 1 month. * able to attend the health center three times a week for the first month, and twice a week for the 2nd and 3rd months * owns a mobile phone * patient consents to participate in the study by signing an informed consent form. exclusion criteria: * chronic kidney disease with glomerular filtration rate \< 20 ml/min. * decompensated thyroid disease. * end-stage liver failure or child-pugh c. * cardiac device or cardiac surgery in the previous month or planned in the next 3 months. * patients with dyspnea predominantly of non-cardiac cause (e.g. copd). * atrial fibrillation with a heart rate greater than 90 beats per minute at rest. * active neoplasm with life expectancy \<2 years. * inclusion in another interventional study. * explicit contraindications to performing exercise. * comorbidities that preclude the patient from engaging in a cr program. * musculoskeletal or neurological disease that precludes the patient from performing exercise.

Keywords: cardiac rehabilitation heart failure exercise
low dose mivacurium vs. low dose succinylcholine for rigid bronchoscopy

Conditions: Intubating Conditions; Performance With Respiratory Exercise Device; Postoperative Myalgia

Summary: succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. a alternative is the application of low dose mivacurium, reversed with neostigmine. the investigators compare the intubating conditions, incidence of postoperative myalgia (pom), patient satisfaction and the postoperative performance with respiration exercise device for these two muscle relaxants.


Eligibility criteria:
inclusion criteria: * age \> 18 yr * scheduled for elective rigid bronchoscopy exclusion criteria: * known neuromuscular disease * significant hepatic or renal dysfunction * family history of malignant hyperthermia * known allergy to one of the drugs used in this protocol * pregnancy or breastfeeding

Keywords: succinylcholine mivacurium rigid bronchoscopy intubating conditions short procedure
non surgical periodontal treatment effect on il-17 and il-18 in aggressive periodontitis

Conditions: Aggressive Periodontitis

Summary: clinical parameters and il-17 and il-18 gcf levels were measured in 25 aggressive periodontitis patients compared to 25 periodontally healthy individuals. it was observed that that clinical parameters and il-17 and il-18 levels are higher before treatment but decreased after treatment which suggests role of these interleukins in pathogenesis of aggressive periodontitis .

aggressive periodontitis is a type of rapidly progressing periodontal diseases .the three classic primary characteristics of this disease are ; occurring in young healthy patients with rapid attachment loss and familial aggregation .bacteria-host interactions, insufficiencies in host defenses and possibly a genetic predisposition represent the etiologic factors . beside the young age of onset, important factors as involvement of host factors and non-plaque-related etiologic factors have also been proposed . aim of the study: objectives were to compare and correlate the clinical parameters and biochemical parameters (il-17 and il-18 levels in gcf) of aggressive periodontitis patients (at baseline and after three months of nonsurgical treatment) versus periodontally healthy subjects at baseline. subjects and methods: populations included in the study: a total of fifty individuals were enrolled and categorized as; group a that included twenty five aggressive periodontitis patients and group b which included twenty five periodontally healthy controls. clinical parameters: plaque index (pi) ,gingival index (gi), probing pocket depth (ppd) and clinical attachment level (cal) were measured at baseline for both groups and after three months of non surgical periodontal treatment completion for group a. gcf sampling: in group a ,the site with deepest probing depth was selected for gcf sampling while for group b , any site was sampled using periopaper strips . phase i periodontal treatment after baseline gcf sample collection and clinical measurement recordings, group a patients received phase i periodontal treatment. analysis of il-17 and il-18 levels in gcf: gcf samples were examined by enzyme-linked immunosorbent assay (elisa).procedures were performed according to the directions in the kits.

Eligibility criteria:
inclusion criteria: -medically free subjects. exclusion criteria: * subjects with periodontal surgeries in the last 6 months. * subjects with prior use of antibiotics in the last 6 months. * smokers. * pregnant females. * lactating females.

Keywords: gingival crevicular fluid
a study of post covid-19 mechanisms for chronic lung sequelae

Conditions: COVID-19

Summary: the purpose of this study is to understand why some people experience long term effects, such as shortness of breath and fatigue, after a severe covid-19 infection

each participant will be in the study for approximately 12 months and will be required to come to mayo clinic for 3 visits. these visits will take place approximately 2-3 months after confirmed covid-19 diagnosis (visit 1), 6 months after diagnosis (visit 2), and 12 months after diagnosis (visit 3). comprehensive clinical evaluation and symptom characterization, quantitative lung ct image analysis and pulmonary function testing, and quality of life questionnaires will be obtained at each visit. bronchoscopy with bal (collected at visits 1 and 3 only) and blood samples (collected at all visits) will dissect the dynamic immunological and molecular signatures in the respiratory tract and in the circulation longitudinally. we will also perform highly sensitive viral reservoir or remnant assays to address the potential contribution of viral factors in regulating chronic lung conditions post-acute covid-19.

Eligibility criteria:
inclusion criteria: for the sequelae group * age ≥18 years at screening, pcr confirmed covid19 illness (+pcr defines day 0 of illness), hospitalization for covid-19, absence of pre-existing history of interstitial lung disease, or significant other lung disease. * severity of illness will be categorized as moderate disease (supplemental oxygen need 1-8l at any time during hospitalization), severe disease (need for high flow oxygen delivery ≥8l at any time during hospitalization) and critical illness (need for icu admission or mechanical ventilation). control recovery group * age ≥18 years at screening * pcr confirmed covid-19 cases who had nonsymptomatic or mild acute infection that do not require hospitalization 7,48,49 * absence of pre-existing history of interstitial lung disease, or significant other lung disease, absence of any ongoing respiratory and systemic symptoms. exclusion criteria: * inability to provide informed consent, evidence of pre-existing interstitial lung disease or chronic lung disease; * active cigarette smoking, vaping or other inhalation use. * immunocompromised host status due to ongoing therapy with methotrexate, cellcept, azathioprine, rituximab, cyclophosphamide or other biologic agents; * \> 20 pack year smoking history. * history of chemotherapy or radiation therapy in the last two years; and pregnancy.

Keywords: covid-19 sars-cov-2 long covid chronic lung sequelae post-acute
specimen stability study

Conditions: Acute Kidney Injury

Summary: to collect and process urine samples from critically ill subjects for use in assessing the effects of various urine sample freezing and storage conditions on biomarker test results.


Eligibility criteria:
inclusion criteria: 1. males and females 21 years of age or older 2. subjects must be enrolled (first study-specific sample collection) within 24 hours of icu admission * subjects enrolled from ed or floor must be admitted to the icu within 24 hours of enrollment * subjects enrolled in the icu must have been admitted to the icu or transferred into the study icu from another icu no more than 24 hours prior to enrollment 3. expected to remain in the icu for at least 48 hours after enrollment 4. use of indwelling urinary catheter as standard care expected for at least 48 hours after enrollment 5. subject (or authorized representative)able and willing to provide written informed consent for study participation exclusion criteria: 1. special populations including children, pregnant women, and prisoners 2. previous renal transplantation 3. already receiving dialysis (either acute or chronic) or in imminent need of dialysis at the time of enrollment 4. known infection with human immunodeficiency virus (hiv) or active hepatitis (acute or chronic) 5. subjects with a history of chronic kidney disease (ckd) without a baseline serum creatinine value (baseline within 6 months of enrollment) 6. previously provided a urine sample and enrolled in this study
study of aripiprazole in the treatment of patients with acute symptoms of bipolar disorder

Conditions: Bipolar I Disorder

Summary: the purpose of this study is to learn if aripiprazole is effective in the treatment of patients with acute symptoms of bipolar disorder.


Eligibility criteria:
patients with acute symptoms of bipolar disorder
trauma help: healing and analgesia with propranolol

Conditions: Trauma

Summary: the purpose of this study is to determine whether propranolol can decrease pain symptoms in a common subset of patients admitted to a trauma center after injury.

the main purpose of this pilot study is to investigate propranolol's utility in the trauma population. specifically, to see if it reduces pain scores post-injury.

Eligibility criteria:
inclusion criteria: * at least one fracture * ages 18-60 yrs * pain score \>= 4 * speak and read english exclusion criteria: * gunshot, stab wound, or assault * paraplegia/quadriplegia * pregnancy * psychotic, suicidal, or homicidal * hepatic, kidney failure * clinically unstable or intubated at time of recruitment * hyperthyroidism * propranolol use within the last 6 months * significant bradycardia * cancer (except basal cell) * peripheral vascular disease * heart block \> 1 degree * breastfeeding * congestive heart failure

Keywords: pain trauma propranolol
a multiple-dose study of oral oseltamivir in participants on hemodialysis (hd) and continuous ambulatory peritoneal dialysis (capd)

Conditions: End Stage Renal Disease

Summary: this study is designed to assess the pharmacokinetics (pk) and safety of oseltamivir and its metabolite oseltamivir carboxylate in participants undergoing routine hd and capd for end-stage renal disease (esrd). participants will receive 6.5 and 6 weeks of the marketed oral oseltamivir suspension dosed according to the hd or capd schedule, respectively.


Eligibility criteria:
inclusion criteria: * adults greater than or equal to (\>/=) 18 years of age * esrd defined as no residual renal function or a creatinine clearance (crcl) less than (\<) 10 milliliters per minute (ml/min) * well established hd or capd therapy over a period of 3 months with stable crcl \< 10 ml/min * body mass index (bmi) 18 to 34 kilograms per meter-squared (kg/m\^2) * use of contraception among women of childbearing potential exclusion criteria: * clinical significant comorbid disease or terminal illness * known human immunodeficiency virus (hiv) or hepatitis b or c * history of drug or alcohol abuse within the prior year * donation or loss of \>/= 400 milliliters (ml) of blood in the 3 months prior to screening * participation in a clinical study with an investigational drug in the 3 months prior to study drug * pregnant or lactating women
telemonitoring in home mechanical ventilation

Conditions: Respiratory Insufficiency Requiring Mechanical Ventilation

Summary: multicentric, observational and longitudinal prospective evaluation of build-in-software data telemonitoring of home ventilators in patients using home mechanical ventilation in belgium.

objectives : use of a decisional algorithm (developed by la citadelle/liège) to assess telemonitoring (airview type, resmed) of data in the ventilators of patients using home mechanical ventilation (hmv), and registered in the belgian agreement for hmv at 1/ the citadelle hospital in liège and 2/hub-erasme, brussels, belgium. background: hmv initiated in the hospital is used at home. patients who benefit from hmv present significant functional limitations of cardio-respiratory, neurological and/or physical origin. such limitations compromise the ability of patients to travel to the referring hospital. as a result, good treatment follow-up is difficult to assess both from quantity and quality points of view. this is why telemonitoring systems have been developed to access ventilator build-in-software data at through dedicated online systems. in other words, data from devices operating at home can be sent to the hospital and analyzed in real time by professionnals in the hospital. this project aims to evaluate the impact of telemonitoring ventilator's data on the quality of hmv-monitoring in patients living and using hmv at home. methods: a one-year multicentric, observational, longitudinal and prospective evaluation of build-in-software data telemonitoring of home ventilators in patients using hmv in belgium. the two belgian hospitals will each follow 10 patients for one year (2024). the data from the ventilator as well as the actions to be taken in response to airview telemonitoring alerts will be carried out using a decision-making algorithm created by the citadelle hospital in liège.

Eligibility criteria:
inclusion criteria: * all patients starting hmv in 2024, followed up in 1/ liège or 2/ brussels, and using devices from the resmed company (astral 150 ou lumis 150). exclusion criteria: * individuals refusing to sign the consent form * presence of acute pathology requiring hospitalization and close monitoring of ventilation * patients using a tracheostomy

Keywords: home mechanical ventilation telemonitoring