Kornimate/medical-research-clean huggingface dataset:
impact of pre-sedation virtual reality game on post-discharge negative behaviors in the pediatric emergency department

Conditions: Behavior, Child; Anxiety

Summary: the purpose of this study is to evaluate if a virtual reality (vr) distraction game played prior to procedural sedation for long bone fracture reduction will improve post-discharge negative behavior changes following discharge from the pediatric emergency department (ed).

this randomized control trial will investigate the use of a virtual reality (vr) distraction game prior to iv ketamine procedural sedation for long bone fracture reduction. prior studies have demonstrated that children undergoing anesthesia or procedural sedation can have lingering negative behavioral changes lasting several weeks after discharge home. children who are anxious have higher rates of developing negative behavior changes. opiate pain control and pre-operative instructional workshops have demonstrated efficacy in decreasing negative behavior outcomes. there is some evidence that distraction techniques, such as vr, can alleviate pre-procedural anxiety and pain during procedures. to our knowledge, evaluating the use of a non-pharmacologic, virtual reality intervention and its effects on reducing post-discharge negative behavior changes following discharge from the emergency department has not been evaluated.

Eligibility criteria:
inclusion criteria: * children ages 6 years to 17.5 years old receiving procedural sedation with iv ketamine in the children's hospital of wisconsin emergency department for long bone fracture reduction exclusion criteria: * moderate to severe developmental delay * non-english-speaking participants or parent/guardian * taking psychotropic medications * history of severe motion sickness * currently experiencing nausea/vomiting * history of severe visual impairment * history of seizures * expected admission to the hospital post-procedure

Keywords: virtual reality procedural sedation modified yale preoperative anxiety scale post-hospitalization behavior questionnaire pediatric emergency department ketamine
comfort caregiver intervention in improving communication and reducing distress in caregivers of patients with lung cancer

Conditions: Caregiver

Summary: this pilot clinical trial studies the comfort (c-communication, o-orientation and opportunity, m-mindful presence, f-family, o-openings, r-relating, and t-team) caregiver intervention in improving communication and reducing distress in caregivers of patients with lung cancer. caregivers of patients with cancer may experience stress and anxiety due to difficulty communicating with family, friends, and healthcare providers, or feeling unable to communicate openly. a communication intervention that improves the caregiver's ability to communicate with patients and healthcare providers may help reduce caregivers' psychological distress and improve the health outcomes of patients.

primary objectives: i. to assess the feasibility of the comfort caregiver intervention (cci) for family caregivers. ii. to explore common family caregiver communication concerns in oncology and their impact. iii. estimate the effects of the cci on family caregivers' psychological distress (primary outcome) and caregiver confidence with communication (secondary outcome). outline: participants receive the printed communication tool "a communication guide for caregivers," a guide developed from the comfort communication curriculum, a national training program for palliative care communication. after a 1 week period to review the material, participants undergo communication coaching with a research nurse by phone over approximately 1 hour. after completion of the study, caregivers are followed up at 1 month to complete questionnaires and rate their satisfaction with the intervention.

Eligibility criteria:
inclusion criteria: * family caregivers will need to be the primary family caregiver as identified by the lung cancer patient (ten caregivers from each of the following cancer care continuum points will be recruited) * english-speaking * cancer care continuum points are defined as follows: * diagnosis: a lung cancer patient who has received diagnosis within the last 45 days but has not yet started treatment * treatment: a lung cancer patients who has started initial treatment (chemotherapy, radiation, surgery) for diagnosis within the last 30 days, is actively receiving treatment, and has a prognosis of more than one year * survivorship: a lung cancer patient who has completed treatment and who is clinically disease free at the time of caregiver enrollment to study * end of life: a lung cancer patient who is estimated to have 6 months or less to live * all subjects must have the ability to understand and the willingness to participate in the informed consent process exclusion criteria: * research participants who do not speak or read english * subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study
spot depression study

Conditions: Bipolar Disorder; Depressive Disorder

Summary: this study aims to identify signs of depression and bipolar disorder by measuring changes of certain molecules (biomarkers) that can be detected in dried blood spots. our goal is to use these biomarkers to develop a diagnostic test to enable early treatment, which can lead to better patient outcomes.

bipolar disorder and major depression are serious mental health conditions that have a devastating impact on patients, their families and friends, and society. currently, no laboratory test exists for these disorders. we are trying to develop a molecular test based on blood spots (small spots of blood obtained from patients' fingertips that have been dried on special paper). volunteers take part by filling out the questionnaire at www.spot-depression.org. they may then be selected to provide a dried blood spot, which can be collected at home using a kit that will be mailed to their address.

Eligibility criteria:
inclusion criteria: * residing in the united kingdom * over 18 years of age exclusion criteria: * pregnant or breastfeeding * presence of blood-borne infection
an open platform of serious games for cognitive intervention

Conditions: Mild Cognitive Impairment; Dementia; Alzheimer Disease; Aging

Summary: computer games are increasingly utilized as tools for studying cognitive skills, aging, individual differences, and development. they offer a unique advantage by presenting challenges that more closely mirror the complexities and demands of everyday tasks compared to traditional laboratory experiments, clinical tests, and standardized assessments. our team took an innovative step in this direction by developing a suite of tablet-based games, titled vibrantminds. these games, varying in type, are designed to measure diverse cognitive indicators, acting as proxies for assessments typically conducted using paper-and-pencil tests in clinical settings. vibrantminds games have been specifically crafted to be user-friendly and engaging for older adults, including those with dementia. our studies have shown that these individuals not only find the games accessible but also exhibit measurable improvement in gameplay, suggesting potential benefits for cognitive skill training. building on this foundation, we are now poised to conduct an in-depth investigation into the actual effectiveness of serious computer games (scgs) for cognitive enhancement and their application in real-world settings for older adults. this next phase of research will leverage the vibrantminds platform to carry out studies aimed at validating software-defined indicators of cognitive function and measuring the impact of game-based interventions on cognitive abilities, health-related quality of life, and other significant real-life outcomes. the anticipated results promise to expand our understanding of the potential for new technologies in cognitive assessment and intervention. moreover, by employing machine learning analysis of the data collected through vibrantminds, we aim to develop a taxonomy that correlates game complexity and player performance with conventional clinical instruments for assessing cognitive status and functioning.


Eligibility criteria:
inclusion criteria: * older adults aged 65 years and older. * cognitive impairment within a specific range as measured by the mini-mental state -examination (mmse scores between 7 and 25). * ability to interact with the serious cognitive games (scgs) platform, indicating a necessary level of awareness. * functional vision and hearing, with or without aids (glasses/hearing aids), to engage with the scgs platform. * functional upper extremity function to interact with the scgs. exclusion criteria: * presence of influenza, covid-19, or another virus that could affect performance or pose a risk to others. * inability to communicate or comprehend instructions in english * moderate to severe limitations in upper extremity control or movement, significant visual or hearing impairments, or attention deficits that could impact the ability to successfully engage with the scgs. participants or their care partners who feel these conditions would interfere with study participation are excluded.

Keywords: serious computer game computer games vibrantminds
identification of the best self-questionnaire to diagnose depression in patients with psoriasis (depsoval)

Conditions: Psoriasis; Depression

Summary: prevalence of depression shows great heterogeneity in patients with psoriasis. this could be explained by the psychometric properties of the questionnaires assessing depressive symptoms: these tests have not been developed in a context of dermatosis. the complaints and symptoms associated with psoriasis can be misidentified by questionnaires as a manifestation of depressive symptomatology and may overestimate depressive symptoms. in other diseases such as asthma and rheumatoid arthritis, tools have been validated specifically to take into account these symptoms. the purpose of this study is to validate and compare assessment tools for depression in patients with psoriasis.

the study does not modify the management of patients. patients will be contacted by phone. the protocol, the modalities and the objectives of the study will be presented during a first telephone interview. a second telephone interview will be scheduled with the patient 3 days later for the collection of his informed consent, if he agrees to participate, and the completion of the questionnaires of the study. the online questionnaires will be sent by email during this call. 1. telephone interview (5 minutes) presentation of the study. schedule a telephone appointment 3 days later. 2. telephone interview (10 minutes) collection of consent. sociodemographic questionnaire: sex, age, marital status, level of education medical questionnaire including the consumption of tobacco and alcohol, the collection of current treatments, their indications and their start dates. semi-directed telephone interview to identify the presence of depressive or dysthymic disorders (mini). 3. mailing of the self-questionnaires (20 to 30 minutes) medical questionnaire: duration of psoriasis, simplified index of psoriasis, presence of pruritus, pain eva (cutaneous and articular), fatigue. self-questionnaires bdi, phq9, ids, qids, hads assessing the intensity of depressive symptoms. 4. retest (10 minutes) some patients will be offered to re-fill the self-questionnaires assessing the intensity of depressive symptoms 15 days after completion of the survey. all participants selected for the retest will not complete all questionnaires again: the questionnaires will be distributed among the patients. the retest requires 50 patients who declare themselves stable (identified by one item) for each questionnaire.

Eligibility criteria:
inclusion criteria: * major patient, male or female, with psoriasis, less than 65 years old, followed up in the dermatology or rheumatology departments of the university hospital of clermont-ferrand. * able to mentally and linguistically answer the proposed questionnaires. * can fill out online questionnaires from his home. * affiliated with social security. exclusion criteria: * major incapable patient * refusal of participation

Keywords: psoriasis depression validation self-questionnaire
postoperative remote monitoring of vital signs in older cardiac surgery patients

Conditions: Hypoxemia; Respiratory Failure; Arrythmia

Summary: a significant number of elderly patients experience a complication after cardiac surgery. this study aims to determine if postoperative remote monitoring of vital signs can be used to identify medicatie risk factors for vital sign deterioration in older cardiac surgery patients. * single center pilot study. * 100 older patients undergoing cardiac surgery. * continuous remote monitoring of vital signs after icu discharge * main study endpoint is vital sign deterioration.

cardiac surgery in elderly patients aims to improve functional capacity and overall survival but may also precipitate major morbidity and mortality. despite major improvements in the safety of anesthesia and surgery a significant number of elderly patients experience a complication after cardiac surgery. to determine if postoperative remote monitoring of vital signs can be used to identify medication risk factors for vital sign deterioration in older cardiac surgery patients.. * single center pilot study. * 100 older patients undergoing cardiac surgery. * continuous remote monitoring of vital signs starts after icu discharge * pr, rr and spo2 will be continuously monitored in all patients. * patients and healthcare personnel are blinded for monitoring results. * main study endpoint is vital sign deterioration. the study population includes 100 patients ≥70 years undergoing elective cardiac surgery.

Eligibility criteria:
inclusion criteria: * ≥70 years undergoing elective cardiac surgery. exclusion criteria: -
energy supplements to improve exercise tolerance in metabolic myopathies

Conditions: Glycogen Storage Disease Type III

Summary: patients suffering from the metabolic myopathy glycogen storage disease type iiia (gsdiiia) have a problem releasing sugar stored in cells that is needed for energy production. this causes several systemic impairments, but only recently have the exercise-related symptoms in the muscles been examined. a previous study showed signs that intravenous infusion of glucose relieves some of these symptoms. the purpose of this study is to investigate in a randomized and placebo-controlled fashion whether oral ingestion of sugar can alleviate muscular symptoms in patients with gsdiiia.

it has recently been documented how patients with gsdiiia have a moderate to severely reduced exercise capacity, and that exercise induces muscle pain and cramps. these symptoms are caused by the inability to mobilize skeletal muscle glycogen and are most likely the consequence of a severe energy deficiency within muscles. the study changed the phenotype of gsdiiia, to include exercise-induced symptoms, which is a typical presentation in other metabolic myopathies. it also documented that exercise capacity was significantly improved while exercise-induced muscular symptoms were relieved by an intravenous glucose infusion. based on these findings, this study wishes to investigate if oral ingestion of sucrose has the same effects on work capacity on a larger number of patients, in a randomized, placebo-controlled, cross-over setup. ingestion of sucrose has the potential to be an effective, cheap and easily accessible dietary treatment of muscular symptoms in gsdiiia.

Eligibility criteria:
inclusion criteria: * genetically and/or biochemically verified gsdiiia. * 18 years or older. exclusion criteria: * clinically significant cardiac or pulmonary disease. * pregnancy or lactation. * severe mental disorders or participants that are in other ways unable to understand the purpose of the trials. * subjects where the investigator assess that it is not possible or very difficult to place an intravenous catheters. * other conditions of the joints or skeletal muscle such as arthritis or sprains. if the condition is expected to resolve before the study inclusion period is stopped, the subject may be included at a later time. * moderate to severe muscle weakness, where the participants are not expected to complete 10 minutes of cycle-ergometry exercise at 70 % of vo2peak. * verified diabetes. * participation in other clinical trials that may interfere with the results. * medications that may interfere with the results or increase the risk of bleeding. * blood-clotting or bleeding disorders. * blood donation one month or less prior to inclusion.
the use of repetitive magnetic stimulation for strength training of the quadriceps muscle

Conditions: Chronic Obstructive Pulmonary Disease

Summary: we intend to use repetitive magnetic stimulation to the quadriceps muscle to try to improve strength and improve the metabolic function of the muscle.

quadriceps strength is reduced in copd. increasing quadriceps strength is one of the goals of pulmonary rehabilitation yet some patients with severe copd are unable to exercise with sufficient intensity, due to breathlessness, to achieve a true training benefit. transcutaneous electrical stimulation of the femoral nerve has been shown to improve quadriceps muscle strength, muscle mass, and performance in patients with severe copd. magnetic stimulation may be preferred because it offers the opportunity to train the whole muscle and because it is painless. in this pilot study we are investigating whether repetitive magnetic stimulation camn increase the strength of the quadriceps muscle and whether it confers any change in structure or metabolism of the muscle itself.

Eligibility criteria:
inclusion criteria: chronic obstructive pulmonary disease exclusion criteria: aspirin therapy cardiac pacemaker -

Keywords: neuromuscular electrical stimulation
desarda's technique versus lichtenstein's technique hernia repair in management of elective non-complicated inguinal hernia

Conditions: Desarda's Technique; Lichtenstein's Technique; Hernia Repair; Inguinal Hernia

Summary: this study aims to compare desarda's technique and lichtenstein's technique of hernia repair in managing elective, non-complicated inguinal hernia.

mesh prosthesis was introduced to hernial surgery as a magic solution for any inguinal hernia, and it has significant advantages (simplicity of the procedure, mesh is cheap, and has a low recurrence rate). still, mesh induces fibrosis that can lead to stiffness and foreign body sensation, which become a source of agony for the patient. mesh infection is one of the serious complications that can lead to the removal of the mesh and long-term terms morbidity from lichtenstein hernia repairs, such as vas entrapment and chronic groin pain. desarda technique requires no extensive dissection or only suturing; no mesh is needed, and it is easy to learn. it is still ferrated and determined the optimum procedure to treat an inguinal hernia. it is a straightforward operation that avoids the risks of mesh implantation, has a low recurrence rate, and can be done by non-consultant staff.

Eligibility criteria:
inclusion criteria: * above 14 years of age. * with reducible non-complicated inguinal or inguinoscrotal hernia; unilateral or bilateral exclusion criteria: * obstructive uropathy or chronic obstructive pulmonary disease because they are contraindications to elective hernia surgery. they are associated with definite poor outcomes, such as high recurrence rates. * unfit patients for surgery * patients with strangulated hernia. * recurrent hernias. * per operative finding of separated, thin, and/or weak external oblique aponeurosis
acute effect of topical menthol on carpal tunnel syndrome

Conditions: Carpal Tunnel Syndrome

Summary: topical menthol gels are classified 'topical analgesics' and are used to relieve pain of the musculoskeletal system. however, double-blind randomized controlled trials are lacking. here the investigators examine - in a double-blind randomized controlled cross-over trial - the acute effect of topical menthol (biofreeze) and placebo (gel with a menthol scent) on pain symptoms in slaughterhouse workers with symptoms of carpal tunnel syndrome.


Eligibility criteria:
inclusion criteria: * positive phalen test * positive tinel test * nocturnal hand/wrist pain * pain intensity of at least 4 in the hand/wrist * the pain should have lasted at least 3 months exclusion criteria: * pregnancy * life-threatening disease

Keywords: carpal tunnel syndrome hand pain wrist pain arm pain topical menthol
fetal penile length and corpus cavernosum length - normal measurement via ultrasound

Conditions: Fetal Penis Length

Summary: hypothesis: measurement of fetal penis length by ultrasound may be inaccurate when measured from the scrotum to the penile tip. we will provide normal values of penile length measured from the penile tip to the abdominal wall and measuring the corpus cavernosum length.


Eligibility criteria:
inclusion criteria: * pregnant women at 14th through 34th week gestation, * routine ultrasound not preformed for anomalies at the genitourinary system, * estimated fetal weight corresponds to gestational age. exclusion criteria: * women who's fetuses are suspected to be with fetal growth retardation, * women who's fetuses are suspected to be with genitourinary anomaly.

Keywords: ultrasound penis length corpus cavernosum length of fetal penis and fetal corpus cavernosum
dynamic aspects of amino acid metabolism

Conditions: Kidney Diseases

Summary: this protocol seeks to define aspects of intestinal and hepatic uptake and metabolism of several amino acids. the major hypothesis to be tested is that the splanchic bed (intestine and liver) conserves essential amino acids and metabolites while synthesizing and metabolizing nonessential amino acids. the aims of the study include defining the relative roles of enteral and hepatic extraction/metabolism in the disposition of glutamate, alanine, methionine and other amino acids. emphasis will also be placed on studies of the transamination of alpha-ketoisocaproic acid (kic) to leucine since this reaction is of potential importance in the design of nutritional regimens for patients with renal disease.


Eligibility criteria:
inclusion criteria: * normal weight-for-height weight 50-80 kg * normal physical activity * no significant medical history * healthy by medical exam and lab blood testing exclusion criteria: * subjects who exercise vigorously * subjects who smoke

Keywords: amino acid metabolism