Kornimate/medical-research-clean huggingface dataset:
changes in food reinforcement during obesity treatment

Conditions: Obesity

Summary: the reinforcing value of food, or how much a person "wants" a food, is an important determinant of food intake. thus far, food reinforcement has only been studied in laboratory settings, and no studies have examined whether the reinforcing value of food is altered when dietary changes are made. the chronic deprivation that occurs when a low-calorie, low-fat diet is implemented for weight loss may increase the reinforcing value of all foods, but particularly for restricted high-fat foods. greater increases in the reinforcing value of high-fat foods relative to low-fat foods may be detrimental for sustaining newly adopted eating behaviors that produce weight loss, whereas greater increases in the reinforcing value of low-fat foods relative to high-fat foods may aid in maintaining healthy eating behaviors. the aim of this application is to measure food reinforcement in a clinical setting to determine if food reinforcement changes when a traditional weight loss diet is prescribed. for this ancillary study, 147 volunteers will be recruited from the 165 overweight and obese women participating in the program to reduce incontinence by diet and exercise (pride) at the miriam hospital. as part of pride, these participants will be randomized in a 2-to-1 ratio to either a 6-month weight loss intervention or usual care. assessments of food reinforcement, dietary intake, and weight will occur at 0 and 6 months. given that the intervention group changes their diet relative to the usual care group, it is hypothesized: 1) the intervention group will have greater increases in the reinforcing value of both high- and low-fat foods than the usual care group from 0 to 6 months; and 2) within the intervention group, decreases in frequency of consumption of high-fat foods will be related to increases in the reinforcing value of high-fat foods from 0 to 6 months. these results will lead to a novel line of research, examining the relationship between food reinforcement and weight loss maintenance, so that diets can be designed to promote changes in food reinforcement that aid in sustaining dietary changes and weight loss.


Eligibility criteria:
inclusion criteria: * participants from main parent study - pride exclusion criteria: * allergic to foods in investigation
effect of modulated auditory stimulation on interaural auditory perception

Conditions: Asymmetric Sensorineural Hearing Loss

Summary: this study analyzes the effect of an equalizer-modulated auditory intervention on the asymmetry of interaural auditory perception in groups with different emotional states such as well-being, anxiety, depression and mixed anxiety-depression.

the present study follows a randomized, double-blind (investigator and outcome assessor), parallel and controlled design. the auditory intervention consisted of listening to classical music modulated by an equalizer for 30 minutes, 2 sessions a day separated by at least 3 hours, for 10 days (monday to friday for 2 weeks). participants assigned to the control group are cited to the health centre, but they do not received any intervention. these subjects follow the same evaluation and data collection process. once randomized, all participants will make a first control visit in which a pure-tone audiometry was carry out and completed the various psychiatric evaluation tests to classify into different groups: goldberg anxiety and depression scale (gads), hamilton anxiety rating scale (ham-a), hamilton depression rating scale (ham-d), and sociodemographic variables (age, gender, nationality, education, working status, noise exposure, use of ear protection, and present or past use of any analgesic, anxiolytic or antidepressant for longer than a week). the study variables collected at 3 months were pure-tone audiometry (air conduction).

Eligibility criteria:
inclusion criteria: * recruited from health centre mejorada del campo (madrid, spain) exclusion criteria: * having significant hearing loss * having acute otological process * having psychotic disease * having epilepsy * having serious illness * having pregnancy * used to try alcohol or drugs

Keywords: hearing asymmetry mental disorders
molecular determinants of coronaruy artery disease

Conditions: Coronary Artery Disease; Arteriovenous Malformations; Myocardial Infarction

Summary: the purpose of this study is to discover genes that may cause coronary artery disease (cad) or arteriovenous malformation (avm).

the purpose of this study is to discover genes that may cause coronary artery disease (cad) or arteriovenous malformation (avm). many human diseases are inherited or passed from parent to child in families. these diseases occur because of damage to a gene(s), the genetic material that is also called dna. scientists can now use modern molecular techniques to locate and to find certain genes within the dna (genetic material) of a person, and to follow their inheritance in a family. to find these disease-causing genes requires studies of many affected with the disease and their family members. the purpose of this study is to locate and to find the genes for coronary artery disease (cad) which occurs when one or more of the arteries that carry oxygen-rich blood from your heart to the rest of your body develop blockages; or, arteriovenous malformation (avm) which causes abnormal vascular connections between arteries and veins, particularly near the heart. findings of the genes causing cad and avm will have far-reaching effect on the diagnosis, treatment, and prevention of coronary artery disease and arteriovenous malformation. these studies will lead to possible genetic diagnosis, early detection of persons at risk for developing cad or avm (even in the absence of symptoms), development of effective drugs, more rational and specific therapeutic interventions, treatments and ultimately, prevention of coronary heart disease. approximately 3-5 years are required to find one human disease gene.

Eligibility criteria:
inclusion criteria: * males at least 45 years old and premenopausal females at least 50 years old at the time of onset of any of the following: * ptca * mi * cabg * must have a living sibling meeting the same criteria. exclusion criteria: * substance abuse in the absence of angiographic coronary stenosis * congenital heart disease

Keywords: coronary artery disease arteriovenous malformations myocardial infarction cad mi heart attack avm genetic familial
eight-week effect of the sit-to-stand test on muscle architecture.

Conditions: Quality of Life; Quality Muscle; Arquitecture Muscle

Summary: an 8-week intervention of the sit-to-stand test (sts) of 5 and 10 repetitions will be performed to two randomly selected groups to compare its effect on the muscle architecture of the vastus lateralis muscle. h1: 10 sts significantly modifies vastus lateralis muscle architecture in adults compared to 5sts and the control group.

participants will be required to attend the laboratory for a first familiarization visit, where descriptive, biometric, and medical variables will also be evaluated. in addition, during this first familiarization session, it will be previously determined if the participants present any exclusion criteria and their muscle architecture will also be evaluated. after the familiarization session and the participants have signed the informed consent form, they will be randomly assigned to a 5 sts, 10 sts, or control group. each group (exception of the control group) will be asked to perform three times a week one of the sts modalities assigned to them for 8 weeks, to ensure that the test is completed correctly and also to maintain the planning, the evaluator will be connected virtually with the participants, where rest times will be controlled and a fatigue perception scale will be performed at the end of each session, which will allow controlling the process each session. subsequently, participants will be asked to attend the laboratory to re-evaluate their architectural parameters ( pennation angle, fascicle length, and muscle thickness) of the quadriceps muscle, one week after performing the intervention.

Eligibility criteria:
inclusion criteria: * adults, over 18 years of age. * they must have signed the informed consent form. * who can perform the sts. * in case of suffering from a chronic non-communicable disease, that it is under control. exclusion criteria: * inability to perform the sts. * hypertension (\>200/110 mmhg). * acute neuromuscular or joint injury. * who have suffered a stroke in the last 6 months. * who have suffered a myocardial infarction or fracture in the last 6 months. * terminally ill. * people who practice a sport professionally.
a longitudinal observational study of patients with nonalcoholic steatohepatitis (nash) and related conditions across the entire spectrum of nonalcoholic fatty liver disease (nafld)

Conditions: Nonalcoholic Fatty Liver; Nonalcoholic Steatohepatitis

Summary: target-nash is a longitudinal observational cohort study of patients being managed for nash and related conditions across the entire spectrum nafld in usual clinical practice. target-nash is a research registry of patients with nafl or nash within academic and community real-world practices maintained in order to assess the safety and effectiveness of current and future therapies.


Eligibility criteria:
inclusion criteria: 1. adults and children (age 2 or older) being managed or treated for nonalcoholic fatty liver disease. diagnosis is based on the clinical judgement of the care provider. exclusion criteria: 1. inability to provide informed assent/consent.
pap therapy sleep apnea and exercise

Conditions: Obstructive Sleep Apnea

Summary: positive airway pressure (pap) therapy is generally offered to patients with obstructive sleep apnea. the investigators suggest that beneficial effects of pap therapy is by preventing apneas and therefore reducing cardiac and pulmonary morbidities. the investigators sought to verify this by assessing cardiac and pulmonary function during exercise.


Eligibility criteria:
inclusion criteria: * obstructive sleep apnea diagnosed by polysomnography * cpap therapy indicated exclusion criteria: * obstructive or restrictive lung disease * cardiac failure * acute coronary syndrome * inability to cycle

Keywords: obstructive sleep apnea continuous positive airway pressure cardiopulmonary exercise test ve/vco2
study on benefits of therapy with nifurtimox in chagas disease, a parasitic illness mostly transmitted to humans by a bug, using information from patient medical records in argentina

Conditions: Chagas' Disease

Summary: the researchers in this trial want to analyze prerecorded patient data which provide information on benefits of the drug nifurtimox in patients with a sudden (acute) and long lasting (chronic) chagas´ disease an illness caused by parasites mostly transmitted to humans by a bug. they also want to learn how often organs, especially the heart, are affected by the illness in treated and untreated chronic chaga's patients. in order to find this out medical records of adult and pediatric patients in argentina will be analyzed.


Eligibility criteria:
inclusion criteria: * male and female patients aged ≥0 years at time of diagnosis with chagas' disease * diagnosis of chagas' disease confirmed by parasitological and/or serological method(s) before start of antitrypanosomal treatment or during the course of this antitrypanosomal treatment cycle for the first episode recorded. exclusion criteria: * treatment with antitrypanosomal agent(s) other than nifurtimox, including experimental investigational products for chagas' disease or antitrypanosomal combination treatment * patients with known evidence of organ manifestation of chronic chagas' disease, e.g.chagas' disease-related cardiomyopathy/heart disease, chagas' disease-related digestive disease at time of primary diagnosis.
prokinetic drugs and enteral nutrition

Conditions: Critically Ill; Enteral Nutrition

Summary: the purpose of this study is to compare the effect of two drugs that can help in the prevention of regurgitation during the administration of enteral nutrition and define which one is the most effective.

two prokinetic drugs (metoclopramide and erythromycin) will be compared during the administration of enteral nutrition in critically ill patients. we would like to know which one is the most effective in preventing regurgitation and risk of aspiration, which is a common complication of enteral nutritional support. this will be evaluated by measuring gastric residue every six hours.

Eligibility criteria:
inclusion criteria: * critically ill patients * intubated * mechanically ventilated * 18 or older age * enterally fed exclusion criteria: * prokinetic drugs before start study * allergy to study medication * interactions odf study medication with other drugs * recent gastro-intestinal surgery * history of esophagectomy or gastrectomy * suspicion of gastrointestinal perforation * myasthenia gravis * liver dysfunction * less than 7 days in study * gastro- or jejunostomy

Keywords: gastroesophageal reflux respiratory aspiration
safety of pediatric covid-19 vaccination

Conditions: Pain; Injection Site Reaction; Adverse Drug Event

Summary: this is a prospective, observational study. during the study, children and adolescents (ages ≥ 5 to \< 16) will be followed post administration of mrna covid-19 vaccines. injection site (local), systemic reaction, and unsolicited adverse event data will be assessed on vaccination day and during the 7 days following each vaccination using either identical web-based or paper diaries, depending on study participant preference. at duke university, cincinnati's children hospital, and kaiser permanente northern california, serum samples will be collected for optional assessment of antibody titers to covid-19. each participant who opts in will have baseline (within 3 days of vaccination) serologies obtained and immunogenicity assessment at 28 (+7) days after each dose. all participants will be followed for 180 days after dose 2 for serious adverse events and adverse events of special interest.


Eligibility criteria:
inclusion criteria: 1. children ≥ 5 years to \< 16 years of age 2. receiving first dose or a booster dose of a u.s authorized or approved and recommended covid-19 vaccine per standard of care 3. parent/legal authorized representative (lar) willing to provide written informed consent per local irb requirements 4. participant willing to provide assent per local irb requirements 5. intention of being available for entire study period and complete all relevant study procedures, including follow-up phone calls 6. english or spanish literate. exclusion criteria: 1. current or planned participation in any clinical trial with an investigational product during the study period.\* * per protocol, co-enrollment in observational or behavioral intervention studies are permitted at any time. an investigational product or behavioral intervention permitted at any time. an investigational product may be permitted for therapy of an illness condition that occurs during the study period (e.g., covid-19 illness) 2. any condition, which, in the opinion of the investigators, may pose a health risk to the subject or interfere with the evaluation of the study objectives. 3. anyone who is a relative of any research study personnel or is an employee supervised by study staff.

Keywords: covid-19 vaccine fever following vaccination pain following vaccination
evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ub-221 as an add-on therapy in csu patients

Conditions: Urticaria Chronic

Summary: the purpose of the study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of a single dose of ub-221 as an add-on therapy in patients with chronic spontaneous urticaria.

this is a phase i, open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of a single dose of ub-221 as an add-on therapy in patients with chronic spontaneous urticaria.

Eligibility criteria:
inclusion criteria: * subjects with age between 20 to 65 years old (inclusive). * subjects who are able and willing to provide the informed consent. * male subjects with body weight of 50 kilogram (kg) or above; female subjects body weight of 45 kilogram (kg) or above. * subjects diagnosed with chronic spontaneous urticaria (csu). exclusion criteria: * history of significant diseases (other than csu) or major clinical conditions by the investigator's judgment, such as auto-immune disease or psychiatric and behavioral conditions from which the investigator considers the subject is not suitable to participate in this study.

Keywords: ub-221 anti-ige monoclonal antibody chronic spontaneous urticaria (csu)
motion analysis in patients with hallux rigidus

Conditions: Hallux Rigidus

Summary: the aim was to investigate with a multi-segmental foot model the kinetic and kinematic in patients with a hallux rigidus, before and after different type of surgery.

none of the patients received surgery because of the study. we have only performed motion analysis in patients, who were already scheduled for one of the described type of surgery (prospective group) or who already previously received one the type of surgery (retrospective group).

Eligibility criteria:
inclusion criteria: * patients with osteoarthritis of one or both first metatarso-phalangeal joints (hallux rigidus) * patients after surgery due to osteoarthritis of one or both first metatarso-phalangeal joints (hallux rigidus) exclusion criteria: * previous operations on the foot and ankle * rheumatic diseases * relevant foot deformities other than hallux rigidus
comparing the effects of positional release technique versus myofascial release technique of gluteus medius

Conditions: Patellofemoral Pain Syndrome

Summary: patellofemoral pain syndrome is a condition of misleading diagnosis. it mostly affects individuals with ages between 18-40 years. it is believed that much work has been done on the joint itself in treating the quadriceps muscles and triggers related to it but now literature is focusing on the segmental involvement, where weakness of the hip abductors and lateral rotators play a major role. therefore, interventions used for treating this syndrome should include on focusing the hip muscles for trigger point therapy as well as strengthening them in increasing the stability of the hip and pelvis to reduce excessive valgus forces on the knee.

literature regarding gluteus medius trigger point is quite scarce especially in alleviating the pain related to patellofemoral pain syndrome. the management of patellofemoral pain syndrome includes a segmental treatment, giving special focus to the lateral rotators and abductors of the hip especially gluteus medius muscle, rather than treating the patellofemoral joint itself. it will help in improving the pain of the subjects suffering from this syndrome effectively, and within a shorter duration of time. it will also provide the practicing physiotherapist with an insight for treating such patients with better outcomes. myofascial trigger points of the gluteus medius are important contributing factors in the management of patellofemoral pain syndrome which is identified in a single study as per author's knowledge. but the treatment used to release the trigger point of gluteus medius in managing this syndrome has not yet been explored. so, this study will compare two well-known treatments in comprehending which one of the two techniques have better effects on the population to be studied. written consent will be taken from all the study participants. simple randomization technique will be used through "randomization main" software and randomization sheet will be generated. 60 participants with patellofemoral pain syndrome having gluteus medius trigger point will be randomly allocated in two equal group.

Eligibility criteria:
inclusion criteria: * anterior knee pain \>1month and \<3 month * pain in activities like ascending \& descending stairs, running or sports activity \& prolonged sitting * presence of gluteus medius trigger point in the affected limb * age group 18-40 years * both genders exclusion criteria: * dislocation of patella * damaged cartilage and ligament of knee joint * soft tissue injury related to knee * any knee or hip surgery * lumbar spine dysfunction * sacroiliac joint dysfunction * pelvic malalignment * flat foot * chondromalacia patellae * young onset osteoarthritis

Keywords: anterior knee pain gluteus medius trigger point therapy
the effect of physiotherapy on chronic low back pain

Conditions: Chronic Low-back Pain

Summary: demographic data of patients diagnosed with chronic low back pain and planned for medical treatment (n:30) and physical therapy in addition to medical treatment (n:30), as well as before and after treatment; visual analog scale (vas), oswestry disability index (odi) and short form 36 (sf-36) quality of life scoring, lumbar range of motion (lha), straight leg raising test (dbk) and hand-finger ground distance (epzm) were evaluated. hot pack, transcutaneous electrical nerve stimulation (tens) and ultrasound were given as physical therapy agents.

patients with vas, odi and sf-36 quality of life values before treatment, in addition to demographic data, who have applied to our physical medicine and rehabilitation policlinic in our hospital with chronic low back pain in the last 3 (three) months, are determined, and at least 30 above the age of 18 who received physiotherapy and who did not receive physiotherapy. patient consents obtained and vas, odi and sf-36 quality of life values questioned. pre- and post-treatment values compared, and intragroup changes compared in both groups and evaluated whether physiotherapy contributes to pain, functionality and quality of life in treatment.

Eligibility criteria:
inclusion criteria: * patients who have been prescribed medical treatment or physiotherapy for mechanical back pain * those with demographic information as well as vas, odi information in their files * patients between the ages of 20-79 who applied to our hospital with the complaint of chronic low back pain exclusion criteria: * non-mechanical back pain * patients with physiotherapy contraindications * those with inflammatory diseases * severe heart failure * stroke, spinal cord injury, plegia due to traumatic brain injury * a history of malignancy * active infection during treatment * having metal implants in the waist area * established osteoporosis * those with pacemakers

Keywords: physiotherapy low back pain quality of life functionality