Kornimate/medical-research-clean huggingface dataset:
vibration response imaging (vri) in patients that are candidates for undergoing pulmonary operation procedure

Conditions: Emphysema; Cancer

Summary: the primary objective of this study is to estimate the accuracy of the pre-operative vri quantitative results versus the gold standard pre-operative perfusion scan. the secondary objective is to assess the correlation of the predicted post-operative lung function with the observed post-operative lung function (forced expiratory volume in 1 second \[fev1\] and diffusing capacity of the lung for carbon monoxide \[dlco\]) in patients who underwent surgical resection.

pre lung operation candidates for procedures such as lung volume reduction surgery (lvrs), lung resection, bullectomy and lung transplant are frequently evaluated for differential lung function by a semi quantitative lung scintigraphy. vri may offer the same differential lung function information for the physician without the risks, time and patient discomfort of lung scintigraphy in the treating physician office. moreover, vri may provide a safe, quick and simple method to measure "split function" in lung cancer patients who are candidates for lung surgery. thus eliminating the safety and complexity issue related with the current ventilation perfusion "split function" methods. in addition the vri may aid in achieving the goal of developing strategies to reduce risk and maximize the number of patients that can benefit from surgical therapy.

Eligibility criteria:
inclusion criteria: 1. able and willing to read, understand, and provide written informed consent; 2. male or female in the age range of 18-80 years; 3. patients who were referred to perform perfusion scan for pre lung surgery evaluation such as lvrs, thoracotomy, bullectomy and lobectomy. 4. body mass index (bmi) \> 21. exclusion criteria: 1. chest wall deformation; 2. spine deformation (including scoliosis); 3. hirsutism; 4. potentially contagious skin lesion on the back; 5. skin lesion that would interfere with sensor placement; (keloids) 6. cardiac pacemaker or implantable defibrillator;
use of botox to treat scrotal pain

Conditions: Scrotal Pain

Summary: there are no previous reports on the use of onabotulinum toxin a to treat men with scrotal pain that we found published. we propose a pilot study to use botox to block the testicular nerves on a group of 15 men with chronic scrotal pain who have failed the standard medical therapy. the men must have had temporary relief from a testicular cord block using marcaine. before and 1 month, 3 months and 6 months after the onabotulinum toxin a injection, the men would be asked to fill in visual analog scales for pain, a quality of life assessment, a depression index (mdi) and chronic epididymitis symptom index (cesi). they will also be subject to sensory testing of the scrotum before, after 1 month, 3 moths and 6 months.


Eligibility criteria:
inclusion criteria: * age 18-65 * have nociceptive scrotal pain, * have no identifiable, reversible causes for the scrotal pain * have failed standard medical therapy * have responded temporarily to cord blocks exclusion criteria: * are interested in trying to conceive with their partners in the next 6 months, * have any local infection near the site of the injections, * have had an allergic reaction to botox in the past, * are unable to provide informed consent * have a history of motor neuron disease or neurogenic bladder * who have hemostatic disorder or who are taking aspirin, coumadin (warfarin), xarelto (rivaroxaban) or other blood thinners

Keywords: scrotal pain botox
uniportal versus triportal thoracoscopic lobectomy and sublobectomy for early stage lung cancer

Conditions: Lung Neoplasms

Summary: lung cancer is one of the most common cancers in the world. at present, surgical resection is still the standard treatment for early stage lung cancer. triportal thoracoscopic lung resection is a routine surgically procedure for early stage lung cancer while uniportal thoracoscopic lung resection is developing rapidly in recent years. although uniportal vats pulmonary resection has been proven to be effective in preventing postoperative morbidities, there is still no ample evidences to demonstrate that uniportal vats pulmonary resection is equal or superior to traditional triportal thoracoscopic pulmonary resection. the purpose of this multicenter randomized controlled trial study is to compare the uniportal vats with traditional triportal vats pulmonary resection in postoperative complications, long-term survival, lymph node dissection and local recurrence.

lung cancer is one of the most common cancers in the world，especially in china, where the mortality ranked first in malignant tumors whether for males or females. at present, vats (video-assisted thoracoscopic surgery) lobectomy is still the "gold standard" for the treatment of lung cancer. triportal thoracoscopic lung resection is a routine surgically procedure for early stage lung cancer while uniportal thoracoscopic lung resection is developing rapidly in recent years. retrospective study in recent years showed that the postoperative complication rate is similar between uniportal thoracoscopic surgery and triportal thoracoscopic surgery. meanwhile, the incision is more pleasing, the inflammatory response may be milder and the hospitalization time may be shorter in the uniportal thoracoscopic surgery. but until now there is no result of the randomized controlled study on the effectiveness and the prognosis between uniportal thoracoscopic surgery and triportal thoracoscopic surgery to support this conclusion. the objective of this multicenter randomized controlled trial study is to compare the postoperative complications, long-term survival, local recurrence, other perioperative variables such as conversion rate, blood loss, lymph nodes retrieved and postoperative hospital stay between the triportal vats pulmonary resection and uniportal vats pulmonary resection on early stage lung cancer.

Eligibility criteria:
inclusion criteria: * age≥18 years; * ct1- 2n0-1m0 diagnosed by chest ct, pet-ct before operation; * no severe comorbidity, can tolerate anesthesia; * ecog ps scores≤2; * the patients sign informed consents by themselves. exclusion criteria: * inability to tolerance of tracheal intubation and general anesthesia; * ecog ps scores\>2; * severe comorbidities including: angina occurs in 3 months, uncontrolled hypertension, congestive heart failure, a history of myocardial infarction in 6 months before admission, severe arrhythmia, severe liver, kidney or other metabolic diseases.

Keywords: uniportal lung cancer vats
functional mri and mra in migraine with aura

Conditions: Migraine With Aura

Summary: patients who report that exposure to bright light or strenuous physical activity will induce migraine aura will be provoked using one or both of these methods. followingly the patients will be examined by functional mri. íf the patients develop migraine headache, mr angiography will be performed as well. the primary study hypothesis is that the functional mri signal will show features similar to those of the electrophysiological phenomenon of cortical spreading depression.


Eligibility criteria:
inclusion criteria: * diagnosed with migraine with aura as defined by the international classification of headache disorders 2 * age between 18 and 80 years both inclusive * reports that bright light or strenuous physical activity may trigger migraine aura exclusion criteria: * contraindications towards exposure to photostimulation or strenuous exercise * body weight above 130 kg * pregnant or lactating females * contraindications towards mri scanning * history or clinical signs of: cardiovascular disease, psychiatric disease, substance abuse or any symptom or disease considered relevant by the examining physician.
measurement of diaphragmatic dysfunction after thoracic surgery

Conditions: Diaphragm Injury; Phrenic Nerve Paralysis; Thoracic Cancer; Postoperative Complications

Summary: this study aims to measure diaphragmatic dysfunction with ultrasonography and nerve stimulation of the phrenicus nerve, in patients undergoing thoracic surgery for lung and esophageal cancer, and correlate measures of diaphramatic function to clinical postoperative endpoints.


Eligibility criteria:
inclusion criteria: * scheduled thoracic resection surgery for lung- or esophagus cancer. for lung cancer patients, at least one lung lobe has to scheduled for resection exclusion criteria: * known diaphragmatic dysfunction * neuromuscular disease * pleural effusion \> 1cm * pneumothorax * known phrenic nerve palsy
observational study of hiv-associated neurocognitive disorder

Conditions: HIV Associated Neurocognitive Disorder; Human Immunodeficiency Virus

Summary: it is estimated that over 1 million people in the united states have hiv infection. while hiv is treatable, there are still high rates of hiv-associated neurocognitive disorder (hand). hand is defined by low scores on memory testing. to meet the criteria for hand, an hiv-infected individual has to have a low score on at least two different memory tests. it is estimated that 20-50% of people living with hiv have hand. it is therefore still a common problem. while individuals with hand typically improve on antiretroviral therapy for hiv, often this improvement is incomplete. also, there are over 20 antiretroviral medications approved for hiv in the us. it is not clear if the specific choice of antiretroviral medication makes a difference in the improvement of hand. the investigators have designed a small preliminary study in which subjects with and without hand who have never been on treatment for hiv or have been off treatment for at least 6 months are followed for the first 12 months after starting antiretroviral therapy.the investigators will enroll a maximum of 46 subjects (23 subjects in each arm). subjects will also be followed by their primary hiv medical provider. for the study, subjects will be followed for 48 weeks. there are three followup visits: 12 weeks, 24 weeks, and 48 weeks. memory testing will be performed at baseline and each followup visit. blood will also be taken at baseline and the three followup visits to measure changes in inflammation. a lumbar puncture will be performed at baseline and at 24 weeks to measure changes in inflammation and amount of hiv virus in the spinal fluid. there is also an optional lumbar puncture at the last study visit of 48 weeks


Eligibility criteria:
inclusion criteria: 1. confirmed hiv infection (haart naïve), subjects 18 to 59 years of age 2. negative serum cryptococcal antigen if cd4+ t-cell count \<100 cells/microliter, normal serum thyroid stimulating hormone level, negative serum rapid plasma reagin (rpr) (can have positive rpr ≤1:4 if treated for syphilis by cdc guidelines at least 6 months prior to enrollment, had no signs/symptoms of neurosyphilis, and rpr titer decreased at least 4-fold by 6 months after treatment). exclusion criteria: 1. ongoing heavy alcohol use (more than 2 drinks per day) or ongoing illicit drug use 2. schizophrenia or other psychotic disorder, bipolar disorder, or uncontrolled depression as reported by the subject or medical provider. 3 neoplasm of the cns or history of traumatic brain injury with loss of consciousness \> 30 minutes or cns infection in the last 6 months. 4. pregnancy or incarceration
transfusion of red blood cells, tranexamic acid and fibrinogen concentrate for severe trauma hemorrhage at pre-hospital phase of care.

Conditions: Polytrauma; Traumatic Hemorrhage

Summary: this is a single-center, not-randomized, open-label, controlled pilot clinical trial. this study compares presence of trauma induced coagulopathy (tic) and acute traumatic hemorrhage treatment at pre-hospital phase of care with red blood cells (rbc), tranexamic acid (txa) and fibrinogen concentrate (fc) with the current treatment based on the administration of crystalloids and txa.

a pilot, non-randomized, open-label study of two intervention arms and controlled with the standard treatment in which 60 patients affected with acute hemorrhage due to severe trauma will enter the study with the main objective of evaluating the feasibility and the efficacy of early treatment during the pre-hospital care phase with packed red blood cells, fibrinogen concentrate and tranexamic acid (experimental arm) compared to the standard treatment based on crystalloids administration and tranexamic acid (control arm). the secondary objectives are to evaluate the safety and clinical evolution of the patients. prior to the administration of the treatment, 2 blood samples will be extracted in both groups in order to compare the coagulation status and to be able to perform the pre-transfusion tests. on arrival at the hospital, another sample will be taken to compare changes in coagulation after the administration of the experimental or standard treatment and also between both groups. the assessment of the coagulation status will be made using the values provided by the viscoelastic test (teg6s). the experimental and standard treatment will be administered endovenously. after treatment, patients will be evaluated up to 30 days.

Eligibility criteria:
inclusion criteria: * age ≥18 years and * patients with severe trauma categorized as priority 0 or 1 according to the catsalut polytrauma code (ppt) and * evidence of bleeding or a high bleeding suspicion according to physician judgment or * predicted to need transfusion according to ticcs score ≥10 exclusion criteria: * moribund patient with devastating injuries and expected to die within 1-hour or * known objection to blood components transfusion or * known acquired or congenital coagulopathies not related to the actual trauma or * known anticoagulant treatment (vitamin k antagonist, dabigatran, rivaroxaban, apixaban) or * known pregnancy or * severe isolated traumatic brain injury or * hemorrhage not related to the actual trauma

Keywords: polytrauma red blood cells transfusion acute traumatic hemorrhage
clinical trial to monitor the efficacy of the elosan treatment by applying electrostatic

Conditions: Chronic Pain

Summary: the treatment cabin 'elosan cabin' is a closed, electrically insulated cabin for the short-term application of a high electrostatic voltage to the body of patients with chronic pain. patients assigned will have 8 sessions in the treatment cabin, with an interval of 6 days between sessions. the existing therapies and painkillers will be continued at the discretion of the doctor.

included in the study can be all persons suffering from chronic pain as it is often the case with rheumatic disease or traumata. the electric charge is created by a generator which can produce a high electrostatic field. the electrical voltage is delivered to the hands via a metal handle and is spread over the entire body surface. after the short treatment, the patient is completely discharged and earthed again. over 100 patients in eight pain centers are to be included into this trial in order to show a statistically significant reduction of pain.

Eligibility criteria:
inclusion criteria: * informed consent * adults, age ≥ 18 years, male or female patients * history of pain ≥ 3 months * suffering from chronic pain * intensity of pain rated ≥ 50 mm on vas pain exclusion criteria: * patients with an electrical or electronic implant. * women who are pregnant, breastfeeding or planning to become pregnant * patients who have already been treated with the cabin within the last 4 weeks. * patients who are currently participating in other studies or who have participated in other studies in the last 30 days * patients who have indicated their intention or who are suspected of intending to discontinue or discontinue therapy before the end of the study
supportive coaching intervention in plwha

Conditions: HIV

Summary: introduction: coaching is a process of self-exploration, thoughts, and feelings followed by actions within the coachee, through the relationship between the coachee and the coach. this process will help discover potencies in oneself as part of psychological and emotional support. objective: to investigate the effectiveness of transpersonal supportive coaching on serotonin levels and quality of life plwha. method: this research was conducted using an intervention mixed-methods design which is the integration of quantitative and qualitative approaches to study designs, data collections, and analyses. alternative hypothesis: 1. there is a difference in serotonin levels before and after transpersonal supportive coaching on plwha. 2. there is a difference in the quality of life before and after transpersonal supportive coaching on plwha

sampling technique: purposive sampling sample size : the estimation of sample size was calculated using the slovin formula: n = n / (1 + (n x e²)) n = sample n = population e = margin error (0.05) n = 100/(1+100 x 0.0025) = 80 the sample will be divided into 3 groups (each group = 26.67 or 27). detailed intervention: 1. intervention group: a group was given supportive coaching for 4 months with a 45-minute duration per coaching. it was given two times a month and also taking an antiretroviral (arv) therapy. 2. control group i: a group was given only basic support for 4 months and taking arv therapy. 3. control group ii: a group only taking arv therapy without any support was given. statistical analysis: 1. qualitative analysis using thematic and content analysis with n-vivo software 2. quantitative analysis: 1. univariate analysis using mean and standard deviation and percentage with 95% confidence interval 2. bivariate analysis using anova or kruskal wallis tests. 3. multivariate analysis using logistic regression for main effect test and process version 5.3.5. for mediation test with bootstrapping method 4. data will analysis using spss version 26

Eligibility criteria:
inclusion criteria: * newly diagnosed with hiv maximum 2 months * stadium i, ii exclusion criteria: * stadium iii and iv * opportunistic infection drop out (do) criteria: * not participating in supportive coaching for consecutive 3 times * not taking arv for 1 week

Keywords: serotonin quality of life supportive coaching plwha
phase ii iressa + irradiation followed by chemo in nsclc

Conditions: Non-Small Cell Lung Cancer

Summary: the objective of this study is to determine wether the zd1839 associated with a radiotherapy, before the beginning of chemotherapy is effective in the treatment of your disease and to evaluate the tolerance of these treatments.


Eligibility criteria:
inclusion criteria: * signed informed consent. * 18 to 75 years inclusive. * at least one measurable lesions histologically confirmed inoperable stage iii nsclc. * who performance status of 0 to 2 inclusive. * adequate pulmonary function, pulmonary dose volume histogram less than or equal to 40 %. * life expectancy of at least 6 months. * using secure contraceptives precautions. exclusion criteria: * any previous anti cancer therapy for nsclc. * known severe hypersensitivity to these products * any evidence of clinically active interstitial lung disease * other co-existing malignancies, symptomatic metastases. * abnormal blood test * weight loss of over 15% in the 3 months before the start of the study. * treatment with a non-approved or investigational drug within 30 days before day 1 of study treatment.
real world study of oxycodone sustained-release tablets for patients with moderate to severe cancer pain

Conditions: Cancer Pain; Real-world Study; Oxycodone

Summary: the goal of this real world study is to observe the efficacy and safety of oxycodone hydrochloride sustained-release tablets in the treatment of moderate to severe cancer pain participants in real clinical practice. after entering the study, participants will take oxycodone hydrochloride sustained-release tablets. the investigators need to observe and record relevant data, and finally analyze and summarize the data to understand the efficacy and safety.

this study is a prospective, single arm, multicenter real world study, the investigators didn't set up a control group. after the participant is enrolled, the participant will enter a 14 day treatment cycle, where the medication will be proportionally converted into oxycodone hydrochloride sustained-release tablets. the daily medication dose will be adjusted based on the number of pain outbreaks and pain scores (according to the drug increment principle of nccn), and various information (daily oxycodone dose, average pain score, minimal pain score, most severe pain score, number of breakout pain, name of rescue drugs, number of rescue, heart rate, blood pressure, respiratory rate, spo2, combination of drugs, pain control satisfaction, etc) about the participant's medication will be recorded. the participant will not be limited to whether to combine medication. observe the efficacy and safety of oxycodone hydrochloride sustained-release tablets.

Eligibility criteria:
inclusion criteria: 1. voluntarily sign an informed consent form; 2. age ≥ 18 years old; 3. patients with moderate to severe (nrs ≥ 4 points) cancer pain; 4. patients with oral equivalent oxycodone hydrochloride sustained-release tablets ≥ 80mg/d. exclusion criteria: 1. patients with severe mental illness who cannot cooperate with follow-up

Keywords: oxycodone hydrochloride sustained-release tablets
an open-label study to assess the rate of failure of an enbrel® (etanercept) sureclick™ auto-injector in subjects with rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: an open-label, single arm study to estimate the rate of failure of the enbrel® sureclick™ auto-injector in ra subjects.


Eligibility criteria:
inclusion criteria: - diagnosis of rheumatoid arthritis * ra subjects * 18 years or older * currently taking etanercept in pre-filled syringes for at least 4 weeks * subjects must give written informed consent * subjects must be able to read and write in english exclusion criteria: - subject is not using adequate contraception * subject is pregnant or breast feeding * significant concurrent medical diseases

Keywords: rheumatoid arthritis device auto-injector sureclick enbrel etanercept
abdominal trunk function after surgical repair of abdominal rectus muscle diastasis

Conditions: Rectus Abdominus; Diastasis, Complicating Delivery

Summary: there is insufficient evidence regarding the benefit from surgical reconstruction of post-partum abdominal rectus muscle diastasis. the purpose of this study is to evaluate the abdominal trunk function preoperatively and postoperatively in a group of women undergoing surgery for abdominal rectus muscle diastasis.

there is little evidence regarding the various treatment options of abdominal rectus muscle diastasis in post-partum women. the lack of evidence may, to a great extent, be explained by the lack of uniform criteria for assessing the trunk function and how the trunk function affects the ability to perform daily activities. to be able to evaluate the condition with symptomatic ard a more comprehensive, multimodal instrument is therefore needed. in collaboration with the surgical clinic and the physiotherapy clinic at södersjukhuset a multimodal examination test was developed with the purpose to be able to evaluate the full picture of the condition. the purpose of this study was to evaluate the effect of surgical reconstruction of post-partum abdominal rectus muscle diastasis in women with insufficient improvement after adequate physical training using a novel multimodal evaluation tool.

Eligibility criteria:
inclusion criteria: * non-smoking women * bmi \<35 * inter-recti distance \>3cm * lack of response to standardized core stabilizing training * \>1 year since last partus * no intention of further pregnancies exclusion criteria: * inability to quit smoking * bmi \>35 * inter-recti distance \<3cm * \<1 year since last partus * further pregnancies not excluded