Kornimate/medical-research-clean huggingface dataset:
safety and efficacy of argatroban applicated in anticoagulation of v-v ecmo

Conditions: Respiratory Failure

Summary: unfractionated heparin is most common in the anticoagulation management of v-v ecmo. however, many side effects of unfractionated heparin, such as hit, antithrombin deficiency, etc seriously affects the prognosis of patients. argatroban is kind of direct thrombin inhibitors, which could be used used as an alternative anticoagulant of unfractionated heparin when hit or antithrombin deficiency, etc. at present, there is no power enough evidence for the application of argatroban in v-v ecmo. this study aims to evaluat the safety and effectiveness of argatroban in the anticoagulation management of v-v ecmo compared with unfractionated heparin.


Eligibility criteria:
inclusion criteria: * age older than 18 years old; received v-v ecmo because of sevever respiratory failure exclusion criteria: * anticoagulant contraindications; confirmed or suspected, or previously diagnosed with heparin induced thrombocytopenia; cerebral infarction or suspected patients; patients with severe liver dysfunction; allergic to heparin or argatroban; hemophilia; unwilling or unable to complete the study.
does longitudinal nursing follow-up improve smoking cessation in patients referred for copd screening

Conditions: COPD; Nurse's Role

Summary: a monocentric study to evaluate the efficacy of a longitudinal nursing follow up in smoking cessation in patients screened for chronic obstructive pulmonary disease (copd).

the challenges to limit the occurrence of copd are early detection, the fight against smoking and smoking and addictions (e.g. cannabis), as well as the fight against environmental exposures. we proposed to evaluate if a longitudinal nursing follow-up at 3 months, 6 months and one year, in patients coming to screening for copd. cessation of respiratory toxics is the most effective intervention in stopping the progression of copd.

Eligibility criteria:
inclusion criteria: * smoking patients screened for copd between 35 years old 65 years old * read, write and understand the french language * patient affiliated to a social security system * written and signed informed consent exclusion criteria: * patients with a diagnosis of respiratory diseases * patients receiving inhaled respiratory therapy * persons unable to perform spirometry * pregnant women * refusal to participate in research * patient under guardianship, deprived of liberty, safeguard of justice
tens for back pain emergency department

Conditions: Back Pain

Summary: in this study we will see if application of tens for a period of 30 minutes in addition to ibuprofen reduces the pain of emergency department patients with back pain compared with ibuprofen and a sham tens unit.

adult patients presenting to the emergency department with moderate to severe back pain of relatively short duration without neurological deficits will be eligible for inclusion in the study. after signing informed consent the patients will rate their pain severity and receive a 400 mg dose of ibuprofen and then randomly be assigned to either tens or sham tens for 30 minutes. at the end of the study period patients will again be asked to rate their pain severity and indicate whether their pain got better or worse. we will also ask them to try and guess which treatment they received and whether they require any medications for their pain.

Eligibility criteria:
inclusion criteria: * adults age 18 years or greater * able to consent * back pain of less than 2 weeks duration * pain severity of at least 5/10 on a verbal numeric scale from 0 (none) to 10 (worst) exclusion criteria: * pregnant patients * minors * prisoners * neurological deficits

Keywords: tens, back pain, ibuprofen
open label study of ds-5573a

Conditions: Advanced Solid Malignant Tumors

Summary: this is an open-label, sequential dose escalation and expansion study to evaluate the safety, and pharmacokinetics of ds-5573a in japanese patients with advanced solid malignant tumors.


Eligibility criteria:
inclusion criteria: * advanced solid tumor that is refractory to standard treatment, or for which no standard treatment is available. * eastern cooperative oncology group performance status(ps) of 0 or 1 exclusion criteria: * have any of the following concomitant disease or had the history of having following disease within 6 months before enrollment: cardiac failure (nyha ≥ classiii), myocardial infarction, cerebral infarction, unstable angina, arrhythmia requiring treatment, coronary-artery/peripheral artery bypass surgery, cerebrovascular disease, pulmonary thromboembolism, uncontrolled deep-vein thrombosis or clinically severe thromboembolic event, or autoimmune disorders requiring treatment. * severe or uncontrolled concomitant disease. * clinically active brain metastases defined as symptomatic or requiring treatment.

Keywords: advanced solid malignant tumor phase 1 oncology
postural sway at menstrual cyclus

Conditions: Women's Health: Endometriosis

Summary: the study was planned with the aim of comparison of postural sway responses at menstrual cycles in women with and without the dysmenorrheal syndrome. women will stand on a postural sway evaluation system on the first day of the menstrual cycles and a well-being day which they will select. every participant will be evaluated same tool. they will be assessed for three times at every session: 1st evaluation will be performed at the normal standing position. 2nd evaluation will be performed at the normal standing position while individuals saying the numbers from 200 to 1. 3rd evaluation will be performed at the normal standing position while individuals holding the mini blocks on their hands.

the study was planned with the aim of comparison of postural sway responses at menstrual cycles in women with and without the dysmenorrheal syndrome. women will stand on a postural sway evaluation system on the first day of the menstrual cycles and a well-being day which they will select. every participant will be evaluated with the same tool. they will be assessed for three times at every session: 1st evaluation will be performed at the normal standing position. 2nd evaluation will be performed at the normal standing position while individuals saying the numbers from 200 to 1. 3rd evaluation will be performed at the normal standing position while individuals holding the mini blocks on their hands. results will be compared for menstrual cycles and well-being day in women with and without pain at menstrual cycles.

Eligibility criteria:
inclusion criteria: * have dysmenorrheal syndrome * have menstrual cycle without pain exclusion criteria: * have another health problem (systemic, neurologic, orthopedic or psychiatric)

Keywords: menstrual postural sway dual task
effects of beetroot juice intake and physical exercise in postmenopausal hypertensive women

Conditions: Hypertensiona; Menopause

Summary: the goal of this clinical trial is to verify the hemodynamic and biomarker responses of aerobic physical exercise and beetroot juice intake in postmenopausal women with hypertension. the main questions it seeks to answer are: is beetroot juice and aerobic exercise related to better hemodynamic responses in hypertensive postmenopausal women? is beetroot juice and aerobic exercise related to better oxidative stress profile responses in hypertensive postmenopausal women? the researchers will conduct a parallel clinical study with 10 days of intervention, in which 48 women will be randomized into 3 groups: 1) aerobic exercise; 2) one shot of beetroot juice intake per day (400mg of no3-); 3) control (no intervention).

the entire intervention will take place at the physical education campus of university, in the cardiorespiratory and metabolic physiology laboratory (laficam). the recruitment and approach of the volunteers will occur through media dissemination, such as radio announcements, television programs, and social media through digital media. after the dissemination, volunteers will make contact via phone, email, or social media, and a preliminary registration will take place. after this registration, the researchers will verify which volunteers meet the inclusion criteria, and only then will the recruitment take place. the volunteers will be invited to come to laficam to be informed about the intervention program and then sign the informed consent form. before starting the intervention program, all volunteers must present a medical certificate clearing them to participate in a physical exercise training program; once the certificate is submitted, initial tests and general evaluations will be conducted. the initial evaluations will consist of a questionnaire, anthropometric and body composition assessment, and evaluation of the physical activity level. after the questionnaires are administered, a familiarization with the sensory perceptions of beetroot juice will be conducted. this familiarization is important to verify if the volunteers are fit to carry out the intervention. the volunteers will be randomized into three groups: group 1: the volunteers will perform a moderate physical exercise session lasting 40 minutes for 10 consecutive days; group 2: this group will ingest 70 ml of beetroot juice with 400 mg of nitrate every morning for 10 days. group 3: this group will ingest 70 ml of beetroot juice without nitrate for 10 days.

Eligibility criteria:
inclusion criteria: * amenorrhea for at least 12 months * controlled hypertension * suitable for physical exercise * present a certificate proving fitness to practice physical exercise exclusion criteria: * decompensated hypertension in stages 2 and 3 * having a history of stroke or acute myocardial infarction * smoker * having physical problems or cardiovascular complications that prevent physical exercise * having a diagnosis of diabetes mellitus * using hormone therapy.

Keywords: beetroot juice hypertension postmenopausal exercise blood pressure
prognosis in adult patients with congenital heart disease

Conditions: Adult Congenital Heart Disease

Summary: this is a mono-center observational ambispective study in which adult patients with congenital heart disease evaluated at our institution will be enrolled. the primary endopoint is to assess the clinical and echocardiographic predictors of adverse events during follow-up (death, arrhythmias, cardiac hospitalization). the secondary endpoints are: 1) evaluation of the incidence of the singular components of the primary endpoint; 2) evaluation of the prognostic impact of acquired lesions, including valve disease not present at birth; 3) need for surgical/percutaneous interventions during follow up. participants will be evaluated in the context of scheduled follow-up visits in our outpatient achd clinic. no interventions/drug administration will be performed other than those required by standard clinical practice.


Eligibility criteria:
inclusion criteria: * patients evaluated in our achd outpatient clinic between january 2014 and december 2026 * age ≥ 18 years exclusion criteria: * patients without congenital heart disease confirmed during the first evaluation * impossibility to retrieve information about the first clinical evaluation in our clinic from our electonic datasets * follow up shorter than one-year * refused consent to participate to the study.

Keywords: adult congenital heart disease achd prognosis long-term follow-up
pragmatic study comparing the clinical evlauation methods ( c) and / or ultrasound method ( b or d) in rheumatoid arthritis to adapt treatment

Conditions: Rheumatoid Arthritis

Summary: this study compares different methods of clinical evaluation (c) and/or ultrasound (b or d) concerning the rheumatoid arthritis in order to monitore the treatment. this study will provide the exact number of patients in remission according the 3 methods. it could allow to assess the concordance between the 3 evaluated methods. this study will permit to define the best method which limit the evolution of structural damages ( principal criteria).

the aim of this study is to evaluate the xrays evolution at 1 year ( at least one new erosion versus no erosion with the sharp modified by van der heijde) of patients affected by rheumatoid arthritis (acr/eular 2010). the first approach is the assessment of remission defined by modified sdai in order to evaluate in all cases the same number of joints \[simplified disease activity index algebric sum of 5 parametres : number of painful joints (28 joints) , number of synovitis (38 joints), global evaluation of patient and and practitioner with vas, and pcr ≤ 3.3mg/l\] (mode c). the second one is a combined approach: clinical-ultrasound (same criteria but with mtps and shoulders in b mode so a 26 joints evaluation with clinical examination and 12 joints evaluation in b mode) (mode b). the last one is an ultrasound approach (remission defined as the absence of power doppler on 38 joints (28 of sdai plus 10 mtps joints) (mode d) in a pragmatical context (study assessed by private rheumatologists and hospital rheumatologists). this trial is a national randomized multicentre trial that compares three modes of follow to adjust the therapeutic adaptation in rheumatoid artritis.

Eligibility criteria:
* inclusion criteria: * both gender patients aged 18 -to 80 years old * patients will be eligible if they fulfill acr/eular 2010 rheumatoid arthritis * all the treatment recommended for rheumatoïd arthritis (anti-inflammatory drugs, steroids, hydroxychloroquine, salazopyrine, methotrexate, arava or biologics treatment: enbrel, humira, remicade, cimzia, tocilizumab, rituximab, abatacept, simponi) would be in stable posology since at least 12 weeks before inclusion * patients would be able to understand and be agree with the protocole * patients would be able to consent * exclusion criteria: * patient unable to cooperate patient and who refuse to sign consent form * patient unable to understand the study,under administrative supervision or legal guardianship * signs and symptoms of uncontroled or severe progressive pathology at the level of renal, hepatic, hematological, endocrine, lung, cardiac, neurological or cerebral * scheduled surgery procedure during the study on the estimated joint. * patient non-affiliated to social security * pregnant and nursing mothers

Keywords: rheumatoid arthritis / ultrasonography / synovitis
measuring cholesterol in the fasting and postmeal state in patients with type 2 diabetes

Conditions: Type 2 Diabetes

Summary: many patients with type 2 diabetes have difficulty attaining cholesterol goals, partly due to the recommendations for fasting measurements that may not be practical in the typical clinical setting. focus toward therapy is shifting toward non-fasting assessments but little is known about the usefulness of this approach in diabetes, where postmeal cholesterol levels are more abnormal. this is an observational study examining fasting and postmeal lipids (cholesterol) in patients with type 2 diabetes using standard means and nmr.

current treatment guidelines for dyslipidemia focus on fasting lipid panels, specifically ldl cholesterol (ldl) but compliance has been shown to be poor. therefore, focus has shifted to non-fasting measurements. however, there has been limited data in patients with type 2 diabetes and further study is needed to illuminate the lipid changes that occur in the non-fasting state. this observational study examines fasting and postprandial lipids in patients with type 2 diabetes using standard chemical analysis and nmr. for comparison, lipid panels will be obtained at baseline and 3 hours following a standard meal in 30 patients with type 2 diabetes. these measurements will then be analyzed based on current atp iii guidelines. we will investigate the degree to which the postprandial assessments agree with the fasting assessments and the agreement between ldl and the two alternative measures --- non-hdl and nmr-ldl.

Eligibility criteria:
inclusion criteria: * age 20-75 * male or female * type 2 diabetes * hemoglobin a1c less than 9 at last measurement (within 3 months) exclusion criteria: * pregnancy * non-english speaking. * inability to fast for 12 hours * hypoglycemia requiring assistance in the previous 6 months * unwilling to consume the standardized meal

Keywords: type 2 diabetes hyperlipidemia dyslipidemia fasting lipids postprandial lipids non-hdl cholesterol nmr lipoanalysis atp iii guidelines
long term follow-up of vertebral compression fracture in-patients treated: a retrospective chart review and survey

Conditions: Vertebral Compression Fracture; Korean Traditional Medicine; Integrative Korean Medicine; Vertebral Compression

Summary: the purpose of this study is to reveal the effectiveness and safety of integrative korean medicine for vertebral compression fracture in-patients by observing inpatients treated with integrative korean medicine. this study is a retrospective observational study. the subjects for study are patients diagnosed with vertebral compression fracture and who have been admitted to four jaseng hospital of korean medicine (gangnam, bucheon, daejeon, and haeundae) for 2016.04.01-2022.06.30. medical records of selected patients will be analyzed, and telephone surveys will be conducted for each patient. the survey questions are numeric ratinc scale (nrs), oswestry disability index(odi), quality of life, and patient global impression of change (pgic), etc.


Eligibility criteria:
inclusion criteria: 1. patients diagnosed with acute compression fracture' of thoracic or lumbar vertebrae from emr x-ray or mri, ct imaging (the temporal criterion for dividing acute and chronic compression fractures was based on 3 months after symptoms began in the case of compression fractures caused by osteoporosis, and acute and chronic were also divided based on 3 months after trauma.) 2. patient hospitalized for more than a week 3. pateints above 19 years old and below 80 years old 4. patients who have agreed to participate the study exclusion criteria: 1. where the vertebral fracture is not a vertebral body, but a transverse protrusion, a polar protrusion, etc. 2. other chronic conditions that may interfere with the interpretation of treatment effects or outcomes: cardiovascular disease, kidney disease, diabetic neuropathy, dementia, epilepsy, etc. 3. if the cause of pain is due to soft tissue disease, not the spine: tumor, fibromyalgia, rheumatoid arthritis, gout, etc. 4. a person with a congenital spinal disorder 5. for patients within 3 months of spinal surgery 6. a person who is unable to communicate normally due to dementia or mild cognitive impairment; 7. other cases where the researcher is not suitable for participation in the study. 8. those who do not agree to participate in the study.

Keywords: compression fracture integrated complementary and alternative medicine:
safety and efficacy study of iontophoresis and dexamethasone phosphate to treat dry eye

Conditions: Dry Eye Syndrome

Summary: the purpose of this study is to assess the safety and efficacy of iontophoretic delivery of dexamethasone phosphate ophthalmic solution using the eyegate® ii drug delivery system in patients with dry eye.

the objective of this study is to assess the safety and efficacy of ocular iontophoresis with dexamethasone phosphate 40 mg/ml 7.5 ma-min at 2.5 ma and ocular iontophoresis with dexamethasone phosphate 40 mg/ml 10.5 ma-min at 3.5 ma compared to placebo for the treatment of the signs and symptoms of dry eye.

Eligibility criteria:
inclusion criteria: * have a reported history of dry eye in each eye * be at least 12 years of age * demonstrate a response when exposed to the controlled adverse environment model exclusion criteria: * have contraindications to the use of the test articles * have known allergy or sensitivity to the study medication or their components (including corticosteroids) * have any ocular infections, active ocular inflammation or preauricular lymphadenopathy * be current contact lens wearers or wear contacts during the study

Keywords: dry eye iontophoresis ophthalmic delivery
multiple attacks study to compare the efficacy and safety of mk-0974 with placebo for acute migraine (mk-0974-031)

Conditions: Migraines

Summary: the purpose of the study is to assess the safety and efficacy of telcagepant (mk-0974) in acute treatment of multiple migraine attacks with or without aura. primary hypotheses of this study are that telcagepant is superior to placebo, as measured by the proportion of participants who have pain freedom, pain relief, pain freedom consistency, pain relief consistency, and absence of photophobia, phonophobia, and nausea at 2 hours post-dose.


Eligibility criteria:
inclusion criteria: * history of migraines within the past year * 1 to 8 moderate or severe migraine attacks per month in the past 2 months that lasted between 4 to 72 hours if untreated * use acceptable contraception throughout the study * able to complete the study questionnaire(s) and paper diary * limit consumption of grapefruit juice to no more than one 8 ounce glass a day exclusion criteria: * pregnant or breast-feeding or is expecting to become pregnant during the study * difficulty distinguishing his/her migraine attacks from tension or interval headaches * a history of mostly mild migraine attacks or migraines that usually resolve spontaneously in less than 2 hours * more than 15 headache-days per month or has taken medication for acute headache on more than 10 days a month in the past 3 months * greater than 50 years old at the age of migraine onset * previously taken telcagepant

Keywords: multiple attacks of moderate to severe migraine headaches
efficacy of etoricoxib 60 mg in modifying pain hypersensitivity in people with knee osteoarthritis

Conditions: Osteoarthritis; Pain

Summary: this study aims to better understand the way in which painful osteoarthritis affects different people and whether an anti-inflammatory medication such as arcoxia (etoricoxib) can help to modify this pain. the study will use questionnaires and tests of pain sensitivity to identify arthritis sufferers with more widespread, nerve-type pain and then to investigate whether a daily dose of arcoxia is more effective than a placebo pill in reducing these symptoms and improving functional movements. the study will also be comparing the same test results of a small group of subjects without knee pain.


Eligibility criteria:
inclusion criteria: * unilateral diagnosis of knee oa \> 6 months * knee pain \> 4/10 on womac pain subscale * if pain in contralateral knee, no greater than "mild" * no other significant joint involvement * ara functional class i, ii or iii * no arthroscopy or injections into index knee in last 6 months exclusion criteria: * history of systemic inflammatory or chronic pain disorders (especially fibromyalgia) * neurological deficit * recent (\< 6 months) lower limb surgery * allergic reaction to nsaids or aspirin * skin allergies, dermatitis * contraindications to cox-2 inhibitors: * congestive heart failure (nyha ii-iv) * unstable hypertension * ischaemic heart disease * peripheral artery disease * cerebrovascular disease including cabg or angioplasty within 1 year * severe hepatic dysfunction * active gi bleeding or peptic ulceration * reduced creatinine clearance \< 30 ml/min * current use of high dose (\> 325 mg daily) aspirin

Keywords: mechanical hyperalgesia cold hyperalgesia chronic pain