Kornimate/medical-research-clean huggingface dataset:
internet-based cognitive behavioral therapy for children with dental anxiety

Conditions: Dental Anxiety

Summary: the purpose of this study is to determine whether internet-based cognitive behavioral therapy (icbt) is effective in the treatment of children and adolescents with dental anxiety. the investigators hypothesis is that children and adolescents who have been offered icbt show significant better performance on outcome measures compared with patients in control group.


Eligibility criteria:
inclusion criteria: * the participant is between 8-15 years of age * the patient and parents agree to participate in the research project * a diagnosis of specific phobia (dental anxiety or intraoral needle phobia) can be established by a psychologist according to the diagnostic and statistical manual of mental disorders, 4th. edition. the internet parent version of development and well-being assessment (dawba) and kiddie sads (phobic disorders supplement) are used. * the patient and parents have sufficient language skills in swedish to manage the treatment and questionnaires * have regularly access to computer and the internet * have the time, the possibility and motivation to work and practice with icbt 3 hours each week in 12 weeks * parents agree to at least book three visits at the dentist during the 12 weeks treatment * parents agree to exposure for intraoral injection at the dentist even if the child does not need dental treatment but suffers from injection phobia exclusion criteria: * full points on both child and parent versions of the picture guided behavioral approach test. a maximum score of 17 means that both the child and the parent assess that the child can manage the most challenging situations in dentistry * a score of 31 or less on both children and parent version of cfss-ds and do not fulfill criteria for intra-oral injection phobia * already have or according to dawba and/or telephone interview by psychologist likely to fulfill criteria for a neurodevelopmental disorder diagnosis * other psychiatric disorders such as severe depression, eating disorder or self harm behavior that need treatment prior to dentistry related specific phobia * the participant is undergoing or has planned psychiatric/ psychological examination * the participant has current/planed psychological treatments * stressful life experiences during the past 12 months, such as divorce in the family, somatic illness that parent or the psychologist see as an obstacle in the treatment * have received cognitive behavioral treatment for dental anxiety or needle phobia during the past three years

Keywords: dental fear dental phobia internet based cognitive behavioral therapy specific phobia children and adolescents anxiety self efficacy
the effects of dietary phosphate intake on calciotropic hormones and fgf23.

Conditions: Healthy; Kidney Failure, Chronic

Summary: the purpose of this study is to determine the effects of different amounts of phosphorus in the diet on hormones that control phosphorus and bone health both in people who are healthy and in ones who have moderate kidney disease.

chronic kidney disease affects 11% of the us population; over half of those affected have skeletal manifestations of their renal disease. renal osteodystrophy is a complex disease, in which multiple mineral systems and related hormones play a role, including phosphate homeostasis. phosphate regulation primarily depends on renal handling of phosphate, which is partly controlled by parathyroid hormone and vitamin d. however, other mediators in this system clearly exist. recently, evidence has been accruing that one such factor may be fgf23, a protein produced by osteogenic cells. states of excess fgf23 are associated with marked phosphate wasting, hypophosphatemia, osteomalacia, and inappropriately low calcitriol. fgf23 levels are measurable in healthy humans and markedly elevated in patients who require hemodialysis, although its physiologic role in either state is unknown. some retrospective evidence suggests that fgf23 is affected by phosphate intake. we are performing a study to gather data describing the response of fgf23 to changes in dietary phosphorus intake in healthy men and women and in men and women with moderate renal insufficiency. the specific aims of this pilot study are: 1) to examine the physiologic effects of alterations in dietary phosphorus on fgf23 in healthy subjects; 2) to examine the physiologic response of fgf23 to dietary phosphorus alterations in patients with moderate renal failure; and 3) to assess whether serum levels of 1,25-dihydroxyvitamin d vary inversely with those of fgf23 when dietary phosphate is changed. the proposed research plan is a dietary intervention trial in which we will study the response of serum fgf23 levels to diets with varying phosphorus contents in healthy adults and adults with moderate renal insufficiency.

Eligibility criteria:
inclusion criteria: healthy subjects: * men 21-65 years of age; * premenopausal women over 21 years of age taking oral contraceptives; * postmenopausal women less than 65 years of age; chronic kidney disease subjects: * men 21-65 years of age; * premenopausal women over 21 years of age taking oral contraceptives; * postmenopausal women less than 65 years of age; * creatinine clearance between 30 and 59 ml/min/1.73 m2 as calculated using the equation derived from the modification of diet in renal disease (mdrd) study. exclusion criteria: * medications affecting bone metabolism; * abnormal liver or gi function; * extreme electrolyte abnormalities; * bmi \>30 kg/m2.
impact of tracheotomy on procalcitonin

Conditions: Tracheotomy

Summary: procalcitonin (pct) is a reliable biomarker of infection and sepsis. the investigators aimed to determine whether tracheotomy influences pct concentrations in patients without sepsis, and to assess whether operative duration and procedure affect the peak pct level.

procalcitonin (pct), a soluble protein composed of 116 amino acids with a sequence identical to that of the calcitonin prohormone, has been considered as a reliable biomarker for evaluating of bacterial infection and sepsis. in healthy individuals, serum pct concentrations are undetectable, however, in case of severe bacterial infections and sepsis, it increase rapidly released mainly in peripheral blood mononuclear cells and modulated by bacterial lipopolysaccharides (lps) and sepsis-associated cytokines. an increase number of studies have demonstrated that pct-guided strategy is a helpful approach to guide antibiotic administrations and clinical interventions in the intensive care unit (icu). however, pct is induced in the plasmas of patients not only at the presence of bacterial infection, but also in stress conditions such as severe trauma and surgery. in these conditions, the increases are moderate. the mechanism of the nonspecific increase is complicated. other conditions with elevated pct concentrations include medullary thyroid carcinoma , cancer, anaphylactic shock, heat shock , cardiac arrest, kawasaki disease, and so on. these findings suggest that elevated pct levels lack the speciality to detect sepsis in critically ill patients. tracheotomy is one of most performed surgical procedures to assure airway by making a hole in front of the trachea in icu. there are studies in literature that show the surgical procedures to the neck area cause a surgical stress, an increase in thyroid hormones. the procedure may due to miscellaneous clinical signs by altering in hormone levels, even creating a thyroid storm. as far as we are aware, there is no study on the impact of tracheotomy on pct concentration. the aim of the study was to evaluated whether tracheotomy affects pct concentrations in patients without sepsis. moreover, the investigators assessed whether operative duration and procedure were correlation with the peak pct level.

Eligibility criteria:
inclusion criteria: * without sepsis requiring tracheotomy exclusion criteria: * those who did not give their consent or declined treatment during the period of observation * those with any thyroid diseases past history, such as hyperthyroidism, hypothyroidism and thyroidtumor * those who received high-dose steroid treatment * those who received renal replacement therapy (rrt) * those with severe renal injury (scr \> 300 umol/l) * those who received antibiotic therapy from 48 hours pre-operation to 72 hours post-operation.

Keywords: tracheotomy procalcitonin sepsis
the effect of intra oral cryotherapy in patients with symptomatic apical periodontitis

Conditions: Post Operative Pain; Inflammation

Summary: the participants were divided into two groups: group i (cryotherapy) (n =10) after the completion of the mechanical preparation intra oral cryotherapy was applied. group ii (control) (n =10) received standard root canal treatment without the application of any type of cryotherapy.

1-patients selection: 20 patients with symptomatic apical peridontitis related to mandibular premolars were selected . after proper anestehsia, access cavity preparation was performed. the working length measured using apex locator. chemicomechanical preparation was done. for cryotherapy group: cold pack (ice gel enveloped by a sealed plastic cover) measuring 2.5 x 5 centimetres was placed intraorally on the vestibular surface of the treated tooth for a total time of 30 minutes. apical fluid sample was collected by paper point and the root canal was then filled using gutta percha and resin-based sealer.the access cavity was sealed using glass ionomer restoration. for the control group normal treatment was done and apical fluid was collested also before obturation.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of symptomatic apical periodontitis related to ving a mandibular single-rooted premolars * radigraphically: absence of periapical radiolucency on x ray. exclusion criteria: * the presence of any systemic disease or allergic reactions * vulnerable population: prisoners, pregnant women, mentally ill people, etc. * use of analgesic or antibiotic medication within three days * a radiographically untraceable canal

Keywords: cryotherapy substance p apical periodontitis post operative pain
extracorporeal photopheresis (ecp) after lung transplantation

Conditions: Lung Transplant Infection; Lung Transplant Rejection

Summary: the purpose of this study is to investigate the use of ecp for lung-transplanted patients to reduce the occurrence of acute and chronic rejection and cmv-infection.

the intention of the planned study is the use of ecp as a form of induction treatment in combination with standard triple-drug immunosuppressive therapy (is). this is a single-center prospective randomized controlled trial conducted at medical university of vienna between 2018 and 2020. it includes 31 copd recipients per group. treatment group underwent ecp with in addition to is after lung transplantation. control group received only is. the primary outcome was a composite outcome defined as incidence of high-grade acr, cmv infection or clad within 24 months after lung transplantation. parallel to the clinical parameters, immunologic investigations will be performed to get a better insight into the mechanisms of ecp on the immune system. the dynamics of tregs and dentritic cell will be analyzed to compare the influence of ecp vs standard is.

Eligibility criteria:
inclusion criteria: * patients undergoing first lung transplantation * patient underlying disease copd * male or female be 18 years or older * patients (male and female) must agree to use an acceptable method of birth control the treatment period of 3 months and 3 months afterward * patients must have a body weight more than 40 kg * patients must have a platelet count more than 20.000/cmm * patients must be willing and capable of understanding the purpose and risks of the study and must sign a statement of informed consent exclusion criteria: * previous organ transplantation * women who are pregnant and/or lactating * patients with hypersensitivity or allergy to both heparin and citrate products * patients who are unable to tolerate extracorporeal volume shifts associated with ecp treatment due to the presence of any of the following conditions: uncompensated congestive heart failure, pulmonary edema, renal failure or hepatic failure
glucagon-like peptide-1 receptor agonist (glp-1 ra) and diet in inflammatory bowel disease (ibd) patients

Conditions: Crohn Disease

Summary: the purpose of this study is to use diet and an injectable medication called tirzepatide (zepbound) glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist (gip-glp-1 ra) medication as adjunctive therapy (another treatment used together with the primary treatment) for crohn's disease patients with mild disease who are on stable doses of biologic medication (infliximab or adalimumab) and who have a body mass index (bmi) of at least 27.


Eligibility criteria:
inclusion criteria: * adult patients (≥18 years old) * confirmed diagnosis of crohn's disease * mildly active disease, defined by clinical symptoms using the harvey bradshaw index (hbi) score between 5 and 7 (the hbi is a continuous score ranging from 0-16 where \<4 is considered remission) * bmi ≥ 27 kg/m2 * patients will be on stable doses of medical therapy (anti-tumor necrosis factor (tnf) alpha blockers) exclusion criteria: * patients under 18 years of age * patients with ulcerative colitis * patients with infectious colitis * bmi\<27 kg/m2 * patients with type 1 or type 2 diabetes * contraindications to a gip/glp-1 ra, including patients with a personal or family history of medullary thyroid cancer or in patients with multiple endocrine neoplasia syndrome type 2 * patients already on gip/glp-1 ra therapy * patients with the following chronic symptoms: severe constipation, nausea, and/or vomiting * patients with the following medical history: small bowel obstruction in the last year, intestinal stricture, known or suspected diagnosis of gastroparesis * adults unable to consent * pregnant patients (will be confirmed via a pregnancy test) * prisoners

Keywords: inflammatory bowel disease
a randomized study of gas bubble technique in cataract surgery

Conditions: Corneal Edema After Cataract Surgery

Summary: to investigate the efficiency and safety of using "gas bubble technique" to reduce corneal endothelial damage in hard nucleus cataract patients.

the study is designed to: test the hypothesis that the "gas bubble technique" is an effective method for reducing corneal endothelial damage. describe and evaluate the effects of "gas bubble technique" on a well-defined group of patients over a 1-month period following treatment.

Eligibility criteria:
inclusion criteria: * sign the informed consent approved by the ethics committee * over 18 years of age * catract patients with hard nucleus (losiii n score ≥4) who are scheduled for phacoemulsification * feasible for all visits and willing to follow instructions from the study investigator exclusion criteria: * any ocular surgery history * currently diagnosis of severe ocular disease and under medication * uncontrolled systemic diseases
cognitive detection of preclinical ad: validation using biomarkers

Conditions: Mild Cognitive Impairment

Summary: the current study aims to validate several novel cognitive tasks expected to be sensitive to brain impairment in specific anatomic regions affected in preclinical alzheimer's disease(pad). the tasks are validated in 60 cognitively and clinically normal participants ages 60 - 85, inclusive, against reasonably well-established biomarkers of alzheimer's disease, including 1) simultaneous positron emission tomography (pet) \[18f\]flutemetamol amyloid and ct imaging and 2) to the extent data is available from other studies, participants' brain mri and cerebral spinal fluid (csf) amyloid and tau.

biomarkers, such as amyloid deposition, and hipp volume loss, and low aβ and high ptau in csf, are useful for identifying cognitively normal (cn) elderly who are likely have early ad pathology ("preclinical ad"). however, they are invasive and/or expensive. the goal of the current study is to develop and validate cognitive proxies of ad biomarkers by using cognitive tasks that are dependent on brain regions impaired by very early ad pathology. if successful, these tasks will provide a non-invasive and cost-effective way to identify and track change in cn individuals at high risk for progressing to mild cognitive impairment (mci) and dementia stages of ad and thus will facilitate future prevention trials in pad. subjects will attend three study visits. during the first study visit, subjects will have eligibility criteria confirmed, have a blood sample drawn, and complete about half of the cognitive tasks. the second visit, which will occur within one week of visit one, will involve completion of the remaining cognitive tasks. subjects will also be asked to have a pet-ct scan during visit three (to occur within 3 months of visits 1 and 2).

Eligibility criteria:
inclusion criteria: * prior enrollment as a participant in the nyu alzheimer's disease center (adc) and completion of the adc clinical evaluation within the past year. * clinical diagnosis of "cognitively normal" or "amnestic mild cognitive impairment" based on recent (within 1 year) consensus meeting cross-referenced with standard neuropsychological scores. * normal or corrected-to-normal vision and hearing (able to see images on computer screen and hear auditory events delivered through the computer speaker). exclusion criteria: * significant history of mental illness, drug or alcohol abuse; severe trauma preventing normal use of dominant hand (needed to move the mouse cursor); clinical depression (unless medically controlled); other neurologic conditions (i.e. stroke), or learning disability; ophthalmologic/visual problems that prevent viewing a computer screen at a normal distance (such as legal blindness, detached retinas, occlusive cataracts). * lack of capacity to give informed consent and no legally authorized representative to provide consent. * having pacemakers, aneurysm clips, cochlear implants, or metal/foreign objects in body and therefore, unable to receive mri. * pregnancy, breastfeeding or planning to have a baby.
prevalence of osteoporosis in korean prostate cancer patients who is receiving lhrh agonist and/or anti-androgen agent

Conditions: Prostate Cancer; Osteoporosis

Summary: prevalence rate of osteoporosis and it's actual management condition in prostate cancer patients who takes lhrh antagonist and anti androgen


Eligibility criteria:
inclusion criteria: * pathologic confirmation of prostate cancer * patients who are taking lhrh antagonist or anti- androgen or both of them within 6 months since starting. exclusion criteria: * patients who are hard to be analysed by limitation of chart record according to investigators'discretion * patients who already have been registered in this study

Keywords: osteoporosis prostate cancer lhrh agonist and/or anti-androgen agent korean prostate cancer
predictors and outcomes of in-hospital hfpef in ami patients

Conditions: Acute Myocardial Infarction; Heart Failure With Preserved Ejection Fraction; Predictor; Prognosis

Summary: this retrospective observation is to investigate the incidence,clinical outcomes and prognosis of hospitalized heart failure with preserved ejection fraction (hfpef) in patients with acute myocardial infarction(ami).

1. patients with first ami undergoing primary percutaneous coronary intervention (pci) in our hospital since january 2013 were retrospectively evaluated. the enrolled subjects were divided into two groups (ami patients with hfpef and ami patients without hf). 2. the investigator collected the clinical data of participants' demographics (age, sex), previous history,risk factors for ami (hypertension, hyperlipidemia, diabetes mellitus, smoking and stroke), laboratory biomarkers, echocardiographic measurements, clinical characteristics,medical procedures and treatments, as well as in-hospital complications. 3. two sub-investigators independently analyzed these data by using spss software.

Eligibility criteria:
inclusion criteria: * first ami patients undergoing pci with hfpef or without hf. exclusion criteria: * first ami patients with heart failure with reduced ejection fraction. * first ami patients with severe inflammatory diseases, valvular heart disease, non-cardiac caused symptoms, serious hepatic and renal failure, congenital cardiomyopathy,or pericardial diseases.

Keywords: heart failure with preserved ejection fraction acute myocacute myocardial infarction predictive factors
effect of the levamethod by bertz et al © in subjects with overweight or obesity in primary health care.

Conditions: Overweight and Obesity

Summary: this study evaluates weight loss effect of the method leva by bertz et al in subjects with overweight or obesity that are remitted to primärvårdens dietistenhet.

the method "lifestyle at effective weight loss during breastfeeding" (leva method by bertz et al) has been scientifically studied to provide sustainable weight loss for women with overweight or obesity after childbirth. primary health care centers in västra götalandsregionen treat adult patients with overweight and obesity. if the leva method by bertz et el also produces weight loss to other patient groups than women post partum, the method could be used as a treatment alternative.

Eligibility criteria:
inclusion criteria: * bmi 27 ≤ 35 * age 18-75 år exclusion criteria: * difficulty understanding swedish, spoken or read * does not manage/want to handle digital tools * the remittance was addressed to primärvårdens dietistenhet at wrong premises and the patient should be treated elsewhere.

Keywords: overweight randomized controlled trial obesity weight loss weight loss maintenance