Kornimate/medical-research-clean huggingface dataset:
imatinib in patients with desmoid tumor and chondrosarcoma

Conditions: Advanced Desmoid Tumor; Advanced Chondrosarcoma

Summary: the purpose of this study is to determine whether imatinib mesylate is active in diseases - such as desmoid tumor and chondrosarcoma - expressing the receptor for the platelet-derived growth factor (pdgf) both in its isoform alpha and beta


Eligibility criteria:
inclusion criteria: * histological diagnosis of dt or cds. * biomolecular or immunohistochemical evidence of imatinib mesylate target (kit, pdgfrα pdgfrβ activation and/or presence of pdgfα or pdgfβ) * measurable or evaluable disease * surgical resection of local disease unfeasible radically (or unaccepted by the patient, or amenable to become less demolitive, or easier, or likely more feasible, after cytoreduction) and/or metastatic disease. * ecog performance status 0, 1, 2 or 3 * adequate bone marrow, liver and renal function * female patients of child-bearing potential must have negative pregnancy test. * male and female patients of reproductive potential must agree to employ an effective method of birth control throughout the study. * written, voluntary, informed consent. exclusion criteria: * previous treatment with any other investigational or not investigational agents within 28 days of first day of study drug dosing * other primary malignancy with \<5 years clinically assessed disease-free interval, except basal cell skin cancer or cervical carcinoma in situ. * grade iii/iv cardiac problems as defined by the new york heart association criteria * severe and/or uncontrolled medical disease (i.e., uncontrolled diabetes, chronic renal disease, or active uncontrolled infection) * known brain metastasis. * known chronic liver disease (i.e., chronic active hepatitis, and cirrhosis). * known diagnosis of human immunodeficiency virus (hiv) infection. * previous radiotherapy to \>/=25% of the bone marrow or within the previous 2 months on target lesion. * major surgery within 2 weeks prior to study entry. * expected non-compliance to medical regimens (e.g. psychiatric diseases).

Keywords: pdgfr alpha pdgfr beta kit
clinical trial of fei re qing granules in the treatment of elderly community-acquired pneumonia

Conditions: Community-Acquired Pneumonia (CAP)

Summary: this study aims to evaluate the clinical efficacy of traditional chinese medicine formula granules (fei re qing granules) in the treatment of elderly community-acquired pneumonia, establish a treatment protocol, and obtain high-level clinical evidence.

this study evaluates the efficacy and safety of fei re qing granules for elderly community-acquired pneumonia (cap) through a multicenter, randomized, double-blind, placebo-controlled trial. key elements of the trial include: design: conducted across multiple centers, comparing treatment and placebo groups. participants: patients aged 65-80 years diagnosed with cap according to both western and traditional chinese medicine (tcm) diagnostic criteria. intervention: test group: fei re qing granules administered alongside standard cap treatments. control group: placebo granules matching the appearance and composition of the active granules, plus standard treatments. outcomes: primary efficacy indicator: time to clinical stability. secondary indicators: symptom improvement, hospital stay length, and imaging-based inflammation resolution. tcm-specific indicators assess syndrome improvements and integrate modern scoring methods (e.g., curb-65). study duration: two 7-day treatment cycles with 12-week follow-ups. this trial seeks to establish robust evidence for integrating fei re qing granules into tcm-based cap management strategies

Eligibility criteria:
inclusion criteria: * inpatients diagnosed with community-acquired pneumonia (cap) according to the diagnostic criteria. * diagnosed with phlegm-heat obstructing the lungs syndrome based on traditional chinese medicine (tcm). * aged ≥65 and ≤80 years, regardless of gender. * onset of illness within 72 hours. * clinical symptoms must include at least two of the following four primary。symptoms: cough, sputum production, dyspnea, and pleuritic chest pain. * voluntary participation and signed informed consent. exclusion criteria: * patients with altered mental status, consciousness disorders, dementia, or psychiatric disorders. * patients requiring invasive mechanical ventilation or endotracheal intubation. * patients with conditions such as pleural effusion, bronchiectasis, active pulmonary tuberculosis, pulmonary abscess, lung cancer, asthma, or chronic obstructive pulmonary disease (copd). * patients with neuromuscular diseases or those bedridden for long periods, posing a risk of aspiration. * patients with cancer, severe cardiovascular diseases (acute myocardial infarction, heart failure stage iii or above), or severe liver and kidney diseases (e.g., cirrhosis, portal hypertension with variceal bleeding, dialysis, or kidney transplantation). * patients participating in other drug clinical trials or known to be allergic to the study medication.

Keywords: elderly community-acquired pneumonia (cap) traditional chinese medicine randomized controlled trial fei re qing granules
novel pharmacotherapy for dual dependence

Conditions: Alcohol Dependence; Cocaine Dependence

Summary: the purpose of this study is to evaluate the effects of topiramate and cognitive behavioral therapy for the treatment of alcohol and cocaine dependence.

our objective is to understand the basic mechanisms that underpin substance dependence, and to develop efficacious treatments for individuals with comorbid cocaine and alcohol dependence. participants in this study will be randomly assigned to receive either 300 mg per day of topiramate or placebo. in addition, participants will receive weekly cognitive behavioral therapy for 12 weeks.follow-up visits will occur at 2 weeks and 1,2,, and 3 months following completion of treatment.

Eligibility criteria:
inclusion criteria: * subjects will be men and women between the ages of 18 years and older. * must meet at least three of the seven dsm iv diagnostic criteria for alcohol and cocaine dependence. * express a desire for treatment. * literacy in english and ability to read, understand, and complete the ratings scales and questionnaires accurately, follow instructions, and make use of the behavioral treatments are required. * prospective subjects must report cocaine use of at least once per month and alcohol consumption of ≥21 drinks/week and ≥14 drinks/week for men and women respectively, during the past 30 days * at least one positive urine drug screen for cocaine at screen or baseline prior to randomization. exclusion criteria: please contact site for additional information

Keywords: alcohol dependence alcoholism cocaine addiction cocaine dependence
development of organoids from primary colorectal tumors and synchronous liver metastases

Conditions: Colo-rectal Cancer

Summary: pilot feasibility study for the development of organoids from primary colorectal tumors and synchronous liver metastases, to prepare organoids from primary colorectal tumors and synchronous liver metastases. the organoids will allow us to study the function of genes targeted by the activity of the nf-y/p53 complex.

organoids will allow us to study the function of genes that are targets of the nf-y/p53 complex activity. in these organoids, we will perform overexpression and/or silencing of these genes and assays of proliferation, invasion and motility. we will also perform functional assays in cocultures of the organoids with pbmcs from the same patients. this could allow the discovery of new pathways that could be targeted by targeted therapy and/or immunotherapy. organoid preparation will be performed from fresh colorectal cancer tissue and liver metastasis following enzymatic digestion. organoid culture medium and specific organic matrix will be used

Eligibility criteria:
inclusion criteria: * patients \> 18 years * histological and cytological diagnosis of colorectal cancer neoplasia that has developed a liver metastasis * patients who are candidates for surgery for colorectal cancer with liver metastasis * signing of the relevant informed consent form. exclusion criteria: * all exclusion criteria adopted in surgical protocols will be applied to the study

Keywords: colororectal cancer organoids
effect of mulligan on sub-acromial space in patients with shoulder impingement syndrome

Conditions: Shoulder Impingement

Summary: the aim of this study is to investigate the effect of mulligan technique on sub-acromial space in patients with shoulder impingement syndrome

shoulder impingement syndrome (sis) is defined as the mechanical entrapment of the rotator cuff (mainly the supraspinatus tendon) or the sub-acromial bursa in the sub-acromial space between the humeral head and the acromion or coracohumeral ligament .it is typically exacerbate when the arm is elevated or when overhead throwing activities are performed . mulligan technique is a type of manual therapy with hypoalgesic effects, increases joint rom, enhances muscle function and treats specific pathologies. mobilization with movement (mwm) can be defined as the application of a sustained passive accessory force / glide to a joint while the patient actively performs a task that was previously identified as being problem.

Eligibility criteria:
inclusion criteria: age of patients from 30- 55 years old . both male and female. shoulder pain and two out of four specified objective signs and symptoms: positive neer impingement test. positive hawkins-kennedy impingement test. painful or limitation of active shoulder elevation (flexion, abduction, scaption). pain or limitation with the functional movement patterns of hand-behind-back or hand-behind-head. exclusion criteria: systemic or neurological disorder. adhesive capsulitis. cervical radiculopathy. history of shoulder surgery. corticosteroid injection within the past month subjects who had received physical therapy treatment for their shoulder within the past three months.

Keywords: mulligan technique sub-acromial space
mechanism of microbiome-induced insulin resistance in humans (aim2)

Conditions: Insulin Sensitivity

Summary: the purpose of this study is to determine whether microbiome modulation and an experimental reduction in plasma lps concentration improve inflammation and insulin action in insulin resistant (obese and t2dm) subjects.

in this aim we will test the hypothesis that lowering lipopolysaccharide (lps) concentration in the circulation will improve systemic (muscle) inflammation and glucose metabolism in insulin resistant (obese and t2dm) subjects by protecting the intestinal barrier with a synbiotic (bifidobacterium longum r0175 and oligofructose) or by sequestering lps in the gastrointestinal lumen with sevelamer.

Eligibility criteria:
inclusion criteria: * both genders (50%, male). all races and ethnic groups. * premenopausal women in the follicular phase, non-lactating, and with a negative pregnancy test. postmenopausal women on stable dose of or not exposed to hormone replacement for ≥6 months. * hematocrit (hct)≥ 34%, serum creatinine ≤ 1.4 mg/dl, and normal results of serum electrolytes, urinalysis, and coagulation tests. liver function tests (lfts) up to 2 times normal * stable body weight (±2%) for ≥ 3 months. * two or less sessions of strenuous exercise/wk for last 6 months. exclusion criteria: * current treatment with drugs known to affect glucose and lipid homeostasis. if the subject has been on a stable dose for the past 3 months, the following agents will be permitted: calcium channel blockers, β-blockers, ace inhibitors, angiotensin receptor blockers, and statins * history of allergy to sevelamer. * non-steroidal anti-inflammatory drugs or systemic steroid use for more than a week within 3 months. * current treatment with anticoagulants (warfarin). aspirin (up to 325 mg) and clopidogrel will be permitted if these can be held for seven days prior to the biopsy in accordance with the primary physician. * use of agents that affect gut flora (e.g. antibiotics, colestyramine, lactulose, peg) within 3 months. * history of heart disease (new york heart classification greater than grade ii; more than non-specific st-t wave changes on the ecg), peripheral vascular disease, pulmonary disease, smokers. * poorly controlled blood pressure (systolic bp\>170, diastolic bp\>95 mmhg). * active inflammatory, autoimmune, hepatic, gastrointestinal, malignant, and psychiatric disease. * history of gastrointestinal surgery or gastrointestinal obstruction within two years.
can capillary refill time variation during passive leg raising predict fluid responsiveness

Conditions: Circulatory Failure

Summary: fluid responsiveness in a context of circulatory failure can be assessed by different way. microcirculatory evaluation to assess fluid responsiveness could be interesting, but the available device are expensive and the analysis are delayed. capillary refill time (crt) is hampered by its variability. the investigators have developed a method to standardize the pressure, the length of compression and a computerized analysis to calculate the capillary refill time. this method enables accurate measure of crt. the investigators will study if crt variation induced by a passive leg raising (plr) can predict crt after a 500 ml fluid load. about thirty patients in circulatory failure with a continuous cardiac output monitoring for whom, the attending physician has decided a fluid load, will be included. hemodynamic parameters (arterial pressure, venous pressure, cardiac output), metabolic parameters (arterial and venous blood gas and lactate), microcirculatory parameters (assessed by sublingual video-microscopy) and capillary refill time measured on the thorax and on the gingival area will be recorded. data collection will be made before and after a passive leg raising and after a 500 ml fluid load of crystalloids. patients will be aposteriori sorted in two groups: responders and non responders, defined by the reduction of crt after the fluid load. the diagnosis ability of the crt variation after plr to predict in which group each patient is classified will be investigate and receiver operative characteristic curve will be built. these results will be compared to the metabolic response, the macrocirculatory response, and the microcirculatory response.


Eligibility criteria:
inclusion criteria: * the patient is equipped with an arterial and a central venous catheter * capillary refill time is measurable. * a cardiac output monitoring is available * a 500 ml fluid load as been prescribed by the intensivist in charge. * a circulatory failure is present defined as follow: patient treated with inotropic or vasoconstrictive drugs or patient presenting an hypotension defined by systolic arterial pressure less than 90 mmhg or mean arterial pressure less than 70 mmhg or a drop 40 mmhg in case of previous hypertension. with tissue hypoperfusion defined by at least one of the following item: * lactate \> 1 mmol/l * capillary refill time \> 3 s * blotch * organ dysfunction due to the circulatory failure (oligo anuria, acute lung injury / acute respiratory distress syndrome, encephalopathy) exclusion criteria: * pregnant woman * cardiogenic pulmonary edema * circulatory support : extracorporal life support / extracorporal membrane oxygenator, thoratec, heart mate. * moribund patient * intra-abdominal hypertension * lower limb amputation

Keywords: fluid responsiveness capillary refill time microcirculation circulatory failure passive leg raising
feasibility study of a modified yoga program for elders

Conditions: Depression, Anxiety; Fatigue; Pain, Chronic; Sleep

Summary: the purpose of this study is to determine whether a modified yoga program helps improve pain and function in elders age 65 years or older living in an assisted living community. participation in regular physical activity, such as yoga, may improve strength and mobility and decrease pain. this study was developed to ascertain whether a modified yoga program improves pain and function in assisted-living elders, age 65 years and older.

chronic pain is costly and debilitating, affecting an estimated 100 million americans and costing about $600 billion a year in indirect and direct medical costs. managing chronic pain is difficult, requiring an array of pharmacologic and non-pharmacologic approaches to address not only pain, but relevant and intertwined domains of life such as sleep, energy, and mood. one such non-pharmacologic therapy is yoga. systematic reviews of yoga clinical trials have shown that yoga is effective in managing low back and neck pain. however, these studies utilized younger populations, and no studies have characterized the effects of yoga for pain in the elderly. given the rapidly growing aged population, the growing popularity of yoga, and the high prevalence of pain conditions among elderly individuals, studies that examine the effect of yoga on acute and chronic pain in the elderly are warranted. thus the purpose of this proposal is to perform a pilot study to assess the feasibility and efficacy of yoga for managing chronic pain in elderly adults. this study will characterize whether such an intervention is feasible, assess whether a gentle yoga intervention improves subjective symptoms of pain, and investigate whether this yoga interventions decreases use of as needed pain relievers among elderly adults. this pilot study will characterize these effects in a sample of 60 elderly adults in at the united methodist retirement community in chelsea, michigan. the results of this study will be immediately translatable to members of this community in the short term, and nationwide in the long term.

Eligibility criteria:
inclusion criteria: * report chronic (\>3months) clinically relevant pain, defined as a score of ≥3 on a 0-10 numeric pain scale, at least 3 of 7 days per week * must be current resident of the united methodist retirement community or silver maples assisted living community with medical record availability regarding medication use over the previous 10 weeks exclusion criteria: * persons who have not lived at the facility long enough to analyze their medical records * having any medical condition or lack of physical capability that would prohibit safe participation in yoga exercise * no regular yoga practice (regular yoga practice defined as ≥1 practice session/week) * cannot provide informed consent for study
comparative effects of big toe flexor and calf strengthening exercises on medial arch in athletes with flat foot

Conditions: Sports Physical Therapy

Summary: flexible flatfoot is common in young adults. one of its causes is the failure of dynamic stabilizers, which play an important role in the medial longitudinal arch support, and their appropriate function is necessary for the integrity of the lower extremity and the spine. the metatarsal phalangeal joint (mpj) and its crossing toe flexor muscles (tfm) represent the link between the large energy generating leg extensor muscles and the ground. asymptomatic flat foot deformity is associated with gastrocnemius muscle tightness and a higher prevalence of gastrocnemius and soleus tightness was found in female subjects compared with males. the study will be a randomized clinical trial. the study will be conducted in pakistan sports board (psb) lahore. the sample size will be calculated by convenience sampling technique. the inclusion criteria will be participants of age between eighteen and thirty years old. both male and female participants will be included. athletes involved in sports more than one year and with asymptomatic flexible flatfeet (ndt \> 10mm) will be included. navicular drop test, foot function index questionnaire, arch height index, toe/hip dynamometer and vertical jump test will be the tools used for assessment and evaluation. participants who meet the inclusion criteria will be divided into two groups. baseline measures and eight-week assessment of navicular drop test and arch height index will be taken. strength of toe flexors will be evaluated with toe dynamometer. participants who will meet the inclusion criteria will be provided with ethical consent forms and after baseline assessments, exercise program will be guided. group a will perform big toe flexor strengthening exercises in addition to the sports plan they already follow. group b will be assigned with calf strengthening exercises in addition to the plan they are following. eight-week intervention program will be provided that will include warm up, therapeutic exercises including toe raises, towel curls and therapeutic band exercises, and then cool down period that includes stretching exercises.

the main objective of the study is to apply big toe flexor and calf muscles strengthening exercises and to compare the results to identify their influence on medial longitudinal arch in flexible flat foot athletes.

Eligibility criteria:
inclusion criteria: * age between 18 and 30 years' old * both male and female * athletes involved in sports with more than one year * athletes with asymptomatic flexible flatfoot (ndt \> 10mm) (5) exclusion criteria: * congenital flatfoot * athletes using foot orthoses * any lower limb muscle injury or trauma in the past 6 months * had undergone lower limb surgery * had lower extremity deformities: pes cavus, pes equinus, hallux valgus with greater angle than 15°, or clubfoot.(5) * had a sign of neurological deficit over the lower extremities. * female subjects if they were pregnant.

Keywords: dynamometer calf muscle flatfoot muscle strength big toe
primary and secondary ventral hernia repair using long-term resorbable versus non-resorbable large pore synthetic mesh.

Conditions: Primary and Secondary Ventral Hernia

Summary: since abdominal wall hernia repair is currently performed with the use of a mesh, side effects associated with the mesh are frequently reported during long term follow-up. these side effects are related to shrinkage of the mesh, adhesions to the bowl, pain, and inflammation of the skin and bowl. to reduce or prevent these effects, a fully resorbing mesh has been developed, which provides sufficient support and strength to allow efficient recovery of the abdominal wall, but also disappear from your body in three years time, so that you no longer have any synthetic material in your body. previous resorbing meshes also disappeared but over a much shorter period of time, so that the hernia was insufficiently healed, with recurrence as a result. the tigr™ mesh (the resorbable mesh used in the study) is in principle a synthetic mesh, made of two commonly used polymers, however it will retain 50% of its initial strength after six months. this in theory is enough to provide support of the collagen healing process during the initial wound-healing phase, but also to support the transition of initial collagen to functional collagen. the aim of this study is to compare tigr™ with large pore mesh used in the repair of the anterior abdominal wall repair (incisional hernia, umbilical hernia, etc..inguinal hernias are not part of the study). therefore the patients will be divided into two groups, one group will be treated with a resorbing mesh, the other group will be treated with a permanent mesh. otherwise there will be no difference in the medication or the surgical techniques used.


Eligibility criteria:
inclusion criteria: * primary and secondary ventral hernia * less than 20 cm in length * less than 6 cm in width exclusion criteria:

Keywords: ventral hernia