Kornimate/medical-research-clean huggingface dataset:
the relationship between the differential expression of fosb protein in laryngeal cancer tissues and clinical prognosis

Conditions: Laryngeal Carcinoma

Summary: to determine whether there is statisstical difference in fosb (fbj murine osteosarcoma viral oncogene homolog b) protein expression between laryngeal cancer tissue and adjacent tissue through immunohistochemistry methods. if there are differences, further the investigators will collect relevant patients information,such as clinical stages, pathological types, clinical prognosis and so on. ultimately analyze whether it is related to the expression of fosb in laryngeal cancer tissue and adjacent tissues

first,the investigators will collect 100 to 200 cases of laryngeal cancer patients who have been finally diagnosed and treated in our institution in the past five years. laryngeal cancer pathological tissues and adjacent tissues will be selected to make pathological sections. use immunohistochemistry to confirm the differences in fosb protein between laryngeal cancer tissues and adjacent tissues, and clarify whether there are differences. secondly,if there are differences, further the investigators will collect relevant patients information,such as clinical stages, pathological types, clinical prognosis and so on. review the clinical data of corresponding patients, including age, gender, smoking and alcohol history, clinical stages, pathological types and clinical prognosis, etc., and compare whether there are statistical differences. finally, clinical prognostic data of relevant patients were collected through outpatient follow-up, online and telephone follow-up, to determine whether there is a correlation between fosb expression in laryngeal cancer tissue and clinical prognosis.

Eligibility criteria:
inclusion criteria: * laryngeal squamous cell carcinoma was diagnosed ,and biopsy was confirmed by two pathologists; * primary tumor of laryngeal ,and there was no distant metastasis; * standard treatment such as surgery and preliminarily-diagnosed parients; * full clinical and pathological data information and good follow-up; * there was no previous fatal diseases such as complicated tumors. exclusion criteria: * secondary cancer or cancer with distant metastasis; * patients who have not seen a doctor for the first time or have received surgery or radiotherapy or chemotherapy in other hospitals; * clinical and pathological data were missing and loss to follow-up; * patients who abandoned treatment or standard treatment procedures has not been completed; * the past medical history of other lethal diseases such as complicated tumors.

Keywords: laryngeal cancer fosb(fbj murine osteosarcoma viral oncogene homolog b) gene immunohistochemistry cox regression analysis
study of emotional regulation and underlying prefrontal activity in binge eating disorder

Conditions: Binge-Eating Disorder; Emotional Eating; Healthy Volunteers

Summary: the goal of this exploratory, interventional, multicentre study is to compare the prefrontal activity during a negative emotion regulation task in women with binge-eating disorder (bed) and healthy women with and without emotional eating (ee). the aim of this study is to compare the prefrontal processing of cognitive control of emotions between bed and ee and to compare the emotional processing and emotional experience between bed and ee. the study will thus compare four experimental groups: patients with bed, bmi-matched healthy volunteers with ee, bmi-matched healthy volunteers, and healthy volunteers of normal weight without bed. participants will perform a down-regulation task of negative emotions elicited by negative pictures. during this task, their cerebral activity will be recorded using functional near-infrared spectroscopy (fnirs), as well as their autonomous activity (skin conductance, pulse rate, respiration rate).


Eligibility criteria:
inclusion criteria: * women between 18 and 60 years old (including 60) * right-handed. * for patients only : diagnosed with binge eating desordors according to dsm criteria. * membership of a french social security scheme or beneficiary of such a scheme. * non-opposition of the subject to participate in the study. non inclusion criteria: healthy volunteers only : * suffering from an eating disorder or any other psychiatric disorder. * history of bariatric surgery. all subjects (healthy volunteers and patients) : * rare obesity (genetic or syndromic). * specific addictions (substances or behaviors). * neurological disorders and/or history of stroke or head trauma. * presence of lesions, wounds or dermatitis at the sites where the recording devices are applied. * any serious acute or chronic illness other than the pathology under study, or any treatment likely to interfere with the evaluation of the parameter under study. * inability to follow protocol requirements. * subject unlikely to cooperate with the study and/or poor cooperation anticipated by the investigator. * subject unable to speak french and/or unable to read. * pregnant or breast-feeding women. * persons deprived of their liberty by judicial or administrative decision; persons under compulsory psychiatric care; persons admitted to a health or social institution for purposes other than research.

Keywords: binge-eating disorder emotion regulation fnirs prefrontal cortex eating disorder emotional eating
intrathecal morphine versus intravenous methadone for postoperative analgesia following retroperitoneal lymph node dissection.

Conditions: Testicular Cancer

Summary: this randomization study is to compare both intrathecal morphine and intravenous methadone, which are both standard of care, for pain management in patients undergoing retroperitoneal lymph node dissections for primary testicular cancer. investigators plan to compare their analgesic effectiveness at different postoperative time intervals.

in this study, investigators aim to compare intravenous methadone combined with standard multimodal analgesia and surgical infiltration of local anesthesia to intrathecal duramorph with standard multimodal analgesia and surgical infiltration of local anesthesia. in this single blinded prospective randomized control trial, investigators hypothesize that intravenous methadone will provide a significant reduction in patient opioid consumption when compared to intrathecal opioid analgesia in the first 24 hours in patients who undergo pc/rplnd.

Eligibility criteria:
inclusion criteria: * patients undergoing a virgin (chemotherapy has not been used) or post- chemotherapy retroperitoneal lymph node dissection for primary testicular cancer at iu health aahc * asa class 1, 2, 3 * age 18 to 80 years; male * bmi less than 50kg/m2 exclusion criteria: * any contraindication for neuraxial analgesia * patient on home methadone at any dose * any physical, mental or medical conditions which, in the opinion of the investigators, may confound quantifying postoperative pain resulting from surgery. * known true allergy to the study medications (morphine, bupivacaine, acetaminophen, methadone) * any history of substance abuse in the past 6 months which would include heroin or any other illegal street drugs * end stage liver disease, end stage renal disease * patient staying intubated after surgery * patient (home dose) taking more than 30mg po morphine equivalent (pme) per day * any additional surgical procedures to the patient with a different surgical incision compared to the standard laparotomy for the rplnd procedure, i.e. thoracic tumor reduction
evaluation of the motor activity, cardiopulmonary performance capacity and quality of life in patients born with a congenital abdominal wall defect

Conditions: Abdominal Wall Defect

Summary: the two most common congenital abdominal wall defects (awd) are gastroschisis and omphalocele. prenatal detection is often possible and the defects are differentiated by the presence or absence of a sac around the eviscerated organs. a omphalocele occurs in 0.6-4.8 in 10,000 live births compared to 4.5 in 10,000 live births with gastroschisis. in the last years a rising incidence of gastroschisis has been shown worldwide. both forms of awds necessitate early surgical intervention, mostly in one or two stages, and support at an intensive care unit in the first days of life. additionally, patients need parenteral feeding in the first weeks of life. the outcome depends on the size of the defect and on the associated malformations. the literature about long-term outcome of these malformations is scarce. some publications have reported long-term complications like redo-surgical procedures because of fascial gaps or umbilical or incisional hernias. furthermore, stool irregularities, abdominal pain and several admission to the hospital due to ileus or sub-ileus have been described. additionally, half of the patients are unsatisfied with the cosmetic result. some other studies have shown that children born with an awd have the same quality of life (qol) compared with the healthy community. nevertheless, patients with awds need a standardized, structured and multimodal long-time follow-up program to be able to detect any problems early and give advice to understand their illness in order to achieve the same qol as healthy children. therefore, the aim of this dissertation will be: * to prospectively assess the motor activity, cardiopulmonary performance capacity and qol of patients treated with awds in our department * to suggest a new standardized follow-up protocol for patients born with an awd


Eligibility criteria:
inclusion criteria: * all patients born with an abdominal wall defect exclusion criteria: * mental disease
hemodynamic effects of aliskiren compared to captopril on the kidney in healthy volunteers on a low- and high- sodium diet

Conditions: Hypertension

Summary: this study will measure the effects of different doses of aliskiren on kidney blood flow and function in healthy adults and determine how salt intake affects the response to aliskiren.


Eligibility criteria:
inclusion criteria: * healthy male and female subjects age 18 to 75 years of age included * strictly adhere to provided diet. exclusion criteria: * symptomatic low blood pressure * prescription medications, including those for blood pressure control, birth control pills, and any other medication that could affect kidney function * over-the-counter medication 2 weeks before study start * clinically significant heart abnormalities. * previous history of allergy to the study drug or drugs similar to the study drug. * any surgical or medical condition which might significantly alter the action of a drug (for example, absorption, distribution, metabolism or excretion) or which may jeopardize the subject in case of participation in the study. other protocol-defined inclusion/exclusion criteria apply

Keywords: aliskiren, renal hemodynamics, hormonal response, renin pathway, raas biomarkers
facbc positron emission tomography/computed tomography(pet/ct) used in the diagnosis of primary prostate cancer

Conditions: Prostate Cancers

Summary: the purpose of this research project is to test if a compound (chemical substance) has a natural tendency to go to prostate cancer. this compound has a small amount of radioactivity attached to it and is called a radiotracer. the name of the radiotracer is facbc and can be detected on a special imaging device called a pet scanner (positron emission tomography). the radiotracer is treated in the body much like an amino acid which is a nutrient required for normal functioning. tumors also use these nutrients. earlier studies have shown that this radiotracer may be able to detect prostate cancer. the investigators will perform a study with 20 patients in whom they know have prostate cancer after a biopsy and who are scheduled for an operation in which the prostate is removed and the nearby lymph nodes are examined. this operation is called prostatectomy. the investigators think that this radiotracer can help us determine where exactly the prostate cancer is present in the prostate or if it has spread. this information may be useful in the future to help with other non-surgical therapy such as radiation beam therapy. the investigators will compare the results of the facbc pet scan to the results of the pathology analysis of the removed prostate. in this way the investigators can determine how good a test facbc pet is for finding out where and if prostate cancer is located in the prostate or nearby lymph nodes. the investigators will also do more advanced analysis on the biopsy samples to see if they can tell why facbc goes into prostate cancer cells. this radiotracer has been tested in over 100 human subjects without incident. it has also been chosen by the national institutes of health (nih) as a promising radiotracer. the nih is funding this study.


Eligibility criteria:
inclusion criteria: * patients must be 18 years of age or older. * patients will be scheduled for prostatectomy based on a diagnosis of primary prostate cancer. * ability to lie still for pet scanning * patients must be able to provide written informed consent. exclusion criteria: * age less than 18 * inability to lie still for pet scanning * cannot provide written informed consent. * less than 4 weeks since any prior prostate biopsy (to decrease false positive uptake from inflammation).
an innovative probiotic product with antiallergic properties

Conditions: Atopic Dermatitis; Food Allergy; Effects of Probiotics

Summary: allergic diseases are currently one of the most important problem in medicine. research confirms that probiotics administered during the formation of the intestinal ecosystem and the maturation of the immune system can positively influence the development of antiallergic mechanisms. the aim of the present randomized, double-blind, placebo controlled study was to evaluate the efficacy of the mixture of probiotic lactobacillus rhamnosus łock 0900, lactobacillus rhamnosus łock 0908, and lactobacillus casei łock 0919 in children up to the age 2 with atopic dermatitis and food allergy to cow's milk proteins. children received the mixture of lactobacillus strains for 3 months every day in the daily dose of a billion bacteria or a placebo (maltodextrin). primary outcomes included the effects of probiotic treatment on the severity of symptoms assessed with scoring atopic dermatitis (scorad) index. secondary endpoints included assessment of total ige and selected cytokine levels. cytokines were evaluated in supernatants obtained from peripheral blood cultures of randomly selected 20 patients from each group. the primary and secondary outcomes were assessed at 3 time points: at baseline, after the finishing the administration of probiotic/placebo, and after 9 months of follow up.


Eligibility criteria:
inclusion criteria: * diagnosis of atopic dermatitis according to hanifin and rajka criteria, * age under 2 years (24 months) * the scorad index \>10 * suspected allergy to cow's milk protein exclusion criteria: * acute infections of skin, * presence of other severe diseases * treatment with systemic corticosteroids * treatment with antibiotics for at least 6 weeks prior to study enrollment * use of probiotics for the last 6 weeks prior to study enrollment
high intraocular pressure after cataract surgery

Conditions: Cataract; Intraocular Pressure

Summary: effectiveness of anterior chamber drainage on the structure of the anterior chamber, the position of the intraocular lens and the shape of the corneal incision in the early stage of cataract surgery with high intraocular pressure

to explore the effect of different degrees of anterior chamber drainage on the structure of the anterior chamber, the position of the intraocular lens and the shape of the corneal incision in the early stage of cataract surgery with high intraocular pressure

Eligibility criteria:
inclusion criteria: 1. patients over 60 years old who underwent simple age-related cataract surgery in eye hospital of wenzhou medical university, the operation was successful, and there were no intraoperative complications such as posterior capsule rupture; 2. measurements were taken before and after drainage, and all data were complete ; 3. the patient agrees and accepts the study. exclusion criteria: 1. preoperative glaucoma, ocular hypertension, iritis, uveitis and other eye diseases, as well as other eye diseases and serious systemic diseases that may affect the prognosis of surgery, such as corneal lesions, vitreous volume blood, retinal detachment, poor blood sugar control in diabetes, etc. 2. previous history of eye trauma, etc. 3. cannot cooperate with the completion of intraocular pressure measurement and casia2 examination.
fasting-mimicking diet intervention on side effects of aromatase inhibitors treatment in patients with breast cancer

Conditions: Breast Cancer

Summary: the primary endpoint of this study is to determine whether cycles of short term fmd exposure to a fasting-mimicking diet is effective in reducing total cholesterol levels.

the short term fmd exposure to a fasting-mimicking diet reduce total cholesterol levels

Eligibility criteria:
inclusion criteria: * age ≥ 18 years * who performance status score 0-2 * early stage breast cancer, er positive, receiving an adjuvant endocrine treatment with aromatase inhibitor * hypercholesterolemic (total cholesterol \&gt;200mg/dl) * ongoing treatment with aromatase inhibitors (at least six months of drug exposure) * adequate renal, hepatic, and hematopoietic function * written and informed consent for biomaterial submission and participation in the clinical trial * compliance with treatment and follow up protocol * no other investigational agent may be administered concurrently to patients enrolled in this trial * patients with skeletal pain are eligible if bone scan and/or rx examination fails to disclose metastatic disease * the interval between the onset of systemic adjuvant therapy with ais and the randomization should be at least 6 months * patient is accessible geographically for follow-up and must be able to provide dietary data via telephone recalls * must be medically able to accept either dietary supplementation group prior to randomization. exclusion criteria: * underweight (bmi \&lt; 18.5 kg/m2) * current or past eating disorders identified with the scoff questionnaire (useful eating disorder screening questions) \[19\] * malnutrition universal screening tool (must). it considers body mass index, weight change and acute disease effect equally and determines a malnutrition risk score. a score ≥1 identify a patient at moderate risk of malnutrition; * treatment with any investigational or non-registered drug other than the study product(s) within 30 days preceding the first dose of study product, or planned use during the study period * use of statins or supplements similar to statins (e.g red rice) or other drugs that interfere with lipid absorption (e.g ezetimibe) * known to have difficult-to-control hypertension, coronary artery disease, arrhythmia requiring treatment, clinically significant valvular disease, cardiomegaly on chest x-ray, ventricular hypertrophy on ecg, previous myocardial infarction, or congestive heart failure patients with diabetes are not eligible for the study * history of allergic reactions likely to be exacerbated by any component of the investigational product used in the study * other concurrent, severe medical problems, unrelated to the malignancy, that would significantly limit full compliance with the study or expose the patient to unacceptable risk * previous or concomitant malignancies at other sites, except effectively treated malignancy that is considered by the investigator to have been cured * psychiatric or addictive disorders that may compromise the ability to give informed consent or to comply with study procedures.

Keywords: fasting-mimicking diet
safety and efficacy of izn-6n4 oral rinse for the prevention of oral mucositis in patients with head and neck cancer

Conditions: Oral Mucositis

Summary: the purpose of this study is to determine whether an oral rinse composed of botanical extracts is effective in the prevention of severe inflammation of the lining of the oral cavity caused by chemotherapy and radiation therapy for head and neck cancer.


Eligibility criteria:
inclusion criteria: * diagnosis of head and neck cancer * planned treatment course to include cisplatin and radiation therapy, cumulative prescription dose between 50-70 gy * able to eat at least soft solids * normal cardiac function * able to perform oral rinse exclusion criteria: * induction chemotherapy regimen * life threatening allergic reaction to food and/or drugs * history of any other primary malignancy diagnosed within the past 5 years * prior radiation to the sites to be treated * active infections of the oral cavity

Keywords: oral mucositis chemoradiation head and neck cancer
analysis of knee joint of patients with anterior cruciate ligament injury undergoing physiotherapy after two different surgical techniques: a randomized clinical trial.

Conditions: Anterior Cruciate Ligament (ACL) Tear; Anterior Cruciate Ligament Reconstruction Rehabilitation

Summary: the objetive is compare knee joint stability, functional capacity, postural control, activation, and muscle strength of patients undergoing conventional anterior cruciate ligament reconstruction or the conventional anterior cruciate ligament reconstruction + anterolateral ligament reconstruction technique of the knee, and rehabilitation for up to nine months. this project aims to include patients with acl injuries already treated at the knee outpatient clinic of the hospital das clínicas da uel (hc-uel), coordinated by the orthopedic physician dr. lucas da fonseca borghi, who has his master's degree related to this research project. twenty patients between 18 and 50 years old, of both sexes, sedentary and/or active and/or athletes, diagnosed with unilateral injury of the anterior cruciate ligament will be included. these patients will be evaluated, submitted to acl surgery (conservative) or associated with all reconstruction and undergo rehabilitation with physiotherapy in conjunction with the extension project sports physiotherapy from theory to practice - phase iii (proex-uel no 02675), coordinated by prof. dr. christiane s. guerino macedo - advisor of this research. expected results: it is expected that the group undergoing acl + all reconstruction will present better knee joint stability, functional capacity, postural control, activation and muscle strength.


Eligibility criteria:
inclusion criteria: - participants with 18 to 50 years old; - both sexes; - sedentary; -active; - athletes; - diagnosed unilateral acl injury; - patients residing in the city of londrina - pr. exclusion criteria: - bmi (body mass index) above 35 kg/m2; - multidirectional ligament laxity; - associated multiligament injury (pcl and posterolateral corner); - previous or current lower limb fractures; - previous acl reconstruction (revision); - signs of osteoarthritis; - indication for meniscus suture; - neurological disease; - pregnant women; - heart disease; - previous lower limb surgeries.

Keywords: knee knee injuries anterior cruciate ligament reconstruction physiotherapy