Kornimate/medical-research-clean huggingface dataset:
safety and efficacy of the percutaneous intervention performed with devices of a single-brand

Conditions: Atherosclerotic Heart Disease; Coronary Heart Disease

Summary: the freedom of choice in medicine is based on the physician's ability to treat their patients with the best available therapy. the armamentarium for percutaneous intervention is frequently determined on the basis of subjective criteria and the experience of the interventional cardiologist. the evaluation of devices used in coronary intervention, especially angiography and its clinical outcomes, has rarely been investigated; the exceptions are studies on stents. therefore, the freedom of choice for the interventional cardiologist has been challenged, especially because of cost restrictions. this way this study aims to assess the safety and efficacy of a device of a single brand in performing percutaneous transluminal coronary angioplasty (guide catheters, guidewires, balloons, and stents) in selected patients.


Eligibility criteria:
inclusion criteria: the study included both male and female patients for stent implantation referred for angioplasty of coronary arteries with more than 18 years. exclusion criteria: * chronic total occlusion angioplasty, * saphenous graft angioplasty, * bifurcation angioplasty (lateral branch greater than 1.5 mm) * plans to perform angioplasty on more than one vessel during the same procedure * and primary angioplasty in acute myocardial infarction
behavioral management and psychological well-being

Conditions: Psychological Well Being; Behavioral Management

Summary: the aim of present study is to evaluate whether a program of behavioral and cognitive procedures for emotional control, and assertive training, produces well-being and improvement in quality of life of healthy volunteers.

healthy volunteers,not presenting neurologic or psychiatric disorders, 18 years or older,both genders, were selected, after a medical examination, to participate in the study. in a randomized controlled trial, the volunteers were submitted to sessions of muscle relaxation (autogenic method), progressive self-focus meditation, and cognitive-behavioral training in self-control of negatives feelings. they were also trained to determine goals and to determine each step to reach them (plan of action).the volunteers have to apply this strategy to control emotional behavior and improve interpersonal relationship. anxiety and depression scores will be determined using the beck self evaluation scales (bdi and bai); quality of life will be determined using who-qol inventory and the ryff scale will be used to measure psychological well-being.

Eligibility criteria:
inclusion criteria: * healthy people, without neurological or psychiatry disorders, according to the results of a medical examination * 18 years or older * high school degree exclusion criteria: * severe neurological or psychiatric disorders

Keywords: well-being life management program breathing meditation cognitive-behavioral training
low dose weekly docetaxel versus pemetrexed in previously treated advanced non-small-cell lung cancer

Conditions: Non Small Cell Lung Cancer

Summary: docetaxel and pemetrexed have been validated for previously treated advanced non-small cell lung cancer (nsclc); however, tolerability is a concern with the docetaxel (tri-weekly 75 mg/m2 schedule). the investigators conducted this study to compare the efficacy and toxicity of weekly low-dose docetaxel versus tri-weekly pemetrexed for previously treated advanced nsclc.

we have been following a schedule of weekly low dose docetaxel (30 mg/m2 on days 1 and 8 every 3 weeks; 60 mg/m2 accumulated dose for each cycle) at our hospital in an effort to achieve better tolerability. we therefore performed an exploratory study, by statistical analyses, to investigate the efficacy and toxicity of such a low dose docetaxel schedule compared to that of pemetrexed in patients with nsclc who have failed previous chemotherapy.

Eligibility criteria:
inclusion criteria: * stage iiib or iv nsclc * previous treatment with chemotherapy or tyrosin kinase inhibitor * performance status less than 2 exclusion criteria: * age less 18 years * pregnancy * performance status 3-4

Keywords: pretreated failure advanced stage iiib/iv nsclc
low back pain and motor control in soccer players

Conditions: Chronic Low-back Pain

Summary: identification of the effects of low back pain and motor control influence on soccer players performance.

at least 60 volunteer athletes who playing soccer at least 3 years, not away from field more than 2 weeks, 16 years and older are planned to include this study. all participating athletes in this study will be signed an informed consent form then their demographic information will be recorded. to evaluate disability due to low back pain, musculoskeletal problems and the willingness to participate in sports will be used the oswestry disability index, the nordic musculoskeletal system questionnaire and the sport motivation scale-2, respectively. the motor control levels of the athletes will be assessed with the motor control test battery (mktb), the core stability with the sahrmann's core stability test, core muscles endurance with the sport-specific endurance plank test and side bridge endurance test, the static balance with the stand stork test, the dynamic balance with the lower quadrant y balance test, postural changes with the corbin posture rating scale, the agility with the t test, speed and coordination with 4-10 shuttle run test, explosive force with long jump test, the kinetic chain with the functional movement screen.

Eligibility criteria:
inclusion criteria: * be over 16 years old, * participating in the soccer training for at least three years, * soccer players who have not stayed away from their sport for more than two weeks exclusion criteria: * any history of orthopedic or neurological injury or pain that may interfere with normal football training or competition during assessment * history of spine/lower and upper extremity surgery, * structural deformities such as scoliosis and kyphosis, * having trap neuropathy * soccer players who had injuries other than chronic low back pain in the last 6 months will be excluded from the study.

Keywords: soccer motor control balance agility performance coordination speed functional movement screen
the efficacy and safety of "bst104" (lonicera flos extract) in mild to moderate functional dyspepsia subjects

Conditions: Functional Dyspepsia; Irritable Bowel Syndrome

Summary: this study was conducted to prove the efficacy of bst-104 in patients with mild to moderate fd.

in this single center, double-blind, randomized clinical trial, patients diagnosed with fd using rome iii criteria were allocated to either test group (300 mg of bst-104, containing 175 mg of flos lonicera extracts, twice daily) or placebo group (300 mg placebo, twice daily). male and female patients \> 19 years of age who had mild to moderate fd were eligible. they had baseline endoscopic screening, and patients without active lesions (peptic ulcer disease or gastric erosions) were enrolled. written informed consent was obtained from all participants.

Eligibility criteria:
inclusion criteria: * persons who was diagnosed with functional indigestion in adult over 19 years of age and did not require early medication was conducted with the participation exclusion criteria: * persons who is allergic to natural substances and substances * persons who need treatment for reflux esophagitis, gastric ulcer, and acute gastritis according to gastroscopy findings * persons with past history of stomach or esophagus surgery, or patients who are unable to take esophagogastroduodenoscopy * persons who continue to apply medications that can cause ulcers such as steroids, nonsteroidal anti-inflammatory drugs and aspirin (patients taking low-dose aspirin for prevention of cardiovascular disease were allowed) * persons diagnosed with malignant tumors within five years * persons who drink more than four times a week * severe liver failure (more than 2 .5 times the normal upper limit of alt, ast, γgt) * in case of a severe renal failure, including chronic or acute kidney failure * persons with uncontrolled diabetes, cerebrovascular disease, * persons diagnosed with diseases requiring surgery within three months * zollinger ellison sy n drome, esophageal stenosis, duodenal ulcer, pancreatitis, absorption disorder, or malignant disease in the gastrointestinal tract * pregnant women, nursing mothers, having plans for pregnancy * in case of participating another human study within four weeks

Keywords: functional dyspepsia irritable bowel syndrome lonicera flos gsrs antioxidant
seoul national university pituitary disease cohort study

Conditions: Pituitary Disease; Pituitary Incidentaloma; Acromegaly; Central Diabetes Insipidus; Pituitary Stalk Compression Hyperprolactinaemia; Cushing's Disease; Pituitary Tumor; Prolactinoma

Summary: the purpose of this study is to investigate the treatment and natural history of pituitary disease. we have a longstanding interest in pituitary disease including acromegaly, central diabetes insipidus, and nonfunctioning pituitary adenoma. we will continue to follow patients and recruit new patients for treatment and follow-up. blood and pituitary tumor tissue (when available through clinical care) will be saved for future analyses related to pituitary disease.

subjects for this study will be recruited if they are: 1. adults, male or female aged 18 years or older 2. have been diagnosed with pituitary diseases

Eligibility criteria:
inclusion criteria: * subjects for this study will be recruited if they are: 1. adults, male or female aged 18 years or older 2. diagnosed with pituitary diseases such as acromegaly, cushing's disease, hyperprolactinemia, nonfunctioning pituitary adenoma, pituitary stalk lesions, central diabetes insipidus, and craniopharyngiomas exclusion criteria: * patients who do not agree with the study

Keywords: pituitary diseases pituitary incidentaloma central diabetes insipidus pituitary neoplasms
the role of vitamin d3 in pediatric bronchiectasis severity

Conditions: Cystic Fibrosis and Non CF Bronchiectasis

Summary: vitamin d3 therapy was effective in decreasing the frequency of pulmonary exacerbations and preserving lung functions , thereby improving the disease severity even more in non cf than cf bronchiectasis patients

objectives: to compare the effect of vitamin d3 on modifying the disease severity in cf and non cf bronchiectasis pediatric patients. patients and methods: this was a randomized clinical trial evaluating the role of oral vitamin d3 supplementation for 6 months in forty patients with cf and non cf bronchiectasis under the age of 18 years with vitamin d deficiency or insufficiency . the primary outcome was to reach the sufficient vitamin d level. the secondary outcome was to follow up the frequency of pulmonary exacerbations and lung function after vitamin d3 supplementation.

Eligibility criteria:
inclusion criteria: * ages less than 18 years . * patients with documented diagnosis of cf (by the presence of a twice positive sweat chloride test and or paired cftr dna genetic mutations). * patients with non cf bronchiectasis diagnosed clinically and radiologically ( sweat chloride test negative) with a high resolution ct-confirmed diagnosis and clinical history consistent with bronchiectasis . * vitamin d deficient or insufficient cf and non cf bronchiectasis patients exclusion criteria: if they had * sufficient vitamin d level . * chronic lung diseases other than cf and non cf bronchiectasis , liver or renal diseases. * reported taking vitamin-d supplements or steroid therapy in the last 6 weeks.
iron absorption from lipid-based nutrient supplements

Conditions: Undernutrition; Healthy

Summary: the overall objective of this study is to determine dietary iron absorption from lipid-based nutrient supplements (lns) in apparently healthy and undernourished children. this case-control study will recruit apparently healthy children and children with uncomplicated undernutrition (age 1-3 years, n=15/group) from msambweni and the surrounding rural communities in kwale county, kenya. at the baseline visit (day 0), participants will be provided with an lns labeled with a stable iron isotope (57-fe). participants will return to the hospital 14 days later (day 14) for a blood draw. blood collected on day 14 will be used to measure iron isotope incorporation into red blood cells. blood collected at screening will be used to measure indicators of anemia, iron status, hepcidin, and inflammation.


Eligibility criteria:
inclusion criteria: * children age 1-3 years on day of screening visit * hemoglobin 8-11 g/dl on day of screening visit * undernourished \[length/height-for-age z-score (haz), weight-for-age z-score (waz), and/or weight-for-height/length z-score (whz) \< -2\] or apparently healthy (haz, waz, and/or whz ≥ -1) exclusion criteria: * severe acute malnutrition (whz \< -3) with no appetite * serious medical condition or other chronic disease besides undernutrition (e.g., hiv+, severe pneumonia, malaria) * peanut allergy or other allergy that prevents consumption of the lns * plans to move away from the study location during the study period
intrarenal pressure monitoring via flexible and navigable suction ureteral access sheath in retrograde intrarenal surgery

Conditions: Kidney Stone

Summary: this study evaluates the use of a novel intrarenal pressure (irp)-monitoring flexible and navigable suction ureteral access sheath (fans) in retrograde intrarenal surgery (rirs) for renal stones. the prospective clinical trial compares its efficacy and safety against conventional fans in 100 patients. the primary outcomes include irp monitoring accuracy, operative time, stone-free rate (sfr), and complication rates, with the aim of improving stone retrieval efficiency and procedural safety in rirs. this trial seeks to validate the innovative device's role in expanding rirs indications, especially for large renal stones.


Eligibility criteria:
inclusion criteria: 1. adult patients (18-75 years old) diagnosed with renal stones (size ≤4 cm) and suitable for retrograde intrarenal surgery (rirs). 2. willing to provide informed consent. 3. no significant renal, cardiac, or systemic diseases that may interfere with the surgical procedure or the study. 4. preoperative intravenous pyelography (ivp) showing no significant ureteral stricture. exclusion criteria: 1. patients with active urinary tract infections (utis) or fever at the time of surgery. 2. pregnancy or breastfeeding women. 3. patients with a history of severe renal disease (e.g., chronic kidney disease stage 3 or higher). 4. history of prior ureteral or renal surgery that may affect the anatomy. 5. patients with uncontrolled comorbidities such as uncontrolled diabetes, hypertension, or cardiovascular disease. 6. patients who are unwilling or unable to comply with the study protocol.

Keywords: rirs fans
ambulatory versus home blood pressure measurement

Conditions: Arterial Hypertension

Summary: this is a prospective study comparing the three blood pressure monitoring methods on the diagnosis of arterial hypertension. blood pressure of each subject will be evaluated with clinic, home and 24h ambulatory blood pressure measurements in three visits


Eligibility criteria:
inclusion criteria: * age \> 20 yrs * patients referred to an outpatient clinic for high blood pressure * patients with no treatment or with antihypertensive treatment stable for at least 4 weeks. * patients capable of performing home blood pressure measurements. * signed informed consent exclusion criteria: * hypertension stage iii (sbp\>180 mmhg or dbp\>110mmhg) * secondary hypertension * resistant hypertension * arrhythmia * pregnancy * symptomatic heart disease * renal disease (cr\>2mg/dl) * uncontrolled diabetes mellitus (hba1c\>8.5%)
probiotics in enteral feeding in critically ill patients

Conditions: Critical Illness; Dietary Modification; Probiotics; Gut Failure; Treatment Outcomes

Summary: the purpose of this study is to investigate the effect of probiotics in enteral nutrition on improving gut function, inflammatory markers and clinical outcomes in critically ill patients admitted to the intensive care unit.

gut failure in critically ill patients is common. enteral feeding is one of the preferred routes for nutrition support to maintain gut function. however, enteral nutrition is not without complications such as alterations in gut transit time and gut eco-culture. enteral nutrition supplemented with a probiotic offers a possible solution to modulating this ecosystem. objectives: the primary aim of this study was to investigate the effect of probiotics in enteral feeding on improving the gut function, inflammatory markers and clinical outcomes in critically ill patients. subjects and methods: forty-nine patients that were admitted to the intensive care unit in university malaya medical center requiring enteral feeding were randomized to receive either probiotics or a placebo. patients remained in the intensive care unit for more than 7 days and were examined prior to the start of enteral feeding and on day 8. return of gut function was assessed by the time needed to achieve caloric requirement. inflammatory markers including the white cell count and c-reactive protein levels were tested on day 1 and day 8. clinical outcome was assessed by number of days of ventilation and total days in intensive care unit.

Eligibility criteria:
inclusion criteria: * admitted to intensive care unit * expected stay of more than 48 hours * on enteral feeding * consent obtained from patient/relative exclusion criteria: * patients on immuno-suppressive drugs * patients with hematological diseases * pregnant females * do not consent

Keywords: critical illness dietary supplements gastrointestinal tract/physio-pathology
paracervical block before intrauterine device (iud) insertion

Conditions: Pain Control for Intrauterine Device Insertions

Summary: the purpose of this study is to evaluate if a paracervical block containing 1% lidocaine administered prior to iud insertion reduces insertion pain. the hypothesis is that women receiving paracervical analgesia will experience less pain during iud insertion than those who do not receive such analgesia.


Eligibility criteria:
inclusion criteria: * women age 18 -50 years * a negative urine pregnancy test and clinically unlikely to be pregnant * seeking an intrauterine device for any indication * willing and able to sign an informed consent in english exclusion criteria: * history of a prior iud successful insertion * previous failed insertion of an iud * known copper allergy * known levonorgestrel allergy * known lidocaine allergy * current cervicitis * pelvic inflammatory disease (pid) within 3 months * pregnancy within six weeks prior to iud insertion * uterine anomaly or distortion of the uterine cavity * use of any other pain medication within 6 hours prior to iud insertion * use of misoprostol within 24 hours prior to iud insertion

Keywords: intrauterine device local anesthetic
rocc knee data collection

Conditions: Arthritis of Knee

Summary: this observational study intends to collect efficacy and safety data on rocc knee system.

the rocc® prosthesis is a rotating platform with: * highly congruent surface contact, * non constrained kinematics allowing posterior roll back until 110° then anterior in hyperflexion like a normal knee * allowing asymmetric movement

Eligibility criteria:
patients suitable for knee replacement for: * osteoarthritis, * rheumatoid arthritis * bone necrosis affecting two knee compartments, * correction of genu varus, genu valgus or post-traumatic deformities, * sequelae of prior procedures.
prospective study on the role of intravenous unfractionated heparin following digital replantation and revascularization

Conditions: Amputation; Traumatic, Hand

Summary: the purpose of this study is to determine the effectiveness of therapeutic dose intravenous heparin at improving replantation/revascularization success and its indications (if any) in participants who have suffered traumatic digital amputation. digital replantation/revascularization success will be assessed in participants who receive continuous intravenous drip of thromboprophylactic heparin at a therapeutic dose (i.e. modifies inr to the desired range) contrasted to those who do not receive therapeutic dose heparin (i.e. does not modify inr to the desired range). in the study, replantation/revascularization success is defined as a clearly viable digit at the time of discharge. secondary objectives include assessing postoperative complications associated with heparin use, such as bleeding, hematoma or heparin induced thrombocytopenia. the investigators would also assess the impact of categorical variables such as smoking status, mechanism of injury and comorbidities, on digital survival.


Eligibility criteria:
inclusion criteria: * all replantation and revascularization patients who are accepted into the cevarmu program at the centre hospitalier de l'université de montréal exclusion criteria: * patients on anticoagulants, other than asa, prior to admission (i.e. coumadin, eliquis, pradaxa, plavix, or similar medications) * patients with a contraindication for heparin (e.g. coagulopathy, acute ulcers, thrombocytopenia, severe liver damage, shock) * patients who suffered an amputation in the level of the carpal tunnel and proximal to it * patients who experienced a degloving injury

Keywords: replantation revascularization unfractionated heparin finger
letrozole in patients with hepatopulmonary syndrome

Conditions: Hepatopulmonary Syndrome

Summary: the purpose of this study is to assess the safety, tolerability and possible benefit of letrozole compared to placebo in patients with hepatopulmonary syndrome.

this study is a phase ii randomized, double-blind, placebo-controlled parallel trial of 20 subjects with hepatopulmonary syndrome designed to assess the effect of letrozole 2.5 mg orally daily or placebo for 6 months on the alveolar-arterial oxygen gradient (aapo2). subjects at each site will be screened at outpatient clinic visit appointments and interested qualified subjects will be consented and offered participation in this trial. once consent has been obtained baseline values will be established and subjects will begin letrozole with follow-up clinic visits and testing at 3 months, and 6 months.

Eligibility criteria:
inclusion criteria * diagnosis of moderate to very severe hepatopulmonary syndrome which consists of having all 3 of the following conditions: * presence of liver disease or portal hypertension * intrapulmonary shunting on contrast-enhanced echocardiogram * hypoxemia \[a-a gradient ≥15mmhg (or ≥20mmhg if age \>64) and pao2\<80mmhg on arterial blood gas testing\] * child-pugh class a or b liver disease * meld score \< 20 * ≥ 18 years old * female subjects must be post-menopausal (defined as 12 months of spontaneous amenorrhea or 6 weeks postsurgical bilateral oophorectomy without or without hysterectomy) * ability to provide informed consent exclusion criteria * enrollment in a clinical trial or concurrent use of another investigational drug or device therapy (i.e., outside of study treatment) during, or within 28 days of baseline * current hepatic encephalopathy * expectation of liver transplant within six months of randomization * concomitant lung disease defined as restriction (tlc \< 70%) or obstruction (fev1 \< 80% \& fev1/fvc \< 70%) * inability to comply with the study protocol * osteoporosis * premenopausal women (those who have not reached 1 year absence of menarche) * vulnerable study population, including imprisoned individuals, or those who cannot consent on their own.