Kornimate/medical-research-clean huggingface dataset:
select-life: a research study looking at long-term effects of semaglutide in people who took part in the select cardiovascular outcomes trial

Conditions: Overweight; Obesity

Summary: participants are being asked to participate in select-life study because participants take part in the select trial. select-life study is a survey-based study that will start when the select trial ends. select-life looks at the long-term effects of participants taking part in the select trial including the trial medicine participants have been taking. when the select trial ends, participants will no longer get the medicine participants got in the study, even if participants decide to take part in the select-life study. participants will not get any specific treatment or medicine as part of the select-life study, and participants will be treated as participants normally would by their own doctor. the select-life study will last for up to 10 years after select trial ends, and participants will be asked to fill in a questionnaire about their health every 6 months.


Eligibility criteria:
inclusion criteria: * randomized into the select clinical trial (ex9536-4388) and has not withdrawn consent, regardless of level of participation, dose achieved or treatment discontinuation. * signed select-life consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol). exclusion criteria: * mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation
mitochondrial video assessment source material study

Conditions: PolG, Primary Mitochondrial Myopathy

Summary: source material collection of videos to develop the mitochondrial video assessment (mva) for patients with mitochondrial myopathies.

this observational research is being conducted to facilitate the development of 2 related, disease-specific outcome measures assessing ease of movement in pmm and polg clinical trials. the mitochondrial video assessment (mva) utilizes remote video capture to assess subtle shifts in compensatory movement patterns and measure change in function over time, and the current state questionnaire asks participants about external factors in their daily lives which may influence fluctuations in their symptoms. as part of the questionnaire, participants are asked to rate their own perception of their functional ability using a patient global impression of severity (pgi-s) scale.

Eligibility criteria:
inclusion criteria: * 16 years old and above * confirmed diagnosis of pmm or polg * ability to understand and speak english * ability and willing to consent * able and willing to participate and perform tasks while being recorded * designating a recording partner to assist with video captures is strongly advised, but not required exclusion criteria: * n/a

Keywords: poig primary mitochondrial myopathy melas cpeo
comparison of humeral or thoracic implantation of an central veinous access by an implantable venous access device in patients with solid tumors requiring chemotherapy

Conditions: Solid Tumor, Adult; Chemotherapy Treatment; Advanced or Metastasis Stage

Summary: the aim of this study is to compare the humeral and thoracic implantation of a central venous access by an implantable device in patients with solids tumors who require intravenous chemotherapy. this is a monocentric randomized study. 572 patients will be recruited for 2 years. they will be randomized either in the thoracic implantation, either in the humeral implantation due to the 1:3 randomization, 143 patients will be randomized in the humeral arm and 429 into the thoracic one. number of complications related to the implantable device, medico-economic analysis as well as patient satisfaction will be assessed. every patients with solid tumor requiring medical device implantation for intravenous chemotherapy treatment will be eligible. both humeral and thoracic implantation of medical device are standard procedures. the randomization in a specific arm is the study procedure and is considered as an interventional study in france.


Eligibility criteria:
inclusion criteria: * patients with solid tumors at an advanced or metastasis stage requiring placement of implantable catheter for intravenous chemotherapy treatment * older than 18 years * express signed consent exclusion criteria: * life expectancy less than 12 months assessed by investigator * infection or uncontrolled suspected infection * medical contraindication to port implantation by catheter in thoracic or humeral location * pregnant or lactating women * abnormal coagulation * immunosuppressed patients (for example known hepatitis b or c, or known positive human immunodeficiency virus due to the spreading risk) * patient not affiliated to the french social security * access time to the humeral or thoracic port placement higher than 15 days (from the randomization theoretical date) * protected adult or adult deprived of liberty
the effectiveness of non-invasive ventilation use in preterm infants.

Conditions: Noninvasive Ventilation; Preterm Infants

Summary: prospective observational study of snippv use in preterm infants of less than 32weeks of gestation from january 2012 to december 2015. previous respiratory status is analyzed as well as respiratory outcomes and possible secondary side effects. snippv is used to prevent intubation in infants in which ncpap has already failed (infants that met intubation criteria) and also is used electively for extubation when ncpap extubation has previously failed or infants with prolonged mechanical ventilation (more than 15 days) with high respiratory parameters (pmap \> 10 cmh2o and fio2\>35%).

snippv is used to prevent intubation in infants in which ncpap has already failed (infants that met intubation criteria) and also is used electively for extubation when ncpap extubation has previously failed or infants with prolonged mechanical ventilation (more than 15 days) with high respiratory parameters (pmap \> 10 cmh2o and fio2\>35%).

Eligibility criteria:
inclusion criteria: * preterm infants of less than 32 weeks of ga in which snippv is applied for ncpap failure. * preterm infants of less than 32 weeks of ga in which snippv is applied electively for extubation. exclusion criteria: none
multi-institutional registry for malignant peripheral nerve sheath tumors

Conditions: Malignant Peripheral Nerve Sheath Tumors

Summary: first, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (nf)1-associated malignant peripheral nerve sheath tumor (mpnst) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). a worldwide database will be established, collecting, in a standardized manner, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from centers worldwide with expertise in these nf1-related cancers. although retrospective in nature, the resulting data from this registry may reveal previously unanticipated patterns, similar to the infact effort outcome. this registry would then allow the acquisition of data associated with mpnst biospecimens collected under associated banks (frozen or paraffin-embedded, germline (or normal tissue dna) samples, and any previously somatic whole-exome or whole-genome sequencing data for aggregate analyses). second, the investigators plan to co-register patients to institutional banks in order to prospectively collect mpnst samples for analysis. these patients will be consented in order to collect the above information and for banking of tumor tissue and future studies that include genomic characterization of the tumors.


Eligibility criteria:
inclusion criteria and exclusion criteria: -any patient diagnosed with an mpnst is eligible for enrollment to this registry provided s/he consents to participate (or consent form his/her parent or legal guardian or legally authorized representative is obtained).
application of different modes of esketamine administration in pediatric day circumcision

Conditions: Pain

Summary: to explore the application of different administration modes of esketamine in pediatric day circumcision, in order to find an anesthesia scheme more suitable for day pediatric circumcision.

the current clinical study believes that esketamine is suitable for pediatric anesthesia because of its advantages of light respiratory depression, low secretions, low incidence of psychomotor reactions and fast recovery of anesthesia, but there are few related studies on its administration mode and timing in clinical application, this study aims to explore the application of different administration methods of esketamine in pediatric day circumcision, and find an anesthesia scheme more suitable for day circumcision, in order to provide new ideas for anesthesia for pediatric day circumcision.

Eligibility criteria:
inclusion criteria: * american society of anesthesiologists (asa) class i and ii children * age 5-12 years * foreskin cerclage is proposed * no history of upper respiratory tract infection in the past two weeks * obtain the consent of the child's family exclusion criteria: * hepatic and renal insufficiency, coagulation dysfunction * those who are allergic to esketamine * history of cognitive impairment * epilepsy * other psychiatric and neurological disorders

Keywords: pediatric circumcision mode of administration day surgery esketamine
promoting radon testing via smartphone app: a clinical trial in a high radon state

Conditions: Lung Cancer

Summary: this research will compare (1) the effectiveness of a mobile radon-education app (vs. traditional brochures) and (2) that of the radon app with in-app reminders (vs. the radon app without in-app reminders and the no app use with postal reminders) to increase radon awareness and testing among north dakotans. the prevalence of exceptionally high levels of residential radon in north dakota (nd), coupled with public's poor understanding of this hazard, is a critical public health problem.


Eligibility criteria:
inclusion criteria: * the principal eligibility criterion is that participants own a smartphone. exclusion criteria: * the principal exclusion criterion is previous testing for radon within the past two years.
effect of functional training and isometric exercises on pain, rom, and functional status in patients with neck pain

Conditions: Chronic Pain

Summary: work-related musculoskeletal disorders have been rising fast around the globe leading to neck pain and scapular muscle dysfunction, contributing to a decrease in neck movements and functional limitations. this study aimed to determine the efficacy of scapular functional exercise (sfe) in combination with cervical isometric exercises (cie) on neck pain, cervical range of motion, and functional limitations among participants with chronic mechanical neck pain.the study was based on a two-arm parallel group pretest-posttest randomized control trial design. thirty participants (females 21 and males 9; average age 28.94±3.77 years) were randomly allocated to groups a and b (n=15/group). the group's a and b participants received a common intervention, such as cie and hot packs. however, group a received the sfe in addition to common interventions. the outcomes, such as neck pain, cervical rom, and functional limitations, were evaluated using a numeric pain rating scale (nprs), standard universal goniometer, and neck disability index questionnaire at baseline and 4-week post-intervention. the paired and unpaired t-test was used to analyze the intervention effects on the outcomes within-group and between-group, keeping the significance level alpha set at p\<0.05.

the study hypothesised that adding the scapular functional training to the cervical isometric exercises will be equally effective than cervical isometric exercises alone on managing neck pain, cervical rom, and functional limitations among participants with chronic mechanical neck pain. the present study is helpful for chronic mechanical neck pain patients and physiotherapist to better understand the effect of incorporation of the scapular functional training in the treatment of neck pain. therefore, this protocol may be used as a treatment in chronic mechanical neck pain because it alleviates pain, neck disability, improving cervical range of motion in chronic mechanical neck pain.

Eligibility criteria:
inclusion criteria: * both male and female with aged range 22-35 years * neck pain of more than 3 months in duration * having neck pain without symptoms distal to shoulder * participant had not received any clinical treatment for their neck pain within 1-months, and * willingness to participate in the study. exclusion criteria: * having a diagnosis of cervical spinal stenosis * patients with serious pathology (e.g., neoplasm, fractures and inflammatory diseases, unilateral and bilateral upper extremity radicular symptoms (cervical radiculopathy) * prior surgery of cervical spine * evidence of nerve root compression * pregnant women, and * showed poor cooperation in the study

Keywords: chronic pain range of motion functional limitations isometric exercises functional training
effects of dietary nitrate intake on physical performance of middle-aged women

Conditions: Postmenopausal; Menorrhagia; Physical Inactivity; Motor Activity

Summary: through a randomized, crossover, triple-blind, placebo-controlled clinical trial, 15 physically inactive hypertensive women will participate a 8-day trial, each with two intervention protocols: 1) placebo and 2) beetroot; in which will ingest beet juice with or without no3 in its composition with a 8-day washout interval.


Eligibility criteria:
inclusion criteria: * 50 to 65 years old * physically inactive * postmenopausal diagnosis (amenorrhea for 12 months or more); exclusion criteria: * smoking * cardiac failure * previous history of acute myocardial infarction and/or stroke; * allergy or intolerance to nitrate, gluten, or milk;
efficacy and safety of xience in coronary arery disease all-comers after stenting using the prime platform (excellent-prime registry)

Conditions: Coronary Artery Disease

Summary: objectives: 1. to evaluate the safety and long-term effectiveness of coronary stenting with the xience primetm in a cohort of "real world" patients and lesion subsets. 2. to determine clinical device and procedural success during commercial use of xience primetm coronary stent study population : approximately consecutive 2000 patients treated with xience primetm study period * patient enrollment: 2011.05 \~ 2012.04 * end of follow-up period: 2015. 02 (3 years of follow-up) primary endpoint : target lesion failure (tlf) rate at 12 months secondary endpoint: * in-stent \& in-segment late loss at 9 months * stent thrombosis at 24 hours (acute), 30 days (subacute), 1 year (late), yearly up to 3 years (very late) * target vessel failure at 12 months (composite of cardiac death, mi, and tvr) * any death, cardiac death, mi, tlr, tvr at 30 days, 9months, 1 year, 3 years * composite rate of cardiac death and any mi up to 3 years * composite rate of all death and any mi up to 3 years * composite rate of all death, any mi (q-wave and non q-wave) and any repeat revascularization up to 3 years * compliance and therapy interruptions with prescribed adjunctive antiplatelet therapy up to 3 years * procedural success up to 1 day * angiographic success up to 1 day


Eligibility criteria:
inclusion criteria * the patient agrees to participate in this study by signing the informed consent form. alternatively, a legally authorized patient representative may agree to the patient's participation in this study and sign the informed consent form. angiographic inclusion criteria * there are no angiographic inclusion criteria for this study. exclusion criteria * there are no exclusion criteria for this study.

Keywords: everolimus xience prime drug eluting stent
efficacy and safety of early initiation of butylphthalide treatment in patients with acute ischemic stroke.

Conditions: Acute Ischemic Stroke

Summary: this study is a prospective, multicenter, randomized, open-label, blinded-endpoint trial designed to evaluate the difference in efficacy of butylphthalide sodium chloride injection treatment initiated early (\&lt;3 hours) versus late (3-6 hours) in patients with acute ischemic stroke. the aim is to determine the optimal timing window for neuroprotective therapy.


Eligibility criteria:
inclusion criteria: 1. age between 18 and 80 years, gender not specified; 2. clinically diagnosed with acute ischemic stroke; 3. stroke onset within 3 hours; 4. nihss score at enrollment between 4-25 points, with item ia ≤1 point; 5. pre-stroke mrs score ≤1 point; 6. participants and their representatives capable and willing to sign an informed consent form. exclusion criteria: 1. confirmed intracranial hemorrhage within the past 3 months, including intracerebral hemorrhage, intraventricular hemorrhage, subarachnoid hemorrhage, and subdural/epidural hematoma; 2. known severe hepatic or renal dysfunction or individuals undergoing dialysis for various reasons (severe hepatic dysfunction defined as alt levels \&gt;3 times the upper limit of normal or ast levels \&gt;3 times the upper limit of normal; severe renal dysfunction defined as serum creatinine \&gt;3.0 mg/dl \[265.2 μmol/l\] or glomerular filtration rate \[gfr\] \&lt;30 ml/min/1.73m²); 3. systolic blood pressure \&lt;90 mmhg or \&gt;220 mmhg; 4. presence of bradycardia (heart rate below 60 beats per minute) or sick sinus syndrome; 5. history of drug or food allergies, including known allergies to the components of the study medication; 6. treatment with medications containing butylphthalide following the onset of the current stroke episode; 7. congenital or acquired hemorrhagic disorders, coagulation factor deficiencies, thrombocytopenia, or similar conditions; 8. pregnant or breastfeeding individuals, or those planning to become pregnant within the next 90 days; 9. severe psychiatric disorders or dementia that preclude understanding of informed consent or compliance with follow-up procedures; 10. concurrent malignancy or severe systemic disease with a life expectancy of less than 90 days; 11. participation in another interventional clinical study within the last 30 days before randomization, or currently participating in another interventional clinical study; 12. any other reason deemed by the investigator as unsuitable for participation in the study.
acunpuncture for fibromyalgia syndrome

Conditions: Acupuncture; Fibromyalgia

Summary: patients suffering from fibromyalgia syndrome according to the criteria of the american college of rheumatology 2010 will be enrolled. all fibromyalgic patients will be subjected to a further ambulatory visit and if an energy deficiency in the liver and spleen meridians will be identified, according to the traditional chinese medicine rules, acupuncture will be planned. if not, a standard therapy with analgesic drugs will be started. acupuncture treatment will consist of six weekly sessions. tricyclic antidepressants, anti-epileptic drugs, selective serotonin reuptake inhibitors and opioids will be used as standard strategy. pain scores and fatigue impact scale will be assessed before any treatment and after a 28 days follow-up.


Eligibility criteria:
inclusion criteria: clinical diagnosis of fibromyalgia exclusion criteria: coagulation disorders pregnancy pacemaker implantable cardioverter defibrillator
internet technology based life-style and care intervention for risk factors of non communicable diseases（ncd）

Conditions: Lifestyle Intervention; Non Communicable Diseases

Summary: this study aims to control risk factors of non communicable diseases by life style and care intervention based on internet technology, looking forward to improve cardiovascular and cerebrovascular complications, diabetes and all-cause death.

cardiovascular and cerebrovascular diseases, diabetes, chronic obstructive pulmonary disease and malignant tumors are the main chronic diseases, which have been the most important cause of human death, consuming most health resources. in china, patients with cardiovascular and cerebrovascular diseases account for more than 40% of all causes of death. after half a century of research, we have a thorough understanding of risk factors of cardiovascular disease, including genetics, aging, ethnicity, physical activity decreases, unbalanced nutrition and calorie intake, smoking, obesity, hypertension, dyslipidemia, and glucose abnormalities, etc. many factors can be corrected through health education, indicating that the occurrence of chronic diseases can be prevented through lifestyle changes and the control of risk factors. this project collects risk factors of cardiovascular disease and establishes a real and reliable health database by conducting a cross-sectional survey of chronic diseases among residents of tian tong yuan district (there are hundreds of thousands of people).on this basis, community health management network was established with internet technology. meanwhile, prospective, open, community randomized and controlled lifestyle intervention studies were carried out. intervention was conducted on risk factors of cardiovascular and cerebrovascular diseases, such as smoking, obesity, hypertension, lipid metabolism disorder, and hyperglycemia. for patients with chronic diseases, lifestyle intervention and health education should be carried out to improve the diagnosis rate and control rate. the project focuses on the impact of lifestyle interventions and health education on risk factor control, cardiovascular and cerebrovascular complications, diabetes and all-cause death.

Eligibility criteria:
inclusion criteria: * men and women older than 25 years of age with two or more risk factors as follows, bmi≥24 or bmi≤18.5 kg/m2, smoking, active exercise less than 30 minutes every day, blood pressure higher than 130/85 mmhg, dyslipidemia, fasting glucose higher than 6.1mmol/l, fatty liver. * patients with hypertension, diabetes and ascvd exclusion criteria: * patients had not signed the consent form * patients with severe heart failure, hepatic failure, renal failure and malignant tumor. * patients planing pregnancy

Keywords: internet technology lifestyle intervention non communicable diseases