Kornimate/medical-research-clean huggingface dataset:
study of adherence and effects of balance exercices (siel bleu associatio)

Conditions: Gait Apraxia; Alzheimer Disease; Impaired Cognition

Summary: the purpose of this study is to measure the adherence to "siel bleu" balance exercises in patients with alzheimer's disease, while taking into account the disease stages.

the practice of physical activity, more specifically postural balance exercises, is an intervention that improves gait performance in the elderly. among patients with alzheimer's disease, it seems that physical exercice also improves cognitive performance, reduces the loss of autonomy and independence in activities of daily living. all these effects may reduce the caregiver burden. despite several initiatives in france, no study has been carried out to test the adherence to postural balance exercises and to examine the benefits on older ad patients and their caregiver. the main objective of this study is to measure the adherence to "siel bleu" balance exercises in patients with alzheimer's disease, while taking into account the disease stages.

Eligibility criteria:
inclusion criteria: * diagnosis of alzheimer's disease (ad) (dsm-iv/nincds-adrda criteria) * age ≥ 65 years old * mild ad (mini-mental state examination score between 21 and 25), moderate ad (mini-mental state examination score between 10 and 20) and severe ad (mini-mental state examination score between 3 and 9) * able to walk without any aid on 15 meters. * near visual acuity ≥ 2 * absence of severe depression (score of the 15-item geriatric depression scale ≤ 10) * written consent form to participate in the study (or trustworthy person or legal representative for severe ad) * being affiliated to a social security regime exclusion criteria: * musculoskeletal disorders not related to alzheimer's disease * near visual acuity \< 2 * history of cerebrovascular accident or other cerebro-spinal pathology * poor workmanship of the written or oral french language * refusal to be informed on possible hanging bare anomaly during study * score of mini-mental state examination \< 3 * presence of severe depression (score of the 15-item geriatric depression scale \> 10) * use of walking aid * subject suffering from pre-existing impellent disturbances * refusal to participate (or trustworthy person or legal representative)
mirror therapy combined with task- vs. impairment-oriented rehabilitation program

Conditions: Cardiovascular Diseases; Stroke; Cerebrovascular Disorders

Summary: the goal of this clinical trial is to examine the effects of mirror therapy combined with task- vs. impairment-oriented rehabilitation programs as novel hybrid approaches in individuals with stroke. participants will receive mirror therapy combined with the task-oriented rehabilitation program (mtt), mirror therapy combined with the impairment-oriented rehabilitation program (mti), or task-oriented rehabilitation program combined with the impairment-oriented rehabilitation program (ti) 90 minutes per day, three days per week, for six weeks.


Eligibility criteria:
inclusion criteria: 1. a first-ever unilateral stroke ≥3 months 2. age between 20 and 80 years 3. baseline fugl-meyer assessment upper extremity (fma-ue) score \>10 4. no severe spasticity in any joints of the affected arm 5. ability to follow the instructions 6. no participation in other studies during the study period 7. willingness to provide informed written consent. exclusion criteria: 1. serious medical problems or poor physical conditions that might be detrimental to study participation.

Keywords: rehabilitation mirror therapy
the value of feno in predicting airway eosinophilic inflammation

Conditions: Biomarkers; Airway Inflammation

Summary: to investigate and compare the value of feno, blood eos, serum tige in predicting the airway eosinophilic inflammationin chronic cough, asthma and copd.

cough is the most common complaint in the respiratory department, while asthma and chronic obstructive pulmonary disease(copd) are two major respiratory disease that seriously endanger human health. the common test to identify the cause and evaluate the therapeutic effect such as induced sputum, pulmonary ventilation function test, bronchial provocation test, etc. are time-consuming and laborious. there is an urgent need for an easily detectable index in the clinic to quickly identify airway eosinophilic inflammation in chronic cough, asthma and copd, which will provide important guidance for clinical treatment. as a new marker of airway inflammation, exhaled nitric oxide(feno) can reflect eosinophilic airway inflammation. mean while, feno has the advantages of non-invasive, simple operation, time-saving, labor-saving, and good reproducibility, which is suitable for clinical application. this prospective, multi-center study aims to explore the value of feno in predicting airway eosinophilic inflammation and compare it with blood eos and tlge in patients with chronic cough, asthma and copd.

Eligibility criteria:
inclusion criteria: * candidates voluntarily participate in and abide by the relevant regulations of the study, can cooperate with corresponding inspections, follow the follow-up plan, and voluntarily sign written informed consent. * patients with chronic cough 1. coughing lasting ≥ 8 weeks, 2. there is no obvious abnormality in the chest x-ray 3. no clear history of upper respiratory tract infection in the past 4 weeks, 4. newly diagnosed or untreated in the last 4 weeks 5. non-smokers. * patients with asthma 1. for newly diagnosed and previously diagnosed asthma patients, the diagnosis criteria for asthma: 2. including various disease severity (mild, moderate, severe), various disease states (chronic duration, acute exacerbation period). 3. non-smokers. * patients with copd 1) including patients in stable phase and acute exacerbation phase. exclusion criteria: * diagnose patients with aco; * those who cannot cooperate with the completion of research-related test, follow-ups and other reasons cannot cooperate with the progress of the research; * combined with serious diseases of other systems (such as cardiovascular, metabolic, immune, neurological, etc.). with other diseases of the lung, including bronchiectasis.
the cholelithiasis in adults with short bowel syndrome

Conditions: Short Bowel Syndrome

Summary: short-term studies have shown that patients with short bowel syndrome (sbs) often develop cholestasis or cholelithiasis. in this retrospective cohort study, we aimed to define the incidence, risk factors, and clinical consequences of cholelithiasis in adults with sbs over an extended time period.

however, only limited data are available regarding cholelithiasis in patients with sbs. the prevalence of cholelithiasis in patients with sbs has been reported only in two studies. furthermore, few studies have focused on identifying the risk factors for cholelithiasis in patients with sbs. considering the marked improvements in medical care and nutrition support during the last 2 decades, the current incidence and risk factors for cholelithiasis in patients with sbs are unknown. the aim of the current study was to provide comprehensive, longitudinal, and long-term data on the incidence of symptomatic and asymptomatic cholelithiasis in a cohort of patients with sbs, in order to identify the prevalence, risk factors, and clinical consequences of cholelithiasis in patients with sbs to aid in the development of protective interventions.

Eligibility criteria:
inclusion criteria: all eligible adults diagnosed with sbs exclusion criteria: age \<18 years; history of cholelithiasis before sbs diagnosis; cholecystectomy; biliary tract obstruction or no abdominal imaging (ct, mri, or ultrasound) after sbs diagnosis.

Keywords: short bowel syndrome cholelithiasis prevalence risk factors
minimally invasive aortic root and aorta surgery registry

Conditions: Aortic Aneurysm, Thoracic

Summary: minimally invasive aortic valve (av) surgery has become widely accepted alternative to standard sternotomy. despite possible reduction in morbidity, this approach is not routinely performed for aortic surgery. evidence exists, however, on safety of this approach together with promising results regarding its long-term durability. the mirage registry is aimed to collect and analyse the data from multiple aortic excellence centres and to analyse them in numerous clinical scenarios.


Eligibility criteria:
inclusion criteria: * isolated, first time aortic root or aorta surgery exclusion criteria: * active aortic valve endocarditis, redo surgery, acute type a dissection, and concomitant cardiac procedures.
trial of omental roll-up technique on pancreato-jejunostomy anastomosis for reducing perioperative complication in patients undergoing pancreatoduodenectomy

Conditions: Periampullary Carcinoma; Pancreatic Fistula

Summary: despite the fact that pancreatoduodenectomy is the standard treatment of malignant tumor at periampullary area, the morbidity and mortality rate with intra-abdominal collection, post pancreatectomy hemorrhage, and delayed gastric emptying, is still high at approximately 50-60%. the causes of these complications usually come from post-operative pancreatic fistula. nowadays, several methods have been reported to reduce the incidence of pancreatic fistula after undergoing pancreatoduodenectomy, such as pancreatic stenting, the use of intravenous somatostatin, the use of sealant material and wrapping anastomosis by soft tissue. wrapping pancreato-jejunal anastomosis with omentum is not a complicate procedure and requires no extra treatment expenses of the patient. it has been reported this technique has been applied in the non-randomized controlled trials and their data have significantly shown that the technique could reduce pancreatic fistula rate. therefore, the researchers want to conduct an rct study to compare complication rates between omental roll-up pancreato-jejunal anastomosis and non-omental roll-up groups.

this is a rct study designed to compare the use of omental roll-up technique with non-omental roll-up technique at pancreato-jejunal anastomosis in patients undergoing pancreatoduodenectomy. the purpose of this study is to prove the hypothesis that omental roll-up technique can reduce the complication rate or pancratic fistula after pancreatoduodenectomy. this study was approved by the committee on human rights to conduct the research involving human subjects, faculty of medicine ramathibodi hospital, mahidol university. the patients are operated by experienced surgeons of hepato-pancreato-biliary unit, department of surgery, ramathibodi hospital and randomized into two groups by using the closed envelope method after completing pancreato-jejunal anastomosis. then, patients are followed-up and the data are collected for 30 days after the surgery.

Eligibility criteria:
inclusion criteria: * patients undergoing pancreatoduodenectomy from these disease, carcinoma at head of pancreas, carcinoma at ampullar of vater, distal cholangiocarcinoma, carcinoma of duodenum exclusion criteria: * unresectable pancreatoduodenectomy * patients underwent omentectomy from prior surgery

Keywords: pancreatoduodenectomy omentum wrapping roll-up whipple
transversus abdominis plane block for chronic postsurgical orchalgia

Conditions: Chronic Post-surgical Pain

Summary: the study will evaluate the effect of transversus abdominis plane block (tap) on chronic post-groin surgeries orchalgia (chronic testicular pain)


Eligibility criteria:
inclusion criteria: * the inclusion criteria were patients with chronic scrotal pain (orchialgia) that fulfilled the following criteria: 1. pain intensity ≥ 5 on the visual analog scale (vas), 2. pain that lasted for more than 3 months after groin surgeries, 3. failed conservative treatment with nonsteroidal anti-inflammatory drugs (nsaids) exclusion criteria: * the exclusion criteria were: 1. patients with other causes of scrotal pain, e.g., epididymitis, orchitis, and hydrocele, 2. patients complaining of groin infection and coagulopathy, 3. patients suffering from hypertension, ischemic heart disease, or psychiatric disorders
transplant navigator intervention to overcome barriers to kidney transplantation

Conditions: End Stage Renal Disease

Summary: compared with chronic dialysis treatment, kidney transplantation generally offers a longer life span, a better quality of life, and lower health care costs for the over 500,000 americans with end stage renal disease. despite medicare funding of virtually all kidney transplants, minority, female, and poor patients with end stage renal disease have decreased access to kidney transplantation. in prior work, the investigators identified the steps in the transplant process that are responsible for creating these disparities. these include medical suitability, interest in receiving a transplant, referral to a transplant center for a pre-transplant workup, placement on a waiting list or identification of a living donor, and receipt of a kidney from a deceased or living donor. the investigators now propose to train transplant recipients to act as transplant navigators and then test the value of using transplant navigators to help patients and providers complete these steps. the proposed community-based randomized controlled trial will involve approximately 75-100 adult hemodialysis patients at intervention dialysis facilities and approximately 75-100 patients at control facilities to compare a transplant navigator intervention with usual care over a 24 month interval. baseline evaluation will include sociodemographic and medical characteristics, specific steps completed in the transplant process, and barriers to moving forward in the transplant process. at periodic intervals, the navigator will provide tailored information and assistance to patients and their nephrologists to help them complete the tasks required at each step. the major outcome will be completion of additional steps in the transplant process. secondary analyses will examine impediments to successful intervention among subjects who fail to move forward in the transplant process despite assistance from a navigator. the proposed project will test a novel intervention that targets patients and nephrologists as they together make transplant-related decisions. future work will involve determining the impact of navigators on disparities in transplant rates, examining the cost-effectiveness of transplant navigators, and disseminating the intervention for use across the country. helping patients complete steps in the transplant process may lead not only to improved access to kidney transplantation but also to better patient survival, decreased health care costs, and increased quality of life.


Eligibility criteria:
inclusion criteria: * age 18-70 years old * english speaking * mentally competent exclusion criteria: * prior pre-transplant workup * prior kidney transplant * active systemic infection * active or recent malignancy
the effects of caffeine withdrawal on migraine

Conditions: Migraine; Caffeine Withdrawal

Summary: sporadic and chronic dietary consumption of caffeine has substantial biological effects on the nervous system. the effects on migraine are at large not known. in this study we want to assess the effects of caffeine withdrawal on migraine.

the actions of caffeine as an antagonist of adenosine receptors have been extensively studied, and there is no doubt that both daily and sporadic dietary consumption of caffeine has substantial biological effects on the nervous system. the current opinion is that caffeine both can cure and trigger headaches. caffeine is a component of many combination drugs marketed for the relief of headaches, but on the other hand it is strongly incriminated as a risk factor for developing chronic headache. withdrawal may cause symptom constellations similar to the migraine syndrome. further, caffeine consumption may affect sleep and alertness, possibly influencing the risk of migraine attacks. .

Eligibility criteria:
inclusion criteria: * migraine present for at least 1 year and fulfilling diagnostic criteria (ichd-3 beta) * =/\> 3 migraine attacks per month * no migraine prophylaxis the last month * consumption =/\> 300 mg and \</= 800 mg caffeine per day the last month * signed consent exclusion criteria: * suspicion of medication-overuse headache * pregnancy and breast feeding * serious co-morbidity or conditions requiring medical treatment or caution * working night shift * use of drugs with moderate or major interactions with caffeine
fixed combination for lipid and blood pressure control

Conditions: Arterial Hypertension; Dyslipidemias; Blood Pressure; Lipid Metabolism Disorders

Summary: the aim of this study is to compare the effect of fixed and free combination of atorvastatin/perindopril/amlodipine on blood pressure and lipid levels.


Eligibility criteria:
inclusion criteria: patients with uncontrolled arterial hypertension (the average 24h blood pressure in the range 130/80 - 180/110 mmhg and / or daytime average blood pressure in the range 135/85-180/110 mmhg) and one of the following: 1. a very high cardiovascular risk and ldl-cholesterol\> 1.8 mmol / l 2. a high cardiovascular risk and ldl-cholesterol\> 2.5 mmol / l 3. patient with a high or very high cardiovascular risk treated by lipidlowering therapy with statin exclusion criteria: 1. hypersensitivity to perindopril or to other ace inhibitors, amlodipine, atorvastatin, dihydropyridines or to or statins 2. angioneurotic edema in medical history (hereditary / idiopathic or associated with prior treatment with ace inhibitors) 3. severe hypotension, shock, including cardiogenic shock 4. hemodynamically unstable heart failure 5. active liver disease or unexplained persistent elevations of serum transaminases more than three times normal 6. women of childbearing age without reliable contraception 7. pregnancy 8. breastfeeding 9. patients with contraindications listed in the currently valid sp

Keywords: arterial hypertension dyslipidemia blood pressure control fixed combination
functional electrical stimulation in cardiac patients

Conditions: Coronary Disease; Heart Failure

Summary: the purpose of this study was to determine the effects of functional electrical stimulation (fes) on physical performance and quality of life of patients in cardiac rehabilitation.

this randomized controlled trial aimed to evaluate the effects of functional electrical stimulation (fes) in patients with stage ii and iii cardiac rehabilitation (cr) on the variables strength, endurance and muscle tropism lower limb, functional capacity and quality of life. to this were invited to participate in the study cardiac patients registered in the database of the cardiology department of the university hospital of santa maria. the sample included patients of both sexes undergoing coronary artery bypass grafting or valve replacement. the subjects were divided into two groups: placebo group (pg) or functional electrical stimulation group (fesg). to verify the effect of this intervention, before and after the protocol patients underwent the following evaluations: one repetition maximum test, sit-and-stand test, perimetry thighs, the six-minute walk test and evaluate the quality of life through the medical questionnaire study 36-item short-form health survey (sf-36).

Eligibility criteria:
inclusion criteria: * patients in phase ii and iii of cardiac rehabilitation undergoing coronary artery bypass grafting or valve replacement exclusion criteria: * patients with some cognitive impairment that prevents the completion of assessments, inability to understand the term of free and informed consent or with the following contraindications to the use of fes: epidermal lesions at the site of application, change of skin sensitivity or intolerance electrical stimulator; * patients undergoing cardiac surgery other than coronary artery bypass grafting or valve replacement; * patients who use pacemakers; * subjects with peripheral vascular changes in the lower limbs; * presence of comorbidities such as chronic obstructive pulmonary disease (copd), cerebrovascular disease or skeletal muscle disease.

Keywords: thoracic surgery electrical stimulation rehabilitation quality of life
cccg-alcl-2020 for chinese children and adolescents with newly diagnosed high-risk alcl

Conditions: Pediatric Anaplastic Large Cell Lymphoma

Summary: a prospective study on the efficacy of modified alcl99 regimens in the treatment of the current chinese pediatric and adolescent high-risk alcl and compared with our historical data.

anaplastic large cell lymphoma (alcl) accounts for 15% of pediatric and adolescent non-hodgkin lymphomas (nhls). in our historical study (retrospective multicenter study), the 3-year event-free survival (efs) was 65% for 80 eligible patients treated in 10 centers between january 2009 and june 2014. the alcl99 trial reported a 2-year overall survival of 92% and 2-year event-free survival of 74% then become the current standard frontline treatment for pediatric alcl. the recent long-term follow-up data from alcl99 trial highlighted its excellent outcome. a less toxic schedule of methotrexate (mtx) 3g/m2 in a 3-hour infusion without intrathecal therapy reproduced the favorable results from previous reports of nhl-bfm90 protocol with mtx at 1g/m2 in a 3-hour infusion. additionally, a prospective alcl-relapse trial by the european inter-group for childhood non-hodgkin lymphoma demonstrated 80% of patients with a late relapse can be cured by 24 months of vinblastine monotherapy. however, vinblastine would not be advised as a treatment option in mainland china due to its inaccessibility. a pilot experience using single-drug vinorelbine in 4 pediatric patients with relapsed alcl with satisfactory outcome provides the rational for studying vinorelbine as a front line drug option.

Eligibility criteria:
inclusion criteria: * patient must be ≤ 18 years at the time of diagnosis * newly diagnosed patients with histologically confirmed high-risk anaplastic large cell lymphoma * no congenital immunodeficiency, hiv infection, or prior organ transplant exclusion criteria: * patients have received prior cytotoxic chemotherapy/target therapy/radiation, if any steroid applied, total prior steroids dosage \> dexamethasone 40 mg/m2 for the current diagnosis or any cancer * patients have overwhelming infection, and a life expectancy of \< 2 weeks

Keywords: anapestic large cell lymphoma vinorelbine pediatric treatment outcome chinese