Kornimate/medical-research-clean huggingface dataset:
measuring the effects of therapeutic education program "caratif" patient under strong opioids versus standard taking charge of patient pain receiving opioid therapy in medical oncology.

Conditions: Pain Management

Summary: a first empirical evidence on the difficulties of observance of morphine in cancer patients invited a multidisciplinary team to initiate an innovative quality approach. it shows the lack of transcript of a comprehensive care causing a problem for monitoring actions undertaken for the relief of pain. in addition, two exploratory studies targeting the expectations and needs of the patient therapeutic education (e.t.p) receiving strong opioids. the e.t.p, public health priority, provides a framework for action and improving care. in oncology, the involvement of the patient in pain relief and management of opioids represents an axis of intervention more appropriate. yet, it is not found in literature. in our department, we conduct an experimental therapeutic education program type "caratif" and a nurse consultation fte receiving opioids on the model of nursing "care" of j. watson (humanist emphasis promoting interpersonal teaching-learning mobilizing the patient experience). the etp folder and its tools have been continuously validated with patients. the heart of the educational process is in the patient's complex path neat oncology and relies on interaction and creativity between patient and caregivers.


Eligibility criteria:
inclusion criteria: * adult * cancer patients receiving opioids * suffering from pain caused by their disease or treatment with chemotherapy and / or radiotherapy and / or surgery * supported within the oncology or palliative care * receiving at least 3 courses of chemotherapy * having read, understood and signed the informed consent * subject beneficiary of a social security scheme or an equivalent - exclusion criteria: * adults subject to a legal protection measure or unable to consent * non-beneficiaries of a social security scheme, * persons deprived of liberty by a judicial or administrative decision, * patients with neurological or psychiatric disorders

Keywords: opioid therapy medical oncology.
arc in hemorrhagic stroke

Conditions: Hemorrhagic Stroke; Augmented Renal Clearance

Summary: to determine the incidence and predictors of augmented renal clearance (arc) in patients with hemorrhagic stroke.


Eligibility criteria:
inclusion criteria: * adults ≥ 18 years * patients with hemorrhagic stroke * anticipated length of stay in the neuroscience intensive care unit \> 48 hours * informed consent provided by the patient or by the patient's designated medical proxy exclusion criteria: * pregnancy * patients with pre-existing renal dysfunction (chronic kidney disease stages 3 - 5) * patients receiving renal replacement therapy * patients with an admission serum creatinine \> 1.4 mg/dl * patients with non-aneurysmal subarachnoid hemorrhage * patients with history of nephrectomy or body mass index \< 18 kg/m2
the effects of mouthguard and desensitizing toothpaste in reducing dental hypersensitivity

Conditions: Dentine Hypersensitivity; Tooth Erosion

Summary: tooth hypersensitivity due to dental erosion is one of the most common problem related to swimming in improper ph chlorinated pools. because the teeth are exposed to acidic water for a long time, which cause the loss of dental hard tissue. tooth hypersensitivity can lead to a negative effect on daily life such as dietary selection, maintaining optimal dental hygiene and beauty aspects. it has been found that using mouthguard while swimming can prevent the teeth directly contact to chlorinated water, so it can protect tooth structure and decrease tooth hypersensitivity. moreover, using mouthguard with viscous products can seal the gaps between mouthguard and teeth which can help to protect tooth structure and decrease dental hypersensitivity more effectively. at present, there are many desensitizing products such as toothpaste, mouthwash and chewing gum. desensitizing toothpaste is the most common over-the-counter (otc) materials in desensitizing. many research has endorsed the properties of desensitizing toothpaste that can reduce tooth tissue loss and helps to reduce tooth hypersensitivity effectively. so it can be hypothesize that when use the combination of mouthguard with desensitizing toothpaste, it might have synergistic effect on reducing tooth hypersensitivity in swimmers.

tooth erosion is the loss of dental hard tissue due to acidic agents without bacteria involvement. mouthguard is a protective appliance use for covering the teeth and gums to prevent the teeth from acidic chlorinated water. desensitizing toothpaste is toothpaste containing 8 percent arginine and calcium carbonate that can reduce tooth demineralization and promote remineralization.

Eligibility criteria:
inclusion criteria: * age 13-25 years (age under 18 years must obtain consent from parents) * swimming at least 5 hours/week * having tooth hypersensitivity from erosion * can read or understand thai language exclusion criteria: * history of allergic to toothpaste * having any tooth which will affect to the tightness of mouthguard * having fixed orthodontic appliance

Keywords: dentine hypersensitivity toothpaste tooth erosion
pet assessment of acute lung transplant rejection

Conditions: Lung Disease

Summary: the purpose of this research study is to gain understanding of the basic responses of the lungs to inflammation and specifically if there may be a better way to detect graft inflammation using non-invasive methods as well as to determine the effectiveness of immunosuppressive treatment regimens in preventing acute rejection in lung transplant recipients.

positron emission tomography with fluorodeoxyglucose (fdg-pet) is a potential way we can measure lung inflammation. fdg-pet imaging is a clinically accepted and fda-approved method that is commonly used in the diagnosis and management of cancer. pet is a machine that detects radiation and generates pictures using a donut shaped scanner similar in appearance to an x-ray "cat" computerized axial tomography or computed tomography (ct) scan. fdg stands for \[18f\] (flourine 18) fluorodeoxyglucose, a radiolabeled sugar that is used to identify areas of inflammation with the pet scanner. a ct scan takes a picture of what the lungs and airways look like. t cells are the primary cause of acute rejection of lung transplants. because t cells must divide in order to be activated and cause rejection, imaging them while they are dividing is another way that we can determine whether acute rejection is occurring. a new pet tracer called \[18f\]iso-1 (18f-labeled σ2-receptor ligand for pet, n-(4-(6,7-dimethoxy-3,-4-dihydroisoquinolin-2(1h)-yl)butyl)-2-(2-18f-fluoroethoxy)-5-methylbenzamide (18f-3c), binds to dividing cells. therefore, \[18f\]iso-1 may help us measure acute rejection more accurately. \[18f\]iso-1 is an investigational drug.

Eligibility criteria:
inclusion criteria: * double-lung transplant recipient * scheduled for bronchoscopy with transbronchial biopsy * capable of lying still and supine with arms raised above the head within the pet/ct scanner for \~1.25 hours * capable of following instructions for breathing protocol during ct portion of pet/ct * able and willing to give informed consent * bmi \< 35 * already scheduled to undergo bronchoscopy with bronchoalveolar lavage (bal) for clinical reasons * willing to donate a portion of bal and biopsy specimen for laboratory testing exclusion criteria: * glucose level \> 150 mg/dl at time of \[18f\]fdg pet scan (however, up to 160 mg/dl, with repeat testing showing level is stable or decreasing, is acceptable) * pregnancy (confirmed by qualitative urine human chorionic gonadotropin (hcg) pregnancy test) * lactation * presence of implanted electronic medical device * enrollment in another research study of an investigational drug * inability to lie flat with arms raised above the head for 1.5 hours for pet/ct scans or follow breathing protocol instructions for the ct portion of the pet/ct

Keywords: acute lung transplant rejection neutrophilic lung inflammation positron emission tomography imaging [18f] fluorodeoxyglucose [18f] iso-1
the cloqs trial - countdown lights to optimize quality in stroke

Conditions: Acute Stroke

Summary: to reduce door-to-needle times in acute stroke treatment. using an organizational behaviour intervention (a large stopwatch), we will post a visual cue to remind all parties that "time is brain". we hypothesize that this simple visual cue will improve door-to-ct scan times and door-to-needle treatment times, and thus improve treatment response, and reduce adverse events.

we will construct a large, "in-your-face" red led stopwatch-clock that is the intervention. the clock will be attached to the stretcher of patients presenting for hyperacute stroke treatment (consideration of tissue plasminogen activator (tpa) treatment at the moment of their emergency department arrival. this will act as a constant visual reminder to all team members (physicians, rn's, ct technologists) of the urgency of the situation. the study will be a block randomization, by week of presentation. all patients presenting during "on" weeks will have a stopwatch timer with them during the hyperacute stroke workup. during "off" weeks, the clocks will not be used.

Eligibility criteria:
inclusion criteria: * all patients who present to the emergency room with acute stroke for consideration of treatment with tpa. exclusion criteria: * patients presenting to the emergency room (door time) more than 4.5 hours after symptom onset

Keywords: acute stroke emergency departments quality improvement improved processes tpa door-to-needle door-to-treatment
tdf and entekavir - hepatitis b reactivation

Conditions: Hepatitis B Reactivation

Summary: this is a non-interventional retrospective multi-center study for the patients received entekavir or tdf for hepatitis b prophylaxis.


Eligibility criteria:
inclusion criteria: * patients used entekavir or tdf for hepatitis b prophylaxis exclusion criteria: * patients lower then 18 years old.
effects of exercıse on chronotype, sleep qualıty and depressıon symptom level in unıversıty students

Conditions: Depression, Anxiety; Chronotype; Physical Activity

Summary: the aimed this study is to determine the effect of regular exercise program on mood, chronotype and sleep quality in university students.

the study is a quasi-experimental study with a pretest-posttest design. demographic information (age, gender, height, weight, education, marital status, occupation, where and with whom they live), additional diseases, medications used, whether they live in a rural or urban area, whether they have had any previous sleep problems, and whether they have had any previous psychiatric diagnoses will be recorded for all subjects in the study. before the exercise, students will fill out the pittsburgh sleep quality index to determine their sleep quality, the morningness-eveningness scale to assess their chronotype, and the beck depression inventory to measure their depressive symptom levels, and the results will be recorded. all exercises performed by the students for 8 weeks will be monitored by the researcher physiotherapist through weekly short individual or group interviews with the students. at the end of the eighth week, students will fill out the pittsburgh sleep quality index, morningness-eveningness scale, and the beck depression inventory again, and the results will be recorded.

Eligibility criteria:
inclusion criteria: * studying at aydın adnan menderes university söke health services college, * taking the body mechanics course, * being between the ages of 18-49, * being able to read, speak and understand turkish. exclusion criteria: * having received physical therapy services due to musculoskeletal diseases in the last 3 months, * having musculoskeletal diseases such as ankylosing spondylitis, chronic or structural joint diseases, * having congenital malpositions of the musculoskeletal system, * having a physical disability, * having undergone artificial joint replacement, * having multiple sclerosis, myodystrophic or other neurodegenerative diseases, having serious diseases such as acute herniated disc, using muscle relaxants or other drugs that affect muscle elasticity, having a cardiovascular disease, having a history of previous back surgery, having a traffic accident in the last 6 months, not being within the age range determined for the study, having a mental disability that prevents answering the comprehension and evaluation forms.

Keywords: physical activity depression chronotype
tandemheart experiences and methods (theme registry)

Conditions: Heart Diseases; Lung Diseases

Summary: this study is intended to be a multicenter, prospective observation registry. by collecting prospective descriptive data, provide insight into disease defining characteristics resulting in the clinical decision to use tandemheart® or lifesparc™ system for mechanical support and enhance knowledge of best practice regarding clinical management, weaning and removal/exit strategies.

the tandemheart or lifesparc percutaneous extracorporeal life support system is used to support circulation. the percutaneous cannulas facilitate access to the venous and arterial circulatory vessels. when connected to the tandemheart or lifesparc centrifugal pump, mechanical support is provided with sufficient cardiac power to perfuse the organs of the body. it is anticipated that theme registry™ analysis will provide insight into disease defining characteristics resulting in the clinical decision to use the tandemheart or lifesparc system for mechanical support and enhance knowledge of best practice regarding clinical management, weaning and removal. the progression of the illness prior to, during and following support will be collected. the theme registry will collect descriptive data regarding patient selection criteria and the clinical management of the patient including strategies used to wean and remove the device. specifically the objectives of the theme registry are: * summarize the characteristics of the patients who receive the system for temporary percutaneous mechanical support with or without an oxygenator, including demographics, pre-implant medical history, details of present illness, exit strategy. * evaluate the timing of initiation of system support in relation to the progression of the presenting illness and the association of this with clinical outcomes. * collect descriptive data related to clinical management of the patient while on mechanical support, including procedural details, duration of support, anticoagulation, hemodynamics and biochemical parameters to define trends in clinical care and the association of this decision-making with clinical outcomes. * collect hospital discharge information including intensive care unit (icu) and hospital length of stay (los). * collect survival and exit strategy status at 30 and 180 days post-initial system insertion. * collect serious adverse events from the time of pump insertion through removal of the system (or pump). * provide data regarding patient characteristics and outcomes.

Eligibility criteria:
inclusion criteria: 1. patient has had the tandemheart or lifesparc system inserted percutaneously (e.g. in the cath lab or peri-operatively) 2. age \>= 18 3. patient (or legally authorized representative \[lar\]) has signed informed consent exclusion criteria: 1. patient is incarcerated (prisoner) 2. participation in a clinical trial of an investigational drug or device

Keywords: circulatory support extracorporeal circulatory support extracorporeal bypass lifesparc
screening for breast cancer with digital breast tomosynthesis

Conditions: Breast Cancer

Summary: randomized trial comparing the performance of tomosynthesis and 2d digital mammography vs 2d digital mammography only in respect to incidence of advanced cancers (interval and following round) and interval cancers.

the investigators conduct a randomized trial (about 20000 tests in the intervention arm) comparing the performance of tomosynthesis plus 2d digital mammography vs usual care (2d digital mammography) in respect to incidence of advanced cancers (interval and following round) and interval cancers. the investigators also will measure detection rates, specificity, interval cancers, advanced cancers occurring as interval cancers or at subsequent screens and allowing to estimate overdiagnosis. in reggio emilia a population-based screening program is active. it invites all women from 45 to 74 years old for a 2d digital mammography (2 projections, double reading) every 2 years (annually from 45 to 49). women will be asked for informed consent when they attend the mammography. i they accept they will be randomised to one of the two arms. all examinations will be read by two independent radiologists, in case of discordance a third reading is asked.

Eligibility criteria:
inclusion criteria: 45-70 years old women invited to breast cancer screening program who accepted to participate exclusion criteria: * previous breast cancer diagnosis * pregnancy or suspicion of pregnancy * presence of brca1/2 gene mutation * previous digital breast tomosynthesis performed * unable to understand informed consent * chemotherapy in progress * presence of breast implant

Keywords: tomosynthesis,sensitivity,specificity,screening,mammography
the zeaxanthin and visual function study

Conditions: Age Related Macular Degeneration; Cognition Disorders

Summary: to evaluate if supplementation of zeaxanthin (with or without lutein) is beneficial to patients with early and moderate atrophic age related macular degeneration.

to evaluate whether or not zeaxanthin supplementation raises macular pigment optical density (mpod). previous research has shown mpod to mirror visual benefits for patients with age related atrophic macular degeneration (amd) having visual symptoms (decreased visual acuity, contrast sensitivity, photostress glare recovery and national eye institute visual function questionnaire 25 scores), but lower risk national eye institute (nei) / age related eye disease study (areds) characteristics.

Eligibility criteria:
inclusion criteria: * diagnosis of atrophic amd (icd9 362.51) by stereo bio-ophthalmoscopy and at least one vision degrading visual-psychophysical abnormality associated with amd in one or both eyes. * clear non-lenticular ocular media (cornea, aqueous and vitreous) * free of advanced glaucoma and diabetes or any other ocular or systemic disease that could affect central or parafoveal macula visual function exclusion criteria: * high risk retinal characteristics for advanced amd or advanced amd for which existing medical / surgical options are available * presence of ophthalmologically significant active exudative, amd pathology by fluorescein angiography but also a single large drusen, \>15, multiple intermediate drusen, parafoveal geographic atrophy or loss of vision in one eye due to advanced amd * recent (within 6 months) cataract or retinal surgery * taking photosensitizing drugs such as phenothiazines and chloroquine * having taken lutein or zeaxanthin supplements within the past six months.

Keywords: macular pigment optical density skin carotenoids lipofuscin photostress (glare recovery) visual field progression contrast sensitivity color vision cognitive function
effects of non-invasive brain stimulation in impulse control disorders

Conditions: Impulse Control Disorder

Summary: the goal of this project is to study the effect of noninvasive brain stimulation on decision-making and on brain activity in impulse control disorders.


Eligibility criteria:
inclusion criteria: * impulse control disorders according to dsm-iv criteria exclusion criteria: * other psychiatric disorders * contraindication to non-invasive brain stimulation and mri
neonatal pulse oximetry sensor study

Conditions: Premature Birth

Summary: to validate the spo2 accuracy, bias, and precision of medline's reprocessed pulse oximetry sensors as compared to sao2 in arterial blood samples as assessed by co-oximetry in neonates.

pulse oximetry helps in measuring peripheral capillary oxygen saturation (spo2) continuously and non-invasively, and provides an indirect measurement of arterial oxygenation (sao2) based on the red and infrared light-absorption characteristics of oxygenated and deoxygenated hemoglobin. uses of pulse oximetry include detection of hypoxia, avoidance of hyperoxia, titration of fractional inspired oxygen, and enabling weaning from mechanical ventilation. arterial blood gas (abg) analysis, such as by the use of co-oximeter, provides a direct measurement of sao2. however, abg analysis requires time, expense, and arterial access. therefore, this study aims to validate the spo2 accuracy of pulse oximetry sensors (manufactured by nellcor and masimo, and reprocessed by medline industries, lp) in neonates as compared to abg measurements as part of their clinical standard of care (soc), as assessed by co-oximetry.

Eligibility criteria:
inclusion criteria: * subjects who are postnatal 28 days or younger (neonates) * subjects who are likely to receive one or more abg measurements as part of their clinical soc * subjects who weigh less than 5 kg (weight range for thesensors) exclusion criteria: * subjects with current signs and symptoms of a clinically significant patent ductus arteriosus (pda) combined with a current or planned arterial line placement which will affect the validity of the co-oximetry measurement * subjects with physical malformation of hands, fingers, feet, or toes that would limit the ability to place sensors for this study * subjects judged by the principal investigator (pi) to be inappropriate for participation in this study * subjects for whom placing a pulse oximeter will cause dermatological issues (e.g. allergic to foam rubber or adhesive tape)
madany closure: a novel technique for fascial closure in laparoscopic surgery

Conditions: Cholecystolithiasis

Summary: this study aims to evaluate the effectiveness of the use of a basic laparoscopic instrument (only needle holder) with a new technique for port site closure


Eligibility criteria:
inclusion criteria: * age . 18 years * eligible for laparoscopic cholecystectomy exclusion criteria: * refused to participate