Kornimate/medical-research-clean huggingface dataset:
fpam for the in vivo depth measurement of pigmented lesions and melanoma depth

Conditions: Pigmented Skin Lesion; Melanoma

Summary: the investigators propose the use of functional photoacoustic microscopy (fpam) to evaluate both benign and malignant pigmented lesions for tumor depth. through fpam analysis followed by histological examination, the investigators anticipate that they will be able to non-invasively determine tumor depth of pigmented lesions (moles and melanoma). in melanoma, tumor depth (breslow's depth) is not only an important prognostic indicator, but also directs surgical treatment. the ultimate goal is to develop a sensitive clinical tool that will allow non-surgical evaluation of pigmented lesions, which eventually, will aid in melanoma diagnosis and management - potentially an earlier and more definitive surgical management. in addition, the investigators propose to use the combination of fpam and single-cell pam to respectively image ctcs in trunk vessels and cuticle capillaries. based on the investigators' murine models, the investigators anticipate that they will be able to differentiate ctcs from other blood cells and reliably calculate ctc concentration in a non-invasive manner. ctc concentration has been demonstrated to be a valuable indicator of a melanoma's metastatic potential and a potential tool in evaluating treatment efficacy. the ultimate goal is to develop a sensitive imaging device that will allow accurate evaluation of the risk of melanoma recurrence and metastases, that may facilitate treatment monitoring.


Eligibility criteria:
inclusion criteria: outcome measure #1 and #2 * healthy individuals with pigmented lesions or a partially biopsied melanoma whose treatment plan includes excision * participants must be 18 years or older * participants must be able to understand and willing to sign a written informed consent document outcome measures #3 and #4 * patients with either cutaneous, visceral or brain melanoma metastases. * participants must be 18 years or older. * participants must be eastern cooperative oncology group (ecog) status 0-3. * participants must be able to understand and willing to sign a written informed consent document. exclusion criteria: * minors, pregnant patients, incarcerated individuals, and individuals unable to give informed consent will be excluded from this study * ecog status \> 3

Keywords: melanoma imaging pigmented lesions melanoma management
mesenchymal stem cells; donor and role in management and reconstruction of nonunion fracture

Conditions: Healing of Fracture

Summary: the investigators hypothesized that mesenchymal stem cells can be isolated from fracture site, iliac crest, and tibial crest, and can be expanded to be used in the management of nonunion fracture.


Eligibility criteria:
inclusion criteria: * athropic nonunion fracture of the long bone exclusion criteria: * immunocompromise, * active infection, * pathological fracture, * ongoing hormonal therapy

Keywords: nonunion stem cells autograft hydroxyapatite
genesis of scleroderma: role of environmental factors in 100 patients with scleroderma and 300 controls

Conditions: Scleroderma

Summary: scleroderma is an autoimmune disease of unknown origin. recently, the role of environmental factors, and particularly toxic drug exposure, in the genesis of scleroderma has been suggested. this prompted us to conduct this prospective, case-control, multicentric study, including 2 groups of subjects: * 100 patients with scleroderma * 300 sex- and age-matched healthy controls. the aim of our study is to determine whether exposure to toxics is higher in patients with scleroderma compared with healthy controls.

the data of patients with scleroderma and healthy controls will be compared regarding: * a standardized questionnaire about "cursus laboris" at initial inclusion * a search for toxics in blood, urine and hair: at initial exvaluation, 6 month and 2 year-follow-up

Eligibility criteria:
inclusion criteria: * patients with scleroderma with: * age range : 18 to 76 years * written consent exclusion criteria: * patients with other connective-tissue disorders * pregnant women * patients with psychiatric conditions * unwritten consent
evaluation of extracorporeal shockwave therapy and complex decongestive therapy results in patients with lipedema

Conditions: Lipedema; Pain

Summary: the aim of the study is to evaluate the results of the extracorporeal shockwave therapy and complex decongestive therapy in patient diagnosed with lipedema.

the collected content will be transferred over spss 21.0. the normality distribution of the data will be evaluated with the shapiro-wilk test. data will be displayed as mean±standard deviation, median (1st quartile-3 quartile), or number(percent). in comparisons between the two consuming variables before and after exercise, if the values fit the normal distribution, the "paires sample t test" is used, if not, the wilcoxon test is used. in the comparison of 3 groups, one-way anova will be applied if it is normally distributed, and if it does not fit the normal distribution, the kruskal wallis test will be applied. post-hoc analysis was planned for the printer, which was determined to determine the method statistically. to compare categorical protections is to use the chi-square test. p \< 0.05 will be considered future.

Eligibility criteria:
inclusion criteria: * female * 18 years or older * being diagnosed with lipedema according to wold criteria * having type 1, 2 and 3 lipedema * having stage 1, 2 and 3 lipedema exclusion criteria: * known rheumatic, endocrinological, neuromuscular, dermatological disease, kidney failure, liver failure and malignancy * having undergone surgery for lipedema * having poor circulation, open wound or infection in the lower extremities

Keywords: lipedema complex decongestive therapy extracorporeal shockwave therapy
phase 3 study of acupression's bracelets in nausea and vomiting induced by fec100 chemotherapy's sort.

Conditions: Breast Neoplasms

Summary: the purpose of this study is to demonstrate a betterment of the digestive symptomatology by the anti-emetic acupression's bracelets's use associated with hygiene and dietetic advices.


Eligibility criteria:
inclusion criteria: * woman * age \> 18 years * well-informed written consent, signed by the patient before the beginning of the study * breast cancer's diagnosis (operated or not) * forecast of a treatment by fec100 chemotherapy's sort (d1=d21) during at least 3 cycles. * patient affiliated at a welfare or beneficiary from it * investigator estimates that the patient is able to conform with protocol's conditions and to respect them exclusion criteria: * operated arm's lymphedema * wrist's morphology which cannot permit the bracelet's wearing (20 cm) * d1=d15 fec100's treatment * psychic incapability to sign a well-informed consent * refusal to give a written consent * patient under tutelage or guardianship * pregnant or breast-feeding woman * any clinical trial's participation which would impose nausea and vomiting's treatment modalities

Keywords: breast neoplasm fec100 chemotherapy acupression bracelet nausea vomiting
nasal high frequency oscillatory versus nasal intermittent positive pressure ventilation in neonate after extubation

Conditions: Respiratory Insufficiency

Summary: to evaluate the efficacy and safety of nasal high frequency oscillatory ventilation(nhfov) in preterms with respiratory disease syndrome(rds) after extubation.

to very low birth weight infant(vlbw) with respiratory disease syndrome(rds) who need mechanical ventilation,early extubation may have more benefits.early extubation may decrease the ventilation-associated pneumonia(vap),sepsis and decrease the incidence of severity bronchopulmonary dysplasia(bpd).but often fail attempts at extubation because of apnea,atelectasis,hypercapnia,hypoventilation or other illnesses. high frequency oscillatory ventilation is benefit to lung.initial ventilation with hfov in preterm with rds may reduce the incidence of bpd and improve the neurodevelopment.compared hfov with conventional ventilation in preterm infants showed that hfov had superior lung function when 11 to 14 years age.whether nasal high frequency oscillatory ventilation(nhfov) also have those advantages in non-invasive mode? null d m et al do a experiment on preterm lambs,the result suggest that nhfov may promotes alveolarization.but there was no clinical trials to prove. the nasal intermittent positive pressure ventilation (nippv) group fail definition：1、 fraction of inspired oxygen (fio2)\>40%、map\>12 centimeter water column (cm h2o),but arterial oxygen saturation (sao2)\ 60millimeter of mercury(mmhg)or partial pressure of arterial oxygen (pao2)\ 6 episodes requiring stimulation in 6 hours or requiring \>1 episodes of positive-pressure ventilation) 5.potential of hydrogen (ph)\<7.2 the the nhfov group fail definition：1、fio2\>40%、map\>14 mbar,but sao2\ 60millimeter of mercury(mmhg) or pao2\<45millimeter of mercury(mmhg).4、severe apnea 5.ph\<7.2.

Eligibility criteria:
inclusion criteria: 1. birth weight\>1000g 2. gestational age \>28 weeks 3. have respiratory distress syndrome and need invasive ventilation exclusion criteria: 1. birth wight\<1000g 2. gestational age \<28 weeks 3. infants wiht abnormalities of upper and lower airways 4. infants have contraindications of non-invasive ventilation -

Keywords: very low birth weight respiratory distress nhfov nippv
comparative study of minimally invasive surgical approaches for total hip arthroplasty

Conditions: Hip Osteoarthritis; Hip Arthropathy; Minimal Invasive; Anterior Approach; Tissue Injury

Summary: total hip arthroplasty is a method of choice for treating advanced osteoarthritis of the hip and one of the most frequent orthopedic procedures. of all hip surgical approaches described, the tendency for minimally invasive techniques has been dominated over the last few years due to faster patient mobilization, reduced postoperative pain and need for blood transfusion. two of the most common approaches used for minimally invasive total hip arthroplasty are: amis anterior approach and mini-posterior approach, which is a modification of the standard posterior approach. the purpose of this study is the biochemical, imaging and clinical evaluation of the tissue damage caused by the above-mentioned techniques of minimally invasive total hip arthroplasty.


Eligibility criteria:
inclusion criteria: * patients that sign the informed consent * patients aged 18 years and over who are going to undergo primary total hip arthroplasty exclusion criteria: i. active infection ii. previous hip operation in any leg iii. any kind of operation the past 3 months iv. obesity (bmi, body mass index \>30) v. autoimmune diseases or myositis of any etiology vi. active cancer
gene expression analysis of the endometrium after endometrial biopsy in fertile women

Conditions: Infertility

Summary: the aim of this study is to evaluate the gene expression of the endometrium after an endometrial biopsy in fertile women using next generation sequencing of total rna.

an endometrial biopsy is done at cycle day lh+7 and repeated in the next cycle at cycle day lh+7. tissue is analysed and compared for changes in gene expression profile using seq rna

Eligibility criteria:
inclusion criteria: * fertile women * age: 18-40 years * bmi: 18-32 * regular menstrual cycle * no use of hormonal contraceptives or iud the last 3 months exclusion criteria: * patients in need of a interpreter * suspected intrauterine abnormalities * pregnancy

Keywords: infertility endometrium endometrial biopsy gene expression
psoas density in colorectal cancer

Conditions: Cancer of Colon

Summary: colorectal cancer (crc) is the 3rd most common cancer worldwide. in the uk, crc is the 4th most common cancer accounting for 12% of cancers diagnosed each year with approximately 41,300 new cases diagnosed in 2014. surgery remains the only treatment option that can reliably achieve cure from colorectal cancer and thus nearly 20,000 major bowel resections are performed for this yearly in the uk. surgery for these cancers however carries risk of major complications and potentially death. selecting appropriate patients for surgery remains a challenge to cancer teams. risk factors exist for complications after surgery for crc, many of which can be assessed and discussed with the patient prior to surgery, so that any decision to operate is with fully informed consent from the patient. increasing attention is being paid to a patient's frailty or fitness as one of these risk factors. our centre has previously shown that measuring the cross-sectional area of the psoas muscle (a large muscle near the spine) from preoperative imaging could predict major complications in colorectal cancer patients (jones 2015), however specialist software and patient height is required to make this calculation. more recently we have demonstrated that the measurement of the psoas muscle density on preoperative imaging (i.e. routine ct scans that all patients have before surgery to plan treatment), may potentially be useful to predict which patients are at most risk of a major complication (herrod 2019). if this finding holds true when tested on a larger scale, it could be used to help surgical teams make the decision on whether to offer surgical resection, what kind of operations to perform, how to best support individuals undergoing operation and to ensure that the patient has the most information available to decide what risk they are at by having major surgery.


Eligibility criteria:
inclusion criteria: patient criteria: * having a major colorectal resection for the treatment of cancer * elective or emergency surgery * adults, defined as age ≥18 years of age (no maximum limit) * had a preoperative ct scan of the abdomen with contrast (portal venous phase) * operation performed between 31st aug 2013 - 31st aug 2019 exclusion criteria: * not having a preoperative ct scan with contrast

Keywords: psoas muscle density frailty
comparison of craniosacral therapy and myofacial relaxation techniques in people diagnosed with migraine

Conditions: Migraine Disorders

Summary: headache is a neurological condition that is very common all over the world and is observed at some time in life in more than 90% of society. migraine headache, known for thousands of years, is one of the oldest diseases of humanity. the word 'hemicrania', meaning 'half of a head', is used due to unilateral pain. approaches to treating migraine include medication, relaxation, biofeedback, living a regular life, adequate sleep, exercise, and stress management. neck pain is especially common in migraine patients. exercise, manual practices, electrop novelties are used to reduce musculoskeletal problems, thus reducing the effects of migraine. myofascial relaxation techniques, which are included in the manipulative techniques in the literature, are relaxation methods performed on myofascial trigger points.osteopathic manual therapy (omt) , which has recently entered the literature, 19. osteopathy, developed by andrew taylor still at the end of the century, is a treatment system characterized by focusing on integrity and using it by hand to heal diseases.the study of cranial omm kraniyum first anatomical and physiological mechanisms for the prevention and treatment of disease as a whole is concerned with the relationship of the body, including diagnostic and therapeutic methods.it is used in the treatment of somatic dysfunction of the head and other body parts. an important component of cranial omm is the primary respiratory mechanism, which occurs as movement of the head bones, sacrum, dural membranes, central nervous system and cerebrospinal fluid. the primary respiratory mechanism is synchronous with the cranial rhythmic impulse, a 2-phase rhythmic cycle that represents a dynamic metabolic exchange with each stage of the body. this cycle is indicated as loops between 7 and 14 per minute.fascial mobilization therapy increases energy use in segments implemented by mechanical changes.accordingly, it helps to reduce the spasm of these layers extending fascially, to dissolve adhesions, and to increase the range of motion of the joint. h0: osteopathic manipulative therapy has no effect on migraine symptoms. h1: osteopathic manipulative therapy has an effect on migraine symptoms. h2: myofascial relaxation techniques have no effect on migraine symptoms. h3: methods of osteopathic manipulative therapy have an effect on migraine symptoms. h4: myofascial relaxation techniques and osteopathic manipulative treatment methods have no superiority over each other. h5: myofascial relaxation techniques and osteopathic manipulative treatment methods have superiority over each other.


Eligibility criteria:
inclusion criteria: age 18-65 diagnosed with chronic migraine patients who have recently been diagnosed with chronic migraine who have not taken any medications so far for migraines. exclusion criteria: those in the drug group had a decommissioning of drug use for 4 weeks suspicion or presence of pregnancy

Keywords: migraine, osteopathic maniulative treatment, myofascial release, physiotherapy
safety and efficacy study of pain shield device to treat subjects following laparoscopic-assisted abdominal surgery

Conditions: Wounds

Summary: the purpose of this study is to evaluate safety and efficacy of painshield device, based on ultrasound technology, for postoperative pain relief and wound healing following a laparoscopic-assisted abdominal surgery.


Eligibility criteria:
inclusion criteria: * subject's age ≥ 18 * subject is able, agrees and signs the informed consent form * subject requires laparoscopic-assisted abdominal surgery * incision size following the laparoscopy between 4-7 cm exclusion criteria: * epidural analgesia * iv pca * subject has any condition, which precludes compliance with study and/or device instructions * subject is currently participating in another clinical study.

Keywords: laparoscopic-assisted surgery abdominal pain relief wound healing low intensity ultrasound
mcg for localization of tachyarrhythmia's origin

Conditions: Tachyarrhythmia; Atrial Flutter; Paroxysmal Supraventricular Tachycardia; Atrial Tachycardia; Atrial Fibrillation; Premature Ventricular Contraction

Summary: this is an exploratory research aiming to accurately identify the site of origin of tachyarrhythmia using magnetocardiography (mcg), which will have guiding significance for early diagnosis, the formulation of treatment plans and preoperative positioning for radiofrequency ablation.


Eligibility criteria:
inclusion criteria: * age 18-79 years old; * those whose conditions are comparatively stable and who have been diagnosed by an attending physician （or physicians with higher qualifications） with paroxysmal supraventricular tachycardia, atrial tachycardia, atrial flutter, atrial fibrillation, or premature ventricular contractions, and who are capable of performing mcg and cardiac electrophysiologic examinations after evaluation. * signed informed consent. exclusion criteria: * those with known structural heart disease such as cardiomyopathy and valvular disease; * those with history of other cardiovascular diseases such as pulmonary embolism and aortic dissection; * those with connective tissue diseases (lupus erythematosus, rheumatoid arthritis, dermatomyositis, polyarteritis nodosa, etc.) combined with cardiac complications; * those with obvious abnormal thyroid function, severe anemia or other blood diseases and other diseases that obviously affect the circulating blood supply; * those with obese (bmi\>30kg/cm2) or underweight (bmi\<18kg/cm2); * those with malignant tumors; * professional athletes, pregnant or breastfeeding women, alcoholics; * those with acute diseases or critical illnesses in other systems, such as acute or severe respiratory diseases, abnormal liver function or renal function, etc.; * those with infectious diseases or communicable diseases; * those who are unable or fail to perform magnetocardiography due to claustrophobia, physical impairment, etc.; * unable to or fail to cooperate with the corresponding research requirements.
surgery with or without chemotherapy in treating patients with newly diagnosed or recurrent bladder cancer

Conditions: Bladder Cancer

Summary: rationale: transurethral resection is a less invasive type of surgery for bladder cancer and may have fewer side effects and improve recovery. drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. it is not yet known whether transurethral resection plus ad 32 is more effective than transurethral resection alone for bladder cancer. purpose: randomized phase iii trial to compare the effectiveness of transurethral resection surgery followed by ad 32 with that of transurethral resection alone in treating patients who have newly diagnosed or recurrent bladder cancer.

objectives: i. assess the efficacy of adjuvant ad 32 following complete transurethral resection versus transurethral resection alone in patients with newly diagnosed or recurrent superficial transitional cell carcinoma of the bladder. ii. assess the toxicity of ad 32 in these patients. outline: this is an open label, randomized, multicenter study. patients are randomized to receive surgery with ad 32 or surgery alone. arm i: patients undergo surgery to remove bladder tumors. ad 32 is administered by catheter into the bladder within 2-24 hours after surgery. patients must hold the ad 32 liquid in the bladder for 90 minutes. arm ii: patients undergo only surgery to remove bladder tumors. patients with t1 or tis disease may receive bcg therapy once weekly for 6 weeks, followed by 6 weeks of rest. patients are followed every 3 months for 2 years. projected accrual: this study will accrue approximately 300 patients.

Eligibility criteria:
disease characteristics: histologically diagnosed stage 0 (ta), stage i, or recurrent superficial transitional cell carcinoma of the bladder must have at least 2 papillary appearing bladder tumors by cystoscopic examination patients with recurrent disease must have no history of tis tumor patient characteristics: age: 18 and over performance status: swog 0-2 life expectancy: not specified hematopoietic: wbc greater than 4000/mm3 platelet count at least 100,000/mm3 hepatic: bilirubin no greater than 2 times upper limit of normal (uln) sgot no greater than 2 times uln renal: creatinine no greater than 2 times uln other: not pregnant or nursing fertile patients must use effective contraception prior concurrent therapy: biologic therapy: no concurrent biological response modifiers for bladder cancer chemotherapy: no prior or concurrent chemotherapy for bladder cancer no prior ad 32 therapy for bladder cancer endocrine therapy: not specified radiotherapy: no prior or concurrent radiotherapy surgery: at least 9 months since any complete transurethral resection of the bladder

Keywords: stage 0 bladder cancer stage i bladder cancer recurrent bladder cancer transitional cell carcinoma of the bladder