Kornimate/medical-research-clean huggingface dataset:
low back pain intensity and core muscle strength after different delivery modes

Conditions: Low Back Pain and Core Muscle

Summary: cesarean delivery (cd) may trigger an increase in low back pain (lbp) intensity and induce core muscle weakness. this study will assess the correlation between low back pain intensity and core muscle strength of transverse abdominis and lumbar multifidus among women who underwent cd and compare it with those who experienced vaginal delivery.

cesarean delivery (cd) is one of the most common surgical procedures in obstetrics, and it is also one of the oldest medical procedures. the rise in the rate of cesarean sections is one of the most striking hallmarks of modern obstetrics. in egypt, the prevalence of cd has increased dramatically over the last decade, with the most recent egypt demographic and health survey (edhs) reporting a rate of 52 percent, implying that cesarean sections may be overused or utilized for improper reasons. the two deep local core muscles are the transversus abdominis and the lumbar multifidus muscles. the definition of core muscle strength is the active ability of these muscles to not only produce but also, maintain stresses to provide stability for the spine through management of the intra-abdominal pressure. lbp prevalence in mothers undergoing cesarean delivery was higher compared to its counterpart in mothers undergoing vaginal delivery. the related mechanisms for lbp during the postpartum period following cesarean or vaginal deliveries may be overweight and obesity, postural adaptations, and stressful positions that mothers assume during either delivery or lactation.

Eligibility criteria:
inclusion criteria: 1. all women are either primiparous or multiparous. 2. their ages ranged from 18 to 35 years. 3. all participants had a body mass index (bmi) of not more than 29.5, and a waist-to-hip ratio of not more than 1. 4. participants were assessed between the 6th week to the 12th week postnatal. 5. all participants were able to continue all assessment procedures. 6. they were medically stable. exclusion criteria: 1. women who were below 18 years old or above 35 years old. 2. women who had a (bmi) above 29.5 or a waist-to-hip ratio above 1. 3. women who did not continue all assessment procedures. 4. women who had a past history of specific lbp as those who were diagnosed with spondylolisthesis, lumbar disc prolapse, or structural scoliosis.
the impact of lifestyle behaviors on in vitro fertilization (ivf) outcome

Conditions: Infertility

Summary: many women undergoing in vitro fertilization (ivf) ask their doctor if there are any behaviors they should avoid, or any behaviors they should emphasize during their ivf cycle. this study examines the effects of health habits surrounding exercise, smoking, alcohol, sleep, caffeine, herbal medications, acupuncture, and diet on pregnancy rates during ivf cycles. the purpose of this study is to determine if lifestyle behaviors have a significant impact on pregnancy rates during treatment with ivf. this is an observational study conducted at a private academically-affiliated infertility clinic and includes 118 women ages 44 and below scheduled to undergo ivf treatment. all subjects were asked to complete a health history survey at the time of enrollment and a daily survey during each day of their ivf cycle. the primary outcome is clinical pregnancy rate.


Eligibility criteria:
inclusion criteria: * female boston ivf infertility patient undergoing ivf treatment * age 18-44 years * able to read, understand and sign the informed consent in english * willing and able to comply with study requirements * must be well versed in using a personal computer and the internet and must have access to an internet-connected computer seven days per week

Keywords: ivf lifestyle habits
cardiovascular and inflammaging study

Conditions: Aging; Cardiovascular Diseases; Overweight or Obesity

Summary: evidence from previous studies supports a strong relationship between fruit and vegetable consumption and reduced cardiac risk. this could be mediated via improvements on blood pressure, platelet function and vascular reactivity. certain vitamins and polyphenols found in fruits and vegetables, have antioxidant and anti-inflammatory effects and play a major role on the function of immune cells. previous studies have also demonstrated the importance of omega-3 fatty acids on humans' health and their positive effects on the cardiovascular system and blood lipids regulation, as well as their involvement on inflammatory response. nutritional regimens with adequate intake of micronutrients, fruit and vegetables, omega-3 fatty acids, low in sugar and saturated fats, such as the mediterranean diet or vegetarian diets, can reduce chronic inflammation and oxidative stress and improve cardiovascular risk profile. considering that the population's fruit and vegetable and omega-3 intakes are below recommendations, whole food-based supplements could provide an accessible form of supplementation to bridge the gap between actual and recommended intakes. this study is aiming to assess whether long-term separate ingestions of an encapsulated juice powder concentrate and a plant-based omega fatty acid supplement, or a combined ingestion of the two, can affect biomarkers of cardiovascular health, low-grade inflammation and indicators of biological aging in older adults.


Eligibility criteria:
inclusion criteria: * post menopausal * non-smokers * bmi 18.5 to 40 kg/m2 * vegetable intake ≤ 2 servings/ day * intake of fruits ≤ 2 servings /day * adherence to a 6-week washout period for dietary supplements not ingested for specific medical conditions. exclusion criteria: * age \ 80 years * smokers (or ex-smokers who quit smoking less than 3 years ago) * aversion to stop the intake of multivitamins, multiminerals or omega fatty acid supplements * subjects with histamine intolerance * hypertension, starting with grade 2 according to the classification of the european society of hypertension: systolic blood pressure \> 160mmhg, diastolic blood pressure \>100 mmhg * all medication taken for less than 3 months or with changes on the dosage over the last 3 months and medication for any of the conditions listed below. * clinically relevant infectious diseases * diabetes mellitus type i and type ii * rheumatic diseases * auto-immune diseases * any stents and coronary artery diseases (cad) * cancer patients * pregnancy * significant lifestyle changes, e.g. changes in diet or physical activity profile

Keywords: aging cvd prevention low-grade inflammation
hidradenitis suppurativa written action plan

Conditions: Hidradenitis Suppurativa

Summary: this study is being conducted to evaluate if a written action plan for hidradenitis suppurativa (hs) will help patients with hidradenitis suppurativa gain a better understanding of the condition and how to manage the condition on a daily basis compared to a routine verbal consultation.


Eligibility criteria:
inclusion criteria: * has a diagnosis of hs exclusion criteria: * has been exposed to a written action plan for hs before
interest of the intervention of a nurse coordinator in complex care pathway

Conditions: Hepatocellular Carcinoma

Summary: this project is based on the assumption that the nurse coordinators of the centres have common missions at each of the key stages of patient care. these missions make the care plan more fluid and improve the quality and safety of care as well as the patient's prognosis. the hypothesis is that co-follow-up by a doctor and a nurse coordinator reduces time between referral to treatment, average lengths of stay, unscheduled readmissions or early emergency visits, compared to follow-up that does not involve a nurse coordinator.

main objective: describe the roles and missions of professionals dedicated to the coordination of care pathways for patients with hcc secondary objectives: compare the indicators of quality of care in hcc centres with a nurse coordinator: 1. timeframe in treatment: * timeframe between the first contact with the hcc centre and the first interventional radiology treatment. * timeframe between the first contact with the centre and the first presentation at a multidisciplinary team meeting (mdt) * time between the first contact with the centre and the diagnostic consultation * timeframe between the first contact with the centre and discharge from the hospital * timeframe between the first interventional radiology procedure and the next for the subgroup of patients who have multiple procedures during the follow-up period * timeframe between the first contact with the nurse coordinator of the centre and discharge from the hospital. 2. the average length of stay of hospitalization 3. the number of visits to the emergency unit during the first month following the radiology intervention 4. the number of unscheduled readmissions during the first month following the intervention. assess the feasibility of collecting the above-mentioned timeframe and variables and the patients and carers feedback on the coordination of the care pathway describe the organization of care pathways for patients with hcc in centres with or without a nurse coordinator. research method: this is a retrospective descriptive pilot study. it aims to describe the organization of care. population: patient with a diagnosis of localized hepatocellular carcinoma. data processing: * feasibility questionnaires will be sent by email. * the interviews will be transcribed and coded with nvivo® software * patient data will be collected in the ecrf * data processing from anonymized files by the authors of the research only. all data will be centralized at bichat hospital (urc paris nord) for statistical analysis.

Eligibility criteria:
inclusion criteria: * centre with interventional radiology treatment * active list of patients followed for a hcc of at least 70 / year * reply to the feasibility questionnaire within 60 days from receipt of the email exclusion criteria: * patient with a localized hcc diagnosis (bclc a or b) * hospitalised for a first interventional radiology treatment (radioembolisation, transarterial chemoembolization or percutaneous ablation) in one of the centres included in the study between july 1, 2017 and december 31, 2017
rapp- systematic e-assessment of postoperative recovery in patients undergoing day surgery

Conditions: Postoperative Complications

Summary: introduction day surgery is a well-established practice in many european countries, but only limited information is available regarding postoperative recovery at home though there is a current lack of a standard procedure regarding postoperative follow-up. furthermore, there is also a need for improvement of modern technology in assessing patient related outcomes such as native software applications. this article describes the rapp study protocol, a mixed-methods study to evaluate if a systematic e-assessment follow-up in patients undergoing day surgery is cost effective and improves postoperative recovery, health and quality of life. methods and analysis this study is a mixed-methods study design that includes a multicenter, two-group, parallel, single-blind randomized controlled trial (rct) and qualitative interview studies. one thousand patients \>17 years of age who are undergoing day surgery will be randomly assigned to either e-assessed postoperative recovery follow-up daily in 14 days measured via smartphone app including the swedish web-version of quality of recovery (swqor) or to standard care (i.e. no follow up). the primary aim is cost effectiveness. secondary aims are improvements on postoperative recovery, health-related quality of life (qol) and overall health; (b) to determine whether differences in health literacy have a substantial and distinct effect on postoperative recovery, health, and qol; and (c) to describe day-care patient and staff experiences with a systematic e-assessment follow-up after day surgery.the primary will be measured at 2 weeks postoperatively and secondary outcomes b) at 1 and 2 weeks and c) at 1 and 4 months.


Eligibility criteria:
inclusion criteria: * understand the swedish language in speech and writing, have an android or iphone os smartphone, and give their informed consent to participate exclusion criteria: * undergoing abortion, if their journal entries indicate alcohol and/or drug abuse or memory impairment, if they are participating in another clinical trial or suffering from visual impairment. .

Keywords: smart phones ambulatory care outcome and process assessment
european registry on stemi patients transferred for pci with upstream use of abciximab - eurotransfer registry

Conditions: ST-Elevation Myocardial Infarction; Acute Coronary Syndrome

Summary: eurotransfer registry is a prospective, international, web-based european registry on patients with st-elevation mi transferred for mechanical reperfusion (pci) with a special focus on upstream use of abciximab. this registry is designed to collect data on approximately 1800 patients during a 12 month enrollment period in up to 20 interventional cardiology centres with hospital transfer networks from all over europe. analysis of this registry should allow to monitor transfer timelines of patients arriving to the cath-lab from the regional hospital with or without upstream start of abciximab and scheduled for mechanical reperfusion (pci) as well as to monitor regional differences across europe in regard to the impact that time of various stages of the treatment chain may have on clinical outcomes.


Eligibility criteria:
inclusion criteria: patients: * all consecutive stemi patients \>=18years arriving to the cath lab hospital (invasive facility center) from transfer. * transfer with respect to this registry is defined as patients that reach the cath lab hospital: 1. transferred from a surrounding regional community hospitals that the cath lab hospital has an established referral pattern with or 2. after being picked-up by an ambulance which is equipped/staffed to provide specific medical therapy (like prehospital thrombolysis or upstream abciximab). usually these have a physician or specifically trained nurse on board. centres: * provide 24 hour/7 days on duty pci service. * has an established regional hospital referral network with \>=8 patients/month arriving from transfer (as defined above). * a rate of \>=10% of these transfer patients who receive upstream abciximab before or during transfer to the cath lab hospital. start of abciximab in the er or ccu of the cath lab hospital will not be considered as upstream start of abciximab. exclusion criteria: * patients who arrive to the cath lab from other pathways than those specified above (a. and b.), e.g. those who come by ambulances that do not provide specific medical therapy or arrive directly to the er of the cath lab hospital by own feet/car will not be included in this registry. * patients from controlled clinical trials shall be included as long as their actual treatment is fully known. thus, participants from randomized trials with blinded treatment cannot be included in this registry.

Keywords: st-elevation myocardial infarction upstream abciximab guideline adherence hospital networking
compare aquacel® ag versus mepilex® border ag to manage bioburden in leg ulcers

Conditions: Leg Ulcers

Summary: the purpose of this study is to compare the ability of aquacel® ag and mepilex® border ag to manage bioburden in leg ulcers over a two week study period.


Eligibility criteria:
inclusion criteria: * aged 18 years or over * willing and able to provide written informed consent * leg ulcer will be of size ranging between 10 cm2 - 40 cm2 with moderate or heavy exudate * leg ulcer will exhibit at least 2 of the 4 following clinical signs: pain between 2 dressing changes, peri-ulcer skin erythema, oedema, foul odour exclusion criteria: * known skin sensitivity to any component of the products being tested * subjects who have had current local or systemic antibiotics and/or topical antimicrobials applied in the week prior to inclusion * depth of ulcer classified as superficial (not involving dermis) or deep (exposing muscle and tendon) * any other medical condition which, according to the investigator, justifies the subject's exclusion from the study * participated in a clinical study within the past 30 days
hair regrowth after bicoronal incision

Conditions: Alopecia

Summary: loss of hair growth potential in long surgical scalp incisions can become obvious to the patient and others, given hair's tendency to part along the resulting scar. bevelling incisions perpendicular to the hair follicle angle may increase hair growth through the scar. however, many factors may be confounders such as wound tension and cauterizing the incision. this study will investigate the effect a bevelled incision has on hair growth preservation compared to a standard incision that incises the skin perpendicular to its surface irrespective of hair follicle angles. following informed voluntary consent, subjects who require bi-coronal scalp incisions as part of a surgical plan will be enrolled. the right side of this bilateral incision will be randomized to receive either a bevelled or a standard incision and the left side will receive the opposite type. during routine surgical follow-up the hair growth within the scar of the two sides will be recorded for comparison and it is our hypothesis that the side with the bevelled incision will have more hair within the scar.


Eligibility criteria:
inclusion criteria: * bicoronal incision required as part of surgical plan * incision within hair-bearing scalp exclusion criteria: * previous bicoronal incision * unfit for surgery * unable to provide informed consent * unable to comply with followup * preexisting alopecia of scalp * cutaneous malignancy of scalp

Keywords: alopecia coronal incision scar quality
prognostic value of echocardiographic parameters based on machine learning approach

Conditions: Transthyretin Cardiac Amyloidosis

Summary: transthyretin cardiac amyloidosis is an increasingly recognized cause of heart failure with preserved ejection fraction. its diagnosis is currently based on a non-invasive method including biology and imaging. still currently incurable, the evolution of this pathology is burdened by numerous comorbidities, including iterative hospitalizations for heart failure leading to death. the machine learning approach has already shown its efficiency in terms of diagnosis but its prognostic approach has not yet been studied.


Eligibility criteria:
inclusion criteria: * patients with suspicion of transthyretin cardiac amyloidosis * age ≥18 years exclusion criteria: * lack of data to confirm or overturn the transthyretin amyloidosis diagnostic * echocardiographic data not allowing deep analysis (technical default, bad echogenicity of the patient) * final diagnostic of al or aa amyloidosis
chronic pain management after herniorraphy

Conditions: Chronic Pain

Summary: nowadays, chronic pain mainly as a result of iatrogenic nerve damage is generally considered as the most frequent complication after inguinal hernia surgery. the primary objective of this randomised double-blind placebo-controlled trial is to investigate whether pregabalin reduces pain in patients with chronic pain of neuropathic origin after herniorraphy.


Eligibility criteria:
inclusion criteria: 1. history of unilateral inguinal herniotomy 2. establishment of neuropathic character of chronic pain by means the lanss painscore and dn4 score 3. abnormal sensitivity (allodynia, dysesthesia, hypoesthesia or dysesthesia) in or around the incisional area 4. duration pain ≥ 3 months 5. medial or lateral inguinal hernia 6. age ≥ 18 years 7. vas score ≥ 40 mm on vas scale on which they indicate 'how unpleasant or disturbing the worst pain was that they had today' 8. grade iii or iv pain and discomfort on the 4-point pain and discomfort scale 9. informed consent (addendum v) exclusion criteria: 1. participation in another trial 2. age \< 18 years 3. cognitive disfunction 4. patient is unable to speak dutch 5. hereditary problems of galactose intolerance, lapp lactase deficiency or glucosegalactose malabsorption 6. patient classified as american society of anaesthesiologist class 4 7. renal impairment

Keywords: inguinal hernia chronic pain pregabalin chronic pain after inguinal herniorraphy
feasibility of slow continuous ultrafiltration for deresuscitation in critically ill patients

Conditions: Fluid Overload

Summary: to determine the feasibility and safety of deresuscitation using slow continuous ultrafiltration with regional citrate anticoagulation and peripheral or standard central venous access.

fluid deresuscitation has been shown to have favourable outcomes in the management of the critically ill patient. whilst diuretic medications have previously been the mainstay of achieving this deresuscitation, the metabolic and biochemical complications associated with their use can limit their application. mechanical ultrafiltration is another means of achieving fluid deresuscitation and has theoretical benefits over the use of intravenous diuretics. it allows a more titratable process, without the potential metabolic complications. the use of ultrafiltration has been limited by the requirement of wide bore central venous access. the scuffd study is a means of assessing whether ultrafiltration with regional anticoagulation can be achieved through standard central or peripheral venous access.

Eligibility criteria:
inclusion criteria: * adults (\>18 years) * evidence of fluid overload (greater than trace amount of peripheral oedema in \>1 site, pulmonary oedema on chest radiograph, or positive fluid balance equivalent to \>5% body weight) * clinician intention to target a negative fluid balance * expected to remain in a critical care setting beyond the next calendar day exclusion criteria: anticipated unavailability of suitable vascular access * lack of commitment to full support * receiving or imminently planned to receive renal replacement therapy * hyponatraemia (sodium \<130mmol/l) * hypernatraemia (sodium \>150mmol/l) * significant metabolic alkalosis (bicarbonate\>30 and ph\>7.5) * significant metabolic acidosis (hco3- \<18 mmol/l and ph \< 7.30) * uncorrected hypokalaemia (potassium \<3.0mmol/l) * liver failure (child-pugh grade b or above) * shock (any of: lactate \>3mmol/l, extensive skin mottling, central capillary refill time\>3 seconds, more than 1 vasoactive agent in use, noradrenaline dose \>0.2 mcg/kg/min, use of dobutamine, adrenaline, milrinone, enoximone or levosimendan) * receiving any systemic anticoagulation other than for routine venous thromboembolism prophylaxis, or dual antiplatelet therapy * prisoner * known pregnancy

Keywords: ultrafiltration deresuscitation