Kornimate/medical-research-clean huggingface dataset:
balance eyesight and muscle tension in the cervical spine in cerebral amyloid angiopathy

Conditions: Cerebral Amyloid Angiopathy

Summary: cerebral amyloid angiopathy (caa) is one form of disease of the small vessels of the brain and can cause frequent cerebral hemorrhages as well as other types of stroke. the aim of the research was to examine the balance of the body in patients after a stroke and to determine how the tension of selected muscles of the cervical spine changes under the conditions of statics and dynamics, depending on the visual control or its absence.

this is an observational study. the tests were performed with the use of tools and devices such as the unterberger test, biodex sd balance platform, and luna emg. the static equilibrium was assessed on a balance platform (stability test). the dynamic equilibrium was tested in the unterberger test and on the balance platform (the fall risk test). all examinations were performed twice with eyes open and then closed. additionally, during the tests, the tension of selected muscles of the cervical spine was recorded (the sternocleidomastoid muscle and the long neck muscle) (independent variables). it was examined how the intervention, static position, and dynamic displacement of the center of body mass, as well as the control and lack of eye control, influence the tension of selected muscles, and how the eyesight influences the body's balance in statics and dynamics (dependent variables). a group of healthy people was examined to assess whether neurological deficits in people after stroke could affect the results of static and dynamic balance and changes in muscle tone and whether the organ of vision plays a large role in controlling the center of body mass.

Eligibility criteria:
patients inclusion criteria:1) stroke in the course of caa; 2) the functional state of the patients, which allows independent walking in a place and at a distance; 3) no severe deficits in communication, memory, or understanding what can impede proper measurement performance; patients exclusion criteria: 1) cause of stroke other than caa; 2) stroke up to seven weeks after the episode; 3) epilepsy; 4) lack of trunk stability; 5) lack of independent walking; 6) high or very low blood pressure, dizziness, malaise. healthy inclusion criteria: 1) the control group consisted of healthy subjects with a stable trunk; 2) with independent walking. healthy exclusion criteria: 1) a history of neurologic or musculoskeletal disorders such as stroke or brain injury or other conditions that could affect their ability to active movement the trunk and the legs; 2) pain, dizziness; 3) permanent use of orthopedic supplies; 4) severe deficits in communication, memory, or understanding what can impede proper measurement performance; 5) high or very low blood pressure, dizziness, malaise.

Keywords: stroke, caa, upper limb, trunk exercises, stabilization
application of "i-anticoagulation"in patients with atrial fibrillation

Conditions: Atrial Fibrillation; Anticoagulants

Summary: the goal of this prospective, multicenter, cluster randomized controlled trial is to assess the effectiveness of a shared decision-making tool, "i-anticoagulation", for anticoagulation management in af patients. the main questions it aims to answer are: * whether "i-anticoagulation" could help improve the rational use of anticoagulants in af patients; * whether "i-anticoagulation" could help increase the adherence and satisfaction of af patients receiving anticoagulants. the anticoagulation therapy of af patients will be determined by clinicians with the use of "i-anticoagulation", and af patients will be managed using "i-anticoagulation" during their anticoagulation therapy. researchers will compare the outcomes with the control group, in which patients with af will receive standard care.


Eligibility criteria:
inclusion criteria: * patients who are 18 years or older and have received a new diagnosis of paroxysmal, persistent, or permanent af confirmed by electrocardiogram (ecg) or 24-hour holter monitors * must be willing to participate in the study and sign the informed consent exclusion criteria: * those who are pregnant * those whohave experienced therapeutic or subtherapeutic bleeding complications in the last 6 months * those who have severe renal insufficiency (creatinine clearance rate, crcl ≤ 20 ml/min) * those who have severe hepatic insufficiency (child-pugh ≥ 10 points) * those who have severe heart failure (cardiac function new york heart association, nyha grade iv and above) * those who have severe infection and respiratory failure * those who are unable to comply with the study requirements.
do common physical tests predict injury or performance

Conditions: Lower Extremity Musculoskeletal Injury

Summary: field tests are convenient, simple tests that serve as estimates of components of athletic performance like power speed, and agility. it is thought clinically, that those who do best at these tests will perform the best in their sport and/or be the least likely to get injured. the converse is also thought to be true. the objective of this study is to administer field tests to athletes at the beginning of each season and then follow athletes over several years, tracking their injuries and their performance statistics. in this way, the investigators can determine if the clinical supposition is true and that the results of field tests are associated with injury or performance

11 physical performance tests were examined to determine their ability to predict injury

Eligibility criteria:
inclusion criteria: * age18-23 * member of the university's varsity teams exclusion criteria: * injured or recently injured prior to testing * diagnosed current neurological issue * recent (within 6 weeks) surgery where strenuous physical testing would be contraindicated
technology-enabled collaborative care for young adults with type 1 diabetes and diabetes distress: a feasibility trial

Conditions: Type 1 Diabetes (T1D); Diabetes Distress

Summary: the goal of the study is to evaluate the acceptability and feasibility of a co-designed, technology-enabled collaborative care for young adults with type-1 diabetes and diabetes distress (tecc-t1d3) program. through this program, the investigators aim to deliver a collaborative care intervention, featuring a health coach and a virtual care team, designed to help participants manage mental health and overall wellbeing.

a total of 60 young adults with type 1 diabetes (t1d) will be enrolled in the study. participants will be randomly allocated to either a coaching intervention or an education intervention for 12 weeks. during the 12-week program, participants in the coaching intervention will take part in 8-10 sessions with a health coach, where experiences living with diabetes and goals related to diabetes management, communication with a support system, and overall wellbeing will be discussed. participants in the education intervention will receive generalized educational messages about diabetes and diabetes distress exclusively via automated emails. before and after the program, participants will complete surveys to provide an understanding of how diabetes and diabetes-related distress are being managed. after completing the respective interventions, participants will have a one-on-one interview with the research team to discuss their experience with the program and potential areas for improvement. the goal of the program is to enhance the quality of life for young adults with t1d who experience significant emotional burdens associated with the condition. the study addresses a critical research gap by integrating mental health support with diabetes management, a need historically underserved in healthcare settings. by developing a structured mental health intervention that is accessible and scalable, the study addresses the need for a model of whole-person care that incorporates psychological aspects as part of standard diabetes management. the model of care and findings could potentially be applied to other chronic conditions, broadening the impact of the study beyond diabetes to other areas of chronic disease management.

Eligibility criteria:
inclusion criteria: * young adult (age 18-29 years) * resident of ontario * living with a self-reported diagnosis of t1d of at least 1 year * individual is community-living (people who live independently in the community and are not residing in a setting that provide institutional care or support) exclusion criteria: * unable to participate in english language * unable to participate via telephone or web-conferencing

Keywords: type 1 diabetes tecc model diabetes distress technology-enabled care young adults with t1d
pilot mobile for dementia and frailty

Conditions: Dementia; Frailty

Summary: in this project, we propose to build on our stage i formative work (according to the nih stage model for behavioral intervention development), where we developed fully functional prototypes of a mobile intervention aimed at improving adherence to mediterranean diet (medd) for older adults with frailty and early dementia to complete the stage ii exploratory work, where the intervention will undergo further feasibility, acceptability, and preliminary efficacy tests. the intervention includes a patient-facing app that allows users to track their diet and receive personalized feedback concerning opportunities for improvement and recipes for breakfast, lunch, dinner, and snacks, informational materials about medd, and a chat feature. on the other end, a web-based provider interface allows clinicians to review patient progress, suggest meal plans, and send and receive messages. the pilot randomized controlled trial, conducted over three months, will compare usual care to usual care plus mobile intervention to gather preliminary efficacy data concerning a change in adherence to medd score (primary outcome). mechanistic and secondary outcomes will include medd knowledge, constructs from social cognitive theory (self-efficacy, outcome expectation, self-regulation, and social support), platform use, anthropometric, and functional measures. feasibility will be evaluated in terms of recruitment and retention outcomes. acceptability will be determined through post-intervention semi-structured interviews and structured survey measures.


Eligibility criteria:
inclusion criteria: 1. 65 years or older; 2. icd-9-cm (icd-10-cm) codes for mild or major neurocognitive disorders with mild-to-moderate severity due to several possible etiologies. specifically, a) mild neurocognitive disorder 331.83 (g31.84); major neurocognitive disorder 294.1x (f02.8x) due to alzheimer disease 331.0 (g30.9); frontotemporal lobar degeneration 331.19 (g31.09); lewy body disease 331.82 (g31.83); 3. mild-to-moderate frailty 4. own a mobile device. exclusion criteria: 1. severe sensory impairment that makes it impossible to operate a mobile device or respond to prompts 2. english reading level below 6th grade 3. no care partner 4. optimal diet

Keywords: diet nutrition mediterranean diet
evaluating the role of intra-articular injections of platelet rich plasma (prp) in patients with rheumatoid arthritis.

Conditions: RA - Rheumatoid Arthritis

Summary: to evaluate the therapeutic effect of 3 local doses of prp intra-articular injection in patients with ra regarding the improvement of disease activity and quality of life versus placebo.

100 patients with ra fulfilling the 2010 acr-eular classification criteria for ra were recruited from the outpatient clinic of the rheumatology and rehabilitation department. all patients were subjected to clinical and laboratory assessment, visual analog score (vas) scale and health assessment questionnaire (haq). fifty patients were injected intra-articularly with 3 doses of prp and 50 patients who serve as a control injected with 3 doses of placebo at 4 weeks intervals for the tender joints and revaluated at 1, 3 months post the last injection regarding the same evaluating tools.

Eligibility criteria:
inclusion criteria: * patients diagnosed as ra regarding 2010 new criteria of ra, both sex,aged20-60 years old. exclusion criteria: * patients with local abscess, * systemic illness as (diabetes mellitus, malignancy), * patients on opioids analgesics. * pregnancy, blood disorders(coagulopathy, thrombocytopenia),
the impact of local analgesia for postoperative analgesia in posterior thoracolumbar operation

Conditions: Pain

Summary: posterior thoracolumbar operation always chooses general anesthesia. due to surgical trauma and rich periosteum and joint capsule innervation, patients after general anesthesia immediately feel acute pain.the use of appropriate postoperative analgesia in patients with thoracolumbar surgery is beneficial to postoperative recovery. infusions of local anaesthetic via multilumen catheters that deliver directly to wound sites have been used for postoperative analgesia in procedures. reducing the morbidity from both pain and nausea will make the mode of analgesia a better tolerated and more palatable option for patients. the aim of this study is to examine the effects of using local anaesthetic infusion catheters following posterior thoracolumbar surgery, and compares the outcomes of patients managed using intravenous analgesia pump infusion of systemic opioids.

all 71 adult patients were prospectively included and randomized to either the local (l) group (n=35) or the intravenous (v) group (n=36) by using a random number table: the test group were treated with local analgesia infusion pump of 0.33% ropivacaine through the wound for postoperative analgesia, while the control group were treated with intravenous analgesia pump infusion of flurbiprofen axetil,palonosetron, pentazocine. at 2, 4, 6, 12, 24, 36, 48 hours after operation, postoperative pain visual analogue scale(vas) scores and sedation ramsay scores were used to evaluate the level of pain and sedation, and investigators documented the comprehensive evaluation of patients with pain control system, and the incidence of adverse reactions. at 24, 48 hours investigators observed the wound whether inflammation and exudation or not, and the removal of penetration catheter sent to clinical laboratory for bacterial culture. investigators also recorded the length of time to discharge and called to ask pain conditions at the first 3 months.

Eligibility criteria:
inclusion criteria: 1. asa ⅰ \~ ⅱ patient undergoing elective posterior thoracolumbar operation 2. between 18 and 70 years of age exclusion criteria: 1. a history of cardiopulmonary disease, liver and kidney dysfunction, abnormal coagulation 2. preoperative use of analgesic drugs 3. a allergy history of ropivacaine and polyurethane material

Keywords: local analgesia system ropivacaine analgesic efficacy after operation postoperative
respiratory system compliance guided vt in moderate to severe ards patients

Conditions: Respiratory Failure; Acute Respiratory Distress Syndrome

Summary: the acute respiratory distress syndrome (ards) is one of common clinical critically diseases. in the united states, the incidence of ards reaches 31%, which is one of the main causes of death in patients. there is no unified treatment process for ards currently and the treatment measures are not yet standardized, so the standardization of ards treatment processes is needed to reduce mortality in patients. following the evidence-based medicine principles and six-step treatment standards of ards, this study uses the method of multi-center randomized controlled clinical trials to evaluate the standardized treatment process of ards, which provides the basis for the standardized treatment of ards.

from september 1st 2012 to september 30th 2014, all ards patients admitted to the icus will be enrolled. the demographic characteristics, diagnosis, formerly medical history, ventilator indications, ventilator data, other respiratory treatments, weaning outcome and 28 day mortality will be recorded.

Eligibility criteria:
inclusion criteria: 1. aged ≥ 18 years 2. admitted to the icu 3. according to the diagnostic criteria of ards berlin definition，admit patients with severe ards exclusion criteria: 1. age \<18 years old 2. be expected to die within 24 hours 3. end-stage malignancies 4. be participating in other studies, which may affect the results of this study 5. dni (do not intubation) and dnr (do not recovery) patients 6. family members do not agree to sign an informed consent

Keywords: mechanical ventilation ards ventilator strategy outcome
a study to determine the management of palmar-plantar erythrodysesthesia (ppe) in patients with metastatic ovarian or breast cancer treated with caelyx (study p05020)

Conditions: Ovarian Neoplasms; Breast Neoplasms; Paresthesia

Summary: the objective of this trial is to study the management of ppe in participants with metastatic ovarian or breast cancer treated with caelyx, and determine the frequency of use of pharmacological treatment (preventive or therapeutic) for ppe and compliance of educational recommendations for ppe.


Eligibility criteria:
inclusion criteria: * women 18 years of age or older. * participants with metastatic breast or ovarian cancer who are receiving treatment with pegylated liposomal doxorubicin. * participants who have given their written consent. exclusion criteria: * participants who are currently participating in a clinical trial.
steps to blood pressure reduction.

Conditions: Stroke Prevention; Blood Pressure Reduction

Summary: the stroke transitions education and prevention (step) clinic is a new type of clinic designed for stroke patients and was established to provide a comprehensive approach to stroke risk factor reduction. the goal of this study will be more effective than usual care at reducing blood pressure in patients with poorly controlled blood pressure after an ischemic or hemorrhagic stroke or transient ischemic attack.

step clinic patients will receive personalized goals, instructions to self-monitor, a blood pressure monitor, prescription medications, sleep apnea screening, dietary counseling, and more frequent follow-up if needed. a stroke neurologist will see patients in the usual care group and recommendations will be sent to their primary care providers.

Eligibility criteria:
inclusion criteria * age ≥ 18 * clinical ischemic stroke, intracerebral hemorrhage, or transient ischemic attack * plan to discharge home or to short stay inpatient rehab after stroke * two of following required: * history of hypertension (prior to hospitalization) * hospital blood pressure ≥ 140/90 on two or more occasions during hospitalization * discharge home on blood pressure medication * willingness and ability to follow-up in university of texas physicians stroke clinic exclusion criteria: * modified rankin scale (mrs) \> 3 at enrollment * terminal illness * chronic kidney disease stage 4 or greater (egfr \< 30) * pregnancy * symptomatic flow limiting carotid stenosis without plan for intervention prior to clinic visit * stroke etiology presumed unrelated to atherosclerotic risk factors (amyloid angiopathy, vasculitis, malignancy associated)
3d reconstruction in video-assisted thoracoscopic surgery (vats) segmentectomy

Conditions: Segmentectomy

Summary: anatomical variations of pulmonary vessel may cause serious problems during pulmonary segmentectomy. three-dimensional （3d）computed tomography (ct) presents 3d images of pulmonary vessels and the tracheobronchial tree and may help operative planning. retrospective studies have identified the importance of 3-dimensional ct in the field of pulmonary segmentectomy. and the aim of this study is to compare the usefulness of 3-dimensional ct with standard chest ct in preoperative planning of video-assisted segmentectomy.

lung cancer has been the most serious malignancy around the world which has the highest morbidity and mortality amount all the malignant tumors. due to the wide spread of lung cancer screening, more and more early stage lung cancer patients have been diagnosed. video-assisted segmentectomy is a standard surgical procedure in treating early stage peripheral non-small cell lung cancer (nsclc). however, anatomical variations of pulmonary vessel may cause serious problems, for example unexpected bleed during surgery. three-dimensional computed tomography (ct), which is reconstructed based on the standard chest ct image, presents 3d images of pulmonary vessels and the tracheobronchial tree and therefore helps operative planning. there are several retrospective studies addressed the importance of 3-dimensional ct in the field of pulmonary segmentectomy. and the aim of this multicenter randomized controlled trial is to compare the usefulness of 3-dimensional ct and standard chest ct in preoperative planning of video-assisted segmentectomy.

Eligibility criteria:
inclusion criteria: 1. age older than 18 years; 2. pulmonary nodules or ground glass opacification （ggo） found in chest ct examination, and conform with indications for segmentectomy: peripheral nodule 0.8-2 cm with at least one of the following: i. histology of adenocarcinoma in situ; ii. nodule has ≥50% ground-glass appearance on ct; iii. radiologic surveillance confirms a long doubling time (≥400 days). segmentectomy should achieve parenchymal resection margins ≥2 cm or ≥ the size of the nodule. 3. adequate cardiac function, respiratory function, liver function and renal function for anesthesia and vats segmentectomy. 4. american society of anesthesiologists (asa) score: grade i-iii. 5. patients who can coordinate the treatment and research and sign the informed consent. exclusion criteria: 1. patients with a significant medical condition which is thought unlikely to tolerate the surgery. for example, cardiac disease, significant liver and renal function disorder. 2. patients with psychiatric disease who are expected lack of compliance with the protocol. 3. patients have history of chest trauma or surgery on ipsilateral chest which may cause pleural adhesion.

Keywords: segmentectomy video-assisted thoracoscopic surgery lung cancer ground-glass opacity
expectant versus immediate medical management for the evacuation of the no evolutionary pregnancies before 13 gw

Conditions: Pregnancy Complications

Summary: compared the interest of one week expectancy vs immediate medical treatment in the taking care of the evacuation of the no evolutionary pregnancies before 13 gw.

randomized control trial comparing one week expectancy vs immediate medical treatment (mifepristone 200mg and misoprostol 400ug) in the taking care of the evacuation of the no evolutionary pregnancies before 13 gw.

Eligibility criteria:
inclusion criteria: * agreed women aged over 18 yrs old non evolutive pregnancy before 13gw : * non evolutive pregnancy with no fetal cardiac activity * non evolutive pregnancy with embryonic structures * trophoblastic material in uterine cavity p bhcg \< 10ui/l exclusion criteria: * age \< 18 years * pregnancy evolutionary * not evolutionary pregnancy after 13 weeks of amenorrhoea characterized by the presence of an scan image intra-uterine anechogene furthermore of 50mm of diameter * amenorrhoea of more than 13 weeks * pregnancy twin * pregnancy molar * pregnancy extra-uterine * extra-uterine pregnancy * one or many contraindications in the mifepristone: * allergy known about the mifepristone * incapacity suprarenal * corticosteroid therapy in the long price * confusions of the haemostasis (thrombopenia \< in 100000 / mm3) * anaemia (rate hg \< in 9 g / dl) * contraindication in the misoprostol * allergy known about prostaglandines * beance cervical

Keywords: pregnancy complications