Kornimate/medical-research-clean huggingface dataset:
ensure cardiac resynchronization therapy study

Conditions: Heart Failure

Summary: the purpose of this study is to gather information on how doctors program particular settings on cardiac resynchronization therapy implantable cardiac defibrillators (crt-ds), to analyze how these settings affect the amount of cardiac resynchronization therapy (crt) patients receive and to evaluate the therapy approach for converting abnormally fast heartbeats into normal heartbeats. there are no experimental devices or procedures involved in this study.


Eligibility criteria:
inclusion criteria: * patient is indicated for a medtronic crt-d system * patient is willing to sign permission for access to and use of health information form * patient is willing and able to comply with follow-up visits through six months exclusion criteria: * patient has a life expectancy of less than 6 months * patient is participating in any concurrent study that could confound the results for either study

Keywords: observational heart failure continuous cardiac resynchronization therapy
treatment of pilonidal sinus disease using surgiflo as a sealant: a new concept

Conditions: Pilonidal Sinus Disorder

Summary: assessment of surgiflo injection for treating pilonidal sinus disease

evaluation of injection of surgiflo as a sealent in treatment of pilonidal sinus, evaluation includes recurrence, infection, complications and patient satisfaction over 2 years of follow up

Eligibility criteria:
inclusion criteria: patients included in the study had simple midline ps with single or multiple tracts and no lateral extensions. recurrent cases of ps after previous surgery were also included in the study exclusion criteria: we excluded from the study patients with severe scarring at the natal cleft due to previous surgery or infection and patients with signs of an acute abscess.
training for men undergoing androgen deprivation therapy.

Conditions: Prostate Cancer

Summary: the goal of this clinical trial is to evaluate the effects of a newly developed training concept on men with prostate cancer undergoing androgen deprivation therapy (adt). the main questions it aims to answer are: * how feasible and safe is the new training concept? * how efficient is the training concept to counteract side effects caused by adt? researchers will compare the new training concept with usual care to evaluate how efficient the training concept is to counteract the adt-related side effects. participants in the intervention group will perform the new training concept twice weekly for 12 weeks. participants in the control group will only receive usual care. all participants will visit the laboratory at baseline and after 6 and 12 weeks to measure the primary and secondary outcomes.

detailed description of the training concept applied in the intervention: the two weekly training sessions will be separated by at least two days and supervised by appropriately trained exercise professionals at the swedish school of sport and health sciences. the training includes a 10 min warm-up followed by 3-4 sets of 8 maximal repetitions on the flywheel machine followed by 16-24, 20 s intervals on a monark cycle ergometer. the intervals will be performed as 3 blocks with the intention to execute 8 intervals in each block. when a participant manages to perform all 3 blocks with 8 intervals in each block (a total of 24 intervals) the resistance will be increased by \~20 w. the rest period between the intervals will be set to 10 s and the rest between the blocks to 2 min. the starting workload of the intervals will be individually adjusted to \~115 % of the participant's power output at vo2peak. the total duration of a training session will be 30-40 min (including worm-up).

Eligibility criteria:
inclusion criteria: 1. signed informed consent 2. histologically confirmed localised or locally advanced prostate cancer 3. planned radiotherapy in combination with adt for at least six months (unfavorable intermediate risk and high-risk prostate cancer) with curative intent and with no known metastasis. exclusion criteria: 1. very high risk localised prostate cancer planned for radiotherapy and adt plus abiraterone and cortisone 2. localized prostate cancer planned for radiotherapy without adt 3. on-going or previously treated with adt or other hormonal treatments 4. have any contraindications to physical testing/exercise as per the acsm guidelines 5. unable to comply with study procedures

Keywords: androgen deprivation therapy (adt) flywheel training high intensity training (hit) resistance training aerobic training
mediterranean diet versus paleolithic diet for the treatment of non alcohlic fatty liver disease

Conditions: Non-Alcoholic Fatty Liver Disease

Summary: non- alcoholic fatty liver disease (nafld) is one of metabolic syndrome manifestation, and has become the leading cause for cirrhosis and the need for liver transplantation. the mediterranean diet showed in many trials its benefit in the treatment of the metabolic syndrome and nafld. the paleolithic diet includes meat, fish, fruits, vegetables, nuts and seeds and avoidance of processed food and most of carbohydrates. in some studies this diet seemed to decrease triglycerides levels and improve insulin resistance. the aim of this study is to evaluate the influance of the paleolithic diat for the treatment of nafld, as shown in the mediterranean diet.

recruitment of 60 patients with the diagnosis nafld from clinics in rabin medical center, aged 18-65. two study groups- mediterranean diet and paleolithic diet the dietitian will assign randomly for the study groups, and will assess diet adherence within 6 weeks of the trial and in its end- after 3 months. blood test for liver enzymes, lipids, crp, mda and hba1c, will be taken at recruitment and after 3 months. ultrasound and elastography will be tested at recruitment and after 3 months, to evaluate the degree of the fatty liver, by a the same doctor who is blind to the study groups.

Eligibility criteria:
inclusion criteria: * nafld exclusion criteria: * pregnancy * chronic kidney disease * post transplant
endoscopic treatment of rectal neuroendocrine tumor(net) less than 10mm

Conditions: Rectal Neuroendocrine Tumor

Summary: cap-assisted endoscopic mucosal resection (emr-c) and endoscopic submucosal dissection (esd) have both been reported to be effective treatment methods for small rectal neuroendocrine tumor (net) in limited studies. which one is better has not been determined. we aimed to compare the efficacy and safety of emr-c and esd for the treatment of small rectal net.


Eligibility criteria:
inclusion criteria: * age from 18 to 75 years; * definite diagnosis of rectal net less than 10mm; * patients plan to receive either emr-c or esd treatment. exclusion criteria: * serious comorbid diseases such as advanced malignant tumor and organ failure; * patients received conventional emr, snare electrotomy and no treatment; * rectal net with metastasis; * pregnant patient; * poor compliance
functional and anatomical mri of the spinal cord and peri-spinal tissues

Conditions: Chronic Pain; Other Functional Disturbances Following Cardiac Surgery

Summary: the current study is an amendment to a previously approved blinded randomized controlled trial (nct02697812) which examines the rate at which the sternal retraction maneuver is performed during cardiac surgery (standard over 30 seconds versus. gradual over 15 minutes) and examines the incidence of chronic post-sternotomy pain 6 months following surgery. patients enrolled in the parent study will be identified at the 6 month follow-up and recruited in terms of whether they report chest pain. a total of 30 participants will be recruited (15 with and 15 with no pain) to undergo a single mri session in which functional mri will be done on the brain stem and spinal cord and anatomical mri images will be collected for specific chest and neck structures. this will indicate whether there are long-term differences in pain processing and/or physical damage to neck and chest structures in those with and without chronic pain 6 months following coronary artery bypass graft surgery. all functional and anatomical mri images will be reviewed and interpreted with study personnel blinded to whether the patient is reporting pain or no pain at their 6 month follow-up interview.


Eligibility criteria:
inclusion criteria: * elective primary coronary artery bypass surgery * understanding and provision of written informed consent * age \> 18 and \< 75 * asa class i, ii or ii exclusion criteria: any combined or redo cardiac procedure * current alcohol or substance abuse * pre-existing chronic pain requiring chronic analgesic use * rest pain in proposed surgical area at baseline, preoperatively * chronic steroid use * inability to perform post-operative assessments

Keywords: magnetic resonance imaging central pain processing anatomical mri fmri
ear plugs versus acupressure for management of severe gag reflex

Conditions: Gagging

Summary: the aim of this study is to evaluate the efficacy of two proposed non-invasive techniques: the ear plug technique and acupressure on the p6 point in reducing gag reflex during impression making and to assess patient's experience in terms of comfort and satisfaction.

the study will take place at the clinics of riyadh colleges of dentistry and pharmacy (rcsdp) in riyadh, saudi arabia. patients, who on previous occasions have demonstrated difficulties in accepting the procedure of making impressions of maxillary teeth due to a severe gag reflex (gr) will be invited to participate in the study. a randomized single blinded clinical trial will be conducted on 30 participants who fulfill the inclusion criteria. participants will be assigned to three separate groups. for each patient, two maxillary alginate impressions will be made; one before applying the proposed management technique and one after. participants of group ep (n=10) will be managed using earplugs while group ac (n=10) will be managed using acupressure band and group pl (n=10) will receive placebo management in forms of regular bands. informed consent will be obtained from all participants. all impressions will be made by one dentist that will be blinded to the gag reflex (gr) management techniques. the gr evaluation for all the participants will be performed by another calibrated dentist who is also blinded to the applied technique. the severity of gag reflex will be assessed during making of the first impression using dickinson \& fiske (2005) gagging severity index (gsi). after 20 minutes of making the first impression, participants of group ep will be asked to place the earplugs in and wait in the waiting room for 10 minutes. then, the second impression will be made while the participant still has the earplugs on. group ac will have acupressure technique via sea aid bands which will be placed on the p6 points of both hand wrists. participants will be asked to wait in the waiting room for 10 minutes then the second impression will be made. pl group will have the placebo management via placebo bands ( with no pressure points ) which will be placed on both hand wrists. participants will also be asked to wait in the waiting room for 10 minutes then the second impression will be made. the effectiveness of the treatment will be assessed using dickinson \& fiske (2005) gagging prevention index (gpi). participants will be asked to rate their discomfort during impression making using visual analogue scale (vas).

Eligibility criteria:
inclusion criteria: * the individual is able to give informed consent. * patients with gr severity that are assigned to a gagging severity index (gsi) iii-iv (for standardization of the baseline severity in between groups). exclusion criteria: * pregnant women * patients with chronic heart diseases or cardiac pacemakers * patients with central or peripheral nervous system disorders * patients with oral lesions * patients with gastrointestinal disorders.
wedge resection or parietal pleurectomy for the treatment of recurrent pneumothorax (wopp)

Conditions: Pneumothorax; Recurrent Pneumothorax

Summary: primary spontaneous pneumothoraces (psp) represent a significant public health problem, occurring in young healthy subjects without pre-existing lung disease or precedent medical intervention or trauma with a reported incidence of up to 18-28/100 000 per year. psp treatment often requires thoracic surgery to restore lung expansion and to prevent de novo lung collapse. despite the presence of elaborated guidelines by the british thoracic society (bts) postulating apical wedge resection of the lung and total parietal pleurectomy (wrpp), the majority of german hospitals gathered experience especially in limiting surgery to cost-saving partial apical parietal pleurectomy or yet apical pleural abrasion (pp). until today, hardly any reliable data exist to analyze and compare the varying treatment approaches regarding efficacy and efficiency. in this randomized, multi-centric clinical trial, both treatment approaches will be compared. for this purpose, candidates for surgery will be randomized into one of the two treatment groups after informed consent has been obtained. patients will be followed for 2 years by the participating centres to be able to evaluate the long-term effect of the surgical interventions.

the trial will be conducted at the major thoracic surgery units in germany. each centre can include patients on the basis of the presence of a psp and the inclusion and exclusion criteria. after informed consent has been obtained from the study participants, each has to fill out the standardized short-form health survey (sf-36) questionnaire and the visual analogue scale (vas) to determine baseline parameters for the (current) state of health and pain level.randomization into the two interventional groups is carried out before surgery. patients are operated according to good clinical practice either by pleurectomy alone (pp) or total parietal pleurectomy with apical wedge resection of the pulmonary apex (wrpp). procedure related parameters (like operation time, applied suture materials including staplers) are documented. the postoperative care is subject to each participating centre's standards. the postoperative course is evaluated (mortality, morbidity, duration of tube drainage, re-interventions or operations, length of stay, need for blood substitutions). to evaluate the long term effect of the surgical intervention, all study participants are followed for 2 years.

Eligibility criteria:
inclusion criteria: * recurrence of a primary pneumothorax * persistent primary pneumothorax * patient preference (in primary events) exclusion criteria: * presence of a pulmonal fistula * underlying lung disease * previous thoracic surgery (except tube thoracostomy) * previous pleurodesis * conversion thoracotomy

Keywords: pneumothorax primary pneumothorax lung collapse
improving influenza vaccination rates among health care professionals

Conditions: Influenza

Summary: the purpose of this study was to see if reminder letters and a large raffle prize would encourage health care workers to receive influenza vaccinations.

eight hundred employees of an urban tertiary care hospital, 200 each from the following four categories: professional staff, resident physicians, registered nurses, and licensed practical nurses comprised the study group. subjects were randomly assigned to receive: 1) no intervention, 2) a reminder letter for flu vaccine, 3) a raffle ticket to win a free caribbean vacation with flu vaccine administration, or 4) both the reminder letter and raffle ticket. we compared the proportion of employees receiving vaccination and participating in the raffle across groups.

Eligibility criteria:
inclusion criteria: * hospital employees, staff physicians, residents, rn's, lpn's exclusion criteria: * non patient care hospital employees

Keywords: influenza vaccine influenza immunization reminder letters raffle prize
adjuvant chemotherapy for locally advanced cervical cancer

Conditions: Uterine Cervical Cancer

Summary: data of survival benefit from adjuvant chemotherapy (act) after concurrent chemoradiation (ccrt) for locally advanced cervical cancer (lacc) are still limited and inconsistent. we will investigate if act has survival benefit over ccrt alone.

concurrent chemoradiation (ccrt) is the standard treatment for cervical cancer of figo stage iib-iva or so called locally advanced cervical cancer (lacc). however, failure rate after treatment is still as high as 30% to 40%. this is a multi-center randomized controlled trial which evaluates whether adjuvant chemotherapy (act) after ccrt will improve treatment outcome comparing to ccrt alone.

Eligibility criteria:
inclusion criteria: * age 18-70 years * cervical cancer figo stage iib-iva * histopathology of squamous cell carcinoma, adenocarcinoma, or adenosquamous cell carcinoma * ecog performance status 0-2 * no history of other cancer except basal cell carcinoma * adequate bone marrow function (wbc \> or = 3,000/mm3, granulocytes \> or = 1,500/mm3, platelet count \> or = 100,000/mm3) * bilirubin \ or = 40 mg/dl * consent to participate exclusion criteria: * para-aortic lymph node enlargement \> 1 cm or suspicious for cancer metastasis from ct or mri * adnexal mass from physical examination or imaging study * chronic illnesses e.g. renal failure/ impairment, peripheral or central neuropathy, uncontrolled diabetes mellitus, or hiv infection. * pregnancy or lactation

Keywords: locally advanced cervical cancer concurrent chemoradiation adjuvant chemotherapy
endothelial cell loss and induced astigmatism after wound-directed and wound-assisted iol injection

Conditions: Cataracts; Cataract Surgery

Summary: the purpose of this study is to determine if there is any difference in astigmatism (eye surface curvature) or corneal endothelial cell density (the inner cell lining of the eye surface) after two different methods for inserting a lens during cataract surgery.

cataract surgery (removal of a cloudy lens) is currently performed through increasingly smaller incisions. bimanual surgery, where two instruments are used to remove the lens, is performed through two 1.4 mm incisions. typically, one of these incisions is enlarged to 2.2 or 2.4 mm in order that the iol (artificial lens) can be inserted into the eye. surgeons insert these lenses by placing a lens injector cartridge completely into the eye (wound-directed insertion) or by placing only the tip inside the incision (wound-assisted insertion). while wound-assisted insertion can be performed through slightly smaller incisions (2.2 mm versus 2.4 mm for wound-directed insertion), both methods of insertion cause some incision enlargement. there is some evidence that wound-assisted insertion can cause very short-term pressure within the eye to go up. neither method is considered inferior or superior to the other, and the primary investigator (dr. kenneth cohen) routinely uses both methods. no studies have directly compared wound-healing characteristics between these two methods. we seek to compare differences in: 1. surgically-induced astigmatism (changes in the corneal curvature from cataract surgery incisions. 2. endothelial cell density loss. endothelial cells line the inside surface of the cornea, and their overall density can be decreased by cataract surgery. 3. best-corrected vision after surgery 4. sizes of the incisions after lens injection

Eligibility criteria:
inclusion criteria: * eligible patients include those who undergo uncomplicated cataract extraction surgery and iol implantation by klc. exclusion criteria: patients who: 1. suffer from diabetes and have more than mild background diabetic retinopathy, 2. have a history of intraocular surgery, 3. have a history of ocular trauma, 4. have known pathology of the cornea, 5. have a history of intraocular inflammation, 6. are unable to understand english, 7. are decisionally impaired, 8. are currently incarcerated, or 9. are less than 18 years of age. no exclusions will be made on the basis of gender, ethnicity, or race.
biomarkers of pancreatic cancer and new way to detection

Conditions: Pancreatic Cancer

Summary: amphoteric regulatory protein (areg), a member of epidermal growth factor (egf) family, is expressed in many tumors.our study confirmed that the expression of areg in the serum of patients with pancreatic cancer is significantly higher than that of patients with benign pancreatic diseases and healthy people, which is expected to become a new early serum marker of pancreatic cancer. the serum concentration of areg was detected by traditional elisa and compared with ca-199, which was a conventional tumor marker of pancreatic cancer. next, we compare the advantages of using sensor to detect areg compared with elisa.

serum was collected ： pancreatic cancer : healthy control =200:200 clinical data were collected: age, gender, diagnosis, cancer stage, ca199 level at initial diagnosis, histopathological type, etc. the informed consent of the subjects was obtained before the study, and all experimental procedures were approved by ethics. draw a summary table of patient characteristics. the level of areg was detected by elisa kit and compared with ca199. fabrication of a new electrochemical biosensor. characterization of sensor performance.

Eligibility criteria:
inclusion criteria: * the healthy control group had no history of benign pancreatic diseases and other benign and malignant tumors. * patients with pancreatic cancer did not receive any anti-cancer treatment and had no history of other malignant tumors.the diagnosis of pancreatic cancer patients is based on the final pathological diagnosis; the cancer staging is based on ajcc staging manual. exclusion criteria: * uncontrolled active infection. * acute or chronic pancreatitis. * it is accompanied by other uncontrolled malignant tumors. * any other uncontrolled active disease that prevents participation in the trial. * having a history of mental illness that is difficult to control. * in the opinion of the investigator, the presence of medical or psychiatric history or laboratory abnormalities may increase the risk associated with participation in the study or the administration of the study drug, or may interfere with the interpretation of the results.