Kornimate/medical-research-clean huggingface dataset:
molecular analysis of childhood and adolescent melanocytic lesions

Conditions: Melanoma

Summary: this is an observational, non-therapeutic study to collect clinical and molecular information of pediatric patients with childhood melanocytic lesions. primary objective: to perform a comprehensive molecular analysis of samples either from paraffin embedded and/or frozen tissue from patients with pediatric melanocytic lesions (including melanoma, spitzoid melanoma, congenital melanoma, melanoma arising in giant nevi). secondary objective: to collect minimal information on patients treated with adjuvant or systemic therapies according to national comprehensive cancer network (nccn) guidelines.

investigators will study the dna and rna in tumor cells and blood cells to look for changes that may be related to the development of the tumor, as well as changes that may influence how the tumor responds or doesn't respond to treatment. normal blood cells will be studied to compare to the tumor cells. investigators will also look at basic information about the treatment received and how the tumor responds, i.e. what kind of chemotherapy, surgery, radiation treatment, or other therapy the participant received, whether they had serious side effects, and how well the tumor responded to the treatment. as part of regular medical care, tumor will be obtained to determine the type of cancer. for participants who consent to this study, leftover tumor tissue not needed for diagnosis or regular medical care will be studied at st. jude children's research hospital where scientists will look for changes in the genes of the tumor cells. no additional surgeries or procedures are needed for this study. a small amount of blood (2-3 tablespoons) will be collected and analyzed to determine if the genetic changes in the tumor cells are also found in the blood cells. small children (\<42 lbs.) will have a smaller amount drawn (1-2 tablespoons).

Eligibility criteria:
inclusion criteria: * participant has a suspected or confirmed diagnosis of a melanocytic lesion, including: * conventional or "adult-type" melanoma * spitzoid melanoma/atypical spitz tumor * congenital melanoma * melanoma arising in a giant congenital nevus * melanocytic lesions with indeterminate biological behavior (e.g., pigment synthesizing melanomas) * participant was \<19 years of age at the time of diagnosis. * tissue is available for biologic studies. * participant has been enrolled on the tbank protocol at sjcrh, or will be enrolled before any research tests are performed on their biological materials. exclusion criteria: * ocular melanoma * inability or unwillingness of research participant or legal guardian to consent. * histologic diagnosis other than melanocytic lesion described in 3.1.1.

Keywords: melanoma spitzoid melanoma congenital melanoma melanoma arising in giant nevi melanocytic lesions with indeterminate biological behavior pigment synthesizing melanomas
social impact of children's dental appearance

Conditions: Dental Caries in Children

Summary: this study evaluates the social impact of children's dental perception from children with or without caries experience. for this, children and their parents are shown pictures of child faces with healthy teeth, decayed teeth and teeth after dental treatment.

appearance and abnormalities in the face influences the life of children: attractive children get estimated as more competent and find friends easier than those with a less attractive appearance. therefore this study aimes to evaluate the social impact of children's dental perception from children with or without own caries experience (and their parents). both groups (with/without caries experience) are shown pictures of children with different dental status (healthy teeth, decayed teeth and teeth after dental treatment) and asked to complete established questionnaires.the division into the groups is based on photos of the children with visible teeth. the results should be evaluated descriptively and graphically. also the comparison between the answers of both groups for the three different dental status is planned.

Eligibility criteria:
inclusion criteria: * (parent of an child of) age 4-9 years * sufficient compliance * dividable into the two groups (with or without caries experience) exclusion criteria: * missing agreement to participate in the study * insufficient compliance

Keywords: early childhood caries children dentistry face perception dental appearance
effectiveness of glove changing in reducing wound-related complications

Conditions: Wound Complication

Summary: this study aimed to investigate the effectiveness of glove changing in reducing complications of cesarean deliveries in vietnam.

in vietnam, the rate of cesarean section (cs) is very high, ranging from 40-50%. despite that, there are very limited publications concerning the risk factors, complications, and management of surgical site infection (ssi) following cs. our study is the first to investigate the effectiveness of glove changing in reducing the incidence of post-operative infections in vietnam. specifically, the aims of this study are 1) to evaluate whether changing gloves during cs reduces complications and ssi, and 2) to identify other factors that are associated with complications and ssi.

Eligibility criteria:
inclusion criteria * pregnant women were 18 years old or higher; * pregnant women had cesarean surgery performed at hung vuong hospital; * pregnant women lived close to ho chi minh city and agreed to return for postpartum care one-month post-surgery. exclusion criteria * pregnant women had fever during labor; * pregnant women had systemic infectious conditions; * pregnant women had surgical site infection ssi or sexually infectious conditions; * pregnant women had ongoing internal conditions such as pre-eclampsia, severe anemia, american society of anesthesiologists (asa) ≥ 3, new york heart association (nyha) class 3 or above, pulmonary edema, or severe asthma.

Keywords: complications glove changing eesarean surgery infections vietnam
the diagnostic accuracy of advanced imaging in identifying suspected skin cancer (basal cell carcinoma) around the eyes

Conditions: BCC - Basal Cell Carcinoma; BCC; Skin Diseases; Eyelid Tumor; Eyelid Diseases

Summary: the purpose is to investigate the diagnostic value (sensitivity and specificity) of dermal-optical coherence tomography (d-oct, vivosight dx), in patients with clinically suspected bcc lesions inside the periocular region and compare these results to previous reports using d-oct in diagnosing lesions outside the periocular area. the hypotheses: * the sensitivity and specificity of d-oct in diagnosing bcc inside the periocular region is comparable to previous reports on bcc lesions outside the periocular region when the standard d-oct probe is used. * the sensitivity and specificity of d-oct in diagnosing bcc inside the periocular region is increased when the customised d-oct probe is used. * the sensitivity and specificity of d-oct in diagnosing periocular bcc is comparable to punch biopsy when both standard and the customised d-oct probes are used. * d-oct with the 10 and 20-millimeter standoff is capable of subtyping periocular bcc. * the inter-observer variation in diagnosing and sub-typing periocular bcc decreases with increasing experience in the scanning procedure. * the number of scans to correctly interpret d-oct decreases with increasing experience in the scanning procedure. * delineation of periocular bcc tumour extension is possible using both d-oct probes


Eligibility criteria:
inclusion criteria: * clinically suspected periocular bcc. * biopsy-verified bcc * clinically suspected relapse of periocular bcc * age more than 18 years at baseline. * legally competent, able to give verbal and written consent * communicate in danish verbally as well as in writing * willingness to participate and able to give informed consent and can comply with protocol requirements. exclusion criteria: * anatomical circumstances that make oct-scanning impossible, i.e., extensive scarring of eyelids, or large ulcerating crusts that hampers scanning * unwillingness to undergo a skin biopsy or excision of lesion. * inability to sign informed consent.

Keywords: carcinoma, basal cell* / diagnostic imaging carcinoma, basal cell* / pathology carcinoma, basal cell* / surgery neoplasm, glandular and epithelial skin neoplasm diagnostic imaging sensitivity and specificity tomography, optical coherence* / methods skin neoplasm* / surgery neoplasm recurrence eyelids / pathology skin diseases periocular bcc
a phase 2 efficacy study of cls003 icvt in subjects with cutaneous warts.

Conditions: Cutaneous Warts

Summary: a phase 2, randomized, vehicle-controlled, double-blind study to assess the efficacy, safety and pharmacodynamics (pd) of topically applied cls003 in otherwise healthy patients with cutaneous warts.


Eligibility criteria:
inclusion criteria: * absence of evidence of any active or chronic disease; * free of clinical significant systemic or dermatologic disorder, which, in the opinion of the investigator, will interfere with the study results or increase the risk of adverse events; * have at least 2 (non-subungual) common warts or at least 2 plantar warts on non-genital, nonfacial skin exclusion criteria: * any clinically significant abnormality that in the opinion of the investigator would interfere with the study objectives or compromise subject safety; * for women: a positive pregnancy test and/or nursing at screening or women who plan to become pregnant or are breastfeeding; * a positive test for drugs of abuse at screening; * history of alcohol or illicit drug abuse (alcohol abuse defined as alcohol consumption \> 28 units/week); * positive test results for hepatitis b, hepatitis c or hiv; * have used salicylic acid or any other over-the-counter wart-removing product in the treatment area within 30 days prior to starting the study or cryotherapy within 60 days of starting the study; * have required systemic intake of immunosuppressive or immunomodulatory medication (including oral or parenteral corticosteroids) within 30 days prior to enrollment or during the course of the study. routine use of inhaled or intranasal corticosteroids during the study is allowed; * have a known sensitivity to any of the investigational product ingredients * clinically relevant abnormal laboratory results, ecg, vital signs, or physical findings at screening; * participation in an investigational drug or device study within 3 months prior to screening or more than 4 times in the past year;
ziagen® post-marketing surveillance

Conditions: Infection, Human Immunodeficiency Virus I

Summary: an open label, multi-centre, non-interventional post-marketing surveillance (pms) to monitor the safety and efficacy of ziagen® administered in korean patients according to the prescribing information.

this study will collect clinical data, mainly focused on safety, in korean population as per the requirement of kfda for market authorization. viiv healthcare is the new sponsor of this study, and glaxosmithkline is in the process of updating systems to reflect the change in sponsorship.

Eligibility criteria:
all subjects must satisfy the following criteria. * subject who is treated in combination with other antiretroviral agents for the treatment of hiv infection. * subject who is considered to follow this post marketing surveillance protocol by the investigator. * subject who is treated with ziagen® according to the prescribing information. as considering the characteristic of observational post marketing surveillance, the exclusion criteria is not strict. all investigators should prescribe ziagen® according to the prescribing information which approved in korea. * subjects with hypersensitivity to ziagen® or ingredients * subjects with moderate or severe hepatic impairment * subject with end-stage renal disease

Keywords: abacavir post-marketing surveillance
factors influencing readmission rates of acute traumatic subdural hematoma in the elderly

Conditions: Traumatic Subdural Hematoma

Summary: acute traumatic subdural hematomas (tsdh) readmission rate is high (27.8%) with an increase in morbidity and cost for the elderly. this study identifies risk factors affecting readmission rates for these patients and presents strategies to reduce it.

a retrospective analysis was conducted on patients with traumatic brain injuries (icd-9-cm codes 800.20 - 801.86, 852.00 - 853.05) admitted between 2014 and 2016 at genesys regional medical center through the trauma service. from this group, the investigators selected patients admitted with traumatic sdh, and those patients were followed over the following 6 months as regards to readmission status. patients who were readmitted versus patients who were not readmitted were compared. the risk of readmission within 6 months of discharge for sdh was analyzed adjusting for age, prior anticoagulation use, injury severity score (iss), glasgow coma scale (gcs), gender, time to readmission and co-morbid conditions which included diabetes mellitus, cardiovascular disease, renal disease, chronic obstructive pulmonary disease, and osteoporotic/orthopedic fractures using cox proportional hazards regression analysis.

Eligibility criteria:
inclusion criteria: * patients diagnosed with traumatic subdural hematoma during time of study exclusion criteria: * patients who expired.

Keywords: subdural hematoma readmission risk factors
virtual reality during conization of cervix uterus under local anesthesia

Conditions: Dysplasia, Cervix

Summary: to evaluate the effectiveness of virtual reality glasses as a distraction technique in the management of acute pain and anxiety during conization of cervix uterus under local anesthesia

a prospective, open-label, randomized control trial in a tertiary university affiliated medical center between march 2021 to march 2023. overall, 100 women referred for conization of cervix due to cervical dysplasia will be randomly allocated to undergo conization either with the use of virtual reality glasses (study group) or with standard treatment (control group). the primary outcome measures will include self-reported pain, anxiety scores, and vital signs as an indirect measurement of pain and anxiety, including pulse rate (pr) and respiratory rate (rr). pain and anxiety outcomes will be measured as numeric rating scores.

Eligibility criteria:
inclusion criteria: patients over 18 years referred for conization of cervix due to cervical dysplasia exclusion criteria: * patients under 18 years * pregnant women

Keywords: cervical dysplasia; conization; anxiety; pain; virtual reality
treatment of overweight and obese children -using the "holbaek-method" in a municipality based treatment program.

Conditions: Pediatric Obesity; Dyslipidemia; Hypertension; Diabetes; Quality of Life

Summary: in the present study the effect of a community-based treatment of overweight and obese children is analyzed. the treatment-method is based on the principals and the method used in the children obesity clinic in the pediatric department i holbaek. the effect is evaluated by the change in body mass index standard deviation score, change in blood pressure standard deviation score, quality of life and concentration of fasting blood lipids and glucose during one year of treatment.

in the present study the effect of a community-based treatment of overweight and obese children is analyzed. the treatment-method is based on the principals and the method used in the children obesity clinic in the pediatric department i holbaek and the care providers in each of the eight municipalities included are thought thoroughly to use this method. the treatment effect is evaluated after one year, and the effect is assessed by the change in body mass index standard deviation score, change in blood pressure standard deviation score, quality of life (pedsql), body composition and concentration of fasting blood lipids and glucose.

Eligibility criteria:
inclusion criteria: - body mass index above 90-percentile for age and gender exclusion criteria: * none

Keywords: pediatric obesity community-based treatment dyslipidemia hypertension diabetes
preoperative melatonin to decrease analgesia usage after third molar surgery

Conditions: Pain, Postoperative; Narcotic Use

Summary: the purpose of the study is to assess if melatonin given for three nights before wisdom tooth surgery decreases post-operative pain and pain medication consumption. patients will receive either melatonin or a placebo for three nights prior to surgery and we will measure pre-operative anxiety, preoperative sleep quality, post op pain medication consumption, post op pain scores, and blood values.


Eligibility criteria:
inclusion criteria: * subject must have 3-4 partial or full bony impacted third molars requiring surgical extraction under iv sedation * ages 18-35 * asa class i or ii * english or spanish speaking patients * capacity to sign informed consent exclusion criteria: * allergies to melatonin, opioids, or other otc pain medications * anyone currently taking melatonin for any reason * cases under local anesthesia * asa class iii or higher * sleep disorder (insomnia/narcolepsy) * current or past history of substance abuse * chronic pain * language/communication barrier * psychiatric disease/ mental impairment * current or past use of psychotropic drugs * pregnancy * renal or hepatic impairment * bmi \>35
effects of bupivacaine and levobupivacaine on cerebral oxygenation during intrathecal anesthesia in elderly patients

Conditions: Complication of Anesthesia

Summary: elderly patients with hip fracture are frail due to associated comorbidity. in these situations, regional anesthesia is recommended as it is associated to less postoperative cognitive dysfunction. however, hypotension during the process may impair ischemic cardiopathy and induce a cerebrovascular stroke. selection of the right anesthetic agent and the administration of vasoactive drugs during the process can minimize these risks. although bupivacaine and levobupivacaine share pharmacokinetic and pharmacodynamic properties, the studies show conflicting results. the aim of this study is to investigate if there are clinically relevant differences between these two drugs in terms of hemodynamic parameters during the surgical process with special focus on the effects on regional cerebral oximetry and cognitive status after surgery.


Eligibility criteria:
inclusion criteria: 1. patients older than 70 years old who undergo major surgery for hip fracture and will receive intrathecal anesthesia 2. patients in which it is considered adequate, according to the usual clinical practice, the use of bupivacaine or levobupivacaine as part of the intrathecal anesthesia 3. patients who give their informed consent to participate in the study exclusion criteria: 1. patients allergic to anesthetic drugs to be used in the protocol or to local anesthetics amida type. 2. patients with severe aortic stenosis or hemodynamic instability. 3. patients who refuse the anesthetic technique or contraindication for the use of the intrathecal technique. 4. patients with severe cognitive impairment previous to the intervention (defined by a score in the pfeiffer test of 8-10 errors) 5. patients in which the use of bupivacaine or levobupivacaine is contraindicated as part of the intrathecal anesthesia 6. any condition that, in the investigator's opinion, could pose a risk to the patient

Keywords: intrathecal anesthesia levobupivacaine bupivacaine hip fracture
french observatory of rare malignant tumors of the ovary

Conditions: Ovarian Tumors

Summary: to take charge of the treatment in rare adult ovarian tumors with an homogenous manner (germinal and sexual cords tumors), at different stages of the disease.

* to establish prognosis factors for the disease * to proceed in a centralised examination of histologic laminas * to reach in the long-term and homogenous follow-up of the patients * to follow-up the long-term toxicities of the treatments given * to analyse and follow-up the later fertility of the patients * to evaluate the interest of setting a multi-disciplinary discussion forum on the web

Eligibility criteria:
inclusion criteria: * age \> 18 years old * germinal or sexual cords ovary tumors histologically proven * first line or relapse treatment * written informed consent exclusion criteria: * mental ineptitude to understand and follow the study

Keywords: ovarian tumors rare ovarian tumors germinal tumors sexual cords tumors observatory forum
effect of ad128 to treat obstructive sleep apnea

Conditions: Sleep Apnea, Obstructive

Summary: this study evaluates the combination of two drugs (ad128), to treat obstructive sleep apnea (osa) severity. after a baseline evaluation and during 7 days, half of the participants will randomly receive this drug combination (ad128) and the other will receive a placebo, i.e. a drug without pharmaceutical effect. neither the participants, nor the investigators will know in which arm participants are until the end of the study. after one week of trial, an evaluation will be perform and will be follow by one week without any treatment. during the third and last week of trial, there will be a crossover of the groups, i.e. the participants of the first group who took the two drugs (ad128) during the first week will take a placebo and those who took the placebo will take the drugs combination.


Eligibility criteria:
inclusion criteria: * adults (\>18 years and ≤ 65 years) * new or previous diagnosis of osa with an ahi \> 15/h on a polygraphic or polysomnographic recording (participants already treated with continuous positive airway pressure (cpap) or mandibular advancement device can be included but a 7-days wash-out period is required before the beginning of the protocol and cpap usage will not be possible during the whole protocol duration), * informed consent as documented by signature (appendix informed consent form) exclusion criteria: * history of seizures, * history of glaucoma, * history of benign prostatic hyperplasia, organic miction disorder or urinary retention, * gastrointestinal disease (e.g. stenosis, occlusion, ulcerative colitis, toxic megacolon, hiatal hernia...) * cardiac arrhythmia, * history of bipolar disorder, * use of respiratory stimulants or depressants, * use of hypnotics, * use of central nervous system stimulants, * use of monoamine oxidase inhibitors (maois) antidepressant, * major depressive disorder, * central sleep apnea representing more than 10% of all respiratory events * contraindications to the class of drugs under study, e.g. known hypersensitivity or allergy to class of drugs or the investigational product, * pregnant or breast feeding female participants or participants who intend to become pregnant during the study (however, there is no contraindication to contraception), * other clinically significant concomitant disease states (renal failure, hepatic dysfunction, severe cardiovascular or respiratory disease, myasthenia gravis, cerebral sclerosis), * known or suspected non-compliance, drug or alcohol abuse, * inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant, * participation in another study with investigational drug within the 30 days preceding and during the present study * use or morphinic and derivatives which may influence sleep, * refusal to be informed in case of incidental findings.

Keywords: obstructive sleep apnea pharmacologic treatment sleepiness vigilance