Kornimate/medical-research-clean huggingface dataset:
interval training in bipolar disorder

Conditions: Bipolar Disorder

Summary: our main objective will be to evaluate the chronic effects (12 weeks) of high-intensity interval training compared to moderate intensity (same total work) on reducing the symptoms of bipolar disorder, cortical changes, as well as on the vo2max. in addition, the investigators will establish what influence of gain to vo2max has on reducing symptoms.

physical exercise has significant effects on health promotion and the consequent reduction of the severity of bipolar disorder (bd). this review establishes a pattern of response of exercise and potential impact on the pathophysiology of bd; , as well as, produces hypotheses on how acute and chronic effect of exercises may act differently; and provides future perspectives with the focus of the exercise as an important and innovative model of treatment for bd and mental disorder. a critical evaluation of the literature was undertaken including the influence of exercise on health promotion in patients with mental disorders, neurochemical behavior exercise-induced, as well as reflective introduction of news perspectives of training control in severe exercise domain. the exercise induces significant changes in monoaminergic after, and with long-term training, and work with a threshold of exercise can modulate positive effects on mood. fast adaptive effects from the high intensity interval training should be considered in bd patients. however, there must be caution in his administration. we speculate that exercise may be a way of maintaining euthymia in the case of bd, making it less vulnerable patient to stay longer at a time of neutrality. future research is needed to adopt a training strategy that is both time efficient in the different areas and adequate for the population in question.

Eligibility criteria:
inclusion criteria: * bipolar criteria (dsm-iv), * sedentary lifestyle exclusion criteria: * 60 and over, * cardiovascular disease, * panic disorder, * metabolic syndrome diagnosis

Keywords: bipolar disorder vo2max aerobic exercise
efficacy of a brain-computer interface controlled functional electrical stimulation therapy for spinal cord injury neurorehabilitation

Conditions: Cervical Spinal Cord Injury

Summary: the study's main goal is to determine the efficacy of a therapy with brain-computer interface controlled functional electrical stimulation for neurorehabilitation of spinal cord injury patients' upper limbs. for this purpose, a randomized controlled trial will be performed to compare the clinical and physiological effects of the brain-computer interface therapy with those of a sham intervention comprised by the application of functional electrical stimulation independently of brain-computer interface control.


Eligibility criteria:
inclusion criteria: * spinal cord injury at neurological levels c6 or c7 * american spinal injury association (asia) classification a, b, c or d * upper limb spasticity of less or equal to +1 measured with the modified ashworth scale * time since disease onset of more than 6 months and less than 60 months * normal or corrected to normal vision exclusion criteria: * severe attention deficits * previous diagnosis of traumatic brain injury * previous diagnosis of peripheral nerve injury * previous stroke diagnosis * previous diagnosis of neurodegenerative diseases * history of fractures in upper extremities * skin lesions * contractures in upper extremities that hamper mobility * excessive muscle spasms

Keywords: brain-computer interface functional electrical stimulation motor rehabilitation tetraplegia
real-time interactive digital healthcare system in frozen shoulder; randomized controlled trial

Conditions: Frozen Shoulder

Summary: this study aims to examine the effect of hospital-home linkage short-term rehabilitation therapy using real-time interactive digital healthcare system (uincare homeplus) in frozen shoulder. this is prospective randomized controlled trial and multi-center study. 100 frozen shoulder who diagnosed with limited range of motion in 2 more plane of flexion, abduction, external rotation of affected shoulder. shoulder range of motion (rom), shoulder pain and disability index (spadi), pain evaluation with numeral rating scale (nrs), quality of life evaluation with short form (sf)-36 health survey and eq-5d-5l, activity daily living (adl) evaluation with canadian occupational performance measure (copm) will be evaluated on enrollment, 4-week, 8-week, 12-weeks, 18-weeks, and 24 weeks after enrollment.

the frozen shoulder is a disease in which severe pain and limited range of motion of the shoulder occur as an inflammatory change occurs in the articular capsular surrounding the shoulder joint. as a result, it has caused limitation in daily life movement. uincare homeplus is software manufactured in korea, which uses infrared, kinect camera and motion capture technology to track 3d motion of the patients' articulation. using this technology, the patients can receive feedback of their motion immediately. the objective of the study is to examine the effect of hospital-home linkage short-term rehabilitation therapy using real-time interactive digital healthcare system (uincare homeplus) in frozen shoulder.

Eligibility criteria:
inclusion criteria: * limited passive range of motion of the affected shoulder in 2 more plane (flexion \< 150˚, abduction \<150˚, external rotation \< 60˚) exclusion criteria: * bilateral frozen shoulder * secondary frozen shoulder caused by trauma (shoulder fracture, dislocation), or/and inflammatory disease(rheumatoid arthritis) * those unable to perform exercise due to general deconditioning * those with communication difficulty
intravascular ultrasound-guided pci in patients with st-elevation myocardial infarction

Conditions: STEMI; Intravascular Imaging; IVUS

Summary: the main goal of the ultra-stemi trial is to investigate the prognostic impact of ivus-guided pci in patients with stemi and correlate ivus measurements with clinical, procedural, imaging and follow-up outcomes of interest. study participants will undergo primary pci as per standardized procedures; ivus will be performed at baseline, post-intervention and post-optimization. manual thrombus aspiration will be performed according to clinical indications. the aspirated thrombi will be collected and scanned with micro-computed tomography (micro-ct). also, angiographic and peri-procedural data will be gathered. post-pci instantaneous wave-free ratio (ifr) will also be performed to assess the severity of the residual coronary-artery stenosis, if any. all patients will be followed up for at least12 months for the adjudication of major adverse cardiovascular events.

the ultra-stemi trial is a prospective investigator-initiated single-centre single-arm observational cohort study aiming to enroll 80 consecutive patients presenting with st-segment elevation myocardial infarction (stemi) and undergoing ivus-guided primary pci. ivus will be performed at baseline, post-intervention and post-optimization. baseline tissue characterization includes the morphological description of culprit lesion plaque and thrombus characteristics as assessed with ivus. in patients with large thrombus burden, manual thrombus aspiration will be performed according to clinical indications. the aspirated thrombi will be collected and scanned with micro-computed tomography (micro-ct) to correlate ivus measurements with micro-ct thrombus quantification. also, angiographic data will be gathered to correlate ivus measurements with pre-and post-pci angiographic information. post-pci instantaneous wave-free ratio (ifr) will also be performed to assess the severity of the residual coronary-artery stenosis, if any. all patients will be followed up for at least 12 months for the adjudication of major adverse cardiovascular events.the primary endpoint will be target vessel failure at 12 months (defined as a composite of cardiac death, target vessel myocardial infarction and clinically driven target vessel revascularization). the secondary outcomes of interest will be: radiation exposure, contrast use and kidney function effects. other endpoints include clinical and angiographic outcomes along with post-pci ivus, ifr and micro-ct findings.

Eligibility criteria:
inclusion criteria: 1. patients with acute stemi undergoing primary pci within 12 hours of symptom onset according to the 4th universal definition of myocardial infarction. 2. age \>18 years 3. individuals willing to voluntarily sign the consent and data protection forms before their inclusion in the clinical study. exclusion criteria: 1. patients presenting with cardiogenic shock 2. patients with a known contraindication for primary pci 3. pregnancy 4. presentation ≥12 hours after symptom onset

Keywords: ivus thrombus stemi
xenogenic collagen matrix and subepithelial connective tissue graft in the treatment of gingival recession

Conditions: Gingival Recession Localized Moderate

Summary: this study is a clinical evaluation of using xenogenic collagen matrix (xcm) plus coronally advanced flap (caf) compared to subepithelial connective tissue graft (sctg) plus coronally advanced flap to treat miller class i gingival recession. a split-full-split thickness flap will be elevated in the (xcm+caf) group while it will be an only partial thickness flap in the (sctg+caf) group. the sample size will be 15 patients. each patient has bilateral miller class i gingival recessions; and as a split-mouth study design one side will be treated with (sctg+caf), while the other will be treated with (xcm+caf).

the aim of this study is to clinically compare between the subepithelial connective tissue graft (sctg) plus coronally advanced flap (caf) which is defined as the golden standard for the treatment of gingival recessions and xenogenic collagen matrix (xcm) plus coronally advanced flap (caf) to treat class i miller gingival recession. caf elevation will be done as it described by (de sanctis \& zucchelli 2007) with modifications in the the control group.the flap will be partially elevated in the (sctg+caf) group while it will be a split-full-split thickness flap in the (xcm+caf) group, and finally the flap will stabilized coronally. fifteen patients who have bilateral buccal miller class i gingival recession defects will be enrolled in this study. these defects will be distributed randomly into two groups: the test group (xcm+caf) and control group (sctg+caf). clinical parameters will be evaluated: recession depth (rec), change in visible plaque index, recession width (rw), width of keratinized tissue (kt), thickness of gingival tissue (gt), probing depth (pd), clinical attachment level (cal), healing index (hi), questionnaires will be given to evaluate each of patient perceptions, pain index (pi), and changes in root sensitivity by using visual analog scale (vas).

Eligibility criteria:
inclusion criteria: * good general health. * no contraindications for periodontal surgery. * presence of one localized gingival recession in each side of the maxilla and/or mandible, all recessions will be class i defects (miller 1985). * the cemento-enamel junction (cej) is visible in the defective teeth. * all patients demonstrating good plaque control. * no previous periodontal surgery in the targeted area. exclusion criteria: * smokers. * pregnant or nursing patients. * history of malignancy, radiotherapy, or chemotherapy. * patients taking medications that affect mucosal healing. * patients with allergy to collagen. * previous participation in a clinical trial. * type-1 diabetes patients. * patient who have diseases that affect connective tissue metabolism.

Keywords: xenogenic collagen matrix (xcm). subepithelial connective tissue graft (scgt). coronally advanced flap (caf). root coverage.
the real-world firebird 2 versus cypher sirolimus-eluting stent in treating patients with coronary artery disease

Conditions: Coronary Artery Stenosis

Summary: sirolimus-eluting stent (ses) has been world-widely used in clinical practice in treating patients with coronary artery disease (cad). the efficacy and safety of cypher ses (cordis, ma) has been proved by several randomized clinical trials. here the investigators design a prospective, multicenter, randomized clinical study in purpose of identifying the non-inferiority in the efficacy and safety in treating cad patients by firebird 2 ses (microport, shanghai), comparing with cypher ses.


Eligibility criteria:
inclusion criteria: * age \> 18 years * male or un-preganant female * stenosis \> 70% in one of major the epicardial coronary arteries * no contra-indications of stent implantation * singed the informed consent exclusion criteria: * acute myocardial infarction within one week * have contra-indications of stent implantation or can not tolerate dual antiplatelet therapy * no history of stent implantation within last one-year * received other brand coronary stent during index procedure * with no achievement of informed consent

Keywords: significant stenosis (>70% of lumen stenosis) epicardial coronary arteries.
the effect of preoperative anxiety, on gastric antrum size in women undergoing in vitro fertilization

Conditions: Ultrasonography

Summary: pulmonary aspiration is one of the most serious risks of general anesthesia and has been reported to occur in as many as 1 in 4000 cases of general anesthesia. gastric ultrasound is an emerging point-of-care tool that provides bedside information on gastric content and volume. there have been a few factors which are thought to increase gastric size. delayed gastric emptying such as caused by gastroparesis in diabetes mellitus is an example. certain surgeries also cause gastroparesis. other preoperative factors including pain, preoperative anxiety, and blood levels of estradiol or progesterone are less well studied.

women will be recruited before undergoing the procedure. upon signed informed consent, women will be asked to rank their anxiety level on a scale of 0-10 (verbal numeric anxiety score). this scale has been used for previous studies to assess anxiety (orbach-zinger, danon) in the operating room, a gastric ultrasound will be performed in the supine position and the antral cross sectional area will be measured. this study is purely observational, the gastric ultrasound assessment is non-invasive and will not cause any adverse effects or discomfort to the patient. participation in the study will not affect clinical management in any way. each one of the ultrasound assessments will be performed by one of the study's' investigators. anesthesia will be induced in standard procedure and positive pressure will be instituted according to the standard protocol accepted in our hospital. at the end of the procedure, the gastric ultrasound circumference will be measured again.

Eligibility criteria:
inclusion criteria: woman aged 18 and above undergoing general anesthesia for oocyte retrieval during in vitro fertilization with the ability to sign an informed consent. exclusion criteria: 1. women with bmi \>40 2. women with diabetes 3. women who have previously undergone gastric surgery 4. women with language barriers.
konvert-af - relevance of point in time for conversion of acute atrial fibrillation

Conditions: Atrial Fibrillation

Summary: to investigate if in acute symptomatic atrial fibrillation (af) the early (\>2 hrs but within 12 hrs of the beginning of the arrhythmia) electrical cardioversion leads to a longer recurrence-free interval than the delayed cardioversion (\> 36 hrs but \< 48 hrs after the beginning of the arrhythmia) within the first 3 months after cardioversion.

so far it is unknown if early or delayed cardioversion is most beneficial for patient outcome and which strategy is best to prevent recurrence of af. the konvert-af trial investigates if in acute symptomatic af the early (\>2 hrs but within 12 hrs of the beginning of the arrhythmia) electrical cardioversion leads to a longer recurrence-free interval than the delayed cardioversion (\> 36 hrs but \< 48 hrs after the beginning of the arrhythmia) within the first 3 months after cardioversion. primary endpoint is the time to the first recurrence of af. the konvert-af trial will be conducted as prospective, randomized, non-blinded multicentre study. it is planned to include 380 patients in 10-20 recruitment centres.

Eligibility criteria:
inclusion criteria: * documented af that began between 2 and 8 hrs before randomization * indication for electrical cardioversion. * age above 18 yrs * written informed consent exclusion criteria: * af caused by not adequately treated reversible conditions(e.g. myocardial infarction, thyrotoxicosis, ethanol intoxication, infection, pericarditis, surgery) * newly initiated (i.e. within 7 days before randomization) antiarrhythmic agents of class i, ii and/or iii * catheter ablation of af within 3 months before randomization * pacemaker or icd * myocardial infarction within 3 months before randomization * urgent need to cardioversion of af because of associated potentially dangerous symptoms such as chest pain, syncope, dyspnea * contraindications for therapy with vitamin k-antagonists * intracardial thrombus * primary indication for pharmacological cardioversion * in females: pregnancy, lactation period or no sufficient contraception within last 3 months

Keywords: atrial fibrillation early cardioversion electrical cardioversion
tamibarotene and arsenic trioxide for relapsed acute promyelocytic leukemia

Conditions: Acute Promyelocytic Leukemia

Summary: subjects have acute promyelocytic leukemia (apl) that has come back (relapsed) after initial treatment or has not gone away with initial therapy. this research study involves testing an investigational drug called tamibarotene in combination with standard treatment for relapsed apl called arsenic trioxide. tamibarotene has been approved in japan to treat patients with relapsed apl since april 2005. tamibarotene is in the same family of drugs as all-trans retinoic acid (atra), a medication that subjects received previously in their treatment. atra and tamibarotene both cause the apl cells to differentiate (or become) normal non-leukemia cells. laboratory studies of tamibarotene have shown to be effective in apl. the purpose of this study is to determine if tamibarotene in combination with arsenic trioxide is safe and effective.


Eligibility criteria:
inclusion criteria: * must have diagnosis of relapsed apl * must have completed any prior cancer treatment at least 6 months prior to study * must have had prior treatment that included atra
effect of a physical exercise intervention based on the transtheoretical model on blood pressure

Conditions: Hypertension

Summary: background: hypertension is a public health problem; the world health organization (who) estimates that more than 1280 million people suffer it. the treatment of said condition is pharmacological and non-pharmacological. physical activity is part of the treatment, but unfortunately few adults can be classified as physically active. there is evidence that performing physical exercise reduces systolic blood pressure by up to 5 mm hg, which has associated with reduced heart disease by up to 9%, ictus up to 14% and all-cause mortality by 4%. lifestyle changing interventions, among them promoting exercise marked by a theory of behavior change, have shown positive results. objective: to evaluate the effect of an intervention promoting the performance of physical exercise, with specific recommendations, based on the transtheoretical model, on systolic blood pressure and on the amount of exercise performed (minutes/week) in patients with hypertension aged 40 to 70 years, users of primary care in the mexican institute for social security (imss) in aguascalientes. material and methods: randomized clinical trial, in which 442 patients with hypertension will participate. the control group will receive conventional care and recommendations for physical exercise and diet. the intervention group, in addition, will attend 6 workshops, one a month, which will promote performing physical exercise, with access given to videos of physical exercise routines, designed to gradually increase the exercise performed. at the start and end of the study, blood pressure, anthropometric measurements will be taken, through a questionnaire asking about sociodemographic data, performance of physical exercise, psychosocial factors regarding physical exercise, diet and adherence to pharmacological treatment. the characteristics of the study population by group will be described, and changes between baseline and final measurements compared, intra and intergroup, in the systolic blood pressure and minutes/week of physical exercise.


Eligibility criteria:
inclusion criteria: * patients with hypertension. * patients from 40 to 70 years old. * imss primary care users at umf no. 1, in aguascalientes. * patients who agree to participate in the study. exclusion criteria: * patients with hypertension that have a medical contraindication for performing physical exercise, or whose health status suggests an individualized, supervised exercise plan (angina, arrhythmia, chronic kidney disease, lupus erythematosus). * patients who have some mental alteration that impedes answering the questionnaires or adequately following the established strategy.

Keywords: physical exercise transtheoretical model lifestyle
telerehabilitation in managing chronic low back pain

Conditions: Low Back Pain (LBP)

Summary: the purpose of this study is to determine whether telerehabilitation is as effective as in-person rehabilitation in treating patients with chronic back pain in actual clinical practice settings.t he study will recruit eighty-four individuals with chronic lbp, who will be randomly assigned to one of two groups: telerehabilitation (tr) or the control group, who will receive standard clinic therapy. the tr group will be treated remotely via phone calls and the zoom platform. the intervention program will be customized according to the requirements and abilities of each patient. it will include self-management skills, education and support, including pain neuroscience education , and customized exercises.


Eligibility criteria:
inclusion criteria: adults aged 18 and above with non-specific chronic low back pain more than 12 weeks. exclusion criteria: cancer, systematic or neurological diseases, fracture, recent surgery on the spine and/or extremities, cognitive impairment, pregnant women, and communication barriers or other medical conditions contraindicating tr. if there is any presence of red flags, such as cauda equina syndrome, spinal infection, spinal compression fractures, spinal stress fractures, ankylosing spondylitis, or aneurysm will also be excluded.