Kornimate/medical-research-clean huggingface dataset:
effectiveness of multiple robotic gait-devices for improving walking ability in subacute stroke patients

Conditions: Gait Disorders, Neurologic; Stroke; Walking

Summary: the purpose of this study is to know the effectiveness of different robotic devices for gait rehabilitation in stroke patients

subjects will attend the neuron rehabilitation clinic on their own to begin a rehabilitation program. after being recruited for the study and signing informed consent the patient will be assessed with the timed up and go test and 10 meter walking test, and it will be realized a spatio temporal variables analysis with baiobit system and a superficial electomiografic activity analysis during gait with noraxon system. once the assessment is completed, the participant will receive the treatment assigned at his rehabilitation clinic. the patient will receive 30 minutes of robotic treatment with lexi, lokomat, c-mill or the body-weight support treadmill and 15 minutes of overground walking training between 70-85% of hr max. once the treatment period is over, after 25 sessions, the assessment will be carried out again, recording the initial tests in the same order by the same assessors.

Eligibility criteria:
inclusion criteria: * having suffered an ischaemic or haemorrhagic stroke with less than 6 months of evolution at the start of the study * presenting gait deficits compatible with a level between 2 and 3 of the functional category of gait (fac) * more than 20 seconds in the time up and go test * less than 3 points on the reisberg global deterioration scale (gds-r). exclusion criteria: * presenting any type of specific contraindication to use the robotic device to be used with respect to their group. thus, those patients who present a limitation in the range of movement in the hip of more than 0º of extension and 40º of flexion, in the knee of less than 30º of flexion and in the ankle of less than 0º of dorsal flexion will not be able to participate in the study. * lower limb spasticity greater than 3 on the modified asworth scale * unable to maintain an assisted standing position for more than 5 minutes * unable to understand simple commands

Keywords: gait-devices robotics stroke gait
milestones of adjustment post-psychosis

Conditions: Schizophrenia; Quality of Life; Adjustment, Psychological; Medication Adherence; Signs and Symptoms

Summary: this nested design clinical outcome study of psychiatric case manager education on disease state, psychopharmacology of schizophrenia, relapse, motivational interviewing, and the process of psychological adjustment post-psychosis (milestones of adjustment post-psychosis recovery model-mapp) will test the following hypotheses: 1. medication non-adherence in patients with schizophrenia assigned to case managers who receive mapp training will decrease from their pre-study rate and from the reported national average after one year enrollment compared to consumers not enrolled in the mapp arm of the study. 2. consumers in the mapp intervention will have higher quality of life enjoyment and satisfaction questionnaire (q-les-q (53) scores than consumers not enrolled in the mapp at quarterly measures. 3. consumers enrolled in the mapp intervention arm of the study will successfully complete the first two phases of the mapp recovery model in one year. 4. consumers in the mapp intervention arm will have greater symptom reductions at quarterly data points compared to consumers not enrolled in the mapp intervention arm.

52 psychiatric case managers will receive manualized training in the disease state of schizophrenia, psychotropic medications, motivational interviewing, and relapse prevention. after randomization, 26 case managers will receive additional manualized training in the process of post-psychotic adjustment. outcomes of 130 consumers (5 per case manager) related to medication adherence, relapse rates, symptom intensity, and quality of life will be evaluated at quarterly intervals over a two-year period. outcomes of 130 consumers related to medication adherence, relapse rates, symptom intensity, quality of life, and progression through the phases of postpsychotic adjustment (mapp-milestones of adjustment post-psychosis recovery model) will be evaluated at quarterly intervals via rating scales over a two-year period and the two groups compared.

Eligibility criteria:
inclusion criteria:case managers * voluntary basis-includes willingness to administer study tools quarterly for two years to at least five consumers from their assigned caseloads and to keep a log of their activities and reactions. inclusion criteria for consumer subjects: 130 in each treatment arm 1. a diagnosis of a schizophrenia spectrum disorder as defined by dsmiv tr (63) 2. males and females at least 21 years of age assigned to case managers 3. able to understand the requirements of the study exclusion criteria:case managers * none, all case managers are eligible for the study exclusion criteria: consumers * any dsm-iv axis i disorder not defined in the inclusion criteria

Keywords: symptom management empowerment medication adherence recovery schizophrenia post-psychotic adjustment process psychological adjustment psychiatric case managers psychosis insight cognitive function
cognitive training for fragile x syndrome

Conditions: Fragile X Syndrome

Summary: individuals with fragile x syndrome (fxs) demonstrate profound executive function deficits that interfere with learning, socialization and emotion regulation. extensive research focused on the animal models of fxs show that targeted pharmacological agents can normalize synaptic connectivity and reverse cognitive and behavioral deficits. this translational work has led to multiple national and international controlled trials in humans with fxs now underway. however, in contrast to the heavy focus on medication treatments, there have been no controlled trials to empirically-validate cognitive or behavioral interventions for fxs. the proposed study, the first non-pharmacological controlled trial for fxs, will evaluate the efficacy of cogmed, a cognitive training program proven to enhance working memory and executive/frontal function in a variety of clinical populations. demonstration of effective cogmed training for fxs would represent a major advance in the field, one that may also generalize to other forms of intellectual disability. furthermore, it is critical to determine whether the targeted pharmacological treatments can accelerate learning and cognitive development. thus, the validation of cogmed for fxs will provide a paradigm for testing hypotheses focused on combined efficacy of medication and cognitive training.


Eligibility criteria:
inclusion criteria: * fragile x full mutation * normal or corrected vision * english or spanish speaking * ability to pass three-span items following completion of a cogmed training session at baseline * parental agreement to maintain adherence to the training schedule and to not alter other treatments during the study unless medically necessary exclusion criteria: * previous cogmed training * significant medical problems that would interfere with the study or significant brain trauma
feasibility bowel dysfunction program after low anterior resection

Conditions: Rectal Cancer; Low Anterior Resection

Summary: this study will facilitate a better understanding of the overall experience of our rectal cancer survivors after low anterior resection for rectal cancer. studies have demonstrated that the development of bowel and genitourinary dysfunction after this procedure is very distressing to patients and can have a significant impact on overall quality of life. by providing interventions that can be performed at home, investigator may alleviate these symptoms in hopes of improving the experience of patients undergoing low anterior resection. by acknowledging these potentially debilitating symptoms in a systematic way, the investigator hopes to reinforce the importance of symptom management in the survivorship phase after treatment has been completed and ultimately facilitate an individual's return to routine activities.

subjects will be recruited from patients presenting to the surgical oncology clinic at fox chase cancer center. these patients will have already undergone low anterior resection with a diverting stoma (colostomy or ileostomy) and will be planning on undergoing reversal of their stoma in the near future. subjects will be recruited over a period of 1 year. such clinic patients' medical records will be reviewed to determine whether they are possible candidates for inclusion in the study. they will be identified based on their diagnosis of either stage ii or iii rectal cancer as stated in prior clinic notes, pathology reports, or radiologic image reports. participants must have previously undergone low anterior resection with a diverting stoma and the surgical plan must be for them to undergo ostomy reversal. they will be approached during a clinic visit by either a co-investigator or a member of the surgery team (fellow or surgeon) or a research coordinator delegate and asked to participate in the research study. they will be given a document for informed consent that will describe the study and potential risks and benefits to the patient. the investigators plan to enroll 10 patients at fox chase cancer center. subjects will receive no monetary compensation

Eligibility criteria:
inclusion criteria: * diagnosis of stage ii or iii rectal cancer, a history of having an lar with diverting stoma, and a plan to undergo stoma reversal within the next 6 months exclusion criteria: * patients enrolled who develop an anastomotic leak at the time of stoma reversal that would necessitate another temporary or permanent stoma, they will be considered unevaluable and will be excluded from the analysis

Keywords: bowel dysfunction low anterior resection rectal cancer
collagen markers in heart failure and preserved ejection fraction

Conditions: Left-sided Congestive Heart Failure

Summary: assessment of cardiac fibrosis by echocardiography (speckle tracking), irm (late-enhancement imaging), biology (markers of collagen turn-over) and proteomics

heart failure (hf) is a growing public health problem. while hf with deteriorated ejection fraction has faced numbers of (non) pharmacological advances, hf with preserved ejection fraction, which represents half of admission has today no efficient treatment. fibrosis is found in heart of patients with hf and preserved ejection fraction, is reponsible for stiff heart and has link to the transition to compensated/decompaseted hf and death. the purpose of this work is to characterise myocardial fibrosis by any means to change the prognosis of patients with hf and preserved ejection fraction main purpose: assessment of cardiac fibrosis by echocardiography (speckle tracking), irm (late-enhancement imaging), biology (markers of collagen turn-over) and proteomics * patients selection 1. - inclusion criteria: male or female \> 18 and \ 50% with 72 hours after admission and bnp \> 100 ng/l or nt-probnp \> 300 ng/l), signed inform consent. 2. - exclusion criteria: hypertrophic cardiomyopathy, restrictive cardiomyopathy, constrictive pericarditis, significant respiratory disease, pulmonary hypertension, core pulmonale, end-stage kidney disease, high cardiac output hf, isolated right ventricular dysfunction, pregnancy or child-bearing, biventricular pacing, no health insurance. * control group 1. - inclusion criteria: male or female \> 18 and \< 85 years of age. signed inform consent. health insurance. 2. - exclusion criteria: significant ischemic heart disease, significant valvular heart disease, pericarditis, pulmonary hypertension, hypertrophic cardiomyopathy, restrictive cardiomyopathy, constrictive pericarditis, significant respiratory disease, pulmonary hypertension, core pulmonale, end-stage kidney disease, high cardiac output hf, isolated right ventricular dysfunction, pregnancy or child-bearing, biventricular pacing, no health insurance.

Eligibility criteria:
- inclusion signs of heart failure elevated bnp ef \> 50% within 72 hours after admission
reformative versus single step dilation percutaneous dilatational tracheostomy

Conditions: Respiratory Failure; Respiratory Depression

Summary: percutaneous dilatational tracheostomy (pdt), especially single-step dilatational tracheostomy (sd-pdt), is now frequently preferred to surgical tracheostomy. occasionally, it needs a second dilation maneuver .dissection of the deep cervical fascia during pdt, known as reformative pdt (re-pdt), may facilitate the procedure. this study was designed to compare re-pdt with sd-pdt in icu patients

percutaneous dilatational tracheostomy (pdt) is a popular airway management technique in the intensive care unit (icu).occasionally the first dilation may be challenging when using ciaglia and colleagues' method, and a second dilation may be needed to insert the tracheostomy tube. in these circumstances, potentially life-threatening complications, such as hemorrhage and hypoxia, may arise. the investigators found the reasons for difficulty in achieving smooth dilation of the stoma.the investigators compared the traditional method with the improved method.

Eligibility criteria:
inclusion criteria: * age ≥18 years; * requirement for long-term mechanical ventilation; * failure of weaning from mechanical ventilation. exclusion criteria: * age \<18 years; * pre-existing infection at the tracheostomy site; * pre-existing malignancy at the tracheostomy site; * difficulty in identifying the anatomic landmarks; * unstable cervical spine fracture; * international normalized ratio (inr) \>2; * platelet count \<50 000 mm3.

Keywords: tracheostomy，fascia，force gauge
acugraph and digestive symptoms

Conditions: Digestive Disorders; Irritable Bowel Syndrome; Constipation; Diarrhea

Summary: this research is designed to study the reliability of the results of an acugraph in college students and faculty members with reported digestive symptoms

the specific aim of the study is to test the reliability of the acugraph in subjects with irritable bowel syndrome (ibs). the hypothesis is that the acugraph will be a reliable method to identify disorders in subjects.

Eligibility criteria:
inclusion criteria: * subjects will be required to answer a questionnaire evaluating for a percentage of digestive disorders "disability" based on the subject's answers. if a participant's answers do not qualify as a disability, they will be assigned to the asymptomatic group and will still be examined with an acugraph to provide normative data. exclusion criteria: * heart condition * kidney disorder * thyroid disorders * diabetes * chronic disease or illness * neurological diseases * skin or bleeding disorders * pregnant * currently taking drugs or nutritional supplements * pacemaker and/or
autologous bone marrow mononuclear cell transplantation for stroke patients

Conditions: Cerebral Embolism; Stroke

Summary: the purpose of this study is to determine whether autologous bone marrow mononuclear cells transplantation after stroke is safe and/or effective to improve neurological outcome.


Eligibility criteria:
inclusion criteria: * patients with cerebral embolism. * nihss score is more than (or equal to) 10. * on day 7 after onset of stroke, the improvement of nihss is less than (or equal to) 5, compared with the level at administration. * bone marrow aspiration can be done in 10 days after onset of stroke exclusion criteria: * patient with cerebral hemorrhage or symptomatic hemorrhagic infarction. * patient who expects brain surgery. * patient with acute myocardial infarction. * patient with coagulation disorder. * number of platelet \< 100000/mm3 * serum creatinine level \>2.0mg/dl * patient with malignancy. * patient with uncontrolled proliferative diabetic retinopathy. * patient suspected infective endocarditis. * hbv, hcv, hiv or htlv positive

Keywords: stroke bone marrow mononuclear cell angiogenesis neurogenesis
the pathway pvd study for percutaneous peripheral vascular interventions

Conditions: Peripheral Artery Disease

Summary: the pathway pv atherectomy system is a rotating, aspirating, expandable catheter for active removal of atherosclerotic debris and thrombus in peripheral vasculature. this is a prospective, single arm, multi-center study to obtain safety and performance data for the pathway pv atherectomy system when used as a primary or adjunctive therapy for percutaneous intervention to remove atherosclerotic disease, debris, and thrombus from the lower limb peripheral vasculature.


Eligibility criteria:
inclusion criteria: * documented symptomatic atherosclerotic peripheral vascular disease * target lesion(s) is/are located in a superficial femoral, popliteal and/or infrapopliteal arteries * the patient has been informed of the nature of the study and has provided informed consent * the patient agrees and has capability to meet study requirements and be present at the follow-up clinic visits exclusion criteria: * target lesion is located in the iliac artery. * target lesion stenosis is \< 70%. * interventional treatment is intended for in-stent restenosis at the peripheral vascular site. * patient is unable to participate for the duration of the study. * patient is currently participating or has participated in a study with another investigational medical device or medication.
improving quality of life in heart failure

Conditions: Heart Failure; Quality of Life

Summary: this research study has been designed to test the efficacy of telephone-delivered problem-solving treatment (pst) for improving the quality of life (qol) in outpatients with stable heart failure (hf).

heart failure (hf) is the end stage of all cardiovascular diseases, and it imposes a huge burden in the united states in terms of morbidity, mortality, and economic cost. although disease management programs have been developed to curb these costs and address the complexities of hf management, evaluations of these programs have yielded equivocal results. with this study the investigators plan to: (1) to determine the feasibility of telephone delivered pst for outpatients with hf and reduced qol by obtaining estimates of yield, retention, patient acceptance, and patient satisfaction; (2) to determine whether telephone-delivered pst is associated with greater improvements in qol than telephone-delivered time management over 8 weeks; and (3) to determine whether telephone-delivered pst is associated with greater reductions in depressive symptoms and/or greater improvements in self-efficacy or objectively assessed daily physical activity than telephone-delivered time management over 8 weeks.

Eligibility criteria:
inclusion criteria: * outpatient * age \> 21 * exhibits symptoms of hear failure (nyha class ii or iii) * left ventricular ejection fraction (lvef) \>= 40% * kansas city cardiomyopathy questionnaire (kccq) summary score \< 60 exclusion criteria: * cannot speak english * lack telephone access * unwilling to be randomized, or * unavailable for the study period * awaiting a heart transplant (united network for organ sharing status 1a or 1b), or * planned (within 6 months) cardiac surgery * cognitive impairment indicative of dementia * recent (3 months) * acute myocardial infarction, * cardiac decompensation, or * hf-related hospitalization. * use intravenous inotropic medication * use an assistive circulatory device * significantly reduced life expectancy due to co-morbidity (e.g., malignancy) * currently receiving mental health counseling; * a history of: * bipolar disorder, * psychosis, or * substance abuse/dependency * severe depressive symptoms or suicidality
subcutaneous continuous versus interrupted sutures during cesarean section.

Conditions: Suture Line Infection

Summary: a comparison of the rate of surgical site infections after cesarean section depending on the type of suture used for subcutaneous closure-continuous versus interrupted.

patients at term that are candidates for elective cesarean section will receive an explanation regarding the study and sign informed consent. patients will then be divided randomly to one of 2 treatment groups based on the type of subcutaneous tissue closure: 1. interrupted sutures. 2. continuous sutures. information regarding medical and obstetric history will be collected for each patient.

Eligibility criteria:
inclusion criteria: * pregnant women undergoing elective cesarean section. * subcutaneous tissue layer\>2 centimeter according to ultrasound. exclusion criteria: * non-elective cs. * fever during the 48 hours prior to surgery. * antibiotic treatment during the 48 hours prior to surgery. * inability to give informed consent. * preterm delivery (\< 37 weeks' gestation). * fetal death. * known fetal anomalies or placental abnormalities. * immunosuppressive conditions.
evaluation of the gambling habits of adolescents and young adults post-covid-19 and implementation of a digital escape room intervention for preventing gambling in high school students

Conditions: Mental Health

Summary: gambling behaviors among adolescents and young adults have been experiencing an upward trend in the last years, possibly because of new habits developed during the covid-19 lockdown restrictions. different preventive strategies have been proposed: universal classroom-based interventions have shown promising evidence as preventive tools, but challenges exist in engaging the target audience effectively. serious games, i.e., those designed with the specific intent to educate, broaden knowledge, and change behaviors, have been tested with positive outcomes. digital escape rooms constitute a modality of serious game that has shown potential for a variety of educational purposes, but their efficacy for preventing addictive behaviors, as well as their long-term impact, has not been widely studied. the present project aims at assessing the gambling habits of a sample of 16-25-year-olds in the region of aragon, spain, that could be compared to the data gathered before the pandemic started, so not only the prevalence rates can be updated but also potential differences in habits (e.g., preferred gambling alternatives) can be detected. this will undoubtedly help the design of effective preventive measures, such as the gambl-out digital escape room, a serious game to be implemented in high schools with the aim of increasing knowledge, reducing intentions to gamble, and changing attitudes towards gambling.


Eligibility criteria:
inclusion criteria: * only high school students aged between 16 and 18 * being able to read and understand the spanish language * willingness to participate in the study and sign the written informed consent form exclusion criteria: * age: \ 18 years old