Kornimate/medical-research-clean huggingface dataset:
vitamin c depigmenattion versus conventional technique

Conditions: Melanin Hyperpigmentation

Summary: although physiologic gingival hyperpigmentation is not a pathologic condition, it is considered one of the main esthetic problems in dentistry. it was found that the attached gingiva is the most frequently pigmented intraoral tissues followed by the papillary gingiva and the alveolar mucosa

in addition to all of the previously mentioned actions of vitamin c, it was found to be involved in depigmentation due to several factors that not only depend on its direct effect on melanin and melanocytes but also due to the overall effect on the applied tissues. melanin is one of the main reservoir for ros, copper and calcium in the tissue cells . once vitamin c is introduced to the target tissue, it binds efficiently to melanin due to the ros, calcium and copper content which causes intracellular deficiency of these items and the inability of the cells to produce melanin. calcium deficiency causes failure of melanocytes to perform cellular adhesion to keratinocytes as calcium is essential to form cadherins . adhesion to keratinocytes is important stimulator to melanocytes in order to produce melanin, format dendrites and transfer the produced melanin to neighboring cells . shortage of the intercellular copper limits the formation of tyrosin, tyrosinase enzyme and peroxidase enzyme which in turn stops the melanin production . therefore, the aim of the present study is to compare the clinical efficiency of the non-surgical intraepidermal injection of vitamin c in comparison to the gold standard surgical technique (scalpel technique) for gingival depigmentation.

Eligibility criteria:
inclusion criteria: * aged 18-50 y * medically free; * physiologic gingival hyperpigmentation related to esthetic region were selected. exclusion criteria: all the reasons that could provoke an inflammatory reaction were excluded such as: * systemic diseases (especially auto-immune diseases and chemotherapy uptake); * pregnant and lactating mothers; * usage of chlorhexidine or povidone iodine; * local causes (smoking and periodontitis).
vitamin d and type 2 diabetes - a cross sectional study

Conditions: Hypovitaminosis D; Type 2 Diabetes Mellitus

Summary: the purpose of the study is to describe vitamin d status among patients with type 2 diabetes and to determine the association between serum 25-hydroxyvitamin d and glycemic control, markers of inflammation and blood pressure

it has been estimated that 1 billion people worldwide have vitamin d deficiency or insufficiency. it is well known that vitamin d deficiency causes osteoporosis, increases the risk of fracture and causes muscle weakness. but there is now evidence that calcium malnutrition and hypovitaminosis d are predisposing conditions for various common chronic diseases such as malignancies (particularly colon, breast and prostate) chronic inflammatory and autoimmune disease (inflammatory bowel disease, multiple sclerosis) as well as metabolic disorders (metabolic syndrome, hypertension). it has also been reported that vitamin d deficiency may predispose to glucose intolerance, altered insulin secretion and type 2 diabetes mellitus. the purpose of this study is to determine vitamin d status among type 2 diabetics in our outpatient clinic and examine the relationship between vitamin d status , calcium and phosphorous metabolism, inflammatory markers, glycemic control, blood pressure and lipid profile. moreover the patients are asked to answer a questionnaire regarding lifestyle, exercise, sun exposure and food intake.

Eligibility criteria:
inclusion criteria: * type 2 diabetes mellitus * patients of danish extraction * written consent exclusion criteria: * renal failure (urea \> 12 mmol/l) * age \< 18 years * malabsorption

Keywords: hypovitaminosis d type 2 diabetes glycemic control inflammation blood pressure
cross-cultural validity of edi-1 among clinical and non-clinical taiwanese population

Conditions: Eating Disorders

Summary: the aim of the study is to understand the clinical characteristics of taiwanese eating disorders as well as establishment of the psychometric properties of eating disorder-related questionnaires (edi and bite).

the study subjects include three group of population: 1st group is non-clinical nursing college students (n=800); 2nd group is clinical eating disorder patients (n=600) and 3rd group is age-, sex-matched clinical non-eating disorder patients (n=600). clinical patients are screened by eating disorder module of the scid and are grouped into eating disorder or non-eating disorder group. after written informed consent, eating disorder patients will receive clinical assessments which included important clinical characteristics and psychopathology of eating disorders by experienced senior psychiatrists. all clinical patients are asked to complete the self-rating scales which included eating and general psychological functioning questionnaires.

Eligibility criteria:
inclusion criteria: * patients with eating disorders, * patients with non-eating disorders, * nursing school students exclusion criteria: * none

Keywords: cross-cultural, eating disorders, edi, psychometrics
study examining the effect of a novel cannulation knife on user satisfaction and common central venous catheter insertion complications

Conditions: Central Venous Catheter Exit Site Infection

Summary: the purpose of this study is to assess user satisfaction and the frequency of common central venous catheter insertion complications when using a novel cannulation knife.

the primary objective is to assess user satisfaction with a new cannulation knife for central venous catheter (cvc) insertion. secondary objectives include assessing the frequency of skin incision revisions, frequency of procedures being aborted and restarted, frequency of reverting to the use of the scalpel customarily used to make the incision, frequency of bleeding around the catheter after completion of the procedure, assessment of time to final catheter placement, and the frequency of central line-associated bloodstream infections (clabsi). the cannulation knife will be studied in three clinical areas: * cardiovascular operating room * cardiovascular surgical intensive care unit * interventional cardiology a prospective cohort of 24 clinicians will be enrolled. each clinician will be asked to perform a total of five observed cannulations, resulting in a combined 120 observed procedures. in cases where both the clinician and patient are amenable, a video recording will be taken of the procedure to document the study variables of interest (duration of the procedure, need for revisions, the incidence of bleeding, size of the final incision, etc.) and allow for later review. all clinicians will be given a survey. this survey is designed to assess the clinicians impression of the device's benefit and the need for 1) revisions of the incision or, 2) aborting the initial attempt. clinicians will also be timed from procedure start to final catheter placement and will be monitored for incidence of common complications (back bleeding around the catheter, need to revise incision, need to abort/restart procedure) and need to revert to use of a standard scalpel. although clinicians are the primary focus of this investigation, patients will also be consented to the study and will be monitored for the development of clabsi post-procedure.

Eligibility criteria:
inclusion criteria: * patient requires a 5 french, 7 french, or 12-14 french central venous catheter. * operator responsible for insertion of central venous catheter. exclusion criteria: * patient unwilling to consent. * operator unwilling to complete the survey.
a study of an acetaminophen/naproxen sodium fixed combination, acetaminophen and naproxen sodium in postoperative dental pain

Conditions: Pain

Summary: the purpose of this study is to evaluate how well a fixed combination of acetaminophen/naproxen sodium relieves postoperative dental pain compared with acetaminophen, naproxen sodium and placebo.

this is a randomized, double-blind, placebo-controlled, single-dose full-factorial study to evaluate the analgesic efficacy and safety of a fixed combination of acetaminophen and naproxen sodium, compared with acetaminophen or naproxen sodium alone, and placebo following surgical extraction of three or four third molars.

Eligibility criteria:
inclusion criteria: * weigh 100 pounds or greater and have a body mass index (bmi) of 17.5 to 30.4 (inclusive) at screening * surgical removal of three or four third molars, of which, two must be mandibular impactions * meets requirements for post-surgical pain level * females of childbearing potential and males agree to contraceptive requirements of study * have a negative urine drug screen at screening, and on day of surgical procedure exclusion criteria: * pregnant female, breastfeeding, trying to become pregnant or male with pregnant partner or partner currently trying to become pregnant * have a known allergy or hypersensitivity to naproxen (or other nsaids including aspirin) or to acetaminophen, oxycodone or other opioids * not able to swallow whole large tablets or capsules * history of any condition(s) in investigator's opinion, may jeopardize subject safety, well-being and integrity of study * use analgesics 5 or more times per week * history of chronic tranquilizer use, heavy drinking, or substance abuse, as judged by the investigator site staff, in the last 5 years * use any immunosuppressive drugs within 2 weeks of surgical procedure * history of endoscopically documented peptic ulcer disease or bleeding disorder in the last 2 years

Keywords: analgesics dental pain acetaminophen naproxen sodium pain fixed-dose
use of injectable-platelet-rich-fibrin (i-prf) to thicken gingival phenotype

Conditions: Periodontoclasia; Gingiva; Injury; Condition; Blood Clot; Gingiva Disorder

Summary: the main objective of this study is to investigate whether the for individuals with thin gingival thickness who are susceptible to gingival recession, the investigators will use i-prf with microneedle to increase gingival thickness without the need for surgical procedures

due to the thin gingival phenotype, gingival recession is a problem. the investigators aimed to increase the gingival thickness using i-prf with microneedle without considering surgical procedures, considering the positive effects of platelet concentrations on revascularization and wound healing in individuals with bone defect, fenestration and gingival thickness which are prone to gingival recession .

Eligibility criteria:
inclusion criteria: * never smokers * had no history of systemic disease * aged ≥18 years old exclusion criteria: * patients with a history of diabetes mellitus or systemic disease * patients who were under any medication that was known to influence periodontal tissues * patients with hormonal changes such as pregnancy or lactation * toothless individuals * patients who were clotting disorders

Keywords: prf i-prf microneedle gingival thickness injectable-platelet-rich-fibrin platelet rich fibrin
in-hospital hyperglycemia: effects of treatment on glycemic control and clinical outcome

Conditions: Diabetes; Hyperglycemia

Summary: to improve glycemic control of inpatients admitted to the internal medicine wards, the researchers generated a protocol based on intensive insulin treatment for use in all inpatients with hyperglycemia. the researchers hypothesize that intensive insulin treatment will improve the glycemic control and the outcome of hospitalized patients. study information: * all patients with a history of diabetes admitted to the internal medicine ward were enrolled in the study. * at baseline, demographic and clinical information were obtained, including information necessary to determine the severity of the illness. venous capillary blood glucose levels were checked 4 times a day by glucometer. * during the pre-intervention period, patients were treated according to the common practice in the hospital without any intervention. the study team collected the baseline data on the glycemic control and treatment of patients admitted with hyperglycemia. * during the intervention period, the study team visited the ward daily and guided the medical staff as to the use of the treatment protocol. * during the post-intervention period, the study team collected the data without active intervention in the implementation of the protocol. * data was collected on the mode of treatment and glycemic control of all hyperglycemic patients throughout the study. the incidence of hypoglycemia, complications (myocardial infarction, stroke, infections), mortality, transfer to intensive care unit (icu), length of hospitalization, and disposition at discharge were noted.


Eligibility criteria:
inclusion criteria: * all patients admitted to the internal medicine ward with hyperglycemia exclusion criteria: * patients admitted due to hypoglycemia, hyperosmolar state, and ketoacidosis

Keywords: diabetes hyperglycemia hospital medicine ward
exosome as integrative tool for prognostic stratification of adverse cardiac remodeling in stemi patients: the miracle study

Conditions: STEMI

Summary: this is a multicenter observational prospective study aimed to assess whether plasma exosomes can help identify, at an early stage, patients at high risk of adverse remodeling after stemi (st-elevation myocardial infarction) , thus accelerating proper patient management in order to reduce the risk of future cardiovascular events. in order to study the correlation between exosome profile and severity of myocardial infarction, consecutive stemi patients will be enrolled 3 days after percutaneous coronary intervention (pci).

adverse cardiac remodeling is a process of structural and functional changes associated with worse clinical outcomes and increased mortality, which occurs in response to sustained pathophysiological stimuli, such as st-elevation myocardial infarction (stemi). despite the progresses achieved with reperfusion therapy in stemi, a significant portion of patients still develops adverse remodeling. cardiovascular magnetic resonance (cmr) is the gold standard for clinical diagnosis of adverse remodeling, as it provides reliable and reproducible information on ventricular size, function and tissue damage. however, cmr is not always applicable, due to resources and availability reasons and to patients' contraindications. therefore, additional markers for the early detection of patients at risk for adverse remodeling after stemi are needed. exosomes are small extracellular vesicles released by cells and detectable in all body fluids, including plasma. their release and cargo are influenced by cellular microenvironment, thus mirroring cell/organ status. previous study demonstrated that concentration and cargo of plasma exosomes released during stemi well reflect the pathophysiology of the disease, suggesting their potential as biomarkers. whether exosome profile analysis could predict adverse remodeling after stemi remains to be investigated. the relevant hypothesis to be tested is whether plasma exosomes may help to identify, in an early phase, patients at high risk of adverse remodeling after stemi, accelerating proper patient management in order to reduce risk of further cardiovascular events and improve outcomes. overall, this new knowledge will pave the way toward a new strategy to predict adverse remodeling in stemi patients and to develop patient-tailored therapy.

Eligibility criteria:
inclusion criteria: * chest pain suggestive of myocardial ischemia lasting \>30 min * electrocardiogram (ecg) showing st-segment elevation \>0.1 mv in more or equal to 2 limb leads or \>0.2 mv in more or equal to 2 contiguous precordial leads, or presumed new left bundle-branch block * successful treatment with ppci within 12 h from the onset of symptoms exclusion criteria: * previous myocardial infarction (mi) * time to ppci \>12 h * atrial fibrillation * renal failure with glomerular filtration \<30 ml/min * claustrophobia * other contraindications to cmr.

Keywords: cardiovascular magnetic resonance pci exosome
to investigate the pharmacological effects, drug blood levels and safety of an intrauterine system releasing the study drug bay1007626 in comparison to mirena and jaydess in healthy young women treated for 90 days to determine the drug dose for further development

Conditions: Contraception

Summary: investigation of pharmacological effects, drug blood levels and safety of an intrauterine system releasing the study drug bay1007626 in comparison to mirena and jaydess in healthy young women treated for 90 days to determine the drug dose for further development


Eligibility criteria:
inclusion criteria: * healthy female subject. * willingness to use non-hormonal methods of contraception during the study. * this applies during the cycle preceding the pre-treatment cycle until the end of follow-up. * age at screening: 18-40 years inclusive. * body mass index (bmi) at screening: ≥ 18 and ≤ 32 kg/m². * history of regular cyclic menstrual periods. * no clinically relevant abnormal findings in the pre-treatment endometrial biopsy. exclusion criteria: * incompletely cured pre-existing diseases for which it can be assumed that the absorption, distribution, metabolism, elimination and effects of the study drugs will not be normal. * any presence or history of known or suspected malignant tumors, especially any known or suspected breast cancer or other progestin-sensitive cancer. * any presence or history of known or suspected benign tumors of the liver or of the pituitary or adrenal gland. * amenorrhea (with unknown reason, not amenorrhea due to hormonal treatment) for more than 3 months within the 6 months before the first screening examination. * use of short-acting preparations containing sex hormones during the cycle preceding the pre-treatment cycle (oral, transdermal, intravaginal, ius). * use of long-acting preparations containing sex hormones within the 40 weeks before the first screening examination (any long-acting injectable or implant). clinically relevant findings in the physical examination (e.g. pronounced varicosis, thrombophlebitis, and evidence of peripheral circulatory disturbances). menstrual disorders with suspicion of ovarian failure (e.g., oligomenorrhea, amenorrhea, hypomenorrhea). * known bleeding irregularities * current or recurrent pelvic inflammatory disease, including pelvic inflammatory disease within 6 month prior to the insertion of the ius and any active sexually transmitted disease. * anovulatory pre-treatment cycle (ovulation has to be observed by day 27 at the latest). * positive result of urine pregnancy test.
a prescription support tool for oral antithrombotic combinations

Conditions: Antithrombotics Prescriptions

Summary: from a systematic review of international guidelines (2012-2018), a prescription support-tool synthesizing national and international guidelines on chronic management (≥ 1 month) of oral at agents without considering in-hospital management and bridging therapy will be developed. guidelines dealing with the use of oral ats for non-valvular atrial fibrillation, coronary artery disease, ischemic stroke, valvular heart disease, peripheral artery disease and venous thromboembolism in adults will be included. these pathologies were selected because most prescriptions of ats are related to neuro-cardiovascular diseases and because this study would provide a synthesis relevant for clinicians in charge of the follow-up of patients with oral at combinations. studies are needed to assess the impact of this tool on appropriate prescribing.

oral antithrombotic (at) drugs are widely implicated in serious and preventable bleeding events, which justifies the implementation of risk minimization actions. avoiding inappropriate oral at combinations is a major concern, particularly for patients with multiple chronic conditions. the first step is to provide fast and easy access to the latest recommendations. from a systematic review of international guidelines (2012-2018), a prescription support-tool synthesizing national and international guidelines on chronic management (≥ 1 month) of oral at agents without considering in-hospital management and bridging therapy will be developed. our main objective in this study is to evaluate the accuracy of this tool by measuring the appropriateness of oral at prescriptions according to the most recent guidelines. methods and analysis: in this web-based randomized controlled trial, participating french general practitioners and cardiologists in the outpatient setting will be randomized by use or not of the prescription support-tool. they will be asked to provide the number of drugs, drug class, duration and dosage of ats, within a time window of 10 minutes, for 3 different clinical situations presented as clinical vignettes (multiple-choice questions). the scientific committee has created and validated 30 clinical vignettes illustrating outpatient clinical situations for which the use of oral ats (single, dual or triple therapy) is recommended or not according to the guidelines. all data will be treated anonymously. ethics and dissemination: if the prescription support-tool is associated with more appropriate prescription of at combinations, its dissemination to further evaluate outcome data including haemorrhage, ischemic events, and death will be considered.

Eligibility criteria:
inclusion criteria: * french practicing physicians who are involved in outpatient settings, including general practitioners and cardiologists. exclusion criteria: * physicians with an exclusive hospital practice.
is acne a skin disease affecting the brain functions? neurocognition in patients with acne vulgaris

Conditions: Acne Vulgaris

Summary: acne vulgaris usually causes psychological distress, depression, and anxiety disorders that may impair neurocognitive functions such as memory, attention, psychomotor speed, and executive functions, which are also common psychiatric disorders in patients with acne. the purpose of this study is to determine cognitive functioning in treatment naive acne patients, without a history of any psychiatric disorder.


Eligibility criteria:
inclusion criteria: - exclusion criteria: the participants that had a symptom or a history of mental retardation (iq \< 70), serious head trauma, seizures or any other mental disorder, and participants on any medical treatment will be excluded. participants with a family history (first degree relatives) of schizophrenia, bipolar disorder or schizoaffective disorder will also be excluded to avoid the negative effect of these disorders on cognitive functions. the same exclusion criteria will also be applied to the control group.

Keywords: acne vulgaris cognitive functions
hormonal and lipid levels in male subjects after a switch from carbamazepine to lacosamide

Conditions: Epilepsy, Partial

Summary: the purpose of the trial is to investigate whether changes in lipids and hormonal parameters can be observed in blood when carbamazepine treatment is replaced with lacosamide treatment, while levetiracetam treatment remains unchanged.


Eligibility criteria:
inclusion criteria: * male subject with diagnosis of epilepsy with partial-onset seizures * subject only taking levetiracetam in combination with carbamazepine as adjunctive treatment for epilepsy exclusion criteria: * subject is taking another anti-epileptic drug (aed) than carbamazepine (cbz) and levetiracetam (lev) * subject is taking lipid lowering agents * subject is taking enzyme inducers

Keywords: vimpat partial seizures carbamazepine hormone levels lipid levels lacosamide