Kornimate/medical-research-clean huggingface dataset:
dry needling for cervicogenic headache

Conditions: Headache

Summary: currently, it is unknown if dry needling when performed to the trigeminal innervation field improves neck pain and or headache for patients with cervicogenic headaches. the aim of this study is to determine if dry needling of the trigeminal innervation field improves pain, pain-pressure thresholds, and neck mobility in patients with cervicogenic headaches, with or without migraine.

dry needling is a widely used intervention performed by physical therapists for a wide range of musculoskeletal and neurological conditions. dry needling has been shown to be beneficial for cervicogenic headaches but treatment is typically applied to the neck. it is well-established that cervical pain can upregulate the trigeminal nerve and vice versa in various forms of headaches. thus, it is plausable that reducing inflammation and irritation of the trigeminal nerve may in fact reduce neck pain and impairments. this study aims to look investigate whether dry needling the trigeminal innervation field will reduce pain and impairments known to exist in patients with cervicogenic headaches compared to a sham comparator. the study is a pilot trial for a larger rct and will look at immediate effects only.

Eligibility criteria:
inclusion criteria: * aged 18 or older * symptoms: (1)unilateral pain starting in the neck and radiating to the frontotemporal region or posterior fossa, (2) pain aggravated by neck movement, (3) restricted cervical range of motion, (4) non-throbbing and non-lancinatingnpain, 5) dysfunction/headache pain in at least one of the joints of the upper cervical spine(c0-c4), and (6) headache frequency of at least 1 per week over a period greater than 3 months. exclusion criteria * pain \<2/10 * contraindications to the interventions * whiplash associated disorder within 6 weeks * pending litigation for neck pain and/or headache.
evaluating the anticancer learning circle lifestyle program in endometrial cancer survivors

Conditions: Neoplasm, Uterine

Summary: the purpose of this study is to promote positive lifestyle change among endometrial cancer survivors by using a group-based intervention. endometrial cancer survivors are at an increased risk of other health conditions like heart disease, diabetes, and other cancers. the study team at the university of virginia wants to explore new ways to lower these risks. this study will be evaluating the anticancer lifestyle program, which takes a more holistic approach and uses web-based learning modules along with weekly group sessions to discuss each topic of the web-based learning modules.


Eligibility criteria:
inclusion criteria: * history of stage i-iv endometrial cancer, any histologic subtype * completed cancer treatment, and in surveillance * have no evidence of endometrial cancer as determined by primary oncologist * be at least 18 years of age * be able to read and communicate in english * have a smartphone with access to cellular service or computer access with internet service * must have technological competency/proficiency to use their smartphone and/or computer, as self-reported by potential subject * stated willingness to comply with all study procedures and availability for the duration of the study. exclusion criteria: * pregnant women * prisoners * subject is blind

Keywords: endometrial cancer holistic cancer treatment lifestyle change
stress free now in a corporate call center

Conditions: Stress, Psychological

Summary: psychosocial stress increases the risk for a multitude of diseases, including obesity, hypertension, and cardiovascular disease. stress may also result in increased utilization of health care services. in the workplace, stress leads to emotional exhaustion, job dissatisfaction, lower productivity and impaired performance. stress management programs and those based on mindfulness meditation have gained popularity in recent years. the purpose of this study is to evaluate the feasibility of an 8-week web-based mindfulness stress reduction program and its effectiveness in reducing work related stress and improving well-being in a large corporate call center.


Eligibility criteria:
inclusion criteria: * frontline employee of large corporate call center * internet access exclusion criteria: * manager or supervisor of large corporate call center
the bialystok bariatric surgery study

Conditions: Obesity; Diabetes Mellitus; Metabolic Syndrome; Dyslipidemias; PreDiabetes

Summary: the bialystok bariatric surgery study (bbss) is a prospective observational cohort study of patients undergoing bariatric surgery at the first clinical department of general and endocrine surgery at the medical university of bialystok. the bbss consists of a battery of baseline tests established one month prior to the surgery and repeated at one, three, six, twelve and twenty four-month follow-up clinical visits.


Eligibility criteria:
inclusion criteria: * bmi ≥ 40 kg/m2, or bmi ≥ 35 and at least one or more obesity-related co-morbidities such as type 2 diabetes (t2d), hypertension, sleep apnea and other respiratory disorders, non-alcoholic fatty liver disease, osteoarthritis, lipid abnormalities, gastrointestinal disorders, or heart disease. * inability to achieve a healthy weight loss sustained for a period of time with prior weight loss efforts * patient consent for participation in research project * willingness in participation in follow-up visits exclusion criteria: * substance abuse, * uncontrolled psychiatric illness * expected lack of compliance * advanced-stage cancer non-obese control group: * bmi \<30

Keywords: bariatric surgery diabetes treatment prediabetes treatment metabolic surgery
effect of a collagen hydrolysate on postprandial blood glucose profile in prediabetic and healthy subjects

Conditions: Healthy; Prediabetic State

Summary: to investigate the effect of two different dosages collagen hydrolysate (ch) on postprandial blood glucose and insulin profile in prediabetic and normo-glycaemic subjects.this will be investigated in a cross-over randomized double-blind placebo controlled study design.


Eligibility criteria:
main inclusion criteria: * prediabetic subjects: male and female subjects with prediabetic hba1c values between 5.7% and 6.4% and/or fasting glucose ≥ 100 mg/dl and ≤ 125 mg/dl (in venous plasma) (twice confirmed at two independent days if hba1c is \< 5.7%) or healthy normo-glycaemic subjects: fasting glucose \<100 mg/dl and hba1c is \< 5.7% * age: 18-70 years * body mass index 19-35 kg/m2 * current non-smoker * signed informed consent form * no changes in food habits or physical activity 3 months prior to screening and during the study * if applicable, stable intake of chronic medication of at least 4 weeks main exclusion criteria: * subjects with diagnosed type 2 diabetes mellitus with medical treatment * presence of disease or drug(s) influencing digestion (incl. recent intake of antibiotics) and absorption of nutrients * intake of medications known to affect glucose tolerance, e.g., diabetic medication, sglt-2 inhibitors, glp-1 receptor agonists, steroids, protease inhibitors or antipsychotics * chronic intake of substances affecting blood coagulation (e.g. acetylic acid (100 mg as standard prophylactic treatment allowed when dose is stable 1 month prior to screening), anticoagulants, diuretics, thiazides (diuretics and thiazides allowed e.g. for hypertension treatment when dose is stable 1 month prior to screening)), which in the investigator's opinion would impact patient safety * severe liver or renal disease or laboratory evidence of hepatic dysfunction (i.e. alkaline phosphatase, alt, ast \>3 x uln) * known inflammatory or malignant gastrointestinal diseases (i.e. colitis ulcerosa, morbus crohn, celiac disease, malignant diseases e.g. colon-cancer, rectum cancer, pancreatitis) * clinically relevant findings as established by medical history, physical examination, clinical laboratory and/or vital signs * intake of food supplements known to affect glucose tolerance, e.g., cinnamon capsules, conjugated linoleic acids * drug-, alcohol- and medication abuses * pregnant or breast-feeding women

Keywords: collagen peptides blood sugar modifying
prenatal administration of spermine promotes maturation of premature fetal gut epithelial tight junction: experimental study on fetal rabbit

Conditions: Premature Birth; NEC

Summary: infections, particularly on the gastrointestinal tract, has been known to be one of the leading causes of death in preterm infants. this is due to the immaturity of the intestinal epithelial cells. recent studies have shown that polyamines have a role on the development of cells during embryonal phase. by this experimental study, the investigators would like to evaluate the administration of spermine on the maturation of premature fetal gut epithelial tight junction.

this experimental study is conducted with minimum 24 subjects which divided into 6 groups; 1) 24-days pregnant and is given prenatal spermine, 2) 26-days pregnant and is given prenatal spermine, 3) 28-days pregnant and is given prenatal spermine, 4) 24-days pregnant and is not given prenatal spermine, 5) 26-days pregnant and is not given prenatal spermine, and 6) 28-days pregnant and is not given prenatal spermine. at the end of desired pregnancy period, hysterectomy is done and fetus are born. from each parent subject, three fetal samples are chosen using a random sampling. intestinal tissues are taken from each fetal sample to be examined. several data will be collected i.e. occludin, β-catenin, and β-actin, as well as histological morphologies.

Eligibility criteria:
inclusion criteria: * intestinal tissue of fetal rabbit that is prematurely alive exclusion criteria: * intestinal tissue of fetal rabbit that is dead before termination * intestinal tissue of fetal rabbit, in which the parent died before termination

Keywords: premature birth spermine necrotizing enterocolitis tight junction
prospective open clinical and genetic study of patients with retinitis pigmentosa

Conditions: Retinitis Pigmentosa; Usher Syndromes

Summary: this study is aimed to characterize russian population of retinitis pigmentosa

this study is aimed to characterize russian population of retinitis pigmentosa. tasks: stage 1. formation of the primary cohort of patients. patients pre-recruiting will be performed based on deaf-blind support foundation "con-nection" patient database analysis and from references. patients with clinically confirmed retinitis pigmentosa will be evaluated according to available data of the clinical examination. stage 2. genetic study of patients. all enrolled patients will undergo single 4 ml peripheral venous blood sampling. dna will be extracted from leucocytes. dna samples will be analyzed and placed for long-term storage in liquid nitrogen. stage 3. clinical examination of patients. each patient will undergo the following diagnostic procedures according to the unified protocol: * visometry (with correction and without correction) * ophthalmoscopy * perimetry * optical coherence tomography * electroretinography * visually evoked potentials * refractometry * pneumotonometry * biomicroscopy * any additional examinations and consultations if necessary medical record will be developed and maintained for each patient consisting results of extended clinical examination. statistical and bioinformatic analysis of detected genetic mutations in the study cohort will be performed.

Eligibility criteria:
inclusion criteria: * patient fulfill the clinical characteristics for retinitis pigmentosa (ad, ar, x-linked, sporadic) as defined by the retinitis pigmentosa consortium * results of perimetry for each eye show narrowing for 15 degrees or more. * patient is familiar with participant information sheet * patient signed informed consent form non-inclusion criteria: * participation in other clinical trials (or administration of investigational drugs) during 3 months prior inclusion * any conditions limiting compliance (dementia, neuropsychiatric disease, drug and alcohol abuse etc.) * medical history of traumatic injury of eyes, barotrauma, concussion, craniocerebral trauma, cerebrovascular accident * congenital multiple development orbit and eye malformations exclusion criteria: * patient's refusal from the further participation in the trial * decompensated diabetes mellitus * severe coronary artery disease * chronic infectious disease * patients with malignant tumors including postoperative period, patients receiving chemotherapy and/or radiotherapy
comparing two methods of subacromial space injection

Conditions: Subacromial Impingement Syndrome

Summary: subacromial shoulder injections can be approached from the front or side of the shoulder. the investigators are comparing both methods, to find which one has better spread in the subacromial space.

both lateral and posterio-lateral methods of subacromial injections are widely used for diagnostic and therapeutic purposes. it is not known which method allows the most accurate access into the subacromial space and is more effective. the investigators have been using a novel approach from the anterior aspect of the shoulder for years with good clinical effect and propose comparing this approach to the described approach. this study will indicate which method is best and will be of practical clinical importance. the investigators feel the technique is easier to perform than other described methods and could be taught to clinicians throughout the country and adopted as the standard approach.

Eligibility criteria:
inclusion criteria: * shoulder pain for at least 6 weeks duration along the lateral aspect of the shoulder. * positive impingement signs. exclusion criteria: * history of compensation claim due to shoulder problems. * allergy to radiographic dye. * recent shoulder fracture. * bleeding disorder. * previous shoulder surgery.
clinical study to evaluate the safety and tolerability of macitentan in subjects with combined pre- and post-capillary pulmonary hypertension (cpcph) due to left ventricular dysfunction

Conditions: Pulmonary Hypertension

Summary: study to evaluate if macitentan is safe and tolerable enough to be used for treatment of subjects with combined pre- and post-capillary pulmonary hypertension (cpcph) due to left ventricular dysfunction.


Eligibility criteria:
inclusion criteria: 1. males and females \>=18 years of age 2. subjects with combined pre-and post-capillary pulmonary hypertension (cpcph) due to left ventricular dysfunction (subset of who groups 2.1 and 2.2) 3. optimized diuretic therapy exclusion criteria: 1. types of pulmonary hypertension other than who groups 2.1 and 2.2 (nice classification) 2. administration of pah-specific therapy (i.e., endothelin receptor antagonists (eras), prostanoids, phosphodiesterase 5 (pde-5) inhibitors, guanylate cyclase stimulators)

Keywords: pre- and post-capillary pulmonary hypertension cpcph
helping children's centres to enhance home safety

Conditions: Burns; Smoke Inhalation Injury

Summary: many children have accidents, some are very serious and they are a major cause of death in children aged 1-4 years. many accidents are preventable this study aims to find out the best way to help children's centres to provide home safety information about preventing fires to parents and carers of young children. 36 children's centres in four study centres, nottingham, bristol, norwich and newcastle will be recruited to the study. 30 families will be recruited from each children's centre. children's centres serving the most deprived populations will be eligible to take part. families will be eligible to take part if they have attended a participating children's centre in the previous three months, have parents who are 16 years or older, have a child under three years old and live within the catchment area of that children's centre. when 30 families have been recruited that centre will be allocated, at random, to one of three groups. children's centres in group one will be provided with guidance about preventing fire-related injuries (an injury prevention briefing (ipb))and help and support to implement the ipb, the second group will be sent the ipb and the third group will not be provided with the ipb ('usual care'). children's centres will devise their own programmes of safety advice for parents based on the ipb. at recruitment and 12 months later, families and children's centres will complete questionnaires about fire safety practices. children's centres will also complete a paper-based tool about the implementation process at 12 months. information about barriers and facilitators to implementing the ipb will be collected through interviews with children's centre staff. the study will run from may 2011 to march 2014.


Eligibility criteria:
inclusion criteria: there are two levels of participation, children's centres as participants, who will be delivering the intervention, and families as participants, who will be receiving the intervention. children's centres: phase 1 children's centres in the four study areas (nottingham, newcastle, bristol and norwich) phase 2 children's centres in more disadvantaged areas (defined as those who have more than 50% of under 5 year-old children in their centre catchment area who live in one of the 30% most disadvantaged super output areas). families any family who has attended the participating children's centre in the previous three months, who have a child under three years old, and lives within the catchment area of that children's centres. exclusion criteria: children's centres: phase 2 children's centres that are not in more disadvantaged areas as defined above and phase 3 or subsequent wave children's centres. families families who attend a participating children's centre who do not have any children under the age of 3 years any parent who is under-16 years of age.

Keywords: cluster randomised controlled trial community health services prevention & control accidents, home child health services
variants of sars-cov-2 causing covid-19 in africa

Conditions: COVID-19

Summary: the main objective of this research is to identify and characterize the different molecular variants of sars-cov-2, emerging and / or circulating in several countries of sub-saharan africa (burkina faso, côte d'ivoire, gabon, mali, chad and republic of congo) and determine their role in the evolution of the pandemic.

the main objective of this research is to identify and characterize the different molecular variants of sars-cov-2, emerging and / or circulating in several countries of sub-saharan africa (burkina faso, côte d'ivoire, gabon, mali, chad and republic of congo) and determine their role in the evolution of the pandemic. the research will combine retrospective and prospective approaches to determine the evolutionary dynamics of the virus since the start of the pandemic. it is planned to sequence the entire spike protein gene for 1550 viruses and make 300 entire genomes. this work will be supplemented by antibody seroneutralization and respiratory transcriptomics tests, in order to estimate the immuno-virological response of the covid-19 disease associated with the identified sars-cov-2 variants.

Eligibility criteria:
inclusion criteria: * major subject (cf. country) * presenting for a sars-cov-2 diagnosis, whether symptomatic or not * not objecting to participating in the research exclusion criteria: * na
vitamin d in pregnancy and lactation

Conditions: Vitamin D Deficiency

Summary: background: vitamin d is vital throughout pregnancy and lactation for both maternal and infant health. health canada recommends women take the ai of 5ug/day of vitamin d during pregnancy, however, it is unknown how much vitamin d is necessary to ensure both mother and baby reach a vitamin d serum concentration of 25ohd\>75nmol/l.

purpose \& hypothesis: this project aims to determine maternal and infant responses vitamin d supplementation in pregnancy and lactation. it is hypothesized that the current ai of 5 μg of vitamin d will be inadequate for women and their infants in canada to achieve optimal 25ohd concentrations (\> 75nmol/l). methods: healthy pregnant women between 18-42 years of age without history of pregnancy complications will be recruited for a double-blind, randomized, controlled trial where they will receive one of three different dosages of vitamin d (10, 25 and 50ug/day) as part of a standard prenatal vitamin. the study at 18 plus/minus 3 weeks gestation and will carry on throughout pregnancy and lactation. mother and infant vitamin d levels in breast milk and blood will be measured at regular intervals. skin colour will be measured via light reflectometry. bone biomarkers such as plasma osteocalcin and urinary n-telopeptide will be assessed. dietary vitamin d intake and sun exposure will be estimated using a food frequency and lifestyle questionnaire. data will be analyzed using multiple regression analysis controlling for baseline values. expected results \& conclusions: it is expected that greater vitamin d intakes (25, 50ug/day) will be necessary to raise maternal and infant serum concentrations to 25ohd\>75nmol/l to avoid infant supplementation. this data will aid policy makers, mothers and healthcare workers in recommended and appropriate vitamin d dosage throughout pregnancy and lactation.

Eligibility criteria:
inclusion criteria: * women between 18-42 years of age * within 18 plus/minus 3 weeks gestation * planning to breastfeed their infant * a singleton pregnancy exclusion criteria: * any co-morbid condition such pre-gestational diabetes, tb, cardiac or renal disease, hiv/aids, chronic hypertension, inflammatory bowel disease, autoimmune disease, liver disease, or epilepsy; conditions associated with vitamin d malabsorption: celiac disease, gastric bypass; * history of previous adverse pregnancy outcome \[preterm delivery \<37; weeks ga, stillbirth, severe pre-eclampsia, eclampsia, hellp syndrome (hemolytic anemia, elevated liver enzymes, and low platelet count)\]; * women will also be ineligible if they are taking more than 10 µg day supplemental vitamin d or drugs known to interfere with vitamin d metabolism (i.e corticosteroids).

Keywords: vitamin d infant lactation dose-response
bioengineered collagen implant for urethral stricture repair

Conditions: Urethral Stricture

Summary: the field of research for this study is tissue engineering and the utilization of a bioengineered collagen implant as a substitute biomaterial for conventional buccal mucosa in substitution urethroplasty of distal urethral strictures.

urethral stricture is defined as the abnormal narrowing of the urethral lumen in the area of the corpus spongiosum. a stricture is the result of ischemic spongiofibrosis manifesting as scar tissue in the corpus spongiosum. long-term consequences are chronic fistulation through the skin, recurrent sepsis, bladder stones, obstructive uropathy, obstructive nephropathy, and finally renal failure. current available surgical techniques for urethral stricture repair require harvesting of grafts from autologous sites resulting in additional risks of complications at the tissue harvest site and additional pain to the patient. the hypothesis of this study is that the developed bioengineered collagen implant can be used as an alternative biomaterial to buccal mucosa for substitution urethroplasty in urethral stricture patients.

Eligibility criteria:
inclusion criteria: adult males with urethral stricture less than 3 cm (anywhere from penile to bulbar urethra not including the membranous urethra) with existing lumen of at least 6 fr suitable for augmentation urethroplasty. the stricture may be due to trauma or infection. exclusion criteria: * known bovine collagen allergy * current urinary tract infection * chronic renal failure * diabeted * neurological diseases * chronic obstructive pulmonary diseases * sleep disturbances * depression * former cancer treatment * smokers * recurrent stricture