Kornimate/medical-research-clean huggingface dataset:
impact of stimulants and in-scanner motion on attentive task performance in adhd (adhd_nfb)

Conditions: ADHD

Summary: the goal of this interventional study is to learn the effects that stimulant medication prescribed to adhd individuals has in their performance of attentive tasks, as measured by images and data collected through neuroimaging (fmri) while also implementing new motion-correcting software. the main questions it aims to answer are: 1. how do the use of stimulants affect brain activity and motion in fmri research in adhd studies? 2. can neurofeedback, an attentive task using real-time brain activity, engage the same brain circuits as seen with stimulant medication in individuals with adhd? researchers will compare participant's brain activity from the completion of attentive tasks performed in the scanner while following their regular medication regimen and while abstaining to take medication. researchers will also compare how the data collected using a more precise motion correction software differs to other previously reported data from adhd studies who possibly employed more lenient measures of motion correction. participants will: 1. be asked to complete at least 4 fmri sessions, two of which will include neurofeedback 2. be asked to abstain from taking stimulant medication on the day of two of these fmri visits 3. complete attentive tasks while in the scanner that will activate target brain regions of interest


Eligibility criteria:
inclusion criteria: * age 12 or older * able to follow verbal and written instructions in native language * pre-existing clinical adhd diagnosis (with or without comorbid anxiety diagnoses) * pre-existing medication regimen of methylphenidate or amphetamine salt derivatives with no changes in the last month exclusion criteria: * known visual impairment preventing test administration * contraindication of inability to participate in fmri scanning (per mri screening form) * known, self-reported non-incidental structural brain abnormality * autism spectrum disorder or obsessive-compulsive disorder * non-verbal

Keywords: adhd neurofeedback fmri attention tasks motion
randomized controlled trial of subcuticular skin closure versus steri-strip s closure

Conditions: Breast Hypertrophy; Abdominal Elastosis; Breast Reconstruction

Summary: purpose: the aims of this randomized clinical trial are: 1. to assess scar quality from the patient and surgeon perspectives 2. to assess patient comfort in the days immediately following surgery 3. to assess the time taken to complete closure in the operating room. 4. the financial benefit or cost for the institution of using steri strip s will also be estimated. two closure methods will be compared, a new coaptive film device (steri strip s) versus standard subcuticular sutures. the linear incisions will include the standard incision segments utilized for an inverted-t closure for bilateral breast reduction and the transabdominal incision segments utilized for abdominoplasty or tram flap harvest. our hypothesis is that incisions segments closed with steri strip s compared to standard subcuticular closure, will yield scars of better cosmetic quality, in shorter time to closure, with novice and expert surgeons, for both bilateral breast reduction and abdominoplasty surgical procedures.


Eligibility criteria:
inclusion criteria: * patients are eligible for enrollment if they agree to provide informed consent, are at least 18 years of age, in generally good health, and available for follow-up in the 5-7 month time frame. exclusion criteria: * women known to be pregnant, minors, patients potentially incompetent to provide informed consent or complete the surveys described in our protocol will be excluded from this trial.

Keywords: skin closure devices linear scars
depressive state after sleeve gastrectomy

Conditions: Obesity, Morbid; Depression

Summary: obesity is an epidemic disease that continues to increase causing morbidity and mortality to those who suffer. obese patients suffer, frequently, from a depressive state, anger, and emotional disturbances. it cannot be recognized and depression causes obesity affecting eating habits or obesity causes depression based on physical, social and occupational limitations. many times we see that obese patients are discriminated in every sense of daily life increasing their depressive state. the best treatment for obesity is bariatric surgery that causes a sufficient weight loss to correct sleep apnea, diabetes, hypertension, and many other co-morbidity. the study is based on elucidating the effect of sleeve gastrectomy in obese patients suffering from depression

the patients were classified as suffering from a depressive state before the bariatric surgery and followed until 3 years after surgery, the data was collected by personal interview or telephone survey.

Eligibility criteria:
inclusion criteria: 18 years and older no any type of complication after surgery no difficult to drink, eat or take medicaments exclusion criteria: any surgical complication previous gastrointestinal surgery schizofrenia
icg angiography in amniotic membrane graft and conjunctival autograft after pterygium excision

Conditions: Pterygium

Summary: to evaluate graft vascularization and compare the vascularization patterns of conjunctival autografts with amniotic membrane grafts to better understand the factors involved in pterygium recurrence.

the vascularization and perfusion of conjunctival autografts and amniotic membrane grafts after surgery may have significance in terms of pterygium recurrence and progression. fluorescein angiography of the anterior ocular segment has been used to evaluate ocular inflammation in scleral inflammation. however, when fluorescein is used, the quality of the angiograms is limited by rapid extravasation of the dye due to diffusion through the fenestrated capillaries of the conjunctiva and episclera. because fluorescein has a low molecular weight and is not a protein bound molecule, patchy leakage during the first transit of the dye, which obscures the angiographic details even before the late phases of the angiogram, can be seen. in contrast, indocyanine green (icg) is a larger molecule than fluorescein and is more highly found in protein bound form. therefore, it remains within the fenestrated vessels and shows negligible extravasation, which makes it ideal for use in anterior segment angiography. tan and coworkers have shown that the morphology of pterygium recurrence inevitably reflects a high degree of vascularity. in this prospective study, we evaluated the anterior segment indocyanine green angiography (icga) findings for graft vascularization after primary pterygium excision with lcat or amt.

Eligibility criteria:
inclusion criteria: * patients who had primary pterygium exclusion criteria: * patients with major systemic diseases (eg, diabetes), vascular disease (excluding hypertension), serious ocular surface disease (eg, cicatricial pemphigoid), glaucoma and previous history of ocular surgery * patients with pterygia of both eyes

Keywords: conjunctival autografts amniotic membrane indocyanine green angiography pterygium surgery
systane® complete preservative free lubricant eye drops

Conditions: Dry Eye

Summary: the purpose of this post-market clinical follow-up (pmcf) study is to assess the performance and safety of systane complete preservative free (pf) lubricant eye drops in subjects experiencing dry eye symptoms. statistical analyses will be presented overall and by dry eye disease (ded) group.

subjects will participate in the study for approximately 30 days, with a screening/baseline visit scheduled on day 1, a phone call scheduled on day 15 ± 2 (visit 2) and a follow-up visit scheduled on day 30 ± 2 (visit 3). subjects will be asked to complete the impact of dry eye on everyday life - symptom bother \[ideel-sb\]) questionnaire on day 1 and visit 3. in addition, subjects will be instructed to document systane complete pf dosing information on a daily basis using a subject diary.

Eligibility criteria:
inclusion criteria: * subject must be able to understand and sign an informed consent form * subject with mild to moderate dry eye * other protocol-defined inclusion criteria may apply exclusion criteria: * has suffered any ocular injury to either eye in the past 3 months prior to screening. * has undergone any other ocular surgery (including intraocular surgery) within the past 6 months or has any ocular surgery planned during the study. * other protocol-defined exclusion criteria may apply
fascia iliaca versus quadratus lumborum block for pain management in total hip replacement.

Conditions: Postoperative Opioid Requirements in Patients With Traumatic Fracture Hip

Summary: postoperative analgesia is essential for early ambulation of patients with hip arthroplasties as well as decreasing hospital stay time. fascial plane blocks are emerging as a gold standard for postoperative analgesia instead of opioids and nsaids, with all there side effects. the investigators aim to compare postoperative pain levels and opioid analgesic needs of fascia iliaca block versus quadratus lumborum block in patients undergoing primary total hip arthroplasty under general anesthesia.


Eligibility criteria:
inclusion criteria: * all patients aging between 40-60 years asa ii, iii with no known hypersensitivity for local anesthetics exclusion criteria: * patient refusal * known allergy to local anesthetics * previous femoral artery surgery * local infection at the site of injection * those on anticoagulation therapy

Keywords: opioid requirements
pulmonary function at presentation and follow-up in hemato-oncology 3-7 years old children

Conditions: Acute Lymphoblastic Leukemia; Acute Myeloblastic Leukemia; Solid Tumors,; Hodgkin's Disease; Non-Malignant

Summary: the aim of this study was to investigate the occurrences of respiratory symptoms risk factors and abnormalities in lung function in young children (3-6 years old) with hemato-oncologic diseases at presentation (before treatment) and up to 3 years follow-up (study period).

pulmonary function tests (pfts) are a part of the routine follow-up of patients receiving anti-cancer treatment. treatment is frequently associated with diverse pulmonary damage which may become functionally and clinically evident many years later. pfts may help to quantify the damage in the lungs; help to evaluate the point at which lung function deviates from normal to allow early intervention before irreversible lung damage occurs and thereby to reduce morbidity and mortality. reliable pfts in the preschool age have traditionally been difficult to perform, but recent publications have demonstrated that the majority of preschool children can produce reproducible forced expiratory flow volume (fevc) curves with proper coaching techniques. this recent development may enable studying the long term effect (years) of treatment on lung function in young children suffering from hemato-oncologic diseases.

Eligibility criteria:
inclusion criteria: * all pediatric patients (age 3-7 years) with hemato-onclogic diseases that were treated at the hemato-oncology department, and were sent to the pediatric pulmonary unit.

Keywords: acute lymphoblastic leukemia long-term lung function
cardiovascular changes in infants of preeclampsia mother

Conditions: Pre-Eclampsia

Summary: preeclampsia (hypertension during pregnancy) is a common problem affecting 2-8% of pregnancies worldwide and is typically diagnosed by increased blood pressure and proteinuria. the rate of preeclampsia has increased since the 1980s with higher rates at extreme maternal ages as well as during the first pregnancy. pre-eclampsia is a serious hypertensive disorder of pregnancy affecting outcomes for both mother and infants. these infants not only have increased risk of neonatal complications including preterm birth, intrauterine growth restriction, abnormal doppler parameters, feed intolerance, intestinal problem, poor growth, and long term lung condition but also have increased risk of cerebral palsy, abnormal neurodevelopmental outcomes, cardiovascular disease, stroke, and mental disorders during childhood and adulthood.

preeclampsia is diagnosed according to the international society for the study of hypertension in pregnancy (isshp) criteria: bp \> 140/90 on two occasions in previous normotensive mother after 20 weeks of gestation and one of the following; proteinuria in urine \> 0.3 gram/kg/day or acute kidney or liver dysfunction or signs of uterine dysfunction. the onset of preeclampsia can be early before 34 weeks of pregnancy (early-onset preeclampsia) or late after 34 weeks of pregnancy (late-onset preeclampsia). early-onset preeclampsia, especially between 28-32 weeks gestation, is characterized by a high prevalence of microvascular changes in the placenta that makes mothers and their infants are more liable to complication. the pathogenesis of preeclampsia is unclear. preeclampsia affects hematopoiesis and the fetal myeloid lineage leading to thrombocytopenia, neutropenia, decrease phagocytic function, decrease t regulatory cells, and an increase in cytotoxic natural killer cells in neonates. innate and adaptive immunity are regulated by myeloid cells and the immune changes in infants of preeclampsia mothers could lead to increased incidence of neonatal sepsis and the development of chronic inflammatory conditions.

Eligibility criteria:
inclusion criteria: * infants born from pregnant women with preeclampsia, their mother willing to give consent. exclusion criteria: * 1-infant with a major heart problem. * infants with major congenital and genetic anomalies.
the role of macular pigment in patients with age-related macular degeneration

Conditions: Age Related Maculopathy

Summary: in the industrialised world age-related macular degeneration (armd) is the leading cause for legal blindness beyond the age of 50 years. recent studies indicate that the amount and status of the macular pigment (mp) may play a central role in the development and progression of the disease. it has been demonstrated that the mp density can be increased by dietary supplementation. first results of mp density measurements with a modified confocal laser scanning ophthalmoscope show that this method allows to quantify the mp in a clinical setting. the aim of this study is to assess the peak mp density as well as the mp distribution in relation to the risk for armd. we will establish reference values for mp density distribution in a normal population and compare these to values obtained from patients with age related maculopathy in a cross-sectional study. for all mp density measurements we will use a modified scanning laser ophthalmoscope and dietary intake of macular pigment will be assessed using a food frequency questionnaire. clinical examinations will include etdrs visual acuity, binocular ophthalmoscopy, colour fundus photography and autofluorescence imaging. the results of our study will help assess the relationship of macular pigment density and distribution with armd. additionally, we will be able to identify patients with low mp density, and probably improve the early diagnosis of patients at high risk for developing armd. this will be the basis for dietary supplementation of lutein and/or zeaxanthin in patients with high risk for armd due to low macular pigment values.


Eligibility criteria:
inclusion criteria: * age related maculopathy exclusion criteria: * other macular diseases

Keywords: age related maculopathy, macular pigment
cardiac rehabilitation for the patients with acute myocardial infarction

Conditions: Acute Myocardial Infarction

Summary: the benefits of cardiac rehabilitation include improving exercise tolerance and quality of life. however the attending rate of the patients with acute myocardial infarction was low according to the previous studies. this is a retrospective chart review study collecting the basic characteristics of the patients diagnosed with acute myocardial infarction of wang-fang hospital (from jan 1, 2012 to june 30, 2021). the aims of the studies are to investigate the related issues of cardiac rehabilitation including (1) attending rate (2) the efficacy of exercise training (3) the factors that limit the participation of the training programs.


Eligibility criteria:
inclusion criteria: 1. cased diagnosed with acute myocardial infarction at emergent department and admitted 2. age over 20 years old exclusion criteria: 1. aad cases after admission to er or the general ward 2. cases died within admission. 3. cases refused the treatments.-

Keywords: acute myocardial infarction cardiac rehabilitation
multidisciplinary digital therapeutics of chronic lower back pain versus usual care

Conditions: Chronic Low-back Pain

Summary: this randomized controlled pilot study will be evaluating an app, mort-lbp app (eth-02k), owned by everex, inc., to examine safety and efficacy in individuals with chronic lower back pain.

this randomized controlled pilot study will enroll 46 participants, where half will be randomly assigned to the app, mort-lbp (n = 23), and half will be assigned to treatment as usual (tau) (n = 23), to examine safety and efficacy in individuals with chronic lower back pain. all subjects will be followed up in the study for a total of 12 weeks, 8-week courses of treatment with additional 4-week observation. the app provides multidisciplinary rehabilitation treatment, a combination of graded exercise therapy and cognitive behavioural therapy for patients with chronic lower back pain.

Eligibility criteria:
inclusion criteria: * male or female ≥ 19 and \<65 years of age * patients who have a history of lower back pain persisting for longer than 12 weeks * patients who have average back pain score of 3 or more on the numeric rating scale (nrs) * patients who can use application-based therapy with his/her smartphone * patients who signed a written informed consent form * patients who are able to comply with the plan, as determined by the study investigator. exclusion criteria: * patients who have previous history of spinal surgery * patients who have previous history of spinal trauma within 3 months * patients with lower extremity radicular pain with sensory and motor dysfunction * patients with lower extremity muscle strength of 3 or less on a manual muscle test * patients with spondylolysis or spondylolisthesis * patients with other structural abnormalities of the spine, including scoliosis (cobb's angle \> 10 degrees) or kyphosis (lordotic angle \< 0 degrees) * patients with red flag signs (paralyzing symptoms such as fecal impairment, sudden unexplained weight loss) * patients with tumors, infections, metabolic bone disease, cognitive impairment, fibromyalgia, and systemic inflammatory diseases * patients with other systemic disease conditions that limit exercise therapy, as determined by the study investigator * patients who are pregnant or breastfeeding * patients with known substance/alcohol use disorders * patients who are not able to participate in an exercise or strengthening program * patients taking opioid analgesic medications with a potency greater than or equal to tramadol for other conditions or low back pain
intermedius genicular nerve in the treatment of patients with chondromalacia patella

Conditions: Chondromalacia Patellae

Summary: radiofrequency application is a treatment method that temporarily prevents the transmission of pain in the nerve where the application is made through the heat emitted by radio waves.partial inhibition of the functions of the nerves carrying the joint pain sensation with this method is the basis of the treatment.the intermedius genicular nerve carries the sensation of subpatellar pain due to chondromalacia.in this study,investigators aim is to investigate the effect of radiofrequency neurotomy applied to the intermedius genicular nerve, which receives the sensation of the patella, on pain and knee function in patients with a diagnosis of chondromalacia patella who have anterior knee pain that does not resolve despite conservative treatment, under the guidance of ultrasonography.

the study was designed as prospective, randomized, controlled trial. 46 people who met the inclusion criteria were randomized into two groups of 23 people. the first group will be designated as nerve blockage group and nerve blocking program will be applied to these patients. patients in the second group will be designated as the radiofrequency group and radiofrequency ablation after the blockade program will be applied in accordance with the radiofrequency ablation protocol.participants were evaluated with visual analogue scale (vas), patello femoral pain severity scale (pfpss), kuala's patellofemoral scoring system (kpss).

Eligibility criteria:
inclusion criteria: * male/female aged \>18 years * diagnosis of chondromalacia patella after physical examination and mr imaging * those whose symptoms persist for \>3 months * participating in the study voluntarily exclusion criteria: * pregnant patients * history of previous knee surgery * to have received physical therapy from the knee area in the last 6 months * previous rf treatment or any therapeutic injection of the knee such as steroid, hyaluronic acid within 3 months * those with pain radiating from the waist or hip * patients with neuropathic pain * history of tumor, infectious, psychiatric disease, bleeding diathesis * history of knee trauma in the last 6 months * those with systemic diseases such as hepatitis, coagulopathy * patients with bmi \>40 * finding a leg length difference

Keywords: radiofrequency neurotomy knee pain ultrasound
clinical evaluation of stability of dental implant placed simultaneously with closed sinus lifting using hydraulic lift technique versus summer's osteotome technique in posterior edentulous maxilla (rct)

Conditions: Evaluations, Diagnostic Self

Summary: clinical evaluation of stability of dental implant placed simultaneously with closed sinus lifting using hydraulic lift technique versus summer's osteotome technique in posterior edentulous maxilla (rct)

clinical evaluation of stability of dental implant placed simultaneously with closed sinus lifting using hydraulic lift technique versus summer's osteotome technique in posterior edentulous maxilla (randomised clinical trial)

Eligibility criteria:
inclusion criteria: * edentulous patients in the maxillary posterior region. * patients in need to fixed restorations in posterior region. * patients with healthy systemic conditions. (apparently medically free) * patients with adequate inter-arch space for placement of the prosthetic part of the implant . * patients who had approximately 5-8 mm of available bone height between crest of bone and floor of sinus * both sexes. * patients with good oral hygiene * patients more than 20 years old * cooperative and motivated patients exclusion criteria: * patients with local pathological defects related to posterior maxilla. * heavy smokers. * abnormal habits that may alter results such as alcoholism or parafunctional habits. * patients with systemic diseases that may affect normal healing. * patients with psychiatric problem * patients with history of recent radiation therapy to the head and neck area. * patients with aggressive periodontitis.