Kornimate/medical-research-clean huggingface dataset:
comparaison of two prone position techniques on occurence of pressure sores in icu

Conditions: Acute Respiratory Distress Syndrome; Pressure Ulcers Stage III

Summary: acute respiratory distress syndrome (ards) is a diffuse inflammation of the lungs that occurs in a variety of diseases. according to the berlin definition, ards is characterized by diffuse lung damage in patients with predisposing factors. understanding the physiology of ards has led to improved ventilatory management, which must be protective to ensure adequate oxygenation and co2 clearance. prone position (pp) is a technique that can reduce mortality in patients with severe ards. pp results in a more homogeneous distribution of pulmonary stress and strain, helping to protect the lung against ventilator-induced lung injury (vili). it also increases the pao2/fio2 (p/f) ratio, improves the pulmonary ventilation-perfusion ratio, decreases paco2 and promotes ventilation of the dorsal lung regions. this technique should be offered to all patients with severe ards for 16 consecutive hours, to improve survival and weaning success from mechanical ventilation. however, pp has adverse effects. a meta-analysis showed an increased risk of pressure sores, possibly linked to generalized acute inflammation associated with significant cytokine discharge and diffuse lesions of the vascular endothelium. pp also increased the risk of obstruction and displacement of the endotracheal tube. final positioning in pp, (i.e., the position imposed on the patient for the duration of the pp session) varies from one icu to another, and is rarely described in scientific articles. there are two main variants: 1. prone , with arms alongside the body 2. prone, swimmer's position the aim of our study is to show that the "swimmer" pp reduces the occurrence of stage 3 or higher pressure sores, compared with the "arms alongside the body" pp (standard care) at day 28 post inclusion.


Eligibility criteria:
inclusion criteria: * intubated patient on invasive mechanical ventilation with moderate to severe acute respiratory distress syndrome according to the berlin classification with a p/f ratio \< 150, requiring prone position. * express consent of the patient or representative or in the absence of this, emergency inclusion procedure * health insurance coverage exclusion criteria: * patient with 2 (or more) prone position sessions * patient in whom one of the two positions could not be achieved: (joint limitation; neck size that would prevent head rotation; orthopaedic spinal or segmental trauma; bmi greater than 45) * presence of stage 2 or higher pressure ulcers on the anterior parts of the body at screening * presence of extracorporeal membrane oxygenation (ecmo) * patient already included in the study * pregnant or breastfeeding woman * patient under legal protection

Keywords: ards pressure sores pressure ulcer acute respiratory distress syndrome prone position swimmer position
rct for the efficacy of soothing cream jel in improving upper limb pain and motion

Conditions: Upper Extremity Problem

Summary: this is a randomized, double-blinded, placebo-controlled clinical trial. this trial is used to evaluate the efficacy of soothing cream jel on chronic upper limb pain and the range of motion.

potential subjects will be screened according to the eligibility criteria after signing the informed consent form. subjects who fulfill the requirements will be randomized into either the treatment group or the placebo group. and receive either soothing cream jel or placebo cream jel for 2 weeks. then followed by a post-treatment for 2 weeks.

Eligibility criteria:
inclusion criteria: 1. age 18-60; 2. participates in regular physical activity, at least once a week for 30 minutes; 3. chronic pain in the shoulder or elbow longer than 3 months; 4. 11-items numeric pain rating scale ≥4; and 5. willing to provide written informed consent. exclusion criteria: 1. the patient had received previous physiotherapy, acupuncture, tui na massage, or bone-setting treatment for distal upper limb pain within the past 2 weeks; 2. the pain was due to a fracture or known complex regional pain syndrome. 3. history of upper limb surgery; 4. known severe medical conditions (e.g. rheumatoid arthritis, osteoporosis, cardiac, renal, hepatic, hematological diseases, vertigo, seizure, infection, malignancy, neurological impairment); 5. concomitant drugs of nsaids, any kind of painkillers, or anti-inflammatory drugs 15 days prior to randomization; 6. known impaired hematological profile and liver / renal function; 7. known allergic history to any topical cream; 8. known pregnant or lactating; or 9. unable to complete questionnaires
randomized controlled pilot trial of dash feeding in older low socioeconomic adults without heart failure

Conditions: Heart Failure; Heart Failure With Preserved Ejection Fraction

Summary: this is a study of the dash diet (dietary approaches to stop hypertension) in the exploration of effective strategies for heart failure (hf) with preserved ejection fraction (hfpef) prevention.

this is a feasibility pilot, randomized clinical trial (rct), dash diet feeding trial in 40 older adults. it will also elicit trends in left ventricular remodeling and pathophysiology. this trial investigates the feasibility of performing a dash diet rct intervention in hfpef prevention in older adults of low socioeconomic status (lses).

Eligibility criteria:
inclusion criteria: * participants will have an education level of less than college as a surrogate marker of lses. exclusion criteria: * participants should not have a diagnosis of heart failure or loop diuretics on their medication list in the ehr or symptoms of dyspnea, edema (assessed via questionnaire) * poorly controlled diabetes mellitus ( hba 1c \>9%) * or uncontrolled hypertension ( sbp\>180, dbp\>110) * cardiovascular event (mi, stroke, hf, angina, atrial fibrillation) within the previous six months * chronic diseases that might interfere with participation (dementia, schizophrenia, dialysis or transplant recipient patients) * body-mass index (the weight in kilograms divided by the square of the height in meters) of more than 35

Keywords: dash diet low socioeconomic status hfpef
the primary care obesity network (pcon): incorporating principles of self-regulation of intake

Conditions: Self-regulation

Summary: in response to the high prevalence rates of childhood obesity in central ohio, the center for healthy weight and nutrition (chwn) established the primary care obesity network (pcon); a partnership between primary care physicians and nationwide children's hospital's center for healthy weight and nutrition, a tertiary care obesity center, the first of its kind in ohio. the overall goal of pcon is to bring an effective and user friendly obesity management program to the community physician's office to prevent and treat the growing number of obese children in the setting of the private office. the predominant nutrition messaging approach to tackling childhood obesity has revolved around the food choices and portion sizes. while this is relevant, an area with significant potential for impact for maintaining optimal growth and a healthy weight for young children is addressing feeding behaviors and self-regulation of intake;. - the "how" of eating. the investigators objective it to investigate whether this self-regulation approach can be employed for an older age group of 6-11 years old.


Eligibility criteria:
inclusion criteria: * mother of a 6-11 year old child exclusion criteria: * unable to speak and read english
comparison of septal and apical pacing sites in permanent right ventricular pacing

Conditions: Atrioventricular Block

Summary: the septal-pm study is aimed to compare the right ventricular apical and right ventricular septal position of the right ventricular lead in patients implanted with a pacemaker for conventional anti-bradycardia pacing indications requiring permanent right ventricular pacing ; the primary endpoint is the evolution of the left ventricular ejection fraction assessed by contrast echocardiography at 18-months follow-up.

classically the right ventricular pacing (rv) lead position is the rv apex. several small studies suggested that the septal position which provided a more physiological conduction pattern would improve left ventricular function and dimensions and the patients' outcome. the septal-pm study is a parallel randomized prospective simple-blinded and multicenter national study with a follow-up duration of 18 month. a total of 180 patients will be enrolled. it was designed to demonstrate that in patients requiring permanent rv pacing for high degree atrio-ventricular conduction disorders the septal pacing would preserve the lvef and lv dimensions but also the quality of life and the exercise tolerance. the primary endpoint is the evolution of the lvef assessed by contrast echocardiography. the secondary endpoints are: the quality of life sf 36 questionnaire, the nyha class, the 6-minute-walk test, the qrs duration, the lv end-systolic and diastolic volumes, the nt-pro bnp, mmp 2-9 and timp-1 dosages, stimulation and detection ventricular thresholds. other reported parameters are: the probes position and electric parameters, all causes of mortality, cardiovascular mortality, hospitalisations for cardiovascular causes, serious adverse events.

Eligibility criteria:
inclusion criteria: * age over 18 years old. * written informed consent. * permanent cardiac pacing indication for high degree av block with ventricular rate less than 50 bpm according to the current guidelines of the european society of cardiology . * patients with sinus rhythm or permanent atrial fibrillation. non-inclusion criteria: * indication for cardiac resynchronization. * indication for intra cardiac defibrillators (icd). * indication for av node ablation for patients with atrial fibrillation. * patients already implanted with a pacemaker or an icd. * myocardial infarction within the previous month. * surgically treated valvulopathy. * tricuspid valve prothesis * cardiac surgery or coronary revascularization planned or within the 3 last months. * life expectancy less than 18 months. * pregnancy. * disability to give informed consent.
therapeutic hypothermia after the return of spontaneous circulation

Conditions: Cardiac Arrest

Summary: the purpose of this study is to determine if induced therapeutic hypothermia (ith) in the pre-hospital setting of a four county emergency medical system (ems) that serves both urban and rural communities improves meaningful survival from medical cardiac arrest.

induction of therapeutic hypothermia after return of spontaneous circulation (rosc) in medical cardiac arrest is increasingly becoming the standard of care in the hospital setting. several studies, including two sentinel research papers in the new england journal of medicine, show improved neurologic outcome with induced therapeutic hypothermia (ith). 4, 5 this research led to a class iia recommendation by the american heart association for ith after rosc in v-fib arrest and a class iib recommendation after rosc in all other classes of medial cardiac arrest.6 the role of ith in the pre-hospital setting is less clear. studies currently exist that both show a benefit and fail to support improved outcomes.7-9 it has been suggested that the short transport times in most urban ems systems might be part of the reason that some studies have failed to find benefit of ith in the pre-hospital setting. this is a prospective, randomized controlled trial involving all patients transported by ccems who have rosc after a medical cardiac arrest and who are transported to a hospital that can continue ith for 24 hours. all comatose patients who meet inclusion criteria will be randomized to either ith in addition to continued treatment under standing protocols or regular care without ith. assignment to the two treatment arms will be done using the ems number which is generated when the ambulance is dispatched to a call. even numbered patients will have continued standard therapy while odd numbered patients will receive ith.

Eligibility criteria:
inclusion criteria: * all patient transported by ccems with rosc after a medical cardiac arrest to hospitals that can continue ith exclusion criteria: * less than 18 * cardiac arrest due to trauma or hemorrhage * pregnant women * patients whom are already hypothermic * transported to a hospital that can not maintain hypothermia for 24 hours

Keywords: pre-hospital hypothermia induced therapeutic hypothermia cardiac arrest
the impact of comprehensive medication management services on clinical outcomes in patients with cardiovascular diseases at primary care level

Conditions: Cardiovascular Diseases in Old Age

Summary: patients with established cardiovascular disease (cvd) often have multiple medications that increase the risk of prevalence of drug therapy problems (dtp), subsequently leading to unfavourable clinical and health outcomes. by providing comprehensive medication management (cmm) services to patients within a healthcare system, pharmacists assess patients' medication-related needs, identify and prevent dtp, develop individualized care plan for each individual patient and evaluate and monitor outcomes. thus, the cmm services delivered at the primary care level in collaboration with general practitioners and other healthcare providers could address this problem and by optimizing therapy improve patients' clinical outcomes and quality of life. studies have shown that patients with chronic diseases have the greatest benefit from the cmm services. the aim of this study is to evaluate the impact of cmm services on clinical and humanistic outcomes in patients with established cvd. the study will employ prospective, longitudinal, pre- and postintervention study with a 1-year patient follow-up.


Eligibility criteria:
inclusion criteria: * hypertension * established cardiovascular disease exclusion criteria: * organic, including symptomatic, mental disorders * mental and behavioural disorders due to psychoactive substance use * schizophrenia, schizotypal and delusional disorders * behavioural syndromes associated with physiological disturbances and physical factors * disorders of adult personality and behaviour * mental retardation * disorders of psychological development

Keywords: medication managements services, pharmaceutical care, primary care, elderly, control group, cardiovascular disease
preventive effect of h.pylori eradication on osteoporosis

Conditions: HELICOBACTER PYLORI INFECTIONS; Osteoporosis

Summary: in this study, the investigators observed the long-term incidence rate of osteoporosis in patients who received helicobacter pylori eradication and examined differences by age and sex.

in this study, the investigators observed the long-term incidence rate of osteoporosis in patients who received helicobacter pylori eradication and examined differences by age and sex. in addition, the investigators will analyze the correlation between the incidence of osteoporosis by comparing confounding factors such as body mass index, steroid use, and proton pump inhibitor use as well as the eradication status of h. pylori.

Eligibility criteria:
inclusion criteria: ㆍpatients tested helicobacter pylori status exclusion criteria: ㆍpatients aged \< 20 years ㆍpatients with unknown helicobacter pylori bone density status ㆍpatients with with a history of gastric cancer ㆍpatients with prior helicobacter pylori eradication therapy ㆍpatients with a history of osteoporosis

Keywords: helicobacter pylori eradication osteoporosis sex difference age
idap injection in the treatment of parkinson's disease

Conditions: Parkinson Disease

Summary: the goal of this clinical trial is to evaluate the safety, tolerability and preliminary efficacy that idap has on parkinson's disease (pd) patients.

parkinson's disease (pd) is a common neurodegenerative disease in the middle-aged and elderly. it is the "third killer" of the middle-aged and elderly after tumors and cardiovascular and cerebrovascular diseases. its main clinical manifestations are resting tremor, reduced voluntary movement, muscle rigidity, postural reflex impairment, and autonomic dysfunction, which seriously affect patients' work ability and quality of life. it is estimated that nearly 100,000 people in china become new parkinson's patients every year. experts from the world health organization predict that the number of parkinson's patients in china will reach 5 million in 2030, which will be more than half of the world's total. as the disease progresses, the symptoms of parkinson's patients will become increasingly severe. the high prevalence and high disability rate of parkinson's disease bring heavy burdens to individuals, families, and society.

Eligibility criteria:
inclusion criteria: * ages between 45 and 75 years; * diagnosed to be parkinson's disease patients according to mds parkinson's disease diagnostic criteria; * disease history 4-20 years; * hoehn and yahr stage 2-4; * stable dose of dopamine for more than 3 months; * improvement of mds-updrs part iii; exclusion criteria: * patients who have previously undergone brain surgery; * past use of stem cell therapy or participation in stem cell clinical research; * cognitive impairment; * history of mental disorders; * patients with other serious systemic diseases; * past or current metastatic malignant tumors.
dexamethasone as an adjuvant to ropivacaine for the interscalene brachial plexus block

Conditions: Postoperative Pain

Summary: shoulder surgery is associated with moderate to severe postoperative pain. interscalene brachial plexus block is considered by many as the gold standard for treating postoperative pain and consists of injecting local anaesthetics close to the nerves of the brachial plexus in the neck. duration of analgesia is between eight to twelve hours depending on the type of administered drugs. dexamethasone 4 mg is a steroid routinely injected intravenously in anaesthesia for the prophylaxis of postoperative nausea and vomiting. recently, different trials have demonstrated that combining 4 to 8 mg of dexamethasone with local anaesthetics for a perineural injection may prolong the duration of analgesia up to 24 hours. in a meta-analysis including 29 trials and 1695 patients, investigators have recently demonstrated through a meta-regression that a dose of 4 mg is sufficient and represents a ceiling dose, without neurological complications. the objective of this multicenter randomised controlled double-blinded trial is to determine the optimal dose of perineural dexamethasone. for that purpose, investigators will include a total of 150 patients divided in 5 groups: local anaesthetics with placebo, or with dexamethasone 1, 2, 3 and 4 mg.


Eligibility criteria:
inclusion criteria: * patients scheduled for elective shoulder arthroscopy * duration of surgery less than 4 hours exclusion criteria: * allergy to local anaesthetics * history of neck surgery * history of neck radiotherapy * severe respiratory disease * diabetic patient * chronic pain condition * pregnancy * patient suffering from cancer * patient with addicted disease
stories-stories to communicate risk about tobacco

Conditions: Cardiovascular Diseases; Heart Diseases

Summary: the purpose of this study is to develop and test an intervention based on literacy-appropriate electronic tools, tailored to the demographics and readiness for change of the user, to promote tobacco smoking cessation in a low-literacy population.

project stories: stories is one of two intervention trials conducted as part of the "deep south partnership for the prevention of cvd disparities" under the nhlbi partnership programs to reduce cardiovascular disparities. stories is an innovative approach to smoking cessation programs provided in medical facilities for patients seeking assistance with quitting smoking. our approach is to provide the patient with counseling prior to being discharged from the hospital in an effort to assist them with quitting smoking. the dvd will include current and previous smokers telling their stories regarding their tobacco use. we feel having the patient see other people similar to them express their views, struggles and successes with quitting smoking will motivate them to quit smoking. the patient will also receive 3 follow up telephone calls to check on their progress. our hypothesis is that patients exposed to the interactive dvd will be more likely to quit, compared with those not exposed. the specific aims for this health communication project are: (1) to develop a series of interactive, testimonial-base stage of change-matched health communication dvd video interventions targeted at low-income, low-literacy african americans in the deep south and a health information interactive dvd for the patients selected in the randomized control group; (2) to train a peer health counselor/research assistant to counsel inpatient smokers to quit and assist the community members with learning to use the dvds and then to follow-up by telephone at two weeks, three months and six months after discharge following enrollment in the project; and (3) to evaluate the impact of the intervention on processes of change and six month cessation rates among smokers using a group-randomized controlled trial. the study completion date listed in this record was obtained from the "end date" entered in the query view report (qvr) record.

Eligibility criteria:
african american inpatients receiving treatment in the medicine unit who desire to quit smoking. inclusion criteria: * african americans * patients not previously video/interviewed talking about smoking and health * patients willing to provide contact information for follow up * patients that are able to hear, view and communicate their input on material exclusion criteria: * patients other than african american * admitted with issues of alcohol, drugs, and mentally unstable * patients leaving the state after hospitalization * patients without contact information for follow up * patients below age 19 * non smokers * patients that use chewing tobacco * patients that are incarcerated
a study of chinese adults with lymphoma

Conditions: Lymphoma

Summary: the main aim of this study is to improve methods of clinical testing and therapy for lymphoma participants. this study will involve collecting information about participants from past medical records.

this is an observational, non-interventional, retrospective study to evaluate staining and interpretation concordance of cd30 expression detected by 9 immunohistochemistry (ihc) assays and ventana cd30 ihc assay in chinese lymphoma participants. this study will enroll approximately 1000 participants. the data will be collected via chart review in the electronic case report forms (ecrfs). all the participants will be assigned to a single observational cohort: • participants with malignant lymphoma this multi-center trial will be conducted in china. the overall duration of the study will be approximately 21 months.

Eligibility criteria:
inclusion criteria: 1. participants with diagnosis of chl, alcl, mf-lct, dlbcl, pmbl, enktcl, ptcl-nos, aitl and pccd30+tclpd. 2. participants with available ffpe samples archived within 3 years. 3. whose tissue slides of ffpe samples were previously ihc stained, their cd30 expression showed as well-localized positive stain and investigator deemed appropriate for evaluation. exclusion criteria: 1. sample is not sufficient for cd30 testing. 2. incomplete sample information including key demographic characteristic, clinicopathological parameters and previous cd30 testing results.

Keywords: drug therapy