Kornimate/medical-research-clean huggingface dataset:
early post-operative removal of urethral catheter in patients undergoing colorectal surgery with epidural analgesia

Conditions: Urinary Retention

Summary: patients undergoing colon or rectal surgery will usually have a urinary catheter (silicone tube) placed in the bladder at the time of operating to monitor kidney function during surgery and in the post-surgery period. such patients will also have an infusion into the spine, known as an epidural, after surgery to provide them with continuous pain relief. urinary catheters should be removed as early as possible once they are no longer required to facilitate patients becoming mobile after surgery and to reduce the risk of patients developing a urinary tract infection. traditionally these catheters are not removed until the patients epidural infusion is withdrawn, as in theory to do so would predispose the patient to developing acute retention of urine due to lack of sensation when the bladder is full. the investigators hypothesis is that urinary catheters placed via the urethra can be withdrawn 48 hours after colon/rectal surgery in patients receiving epidural pain relief without a significant increase in rates of urinary retention.

patients undergoing colon or rectal surgery will be randomly assigned to one of two groups: patients in study group 1 (sg1) will have their urinary catheters removed at 48 hours post-operatively; patients in study group 2 (sg2) will have their urinary catheters removed only after the epidural has been withdrawn in the post-operative period. we will be primarily examining rates of urinary retention in both groups. we will also be examining rates of urinary tract infection, chest infection (frequently a result of poor mobility after surgery), and wound infection and other complications after surgery.

Eligibility criteria:
inclusion criteria: * age \> 18 * competent to consent to participate in trial * undergoing colorectal surgery (any resection of large bowel, formation of colostomy, anterior resection, low anterior resection, panproctocolectomy, abdominoperineal resection). * receiving epidural analgesia post-operatively * if male, international prostate symptom score \<20. exclusion criteria: * previous lower urinary tract surgery * chronic lower urinary tract disease * intermittent self-catheterisation * neurogenic bladder * urethral catheter inserted \>24 hours pre-operatively * presence of pelvic sepsis/abscess at surgery * previous trans-abdominal pelvic surgery * urethral catheter required for urine output monitoring beyond 24 hours post-operatively * presence of enterovesical fistula * pre-operative use of medications which alter detrusor function * pregnancy
comparison between white light endoscopy and bright narrow band imaging in diagnosis colonic adenomas.

Conditions: Colonic Adenomas

Summary: removal of colorectal adenomas prevents the occurence of colorectal cancers. the use of chromo-endoscopy has been shown to improve the detection of flat adenomas. narrow band imaging enables endoscopists to accurately describe the pit pattern of adenomas. by comparing white light endoscopy and bright narrow band imaging it will show if there is any comparable advantage to using one or the other for lesion detection and assessment.

removal of colorectal adenomas prevents occurrence of cancers \[1\]. it is recognized that colonoscopy can miss colorectal adenomas and early cancers \[2\]. there is a need to further improve performance of colonoscopy. the use of chromoendoscopy has been shown to improve detection of flat adenomas \[3\]. narrow band imaging was introduced in year 2006. it is similar to chromoendoscopy in that it provides more mucosal details. this enables endoscopists to accurately describe the pit pattern of adenomas. nbi has been used as a substitute to chromoendoscopy. in pooled analysis, nbi is comparable to chromoendoscopy in their sensitivity and specificity in the diagnosis of malignant colorectal adenomas \[4\]. unfortunately, the use of nbi has not been shown to conclusively improve rate of colorectal adenoma detection. two of 3 randomized trials that compared wle to nbi showed a higher adenoma detection rate with the use of nbi \[5, 6\]. in a study by rex et al., the rate was however similar with either modality. in a pooled analysis, nbi was only marginally better than wle \[7\]. the effective use of nbi depends on the quality of bowel preparation and the experience of endoscopist. in the presence of fecal matters, nbi tends to be dark and detection of small adenomas becomes difficult. the prototype bright nbi coupled with high definition resolution is likely to overcome this drawback of original nbi.

Eligibility criteria:
inclusion criteria: * asymptomatic subjects undergoing screening colonoscopy, age \> 50, average risk subjects and, ability to provide a written consent to trial participation. exclusion criteria: * personal history of inflammatory bowel disease, colon adenoma or cancer * family history of fap or familial nonpolyposis syndrome * first degree relatives having diagnosed to have colorectal carcinoma * no colonoscopy in past 5 years
correlation between the microbiome and type 2 inflammatory diseases of crswnp

Conditions: Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

Summary: nasal microorganisms, exfoliated cells, nasal secretions, fetal microorganisms and blood were collected from patients with chronic sinusitis with nasal polyps before medication. nasal polyp tissues of the patients were clamped for pathologic biopsy in the outpatient clinic. methylprednisolone was then administered to the patients for 17 days, and the nasal microbial changes were observed after the administration of the drug. patients underwent surgical treatment after the administration of the drug, and postoperative patients were followed up for a long period of time until polyp recurrence. during the follow-up, the microorganisms in the patients' postoperative nasal cavities were collected and the postoperative microbial changes were recorded

in this study, we retrospectively collected pathologic paraffin specimens and patient information from previous cases of sinusitis with nasal polyps, and prospectively collected specimens from newly enrolled patients with nasal polyps.

Eligibility criteria:
inclusion criteria: - the diagnosis of crswnp was based on epos20201 ecrswnp was defined as eo accounting for more than 27% of the total infiltration subjects undergoing septoplasty due to anatomical variations served as controls discontinuation of steroid (oral or aerosol) and antileukotriene therapy for at least 4 weeks prior to biopsy or surgery exclusion criteria: - exclude patients with a diagnosis of posterior maxillary sinus polyps, cystic fibrosis, allergic fungal sinusitis, primary ciliary dyskinesia, allergic rhinitis, immune deficiency, or coagulopathy exclusion of patients with aspirin intolerance (aerd) exclude smokers exclude pregnant women healthy volunteers: only patients with deviated septum without any other nasal diseases served as a control group, and the participants in this group were not treated with corticosteroids and went in for septal correction. the rest of the criteria were the same
imaging tau in alzheimer's disease and normal aging

Conditions: Alzheimer Disease

Summary: this study is being done to learn about tau tangles in alzheimer's disease. a type of positron emission tomography (pet) scan is used to measure the abnormal accumulation of protein called tau in the brain. these are thought to be involved in alzheimer's disease. the investigators will also perform brain mri and to tests to measure the participant's memory and thinking.

this study is being done to determine the relationship between tau tangles and cognitive impairment in elderly subjects with and without alzheimer's disease (ad). subjects will undergo screen that includes neuropsychological testing and brain mri. this study uses a special type of scan called a pet scan to take pictures of the brain. during the pet scan, a special radioactive dye called 18f-mk-6240 is injected into the body. 18f-mk-6240 sticks to abnormal tangles made of the protein tau. subjects will have the option to have lumbar puncture performed to measure csf concentrations of biomarkers.

Eligibility criteria:
inclusion criteria: 1. age 50 and older. 2. meet criteria for either 1. amnestic mild cognitive impairment (mci) (single or mixed domain) or mild alzheimer's disease (ad), or 2. have no cognitive impairment, based on history, exam, neuropsychological testing, and consensus diagnosis. mci and mild ad patients must have clinical dementia rating scale score of 0.5 or 1. unimpaired subjects must have clinical dementia rating scale score of 0. 3. subjects unable to provide informed consent must have a surrogate decision maker. 4. written and oral fluency in english or spanish. 5. able to participate in all scheduled evaluations and to complete all required tests and procedures. 6. in the opinion of the investigator, the subject must be considered likely to comply with the study protocol and to have a high probability of completing the study. exclusion criteria: 1. past or present history of certain brain disorders other than mci or ad. 2. certain significant medical conditions, which make study procedures of the current study unsafe. such serious medical conditions include uncontrolled epilepsy and multiple serious injuries. 3. contraindication to magnetic resonance imaging (mri) scanning. 4. conditions precluding entry into the scanners (e.g. morbid obesity, claustrophobia, etc.). 5. history of kidney disease or presence of impaired kidney function based on laboratory tests at screening visit. 6. history of liver disease or presence of impaired liver function based on laboratory tests at screening visit. 7. participation in the last year in a clinical trial for a disease modifying drug for ad. 8. inability to have a catheter in subject's vein for the injection of radioligand. 9. inability to have blood drawn from subject's veins.

Keywords: 18f-mk-6240 cognitive impairment alzheimer's
focal radiation for oligometastatic castration-resistant prostate cancer (force)

Conditions: Prostate Cancer

Summary: this clinical trial will determine whether the addition of radiotherapy to standard of care systemic therapy improves objective progression-free survival compared to systemic therapy alone in patients with oligometastatic castration-resistant prostate cancer.


Eligibility criteria:
inclusion criteria: * subjects must have biopsy-confirmed adenocarcinoma of the prostate * subjects must discontinue any prior systemic therapies (excluding gnrh agonist/antagonists) without psa withdrawal effects if using first generation anti-androgens. luteinizing hormone-releasing hormone (lhrh) analogues must be continued if they have not undergone orchiectomy. (subjects who recently started systemic therapy for metastatic castration-resistant prostate cancer (mcrpc) are eligible to enroll if new therapy was started ≤ 14 days to consent date.) * subjects must have progressive metastatic castration-resistant prostate cancer based on at least one of the following criteria while having castrate levels (\<50 ng/dl) of testosterone: * a) psa progression defined as a 25% increase over baseline value with an increase in the absolute value of at least 2.0 ng/ml that is confirmed by another psa level with a minimum of a 1-week interval. * b) progression of bidimensionally measurable soft tissue or nodal metastasis by ct scan or mri based on recist criteria * c) progression of bone disease on bone scan as defined by two new lesions arising * subjects must have oligometastatic prostate cancer, defined as between 1 and ≤5 treatment sites that can be treated within a radiotherapy treatment field. * subjects must be medically fit to undergo radiotherapy and systemic therapy as determined by the treating physician. * age ≥ 18 * ecog ≤ 2 (eastern cooperative oncology group scoring system used to quantify general well-being and activities of daily life; scores range from 0 to 5 where 0 represents perfect health and 5 represents death) * no prior invasive malignancy in the past 3-years. exceptions include non-melanomatous skin cancer and in situ cancers of the bladder or head and neck are permissible. * subjects must freely sign informed consent to enroll in the study. * subjects must use contraception up to 90 days after last drug dose. exclusion criteria: * planned systemic therapy with radium-223 dichloride or sipuleucel-t * tumor requiring emergent radiation in view of provider * life expectancy estimate of \<3 months * presence of known parenchymal brain metastasis * uncontrolled intercurrent illness * inability to undergo radiotherapy, systemic treatment, cts or bone scans * biopsy proven pure small cell or neuroendocrine prostate cancer
feasibility of use of baricare app in pre-transplant population

Conditions: Obesity; Pre-Renal Transplant Candidate; Pre-liver Transplant Candidate

Summary: this current study aims to evaluate the efficacy of engagement modules in assisting patients who are candidates for renal and liver transplantation make significant lifestyle modifications. with the help of the center for innovation (cfi), a smartphone app (android and ios compatible) has been created to assist in both educating and engaging patients to develop and maintain healthy lifestyle modifications. our goal is to create a cost-effective, smartphone-based platform that serves to not only efficiently educate but to also verify competence and keep our patients engaged.


Eligibility criteria:
inclusion criteria: 1. individuals who are candidates for liver or renal transplant. 2. individuals who own a smartphone. 3. individuals who are obese. exclusion criteria: 1. patients with prior history of bariatric surgery. 2. patients with active psychiatric disorder. 3. patients with active tobacco use. 4. patients with active substance use (alcohol, illicit drugs, etc.)
placebo controlled study of ono2506po in the presence of riluzole in patients with amyotrophic lateral sclerosis (als)

Conditions: Amyotrophic Lateral Sclerosis (ALS)

Summary: the purpose of this study is to determine if oral treatment with ono-2506po in patients diagnosed with als, who have had onset of muscle weakness within 14 months of randomization, could lead to the slowing of decline in respiratory function, functional status, muscle strength, quality of life and survival compared with placebo group.


Eligibility criteria:
inclusion criteria: 1. diagnosis of clinically possible, clinically probable laboratory-supported, clinically probable or clinically definite als (according to wnf el escorial diagnostic criteria, revised according to the airlie house conference 1998) 2. onset of muscle weakness within 14 months randomization 3. concomitant standard riluzole therapy (50mg twice daily) exclusion criteria: 1. presence of a tracheotomy, mechanical ventilation or non-invasive ventilation 2. requirement for prescription drugs used for potential neuroprotective benefit -

Keywords: ono-2506po amyotrophic lateral sclerosis als
perioperative patient skin antiseptic preparation evaluation

Conditions: Surgical Site Infection

Summary: this study will evaluate a new topical skin antiseptic perioperative preparation and the standard of care to determine efficacy on the rates of surgical site infections of surgical patients. safety will also be assessed.


Eligibility criteria:
inclusion criteria: 1. be male or female and at least 18 years of age. 2. be able to verbalize an understanding of the consent form, able to provide written informed consent, verbalize willingness to complete study procedures, able to understand written and oral instructions in english. 3. be planning to undergo clean (class i wound) or clean-contaminated (class ii wounds) surgery. 4. expect to be available for up to 30-days after the surgery. exclusion criteria: 1. active infection or fever including evidence of infection at or adjacent to the operative site. 2. immunosuppressed. 3. kidney/liver failure. 4. immunosuppressive therapy (chemotherapy, steroids) within the previous 1 week. 5. any history of allergy to chlorhexidine or isopropyl alcohol or any other component in zuragard including citric acid, sodium citrate, methylparaben, or propylparaben, and fd\&c yellow #6.
allergy to almond in children

Conditions: Food Allergy in Children

Summary: allergy to tree nuts are frequent in children but allergy to almond is one of the less described tree nuts allergy. the main objective of our study is to determine diagnostic values of skin prick-tests and specific ige to almond in a population of children sensitized to almond and challenged in our unit from november 2013 to march 2020.

secondary objectives are * description of allergic reactions to almond (symptoms, severity) * modelisation of eliciting dose to almond in our population * evaluation of the association between atopic comorbidities and allergy to almond in children sensitized to almond * evaluation of the association between allergy to almond and the importance of skin and sige sensitization

Eligibility criteria:
inclusion criteria: * oral food challenge to almond performed in the pediatric allergy department of the university hospital of nancy from november 2013 and march 2020 exclusion criteria: * doubtful or incomplete oral food challenge to almond

Keywords: almond tree nuts atopy allergy children
qst in context with conditioned pain modulation

Conditions: Healthy

Summary: conditioned pain modulation (cpm) is a phenomenon which isn't examined enough. many factors of influence such as gender, age and psyche are already known - but the duration of such effects, their reliability and the correlation between standardized quantitative sensory testing (qst) and cpm is still unknown. in this study the investigators expect to find parameters in qst that correlate with the efficacy of conditioned pain modulation. knowing factors that indicate high or low potential cpm could help finding patients-at-risk and adapting their therapy.

conditioned pain modulation was firstly found in rats by electrical stimulation of their spinal cord and called diffuse noxious inhibitory controls. in humans such experimental settings are impossible. that is why we need two noxious stimuli for provoking such an endogenous pain inhibition. before the cpm setting begins, we will investigate our 32 healthy probands by basic qst following the protocol of dfns (german research network on neuropathic pain). this assessment helps us to create a sensory profile for every proband and to look for correlations between qst parameters and cpm efficacy. then the cpm setting follows. in our experimental design we use a test stimulus (ts) on the dominant forearm by thermode (normally 45-47°c, depending on the pain rating, we need scores \>nrs 60) and a conditioned stimulus (cs) on the other hand by cold water bath (10°c). both stimuli must be rated on the numerical rating scale (nrs) 0-100 alone and in combination. a positive effect can be seen, if the difference between ts alone and ts in combination with cs is \>0. to learn more about the duration of cpm effects we decided to repeat four qst parameters (cold detection threshold, warm detection threshold, mechanical detection threshold and mechanical pain threshold) within 30 minutes after finishing the cpm part to detect changes of time. the whole study design will be repeated 24-72h hours later to increase the test-retest-reliability.

Eligibility criteria:
inclusion criteria: * healthy probands \>18 years * right-handedness * informed consent * no chronic pain * no drugs (but oral contraceptives) * no neurological diseases * no psychiatric diseases exclusion criteria: * no informed consent * language deficits * left-handedness * not enough pain intensity by thermode or cold water bath * psychiatric disease, neurological diseases other chronic disease * chronic pain syndromes * pregnancy or lactation * permanent drug use, drug use in the last 14 days

Keywords: conditioned pain modulation quantitative sensory testing duration correlation
feasibility trial on organic fruit and vegetable consumption in primary school-children

Conditions: Obesity

Summary: the aim of this trial is to examine the feasibility of a larger-scale intervention study (regional study in schools run by the ministry of education) to increase the consumption of fruits and vegetables in schools towards reducing percentages of childhood obesity prevalence rates by at least 0.5% every two years for all children, using an organic-based healthy eating intervention package for primary school children and their parents.

pre-implementation phase: all necessary approvals (bioethics, ministry of education) for the implementation of the study will be taken. initial contacts with school directors will be done to obtain their approval. preparatory phase: contact with the parents' union will be done, to explain the aim of the study and bring them in contact with interested organic companies in order to reach an agreement for the cost of providing organic fruits and vegetables in school lunch menus. following the agreement, parents and children will be informed about the study through separate seminars for children and parents and a flyer that will be sent at home. signed consent forms will be obtained. teachers will also be taken on board and information pertaining to the overall scope and objectives of the study will be shared with them. this phase will also involve pre-testing of all the data collection tools. after pre-testing, necessary modifications will be carried out in the tools. intervention phase: at the beginning of the intervention (march 2020), a baseline questionnaire with demographic data and a food frequency questionnaire (ffq) to record the children's diet habits will be administered to parents. organic fruits and vegetables will be introduced at the school lunch menu and one workshop for children will be implemented per month. the workshops will include interactive games for children. signs will be posted in various school areas. at the end of the intervention (end of may 2020), a seminar for parents will take place in order to discuss their children's impression of the program. ffq and evaluation questionnaires (feedback on the intervention) will be administered to parents. for the control group: no intervention (usual education). school directors are contacted and their approval is requested to conduct the study that aims to assess the eating habits of primary school children. the parents will be informed about the study with a flyer that will be sent at home through school and signed informed consents will be obtained. a baseline questionnaire with demographic data and an ffq will be administered to parents about their children in march 2020. another ffq will be administered at the end of may 2020.

Eligibility criteria:
inclusion criteria: * primary school children attending the all-day school meals exclusion criteria: * no exclusion criteria are applied

Keywords: organic children school health promotion fruits vegetables