Kornimate/medical-research-clean huggingface dataset:
a multicenter study to obtain retrospective data for subjects previously diagnosed with adenovirus infection to serve as matched historical controls for study cmx001-304

Conditions: Adenovirus

Summary: the objective is data collection to determine background rates of adenovirus (adv) progression and mortality in subjects with adenovirus (adv) infection and/or disease.

the objective of this retrospective data collection is to determine background rates of adenovirus (adv) progression and mortality in subjects with adenovirus (adv) infection and/or disease.

Eligibility criteria:
inclusion criteria: * matched-control cases must be recruited from sites participating in the cmx001-304 study and meet all of the following criteria, as applicable, to be eligible for data abstraction in this non-interventional retrospective study: * age at time of transplant: ≥ 2 months * eligible matched-control subjects must meet the disease conditions of one or both of the two cohorts listed below on or after jan 1, 2004 and prior to mar 12, 2014. if subjects had more than one study-qualifying episode of these disease conditions on or after jan 1, 2004 and prior to mar 12, 2014, only the most recent qualifying episode should be included: * cohort a: allogeneic hematopoietic cell transplantation (hct) recipients who were at risk of progression to disseminated adv disease, defined as documented evidence of 1) asymptomatic adv viremia ≥ 1,000 copies/ml, increasing, or 2) localized adv infection * cohort b: allogeneic hct recipients with disseminated adv disease exclusion criteria: * prior use of bcv
evaluating the effectiveness of a new curriculum for transcultural nursing education

Conditions: Nursing Education; Cultural Competence; Cultural Sensitivity

Summary: in recent years, limited studies have evaluated the development of cultural awareness, sensitivity, skills, communication, and competence among nursing students using different models and curricula. this study aims to evaluate the effectiveness of a new internationally developed curriculum for transcultural nursing education. this mixed methods study was conducted on nursing students (n=83) who attended a transcultural nursing course from 2021-2022 during the fall semester.


Eligibility criteria:
inclusion criteria: * over 18 years of age * volunteering to participate in the research * being enrolled in the transcultural nursing course in the fall semester 2021-2022 exclusion criteria: * not meeting the criteria for inclusion in the study

Keywords: nursing students transcultural nursing nursing education cultural competence cultural sensitivity metaphor analysis
length of effect of extended release aspirin on platelets in patients with diabetes and heart disease

Conditions: Cardiovascular Disease

Summary: this study is being conducted to evaluate the safety and the length of effect on platelet build-up in the arteries of durlaza™ as compared to immediate-release bayer® aspirin 81 mg or subject's current aspirin 81 mg of choice in patients who have type 2 diabetes mellitus and cardiovascular disease or multiple risk factors of developing cardiovascular disease.


Eligibility criteria:
inclusion criteria: * male or non-lactating, non-pregnant female subjects * a history of type 2 diabetes and with history of at least one of the following: coronary artery disease, peripheral vascular disease, or ischemic stroke, along with at least 2 cvd risk factors (obese, smoker, ≥ 55 years of age, prior thrombotic event) exclusion criteria: * sensitivity to aspirin or any nsaid (nonsteroidal antiinflammatory drug), * evidence of uncontrolled or unstable cardio- or cerebrovascular disorder, * presence of uncontrolled or chronic medical illness, gi disorder or surgery leading to impaired drug absorption, clinically significant abnormal baseline ecg, history of hepatitis, malignancy within the past five years, or hiv, history of alcohol or drug abuse.

Keywords: antiplatelet antiplatelet therapy platelet turnover high platelet turnover platelet aggregation cardiovascular disease coronary artery disease diabetes mellitus
international long-term follow-up study of patients with uncontrolled hypertension

Conditions: Hypertension; Blood Pressure

Summary: the purpose of this post market clinical investigation is to further evaluate the safety and performance of the enlightn™ renal denervation system in the treatment of patients with uncontrolled hypertension.

this is a post market, prospective, multicenter, non-randomized, single arm study of the enlightn™ renal denervation system. approximately 500 subjects with uncontrolled hypertension will undergo renal artery ablation at approximately 40 investigational sites located internationally and will be followed up to five years post procedure.

Eligibility criteria:
inclusion criteria: * subject is ≥ 18 years of age at time of consent * subject must be able and willing to provide written informed consent * subject must be able and willing to comply with the required follow-up schedule * subject has office systolic blood pressure ≥ 140 mmhg at confirmatory visit * subject has a daytime mean systolic ambulatory blood pressure \> 135 mmhg within 90 days prior to procedure * subject has established hypertension (diagnosed ≥12 month prior to baseline) and is on a guideline based drug regimen at a stable and fully tolerated dose consisting of ≥ 3 anti-hypertensive medications (including 1 diuretic) or subject has a documented drug intolerance to 2 or more of the 4 major classes of anti-hypertensives (ace/arb, calcium channel blockers, beta blockers, or diuretic) and is unable to take 3 anti-hypertensive drugs. exclusion criteria: * subject has significant renovascular abnormalities such as renal artery stenosis \> 30% * subject has undergone prior renal angioplasty, renal denervation, indwelling renal stents, and/or abdominal aortic stent grafts * subject has hemodynamically significant valvular heart disease as determined by study investigator * subject has a life expectancy less than 12 months, as determined by the investigator * subject is participating in another clinical study which has the potential to impact their hypertension management (pharmaceutical/device/homeopathic) * subject is pregnant, nursing, or of childbearing potential and is not using adequate contraceptive methods * subject has active systemic infection * subject has renal arteries with diameter(s) \< 4 mm in diameter * subject has an estimated gfr \<15 ml/min per 1.73 m\^2 using the mdrd formula * subject had a renal transplant or is awaiting a renal transplant * subject has blood clotting abnormalities

Keywords: renal denervation renal artery enlightn™ renal denervation system renal artery ablation
fluid agitation microbiologic yield in pleural infection feasibility study

Conditions: Pleural Infection

Summary: the goal of this study is to compare the microbiologic diagnostic yield of pre-aspiration agitated pleural fluid versus that of conventionally aspirated fluid in pleural infection patients. the main question it aims to answer is, whether fluid agitation helps to increase the microbiological yield.

in pleural infection, it is suggested that the bacteria being diagnostically targeted, might more likely be residing on the pleural surface with a better blood supply and nutrition rather than being planktonic in the acidic, glucose deficient pleural fluid. the investigators thus hypothesize that an agitation of the pleural fluid prior to sample aspiration would aid in achieving a better cellular representation of the pleural space. this could have the effect of washing bacterial cells off the pleural surface as well as moving sedimented cells in the aspirated sample. this study aims to investigate whether an increase in the microbiological yield for infected pleural fluid could be achieved by a pre-aspiration agitation of the pleural fluid which would have a positive effect on management and eventual patient outcomes. adult participants with pleural infection will undergo thoracentesis via both the standard and agitated fluid techniques guided by thoracic ultrasound. microbiological yields will be compared.

Eligibility criteria:
inclusion criteria: 1. age \>18 years old 2. pleural infection based on clinical presentation, imaging or laboratory investigations and pleural fluid examination showing glucose \< 40 mg/dl or ph \<7.2 with lower respiratory infection or pus on aspiration 3. at least a moderate amount of pleural fluid collection (2 or more intercostal spaces on thoracic ultrasound) exclusion criteria: 1. minimal - mild pleural fluid deemed unsuitable for aspiration and agitation 2. hemodynamic instability 3. uncorrected coagulopathy 4. transudative or exudative lymphocytic pleural effusion on biochemical analysis
a study to assess the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of rhumab beta7 in patients with ulcerative colitis

Conditions: Ulcerative Colitis

Summary: this is a randomized , double-blind, placebo-controlled study of approximately 70 patients with ulcerative colitis.


Eligibility criteria:
inclusion criteria: * able and willing to provide written informed consent * 18-70 years of age * males and females with reproductive potential: willing to use a reliable method of contraception * diagnosis of ulcerative colitis * eligible to receive biologic therapy * disease duration of \>=12 weeks exclusion criteria: * requirement for hospitalization due to severity of ulcerative colitis * moderate to severe anemia * any manifestation of ulcerative colitis or other conditions likely to require, in the investigator's judgment, treatment with \>20 mg/day of prednisone, or prednisone equivalent, during the course of the study * pregnant or lactating * lack of peripheral venous access * inability to comply with study protocol * history or presence of contraindicated diseases * congenital immune deficiency * active or prior infection with hiv or hepatitis b or c * history of severe systemic bacterial, fungal, viral, or parasitic infections * history of any other opportunistic infections within 12 weeks prior to initiation of study treatment * received a live attenuated vaccine within 4 weeks prior to screening * hospitalized within 4 weeks prior to screening * received any contraindicated therapy within 12 weeks prior to screening

Keywords: uc ulcerative colitis
an observational study on the identification of prescription patterns of stafen cap

Conditions: Mixed Dyslipidemia

Summary: an observational study on the identification of prescription patterns of stafen cap., changes in blood lipid concentration, and statin-related muscle symptoms in korean patients with mixed dyslipidemia

this study aims to observe the effectiveness of stafen capsule such as changes in blood lipid concentration and safety including statin-related muscle symptoms, and prescription patterns under daily clinical treatment in patients who have been prescribed stafen capsules for the treatment of complex dyslipidemia.

Eligibility criteria:
inclusion criteria: 1. adults over 19 years of age 2. a patient diagnosed with mixed dyslipidemia 3. a patient who was first prescribed a stafen cap. for the purpose of treating mixed dyslipidemia according to the clinician's judgment 4. a patient who voluntarily agreed in writing to this study exclusion criteria: 1. pregnant women, lactating women, or those planning to conceive 2. a person who is prohibited from administering the stafen cap. under the permit 3. if the person in charge of other clinical studies and the person in charge deems it inappropriate to be the subject of this clinical study
finger movement training after stroke

Conditions: Stroke

Summary: human development as a species has been strongly associated with the ability to dexterously manipulate objects and tools. unfortunately, current therapy efforts typically fail to restore fine manual control after stroke. the goal of this study is to evaluate a new intervention that would combine targeted electrical stimulation of selected nerves with use a soft, pneumatically actuated hand exoskeleton to enhance repetitive practice of independent movements of the fingers and thumb in order to improve rehabilitation of hand function after stroke. the investigators will recruit stroke survivors in the subacute phase of recovery (2-18 months post-stroke). these participants will be involved in a 5-week intervention involving 15 training sessions. during these sessions, participants will train independent movement of the digits of the paretic hand. evaluation of motor control of the paretic hand will occur prior to initiation of training, at the midpoint of the training period, after completion of training, and one month later.


Eligibility criteria:
inclusion criteria: * a single, unilateral stroke 2-18 months prior to enrollment * moderate to mild hand impairment, as determined by a rating of stage 4-6 on the stage of hand section of the chedoke-mcmaster stroke assessment * visual capacity to discern specific shapes on the computer screen * capacity to provide informed consent exclusion criteria: * rigid contractures in the joints of the upper limbs, or orthopedic issues precluding joint movement * hemispatial neglect (as assessed by the behavioral inattention test) * excessive pain in the paretic upper limb (visual analog scale of shoulder pain \< 70)

Keywords: stroke fes virtual reality rehabilitation
nutrition support on outcomes and cost-effectiveness for patients at risk

Conditions: Malnutrition; Nutritional Risk

Summary: 1. the aim of this large scale study to survey the prevalence of nutritional risk and malnutrition in china,europe and usa. 2. the impact of nutritional support for the patients at nutritional risk on clinical outcomes and cost-effectiveness already get the approval by ethics committee of peking union medical college and johns hopkins hospital.

although it was often to hear that malnutrition ratio in aisa hospitalized patient was 40%-70% , there was no evidence to elaborate the prevalence of nutritional risk and malnutrition on hospitalized patients of asia. also in usa no data for nutritional risk. in 2002, scientists group headed by kondrup from : european society for parenteral and enteral nutrition demonstrated that randomized controlled clinical trials showed patients may get benefit from nutrition support when they with nutrition risk. based on these evidences, a simpler method was established by european society for parenteral and enteral nutrition in year 2002 in munich \& it was demonstrated useful to evaluate the appropriate use of nutrition support at present time. this method was named as nutrition risk screening (nrs). we propose to survey the prevalence of malnutrition \& nutrition risk in large cities' large/middle size hospitalized patients in china, europe and usa use nrs tool. as well, we also aim to figure out the current nutrition support status in current large/middle size hospitals through this survey. we also propose to evaluate the cost-effectiveness of parenteral nutrition, enteral nutrition and non-nutritional support, and to examine the clinical outcomes of nutritional support in certain patients at nutritional risk identified by nrs-2002. for international cooperation,our partners are professor kondrup of europe and professor nolan from johns hopkins hospital,there are students from a cooperative project with johns hopkins hospital for doctor of philosophy students 2005-2011. in plan this protocol might be completed around 2016 also.

Eligibility criteria:
inclusion criteria: * patients be in hospital overnight * diagnoses according to the protocol of cohort study for cost effectiveness exclusion criteria: * patients admitting from emergency department * patients who undergone operation before second morning of hospitalization * patients who dose not give informed consents

Keywords: nutritional risk screening(nrs) malnutrition overweight obesity clinical nutritional support clinical outcome cost effectiveness complication infective complications
creating welcoming faith communities for people with serious mental illnesses

Conditions: Other

Summary: the goal of this intervention study is to test a behavioral intervention to increase inclusionary practices toward individuals with serious mental illness in faith communities. the main questions it aims to answer are: 1. to determine if the behavior-based intervention leads to an increase in inclusionary practices (e.g., conducting outreach with mental health agencies). 2. to determine if the behavior-based intervention is effective in increasing inclusive practices by members and leaders of faith communities. 3. to determine if the intervention leads to a greater understand of mental illness and a decrease in stigmatizing beliefs by congregation members. 4. to determine if the intervention results in individuals with serious mental illness and their family members reporting less discrimination and increased inclusion. congregations will be asked to create an inclusion committee that will then work on developing systems and changing congregational practices to become more inclusive. all congregation members will be invited to a half-day training that will provide information on mental illness and inclusion, and will provide tips and strategies when they encounter situations or behaviors that are less familiar to them. all congregation members will be given the opportunity to participate in a survey about congregational practices.


Eligibility criteria:
inclusion criteria: * member or attendee of the faith community participating in the training exclusion criteria: * under the age of 18

Keywords: inclusion stigma reduction faith communities
a study in healthy subjects to assess how dosing of rifampin affects what the body does to a dose of gw679769 (casopitant).

Conditions: Nausea and Vomiting, Chemotherapy-Induced

Summary: this study will examine what the body does while taking gw679769 alone and together with rifampin in healthy adult subjects.


Eligibility criteria:
inclusion criteria: * healthy * female subjects who cannot become pregnant * able to swallow and keep down oral medication * can understand and follow the protocol requirements and instructions exclusion criteria: * smokes at least 4 packs per day in the past 12 months * use of prescription or non-prescription drug(s) * herbal or dietary supplements or vitamins with 14 days prior to first dose of study medication * a clinically relevant abnormality medical condition or circumstance making the subject unsuitable for the study per the study doctor * blood donation in excess of 1 pint within 56 days before dosing of medication * iron deficient * history or drug allergy of study medication * history of drug or alcohol abuse or dependency within the past 6 months * subjects cannot use any nicotine-containing products within the last 6 months * positive for hiv, hepatitis b or c * active peptic ulcer disease * uncontrolled nausea and vomiting * active infection * heart failure * female who is lactating * female who has a positive pregnancy test

Keywords: rifampin gw679769
covid-19 and acute invasive fungal rhinosinusitis

Conditions: Covid19

Summary: data for acute invasive rhinosinusitis was obtained from the otorhinolaryngology departments at our tertiary hospital at the period from january 2017 to december 2020. then the risk factors of comorbid diseases and fungal types between post-covid-19 and non-covid-19 groups regarding the incidence of invasive rhinosinusitis are compared.


Eligibility criteria:
inclusion criteria: * patients of any age and sex. invasive rhinosinusoitis diagnosis based on clinical , endoscopic diagnosis * positive findings for acute sinusitis on sinus computed tomography (ct) scan in addition to fungal determination by histopathological examination of specimen of affected tissues for detection of the type of fungi. * positive pcr was confirmed from the patient's files at the isolation hospitals for covid 19 group. exclusion criteria: * patients who completed management outside our hospital

Keywords: fungal sinusitis rhinosinusitis
effect of face masks on pulmonary function in patients with copd

Conditions: COPD; Walking, Difficulty

Summary: given the heightened vulnerability of copd patients to severe illness upon sars-cov-2 infection, precautions like mask-wearing are deemed crucial. yet, mask-wearing can exacerbate breathlessness and discomfort in this demographic. this study aims to assess the effects of wearing a face mask during 6-minute-walking-tests (6-mwt) among copd patients.

in this detailed study, we aim to explore the impact of wearing face masks on copd patients during 6-minute-walking-tests (6mwt). copd, commonly observed among smokers and former smokers, poses heightened mortality risks upon sars-cov-2 infection. consequently, face masks are often recommended for preventive measures. however, breathlessness remains a predominant symptom in this patient cohort. moreover, there is a dearth of data concerning blood oxygenation levels while wearing various types of face masks. the study will involve copd patients who will undergo three 6mwts: one without a mask, one with a simple face mask, and one with a ffp2 mask. prior to each 6mwt, comprehensive pulmonary function tests including spirometry, body plethysmography, and co-diffusion capacity measurement will be conducted. additionally, capillary blood gas analysis will be performed both before the 6mwt and after each test session.

Eligibility criteria:
inclusion criteria: * copd diagnosis * vaccinated against sars-cov 2 exclusion criteria: * known cardial insufficency * long term oxgenation therapy * immobility * bmi \>35 * pregnancy
peng block for total hip arthroplasty

Conditions: Hip Osteoarthritis; Hip Arthropathy; Hip Disease; Hip Pain Chronic

Summary: this randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the pericapsular nerve group block on postoperative rehabilitation.

the pericapsular nerve group, or peng block, has been recently described and shows promise in providing analgesia to the hip joint. however, the effect of this block on postoperative rehabilitation is uncertain. this study compares a preoperative peng block to a placebo before total hip arthroplasty under spinal anesthesia. the primary outcome measure is verticalization, walking distance, ability to go out of bed, active lifting of the limb, range of motion in the hip joint, bending range of motion, and abduction range of motion. the secondary measure is postoperative pain assessment during rehabilitation.

Eligibility criteria:
inclusion criteria: * patients \> 18 years old undergoing unilateral total hip arthroplasty exclusion criteria: * refusal to participate * \< 18 yo * chronic opioid use * localized infection

Keywords: periarticular nerve group block total hip arthroplasty pain management multimodal analgesia regional anesthesia