Kornimate/medical-research-clean huggingface dataset:
preoxygenation for the intubation of hypoxemic patients: comparison of standard oxygenation, high flow nasal oxygen therapy, and noninvasive ventilation

Conditions: Adult Patients; Requiring Intubation; Hypoxemia (Defined by PaO2/FiO2( Fraction of Inspired Oxygen) Below 200); Patient Covered by French Health Care System

Summary: prospective, randomized clinical multicentric study, in icu, during preoxygenation for the intubation of hypoxemic patients.

prospective randomized clinical multicentric study in icu, comparing standard oxygenation, high flow nasal oxygen therapy and non invasive ventilation (niv) , with pulse oxymetry values (spo2), during preoxygenation for hypoxemic patients

Eligibility criteria:
inclusion criteria: * adults patients * requiring intubation and hypoxemia (defined by pao2/fio2 below 200) * patient covered by french health care system exclusion criteria: * patient refusal * intubation for other causes (excluding hypoxemia) * impossibility to measure pulse oxymetry value * contraindication for niv : vomiting * niv intolerance * cardiac arrest during intubation

Keywords: preoxygenation intubation
combating alzheimer's through sleep and exercise

Conditions: Alzheimer Disease; Dementia

Summary: the purpose of this research is to see how sleep and exercise affects dementia risk over time.


Eligibility criteria:
inclusion criteria: 1. able to perform mild exercise 2. able to wear dreem 2 headband 3. able to wear a fitbit wrist watch 4. able to perform the everlywell biomarker procedure 5. able to understand and speak english 6. able to operate a digital device like mobile phone, ipad, or computer 7. self-reported history of problems with cognitive impairment: memory, concentration, and processing information 8. only participants cognitively able and willing to provide consent will be included. exclusion criteria: 1. prohibited from or unable to perform mild exercise 2. unable to wear wrist watch or headband devices, or unable to supply pinprick blood sample for any reason 3. unable to speak or understand english 4. unable to use mobile device/smartphone technology 5. unable or unwilling to consent for any reason.
evaluation of the effect of a probiotic in patients undergoing orthodontic therapy

Conditions: Orthodontics; Dental Hygiene; Gingivitis and Periodontal Diseases

Summary: orthodontic patients need supplementary oral hygiene tools in addition to professional oral hygiene. the aim of this study is to evaluate the effects of bifidobacterium animalis subs. lactis hn019 on plaque accumulation and gingival bleeding in orthodontic patients.


Eligibility criteria:
inclusion criteria: * age range of 10 to 30 years old; * good general health; * patients undergoing fixed multibracket orthodontic treatment; * patients undergoing invisible aligner orthodontic treatment. exclusion criteria: * physical, mental or motor disabilities; * systemic conditions that influence the progression of gingivitis; * presence of non-plaque-induced gingivitis; * known allergies; * smokers (if more than 5 cigarettes per day); * use of antibiotics, anti-inflammatories, or probiotics in the 6 months prior to recruitment.

Keywords: probiotics fixed orthodontic oral hygiene clear aligners
men undergoing radical prostatectomy

Conditions: Prostate Cancer

Summary: the purpose of this study is to see if the protein pattern in your blood can predict whether or not your prostate tumor is aggressive. we will use a new and very sensitive technique, called mass spectroscopy, to measure hundreds of pieces of protein in your blood. a computer will make a picture of the protein pattern. we will do this in 500 men before their prostate surgery and see if there is a pattern that predicts what the tumor looks like under the microscope. we will also check the protein pattern in your blood 6 weeks to 12 months after the surgery to see if your pattern changes.

in this pilot study, we propose to address the question: is there a small peptide mass proteomic profile/pattern in blood that can distinguish men with a clinically insignificant/latent prostate cancer from men with more advanced pathological features? we will obtain a pre-operative blood sample from men with clinically localized prostate cancer undergoing radical prostatectomy and determine their preoperative small peptide mass proteomic profile. the pathological features of the radical prostatectomy will be determined and the patient will be classified as having either a pathologically insignificant/latent prostate cancer or a significant cancer. we will then analyze whether or not the small peptide mass proteomic profile in blood can distinguish these groups before radical prostatectomy. in addition, each of these patients will have a blood sample collected at least 6 weeks to 12 months after surgery to evaluate and compare changes that occur as a result of radical prostatectomy. this will determine the effect of radical prostatectomy on the small peptide mass proteomic profile in blood and determine if the proteomic profiles in blood collected prior to radical prostatectomy can identify men at increased risk for recurrence.

Eligibility criteria:
inclusion criteria: * men aged 18 years or older with clinically localized prostate cancer (ct1- t2nxm0) * scheduled for radical prostatectomy * prostate biopsy at least 6 weeks prior to scheduled radical prostatectomy * signed, informed consent * patient must be able to attend both the preoperative and postoperative blood draws. exclusion criteria: * a period of less than 6 months prior/current treatment with hormonal therapy (lhrh agonist/antagonist, antiandrogen, 5-alpha-reductase inhibitor). * a period of less than 6 months prior/current treatment with an alpha-blocker

Keywords: prostate cancer early prostate cancer radical prostatectomy
intra-arterial infusion chemotherapy combined with sodium bicarbonate for unresectable gastric cancer

Conditions: Successful Conversion Rate of Operation; Unresectable Gastric Cancer

Summary: this project intends to compare the clinical effects and side effects of three kinds of treatment methods in the treatment of unresectable gastric cancer by intra-arterial catheter infusion chemotherapy combined with sodium bicarbonate and systemic chemotherapy. it is clear that intra-arterial catheter infusion chemotherapy combined with sodium bicarbonate is not suitable for the treatment of unresectable gastric cancer. the clinical practice value of resection of gastric cancer can provide high quality evidence-based medical basis for the treatment guidelines of advanced gastric cancer, and explore a new clinical technology with exact curative effect and higher safety.


Eligibility criteria:
inclusion criteria: 1. patients aged 18 to 75 years; 2. ultrasound gastroscopy or imaging (ct) can diagnose potentially unresectable gastric cancer (t4a-bn2-3m0) with indications of neoadjuvant chemotherapy or transformation therapy; 3. pathological diagnosis of gastric cancer; 4. no contraindication of chemotherapy; 5. patients who did not undergo chemotherapy or were diagnosed for the first time. exclusion criteria: 1. those who fail to comply with the requirements of the trial, obviously violate this regimen, or change to other regimens in the course of treatment; 2. the life expectancy of patients with extensive systemic metastasis is less than 3 months; 3. leukocyte count is less than 2\*109/l and platelet count is less than 75\*10\^9/l; 4. severe heart, liver and kidney diseases, unable to tolerate chemotherapy; 5. patients without gastric cancer complications such as massive gastrointestinal bleeding and perforation need to be treated in emergency department; 6. patients with distant metastasis (excluding group 16 lymph node metastasis); 7. patients with other tumors, with a history of malignant tumors (excluding early primary cancers); 8. the patient himself asked to withdraw from the trial; 9. researchers believe that patients are not suitable for this study.
achilles tendinopathy treated with training and injections

Conditions: Achilles Tendinopathy

Summary: the purpose of this study is to compare in a randomized double blinded controlled trial the effect of heavy slow resistance exercises combined with ultrasound guided injections with local anesthetic with or without glucocorticosteroid in patients with achilles tendinopathy.

achilles tendinopathy is a common and often longlasting condition especially in a sports population. the highest incidence is seen in sports involving running and jumping. as the primary treatment eccentric exercises is recommended and 60-90% will benefit by that. other studies have shown equal effect of stretching exercises. in a new study heavy slow resistance exercises has proven effective in achilles tendinopathy and the best treatment in lig.patellae tendinopathy. injection with glucocorticosteroid is often used in the daily clinic, though inflammation is rarely found. fredberg 2004 found a good short term effect of glucocorticosteroid injection in an rct, but no effect in the long term, which the investigators explained by an aggressive rehabilitation with running after a few days. even though 60-90% will benefit from exercises in efficacy studies, a recent pragmatic effectiveness study by weetke 2015 found that only 26% did benefit from training alone, but if supplemented by need with 1-3 injections of glucocorticosteroid 76% achieved excellent or good result. to our knowledge no randomized clinical trials have investigated the combined effect of training and injections. the hypothesis of this study is, that training and slowly progressive rehabilitation combined with glucocorticosteroid injections will have better effect than the same training and rehabilitation combined with injections of local anesthetic.

Eligibility criteria:
inclusion criteria: * midsubstance pain in the achilles tendon * symptoms for at least 3 months * ultrasound scanning at the first visit shows thickness of the achilles tendon above 7 mm or 20% thicker than the contralateral. * patient can read and understand danish exclusion criteria: * earlier operations in the foot and leg, that is judged to complicate training * known arthritis. * known diabetes * leg ulcerations or infections in the foot. * judged unable to comply with the training protocol. * daily use of pain killers * glucocorticosteroid injection to the diseased achilles tendon within the last 6 months. * earlier allergic reactions to glucocorticosteroid or local anesthetic. * pregnancy or planning to become pregnant * bmi above 30.

Keywords: strength training, injection, glucocorticoid
comparative study of nxl103 versus linezolid in adults with acute bacterial skin and skin structure infections (absssi)

Conditions: Acute Bacterial Skin and Skin Structure Infections

Summary: the objective of this study is to evaluate the efficacy and safety of oral nxl103 vs. established treatment of acute bacterial infection in adults.


Eligibility criteria:
inclusion criteria: * diagnosed with acute bacterial skin and skin structure infection (absssi) with at least 3 signs or symptoms exclusion criteria: * uncomplicated acute bacterial skin and skin structure infections * absssi suspected or proven to be due to gram negative and/or anaerobic pathogens * pregnant or lactating women * inadequately controlled diabetes mellitus * inadequately controlled arterial hypertension * moderate-to-severe renal impairment * moderate-to-severe liver disease * conditions associated with immunodeficiency * known hypersensitivity or any contraindication for the use of any of the 2 study drugs
the role of ct chest scan in the pre-anesthetic assessment of suspected or confirmed covid -19 patients

Conditions: Covid19

Summary: the role of ct scan of the chest in pre-anesthetic assessment of the severity of covid-19 and the correlations between ct measurements of the aortic and pulmonary arteries diameters and severity of pneumonia.

patients who were scheduled for emergency surgery during covid-19 pandemic should have be screened for covid pre-operatively given the prevalence f asymptomatic or mildly symptomatic cases that could be carriers to infection and possibly cause cross infection to the operating room staff especially the anesthetists who deal with the upper airway during intubation with high possibility of getting infected with sars-cov 2 virus. waiting respiratory tract pcr (rt-pcr) test for covid can delay the surgery which may increase patients morbidity and mortality. rt-pcr test has limited sensitivity and specificity. patients who are confirmed to have covid-19 infection (have positive rt-pcr) or patients who have possible covid-19 infection (have symptoms but were not tested with rt-pcr) will undergo non-enhanced ct scanning of the chest (without giving iv contrast). chest ct scan will be interpreted by 2 consultants radiologists with an experience of at least 10 years in their field. the radiologists are going to be requested to comment on the lung parenchyma, describing the findings , assess the pulmonary artery, aorta diameters and the aorta:pulmonary diameters ratio will be then calculated. the degree of pneumonia severity index will then be described as well. the radiologists will be blinded to the aim of the study. all data will be collected and then correlation between the data sets will be statistically tested.

Eligibility criteria:
inclusion criteria: * all patients scheduled for emergency surgery with symptoms suggestive of covid-19 infection. exclusion criteria: * pregnancy. * haemodynamic instability (mean arterial blood pressure above 65 mmhg or the need for of inotropic drugs to maintain mean arterial blood pressure above 65 mmhg). * active bleeding. * any indication by the surgeon or the anesthesiologist to proceed for immediate surgery for the patient safety. * patients refusal to do ct scanning.
phase ii trial of auy922 vs. comparators in advanced gastric cancer

Conditions: Advanced Gastric Cancer; Gastro-esophageal Junction Cancer

Summary: a clinical trial to determine the effectiveness and safety of auy922 compared to other drugs known to be effective against gastric cancer in second line therapy for patients who have failed one line of chemotherapy.


Eligibility criteria:
inclusion criteria: * radiologically confirmed advanced gastric cancer * one previous line of chemotherapy * progressive disease * one measurable lesion * blood tests within protocol ranges * (who) performance status ≤ 1 * able to sign informed consent exclusion criteria: * no symptomatic brain metastases * no coumarin type anticoagulants * no liver or kidney disease * no impaired heart function * no pregnant or lactating women other protocol-defined inclusion/exclusion criteria may apply

Keywords: gastric cancer metastatic gastric cancer advanced gastric cancer
effect of hot footbath on the sleep quality

Conditions: Schizophrenia

Summary: the research title is the effect of hot footbath on the sleep quality of patients with chronic schizophrenia. the research was a randomized controlled trial. the setting was the chronic inpatient wards at a psychiatric teaching hospital in northern taiwan. a total of 63 participants, 30 in the hot footbath group and 33 in the control group, were completed the study from november 2019 to june 2020. participants were randomly allocated to the experimental group and the control group. through this method, we explored whether the trial could effectively improve patients' sleep quality.

the research title is the effect of hot footbath on the sleep quality of patients with chronic schizophrenia. the research was a randomized controlled trial. the setting was the chronic inpatient wards at a psychiatric teaching hospital in northern taiwan. a total of 63 participants, 30 in the hot footbath group and 33 in the control group, were completed the study from november 2019 to june 2020. participants were randomly allocated to the experimental group and the control group. the experimental group was given a hot footbath with a temperature of 41℃±1℃ for 20 minutes at about 1-2 hours before sleep, and this was repeated five times a week for four weeks; the control group was given routine care for four weeks. the cpsqi was used to collect the pre- and post-test data. through this method, we explored whether the trial could effectively improve patients' sleep quality.

Eligibility criteria:
inclusion criteria: 1. clinical diagnosis of schizophrenia disease. 2. having schizophrenia at least two years. 3. must have above 5 scores in the pittsburgh sleep quality index (cpsqi). exclusion criteria: 1. having the foot problems, including allergy, wound, swelling, pain, peripheral circulation, and any skeletal, muscular, or nervous lesions in the foot.

Keywords: footbath quality of sleep chronic schizophrenia patient
adaptive implementation intervention for va suicide risk identification strategy

Conditions: Suicide

Summary: the overall objective of this national quality improvement project is to develop an adaptive implementation strategy to improve the implementation of suicide risk screening and evaluation in veterans health administration ambulatory care settings (i.e., va risk id).

va risk id is the largest implementation of population-based suicide risk screening and evaluation in any united states healthcare system to date. given the considerable scope of this initiative, several strategies have been employed to support national implementation. to facilitate continuous quality improvement, ongoing evaluation of va risk id and interventions to improve implementation of the three-stage screening and evaluation process are needed. this project is intended to help vha facilities address challenges to implementing va risk id to fidelity using a sequence of evidence-based implementation strategies (audit and feedback followed by audit and feedback plus external facilitation). by doing so, it will ensure that more veterans are screened and evaluated for suicide risk, which is the basis of effective, patient-centered suicide risk management. by adapting the implementation intervention "dose" based on facility performance and monitoring implementation over time, this project will allow the program office to focus resources where and when needed the most.

Eligibility criteria:
inclusion criteria: * intervention occurs at the site/facility level. up to 140 vha facilities across the country will participate in the project. sites will be allocated to various interventions based on performance (i.e., pre-determined benchmarks for adequate implementation). exclusion criteria: * this is a national quality improvement project. sites that are randomized to different intervention arms based on performance may refuse to participate in the implementation interventions.

Keywords: prevention implementation science
automated medical record driven implantable cardioverter-defibrillator heart failure trial (america-hf)

Conditions: Heart Failure

Summary: purpose and objective: heart failure therapies including beta-blockers, ace-inhibitors, aldosterone antagonists, implantable cardioverter-defibrillator (icd) and cardiac resynchronization therapy (crt) devices have proven beneficial but are underused in eligible patients. the investigators seek to determine if automating referral to cardiologists and electrophysiologists through an intelligent electronic medical record system can improve adherence to american college of cardiology (acc)/ american heart association (aha) heart failure guideline recommended therapies. study activities and population group: the america-hf trial will be a randomized, single-center, single blinded study comparing standard-practice provider initiated cardiovascular specialty referral to experimental automated medical record driven cardiovascular specialty referral. an investigational program will automatically screen all finalized electronic reports from clinically indicated transthoracic echocardiogram studies performed in the duke university echo lab system and create an automated query to obtain hf icd-9 codes. eligible patients will be randomly assigned to participate in a registry (n=125) or automated electronic medical record (emr) based subspecialty care intervention arm (n=125). data analysis: the primary endpoint is rate of adherence (%) to acc/aha hf guideline recommended therapies at 3, 6, and 12 month follow-up among patients randomized to the registry compared to the intervention. differences in characteristics (including use of guideline recommended therapies) will be tested using pearson chi-square tests for categorical variables and wilcoxon two-sample tests for continuous variables. time to event analysis will be performed for the secondary endpoints of hospitalization or death.


Eligibility criteria:
inclusion criteria: * left ventricular ejection fraction ≤ 35% on transthoracic echocardiogram * one of the following icd-9 hf diagnostic codes 398.91, 428.0, 428.1, 428.2x, 428.3x, 428.4x, 428.9 exclusion criteria: * pregnancy * inability to speak english * inability to provide verbal consent

Keywords: heart failure medical therapy icd crt
cetuximab in treating patients with stage iv colorectal cancer

Conditions: Colorectal Cancer

Summary: rationale: monoclonal antibodies such as cetuximab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. purpose: phase ii trial to study the effectiveness of cetuximab in treating patients who have stage iv colorectal cancer that has not responded to previous treatment.

objectives: i. determine the response rate of patients with irinotecan-refractory, stage iv colorectal cancer when treated with cetuximab. ii. determine the safety and toxic effects of this drug in these patients. iii. determine the time to progression of patients treated with this drug. outline: this is a multicenter study. patients receive cetuximab iv over 1-2 hours weekly for 6 weeks. treatment repeats in the absence of disease progression or unacceptable toxicity. patients are followed at 4 weeks and then every 3 months thereafter. projected accrual: a total of 20-40 patients will be accrued for this study within 4 months.

Eligibility criteria:
disease characteristics: histologically confirmed recurrent stage iv colorectal cancer any t, any n, m1 documented progressive disease within 6 months of completing an irinotecan- containing regimen bidimensionally measurable metastatic disease meningeal or cns involvement allowed immunohistochemical evidence of egfr expression (at least 1+) patient characteristics: age: 18 and over performance status: ecog 0-2 life expectancy: not specified hematopoietic: absolute neutrophil count at least 1,500/mm3 wbc at least 3,500/mm3 platelet count at least 100,000/mm3 hemoglobin at least 9 g/dl hepatic: bilirubin no greater than 1.5 times upper limit of normal (uln) ast no greater than 5 times uln alkaline phosphatase no greater than 5 times uln renal: creatinine no greater than 1.5 times uln cardiovascular: no history of uncontrolled angina, arrhythmias, or congestive heart failure other: no other malignancy within the past 3 years except basal cell skin cancer or pre-invasive carcinoma of the cervix no uncontrolled seizure disorder no neuropathy greater than grade 2 or other neurologic disease no medical or psychiatric condition that would preclude study not pregnant or nursing negative pregnancy test fertile patients must use effective contraception prior concurrent therapy: biologic therapy: no prior murine monoclonal antibody therapy or cetuximab chemotherapy: see disease characteristics recovered from prior chemotherapy no other chemotherapy since completing irinotecan-containing regimen no concurrent chemotherapy endocrine therapy: not specified radiotherapy: at least 30 days since prior radiotherapy and recovered no concurrent radiotherapy surgery: at least 21 days since prior surgery, except diagnostic biopsy, and recovered other: at least 30 days since prior investigational agents and recovered

Keywords: stage iv colon cancer stage iv rectal cancer recurrent colon cancer recurrent rectal cancer