Kornimate/medical-research-clean huggingface dataset:
pulmonary aspergillosis in tuberculosis patients

Conditions: Pulmonary Tuberculoses; Aspergillosis; Old Tuberculosis; Active Tuberculosis; Chronic Pulmonary Aspergillosis

Summary: pulmonary tuberculosis (ptb) is the most common cause of lung destruction, contributing to coinfections development, and aspergillosis spp. is one of the most important. diagnosis of chronic pulmonary aspergillosis (cpa) in ptb patients is difficult due to similarity of clinical and radiological data, especially in resource-constrained settings. differentiation of ptb patients with singling out a group with a higher aspergillus igg level during the initial examination will help physicians to orient to further examination of cpa. objectives: to determine the prevalence of aspergillosis in koch's bacillus-positive and koch's bacillus-negative ptb patients and antifungal resistance of aspergillus species isolates in central asia countries.

chronic pulmonary aspergillosis (cpa) complicates treated pulmonary tuberculosis (ptb), with high 5-year mortality. ptb affected an estimated 10.4 million people in 2016. just 57% of ptb cases reported to the world health organization (who) were bacteriologically confirmed. cpa both complicates and mimics treated ptb. the prevalence of cpa in patients with treated tb and the contribution of misdiagnosed cpa to ptb prevalence estimates are unclear. mycological analysis of sputum for aspergillus is often negative in cpa. detection of aspergillus igg is one of the main analysis in cpa diagnosis, but until recently had been inadequately validated for use in this context. both tests are infrequently available in areas of high ptb prevalence. antifungal therapy improves survival. but, survival rates vary significantly among published studies. reported survival rates are 58%-93% at 1 year of follow-up, 17.5%-85% at 5 years of follow-up, and 30%-50% at 10 years of follow-up. in a selected group of patients with cpa, weekly subcutaneous injections of ifnγ has been shown to improve disease control and also helps with bacterial clearance. several factors have been reported to affect mortality, including by underlying pulmonary disease, advanced age, ntm infection, quality of life scores, and serum albumin levels. no data on the prevalence of cpa among patients with ptb and resistance of aspergillus spp. to antifungal drugs in uzbekistan and neighboring countries. the aim of the study is to determine the prevalence of aspergillosis in koch's bacillus-positive and koch's bacillus-negative ptb patients and antifungal resistance of aspergillus species isolates in central asia countries.

Eligibility criteria:
inclusion criteria: * pulmonary tuberculosis patients (smear-positive) * pulmonary tuberculosis patients (smear - negative) exclusion criteria: * neutropenia * severe immunosuppression caused by cancer chemotherapy * hematopoietic stem cell or solid organ transplantation * hiv infected individuals
a study to assess the safety and efficacy of mk8245 in patients with type 2 diabetes mellitus and inadequate glycemic control (mk8245-005 am2)

Conditions: Type 2 Diabetes Mellitus

Summary: a study to assess the safety and efficacy of mk8245 as monotherapy compared to placebo.


Eligibility criteria:
inclusion criteria: * have type 2 diabetes mellitus * 18 to 65 years of age exclusion criteria: * history of type 1 diabetes or ketoacidosis * have been treated with lipid lowering medications 4 weeks before starting the study * have started on a weight loss program and not in the maintenance phase or have started weight loss medication within the last 12 weeks * have had surgery in the last 30 days * history of active liver disease * history of coronary heart disease or congestive heart failure * have had a stroke or transient ischemic neurological disorder in the past 6 months * are human immunodeficiency virus (hiv) positive
a study on an immunostimulant antibody in combination with chemotherapy for advanced cancer of the pancreas

Conditions: Pancreatic Neoplasm

Summary: this study aims to seek evidence that activation of certain cells of the immune system will be safe and well tolerated in combination with cytotoxic chemotherapy. preliminary evidence of clinical anti-tumor activity will be sought.


Eligibility criteria:
inclusion criteria: * 1st-line surgically incurable cancer of the pancreas * ecog(eastern cooperative oncology group) performance status 0-1 exclusion criteria: * previous systemic therapy for pancreas cancer * history of cancer-associated blood clots * history of autoimmune disease

Keywords: pancreas cancer; cancer of the pancreas; gemcitabine; chemotherapy; monoclonal antibody; immunotherapy; cd40
trapeziectomy: internal brace vs. ligament reconstruction (prospective)

Conditions: Basilar Thumb Arthritis

Summary: this study seeks to compare two methods of trapeziectomy for basilar thumb arthritis. the first is trapeziectomy with ligament reconstruction and tendon interposition, which means removing the trapezium bone and filling the void with a tendon graft. this is the most commonly used procedure and the control group. the experimental group is trapeziectomy with suture tape suspension of the 1st metacarpal to the 2nd metacarpal. this is using a device called the internalbrace, produced by arthrex.


Eligibility criteria:
inclusion criteria: * patients of henry ford orthopedic service line * symptomatic basilar thumb arthritis refractory to conservative management exclusion criteria: * significant medical comorbidity precluding safe surgery, as determined by the operating surgeon. this may include cardiac disease, renal disease, liver disease, pulmonary disease, or heavy substance abuse. * requirement for additional procedures at the 1st carpometacarpal joint, including trapezoid excision-whole or partial-or metacarpal osteotomy. of note other existing conditions requiring intervention on a separate surgical site such as concomitant carpal tunnel syndrome or trigger fingers will not be used as exclusion criteria.
clinical pathways for effective and appropriate care

Conditions: Stroke

Summary: the purposes of this study are to determine whether clinical pathways: 1)improve the quality of the care provided to patients affected by stroke in terms of clinical outcomes, efficiency continuity of care and patients' satisfaction; 2) facilitate the use of evidence based medicine in clinical practice.

the coordination of care has been proved to be able to improve prognosis in acute stroke patients. prompt identification of symptoms, organised timely and efficient transportation towards appropriate facilities, has become essential part of effective treatment, as well as organized rehabilitation. the importance of organized stroke care in facilitating recovery has been recognized for the last 10 years, but it is still unclear how organized care contributes to improved outcomes. since clinical pathways aim to promote evidence- and guideline-based care, improve the organisation and efficiency of care, and reduce cost, their implementation may be a method for achieving the organizational standards required to grant appropriate care in stroke. even though in the past decade, care pathways have been increasingly implemented as a tool in acute stroke care and stroke rehabilitation the evidence supports partially the use of clinical pathways in stroke because very little prospective controlled data demonstrated their effectiveness through the continuum of the care. our study was designed in order to conduct a rigorous evaluation of clinical pathways for treatment of acute stroke patients in different types of organized stroke care.

Eligibility criteria:
inclusion criteria: * principal diagnosis of ischemic stroke (icd9cm code 434.91) exclusion criteria: * transient cerebral ischemia (icd9cm code 435.9) * intracerebral hemorrhage (icd9cm codes 431.xx)

Keywords: critical pathways stroke randomized controlled trial effectiveness
impact of a financial success education program in women and children

Conditions: Stress

Summary: many americans are living paycheck to paycheck. this may lead to financial stress and an increase in overall stress. people under stress are more likely to smoke, consume alcohol, eat a poor diet, and experience depression or anxiety. experiencing financial stress may also increase the risk for heart disease. the purpose of this research study is to test whether participating in the financial success program improves health outcomes, in both the women participating and their children.


Eligibility criteria:
inclusion criteria: * women 19 years or older enrolled in the financial success program in fall 2011 and winter 2012 and/or a their child(ren) ages 3-18 years attending the daycare with their mother * women must be employed to be enrolled in the financial success program * able and willing to provide informed consent exclusion criteria: * women less than 19 years of age * women working a night time shift (due to variability in diurnal cortisol secretion) * known pregnancy or planned pregnancy (due to variability in blood pressure, glucose, weight, and lipids) * women are excluded from the financial success program if they are living in a domestic violence situation or abusing alcohol or illicit drugs

Keywords: low socioeconomic status stress women children cortisol
intra-articular polyacrylamide hydrogel in the treatment of knee osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: 1-year follow-up of a randomized controlled trial with open-label extension to assess the long-term efficacy and safety of intra-articular hbisa endoprosthesis of synovial fluid noltrex™ in knee osteoarthritis.

hbisa (polyacrylamide hydrogel) endoprosthesis of synovial fluid noltrex™ is intended for the symptomatic treatment of adult patients with osteoarthritis (oa) reducing pain and improving mobility. the aim of this 1-year follow-up was to evaluate the long-term safety and efficacy of ia polyacrylamide hydrogel with silver ions in patients with kellgren-lawrence grade 3 and 4 knee osteoarthritis who had received one or two treatment courses in the ia/paag-si/oa/2019 and ia/paag-si/oa/2020 studies. follow-up data were collected in telephone interviewing (using questionnaire) in april-july 2022, 12 months after the completion of ole (ia/paag-si/oa/2020).

Eligibility criteria:
inclusion criteria: the study included patients with kl grade 2-3 knee osteoarthritis who had completed study ia/paag-si/oa/2019 and ia/paag-si/oa/2020. exclusion criteria: declining participation in the survey lost to follow-up

Keywords: ia paag hbisa hydrous biopolymer with silver ions "argiform"
behavioral intervention program and vaginal cones on sui

Conditions: Stress Urinary Incontinence

Summary: this study is a single blind randomized clinical trial to compare the efficacy of a behavioral intervention program versus vaginal cones on stress urinary incontinence (sui).

detailed description: in this single-blind randomized clinical trial, 60 women aged 25-65 yrs with stress urinary incontinence were randomly divided in two groups by blocked randomization method; behavioral intervention program (n=30) and insertion vaginal device,vaginal cones (n=30). women in behavioral intervention group were instructed for pelvic floor exercise and bladder control strategies. other group was allocated to use vaginal cones. they were treated for 12 weeks and followed up every 2 weeks. the subjective changes in severity of sui were measured using a detection sui severity questionnaire and leakage index and 3-day urinary dairy. the objective changes were measured by pad test. these two groups were then compared according to the scores of special questionnaires for quality of life, strength of pelvic floor muscles, capability to participate in social activities, severity of urinary incontinence, and the number of involuntary urine passage, taken before, and after 1 and 3 months after finishing interventions. data analysis will be done through descriptive and perceptive statistical methods by using spss.

Eligibility criteria:
inclusion criteria: * symptoms of sui , at least three episodes of stress incontinence per week * age 25-65 * body mass index (bmi) ≤ 30 kg/m2 * physical health exclusion criteria: * chronic degenerative diseases affected on muscular and nerve tissues * vulvovaginitis, atrophic vaginitis, * pregnancy * active or recurrent urinary tract infections * advanced genital prolepses * patients with cardiac pacemakers

Keywords: behavioral intervention program vaginal cones stress urinary incontinence treatment women
study of a therapy without drugs, supplementary to an usual treatment for the pains caused by removing the redon's drain from a 7 to 17 years old child in pediatric surgery.

Conditions: Surgical Operation With the Settle of a Redon's Drain

Summary: the 3rd governmental plan of fighting against the pain favored the development and the evaluation of the efficiency of the non pharmacological methods. its results always showes a lack of knowledge of these methods and the utility to pursue the researches. in the department of pediatric surgery of the university hospital of limoges, the relaxing-touch is one of these methods which is more and more used. the healthcare staff noticed the beneficial effects of such an empirical method in terms of comfort and quality of life for the children. in 2011, a pilot study led in this department showed that, in spite of the usual treatment, the removal of the redon's drain remains painful for 25 % of the children (score on the pain scale \> or = 4). this result convinced the medical team to write a protocol of research from the following hypothesis: the implementation of a protocol of the redon's drain removal associated to the relaxing touch and usual treatment could lead to a decrease of the acute pain for a 7 to 17 years old child.


Eligibility criteria:
inclusion criteria: * children \> or = 7 and \< 18 years old * hospitalization for surgery having required the settle of a redon's drain during surgery. * the presence of at least one of the legal representatives with the child during the care. * the consent of at least one of the legal representatives and agreement of the child for the relaxing-touch method. * the affiliation of one of the legal guardian to the social security. exclusion criteria: * children with an intellectual deficiency preventing the use of the scale eva from the pain. * children having already had one or several removal of the redon's drain: the negative memory of the pain for a similar act could falsify the score of pain * children refusing the usual care of the pain in the department by the meopa.
proton pump inhibitor plus propranolol versus proton pump inhibitor alone on peptic ulcer healing in patients with liver cirrhosis

Conditions: Liver Cirrhosis; Peptic Ulcer

Summary: proton pump inhibitor plus propranolol versus proton pump inhibitor alone on peptic ulcer healing in patients with liver cirrhosis: a randomized trail

portal hypertension is responsible for the development of portosystemic collaterals. the hemodynamic alternations may result in mucosal and vascular changes along gastrointestinal (gi) tract as well. according to several epidemiological studies, cirrhotic patients are at a higher risk of developing peptic ulcers, delayed healing, and a higher frequency of ulcer recurrence. the death rate from peptic ulcer disease in cirrhotic patients has been reported to be five times higher than that of the general population. the exact mechanism remains incompletely understood, but may be related to impaired mucosal defense mechanisms. aggressive factors such as helicobacter pylori and gastric acid may not be the predominant etiology in such circumstances. sarfeh et al. found gastric mucosa of portal hypertensive rats, compared with that of controls, has distinctive functional and histologic abnormalities that can explain its increased susceptibility to erosive injury. auroux et al. found gastroduodenal ulcer was independently associated only with the severity of the hypertensive gastropathy in cirrhotics. chen et al. found portal hypertension with a hepatic venous pressure gradient \> 12 mmhg may be an important factor contributing to the increased prevalence of gastric ulcer observed in patients with liver cirrhosis. thereby, we presumed that clinically significant portal hypertension may play a role in development of peptic ulcer in cirrhotic patients. lebrec et al. elucidated non-selective beta-blocker (nsbb) could significantly decrease portal pressure and lower the risk of gi bleeding in patients with cirrhosis. kitano et al. found portal hypotensive treatment with nsbb, reduces ethanol-induced gastric mucosal damage in portal hypertensive rats and improves endoscopic signs of portal hypertensive gastropathy in cirrhosis patients. we designed a 2-year randomized trial to evaluate the effectiveness of proton pump inhibitor with or without propranolol on ulcer healing and the incidence of ulcer bleeding in patients with cirrhosis and peptic ulcers.

Eligibility criteria:
inclusion criteria: * between 20 and 85 years old * liver cirrhosis associated with esophageal varices or gastric varices * gastric ulcer or duodenal ulcer ,size bigger or egual than 0.5 cm exclusion criteria: * acute bleeding * steroid or nsaid user * pregnancy, or the patients with other terminal illness (such as other terminal cancers, heart failure, renal failure...) * propranolol contraindications (such as atrioventricular block, heart failure, chronic obstructive pulmonary disease, asthma, poorly controlled diabetes, severe peripheral arterial disease...)

Keywords: portal hypertension peptic ulcer non-selective beta-blocker proton pump inhibitor
study of the nutritional, metabolic, and body composition profile in children and adolescents with epidermolysis bullosa

Conditions: Epidermolysis Bullosa

Summary: objectives: i. characterize the nutritional and metabolic profile of children and adolescents with epidermolysis bullosa. ii. determine patterns of body composition in these patients. iii. determine the energy requirements of these patients by measuring resting energy expenditure. iv. assess protein nutrition by measuring lean body mass.

protocol outline: data collected from a 5-day food diary are analyzed for protein, nutrient, and calorie intake. nutritional, metabolic, and body composition are evaluated by indirect calorimetry, total body electrical conductivity, total body potassium, and lean body mass.

Eligibility criteria:
protocol entry criteria: * epidermolysis bullosa * patient age: 2 months to 18 years

Keywords: dermatologic disorders epidermolysis bullosa genetic diseases and dysmorphic syndromes rare disease
the effect of osteopathic manual therapy on vascular supply

Conditions: Knee Osteoarthritis

Summary: the purpose of this study is to determine if the use of osteopathic manual therapy can influence the vascular supply to the knee, knee range of motion, balance and knee pain, in a group of subjects with knee osteoarthritis. it is also the objective of this study to determine if there is a difference between the osteopathic evaluation and the combination of an osteopathic evaluation and treatment.


Eligibility criteria:
inclusion criteria: * radiographic-confirmed knee osteoarthritis exclusion criteria: * subjects who are unable to ambulate independently (without an aid) and safely the distance of a city block * subjects who have an uncontrolled medical condition (e.g. heart (angina) or respiratory condition (asthma)) * subjects who have a neurological condition (e.g. parkinson's, multiple sclerosis) * subjects who have both knees affected by osteoarthritis and have had previous surgery to both knees * subjects who have knee oa in only one knee and that knee has had previous knee surgery * subjects who have previous vascular surgery to either leg

Keywords: knee osteoarthritis manual therapy osteopathy
heart rate variability as a predictor of rebound pain following total knee arthroplasty

Conditions: Rebound Pain; Total Knee Arthroplasty; Postoperative Pain, Chronic; Heart Rate Variability

Summary: this study aims to investigate whether heart rate variability (hrv), a marker of autonomic nervous system activity, can predict the occurrence of rebound pain after total knee arthroplasty (tka). rebound pain is defined as a sudden and intense pain episode (nrs ≥7) that typically arises after the resolution of peripheral nerve blocks used for postoperative analgesia. patients undergoing elective unilateral tka under spinal anesthesia with peripheral nerve blocks will be included. hrv will be measured both before and after surgery using a chest-worn heart rate monitor. pain levels, analgesic consumption, sleep quality, and patient satisfaction will also be recorded. the primary goal is to determine whether perioperative hrv values can serve as a predictive biomarker for rebound pain. secondary outcomes include the relationship between hrv and pain intensity, opioid use, sleep quality, and length of hospital stay. the findings may contribute to developing individualized pain management strategies for tka patients.


Eligibility criteria:
inclusion criteria: * age between 18 and 70 years * american society of anesthesiologists (asa) physical status i-iii * scheduled for elective, unilateral total knee arthroplasty under spinal anesthesia * planned use of multimodal analgesia including peripheral nerve blocks * ability to provide written informed consent * ability to understand and complete pain diaries and questionnaires exclusion criteria: * known allergy to local anesthetics * contraindications to regional anesthesia * contraindications to spinal anesthesia * asa physical status iv or higher * pregnancy or breastfeeding * neurological or psychiatric disorders impairing ability to participate or report outcomes * use of anticoagulant therapy or presence of coagulation disorders * infection at the proposed injection site * emergency (non-elective) surgical procedures