Kornimate/medical-research-clean huggingface dataset:
hemocontrol system activated in hemodiafiltration treatments

Conditions: Renal Failure

Summary: the current study aims to assess the hemocontrol prescription in on-line hemodiafiltration treatment.

hemodiafiltration (hdf) is a dialysis technique that allows the removal of high molecular weight toxic solutes exploiting the convective transport through the dialyzer membrane: at the same time, the hdf has a positive impact on the systemic hemodynamic, ameliorating in this way the tolerance of the treatment. unfortunately, also the hdf therapy can be not well tolerated, introducing in the patients serious hypovolemia during the removal of the body water accumulated in the interdialytic period. the hemocontrol system, automatically controlling the relative blood volume change of the patient, avoids the onset of the hypovolemia. today the hemocontrol system can be used only during conventional hemodialysis treatments; the objective of this study is to combine the advantages of the intradialytic hemodynamic stabilization achievable by means of hemocontrol with the inherent advantages, both of depurative and cardiovascular kind, typical of the hemodiafiltration technique.

Eligibility criteria:
inclusion criteria: * a subject must meet all of the following inclusion criteria in order to participate in this study: * esrd in chronic dialysis treatments for at least 3 months * age ≥ 18 years * body weight ≥ 40 kg * blood flow rate ≥ 250 ml/min with a recirculation of the vascular access \< 5% * use of not fractioned heparin in continuous infusion as anticoagulant * stable anticoagulation dosage over the last 6 treatments * stable dialysis prescription (qb, qd, treatment time) over the last 6 treatments * informed consent for participating to the study * stable haemoglobin concentration at beginning of the treatment lower than or equal to 14 g/dl. exclusion criteria: * a subject shall not participate in the study if he/she meets any of the following criteria: * hiv positivity * active hepatitis a, b or c * pregnancy * participating in other clinical investigations during the course of this study * failed to release consent * known coagulation disorders (clotting problems) * known bleeding risk * clinical or laboratory diagnosis of acute infection * recent (last 4 weeks) surgical intervention * therapy prescribed is only hd, hf or isolated uf mode * active phase cancer, * active phase immune disease. * serious hemostasis disorders.

Keywords: hemodiafiltration hemodialysis sodium artis renal failure
effect of teas on rocuronium injection pain

Conditions: Injection Pain

Summary: pain from the injection of rocuronium is a common side effect during anesthetic practice, occurring in 50%-80% of patients. several methods have been used to reduce this pain. this prospective, randomized study was designed to determine the efficacy of transcutaneous electrical acupuncture point stimulation in reducing the rocuronium injection pain.


Eligibility criteria:
inclusion criteria: * 18-65 year aged * asa i-iii * who was to undergo various elective operations. exclusion criteria: * cardiovascular surgery * patients with pacemakers * patients requiring rapid sequential induction
a study to evaluate the effectiveness and safety of multiple applications of imiquimod 5% cream for the treatment of actinic keratoses in organ transplant recipients

Conditions: Actinic Keratosis

Summary: the purpose of the study is to compare effectiveness and safety of multiple applications of imiquimod 5% cream and vehicle cream in graft recipients suffering from actinic keratosis.


Eligibility criteria:
inclusion criteria: * have a total of 4-10 actinic keratosis (ak) lesions located on either face or scalp * if female and of childbearing potential, have a negative urine pregnancy test at treatment initiation, and willing to use a medically acceptable method of contraception during the treatment period * renal, liver or heart transplant recipients exclusion criteria: * graft rejection with loss of the graft in the medical history * unstable status of organ transplant disease during the last 12 months * known to be pregnant or lactating

Keywords: aldara actinic keratosis graft recipients
monitoring of non-surgical treatment of peri-implantitis

Conditions: Peri-implant Mucositis; Peri-Implantitis

Summary: this study aimed to investigate the response to non-surgical treatment of peri-implantitis diseases during the maintenance phase. the patients underwent non-surgical implant maintenance treatment, and the success of the treatment was measured again after 30 days using the same criteria and methods.

for 40 patients, the ammp-8 test was performed on the buccal gingival pocket of the implant teeth, gingival bleeding (bop), implant pocket depth (ppd), and a periapical x-ray to measure radiologic bone level (rbl) were taken.

Eligibility criteria:
inclusion criteria: * implant patients arriving for a maintenance visit at a dental clinic * a diagnosis of peri-implant healthy, peri-implant mucositis, or peri-implantitis by a dentist * a written informed consent. exclusion criteria * smoking * age under 25 * antibiotic treatment within six months * the maintenance treatment had been completed within 6 months.

Keywords: peri-implant treatment ammp-8 non-surgical treatment
tolerance of increased infusion rates of intravenous fat emulsions in very low birth weight infants

Conditions: Low Birth Weight

Summary: this study was completed in october 2006. no further participates are being recruited.


Eligibility criteria:
inclusion criteria: * all infants who are appropriate for gestational age at birth and who have a birthweight between 750-1500 grams will be enrolled in this study.

Keywords: this study was completed in october 2006
a study of safety and efficacy of pimavanserin (acp-103) in patients with parkinson's disease psychosis

Conditions: Parkinson's Disease Psychosis

Summary: this study will evaluate the safety and efficacy of two dose levels of pimavanserin (acp-103) compared to placebo in patients with parkinson's disease psychosis.


Eligibility criteria:
inclusion criteria: * a clinical diagnosis of parkinson's disease with a minimum duration of 1 year * presence of visual and/or auditory hallucinations, and/or delusions, occurring during the four weeks prior to study screening * psychotic symptoms must have developed after parkinson's disease diagnosis was established * subject must be on stable dose of anti-parkinson's medication for 1 month prior to study day 1 (baseline) and during the trial * subject that has received stereotaxic surgery for subthalamic nucleus deep brain stimulation must be at least 6 months post surgery and the stimulator settings must have been stable for at least 1 month prior to study day 1 (baseline) and must remain stable during the trial * the subject is willing and able to provide consent * caregiver is willing and able to accompany the subject to all visits exclusion criteria: * subject has a history of significant psychotic disorders prior to or concomitantly with the diagnosis of parkinson's disease including, but not limited to, schizophrenia or bipolar disorder * subject has received previous ablative stereotaxic surgery (i.e., pallidotomy and thalamotomy) to treat parkinson's disease * subject has current evidence of a serious and or unstable cardiovascular, respiratory, gastrointestinal, renal, hematologic or other medical disorder * subject has had a myocardial infarction in last six months * subject has any surgery planned during the screening, treatment or follow-up periods patients will be evaluated at screening to ensure that all criteria for study participation are met. these evaluations will include specific measures of psychosis severity, delirium, dementia, cardiovascular condition, and pregnancy status. patients may be excluded from the study based on these assessments (and specifically if it is determined that their baseline health and psychiatric condition do not meet all protocol-specified entry criteria).
safety, tolerability, pharmacokinetics and pharmacodynamics study of single-dose injection of shr-2004 in healthy subjects

Conditions: Prevention of Arterial and Venous Thrombosis

Summary: the primary objective of this study is to assess the safety and tolerability of shr-2004 injection in healthy subjects. in addition, this study will provide information on pharmacokinetics and pharmacodynamics of shr-2004 injection in healthy subjects.


Eligibility criteria:
inclusion criteria: 1. males or females, aged 18-55; 2. body mass index (bmi) between 19 kg/m2 to 28 kg/m2, and a total body weight: male ≥50.0 kg and \<90.0 kg; female ≥45.0 kg and \<90.0 kg. exclusion criteria: 1. previous medical history of coagulation or bleeding disorders; 2. known risks of bleeding or thrombosis, such as recurrent gingival bleeding, spontaneous bleeding, haemorrhoids, gastrointestinal ulcers, or other high-risk bleeding diseases.
organ procurement : usefulness of a guide for meeting with the next of kin

Conditions: Organ Donation

Summary: a dedicated guide for physicians and organ procurement nurses meeting with the next of kin could be associated with a reduction in organ donation refusal rate, and in anxiety of professionals involved in such meetings

the main obstacle for organ procurement in brain dead patients in france is organ donation refusal by the next of kin. when refusal is reflecting the patient's position, ending the organ donation procedure respects the bioethic french laws. nevertheless, the actual position of the deceased patient often remains unknown. in these cases, organ donation refusal does not necessarily respect the deceased wishes. many factors have been associated to next of kin organ donation refusal in such situations. among those factors, some concerning the meeting with the next of kin have been isolated. french data on this subject are lacking. a dedicated guide for the conduct of meetings with the next of kin has been elaborated by a working group of our network. its diffusion will take place last quarter of 2016. the purpose of our study is to evaluate its usefulness through an observational multicenter before-after study, concerning every situation of brain dead patient where the next of kin are met by the medical staff. the refusal rate will be assessed over the first period (before the diffusion of the guide), from july 2012 to june 2014, and compared to that assessed over the second period (after the diffusion of the guide) from january 2017 to december 2018, using the national database of biomedicine agency. a comparison of this change in refusal rate will be made between centers of our network and the remaining centers in france nationwide. anxiety of professionals will be assessed prospectively after each meeting conducted in one of our network centers, over 2 periods, before (from july to october 2016) and after (starting in january 2017) the diffusion of the dedicated guide for the conduct of the meeting with the next of kin. compliance to the guide by the physicians and organ procurement nurses will be assessed after its diffusion in the centers of our network.

Eligibility criteria:
inclusion criteria: * situation of confirmed brain dead patient, or dead patient with pending confirmation of brain death exclusion criteria: * situations where the next of kins are met before brain death

Keywords: organ procurement brain death organ donation next of kins
open-label, uncontrolled postmarketing study of cell-derived a/h1n1 influenza ha vaccine in japanese elderly subjects

Conditions: Swine-Origin Influenza A H1N1 Virus

Summary: this is to evaluate immunogenicity based on emea/chmp criteria, and safety \& tolerability of cell-derived a/h1n1 influenza ha vaccine in healthy japanese elderly subjects.

this is an open-label, uncontrolled post-marketing study of the cell-derived a/h1n1 influenza ha vaccine. subjects received 3.75μg of cell-derived h1n1sw vaccine formulated in half (i.e., half the content of the european-licensed adjuvanted seasonal influenza vaccine) mf59 adjuvant (3.75_halfmf59). all vaccination were administered im in the deltoid muscle, preferably of the non-dominant arm at the first vaccination and of the opposite arm to the first vaccination, as a rule, at the second vaccination. blood samples were collected at baseline (day1), 3 weeks after the first vaccination (day 22) and three weeks after the second vaccination (day 43). sera were tested by hemagglutination inhibition (hi) assay. local and systemic reactions were collected for the first week following each injection using diary card (i.e. day 1 to day 7 and day 22 to day 28). all aes, saes, and aes that led to withdrawal from the study and related prescription medications were collected for the entire study period.

Eligibility criteria:
inclusion criteria: * healthy japanese aged over 60 years exclusion criteria: * any serious chronic or progressive disease according to judgment of the investigator (including, but not limited to neoplasm, insulin dependent diabetes, cardiac, renal, hepatic or respiratory disease) * history of any anaphylaxis, serious vaccine reactions, or hypersensitivity to influenza viral proteins, to any excipients * administration of swine influenza (a/h1n1) vaccine prior to day 1 or documented confirmed or suspected swine influenza disease * history of progressive or sever neurological disorders * known or suspected impairment/alteration of immune function

Keywords: influenza a h1n1 subtype children/adolescent vaccine adjuvant cell culture
digital subtraction radiography evaluation of smart restoration with partial caries removal in primary teeth

Conditions: Dental Caries Extending Into Dentine

Summary: the objective of this study was to analyze the radiographic density of digital subtraction radiographs after smart restoration with partial caries removal in primary molars at 6 and 12 months.

in management of deep caries in primary teeth, the partial caries removal approach favored the arrest of dentin carious lesions, reduced cariogenic micro-organisms and the risk of pulp exposure. the carious tissue at the lateral walls of the cavity at the enamel dentin junction (edj) was removed by a spoon excavator without carious tissue removal at the pulpal site. after caries removal, restoration using glass ionomer cement (gic)(gc fuji ix™gp extra) was completed. such an approach is called smart restoration. the serial radiographs of each restoration consisted of three radiographs; immediately after restoration, at the 6-month follow-up and at the 12-month follow-ups. digital subtraction radiography(dsr) was used to evaluate dentin remineralization following partial caries removal. image-pro plus software was used to evaluate dsr. for evaluating the changes in dsr, areas with increase density show higher radiopacity, whereas areas with decreased density show higher radiolucency. the 6-month and 12-month follow-up radiographs were subtracted from the baseline radiograph.

Eligibility criteria:
inclusion criteria: * presence of teeth with dentinal caries limited to the occlusal and proximal surfaces without clinical signs and symptoms of irreversible pulpitis (spontaneous pain, sinus opening, or abnormal tooth mobility * the radiographic examination showing dental caries involving not less than half of the dentin without any pathologic findings (external root resorption, internal root resorption, abnormality of root resorption, or radiolucency area at furcation /periapical regions). exclusion criteria: * teeth with caries exposure to pulp

Keywords: dentin remineralization caries regression
comparison of the effects of telerehabilitation and face-to-face spinal stabilization trainings on gait biomechanics, balance and joint position sense in transtibial amputees: a randomized controlled, single blind study

Conditions: Amputation

Summary: after transtibial amputations, biomechanical changes in the trunk, pelvis, and lumbar region cause asymmetrical strength and core muscle activation on the amputated side, which negatively affects the gait biomechanics of individuals. however, routine treatment programs do not use treatment approaches based on the core region. this study will focus on the effects of telerehabilitation and face-to-face spinal stabilization exercise training on gait, balance, joint position sense, core muscle function, and perceived mobility in transtibial amputees, after treatment, and after long-term follow-up.


Eligibility criteria:
inclusion criteria: * individuals who use total contact sockets * have been using prostheses for at least 1 year, * can walk independently without a walking aid * functionally at least k2 exclusion criteria: * bilateral amputation * upper extremity amputation * neurological problems * other orthopedic problems
a safety and efficacy study of onabotulinumtoxina in forehead and glabellar facial rhytides

Conditions: Forehead Rhytides; Glabellar Rhytides

Summary: this is a safety and efficacy study of onabotulinumtoxina in subjects with forehead and glabellar facial rhytides (frown lines).


Eligibility criteria:
inclusion criteria: * moderate to severe forehead and glabellar lines * willing to have facial photos taken exclusion criteria: * prior exposure to botulinum toxin of any serotype for any indication * anticipated need for treatment with botulinum toxin of any serotype for any indication during the study, other than study treatment * diagnosis of myasthenia gravis, eaton-lambert syndrome, or amyotrophic lateral sclerosis * any facial resurfacing laser or light treatment, microdermabrasion, or superficial peels in the past 3 months * any medium depth or deep depth facial chemical peels; facial skin resurfacing; or permanent facial make-up in the past 6 months * any nonpermanent soft tissue fillers, or treatment with oral retinoids in the past year * prior face lift, thread lift, eyebrow lift, or related procedures (eg, eyelid and/or eyebrow surgery) * prior facial treatment with permanent soft tissue fillers, synthetic implants (eg, gore-tex®), and/or fat transplantation
quality of life in juvenile patients with uveitis

Conditions: Uveitis

Summary: data about psychodynamics in uveitis patients are scare. a negative impact of disease is described not only in adult patients with active, but also with quiescent disease. during adolescence even less is known about psychodynamics although this is an especially sensible and challenging stage of life. given the assumption that juvenile patients with quiescent disease still could suffer from emotional distress, this would require special attention. in this study the investigators evaluate the impact of juvenile uveitis on hrqol and attempted to identify clinical and demographic factors contributing to an impaired health status. the investigators limit the study to patients with quiescent uveitis and good visual function in at least one eye to exclude additional negative stressors. as there are no validated uveitis-specific psychometric questionnaires evaluating qol available yet, the investigators use age-appropriate generic instruments. this should allow obtaining an overview about the adolescents' general health-related quality of life (hrqol) and whether psychological interventions should be offered to this sensitive patient group.


Eligibility criteria:
inclusion criteria: * patients with uveitis * aged 11-18 years * willing to participate * parent or legal guardian agrees with participation of adolescent exclusion criteria: * not willing to participate * parent or legal guardian does not agree with participation of adolescent

Keywords: childhood uveitis health-related quality of life gender
adjunctive role of prf after free gingival graft harvesting - case series

Conditions: Platelets Rich Fibrin, Palatal Donor Tissue

Summary: free gingival grafts are important to increase zone of attached gingiva and root coverage. this case series reveals role of platelet-rich fibrin (prf) as adjunctive therapy in palatal wound healing. the superior healing observed at the prf membrane sites supports its use in accelerating soft-tissue healing. prf membrane as a palatal bandage is an efficacious approach to protect the raw wound area of a palatal donor site to reduce healing time and patient discomfort.

introduction: free gingival grafts are one of the common treatment modalities used to increase the zone of keratinized tissue (kt) around implants or prior to ridge augmentation and root coverage. the palatal donor sites had many complications as pain, discomfort and healing by secondary intention. platelets rich fibrin (prf) is a second generation of platelets concentrate full of growth factors fasten the healing and decrease the pain. materials and methods: ten patients requiring augmentation of kt participated in this case series. the palatal donor sites of 7 of these patients were covered with prf membranes with a new suturing technique without palatal stent, the other 3 had palatal stent. palatal tissue will examined clinically after 3, 7, 10 and 14 days. considerably very fast healing with 0 pain score was observed during one week in the group with prf.

Eligibility criteria:
inclusion criteria: * systemic free, good oral hygiene and insufficient attached gingiva prior to ridge augmentation exclusion criteria: * high arched palate, medically compromised
effects of exercise poles on older adults during exercise walking

Conditions: Movement Disorders; Aging

Summary: this study uses a patented type of exercise poles, developed to assist runners rehabilitating from lower body injuries. these poles may offer older adults improved stability, reduced fear of falling, and lessened lower body pain when exercise walking.

phase 1 (being concluded as of feb 2002) used 18 older adults to investigate prototype versions of the running poles. preliminary results, after 3 months of testing, indicate the poles are safe and effective. phase 2 will use improved versions of the poles, which are currently in development, with a group of around 125-150 subjects over a longer length of time (12 months). changes in walking gait quality, balance, strength, body composition, exercise adherence, and subjective perceptions of wellness will be assessed before, during, and after the 12 month exercise session.

Eligibility criteria:
inclusion criteria: * age 65-80 * normal gait exclusion criteria: * inability to walk continuously for 5 minutes * contraindication from a personal physician * height over 6'2" or weight over 200 lbs (due to limitations of existing pole design) * mild to severe cognitive impairment

Keywords: fall-prevention balance musculoskeletal systems protective devices gait equilibrium accidental falls frail elderly