Kornimate/medical-research-clean huggingface dataset:
the rewire study (mindfulness mobile app to reduce adolescent substance use)

Conditions: Adolescent Substance Use

Summary: the current proposal is aimed at developing a substance use cessation app (rewire) for high risk adolescents who are involved in the juvenile justice system. the rewire app will be based on the primary substance use cessation components tested in our previous work with juvenile justice-involved adolescents and on intervention components shown to be central to smoking cessation.

the rewire study will recruit 60 youth (30 boys and 30 girls) who have had contact with the department of youth services in the last year. consent will be obtained from parents or guardians for the youths' participation. the participating teens will come to oregon research institute for a baseline assessment. during this visit, the teens will complete an assent form and spend 20-30 minutes completing an online survey with an assessor; topics covered in the survey include emotion regulation and drug and alcohol use. teens will have the app loaded onto their phones and be provided with instructions for its use during this visit. participants are asked to use the app over the next 2 weeks, completing 4 modules and spending 5-10 minutes each day answering questions about recent emotions and substance use. teens will be contacted via email for follow up assessments at 8 weeks post-baseline. these emails will contain links to the follow-up surveys which also ask about emotion regulation and drug and alcohol use; surveys should take 20-30 minutes to complete.

Eligibility criteria:
inclusion criteria: * ages 13 to 18 * involved with juvenile justice system * documented substance use * english-speaking * living in the community exclusion criteria: * non english-speaking * living in treatment or detention facility
gait disorders in patients with cognitive decline

Conditions: Gait Disorders, Neurologic

Summary: the prevalence of neurodegenerative diseases will increase over the next decades driven by ageing population. it seems important to develop reliable, replicable and accessible diagnostic tools. this is a prospective study whose objective is to study the spatio-temporal parameters of gait in patients with alzheimer's and lewy body diseases. 64 patients were included in this study. a comparison of the two pathologies was conducted, followed by an analysis based on four groups (mild, severe alzheimer's disease, mild, severe lewy body disease) and a study of the severity of the diseases. to study these parameters, we used the gaitrite treadmill. the analysis of spatio-temporal parameters of walking in alzheimer's disease and lewy body disease enables to identify discriminating variables between the two pathologies. the probability of suffering from an alzheimer's disease decreases with the pace increase but increases with variations in length of the step, and with the rotation of the foot. while the probability of suffering from lewy body disease increases with the pace, variations in the step duration, and the duration of double support. these results are interesting but do not allow to establish a diagnostic score for these two diseases. the monitoring of the variations of these parameters at individual level would probably be more relevant and would enable to detect dual pathologies.


Eligibility criteria:
inclusion criteria: * patient over 50 * hospitalized patient in day hospital * patient with an etiological diagnosis of his cognitive disorder * patient having a neuropsychological assessment * patient able to walk without technical help * patient having agreed to participate in the study exclusion criteria: - refusal to participate in the study

Keywords: gait disorders spatio-temporal parameters of walking alzheimer's disease lewy body disease
sustaining training effects through physical activity

Conditions: Pulmonary Disease, Chronic Obstructive

Summary: this randomized control trial will investigate whether the implementation of a telecoaching program, initiated during pulmonary rehabilitation, is able to increase and maintain physical activity and general benefits until six months after rehabilitation discharge. after three months of pulmonary rehabilitation (3 times a week), patients with copd will be randomized to either an intervention group which receives an additional telecoaching program on top of the pulmonary rehabilitation, or to the usual care group, which only receives rehabilitation program. apart from the added telecoaching program to the intervention group, the rehabilitation program will be identical and last for another three months (2 times a week). after discharge, both groups will be followed up for six months.


Eligibility criteria:
inclusion criteria: * patients with a primary diagnosis of copd according to internationally accepted guidelines * patients that completed three months of the outpatient pulmonary rehabilitation program of gasthuisberg university hospital (leuven, belgium) * current or previous smoking exposure of at least 10 pack years * ability to manage electronic devices (smartphone, step counter) exclusion criteria: * other predominant respiratory diseases than copd (asthma, pulmonary hypertension) * orthopedic, neurological and muscular co morbidities that could interfere with normal biomechanical movement patterns and the ability to increase physical activity levels * patients on the waiting list for lung transplantation

Keywords: physical activity pulmonary rehabilitation copd
multicomponent fibrowalk therapy plus unified protocol for emotional regulation in individuals with fibromyalgia

Conditions: Fibromyalgia (FM)

Summary: fibromyalgia is a chronic condition characterized by widespread pain, fatigue, sleep disturbances, and cognitive dysfunction. although the fibrowalk multicomponent program improves physical functionality and pain, its impact on emotional regulation remains limited. this study aims to integrate the unified protocol (up), a cognitive-behavioral therapy (cbt) approach, to enhance emotional and physical distress tolerance in fibromyalgia patients and explore participants' satisfaction, difficulties, and barriers to treatment. this study investigates the efficacy of integrating the unified protocol (up), a transdiagnostic intervention based on cbt, with the multicomponent fibrowalk therapy for individuals with fibromyalgia. the trial seeks to enhance emotional regulation, reduce anxiety and depression, and improve quality of life. additionally, it will gather qualitative feedback from participants to identify challenges, barriers, and potential improvements to the therapeutic intervention.


Eligibility criteria:
inclusion criteria: * adults diagnosed with fibromyalgia, according to the 2011 american college of rheumatology (acr) modified criteria. * aged 18 or older. exclusion criteria: * individuals with psychotic disorders, substance abuse, or severe cognitive impairment (based on medical evaluation).
mechanism exploration of anti-her-2 small-molecule tyrosine kinase inhibitor-related diarrhea and establishment of prevention and treatment model(measure)

Conditions: Breast Cancer

Summary: small-molecule tyrosine kinase inhibitors (tki) that target her2 are routinely used to treat patients with her2 (+) breast cancer. the main adverse reactions included diarrhea, nausea, and rash, among which diarrhea had the highest incidence. it can reduce the quality of life and medication compliance of patients, and further affect the efficacy of tki anti-tumor therapy. therefore, the investigators conducted this study to establish a risk assessment model before tki treatment, in order to screen out the high-risk population and influencing factors of tki-associated diarrhea, and planned to carry out corresponding animal experiments to verify the relationship between various mechanisms and the main mechanism in tki-associated diarrhea and to explore the corresponding treatment methods.


Eligibility criteria:
inclusion criteria: * plan to take pyrrolidine or naratinib for ≥ 28 days; * her2 positive female patients with breast cancer aged ≥ 18 years and ≤ 65 years; * patients with the following treatment schemes: 1. pirotinib/naratinib monotherapy 2. pirotinib/naratinib combined endocrine therapy; 4. the ecog score is 0-1; * life expectancy ≥ 6 months; * patients who followed diet intervention after enrollment; * volunteer to join the study, sign the informed consent form, have good compliance and are willing to cooperate with follow-up. exclusion criteria: * people who may be allergic to pyrrolidine, naratinib or excipients; * there are many factors that affect the absorption of oral drugs, such as inability to swallow, nausea and vomiting; * patients with biliary obstruction; * participate in other clinical trials related to diarrhea; * pregnant and lactating women, women with fertility and positive baseline pregnancy test, or women of childbearing age who are unwilling to take effective contraceptive measures during the whole trial period; * according to the judgment of the investigator, there are concomitant diseases (including but not limited to severe hypertension and severe diabetes beyond drug control) that seriously endanger the patient's safety or affect the patient's completion of the study; * have taken other drugs that may cause diarrhea adverse reactions within 3 weeks before enrollment; * there are drugs with high probability of causing diarrhea adverse reactions in patients' combined medication; * any other situation in which the researcher believes that the patient is not suitable to participate in this study.
multi-center pre-bariatric weight loss study

Conditions: Obesity

Summary: the purpose of the study is to evaluate the safety and efficacy of the gi sleeve in patients who require weight loss prior to their bariatric surgery.

this is a randomized, patient blinded, prospective study.patients will receive either a device or a sham procedure. patients will be evaluated for the study and randomized to a treatment group if they qualify for the study. throughout the study their weights will be obtained and various laboratory tests collected. a comparison of weight loss between the two groups will be assessed as the primary outcome measure.

Eligibility criteria:
inclusion criteria: * bmi \> 35 with a significant comorbid condition or bmi 40-60 * candidate for bariatric surgery exclusion criteria: * no pathologies of the gi tract * no anti-coagulant or non-steroidal anti-inflammatory medications

Keywords: weight reduction
dexamethasone intravitreal implant in retinal vein occlusion

Conditions: Macular Edema, Cystoid

Summary: purpose: to evaluate retinal functional improvement by means of visual acuity and retinal sensibility examination after intravitreal dexamethasone implant in patients affected by cystoid macular edema secondary to retinal vein occlusion.

cystoid macular edema represents the most important cause of visual impairment after retinal vein occlusion. the etiological factors of this complication are under investigation, from inflammatory cytokines to the breakdown of vascular barrier with increased permeability and diffusion of angiogenic factors. clinical research developed different drugs and therapeutic strategies to treat and control macular edema, to evaluate the correct timetable and to reach long-term clinical significative results. at now, different experiences have been published with available drugs, from steroids to anti vascular endothelial growth factor. a debate still remains about the correct approach, the correct combination of drugs (if necessary) and the correct evaluation of drug effectiveness. in our study, we will evaluate extensive functional recovery and its relation to macular thickness after steroid injection. considering that visual acuity reflects only foveal function, it may not be sufficient to evaluate the overall function on the macular area. we introduce microperimetry study as a valuable and reproducible tool to create a functional mapping of the entire macula.

Eligibility criteria:
inclusion criteria were: age older than 18 years; cme secondary to retinal vein occlusion, disease duration inferior to 12 weeks; best-corrected visual acuity (bcva) between 20/200 and 20/25 (snellen equivalent) in the study eye at baseline examination, central retinal thickness (crt) superior to 300 mm, as measured by optical coherence tomography at baseline examination. the exclusion criteria were any ocular surgery in the study eye in the past 6 months; diabetes mellitus with signs of diabetic retinopathy; previous laser photocoagulation; previous intravitreal injection of corticosteroids or anti-vascular endothelial growth factor; a history of ocular inflammation; marked retinal ischemia or retinal hemorrhages (in particular in macular region involving the fovea); any other ocular condition such as anterior ischemic neuropathy, amblyopia or significant media opacities; significant alteration on epiretinal surface such as epiretinal membrane or vitreomacular traction; uncontrolled or advanced glaucoma; any uncontrolled systemic disease.

Keywords: steroid retinal vein occlusion macular edema
leflunomide for idiopathic pulmonary hemosiderosis in children

Conditions: Idiopathic Pulmonary Hemosiderosis; Leflunomide

Summary: the goal of this clinical trial is to compare leflunomide in idiopathic pulmonary hemosiderosis. the main questions it aims to answer are: * the efficacy and safety of leflunomide in idiopathic pulmonary hemosiderosis * the mechanism of leflunomide in treating idiopathic pulmonary hemosiderosis participants will be treated with leflunomide plus stroid. a comparison group: researchers will compare the control group treated with stroid to see if the efficacy of leflunomide would be better than control group.

this study conducted a prospective, open, parallel controlled, single center clinical trial on the combination of leflunomide and stroid therapy for children with iph, and conducted a one-year follow-up. the main indicators (pulmonary hemorrhage/hemoptysis frequency) and secondary indicators (serum iron metabolism level, t lymphocyte subpopulation, lung function, inflammatory cells, and inflammatory factors) were evaluated before and after treatment, exploring the safety and effectiveness of leflunomide in the treatment of iph, it is expected that the combination of leflunomide and conventional treatment can improve the remission rate of clinical symptoms in children with iph, inhibit the progressive deterioration of lung function, and the research results are expected to bring new treatment methods and strategies for this group of patients.

Eligibility criteria:
inclusion criteria: 1. age range from 6 months to 18 years old; 2. diagnose as iph; 3. parents or guardians agree to treatment and sign a written informed consent form. exclusion criteria: 1. individuals who are allergic to any ingredients used in leflunomide tablets; 2. complicated with serious basic diseases (such as systemic malignant diseases, heart failure, liver and kidney failure, immune deficiency, serious infectious diseases, lung transplantation or other patients with immediate surgical indications); 3. patients with other lung diseases; 4. have a history of abnormal coagulation or abnormal coagulation function in the past; 5. clinical trial participants who have previously participated in the treatment of flumiphene; 6. other situations where the researcher deems it inappropriate to participate in the study.

Keywords: idiopathic pulmonary hemosiderosis leflunomide glucocorticoid
risperdal consta and health care utilization in patients with schizophrenia

Conditions: Schizophrenia; Schizoaffective Disorder

Summary: the purpose of this study is to determine if risperdal consta will affect the healthcare utilization costs in chronically ill schizophrenic patients with multiple admissions to the psychiatric hospital compared to the previous utilization costs under standard oral treatment of any atypical antipsychotic. we hypothesize that higher risperdal consta acquisition costs can be offset by reduction in total medical utilization costs, such as hospitalizations, er visits, unscheduled outpatient visits or incarcerations due to worsening of psychotic symptoms.


Eligibility criteria:
inclusion criteria: * primary diagnosis of schizophrenia or schizoaffective disorder * 4 or more admissions to psychiatric hospital in past year, or minimum of 2 hospital admissions and at least 2 incarcerations in the previous year * medicaid recipient * patients requiring concomitant non-antipsychotic psychotropic medication (mood stabilizing, antidepressants, anxiolytics) exclusion criteria: * past or current psychiatric disorder, other than schizophrenia or schizoaffective disorder * drug or alcohol dependence * serious, unstable medical illness or any acute medical condition * pregnant or lactating females * prior risperdal consta treatment * non-english speaking
lateral suspension and sacropexy for pelvic organ prolapse

Conditions: Pelvic Organ Prolapse

Summary: pelvic organ prolapse (pop) is considered one of the commonest gynecologic health problems all over the world. pelvic organ prolapse (pop) is common and can be seen in up to 50% or more of parous women. the annual aggregated rate of associated surgery for pelvic organ prolapse is in the range of 10-30 per 10,000 women. it is estimated that women have an 11-19% life-time risk of undergoing surgery for pop. this rate is projected to increase over the next 2-3 decades. apical pop refers any descent of the cervix or the vaginal cuff scar(as after hysterectomy) below a point which is 2 cm less than the total vaginal length about the plane of the hymen. apical pop is due to defect in apical support with damage to the cardinal and uterosacral ligaments. apical pelvic organ prolapse is a common issue in our country with significant incidence rate due to many predisposing factors including increasing age, higher gravidity and parity (especially the number of vaginal births)

by one estimate, the demand for health care services related to pelvic floor disorders will increase at twice the rate of the population itself . so we need adequate understanding of the best surgical method for treating apical pop which is accepted worldwide and also must be cost effective with least perioperative complications. abdominal sacropexy is considered now the gold standard operation for treatment of apical pelvic organ prolapse. in this technique, the mesh is ﬁxed to the anterior longitudinal ligament at the sacral promontory. it is used either with uterine preservation (sacrohysteropexy) or after hysterectomy (sacrocolpopexy) for treatment of vault prolapse .however , many intraoperative complication can occur including hemorrhage or transfusion or both occurred in 4.4% , intestinal injury or rectal injury in 1.6% (0.4% to 2.5%),and ureteral injury in 1.0% of cases. postoperative complications include paralytic ileus in 3.6%.transient femoral nerve injury and vertebral osteomyelitis . also, despite that sacropexy provide good apical support, but the high prevalence of cystocele and urinary tract symptoms in patients reaches up to 8% . consequently, it is not surprising that the majority of failures following sacrocolpopexy occur in the anterior compartment. lateral suspension with mesh was ﬁrst reported by dubuisson in 1998 for the treatment of pelvic organ prolapse . the lateral suspension avoids both the risk of vascular injury and nerve damage of sacrocolpopexy with success rate up to 88% of cases.

Eligibility criteria:
inclusion criteria: * apical prolapse stage 2-4 according to pop-q system * uterine preservation or after hysterectomy * sexually active or not. exclusion criteria: * pregnancy or up to 6 months postpartum. * current urinary tract infection proved by urine analysis or urine culture. * patient unfit for surgery. * previous suspension operations. * uncontrolled diabetic patients. * urge incontinence.
orientation booklet for low back pain

Conditions: Low Back Pain

Summary: the aim of this study was to evaluate the effect of exercises performed under monitoring of the physiotherapist and self performed at home by reading the booklet of exercise orientation for patients with nonspecific low back pain. a prospective and randomized trial was performed in 44 patients. g1 patients received a physiotherapist orientation, and g2 patients received the booklet of exercise to self perform the exercises. pain intensity by visual analogue scale (vas), and quality of life by sf-36 were measured before. results: pain intensity was lower in g1 than in g2 after 6 and 12 weeks. quality of life was better in g1. the exercises under orientations of the physiotherapist promoted best effect than self performed exercises .

after approval by the ethics committee and signing a consent form, a prospective, randomized trial was performed in 44 patients with chronic nonspecific low back pain (lasting longer than 3 months), pain intensity greater than 3 by visual analogue scale and age \> 18 years. patients with renal and gastrointestinal disease, simultaneously submitted to another type of physical therapy, cognitive impairment, and pregnant women were excluded. all patients received an exercise booklet which consisted of stretching and strengthening of muscles. g1 patients were orientated by the physiotherapist during the performance of exercises once a week, using the booklet, and the patients in g2 (n=22) received the booklet to self perform the exercises without orientation of the physiotherapist. everyone should perform the exercises once a day at home. pain intensity by vas, and quality of life by sf-36 were measured before the start of treatment (t0), after 6 (t6) and 12 (t12) weeks. side effects were recorded. acetaminophen (up to 4 g / day) could be used as necessary. the sample size was provided by sas 8.0, spss 15.0 program. to detect difference in pain intensity of 3 between the groups by vas, with 95% of power (estimated sd= 2.0), when the alpha level is set at 0.05, the sample should be of 16. the program used for statistical analysis was sas 8.0, spss 15.0. the tests used were student's t to compare age of patients, chi-square to compare gender and analgesic complementation, and mann whitney test for pain intensity and quality of life.

Eligibility criteria:
inclusion criteria: * chronic nonspecific low back pain (lasting longer than 3 months), * pain intensity greater than 3 by visual analogue scale and age \> 18 years exclusion criteria: * patients with renal and gastrointestinal disease, * simultaneously submitted to another type of physical therapy, * cognitive impairment, and * pregnant women were excluded

Keywords: low back pain exercise booklet
factors influencing the risk of surgical site infections and wound complications in operatively treated ankle fractures in the elderly

Conditions: Ankle Fractures

Summary: this study is to analyse risk factors for wound complications or surgical site infections and to analyse whether risk factors for wound complications or surgical site infections are also factors for other complications. based on the data from this study it will be investigated whether a risk score can be build up to predict individual risk for a complication after surgery.


Eligibility criteria:
inclusion criteria: * patients ≥ 50 years with ankle fractures surgically treated at the university hospital basel * sufficient follow up at the university hospital basel in order to judge wound healing complications over a 4 weeks period and fracture related infection over a 3 months period exclusion criteria: * existence of a documented dissent. * distal tibia fractures and pilon fractures * followed up at another institution or with no follow up at our institution for any other reason

Keywords: surgical site infections wound complications operatively treated ankle fractures delayed wound healing