Kornimate/medical-research-clean huggingface dataset:
baby swim as an intervention for depressive symptoms and lacking attachment during the postpartum period

Conditions: Depression - Major Depressive Disorder; Attachment; Postpartum

Summary: mental health issues are very common during and after pregnancy, and studies from around the world indicate that 10-15% of all pregnant and postpartum women experience depression. risk factors for developing depression include a history of depression, low levels of social support, and stressful life events. the symptoms are the same as for depression during other periods of life, but often include feelings of inadequacy regarding motherhood, along with associated feelings of shame or guilt. obsessive thoughts directed toward the baby may also be part of the symptomatology. such thoughts are typically experienced as frightening by the mother but, in the vast majority of cases, do not pose any risk to the child. maternal depression can also affect a mother's ability to bond with her baby, and difficulties in forming an attachment can, in turn, increase and perpetuate depressive symptoms. in the long term, insecure attachment between mother and child can lead to behavioral problems in the child, such as aggression and avoidance, anxiety and depression in adolescence, negative effects on cognitive development, and trust issues in close relationships. baby swimming is a structured form of interaction that takes place in 34-degree celsius water in a calm environment, aiming to teach the baby vital skills while stimulating social, intellectual, and motor development. at least one parent actively participates and is encouraged to perform various exercises. these activities strengthen the bond between the baby and the parent and contribute to making time in the water a safe and enjoyable experience. previous studies have shown that baby swimming can improve attachment between parent and child. in the present project, the aim is to investigate whether baby swimming can be used as an intervention for depressive symptoms in new mothers and whether this intervention can reduce depressive symptoms while also strengthening the bond between mother and child.


Eligibility criteria:
inclusion criteria: women who have * given birth at full term * are 18 years or older * have a baby aged 3-7 months at the time of inclusion * exhibit depressive symptoms according to the epds scale. exclusion criteria: * multiple pregnancy (twins, triplets) * known psychotic disorder or bipolar disorder * inability to communicate adequately in swedish or english, or inability to read and complete digital questionnaires in swedish or english.

Keywords: depression attachment postpartum baby swimming
pedestrian behavior following implementation of a walking school bus

Conditions: Obesity

Summary: the purpose of this study is to determine whether a walking school bus program can increase the number of children walking to school and decrease the number of children driven by car to school.

walking to school is associated with higher levels of physical activity, which is an objective of healthy people 2010. however, parents' concerns about safety have been identified as a barrier that prevents their children from walking to school. a walking school bus (wsb) addresses these concerns by providing a supervised period of physical activity on the way to school. a wsb is a group of children led to and from school by responsible adults who walk together along a set route. the peer-reviewed literature on active travel to school is sparse. we evaluated a wsb program, to test the hypothesis that it would increase the proportion of children walking and decrease the proportion of children driven by car to school. comparison: we conducted an 18-month controlled, quasi-experimental trial at three public elementary schools in seattle, washington. the intervention school was assigned a wsb coordinator who dedicated 10-15 hours/week establishing wsb routes and implementing school activities on pedestrian safety. each "bus" had its own set route to school from different locations in the surrounding neighborhoods and was staffed by several parent leaders. the two control schools received standard seattle public schools resources on walking to school including "safe route maps," a traffic and safety committee, and school safety patrols. the primary outcomes were the proportions of children who walked with and without an adult or were driven by car to school. we used the test for independent proportions to compare the proportion of children transported to school at the intervention versus control schools.

Eligibility criteria:
inclusion criteria: * enrolled in school * present on the day of the survey at one of 3 study schools. exclusion criteria: * absent on the day of the survey at one of 3 study schools.

Keywords: walking motor activity students schools transportation motor vehicles
bacillus coagulans effect on gastrointestinal function in healthy adults.

Conditions: Digestive Discomfort; Constipation; Microbiota

Summary: a single centre, double-blind, placebo-controlled study to evaluate the effect of the consumption of bacillus coagulans at a daily dose of 1 x 10⁹ cfu on bowel habits, intestinal microbiota and gastrointestinal symptoms in healthy adults.


Eligibility criteria:
inclusion criteria: 1- adults male or female aged 18-65 years old. 2- generally healthy but with irregular bowel movements, including \&lt;4 stools/week or periodic (over 2/week) loose stools 2- agreed not to take other probiotics or prebiotics products during the study period, unless specified by the investigator. 3- subjects enrolled in the study voluntarily and signed the consent form. exclusion criteria: 1. subjects aged \&lt;18 or \&gt; 65 years, pregnant or lactating women, and those who are susceptible to allergens or have food allergies. 2. subjects with cardiovascular, cerebrovascular, hepatic, renal, hematopoietic diseases or endocrine diseases, and or mental illness. 3. subjects with constipation symptoms caused by surgical operation within the past 30 days; subjects with acute gi track diseases in the past 30 days; subjects with constipation symptoms due to severe organ lesion (colon cancer, severe enteritis, intestinal obstruction, inflammatory bowel disease, etc.) 4. subjects who could not eat orally or take the study products as prescribed or cannot comply with the protocol. 5. subjects administered relevant products recently, which would affect the outcome of the study. 6. subjects who took probiotics or prebiotics products (including yogurt, beverages or foods containing probiotics) within the past month, which may affect the results of the study. 7. subjects who suffered from gastrointestinal disease within the past month. 8. subjects who had taken antibiotics in the past month. 9. subjects who had not taken the test product as prescribed or took other supplements or drugs. 10. subjects with incomplete data or incomplete information, so that the efficacy could not be estimated.

Keywords: gi microbiota, bowel habits, gi symptoms
a phase iii study of sm-13496 in patients with bipolar i depression.

Conditions: Bipolar Depression

Summary: the study evaluates the efficacy and safety of sm-13496 compared with placebo in patients with bipolar i depression.

the primary objective is to compare the efficacy of sm-13496 (20-60 or 80-120 mg/day) monotherapy with that of placebo in patients with depressive symptoms associated with bipolar i disorder by assessing the change from baseline in the madrs total score at week 6.

Eligibility criteria:
inclusion criteria: * patients who were fully informed of and understand the objectives, procedures, and possible benefits and risks of the study and who provided written voluntary consent to participate in the study. * outpatients aged 18 through 74 years at the time of consent * patients meets dsm-iv-tr criteria for bipolar i disorder, most recent episode depressed (≥ 4 weeks and less than 12 months) without psychotic features. exclusion criteria: * patients with imminent risk of suicide or injury to self, others, or property. * patients who had been hospitalized because of a manic or mixed episode within 60 days prior to screening. * patients who are otherwise considered ineligible for the study by the investigator.
impact of the operator performing oocyte retrieval on the cumulative live birth rate

Conditions: Infertility (IVF Patients); Oocyte Retrieval

Summary: this is a monocentric retrospective observational study. the study investigates the impact of the operator performing the oocyte retrieval on the cumulative live birth rate (clbr). the objectives of the study are as follows: * to evaluate whether the operator performing the oocyte retrieval influences the probability of pregnancy, expressed as the cumulative live birth rate (clbr). * to assess whether operator performance improves with increased experience. to address the study objectives, data will be collected using a specific internal web-based database. all oocyte retrieval procedures performed at the humanitas fertility center from january 2013 to december 2022 will be included in the evaluation. outcomes will be expressed in terms of clbr.


Eligibility criteria:
inclusion criteria: the study database will include patients who underwent oocyte retrieval procedures with the intention of achieving pregnancy at the humanitas fertility center between january 2013 and december 2022, including repeated art cycles. operator experience will be assessed based on the number of previously performed oocyte retrieval procedures. all operators who performed at least 50 procedures, either at irccs - humanitas research hospital or at another institution, will be included in the study. exclusion criteria: patients who underwent preimplantation genetic testing (pgt) cycles, as well as those who underwent cryopreservation for oncological or elective purposes, will be excluded from the study. operators who performed fewer than 50 oocyte retrievals, either at irccs - humanitas research hospital or at another institution, will be excluded. additionally, the first 50 procedures performed by each operator will not be included in the dataset.
the homburg keratoconus center (hkc)

Conditions: Keratoconus

Summary: aim of this study is to conduct longitudinal and cross-sectional analyses about the corneal ectatic disease keratoconus based on data obtained from keratoconus patients in the homburg keratoconus center (hkc). the homburg keratoconus center (hkc) was founded in 2010 and, up to now, comprises more than 3,000 keratoconus patients. topographic, tomographic and biomechanic characteristics of the disease are being analyzed with the intention to elucidate how the disease begins and develops during lifetime.


Eligibility criteria:
inclusion criteria: * all keratoconus patients presenting in the department of ophthalmology, saarland university medical center, homburg, saarland, germany. exclusion criteria: * patients without keratoconus.

Keywords: keratoconus crosslinking intracorneal ring segments gas-permeable rigid contact-lenses penetrating keratoplasty deep anterior lamellar keratoplasty abcd grading system
efficacy and safety of basiliximab in hepatitis c virus positive patients undergoing liver transplantation

Conditions: Liver Transplant

Summary: the natural history of hcv infection in liver transplant recipients may be accelerated when compared to that in patients with normal immune systems. the objective of this trial is to assess the efficacy and safety of basiliximab, in combination with cyclosporin and mmf on the success rate of liver transplants for hcv related cirrhosis, in comparison with standard steroid treatment.


Eligibility criteria:
inclusion criteria patients undergoing first cadaver liver transplant patients receiving an ab0 identical or compatible graft hcv+ patients (serology test within the last 12 months) exclusion criteria antiretroviral prophylactic treatment post-transplant serological markers positive for hepatitis b surface antigen and human immunodeficiency virus recipients of a split liver transplant other protocol-defined inclusion/exclusion criteria applied

Keywords: liver transplant, hcv+, steroid free
the effect of simulation in gaining skills to nursing students

Conditions: Dementia; Nursing Caries

Summary: this research is a randomized controlled study conducted to examine the effect of standard patient simulation training in providing nursing students with the ability to care for individuals with dementia. the population of the research consisted of 100 students who were enrolled in the nursing faculty and took the "psychiatric nursing" course in 2020-2021 academic year. 84 students who were in the universe and completed the pre-test were randomly assigned to the experimental groups that received simulation training and the control groups that did not receive simulation training. the study was completed with 36 students in the experimental group and 35 students in the control group. research data were collected with "personal coding system and scale cover document", "structured student information form", "dementia information test", "case study form for individuals diagnosed with dementia", "standardized mini mental examination", "communication skills evaluation form", nursing diagnosis detection skill form" and "modified-simulation effectiveness tool".


Eligibility criteria:
inclusion criteria: * registered in hamidiye faculty of nursing, * taking a psychiatric nursing course in the spring semester of the 2020-2021 academic year, * do not have a communication problem at a level that prevents meeting, * students who volunteered to participate in the study were included in the study. exclusion criteria: * not registered in hamidiye nursing faculty, * those who did not take a psychiatric nursing course in the spring semester of the 2020-2021 academic year, * having a communication problem at a level that prevents meeting, * students who did not volunteer to participate in the study were excluded from the study.

Keywords: dementia patient simulation nursing education nursing student simulation training
prospective evaluation of fibroscan in patients treated with methotrexate

Conditions: Liver Fibrosis

Summary: the aim of this study is to evaluate liver fibrosis using fibroscan and biochemical markers in patients treated with methotrexate.

methotrexate (mtx) is an effective treatment for induction of remission and maintenance in patients with crohn's disease, rheumatoid arthritis, or psoriasis which may induce liver fibrosis with high cumulative doses. transient elastography (fibroscan) is a new non-invasive rapid, reproducible and bed-side method, allowing assessment of liver fibrosis by measurement of liver stiffness. a preliminary study (laharie et al, alimentary pharmaceutical therapeutics 2006) had shown that significant liver fibrosis was rare in crohn's disease patients treated with a high dose of methotrexate. fibroscan was a reliable non-invasive method to detect liver fibrosis which could be recommended in these patients. therefore, liver biopsy could be performed only with patients with high fibroscan values and/or with chronic liver enzymes abnormalities. however, further longitudinal and prospective studies are mandatory to confirm these preliminary data, in patients with crohn's disease but also with rheumatoid arthritis and psoriasis.

Eligibility criteria:
inclusion criteria: * male or female subjects, ≥18 years of age. * patient treated with methotrexate. * written informed consent exclusion criteria: * patients refusing to participate to the study and to provide written informed consent * pregnant women

Keywords: liver fibrosis, cirrhosis fibroscan transient elastography elastometry methotrexate non invasive blood markers fibrotest treatment
supervised versus non-supervised exercise on adherence and functional outcomes in colorectal patients

Conditions: Colorectal Cancer

Summary: investigation into prehabilitation by increasing the supervision of exercise in patients undergoing colorectal resection for cancer and comparing with patients involved in a rehabilitation group receiving exercise after surgery.

the aims of this research project are the following: to determine to what extent a structured multimodal prehabilitation regimen, which includes aerobic and resistance exercise, nutritional supplementation and psychological coping strategies, initiated before surgery, and continued while in hospital and after surgery, optimizes the recovery of functional walking capacity following colorectal resection for cancer. to understand which measures of immediate surgical recovery are sensitive to prehabilitation interventions and predict change in later outcome measures.

Eligibility criteria:
inclusion criteria: * referred electively for resection of malignant, non metastasized, colorectal lesions. * french or english speaking exclusion criteria: * asa class 4-5 * co-morbid medical, physical and mental conditions (e.g. dementia, disabling orthopedic and neuromuscular disease, psychosis) * cardiac abnormalities * severe end-organ disease such as cardiac failure (new york heart association classes i-iv), copd, renal failure (creatinine \> 1.5mg/dl, and hepatic failure alt and ast \> 50% over the normal range) * sepsis * morbid obesity (bmi \> 40) * anemia (hematocrit \< 30%, haemoglobin \< 10g/dl, albumin \< 25mg/dl).
precision grx registry

Conditions: Coronary Artery Disease

Summary: to collect data on the routine patterns of use, safety and effectiveness, including the clinical and technical performance of the corpath grx system, in the delivery and manipulation of coronary guidewires and stent/balloon catheters, and manipulation of guide catheters during pci procedures.

this is a single-arm, open-label, multi-center patient registry of the corpath grx system to examine its performance during pci procedures and patient outcomes through 72 hours post-procedure or hospital discharge, whichever occurs first.

Eligibility criteria:
inclusion criteria: candidates will be included in the study only if all of the following conditions are met: 1. age ≥18 years; 2. patients with coronary artery disease with clinical indication for pci; 3. patient deemed appropriate for robotic-assisted pci; and 4. the subject has been informed of the nature of the study, agrees to its provisions and has provided written informed consent. exclusion criteria: * candidates will be excluded from the study if any of the following conditions are present: 1. failure/inability/unwillingness to provide informed consent; or 2. the investigator determines that the patient or the coronary anatomy is not suitable for robotic-assisted pci.
phacoemulsification at high iop and physiologic iop: impact on anterior and posterior segment physiology

Conditions: Nuclear Cataract

Summary: the purpose of this study is to investigate the anterior and posterior structure and functional changes and vascular alterations when performing phacoemulsification at high iop vs low, more physiological iop using centurion® vision system with active sentry® handpiece. these devices are approved by the us food and drug administration (fda).

to investigate the anterior and posterior physiological changes when performing phacoemulsification at high iop vs low, more physiologic iop using centurion® vision system with active sentry® handpiece prospective, single-surgeon, randomized, paired-eye study; patients undergoing sequential, uncomplicated bilateral phacoemulsification using active sentry handpiece® with intraocular iop ≤ 28mmhg (low iop) in one eye and with iop ≥ 60mmhg (high iop) in the other eye operating at lower, more physiological iop using active sentry® handpiece during cataract surgery will use less bss fluid usage. (lower iop settings are also expected to result in less subclinical changes).

Eligibility criteria:
inclusion criteria: * no prior ocular surgery including corneal refractive surgery * bilateral visually significant cataract, similar in density (locs iii grade 2+), undergoing uncomplicated cataract surgery * equal dilated pupil size ≥6mm, no use of pupil expansion devices * unremarkable systemic health but inclusive of controlled type ii diabetes and hypertension with normal oct angiography at baseline * a1c ≤ 8% on single monotherapy or lifestyle adjustments * to maintain high sensitivity/specificity, patients to fall under oct normative database: * axial length 22-26mm * refractive error between -5.00d to +5.00d * cylinder ≤ 3.00d * normal k values \<47.00d * axial eye length cannot vary by more than 0.4 mm in an individual patient * normal cct range 540µm ± 50 exclusion criteria: * h/o corneal disease or dystrophies * media opacification for reasons other than cataract * compromised zonular integrity or stability * retinal and retinal vascular pathologies, age-related macular degeneration * glaucoma * patients with uncontrolled systematic diseases; including hypertension, diabetes, systemic cardiovascular diseases and hematological diseases
feasibility study of duloxetine in the treatment of depression in patients with traumatic brain injury

Conditions: Traumatic Brain Injury; Depression

Summary: the primary objective of the study is to compare the efficacy of duloxetine 60 mg by mouth daily with placebo in the prevention of depression associated with mild/moderate traumatic brain injury and to enhance cognitive function.

the primary objective of the study is to compare the efficacy of duloxetine 60 mg by mouth daily with placebo in the prevention of depression associated with mild/moderate traumatic brain injury and to enhance cognitive function. research exploring the use of selective serotonin reuptake inhibitors in the treatment of post-traumatic depression generally validates this approach (horsfield et al., 2002). however, the literature suggests that serotonin/norepinephrine reuptake inhibitors such as duloxetine may be more effective in the treatment of depression.

Eligibility criteria:
inclusion criteria: * study participants will be 40 men and women between the ages of 18 and 75 who provide appropriate consent and who are agreeable to study requirements * diagnosed with mild to moderate traumatic brain injury as defined by an initial mayo traumatic brain injury severity scale * have memory impairments defined by a hopkins verbal learning test delayed recall score which falls less than or equal to 1.5 standard deviation below the mean. exclusion criteria: * refusal to give informed consent * a previous central nervous system illness or injury, including seizure that exhibits residual symptoms. * current post-traumatic seizure disorder * a previous diagnosis of a psychotic disorder * current or previous (in the last 6 months) treatment history for alcohol or substance dependency * medications affecting noradrenergic or dopaminergic systems, alpha-adrenergic antihypertensives, antidepressant, phenobarbital, monoamine oxidase inhibitor (maoi), scheduled benzodiazepines, psychoactive herbal supplements (including kava, st. john's wort), or nutritional supplements or within at least 14 days of discontinuing treatment with the above medications or supplements. * a known suicide risk * a pregnant or breastfeeding woman * uncontrolled narrow-angle glaucoma * serious and/or unstable medical comorbidity (e.g., aids, cancer, history of uncontrolled hypertension or cardiovascular disease) psychological condition, or clinically significant laboratory abnormality that in the opinion of the investigator would compromise participation in the study or be likely to lead to hospitalization during the course of the study * liver enzymes \> 1.5 times upper limit of normal * patients with end-stage renal disease (requiring dialysis) or severe renal impairment * known hypersensitivity to duloxetine or any of the inactive ingredients

Keywords: depression traumatic brain injury duloxetine cymbalta impaired cognitive function