Kornimate/medical-research-clean huggingface dataset:
minimally invasive versus conventional approaches in navigated total knee arthroplasty (tka)

Conditions: Osteoarthritis; Rheumatoid Arthritis; Post-traumatic Arthritis

Summary: 50 patients are randomized to two groups who receive a navigated knee prosthesis. aim of the study is a comparison between a minimally invasive and a conventional approach. in both groups orthopilot computer assisted-navigation will be used. pain intensity as well as concomitant pain medication are monitored during the first 20 postoperative days and will be compared for the two groups. various scores are surveyed.

accuracy of implant positioning and reconstruction of the mechanical leg axis are major requirements for achieving good long-term results in total knee arthroplasty (tka). a minimally invasive approach might compromise the accuracy due to lacking intraoperative oversight. the purpose of this study is to compare a minimally invasive tka approach that was performed under control of a navigation system with a standard navigated approach, with respect to patient pain and range of motion. all patients receive a columbus knee prosthesis and in both groups an orthopilot navigation system is used to control the alignment. pain intensity using the visual analogue scale (vas) and concomitant pain medication intake are documented daily during the first 20 days after operation. as long as the patient is hospitalized the range of motion will also be documented daily. knee society score, oxford score, as well as the womac score are monitored pre- and postoperatively.

Eligibility criteria:
inclusion criteria: * indication for elective tka * agreement to participate in this study exclusion criteria: * body mass index (bmi)\>40kg/m² * varus or valgus deformity \>20° * range of motion (rom) \<75° flexion/extension * concomitant diseases like: rheumatoid arthritis osteoporosis intake of cortisone diabetes former operations on the concerned knee * infections in the operated joint during the follow-up period * thromboses during the follow-up period

Keywords: surgical procedures, minimally invasive range of motion articular arthroplasty, replacement, knee
the effectiveness of advanced decision support tool (opt-ivf) for ivf treatment

Conditions: Fertility Issues

Summary: this prospective study is subject to approval of institutional medical research ethics committee. patient undergoing second cycle ivf will be enrolled into the intervention group. intervention involved using a clinical decision support tool, opt-ivf to guide gonadotrophins dosing and trigger dates for a personalized controlled ovarian stimulation cycle based on the distribution of follicle sizes on day 1 and day 5, and hormone dosages given on day 1 to 4. patients will undergo transvaginal ultrasound exam on day 1 and day 5 of the cycle to determine the number and size of follicles present. the data is used in the opt-ivf decision support tool to suggest gonadotropin dosage for d5 and beyond and to recommend the antagonist start day and trigger day. clinical investigators will not override the opt-ivf recommended dosage in any patients.

the total dosage of gonadotrophin, number of good quality oocytes and blastocyst will be analyzed from each arm.

Eligibility criteria:
inclusion criteria: * patient undergoing 2nd cycle of ivf exclusion criteria: * polycystic ovarian syndrome patient
effects of physical training in altered environmental conditions on exercise performance

Conditions: Hypoxia, Altitude; Cold Exposure; Heat Exposure

Summary: the main objective of the study is to evaluate the physiological-biochemical effects of physical training under artificially altered climatic conditions (using a hypoxic thermoclimatic chamber) in particular to determine the effect of such training on exercise capacity and physiological response, including the effect of training in high-performance athletes. the study will evaluate the effects of physical training and the simultaneous application of hypoxia and heat/cold on aerobic and anaerobic capacity and the physiological response of the human body. the aim of the study is to find the most favourable environmental conditions for physical training in order to maximise physical performance.


Eligibility criteria:
inclusion criteria: absence of medical contraindications to high-intensity physical exertion. the medical examination is required (included an exercise ecg, blood tests to exclude anemia or low hemoglobin and iron concentration) exclusion criteria: any training (including hypoxia training or exposure) performed in the 6 months prior to the beginning of the intervention

Keywords: training exercise human performance aerobic capacity anaerobic capacity maximal oxygen uptake muscle power
express implant versus trabeculectomy after late failure trabeculectomy

Conditions: Glaucoma

Summary: to compare between outcome of express implant and subscleral trabeculectomy (sst) in management of glaucoma after previous trabeculectomy with a fibrotic bleb.

trabeculectomy is the main glaucoma surgery. despite the good decline in intraocular pressure (iop) that occur rapidly after the procedure, there is still failure occurring due to progressive subconjunctival fibrosis, with associated increased iop. if the bleb is revived by needling with adjunctive 5-fluorouracil (5fu) and mitomycin c (mmc) that used intraoperatively for the majority of these cases , the associated rise in iop was controlled if the revision occured early within the first three months after surgery. but less success occurred if the bleb revision was delayed. if these interventions fail, alternative approaches include new augmented trabeculectomy or aqueous shunt implantation. express shunt allows aqueous to pass from anterior chamber to subconjunctival space like trabeculectomy .express shunt is a non valved shunt, it has an advantage of less traumatic, less complications, low diffuse bleb and high success rate.

Eligibility criteria:
inclusion criteria: * elevated intraocular pressure (iop) with fibrotic bleb despite previous sst since more than 4 months * follow up 12mo after the second surgery exclusion criteria: * sst failure other than fibrotic bleb were also excluded * follow up less than 4mo after the first surgery, and those less than 12mo after the second surgery

Keywords: express valve failed trabeculectomy
relevance of sensitization to fenugreek in children

Conditions: Allergy to Fenugreek

Summary: the prevalence of allergy to legumes is inscreasing, especially in children and for some of these legumes, little is known and there are not included in the list of priority allergen. the overall goal of this study is to improve knowledge about fenugreek allergy. the principal aim is to evaluate the prevalence of allergy to fenugreek confirmed by a positive oral food challenge in children sensitized to fenugreek. the secondary objectives are to describe the case of allergy to fenugreek (co-allergies, severity, age..), to evaluate diagnostic values of skin prick-tests and specific ige and to compare the molecular profile of specific ige to peanut between sensitization to fenugreek without allergy and sensitization with a confirmed allergy


Eligibility criteria:
inclusion criteria: * children for whom an oral food challenge to fenugreek has been performed between the 1st january 2017 and the 15th april 2022 and for whom skin prick test and/or specific ige to fenugreek are avalaible exclusion criteria: * patient over 18 years old * undeterminate oral food challenge

Keywords: allergy children legumes sensitization diagnostic
planned non-operative management for rectal cancer

Conditions: Rectal Cancer

Summary: the investigators propose to conduct an observational study on consecutive patients with low-lying or mid rectal cancers smaller than 5 cm in length and less than 50% of rectal circumferential extent. the aim of this study is to test a hypothesis that escalation of either radiation or chemotherapy dose of the routine preoperative radio(chemo)therapy leads to an increase of clinical complete response rate. the planned sample size of 23 patients was calculated based on the assumption that clinical complete response rate after routine preoperative radio(chemo)therapy is 34% \[1\] and expected rate after radio(chemo)therapy dose escalation is 75% \[2-4\]. an endorectal high dose rate iridium brachytherapy boost (2 fractions of 10 gy) will be added after the routine preoperative treatment consisted of external beam radiotherapy (5 × 5 gy) combined with sequential 3 cycles of consolidation folfox4. however, for patients with involvement of the anal canal, additional 3 cycles of consolidation folfox4 (6 cycles in total) will be added instead of brachytherapy boost to avoid severe post-radiation toxicity.


Eligibility criteria:
inclusion criteria: 1. adenocarcinoma of the rectum classified clinically as t2, t3a-c or t4b but only with superficial infiltration of the vagina or prostate; tumour accessible by digital rectal examination; tumour ≤5 cm in length and ≤50% of rectal circumferential extent; n0-n2, but mesorectal node \<7 mm and no lateral nodes enlargement); extramural vascular invasion but not larger than 7 mm in the largest dimension; m0. 2. operable patient 3. patient having read the information note and having signed the informed consent 4. follow-up possible exclusion criteria: 1. inoperable patient 2. ct1, ct3d, large t4, tumour ≥5cm or ≥50 of rectal circumferential extent 3. enlargement of lateral nodes or any node ≥8 mm in diameter 4. patient presenting metastasis at diagnosis 5. previous pelvic irradiation 6. simultaneous progressive another cancer 7. close follow-up uncertain.

Keywords: rectal cancer non-operative management
bupivicain vs bupivicain plus dexamethasone in esp block for post-op analgesia

Conditions: Post Operative Pain

Summary: thoracotomy is a very painful procedure. different treatment modalities are being utilized for post-thoracotomy analgesia including i/v nsaid, opoids and neuropathic medications. other techniques commonly utilized include thoracic epidural, paravertebral block; but both are associated with significant failure rate and other complications. ultrasound guided erector spinae plane block is a new regional anesthesia technique that provides analgesia at multidermatomal levels acriss the posterior, lateral and anterior thoracic walls. the rational of my study is that it is a novel technique and studies with bupivicain alone are present but no study was found with bupivicain plus dexamethasone.


Eligibility criteria:
inclusion criteria: * age 18-60years asa i-iii patients undergoing elective thoracotomies exclusion criteria: * refusal of patient coagulation disorders known allergy to local anesthetics infection at the site of injection pregnant females morbid obesity(bmi\>40kg/m2) psychiatric illness diabetic patients.

Keywords: erector spinae plane block, thoracotomy, ultrasound
trial of shr-1701 plus bp102 in subjects with selected solid tumors

Conditions: Advanced Solid Tumors

Summary: the main purpose of this study was to assess the safety, tolerability, and efficacy when combining shr-1701 and bp102 in participants with certain cancers. this study was conducted in 2 phases, phase ib and phase ii.


Eligibility criteria:
inclusion criteria: 1. histologically or cytologically confirmed solid malignancy that is metastatic or unresectable for which standard curative or palliative measures do not exist or are no longer effective (phase ib) 2. histologically or cytologically confirmed metastatic or locally advanced solid tumors of the selected indications. (phase ii). 3. .life expectancy exceeds 12 weeeks; 4. the eastern cancer cooperative group (ecog) has a performance score of 0 or 1; 5. normal organ and marrow function; exclusion criteria: 1. has known active central nervous system (cns) metastases. subjects with previously treated brain metastases may participate provided they are stable. 2. a history of human immunodeficiency virus (hiv) infection is known, or has an active autoimmune disease. 3. history of interstitial lung disease or pneumonia requiring oral or intravenous steroids. 4. has moderate or severe cardiovascular disease; 5. active hbv(hepatitis b) or hcv (hepatitis c virus)-infected subjects; 6. any other malignancies within 5 years except for those with negligible risk of metastasis or death.
human repeated insult patch test

Conditions: Dermatitis; Allergy; Contact Allergy

Summary: repeated insult patch test on healthy males and females to determine potential contact irritation or contact allergy in the skin


Eligibility criteria:
inclusion criteria: * adults; * subjects must understand and execute an informed consent form that includes a hipaa statement; * subjects must be considered dependable and able to follow directions exclusion criteria: * subjects who are in ill health; * subjects who are taking medications other than birth control; * female subjects who are pregnant (return positive urine pregnancy test), planning to become pregnant or lactating during the course of the trial; * subjects who have a history of adverse reactions to personal care products, or known sensitivity to the test materials or their constituents including patch materials; * subjects with any active skin disease; * subjects who have heavy alcohol consumption; * subjects with current use or history of repeated use of street drugs; * subjects with a significant past medical history to potentially effect results of study; * subjects with immunization less than 10 days prior to the test patch application;
evaluation of hand grip strength in pregnant covid-19 patients

Conditions: COVID-19; Pregnancy Related

Summary: it was presented as a cross-sectional, single-center, retrospective case series. pregnant women with a positive polymerase chain reaction (pcr) diagnosis of covid 19 were included in the study. the relationship between patients' musculoskeletal symptoms and signs and hand grip strength was investigated.

covid 19 is the disease defined for strains infected with severe acute respiratory syndrome coronavirus 2(sars-cov-2). hand grip strength is a non-invasive, easily applicable, objective parameter. it was presented as a cross-sectional, single-center, retrospective case series. pregnant women with a positive polymerase chain reaction (pcr) diagnosis of covid 19 were included in the study. the relationship between patients' musculoskeletal symptoms and signs and hand grip strength was investigated.

Eligibility criteria:
inclusion criteria: * pregnant women with a positive polymerase chain reaction (pcr) diagnosis of covid 19 exclusion criteria: * those with orthopedic defects in the dominant hand and wrist and those with hand, wrist and shoulder involvement on the side of the measurement related to rheumatological diseases were excluded from the study.

Keywords: covid-19 musculoskeletal symptom hand grip muscle streng
non-contact air tonometry (topcon ct-1®) versus goldmann

Conditions: Glaucoma

Summary: in this prospective device comparison study with 58 healthy eyes, the topcon ct-1® showed statistically significant elevated intraocular pressure measurements compared to the gold standard goldmann application tonometry.

introduction: intraocular pressure (iop) measurement is crucial in glaucoma diagnosis and treatment. we compared a non-contact air tonometer (topcon ct-1®) with the gold standard goldmann applikation tonometer (gat). methods: in this prospective, mono centric device comparison study, only healthy eyes were enrolled. iop was measured three times with the topcon ct-1® followed by three times gat. mean iop was calculated and compared with a paired t-test, a linear regression and a bland-altman analysis.

Eligibility criteria:
inclusion criteria: healthy volunteers who agreed to be included in the study and were able to comply with the measurement procedures exclusion criteria were cor-neal abnormalities (such as oedema, scars or dystrophies, astigmatism,hyperopia or myopia \> 3 dioptres), a history of ocular surgery or recent(\<47 weeks) ocular disorder.

Keywords: tonometry
the effect of splint usage in laterognathic cl iii orthognathic surgery patients

Conditions: Skeletal Malocclusion; Class III Malocclusion; Laterognathia

Summary: it is crucial to maintain the anatomic condylar positions during orthognathic surgery. condylar positions are affected directly under general anesthesia because of joint and muscle relaxation. possible unwanted changes in the joint position may cause incorrect positioning of the jawbones. this could affect the success of the surgery in terms of function and facial aesthetics causing the need for a second surgery. our aim is to evaluate whether the use of mr splint has a statistically significant effect on muscle relaxation-induced condyle position deviations under general anesthesia in class iii laterognathia patients.

it is crucial to maintain the anatomic condyle positions during orthognathic surgery to prevent iatrogenic temporomandibular joint complications. condyle shunts are affected directly under general anesthesia because of the joint and muscle relaxation. surgical guidance appliances are prepared according to the tmj records taken chairside while patients are in an upright position. during surgery, these appliances are applied in a supine position while the muscles are relaxed. postoperative and long-term effects of tmj and muscle relaxation obtained under general anesthesia in class iii and asymmetric patients will be examined. patients who had occlusal splint before records taken will be evaluated in terms of condyle location by mpi. our aim is to evaluate whether the use of mr splint has a statistically significant effect on muscle relaxation-induced condyle position deviations under general anesthesia in class iii laterognathia patients.

Eligibility criteria:
inclusion criteria: * being ready for orthognathic surgery * must be able to give centric relation records exclusion criteria: * having any tmdsyndromes * cleft lip and palate, * have bruxism, * tmj or muscle disfunctions, * under any medication of muscle relaxants, * narcotics and antidepressants, * usage of removeable prosthetics * have toothless areas that can affect the wax impression for centric record * used horizontal elastics within the last 2 months
diva study - a study of different regimens of intravenous administration of bonviva (ibandronate) in women with post-menopausal osteoporosis

Conditions: Post Menopausal Osteoporosis

Summary: this study will assess the efficacy and safety of intravenous administration of bonviva regimens in women with post-menopausal osteoporosis, compared to oral daily administration. patients will also receive daily supplementation with vitamin d and calcium. the anticipated time of study treatment is 2+ years, and the target sample size is 500+ individuals.


Eligibility criteria:
inclusion criteria: * women 55-80 years of age; * post-menopausal for \>=5 years; * ambulatory. exclusion criteria: * malignant disease diagnosed within the previous 10 years (except basal cell cancer that has been successfully removed); * breast cancer within the previous 20 years; * allergy to bisphosphonates; * previous treatment with an intravenous bisphosphonate at any time; * previous treatment with an oral bisphosphonate within the last 6 months, \>1 month of treatment within the last year, or \>3 months of treatment within the last 2 years.
safety and efficacy study of daclatasvir (bms-790052) plus pegylated interferon-alfa 2a and ribavirin in patients coinfected with untreated hepatitis c virus and hiv virus

Conditions: Hepatitis C, Genotype 1

Summary: the purpose of this open label study is to evaluate the safety and efficacy of daclatasvir plus pegylated interferon-alfa 2a and ribavirin in untreated hepatitis c virus in patients coinfected with hiv


Eligibility criteria:
for more information regarding bms clinical trial participation, please visit www.bmsstudyconnect.com key inclusion criteria: * males and females, 18 to 70 years of age * hepatitis c virus (hcv) genotype 1a or 1b * hcv-treatment naive * hcv rna \>10,000 iu/ml at screening * hiv-1 infection (approximately 250 patients receiving highly active antiretroviral therapy \[haart\], up to 50 patients not receiving haart) * for patients receiving haart, hiv rna must be below \<40 copies/ml at screening and must be \<400 copies/ml for at least 6 months prior to screening key exclusion criteria: * patients receiving haart who first initiated antiretroviral therapy within the last 6 months of day 1 * patients receiving haart who have changed their antiretroviral regimen due to safety or efficacy associated to hiv treatment within the last 3 months prior to day 1. however, if changes are required to a patient's haart regimen to meet the requirements of the protocol, these changes are allowed at the screening visit. the patient should wait a minimum of 1 month prior to day 1 after a repeat of hiv viral load has been confirmed, \<40 copies/ ml * use of prohibited haart regimens within 1 month of day 1 and throughout the treatment period of the trial (patients receiving haart who have changed their antiretroviral regimen to initiate any hcv treatment within 6 weeks prior to day 1) * laboratory values: 1. neutrophil count \<1500 cells/μl (\<1200 cells/ μl for blacks) 2. platelet count \<90,000 cells/μl 3. hemoglobin ≤12 g/dl for females, hemoglobin ≤13 g/dl for males 4. total bilirubin ≥34 μmol/l (or ≥2 mg/dl) unless a patient has a documented history of gilbert's disease or antiretroviral regimen contains atazanavir 5. alanine aminotransferase ≥5\*upper limit of normal
lymphedema therapy with sound wave lymphatic drainage

Conditions: Lymphedema

Summary: lymphedema is a frequent sequela of breast cancer treatment, that can develop up to 40% of patients. lymphedema is the accumulation of protein-rich fluid (lymph) in the interstitial spaces of the affected body part due to a blockage or malfunction in the lymph system. it can appear in the arm, shoulder, breast, or thoracic area. lymphedema swelling causes discomfort and sometimes disability. the treatment of lymphedema associated with breast cancer can include complex decongestive physiotherapy, compression therapy, therapeutic exercises, and pharmacotherapy. in this study two treatments will be compared to reduce lymphedema: the manual lymphatic drainage (standard care) versus the low frequency sound waves.

lymphedema, a sequela of breast cancer and breast cancer therapy, changes functional abilities and may affect a patient's psychosocial adjustment and overall quality of life. lymphedema is the accumulation of lymph fluid in the interstitial space. fluid accumulation in the limbs causes enlargement, often with a feeling of heaviness.chronic inflammation leads to fibrosis of the lymphatics, which compounds the problem. several studies have examined the incidence of lymphedema when axillary radiation is given after axillary dissection vs radiation to an undissected axilla. the risk of lymphedema is higher in women treated with axillary dissection and adjuvant radiation to the axilla, with edema reported in 9% to 40% of patients. patients with lymphedema may report symptoms such as a sensation of arm fullness and mild discomfort, which are seen in the early stages of the condition. joint immobility, pain, and skin changes are noted frequently in the later stages of lymphedema. patients also may be predisposed to infections involving the affected extremity. the treatment of lymphedema associated with breast cancer can include complex decongestive physiotherapy, compression therapy, therapeutic exercises, and pharmacotherapy. manual lymphatic drainage is the standard decongestive therapy. recently, low frequency sound waves has been used to reduce lymphedema. the aim of this study is to compare the efficacy of the manual lymphatic drainage versus the low frequency sound waves.

Eligibility criteria:
inclusion criteria: * lymphedema presence at least for 1 year * no previous treatments for lymphedema in the last 6 months exclusion criteria: * electronic devices or metalic implants * cardiac failure or hypertension * epilepsy * local infection * pregnancy * thrombophlebitis