Kornimate/medical-research-clean huggingface dataset:
effect of pilates and segmental stabilization in elderly people with low back pain

Conditions: Low Back Pain

Summary: introduction: low back pain is an important health condition with great consequences from the socioeconomic point of view and is associated with high costs for the health system, absenteeism at work and reduced functional performance. it is considered one of the most relevant health problems in the elderly, with point prevalence estimates higher than for other musculoskeletal conditions. it can be defined as any pain between the last ribs and the lower gluteal folds, with or without pain in the lower limbs, manifesting itself acutely, subacutely or chronically. objective: to compare the effect of the pilates method versus segmental stabilization in elderly people with chronic low back pain. method: 60 elderly people with chronic low back pain will participate in the study and will be randomized into two groups: pilates group (gp) and segmental stabilization group (sg). the two treatments will have 16 individual sessions, twice a week. pain will be assessed using the visual analogue pain scale; functional disability, using the oswestry disability index; excessive fear of movement and physical activity, by the tampa scale of kinesiophobia; level of confidence in the balance for specific activities, by the abc scale and; activation of the transversus abdominis muscle by pressure biofeedback. individuals will be evaluated in four moments: before the first session, after the last session, three and six months after the end of the treatment to verify the effects in the medium term. patient allocation and assessments will be performed by a blind examiner. data will be analyzed using the anova procedure and tukey's multiple comparison test. the significance level will be 5%. a hipótese deste estudo é que o grupo que realiza exercícios de pilates obtém ganhos mais obtem que o grupo que realiza exercícios de estabilização segmentar em todas as variáveis ao final do tratamento.


Eligibility criteria:
inclusion criteria: * non-specific low back pain for at least 3 months. * intensity of pain equal to or greater than 3 cm. exclusion criteria: * specific low back pain. * neurological involvement (radiculopathy, myelopathy). * previous spinal surgery. * any impediment to performing the exercises. * having had recent surgeries. * being on treatment for low back pain * not having cognitive ability to perform the exercises or be submitted to the proposed assessments * missing appointments three times in a row.

Keywords: chronic pain exercise therapy physical therapy modalities
esan ii - energy sensing in depression

Conditions: Immune System Tolerance; Depression; Obesity; Microbial Colonization; Diet, Healthy

Summary: the purpose of this study is to assess the effects of polyphenols from natural aronia juice on the immune system. therefore, the study aims to distinguish the effects of natural juices that are rich in phytonutrients such as polyphenols and carotenoids in healthy and depressive subjects in order to use the known positive effects of these food sources in the therapeutic setting. the consumption of natural fruit juices that are rich in polyphenols and carotenoids mirror a model of vegetarian diet due to the increased micronutrient density derived from plant food. results obtained here can be seen as preliminary explanation models for the beneficial effects of vegetarian diet. it is hypothesized, that the consumption of naturally polyphenol rich aronia juice changes the expression of regulatory t cells, specific cells of the immune system that contribute to immunomodulation. furthermore, beneficial changes in the gut microbiome, the metabolome and the nutritional status are expected in the studied groups. the study was registered retrospectively (after start of recruitment) on clinicaltrials.gov.


Eligibility criteria:
inclusion criteria: 1. socio-demographic criteria: 1. gender: female 2. age: 18-40 years 2. confirmation of the study settings 1. receives of information on * the aims, * methods, * anticipated benefits, * potential risks, and * entailed discomforts of the study 2. signed declaration of consent 3. subgroup of depressive patients: 1. diagnosis of depression according to the icd-10 criteria for depression 2. diagnosed by an experienced psychiatrist * a structured diagnostic interview * voluntarily agreement to participate * signed informed consent 4. subgroup of normal weight participants: * who criteria for normal weight (body mass index (bmi) 18.5-24.99 kg/m2) 5. subgroup of obese participants * who criteria for obesity (bmi \< 30.0 kg/m2) exclusion criteria: 1. formal criteria: * lack of informed consent 2. health criteria 1. alcohol- or drug abuse 2. major cognitive deficits (which do not allow adequate testing) * according to mini mental status examination (mmse) \<20 3. patients which are currently in the locked ward of the clinic 4. acute or chronic diseases or infections within the previous two months * upper respiratory tract infections * fever * chronic inflammatory disorders * autoimmune-disorders * blood diseases * mitochondrial diseases 3. digestive disorders 1. fructose intolerance 2. history of digestive diseases such as * inflammatory bowel disease * irritable bowel syndrome 3. treatment that may has influenced the microbiome * antibiotic or antifungal treatment within the previous two months * daily or irregular intake of prebiotics or probiotics within the previous two months (the intake of yoghurt and dairy products are permitted) 4. history of gastrointestinal surgery (other than appendectomy) 4. pregnancy and period of breastfeeding

Keywords: polyphenols aronia melanocarpa immunomodulation plant based food natural food
effects of macronutrients on hepatic lipids, plasma triglycerides, and insulin sensitivity

Conditions: Metabolic Syndrome X; Liver Diseases

Summary: the purpose of this study is to assess how the macronutrient composition of the diet effects * lipid and glucose metabolism * intrahepatic lipids * insulin sensitivity in healthy lean subjects and in subjects with a high metabolic risk (ie overweight and offsprings of patients with type 2 diabetes mellitus).

the study is aimed at assessing the effects of changes in total energy, sugars, lipids, and protein intake on intrahepatic lipids, plasma lipids, and hepatic and whole body insulin resistance in * lean men and women with no family history of diabetes * overweight men and women * lean men with a family history of type 2 diabetes subjects are studied after a 6-day period of * isocaloric diet with 100% calorie requirement, of which 55% carbohydrate, 15% protein, and 30% fat) * the same isocaloric diet supplemented with 3g/kg body weight/day fructose * hypercaloric high fat diet with 130% energy requirement, of which 55% carbohydrate, 15% protein, 60% fat * hypercaloric high fat+protein diet with 145% energy requirement, of which 55% carbohydrate, 30% protein, 60% fat measurements performed after 6 days on each diet include * intrahepatic and intramyocellular lipids (1h-mrs) * hepatic and whole body insulin sensitivity (hyperinsulinemic-euglycemic clamp) * body weight * plasma concentrations of hormones and substrates * gene expression profile in skeletal muscle (vastus lateralis) and adipose tissue (subcutaneous abdominal)

Eligibility criteria:
inclusion criteria: * males and females * age 18-40 * informed consent obtained * subgroup with overweight (body mass index \[bmi\] \> 25) * subgroup with family history of type 2 diabetes mellitus exclusion criteria: * smokers * alcohol intake \> 30g/day * drug abuse * diabetes mellitus * any concurrent medication * having a pacemaker * history of orthopedic surgery * history of metal foreign bodies

Keywords: fructose dietary lipids dietary proteins hepatic steatosis insulin resistance healthy humans overweight humans obese humans
intracept minimally-invasive procedure for vertebrogenic back pain

Conditions: Chronic Low-back Pain; Vertebrogenic Pain Syndrome

Summary: compile real-world outcomes of commercially approved intracept™ intraosseous nerve ablation systems in the treatment of patients diagnosed with vertebrogenic pain.

the objective of this study is to compile real-world outcomes of commercially approved intracept™ intraosseous nerve ablation systems in the treatment of patients diagnosed with vertebrogenic pain.

Eligibility criteria:
inclusion criteria: * study candidate is scheduled to be treated with a commercially approved intracept™ intraosseous nerve ablation system per local instructions for use (ifu). * signed a valid, irb/ec-approved informed consent form. exclusion criteria: * meets any contraindications per locally applicable instructions for use (ifu).

Keywords: intraosseous basivertebral nerve ablation axial low back pain low back pain
efficacy of tamsulosin oral-controlled absorption system (ocas) in the treatment of distal ureteral stones

Conditions: Ureteral Calculi

Summary: this is a randomized double blind placebo-controlled study that will assess the efficacy of tamsulosin oral-controlled absorption system (ocas) 0.4 mg in the conjunctive medical treatment of distal ureteral stones with a size of 4-10 mm compared to placebo in control group.

* patient will be randomized to receive placebo or tamsulosin ocas 0.4 mg 1 tablet od for a maximum of 28 days or until the ureteral stone is passed and sodium diclofenac 50 mg twice a day, for 10 days. * all patients will receive 75 mg sodium diclofenac via intramuscular on demand

Eligibility criteria:
inclusion criteria: * male or female patient aged =\> 18 years. * patients who have distal ureteral stones with a size of 4-10 mm * written informed consent has been obtained. exclusion criteria: * patients with history of ureteral surgery * patients with urinary tract infection * patient with diabetes and peptic ulcer * patient with renal dysfunction (elevated of serum creatinine level) * patients with severe hydronephrosis * patients with history of passing stones * pregnancy * patients who desire to withdraw from the study
sta-5326 in crohn's disease patients

Conditions: Crohn's Disease

Summary: the purpose of this study is to determine the safety and tolerability of sta-5326 given once daily or twice daily to crohn's disease patients with moderate disease.


Eligibility criteria:
inclusion criteria: * patients 18-65 years old * crohn's disease for 6 months * cdai scores between 220-450 * +/- 5-asa, stable dose for \> 2 weeks * +/- corticosteroids, less than or equal to 40 mg per day with a stable dose for 2 weeks * +/- infliximab with no treatment within 4 weeks * +/- 6-mercaptopurine, with a stable dose for 8 weeks * +/- antibiotics, with a stable dose for 2 weeks exclusion criteria: * patients who have had methotrexate, cyclosporine, or other experimental drug within 3 months of screening * pregnancy, breast feeding * history of total proctocolectomy with stoma. previous ileocolectomy would not be a contraindication to the study * bowel obstruction * surgical bowel resection within 90 days * total parenteral nutrition (tpn), cya, tacrolimus

Keywords: crohn's disease
topotecan for irinotecan-refractory sclc

Conditions: Lung Cancer; Refractory to Chemotherapy

Summary: although the efficacy of topotecan as second-line chemotherapy for sclc has been consistently demonstrated in phase ii/iii clinical trials, the choice of irinotecan as first-line therapy prevented use of the evidence-based option. this pilot study will be conducted to determine the activity and safety of topotecan in sclc patients refractory to first-line therapy with irinotecan and platinum.

current commonly used second-line approaches for sclc include re-induction with first-line therapy for chemosensitive disease, or single-agent topotecan. although the efficacy of topotecan as second-line chemotherapy for sclc has been consistently demonstrated in a number of clinical studies, the choice of irinotecan as first-line therapy prevented use of the evidence-based option such as topotecan. topotecan and irinotecan are cytotoxic agents that inhibit same intracellular pathway, namely topoisomerase i, which is an enzyme involved in dna replication and rna transcription. although their mechanism of action is similar, the preclinical and clinical data of these two drugs have some notable differences. topotecan and irinotecan have different spectra of antitumor activity in various models of human cancer. clinical data support that these agents may have different spectra of activity. the differences in antitumor activities may also reflect different mechanisms of resistance. furthermore, topotecan and irinotecan have different limiting toxicities (myelosuppression and diarrhea, respectively).

Eligibility criteria:
inclusion criteria: * histologically or cytologically proven sclc * refractory to prior irinotecan-based chemotherapy * eastern cooperative oncology group (ecog) performance status ≤2 * age between 18 and 75 years * no active brain or leptomeningeal metastases * adequate hematologic, hepatic and renal functions * at least one measurable lesion(s) exclusion criteria: * pregnant or lactating women * patients with active infection * extensive radiotherapy within the previous 4 weeks * previous other malignancies with the exception of adequately treated non-melanoma skin cancer or in situ cervical cancer * any severe comorbid illness * a known history of anaphylaxis of any origin * history of severe adverse events to the drug used in this study

Keywords: small-cell lung cancer refractory topotecan
acute effects of isoenergetic hiie vs. mice on key parameters of fat mass loss in young females with overweight or obesity

Conditions: Overweight and Obese Adults; High Intensity Interval Exercise (HIIE)

Summary: overweight and obesity, particularly increased total and/or abdominal fat mass (fm), are strongly linked to the development of cardiovascular diseases. managing obesity effectively requires lifestyle and dietary modifications, including increased physical activity. among the various exercise strategies, moderate-intensity continuous training (mict) and high-intensity interval training (hiit) are widely recommended for reducing fm. compared to mict, hiit is a time-efficient approach, often perceived as more enjoyable, and has been shown to promote greater total and abdominal fat loss in a shorter period. however, the precise mechanisms underlying this enhanced fat loss remain unclear. this study aims to compare the acute effects of two isoenergetic exercise sessions - mice (moderate-intensity continuous exercise) and hiie (high-intensity interval exercise) - on key physiological responses involved in fat mass loss. specifically, we will assess plasma catecholamine levels during exercise and recovery, as well as oxygen consumption, substrate oxidation, and appetite over the 2-hour post-exercise period in young females with overweight or obesity. by elucidating the role of catecholaminergic stimulation as a potential regulator of fat mass loss, this research could provide valuable insights for optimizing exercise strategies in weight management and metabolic health.


Eligibility criteria:
inclusion criteria: * women with overwieght or obesity (bmi: 25-35 kg/m²) exclusion criteria: * contraceptive use * menopause * irregular menstrual cycle * medical contraindications to intense physical activity, * painful joints, * taking ß-blocker

Keywords: oxygen consumption high intensity interval training substrate oxydation catecholamines obesity
sdr monitoring in children with cerebral palsy

Conditions: Cerebral Palsy

Summary: the study evaluates the anatomical distribution of the assessed electromyogram (emg) responses ensuring after sensory nerve root stimulation and obtained iom grading during selective dorsal rhizotomy (sdr) with regard to level and, side of the body and gender as well as pain management and outcome data.


Eligibility criteria:
inclusion criteria: * male and female children with spastic cerebral palsy undergoing selective dorsal rhizotomy surgery including intraoperative neuromonitoring exclusion criteria: * \> 21 years
comparison of efficacy of paravertebral and epidural analgesia after videothoracoscopic lung lobectomy

Conditions: Lung Cancer

Summary: thoracic surgery correlates with significant pain in postoperative period. in order to alleviate the pain various combinations of pharmaceuticals and administration methods are employed. so as to reduce the extent of surgical trauma and, consequently, correlated pain various operation techniques are used. in traditional thoracotomy epidural anesthesia remains a golden standard. epidural anesthesia however demands high skills to be performed correctly and presents an increased risk of grave complications. in videothoracoscopic (vats) operations paravertebral blockade can be employed, yet there is no certainty if its efficacy after lung lobectomy. we therefore designed a prospective, randomized, parallel group, single site study to test the hypothesis, that continuous paravertebral blockade is as efficient in postoperative pain reduction as continuous epidural blockade and possesses a higher safety profile.


Eligibility criteria:
inclusion criteria: 1. american society of anesthesiologists (asa) physical status 1-3 2. undergo videothoracoscopic lung lobectomy 3. forced expiratory volume in 1 second (fev1) \>1,5 l/min 4. no contraindications for epidural anesthesia and paravertebral nerve blockade 5. ability to comprehend principles of vas pain examination method and to communicate in accordance with them. exclusion criteria: 1. prior to the study: contraindications for local anesthesia, asa\>3, fev1\<1,5 l/min, conditions disabling the patient from comprehending the principles of vas pain examination, known allergy to used medications. 2. during the study: failure to place epidural or paravertebral catheter, decision to abandon lobar resection (e.g. in case of neoplastic dissemination), intraoperative conversion to thoracotomy, intraoperative anatomical obstacles to distribution of local anesthetics, conditions disabling the patient from pain evaluation by means of vas method (e.g. postoperative delirium), necessity to administer other pharmaceuticals influencing pain perception (e.g. sedatives), necessity of mechanical ventilation, interruption of local anesthesia as a result of technical problems (e.g. damage or slippage of catheter).

Keywords: paravertebral block thoracic epidural analgesia videothoracoscopic surgery lung lobectomy
suprapatellar nailing of tibial shaft fractures

Conditions: Broken Leg

Summary: to investigate the functional outcomes and prevalence and severity of knee pain for patients undergoing suprapatellar nailing of tibial shaft fractures.

suprapatellar nailing... participants will be followed for 10 years prospectively. follow up visits will occur at 2 weeks, 6weeks, 3 months, 6 months, 12 months, 3 years, 5 years, 7 years and 10 years. interim analysis will be done at 1, 3, 5, and 7 years with final analysis occuring at 10 years. primary and secondary endpoints in patients undergoing suprapatellar nailing of tibial shaft fractures are: 1. to evaluate the long term presence of knee pain 2. to evaluate the long term functional outcomes

Eligibility criteria:
inclusion criteria: * isolated, unilateral tibial shaft fractures * orthopaedic trauma association (ota) classification of 42 and may extend to 43a or 43b * age 18-65, including pregnant women * open or closed fractures * able to sign consent * english speaking exclusion criteria: * compartment syndrome * other lower extremity injuries that will affect functional outcomes * problems maintaining follow up (homeless, not willing to return for follow up) * pathological fractures * prisoners * previous retained hardware in the injured leg * injuries requiring vascular repair

Keywords: tibial shaft fractures
using caring contacts to reduce psychiatric morbidity following hospitalization during the covid-19 pandemic

Conditions: Psychiatric Hospitalization

Summary: subjects will be recently discharged patients from sunnybrook inpatient psychiatry unit. subjects will be randomized in a 1:1 ratio to either the caring contact intervention or usual care. 75 subjects will be enrolled in each arm. in additional to usual discharge-related care, subjects in the caring contact group will receive brief emails that convey a message of hope and provide resources. these emails will be sent on days 4, 21, and 56 post-discharge. the specific content of these emails will be pre-determined varying slightly by time point. in contrast, the control group will only receive usual discharge-related care, including discharge planning and also a sheet of resources normally provided to patients. a widely used and validated measure will be employed to assess depression and anxiety symptoms. the 25-item self-report hopkins symptom checklist will be emailed to all subjects at baseline, day 4, 21, and 56 post-discharge, along with the caring contact communication. it is hypothesized that there will be a significantly greater reduction in mental health symptoms among patients receiving caring contacts compared to those who receive usual care.


Eligibility criteria:
inclusion criteria: * provision of written informed consent * inpatient status in sunnybrook inpatient psychiatry unit at time of recruitment * have an email or mailing address * ability to read and understand english * the ability to understand and comply with the requirements of the study and capable of providing informed consent exclusion criteria: * a primary major neurocognitive disorder diagnosis

Keywords: caring contacts suicide prevention
effect of acute and sub-acute administration of gluten on extra-intestinal and gastrointestinal symptoms in healthy subjects

Conditions: Healthy Volunteers, Gluten

Summary: the investigators will investigate the effects of acute and sub-acute administration of gluten on mood, intestinal permeability, gastrointestinal symptoms and gut peptide levels in healthy volunteers (hv).


Eligibility criteria:
inclusion criteria: * body mass index (bmi) of 20 - 25 kg/m2 * stable body weight for at least 3 months prior to the start of the study exclusion criteria: * medical * coeliac disease (excluded either by absence of the hla-dq2 and hla-dq8 haplotype or by a normal duodenal biopsy (marsh 0) performed at endoscopy while on a gluten containing diet in individuals expressing the hla-dq2 (human leukocyte antigen) or hla-dq8 haplotype) * abdominal or thoracic surgery. exception: appendectomy * gastrointestinal, endocrine or neurological diseases * cardiovascular, respiratory, renal or urinary diseases * hypertension * diagnosed food or drug allergies * psychiatric disorders * eating disorders * depressive disorders * anxiety disorders * psychotic disorders * restraint or emotional eating * dieters, especially no gluten-free diet or a diet low on gluten * medication on a regular basis, exception: oral contraception * smoking * history of cannabis use or any other drug of abuse for at least 12 months prior to the study * alcohol abuse (more than 21 units of alcohol for men, more than 14 units for woman per week) * pregnant or breastfeeding women