Kornimate/medical-research-clean huggingface dataset:
scmc trial on khe with kmp (v.2020)

Conditions: Kaposiform Hemangioendothelioma (KHE) With Kasabach-Merritt Phenomenon (KMP)

Summary: a phase i trial focusing on safety and efficacy of prednison shock plus sirolimus maintenance in treating kaposiform hemangioendothelioma (khe) with kasabach-merritt phenomenon (kmp)


Eligibility criteria:
inclusion criteria: * kaposiform hemangioendotheliomas with kasabach-merritt phenomenon * 0 - 12 years of age at the time of study entry * male or female * consent of parents (or the person having parental authority in families) * signed and dated written informed consent exclusion criteria: * with hematological diseases * with other solid tumors * with hypertension, diabetes, adrenal insufficiency, neurological diseases, liver and kidney * dysfunction, and cardiopulmonary insufficiency * with tuberculosis,cytomegalovirus and epstein-barr virus infection before the treatment
the effect of liposuction on menses: a retrospective study

Conditions: Menstrual Irregularity

Summary: the prevalence of obesity nearly tripled from 1975 to 2021, resulting in liposuction, as an effective shaping method, to be performed more frequently. liposuction is a surgical procedure that uses a specialized instrument to suck fat fragments in the subcutaneous fat layer through a small incision. analyzing a large sample sizes of patients who had liposuction, we found that some female patients underwent menstrual irregularity after liposuction. in 2004, carolyn et al. reported several cases in which there was a connection between liposuction and an early onset of menses. further studies showed that an early onset of menses may be related to the volume of adipose tissue extracted, the amount of anesthesia given, the area of liposuction, and body weight. however, the sample of that study was small, as there were only 17 cases included in the statistical model, and there are few articles in which the impact of liposuction on menses has been studied. to better understand whether menstrual irregularity will occur after liposuction, patients with postmenopausal or preoperative menstrual irregularity were excluded, leaving a sample of 518 female patients to be reviewed. a better understanding of the impact of liposuction on menses may help clinical doctors predict the underlying risk of menstrual irregularity after liposuction and identify individuals at higher risk. the findings may contribute to further understanding of menstrual irregularity.


Eligibility criteria:
inclusion criteria:patients who were in 18-55 and have a regular menses - exclusion criteria:patients who were younger than 18 years old or older than 55 years old, who were in the perimenopausal or postmenopausal stage or who had menstrual irregularity before plastic surgery were excluded from both groups. -
lifestyles and breast cancer

Conditions: Malignant Tumor of Breast

Summary: background: in spain, 1 out of every 11 women will have a breast cancer before the age of 85 years and breast cancer is the leading cause of potential years of life lost. the randomized intervention in predimed trail, using mediterranean diet with free provision of extra virgin olive oil (meddiet+evoo) dramatically and significantly reduced the occurrence of cases of postmenopausal breast cancer. objectives: assess the efficacy of a nutritional intervention with meddiet+evoo for the prevention of relapses among women with early breast cancer. methods: randomized, multicenter trial (lifebreast) among 766 women diagnosed with early breast cancer. participants will be randomized in a 1:1 ratio to i) meddiet+evoo or ii) low-fat diet. changes in circulating tumor cells, inflammatory biomarkers, oxidative stress and quality of life will be evaluated. the intervention will be delivered by face-to-face interviews with study dietitian, phone calls, and online tools. participants in the meddiet+evoo group will receive 0.5l/week of evoo and participants in the low-fat group will receive allotments of different foods, both at no cost. generalized estimating equations will be used to estimate between-group differences in the following outcomes: circulating tumor cells, inflammatory biomarkers, oxidative stress, and quality of life will be evaluated.


Eligibility criteria:
inclusion criteria: women with primary pathologically confirmed invasive breast adenocarcinoma in stages i, ii or iiia exclusion criteria: * breast cancer recurrence * in situ cdis or ldis * inability or unwillingness to give written informed consent * difficulty to comply with the intervention * lack of willpower to change their diet (using the models of prochaska and diclemente) * inability or unwillingness to communicate with study personnel * medical condition that prevents the intervention (digestive disease with fat intolerance; severe psychiatric, neurological or endocrine disease; or allergy or hypersensitivity to any of the key foods of the intervention (evoo or nuts) or impossibility to follow a mediterranean diet and/or evoo intake * immunodeficiency or hiv-positive status * concomitant condition that limits life-expectancy to less than 1 year * difficulty or impossibility for an adequate follow-up * institutionalized patients with lack of autonomy * impossibility for attending group sessions and yearly follow-up visits or for telephone contact * usual alcohol consumption \>80 g/d * bmi\>40 * patients with acute infection or inflammatory process (e.g. pneumonia) may be included in the study three months after the resolution of the infectious symptoms

Keywords: breast cancer prognosis mediterranean diet extra-virgin olive oil low-fat diet
the effect of wbpc on subacute stroke patients

Conditions: Stroke

Summary: whole body periodic acceleration (wbpa) is a head-to-toe movement. the function wbpa works as adding pulses to the circulation. this motion increases shear stress to the endothelium, which stimulates increased release of endothelial-derived nitric oxide (eno), prostaglandin e-2, tissue plasminogen activator (tpa) into the circulation, and these substances are cardioprotective and contribute to vasodilatation. the wbpa were not well studied than whole body vibration (wbv), a vertical rocking training machine, and most researches focused on cardioprotective effects. a study revealed the effect of moderate-intensity exercise and whole-body periodic acceleration on nitric oxide release was the same. this instrument is quite safe and was applied to patients with varied diseases in previous study. no sound contraindication was mentioned till now. our hypothesis is assuming that the circulation of brain could improve after the intervention of wbpa, and stroke recovery and cadio-pulmonary function will improve subsequently.

so the investigators will recruit subacute stroke patients as our subjects. the patient who is booked to our rehabilitation ward for further rehabilitation programs is eligible for our study. the investigators will recruit 30 patients, and randomize them to experimental and control group. this study is going to be single blinded, which the evaluator is blinded to the condition of the subjects. whether experimental or control groups will received the same intensive rehabilitation programs (6 days a week). the experimental group will receive additional wbpa treatment. the duration will be 30 minutes a time, and the frequency will be 5 days a week, and the treating period will be 3 weeks. the evaluator will assess twice, before and after the experiment period. the measurements include: muscle power, brunnstrom stages, barthel index, functional independence measure (fim), time up and go test, 6 minutes walk test, fugl-meyer assessment, berg balance scale, cardio-pulmonary test. in addition, to confirm the immediate effect of wbpa over brain circulation, the investigators will choose 6 patients to received carotid ultrasonography before and immediately after the wbpa treatment.

Eligibility criteria:
inclusion criteria: * subacute stroke patient onset 1-3 months, age from 40-80 years-old exclusion criteria: * cognition impaired(mmse\ 12
accuracy of cough detection in healthy adults

Conditions: Cough

Summary: cough is part of the defense mechanism to protect the lung from foreign particles and remove secretions from the airways. however, at times it becomes a bothersome, annoying symptom that interferes with the quality of life, sleep pattern and exercise tolerance of the patient. people with respiratory infection, asthmatic patients and cf patients suffer from a multitude of pathologies of airways and are often inflicted with chronic cough. treatment of cough in these patients consists of many types of expectorants, cough suppressors, secretion modifiers, inhaled bronchodilators etc. in addition, chest physical therapy (pt) is often prescribed as part of the treatment regime. the primary objective of the study is to evaluate the efficacy and validity of novel cough counting device based on the wim technology.


Eligibility criteria:
inclusion criteria: * patient signed informed consent * patients above 21 years old * no medical history exclusion criteria: * skin lesions precluding attachment of sensors * pregnancy

Keywords: cough wheeze rate respiratory function tests
task-state-based temporal interference stimulation (ti) to improve depression in patients with bipolar disorder

Conditions: Bipolar Depression

Summary: the purpose of this study is to investigate the efficacy and safety of temporal interference stimulation (ti) in improving depressive episodes of bipolar disorder, to analyze the therapeutic principle of ti in bipolar disorder depressive episodes based on task state mri scanning, and to explore the abnormal regulation mechanism of anhedonia neural circuit.


Eligibility criteria:
inclusion criteria: 1. aged 16-50 years, right-handed, and completed nine years of compulsory education; 2. meet the diagnostic criteria for bipolar disorder in the diagnostic and statistical manual of mental disorders, fifth edition (dsm-5); 3. hamd-17: \>17 points , assessed the presence of rapture deficits; 4. subject had not been treated with a mood stabilizer, or had previously used an antidepressants and currently off medication for ≥1 week; 5. the subject/legal guardian is willing to actively cooperate with the treatment and sign an informed consent form after being fully informed of the temporal interference stimulus (ti). exclusion criteria: 1. co-morbid other psychiatric disorders, including affective psychiatric disorders, anxiety spectrum disorders, mental retardation, substance dependence (abuse), etc.; 2. history of a serious physical illness or a disease that may affect the central nervous system; 3. neurologic disorders or risk of seizures such as previous cranial disorders, head trauma, abnormal electroencephalograms, magnetic resonance evidence of structural brain abnormalities, or a family history of epilepsy; 4. contraindications to magnetic resonance scanning or time-interference stimulation (ti), such as the presence of metallic or electronic devices in the body (intracranial metallic foreign bodies, cochlear implants, pacemakers and stents, and other metallic foreign bodies); 5. those who have received or are receiving electroconvulsive therapy (ect ), modified electroconvulsive therapy (mect ), transcranial magnetic stimulation (tms), transcranial direct current stimulation (tdcs), transcranial alternating current stimulation (tacs), or other neurostimulation treatments; 6. pregnant and lactating women, and women of childbearing age with positive urine pregnancy.
pdl1 in ovarian high grade serous carcinoma

Conditions: Ovarian Cancer

Summary: the main purpose is to study the prognostic effect of pdl1 in ovarian cancer especially hgsc. therefore, in the present study the investigators analyzed the expression of pdl1in hgsc by immunohistochemistry, and results were correlated to prognosis.

this cross-sectional study on 54 specimens of primary ovarian high grade serous carcinoma cases who attended to oncology centre, mansoura university, mansoura, egypt in the period from 2012 till 2019. the cases were chosen randomly. all clinicopathological data including tumor stage (t), l.n metastases (n), metastasis (m), (figo) staging system, ascites, recurrence, residual tumor, cea level, ca125 level, and peritoneal deposits analyzed. the investigator followed the clinical outcomes in the form of disease free survival (dfs) and overall survival (os). the mean duration of follow up will be 43.4 months. the os were calculated from the time of diagnosis to death. dfs is the time from the end of therapy to first recurrence or metastases. the specimens were stained with pdl1 marker in pathology department port said university. statistical analysis: data was analyzed using spss software v.16. continuous data was presented in the form of mean (sd) or median (min-max) according to the results of shapiro-wilk testing for the assumptions of normal distributions of data. categorical data will be presented in the form of frequencies and percentages. statistical significance will be tested by welch's t-test, or mann-whitney u for continuous data (with respect to presence or absence of normal distribution of data). also, chi square test or fisher's exact test will be performed for categorical data (with respect to the minimal expected values in the contingencies tables). correlations of different tumour markers will be calculated using spearman's rho coefficient. kaplan-meier test was used to test for overall survival and disease free survival of patients with respect to tumour expression of pdl1. comparisons will be done using log rank (mantel-cox). significance level is set at 0.05.

Eligibility criteria:
inclusion criteria: * patients diagnosed with primary ovarian cancer exclusion criteria: * patients with metastatic ovarian cancer
study of imdusiran (ab-729) in combination with intermittent dosing of durvalumab in subjects with chronic hbv infection

Conditions: Hepatitis B, Chronic

Summary: this is a phase 2a, open-label, multicenter study investigating the safety, tolerability, and antiviral activity of durvalumab administered at targeted times during a 48-week treatment period of imdusiran in virologically-suppressed chb subjects


Eligibility criteria:
key inclusion criteria: * male or female between the ages of 18-65 * willing and able to provide informed consent * willing to follow protocol-specified contraception requirement key exclusion criteria: * have extensive fibrosis or cirrhosis of the liver * have or had liver cancer (hepatocellular carcinoma) * family history or personal history/current thyroid disease on or off replacement therapy * have a history or current autoimmune disease or has been on immunosuppressive medications within 6 months of the start of the study * females who are breastfeeding, pregnant or who wish to become pregnant during the study * known chronic or severe infection or recent significant exposure to infections such as tuberculosis or endemic mycosis, untreated latent infections like tuberculosis, or a positive or indeterminate quantiferon test. note: other protocol defined inclusion/exclusion criteria may apply.
slnm in endometrial cancer combined with osna

Conditions: Endometrial Cancer

Summary: the aim of the study is to compare one-step nucleic acid amplification method (osna) with histological ultrastaging examination in the sentinel lymph node assessment in patients with endometrial cancer. the molecular biologic method osna is a modern way of metastatic spread detection in lymphatic nodes using quantitative reverse transcription polymerase chain reaction. cytokeratin 19 (ck 19) was selected based on previous studies as the optimal mrna marker (detected by osna). the intraoperative identification and rapid assessment of sentinel lymph nodes by osna could help to improve the standards of care in endometrial cancer patients.

method: after the sentinel lymph node detection (icg, 99m tc or bleu patente) and sentinel node/nodes removal is performed, the node/nodes is/are cut in 2-mm slices parallel to short axis of the node. the odd-numbered blocks will be examined by the osna method and the even-numbered blocks will be examined by conventional histopathological methods including immunohistochemistry. statistical analysis to identify differences will be performed subsequently.

Eligibility criteria:
inclusion criteria: * endometrial cancer * signed informed consent exclusion criteria: * inclusion criteria not met * pregnant patients * patients participating in other clinical studies * patients who have been judged to be an inappropriate candidate by any medical care provider

Keywords: osna sentinel lymph node endometrial cancer
a sample collection study to validate the nephroclear™ ccl14 test

Conditions: Acute Kidney Injury

Summary: the objective of this sample collection study is to collect urine samples to validate the nephroclear™ ccl14 test in patients with kdigo stage 2 or 3 aki. this study is observational and will have no impact on the medical management of the subject.


Eligibility criteria:
inclusion criteria: 1. males and females 21 years of age or older; 2. receiving care in an intensive care unit; 3. expected to remain in the icu for at least 48 hours after enrollment; 4. use of indwelling urinary catheter as standard care at the time of enrollment; 5. subject must have acute kidney injury (kdigo stage 2 or stage 3) at the time of sample collection; 6. urine sample must be collected within 36 hours of meeting kdigo stage 2 criteria; 7. written informed consent provided by patient or legally authorized representative (lar). exclusion criteria: 1. prior kidney transplantation; 2. comfort-measures-only status; 3. already receiving dialysis (either acute or chronic) or in imminent need of dialysis at the time of enrollment; 4. known infection with human immunodeficiency virus (hiv) or active hepatitis (acute or chronic); 5. special populations, pregnant women, prisoners or institutionalized individuals.
idiopathic toe-walking position sensation

Conditions: Gait Disorder, Sensorimotor

Summary: the aim of this study is to investigate the effect of plantar two-point discrimination on hip-knee-ankle position sense in children with toe walking.the main questions it aims to answer are: * are two-point discrimination and light pressure sensation in the plantar region affected in children with idiopathic toe gait? * does the two-point discrimination in the plantar in general and the heel in particular affect the position sense of the hip-knee and ankle?

children who tend to walk on toes after they should have developed a heel-toe gait are diagnosed with idiopathic toe walking (itw).cerebral palsy, muscular dystrophy, and orthopaedic problems such congenital talipes equinus are some of the diseases that are frequently linked to a toe-walking gait. a diagnosis of itw is made when there is no physical or medical cause for the absence of a heel strike. five percent of healthy children are estimated to have itw, and boys are more likely than girls to be affected. reduced ankle range of motion is prevalent symptom in children with itw. since itw often manifests as symmetrical tiptoe walking in children, reports showing a comparable bilateral reduction in ankle range of motion at both lower limbs indicate the symmetrical character of this gait type. lower vibration perception thresholds, a tendency to be left-handed, and noticeable variations in sensory seeking and modulation scores are all characteristics of children with an itw gait. the small fibers that innervate the cutaneous receptors (such as merkel's cell, pacinian corpuscles, meissner's corpuscles, and ruffini endings in the skin) are more crucial for postural control than the large fibers that innervate the major muscle spindles and the golgi tendon organs. standing balance control is more dependent on merkel's cells and ruffini endings (slow adapting receptors), which are in charge of touch and pressure sensitivity, than it is on meissner's and pacinian corpuscles (rapid adapting receptors), which are in charge of vibrotactile sensitivity.additionally, it has been demonstrated that tactile sensation in the foot sole affects the activity of the tibialis anterior muscle as well as the regulation of gait pattern at lower limb joints. these investigations support the notion that cutaneous feeling is crucial for preserving postural and gait stability.the literature states that plantar pressure and sensory changes have disruptive effects on postural control.the aim of this study is to investigate the effect of plantar two-point discrimination on hip-knee-ankle position sense in children with toe walking.

Eligibility criteria:
inclusion criteria: * having idiopathic toe walking diagnosis exclusion criteria: * having another known neuromuscular disease

Keywords: idiopathic toe walking
progesterone & postpartum relapse to smoking

Conditions: Tobacco Use Cessation; Tobacco Use Disorder

Summary: the primary goal of this project is to investigate the potential efficacy of exogenous progesterone (with supplemental relapse prevention counseling) on postpartum relapse in new mothers. also to determine the feasibility of enhanced compliance monitoring and identification of collateral factors effecting outcomes.

pregnant women will be recruited at gestational weeks 33-36 who have quit smoking during pregnancy and are motivated to maintain abstinence after delivery. at the time of delivery, women will be randomly assigned to receive 4 weeks of active or placebo exogenous progesterone starting on the 4th day postpartum. participants will be in contact with study staff either by phone or clinic visits until 12 weeks postpartum to collect data on smoking status and protocol compliance, measure serum progesterone levels and receive behavioral counseling.

Eligibility criteria:
inclusion criteria: * woman * 18-35 years old * zero cpd for past 4 weeks * 5 or more cpd for at least 6 out of past 12 months * motivated to remain abstinent (7 or higher out of 10) * stable physical/mental health * established prenatal care * stable physical/mental health * willing to take progesterone * willing to use double-barrier protection if sexually active * english fluency * able to provide informed consent exclusion criteria: * psychotropic medications * illicit drugs * other types of tobacco, nrt, smoking cessation medications * pregnancy complications (diabetes, anomaly, fetal growth restriction, htn, hx of \>2 miscarriages) * current use of: finasteroid (propecia), efavirenz, red clover, ketoconazole, cyp3a4 inhibitors * history of: thrombophelitis, deep vein thrombosis, pulmonary embolus, clotting disorder, bleeding disorder, heart disease, diabetes, stroke, peanut allergy, liver dysfunction, hypersensitivity to progesterone

Keywords: pregnant smoker cigarette tobacco