Kornimate/medical-research-clean huggingface dataset:
surgical outcome of two-port laparoscopic myomectomy

Conditions: Uterine Myoma

Summary: study objective: to evaluate the surgical outcome of laparoendoscopic two-sites myomectomy (lets-m) and compare the difference between an experienced surgeon and three trainees. design: a retrospective study. setting: a university hospital and a tertiary care center. patients: 204 women underwent lets-m

laparoscopic myomectomy (lm) is an alternative and advanced technique that can take the place of traditional open surgery and achieve the goal of minimally invasive operation for women who wish to preserve the uterus. however, lm is considered a time-consuming procedure, requiring more suturing and knot-tying, and is better performed for woman with an appropriate uterine size by experienced surgeons. laparoendoscopic two-sites myomectomy (lets-m) is a novel setting for lm on a two-port basis, using the umbilical glove port, three trocars, and conventional laparoscopic equipment. between january 2015 and september 2019, the medical records of women with uterine myoma managed by lets-m were retrospectively reviewed. the review of the chart records consisted of a detailed history, such as age, body mass index (bmi), gravidity, parity, marital status, sexual experience, previous abdominal surgery, and hospital stay after the surgery. all women received preoperative ultrasound for their uterine myoma assessment, including the location, type, size, number, and accompanying pathology, such as an ovarian tumor. the myoma locations were identified during the operation and classified into fundal wall myoma, anterior wall myoma, posterior wall myoma, and cervical myoma. the myoma type classification was based on the international federation of gynecology and obstetrics (figo) leiomyoma subclassification system. we measured the weight of the specimen after finishing the surgery. the operation time was defined as the period from the incision to the closure of the skin. any intraoperative blood loss less than 50ml or minimal blood loss on operation note was recorded as 50 milliliters in this study. excessive blood loss was defined as more or equal to 500 milliliters in the operation. the postoperative pain scale was evaluated by a visual analog scale (vas) on the first and second postoperative days.

Eligibility criteria:
inclusion criteria: * women older than 20 years old and had not reached menopause * symptomatic uterine myomas, such as hypermenorrhea, infertility, a mass effect-related urinary frequency, and constipation. exclusion criteria: * dominant symptoms with active pelvic or urinary tract infection * a history of pelvic radiotherapy * a preexisting or suspicious malignant pelvic tumor * pathologies other than uterine myoma noted during the operation

Keywords: laparoscopy two-port
evaluation of sphingolipids as predictive biomarkers of immune checkpoint inhibitor response in melanoma patients

Conditions: Melanoma

Summary: this trial is a translational proof-of-concept, open-label, prospective cohort study of 60 patients aiming to identify the clinical markers and/or biomarkers associated with therapeutic response to immune checkpoints inhibitors, in patients with advanced melanoma. the study will be conducted on a population of patients treated with anti-pd-1 alone (nivolumab or pembrolizumab) or in combination (nivolumab + ipilimumab) in the context of routine care. for each included patient, blood samples will be collected at different time points. if feasible, an optional tumor biopsy specimen will be collected during baseline visit. all included patients will be followed-up for tumor response and toxicity until week 12. after week 12, survival data (tumor status and/or survival status) will be collected every 3 months until a maximum duration of 1 year from the first study dose.


Eligibility criteria:
inclusion criteria: 1. age ≥18 years at the time of study entry. 2. patient with histologically-proven metastatic and/or unresectable melanoma (stage iiic-iv, m1a-c as per ajcc 8th edition), including mucosal melanoma, without intracranial active disease. 3. patient for which a treatment with immune checkpoint inhibitor (nivolumab alone, pembrolizumab alone, nivolumab plus ipilimumab) has been decided. 4. subjects are included regardless of brafv600 mutation status. brafv600 mutation status must be documented. 5. patient must be naïve to immune checkpoint inhibitor treatment for locally advanced and/or metastatic disease (i.e., no prior treatment with ici and current treatment with ici not yet started). 6. ecog performance status 0-2. 7. life expectancy of at least 3 months. 8. patient able to participate and willing to give informed consent prior performance of any study-related procedures and to comply with the study protocol. 9. patient affiliated to a social health insurance in france. exclusion criteria: 1. patient pregnant, or breast-feeding. 2. uveal melanoma. 3. any condition contraindicated with sampling procedures required by the protocol. 4. any psychological, familial, geographic or social situation, according to the judgment of investigator, potentially preventing the provision of informed consent or compliance to study procedure. 5. any current severe or uncontrolled disease, including, but not limited to ongoing or active infection. 6. patient who has forfeited his/her freedom by administrative or legal award or who is under guardianship.

Keywords: melanoma sphingolipids immune checkpoints tumor-infiltrating lymphocytes immunosuppressive cytokines circulating leukocytes
transcutaneous submandibular gland biopsy: feasibility of repeat biopsy as a progression marker for parkinson's disease

Conditions: Parkinson Disease

Summary: the purpose of this study is to perform biopsies of one of the glands that make saliva. the biopsied tissue will then be analyzed to see if it has changes that occur in parkinson's disease. this study will determine whether it is possible to do a second biopsy a few years after a previous biopsy and determine whether there are changes in the biopsy that would allow for analysis of disease progression.

tissue biopsies documenting the presence and density of lewy type synucleinopathy (lts) in living patients with probable parkinsons disease (pd) would be extremely valuable as a diagnostic test, as a marker of molecular therapeutic target engagement and as a progression marker. based on recent data from our group with both early and advanced pd patients, we propose to perform a second transcutaneous submandibular gland (smg) needle core biopsy in 12 patients who have previously been biopsied and had lts present in their smg tissue.

Eligibility criteria:
inclusion criteria 1. pd patients ages up to age 85. 2. previous participation in a smg biopsy study at mayo clinic arizona with a positive biopsy being reported exclusion criteria 1. evidence for dementia that would preclude the patient from signing informed consent 2. history of bleeding diathesis or hematologic disorders 3. medically unable to undergo a core needle biopsy of the submandibular gland 4. prior treatment of the submandibular gland with botulinum toxin injections. 5. history of past or current acute infection or abscess of the submandibular gland. 6. history of past or current neoplastic process within the submandibular gland. 7. history of peripheral neuropathy.
transdermal fentanyl and melatonin patches for postoperative pain relief

Conditions: Postoperative Pain

Summary: seventy five patients, aged 18-50 years, asa i and ii undergoing elective single level lumber laminectomy under general anesthesia were included in this randomized controlled double-blind study. patients were randomly divided into 3 groups 25 each, c group patients received transdermal placebo patch, tdf group (50μg/h) and tdm group (7 mg). assessment of postoperative pain, sedation, hemodynamic variables such as hr and map, postoperative monitoring of arterial spo2 and side effects (e.g. nausea, vomiting, pruritis, respiratory depression and hemodynamic instability) were done 30 minutes, 1, 2, 6 and 12 hours postoperatively. postoperative patient's and surgeons' satisfaction, intraoperative bleeding and plasma cortisol (µg / dl) postoperatively were also assessed.


Eligibility criteria:
inclusion criteria: * 75 patients aged between 18 and 50 years old * both sex of asa physical status i and ii * 70-90 kg body weight * height 160-180 cm * undergoing elective single level lumber laminectomy under general anesthesia. exclusion criteria: * patients with impaired kidney or liver functions * history of cardiac or central nervous system disease * history of drug or alcohol abuse * history of chronic pain or daily intake of analgesics * uncontrolled medical disease (diabetes mellitus and hypertension) * history of intake of non-steroidal anti-inflammatory drugs or opioids within 24 h before surgery or allergy to the used medications * coagulation defect * local infection at the site of application of transdermal patch * patient refusal or duration of surgery more than 120 minutes were excluded from the study.

Keywords: transdermal fentanyl transdermal melatonin postoperative pain lumber laminectomy relief
shilla growth permitting spinal instrumentation system for treatment of scoliosis in the immature spine

Conditions: Scoliosis

Summary: the objective of this study is to retrospectively and prospectively review patients who have undergone this technique looking at age of the patient, magnitude of the curve preoperatively, postoperatively and over time, diagnosis, pulmonary function, surgical procedures, complications, and spinal growth. the hypothesis is that shilla growth permitting spinal instrumentation coupled with a surgical technique of aggressive correction of the apex of the scoliotic curve wil allow for natural growth of the spine in a guided fashion with a limited number of future surgeries required.

traditional "growing rod" constructs of spinal instrumentation to treat severe scoliosis in young children require a return to the operating room every six to nine months until skeletal maturity. the shilla system allows for more spinal growth with fewer surgical procedures necessary for lengthenings. this is a major advantage over existing growth permitting systems and allows surgery to be performed at younger ages with better deformity correction without concerns of repeated surgeries.

Eligibility criteria:
inclusion criteria: * between the ages of 1 yr and 10 yrs * have severe, progressive scoliosis unresponsive to bracing * have severe, progressive scoliosis who cannot tolerate bracing exclusion criteria: * none

Keywords: scoliosis, immature spine
duodenal switch with a standard versus long alimentary limb

Conditions: Obesity, Morbid; Bariatric Surgery Candidate; Metabolism Disorder

Summary: the aim of this study was to determine if biliopancreatic diversion with duodenal switch (bpd-ds) with a longer strict alimentary limb at the expense of a shorter biliopancreatic limb will offer significant weight lost, but with lesser gastrointestinal complaints, protein deficiency, vitamin and trace element deficit compared to standard bpd-ds.

this two-group, randomized, single-blind pilot study is conducted in a university-affiliated tertiary care center. the study protocol was approved by our ethic committee. enrollment and randomization of the patients occurred between may 20163 and june 2015. patients are undergoing follow-up evaluation. patients were initially referred to our center for a bariatric surgery evaluation. eligible patients were 18 years of age or older and met the criteria for a laparoscopic biliopancreatic diversion. patients were excluded if they had a bmi ≥ 50 mg/m², a pacemaker, cirrhosis or if they were planing pregnancy in the next 2 years. each patient was required to provide written informed consent. patients were randomly assigned in a 1:1 ratio to undergo a standard biliopancreatic diversion (control group) or a modified biliopancreatic diversion with a longer strict alimentary limb (study group). a sealed envelope with the assignation was given to the surgeon in the operation room just before the procedure. patients are followed every 6 months after surgery, up to 24-months for clinical evaluation, resolution of comorbidities, evaluation of side-effects, quality of life, bioimpedance testing and bloodwork.

Eligibility criteria:
inclusion criteria: * candidates for a biliopancreatic diversion, bmi above 35 with comorbidities or above 40 without comorbidities exclusion criteria: * bmi ≥ 50 mg/m², pacemaker, cirrhosis or planning pregnancy in the next 2 years, hypoalbuminemia, irritable bowel syndrome.
anodal transcranial direct current stimulation on strength in subacute stroke

Conditions: Stroke

Summary: loss of strength is a common complication post stroke which leads to loss of balance and walking ability. variety of interventions are adopted to improve muscle strength after stroke. these include progressive resistance training, specific task training or functional training, functional electrical stimulation and high intensity aerobic exercises

transcranial direct current stimulation (tdcs) is a relatively new treatment approach for stroke recovery. tdcs is a neuromodulation method which involves application of weak direct current stimulations over the scalp via electrodes. it could induce plasticity via modulation of resting membrane potential and modification of spontaneous discharge rate. tdcs has been shown to have beneficial effects on mobility, muscle strength, motor learning, lower limb function, balance, gait, functionality and walking ability in post stroke patients. tdcs appears to be a promising intervention for stroke patients however its effects are not significant if used in isolation. thus, it should be used as an adjunct to some other treatment. review of available literature indicates tdcs can be a good option in short and intermediate run but its effects in the long run have not been studied yet. furthermore, to the best of my knowledge there is little literature available about the long-term effects of tdcs on muscle strength in subacute stage. therefore, this study is designed to test the long-term effects of tdcs stimulation on subacute stroke patients.

Eligibility criteria:
inclusion criteria: * subacute and first mca stroke * ischemic stroke * medium to high fall risk on bbs (bbs score ≤ 40) exclusion criteria: * hearing and visual loss/deficit * recurrent cva * neurological condition affecting balance like multiple sclerosis, parkinson disease etc * wound at skull * presence of shunt and/or metallic implant at cranial region * brain tumors * musculoskeletal conditions affecting lower limbs * cognitively compromised

Keywords: strength balance
the combination of psma-pet/mr and p2psa in early diagnosis of prostate cancer

Conditions: Prostate Cancer; PSMA; p2PSA

Summary: this is a single center prospective non-randomized controlled study. the goal of this clinical trial is to figure out whether the combination of psma-pet/mr and phi could add values to each method alone. the main questions it aims to answer are: * compare the diagnostic value of the combination with each alone and set up a diagnostic model. * compare the diagnostic value of psma-pet/mr+phi to mpmri+phi. * evaluate the diagnostic value the combination of phi and psma-pet/mr in suspected pca patients. patients will experience mpmri or psma-pet/mr and their blood samples will be used to test psa and p2psa. prostate biopsy will be the golden standard.


Eligibility criteria:
inclusion criteria: 1. preoperative clinical judgment of suspected early prostate cancer (according to nccn guidelines): meet psa ≤ 20ng/ml and clinical stage\<t3, while meeting one of the following criteria: ① digital rectal examination revealed suspicious nodules of the prostate; ② transrectal prostate ultrasound or mri found suspicious lesions; ③ psa\>10 ng/ml； ④ psa 4\~10ng/ml, f/t psa suspicious or psad value suspicious; 2. aged between 18 and 85 years; 3. generally in good health, able to tolerate and cooperate with research interventions, such as prostate biopsy and radical prostatectomy etc; 4. provide a signed and dated informed consent form; 5. commit to complying with research procedures and cooperate in the implementation of the entire process of research. exclusion criteria: 1. preoperative clinical characteristics of suspected high-risk prostate cancer (according to nccn guidelines): meet psa\>20 ng/ml or clinical stage ≥ t3; 2. have received any treatment (endocrine therapy, radiotherapy, chemotherapy, prostate resection, etc.) 3. have had prostatitis (infectious or non infectious) 3 months before the examination 4. taking 5a reductase inhibitors 5. previously diagnosed with prostate cancer 6. in the acute infection period and fever period; 7. have a hypertensive crisis; 8. in the period of decompensation due to cardiac insufficiency; 9. diseases with a tendency to severe bleeding; 10. in diabetes, blood sugar is unstable; 11. have severe internal and external hemorrhoids, perianal or rectal lesions; 12. combined with other systemic malignant tumors; 13. implantation of functional electronic devices and various stimulators such as cardiac pacemakers, cochlear implants, and cardiac stents in vivo, with implants made of ferromagnetic materials (such as iron, cobalt, nickel, etc.); 14. a perfusion device implanted in the body, such as insulin or other perfusion pumps; 15. have a history of surgery within the past 3 months, especially organ transplantation, heart and kidney surgery; 16. people with claustrophobia.
autism and attachment. an explorative study of attachment styles in autistic adults.

Conditions: Autism Spectrum Disorder

Summary: the present study examines the relationship between attachment and autism spectrum disorder (asd) in adults.

rationale: previous research on autism spectrum disorder (asd) and attachment has improved understanding of the aetiology and development of the disorder. research on adults with asd, however is scarce. the study is focussed on attachment in adults with asd. objective: the aim of the current study is to explore attachment styles of adults with asd and examining the relationship between attachment and asd. the study requires 60 participants.

Eligibility criteria:
inclusion criteria: * inclusion criteria are: * a primary clinical diagnosis of dsm-5 asd (apa, 2013) * age 18 - 65 years * no intellectual disability (iq \> 80) exclusion criteria: * acute psychosis * acute suicidality * psychotic disorder * intellectual disability (iq \< 80)

Keywords: autism spectrum disorder attachtment adults
evaluation of visceral pleural lumbar lymphatic drainage

Conditions: Pulmonary Artery Stenosis

Summary: anatomic variations of the pulmonary arterial tree can cause technical difficulties during pulmonary lobectomy in general and video-assisted thoracic surgery (vats). using ct angiography and 3d reconstruction, the investigators sought to identify anatomic variations of the pulmonary arterial tree and assess their respective frequencies.

purpose anatomic variations of the pulmonary arterial tree can cause technical difficulties during pulmonary lobectomy in general and video-assisted thoracic surgery (vats). using ct angiography and 3d reconstruction, the investigators sought to identify anatomic variations of the pulmonary arterial tree and assess their respective frequencies. methods the investigators retrospectively studied 88 pulmonary arterial trees in 44 patients having undergone vats lobectomy for lung cancer over an 18-month period in amiens university hospital's department of thoracic surgery. each ct angiography with 3d reconstruction of the pulmonary arterial tree was performed by two experienced operators, according to a standardized procedure.

Eligibility criteria:
inclusion criteria: * any major patient aged 18 years and over who has undergone oncological lung lobectomy for non-small-cell lung cancer located in the thoracic surgery department of the university hospital of amiens. * nosologic criteria and related to acts: the pathology has already been diagnosed or suspected, and the surgical indication has been validated in the multidisciplinary thoracic oncology concertation meeting according to national recommendations. * these patients will be collected in a database already referenced in the register of the establishment of the university hospital of amiens under the reference drci t38 exclusion criteria: * criteria relating to the population: * patient under guardianship or curatorship * pathology criteria: patient with no pulmonary neoplastic disease, patient with locally advanced or metastatic bronchopulmonary cancer * criteria relating to the acts: the criteria altering the surgical specimen and thus its anatomical study: patient having had an extemporaneous examination, patient with the antecedents of ipsilateral pulmonary surgery and / or need of decortication

Keywords: pulmonary artery 3d reconstruction video-assisted thoracic surgery lobectomy ct angiography anatomic variation
heart failure and regional specific exercise training stimulus

Conditions: Heart Failure; Sedentary

Summary: the aim of this study is to determine whether heart failure patients can tolerate a four-weeks of a new exercise training regimen that targets peripheral tissues (regional specific training stimulus-rsts) and has been show to produce significant benefits in aerobic capacity and strength in healthy subjects aged 70+years who were at risk for losing functional independence.


Eligibility criteria:
inclusion criteria: * men and women between the ages of 55 and 90 * diagnosed with heart failure (nyha class ii-iii) * receiving optimal medical therapy * sedentary (≤ 30 min/wk structured physical activity) * peak vo2 between 10 and 30 ml/kg/min. exclusion criteria: * oxygen dependent * recent medications changes (within 3 months) * fixed-rate pacemakers * uncontrolled hypertension * type i diabetes * organ transplant * bariatric surgery * renal failure (stage 4 or 5)

Keywords: functional capacity exercise independence peripheral strength