Kornimate/medical-research-clean huggingface dataset:
hr-eeg contribution in prognostic evaluation of language development in children with asd

Conditions: Autism Spectrum Disorder; Language Development; Neurocognitive Disorders; Child Language

Summary: the goal of this prospective observational multicentric cohort study is to evaluate the clinical prognostic value of the speech tracking score of language development in children with asd aged from 3 years to 4 years and half at inclusion. participants will followed during 4 years with an annual visit. during these visits, each participant will be clinically evaluated (scales and tests) and performed an eeg-hr recording. two groups will be formed, one with children diagnosed with asd with language delay, and a control group composed of non-asd children without language delay, matched on age and gender with the asd group.

two groups will be formed, one with children diagnosed with asd with language delay, and a control group composed of non-asd children without language delay, matched on age and gender with the asd group. - asd group : for children in the asd group, 4 visits were planned (inclusion visit, then at one year, two years and three years). during study visit, each child will be clinically evaluated with standardized scales and tests and will performed an eeg-hr recording while listening to successive soundtracks (modulated pure tones, synthetic voice, recorded voice, real voice, with congruent and non-congruent pictorial supports). - control group : for children in the control group, 1 visit was planned : data will be collected at the inclusion visit only. during this visit, each child will be clinically evaluated with standardized scales and tests and will performed an eeg-hr recording while listening to successive soundtracks (modulated pure tones, synthetic voice, recorded voice, real voice, with congruent and non-congruent pictorial supports).

Eligibility criteria:
inclusion criteria: for all participants * child aged from 3 years to 4 years and half at inclusion. * information delivered and no parental objection for study participation. for asd group * diagnosis of asd according to dsm-v criteria. * expressive language level \< 27 months regarding on ide scale. for control group - matched on age (at +/- 3 months) and gender to asd group participants. exclusion criteria: for all participants * any illness or treatment that could significantly alter eeg-hr recording (epilepsy, anti-epileptic treatment, psychotropic drugs...). * major hearing or vision disorders. for asd group - severe and characterised neurological pathology other than asd for control group * characterised neurological or psychiatric pathology. * characteristic language delay.

Keywords: high resolution electroencephalogram child autism spectrum disorder language
study of energy expenditure in infants with ventricular septal defects

Conditions: Heart Septal Defects, Ventricular

Summary: objectives: i. compare the total daily energy expenditure in infants with ventricular septal defects vs healthy control infants.

protocol outline: height, weight, and vital signs (including oxygen saturation by pulse oximetry) are measured on day 1. resting energy expenditure, oxygen consumption (vo2), carbon dioxide production (vco2), and resting respiratory exchange quotient (rq) are measured using open circuit respiratory calorimetry on day 1. patients undergo assessment of total daily energy expenditure using the doubly labeled water method comprised of oral deuterium and oral oxygen o 18 with the next scheduled feeding on day 1. urine samples are collected prior to isotope administration, then serially for approximately 12 hours after isotope administration on day 1, and then daily on days 2-7. these samples are analyzed by mass spectrometry. on day 1, patients also undergo echocardiogram to confirm size of defect and measure the degree of pulmonary/systemic blood flow ratio and pulmonary artery pressures.

Eligibility criteria:
protocol entry criteria: --disease characteristics-- infants with moderate to large ventricular septal defect (vsd) by most recent echocardiogram who meet the following conditions: no other concurrent heart or lung disease; no chromosomal defects or congenital anomalies or healthy control infants without vsd who meet the following conditions: clinically well; no heart disease; no chromosomal defects or congenital anomalies --prior/concurrent therapy-- surgery: vsd infants -- no prior cardiac surgery or palliative procedures; vsd and control infants -- greater than 6 weeks since other prior surgery other: vsd and control infants: greater than 6 weeks since prior hospitalization

Keywords: cardiovascular and respiratory diseases heart defects rare disease
the effect of peripheral neuropathy symptoms on temporomandibular joint functionality

Conditions: Diabete Type 2

Summary: the aim of this observational case-control study was to investigate the effect of diabetic peripheral neuropathy symptoms on temporomandibular joint functionality in patients with type 2 diabetes.

the number of participants planned to be included in the study was decided with the g-power programme. while calculating the number of individuals to be included in the study, it was calculated that the sample size to obtain an effect size of 0.6 for the purpose of evaluation within the 95% confidence interval in a way to provide 80% study power at 5% type 1 and 20% type 2 error limits should be 74 (n=37) individuals. this study included 70 individuals (dm study group=40 individuals, control group=30 individuals). peripheral neuropathy symptoms of all participants were evaluated with the michigan neuropathy screening test. in the evaluation of tmj functionality, the presence of pain, maximum pain-free mouth opening, mandibular dysfunction and dysfunction were assessed with the help of scales. duration of diabetes mellitus was recorded and quality of life was evaluated with ferran powers quality of life index.

Eligibility criteria:
inclusion criteria: * individuals diagnosed with type 2 dm exclusion criteria: * having diabetic foot ulcer, * mini mental test score below 24, * history of psychiatric illness, cancer, neurological problems, congenital anomalies, musculoskeletal problems, systemic disease, facial paralysis, surgical operation related to spine, abdomen and/or tmj problem * receiving any treatment related to spine and tmj in less than 6 months

Keywords: diabetes mellitus temporomandibular joint neuropathy
comparison of dynamic contrast enhanced ct and diuretic renogram in the evaluation of upjo

Conditions: Ureteral Obstruction

Summary: renal blood flow is inversely related to obstruction. we propose that this imaging will be as effective as the diuretic renogram in the functional diagnosis of obstruction. furthermore, dynamic contrast ct scanning may also add anatomic information necessary for the surgical treatment.


Eligibility criteria:
inclusion criteria: * 18 years of age or older; * subjects suspected to have upjo. exclusion criteria: * pregnancy; * renal failure (creatinine \>150); * allergy to contrast material; * ureteral stent; * nephrostomy tube; * renal pelvis calculi.
international immune tolerance study

Conditions: Hemophilia A With Inhibitors

Summary: the purpose of this study is to see if a low-dose arm or a high dose-arm of immune tolerance is more effective in eliminating inhibitors in patients with hemophilia a.

subjects will be randomized into a low-dose or high-dose immune tolerance regimen and this study will compare the success rates, the time to achieve tolerance,the complications and the cost of both regimens.it will also aim to identify predictors of successful immune tolerance.

Eligibility criteria:
inclusion criteria: * severe hemophilia a (fviii level \<1%). * a maximum historical inhibitor titer of between 5 bu and 200 bu that must be confirmed once prior to the beginning of iti. * the inhibitor titer should be \<10 bu at the start of iti, confirmed once. * the inhibitor must be present for \<24 months when iti begins. * maximum age of 7 at the start of iti. * willingness to comply with the protocol. exclusion criteria: * moderate or mild hemophilia a (fviii level \>1%). * spontaneous disappearance of the inhibitor prior to iti. * historical maximum inhibitor titer \ 200 bu before starting iti. * inhibitor titer \> 10 bu at the start of iti. * inhibitor present for more than 24 months before starting iti. * systemic immunomodulatory drug therapy during immune tolerance e.g. corticosteroids (\< 5 days every 2 months maximum dose 2 mg/kg or 60 mg/day), azathioprine, cyclophosphamide, high-dose immunoglobulin or the use of a protein a column or plasmapheresis. * age \> 7 years at the start of iti. * inability or unwillingness to comply with the protocol. * previous attempt at iti.
digital therapeutics for behavior problems

Conditions: Problem Behavior; Child Behavior

Summary: in this project, the investigators aim to test the effectiveness of a mobile health (mhealth) system as a standalone versus coach-assisted intervention with the goal of achieving reach and scalability. parents of children (ages 5-8) with disruptive behaviors (n = 324 subjects) will be randomly assigned to group 1 (standalone app), group 2 (coach-assisted app), or group 3 (control app).

in this project, the investigators aim to test the effectiveness of a mobile health (mhealth) system as a standalone versus coach-assisted intervention with the goal of achieving reach and scalability. aim 1 is to evaluate the effectiveness of the useit! mhealth system as both a standalone and coach-assisted intervention compared to a control app condition. aim 2 is to assess target (parent management training/cognitive behavioral therapy skill acquisition and use) engagement and validation. aim 3 is to evaluate the effectiveness of the components of the useit! mhealth system. the investigators plan to recruit an anticipated total of 324 families for the study. families will be randomly assigned to group 1 (standalone app), group 2 (coach-assisted), or group 3 (control app condition). parents will use the app for four months before the administration of the post-treatment assessment. parents will be trained to use the useit! mhealth system over the phone. the coach for the group 2 condition will be a bachelor's level paraprofessional with a degree in psychology or an allied discipline (e.g., social work) who will provide support to parents. the system is very user friendly and families can be trained in approximately 30 minutes. assessments will take place at baseline, post (4 months from baseline), and 6-month follow-up. all assessments will be conducted online (qualtrics survey links sent via email by research staff) and take approximately 1 hour to complete.

Eligibility criteria:
inclusion criteria: * males or females between the ages of 5-8 years * above the 90th percentile for oppositional defiant disorder (odd) and/or conduct disorders (cd) on the vanderbilt assessment scale * residence with at least one parent/guardian at least 80% of the time * parent/legal guardian consent for participation * parent/guardian must have a smartphone device with daily internet access exclusion criteria: * a known preexisting behavioral or mental health diagnosis requiring alternative treatment (bipolar disorder, major depression, pervasive developmental disorder) * currently in treatment for childhood disruptive behavior

Keywords: oppositional defiant disorder (odd) conduct disorder (cd) childhood behavioral disorders mobile health
evaluate the performance and safety of comet pressure guidewire in the measurement of ffr

Conditions: Cardiovascular Diseases

Summary: a prospective, open-label, multi-center study designed to validate the agreement of comettm pressure guidewire and pressure wire certus® in ffr measurements

the comet china study is a prospective, open-label, multi-center study designed to validate the agreement of comettm pressure guidewire and pressure wire certus® in ffr measurements. patient with stable angina or any form of non-st elevation acute coronary syndrome, who are scheduled for diagnostic angiography and pressure wire assessment, and signed the informed consent, will be screened for enrollment in this study.

Eligibility criteria:
general inclusion criteria: 1. patient must be at least 18 years old and less than or equal to 75 years of age 2. patient or his/her legally-authorized representative agrees to sign the ec-approved icf prior to the procedure 3. patient with stable angina or any form of non-st elevation acute coronary syndrome and is clinically indicated of intra-coronary diagnostic angiography and ffr assessment angiographic inclusion criteria: moderate stenosis (30% to 70% diameter stenosis by visual estimation) is detected at diagnostic angiography general exclusion criteria: 1. patients unable to provide informed consent 2. patients in pregnant state 3. known renal insufficiency or failure (serum creatinine level of \> 2.5 mg/dl, or on dialysis) 4. allergy to the contrast 5. significant arrhythmia, such as ii degree or above of atrioventricular block, sick sinus syndrome, ventricular tachycardia 6. spastic bronchial asthma 7. st elevation coronary syndrome 8. hemodynamic instability 9. contraindication to nitroglycerin or atp 10. current participation in another investigational drug or device clinical study that may affect the ffr measurements angiographic exclusion criteria: cto lesion severe vessel tortuosity at the stenotic segments culprit vessel of non-st-segment elevation acute myocardial infarction
connection between tongue signs and bile reflux analysed with artificial intelligence

Conditions: Artificial Intelligence; Tongue; Bile Reflux

Summary: by introducing artificial intelligence into chinese medicine tongue diagnosis, we collated and collected tongue images, anxiety and depression scales and gastroscopy reports, mined and analysed the correlation between tongue images and bile reflux and anxiety and depression and constructed a prediction model to analyse the possibility of predicting bile reflux and anxiety and depression in patients based on tongue images.

firstly, after the patient signs the informed consent form, the researcher will collect pictures of the patient's tongue and obtain basic information about the patient. second, the patients are scored on the anxiety and depression scale. thirdly, after the patient undergoes gastroscopy, the patient's gastroscopy report is obtained. finally, the patient's tongue image, information and gastroscopy report are matched to construct an artificial intelligence model of tongue image and bile reflux and anxiety and depression, and the quality of the model is assessed.

Eligibility criteria:
inclusion criteria: * patients aged 18 to 80 years who wish to undergo gastroscopy. * patients have given their informed consent and signed the informed consent form. exclusion criteria: * serious heart, liver, kidney or other underlying illness, or mental illness. * patients taking anti-anxiety or depression medication within 3 months. * current h. pylori infection. * history of surgery on the digestive or biliary tract. * peptic ulcer, malignant tumour of the digestive tract, etc. * patients taking bismuth or other staining medications. * pregnant or lactating women.

Keywords: artificial intelligence tongue bile reflux
acetated ringer's solution versus saline in patients with septic shock

Conditions: Septic Shock Hyperdynamic

Summary: the primary aim of this trial is to compare the effect of acetated ringer's solution with that of saline for therapy on the incidence and development of major adverse renal events among septic shock patients. the investigators hypothesize that use of acetated ringer's solution for resuscitation among septic shock patients will reduce the incidence of major adverse kidney events.

normal saline and ringer's solutions are the preferred crystalloid fluids administered in early septic shock. however, evidence have associated saline with hyperchloremia and secondary metabolic acidosis, and renal vasoconstriction, increased incidence of acute kidney injury (aki) and mortality. the primary aim of this trial is to compare the effect of acetated ringer's solution with that of saline for therapy on the incidence and development of major adverse renal events among septic shock patients. the investigators hypothesize that use of acetated ringer's solution for resuscitation among septic shock patients will reduce the incidence of major adverse kidney events.

Eligibility criteria:
inclusion criteria: adult patients presenting to the icu diagnosed as septic shock within 24 hours. exclusion criteria: 1. pregnancy; 2. likely requirement for immediate hemodialysis or renal replacement therapy; 3. patients have already received fluids for more than 4 liters; 4. patient in extremis or death deemed imminent and inevitable.

Keywords: crystalloid renal failure renal dysfunction
pld and ifo as first-line treatment for patients with advanced or metastatic sts

Conditions: Soft Tissue Sarcoma

Summary: this study is designed to evaluate the efficacy and safety of pegylated liposomal doxorubicin (pld) combined with ifosfamide (ifo) for the first-line treatment of patients with advanced or metastatic soft tissue sarcoma (sts).

this phase ii study is designed to evaluate the efficacy and safety of pegylated liposomal doxorubicin (pld) combined with ifosfamide (ifo) for the first-line treatment of patients with advanced or metastatic soft tissue sarcoma (sts).

Eligibility criteria:
inclusion criteria: * aged 18-70 years with histologically confirmed advanced or metastatic sts * eastern cooperative oncology group performance status of 0 to 2 * life expectancy of ≥ 3 months * have not received chemotherapy before * at least one measurable lesion * lvef≥50% * have adequate bone marrow, hepatic, and renal function exclusion criteria: * osteosarcoma, ewing's sarcoma/pnet (primitive neurotodermal tumour),gist(gastrointestinal stromal tumors), rhabdomyosarcoma, dermatofibrosarcoma protuberans * patients with symptomatic brain metastases * active clinical severe infection
pilot comparison of n-of-1 trials of light therapy

Conditions: Cancer; Health Behavior; Depression

Summary: this study compares the effect of two n-of-1 trials on study compliance with an n-of-1 protocol and on satisfaction with participation in an n-of-1 trial. using within-person analyses, the study also compares the effect of different types of light therapy on mood, fatigue, sleep, physical activity, and side effects within a mild to moderately depressed cancer survivor population. ten participants will be randomized to the bright white versus dim red light therapy n-of-1 trial, while the remaining 5 participants will be randomized to a dim white versus dim red light comparator n-of-1 trial.

fatigue or low energy levels, trouble sleeping and feeling down are symptoms that represent some of the most important concerns in cancer survivors, across a range of cancer types. despite the impact of these symptoms on quality of life, previous studies have shown that few cancer survivors are receiving adequate treatment for these symptoms. light therapy involves the use of a light box (a box that lights up) in close proximity for a specified amount of time each day. there can be big differences in the way light therapy affects individual patients. patients can learn whether this therapy is helpful to them by engaging in an n-of-1 trial. an n-of-1 trial is an experiment conducted with one individual (n refers to "number of individuals in the trial"). in an n-of-1 trial of light therapy, a patient can try light therapy to learn whether it is beneficial to them. all participants will receive two light boxes. the boxes will be labeled "a" and "b." each light box will emit a different intensity of light. an app will send reminder notifications to participants' smartphones each morning to remind them which light box they should be using, depending on the week. they will be asked to use box a or box b each morning for 30 minutes per day for 12 weeks the purpose of this study is to empower cancer survivors with symptoms of fatigue, trouble sleeping or who are feeling down to learn whether light therapy is helpful for them.

Eligibility criteria:
inclusion criteria: * history of cancer (not including basal cell or squamous cell carcinoma, or carcinoma in situ) * current mild to moderate severity depressive symptoms (phq-8 score 5 to 19) * iphone user exclusion criteria: * has not completed primary cancer treatment including initial chemotherapy, surgical resection, or radiation therapy * non-english speaking * severe depression (phq-8 score \>=20) or active suicidal ideations * other severe mental illness that would preclude participation in a study that requires extensive self-monitoring, including depression with psychotic features, other psychotic disorder, bipolar disorder, severe personality disorder * \<6 months life expectancy due to cancer or other severe medical illness * other severe medical illness that would preclude ability to do daily self-tracking * unavailable for follow-up over the course of the 3 month trial

Keywords: light therapy n-of-1
mucin in sputum of cf during pulmonary exacerbation

Conditions: Cystic Fibrosis

Summary: the purpose of this study is to determine whether mucin is increased during pulmonay exacerbations in adult patients with cystic fibrosis (cf).

cf is typically associated with mucus hypersecretion in the airways. in health, mucin is the major macromolecular component and is responsible for the protective and clearance properties of the mucus gel. in a recent study we found that mucins are decreased in the sputum of adult cf patients. in this study we want to investigate the differences on the mucin and dna quantity and quality of airway secretions in during pulmoanry exacerbation.we hypothesize that during an exacerbation the mucin and dna amount is increasing. the aim of this study is to evaluate the molecular (mucins) and structure properties (mucin-dna-network) of the airway secretions in cf related to the severity of the disease. we characterize sputum composition of patients with pulmonary exacerbations. using gel electrophoresis and dot-blot with specific antibodies we will analyze muc5ac and muc5b mucins. dna amount will be measured by microfluorimetry. with the laser scanning confocal microscopy the mucin-dna-network will be evaluated. the significance of these studies is that they will give us novel information about the pathogenesis of chronic inflammatory airway diseases, provide tools for assessing the progression of lung disease, and most critically, will identify novel opportunities and targets for therapeutic intervention.

Eligibility criteria:
inclusion criteria: * cystic fibrosis * chronic pseudomonas aeruginosa inflammation * pulmonary exacerbation exclusion criteria: -

Keywords: lung airway pulmonary exacerbation mucus
impact of pulmonary follow-up after stem cell graft

Conditions: Hematologic Neoplasms

Summary: allogeneic hematopoietic stem cell transplantation is the only possible treatment for many malignant and non-malignant hemopathies. the graft-versus-host immunological reaction (gvh) is a frequent and sometimes serious complication. the objective is to study whether a systematic and early follow-up by a lung specialist of allografted patients would allow an earlier diagnosis of gvh with pulmonary complications.


Eligibility criteria:
inclusion criteria: * 18 years of age or older * patients with a hematopoietic stem cell transplantation exclusion criteria: * death within 100 days post-surgery
spherical aberration and contrast sensitivity function in eyes implanted with spherical and aspheric intraocular lenses: a clinical trial

Conditions: Cataract

Summary: aspheric intraocular lenses can effectively reduce higher-order aberrations and improve contrast sensitivity function after cataract surgery.


Eligibility criteria:
inclusion criteria: * senile cataract exclusion criteria: * glaucoma, corneal opacity, retinal abnormality, previous history

Keywords: higher-order aberrations, contrast sensitivity