Kornimate/medical-research-clean huggingface dataset:
understanding chronic lymphocytic leukemia

Conditions: Chronic Lymphocytic Leukemia

Summary: the purpose of this study is to collect human chronic lymphocytic leukemia tissue samples and medical information, in order to find out more about the causes and biology of chronic lymphocytic leukemia.

the purpose of this study is to collect human chronic lymphocytic leukemia tissue samples and medical information, in order to find out more about the causes and biology of chronic lymphocytic leukemia, for the potential development of more effective therapies for this disease.

Eligibility criteria:
inclusion criteria: * new and existing patients seen for treatment of monoclonal b-cell lymphocytosis * any low grade lymphoproliferative disorder * chronic lymphocytic leukemia in the dana farber cancer institute hematologic oncology clinic or elsewhere exclusion criteria: -

Keywords: chronic lymphocytic leukemia
characterization of fecal microbiome changes after administration of prim-dj2727 in parkinson's disease patients

Conditions: Parkinson's Disease

Summary: the purpose of this study is to characterize the intestinal flora in subjects with parkinson's disease (pd) and to determine safety and trends in improvements in diversity of colonic microbiome following fecal microbiota transplantation.


Eligibility criteria:
inclusion criteria: * diagnosis pd with a hoehn and yahr stage of \< 3 in the "off medicine" state * sexually active male and female subjects of child-bearing potential must agree to use an effective method of birth control during the treatment and follow-up period * female subjects of child-bearing potential must have a negative pregnancy test in the 72 hours before the procedure * subject willing to sign an informed consent form * subject deemed likely to survive for ≥ 1 year after enrolment * subject's attending physician will refer and provide non-transplant care for the subject * subjects must demonstrate adherence to and the ability to maintain a parkinson's therapy medical regimen that is stable for 90 days before enrolment and participation in the study. exclusion criteria: * greater than 20 grams of ethanol intake daily * unstable parkinson's disease * other immune disorder or clinical immunosuppression * probiotic used during study period * severe underlying disease such that the subject is not expected to survive for one or more years or unstable medical condition requiring frequent change in treatments * current or recent within one month receipt of an antibiotic with expected activity against enteric bacteria * prior deep brain stimulation, or surgical intervention for pd , intravenous glutathione therapy or stem cell therapy * hiv or hepatitis b / c positive

Keywords: fecal microbiota transplantation
effects of switching from racemic methadone to r-methadone on qtc intervals

Conditions: Adverse Drug Effect; Drug Effect; Heart Arrhythmia

Summary: effects of switching from racemic methadone to r-methadone on serum methadone concentrations and qtc intervals

racemic methadone may prolong the qtc interval, which is associated with fatal arrhythmias. in vitro studies have shown that r-methadone has less inhibitory effect than s-methadone on the voltage-gated potassium channel current, and is thus thought to have less effect on the qtc interval. the investigators hypothesized that switching from racemic to r-methadone would reduce the methadone serum concentration and also its effect on the qtc interval.

Eligibility criteria:
inclusion criteria: * stabilized on daily methadone dose * not using other drugs of abuse * qtc-time recorded automatically, patient inclusion if qtc interval was greater or equal to 450 ms * older than 18 years * can sign and understand a written consent exclusion criteria: * can not cooperate regarding observed daily drug intake * serious psychiatric disease * untreated serious somatic disease * pregnancy

Keywords: racemic methadone r-methadone qtc interval methadone maintenance treatment patients
voice therapy with a semi-occluded vocal tract

Conditions: Voice Disorders

Summary: 1. the first objective of this research is to investigate the immediate effects of three semi-occluded vocal tract (sovt) exercises (straw phonation in air, straw phonation in 2cm water, and straw phonation in 5cm water) on (supra)glottic activity of vocally healthy participants and patients with voice disorders (dysphonia) visualized with laryngovideostroboscopy. participants will receive a flexible laryngovideostroboscopy, both during normal phonation and during the specific sovt exercise. these videos will be randomly and blindly evaluated by two experts using the voice-vibratory assessment with laryngeal imaging (vali) rating form (poburka et al., 2017). researchers will compare the effects of these sovt exercises on the (supra)glottic activity with the effects found in a control group producing /u/ phonation, using a randomized controlled trial. 2. the second objective of this research is to investigate the short- and long-term effects of the three sovt therapy approaches on the (supra)glottic activity, voice quality and self-report of patients with voice disorders (dysphonia). participants will receive a short-term intensive therapy with the specific sovt exercise across four weeks. immediately after the therapy program and at 1 and 3 months follow-up, the voice of the participants will be re-evaluated.


Eligibility criteria:
patients: inclusion criteria are aged between 17 and 50 years, and diagnosed with dysphonia by an otorhinolaryngologist and slp experienced in voice diagnostics. exclusion criteria are previous or current participation in voice therapy, previous phonosurgical interventions, pregnancy, smoking, nasal or ear diseases, and neurological disorders. vocally healthy participants: inclusion criteria are aged between 17 and 50 years. exclusion criteria are dagnosed with dysphonia, previous or current participation in voice therapy, previous phonosurgical interventions, pregnancy, smoking, nasal or ear diseases, and neurological disorders.

Keywords: voice semi-occluded vocal tract larynx randomized controlled trial efficacy study
accuracy of mpmri and mri-targeted, ultrasound-navigated prostate fusion biopsy in detection of prostate cancer

Conditions: Prostate Cancer

Summary: the investigators examined whether a high pi-rads v2 score correlates with the presence of prostate cancer. in addition, the investigator inspected whether the lesion size as determined by mpmri correlates with the presence of prostate cancer. furthermore, the investigators study aimed to determine the sensitivity and specificity of mpmri with respect to prostate carcinoma detection.

purpose: in recent years, multiparametric magnet resonance imaging (mpmri) has been established as a diagnostic imaging technique of the prostate and its assessment standardized with the "prostate imaging - data and reporting system" (pi-rads v2). the previously established likert scale from 1 to 5 has been shown to reflect the increasing probability of a carcinoma. suspicious mri lesions can be biopsied in a targeted fashion using ultrasound navigation termed fusion biopsy. the investigators examined whether a high pi-rads v2 score correlates with the presence of prostate cancer. in addition, the investigators inspected whether the lesion size as determined by mpmri correlates with the presence of prostate cancer. furthermore, the investigators study aimed to determine the sensitivity and specificity of mpmri with respect to prostate carcinoma detection. materials and methods: this prospective study includes 228 consecutive patients, which underwent a perineal mri-trus-fused prostate biopsy (biopsee®, medcom company) during the period of september 2015 to march 2017 at the cantonal hospital winterthur due to a suspicious psa value, a suspicious digital rectal examination or a known prostate cancer under active surveillance. 71 patients were excluded due to lack of pi-rads v2 diagnosis and / or mri performed at a different center. targeted biopsies were performed specifically in the indicated mri lesions and standardized over the rest of the prostate (system biopsy).

Eligibility criteria:
inclusion criteria: * patients with mri-trus fusion prostate biopsy * age \> 18y * elevated psa * suspicious dre (digital rectal examination) * patients with prostate cancer under active surveillance exclusion criteria: * age \< 18y * treated prostate cancer (radiotherapy, antiandrogens therapy, brachytherapy, hifu).

Keywords: prostate cancer mpmri-trus fusion biopsy pirads gleason score
use of protamine for heparin reversal after catheter ablation of atrial fibrillation

Conditions: Atrial Fibrillation; Catheter Ablation

Summary: the objective of this study is to evaluate the safety, efficacy and efficiency of rapid anticoagulation reversal with protamine sulfate versus routine activated clotting time (act) monitoring in patients undergoing catheter based ablation of atrial fibrillation.


Eligibility criteria:
inclusion criteria: * patient's referred for radiofrequency ablation (rfa) or cryoablation for atrial fibrillation or atrial flutter (left atrial). * age ≥ 18 year * patients who are mentally and linguistically able to understand the aim of the trial, comply with the trial protocol, verbally acknowledge the risks, benefits, and alternatives in this trial. exclusion criteria: * previous intolerance or allergy to heparin products. * current or prior administration of protamine products * history of femoral access site complications including hematoma, av fistula, pseudoaneurysm, aneurysm. * known lower extremity venous thrombosis. * coagulopathy or blood dyscrasias. * active malignancy. * thrombocytosis (platelet count \>600k/ul) or thrombocytopenia (platelet count \<100k/ul) * planned use of vascular closure device

Keywords: atrial fibrillation catheter ablation protamine sulfate anticoagulation reversal
contact lenses and infiltrative keratitis

Conditions: Keratitis

Summary: to quantify and compare baseline tear proteins and ocular response in contact lens wearers with a history of corneal infiltrative events, to those without a history of complications. this will be accomplished via measurement of select anti-inflammatory tear proteins before, during and after contact lens wear.


Eligibility criteria:
inclusion criteria: * soft contact lens wearers * healthy (control), or with history of infiltrative keratitis (case) * has a wearable pair of glasses * refractive error between +8.00 d and -12.00 d, with less than 1.50 d of astigmatism exclusion criteria: * smoker * pregnant or nursing * systemic disease that would effect tear proteins * punctal plugs * use of eye drops in the last week

Keywords: contact lenses
does bio-rsa provides superior clinical outcome compared to conventional rsa?

Conditions: Arthroplasty, Replacement, Shoulder; Shoulder Osteoarthritis

Summary: the goal of this clinical trial is to compare two different types of reverse shoulder replacements. researchers will compare a conventional reverse shoulder replacement with a lateralized reverse shoulder replacement to see if there is a difference in how well the patients function after two years.

many studies have showed pain relief and improvement in shoulder function following reverse shoulder arthroplasty (rsa), but medialization of the centre of rotation (cor) in rsa may cause complications like limited range of motion (rom), luxation of the prosthesis, and scapular notching, where the lower part of the scapular neck becomes eroded due to impingement against the humeral component. joint centre lateralization with a bone transplant placed underneath the glenoid component (bio-rsa) was introduced to maximize rom in the prosthetic joint, increase stability and to prevent scapular notching. in recent years it has been claimed that lateralization of the cor with bio-rsa decreases the risk of the aforementioned complication, but no consensus on when or how to lateralize the cor exists as of today. this knowledge will also be of critical importance when it comes to decision making on how these patients are best treated. results from this research project is expected to have a significant impact on how these patients are treated in the future, both nationally and internationally. the purpose of this study is to compare functional results between patients with bony increased offset-reversed shoulder arthroplasty (bio-rsa) and conventional reverse shoulder arthroplasty (rsa) to investigate if lateralization of the glenosphere yields superior outcomes and fewer complications after 2 years. this multicenter study will include 130 patients in 4 hospitals scheduled for rsa. patients will be asked to participate in a blinded rct, where they are randomly assigned to either bio-rsa or conventional rsa. functional results will be measured primarily by the patient-reported outcome measure western ontario osteoarthritis shoulder (woos), but they will also be examined by a physiotherapist and ct imagery will be assessed by a radiologist.

Eligibility criteria:
inclusion criteria: * eligible for primary rsa due to oa, massive rc tear, failed rc repair or post-instability osteoarthritis * able to read or write norwegian exclusion criteria: * severe osteoporosis * osteonecrosis of the humeral head * dementia * poor deltoid function * revision surgery * asa iv * suspected chronic infection * acute fracture

Keywords: reverse shoulder arthroplasty bio-rsa orthopedic surgery
the effect of stress ball used during endoscopy

Conditions: Pain; Anxiety; Satisfaction

Summary: endoscopy procedure is a frequently used method in the evaluation of the gastrointestinal system. upper gastrointestinal system endoscopy can be performed with and without sedation. sedation is the controlled sleep of the patient with certain drugs (pharmacological methods). non-pharmacological methods help reduce anxiety and pain. in this study, a non-pharmacological stress ball will be used. it is aimed to evaluate the effect of using a stress ball on pain, anxiety and satisfaction during upper gastrointestinal system endoscopy.

patients do not want to think that an upper gis endoscopy without sedation will be difficult. however, some complications can be seen like hypoxemia, allergic reaction, malignant hyperthermia, hypoventilation, respiratory depression, hypotension, bradycardia, apnea, hypoxia, etc. due to sedation applied during endoscopy. non-pharmacological methods help reduce anxiety and pain. although sedative and analgesic medications reduce anxiety and relieve pain, endoscopy is still painful for patients. during the endoscopy process, non-pharmacological methods are used to draw attention to another direction, but it is not encountered that the stress ball is used as one of these methods in the endoscopy procedure. this study was planned as a single-center prospective randomized controlled study for the treatment of the stress ball method used during the endoscopy procedure, pain in anxiety and satisfaction levels. the data obtained in the study will be analyzed using the spss (statistical package for social sciences) for windows 22.0 program. number, percentage, mean, standard deviation will be used as descriptive statistical methods in the evaluation of data. in comparing the difference between two independent groups, student's t test will be used for data conforming to normal distribution, and mann-whitney u test will be used for data that do not comply with normal distribution. the difference between two repeated measurements will be analyzed with dependent groups t-test for data conforming to normal distribution, and wilcoxon test for data that do not conform to normal distribution. the difference between three and more measurements that do not comply with the normal distribution will be compared with the analysis of variance in repeated measures for data that do not fit the normal distribution, and with the friedman test for data that do not comply with the normal distribution. a value of p \<0.05 will be considered as statistically significant.

Eligibility criteria:
inclusion criteria: * to have an upper gastrointestinal endoscopy for the first time * not wanting sedation during upper gastrointestinal endoscopy * being between the ages of 18-75 * being willing to participate in research exclusion criteria: * using analgesic or anesthetic drugs before or during the procedure * using antidepressants, anxiolytic and sedative drugs * having communication difficulties and mental disability

Keywords: anxiety endoscopy pain nursing stress ball
multiple intravenous dose study of pf-04360365 in japanese patients with mild to moderate alzheimer's disease

Conditions: Alzheimer's Disease

Summary: the purpose of the study is to examine the safety and tolerability of a multiple dose of pf-04360365 administered over approximately 10 minutes in japanese patients with mild-to-moderate alzheimer's disease and to characterize the pharmacokinetics of pf-04360365 following administration of multiple doses in japanese patients with mild-to-moderate alzheimer's disease.


Eligibility criteria:
inclusion criteria: * japanese males or females of non childbearing potential, age \> or = 50 * diagnosis of probable alzheimer's disease, consistent with criterial from both: * national institute of neurological and communicable disease and stroke and alzheimer's disease and related disorders association (nincds-adrda) * diagnostic and statistical manual of mental disorders (dsm iv) * mini-mental status exam score of 16-26 inclusive * rosen-modified hachinski ischemia score of \< or = 4 exclusion criteria: * diagnosis or history of other demential or neurodegenerative disorders * diagnosis or history of clinically significant cerebrovascular disease * specific findings on magnetic resonance imaging (mri); cortical infarct, micro hemorrhage, multiple white matter lacunes, extensive white matter abnormalities * history of autoimmune disorders * history of allergic or anaphylactic reactions

Keywords: alzheimer's disease amyloid antibody japanese
quality of life and body image in women underwent thighplasty

Conditions: Obesity

Summary: obesity is a chronic disease now considered a major public health concern in the global context, as it causes or exacerbates many diseases limitations in providing quality of life and higher treatment costs. the increase in the number of patients undergoing bariatric surgery and the excess skin and subcutaneous tissue adjacent to slimming collaborate in the search for growth by plastic surgery. currently several techniques of thighplasty has been submitted but no studies were found that evaluated the characteristic clinical and emotional resulting from this procedure. this study has as a goal to evaluate the body image and quality of life in women submitted to thighplasty.

the patients have been evaluated for two different questionnaires, the body dysmorphic disorder examination (bdde) and impact weight on quality of life - lite (iwqol-lite). the sample consists of 50 patients with the desire to undergo to the thighplasty. however 25 are from study group and 25 control group. just the study group was undergoing plastic surgery. the questionnaires have applied by signing the consent form, after 3 and 6 months both groups. this study is a clinical trial, control, primary, longitudinal, no random, analytical, held in a single center.

Eligibility criteria:
inclusion criteria: * abdominoplasty previous * control of systemic disease * adults at the age of 35 and 50 years old * had reached massive weight loss less by bariatric surgery or similar than 30 kg/m2 for a minimum of 12 months or more. * gender: female * for control group: it supposed to be on the waiting list for thighplasty * for study group:they are supposed to be scheduled for thighplasty exclusion criteria: * illiterate * pregnant women and/or women who have been nursing for one year or less * non-controled of systemic disease

Keywords: bariatric surgery plastic surgery thigh obesity body image quality of life
effect of menstrual cycle on central nervous system (cns) processing of gut stimuli in irritable bowel syndrome (ibs) and control

Conditions: Irritable Bowel Syndrome

Summary: the hypothesis of the study is that women perceive intestinal stimulation (rectal balloon distention) differently in different phases of the menstrual cycle, i.e there is an effect of hormones on the sensory pathway, and that this difference is reflected in the central nervous system processing of this signal. we also hypothesize that there is a difference in perception between control subjects and subjects with the irritable bowel syndrome.

there is discrepancy in the literature concerning the effect of the menstrual cycle on bowel function and pain syndromes such at irritable bowel syndrome. in addition, recent studies indicate a difference in the cns processing of rectal stimulation in normal subjects and patients with ibs. this study will determine the differences in the perception of rectal balloon distention in the follicular and luteal phases of the menstrual cycle, in control subjects with no bowel symptoms and volunteers with ibs, and will compare the cns processing of this signal using functional mri , again in the two phases of the menstrual cycle. comparisons: between control subjects without gi symptoms and those with irritable bowel syndrome.

Eligibility criteria:
inclusion criteria: * controls - normal bowel function * irritable bowel syndrome - rome ii criteria * normal menstrual cycle exclusion criteria: * irregular menses * pregnancy * use of psychotropic medication * claustrophobia * metal implants * metal in eyes

Keywords: functional mri pain perception anxiety brain-gut axis