Kornimate/medical-research-clean huggingface dataset:
heart sounds measurement using the wearable cardioverter defibrillator (hs-wcd) study

Conditions: Heart Failure

Summary: a prospective, validation study to evaluate the data accuracy of heart sounds recorded by the lifevest® wearable cardioverter defibrillator (wcd). these data will be compared with the heart sounds data recorded by an fda-cleared device audicor am device.

to conduct a prospective, validation study to evaluate the data accuracy of heart sounds recorded by the lifevest® wearable cardioverter defibrillator (wcd). to show equivalence, these data will be compared with the heart sounds data recorded by an fda-cleared audcior am device . the study will enroll a minimum of 27 and a maximum of 35 subjects. participants will be adult patients (age ≥ 18 years) with at least seven patients over the age of 40 years. in addition, at least five patients with a history of heart failure will be included. first, participants will wear the audicor-am device for 15 minutes while sitting quietly. then, the audicor device will be removed and the participants will wear the wcd for 15 minutes while sitting quietly. next, while wearing the wcd, participants will perform various activities of daily living, including at least 6 hours of overnight wear. finally, the wcd will be removed and the participants will wear the audicor again for 15 minutes while sitting quietly. this is a single center, prospective, observational study. this is a non-significant risk device study as all biological study parameters will be measured noninvasively with the wcd defibrillation capability disabled. in addition, the study device will not be used as a replacement for regularly prescribed therapies or diagnostics.

Eligibility criteria:
inclusion criteria: * healthy male and female volunteers who are able to fit in the wcd garment (26 to 56 inches measured circumferentially at the level of the xiphoid process). * included in this group are at least five healthy subjects with a self-reported history of heart failure. * the subject must be 18 years of age or older on the day of screening, with at least 7 subjects 40 years of age or older on the day of screening. exclusion criteria: * mental, visual, physical, literacy, and auditory limitations that prevent interaction with the wcd equipment. * any acute medical conditions that prevent the following maneuvers: lying on back, lying on the right and left side, standing, sitting, and/ or leaning forward when sitting. * any self-reported shortness of breath, fatigue, swelling of feet, ankles, or legs, and/or chest pain * employees or family members of the sponsor. * unable or unwilling to provide written informed consent.
the efficacy of pilates in the recovery of post-prostatectomy urinary incontinence

Conditions: Prostate Cancer; Urinary Incontinence

Summary: the purpose of this study is to compare the efficacy between a pilates exercise program and a pelvic floor muscle training (pfmt) protocol combined with anal electrical stimulation (aes) in the recovery of urinary continence (ui) after radical prostatectomy. there are no studies that evaluate pilates mat exercises for incontinence in men although it can be assured that this method has the pelvic floor contractions as a principle for practice. if this new therapeutic approach proves to be as effective as described treatment in improving urinary complaints, it will be an option for patients who prefer a non-invasive treatment.

this randomized clinical trial includes 69 individuals with urinary incontinence one month after radical prostatectomy. one physiotherapist, with experience in urogynecology, was responsible for all the assessments. urinary frequency, nocturia, 24-hour pad test, number of pads used per day, and the international consultation on incontinence questionnaire - short form (iciq-sf) were the variables evaluated. the subjects were allocated in one of two treatment groups (g1: pilates; g2: anal electrical stimulation combined with pelvic floor muscle training). volunteers participated of 10 sessions of the corresponding treatment and were reassessed objectively by the number of pads used per day, and subjectively with the score of quality of life.

Eligibility criteria:
inclusion criteria: * volunteers between 50 and 75 years old; * submitted to radical prostatectomy; * with complaints of urinary incontinence; * that completed one month of surgery; exclusion criteria: * history of incontinence; * transurethral resection of the prostate; * diagnosis of neurological or cognitive impairment; * subjects who were unable to attend treatment sessions, due to distance or physical limitations.

Keywords: prostatectomy urinary continence physical therapy modalities pelvic floor randomized trial.
neuroprotective study of electroacupuncture pretreatment in patients undergoing cardiac surgery

Conditions: Stroke; Brain Injuries

Summary: the purpose of this study is to evaluate the neuroprotective effect of electroacupuncture pretreatment in patients undergoing cardiac surgery as an preventive sequela in a randomized and controlled clinical trial. in addition, to investigate the role of inflammatory responses in the precess of the protection.

heart valve replacement surgery has been proved to be an effective method in treating both regenerative and rheumatic valve disease. current studies showed that cardiopulmonary bypass (cpb) and operation related cerebral injury is associated with worse patient morbidity and mortality after elective valve replacement surgery. recently, electroacupuncture (ea) pretreatment was proved to produced cerebral protective effects by mimicking ischemic preconditioning in animal models. however, the evidence that ea pretreatment can improve the clinical outcomes such as mortality and morbidity, is still lacking. the investigators perform a randomized controlled study to evaluate that ea pretreatment can improve the outcomes of cardiac surgery. purpose: the purpose of this study is to examine if ea pretreatment can decrease the mortality and postoperative cerebrovascular complications in patients undergoing cardiac surgery. the effect will be assessed by mortality, scores of neurological defect, post operative cognitive dysfunction and stroke. methods: study patients will be randomized to cardiac surgery with ea pretreatment or conventional cardiac surgery in the department of cardiovascular surgery, xijing hospital. ea pretreatment is performed at baihui acupoint 30 min per day 5 consecutive days before the heart valve replacement surgery．primary study outcome is cerebrovascular complications within 6 postoperative months. secondary outcomes include the s-100b and nse blood level measured during the first 72 hours of surgery follow-up, the several cytokines, including tnf-a, il-8, il-6, il-10 and hmgb-1 blood level measured during the first 7 days of surgery follow-up, all cardiovascular haemodynamic parameters as measured by a pulmonary artery catheter, the length of intensive care unit (icu) stay and length of postoperative hospital stay.

Eligibility criteria:
this study enrolls a group of 40-65years patients who have heart valve disease who need valve replacement. inclusion criteria: * patients who have the indication for aortic or mitral valve replacement * patients would like to accept the follow-up and sign the informed consent * patients with heart function of nyha i-iii degree. exclusion criteria: * pregnant or nursing women * comorbid with coronary artery disease * patients with heart function of nyha iv degree * renal dysfunction with serum creatinine level\>or=2mg/dl(177umol/l) * anticipated life span \< 12 months * enrollment in other clinical trials at the same time not reaching the primary endpoint and probably interference the present trial.

Keywords: brain protection cardiac surgery heart valve replacement electroacupuncture pretreatment preconditioning thoracic surgery
acute-phase response & periodontal treatment in diabetes affected patients

Conditions: Periodontitis; Diabetes

Summary: thirty-eight periodontitis- and diabetes-affected subjects will be randomly allocated to non surgical periodontal treatment with either full-mouth approach (fm-srp) or quadrant approach (q-srp). patients will be seen one day and three months (study completion) after treatment. the 24 hours appointment will be occurring after the entire completion of the fm-srp or the first quadrant of the q-srp. in the latter group other sessions of treatment will be performed within the following 3 weeks. at baseline, 24 hours and three months, anthropometric, inflammatory and endothelial parameters will be collected. periodontal parameters will be checked at baseline and at three months. main outcome of the study is the level of c-reactive protein 24 hours after treatment.


Eligibility criteria:
inclusion criteria: * patients affected by periodontal disease * 20% of periodontal pockets of the entire dentition * 20% bleeding on probing of the entire dentition * documented radiographic bone loss * diagnosis of diabetes type 2 as measured through international standards exclusion criteria: * age younger than 18 years and older than 80 years * pregnant or lactating females * females using contraceptive methods * need of antibiotic coverage for periodontal treatment * previous periodontal treatment in the last 6 months.
the water intake trail and primary aldosteronism postoperation(wit-pap)

Conditions: Hyperaldosteronism; Renal Insufficiency

Summary: to investigate whether increasing water intake has renal protective effect on pa patients after surgical treatment.

this is a single-center randomized controlled trial study to verify the effect of drinking water on renal function after pa surgery treatment and to follow up the clinical outcomes. we will take short-term follow-up on whether increasing water intake can improve egfr decline in the early stage of pa patients after surgical treatment and further long-term follow-up to investigate whether increasing drinking water has long-term memory effect to slow down renal function deterioration and improve clinical outcomes. this study will be completed in 1 year.

Eligibility criteria:
inclusion criteria: * age 18-75 years * able to provide informed consent and willing to complete follow-up visits. * estimated glomerular filtration(egfr) rate over 60 ml/min/1•73 m² * according to the guideline of primary aldosteronism, unilateral pa has been diagnosed and unilateral adrenalectomy has been completed * urine volume can be recorded consciously, and daily drinking water volume is less than 2l/d exclusion criteria: * pregnant or breastfeeding * diagnosed with other types of chronic kidney diseases, such as iga nephropathy, lupus nephritis, etc. * history of malignant tumor * history of kidney stones in past 5 years * kidney transplant within past six months (or on waiting list) * less than two years life expectancy * serum sodium \ 2.6 mmol/l without suitable explanation * currently taking hydrochlorothiazide \>25 mg/d, indapamide \>1.25 mg/d, furosemide \>40 mg, or metolazone \>2.5 mg/d * poor blood pressure control (systolic pressure\>180mmhg or diastolic pressure\> 110mmhg) * alcoholics, drug addicts, and people with mental disorders who cannot cooperate * patient is under fluid restriction (\<1.5 l a day) for kidney disease, heart failure, or liver disease, and meets any of the following criteria: i) end stage of the disease (heart left ventricular ejection fraction \<40%, nyha class 3 or 4, or end stage cirrhosis) , ii) hospitalization secondary to acs,heart failure, stroke,ascites and/or anasarca ,iii)severe anemia (hb\<60g/l)

Keywords: primary aldosteronism surgery therapy water intake renal function
transform type 2: examining meal-delivery and education for diabetes self-care

Conditions: PreDiabetes; Diabetes Mellitus, Type 2

Summary: the purpose of this research is to understand the impact of medically tailored meals on health-related biometrics (e.g., glucose time-in-range, waist-hip ratio, cholesterol) and how providing medically tailored meals promotes engagement in diabetes education and drives information-seeking behavior.

the purpose of this research is to understand the impact of medically tailored meals on health-related biometrics (e.g., glucose time-in-range, waist-hip ratio) and how providing medically tailored meals promotes engagement in diabetes education and drives information-seeking behavior. secondary purposes are to characterize the relationship between information-seeking behaviors and glycemic control; to characterize the relationship between psychometric survey results and program engagement, biometrics, and information-seeking behaviors; and to understand how meal provision and materials influence program satisfaction and adherence to healthy diabetes-related behaviors.

Eligibility criteria:
inclusion criteria: * be a patient, employee, or employee dependent at utica park clinic in oklahoma * be diagnosed with type 2 diabetes, prediabetes, and/or have an a1c result of 5.7 percent or above * be above an ideal weight (for example, body mass index \[bmi\] greater than or equal to 25) * 18 years of age or older * have unitedhealthcare insurance for 1 year+ * have an active e-mail address * have a smartphone with access to the internet that is compatible with the dexcom g6 app exclusion criteria: * be undergoing any form of cancer treatment * be pregnant or breastfeeding * have allergies to nightshade vegetable (e.g., bell peppers, potatoes, tomatoes) or legumes (e.g., green beans, peas), or tree nuts * currently taking anti-psychotic medications to control schizophrenia and bipolar disorders, as well as other mental disorders including dementia, major depression, and even drug addiction * be currently taking insulin * be currently taking sulfonylureas

Keywords: diabetes mellitus, type 2 information seeking behavior waist-hip ratio blood pressure weight prediabetes glycemic control diet life style cholesterol meal delivery nutrition continuous glucose monitoring cgm self report education coaching yoga meditation human
disease outcomes and toxicities in patients with gastrointestinal and sarcomatous malignancies

Conditions: Sarcoma; Gastrointestinal Cancer

Summary: this prospective, single-institution, observational study explores disease outcomes and toxicities in subjects with gastrointestinal malignancies and sarcoma (bone and soft tissue) who are being treated with standard-of-care therapies including radiotherapy. recent advances in treatment approaches affected disease outcomes and toxicities. prospective monitoring of disease outcomes and toxicities using standardized assessments will provide information about recent changes in the standard of care and further refine treatment approaches and prospective clinical trial design.


Eligibility criteria:
inclusion criteria in order to participate in this study a subject must meet all of the eligibility criteria outlined below. 1. subject is willing and able to provide written informed consent to participate in the study and hipaa authorization for the release of personal health information. subjects are willing and able to comply with study procedures based on the judgment of the investigator or protocol designer. 2. age ≥ 18 years at the time of consent. 3. histological, cytological, or radiographic evidence/confirmation of a gastrointestinal malignancy or sarcoma. 4. females with childbearing potential and male subjects with fathering potential are allowed to participate in this study. exclusion criteria all subjects meeting any exclusion criteria at baseline will be excluded from study participation. 1. inability or unwillingness to provide informed consent 2. patients who state they do not expect to be available or willing to follow up at expected intervals post-treatment

Keywords: toxicity survey
evaluation of the emotional burden of the nurse

Conditions: Burnout, Professional

Summary: asses the emotional burden on nursing staff and how much they are at risk for burnout.

the study involves the administration of a questionnaire paper questionnaire (maslach burnout scale) in the presence.

Eligibility criteria:
inclusion criteria: * nursing personnel afferent to the ou of hematology and stem cell transplantation hematopoietic and the uoc geriatric hematology and rare hemapathies with more than 2 years of experience in the above departments. * signature of informed consent. * ability to understand and complete. exclusion criteria: * nursing staff not belonging to the departments of hematology * failure to sign informed consent
the effect of american ginseng root and its components on glycemia in healthy individuals

Conditions: Hyperglycemia

Summary: to determine the effect of polysaccharides from american ginseng root on postprandial glycemia in healthy individuals.

glycemia-lowering effects of american ginseng root have been repeatedly observed in healthy individuals and in type 2 diabetes. it is unclear which components trigger these effects. pre-clinical evidence suggests that, aside from ginseng saponins, ginseng polysaccharides may reduce glycemia. this assumption has not been investigated so far in humans. we therefore undertook a double-blind randomized controlled clinical trial to determine the effect of american ginseng root polysaccharides, at escalating doses, on postprandial glycemia, in comparison to the american ginseng root and control in healthy individuals. we hypothesized that polysaccharides will reduce glycemia comparably to a dose of ginseng root that contains polysaccharides at an equivalent amount to the average polysaccharide dose. we therefore tested polysaccharide doses equivalent to 9, 12 and 15 g of rot, 12 go of ginseng root and a wheat bran control. each subject received each treatment in random sequence, after a 12-hour overnight fast and 40 minutes prior to a 25-g oral glucose tolerance test. capillary blood samples were collected at baseline, prior to glucose ingestion and at 15, 30, 45, 60, 90, 120 minutes after the start of glucose intake. capillary blood glucose was measured.

Eligibility criteria:
inclusion criteria: * 16-65 years old * normal renal and hepatic function * fasting plasma glucose: 4-6 mmol/l * clinically euthyroid * normotensive exclusion criteria: * pregnant * taking herbs, supplements or medication that affect glycemia * major illnesses/ disease * heavy alcohol use (\> 3 drinks/ day) * heavy smoking (\> 10 cigarettes/ day)

Keywords: ginseng polysaccharides postprandial glycemia area under the glucose curve peak incremental glucose
attention deficit hyperactivity disorder

Conditions: Attention Deficit Hyperactivity Disorder; Behavior Hyperactive; Behavior Disorders

Summary: the ada cohort aims for the systematic and standardized collection of sociodemographic, clinical and neuropsychological data, during 2 visits (inclusion and 12 months), from patients suffering from the co-occurrence of adhd (attention deficit hyperactivity disorder) and addiction(s), in addition to the treatment as usual adapted to each situation.

information on the study and diagnosis of adhd will be carried out during a medical evaluation consultation, as part of routine care. the two research visits (inclusion and at 12 months) will be added by the research and will each include: * a structured clinical interview with a research professional (traceability of oral consent, administration of structured interviews, collection of self-questionnaires, collection of care from the medical record) * a neuropsychological assessment with a neuropsychologist

Eligibility criteria:
inclusion criteria : * patients aged over 15 years and 3 months * for whom a diagnosis of adhd has been confirmed less than 6 weeks ago * for whom the diagnosis of one or more addictive disorder(s) (substance use disorder or behavioral addiction) has been confirmed * meeting the indication for treatment with mph according to european recommendations (kooij et al., 2019) * for patients who can actually benefit from mph: who have not yet started taking mph * social security affiliates exclusion criteria : * presenting disorders of higher cognitive functions (at the discretion of the referring clinician or the investigator making the inclusion), making data collection impossible * presenting difficulties in reading or writing the french language making data collection impossible * unable to commit to being available for the 2 visits planned as part of the cohort * under guardianship or legal protection

Keywords: attention deficit disorder with hyperactivity addictive disorders neuropsychology methylphenidate atomoxetine functional impairment symptoms
treatment of calcium deficiency in young women

Conditions: Osteoporosis

Summary: this study looks at the effects of calcium supplementation on bone density in women in their third decade of life. we placed women aged 19-27 who take in low amounts of calcium in their diets in one of two groups. we will give women in one group a placebo (inactive pill) and women in the other group 1500 milligrams of calcium per day (as calcium carbonate). we will monitor the results by looking at the change in bone mineral density measured at the hip, total body, forearm, and spine. treatment will last 3 years.

this is a randomized, controlled trial of calcium carbonate supplementation (1500 milligrams per day) in third-decade women with low calcium-to-protein intakes. we accept women aged 19-27 on the basis of good health and the 7-day food diary demonstrating a dietary calcium-to-protein ratio (in milligrams:grams) that does not exceed 13. the outcome variable is the change in bmd at hip, total body, forearm, and spine. treatment lasts for 3 years. we expect that bone mass will increase in both groups but will increase to a greater extent in the calcium-supplemented group than in the nonsupplemented group.

Eligibility criteria:
inclusion criteria: * women in good health * dietary calcium-to-protein ratio (in mg:g, as assessed by 7-day food diary) does not exceed 13 exclusion criteria: * smoking * pregnancy * lactation * endocrine disease

Keywords: calcium deficiency dietary calcium dietary protein osteoporosis calcium supplement bone density bone mass bone mass accumulation
lymphatic and systemic immunity changes in post-radiation lymphedema development

Conditions: Lymphedema

Summary: the goal of this study is to find out which immune molecules, cells, and genes are involved in the development of lymphedema (le), so that medicines that target them can be considered for treating lymphedema. the hypothesis is that le is a systemic, autoimmune-like disease that is initiated by inflammatory cytokines induced by surgery, radiation, and possibly chemotherapy in genetically susceptible patients.


Eligibility criteria:
inclusion criteria: * participants must be at least 18 years of age * participants must have been clinically diagnosed with breast cancer and scheduled for axillary lymph node dissection (alnd) and radiation treatment at md anderson (receiving chemotherapy, mastectomy or breast-conserving surgery, alnd (\>10 nodes) and radiation treatment for breast cancer, identified by drs. mittendorf and shaitelman of the nellie b. connally breast cancer center at md anderson) * ambulatory and possessing all four limbs * no prior radiation therapy * negative urine pregnancy test within 36 hours prior to study drug administration, if of childbearing potential * females participants must complete the female enrollment form. childbearing potential participants must agree to use one of the medically accepted forms of contraception for a period of one month after study participation. female participants who meet the criteria for non-childbearing will still complete the female enrollment form, but are not restricted to the use of contraception following study participation. exclusion criteria: * participants with a known or suspected allergy to iodine * participants who are breastfeeding, pregnant or trying to become pregnant * severe underlying chronic illness or disease (other than breast cancer) * participants not capable of keeping moderately still for the imaging portion of the study session (\~1 hour for imaging)