Kornimate/medical-research-clean huggingface dataset:
exercise-based cardiac rehabilitation for atrial fibrillation

Conditions: Atrial Fibrillation

Summary: the investigators aim to conduct a pilot randomised controlled trial (rct) with embedded feasibility study to evaluate an exercise-based cardiac rehabilitation (excr) programme when delivered to patients with atrial fibrillation on the waiting list for catheter ablation. our overall objective is to test the feasibility and acceptability of an evidence-based excr intervention prior to evaluation in a future randomized controlled trial (rct).

a two-arm pilot randomised feasibility trial (rct) with embedded process evaluation will be undertaken as a phased programme of work. patients on a waiting list for catheter ablation will be offered a referral to cardiac rehabilitation. the intervention consists of supervised exercise sessions run by a clinical exercise physiologist and psychoeducation sessions. the trial will involve one national health service (nhs) research site, liverpool heart and chest nhs foundation trust enrolling patients (n=60) to assess intervention and study design processes. primary outcomes are recruitment rate, adherence to the excr and loss to follow-up. semi-structured interviews and focus groups with patients and clinicians will be used to gather data on the acceptability of the intervention and study procedures. secondary outcome measures will be taken at baseline (preintervention), postintervention and at 6 month follow-up for both phases and will consist of exercise capacity measured by af burden, af recurrence, quality of life, exercise capacity, and cardiac structure and function.

Eligibility criteria:
inclusion criteria: * participant is willing and able to give informed consent for participation in the study. * aged ≥18 years. * diagnosed with af and on a waiting list or referred for medical treatment for symptomatic af (eg catheter ablation). * is eligible and willing to take part in an excr programme. exclusion criteria: * blood pressure \>180/100. * unstable angina. * severe valvular heart disease as diagnosed by echocardiography. * heart failure new york heart association (nyha) class 4. * \<6 months post-transplant. * resting/uncontrolled tachycardia. * stroke in last 6 weeks. * cardiac sarcoidosis. * injury or disability preventing exercise. * inability to understand trial procedures e.g. difficulties with speaking and understanding the english language.
rectus sheath block in cardiac surgery

Conditions: Cardiac Disease; Postoperative Pain

Summary: this is a prospective, randomized study. the purpose of this study is to evaluate the effect of post-surgical pain control of a type of peripheral nerve block, rectus sheath block. 1. does the rectus sheath block decrease opioid consumption postoperatively after cardiac surgery? 2. does the rectus sheath block decrease vas pain scores postoperatively after cardiac surgery? study participants will be assigned to receive either rectus sheath block or no block.


Eligibility criteria:
inclusion criteria: * in order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. adults 18-85 years old 2. scheduled to undergo cardiac procedures involving chest tubes 3. male or female exclusion criteria: * an individual who meets any of the following criteria will be excluded from participation in this study: 1. asa class v 2. urgent or emergent surgery 3. contraindications to administration of local anesthesia (e.g. local anesthetic allergy) 4. history of substance abuse or chronic opioid use 5. patient refusal or inability to consent

Keywords: cardiac surgery regional anesthesia
genome-wide association study of development of collateral circulation for patients with coronary or peripheral artery disease

Conditions: Coronary Disease; Peripheral Arterial Disease; Collateral Circulation, Any Site

Summary: the purpose of this study is to evaluate the genome-wide association for the development of collateral circulation for patients with coronary or peripheral artery disease and to develop the molecular genetic treatment model based on genome-wide association data.


Eligibility criteria:
inclusion criteria: * age more than 20 * chronic total occlusive lesion from the coronary or peripheral angiogram exclusion criteria: * renal dysfunction * hepatic dysfunction * thrombocythemia or thrombocythemia * planned major surgery in 1 year * history of gastrointestinal haemorrhage * malignant tumor

Keywords: genome-wide association collateral circulation
airway inflammatory profile among cleaning workers from different workplaces

Conditions: Inflammation; Work Related Illnesses; Symptoms and Signs; Asthma, Occupational; Rhinitis

Summary: there are consistent evidences through epidemiologic studies in different places, reinforced by occupational asthma records studies, that cleaning workers have a high risk in developing asthma. these risk determinants are not totally known. the air around the worker may have some higher and lower molecular weight with different concentration peaks from removed dust of the cleaning process and volatile substances from cleaning products. cleaning activities may occur in different places. although the relationship between rhinitis and asthma is already established, there are not many studies about occupational rhinitis-related work place. this study aimed to investigate airway inflammation and respiratory symptoms of cleaning workers from different workplaces.

were recruited to participate in the study individuals from four different workplaces: hospital; university; housekeeper and control (office workers). the research was performed in cacoal city, rondonia, brazil. smokers (active), pregnant, lactating, and individuals at continuing therapy for treating disorders of the airways were excluded. clinical profile and respiratory symptoms employees evaluation were performed using the european community respiratory health survey for occupational diseases evaluation (ecrhs), and the international study of asthma and allergies in childhood (isaac) - asthma module. nasal swab was collected for evaluation of upper airways inflammation, according to ronchetti et al protocol, using a sterile swab that was moistened with 1ml saline solution; both nostrils were scraped using this swab. twenty minutes after this, laminas were stained using may-grunwald-giemsa to eosinophils, neutrophils, lymphocytes, macrophages and epithelial cells identification. cells were analyzed using a nikon e600 optical microscope (nikon, canada), of 1.000 x magnitude. whenever possible a total of 200 cells were counted in two slides. statistical analysis were performed using anova variance (kruskal-wallis) and dunn's test for comparisons between groups. to evaluate the association between the qualitative variables we used the chi-square, statistical software sigma plot 12.0 and spss 21.0. the confidence interval was 95% (p \<0.05).

Eligibility criteria:
inclusion criteria: * cleaning workers from different workplaces * non-cleaning workers (control group) * people legally capable (over 18 years old) * must be able to nasal swab collection and answer questionnaires * sign the informed consent form exclusion criteria: * smokers (active) * pregnant (women) * lactating (women) * not accept the informed consent form * individuals at continuing therapy for airways treating disorders

Keywords: cleaning workers work-related asthma work-related rhinitis respiratory symptoms nasal swab
effects of whole-body vibration and high impact exercises in postmenopausal women

Conditions: Osteoporosis, Postmenopausal; Exercise Therapy

Summary: we investigated the effects of whole body vibration (wbv) and high-impact (hi) exercises in postmenopausal women with low bone mineral density. in summary, wbv exercises are effective in preventing bone loss and wbv and hi exercise programs are effective in decreasing fall risk, increasing health-related quality of life and improving depressive symptoms

purpose: the aim of this study was to determine the effects of six months of supervised whole-body vibration (wbv) and high-impact (hi) exercises on bone mineral density (bmd), serum bone turnover markers, fall risk, health-related quality of life (hrqol) and depressive symptoms in postmenopausal women, additionally, to evaluate the advantage of each training program to another. methods: in a prospective, randomized controlled 6-month interventional trial 58 eligible postmenopausal women were assigned to wbv training group (n=19), hi training group (n=19), or control group (n=20). the patients in both training groups participated in a supervised training program, which consisted of the one-hour exercise session three times a week for six months. the wbv groups received vibration (30-35 hz, 2-4 mm) in five different static positions. the hi group jumped rope (10-50 jumps/day). all patients received calcium (1000 mg) and vitamin d (880 iu) supplementation per day. in all participants, baseline and six-month bmd at the lumbar spine and femur were measured by dual-energy x-ray absorptiometry (dxa). serum osteocalcin (oc) and c-terminal telopeptide of type i collagen (ctx) were measured at baseline, three- and six-month intervals. fall risk was assessed by using the timed up and go (tug) test and fall index measured by static posturography at baseline, three- and six-month intervals. hrqol and depressive symptoms were assessed using the quality of life questionnaire of the european foundation for osteoporosis (qualeffo) and beck depression inventory (bdi), respectively, at baseline and six-month of the study.

Eligibility criteria:
inclusion criteria: * postmenopausal women aged 40-65 years old * bone mineral density t-scores between -2.0 and -3.0 at the l1-l4, l2-l4, femoral neck, trochanter and/or total hip regions * serum 25(oh)vitamin d level ≥ 30 ng/ml. exclusion criteria: * the use of any medications and/or disease that affect bone metabolism * neuromuscular performance, and/or balance; presence of cardiovascular, pulmonary, neuromuscular, and/or chronic diseases that affect exercise training * presence of an osteoporotic fracture * presence of a musculoskeletal disease, such as an acute lumbar herniated disc and/or spondylolisthesis * presence of gall or kidney stones, prostheses, intraocular lenses, and/or implants * body mass index ≥35 kg/m² * thrombosis history
three different laparoscopic approaches for ovarian endometrioma and the effect on ovarian reserve

Conditions: Endometriosis

Summary: is ovarian reserve and fecundity rate higher with laparoscopic ovarian aspiration rather than laparoscopic ovarian cystectomy and laparoscopic ovarian de-roofing in infertile woman with ovarian endometrioma or not?

primary objective: to assess antral follicular count before and after treatment of endometriotic cyst either by aspiration, stripping, de-roofing and bed cauterization. secondary objectives to assess anti mullerian hormone level, follicle stimulating hormone level ,doppler blood flow before and after treatment of endometriotic cyst either by aspiration, stripping, de-roofing and bed cauterization.

Eligibility criteria:
inclusion criteria: * infertile woman aged 18-35 years old. * endometriotic ovarian cyst with size less than or equal 5 cm. exclusion criteria: * other than included criteria.
multisensory early oral administration of human milk in preterm infants

Conditions: Infant Development; Stress

Summary: more than 60,000 infants are born between 22 to 32 weeks gestation age annually in the us. approximately 11% of them develop comorbidities. during nicu hospitalization, preterm infants inevitably endure early life toxic stress without adequate protective buffers. early life toxic stress results in adverse epigenetic modifications of glucocorticoid-related genes and dysbiosis, impairing neurodevelopment. these adversities further exacerbate the risk of comorbidities and inappropriate brain development during sensitive periods of neuroplasticity. adverse epigenetic modifications and dysbiosis may set a life-long trajectory of risk for chronic health conditions. it is a clinical and scientific priority to test an early nicu intervention to attenuate stress-related adverse epigenetic modifications and dysbiosis. human milk influences the structure and relative abundance of healthy gut bacteria and neurodevelopment. maternal nurturing, e.g., licking and grooming (in rodents), and breastfeeding and touch (in humans), promotes neurodevelopment, reduces stress, and reverses stress-related epigenetic modifications. the multisensory early oral administration of human milk (m-milk) intervention is designed to provide an enjoyable and nurturing experience for infants, through a safe and consistent infant-guided provision of human milk droplets, given orally as early as 22 weeks postmenstrual age. m-milk is implemented from day 3 of life, after every hands-on care, and during the beginning of a full gavage feeding. we propose the m-milk pilot randomized controlled trial (rct): a 2-group (n = 12, 6 per group), parallel, and longitudinal design in preterm infants who are born between 22 to 28 weeks gestational age. the aims of this pilot are to determine the feasibility and acceptability of the m-milk intervention, recruitment, retention, and obtain data for sample size estimation. this study will advance nursing science and practice because it will inform our r01 rct to examine the efficacy of m-milk to attenuate adverse effects of early life toxic stress in preterm infants.


Eligibility criteria:
inclusion criteria: * born between 22 to 28 weeks gestational age and receiving mother's own milk and/or donor milk. exclusion criteria: * receiving only formula, oral cavity defects, gastrointestinal defects, chromosomal abnormalities, severe cardiac defects that require surgery, or intraventricular hemorrhage grade iii or iv

Keywords: stress preterm infants epigenetics gut microbiome parent-infant relationship
effect of remote ischaemic preconditioning on renal function in patients undergoing living donor kidney transplantation

Conditions: Kidney Diseases; Kidney Failure, Chronic; Kidney Failure; Renal Insufficiency; Renal Insufficiency, Chronic; Urologic Diseases

Summary: the purpose of this study was to investigate whether lower limb ischaemic preconditioning can improve renal function in patients undergoing living donor kidney transplantation

ischemia reperfusion injury (iri) induced renal failure after kidney transplantation is a common clinical problem associated with a high morbidity and mortality. to reduce the adverse effects of iri after organ transplantation various strategies aimed at the different pathophysiological processes of iri have been investigated. remote ischemic preconditioning (ripc) is one such strategy where brief iri of one organ protects other organs from sustained iri. many studies have shown that ripc protects heart, muscle flaps, stomach, liver, lungs, and kidneys from iri. ripc of the limb with a tourniquet is a safe and convenient method of preconditioning organs against iri. however, the efficacy of ripc in patients undergoing living donor kidney transplantation need to be established and mechanism of early and late ripc, such as whether the donor should undergo remote preconditioning or the recipient, need to be investigated.

Eligibility criteria:
inclusion criteria: * subject capable of giving written informed consent, with end-stage kidney disease, who is a suitable candidate for primary kidney transplantation * living donors * compatible abo blood type * pra \< 20% exclusion criteria: * re-transplant patients * those with peripheral vascular disease affecting the lower limbs

Keywords: remote ischaemic preconditioning kidney transplantation
long term follow up on functional gastrointestinal disorder (fgid)

Conditions: Functional Gastrointestinal Disorder

Summary: long term prognosis and risk factors in functional gastrointestinal disorder (fgid) is largely unknown. the investigators plan to retrospectively analyse a cohort of children who were referred to the pediatric clinic due to abdominal pain with the aims to learn more about symptoms and effects of investigations performed. furthermore, the investigators plan to contact the cases for a follow up using a validated questionnaire and analyse the long term prognosis and risk factors for prolonged severe symptoms.

long term prognosis and risk factors in functional gastrointestinal disorder (fgid) is largely unknown. the investigators plan to retrospectively analyse a cohort of children who during the years 2010-2015 were referred to the pediatric clinic of umeå university hospital due to abdominal pain. the aims are to explore and descriptively describe the symptoms and effects of investigations performed. furthermore, the investigators plan to contact the cases five years after the first contact for a follow up using a validated questionnaire of the rome-iii-criteria and analyse the long term prognosis and risk factors for prolonged severe symptoms.

Eligibility criteria:
at time of first visit the children had: 1. at least 2 months of abdominal pain 2. age 3-18 years 3. no organic gastrointestinal diseases 4. no neuromuscular disease
the natural history of wheat hypersensitivity in thai children

Conditions: Wheat Allergy; Child

Summary: wheat allergy is affected 0.4-1% and is a major staple of the worldwide diet. wheat avoidance is exceedingly difficult and imposes major dietary restriction. the purpose of this study were to determine the rate of oral tolerance and identify clinical and laboratory predictors of tolerance development in thai children who allergic to wheat.

all children in this study were sensitized to wheat. each patient was clinically evaluated, with focus on wheat allergy by both a detailed medical examination and collection of medical history. blood sample was taken for baseline determination of immunoglobuline antibodies to wheat and to omega-5-gliadin. the oral wheat challenge were performed in all study subjects to identify a case of wheat outgrowing. the primary outcome was the development of oral tolerance to wheat. oral wheat challenge were generally performed at least every 1 years if the child did not have an interval history of symptoms with unintentional exposure.

Eligibility criteria:
inclusion criteria: * children 1 to 15 years * history of ige-mediated wheat allergy exclusion criteria: * parents refused to sign the consent * patient has the underlying disease: congenital heart disease, uncontrolled asthma or life-threatening condition.

Keywords: wheat allergy wheat outgrowing wheat hypersensitivity omega-5-gliadin natural history of wheat hypersensitivity
identification of large-scale mutations of polg gene by qmpsf in patients with mitochondrial dna instability.

Conditions: Mitochondrial Diseases; Diagnosis; DNA Mutations

Summary: mitochondrial diseases are a heterogeneous group caused by genetic defects in mitochondrial dna or in nuclear genes. polg is the most frequently involved gene in mtdna instability diseases resulting in mtdna multiple deletion and/or depletion. it encodes the dna polymerase gamma (polγ), the only known dna polymerase found in mammalian mitochondria. mutations in polg could explain 45% of familial progressive external ophtalmoplegia associated with multiple mtdna deletions. however, in more than 70%, the analysis of the genes involved in mtdna instability remains unsuccessful. to date, these genes are screened by sequencing methods that are not able to detect large-scale rearrangements. in order to detect possible large-scale rearrangements, the investigators propose to develop a new assay based on qmpsf (quantitative multiplex pcr of short fluorescent fragments) able to detect exon deletions and duplications. the investigators propose to screen the polg gene by qmpsf in at least twenty patients with either no mutation or only one mutation detected in polg and no mutation in other genes such as twinkle and ant1. this study would allow the investigators to know if large-scale rearrangements occur in the polg gene and to estimate their frequency in patients with mtdna instability. these data are important to know if the sequencing analysis of polg should be completed by the screening for partial deletions and duplications to ensure an accurate molecular diagnosis of these syndromes. moreover, this method could be extended to ant1 and twinkle genes.


Eligibility criteria:
inclusion criteria: * patients already diagnosed for mitochondrial pathology without mtdna mutations yet detected by current diagnostic techniques
study of secukinumab in patients with newly-diagnosed type 1 diabetes mellitus

Conditions: Type 1 Diabetes Mellitus

Summary: this study will assess the safety and efficacy of secukinumab on the preservation of pancreatic beta cells in patients with newly-diagnosed type 1 diabetes mellitus.


Eligibility criteria:
inclusion criteria: males and females aged 18-35 years initially (subjects aged 8-17 may be included at a later stage, starting with age 12-17 years, followed by age 8-11 years). body weight between 40-120 kg initially (subjects weighing 21-39 kg may be included at a later stage). recent onset type 1 diabetes mellitus, diagnosed with 100 days of first dose. peak stimulated c-peptide levels \>/= 0.2 pmol/l following mixed meal tolerance test exclusion criteria: any form of diabetes other than auto-immune type 1 (eg, type 2 diabetes, maturity onset diabetes of the young, latent autoimmune diabetes of the adult). diabetic ketoacidosis within 2 weeks of screening. pregnancy or lactation. recent (within 2 weeks of screening), ongoing, chronic or recurrent infectious disease. active infection with hepatitis b or c, epstein-barr virus, cytomegalovirus, or hiv. tuberculosis infection. other protocol-defined inclusion/exclusion criteria may apply

Keywords: type 1 diabetes mellitus
effectiveness of yiqi fumai lyophilized injection for acute heart failure

Conditions: Acute Heart Failure; Complementary Medicine; Chinese Medicine

Summary: the goal of this cohort study is to observe the effectiveness of yiqi fumai lyophilized injection (yqfm) in patients with acute heart failure (ahf). it mainly aims to assess the effectiveness of yqfm on the 90-day mortality or readmission rate in patients with ahf and compare the results with august-ahf rct study. there will be no intervention, but information will be collected during the hospital stay and during the follow-up period of 180 days . researchers will compare exposed group(patients who received yqfm) and non-exposed group(patients who didn't received yqfm) to see if there is difference on the 90-day mortality or readmission rate.

it mainly aims to assess the effectiveness of yqfm on the 90-day mortality or readmission rate in patients with ahf and compare the results with august-ahf rct study. there will be no intervention, but patients will be asked to answer questions(such as scales or reporting of symptoms ) and provide biochemical or imaging tests, as well as undergo regular follow-up. researchers will compare exposed group(patients who received yqfm) and non-exposed group(patients who didn't received yqfm) to see if there is difference on the 90-day mortality or readmission rate. we will also collect information on medication adherence during the follow-up period and remotely test patients during the follow-up period

Eligibility criteria:
inclusion criteria: * diagnosis of ahf * age≥18 years * voluntarily participate in and sign the informed consent form exclusion criteria: * with major psychiatric disorders or unable to complete follow-up assessment * known allergies to drugs or drug ingredients * patients enrolled in other trials within 1 month