Kornimate/medical-research-clean huggingface dataset:
a prospective observational study about adjuvant or neoadjuvant chemotherapy related adverse effects in postmenopausal breast cancer patients

Conditions: Breast Cancer

Summary: breast cancer is one of the most common malignant tumor in women. about 69.75% of breast cancer women patients in china are over 45 years old. it is a multicenter prospective observational study. we collect the basic information, medical history, chemotherapy-related adverse reactions, and the results of blood lipid and bone density test before, during and after adjuvant or neoadjuvant chemotherapy. the purpose of the study is to investigate the risk factors for hyperlipidemia, cardiovascular disease, and osteoporosis in postmenopausal breast cancer patients before and after chemotherapy, and to assess the risk of future arteriosclerotic cardiovascular disease and osteoporotic fractures. in addition, the collected information of the subjects are analyzed to provide suggestions for the relevant prevention strategy.

breast cancer is one of the most common malignant tumor in women. about 69.75% of breast cancer women patients in china are over 45 years old. chemotherapy is one of the important treatments for breast cancer, but it brings a series of adverse effects, especially increasing the risk of hyperlipidemia, cardiovascular disease and osteoporosis in postmenopausal women. it is a multicenter prospective observational study. the postmenopausal breast cancer women patients who are planning adjuvant or neoadjuvant chemotherapy are enrolled in the study after signing the informed consent form and passing the screening. we collect the basic information, medical history, chemotherapy-related adverse reactions, and the results of blood lipid and bone density test before, during and after chemotherapy. the purpose of the study is to investigate the risk factors for hyperlipidemia, cardiovascular disease, and osteoporosis in postmenopausal breast cancer patients before and after chemotherapy, and to assess the risk of future arteriosclerotic cardiovascular disease and osteoporotic fractures in this population.in addition, the collected information of the subjects are analyzed to provide suggestions for the relevant prevention strategy.

Eligibility criteria:
inclusion criteria: 1. informed consent form has been signed. 2. breast cancer patients whose age is ≥ 18 years old and have been diagnosed by histological examination. 3. postmenopausal women who are defined by any of the following: * previous bilateral oophorectomy; * age ≥ 60 years old; * age \<60 years old, menopause at least 12 months, and follicle stimulating hormone \[fsh\] and estradiol levels in the postmenopausal range. 4. plan for adjuvant or neoadjuvant chemotherapy. exclusion criteria: 1. those who have already received adjuvant or neoadjuvant chemotherapy. 2. those who have chemotherapy contraindications. 3. those who have any mental condition that prevents the understanding of the contents of this study and can't provide the complete information required.
enhancing hiv prevention by using behavioral intervention among hiv-infected men

Conditions: HIV Infections

Summary: this study will evaluate the effectiveness of a behavioral intervention program versus standard prevention case management in promoting safer sex practices in hiv-infected men.

in recent years, the spread of hiv and other stds has increased, especially among men who have sex with men. this increase signifies continued sexual risk taking within this population. in order to curb the increase of hiv infections, prevention programs are needed. a standard prevention case management program has been developed; however, new programs that further improve outcomes are needed. this study will evaluate the effectiveness of a behavioral intervention program versus standard prevention case management (pcm) in promoting safer sex practices in hiv-infected men. participants in this 1-year open-label study will be randomly assigned to receive either pcm alone or a behavioral intervention called project enhance, in addition to pcm. the behavioral intervention will be administered by a trained medical social worker on an individual basis. it will include an education component, as well as motivational and behavioral skills enhancement. pcm will entail standard case management, as well as referrals to specific services that each individual may need. treatment will occur for only the first 3 months, after which follow-up sessions will be held every 3 months for the remainder of the year.

Eligibility criteria:
inclusion criteria: * hiv infected * receives primary health care at fenway community health * identifies as a man who has sex with men * has engaged in unprotected anal or vaginal intercourse within 3 months of study enrollment exclusion criteria: * all episodes of unprotected anal intercourse occurred with only a single primary partner who is also hiv infected * plans to relocate over the upcoming year

Keywords: hiv msm
led therapy for the treatment of concussive brain injury

Conditions: Brain Concussion

Summary: a double blind randomized trial of light-emitting diode (led) therapy for patients suffering from mild traumatic brain injury (mtbi). patients seen in the sports concussion clinic with cognitive symptoms lasting for greater than 4 weeks will be randomized to either placebo therapy (controls) or treatment with led therapy (cases). both cases and controls would complete post-concussion symptom scales delis-kaplan executive function system (d-kefs), and impact studies on entry into the study and at weeks 3 and 6, or earlier if their symptoms resolve before the end of the 6 week period.

concussion, also known as mild traumatic brain injury (mtbi), results from a rotational acceleration of the brain. the biomechanical forces which cause concussion lead to the opening of ion channels within the neuronal cell membranes, allowing for a massive influx of sodium and efflux of potassium. this results in a spreading depression type of phenomenon, leading to the depolarization of neurons diffusely throughout the brain.19 in order to restore the homeostatic ion gradients across the membrane, the sodium-potassium pumps require increasing amounts of adenosine triphosphate (atp). thus, there is an increased need for atp after concussion. atp is supplied by the glycolysis of glucose from the blood stream. both experimental models of concussion and human studies, however, show decreased cerebral blood flow after the initial response to injury. thus, there is an increased demand for atp after concussion; but a diminished supply of glucose to meet the demand. the absorption of light in the red/near infrared wavelength spectrum by cytochrome c oxidase increases atp synthesis. thus, by increasing atp synthesis, red/near infrared leds can treat the underlying pathophysiological cause of concussion symptoms. if successful, this would be the first therapy to directly treat the underlying pathophysiology of concussion.

Eligibility criteria:
inclusion criteria: * patients 11 years old or greater * diagnosed with a concussion whose symptoms have persisted for more than 4 weeks * total score on the cognitive components of the post-concussion symptom scale exceeds 9, or if they have a composite score on any one of the 4 main outputs of the computerized neurocognitive assessment: immediate post-concussion assessment and cognitive testing (impact) that is below the 90th percentile for their age. exclusion criteria: * clinically indicated imaging has been obtained where a hemorrhage is demonstrated * being considered for an alternate diagnosis (other than concussion) * have a pre-injury diagnosis of any of the following: depression, post-traumatic stress disorder, other psychiatric disorder * taking any of the following medications: amantadine, , amphetamine, atomoxetine

Keywords: concussion mild traumatic brain injury mtbi led light emitting diode headache brain concussion
insulin sensitivity, impaired counterregulation, and glucose variability

Conditions: Type 1 Diabetes Mellitus

Summary: this protocol will investigate physiological parameters including insulin sensitivity and counterregulatory function using a mixed meal test and induced hypoglycemia in subjects with type i diabetes.

the principal idea of the proposed research is: in order to be successful, closed-loop control of glucose in diabetes must adapt to individual physiologic characteristics and to the behavioral profile of each person. we propose to build a system that will use observers of patients' behavior and metabolic state and control modules that are responsible for insulin delivery and hypoglycemia prevention. in this phase of the project, we will investigate relationships of insulin sensitivity and impaired counterregulation with blood glucose variability, aiming to develop algorithmic physiology observers, which will track specific parameters of glucose variability and recurrent hypoglycemia as markers of change in a person's insulin sensitivity and counterregulatory ability.

Eligibility criteria:
inclusion criteria: * type i diabetes mellitus (tidm) (as defined by the american diabetes association criteria or judgment of a physician) for at least two years prior to the enrollment in the study. * use of an insulin pump to treat their diabetes for at least six months prior to the study. * ability to use a bolus calculator function with the current insulin pump with pre-defined parameters for glucose goal, carbohydrate ratio, and insulin sensitivity factor. * age 21 - 64 years. adults age 65 and over are likely to have medical exclusions for the follow-up phase 2 study, which involves induced hypoglycemia. * completed phase 1 of the institutional review board (irb) #14956 "development of a behavioral observer for type 1 diabetes mellitus" * willingness to use lispro (humalog) insulin two days prior to and during inpatient admission. * willingness to perform self-monitoring blood glucose (smbg) 4 times per day at times before meals and bedtime. * demonstration of proper mental status and cognition for completion of the study. exclusion criteria: * pregnancy * psychiatric disorders that would interfere with study tasks (e.g. mental retardation, substance abuse) * history of a systemic deep tissue infection with methicillin-resistant staph aureus or candida albicans * known bleeding diathesis or dyscrasia * active enrollment in another clinical trial * medical condition that would make operating an insulin pump difficult (e.g. blindness, severe arthritis, extensive scar tissue at sites where devices are inserted). * anemia (hematocrit \<36% \[females\], \<38% \[males\]), * allergy or adverse reaction to lispro (humalog) insulin * conditions which may increase the risk of induced hypoglycemia such as symptomatic heart disease, congestive heart failure, history of a cerebrovascular event, atrial fibrillation, renal insufficiency (creatinine \>1.5) or uncontrolled hypertension (resting blood pressure \>140/90).

Keywords: type 1 diabetes mellitus
autologous human umbilical cord tissue patch for postnatal closure of open neural tube defects

Conditions: Spina Bifida

Summary: the purpose of this study is to determine the impact of an autologous umbilical cord patch for dural closure on the repair of open neural tube defect. the outcomes will evaluate successful defect closure, creation of a more capacious spinal canal, and reduction in inflammatory tissue response versus historical controls.


Eligibility criteria:
inclusion criteria: * neonates born with prenatal diagnosis of open neural tube defect (myelomeningocele or myeloschisis) * resident of the united states * provision of signed and dated informed consent form * stated willingness by legally authorized representative (lar) to comply with all study procedures and availability for the duration of the study * maternal age 18 years and older * mother is english or spanish speaking exclusion criteria: * sepsis or signs of infection of the neonate * febrile or other acute illness of the neonate at time of delivery * major congenital anomaly unrelated to spina bifida that may impact safety of neonate for surgery * evidence of intra-amniotic or maternal infection related to pregnancy at time of delivery * maternal use of steroid therapy during pregnancy or neonate use of steroid therapy,except for lung maturity indications * vaginal delivery * patch closure of dura is deemed unnecessary * umbilical cord abnormality * insufficient autologous cord tissue or patch * autologous umbilical cord patch that does not meet laboratory safety standards per standard operating procedure (sop) * treatment with an investigational drug or other intervention that would influence morbidity or mortality

Keywords: open neural tube defects autologous umbilical cord patch myelomeningocele myeloschisis
kinesio taping and manual therapy efficacity on lumbar pain during pregnancy

Conditions: Manual Therapy

Summary: pregnant women often suffer from lumbar pain , specially during the last semester . usually physiotherapy and manual therapy on trigger point help them . but there is also another type of support , the kinesio-taping using the pose of a strip which aims to mobilize the muscle without any restriction. the purpose is to reduce the pain with the combo therapy (trigger point plus kinesi taping)


Eligibility criteria:
inclusion criteria: * age \> 18 * french speaking * single pregnancy * lumbar pain * eifel score\>6 * medical insurance exclusion criteria: * twins pregnancy * rachial arthrodesis * probable acrylique allergy * psoriasis or other cutaneous problems * circulatory disorder

Keywords: lumbar pain; pregnancy;
gestational diabetes mellitus and cardiometabolic syndrome in offspring

Conditions: Gestational Diabetes Mellitus

Summary: gestational diabetes mellitus (gdm) has long been known as leading to macrosomias, neonatal hypoglycemias and other complications which are treatable and preventable. nowadays, gdm is recognized as an entity with long-term serious sequels to the mother (gdm is considered a forerunner of type 2 diabetes) and her offspring. indeed, according to the programming hypothesis, gdm sets the stage for metabolic syndrome, obesity, type 2 diabetes and hypertension. however, these cross-sectional studies failed to control for maternal disease history and genetic background although heredity is a major epidemiology risk factor of type 2 diabetes. also, studies usually refer to traditional markers such as bmi, blood pressure, lipids profile and oral glucose tolerance test (ogtt); none explored inflammatory biomarkers and adipokines in-depth, despite the possible link between their presence and the development of metabolic and cardiovascular diseases in gdm offsprings. exclusion of genetic confounding factors will help establish the role of gdm as an independent marker of cardiometabolic risk in gdm offspring. it is highly relevant to identify gdm as a risk factor for cardiometabolic diseases, given the worldwide obesity epidemic, the alarming prevalence increase of gdm and its serious sequels to both mother and offspring.


Eligibility criteria:
inclusion criteria: * age 4 to 12 years * tanner stage \< 2 * to understand french or english exclusion criteria: * type 1 diabetes * weight \< 10 kg * placenta abnormalities * gestational age \< 34 weeks * illness affecting growth and metabolism * taking medications
group psychotherapy in long covid

Conditions: Long COVID; COVID-19

Summary: the aim of the present study was to establish a single-arm group psychotherapy and to evaluate its clinical effectiveness in long covid patients.

this study took place at the cantonal hospital st.gallen, a tertiary care hospital in eastern switzerland, and included data collection between november 2021 and january 2024. during this time span, the same licensed psychotherapist conducted the group psychotherapy six times in total with a maximum of nine patients each. each of the six groups had one-hour group therapy sessions weekly within eight consecutive weeks. during the study period, the group psychotherapy was part of a more comprehensive treatment for long covid as all patients primarily received active pacing therapy. the investigators implemented cognitive-behavioral therapy (cbt) and acceptance and commitment therapy (act) elements into group psychotherapy and focused on fatigue, insomnia, depression, anxiety, somatic symptoms, psychotraumatology, and quality of life as psychosomatic outcome measures (pre- and post-interventional).

Eligibility criteria:
inclusion criteria: * signed general consent form of the cantonal hospital of st.gallen * adult patients (≥ 18 years of age) * long covid diagnosis made as part of the long covid consultation at the cantonal hospital of st.gallen * screening for psychological stress and suitability for group therapy through an initial consultation with a psychotherapeutic specialist from the department of psychosomatic medicine and consultation-liaison psychiatry at the cantonal hospital of st.gallen exclusion criteria: * insufficient language skills for completing the questionnaires in german * refusal to sign the general consent form * severe mental disorders requiring an individualized setting, i.e. suicidal tendencies at the time of screening, acute psychosis and personality disorder

Keywords: covid-19 long covid long covid-19 syndrome group psychotherapy cognitive behavioral therapy cbt acceptance and commitment therapy act psychometrics
double-balloon colonoscopy to increase colonoscopy completion rate

Conditions: Colorectal Cancer; Colorectal Adenomas; Inflammatory Bowel Disease

Summary: the aim of colonoscopy is to visualize the inside of the entire large bowel. several factors can make the procedure difficult, and sometimes a complete examination is not possible. complicating factors include poor bowel preparation and technical challenges such as differences in anatomy (long, redundant colonic segments), post-surgical adhesions, strictures and diverticulosis. a special endoscope with two inflatable balloons, originally designed to examine the small bowel, has been used for several years with success in such technically difficult colonoscopies. more recently a modified double-balloon instrument was designed specifically for colonoscopy, but the documentation of the performance of this instrument is limited. the aim of the present study is to investigate the performance of the double-balloon colonoscope in cases where conventional colonoscopy have failed due to technical difficulties.

this is a prospective cohort study to investigate the performance of the test instrument. the test instrument consists of a slim, flexible colonoscope with an overtube and an inflatable balloon on the tip of the colonoscope and the tip of the overtube. patients are eligible for inclusion if conventional colonoscopy fails due to technical difficulties such as loop formation, long colonic segments or suspected adhesions. written informed consent is required. the study procedures will be performed immediately after the failed conventional colonoscopy, or on a rescheduled appointment within four weeks.

Eligibility criteria:
inclusion criteria: * failed cecal intubation during conventional colonoscopy due to technical difficulties exclusion criteria: * failed cecal intubation due to insufficient bowel preparation * stenotic colonic lesions * patients decline * pregnancy * persons younger than 18 years * persons unable to comprehend the information given

Keywords: colonoscopy colorectal cancer screening colonoscopy
effects of genmont probiotic on improve the level of blood glucose and other diabetic associate parameter in type 2 diabetes patients

Conditions: Type 2 Diabetes

Summary: the purpose of this study is to evaluate the efficacy and safety of probiotics adr-1/gmnl-263 capsules (lactobacillus reuteri adr-1/ lactobacillus reuteri gmnl-263) for the treatment of adults with type2 dm.

background：based on animal studies, intake of probiotic bacteria was suggested to improve insulin sensitivity by reducing inflammation. objective ： the objective of this study was to determine the effects of supplementation with the probiotic strain lactobacillus reuteri adr-1(adr-1) and lactobacillus reuteri gmnl-263 (gmnl-263) over six months on metabolic profiles, intestinal microbiota profiles and biomarkers of inflammation in type 2 diabetes patents. methods ： this randomized double-blind placebo-controlled clinical trial was performed on 120 diabetic patients. subjects were divided into 3 groups: 40 subjects in the group a received placebo, 40 subjects in the group b received adr-1 (4 x 109 colony-forming units/d), and 40 subjects in the group c received gmnl-263. (2 x 1010 cells/d) for 6 months. fasting blood samples were taken at baseline and after intervention to measure metabolic profiles and biomarkers of inflammation including c reactive protein (crp), interleukin 6 (il-6) and tumor necrosis factor-alpha( tnf-α). the intestinal microbiota profiles were detected in stool samples by real-time polymerase chain reaction (rt-pcr).

Eligibility criteria:
inclusion criteria: 1. type 2 diabetes with a duration\> 6 months 2. 7 % \< hba1c ≦ 10 % 3. adults 25- 70 years of age 4. bmi\>18.5 exclusion criteria: 1. pregnancy 2. subjects with any other serious diseases such as cancer (patient with benign tumor under medical control should not be ruled out), kidney failure / dialysis, heart disease, stroke. 3. autoimmune disease 4. administration of other healthy food for diabetes 4 weeks before inclusion 5. administration of probiotic 4 weeks before inclusion 6. administration of antibiotics 4 weeks before inclusion 7. participation in other clinical trials 8. alt/sgpt or ast/sgot \> 3x upper limit of normal (uln) 9. egfr\<30ml/min/1.73m2 10. subjects who is lack of physical integrity of gastrointestinal tract, or malabsorption syndrome, or inability to take oral medication.

Keywords: lactobacillus reuteri type 2 diabetes