Kornimate/medical-research-clean huggingface dataset:
a cohort study of patients treated with brachytherapy for selected desmoid patients in gardner syndrome

Conditions: Gardner Syndrome; Colorectal Carcinoma; Desmoid Tumor

Summary: the purpose of this study is to assess the long-term outcome in a cohort of gardner-syndrome patients receiving prophylaxis and treatment for intestinal and non-intestinal tumors.

since 1978, we have been following a family of 105 descendants with gardner syndrome (gs). mutation carriers were screened by endoscopy, and colorectal resection was performed upon pending malignancy. resectable desmoid tumors were excised, whereas large tumors of the abdominal wall were treated by a combination of brachytherapy (bt) and radiotherapy (rt). outcome was analyzed with respect to length of tumor-free survival, and morbidity from surgery or radiotherapy. results: 37 of 105 family members have gs. preventive colorectal resections were performed in 16 patients (15%), with one death due to subsequent gastric cancer. in 4 patients who denied screening endoscopy, invasive tumors of the colon (3 patients) and stomach (one patient each) developed. of 33 desmoid tumors, 10 (30%) were located in the mesentery, 17 (52%) in the abdominal wall, and 6 (18%) in extra-abdominal sites. excision of 12 desmoids was performed in 8 patients (36%), and 4 were treated by a combination of bt and rt. following bt/rt, all patients showed full or partial remission.

Eligibility criteria:
inclusion criteria: * family with an identical adenomatous polyposis coli (apc-) germ line mutation exclusion criteria: * negative testing for adenomatous polyposis coli (apc-) germ line mutation

Keywords: gardner syndrome colorectal carcinoma desmoid tumor resection colon
colloid osmotic pressure in patients with fontan circulation

Conditions: Heart Defects, Congenital

Summary: children born with univentricular heart will go through step surgery and end up with a fontan circulation. a circulation with cause problems with body fluid balance.this project will evaluate changes in interstitial colloid osmotic pressure in patients 10 year after completion of a three step fontan surgery. this project will evaluate whether increased micro vascular leakage and change in interstitial colloid osmotic pressure are present in patients after ten years with a fontan circulation.


Eligibility criteria:
inclusion criteria: * fontan circulation after completed fontan surgery. * anesthesia during catheterization. exclusion criteria: * no consent
vaginal progesterone 400mg v.s 200mg for prevention of preterm labor in twin pregnancies

Conditions: Twin Pregnancy With Antenatal Problem

Summary: it is already known that the risk of preterm labor in twin pregnancy before 37 week is 8-9 fold higher compared to singletons, and progesterone supplementation can decrease the incidence of preterm labor in singleton pregnancy. there were studies that used 200mg vaginal progesterone with no effect on the result so this study aims to examine the effect of prophylactic vaginal progesterone 400mg v.s 200mg for prevention of preterm birth in twin pregnancies


Eligibility criteria:
inclusion criteria: 1. primigravidae 2. twin pregnancies at gestational age 14 week. 3. cervical length more than 2 cm (because if 2cm or less they will undergo cervical cerclage.) exclusion criteria: * polyhydramnios * anemia * twins with congenital malformation * twin to twin transfusion * medical diseases as diabetes mellitus, hypertension and systemic lupus erythematosis * previous cervical surgery * high order pregnancy (triples or more)

Keywords: progesterone twin pregnancy preterm labor
randomized study for the assessment of silibinin (legalon® sil) in the treatment of naïve genotype 4 patients with chronic hepatitis c

Conditions: Hepatitis C, Chronic

Summary: the purpose of this study is to explore whether silibinin plus ribavirin with/without peg-interferon can be more effective than the peg-interferon plus ribavirin based standard of care (soc) in the treatment of patients infected with hepatitis c virus genotype 4.


Eligibility criteria:
inclusion criteria: * patient must be willing to give written informed consent * male and female patients; age between 21 and 45 years inclusive * chronic hepatitis c infection with genotype 4 confirmed by genotypic testing at screening or within 6 months of screening period * patients eligible to be treated with rbv and peg-ifn as per the instructions present in their prescribing information documents * no history of prior interferon therapy (treatment naïve) * detectable hcv-rna levels * normal bun and creatinine * ability to communicate, participate, and comply with the requirements of the entire study exclusion criteria: * liver transplant patients * co-infection with hiv and/or hbv * alt \>10-fold the upper limit of normal i.e. \> 400 u/l * evidence of hepatocellular carcinoma (hcc) * fibroscan® at screening with a score ≥ 14.5 kpa * evidence of liver disease due to causes other than chronic hcv infection * evidence of poorly controlled diabetes (defined as hba1c \> 8%) * history of alcohol or drug abuse within the last 12 months * history or clinical evidence of liver decompensation, e.g. presence of ascites or encephalopathy, or bleeding from esophageal varices * serum albumin levels \< 3.2 g/dl * inr \> 1.3 n * total bilirubin levels \> 2.0 mg/dl unless explained by gilbert's disease * platelet count \< 100,000 µl * absolute neutrophil counts \< 1500 µl (mm3) * active or suspected non-hepatic malignancy or history of malignancy within the last 5 years * body mass index \ 35 kg/m2 * females of childbearing potential: * pregnancy (i.e. positive urine pregnancy test at screening) or lactation * failure to agree to practice adequate contraception methods (e.g. oral contraceptives, intra-uterine device (iud), transdermal contraceptive patch) * male patients not vasectomized, who do not agree to abstain from intercourse or who do not use a condom

Keywords: hcv hepatitis c
revival active program for adolescents with depression

Conditions: Depression

Summary: active play and sports has shown to be effective intervention in managing depression. extending the support with mind body therapy, revival active program was designed as an early intervention for adolescents. to measure the efficacy and feasibility of the community based revival active play intervention for adolescent depression, present pilot study was undertaken.


Eligibility criteria:
inclusion criteria: * children diagnosed with depression as per the dsm iv-tr criteria * parents willing to give written informed consent exclusion criteria: * physical limitation for active sports * co-morbid mental health diagnosis * high risk of self harm/ suicide * history of self harm or harming someone else

Keywords: adolescent revival active program
augmentation of depression treatment by gamified network retraining

Conditions: Depression Mild; Cognitive Impairment; Cognitive Dysfunction; Depressive Disorder; Depression

Summary: major depressive disorder (mdd) is a highly prevalent and debilitating mental disorder with a high lifetime prevalence of 16-20%. particularly for people with low socio-economic status, the existing and effective treatment options are hard to reach and show weaker effectivities. there is a potential to ameliorate depressive symptoms and improve quality of life in persons with mild-to-moderate depression by providing access to stimulating computerized trainings. single computerized trainings that target depressive symptoms have been tested in laboratory and clinical settings so far. to date, innovative market access and confirmatory studies are missing for a large-scale implementation of such trainings. thereby, the present work will foster a digitalized training paradigm (paced-auditory serial addition task; pasat) which was previously shown to reduce depressive symptoms, but in a novel innovative and gamified form on a tablet-pc handed out to participants. different versions of the same training paradigm that comprise additional game elements will be compared. the feasibility study will gather data on effect size estimates of symptom severity reduction, user experience and usage in an ecological valid setting.


Eligibility criteria:
inclusion criteria: * full age (\> 18 years old) * consent * german mother tongue * presence of mild-to-moderate depressive symptoms (madrs \> 10 and \< 34 and confirmation of depressive symptoms in m.i.n.i. diagnostic interview) * stable or no medication with antidepressant drugs or other psychoactive agents (at least for 6 weeks) * no or current psychotherapy exclusion criteria: * presence of schizophrenia / psychotic disorder (according to m.i.n.i. diagnostic interview) * cognitive impairment * epilepsy
the effect of levetiracetam on the postmastectomy pain syndrome

Conditions: Postoperative Pain

Summary: the aim of this study is determine whether or not the antiepileptic drug levetiracetam is an effective treatment of the postmastectomy pain syndrome.

this study is a randomised, placebocontrolled, doubleblind study on the effect of the antiepileptic drug, levetiracetam, in patients suffering from pmps. the treatment periods are 1 month each and the periods are separated by a 1-week washout period. the daily dose of levetiracetam is increased over a 2-week period to 3.000 mg/day. the primary effect variable is pain relief by the use of numeric rating scale. secondary parameters are daily registration of pain performed by the patients during the treatment periods and the amount of escape medicine used (paracetamol and tramadol). sensory testing is performed at baseline and after each treatment period.

Eligibility criteria:
inclusion criteria: * symptoms characteristic for postmastectomy pain syndrome with a duration of more than 3 months and at least 6 months after the operation. * neuropathic pain diagnose confirmed by abnormities in the neurological investigation and/or psychophysical sensory testing * average (1 week) pain score minimum 4 on a 11 points numerical rating scale for total pain. * pain present minimum 4 out of 7 days. * fertile women must use anticonception. exclusion criteria: * verified og suspected other reason than mastectomy/lumpectomy for the pain. * known allergic effects to levetiracetam. * known sideeffects to treatment with levetiracetam. * pregnancy or breast-feeding. * severe disease (terminal cancer, heart failure, kidney insufficiency, severe respiratory problems) * compliance problems
korea atherosclerosis study-3

Conditions: Cardiovascular Diseases; Cardiovascular Mortality; All-cause Mortality

Summary: multidetector-row computed tomography (ct) has been introduced for use in the diagnosis of coronary heart disease. the investigators aimed to characterize coronary artery disease in subjects with cardiovascular risk or not, and in particular plaque natures depending on different status of cardiovascular risk. especially,the investigators will evaluate the relationships between the pericardial fat and severity of stenosis as well as plaque characteristics using logistic regression models.


Eligibility criteria:
inclusion criteria: * korean capable of multidetector-row cardiac computed tomography (mdct) exclusion criteria: * malignancy * infection * shock

Keywords: coronary artery disease cardiovascular risk pericardial fat
a clinical research study evaluating ropinirole treatment for restless legs syndrome (rls)

Conditions: Restless Legs Syndrome

Summary: a 12-week clinical research study to evaluate the tolerability, efficacy and safety of ropinirole compared to placebo(an inactive sugar pill) in the treatment of patients with rls in the united states.


Eligibility criteria:
â inclusion criteria: * patients diagnosed with restless legs syndrome (rls). * patients diagnosed with rls (symptoms include an overwhelming urge to move legs usually accompanied by uncomfortable sensations in the legs; usually occur at rest; worse during the evening or night and generally relieved, at least temporarily, by movement). * patients must give written informed consent prior to any specific study procedures. exclusion criteria: * patients with a primary sleep disorder other than rls. * patients with symptoms of secondary rls (i.e., renal failure, iron deficient anemia, pregnancy) or other movement disorders (i.e., parkinson's disease). * other inclusion or exclusion criteria to be evaluated by the physician.

Keywords: rls restless legs syndrome
tacrolimus for the treatment of superficial kaposiform hemangioendothelioma and tufted angioma

Conditions: Tacrolimus, Kaposiform Hemangioendothelioma, Tufted Angioma

Summary: the aim of this study was to evaluate the efficacy and safety of topical application of tacrolimus at different concentrations for superficial kaposiform hemangioendothelioma (khe) and tufted angioma (ta).

kaposiform hemangioendothelioma (khe) and tufted angiomas (ta) are rare vascular tumors, which are apparent predominantly in infancy or early childhood. currently, no standard treatment regimens exist for khe/ta. the aim of this study was to evaluate the efficacy and safety of topical application of tacrolimus at different concentrations for superficial kaposiform hemangioendothelioma (khe) and tufted angioma (ta).

Eligibility criteria:
inclusion criteria: * children with superficial kaposiform hemangioendothelioma (khe) and tufted angioma (ta) exclusion criteria: * hypersensitivity to tacrolimus mucosal kaposiform hemangioendothelioma (khe) and tufted angioma (ta)
evaluation of the bowel cleansing in hospitalized patients using pure-vu system

Conditions: Gastrointestinal Disease; Colorectal Cancer

Summary: the aim of this study is to evaluate the potential improvement in colonoscopy procedure's outcomes when using the pure-vu system in hospitalized patients who are indicated for colonoscopy procedure.

this multi-center, prospective, single arm study will include up to 100 patients (20-40 patients per site), aimed at evaluating the performance of the pure-vu system in cleansing hospitalized patients' colon who are indicated for standard colonoscopy procedure. subjects will be enrolled at up to 4 clinical sites in the united states and europe. subjects who meet the eligibility criteria will be prescribed a standard bowel preparation bowel preparation regimen including diet restrictions and oral bowel preparation. following the bowel preparation, the patient will undergo colonoscopy with the pure-vu system. in case of inadequate bowel preparation, as per the nurse report and / or bbps \< 2, in at least one of the colon segments, prior pure-vu use, the physician will complete a questionnaire on the patient's management standard of care assuming the absence of pure-vu. follow-up will be conducted at 48 hours (± 48 hours) post procedure.

Eligibility criteria:
inclusion criteria: 1. hospitalized patients who are indicated for a screening, diagnostic, surveillance or therapeutic colonoscopy 2. patients' age \> 22 years 3. patient has signed the informed consent exclusion criteria: 1. patients with known inflammatory bowel disease and / or active colitis 2. patients with active diverticulitis 3. patients with known or detected (during colonoscopy) bowel obstruction 4. patients with bmi ≤ 18 5. patients with ascites child pugh c 6. patients who are 30 days post-transplant 7. patients treated with peritoneal dialysis 8. patients under active iv inotropic medications 9. patients with lvad 10. patients who have active anticoagulant medications (excluding aspirin) or dual antiplatelet therapy in their system prior to the procedure. (note: to avoid exclusion therapy should be discontinued 48 hours or greater prior to the procedure based on discretion of physician) 11. subjects with known coagulation disorder (inr ≥ 2 or platelets \<50,000) 12. subjects with hemodynamic instability. 13. pregnancy (as stated by patient) or breast feeding 14. subjects with altered mental status/inability to provide informed consent 15. patients who have participated in another interventional clinical study in the last 2 months

Keywords: bowel prepartion
determination of pronostics factors for advanced thyroid carcinoma (pt3 pt4 or m1 at diagnosis)

Conditions: Thyroid Cancer

Summary: it is generally estimated that 5 % of patients with thyroid cancer will develop distant metastases, and most of them had an advanced stage of the disease at presentation. thirty per cent of them are resistant to radio iodine therapy and are called "refractory". their long term survival is estimated to be less than 10 %. the objective of this study is to identify the factors associated with poor outcome in a cohort of patients with advanced thyroid cancer followed during 5 years. anaplastic and medullary thyroid carcinomas were excluded.


Eligibility criteria:
inclusion criteria: * man or woman ≥ 18 years. * thyroid cancer differentiated from follicular origins (papillary, vesicular or poorly differentiated carcinoma). * tnm classification: stage pt3 (≥2 cm), or pt4 or m1 at diagnosis. * patient after post operative radioiodine therapy. exclusion criteria: * patient who can not be followed during the protocol. * patient who does not consent.

Keywords: thyroid carcinoma predictive factors refractory differentiated follicular origin
open technique erector spinae plane block in spinal surgery

Conditions: Postoperative Pain; Erector Spinae Plane Block in Spinal Surgery

Summary: erector spinae plane (esp) block is an interfacial plane block with visceral and somatic analgesic activity at paraspinal muscles.espb has been successfully applied as a part of multimodal analgesia in treating postoperative pain in spinal surgery. however, it may be difficult or impossible to perform lumbar espb in obese patients or cases of increased lumbar lordosis. this study aims to investigate the effectiveness of espb applied by the intraoperative surgeon.


Eligibility criteria:
inclusion criteria: * asa i-iii patients * agreed to participate in the study exclusion criteria: * patients with infection at the injection site * coagulopathy allergy to amide-type local anesthetics * history of peripheral neuropathy * hepatic and/or renal failure * refusing the procedure * patients with heart disease * patients who have previously undergone surgery from the same area

Keywords: pain postoperative analgesia erector spinae plane block spinal surgery open technique
a study of response to standard treatment before surgery in people with rectal cancer

Conditions: Rectal Cancer; Adenocarcinoma of the Rectum

Summary: the purpose of the study is to learn more about how the body responds to standard treatment (chemoradiation and chemotherapy). the study will use the results of testing down on participants' blook, tissue, and scans to learn more about how people with rectal cancer respond to chemoradiation and chemotherapy treatment and if it is useful for predicting whether a person's cancer get better, gets worse, or stats the same after treatment.


Eligibility criteria:
inclusion criteria: * 18 years of age or older on day of signing informed consent. * have a histologically confirmed diagnosis of invasive adenocarcinoma of the rectum with no known mismatch repair deficiency or her2 amplification. * eligible for and plan to initiate standard-of-care therapy with any of the following regimens: * induction fluoropyrimidine (capecitabine \[preferred\] or 5-fu) based chemoradiation * with plan for consolidative capeox, folfox, or folirinox * woman with childbearing potential who are negative for pregnancy test (urine or blood) and who agree to use an effective contraceptive method. a woman of childbearing potential is defined as one who is biologically capable of becoming pregnant. reliable contraception should be used from the time of screening and must be continued throughout the duration of treatment as per standard of care. exclusion criteria: * patients with a prior or concurrent malignancy whose natural history or treatment has the potential to interfere with the safety or efficacy assessment of the investigational regimen. * patients with prior external beam radiation therapy to the pelvis or brachytherapy seed implantation of the prostate. * patients who are pregnant or breastfeeding. * men or women not using effective contraception. * patients with a contraindication to mr imaging. * patients on blood thinners prohibiting endoluminal tumor biopsies.

Keywords: rectal cancer adenocarcinoma of the rectum memorial sloan kettering cancer center 24-238
new therapeutic strategies for the treatment of alcohol use disorders

Conditions: Alcoholism

Summary: this is an experimental study in which the efficacy of three psychophysiological intervention modalities based on retrieval-extinction procedures is analyzed.

behavioral inhibition processes are a particularly relevant in relapses of patients with alcohol dependence. one of the current behavioral techniques to improve inhibitory abilities of these patients is the alcohol approach avoidance task (aat). however, this technique could be more efficient if patients, before training in this task, were exposed to a variety of alcohol-conditioned stimuli (retrieval) and take advantage of the window period of reconsolidation of these memories to carry out this task (extinction training). this project will attempt to show the pattern of brain connectivity underlying retrieval-extinction learning, its relationship with markers such as brain-derived neurotrophic factor (bdnf) and their usefulness to reduce relapses of individual with alcohol dependence. to carry out this study 115 patients with alcohol dependence who will be randomized into three groups: group 1 (n = 35) where the extinction training is performed within the window period (10 minutes); group 2 (n = 35) extinction will take place outside the time window (6 hours); group 3 (n = 35), these subjects will be exposed to "non-retrieval" but with extinction-training within the window period. changes in connectivity will be assessed with electroencephalogram (eeg) at baseline and after 4 training sessions, using the hermes platform. bdnf levels will be determined as peripheral markers of neurogenesis. these changes will be are correlated with relapses in the 12 weeks of follow-up.

Eligibility criteria:
inclusion criteria: * alcohol-dependent patients who have been detoxified and abstinent take 10-14 days. exclusion criteria: * patients who do not sign the informed consent.

Keywords: alcohol dependence brain connectivity inhibition
integrated neuromuscular inhibition, muscle energy and strain counter strain techniques in neck pain

Conditions: Neck Pain

Summary: 1. to determine effects of neuromuscular inhibition, muscle energy and strain counter strain techniques on pain, disability, pain pressure threshold, range of motion, and health-related quality of life in mechanical neck pain. 2. to compare the effects of integrated neuromuscular inhibition, muscle energy and strain counter strain techniques in the management of mechanical neck pain.


Eligibility criteria:
inclusion criteria: * participants falling in this category would be recruited into the study. * patients with chronic mechanical neck pain (symptoms for more than 3 months). * age group between 30 - 60 years. * patients willing to participate and take treatment. * patients must have at least 1 active trigger point at upper trapezius, levator scapulae, scm. * gender (both) * vas \>3 exclusion criteria: * • patients having severe neck pain. * patients having any systemic joint pathology, inflammatory joint disease (e.g rheumatoid arthritis, gouty arthritis, psoriatic arthritis). * patients who had any neurological deficit, myelopathy any mental illness. * patients on medication like antidepressants, corticosteroid, anti-inflammatory medications.

Keywords: mechanical neck pain chronic neck pain muscle energy technique strain counter strain init