Kornimate/medical-research-clean huggingface dataset:
osteopathic manipulative treatment in individuals with temporomandibular disorder who make use of occlusal splints

Conditions: Temporomandibular Disorder

Summary: this study aim to contribute with the investigation of the therapeutic effect of osteopathic manipulative treatment in pain intensity and quality of life in individuals diagnosed with temporomandibular disorder who make use of occlusal splints.

objective: it is known the multifactorial etiology of temporomandibular disorders(tmd) which raises the need of a multidisciplinary approach for its treatment. studies have presented good results about the use of occlusal splints along with other therapies. the osteopathic manipulative treatment(omt) has as characteristic the philosophy of global approach and precise functional diagnosis. based on a lack of randomized blind trials about this subject, this study aim to contribute with the investigation of the therapeutic effect omt in pain intensity and quality of life in participants diagnosed with tmd making use of occlusal splints. methodology: this study is a randomized blind trial, with sample composed by 18 participants referred to the occlusion clinic of fluminense federal university (uff), diagnosed by the team of dentists and interns of occlusion clinic through the research diagnostic criteria for temporomandibular disorders (rdc/tmd). the participants will complete the short form 36 health survey(sf-36) to measure the quality of life, and pain intensity diagram with numeric rating scale (nrs) to measure the pain intensity. the sample will be randomized into 2 groups (9 individuals for each): test group (tg) - patients subject to clinical treatment with splints (ct) offered at the occlusion clinic unit along with osteopathic manipulative treatment - omt. control group (cg) - patients subject only to ct and will receive a sham treatment that simulate the omt to blind these participants. after the treatment, patients will be re-evaluated in 8 weeks' time. statistical analysis: the sf-36 and the pain intensity and the most intense pain evaluation diagram with numeric rating scale (nrs) will be performed by the wilcoxon's non parametric test.

Eligibility criteria:
inclusion criteria: * individuals who has diagnosis of temporomandibular disorder. exclusion criteria: * individuals who already has subjected to osteopathic manipulative treatment to temporomandibular disorder.

Keywords: osteopathic manipulative treatment temporomandibular disorder
endothelial dysfunction in obese children

Conditions: Obesity; Atherosclerosis

Summary: the purpose of this study is to objectify the effect of diet and exercise on early markers of atherosclerosis in obese children.

the favorable responses of combined treatment strategies, consisting of exercise training and proper diet change, for childhood and adolescent obesity on vascular health are poorly understood. the overall objective of this research project is to investigate the underlying pathophysiological mechanisms that mediate these beneficial effects. particularly, the following aims are set forth: 1. to establish the effect of a combined lifestyle intervention, i.e. an individualized exercise training and caloric restriction program, on vascular function (primary endpoint) and structure in a substantial population of obese adolescents. 2. to characterize causal pathways between obesity and endothelial dysfunction with focus on classical risk factors, oxidative and inflammatory stress, metabolic adaptations, bone marrow derived progenitor cells, and blood microparticles. this research knowledge will be instrumental for risk stratification and clinical management aimed to improve endothelial function by limiting damage and reinforcing regenerative mechanisms in obese adolescents.

Eligibility criteria:
inclusion criteria: children with severe obesity * younger than 16 yrs: bmi ≥97th sex and age specific bmi-percentile * older than 16 yrs: bmi ≥35 kg/m² exclusion criteria: * acute or chronic inflammatory process, use of non-steroidal anti- inflammatory drugs or immunosuppressive drugs. (including inhalation corticosteroids). * structural heart disease or other cardiac diseases. * active malignant hematological disease

Keywords: overweight cardiovascular risk factors exercise training endothelial function endothelium endothelial progenitor cells
a study of shr6390 combined with famitinib in the treatment of er + / her2- advanced breast cancer

Conditions: ER+ / HER2- Advanced Breast Cancer

Summary: the study is being conducted to assess the safety 、tolerability 、 pharmacokinetics and efficacy of shr6390 combined with famitinib in the treatment of er + / her2- advanced breast cancer.


Eligibility criteria:
inclusion criteria: 1. female subjects aged 18 to 75 years old； 2. ecog performance status 0-1; 3. life expectancy is not less than 12 weeks; 4. histological or cytological confirmation of er+/her2- recurrent/metastatic breast cancer; 5. participants with measurable disease must have at least one "target lesion" to be used to assess response on this protocol as defined by recist1.1; 6. adequate function of major organs; 7. voluntary participation in the study, signed informed consent, good compliance and willingness to cooperate with follow-up. exclusion criteria: 1. confirmed diagnosis of her2 positive disease; 2. participants who previously received shr6390 or vegfr inhibitors; 3. allergy to study drug or its components; 4. participated in other drug clinical trials within 4 weeks before the first dose; 5. other malignancies within 3 years, except cured non-melanoma skin cancer , skin basal cell carcinoma and squamous-cell carcinoma or carcinoma in situ of the cervix; 6. clinically significant cardiovascular and cerebrovascular diseases,including but not limited to severe acute myocardial infarction within 6 months before enrollment, unstable or severe angina, congestive heart failure (new york heart association (nyha) class \> 2), or ventricular arrhythmia which need medical intervention； 7. tumor has invaded important blood vessels or the tumor is likely to invade important blood vessels and cause fatal hemorrhage during treatment; 8. urine routine test indicates urine protein ≥(++), or 24-hour urine protein \>1.0g; 9. active hbv/hcv/hiv infection; 10. the investigators determined that other conditions were inappropriate for participation in this clinical trial； 11. pregnant or breast-feeding women; 12. central nervous system (cns) invasion.
olive leaf extracts in the control of hypertension

Conditions: Hypertension

Summary: this study will be carried out in 2 emergency departments (at the exit of the emergency room) and 2 external consultations (endocrinology of the chu fb monastir and diabetology consultation, jemmal hospital). patients over 18 years of age with: arterial hypertension (hypertension).

this study will be carried out in 2 emergency departments (at the exit of the emergency room, patients included in the gr2 study) and 2 external consultations (endocrinology of the chu fb monastir and diabetology consultation, jemmal hospital). all the population will benifit of a biological assessment which include: complete lipid profile, blood sugar, creatinine one population will be randomized: the population of patients with hypertension. for patients in the hypertension group: a blood pressure with holter will be carried out for 24 hours .

Eligibility criteria:
inclusion criteria: * patients over 18 years of age with: arterial hypertension (hypertension) exclusion criteria: * . exclusion criteria: none.

Keywords: hypertension
prophylactic mesh to reduce the incidence of ventral hernia

Conditions: Ventral Hernia

Summary: the incidence of ventral hernias has remained inappropriately high. any innovation in order to reduce this incidence would be simply cost-effective. although there is still some concern about the use of mesh in clean-contaminated or contaminated surgery, based in our experimental studies, we plan to use a mesh in the primary closure of abdominal incision to prevent incisional hernias. the investigators propose a clinical trial to assess a model to prevent the incisional hernia after laparotomy to treat colorectal carcinoma is scheduled. a simple randomization is scheduled: in the intervention group a prefascial large-pore low-weight 5 cm wide polypropylene mesh is fixed covering the midline closure; in the control group a conventional closure with a running suture of long-term absorbable material with a suture/wound length ratio 4:1. the sample size was calculated with an estimated incidence of ventral hernia of 25% in the control group and 10% in the intervention group, 0,05 alfa and a 0,15 beta error. the main goal is the appearance of a ventral hernia after 24 months of follow-up. other outcomes are wound complications and morbidity. exclusion criteria are adult patients with a previous ventral hernia, estimated survival of less than 6 months or hemodynamic instability during surgery. the diagnosis of ventral hernia will be assessed by clinical exploration on 3,6,12,18 and 24 months and abdominal ct controls at 6,12, and 24 months. the study will be statistically evaluated with spss 18.0.


Eligibility criteria:
inclusion criteria: * more than 18 years old. * patients operated with elective or emergency midline laparotomy with the diagnosis of colorectal cancer. * written informed consent or oral consent with the present of two witnesses who do not participate as investigators in the trial exclusion criteria: * dissemination of oncologic disease: all stage iv tumors with estimated survival less than 3 months. * simultaneous participation in another trial with interference of intervention and outcome. * withdrawn or missing written consent. * mental condition rendering the subject incapable of understanding the nature, scope and consequences of the trial. * previous ventral hernia

Keywords: ventral hernia surgical meshes polypropylenes
a survey to evaluate diabetes management, control, chronic complications, psychosocial aspects of diabetic subjects in malaysia

Conditions: Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2

Summary: this study is conducted in asia. the aim of this observational study is to evaluate current status of diabetes management, control, and complications in diabetic subjects in asia.


Eligibility criteria:
inclusion criteria: * diabetic patients registered in the particular centre for more than 12 months. * patients should have visited the centre at least once in the last 3-6 months apart from the initial visit. * patients willing to sign informed consent form. exclusion criteria: * repetition of any patient as patients should not be included twice for any reason. * unwilling to participate or unable to comply with protocol requirements.
study of topical abi-1968 in subjects with precancerous cervical lesions from human papillomavirus (hpv) infection.

Conditions: HSIL of Cervix; HSIL, High Grade Squamous Intraepithelial Lesions; High-Grade Cervical Intraepithelial Neoplasia; Human Papilloma Virus; HIV Negative; Cervical Cancer; CIN - Cervical Intraepithelial Neoplasia; Cervical Neoplasm; Cervical Dysplasia

Summary: this study evaluates the use of abi-1968, a topical cream, in the treatment of cervical precancerous lesions in females without human immunodeficiency virus (hiv) infection.


Eligibility criteria:
inclusion criteria: 1. women, 25 to 50 years old. 2. biopsy-confirmed cervical hsil that is p16+ within 60 days of enrollment (dosing) with no evidence of invasive cancer in any specimen. 3. colposcopy is satisfactory based on visualization of the entire squamo-columnar junction (scj). the borders of all lesions must be completely visible. 4. the upper limit of the visible (usually aceto-white) lesion is within 3 quadrants or less at screening. exclusion criteria: 1. women who are pregnant, plan to become pregnant in the next 4 months, or lactating females. 2. hiv positive (tested at screening visit or within 3 months of screening visit). 3. resolution of visible cin lesion prior to enrollment. 4. ecc positive for glandular disease (adenocarcinoma in situ) or invasive cancer. 5. history of cervical cancer, colposcopy suspicious for cancer, any prior treatment of cin, or hysterectomy.
reproductive health survivorship care plan

Conditions: Breast Cancer; Hot Flashes; Sexual Dysfunction; Fertility; Contraception

Summary: the investigators propose to test the efficacy of the reproductive health survivorship care plan (scp-r), a novel survivorship care tool to meet the reproductive health needs of young breast cancer survivors (ybcs). most ybcs undergo chemotherapy and/or endocrine therapy, treatments that impair ovarian function and result in significant reproductive health late effects. these late effects include symptoms of estrogen deprivation such as hot flashes, fertility concerns, limited contraception options and sexual problems. together they have a major, negative impact on quality of life. despite substantial research, treatment guidelines and clinical expertise on these issues, most ybcs and their healthcare providers have limited guidance on how best to manage these reproductive health late effects. the research team has generated a practical, accessible, evidence-based reproductive health survivorship care plan (the scp-r) for ybcs and their providers to address this deficit in survivorship care. this clinical trial will test if ybcs who receive the web-based scp-r are more likely than controls to improve on at least one of these reproductive health issues: hot flashes, sexual health, fertility concerns, and contraception.

participants may be recruited from throughout the united states, as all study activities may be done remotely. it is not necessary to live in san diego or visit uc san diego to participate in the study. ybcs who are interested in the study will be provided access to an online screening survey to determine eligibility. eligible ybcs who consent to the study will be followed for 24 weeks. following a one-week study run in, ybcs participants will be randomized to the scpr intervention or control arms and receive the corresponding interventions. all ybcs participants will complete 3 study time points at enrollment, 12 and 24 weeks. at each time point, they will complete a web-based study questionnaire on medical and reproductive health. ybcs participants will also daily track their hot flashes via text messaging. ybcs participants will designate a healthcare provider with whom they would discuss reproductive health issues. designated healthcare providers will be approached to participate in the study. those providers who enroll will complete 2 study assessments at weeks 0 and 24. at each study time point, hcp will be assessed for preparedness on managing reproductive health issues by a web-based questionnaire.

Eligibility criteria:
inclusion: * breast cancer (stages 0-iii) diagnosis * breast cancer diagnosis age ≤ 45 years * ≤ 5 years since breast cancer diagnosis * current age 18 to 50 years * completed treatment with surgery, radiation and chemotherapy (if applicable) * able to read english * able to consent to the study * access to an internet connection exclusion: • women who are pregnant at recruitment

Keywords: breast cancer survivor cancer survivorship survivorship care plan vaginal dryness vulvovaginal atrophy vasomotor symptom infertility family planning
occupational therapy's role in promoting community wellness utilizing sit-stand workstations

Conditions: Musculoskeletal Pain; Musculoskeletal Strain; Sedentary Lifestyle

Summary: the aim of this study is to combat the growing global health issue of sedentary behavior and the associated health consequences of prolonged sitting in the workplace. the population of desk-based workers makes up a relatively large population and are an important target for this health promoting initiative with a focus on improving posture, encouraging movement, and fostering a more active and healthy business community. it's important to recognize that occupational therapy practitioners can contribute to community health promotion/disease prevention programs by the skill-set of practitioners to understand habits and routines that influence the adoption and maintenance of healthy behaviors.


Eligibility criteria:
inclusion criteria: * participants must spend \> 50% of their work day seated at the computer * participants must be primarily english speaking * participants must work within the health sciences center building at west virginia university exclusion criteria: * participants who are less than 18 years of age * participants who are not primarily english speaking * participants who spend \<50% of their work day seated at the computer * participants who do not work within the health sciences center building at west virginia university * participants who are pregnant
rbd longitudinal as prognostic for pd

Conditions: Rapid Eye Movement Sleep Behavior Disorder

Summary: * purpose - to validate a combination of biological and clinical markers in the rapid-eye-movement (rem) sleep behavior disorder (rbd) population as indicative of the pre-symptomatic stage of parkinson's disease (pd). * procedures - all subjects (rbd diagnosis and controls) will have 1) a medical and neuro history and physical including videotape of movements, 2) neuropsychological testing, 3) a sleep study, 4) olfactory testing, 5) blood draw for serum testing , 6) functional mri. all of these procedures are often performed clinically in the diagnosis of pd. enrollment of subjects with pd is complete. any testing performed prior to enrollment as part of the clinical evaluation may be used in place of repeating the procedure for the study. subjects will be followed for 5 years. it is hypothesized that a 5 year follow up may capture a significant number of pre-parkinson's subjects who will be diagnosed. subjects may be offered a repeat enrollment after 5 years.

enrollment of pd and ps cohorts is complete. currently enrolling only confirmed rbd and controls.

Eligibility criteria:
inclusion criteria: 1. 35-70 year old men \& women 2. (1) diagnosis of idiopathic rbd (see aasm criteria), 2) normal control or control with a non-neurodegenerative disorder, age and gender-matched to (1) 3. gives written informed consent 4. pregnant women are not excluded, but will be identified by hcg. exclusion criteria: a a diagnosis of any non-parkinsonian neurodegenerative disease. b. any unstable or uncontrolled medical or psychiatric condition. c. parasomnia or rbd not idiopathic, eg., secondary to metabolic derangement or medicine effect. d. renal (creatinine over 1.6) or hepatic insufficiency (lft significantly out of range), or a history of significant uncontrolled cardiac disease. e. significant dementia (mmse\<25 of 30 or moca\<25/30) that would interfere with study procedures or informed consent. f. any reason which, in the opinion of the pi, would increase the risk or decrease the value of any study procedure. g. fmri will not be performed for anyone for whom the screening questionnaire indicates is ineligible for mri imaging.

Keywords: rapid eye movement sleep behavior disorder parkinson's disease parkinsonian syndromes atypical parkinson's rbd pd fmri psp msa
computed tomography (ct) scans using ct-on-rails™ to pinpoint the location of the tumor in treating patients with prostate cancer

Conditions: Prostate Cancer

Summary: rationale: new imaging procedures such as ct-on-rails™ may improve the ability to pinpoint the location of the tumor and decrease radiation therapy damage to healthy tissue. purpose: this phase i/ii trial is studying how well computed tomography (ct) scans using ct-on-rails™ work in pinpointing the location of the tumor in patients with prostate cancer.

objectives: primary * validate the software for ct-on-rails™ by comparing prostate target localization via daily ultrasound vs computed tomography (ct) in patients undergoing radiotherapy for prostate cancer. secondary * determine the potential benefit of using fiducials in the prostate of patients undergoing daily ct scans and/or ultrasounds for localization. * determine the intra- and inter-radiation treatment setup and target position uncertainties, in terms of isocenter coordinates in space, using both the ultrasound and ct scans compared to the coordinates of the isocenter determined at simulation, in these patients. outline: this is a pilot study. * phase i: patients undergo computed tomography (ct) using ct-on-rails™ twice weekly. patients undergo bat™ ultrasound daily for prostate localization. patients undergo concurrent daily radiotherapy off study after imaging. after radiotherapy treatment is complete, patients continue to undergo scanning using ct-on-rails™ twice weekly. * phase ii: patients undergo local anesthesia and surgical insertion of gold fiducial markers into the prostate. after 1 week, patients undergo a daily ct scan using ct-on-rails™ and bi-weekly bat™ ultrasound. patients undergo daily radiotherapy off study after imaging. after radiotherapy treatment is complete, patients continue to undergo scanning using ct-on-rails™ twice weekly. projected accrual: a total of 40 patients (20 per study phase) will be accrued for this study.

Eligibility criteria:
disease characteristics: * diagnosis of definitive prostate cancer * radiotherapy planned as treatment patient characteristics: age * any age performance status * not specified life expectancy * not specified hematopoietic * not specified hepatic * not specified renal * not specified prior concurrent therapy: biologic therapy * not specified chemotherapy * not specified endocrine therapy * not specified radiotherapy * see disease characteristics surgery * not specified

Keywords: recurrent prostate cancer stage i prostate cancer stage ii prostate cancer stage iii prostate cancer stage iv prostate cancer