Kornimate/medical-research-clean huggingface dataset:
efficacy and safety of huzhen capsule for treatment of patients with acute gout

Conditions: Acute Gout

Summary: this study is a multi-center, double-blind, randomized, parallel controlled trial. patients with acute gout will be enrolled and randomly allocated into 2 groups: huzhen capsule treatment group and placebo control group. randomization codes were established by the biostatistician. observe will be followed for 3 days (72 hours) after the onset. change of vas score from baseline, proportion of improvement with damp-heat retention, change in c-reactive protein (crp) and erythrocyte sedimentation rate ( esr) from baseline, change in white blood cell count in whole blood cell analysis from baseline, and the number of adverse events will be monitored and compared between each groups.

the test group will be given huzhen capsule 1.6g three times per day,the control group will be given placebo 1.6g three times per day. the invention will last 3 days.

Eligibility criteria:
inclusion criteria: 1. score is equal to or larger than 40cm on the 0-100cm vas pain scale. 2. acute attack of gout no longer than 2 days. 3. participant with acute gout is diagnosed as "damp-heat retention" by traditional chinese medicine. 4. age 18-65 years with informed consent. exclusion criteria: 1. chronic gouty arthritis. 2. pseudogout, acute rheumatic fever and suppurative arthritis, traumatic arthritis, erysipelas, meander rheumatism and other arthritis. 3. anti-inflammatory medication for the treatment of acute gout. 4. pregnant or breastfeeding women. 5. history of severe allergy, including diclofenac sodium. 6. serum creatinine is higher than the upper normal limit. alt or ast is higher than the upper normal limit for two times. 7. fever ( t\>38.5 ℃)
effect of diabetes on short i̇mplants in one- and two-stage surgeries

Conditions: Dental Implant Surgical Techniques; Diabetes Mellitus; Short Dental Implants

Summary: the goal of this clinical trial is to compare one- and two-stage techniques for short implant surgery in diabetes. the main questions it aims to answer are: * is one-stage short implant surgery at risk of implant osseointegration in diabetic patients compared to two-stage surgery? * is one-stage short implant surgery associated with a risk of implant survival (at one-year follow-up) in diabetic patients compared to two-stage surgery? * what are the effects of one- and two-stage short implant surgery on the marginal bone loss or isq (implant stability coefficient - resonance frequency analysis device measurement) values of the implant in diabetic patients? participants will come for their 3rd, 6th and 12th month controls. * participants will receive two adjacent short implants. * a randomly selected one of these short implants will undergo a one-stage implant surgery, and the other a two-stage implant surgery. * data will be obtained through non-invasive evaluation methods during the surgery and subsequent control stages. researchers will also test one- and two-stage short implant surgeries in a control group of healthy individuals. thus, the effects of diabetes on these two techniques will be better understood by comparing them with the healthy control group.


Eligibility criteria:
inclusion criteria: * the maxillary and mandibular posterior region (distal part of the canine in each quadrant) must have toothless space for two adjacent short implants. * the edentulous space must have a vertical bone height of at least 5 mm. (distance to maxillary sinus and alveolar nerve) * the edentulous space should not require horizontal bone augmentation. (for implants with diameters 3.7 - 4.1 - 4.7 - 5.3) * bleeding on probing should be less than 10%. there should be no pathological pockets in any tooth. * participant should not smoke more than 10 cigarettes per day. * more than 6 months must have passed since the tooth extraction from the edentulous area. * should not have bruxism * if it is diabetes, the hba1c value should be greater than 6.5, and if it is healthy control, the hba1c value should be between 4 and 5. exclusion criteria: * having psychological problems * smoking more than 10 cigarettes per day * pregnancy status if female patient * having a medication or disease that will cause abnormal post-operative bleeding * alcohol and drug use

Keywords: dental implants short dental implants one stage implant surgery two stage implant surgery diabetes mellitus
relationship of pakt to survival in patients with node-positive breast cancer

Conditions: Breast Cancer

Summary: this study will examine the relationship of a protein called pakt to survival of breast cancer patients with one or more positive axillary lymph nodes. akt plays a role in cell survival, tumor formation, and the development of drug resistance. the study will use tumor tissue obtained from 2,000 patients enrolled in a national surgical adjuvant breast and bowel project study that is evaluating whether adding the drug paclitaxel (taxol (registered trademark)) to a treatment regimen of doxorubicin (adriamycin (registered trademark)) and cyclophosphamide (cytoxan (registered trademark)) improves disease-free survival and overall survival in patients with node-positive breast cancer. the current study will measure levels of pakt in the tissues and correlate the results with clinical outcome to see if pakt levels are associated with improved patient survival. ...

taxanes (paclitaxel and docetaxel) have emerged as the most powerful chemotherapeutics in breast cancer over the past decades. the b-28 clinical trial from the national surgical adjuvant breast and bowel project (nsabp) assesses the efficacy of adding paclitaxel to the doxorubicin/cyclophosphamide regimen in the treatment of patients with axillary node positive breast cancer. the primary aim of b-28 is to determine whether four cycles of paclitaxel (taxol (registered trademark)) (t) following four cycles of postoperative doxorubicin (adriamycin (registered trademark) (a) and cyclophosphamide (c) will more effectively prolong disease-free survival (dfs) and survival (s) than four cycles of ac alone in patients with operable breast cancer who have one or more histologically positive axillary lymph nodes. the b-28 clinical trial tissue microarray consists of specimens from 2,000 cases enrolled. the tissue microarray set is an ideal platform for evaluating predictive markers of doxorubicin and/or paclitaxel response or resistance. akt, a serine/threonine protein kinase regulated by the phosphatidylinositol 3-kinase (pi3k), is of importance in cell survival, tumorigenesis, and recently shown, chemoresistance. it confers survival advantage to cells by transducing signals from growth factor receptors that activate pi3k. the primary aim of this study is to evaluate whether the levels of phosphorylated akt are associated with disease-free and overall survival in patients with node-positive breast cancer treated with ac and/or ac followed by paclitaxel.

Eligibility criteria:
* inclusion criteria the nsabp b-28 trial enrolled women from 1995 to 1998 with operable breast cancer with pathologically positive axillary lymph nodes.

Keywords: adjuvant therapy paclitaxel chemoresistance serine/threonine kinase cell survival breast cancer
stem cell therapy in limb girdle muscular dystrophy

Conditions: Limb Girdle Muscular Dystrophy

Summary: the purpose of this study was to study the effect of stem cell therapy on the course of the disease in patients with limb girdle muscular dystrophy.


Eligibility criteria:
inclusion criteria: * males and females * age group of 15 years and above * limb girdle muscular dystrophy diagnosed on the basis of clinical presentation * electromyographic and nerve conduction velocity findings exclusion criteria: * presence of respiratory distress * presence of acute infections such as human immunodeficient virus/hepatitis b virus/hepatitis c virus * malignancies * acute medical conditions such as respiratory infection, fever, hemoglobin less than 8, bleeding tendency, bone marrow disorder, left ventricular ejection fraction \< 30% * pregnancy or breastfeeding
folfoxiri plus cetuximab versus folfoxiri plus bevacizumab in conversion therapy of right-sided colon cancer liver metastases

Conditions: Liver Metastasis Colon Cancer

Summary: to compare the efficacy of folfoxiri plus cetuximab and folfoxiri plus bevacuzumab in the conversion therapy of right-sided colon cancer liver metastases


Eligibility criteria:
inclusion criteria: * ecog perfomance 0-1 * pathologically confirmed colorectal carcinoma, with ras wild type * inital unresectable liver metastases discussed by mdt * prior no systemical therapy or exceed 6 months after the adjuvant chemotherapy of primary tumor surgery. * without extraheptic metastatic lesions, except for locally controlled lung metastases (rfa or sbrt) * adequate blood, liver and renal function * expected survival longer than 6 months exclusion criteria: * with bleeding risk * interestinal obstruction or disease * uncontrolled hypertension and severe heart disease * previous severe thrombotic events * central nervous system metastases * accompanied with other malignant tumor

Keywords: folfoxiri cetuximab bevacizumab
development of a celiac safe food additive

Conditions: Gluten Intolerance

Summary: the goal of this clinical trial was to investigate if intestinal deamidation of gliadin from wheat bread could be hindered by adding a e304i/zinc additive. the study was a randomized double-blind 4-week crossover intervention in 20 healthy volunteers in which the participants ingested 2 bread rolls a day during the intervention weeks. the question it aimed to answer was if there was a difference in blood levels of deamidated gliadin peptides after ingestion of the reference wheat bread compared with the wheat bread containing the food additive.


Eligibility criteria:
inclusion criteria: * signed informed consent * body mass index between 18.5 to 32 * age between 18-50 years * no tobacco use exclusion criteria: * celiac disease and other diagnosed enteropathies * gluten-free diet * dietary supplementation (minerals (calcium, zinc, vitamin d) and proteolytic enzymes, probiotics) * pregnancy or lactation * lack of suitability for participation in the study, for any reason, as judged by the medical doctor or the project pi. * withdrawn consent: participant withdraws consent. * non-compliance: participant fails repeatedly to comply with study protocol (diet, study visits and provide samples)
clinical observation and mechanism study of yunnan baiyao in different stages of diabetic foot

Conditions: Diabetic Foot; Therapeutics

Summary: yunnan baiyao has been treating all kinds of wounds for 120 years, but the evidence of evidence-based medicine that is truly convincing is insufficient, making its best application method unclear. this study explored the possible indications and use methods of yunnan baiyao in different stages of diabetic foot, and obtained evidence-based medicine evidence of clinical efficacy. obtain the discarded tissues of diabetic foot patients in the treatment and control groups of yunnan baiyao after wound debridement, conduct transcriptome (bulkrna seq) analysis and detection on the wound tissues, and analyze the related signal pathways and functional genes with significant differences, to help clarify the possible treatment targets of yunnan baiyao.


Eligibility criteria:
inclusion criteria: 1. the age of the subjects is 18-80 years old; 2. diagnose diabetes according to who standards; 3. diagnosis of diabetic foot; 4. confirmed as one of the stages of infection progression and granulation growth; 5. voluntarily participate in this study and sign an informed consent form. exclusion criteria: 1. severe diseases such as acute myocardial infarction, heart failure, hepatitis, shock, and respiratory failure have not been corrected yet; 2. blood glucose is out of control, glucose test#fasting blood sugar\&gt;15mmol /l, glycated hemoglobin\&gt;12%; 3. there is active bleeding inside the wound, and routine basic treatment plans cannot be implemented; 4. serum albumin\&lt;20g/l; hemoglobin\&lt;60g/l; platelets\&lt;50 × 109/l; 5. late stage subjects with malignant tumors; 6. active period of autoimmune diseases; 7. have a history of allergy to yunnan baiyao; 8. the subject is unable to cooperate or has mental disorders; 9. according to the judgment of the researcher, the subject has a clear reason that cannot be removed and affects wound healing, which is not suitable for this study or cannot comply with the requirements of this study.

Keywords: diabetic foot therapeutics
wearable sensors for quantitative assessment of motor impairment in huntington's disease huntington's disease

Conditions: Huntington Disease

Summary: the principal means of measuring motor impairment in huntington disease (hd) is the unified huntington's disease rating scale (uhdrs) total motor score, which is subjective, categorical, requires significant training to administer correctly, and only captures impairments in clinic. in this direct to phase ii sbir we will develop a wearable sensor system for objective, sensitive, and continuous assessment of huntington's chorea during activities of daily living. the developed technology could be used clinically to detect changes in motor function in response to medications, or could be used scientifically to expedite and reduce the cost of early stage pharmaceutical clinical trials.


Eligibility criteria:
inclusion criteria: * cag expansion ≥ 36 exclusion criteria: * n/a
acupuncture for unexplained subfertiliy

Conditions: Unexplained Infertility

Summary: infertility affects one in six couples. in a quarter of them, routine tests of semen quality, ovulation or tubal patency fail to reveal any abnormalities and the cause of infertility is unexplained. acupuncture is being increasingly used by couples with all types of infertility and initial trials have suggested that it could be potentially beneficial in some cases. a number of systematic reviews of acupuncture in ivf have shown conflicting results, but there is no evidence to inform best practice in unexplained infertility. in addition, as an intervention, acupuncture is not cost neutral as it involves multiple visits for treatment sessions delivered by a skilled practitioner. thus, while acupuncture could have the potential to increase live birth rates in women with unexplained infertility, the clinical and cost effectiveness of acupuncture needs to be confirmed in the context of a large randomized controlled trial.


Eligibility criteria:
inclusion criteria 1. women aged 18-40 years 2. bilateral patent tubes demonstrated by hysterosalpingogram, hysterosalpingo-contrast sonography or laparoscopy 3. regular menses 21 to 35 days normal semen parameters :total motile sperm count ≥10 million. (world health organization criteria, 2010) exclusion criteria 1. unwillingness to accept either of the two interventions 2. contra-indications to acupuncture: pacemaker use or bleeding disorder 3. received acupuncture before 2 months for other diseases which are not related to unexplained infertility. 4. previously received acupuncture for unexplained infertility 5. use of hormonal or other medication (including chinese herbal prescriptions) which may affect the outcome in the past 2 months. 6. patients who anticipate taking longer than a one month break from treatment during the trial (i.e. 4 months from randomization).

Keywords: unexplained infertility acupuncture
effect of bright light on mood and sleep in parkinson's disease

Conditions: Parkinson's Disease; Depression

Summary: the purpose of this clinical trial is to investigate whether light therapy is a suitable treatment option for depression and insomnia in parkinson's disease.

the quality of life of patients with parkinson's disease and their caretakers is mainly influenced by so called non-motor symptoms. this includes neuropsychiatric consequences of the disease like depression and sleeping problems. the incidence of depressed mood in patients with parkinson is approximately 50%, the incidence for sleeping problems is 90%. these symptoms are often overlooked and even if recognized, inadequately treated. the treatment of mood and sleep disturbances in parkinson patients is hampered by adverse effects, incomplete responses to the usual treatments and the absence of specific treatment options for these symptoms in parkinson's disease. on the basis of the hypothesis of disturbed functioning of the suprachiasmatic nucleus in parkinson's disease it is expected that stimulation of this nucleus by bright light therapy will result in improved functioning on multiple different domains: mood, sleep, motor functions, quality of life and circadian rhythms. because there are virtually no side effects and the possibility of home treatment, light therapy is expected to be highly appreciated by the patients.

Eligibility criteria:
inclusion criteria: * parkinson's disease * depression exclusion criteria: * psychosis * mania * suicidality * retinopathy * previous light treatment * use of photosensitising medication

Keywords: parkinson's disease depression light therapy sleeping problems
effects of therapeutic neuroscience education in patients with chronic low back pain

Conditions: Chronic Low-back Pain

Summary: the study will be randomized controlled trail, subject diagnosed with low back pain meeting predetermined inclusion and exclusion criteria will be divided into two groups. pre assessment will be done using pain and disability as subjective measurement through numeric pain rating scale (nprs) \& modified oswestry disability index and the lumber range by goniometer as objective measurement. one group is subject will be treated with therapeutic neuroscience education and core stability exercise and second group is core stability exercise. each subject received 18 sessions with 3 treatments per week. post treatment values recorded after the session.after data collection from defined study setting,data will be entered and analyzed at riphah international university,lahore

chronic low back pain (lbp) is very common musculoskeletal disorders and leading causes of disability worldwide. numerous epidemiological data show that 11%-84% of people experience, have experienced,or will experience pain in the lower spine at least once in their lives . with a global prevalence of 9.4%, lbp was ranked highest in the number of years lived with a disability and sixth in overall burden of disease pakistan can suffer 56% from the lbp nociplastic pain can be mechanistically defined as pain arising from the altered function of pain-related sensory pathways in the periphery and cns, causing increased sensitivity nociplastic pain should be viewed as an overarching terminology that can be applied to a diverse range of clinical conditions that share common neurophysiological mechanisms. the main concern of tne concept is that increasing the patient feeling of biology and physiology underpinning their pain condition instead of focus on anatomy and structure issues of tissue.in order to improve health of patient with clbp healthcare provider proper educate their patient about experiencing pain and it may not result of tissue damage several non surgical treatments have been offered to help and decrease lbp, such as joint manipulation, traditional therapeutic exercises , and medication core stability training (cst) program this type of exercise focuses on the ability of the spine to stabilize in different positions and emphasize smaller, deeper, and posterior muscles. by increasing the endurance of these muscles, they retrain and maintain the correct physical condition to stabilize the spine to improve pain, performance, and rom there are few studies in literature which compare the tne effect with core stability exercisein clbp however there have been no studies which can compare tne with nociplastic pain which effects on clbp

Eligibility criteria:
inclusion criteria: * diffused chronic low back pain * stop movement due to fear of increasing pain * anxiety and sleep problem with clbp * symptoms duration most of days in 6 months * no treatment other than analgesics exclusion criteria: * diabetes mellites * radiating pain * spine surgery, fracture, arthritis

Keywords: back pain therapuetic neuroscience education range of motion
piezosurgical vs conventional exodontia surgery in healthy and patients with diabetes mellitus type 2

Conditions: Diabetes Mellitus, Type 2; Surgery; Tooth Extraction Status Nos

Summary: this study will evaluateand compare intraoperative and postoperative clinical parameters related to discomfort and wound heeling, as well as laboratory wound healing parameters after piezosurgical and conventional surgery approach during complex exodontia in healthy and patients with diabetes mellitus type 2


Eligibility criteria:
inclusion criteria: * multiple multi-rooted teeth indicated for extraction * controlled dmt2 exclusion criteria: * hba1c \>7% * chronic orofacial pain and infection in orofacial region * alcohol and tobacco consumption * pregnant women and nursing mothers

Keywords: piesosurgery exodontia diabetes mellitus
expanded access use of derazantinib for advanced intrahepatic cholangiocarcinoma (icca) with fgfr genomic alterations

Conditions: Intrahepatic Cholangiocarcinoma

Summary: basilea provided expanded access to derazantinib for patients with locally advanced, inoperable or metastatic intrahepatic cholangiocarcinoma (icca) with fgfr genomic alterations on a patient by patient basis while clinical development of derazantinib was ongoing.


Eligibility criteria:
the following inclusion criteria were applied: * all other treatment options had been exhausted * patient was ineligible for any ongoing trials or was geographically inaccessible to trials including a trial with derazantinib * there was a reason to believe that the potential benefit of receiving derazantinib outweighs the risk of treatment with an investigational drug product * patient was willing and able to provide written informed consent * if applicable, regulatory approval by the appropriate jurisdiction was obtained

Keywords: intrahepatic cholangiocarcinoma icca metastatic cholangiocarcinoma fgfr genomic alteration biliary cancer bile duct cancer liver cancer