Kornimate/medical-research-clean huggingface dataset:
movement quality and balance improvement in people with chronic low back pain following trunk muscle training

Conditions: Chronic Low Back Pain (CLBP)

Summary: the goal of this project is to assess if chronic low back pain (clbp) participant's movement quality and balance variables can change after training that decreases their pain and disability. it will also compare the difference between structural exercise (se) and isolated trunk exercise (ite). the main questions it aims to answer are: 1. what are the effect of the training on the participant's movement quality and balance. 2. what are the difference between different types of trunk muscle training on people with clbp. researchers will compare se, ite and control. control group will receive back school education that was shown not to be effective in reducing pain and disability. participants will: 1. do home and in-lab based se or ite training, or maintain active daily living over 2 months. 2. complete the pain and disability questionnaire and do several physical functioning tests while having their trunk and lower limb movement and muscle activation measured.

both ite and se training are equalized in terms of training intensity based on rate of perceived exertion, training duration per session, training frequency, and intervention period. training intensity measurement does not use other methods of quantification as ite training does not increase heart rate or blood lactate significantly regardless of the intensity.

Eligibility criteria:
inclusion criteria: * body mass index (bmi) 18-25 kg/m2 * experiencing intermittent pain lasting at least 3 months * had oswestry disability index (odi) score ranging between 17% and 45%. exclusion criteria: * exercise contraindication based on physical activity readiness questionnaire * indication or diagnosis of other chronic diseases (such as cancer, cardiovascular disease, diabetes, bone fracture, or infection) * artificial lower limb joints, history of spinal surgery, walking aid use * personal mobility restrictions (due to connective tissue diseases, rheumatoid arthritis, or central nervous system disorders) * pregnancy or within 1 year post partum

Keywords: movement quality balance trunk muscle training
evaluation of the health related quality of life and disease prevalence of children from spain at 6-8 years of age who participated in a qualifying infant formula study at birth

Conditions: Quality of Life

Summary: the purpose of this study is to evaluate the influence of the type of feeding in the first year of life on the behavior and health-related quality of life at 6-8 years of age.


Eligibility criteria:
inclusion criteria: * father, mother or legal representative of a child who was included in the qualifying study * child 6 - 8 years of age * written informed consent of the father, mother or legal representative exclusion criteria: * none
thromboprophylaxis after surgery for gynecologic malignancy in china

Conditions: Gynecologic Neoplasms; Venous Thromboembolism; Low Molecular Weight Heparin; Argatroban

Summary: venous thromboembolism (vte) is an important cause of post-operative morbidity and mortality in women undergoing surgery for gynecologic malignancies. although the benefit of thromboprophylaxis in reduction of post-operative vte events after surgery for gynecologic cancers has been well documented around the world, the evidence for chinese women is rare. the investigators designed this prospective and randomized study to assess the benefit of pharmacologic prophylaxis for patients received surgical treatment for gynecologic malignancies in china.


Eligibility criteria:
inclusion criteria: * patients of ovarian cancer, cervix cancer or endometrial cancer; * age ≤ 70 years; female, chinese women; * initial treatment is surgery; * laboratory tests: wbc ≥ 4×10(9)/l, neu ≥ 2×10(9)/l, plt ≥ 100×10(9)/l, serum bilirubin ≤ 1.5 times the upper limit of normal, transaminase ≤ 1.5 times the upper limit of normal, bun, cr ≤ normal * no prior pharmacologic prophylaxis; * provide written informed consent. exclusion criteria: * plt ≤ 75×10(9)/l * vascular injury * history of thrombosis * liver and kidney dysfunction * concurrently participating in other clinical trials * unable or unwilling to sign informed consents; * unable or unwilling to abide by protocol.
waitlist-control trial of smartphone (app-based) cbt for social anxiety disorder (sad)

Conditions: Social Anxiety Disorder

Summary: the investigators are testing the efficacy of smartphone-delivered cognitive behavioral therapy (cbt) treatment for social anxiety disorder (sad). the investigators hypothesize that participants receiving app-cbt will have greater reduction in lsas scores than those in the waitlist condition at treatment endpoint (week 12).

the primary aims of this study are to test the efficacy of a smartphone-based cbt treatment for adults with sad recruited nationally. eligible subjects (n=80) will be randomly assigned to 12 weeks of smartphone-delivered cbt for sad either immediately, or after a 12-week long waiting period (50-50 chance). the investigators hypothesize that smartphone-delivered cbt for sad will be feasible and acceptable to individuals with sad, and that it will lead to greater reductions in sad symptom severity compared to the passage of time (waitlist control).

Eligibility criteria:
inclusion criteria: * at least 18 years of age * current diagnosis of primary dsm-5 sad, based on mini * currently living in the united states exclusion criteria: * psychotropic medication changes within 2 months prior to enrollment i. participants taking psychotropic medication must have been on a stable dose for at least 2 months prior to enrollment and not change medication during study period * past participation in ≥ 4 sessions of cbt for sad * current severe substance use disorder * lifetime bipolar disorder or psychosis * current severe comorbid major depression, as indicated by clinical judgment and/or a qids-sr total score ≥ 21 \*\*\*edit\*\*\* * acute, active suicidal ideation as indicated by clinical judgment and/or a score ≥ 2 on the suicidal ideation subscale of the c-ssrs * concurrent psychological treatment * does not own a supported mobile smartphone with a data plan * lack of technology literacy that would interfere with ability to engage with smartphone treatment
xbox in the rehabilitation of chronic traumatic brain injury

Conditions: Traumatic Brain Injury; Balance Disorders; Attention Deficits

Summary: traumatic brain injury is an extremely common disease, it counts 50.000 deaths and 235.000 hospitalizations every year. functional consequences of an acquired brain injury have a considerable impact on quality of lives of patients and care-givers with direct effects on balance, mobility and on psycho-social functions. attention deficits are one of the most frequent and disabling consequences of severe brain injury. within the wide spectrum of attentive problems, patients with traumatic brain injury frequently have shown difficulties in divided attention. patients, care-givers and professionals frequently refer difficulties also in selective attention and vigilance as consequence of the trauma. it has been shown how these difficulties are tightly related with the missed return to work after two years from the injury. the hypothesis of this study is to investigate the feasibility of a rehabilitative protocol on gaming using the console xbox and its efficacy in improving balance, mobility, risk of falling, attentive functions (selective and divided attention) in subjects which have had a traumatic brain injury at least 12 months before.

inclusion criteria: chronic traumatic brain injury (\>12 months) age\>18, \<70 years old presence of a moderate balance deficit identified by cb\&m with a score \< 65 or presence of a selective attention and shifting attention deficit identified by the tea computerized battery (tau\<37).

Eligibility criteria:
inclusion criteria: * chronic traumatic brain injury (\>12 months) * age\>18, \<70 years old * presence of a moderate balance deficit identified by ubs with a score\>15 and \< 60 or presence of a selective attention and shifting attention deficit identified by the tea computerized battery (tau\<37). exclusion criteria: * neurologic diseases associated with possible involvement of motor functions * medical conditions that could interfere with the safe conclusion of the study protocol * severe cognitive-behavioural diseases (lcf\<6), * severe psychiatric diseases * use of walking aids

Keywords: traumatic brain injury (tbi) balance disorders attention deficits x-box gaming virtual reality
a study to assess the effect of cellcept (mycophenolate mofetil) and reduced corticosteroids in patients with active pemphigus vulgaris (pv)

Conditions: Pemphigus Vulgaris (PV)

Summary: this study was designed to assess the efficacy and safety of cellcept (1 g or 1.5 g orally twice daily for 52 weeks) in patients with pemphigus vulgaris receiving prednisone or other corticosteroids. during the study, patients had their corticosteroid dose gradually reduced if they responded to treatment. the anticipated time on study treatment was 12 months, and the target sample size was \<100 individuals.


Eligibility criteria:
inclusion criteria: * adult patients 18 to 70 years of age * diagnosis of mild to moderate pemphigus vulgaris within the past 12 months, requiring high dose corticosteroids exclusion criteria: * female patients who are pregnant, breastfeeding, or lactating * regularly scheduled plasma exchange (pe) or intravenous immunoglobulin (ivig) treatment, or pe or ivig treatment within 8 weeks prior to randomization * cellcept or other immunosuppressive therapy, except corticosteroids, exceeding 2 weeks total duration and within 8 weeks prior to randomization * use of pv therapies other than those noted above, within 4 weeks prior to randomization * use of topical corticosteroids within 2 weeks prior to randomization
peri-operative monitoring of cerebral oxygenation and the onset of delirium in patients undergoing cardiac surgery

Conditions: Delirium

Summary: delirium is an acute brain syndrome characterized by a disturbance in consciousness accompanied by periods of inattention and changes in cognition. memory impairment, irrelevant speech and disorientation are commonly observed signs and symptoms. episodes of delirium have been associated with a prolonged hospital stay, functional and cognitive dysfunction and even an increased mortality. delirium is a common complication in the postoperative setting where the incidence increases with the risk of surgery. the estimated incidence of postoperative delirium after cardiovascular surgery is remarkable, ranging from 31% up to 51%. diverse preoperative risk factors have been documented for patients undergoing cardiac surgery: age, pre-existing cognitive dysfunction, a history of alcohol abuse and the severity of illness at admission. an early diagnosis of postoperative delirium is of great importance to prevent long-term cognitive impairment. for this purpose, a highly specific diagnostic monitoring tool should be implemented during perioperative cardiac surgery care. near infrared spectroscopy (nirs) provides information on brain oxygenation by quantifying the regional cerebral oxygen saturation (scto2) at the microvascular level. recently, two studies showed that preoperative cerebral tissue oxygenation was lower in the cohort of patients that developed delirium postoperatively. nevertheless, these studies did not investigate whether the onset of postoperative delirium coincided with a change of postoperative scto2. a relationship between delirium and reduced cerebral blood flow has already been suggested. as such, the occurrence of a postoperative decrease of scto2 might have been overlooked thus far. hence, investigators want to conduct a prospective, interventional study to determine the relationship between postoperative scto2 and the onset of delirium after cardiac surgery.


Eligibility criteria:
inclusion criteria: * adult patients (age ≥ 70 years) undergoing elective on-pump cardiac surgery (i.e. valve replacement with or without coronary artery bypass graft surgery (cabg)) * surgery has to be performed under normothermic conditions * ability to perform the confusion assessment method for the intensive care unit (cam-icu) * patients willing to provide written informed consent exclusion criteria: * age \< 70 years * off-pump cardiac surgery * surgery performed under hypothermic conditions * duration before extubation \> 36 hours * patients with insufficient knowledge of the dutch language * patients using antipsychotics * patients with a known history of alcohol abuse (consuming two or more units a day)

Keywords: aortic valve replacement with or without cabg
"patient reported outcome after dislocation of a primary tha"

Conditions: Quality of Life; Hip Dislocation

Summary: the aim is to compare qol and hip specific outcome measures in patients with a single or recurrent episode(s) of tha dislocation and patients with a tha without any dislocation.

knowledge about the patient's own perception of both general health and more hip-related issues after experiencing a hip dislocation is lacking (19). hip surgeons need this information in order to incorporate it with other objective aspects, when advising patients with their first hip dislocation. due to the large study population, this study will provide solid information of what to expect after a hip dislocation and be the largest study ever conducted within this topic. depending on the results, this study may change the path we choose to advise for our patients after single or recurrent dislocations. a matched case-control study involving the share of tha patients with at least 1 episode of hip dislocation. the patients had undergone primary surgery in the 5-year period from 01.01.2010 - 31.12.2014 and subsequent dislocation was evaluated in a 2-year follow-up period. given a 3-5% approximated incidence of dislocation, 1100-1800 cases will have been identified. patients are subdivided in groups depending on the number of dislocations and one group containing tha revisions. in order to be included, a time frame of at least 0,5 year since the last episode of dislocation or surgery must have passed. a matched control group of patients with primary tha without any event of dislocation are located from the original 5-year period of primary surgery. they will be matched with the group of patients with dislocation, regarding to: 1. age (+/- 5 years) 2. gender 3. date of surgery and hospital the study will be conducted in accordance with the strengthening the reporting of observational studies in epidemiology (strobe) guidelines. after 01.01.2019, all patients included will be receiving 3 questionnaires (a generic - eq-5d, a hip-specific - hoos, and an activity scale - ucla) by e-boks (a mandatory secure email system couplet to the patient's cpr number). some elderly are exempt and will instead receive the questionnaires by regular mail and a pre-labeled return envelope is attached. reminders are sent after 2 months.

Eligibility criteria:
inclusion criteria: * patients with one or more events of hip dislocation after a primary tha * controls with a primary tha without events of hip dislocation exclusion criteria: -
effects of laser therapy and exercise in participants with chronic low back pain

Conditions: Low Back Pain (LBP)

Summary: the objective of this clinical trial is to evaluate the additional effects of laser therapy in participants with chronic non-specific low back pain in the short and long term.

the objective of this clinical trial is to evaluate the additional effects of photobiomodulation therapy in participants with chronic non-specifc low back pain in the short and long term.

Eligibility criteria:
inclusion criteria: * patients with non-specific chronic lbp, defined as pain or discomfort between the costal margins and inferior gluteal folds with or without referred pain to the lower limbs; * persistent lbp for at least 3 months; * low back pain of intensity reported 3 or higher by the visual analogue scale (vas), at least once in the previous 7 days; * aged between 18 and 65 years; * both genders. exclusion criteria: * patients with severe skin diseases (eg, skin cancer, erysipelas, severe eczema, severe dermatitis, severe psoriasis and severe hives lupus); * participants with known or suspected serious spinal pathology (e.g., fractures, tumors, inflammatory, rheumatologic disorders, or infective diseases of the spine); * nerve root compromise; * history of previous spinal surgery (even in a segment other than the lumbar spine) or scheduled surgery; * pain due to or associated with pregnancy or structural deformity (for example, scoliosis); * pregnancy; * comorbid health conditions that could prevent active participation in the exercise programs such as high blood pressure, pregnancy, or cardio-respiratory illnesses; * having answered "yes" to any of the questions in the physical activity readiness questionnaire (par-q); * be treated with pbmt; * being under physiotherapeutic treatment or perform physical exercise; * who are using nsaid or start it during the trial; * who have inability to tolerate the proposed experimental procedures (such as tests of mobility and strength of the lumbar muscles).
safety & efficacy of epo-018b for the treatment of anemia in participants with ersd receiving maintenance hemodialysis

Conditions: Chronic Renal Failure; Anemia

Summary: the purpose of this study is to evaluate the safety,efficacy, pharmacodynamics (pd), and pharmacokinetics (pk) of multiple intravenous doses of epo-018b in participants with chronic kidney disease (ckd) who are on hemodialysis.


Eligibility criteria:
inclusion criteria: 1. males or females\>=18 and≤65. 2. receiving dialysis for at least 2 weeks before the first study dose. 3. patients who have not received any erythropoietic agents within 6 weeks prior to the first study dose. 4. two hemoglobin values of ≥ 6.0 and \< 10.0 g/dl at screening 5. patients with a transferrin saturation ≥ 20% or a ferritin≥ 100 ng/ml. vitamin b12 and folic acid level above lower limit of normal. 6. signed informed consent. exclusion criteria: 1. pregnant or lactating females. 2. red blood cell transfusion within 3 months prior to study drug administration. 3. known intolerance to any erythropoiesis stimulating agent (esa) or pegylated molecule or to all parenteral iron supplementation products. 4. hemolytic syndromes or coagulation disorder. 5. hematological disease (including but not limited to myelodysplastic syndrome, hematological malignancy, , hemoglobinopathy, pure red cell aplasia). 6. chronic, uncontrolled, or symptomatic inflammatory disease (e.g., rheumatoid arthritis,systemic lupus erythematosus, etc.). 7. c reactive protein (crp) level greater than 30 mg/l within the 4 weeks prior to study drug administration. 8. uncontrolled or symptomatic secondary hyperparathyroidism，ipth\>500pg/ml. 9. poorly controlled hypertension within 2 weeks prior to study drug administration, per investigator's clinical judgment (e.g. systolic ≥ 160mm hg, diastolic ≥ 100 mm hg). 10. chronic congestive heart failure (new york heart association class iv). 11. significant symptom within 6 months prior to study drug administration (e.g. myocardial infarction, serious or precarious coronary artery disease,stroke, respiratory disease, autoimmune disease, neuropathy, phrenopathy, hepatopathy including active hepatitis b, active hepatitis c, or alt\> 2 x upper limit of normal (uln), ast\> 2 x upper limit of normal (uln) , etc.). 12. a positive test for hiv antibody. 13. tumor malignancy 14. expected survival less than 12 months, 15. a scheduled kidney transplant 16. major surgery (may massive bleeding) during the study 17. expected conception within 4 weeks after the end of the study treatment 18. the subject has participated in other clinical trial within the 6 weeks prior to study drug administration 19. have any other condition or prior therapy that, in the investigator's opinion, would make the subject unsuitable for the study, or unable or unwilling to comply with the study procedures.
percutaneous electrical stimulation on radial nerve in patients with lateral epicondylalgia

Conditions: Lateral Epicondylitis

Summary: lateral epicondylalgia is a common musculoskeletal condition that approximately affects 1-3% of the general population. several authors have found greater mechanical pain sensitivity in the radial nerve when compared with healthy subjects. radial tunnel syndrome exhibits a similar clinical presentation to lateral epicondylalgia. percutaneous electrical stimulation has shown reduce pain in several conditions. percutaneous electrical stimulation on the radial nerve could cause an important relief in lateral epicondylalgia. hypothesis: percutaneous electrical stimulation on radial nerve plus exercise therapy in patients with lateral epicondylalgia is better than sham percutaneous electrical stimulation plus exercise.

randomized, double-blind, placebo controlled clinical trial, using percutaneous electrical nerve stimulation (pens). pens is technique to provide a transcutaneous electrical nerve stimulation current throughout needling filaments place close to the nerve. study aims: aim #1: the primary aim of the study is to compare the effect of the immediate, short, medium and long-term of pens on intensity of pain as measured by visual analogue scale (vas) in patients with lateral epicondylalgia with random assignment to two treatments: pens plus exercise program or sham pens plus exercise program. aim #2: the secondary aim of the study is to compare the effect of the immediate, short, medium and long-term of pens on pain free grip strength, disability as measured by patient rated tennis elbow evaluation (prtee) and dash questionnaire and pressure pain threshold (ppt) and area and distribution of pain in patients with lateral epicondylalgia with random assignment to two treatments: pens plus exercise program or sham pens plus exercise program, and determine if psychological factors (fear and avoidance and catastrophism) change with any of the treatments and if is related with the primary and secondary outcomes.

Eligibility criteria:
inclusion criteria: * lateral epicondylalgia symptoms confirmed with at least 2 of the 4 following test: 1. pain during palpation of lateral epicondyle 2. pain on resisted wrist extension 3. pain on resisted middle finger extension 4. pain during hand-grip. exclusion criteria: * history of fractures, luxations, surgery and/or musculoskeletal disorders in upper limb. * neurological disorders, inflammatory and/or degenerative diseases. * having received as treatment techniques that involve needles on the previous 6 months to study enrollment, or having received percutaneous electrical stimulation as a treatment before. * cervical pathology, fibromyalgia, unstable cardiovascular diseases, pregnant women or under suspect of pregnancy. * contraindications of needle's insertions: anticoagulant therapy, needle phobia, diabetes, hypothyroidism, lymphoedema, muscular diseases). * contraindications of electrical current application.

Keywords: tennis elbow lateral epicondylalgia lateral elbow tendinopathy lateral elbow pain percutaneous electrical stimulation