Kornimate/medical-research-clean huggingface dataset:
study to investigate the effectiveness of a food supplement made of hop in the improvement of menopausal symptoms

Conditions: Menopause

Summary: this observational study will assess the effects of a dietary supplement based on humulus lupulus l. to relieve the symptoms of menopause in perimenopausal and postmenopausal women, by doing a follow up of the cervantes scale and the anxiety and depression goldberg scale in a period of 6 months. participants will be allocated to dietary supplement being the difference between groups if they are perimenopausal or postmenopausal, and will attend to 3 visits (baseline, 3 months and 6 months).


Eligibility criteria:
inclusion criteria: * perimenopausal according to the stages of reproductive aging workshop (straw) or postmenopausal women between the ages of 40 and 60. * having moderate or severe hot flushes. * accepting and signing the informed consent. exclusion criteria: * women unable to answer the questionnaires. * women being treated with sulfonamides, methotrexate, triamterene, sulfasalazine, estrogens, phenytoin, anxiolytics, antidepressants, daily multivitamins, hormonal therapy, use of oral contraceptives in the last 3 months, herbal products to reduce vasomotor symptoms in the last months. * women in treatment and control for psychiatric pathology. * women with any comorbidity that could be the cause of a symptomatology coinciding but not bound to peri or post-menopause. * women diagnosed or with clinical suspicion of breast cancer, endometrium or other hormone-dependent tumors, genital tract bleeding, actives thromboembolic disorders, active gall bladder illness or being lactose intolerant. * women being treated with antithyroid medications and other drugs like letrozole, raloxifene, bazedoxifene, bethanechol, desmopressin and calcitonin or other drugs that at investigators judgement could interfere in the study's result. * use of dietary supplements that include phytoestrogens (drinks or desserts based in soya) in the last month. * women with coronary diseases, strokes or chronic renal diseases, type 2 diabetes, deep vein thrombosis or pulmonary embolism.
to compare the safety and efficacy of balloon occluded/plug assisted retrograde transvenous obliteration with endoscopic variceal obturation for primary prophylaxis of gastric varices with large spontaneous shunt

Conditions: Liver Cirrhosis

Summary: study population: all the consecutive patients of cirrhosis who are diagnosed to have large gastric varices without prior history of bleeding from gv, who came to opd or endoscopy in hepatology department of ilbs will be evaluated for inclusion. study design: prospective interventional study. the study will be conducted in the department of hepatology ilbs. study period: 1.0 years sample size: 42


Eligibility criteria:
inclusion criteria: 1. age 18-75 years 2. cirrhotic patients, with gv (gov2 or igv1) with eradicated or small low risk esophageal varices with gastrorenal shunt of \>10 mm size amenable for brto/parto. exclusion criteria: 1. non-cirrhotic portal hypertension, 2. history of bleeding from gv 3. hepatic encephalopathy grade iii/iv, 4. acute kidney injury 5. patients on beta blocker therapy for \> 6 months prior to enrollment in study 6. hepatocellular carcinoma 7. portal venous thrombosis 8. presence of jaundice (bilirubin \>3 mg/dl), ascites, child c, meld \> 18 9. advanced cardiac or pulmonary diseases 10. pregnancy 11. patients not giving informed consent
the missouri health literacy and diabetes communication initiative

Conditions: Diabetes Knowledge

Summary: objective: to evaluate the efficacy of the american college of physicians foundation (acpf) diabetes guide (living with diabetes: an everyday guide for you and your family) to improve diabetes self-management. study sites: nine federally-qualified health centers or safety-net clinics at three sites in missouri. sites are urban (st. louis), midsize (columbia) and rural (kirksville). three fqhcs or safety net clinics are located at each of the sites. methods overview and design: a randomized controlled trial will be conducted. patients will be recruited from identified health centers. as the intervention itself is directed to the clinic and not patient, the clinics will be randomly assigned to either 1) usual care (no treatment), 2) "carve-in" - patients receive the diabetes guide and clinic staff follow-up and work with patients to create and complete action plans or 3)"carve-out" - patients receive the diabetes guide and a diabetes educator in chicago follows up and works with patients to create and complete action plans. recruited subjects will be administered a baseline assessment, and 3-month and 1-year follow-up assessments. sample: the investigators will recruit a total of 1,080 patients (n=120 per clinic) anticipating 80 percent retention through both follow-up assessments (final estimated number of patients = 720). eligibility to participate will be defined as patients 1) ages 30 and older (to better represent disease distribution), 2) english or spanish-speaking, 3) a confirmed (by chart) diagnosis of uncontrolled diabetes (hba1c 7.0 or more).


Eligibility criteria:
inclusion criteria: * uncontrolled diabetes patients (defined as hba1c 6.0 or greater). * 25 years or older * english or spanish speaking exclusion criteria: * uncorrectable hearing or visual impairment * moderate to severe cognitive deficits

Keywords: changes in hba1c
impact of probiotics in modulation of intestinal microbiota

Conditions: Colorectal Cancer

Summary: the investigators would study about impact of the administration of probiotics in the intestinal mucosa of patients undergoing resection colic, by evaluating cytokine profile by quantitative real time pcr. the investigators believe that patients who use probiotic preoperative would provide cytokine profile less inflammatory than those of the control group.

samples of colorectal cancer-free mucosa derived from patients who underwent surgical resection were investigated. quantitative real-time polymerase chain reaction (rt-qpcr) was used to determine expression levels of the following genes: il10, il1b, il23a, tnf, il12b, infg, il17a.

Eligibility criteria:
inclusion criteria: * if he or she were older than 18 years * intended to undergo elective crc resection at ufmg hospital exclusion criteria: * patients were excluded if they were not able to receive the probiotics seven days before the operation * if colon resection was not performed due to changes in operation strategy, or if they discontinued probiotic use on their own or * if they removed their consent.

Keywords: probiotics colorectal cancer postoperative infection immune function bacterial translocation gastrointestinal surgery
controlled exposure to diesel exhaust in subjects with allergic rhinitis

Conditions: Allergic Rhinitis

Summary: proximity to traffic, particularly to diesel-powered heavy-duty vehicles, has been associated with inducing and enhancing allergies in children and adults. to investigate the basis for this association, a controlled exposure of allergic rhinitics to diesel exhaust was performed at a dose known to be pro-inflammatory in healthy individuals. the hypothesis was that airway inflammation would be augmented in allergic rhinitics following exposure to diesel exhaust at an environmentally pertinent particulate matter concentration. fourteen allergic rhinitics were exposed in a double-blinded, randomised trial to both diesel exhaust at 100 microgram/m3 pm10 (representing an aerosol of nanoparticulate combustion particles, mean diameter 80 nm) and filtered air for two hours on separate occasions. bronchoscopy with endobronchial mucosal biopsies and airway lavage was performed 18 hours post-exposure, and samples were analysed for markers of inflammation.


Eligibility criteria:
inclusion criteria: * history of seasonal allergic rhinitis requiring medical treatment only during the pollen season and were classified as mild and intermittent according to aria guidelines. * positive skin prick test to airborne allergens * normal lung function * negative metacholine challenge exclusion criteria: * current smoking or a previous history of smoking. * asthma * chest infection within six weeks prior to or during the study * current use of non-steroidal anti-inflammatory drugs * current vitamin c or e supplementation * current use of topical nasal steroids.

Keywords: particulate matter air pollution diesel exhaust allergic rhinitis
retrospective comparative in vitro case-controlled study of the liquid biopsy test system in women with breast cancer

Conditions: Breast Neoplasm Female

Summary: proof of concept retrospective study. women who have the diagnosis breast cancer ( confirmed by biopsy) will donate a blood samples. tubes with blood will be transferred to the sponsors laboratory and arna breast test will be performed. the result of test will be compared with the biopsy result for each person.


Eligibility criteria:
inclusion criteria: * availability of signed and dated informed consent. * women from 35 to 65 years old, who are generally healthy, with confirmed breast cancer. or without any neoplasms in breast (control group) * presence of a documented biopsy * presence of mammography, ultrasound or mri of the mammary glands no later than three months. exclusion criteria: * pregnancy. * any other cancers diagnosed now or previously, with the exception of breast cancer. * therapy with cytostatic during the last three months. * chemotherapy within the past three months. * therapy with hormonal drugs, including all forms of contraceptive drugs. * therapy with other prohibited groups of drugs. * systolic blood pressure \> 180 mm hg. and / or diastolic blood pressure \> 120 mm hg. with repeated measurements. * simultaneous participation in another clinical study. * relative affiliation to the clinic, for example, the patient is a close relative of the researcher or a dependent person (for example, a clinic employee or student or a sponsor employee). * a clinically significant condition or laboratory result that, in the opinion of the investigator, threatens the safety of the test subject, may interfere with assessments, or prevent the completion of the study. * failure to cooperate to participate in planned procedures, including the following examples: lack of understanding of language, mental illness, inability to visit the clinic. * diseases or conditions that may affect the conduct of the study or the interpretation of the results. * history of organ transplantation. * blood transfusions within the last 6 months.
feasibility evaluation of a self-guided digital tool for problematic alcohol use

Conditions: Alcohol Consumption

Summary: the purpose of the study is to evaluate the feasibility of a new monitored self-guided digital intervention based on an alcohol diary and techniques from cognitive behavioral therapy and relapse prevention. the participants will be adults with problematic alcohol use. an uncontrolled trial will explore participant's usability and treatment credibility ratings, behavioural engagement and preliminary effects on alcohol use.


Eligibility criteria:
inclusion criteria: 1. ≥ 18 years of age 2. access to internet 3. ≥8 points for men and ≥6 points for women on alcohol use disorders identification test (audit) exclusion criteria: 1. insufficient knowledge of the swedish language 2. difficulties reading or writing related to a digital intervention. 3. other ongoing psychological treatment with a content similar to that in the current study (problematic alcohol use). 4. high suicide risk based on telephone assessment. 5. other urgent need for more intensive psychiatric care, or addiction care services, based on telephone assessment.
pilot evaluation of the cynosure potenza™ system for treatment of cosmetic dermatologic skin conditions

Conditions: Wrinkles; Scars; Stretch Marks; Pigmentation; Skin Laxity

Summary: the primary objective of this pilot study is exploratory investigation evaluating the potenza microneedle fractional radiofrequency (rf) device and may be used in combination with the icon intense pulsed light (ipl) device.


Eligibility criteria:
inclusion criteria: * healthy male or female 18 years of age or older. * presence of unwanted dermatologic condition suitable for treatment such as facial and/or neck wrinkles, skin laxity of face, neck or body, scars, acne scars or striae, or vascular and/or pigment dyschromia * ability to read, understand, and sign the informed consent form * understands and accepts the obligation not to undergo any other procedures in the areas to be treated and/or weight loss through the follow-up period. * willing and able to comply with all study participation requirements including returning for follow-up visits and abstaining from exclusionary procedures for the duration of the study exclusion criteria: * is pregnant or of childbearing potential and not using (or willing to use) medically effective birth control, or has been pregnant in the last 3 months, currently breast feeding or planning a pregnancy during the study. * presence of an active systemic or local skin disease or condition that may affect wound healing or interfere with participation. * history of keloids or poor wound healing * taking medication which is known to increase sensitivity to sunlight * has a seizure disorders triggered by light * cancer, malignant disease, skin pathology, condition or allergic reactions that could interfere with evaluation or with the use of typical ancillary medical treatments or care used before, during or after treatments * history of collagen, vascular or immunosuppressive or deficiency disorders * history of coagulative disorder or use of anticoagulant drugs within 2 weeks of study treatment * use of steroids within 2 weeks of study treatments * use of accutane (isotretinoin) in the past 12 months * previous surgical or cosmetic procedure to the target area in the last 6 to 12 months that could interfere with the treatment procedure and affect treatment outcome * has an implanted pacemaker or defibrillator, metal pins or prosthetic joints * allergic reaction to gold metal * receiving or have received gold therapy * photo-sensitive skin * psycho-neurotic condition including alcohol or drug abuse * unwilling or unable to adhere to all study requirements for treatment and follow-up * has any condition or is in a situation which in the investigators opinion may put the subject at significant risk, may confound study results or may interfere significantly with the subject's participation.
the effectiveness of virtual reality in the management of procedural anxiety and pain in children suffering from chronic pathologies or burn injuries.

Conditions: Anxiety; Chronic Disease; Pain

Summary: single-center, randomized, controlled clinical trial (rct) to evaluate the efficacy of vr on pain and anxiety in children with chronic diseases undergoing painful procedures in an outpatient or day hospital setting


Eligibility criteria:
eligibility criteria: inclusion the study population includes children who meet the following criteria: 1. diagnosis of a chronic condition, aged 3 to 18 years, without visual impairments or cognitive deficits, and with a confirmed diagnosis of the condition. 2. children receiving care in the wound care nursing clinic or medical day hospital (dh) who require minimally invasive painful procedures. 3. assent and informed consent provided by both the children and their parents. 4. children with chronic conditions that do not inherently cause chronic pain, which could alter pain perception (e.g., rheumatoid arthritis, diabetic foot, muscular dystrophy). 5. children able to understand and communicate in italian or english. 6. parents able to understand and communicate in italian or english. eligibility criteria: exclusion children with the following characteristics will be excluded from the study: 1. chronic condition not yet diagnosed. 2. use of eyeglasses, presence of amblyopia or monocular vision. 3. chronic pain, which could distort pain perception during the procedure. 4. use of analgesic therapy within the last 8 hours, which could bias data collection results (the only prohibited therapy in the study and a reason for exclusion). 5. cognitive impairment preventing the proper use of assessment scales.

Keywords: virtual reality chronic pain paediatric chronic disease
efficacy of morning-only bowel preparation for afternoon colonoscopy.

Conditions: Colon Cancer

Summary: the study aims to study the adequacy of bowel preparation (colon cleansing) for afternoon colonoscopies. the conventional regimen of giving bowel prep on the evening prior to the day of the colonoscopy will be compared with that given on the morning of an afternoon colonoscopy. endoscopist scoring the bowel cleansing efficacy with an ottawa scale are blinded to the randomization process.

two bowel preparation regimens of polyethylene glycol (peg), commonly referred to as "golytely" will be tested for their efficacy (bowel cleansing effect) and patient tolerability. the goal is to reduce the failure rates of afternoon colonoscopies, for which, one of the main reasons attributed is inadequate bowel preparation. for the afternoon colonoscopies, the conventional peg regimen given on the evening prior to the day of the colonoscopy will be compared with the novel peg regimen given on the morning of the day of the colonoscopy. the comparison will be drawn for two measures - bowel cleansing effect measured from the questionnaire given to the gastroenterologists performing the colonoscopy and the patient tolerability evaluated from the information gathered from the patient's questionnaire.

Eligibility criteria:
inclusion criteria: * all patients attending the gi clinic at ccf who are prescribed colonoscopy and are willing to get the procedure done in the afternoon. exclusion criteria: * colonoscopy is contraindicated * prior colectomy or colon surgery.

Keywords: afternoon colonoscopy morning evening bowel preparation efficacy satisfaction
visual exploration and attention: studies in patients with schizophrenia and autism spectrum disorders

Conditions: Autism Spectrum Disorders; Schizophrenia

Summary: the aim of the protocol is to better understand the impairments in visual processing, as such impairments may induce social interaction difficulties in subjects with autism spectrum disorders (adults and children) and schizophrenia, like face exploration.the same protocol will be used for the three populations, each population being compared with matched controls. the explorations are designed to test two different hypotheses regarding the mechanisms of the visual perception difficulties of the two populations. even though difficulties to extract the global form of objects have been described in both subjects with autism and schizophrenia, we will test two different hypotheses for the two populations. we will test the hypothesis that subjects with autism display an advantage for the processing of local information arising at an early level of processing, whereas disorders observed in patients with schizophrenia originate from attention disorders. the protocol includes three consecutive studies, each one being applied in each of the three populations.


Eligibility criteria:
inclusion criteria: * iq above 70, as evaluated with the wais iii in adults and with the wisc in children * signed consent * dsm iv criteria in case of autism spectrum disorders or schizophrenia exclusion criteria: * grave or non stabilized somatic pathology * pathology affecting the central nervous system; other than the studied pathologies * intake of psychotropic drug, except for patients * invalidating sensory processes

Keywords: visual perception local/global processing attention visual priming collinearity grouping
quality of life and functional capacity in post intensive care unit

Conditions: Post-intensive Care Syndrome

Summary: background. staying in an intensive care unit can lead to physical and cognitive complications and post-traumatic stress. currently, the aim is to find out the level of quality of life, functional capacity and cognitive status post intensive care unit. describe the evolution of the quality of life, functional capacity and cognitive status of a cohort of patients admitted to the ward room after discharge from the intensive care unit, with subsequent follow-up at 3, 6 and 12 months of his discharge. methods. prospective, observational, analytical cohort study. subjects over 18 years of age with at least 48 hours of confinement in a closed area were included. demographic variables, quality of life, functional capacity and cognitive status were recorded. a telephone follow-up was carried out three, six and twelve months after institutional discharge. for the evaluation of the primary variables, euroqol 5d-5l (eq5d - eq5d-vas), barthel index and fototest were used.


Eligibility criteria:
inclusion criteria: * all patients over 18 years old * at least 48 hours in the icu * who subsequently entered the clinical ward room * who signed the informed consent exclusion criteria: * those patients who received invasive mechanical ventilation in the last 6 months * who had been admitted to an icu in the last 6 months * patients who cannot answer the questionnaires on their own or who do not have relatives to answer them * patients with progressive degenerative neurological pathology. * patients diagnosed with cancer with a life expectancy of less than 12 months according to the criteria of the oncologist.
effect of deep breathing exercises in smokers

Conditions: Healthy Smokers

Summary: to determine the effect of deep breathing exercises on lung function in healthy smokers.

the purpose of the study to determine the effect of deep breathing exercise in smokers because deep breathing improve the lung capacity by filling the lung with the oxygen and improve the pulmonary function, it also reduce the stress and anxiety level by slowing down the pace of your whole body and therefore promote general relaxation and improve the quality of life in smokers, muscular activity or physical activity is also increased because by deep breathing maximum oxygen is reached to every muscle and they get nourish well so overall impact of deep breathing exercise is positive. deep breathing exercise technique offered in the study are easy to learn and can be performed by everyone and everywhere safely, because there is no complex and pain full procedure. so deep breathing exercise have been proposed as a way of combating cigarette craving, improves quality of life and lung function.

Eligibility criteria:
inclusion criteria: young male and female adults with age group of 20-30 years without any chronic complication doing smoking from past five years are included in this study as the basic purpose of the study is to determine the effects of deep breathing exercises in smokers exclusion criteria: 1. adults with pulmonary disease. 2. acute infections 3. any other systemic disease. 4. chest deformity. 5. adults with any disability.

Keywords: deep breathing exercises, smokers, lung function