Kornimate/medical-research-clean huggingface dataset:
physiological changes induced through mep conditioning in people with sci

Conditions: Spinal Cord Injuries; Neurological Injury; Paralysis; Spasticity, Muscle

Summary: the study team is currently recruiting volunteers who are interested in participating in a brain-spinal cord-muscle response training study that aims to better understand the changes that take place in the nervous system as a result of this type of training. after spinal cord injury, brain-to-muscle connections are often interrupted. because these connections are important in movement control, when they are not working well, movements may be disturbed. researchers have found that people can learn to strengthen these connections through training. strengthening these connections may be able to improve movement control and recovery after injuries. research participants will be asked to stand, sit, and walk during the study sessions. electrodes are placed on the skin over leg muscles for monitoring muscle activity. for examining brain-to-muscle connections, the study team will use transcranial magnetic stimulation. the stimulation is applied over the head and will indirectly stimulate brain cells with little or no discomfort. participation in this study requires approximately three sessions per week for four months, followed by two to three sessions over another three months. each session lasts approximately 1 hour.


Eligibility criteria:
inclusion criteria: * neurologically stable (\>1 year post sci) * medical clearance to participate * ability to ambulate at least 10 m with or without an assistive device (except for parallel bars) * signs of weak ankle dorsiflexion at least unilaterally * expectation that current medication will be maintained without change for at least 3 months; stable use of anti-spasticity medication is accepted exclusion criteria: * motoneuron injury * known cardiac condition (e.g., history of myocardial infarction, congestive heart failure, pacemaker use) * medically unstable condition * cognitive impairment * history of epileptic seizures * metal implants in the cranium * implanted biomedical device in or above the ches (e.g., a cardiac pacemaker, cochlear implant) * no measurable mep elicited * unable to produce any voluntary ta emg activity * extensive use of functional electrical stimulation to the leg on a daily basis * pregnancy (due to changes in weight and posture and potential medical instability)

Keywords: corticospinal tract neuroplasticity
comparison of dynamic neuromuscular stabilization exercises and deep cervical muscle exercises on muscle fat infiltration in individuals with neck pain

Conditions: Non-specific Neck Pain

Summary: this clinical trial study aims to compare the effects of dns (dynamic neuromuscular stabilization) exercises and deep cervical muscle exercises on fat infiltration, disability, and posture in individuals with chronic non-specific neck pain. the clinical questions of this study are as follows: * can dns and deep cervical muscle exercises decrease muscle fat infiltration? * can dns and deep cervical muscle exercises improve neck disability? * can dns and deep cervical muscle exercises improve neck posture? researchers will compare dns and deep cervical muscle exercises to people with non-specific neck pain. dns exercises are hypothesized to significantly reduce fat infiltration and improve neck disability and neck posture compared to deep cervical muscle exercises. the participants will undergo an mri scan and clinical assessment, such as ndi (neck disability index) and posture checking, before being randomly divided into two groups. the first group will perform dns exercises, and the second group will engage in deep cervical muscle exercises. both sets of exercises will be performed for 16 weeks as part of a daily routine. after the 16-week exercises, the participants will undergo a follow-up mri, ndi, and posture checking.


Eligibility criteria:
inclusion criteria: * non-specific neck pain condition for three months or more * mild to moderate disability ( more than 10% of ndi) * mild to moderate pain level(2-8/10 of nrs) exclusion criteria: * a history of spine surgery or cervical injury * participated in a neck exercise program in the past three months * upper extremity problems * radiating pain, numbness, and weakness of the upper extremities * a detectable pathological spinal condition * metabolic disorders, diabetes, and hypertension obesity

Keywords: dynamic neuromuscular stabilization deep neck muscle exercise fatty infiltration medical resonance imaging non-specific neck pain
safety and efficacy study of radioembolization in combination with durvalumab in locally advanced and unresectable hcc

Conditions: Hepatocellular Carcinoma

Summary: safety and efficacy study of radioembolization with yttrium-90 microspheres in combination with durvalumab in locally advanced hepatocellular carcinoma

this is a single arm, open-label study to evaluate safety and efficacy of radioembolization with yttrium-90 microspheres in combination with durvalumab in locally advanced and unresectable hepatocellular carcinoma which to be implemented at a single site in korea. transarterial radioembolization (tare) with yttrium-90 microspheres will be employed in combination with an intravenous (iv) durvalumab until pd. tare will be performed before the first dose of durvalumab. exploratory biomarker testing will be done on tumor tissues prior to treatment and plasma samples prior to treatment and at the time of pd.

Eligibility criteria:
inclusion criteria: * diagnosed with unequivocal hcc confirmed histologically or diagnosed radiologically * locally advanced hcc * must have at least 1 untreated measurable disease * child-pugh score ≤7 points * adequate normal organ and marrow function. exclusion criteria: * eligible for potentially curative treatment (surgical resection, radio-frequency ablation or immediate liver transplantation) * prior treatment with an anti-pd-1, anti-pd-l1, anti-pd-l2, anti- cytotoxic t-lymphocyte-associated antigen-4 (anti-ctla-4) antibody * any other concurrent malignancy, except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, papillary thyroid cancer, early gastric cancer, or other cancer for which the patient has been disease-free for at least five years. * evidence of extrahepatic metastasi(e)s, except for regional lymph node(s) involvement * history of leptomeningeal carcinomatosis , history of active primary immunodeficiency * current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab. exclusion criteria specific to radioembolization: •the screening angiogram and technetium-99m macroaggregated albumin (99mtc-maa) scan are used to determine lobar liver volume from ct or mr images, to identify vascular shunting to the gi tract requiring use of angiographic occlusion techniques and to determine the lung shunt fraction. patients who are ineligible to radioembolization meeting the following criteria will not be included in the study. additional patients will be screened to replace those patients. * deposition of yttrium-90 microspheres to the gi tract that cannot be corrected by placement of the catheter distal to collateral vessels or the application of standard angiographic techniques, such as coil embolization to prevent deposition of yttrium-90 microspheres in the gi tract. * exposure of radiation to the lungs exceeds 30 gray (gy) for a single infusion or 50 gy cumulative for all infusions of yttrium-90 microspheres.

Keywords: hcc durvalumab
a comparison of the effectiveness of two types of myofunctional appliances

Conditions: Tooth Position Anomalies

Summary: a randomized clinical trial is set out to compare the effectiveness of two types of functional appliances in the correction of a class ii malocclusion. (class ii malocclusions are where upper front teeth bite significantly further forward in relation to lower front teeth).

it is a multicenter randomized clinical trial with two arms parallel group. the patients will be randomly divided into two groups, group one: myobrace appliance will be used while, and group two twin-block appliances will be used. cephalometric x-ray will be taken before starting the treatment (t1) and at the end of treatment (t2) at 9 months. the effectiveness of the two appliances will be assessed and measured comparing the difference in the cephalometric x-ray before and after treatment.

Eligibility criteria:
inclusion criteria: 1. growing children who need myofunctional appliance. 2. cl ii div. 1 malocclusion. 3. no previous orthodontic or orthopaedic treatments. exclusion criteria: 1. patients with systemic involvement. 2. congenital malformations such as cleft lip and palate. 3. facial deformities. 4. finger sucking habit will be excluded

Keywords: myofunctional appliance myobrace. twin-block cl ii div i malocclusion
the degree of forward head posture and hamstring muscles tightness

Conditions: Forward Head Posture

Summary: is the degree of forward head posture correlated with the degree of hamstring muscles tightness

i will measure the degree of forward head posture by photogrammetry method and classify the degree according to its severity measuring the hamstring muscles tightness and classify it too according to its severity and calf muscle tightness lumber flexibility and correlate the to the degree of forward the forward head posture and the degree

Eligibility criteria:
inclusion criteria: 1. adult participants 18-30 of age 2. craniovertebral angle \< 490 3. with or without neck pain * subjects with mechanical neck pain (in individual with chronic non-specific neck pain) * subjects are not engaged in any sports or athletic routine neck disability index \>5 points exclusion criteria: .prevalence of serious pathology (rheumatoid arthritis, ankylosing spondylitis, malignancy, infection, inflammatory disorders). vascular syndrome such as vertebrobasilar insufficiency cervical spine history of trauma, fracture, congenital anomalies, or surgical intervention . progressive neurological deficits . .history of lumbar and cervical herniated intervertebral disc with spinal stenosis history of neurological (guillain-barre, peripheral neuritis) or orthopedic disorders (osteoporosis, osteoarthritis) moderate or severe scoliosis history of lower extremity fracture and surgery with malunion leg length discrepancy bmi \ 29.9

Keywords: hamstring muscles tightness calf muscles tightness
evaluation of the efficacy of oral immunotherapy with raw apple in patients allergic to birch pollen and apple: prospective, multicenter, comparative phase iii study

Conditions: Allergies

Summary: apple-birch pollen-food allergy syndrome is particularly common in northern and central europe (70% of patients allergic to birch pollen), and classically induces an oral syndrome that impairs patients' quality of life. current treatment is based on food avoidance. however, evidence of the efficacy of this treatment is limited (small numbers, lack of validation with a control group, absence of double-blind evaluation of the primary endpoint in a challenge test against placebo). the aim of oral immunotherapy with raw apple is to improve the management of allergic patients by enabling them to acquire tolerance to raw apple and other rosacea.


Eligibility criteria:
inclusion criteria: * patient with allergic rhinitis to birch pollen. * patient with an oral syndrome within 15 minutes of consuming at least one of the first 3 doses of raw apple in the v0 or v1 raw apple oral challenge test. * evidence of sensitization to pr10 proteins in birch pollen and apple: positive prick tests to birch pollen and raw golden apple and/or positive bet v 1 and mal d 1 specific ige assays. * subject affiliated to a social health insurance scheme * subject able to understand the aims and risks of the research and to give dated and signed informed consent * for women of childbearing age: negative urine pregnancy test at inclusion visit exclusion criteria: * severe or uncontrolled asthma * severe obstructive syndrome * active neoplastic disease * active autoimmune disease * eosinophilic esophagitis or other active eosinophilic gastrointestinal pathologies * history of bariatric surgery * history of anaphylaxis to apples * allergy to cooked apples * contraindication to anti-histamines, corticoids, salbutamol, adrenaline * other contraindication to an oral challenge test * allergy to placebo ingredients * presence of oral syndrome during consumption of placebo in the first oral challenge test * allergenic immunotherapy to birch pollen in progress or completed less than 5 years ago * current treatment with anti-ige, anti-il4/13, anti-il5 or anti-tslp biotherapy. * impossibility of giving the subject informed information * subject under court protection * subject under guardianship or curatorship * pregnancy

Keywords: allergy oral immunotherapy
open label trial assessing safety and efficacy of burosumab (krn23), in a patient with ens and hypophosphatemic rickets

Conditions: Hypophosphatemia; Hypophosphatemic Rickets; Pain, Chronic

Summary: a 52 week, open label trial to assess the safety and efficacy of krn23, an investigational antibody to fgf23, in a single pediatric patient with epidermal nevus syndrome(ens) and associated hypophosphatemic rickets a 26 weeks extension to original study to monitor patient lab results for her safety.

1.1 primary objective the effect of krn23 treatment on normalizing age-adjusted serum phosphorous levels in a single pediatric patient with epidermal nevus syndrome associated hypophosphatemic rickets 1.2 secondary objectives 1. the pd profile of krn23 as assessed by changes from baseline over time 1,25(oh)2d, ipth, serum calcium, trp and tmp/gfr (the ratio of renal tubular maximum phosphate reabsorption rate to glomerular filtration rate) 2. changes in underlying skeletal disease/rickets as assessed by standard radiographs utilizing the radiographic global impression of change (rgi-c) rating scales 3. effects of krn23 on biochemical markers of bone turnover that reflect rickets severity, alkaline phosphatase (alp) 4. walking ability as assessed by 6-minute walk test (6mwt) 5. patient/parent-reported outcomes as assessed by promis and fps-r rating scales 1.3 exploratory objective 1. dual-energy x-ray absorptiometry (dxa) 1.4 safety objective assess the safety of krn23 administration in a single patient with ens-associated hypophosphatemic rickets, based on adverse events (aes), laboratory assessments, cardiac imaging and renal ultrasound.

Eligibility criteria:
inclusion criteria: 1. patient has confirmed ens by physician diagnosis 2. patient has confirmed fgf23 elevations in the context of low serum phosphorous \< 4.1 mg/dl 3. patient able to tolerate krn23 treatment 4. have a corrected serum calcium level \< 10.8mg/dl 5. have an egfr \>60 ml/min 6. must be willing in the opinion of the investigator, to comply with study procedures and schedule 7. provide written informed consent by a parent after the study has been explained and prior to any research related procedures begin exclusion criteria: 1. concomitant use of active vitamin d (i.e calcitriol) and/or exogenous phosphate supplementation. patient will be allowed otc vitamin d should levels drop below \<20 ng/ml 2. the use or enrollment in studies using other investigational therapies including other monoclonal antibodies 3. subject and their parent not willing or not able to give written informed consent 4. in the investigators opinion, the patient may not be able to meet all the requirements for study participation 5. patient has a history of hypersensitivity to krn23 excipients that in the opinion of the investigator, places the patient at an increased risk of adverse effects 6. patient has a condition that in the opinion of the investigator could present a concern for subject safety or data interpretation.
respiratory health of elite athletes

Conditions: Asthma; Cardiovascular Diseases; Metabolic Diseases

Summary: eleven national sports teams are located in the quebec metropolitan area. in these groups, many athletes are aiming for olympic medals in beijing 2008 and vancouver 2010 olympic games. a consultation of the coaches of these national teams revealed that although a large proportion of these athletes present various cardio-respiratory symptoms, they do not have a rapid access to a systematic medical evaluation and follow-up. furthermore, little is done in regard to prevention and optimization of treatment of pulmonary and cardiac conditions in the elite athlete's population of the quebec area. cardiorespiratory problems are therefore commonly found in high-level athletes. however, these pathologies are not well characterized in athletes and the associated symptoms often not well perceived. these problems can be serious and it is important to detect them before they appear1 while setting up a systematic medical follow-up. health professionals should monitor health of the young athletes and help to reduce the risks associated with high level exercise. the following project is an evaluation and follow-up program of high-level athletes, aiming at gathering key-information on long-term effects of high-level training on cardio-respiratory and metabolic parameters. our aims will be 1. to establish a long-term program of systematic evaluation and follow-up of cardiorespiratory health and performance of high elite athletes. 2. to evaluate the prevalence of respiratory, circulatory and metabolic problems among high-level athletes 3. to evaluate the effects of treatments on cardiorespiratory conditions and exercise performance in athletes who need asthma medication.


Eligibility criteria:
inclusion criteria: * athletes training more than 10 hours per week- exclusion criteria: * asthma or other pathologies that may interfere with the study * smokers * obese of with a bmi more than 29

Keywords: asthma environment type of sport cardiovascular disease athletes
genetic predictors of renal dysfunction following heart transplantation

Conditions: Heart Transplantation; Chronic Renal Insufficiency

Summary: kidney disease is a common problem after heart transplantation. it may be caused by anti-rejection medications such as cyclosporine or tacrolimus. however, the reason why some people develop kidney problems after a heart transplant, but other people do not, is not fully known. this study plans to learn more about the relationship between a person's genetic make-up (dna; deoxyribonucleic acid) and the risk of kidney problems after a heart transplant. the long-term goal of this research is to identify genetic variations that may help predict the development of kidney problems after heart transplantation.


Eligibility criteria:
inclusion criteria: * cardiac-only transplant * 18 years of age or older at the time of cardiac transplant * 1 year or more post-cardiac transplant * treatment with cyclosporine or tacrolimus following transplant exclusion criteria: * combined organ transplant * decisionally impaired * unable to read or speak english * unable or unwilling to provide written informed consent

Keywords: heart transplantation chronic renal insufficiency pharmacogenomics cyclosporine tacrolimus
long term results of randomized prospective comparison of onlay and sublay mesh repair techniques for incisional hernia

Conditions: Incisional Hernia

Summary: randomised prospective comparison of onlay and sublay mesh repair techniques in incisional hernia


Eligibility criteria:
inclusion criteria: * incisional hernia * acceptance of the trial exclusion criteria: * bmi\>40 * asa score of 4 * severe pulmonary or cardiac disease
heat therapy and peripheral artery disease

Conditions: Peripheral Arterial Disease; Cardiovascular Health; Vascular Function; Intermittent Claudication; Peripheral Vascular Diseases

Summary: the purpose of the study is to assess the efficacy of a novel 8 week heat therapy intervention in intermittent claudication compared to usual care controls. participants will be enrolled on a wait-list control randomised trial testing physiological, mechanistic, and health related outcome measures.

70 participants with pad will be randomised into one of two groups: either wait-list controls (usual care) or heat therapy intervention. the 8 week heat therapy intervention will consist of shoulder depth submersion in a hot tub at \~40°c for three times a week. time for heating will be graded with aim of \~60 minutes submersion time by the end of the intervention. after 8 weeks the wait-list control group will then enrol onto the heat intervention and heat therapy participants will go back to usual care. the primary outcome measure for the study is improvement in maximum walking distance, pain free walking, and time to onset claudication. this will be measured via a graded exercise test. secondary outcomes include quality of life as measured by generic and vascular specific questionnaires (sf-36,vascuqol and eq-5d-5l), vascular health measured using abpi, blood pressure, fmd, pwv, and markers of inflammation, oxidative stress, angiogenesis and vascular remodelling will be assessed from blood samples. all aforementioned outcome measures will be taken at baseline, 8 weeks, and 16 weeks. physical activity behaviour (measured with an accelerometer) will be monitored 7 days prior to the beginning of the study, 7 days prior heat intervention, and 7 days after heat intervention.

Eligibility criteria:
inclusion criteria: * • aged \> 18 years * abpi \< 0.9 at rest or a drop of 20mmhg after exercise testing * diagnosed with ic * able to walk unaided * english-speaking and able to follow instructions * no previous history of heat syncope * post-menopausal or not on hormone therapy * able to provide informed consent exclusion criteria: * • walking impairment for a reason other than pad * critical limb ischaemia/rest pain * asymptomatic pad * active cancer treatment * clinically diagnosed diabetes or those with peripheral neuropathy * recent / frequent heat exposure (e.g., sauna or hot tubs). * severe aortic stenosis, unstable angina, recent mi, stroke or tia

Keywords: heat therapy cardiovascular health endothelial function heat intervention