Kornimate/medical-research-clean huggingface dataset:
oral care study on burn patients

Conditions: Burn

Summary: there have been multiple articles done regarding oral hygiene on patients in burn and intensive care patients. all articles agree the need for good oral hygiene in these special needs patients. they also note that more research needs to be done on this subject, yet have no direction of how to proceed in this research. currently, no research has been done on the burn/intensive care patient to see if there is a difference form the non-hospitalized patient which oral hygiene protocol is based on.

background imforation and introduction there have been multiple articles done regarding oral hygiene on patients in burn and intensive care patients. all articles agree the need for good oral hygiene in these special needs patients. they also note that more research needs to be done on this subject, yet have no direction of how to proceed in this research. currently, no research has been done on the burn/intensive care patient to see if there is a difference form the non-hospitalized patient which oral hygiene protocol is based on. ojective the primary purpose of this prospective study is to determine if the burn/intensive care patient's oral condition is similar or different from the normal standard. patient selection criteria 1. patients age must be 19 and older. 2. patients must be on a ventilator in the burn or intensive care unit. 3. the control group will be 19 years or older and be randomly picked from from volunteer staff at saint elizabeth regional medical center. design this is a prospective study that will look at the similarities and difference of both groups. this will help us determine if there is a need to improve oral hygiene protocol given to burn/intensive care patients. each group will consist of 25 subjects

Eligibility criteria:
inclusion criteria:patient selection criteria 1. patients age must be 19 and older. 2. patients must be on a ventilator in the burn or intensive care unit. 3. the control group of healthy volunteers will be 19 years or older and be randomly picked from volunteer staff at saint elizabeth regional medical center. exclusion criteria: * unable to complete informed consent process

Keywords: thermal burn trauma
a study to evaluate the safety of rituximab retreatment in subjects with lupus nephritis previously enrolled in study u2970g

Conditions: Lupus Nephritis

Summary: this is a phase iii, multicenter, extension study to evaluate the safety of rituximab administered on a scheduled basis approximately every 6 months. all subjects who complete their week 52 visit in study u2970g will be eligible for this study, as long as the inclusion and exclusion criteria are met.


Eligibility criteria:
inclusion criteria: * ability and willingness to provide written informed consent and comply with the requirements of the study protocol * participation in study u2970g and completion of the week 52 visit in that study * for subjects of reproductive potential (males and females), use of a reliable means of contraception throughout their study participation exclusion criteria: * discontinuation or withdrawal from study u2970g or failure to complete the week 52 visit * any safety concern potentially attributable to rituximab that in the investigator's opinion may jeopardize subject safety * in the investigator's opinion, lack of any clinical improvement by week 52 in study u2970g and for whom the proposed therapy would represent risk without benefit * current thrombocytopenia or at high risk for developing clinically significant bleeding or organ dysfunction requiring therapies such as plasmapheresis or acute blood or platelet transfusions * lack of peripheral venous access * pregnancy or lactation * history of severe, allergic, or anaphylactic reactions to humanized or murine monoclonal antibodies * significant new or uncontrolled disease in any organ system not related to sle (e.g., poorly controlled chronic obstructive pulmonary disease or asthma, cardiovascular disease, accelerated hypertension, major depression) that in the investigator's opinion would preclude subject participation * known active infection of any kind (excluding fungal infection of nail beds), any major episode of infection requiring hospitalization, or treatment with iv antibiotics within 4 weeks of a study drug infusion or oral antibiotics within 2 weeks of a study drug infusion * history of cancer, including solid tumors, hematologic malignancies, and carcinoma in situ * major surgery within 4 weeks prior to screening * intolerance or contraindication to oral or iv corticosteroids * lipase \> 2 x the upper limit of normal (uln) * aspartate aminotransferase (ast) and alanine aminotransferase (alt) \> 2.5 x the uln * amylase levels \> 2 x the uln * absolute neutrophil counts \< 1.5 x 10\^3/ul * history of positive hepatitis b surface antigen or hepatitis c serology * hemoglobin \< 7 g/dl unless caused by autoimmune hemolytic anemia resulting from sle * platelet count \< 10,000/ul * receipt of a live vaccine within 28 days prior to treatment

Keywords: lupus u2970g
occurrence and influencing factors of cognitive impairment in elderly patients with schizophrenia and

Conditions: Schizophrenia Disorders; Cognitive Impairment; Acceptance and Commitment Therapy

Summary: act combined with stratified intervention improved cognitive function and quality of life in elderly schizophrenia patients by enhancing psychological flexibility and family support.

this study analyzes factors influencing cognitive impairment and evaluates the efficacy of a stratified intervention combining acceptance and commitment therapy (act) with these factors to improve cognitive function and quality of life. a total of 149 elderly patients with schizophrenia were enrolled, split into cognitive impairment (n = 86) and non-cognitive impairment (n = 63) groups. a combined case-control and randomized controlled trial design was employed. logistic regression was used to identify independent risk factors. cognitive impairment patients were randomly assigned to either the conventional treatment group (n = 39) or the act group (n = 39) for a 6-week intervention. evaluation instruments included the aaq-ii (psychological flexibility), gses (self-efficacy), faces ii-cv (family functioning), ssmi-c (internalized stigma), and sqls (quality of life).

Eligibility criteria:
inclusion criteria: * (1)meets the diagnostic criteria for schizophrenia as defined in the international classification of diseases, tenth revision (icd-10); * (2) age \> 60 years; * (3)possesses at least a primary school education, enabling independent completion of all questionnaires; * (4) has been taking antipsychotic medication continuously and regularly for at least one year during the enrollment period, with current symptoms and disease status stabilized in the maintenance phase; * (5)informed consent obtained from the patient or their family/guardian. exclusion criteria: * (1) coexisting organic mental disorders, affective disorders, or similar conditions; * (2) coexisting physical illnesses that may affect cognitive function, such as hepatic or renal dysfunction; * (3) alcohol dependence or dependence on psychoactive substances; * (4) receipt of electroconvulsive therapy within the past three months.
conscious2 study of the isolated forearm technique commands

Conditions: Anesthesia Awareness

Summary: conscious-2 is a multi-site study exploring the cognitive state of the isolated forearm test (ift) responder while under anesthetic.

500 participants between the ages of 18-40 who will be undergoing surgery requiring general anesthetic will be recruited for this study. this study will use the isolated forearm test (ift) to identify patients at risk of anesthesia awareness. in the ift, induction of anesthesia is followed by inflation of a cuff on the dominant arm before neuromuscular blockade (paralysis) is induced. the cuff prevents paralysis of the hand allowing the patient to communicate to an observer through predefined hand movements, typically following a command like: "mrs. jones, if you can hear me, squeeze my hand". participants will thus be asked to follow a series of commands intraoperatively to assess awareness. routinely recorded clinical data will be collected to frame the observations about ift responsiveness, and non-invasive eeg data will also be collected to provide information about the "brain state" of the patients. patient reported confusion and objectively measured confusion using the nurse based delirium screening tool (nudesc) will be collected post operatively. finally, participants will be contacted 24 hours and 7 days following their operation to complete an anesthesia satisfaction questionnaire.

Eligibility criteria:
inclusion criteria: 1. age 18-40 years 2. english (or local language) competent 3. informed consent obtained 4. patients clinically requiring general anesthesia and intubation 5. able to safely follow the ift commands when awake and prior to their operation, per discretion of the pi. exclusion criteria: 1. age \ 40 years old 2. unable or unwilling to sign consent 3. unable to undergo postoperative questions 4. contraindication to ift test such as unable to have tourniquet on arm for the ift (e.g. lymphedema or operative site), rapid sequence inductions and requiring paralysis for laryngoscopy and intubation, per discretion of the pi.

Keywords: consciousness electroencephalography anesthesia
cone beam ct (cbct) arthrogram of the ankle in assessement of osteochondral or cartilage lesions

Conditions: Cartilage Lesion; Osteochondral Lesion

Summary: this study aims to compare weight-bearing cone beam ct arthrogram and conventional ct arthrogram in assessement of patients with ankle osteo-chondral or cartilage lesions.

weight-bearing cone beam ct (cbct) arthrogram, a technique with less radiation dose than conventional ct, is hypothesized non-inferior to conventional ct arthrogram to diagnose osteo-chondral (ocl) or cartilage lesions of the ankle.

Eligibility criteria:
inclusion criteria: * patients aged ≥ 18 years; * patients require ct arthrogram of the ankle; * affiliated to a social security schema; * informed consent signed by patients. exclusion criteria: * pregnant women; * impossibility of injection of intra-articular contrast product; * hypersensitivity reactions to iodinated contrast agent; * patient refusal; * patient under french ame scheme; * patient under guardianship by tutor or curator.

Keywords: cartilage lesion osteochondral lesion osteochondral defect cone beam arthrogram cbct arthrogram ct arthrogram weight bearing cbct ankle
hypertension and cardiovascular risk associated with obstructive sleep apnea in adult in guadeloupe (french west indies)

Conditions: Hypertension Arterial

Summary: the mapa is the reference method to estimate the pa during the sahos. the mapa can be recommended over 48 hours: indeed, the pa falls at the beginning of every apnea then increases gradually up to a pressif peak arising at the time of the ventilatoire resumption. these variations arise under the influence of 4 stimulus: the désaturation in o2, the rise of the paco2, the increase of the respiratory effort and the microawakening of the end of apnea who are at the origin of a sympathetic stimulation. consequently a better diagnostic approach of the hta (confirmation of a resistant hta, an identification of the masked hta and the patients " not dipper " by the mapa), the identification of the sahos, and a better coverage) of the associated cardiovascular risk factors are essential and establish a stake in public health. to investigator's knowledge, no datum or study on the association hta-sahos and its consequences was until then realized in the french overseas departments.

in guadeloupe, data on the relationships between arterial hypertension and obstructive sleep apnea are unavailable. the aim of this study was: to assess the frequency of hypertension and non-dipper pattern evaluated by 48-hour ambulatory blood pressure monitoring in an adult population identified obstructive sleep apnea/non-obstructive sleep apnea during overnight polygraphy ; to determine the cardio-metabolic factors associated with obstructive sleep apnea.

Eligibility criteria:
inclusion criteria: * patient suspected of sahos; * patient or third-party responsible for receiving information on the study and who signed informed consent ; * patient age over 18 years; patient living in guadeloupe. exclusion criteria: * patient non-affiliated to the social security scheme ; * patient with obstructive bronchopneumopathy, neuro-muscular pathology, * central and mixed sas, cardiac arrhythmia, * systemic and chronic inflammatory syndrome ; - * pregnant and lactating patient ; * patient in emergency.

Keywords: sleep apnea arterial hypertension cardiovascular risk
families left behind

Conditions: Grief; Grief Disorder, Prolonged; Overdose Accidental; Substance Use Disorders

Summary: the united states is facing unprecedented rates of drug overdose deaths, profoundly impacting millions of families who are left to navigate their grief. those bereaved by overdose experience a unique form of grief characterized by feelings of guilt, shame, and blame, which can worsen their suffering and deter them from seeking help. individuals coping with overdose loss often endure more severe health consequences compared to those grieving non-drug related deaths, including prolonged grief disorder, substance use disorders, ptsd, depression, and suicidal thoughts. moreover, bereaved individuals, particularly those with a history of substance use, may engage in risky behaviors as a means of coping, further exacerbating the risk of overdose and mortality within this vulnerable population. peer grief support interventions have emerged as a promising approach to assist those experiencing such losses. to combat these outcomes, we are collaborating with peer community support partners (pscp) in a novel practice-research partnership to implement the river peer grief support model. though river has shown success in community settings, it has yet to be rigorously evaluated. in a three-aim approach, this study aims to assess the effectiveness of the river model while also enhancing and engaging grievers with support resources via medical examiner offices (meos), which routinely contact families during death investigations. this research represents a pivotal advancement in addressing the needs of the overlooked bereaved community, aligning with the nih's helping to end addiction long-term (heal) initiative to develop effective strategies against the opioid crisis. together, community engagement and rigorous research efforts aim to enhance support for those affected by the tragedy of drug overdose.


Eligibility criteria:
inclusion criteria: * people who lost a loved one to an unintentional drug overdose death within the past year * age 18 and older * fluently understand english or spanish * have the capacity to give consent (e.g., excluding those with severe cognitive impairment, those in active psychosis, and those with developmental disabilities). exclusion criteria: * people who need hospitalization for psychiatric symptoms or substance use disorders. (note, people who use drugs but who do not require hospitalization will be included.) * people have active suicidal ideation * people who lost someone to a drug overdose death more than one year ago * people who lost someone to a drug overdose death that was suicidal in nature or of undetermined intent

Keywords: overdose grief bereavement prolonged grief disorder
can exercise training reduce the frequency and severity of hot flushes associated with breast cancer treatment?

Conditions: Breast Cancer

Summary: in brief, this study sets out to understand if exercise training can reduce the frequency and severity of hot flushes associated with breast cancer treatment.

in detail, the aim of this research project is to investigate whether improving temperature control mechanisms including vascular function, with exercise training is beneficial in alleviating hot flushes in breast cancer patients and their associated quality of life symptoms. participants will be recruited at least 3-months post breast cancer treatment (surgery, radio-therapy, chemotherapy). this time point has been chosen for this study to allow patients to fully engage in the exercise intervention following treatment. all participants will be asked to attend the laboratory at liverpool john moores university on 4 separate occasions; 2 visits pre- and 2 visits following the exercise intervention for data collection including measures of vascular health, physical activity, sedentary behaviour, and fitness. the investigators will also gain information on food intake and incidence of hot flushes across a 7-day period pre- and post the intervention.

Eligibility criteria:
inclusion criteria: * able to provide written informed consent * pre-menopausal, peri-menopausal or post-menopausal * \>4 hot flushes per day * female * treated with tamoxifen or aromatase inhibitor exclusion criteria: * uncontrolled or severe hypertension (blood pressure \> 160/100 mm hg) * any previous injury preventing exercise * type 1 or 2 diabetes * anti-depressants * currently undergoing chemotherapy or radiotherapy * current smoker * cannot readily read and understand english

Keywords: vascular function vascular structure thermoregulation hot flushes cerebral blood flow exercise training
kinematic and kinetic effects of orthotic devices for subjects with stage ii posterior tibial tendon dysfunction

Conditions: Posterior Tibial Tendon Dysfunction

Summary: the lack of high quality evidence to guide conservative care for patients with posterior tibial tendon dysfunction (pttd) has led to controversy over clinical care. numerous orthotic devices are available to avoid a costly and debilitating surgery but no consensus on which to use has been made. the current study aims to link biomechanical testing of selected devices to clinical outcomes in subjects with pttd after wearing a device for 12 weeks.

orthotic devices serve as essential elements of conservative care programs for posterior tibial tendon dysfunction (pttd). data on currently used devices remain limited. current device designs are restrictive and focus on correction of flatfoot kinematics in subjects with stage ii pttd. restrictive designs that limit ankle motion may lead to weakness and altered gait dynamics. it remains unclear if less restrictive device designs would be more optimal for subjects with stage ii pttd. the aims of the current proposal are to examine the in-vivo biomechanics of different device designs and to use outcomes to identify the device and design optimal for subjects with stage ii pttd. research design: this study will use a laboratory based repeated measures design to explore the function of four different orthotic devices in a sample of 60 subjects with stage ii pttd at baseline. then each subject will be followed prospectively for 12 weeks while wearing one of the orthotic devices. clinical outcomes including strength, tendon morphology, and self-reported outcomes will be measured at 12 weeks. baseline foot kinematics will be collected using a three segment foot model (first metatarsal, calcaneus, tibia) while data on ankle kinetics will be derived from the kinematic data and the ground reaction forces. impact: there are currently no head-to-head comparisons available among the various devices used in the conservative management of stage ii pttd. the proposed study will provide the necessary controlled data to determine the kinematic and kinetic effects of selected devices and the specific components needed to optimize device design. outcomes will be used to determine which designs are successful to use clinically.

Eligibility criteria:
inclusion criteria: * inclusion criteria stage ii pttd * swelling * pain with palpation along the tendon * rearfoot eversion * pain single leg heel raise * flexible flat foot deformity * able to walk 15 m * \> 40 years of age exclusion criteria: * unable to walk 15 m * symmes-weinstein monofilament test 5.06 mm * inflammatory arthropathies (e.g. rheumatoid arthritis, psoriasis) * co-morbid foot conditions (e.g. hallux rigidis, plantar fasciitis) * inability to assume a stn posture

Keywords: biomechanics outcomes foot orthotic device
comparing rater reliability of familiar practitioners to blinded coders

Conditions: Child Development; Premature Birth

Summary: the purpose of this study is to determine how coders who have seen multiple time points of the same dyad, and are therefore familiar with the case, rate emotional connection using the wecs compared to coders who are blinded to the case's previous time points. the investigator hypothesizes that the wecs will show external validity: that all coders will have high reliability on their wecs scores, despite exposure to the dyads' past videos by the clinical coders.

the purpose of this study is to determine the external validity of a scale for emotional connection between children and their parents through a retrospective longitudinal study. the welch emotional connection scale (wecs) is a screen that allows healthcare providers to rate the emotional connection of a mother-child relationship in just a few minutes of observed interaction, and shows preliminary predictive properties when performed in the first year of the child's life. administration of the wecs involves watching interactions of a child sitting face-to-face on a parent's lap, and scores the interaction on sliding scales in 4 domains. during the wecs development, the nurture science program of columbia university medical center created and coded hours of parent-child interaction videos. this video data set will be used to determine how clinical wecs scores, where raters are familiar with mother-child dyads over time, compare to research wecs scores, where rate-rs are blinded to each case. the wecs scores of clinical coders, who are exposed to the same case at different time points, will be compared to blinded coders who see cases at just one time point. to simulate implementation of the wecs in a clinical setting, two primary care nurse practitioner (pnp) students who are trained in rating emotional connection will view videos to rate the emotional connection of mother-child dyads collected at different time points. to recreate wecs used in a research setting, blinded coders trained in rating emotional connection will rate the emotional connection of the same video data set. each blinded coder will only view a dyad once, to not be influenced by previous time points of the same subject. the inter-rater reliability of the blinded and clinical coders will be determined. the comparison of inter-rater reliability scores between clinical and blinded coders is the main outcome of this study.

Eligibility criteria:
inclusion criteria: * children and their parents who participated in previously conducted studies (aaad0389) exclusion criteria: * children and their parents who had not participated in previously conducted studies (aaad0389)

Keywords: martha g. welch emotional connection child development premature birth
adipoa - clinical study

Conditions: Osteoarthritis

Summary: primary: to study the safety of a single injection of autologous adipose derived mesenchymal stromal cells (ascs) on patients with moderate or severe osteoarthritis of the knee (oa). secondary: to study the efficacy of a single injection of autologous adipose derived mesenchymal stromal cells on patients with moderate or severe osteoarthritis of the knee (oa).


Eligibility criteria:
inclusion criteria: * oa diagnosis should fulfil the criteria of the american college of rheumatology (acr) with moderate or severe medial and/ or external femorotibial knee osteoarthritis (oa) (stage 3 or 4) and indication total knee arthroplasty. exclusion criteria: * any disease or medication affecting the bone or cartilage metabolism, including corticoids.