Kornimate/medical-research-clean huggingface dataset:
tumor rna transfected dendritic cell vaccines

Conditions: Prostate Cancer

Summary: the purpose of this study is to use dendritic cells transfected with amplified rna from autologous tumor cells to develop a vaccine strategy for the treatment of prostate cancer in patients with disseminated disease.

the specific aims are: 1) to evaluate, in a phase i clinical trial, the safety of vaccinating patients with dendritic cells transfected with rna from autologous cancer cells; 2) to analyze the t cell responses induced by the treatment; and 3) to improve the efficacy of the treatment by developing methods to increase the induction of cd4+t cell responses.

Eligibility criteria:
inclusion criteria: * patients with a histologically confirmed diagnosis of metastatic prostate cancer stages d1 - d3 are eligible for this study. * they must not have a history of autoimmune disease, serious intercurrent chronic or acute illness, pulmonary disease, active hepatitis, serologic evidence for hiv, or be receiving corticosteroid or immunosuppressive therapy. exclusion criteria: * patients will be excluded from the study if they have received chemotherapy or other forms of immunotherapy in the 6 weeks prior to study entry.

Keywords: prostatic neoplasms neoplasm metastasis immunotherapy active dendritic cells
exercise effect on aerobic capacity and qol in heart failure

Conditions: Heart Failure, Congestive

Summary: chronic heart failure (hf) is a syndrome of impaired ventricular function resulting in clinical symptoms of fatigue, dyspnea, and decreased exercise capacity. these symptoms lead to a cyclical pattern of an increasing sedentary lifestyle with accompanying deconditioning and deterioration of muscle function. until recently, the prescription for individuals with hf was rest and minimization of physical exertion.

background: chronic heart failure (hf) is a syndrome of impaired ventricular function resulting in clinical symptoms of fatigue, dyspnea, and decreased exercise capacity. these symptoms lead to a cyclical pattern of an increasing sedentary lifestyle with accompanying deconditioning and deterioration of muscle function. until recently, the prescription for individuals with hf was rest and minimization of physical exertion. objectives: the primary objectives of this randomized clinical trial were to determine whether subjects, with moderate to severe chronic hf, who completed a 12-week individualized program of cardiopulmonary training (exercise group) would have significantly greater (i) quality of life, measured by the rand short form-36, and (ii) aerobic fitness, measured by oxygen uptake during symptom limited maximal metabolic treadmill testing, than subjects who met weekly with an investigator and received vital sign measurements (non-exercise group). methods: a randomized controlled clinical trial was utilized. individuals who met the inclusion criteria were randomly assigned to either an exercise or control group. individuals in the exercise group received 36 weeks of exercise training (primary outcome variables were measured at 12 weeks). participants in the control group received weekly visits with a nurse for 12 weeks. status: ongoing data analysis for publication. final report submitted.

Eligibility criteria:
inclusion criteria: left ventricular ejection fraction less than or equal to 40%. stable heart failure. exclusion criteria:
pilates to treat neck pain

Conditions: Mechanical Neck Pain

Summary: the neck pain comes from disturbances related to the cervical spine, of multifactorial origin and is considered a frequent problem of disability. pilates is a physical conditioning method that has been widely used to improve posture and develop body awareness. the aim of this study is to assess the impact of the pilates method in the control of pain, function and quality of life in patients with chronic mechanical neck pain. methods: 64 patients with chronic mechanical neck pain will be selected and randomized into two groups: intervention and control. both groups will be assessed for pain, function, quality of life and medication intake. the intervention group will hold pilates sessions for three months, with two sessions per week. the control group will continue with the usual drug treatment. both groups will be instructed to use 750mg acetaminophen every 6 hours if there is pain, but consumption of the drug will be controlled. although the symptoms of neck pain are common in the population, no study has investigated the effects of the pilates method as a possible treatment for neck pain. the hypothesis is that the pilates method can offer benefits to these patients.


Eligibility criteria:
inclusion criteria: * people with diagnosis of chronic mechanical neck pain and symptoms of pain in the lower region of spine, between the occipital and the first thoracic vertebra, for more than three months. * pain between 3 and 8 on the numerical pain scale * age between 18 and 65 * both genders * agree to take part in the study and sign the terms of agreement exclusion criteria: * fibromyalgia * previous traumatic injuries in the spine * infections and inflammation in the spine cervical pain radiating to upper limbs * the practice of physical activity started or altered in the last 3 months * visual deficiency not corrected by glasses, disturbance in the central nervous system, hearing deficiency making the use of the method impossible.

Keywords: mechanical neck pain pain function quality of life pilates
her2-directed biosimilar in breast cancer: real world epro

Conditions: HER2-positive Breast Cancer; Biosimilar; Patient Reported Outcome

Summary: this project will engage anti-her2 directed trastuzumab biosimilar with a novel quality of epro and enable comparison of reliable reference real world patient data, thereby creating a basis for analytic research in order to promote the quality and efficiency of treatment

comprehensive data on patient history and follow-up modalities, aes and outcome will be collected as epro to provide high-quality reports and quantitatively abundant data provided by patients. in particular, prospectively collected data shall be compared to previously collected epro from women treated for her2-positive bc in a variety of indications and settings . since a large number of data entries for wellbeing and symptom reporting (according to ctcae) is available from these patients, the investigators will refer to this as a historic registry data warehouse. accordingly, the epro from these patients treated for her2 positive bc are available for planned comparative analysis and shall be applied to indicate differences in anti-her2 directed medication between ogivri and herceptin.

Eligibility criteria:
inclusion criteria: * female patients * patients ≥ 18 years * patients with her2-positive breast cancer (ihc-fish/sish) * undergoing anti-her2 treatment during the observational period containing ogivritm (trastuzumab) +/- pertuzumab +/- chemotherapy * personal smartphone with ios or android system. the operating system must be updated to one of the two newest main versions exclusion criteria: * patients, whose compliance to the studies' protocol, e.g. due to mental health problems, physical problems, or the private life situation, can be justifiably doubted * patients with insufficient knowledge about the use of a smartphone

Keywords: epro her2 breast cancer biosimilar patient reported outcome app
correlation between serum albumin level and severity of hepatic encephalopathy in patients with chronic liver disease in sohag university hospital

Conditions: Hepatic Encephalopathy

Summary: assess the correlation between serum albumin levels and the severity of hepatic encephalopathy in patients with chronic liver disease. assess the impact of albumin level on clinical course and outcomes of he.

sample size calculation will be performed based on anticipated incidence rates of he and variability in serum albumin levels, aiming for a study population of 100-150 patients to achieve adequate statistical power. - all patients included in the study will be subjected to : glasgow coma scale (gcs) score. clinical assessment: baseline evaluation of patients to confirm chronic liver disease diagnosis and determine clinical characteristics. history of prior episodes of he, presence of ascites, variceal bleeding, and other complications of chronic liver disease . age, gender, etiology of cirrhosis (e.g., viral hepatitis, alcohol), comorbid conditions (e.g., diabetes, hypertension) * laboratory investigation : serum albumin level ast alt total bilirubin and direct cbc serum creatinine proth time and concetntration

Eligibility criteria:
inclusion criteria: * patients aged \>18 years. * confirmed chronic liver disease (by imaging , * liver function tests , and clinical history). * diagnosed with hepatic encephalopathy based on clinical criteria. * patients able to provide informed consent. exclusion criteria: * patients age less than 18 years old * acute liver failure. * chronic renal failure on dialysis. * pregnant women. * patients with active malignancy.
pediatric spinal muscular atrophy (sma) china registry

Conditions: Muscular Atrophy, Spinal

Summary: the primary objective of the study is to describe the natural history and utilization of disease modifying therapy (dmt) treatments among pediatric chinese participants with spinal muscular atrophy linked to chromosome 5q (5q-sma). the study will examine sma natural history and dmt outcomes in a real-world setting both prospectively and retrospectively.


Eligibility criteria:
key inclusion criteria: * ability of the participant and/or his/her legally authorized representative (e.g., parent or legal guardian), as appropriate and applicable, to understand the purpose and risks of the study, to provide informed consent, and to authorize the use of confidential health information in accordance with national and local privacy regulations. * genetically confirmed 5q-sma. * age \< 18 years at enrollment. key exclusion criteria: * unable or unwilling to provide informed consent. * other types of sma (non 5q-sma). note: other protocol defined inclusion/ exclusion criteria may apply.
substrate oxidation in girls

Conditions: Overweight Adolescents

Summary: this study will examine race differences in total energy expenditure and respiratory quotient (rq) during and after exercise, compared to a sedentary control condition, in adolescent girls who are classified as overweight. in addition, subjective appetite and objective energy intake will be measured throughout the assessment periods.

aim 1: measure 24-hour energy expenditure and its components (resting, activity, and sleep energy expenditure) and compare differences between african-american and white girls. hypothesis: total, resting, and sleep energy expenditure will be lower in african-american relative to white girls. activity energy expenditure will be equivalent per the study design. aim 2: measure and compare substrate oxidation and associations with appetite (i.e., hunger, desire to eat) and energy intake between african-american and white girls. hypothesis: african-american girls will have a higher rq at rest, during exercise, and following exercise, and rq will be positively associated with subjective appetite ratings and energy intake.

Eligibility criteria:
inclusion criteria: * female * age 13-17 years, inclusive * achieved menarche based on parent- and/or self-report * overweight based on bmi percentile for age and sex (≥ 85th and \< 95th) * self-identification as non-hispanic white or african-american * willing to maintain current physical activity, sleep schedule, and dietary habits during the study * willing to comply with study procedures exclusion criteria: * contraindications to exercise testing as defined by the american college of sports medicine (i.e., medical history of cardiovascular, pulmonary, or physical conditions that affect the ability to exercise) * food allergies * dietary restrictions * unwilling to consume study foods * history of polycystic ovary syndrome (pcos) * current amenorrhea or other menstrual cycle irregularities * pregnant or currently breastfeeding * current anemia * use of medications affecting metabolism or sleep * inability to properly or safely complete the study procedures per the investigators' discretion

Keywords: energy expenditure substrate oxidation appetite exercise energy intake
cervical manual therapy and vagus nerve stimulation in patients with nonspecific neck pain

Conditions: Pain Syndrome

Summary: people with chronic neck pain are becoming more and more common in society every day.

in chronic neck pain investigations, it is generally reported that all people experience neck pain once in my life and more than half of the developed societies experience this problem. it has been stated that 48% of these continue as chronic neck pain, which significantly affects the quality of life due to the postponement of treatment due to its cost.

Eligibility criteria:
inclusion criteria for volunteers and/or study participants; * presence of neck pain for at least three months * non-specific neck pain * to have signed the voluntary consent form exclusion criteria for volunteers and/or participants; * having undergone surgery for the cervical region * rehabilitation of the neck area at least three months prior to treatment * traumatic medulla spinalis injury * neurological deficit * rheumatological disease * structural spinal disorders
efficacy of ginger muco-bioadhesive gel in management of oral lichen planus with immunohistochemical analysis

Conditions: Oral Lichen Planus

Summary: 1. compare the clinical efficacy of topical ginger extract versus triamcinolone acetonide 0.1% for symptomatic oral lichen planus (primary objective). 2. investigate using immunohistochemical analysis the effect of the two different treatment modalities on fasl expression in oral lichen planus lesions (secondary objective).


Eligibility criteria:
inclusion criteria: * males or females, aged from 40 to 60 years. * clinically proven painful bullous/erosive (score 4) or atrophic (score 3) forms of olp confirmed by the presence of red or erythromatous changes, or shallow ulcerations with fine lacy lines at the periphery of the lesion accentuated by stretching and not eliminated by rubbing (wickham's striae) (lozada-nur and miranda, 1997) * histopathologically, proven bullous/erosive (score 4) or atrophic (score 3) forms of olp confirmed by the presence of accepted histopathological criteria for lichen planus; basal cell liquefaction, band like lymphocytic infiltrate at the epithelial-stromal junction with degeneration of basal cell region (ellis, 1967; van der meij and van der waal, 2003). exclusion criteria: * history of drug induced lichenoid lesions. * presence of systemic conditions as; serious active or recurrent infections, malignancy, diabetes mellitus, hypertension, or significant heart, liver, or renal diseases. assessed using medical questionnaire guided by cornell medical index (pendleton et al., 2004). * smoking. * known hypersensitivity or severe adverse effects to the treatment drugs or to any ingredient of their preparation as mentioned in medical history. * pregnancy or breast-feeding. * history of previous treatments potentially effective on olp such as antimalarial agents, retinoids, corticosteroids or immunosuppressive drugs from less than 2 weeks for topical medications, and 4 weeks for systemic medications prior to starting the study (swift et al., 2005). * patients suffering from lichen planus skin lesions. * loss of pliability or flexibility in the tissues involved by the oral lesions of lichen planus. * histological signs of epithelial dysplasia or lichenoid lesions within the biopsied. * refusing to participate in the study. * vulnerable groups (handicapped, orphans and prisoners).
internet supported group cognitive behavior therapy (cbt) for hoarding disorder (hd)

Conditions: Hoarding Disorder

Summary: the primary aim is to develop, and test the feasibility and efficacy of, a manual based, cognitive behaviour therapy (cbt) treatment for hoarding disorder (hd) delivered in a group format combined with an internet support system. the investigators' secondary aim is to investigate the neurocognitive profile of the participants before and after treatment in order to explore if the treatment might have an impact on neurocognitive functioning and if certain neurocognitive profiles predict outcome. for the primary aim, the investigators hypothesize that the treatment will be acceptable to participants and decrease symptoms of hoarding. regarding the secondary aim, the investigators hypothesize that deficiencies in executive functioning, as measured with a neurocognitive battery, will reduce upon completion of treatment and that baseline executive function will be associated with treatment outcome.


Eligibility criteria:
* inclusion criteria: * outpatients * male or female * ≥ 18 years of age * currently living in stockholm county * primary diagnosis of hoarding disorder according to dsm-5 * signed informed consent * regular access to a computer with internet and ability to use internet * access to a mobile phone * able to participate in group sessions * exclusion criteria: * current substance dependence or misuse * life time bipolar disorder or psychosis * severe self-rated depressive symptoms (score ≥ 35 on madrs-s) * suicidal ideation (score \> 4 on item 9 in madrs-s) * psychotropic medication changes within two months prior to the treatment * other current psychological treatment that could affect hoarding symptoms * has received more than 10 cbt sessions for hoarding disorder
the effect of aromatherapy applied after cesarean section on pain intensity and comfort level

Conditions: Cesarean Section Complications

Summary: today, many complementary therapies such as acupuncture, reflexology, homeopathy, hypnotherapy, music and aromatherapy are tried in addition to medical methods to reduce pain and anxiety. aromatherapy is a therapy method in which essential oils are used to protect and improve physical and psychological health. oils can be applied directly to a single person or indirectly to people in a room by inhalation . in direct application without steam, essential oils can be applied by inhalation by dripping onto a cotton ball . it is stated that lavender aromatherapy, one of the most commonly used aromatherapies, has analgesic, antiseptic, sedative, antispasmodic and healing properties ylang ylang aromatherapy is stated analgesic, anti-inflammatory, antimicrobial, antiemetic,anti-tarral, carminative, sedative, antiseptic, spasmolytic properties. in the studies conducted, anxiety, labor pain, labor duration, and psychological effects of aromatherapy were examined, but no study was found in which lavender and chamomile essential oils were used and the effects of pain and comfort level were examined. the aim of this study is to determine the effect of lavender and ylang ylang essential oils in relieving pain and increasing comfort after cesarean section.


Eligibility criteria:
inclusion criteria: * 18-49 years old, * women who have had a cesarean section exclusion criteria: * epilepsy, * migraine, * chronic headache, * asthma, * women who are allergic to fragrance sensitivities to aromatic oils

Keywords: aromatherapy pain ceserean
sacral erector spinae block for pilonidal sinus surgery

Conditions: Post Operative Pain

Summary: the incidence of pilonidal sinus disease (pd) is estimated to be around 26/100,000 individuals mostly men.pd can cause the development of abscess or a draining sinus tract and that may lead to a loss of productive power and long-term morbidity.different surgical technique approaches were proposed for treatment with different rates of success.

sacral erector spinae plane block was first described by tulgar et al. to provide sensory blockade in the parasacral region in two cases who had pilonidal sinus surgeries. since then, the block was used for multiple surgeries like anorecatal, hip surgery and parasacral reconstructive surgeries.after obtaining the ethical committee approval from menoufia university. patients scheduled for pilonidal sinus surgery will be randomly allocated into one of two groups patients will be randomized to a study group using a computer-generated random number table, and the allocation concealment will be performed using a sealed envelope technique.the sealed opaque envelopes will be kept locked in dedicated research safe and will be accessed by a research coordinator only when a patient consented for the study. the anesthetist will perform the intervention with the doses and concentration of drugs as per the protocol. the patients and the follow up researcher will be blinded to the type of intervention used. the patient follow-up time will be scheduled intraoperatively pacu, 1 hour and 24hours postoperatively. the anesthetist who did the intervention will have no access to the reported documents or contact with the patient postoperatively. for induction of anesthesia all patients will receive medication as per the facility protocol where propofol 1-2mg/kg, fentanyl 2μg/kg (actual bw), rocuronium 0.5 mg/kg will be used for induction and an endotracheal tube intubation will be inserted to secure the airway. after intubation and confirmation of endotracheal tube placement by auscultation and capnography, the patient will be turned into prone position. maintenance of anesthesia will be maintained by sevoflurane 1-1.2 mac and rocuronium 0.1mg/kg guided by the tof. all patients will receive multimodal analgesia in the form of paracetamol 1gm and parecoxib 40 mg (pizer manufacturing belgium). after exclusion of other causes of tachycardia and hypertension morphine 2mg increments will be administrated to keep the heart rate or blood pressure within 20 percent of the patient's baseline parameters.

Eligibility criteria:
inclusion criteria: * age \>18 years old * asa physical status 1-3 exclusion criteria: 1. asa \>3 2. opioid use within the previous 3 months 3. deranged coagulation parameters 4. patient refusal 5. allergy to local anesthetic medication. 6. preoperative neurological deficits