Kornimate/medical-research-clean huggingface dataset:
a clinical study of hyperthyroidism in children

Conditions: Hyperthyroidism

Summary: this study intends to conduct a retrospective and prospective study on children with hyperthyroidism, and it is a non-intervention study to collect information on diagnosis and treatment and long-term follow-up of children with hyperthyroidism. to investigate the clinical characteristics, treatment effect, side effects and remission of hyperthyroidism in children, to analyze the predictive factors for the effect of antithyroid drug treatment, remission and recurrence after drug withdrawal, and to explore the risk factors related to the occurrence of antithyroid drug-related adverse reactions.


Eligibility criteria:
inclusion criteria: 1. age ≤14 years old 2. initial diagnosis of hyperthyroidism exclusion criteria: 1. hyperthyroidism had been treated with medication in other hospitals, 2. history of autoimmune hepatitis, viral hepatitis, hematological diseases, bone marrow or liver transplantation, 3. patients with incomplete clinical data
novel medication as a potential smoking cessation aid

Conditions: Tobacco Use Disorder

Summary: the purpose of this study is to provide preliminary information assessing if levomilnacipran may be effective at increasing smoking cessation rates.


Eligibility criteria:
inclusion criteria: * be between 25 years old and 55 years old * smoke a minimum number of cigarettes per day * indicate motivation to quit smoking exclusion criteria: * current or history of medical or psychiatric conditions that could interfere with measures being studied or that could be affected by the study medication * use of medication that could interfere with measures to be studied or that could be expected to interact with levomilnacipran * are pregnant or breast feeding the investigators will evaluate if there are other reasons why someone may not be eligible to participate
transbrachial access for interventions in patients with peripheral arterial occlusive disease

Conditions: Complication of Treatment

Summary: the aim of the present study is an evaluation, whether an immobilization of the upper extremity by means of a positioning splint can help to reduce the incidence of local complications after transbrachial puncture for peripheral arterial interventions, or not.

increasing numbers of peripheral arterial interventions are performed via transbrachial access leading to a higher number of local complications at the puncture site. patients are demonstrating complications, such as hematoma, false aneurysm, secondary hemorrhage and arterial stenosis or occlusion. due to not standardized post-interventional procedure regarding to immobilization a higher risk for local puncture site complication can occur. usually, a compression bandage its applied to the brachial puncture site. within this randomized study, patients randomized to the study group will receive an additional splint for 24 hours to ensure an immobilization of the affected arm. following the removal of the compression dressing, and the splint in the study group, a duplex ultrasound its performed in order to detect local alterations and pathologies of the brachial artery. this examination is repeated for each patient in the course of an outpatient control six weeks post-interventionally. pathologies are documented and treated if necessary.

Eligibility criteria:
inclusion criteria: * female and male patients suffering from peripheral arterial occlusive disease with indicated interventions via an transbrachial access (puncture of the left or right brachial artery) * age \> 18 years * approval to participate exclusion criteria: * unability or refusal to participate * dialysis patients/av-fistula interventions * usage of closure devices

Keywords: transbrachial access, intervention, bleeding, hematoma
the association between intraoperative hypotension and perioperative stroke

Conditions: Perioperative Complication; Intraoperative Hypotension

Summary: the aim of this study is to investigate the association between the severity and duration of intraoperative hypotension and the incidence of perioperative stroke after non-cardiac and non-neurologic surgeries.the secondary aim of this study is to confirm the potential risk factors of the perioperative stroke.

optimized intraoperative management may play an important role in perioperative stroke prevention. maintaining blood pressure near preoperative baseline values may help decrease the incidence of stroke, however the related evidence is limited.therefore, this study is to investigate the association between intraoperative hemodynamic variable and the risk of perioperative stroke after non-cardiac and non-neurologic surgeries. the secondary aim of this study is to establish the potential risk factors of the perioperative stroke.

Eligibility criteria:
inclusion criteria: 1. patients underwent surgeries in first hospital affiliated to shandong first medical university from january 2013 to october 2019 2. age\>18 or older exclusion criteria: 1. patients received local infiltration anesthesia 2. patients underwent total intravenous anesthsia without tracheal intubation or laryngeal mask airway insertion 3. major vascular operation 4. neurologic surgery 5. cariac surgery 6. intraoperative blood pressure measurements or postoperative neuroimagings measurements are not available 7. history of severe neurological or psychiatric disease
application of watson for oncology in hepatocellular carcinoma surgery

Conditions: Liver Resection

Summary: the aim of this study was to evaluate the surgical decisions of watson artificial intelligence in patients with hepatocellular carcinoma.

hepatectomy is an effective treatment for patients with hepatocellular carcinoma, but liver failure after hepatectomy may lead to increased postoperative mortality. therefore, it is very important to make preoperative surgical decisions, evaluate the safety of the operation and identify which patients are likely to suffer from liver failure. the artificial intelligence platform developed by ibm watson for watson tumor treatment decisions can provide treatment decisions and corresponding theoretical basis to guide surgical decisions based on the key clinical data of liver cancer patients.

Eligibility criteria:
inclusion criteria: 1. 18 years≤ age ≤80 years 2. compling with the diagnosis criteria of complex hepatic carcinoma. 3. primary hepatic carcinoma without intrahepatic or extrahepatic extensive cancer metastasis, the metastatic hepatic carcinoma whose primary focal has been controlled 4. preoperative liver function is child - pugh grade a or b. 5. the patients are volunteered for the study. exclusion criteria: 1. patients with mental illness. 2. patients can't tolerate the operation owe to a variety of basic diseases (such as severe cardiopulmonary insufficiency, renal insufficiency, cachexia and blood system diseases, etc.) 3. the patients refused to take part in the study. 4. there are other co-existed malignant tumors. 5. benign liver diseases

Keywords: watson artificial intelligence hepatocellular carcinoma surgical decisions
a study of taspoglutide versus placebo for the treatment of patients with type 2 diabetes mellitus inadequately controlled with metformin plus pioglitazone.

Conditions: Diabetes Mellitus Type 2

Summary: this 3 arm study will assess the efficacy of taspoglutide on glycemic control (as assessed by hba1c) in patients with type 2 diabetes mellitus inadequately controlled with metformin plus pioglitazone, compared to placebo after 24 weeks of treatment. patients will be randomized to one of 3 treatment arms: taspoglutide 10mg once weekly, taspoglutide 20 mg once weekly (after 4 weeks of taspoglutide 10 mg once weekly) or placebo, in addition to their continued stable metformin plus pioglitazone treatment. after the first 24 weeks patients on placebo will be switched to taspoglutide 10mg once weekly or taspoglutide 20mg once weekly (after 4 weeks of taspoglutide 10mg once weekly. the anticipated time on study treatment is 1-2 years, and the target sample size is 100-500 individuals.


Eligibility criteria:
inclusion criteria: * adult patients, 18-75 years age; * type 2 diabetes receiving pioglitazone (\>= 30 mg/day) and metformin (\>= 1500 mg/day) for at least 12 weeks prior to screening; * hba1c \>=7.0% and \<=10.0% at screening; * bmi \>= 25 (\>23 for asians) and \<=45 kg/m2 at screening; * stable weight +/-5% for at least 12 weeks prior to screening. exclusion criteria: * history of type 1 diabetes mellitus or acute metabolic diabetic complications such as ketoacidosis or hyperosmolar coma in the previous 6 months; * evidence of clinically significant diabetic complications; * clinically symptomatic gastrointestinal disease; * myocardial infarction, coronary artery bypass surgery, post-transplantation cardiomyopathy or stroke within the previous 6 months; * known hemoglobinopathy or chronic anemia.
an efficacy and safety study of rimonabant for treatment of nonalcoholic steatohepatitis (nash) in patients without diabetes

Conditions: Fatty Liver

Summary: the purpose of this study is to assess the effect of rimonabant treatment on the histological features of nonalcoholic steatohepatitis (nash).

the total duration per patient will be approximately 28 months including a 24-month double-blind treatment period.

Eligibility criteria:
inclusion criteria: * patients with diagnosis of nash exclusion criteria: * excessive alcohol use * presence of diabetes mellitus * other chronic liver disease * previous or current hepatocellular carcinoma * use of medication known to cause steatosis * previous bariatric surgery * pregnancy or breastfeeding * presence of any severe medical or psychological condition that, in the opinion of the investigator, would compromise the patient's safe participation including uncontrolled serious psychiatric illness such a major depression within the last 2 years, and history of other severe psychiatric disorders. the above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Keywords: nash chronic liver disease
innovative physiotherapy in stroke rehabilitation

Conditions: Stroke, Ischemic; Stroke Hemorrhagic

Summary: the current study has the potential to improve rehabilitation during the subacute phase of a stroke, aiming to reduce the individual's disabilities and risk of falling, enhance health promoting physical activity and independence in adl.

the purpose of the rct is to investigate the effects of an innovative physiotherapy intervention, called i-coredist when applied in comprehensive rehabilitation after discharge from a stroke unit and throughout the rehabilitation chain.the project investigate: 1) effects on postural control and balance in various positions and functional activities. effects on and level of physical activity, and 2) user's identifications of positive and negative features in content and coordination of physiotherapy integrated in post stroke rehabilitation. function parameters of balance, gait and levels of physical activity at baseline and at 12 weeks will be compared to those obtained from the standard care group. semistructured interviews will be conducted to identify patients' perceptions of key positive and negative features of content and coordination of i-coredist and standard care rehabilitation after a stroke.

Eligibility criteria:
inclusion criteria: * a stroke diagnosis * can sit for 10 seconds without support * age 18-85 * trunk impairment scale-norwegian version (tis-nv) \< 15 * pre-stroke modified ranking scale (mrs) 0-3 exclusion criteria: * dementia * unable to cooperate in physiotherapy * on-going substance abuse * severe co-morbidity preventing rehabilitation, severe neurological diseases such as parkinson disease, multiple sclerosis and brain tumor.

Keywords: physiotherapy rehabilitation trunk stability stroke sub-acute innovative randomized controlled trial qualitative study gait balance
observational study on rotavirus gastroenteritis epidemiology, impact of lyophilised vs. liquid formulation of rotarix™

Conditions: Infections, Rotavirus

Summary: the aim of this study is to monitor any impact in the change from the lyophilised formulation to the liquid formulation of the rotarix™ vaccine on hospitalisations for rotavirus gastroenteritis. this is planned to be assessed by comparing trends of hospitalisations due to laboratory confirmed rotavirus gastroenteritis in children \<=5 years of age, before and after introduction of the liquid formulation of the vaccine in belgium.


Eligibility criteria:
inclusion criteria: all subjects must satisfy all the following criteria at study entry: * child aged ≤5 years with opportunity to receive lyophilised or liquid formulation of rotarix™; * hospitalised at one of the participating centres in belgium; * a stool sample has been provided for a rotavirus detection test during the study period; * laboratory test result of rotavirus is available. exclusion criteria: • none.

Keywords: rotarix™ observational ecological
geriatric assessments in elderly diffuse large b-cell lymphoma

Conditions: Lymphoma, Large B-cell, Diffuse

Summary: this study investigate the impact of comprehensive geriatric assessments using activity of daily living (adl), instrumental activity of daily living (iadl), and charlson's comorbidity index (cci) on survival and toxicities in korean patients with diffuse large b-cell lymphoma (dlbcl) treated with r-chop.


Eligibility criteria:
inclusion criteria: * patients with newly diagnosed cd20+ dlbcl * 65 years old or over * scheduled to receive r-chop chemotherapy * informed consent exclusion criteria: * other histology than cd20+ dlbcl * primary central nervous system dlbcl * patients with a diagnosis of cancer (other than basal or squamous cell carcinoma of the skin, cervical carcinoma in situ, well differentiated thyroid cancer \[papillary or follicular thyroid cancer\]) within 3 years before the study entry or with any treatment for cancer within 3 years before entry * consent withdrawal

Keywords: geriatric assessment diffuse large b-cell lymphoma activity of daily living instrumental activity of daily living charlson's comorbidity index
psychological and lifestyle factors on health outcomes

Conditions: Psychological; Stress; Immune Health; Vaccination; Respiratory Tract Infections; Injury

Summary: psychosocial and lifestyle factors in army recruits likely contribute to increased susceptibility to infection and injury during basic army training. the primary aim of this study is to assess the influence of psychosocial and lifestyle factors at the start of basic army training on immune health (e.g. respiratory infection and antibody response to influenza vaccination) and injury during training, in an observational design. a secondary aim is to establish whether changes in psychosocial and lifestyle factors during training impact immune health (e.g. response to hepatitis b vaccination). using an interventional design, participants will be randomly allocated into two experimental groups: (i) routine vaccination group: to receive first hepatitis b vaccination at initial medical assessment upon entry to basic training and second hepatitis b vaccination 1 month later; (ii) delayed vaccination group: to receive first hepatitis b vaccination during week 5 of training and second hepatitis b vaccination 1 month later.


Eligibility criteria:
inclusion criteria: men and women aged 16-33 years enrolled in phase one british army training exclusion criteria: -
correct: community registry study evaluating dupuytren's contracture treatment

Conditions: Dupuytren's Contracture

Summary: this observational study will prospectively collect data on treatment options, patient/investigator satisfaction, requirement for retreatment or additional treatment, and long-term outcomes of 3 treatment modalities(xiaflex, fasciectomy, or fasciotomy/needle aponeurotomy) in patients with dupuytren's contracture. in addition, this study will provide additional health economics and utilization data.

this is a prospective, multi-center, observational study. patients will be recruited based on the usual care presentation at each investigative site, as regular practice would dictate. consecutive patients deemed eligible for the study by their physician will be invited to participate during their usual care visit. enrolled patients will receive evaluations and treatment for dupuytren's contracture according to the standard of care and clinical practice at each study site. no study-specific visits will be required as part of the study. treatment and follow-up visits will be determined by the treating physician. treatments received for dupuytren's contracture will be recorded (ie, xiaflex, fasciectomy, or fasciotomy/needle aponeurotomy), including initial treatment and any subsequent therapy. the full prescribing information and medication guide for xiaflex is provided in this protocol as reference (appendix b). patient data (including treatment outcomes, joint contracture measured by the treating physician, and evidence of recurrence) and health care resource utilization data will be drawn from the patients' medical records, examination, and patient interviews. these data will be recorded via a web-based electronic data collection (edc) system. pros will be collected by self-completed questionnaires given to each patient via web-based data collection or telephone interviews. the site will follow up with the patient according to usual practice. information from the patient's visit may include goniometry and the physician's assessment of treatment outcome and healthcare utilization. patients will be considered enrolled in the study for a maximum of 4 years post-enrollment or until death, withdrawal of consent, loss to follow-up, or study closure.

Eligibility criteria:
inclusion criteria: * women or men 18 years of age or older * patients with a dupuytren's contracture of at least a single joint and a desire for correction * patients who are able to read and understand english * patients who are capable of understanding and cooperating with the requirements of the study * patients who are willing and able to respond to the posttreatment assessments via telephone or internet * patients must provide written informed consent, indicating that they understand the purpose of and requirements of the study and are willing to participate in the study. exclusion criteria: * patients who decide not to pursue correction of the dupuytren's contracture.

Keywords: dupuytren contracture auxilium xiaflex
short term outcome of acute heart failure in diabetic and non diabetic patients

Conditions: Acute Heart Failure; Diabetes Mellitus

Summary: around 26 million people suffer from heart failure (hf) globally, and the prevalence is increasing with an increasing longevity, prevalence of risk factors, and improved survival in patients with cardiovascular diseases in egypt, hf is the primary cause of hospitalization among patients aged \> 65 years . hospitalization for hf is associated with a high mortality and rate of re-hospitalization . around 75% patients with hf have ≥ 1 comorbidity, and these comorbidities make overall clinical outcomes worse . in a recent meta-analysis, patients with diabetes mellitus (dm) were suggested to have a two-fold increase in the risk of hf . dm is present in \~ 35% patients hospitalized with acute hf . multiple factors such as ischemia, hypertension, and extracellular fluid volume expansion are involved in the pathogenesis of hf in dm.

the prevalence of both heart failure (hf) and diabetes has increased over the last decades and is expected to do so in the upcoming decades . therefore, the presence of diabetes in patients with hf is also likely to increase and this is anticipated to become a major health concern. the actual prevalence of diabetes in patients with acute hf in different registries has varied but may be as high as 45% . because the structure and function of the heart is directly influenced by the presence of diabetes, diabetes is to be considered to represent more than just a co morbid condition in hf . diabetes has been shown to be an independent risk factor for the development of hf . moreover, this risk has been shown to be age and sex dependent. compared with patients without diabetes, the presence of diabetes doubles the risk of hf in men, and the risk of developing hf in women may be as much as four times higher . these associations may even be stronger in younger patients. furthermore, the presence of diabetes has been associated with a longer duration of hospitalization and higher rates of rehospitalization among patients with acute hf. importantly, in patients with hf, it has been established that the presence of diabetes is not only associated with an increased cardiovascular morbidity but also with an increased mortality

Eligibility criteria:
inclusion criteria: * aged 18 years old or older . * admitted to the coronary care unit with acute hf. * patients with new onset heart failure. * decompensated chronic hf. exclusion criteria: * aged under 18 years old. * patients with chronic hf