Kornimate/medical-research-clean huggingface dataset:
tai chi for stroke rehabilitation on balance and cognition

Conditions: Stroke

Summary: tai chi, an ancient chinese martial art, is a low intense aerobic exercise characterized by continuous movements that embrace the mind, body, and spirit. tai chi addresses the integration and balance of mind and body using the fundamental principles of slow, smooth, and continuous movement control, and the transfer of body weight while maintaining an upright and relaxed posture. the present randomized clinical trial project aims to apply the suggested principles as the typical features of tai chi applied stroke rehabilitation, and to evaluate the effects on physical (balance), psychological, and cognitive function.

cerebrovascular disease is a major global concern. the individuals with stroke would suffer from disease associated symptoms which influence their functioning in everyday life. these symptom clusters were usually known to be sharing similar underlying mechanisms. it is clear that the development of effective stroke rehabilitation involves interdisciplinary team approach to manage physical, social, cognitive, and psychological functioning in this population. tai chi, an ancient chinese martial art, is a low intense aerobic exercise characterized by continuous movements that embrace the mind, body, and spirit. tai chi addresses the integration and balance of mind and body using the fundamental principles of slow, smooth, and continuous movement control, and the transfer of body weight while maintaining an upright and relaxed posture. the newly developed style of tai chi for health programs is the seated tai chi, which shares the common tai chi principles while being modified to adjust the movements for patients with limited mobility. the present randomized clinical trial project aims to apply the suggested principles as the typical features of tai chi applied stroke rehabilitation, and to evaluate the effects on physical (balance), psychological, and cognitive function. only a few studies ever addressed the feasibility of tai chi for stroke rehabilitation, and the relationship between cognition and balance in this population is still very early stage of investigation. the main purpose of our collaborating project is to explore the direct relationship between cognition and balance in stroke patients during their rehabilitation process.

Eligibility criteria:
inclusion criteria: * diagnosed as stroke at least for 3 months upto 2 years * eligible to participate rehabilitation therapy referred by primary physician exclusion criteria: * not able to understand questionnaires * not able to stand alone for balance test

Keywords: stroke tai ji postural balance cognition
sepsis metabolomics

Conditions: Normal Control; SIRS; Sepsis; Severe Sepsis; Death

Summary: the occurrence of sepsis and its relevant multiple organ dysfunction remain a major problem in intensive care units with high morbidity and mortality. the differentiation between non-infectious and infectious etiologies, severity and organ function evaluation, and prognostic assessment are all challenging in routine clinical practice. many biomarkers have been suggested for these purpose; however sensitivity and specificity even of high-ranking biomarkers still remain insufficient. recently, metabolic profiling has attracted interest for biomarker discovery. in this study, lc-ms/ms will be perform to identify serum metabolic biomarkers for differentiation of sirs/sepsis, severity and organ function evaluation, and prognostic assessment among 65 patients. the investigators enrolled 35 patients who were diagnosed with sepsis, 15 patients who were diagnosed with sirs, and 15 normal patients. moreover, the sepsis were further divided into sepsis, severe sepsis, and sepsis patients before death. small metabolites that were present in patient serum samples were measured by lc-ms/ms techniques and analyzed using multivariate statistical methods, such as principal component analysis (pca), partial least squares-discriminant analysis (pls-da), and orthogonal partial least squares discriminant analysis. based on the multivariate statistical analysis above, the investigators could distinguish sepsis from normal and sirs; distinguish the difference among sepsis, severe sepsis and death. we hypothesis that some metabolites as identified in this study are promising biomarker candidates in the field of sepsis diagnosis and treatment.


Eligibility criteria:
inclusion criteria: * male and female aged 18 years old and over; * clinically confirmed infection; * fulfilled at least two criteria of systemic inflammatory response syndrome * core temperature higher than 38 °c or lower than 36 °c * respiratory rate above 20/min, or pco2 below 32 mmhg * pulse rate above 90/min, and * white blood cell count greater than 12,000/μl or lower than \< 4,000/μl or less than 10% of bands. exclusion criteria: * younger than 18 years of age; * acquired immunodeficiency syndrome; * reduced polymorphonuclear granulocyte counts (\< 500 μl-1); * died within 24h after admission into the icu, or refused to participate in the study, or declined treatment during the period of observation.

Keywords: metabolomics serum sepsis biomarkers
radiofrequency ablation of paroxysmal supraventricular tachycardia using a novel catheter equipped with mini electrodes

Conditions: Paroxysmal Supraventricular Tachycardia

Summary: paroxysmal supraventricular tachycardia is treated with radiofrequency ablation recently. this procedure is performed by ablating slow pathway or accessory pathway using radiofrequency ablation catheter. recently developed mirofidelity (mifi) catheter has mini-electrodes that can record local eletrogram with higher resolution. we aimed to investigate the efficacy of mifi catheter in the ablation of paroxysmal supraventricular tachycardia compared to conventional radiofrequency ablation catheter. enrolled patients undergo conventional electrophysiologic study. patients with sustained supraventricular tachycardia during the study are randomized to either study group or control group. radiofrequency ablation is performed using mifi catheter in the study group, and conventional catheter (blazer ii) in the control group. the study endpoints are recorded immediately after ablation and there is no additional follow up or management after procedure.


Eligibility criteria:
inclusion criteria: * patients who are scheduled to undergo radiofrequency ablation for paroxysmal supraventricular tachycardia or wpw syndrome with atrial fibrillation * give written informed consent for the study exclusion criteria: * unable to induce supraventricular tachycardia during electrophysiologic study. * cognitive impairment to understand study procedure
coughing in infratentorial brain lesion patients

Conditions: Stroke

Summary: to record diaphragm excursion in infratentorial brain lesions patients with dysphagia during coughing and compare them to those with supratentorial brain lesion patients with dysphasia and those with no dysphagia at a university affiliated rehabilitation department.

our previous work has shown that stroke patients with dysphagia have impaired diaphragm excursion in comparison to those with no dysphagia. it has been postulated that respiratory and cough function are primarily controlled by respiratory and swallowing centers located in the brainstem.we postulated that those with infratentorial brain lesions would have more impaired cough and respiratory function than those with non-brainstem lesions and supratentorial brain lesions. however there has been no studies whether those with infratentorial brain lesions have more impaired cough function and decreased diaphragm excursion than those with supratentorial brain lesions.

Eligibility criteria:
inclusion criteria: group 1- brainstem lesion subjects with dysphagia that would require insertion of a nasogastric tube group 2- non-brainstem lesion subjects with dysphagia that would require insertion of a nasogastric tube group 3- stroke patients with no evidence of dysphagia exclusion criteria: * episode of acute pneumonia or pulmonary embolism at time of enrollment * previous history of chronic respiratory disorders or other systemic disorders that may affect respiratory function ( ex, rheumatoid arthritis, chronic renal disease, spinal cord injury) * stroke patients with multiple brain lesions * episode of diaphragm weakness due to peripheral polyneuropathy or unilateral phrenic nerve palsy * previous episode of abdominal or thoracic surgery within one year of enrollment * concomitant diagnosis of myopathy, muscular dystrophy or other disorders that may affect respiratory muscles. * episode of rib fracture within one year of enrollment * chronic alcoholism * patient with previous diagnosis of dementia or with impaired cognitive function that may limit full participation at the evaluation * patient with tracheostomy state

Keywords: brainstem diaphragm deglutition disorder sonography
one-stop prep care pathway to simplify prep delivery in kenya: the one-stop prep care project

Conditions: HIV Infections

Summary: the goal of this cluster randomized study is to understand if using a one stop prep delivery model can improve the efficiency of prep service delivery, reduce the cost of providing prep and allow continuation on prep. the investigators will evaluate data from men and women ≥15 years of age unknown to be living with hiv seeking prep services at public health facilities in western kenya.

this study will evaluate the effectiveness of one-stop prep services in 12 public health facilities in kenya. the core implementation strategies to optimize one-stop prep care will include training of healthcare providers, technical assistance, joint clinic supervision with the county health officials, and abstraction of program data regarding prep initiations and continuations including characteristics of prep users for quality improvement. within this large program, the study team will recruit a nested observational cohort to obtain detailed complementary individual clinical, behavioral, and mental health outcomes (including for clients who discontinue prep).

Eligibility criteria:
inclusion criteria: * ≥15 years of age * accessing prep services at implementing clinics. * eligible for prep per kenya national guidelines for in-depth and key delivery informant interviews * able and willing to provide consent * provides services at participating clinics (healthcare providers) * key policy maker

Keywords: prep hiv prevention prep adherence sexual behavior
chemoradiation with oxaliplatin and fluorouracil (5fu) for locally advanced pancreatic cancer

Conditions: Pancreatic Cancer

Summary: the intention of this trial is to determine the maximum tolerated of the treatment combination and to evaluate its safety and efficacy.

previous studies have demonstrated that neoadjuvant chemoradiation can lead to improved survival with a portion of patients proceeding to resection. this trial will incorporate a similar trial structure using newer agents in patients who present with locally advanced unresectable pancreatic cancer. specifically oxaliplatin will be used owing to its greater activity in comparison to cisplatin and favorable therapeutic index in combination with radiation compared to gemcitabine. in summary, the primary outcome measure of the phase i portion of the trial is to determine the maximum tolerated dose of this combination. following the determination of this dose, the phase ii portion of the trial will characterize the toxicity of this regimen as well as evaluate for long-term efficacy.

Eligibility criteria:
inclusion criteria: * pathologically documented pancreatic adenocarcinoma deemed unresectable due to local involvement of vessels or organs * patients with a clear clinical diagnosis of localized pancreatic cancer deemed unresectable, who have undergone at least 2 biopsies which were not diagnostic of adenocarcinoma, may be entered at the discretion of the principal investigator. * no prior chemotherapy or abdominal radiation therapy. * eastern cooperative oncology group (ecog) performance status 0-1 * clinically measurable or evaluable disease. * life expectancy of at least 12 weeks. * adequate bone marrow reserve, granulocyte count \>= 1500/ul, platelet count \>= 100,000/ul, hemoglobin \>= 9 g/dl. * adequate renal function with creatinine =\< 1.5 times upper limit of normal (uln) * adequate biliary function with bilirubin \< 3.0 g/dl (including patients who have been bypassed or treated with percutaneous drainage), serum glutamic pyruvic transaminase (sgpt) (alanine transaminase) =\< 2.5 * age \> 18 years * signed informed consent. * no known allergy to one of the study drugs * for female patient of childbearing potential, neither pregnant nor breastfeeding, and under active contraception * no prior malignancy within last 5 years * no central nervous system metastases * no peripheral neuropathy \> grade2 * no other serious concomitant illness exclusion criteria: * active infection or uncontrolled infection * presence of metastatic disease. * inadequate organ function as discussed above. * pregnancy * serious concomitant systemic disorder. * use of any investigational agent within a month of treatment

Keywords: locally advanced pancreatic cancer oxaliplatin chemoradiation 5fu
efficacy and safety of vildagliptin compared to acarbose in drug naive patients with type 2 diabetes

Conditions: Diabetes Mellitus, Type 2

Summary: this study is not being conducted in the united states. the purpose of this study is to assess the safety and effectiveness of vildagliptin, an unapproved drug, compared to acarbose in lowering overall blood glucose levels in people with type 2 diabetes who have not been previously treated with drug therapy to lower their blood sugar.


Eligibility criteria:
inclusion criteria: * not currently on drug therapy for type 2 diabetes * body mass index (bmi) in the range 20-40 * blood glucose criteria must be met exclusion criteria: * pregnancy or lactation * type 1 diabetes * evidence of significant diabetic complications * evidence of serious cardiovascular conditions * laboratory value abnormalities as defined by the protocol * other protocol-defined exclusion criteria may apply.

Keywords: type 2 diabetes vildagliptin
breathid 13c-methacetin breath test for detecting cirrhosis

Conditions: Chronic Liver Disease

Summary: this trial is a pivotal trial to validate the use of a 13 c labeled substrate called methacetin and the breathid automatic breath testing system, for determination of cirrhosis in patients with chronic liver disease.

patients with chronic liver disease who have a recent biopsy will be offered a breath test. correlation will be shown between histology and breath test in determining cirrhosis.

Eligibility criteria:
inclusion criteria: * age \>18 with chronic liver disease exclusion criteria: * patients that are taking hepatotoxin drug. * patient with severe congestive heart failure * patient with severe pulmonary hypertension * patient with uncontrolled diabetes mellitus * patient with previous surgical bypass surgery for morbid obesity * patient with extensive small bowel resection * patient currently receiving total parenteral nutrition * patient is a recipients of any organ transplant * patients that received any anti-viral treatment within the past year * women who are pregnant * patient allergic to acetaminophen (such as tylenol or any other related medications) * patient with history of chronic obstructive pulmonary disease or symptomatic bronchial asthma * patients unable to sign informed consent * patients that based on the opinion of the investigator should not be enrolled into this study * patients that are participating in other clinical trials evaluating experimental treatments or procedures

Keywords: methacetin breath test cirrhosis
dental caries management by risk assessment: identification and treatment of risk factors among (idf) personnel

Conditions: Dental Caries

Summary: our study is designed as an interventional prospective longitudinal study which examines the israeli defense force personnel. the population of our study is composed out of the idf personnel which will be randomly be subdivided into 2 different groups - one will be noted as the intervention group and the other will function as a control group. each participant will be monitored for a period of 18 months.

on the intervention group, which includes a couple of hundreds participants, a thorough caries management by risk assessment plan will be conducted. the risk assessment will include the following criteria: * saliva check * plaque control * plaque acidity * diet - frequency of carbohydrate intake * previous caries experience and present carious activity * others (prosthetic/orthodontic appliances, systemic diseases etc.) after obtaining the data the patients will be categorized into 1 of 3 distinct risk level - low, medium, high. each category will be treated according to a tailored treatment protocol: * dietary instructions * oral hygiene instructions * antibacterial therapy * fluorides * restoration * follow ups the control group will be treated according to standard protocol of treatment in the idf dental clinics, which is based on removal the cavitated lesions, and lacks any reference to caries as a multifactorial infectious disease. we assume that personalized treatment of the disease, based on identifying risk factors will lower the number of patients with active disease.

Eligibility criteria:
inclusion criteria: * informed consent exclusion criteria: * pregnancy * available for 18 month follow-up
this study is to assess the efficacy and safety of zd6474 in subjects with non-small cell lung cancer.

Conditions: Non-Small Cell Lung Cancer (NSCLC, Locally Advanced or Metastatic, Second-line

Summary: the purpose of this study is to assess the efficacy and safety of zd6474 in patients with nsclc after failure of prior platinum-based chemotherapy.


Eligibility criteria:
inclusion criteria: * histologic or cytologic confirmation of nsclc (locally advanced or metastatic, ib-iv) * failure of first-line platinum-based chemotherapy exclusion criteria: * mixed small cell or non-small-cell histology * bronchoalveolar carcinoma * prior chemotherapy or herbal preparations must be discontinued more than 4 weeks before the start of study therapy (6 weeks for nitrosoureas, mitomycin and suramin) * prior treatment with docetaxel
da qing offspring study

Conditions: Diabetes Mellitus; Cardiovascular Diseases (CVD); Offspring, Adult; Impaired Glucose Tolerance (Prediabetes); Prevention; Cancer; Comorbidity; Inter- and Transgenerational Inheritance

Summary: this is an observational study tracking families and offspring of three cohorts from the 1986 da qing study: newly diagnosed diabetes, impaired glucose tolerance, and normoglycemia groups. based on the original participants, the study will further include their spouses, first to third-generation offspring, and spouses of the offspring. general demographic information will be collected, and anthropometric measurements will be refined. a structured questionnaire will be used to gather disease history, family history of diabetes, and related information. comprehensive diabetes-related laboratory screening and complication assessments will be conducted. a standardized biobank will be established, including blood and urine samples from the da qing offspring study, to support future research on epigenetics, metabolomics, and other mechanisms.


Eligibility criteria:
inclusion criteria: * spouses of the original daqing diabetes prevention research population (igt), offspring 1 to 3 generations, and offspring spouses were included in the study, without special restrictions on subjects' gender, age, basic disease status, etc。 * conduct a death agent investigation for some deceased members. exclusion criteria: ▪people who are unwilling to participate in this study
regional registry-based biobank development and pharmacogenetic analysis in rheumatoid arthritis

Conditions: Rheumatoid Arthritis

Summary: aim of this project is the building-up of an integrated model of multidisciplinary research tools to support large-scale and high-quality disease-based studies.

biologics have revolutionized rheumatoid arthritis (ra) management, with a great impact on patient that justifies treatment with these high-cost drugs. nevertheless, timing and proper therapeutic decision making remain the main challenge in clinical practice. pharmacogenetics approach might open promising perspectives, increasing our understanding on genetic-related drug efficacy. nevertheless, to ensure feasibility and reliability of translational applications of this strategy in clinical practice, large population-based research studies represent a crucial key step. objectives major aim of this project is the building-up of an integrated model of multidisciplinary research tools to support large-scale and high-quality disease-based studies. the main targets of this proposal will be: * to develop a disease-based biobank, integrated with already established emilia-romagna regional ra registry, providing a large-scale prospective collection and storing of multiple biological samples * to perform a pharmacogenetic study analyzing a panel of gene variants potentially influencing the response to tumor necrosis factor (tnf) blockers. methods * biobank development. a step-wise plan will be considered for: designing biobank governance frame-work, defining standard operating procedures, implementing information system resources. all these procedures will be applied for collecting, processing and storing biological samples of patients included in regional ra registry. * pharmacogenetic study. a panel of candidate gene variants will be studied in genomic dna from 300 patients enrolled in the regional ra registry. the association between genotypes and response to biological drugs will be assessed by data-mining approach, and a predictive model will be defined. expected results this proposal will create a disease-based biobank, tightly integrated with the already established emilia-romagna regional ra registry, and pave the way towards personalized therapy applications in rheumatology.

Eligibility criteria:
inclusion criteria: 1. diagnosis of arthritis rheumatoid according american college of rheumatology (acr)1987 or according acr/european league against rheumatism (eular) 2010 criteria 2. patients with new diagnosis or patients already diagnosed with active disease \[with disease activity score (das) 28 \> o = 4,2\] or patients switching therapy 3. male and female patients of minimum 18 years old 4. provision of informed consent exclusion criteria: 1) patients living outside emilia romagna region

Keywords: rheumatoid arthritis
weight gain prevention

Conditions: Weight Gain

Summary: the specific aim of the proposed project is to test two separate self-regulation interventions to prevent weight gain in young adults, one based on making sustained small changes in behavior to prevent weight gain and the other on making periodic larger behavior changes resulting in weight loss.


Eligibility criteria:
inclusion criteria: * age 18-35 * body mass index between 23 and 30 * interested in preventing weight gain exclusion criteria: * bmi outside of range specified * age outside of range specified * history of or current eating disorder or substance abuse * recent weight loss greater than 5% of weight * currently in another research study that would interfere

Keywords: overweight prevention of weight gain young adults self-regulation daily weighing weight gain prevention