Kornimate/medical-research-clean huggingface dataset:
rivaroxaban estimation with warfarin in atrial fibrillation patients with coronary stent implantation study (rewraps)

Conditions: Coronary Artery Disease; Atrial Fibrillation; Stroke; Fetal Blood Loss; Major Bleeding; All Cause Mortality

Summary: antiplatelet therapy is indispensable for the prevention of stent thrombosis in patients who underwent coronary artery stenting. similarly, anticoagulant therapy is essential for the prevention of cardiogenic embolism including cerebral infarction in af patients. however, the combined antithrombotic therapy has been reported to increase the risk of major bleeding for af patients after coronary stenting, new anticoagulant drugs that hardly interact with other drugs and do not need frequent blood tests have become commonly used. the purpose of this study is to assess the hypothesis that rivaroxaban is non-inferior to warfarin in the efficacy and safety for af patients after coronary stenting


Eligibility criteria:
inclusion criteria: clinically stable atrial fibrillation (af) patients who underwent coronary artery stenting more than one year ago and are treated or are scheduled to be treated with anticoagulant drug (regardless of the type of stents and af). those who are willing to cooperate with us in the study. those who can sign the informed consent document that is approved by the ethics committee of the medical institution participating in the study. exclusion criteria: those in whom the package inserts state anticoagulant drugs are contraindicated for use those who are scheduled to undergo percutaneous coronary intervention or catheter ablation for af. those who have to continuously undergo dual antiplatelet due to a past history of stent thrombosis during the distant stage after stenting. those who have undergone prosthetic valve replacement for valvular disease. those who the physician in charge judges are ineligible for the study due to serious pathological conditions. those who are not willing to participate in the study.
iliac artery treatment with the invatec scuba™ cobalt chromium stent (intense)

Conditions: Peripheral Artery Disease

Summary: the purpose of this study is to determine the safety and effectiveness of the scuba™ stent in subjects with symptomatic claudication or rest pain and angiographic confirmation of de novo or restenotic lesions in the common and/or external iliac artery.

interventional revascularization strategies for peripheral arterial disease currently available include both surgical and endovascular approaches such as percutaneous transluminal angioplasty (pta), either as a stand-alone procedure or with the placement of a stent. cobalt-chromium (cocr) is an alloy that has been used safely in the manufacture of surgical implants for use in contact with blood, soft tissue and bone for over 10 years. this study will evaluate the scuba™ peripheral balloon-expandable cobalt chromium tent system in iliac arteries.

Eligibility criteria:
inclusion criteria: * presence of de novo or restenotic lesion(s), located in the common or external iliac artery with ≥50% stenosis * subject has lifestyle limiting claudication or rest pain, (rutherford- becker scale \[clinical category\] 2, 3, or 4) * target vessel reference diameter is 5mm - 10mm by visual assessment * target lesion length \< 130mm * subject has angiographic evidence of a patent femoral outflow artery in the target limb * subject has provided written informed consent * subject is able and willing to adhere to required follow-up visits and testing exclusion criteria: * subject has lesions in the common femoral artery (cfa), profundal femoral artery (pfa), or superficial femoral artery (sfa) that would require a staged procedure within 30 days of the index procedure (either before or after) * target lesion(s) has adjacent, acute thrombus * target lesion(s) is highly calcified or was previously treated with a stent * subject has a pre-existing target iliac artery aneurysm or perforation or dissection of the target iliac artery * subject has an abdominal aortic aneurysm contiguous with the iliac artery target lesion * subject has a post-surgical stenosis and anastomotic suture treatments in the native iliac vessel * subject has a vascular graft previously implanted in the native iliac vessel * subject has tissue loss - rutherford-becker clinical category 5 or 6 * history of neutropenia (wbc \<3,000/mm3), coagulopathy, or thrombocytopenia (platelet count \<80,000/ul) * international normalized ratio (inr) greater than 1.5 * serum creatinine greater than 2.5 mg/dl * subject has a known bleeding or hypercoagulability disorder or significant anemia (hb \< 8.0 g/dl) that cannot be corrected * subject is participating in an investigational study of a new drug, biologic, or device at the same time of study screening

Keywords: iliac artery stenting peripheral artery disease
chlorhexidine impregnated cloths to prevent skin and soft tissue infections in marine officer candidates

Conditions: Staphylococcus Aureus; Community-Acquired Infections; Staphylococcal Skin Infections

Summary: outbreaks of skin and soft tissue infections (ssti) related to community associated methicillin-resistant staphylococcus aureus (mrsa) have become increasingly common in military training units. risk factors for mrsa related ssti such as crowding, poor hygiene and shared equipment are often hard to avoid in a military training environment, often designed to simulate battlefield conditions. it has recently been demonstrated that military recruits colonized with mrsa may be at increased risk of developing ssti. studies in the hospital environment have shown that decolonizing inpatients known to carry mrsa decreases the rates of mrsa related infections in the treated individuals and also in their inpatient unit as a whole. the investigators propose a randomized, double blind, placebo controlled trial to: 1. evaluate the effectiveness, feasibility, and safety of chlorhexidine body cloths, self-administered three times weekly, in preventing ssti among recruits in military training facilities; and 2. evaluate the effectiveness of chlorhexidine body cloths in decreasing rates of staphylococcus aureus colonization among military recruits.


Eligibility criteria:
inclusion criteria: * enrolled in us marine officer candidates school * age 18-35 years * provide documented informed consent and hipaa authorization exclusion criteria: * is currently taking oral antibiotics and will continue to take antibiotics during the study (such as antibiotics used to treat acne) * has a known or suspected allergy or intolerance to chlorhexidine (hibistat, hibiclens) * is currently using certain skin products and is uninterested in stopping use of the products during the study * pregnant or breastfeeding

Keywords: mrsa staphylococcus aureus
the experience of affective touch in anorexia nervosa

Conditions: Anorexia Nervosa

Summary: the aim of the present research will be to verify if the pleasantness of affective touch is comparable between women with an and healthy women while measuring the level of social anhedonia and the lifespan experience of affective touch.


Eligibility criteria:
inclusion criteria: * right-handed * diagnosis of restricting type or binge-eating/purging type an, according to the diagnostic and statistical manual of mental disorders (5th edition)'s criteria (dsm, american psychiatric association, 2013). exclusion criteria: * concurrent neurological, neurodevelopmental (e.g., autism), motor, somatosensory and/or psychiatric disorders * evidence of any skin-related condition possibly affecting sensitivity on the participants' forearm (e.g., eczema, scars).

Keywords: affective touch social anhedonia lifespan bodily contacts interpersonal relationships
mesenteric infiltration in ovarian cancer

Conditions: Ovary Cancer

Summary: to evaluate if ct features at diagnosis in patients with hgsoc can be used to build an artificial intelligence model capable of discerning the pathological involvement of the mesentery, assessing the potential impediments for an optimal debulking surgery and predicting the development of resistance to platinum based chemotherapeutic agents.


Eligibility criteria:
inclusion criteria: 1. women with confirmed hgsoc wiht mesenteric involvment 2. age \> 18 years 3. figo stage iiib-iv 4. primary diagnosis 5. signed informed consent exclusion criteria: 1. non-serous high grade epithelial ovarian cancer (serous low grade, mucinous, clear cell carcinoma, endometrioid or non-epithelial ovarian cancer) 2. early stage disease (i and ii stage) 3. ct scan not available 4. non-primary diagnosis or patient subjected to neoadjuvant chemotherapy
case-control study- cancer pain: uncontrolled pain as depression development predictor in oncologic patients (fentanyl)

Conditions: Cancer Pain

Summary: the purpose of this study is to evaluate the relationship between cancer pain and risk of depression among cancer patients.

this is a retrospective observational and case-control multicenter study. the main objective of this study is determine the degree of association between cancer pain and depression by impact assessment of adequate control of pain associated with cancer risk depression in patients attending the oncology unit. the assessment of pain intensity will be performed by using visual analogue scales (evas) and verbal descriptive scales, as an observational study, not limit or modify the use of any drug. the patients included in this study have a medical history of cancer pain and mild depression (beck = 8). the controls are patients with history of cancer pain and mild or absent depression (beck = 7). n/a

Eligibility criteria:
inclusion criteria: * patients =18 years old * have medical data of = 3 months * experience pain after cancer diagnosis and complete the beck depression inventory (bdi) * patients who give informed written consent * patients with no mental or physical disorders that unable them to complete the bdi. exclusion criteria: * patients with diagnosis of depression before cancer diagnosis * patients with chronic pain prior to the diagnosis of cancer, and cancer disease has not changed its course * patients with other previous mental disorders * patients who do not give their informed written consent.

Keywords: cancer depression pain
reactiv8 for chronic low back pain (pmcf)

Conditions: Chronic Low Back Pain

Summary: the purpose of this clinical study is to investigate the effect of electrical stimulation for chronic low back pain.


Eligibility criteria:
inclusion criteria: 1. age ≥ 18 years, ≤65 years 2. chronic low back pain with a first occurrence \>90 days prior to enrolment, and the last relatively pain-free time \>90 days prior to enrolment. 3. continuing low back pain despite \>90 days of medical management 4. oswestry disability index score ≥25% and ≤60% at the time of enrolment 5. able to understand and sign the informed consent form. 6. ability to comply with the instructions for use and to operate the reactiv8, and to comply with this clinical investigation plan. 7. suitable for reactiv8 surgery as determined by the implanting physician prior to inclusion. 8. prior week average low back pain nrs of ≥6.0 and ≤9.0 on a 11 point nrs scale (0-10) at the baseline visit exclusion criteria: 1. bmi \> 35 2. back pain characteristics: 1. any surgical correction procedure for scoliosis at any time, or a current clinical diagnosis of scoliosis. 2. lumbar spine stenosis, as defined by an anterior-posterior diameter of the spinal canal of \<10mm in subjects with lower extremity pain 3. neurological deficit possibly associated with the back pain (e.g. foot drop). 4. back pain due to pelvic or visceral reasons (e.g.: endometriosis or fibroids) or infection (e.g.: post herpetic neuralgia). 5. back pain due to inflammation or damage to the spinal cord or adjacent structures (e.g. arachnoiditis or syringomyelia) 3. any current indication for back surgery according to local institutional guidelines, or has indication for back surgery but cannot undergo surgery for other reasons. 4. leg pain described as being worse than back pain, or radiculopathy (neuropathic pain) below the knee. 5. source of pain is the sacroiliac joint as determined by the investigator. 6. drug use 7. surgical and other procedures exclusions 8. any prior diagnosis of lumbar vertebral compression fracture, lumbar pars fracture, or lumbar annular tear with disc protrusion 9. planned surgery. 10. co-morbid chronic pain conditions 11. other clinical conditions 12. psycho-social exclusions 13. protocol compliance exclusions 14. general exclusions
screen of dm by ogtt in subjects receiving cag or mdct for cad

Conditions: Diabetes Mellitus; Coronary Artery Disease

Summary: to determine the glucose regulation status of patients who were suspected to have cad in central taiwan.

it had been reported that high prevalence of igt (impaired glucose tolerance) and unknown dm (diabetes mellitus) in patients with cad (coronary artery disease). this study aimed to determine the glucose regulation status of patients who were suspected to have cad in central taiwan. in general, patient who were admitted for cag (coronary angiography) or mdct without known dm were eligible. after informed consent, ogtt (oral glucose tolerance test) was performed to determine the glucose regulation status. study participants will be requested to complete questionnaires to assess their risk of diabetes and quality of sleep. patients who were diagnosed as new dm would be asked to follow up in clinical service with diet control.

Eligibility criteria:
inclusion criteria: * patient received cag or mdct for suspect cad * without dm history exclusion criteria: * known dm * unstable disease condition * pregnancy

Keywords: dm cad meal tolerance test
sensorimotor exercises in virtual reality platform in individuals with human t-lymphotropic virus

Conditions: HTLV-1

Summary: testing the effectiveness of an exercise protocol engines sensory performed through a virtual reality platform in individuals infected with htlv-1

crossover randomized clinical trial to be conducted with people having a previous diagnosis of htlv-1, they can remain in standing position without assistance. they will be excluded from those presenting amputation of the lower limbs, pregnancy, psychiatric disorders, rheumatic or orthopedic diseases, other neurological disorders associated and those that are experiencing difficulty in understanding the assessment tools used. they will also be recruited to a comparative group, healthy individuals, matched for sex, age and education level. it will be performed three assessments, before randomization, after 10 weeks and after 20 weeks, which will be evaluated in balance, functional mobility, gait and posture. the participants infected with htlv-1, will be divided into two groups by random distribution, a group will begin the treatment protocol with video game immediately after the first evaluation and the other after ten weeks, with the crossing of the groups . concealment of allocation will be guaranteed to the examiners who will have no contact with the physiotherapist who will apply the exercise protocol and the team member responsible for drawing. patients will also be instructed to maintain confidentiality of the entry in the exercise program to other patients and examiners.

Eligibility criteria:
inclusion criteria: * people having a previous diagnosis of htlv-1, which can remain in standing position without assistance. exclusion criteria: * amputation of the lower limbs, pregnancy, psychiatric disorders, rheumatic or orthopedic diseases, other neurological disorders associated and those that are experiencing difficulty in understanding the assessment tools used.
sterilizing eye solution to improve patient comfort (relief)

Conditions: Retinal Disease

Summary: this is a randomized, double-masked study to evaluate the tolerability and safety of irx-101 versus 5% povidone-iodine (pi) in subjects receiving intravitreal anti-vegf injections. the study will be conducted in up to 15 centers in the united states (us).


Eligibility criteria:
inclusion criteria: 1. capable of giving informed consent 2. stated willingness to comply with all study procedures and availability for the duration of the study 3. male or female, ≥ 18 years of age and receiving intravitreal anti-vegf injections in one or both eyes exclusion criteria: 1. current or past diagnosis of endophthalmitis 2. current diagnosis of uveitis 3. monocular patients (vision 20/100 or worse in one eye) who are receiving injections in the better seeing eye 4. current use of viscous lidocaine products for ocular anesthesia prior to ivt 5. currently receiving intravitreal steroid injections 6. concurrent participation in another clinical trial 7. females who are pregnant, planning to become pregnant or lactating
thoracal radiotherapy and tarceva

Conditions: Cancer

Summary: the purpose of this study is to determine if erlotinib given orally along with concurrent palliative irradiation to lung cancer improves local control compared to those treated with radiotherapy alone.

endpoints: primary: * to determine if erlotinib given orally along with concurrent external beam radiation therapy, prolongs local tumour control as determined by ct evaluation compared to treatment with external beam radiation therapy alone secondary: * to confirm the safety profile of erlotinib along with concurrent external beam radiation therapy. * to evaluate if erlotinib along with concurrent external beam radiation therapy, improve quality of life as assessed with the eortc qlq-c30 and the eortc qlq-lc13. * to evaluate if pet-ct examination can be used to predict response to treatment. * to evaluate overall survival in the different groups trial design: open multicenter two-armed randomized phase ii trial.

Eligibility criteria:
inclusion criteria: * age \>18 years * histological or cytological verified nsclc * palliative radiotherapy to thorax indicated * ecog performance status 0-2 * fertile patients must use contraception * signed informed consent * ability to understand and fill in qol questionnaires * capability to take per os medication * serum bilirubin \< 2 times upper limit of normal (uln) * ast and alt \< 2 times uln (\< 5 times uln if liver metastases are present) * creatinine \< 5 times uln exclusion criteria: * pregnancy or nursing * other prior or concurrent malignant disease likely to interfere with study treatment or comparisons * no evidence of other significant laboratory finding or concurrent uncontrolled medical illness, that in the opinion of the investigator, would interfere with study treatment or results comparison or render the patient at high risk for treatment complications * no prior radiotherapy to the same organ / place * no concurrent treatment with other experimental drugs * known brain metastases in need of radiotherapy * known hypersensitivity to erlotinib or other substances in the erlotinib tablets.
prism adaptation therapy for spatial neglect

Conditions: Spatial Neglect; Deficits in Attention Motor Control and Perception

Summary: the purpose of this research study with a randomized controlled design is to examine the effects of prism adaptation treatment on two visual-spatial recovery components. after a stroke, an "internal gps", locating where objects or people lie in a particular area of space, may be impaired. alternately, a stroke may impair precise visual-spatial hand and body aiming movements. the research team wishes to discover whether prism adaptation treatment (two weeks of daily 20-min sessions of goal-directed movement with prism goggles) affects visual-spatial where or aiming errors selectively after stroke. this research represents one of the first attempts to apply what we know about the brain from neuroscience research, to modern clinical rehabilitation practices.

the purpose of this research study with a randomized controlled design is to examine the effects of prism adaptation treatment on two visual-spatial recovery components. after a stroke, an "internal gps", locating where objects or people lie in a particular area of space, may be impaired. alternately, a stroke may impair precise visual-spatial hand and body aiming movements. the research team wishes to discover whether prism adaptation treatment (two weeks of daily 20-min sessions of goal-directed movement with prism goggles) affects visual-spatial where or aiming errors selectively after stroke. this research represents one of the first attempts to apply what we know about the brain from neuroscience research, to modern clinical rehabilitation practices.

Eligibility criteria:
inclusion criteria: * the subject is 18 to 100 years of age, inclusive. * the subject has had a stroke on the right side of the brain. * the subject is able to give informed consent. * the subject has a spatial neglect (if known). * the subject is able and willing to comply with the study protocol, including availability for all scheduled clinic visits. exclusion criteria: * the subject has or had a serious brain condition other than stroke.

Keywords: stroke cva cerebrovascular accident rehabilitation
incidence of pain after craniotomy in children

Conditions: Disruption or Dehiscence of Closure of Skull or Craniotomy

Summary: the primary objective is to assess the incidence and severity of pain after major craniotomy in paediatric patients (from 1 month to 10 years of age). the secondary objective is to determine factors associated with significant pain following paediatric neurosurgery .

research in the adult population has evaluated incidence and severity of post-neurosurgical pain, and effectiveness of different post-neurosurgical analgesic regimens. several small studies report the prevalence of some period of moderate to severe pain in the first 24 postoperative hours to be from 41 to 84 % of patients. in a prospective single academic medical institution study, adult patients treated with only acetaminophen and modest amounts of opioids on an as needed basis reported moderate to severe pain for the first 2 days after surgery. these findings have supported a growing consensus that perioperative pain associated with intracranial surgery may be more significant than initially appreciated. factors that have been associated with increased pain after intracranial surgery include sex, younger age, surgical site, and surgical approach to the site. pain may also be a significant factor in the quality of recovery from intracranial surgery. in contrast there are few studies describing the incidence or management of pain after neurosurgery in children.

Eligibility criteria:
inclusion criteria: * male and female children from 1 month to 10 years of age * american society of anaesthesiologists classification (asa) i-iii * scheduled for supratentorial or infratentorial craniotomy * admission to an intensive care unit, neurosurgery ward or paediatric ward of one of the hospitals included * children whose parents (or legal tutors) have given their informed written consent exclusion criteria: * emergency surgery for multiple trauma. * children requiring muscular relaxants during the postoperative period * children whose parents (or legal tutors) denied their own consensus

Keywords: craniotomy pain children