Kornimate/medical-research-clean huggingface dataset:
hypolipidemic and antioxidant capacity of spirulina and exercise

Conditions: Cardiovascular Diseases

Summary: the purpose of this study is to demonstrate that spirulina maxima intake and a dosed physical activity program will decrease, both independently and synergistically, cardiovascular risks (dyslipidemias and oxidative stress) in overweight and obese subjects.

cardiovascular diseases are the leading cause of death globally, being dyslipidemias, oxidative stress, sedentary lifestyle and obesity primary risk factors. as a way to reduce cardiovascular diseases risk factors, the intake of antioxidants that come from a fruit and vegetable-rich diet or nutritional supplements, have been proposed; in this sense, the cyanobacterium spirulina maxima is an important source of antioxidants, which is currently associated with cardiovascular protection properties. furthermore, physical exercise at moderated intensity has protective effect exerted against cardiovascular diseases risks, mainly due to physiological adaptations, including expression of antioxidant enzymes, which stop formation and propagation of radicals, improving redox status of the organism. there is evidence that spirulina maxima, in addition to exercise, decreases cardiovascular diseases risks, this was mainly observed in animal models. however, no studies in humans under spirulina maxima and exercise experimental designs proving these benefits are reported. therefore this study will analyze the independent and synergistic effect of the intake of spirulina maxima with a program of physical exercise at moderated intensity on general fitness, plasma lipid profile and antioxidant capacity in overweight and obese subjects. methods/design: through a randomized, double blind, placebo controlled, counterbalanced crossover study design, 80 healthy overweight and obese subjects will be assessed during a 12 week isoenergetic diet, accompanied by 4.5 g/day spirulina maxima intake and/or a systematic physical exercise program at moderate intensity. body composition, vo2 consumption, heart rate, blood lactate, plasma concentrations of triacylglycerols, total, low and high-density lipoprotein cholesterol, antioxidant status, lipid oxidation, protein carbonyls, superoxide dismutase, catalase, glutathione, glutathione peroxidase, glutathione reductase, and paraoxonase will be assessed. discussion: spirulina maxima and exercise are good alternatives to improve general fitness, to prevent or lessen dyslipidemia and oxidative stress in subjects with risk factor of chronic or noncommunicable diseases. however the independent and synergistic effect of spirulina maxima with exercise against dyslipidemias and stress in overweight and obesity is not yet known.

Eligibility criteria:
inclusion criteria: * overweight (body mass index (bmi): 25-29.9 kg/m2) and obese (bmi: \> 30 kg/m2) persons exclusion criteria: * taking drugs and/or food or vitamin supplements * diabetes * have a physical or electrocardiographic injury that prevents them from engaging in regular physical exercise
the association between periodontal disease and malnutrition in a group of elderly people in thailand.

Conditions: Periodontal Diseases; Malnutrition

Summary: this study will be determine the association between periodontitis and malnutrition status in older adult.

ageing may accompany with an accumulation of diseases and impairments cause by physiological, socioeconomic and psychological changes. the older adults are more prone to nutritional deficiencies due to combination of factors such as ageing, excessive polypharmacy, general health decline, poor socioeconomic status, cognitive decline, poor appetite, impaired efficacy of swallowing and limit eating ability. periodontitis is a multifactorial disease predominantly a bacterial infection involving the dental biofilm or dental plaque. periodontitis increases in extent and severity across a large proportion of the human population with ageing. the effects of ageing on the immune system include distinct alterations in both innate and adaptive immune-cell function and effector biomolecules, resulting in processes reflecting immunosenescence, immunoactivation and inflammaging. moreover, genetic contribution alters immunity and inflammation that play a role in the dysregulation of host responses in ageing. the combination of chronic antigenic burden and uncontrolled inflammatory response can enhance immunosenescence and ageing-associated disease. periodontitis also has an effect on food intake, nutritional status and quality of life in older adults. however the relationship between chronic periodontitis and malnutrition in older adult is not clear and needs further study. in this study will be determine the association between periodontitis and malnutrition status in older adult.

Eligibility criteria:
inclusion criteria: 1. subjects who has aged ≥ 60 years old. 2. subjects who not receive periodontal treatment within the previous 6 months. 3. subjects who are able to read thai and express verbal communication. 4. subjects who are functional independent older adults (get ≥ 12 points from barthel index for activities of daily living) \[50, 51\]. 5. subjects who are cognitive functional independent older adults (get \> 23 points from thai mental state examination) \[52\]. exclusion criteria: 1. subjects with completely edentulous area. 2. subjects who require antibiotic prophylaxis for dental examination

Keywords: periodontal disease malnutrition older adult
the effect of sodium bicarbonate on postoperative renal function in infective endocarditis patients undergoing open heart surgery

Conditions: Acute Kidney Injury

Summary: the purpose of study is to test whether perioperative sodium bicarbonate infusion can prevent acute kidney injury following open heart surgery in infective endocarditis patients.


Eligibility criteria:
inclusion criteria: * adult patients over the age of 20 scheduled for open heart surgery for infective endocarditis exclusion criteria: * end stage renal disease (serum creatinine concentration \> 300 μmol/l) * on dialysis * chronic moderate to high dose corticosteroid therapy (\> 10 mg/day prednisolon or equivalent) * preoperative severe hypernatremia (na+ \> 150 mmol/l), alkalemia (ph \> 7.50), or pulmonary edema * neurocognitive dysfunction

Keywords: sodium bicarbonate, renal function, infective endocarditis, open heart surgery
the effects of intra-articular platelet-rich plasma injection on the severity of knee osteoarthritis

Conditions: Osteoarthritis, Knee

Summary: this is a single-center, randomized control trial the aim of this study is to compare prp with placebo as the treatment of knee oa conducted at puri raharja hospital bali in january-june 2022 sample consisted of 106 patients with knee oa grades 2-3 kellgren-lawrence, randomized into prp group and placebo group samples were injected with 2 ml prp or normal saline twice at one-week interval the severity of knee oa was assessed by western ontario and mcmaster universities osteoarthritis index (womac) before injection and two weeks after the first injection.


Eligibility criteria:
inclusion criteria: patients with knee pain for at least three months, aged between 40 to 80 years old, and whose results of radiological examination of the knee indicated oa grades 2-4 based on the kellgren lawrence classification exclusion criteria: polyarticular rheumatic disease; knee arthroscopy \<1 year; intra-articular injection of hyaluronic acid (ha) or steroids in the past three months; current infection, diabetes, rheumatoid arthritis, coagulopathy disorders, anticoagulant or antiplatelet aggregation therapy, immunodeficiency disease, taking non-steroidal anti-inflammatory drugs (nsaids) two weeks prior to the procedure, knee trauma; inflammation; and tumors around the knee
extension study with tosedostat in relapsed/refractory acute myeloid leukemia

Conditions: Acute Myeloid Leukemia

Summary: the purpose of this study is to evaluate the long-term efficacy and safety profile of tosedostat in elderly patients suffering from refractory or relapsed acute myeloid leukemia.

extension protocol to the opal study (chr-2797-038). study mimics normal clinical practice; few procedures and visits are therefore mandated by the protocol. timing of bone marrow assessment is also left at the investigator's discretion.

Eligibility criteria:
inclusion criteria: * signed, informed consent * completion of visit 11 in the opal study (month 6 visit) * investigator's opinion that the subject would benefit from continued therapy with tosedostat. exclusion criteria: * any co-existing medical condition that in the investigator's opinion will substantially increase the risk associated with the subject's participation in the study * psychiatric disorders or altered mental status precluding understanding of the informed consent process and/or completion of the necessary studies * administration of any (other) investigational agent within 14 days of entry into topaz.

Keywords: relapse refractory acute myeloid leukemia
functional microarray augmentation of skin treatment with lidocaine

Conditions: Pain Perception; Phlebotomy

Summary: the purpose of this study is to determine whether co-application of a functional microarray of needles (fma) speeds the rate at which topical anesthesia is provided. a secondary goal is to determine whether the depth of anesthesia is enhanced.

the study's primary goal is to determine whether co-application of a functional microarray of needles (fma) speeds the rate at which topical anesthesia is provided by lidocaine gel 4% (lg4). a secondary goal is to determine whether the depth of anesthesia is enhanced.

Eligibility criteria:
inclusion criteria: age at least 18 years, must provide voluntary consent, weight at least 50 kg, no allergies to lidocaine, no skin disease, inflammation, or infection at the venipuncture sites to be tested exclusion criteria: cannot have any major dermatologic disease history, known liver abnormalities, women who are currently breastfeeding

Keywords: venipuncture phlebotomy pain perception
liver biopsy in diagnosis neonatal jaundice

Conditions: Neonatal Cholestasis; Neonatal Jaundice

Summary: 1. identification and characterization of histopathological features of liver in cases of pnj. 2. assessment of key histological features in liver biopsy as diagnostic parameters in differentiating intra-hepatic and extra-hepatic causes of pnj. 3. evaluation of role of liver biopsy as a diagnostic tool in conjunction with clinical and laboratory findings.

neonatal cholestasis (nc) is described as an early-life defect in bile production or flow that causes the liver to retain biliary substances. persistent neonatal jaundice (pnj) is the presence of variable degrees of jaundice, choluria and hypocholic or acholic stools for more than 10 days during early months of life. the rate of neonatal cholestasis is estimated to be 1 per 2,500 live births worldwide. in egypt, about 20.4% of full-term newborns develop jaundice yearly. extrahepatic cholestasis(ehc) and intrahepatic cholestasis(ihc) are the two main causes of persistent neonatal jaundice. this division is according to the presence or absence of extrahepatic obstruction to bile flow. biliary atresia(ba) and idiopathic neonatal hepatitis(inh) are the most frequent etiologies for ehc and ihc respectively. it is critical to identify the underlying cause of pnj in order to start the right surgical or medicinal treatment. early surgical referral is necessary in biliary atresia(ba) to increase success rates. in the case of treatable metabolic diseases, a prompt diagnosis justifies prompt, targeted therapy and a better prognosis. despite the development of new diagnostic means and advances in imaging techniques, non-invasive biomarkers and genomic studies, a liver biopsy done at the right time is still an important tool to evaluate and diagnose patients with cholestasis, as it will help to decide the etiology, the prognosis and eventually the treatment of the patient. the evaluation of liver biopsies in infantile cholestasis disorders is crucial as the histologic features of many of these disorders may overlap and vary with age.

Eligibility criteria:
inclusion criteria: * all cases presented with persistent neonatal jaundice in the first year of life in 5 years interval (2019-2023), received at surgical pathology laboratory at assiut university hospitals, egypt. exclusion criteria: * patients older than one year. * patients who underwent liver biopsy in the same age group but were not diagnosed as persistent neonatal jaundice. * patients with deficient clinical data.

Keywords: liver biopsy in neonatal jaundice neonatal cholestasis liver biopsy
massage in treating painful shoulder

Conditions: Shoulder Pain Syndrome; Pain; Frozen Shoulder

Summary: the purpose of this study is to compare classical massage and massage based on the tensegrity rule in treating people with painful shoulder.

the joint system of the shoulder girdle is exposed to frequent overloading, which can cause painful shoulder. the therapeutic methods applied in the treatment of painful shoulder syndrome include among others oral pharmacotherapy, joint injections, kinesitherapy, ultrasound, electrotherapy, laser. manual therapy, chiropractic and surgery could also be used. attempts have also been made to apply classical massage in treating painful shoulder, although it is not often used due to its low effectiveness.this study compares classical massage and massage based on the tensegrity rule which is not commonly known.

Eligibility criteria:
inclusion criteria: * painful shoulder syndrome exclusion criteria: * acute pain * previous bones fracture * bone relocations in the area of the shoulder girdle * neck spondylosis * hemiparesis * rheumatoid arthritis * any neurological symptoms

Keywords: massage shoulder pain range of motion restricted range of motion
resilience curriculum for novice physicians-in-training

Conditions: Stress, Emotional

Summary: to determine the feasibility of delivering a structured resilience curriculum to novice physicians-in-training, we propose a pilot study to evaluate recruitment rates, course attendance and compliance with follow-up surveys. if our study can demonstrate feasibility in course delivery, further engagement of postgraduate specialty programs will facilitate conduct of an appropriately powered randomised controlled trial.


Eligibility criteria:
inclusion criteria: * all first and second year medical residents enrolled in the schulich school of medicine \& dentistry anesthesia \& emergency medicine postgraduate residency programs. exclusion criteria: * none
symptom-limited stair climbing test in heart failure

Conditions: Chronic Heart Failure

Summary: aims: to assess the efficacy of symptom-limited stair-climbing test (slsct), in determining the exercise capacities of patients with chronic heart failure (chf) in comparison with cardiopulmonary exercise test (cpet) and 6-minute walk test(6mwt) and to interpret the results according to the clinical status of the patients. methods: thirty-one patients, aged 50-75 years, with stage ii-iii chf according to the new york heart association classification and left ventricular ejection fraction (lvef) of ≤45% were included. the demographic and clinical characteristics of the patients were recorded. exercise capacity was assessed by slsct, 6mwt, and cpet. the duration of patients' performance in the test, reasons for ending the test and predicted maximal oxygen consumption (vo2max) were recorded. heart rate (hr), blood pressure (bp), dyspnoea severity \[modified borg scale (mbs)\] and peripheral oxygen saturation were recorded. pulmonary functions were assessed by spirometry.


Eligibility criteria:
inclusion criteria: * 50-75 years of age * nyha stage ii-iii * lvef of 45% or less * independently walking and climbing stairs * volunteer to participate in research exclusion criteria: * any acute or chronic condition that would limit exercise capacity other than chf * insufficient mental status to perform tests and surveys * orthopaedic problem limiting exercise test in lower extremity * severe obesity or there is a secondary cause for obesity * uncontrolled cardiac arrhythmia * unstable angina

Keywords: chronic heart failure exercise capacity symptom-limited stair-climbing test
soft tissue ultrasound of infections

Conditions: Soft Tissue Infections; Cellulitis; Abscess

Summary: objectives: this study aims to characterize severe skin and soft tissue infections (sstis) in the emergency department through the acquisition of ultrasound images. a wide range of sstis will be imaged and recorded, leading to a registry of these infections. the registry will show whether ed (emergency department) sonographers can accurately characterize these infections, as compared to the final hospital diagnosis. the registry will also provide data for a case-control study comparing ultrasonographic characteristics of necrotizing skin and soft tissue infections (nstis) to those of non-necrotizing sstis. research procedures: in this study, the investigators will approach patients who present to the emergency department with a possible skin and/or tissue infection. study subjects must be ed patients requiring admission to the hospital for the primary problem of an ssti due to the need for follow-up. if the patient consents to participating in the study, the investigator will obtain and record an ultrasound image of the infected area. an ultrasound image of an uninfected area of skin will also be recorded for comparison. patient information regarding personal history, physical examination, blood tests and x-rays will also be gathered from participants.


Eligibility criteria:
inclusion criteria: * at least 18 years of age * ability to understand risks/benefits and consent to participation in the study * ability to read and understand english or spanish * primary diagnosis for admission is ssti, including cellulitis, abscess, fasciitis, myositis * requiring admission to an inpatient service exclusion criteria: * patients in custody of law enforcement * patients on a psychiatric hold

Keywords: skin soft tissue infection cellulitis abscess
care path for the management of ulcerative colitis

Conditions: Ulcerative Colitis

Summary: assess if standardized care-path that features objective evaluations of disease activity and time-bound algorithms is superior to usual step-care in the treatment of ulcerative colitis.

step-care based on symptomatic response remains the overwhelming algorithm of choice in clinical practice. many subjects receive infliximab only as a last resort, when the subject is very ill and has failed repeated attempts of corticosteroid induction therapy. although this situation is far from ideal, to change such entrenched physician behavior will require compelling evidence that step-care results in inferior outcomes to earlier introduction of effective therapy. based on these considerations, we will perform a cluster randomization trial in which 40 gastroenterology practices will be randomly assigned to a treatment algorithm featuring the early use of combination therapy, treatment intensification guided by objective assessments of inflammation and the use of remission as a therapeutic goal or a conventional step-care approach.

Eligibility criteria:
inclusion criteria: * females of child bearing potential must have a negative serum pregnancy test prior to randomization, and must use a hormonal (oral, implantable or injectable) or barrier method of birth control throughout the study. females unable to bear children must have documentation of such in the source records -- - documented diagnosis of uc with a mayo clinic score (mcs) ≥6 and a baseline mayo endoscopy score \>2. * either an elevated serum c-reactive protein (crp) (above the upper level of normal (uln) according to local laboratory results) or elevated fecal calprotectin (\> 250 mg/kg) concentration. * requires sigmoidoscopic evaluation at baseline (standard of care) * written informed consent must be obtained and documented. * ability of subject to participate fully in all aspects of this clinical trial in the opinion of the investigator. exclusion criteria: * previous failure of tnf antagonist therapy * received any investigational drug in the past 30 days or 5 half-lives, whichever is longer. * pregnant or lactating women. * any conditions (e.g., history of alcohol or substance abuse) which in the opinion of the investigator, may interfere with the subject's ability to comply with study procedures.

Keywords: construct cluster randomization controlled trial gastroenterology practices in north america
effectiveness of point-of-care lung ultrasound for the management of childhood lower respiratory infections

Conditions: Lower Respiratory Infection; LRTI; Pneumonia; Bronchiolitis

Summary: the goal of this clinical trial is to evaluate the effectiveness of point-of-care lung ultrasound versus chest x-ray for the management of childhood lower respiratory infections in a low-resource setting. the main question it aims to answer is: is point-of-care lung ultrasound as effective as chest x-ray for the management of childhood lris in a low-resource setting? participants will be assigned to either a point-of-care lung ultrasound group (intervention) or a chest x-ray group (control), to compare the effect on overall case management and various clinical outcomes (time to symptom resolution, rate of antibiotic use, length of stay, treatment costs).

background: lower respiratory infections (lris) are the leading causes of mortality in children of low-middle income countries (lmics) including nepal; pneumonia being the major killer in under-5 population. often, the cause of mortality is the delay in diagnosis and treatment, particularly when clinical assessments do not hint toward a diagnosis. in resource-limited settings, routine availability of chest x-ray (cxr) service is a challenge, it can be hazardous to children due to exposure to ionizing radiation. the point-of-care lung ultrasound (poclus) could be an alternative solution for the diagnosis and management of lris. studies have already shown that lung ultrasound has a higher sensitivity and specificity than cxr in diagnosing childhood lris, however, none of the studies have yet evaluated its role in overall case management. methods: prospective, single-center, pragmatic, open-label, randomized, controlled, non-inferiority clinical trial, which will be conducted in the outpatient and emergency departments of a pediatric hospital in nepal. a total of 616 children with clinical suspicion of lri and requiring chest imaging will be randomized at 1:1 allocation to the intervention (poclus) and control (cxr) arms. pediatricians will be trained to perform lung ultrasonography in children. outcomes: primary outcome is the proportion of 'correctly (effectively) managed' cases. secondary outcomes include the proportion of cases with 'change in diagnosis and management plan due to intervention', time to symptom resolution, rate of antibiotic use, length of stay, and in-hospital costs, compared between intervention and control groups.

Eligibility criteria:
inclusion criteria: * children with a suspected lower respiratory infection (lri) brought to the outpatient or emergency department, * requiring chest image for evaluation at baseline. exclusion criteria: * children already hospitalized, received antibiotics, or had chest imaging at the hospital; * follow-up (treated within the past 4 weeks) or referred cases; * critical patients requiring emergency life-saving support including oxygen; * children with one or more danger signs (lethargy or loss of consciousness, convulsion, unable to eat or vomiting everything, cyanosis, excess irritability)

Keywords: point-of-care lung ultrasound poclus lung pocus