Kornimate/medical-research-clean huggingface dataset:
hypothalamic-pituitary dysfunction in diabetes

Conditions: Diabete Mellitus; Hypogonadism; Hypogonadotropic Hypogonadism; Hypergonadotropic Hypogonadism; Central Hypothyroidism

Summary: type 2 diabetes mellitus (t2dm) is a chronic disease with a high prevalence and several comorbidities impacting on public health and society. among the complications of t2dm it has been showed a high prevalence of hypogonadotropic hypogonadism. even if hypogonadism is associated to a worse metabolic profile and cardiovascular risk, it is discussed whether and when to treat this potentially reversible form associated to diabetes. in fact, the pathogenic mechanism of this condition in diabetic patients is not fully understood, and its clinical correlates, including the prevalence of other possible associated hypothalamic-pituitary axes dysfunctioning, questioned. the aim of the present study is to assess with an observational, cross sectional study on a large series of type 2 diabetic patients, enrolled consecutively: all the suspected etiologies of this complication in one single evaluation (both acquired and genetic congenital predisposition), its clinical correlates and the real prevalence of the disease using the lastly validated criteria for late onset hypogonadotropic hypogonadism.


Eligibility criteria:
inclusion criteria: * age between 18 and 80 years old * males * proved diagnosis of t2dm exclusion criteria: * patients affected with known hypothalamic-pituitary diseases at the enrollment. * patients affected with severe systemic diseases, fever, chronic inflammatory disorders with pcr \> 10 mg/dl * malnutrition with bmi \<17 kg/m2 * use of glucocorticoids at the enrollment * poor understanding of spoken and written italian * patients affected with known primary diseases of the testes at the enrollment
therapeutic effects of liver failure patients caused by chronic hepatitis b after autologous mscs transplantation

Conditions: Liver Failure; Mesenchymal Stem Cells

Summary: the study aimed to investigate the short-term efficacy and long-term prognosis of liver failure patients caused by hepatitis b after single transplantation with autologous marrow mesenchymal stem cells (mmscs). liver failure inpatients caused by hepatitis b were recruited and received the same medical treatments, among whom some patients underwent single transplantation with autologous mmscs and other patients with matched age, gender and biochemical indexes \[alanine aminotransferase (alt), albumin (alb), total bilirubin (tbil), prothrombin time (pt) and model for end-stage liver disease (meld) \] were in control group. a total of 120 ml bone marrow were obtained from patients, diluted and separated. then mmscs suspension were slowly transfused into the liver through the proper hepatic artery by interventional procedures. the levels of alb, tbil, pt and meld score of patients in translation group were compared with those in control group. in 3 \~ 48 months of follow-up, differences in long-term outcomes such as incidence of hcc (hepatocellular carcinoma) and mortality between two groups were compared.

a total of 527 patients with chronic hepatitis b induced liver failure were recruited from may 2005 to june 2009 from our department. the diagnoses of chronic hepatitis b and liver failure were based on previously described criteria. all patients received the same medical treatments (reducibility glutathione, glycyrrhizin, ademetionine, polyene phosphatidylcholine, alprostadil, and human serum albumin). informed consent was obtained before study. among these patients, 53 received transplantation with autologous mmscs. the day of surgery served as the first day of observation. and 105 patients with matched age, gender and some biochemical indexes (alt, alb, tbil, pt and meld ) were served as controls.

Eligibility criteria:
inclusion criteria: * liver failure exclusion criteria: * hbv negative

Keywords: short-term effects long-term follow-up liver failure patients autologous mscs transplantation
comparison of 1 vs 3 sets of resistance training on muscular hypertrophy

Conditions: Obesity

Summary: this study is designed to investigate the effects of two levels of resistance weight training on body composition, energy expenditure, and energy intake in men and women. the weight training will take about one hour to complete. participants will perform the training 3 days per week for 9 months in a private exercise room equipped with state of the art equipment and a personal trainer to help guide you through the exercises. the project lasts 21 months total with one follow-up visit 1-year from your last training date. you will be required to stay in the lawrence area and train 3 day/week over the summer \& holidays.

we propose to conduct a randomized controlled efficacy trial (rt-1 set vs. rt-3 sets vs. non exercise control) to evaluate the potential for a longer intervention (9 months rt with body composition assessments 1 yr post rt completion) with a higher volume of rt (3 sets) to enhance the effects on body composition and energy expenditure observed in the pilot, and to determine the impact of the 2 levels of rt on free-living energy balance (expenditure by doubly labeled water and intake by digital photography and 24-hr recalls). this investigation will be conducted in a sample of healthy, normal and overweight, sedentary, young adult men and women; a group at high risk for development of overweight and obesity. the specific aims of this project are to determine the impact of the volume (1 vs. 3 sets) of a progressive rt protocol for inducing muscular hypertrophy, as recommended by the american college of sports medicine, on body weight and body composition (fat mass, fat-free mass (ffm), % body fat) and energy balance. our results will provide information relative to the minimum volume of rt that may be associated with body weight/fat gain which may inform the development of guidelines for rt to prevent weight gain or to alter body composition. if rt has a favorable impact on energy balance and body composition, it may provide an attractive alternative to aerobic exercise for weight management for busy young adults, as rt requires minimal time, and no need to change clothes or shower (i.e. minimal or no sweating).

Eligibility criteria:
inclusion criteria: * bmi 22-\<30 * 18- 30 years old * sedentary * no medications * weight stable for at least 3 months exclusion criteria: * tobacco/drug user * metabolism altering medication * gain/lost 10lbs in the last 3 months * current exerciser

Keywords: resistance and weight loss training
comparison of intramuscular olanzapine depot to oral olanzapine and low-dose depot in patients with schizophrenia

Conditions: Schizophrenic Disorders

Summary: this is a randomized, double-blind study to determine how well intramuscular (im) olanzapine depot works compared to oral olanzapine; evaluate the safety and tolerability of im olanzapine depot compared to oral olanzapine; evaluate different doses of im olanzapine depot; and determine the blood levels of im olanzapine depot in patients at different points in time after an injection.


Eligibility criteria:
inclusion criteria: * patients must have schizophrenia * patients must be clinically stable on antipsychotic medication * patients must be retrospectively judged by investigators, based on clinical interview and impression, to have been stable (with respect to their symptoms of schizophrenia) for at least 4 weeks entry into the study * patients must be an outpatient and have bprs positive items scores of 4 or less to enter the study * female patients of childbearing potential must be using a medically accepted means of contraception. exclusion criteria: * patients must not have participated in a clinical trial of another investigational drug, including olanzapine, within 1 month (30 days) prior to study entry. * female patients must not be pregnant or breast-feeding * patients must not be experiencing acute, serious, or unstable medical conditions other than schizophrenia * patients must not require concomitant treatment with any other medication with primarily central nervous system activity, including antidepressants, mood stabilizers, and anticonvulsants. * patients must not have a substance (except nicotine or caffeine) dependence within the past 30 days
mentalization-based group therapy for adolescents

Conditions: Deliberate Self-Harm

Summary: this is a prospective parallel group design of group-based mentalization-based therapy for adolescents (mbt-a) through a pilot randomised controlled trial comparing group-based mbt-a plus treatment as usual (tau) to tau alone. as a pilot study, we aim to determine: the effectiveness of our recruitment strategies; compliance with protocol/procedures; trends towards reduced self-harm.


Eligibility criteria:
inclusion criteria: * self-harm behaviour in the past 6 months * in receipt of treatment from local child and adolescent mental health services * competent and willing to provide written, informed consent. exclusion criteria: * severe learning disability or pervasive developmental disorder * acute psychotic episode * eating disorder in the absence of self-harm. * non-english speaking * current involvement in other ongoing treatment research

Keywords: adolescent
developing viability index for machine perfused livers

Conditions: Liver Cirrhoses

Summary: machine perfusion technology is nearing the point of rescuing discarded liver grafts in the hope of proving them to be or improving them to the point of being transplantable. however, there are no validated metrics to determine transplantability after machine perfusion. this study involves collecting biopsies from transplanted livers before and after implantation to correlate metabolite and gene expression with post-transplant function. this data will help develop a viability index for machine perfused livers.


Eligibility criteria:
inclusion criteria: * male or female 18-75 years of age. * candidate for a deceased-donor liver allograft. exclusion criteria: * seropositivity for hiv-1.
improving swallowing after stroke with transcranial direct current stimulation

Conditions: Acute Stroke; Dysphagia

Summary: in the acute phase of stroke, dysphagia (difficulty/inability to swallow) is a common problem that can have serious consequences such as aspiration pneumonia, increased lenght of hospitalisation, and death. it would be interesting to enhance the therapeutic effect of swallowing retraining by means on non-invasive brain stimulation such as transcranial direct current stimulation (tdcs). hypothesis: during the acute phase of stroke, applying tdcs over the brain during the revalidation and/or supervised feeding improves dysphagia significantly when compared to sham tdcs.

tdcs will be used in a double-blind, randomized control trial in acute stroke patients suffering from dysphagia. after informed consent and recruitment, patients will be randomly (computer method) allocated to real or sham tdcs, that will be applied during swallowing exercices/therapy or supervised feeding. baseline and follow-up outcomes about dysphagia will be collected.

Eligibility criteria:
inclusion criteria: - acute stroke (ischemic / hemorrhagic) with dysphagia exclusion criteria: * major swallowing impairment before the stroke * troubles of comprehension impairing communication * major cognitive dysfunction, neuro-degenerative disease, or major psychiatric condition (e.g. depression, alzheimer's disease, ...) * very unstable health issue (e.g. severe cardiac dyscfct, end-stage renal failure, unstable diabetes, ...) * intracranial metal and/or devices excluding tdcs application * chronic intake of major drugs modifying brain activity (e.g. aeds, antipsychotics) * regular use of alcohol or recreative drugs * epilepsy * pregnancy
enhancing diagnostic accuracy in fracture identification on musculoskeletal radiographs using deep learning

Conditions: Fractures; Musculoskeletal

Summary: this retrospective study aims to evaluate the effectiveness of artificial intelligence (ai) in identifying fractures on musculoskeletal x-rays. by comparing the performance of a deep learning ai model with that of experienced radiologists, we seek to understand how ai can help improve fracture detection accuracy in clinical settings. the study analyzed 600 x-rays from both pediatric and adult patients, focusing on identifying fractures across different body parts, including the foot, ankle, knee, hand, wrist, and more. the findings show that integrating ai can increase radiologists' sensitivity in detecting fractures, potentially improving patient outcomes by reducing the number of missed injuries.


Eligibility criteria:
inclusion criteria: * patients aged 1 year or older. * musculoskeletal x-rays available in digital imaging and communications in medicine (dicom) format. * at least one digital plain radiograph of an appendicular body part, including the foot, ankle, knee, hand, wrist, elbow, shoulder, or pelvis. exclusion criteria: * poor radiographic quality that precludes human interpretation. * radiographs of the lumbar, thoracic, and cervical spine, or facial/nasal bones. * radiographs that do not meet the inclusion criteria for appendicular body parts.
image-guided pleural biopsy or medical thoracosocopy in diagnosis of pleural disease

Conditions: Diagnosis of Pleural Diseases

Summary: pleural diseases can occur due to numerous pathological conditions. the increasing prevalence of etiologic causes and aging population worldwide will make pleural diseases a growing problem in the coming years. as a result of this increase, the need for diagnostic investigations is also increasing. in recent years, the use of image-guided needle biopsies under ultrasound (us) or computed tomography (ct) and the increasing use of medical thoracoscopy (mt) have significantly increased the accuracy of diagnosis of pleural disease. there is not yet a generally accepted algorithm for invasive diagnosis of pleural disease, widely used in clinics, that determines which method should be used in which patient. it would be necessary and valuable to develop an algorithm based on imaging findings in particular to improve the diagnostic accuracy, safety, and cost of the procedure. the investigators aimed to test the algorithm in an interventional study to increase the level of evidence in this study.

no consensus exists regarding which biopsy methods are appropriate for specific procedures. in this randomized prospective study, the investigators aimed to compare image guided - pleural biopsy using an abrams' needle (ig-anpb) with medical thoracoscopy (mt) according to the ct findings of the patients concerning both diagnostic yield and safety. between may 2017 and march 2022, 228 patients with exudative pleural effusion who the cytological analysis could not diagnose were included. all patients were separated into two groups regarding the ct findings: only pleural effusion or pleural effusion with pleural thickening/lesion. in each group, the patients were randomized to either underwent ig-anpb or underwent mt. the two groups were compared in terms of diagnostic sensitivity, accuracy, and complications.

Eligibility criteria:
inclusion criteria: pleural effusion malignant pleural diseases pleurisy tuberculosis benign pleural diseases exclusion criteria: age less than 18 years, parapneumonic effusion, presence of other systemic diseases that could interfere radiological evaluation.

Keywords: pleura thoracoscopy pleural needle biopsy diagnosis
the effect of needle-free injection system during palatal anesthesia

Conditions: Pediatric Anesthesia; Local Anesthesia

Summary: needle-free injection systems can contribute to the prevention of needle-related pain during palatal infiltration anesthesia (pia) in children. research with this topic on children is required.the purpose of this clinical study was to evaluate the effectiveness of the needle-free system versus traditional anesthesia on pain perception during pia in children.the study was designed as a randomized, controlled cross-over clinical study with 48 children aged 6 to 12 years requiring dental treatment with pia in bilateral maxillary primary molars. it has been revealed that the application of a needle-free system during pia ensured a decrease in pain perception in children.


Eligibility criteria:
inclusion criteria: * in need of treatment of right and left primary molar teeth of maxilla, * does not have any systemic disorder, * high level of communication that can provide logical answers to the questions we ask * with parental consent, * volunteers who want to participate in the research * 6-12 years old patients who are compatible with routine dental treatments in the pediatric clinic exclusion criteria: * no need for treatment of right and left primary molar teeth of maxilla, * has a systemic condition * low level of communication that cannot provide reasonable answers to the questions we ask * without parental consent * do not want to participate voluntarily in the research * do not attend a check-in * patients not in the 6-12 age group

Keywords: needle-free injection system pain perception
randomized trial of prolonged exposure for the treatment of posttraumatic stress disorder (ptsd)

Conditions: Posttraumatic Stress Disorder

Summary: this project will examine the impact of pe therapy for the treatment of ptsd with a sample of latinos. the need to provide effective treatment to spanish-speaking latinos with ptsd is critical given the high prevalence of ptsd among latinos. furthermore, ptsd remains an under detected and under treated condition. untreated ptsd has a substantial impact on health, functioning and quality of life. pe is one of the most empirically supported psychological interventions for ptsd. however, most studies that evidence the efficacy of pe have been conducted mainly with english-speaking caucasian populations. this study has the potential to contribute to improvements in the well-being of spanish-speaking latinos with ptsd.


Eligibility criteria:
inclusion criteria: * 18 to \< 65 years * meet diagnostic criteria for ptsd * spanish speaker * allow recording of assessments and therapy exclusion criteria: * significant current suicidal or homicidal ideation * history of bipolar, schizophrenia or psychotic disorder * alcohol or drug abuse during the past three months * current high risk of being assaulted (i.e., living with domestic violence) * current psychotherapy to treat ptsd * unable to provide informed consent

Keywords: posttraumatic stress disorder (ptsd) prolonged exposure (pe)
phase ⅳ clinical trial to evaluate of renamezin in patients with chronic renal failure.

Conditions: Chronic Renal Failure

Summary: renamezin capsule (an oral adsorbent) lowers indoxyl sulfate levels in patient with chronic renal failure. 120 patients with chronic renal failure(baseline serum creatinine:1.5-5.0mg/dl). renamezin is administered 6.0mg/day. the treatment period is 2 months. the change in serum indoxyl sulfate will be evaluated.


Eligibility criteria:
inclusion criteria: 1. patients spontaneously written consent to participate in this clinical trial 2. men and women over age of 19 3. pre-dialysis patients with chronic renal failure stage patient for 3 months and patients for holding the stable state in serum creatinine 1.5mg/dl - 5.0mg/dl 4. patients who were no noticeable change for 12weeks before screening and are expected to change is not needed during therapy in the therapy of chronic renal failure(medication and dose -related, diet therapy) exclusion criteria: 1. patients with passes through the digestive tract disorders 2. patients with uncontrolled constipation symptoms 3. patients suffering from digestive tract ulcers and esophageal varices 4. patients with untreated severe hypertension (dbp ≥ 120mmhg) 5. patients hospitalized with angina pectoris, cardiovascular disease or diagnosed with serious arrhythmia or cerebrovascular disease within 6 months 6. patients with hepatic impairment (2 times greater than the upper limit of normal levels of ast, alt) 7. subjects with dependency on alcohol 8. patients with current infections 9. pregnant women, nursing mothers 10. patients with a possibility of pregnancy (however, negative case can be registered) 11. patients participating in another clinical trial in addition to the current clinical trial 12. patient who do not fit the clinical trial participation the legal and mentally
identification of immunomodulators associated with atrial fibrillation reporting: analysis of the who pharmacovigilance database

Conditions: Atrial Fibrillation

Summary: atrial fibrillation is the most prevalent sustained arrhythmia worldwide with a great morbimortality. some populations are more at risk to develop atrial fibrillation like patients suffering from inflammatory diseases or patients suffering from cancers. this is at least explained by the inflammatory environment related to these both conditions. many experimental studies and clinical studies support the role of inflammation and immunity in atrial fibrillation genesis by modulating atrial action potential et by promoting fibrosis. immunomodulators are drugs used to stimulate or inhibit the immune system for two main indications : cancers and immune disorder diseases which both promote atrial fibrillation. due to their interactions with inflammation and immunity, immunomodulatores may further promote the risk of atrial fibrillation, particularly in a population already at risk. based on the world health organization global database, the main objective of this study is to investigate the association between immunomodulators and the occurrence of atrial fibrillation reported in the database. a disproportionality analysis will be performed. it will aim to assess whether immunomodulators are associated with a greater risk of atrial fibrillation. secondary objectives aim to describe the cases of atrial fibrillation among immunomodulators associated with atrial fibrillation in the main analysis, to describe coprescription among immunomodulators associated with atrial fibrillation in the main analysis, to analyse the role of immunomoduloators medical indication in the overrisk of atrial fibrillation, and to try to highlight some immune mechanisms promoting atrial fibrillation regarding the immunomodulators associated with atrial fibrillation in the main analysis.


Eligibility criteria:
inclusion criteria: * case reported in the world health organization (who) database of individual safety case reports to 01/09/2022 * patients treated with fda approved immunomodulators (approval the 1st january 2023).

Keywords: immunomodulators pharmacovigilance atrial fibrillation