Kornimate/medical-research-clean huggingface dataset:
a study comparing two fluticasone furoate nasal sprays in the relief of the signs and symptoms of seasonal allergic rhinitis

Conditions: Rhinitis, Allergic, Seasonal

Summary: this study compared the safety and efficacy of a generic fluticasone furoate (lek pharmaceuticals) nasal spray to the reference listed drug in the treatment of seasonal allergic rhinitis. additionally both the test and the reference formulations were tested for superiority against a placebo nasal spray.

the study was designed as a double-blind, randomized, placebo-controlled, parallel group, multi-site to compare the clinical equivalence of the test formulation of fluticasone furoate, 27.5 mcg/actuation nasal spray (lek pharmaceuticals d.d.) with the reference formulation veramyst® nasal spray (glaxosmithkline) in the relief of the signs and symptoms of seasonal allergic rhinitis. participants who met the inclusion/exclusion criteria entered a 7-day placebo lead-in period. following this placebo lead-in period, on day 1 participants who continued to meet eligibility criteria were randomly assigned in a 2:2:1 ratio to one of three treatment groups (test product:reference product:placebo) for 14 days of treatment. in all treatment groups, participants were instructed to administer the study drug once daily at approximately the same time each day. a single dose of 110 mcg was 4 actuations, each containing 27.5 mcg per actuation. patients were instructed to administer the 4 actuations alternating between right and left nostril, such that 2 actuations were not administered back to back to the same nostril.

Eligibility criteria:
inclusion criteria: * male or non-pregnant, non-lactating female 12 years of age or older with a minimum of 2 years of previous history of seasonal allergic rhinitis to the pollen/allergen in season at the time the study is being conducted. * signed informed consent (assent) form. * documented positive allergic skin test to local pollen. * an average score of at least 6 on the reflective total nasal symptom score (rtnss) with a minimum score of at least 2 for "nasal congestion" and at least 4 on the reflective total ocular symptom score (rtoss). exclusion criteria: * history of asthma that required chronic therapy (with the exception of occasional acute or mild exercise induced asthma). * some other past and concomitant medical conditions, prohibited medications. * upper respiratory tract infection or any untreated infections. * patient has started immunotherapy/changed the dose. * any known allergy to any of the components of the study nasal spray.

Keywords: rhinitis seasonal allergic rhinitis fluticasone furoate equivalence hay fever
impact of vitamin a on rar gene expression in multiple sclerosis

Conditions: Relapsing Remitting Multiple Sclerosis

Summary: the aim of this study is the comparison between the effects of supplementation with 25000 iu preformed vitamin a (retinyl palmitate)on retinoic acid receptor and retinoic x receptor expression.

multiple sclerosis (ms) is a chronic inflammatory disease where th1 like responses from myelin-specific cd4+ t cells, as secretion of pro-inflammatory ifnγ, are believed to play a major role in the pathogenesis. the myelin-specific t cells that mediate tissue destruction in ms are believed to become activated outside the central nervous system (cns) in lymphoid tissue and when they cross the blood brain barrier they will re-encounter their antigen. immune deviation is the redirection of the immune response from most often th1 like responses to th2 like responses, even though the opposite can also occur. vitamin a or vitamin a-like analogs known as retinoids, are potent hormonal modifiers of type 1 or type 2 responses but a definitive description of their mechanism(s) of action is lacking. high level dietary vitamin a enhances th2 cytokine production and iga responses, and is likely to decrease th1 cytokine production. retinoic acid(ra) inhibits il12 production in activated macrophages, and ra pretreatment of macrophages reduces ifnγ production and increases il4 production in antigen primed cd4 t cells. supplemental treatment with vitamin a or ra decreases ifnγ and increases il5, il10, and il4 production by increase of retinoic acid receptor and retinoic x receptor . record verification date: august 2011

Eligibility criteria:
inclusion criteria: * patients who have used interferon beta in last 3 months. * patients with 0-5 edss exclusion criteria: * patients who have diseases which affect on th1/th2 balance such as asthma, active viral infections, and autoimmune diseases, or * patients who have allergy to vitamin a compounds, or * patients who have used vitamin supplements in last 3 months.

Keywords: multiple sclerosis vitamin a retinoic acid receptor retinoic x receptor
magnesium sulphate and extubation quality

Conditions: Perioperative Complication

Summary: the investigators aimed to search effect of magnesium sulfate on extubation quality scores, recovery and pain in larynx micro surgery. the patients allocated to two groups to receive magnesium sulfate 30 mg/kg in 100 ml saline infusion (maximum 2g) (group m) or saline 100 ml (group s) before induction of anesthesia. anesthesia induction performed with propofol 2 mg/kg, rocuronium 0.6 mg/kg, remifentanil 0.5 µg/kg and general anesthesia maintained with total intravenous anesthesia (propofol 3-7 mg/kg, remifentanil 0.05-0.1 µg/kg/min and o2/air 30/70 mixture) to the all patients. extubation quality scores, extubation time, nrs scores were assessed.

the investigators aimed to search effect of magnesium sulfate on extubation quality, recovery feature and complications.98 adult patients scheduled for larynx laser microsurgery were included and randomly allocated to two groups to receive magnesium sulfate 30 mg/kg in 100 ml saline infusion (maximum 2g) (group m) or saline 100 ml (group s) before induction of anesthesia. anesthesia induction performed with propofol 2 mg/kg, rocuronium 0.6 mg/kg, remifentanil 0.5 µg/kg and general anesthesia maintained with total intravenous anesthesia (propofol 3-7 mg/kg, remifentanil 0.05-0.1 µg/kg/min and o2/air 30/70 mixture) to the all patients. paracetamol 15 mg/kg applied to all patients.extubation quality score, extubation time, stay in postanesthesia unit (pacu) time, numeric rating scale (nrs) and complications were recorded.

Eligibility criteria:
inclusion criteria: * 18 age over * american society of anesthesiology (asa) clinical status i-iii * the patients who experience larynx micro surgery exclusion criteria: * under 18 years old * asa iv and over * severe airway obstruction * neuromuscular disease * presence of tracheostomy
study of biomarkers using tissue samples from older patients with diffuse large b-cell lymphoma treated with combination chemotherapy with or without rituximab on clinical trial ecog-e4494

Conditions: Lymphoma

Summary: rationale: studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. it may also help doctors understand how patients respond to treatment. purpose: this laboratory study is looking at biomarkers using tissue samples from older patients with diffuse large b-cell lymphoma treated with combination chemotherapy with or without rituximab on clinical trial ecog-e4494.

objectives: * to construct tissue microarrays (tma) using tissue samples from older patients with diffuse large b-cell lymphoma treated with standard chop chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab on clinical trial ecog-e4494. * to allow this tma resource to be included in a large international effort (the lunenburg lymphoma biomarker consortium \[llbc\]), partnering with several other similar randomized trials (eortc, hovon, gela, mint) in order to properly power and bring standardization to the study of biomarkers in lymphoma. * to evaluate the clinical impact and prognostic importance of a number of biomarkers, including bcl-2, bcl-6, cd10, foxp1, mum1, ki-67, cd5, and hla-dr. * to determine the prognostic impact of clinical international prognostic index (ipi) variables in a large international study. * to determine the relationship between different biomarkers and clinical predictors. * to establish the tma (using tissue samples from patients treated on clinical trial ecog-e4494) as a resource for future ecog-driven studies and for validation of novel biomarkers as they become recognized and available. outline: patients are stratified according to prior treatment (chop chemotherapy \[cyclophosphamide, doxorubicin, vincristine, and prednisone\] or chop-like chemotherapy vs chop chemotherapy with or without rituximab). tissue microarrays will be constructed using tissue samples previously collected from patients treated on clinical trial ecog-e4494. tissue microarrays will be used for biomarker studies.

Eligibility criteria:
disease characteristics: * diagnosis of diffuse large b-cell lymphoma * received treatment on clinical trial ecog-e4494 patient characteristics: * not specified prior concurrent therapy: * not specified

Keywords: contiguous stage ii adult diffuse large cell lymphoma noncontiguous stage ii adult diffuse large cell lymphoma recurrent adult diffuse large cell lymphoma stage i adult diffuse large cell lymphoma stage iii adult diffuse large cell lymphoma stage iv adult diffuse large cell lymphoma
effects of vr-based respiratory training on motor reaction time and correctness, stress levels, attention, motor skills, postural stability and sleep quality in shift healthcare workers

Conditions: Healthcare Workers; Stress Level; Emergency Department; Shift Work Sleep Disorder; Postural Stability; VR Breathing Exercises; Attention; Time Reaction

Summary: this study investigates the effects of virtual reality (vr)-based respiratory training on various physiological and cognitive functions in shift-working healthcare professionals, including paramedics and nurses. the research will evaluate how vr-guided breathing exercises influence: stress levels, motor reaction time and accuracy, attention and cognitive performance, motor skills and postural stability, sleep quality participants will be divided into three groups: vr-based respiratory training group - performing guided breathing exercises in a vr environment. music-based relaxation group - listening to relaxing music without structured breathing instructions. control group - no intervention. the findings will help determine whether vr-based respiratory training is an effective method for improving stress resilience, cognitive function, and physical performance in shift-working healthcare professionals.


Eligibility criteria:
the study will be conducted in a group of paramedics and nurses of both sexes, aged 23-45. it is expected that 60 people will be examined. the study will include hospital emergency department employees, working shifts, with a minimum of two years of work experience. those who receive a doctor's consent to participate in the study and give informed consent will be admitted to the study.
the effect of two method to reducing pain and fear during draw blood from children

Conditions: Pain, Procedural; Pain Management; Child, Only

Summary: this study was conducted to evaluate the effects of two different distraction methods on reducing pain and fear during blood collection from children. the study was conducted between january 2020 and may 2021.

the study was a pretest-posttest, parallel group randomized controlled experimental design. h0: the pain and fear mean scores of the intervention group, in which the distraction method (ball squeezing and blowing bubbles) was applied during the blood collection process, was not different from the control group. the study was carried out with the participation of 111 children aged 6-12 years and their parents, who underwent blood collection in the emergency department of a state hospital. children were randomly assigned to blowing bubbles (n:37), ball squeezing (n:37) and control (n:37) groups. bubble blowing and ball squeezing methods were used to distract attention during the blood collection process. data were collected with child and family information form, wong baker faces pain scale, child fear scale. pretest and posttest measurements were recorded separately by the child, parent and researcher. descriptive statistics, chi-square test, one-way analysis of variance, tamhane's t2 test, t test for dependent groups were used in the analysis of the data. the statistical significance of the results was taken as p\<0,05

Eligibility criteria:
inclusion criteria: * being between the ages of 6-12 * the child's willingness to voluntarily participate in the study * parent's willingness to participate in the study voluntarily * parent and child can speak turkish exclusion criteria: * the child has a disease that causes chronic pain * the child has a hearing or visual impairment * the child has a mental or neurological disability * the child has used drugs that will create an analgesic effect in the last 24 hours before the application

Keywords: pain procedural fear child distraction methods
long term effects of a structured lifestyle program

Conditions: Lifestyle; Quality of Life

Summary: the aim of the present study was to describe a structured intervention to reduce cardiovascular risk in a clinical setting and to study the effects of the program on lifestyle habits and quality of life in individuals at risk after six months and one year.


Eligibility criteria:
inclusion criteria: (three risk factors ) * cardiovascular disease * physical inactivity * smoking * risk consumption of alcohol * unhealthy food habits * stress * overweight or abdominal obesity * high lipids (cholesterol, ldl) * high blood pressure * diabetes/insulin resistance. exclusion criteria: * not understand swedish language
glottic width and respiratory flow in patients with various lung diseases

Conditions: Lung Diseases

Summary: in this study the investigators examine the glottic width and the respiratory flow at rest in patients with various lung disease. the investigators postulated that a positive expiratory pressure is created through the narrowing of the glottic width in patients with hyperinflation.


Eligibility criteria:
inclusion criteria: * clinical indication for a bronchoscopy * minimum age of 18 years * signed informed consent exclusion criteria: * patients requiring mechanical ventilation during bronchoscopy * disease of the larynx * inability to breathe through the mouthpiece

Keywords: glottic movement emphysema copd vocal cord
cardiac-control affecting learning through mindfulness (calm)

Conditions: Age-related Cognitive Decline; Alzheimer Disease

Summary: some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. the current study is designed to investigate how daily mindfulness practice with heart rate biofeedback during breathing in a pattern that either increases or decreases heart rate oscillation affect attention and memory and blood biomarkers associated with alzheimer's disease.


Eligibility criteria:
inclusion criteria * fluent in english * black/african-american or white/european-american * aged between 50-70 years old * non-pregnant and non-menstruating (for at least the past year) * have normal or corrected-to-normal vision and hearing * have reliable access to wifi * have an email account that you check regularly * have a phone that receives text messages * agree to provide blood and urine samples at two campus visits * agree to devote up to 50 minutes daily to this study for 10 weeks as well as attend two campus visits exclusion criteria * have a disorder that would impede performing the breathing intervention (e.g., abnormal cardiac rhythm, arrhythmia, dyspnea) * have cognitive impairment * have regularly played lumosity games in the past 6 months * have any conditions listed below that are not safe for mri * \*metal in any parts of your body * claustrophobia * have worked as a machinist, metal worker, or in any profession or hobby grinding metal? * have had an injury to the eye involving a metallic object (e.g., metallic slivers, shavings, or foreign body) * cardiac pacemaker * implanted cardiac defibrillator * aneurysm clip or brain clip * carotid artery vascular clamp * neurostimulator * insulin or infusion pump * spinal fusion stimulator * cochlear, otologic, ear tubes or ear implant * prosthesis (eye/orbital, penile, etc.) * implant held in place by a magnet * heart valve prosthesis * artificial limb or joint * other implants in body or head * electrodes (on body, head or brain) * intravascular stents, filters * shunt (spinal or intraventricular) * vascular access port or catheters * iud * transdermal delivery system or other types of foil patches (e.g., nitro, nicotine, birth control, etc.) that cannot be removed for mri * shrapnel, buckshot, or bullets * tattooed eyeliner or eyebrows * body piercing(s) that cannot be removed for mri * metal fragments (eye, head, ear, skin) * internal pacing wires * aortic clips * metal or wire mesh implants * wire sutures or surgical staples * harrington rods (spine) * bone/joint pin, screw, nail, wire, plate * wig or toupee that cannot be removed for mri * hair implants that involve staples or metal * hearing aid(s) that cannot be removed for mri * dentures or retainers that cannot be removed for mri
comparison of the bulb aspirator to a nasal oral aspirator in the treatment of bronchiolitis

Conditions: Bronchiolitis; Aspirator

Summary: the investigators aim to compare the standard bulb aspirator with that of a nasal oral aspirator. the hypothesis is that use of a nasal oral aspirator is more effective at removing nasal secretions in the treatment of bronchiolitis as measured by a predicted 50% decrease in the rate of unscheduled bronchiolitis return visits. the primary endpoint will be the number of unscheduled bronchiolitis return visits; secondary endpoints will include measurements of oral intake, respiratory relief, parental device preference and adverse events.

this study will be a single center, single blind, randomized controlled trial in the pediatric emergency department (ed) at dell children's medical center of central texas (dcmc). an ed discharge diagnosis of bronchiolitis will trigger patients to be randomized to receive a bulb aspirator or nasal oral aspirator for home secretion management use. prior to dispensing the randomized aspirator, a pre-distribution questionnaire will be administered. additionally, patients will receive a diary to complete for 3 days post ed discharge. research personnel will call families on day 4 as a reminder to return the diary and again on day 14 to obtain a verbal post-study questionnaire. research personnel will perform chart review on all patients looking for unscheduled patient return visits for bronchiolitis.

Eligibility criteria:
inclusion criteria: * children \>28 days of life to \< 2 years of age discharged home from the dcmc ed with a diagnosis of bronchiolitis (diagnosis made per provider discretion) * caregiver fluent in english or spanish exclusion criteria: * previous enrollment * hospital admission * parental refusal to be randomized to an aspirator device (i.e., family prefers current device and does not wish to be randomized to a potentially different product) * current bacterial pneumonia * diagnosis of asthma * chronic lung disease * significant underlying cardiac disease * chronic neuromuscular disease

Keywords: naspira suctioning nasal suction device children
a study evaluating the long-term safety and efficacy of vx-121 combination therapy

Conditions: Cystic Fibrosis

Summary: the purpose of this study is to evaluate the long-term safety, tolerability, and efficacy of vx-121/tezacaftor/deutivacaftor (vx-121/tez/d-iva) in participants with cystic fibrosis.


Eligibility criteria:
key inclusion criteria: * part a: completed study drug treatment in a parent study vx20-121-102 (nct05033080) and vx20-121-103 (nct05076149); or had study drug interruption(s) in a parent study but did not permanently discontinue study drug, and completed study visits up to the last scheduled visit of the treatment period in the parent study * part b: completed study drug treatment in part a; or had study drug interruption(s) in part a, but did not permanently discontinue study drug, and completed study visits up to the last scheduled visit of the treatment period of part a key exclusion criteria: * history of drug intolerance in a parent study * pregnant or breast-feeding females at the time of enrollment in part a other protocol defined inclusion/exclusion criteria may apply.
acute effects of hiit and ssmit on intraocular pressure among sedentary individuals

Conditions: Intraocular Pressure

Summary: purpose to study the acute effects of both forms of aerobic exercise (hiit and ssmit) on intraocular pressure among healthy sedentary individuals

40 participants were recruited and divided into 2 groups. each group performed 2 exercise protocols with a 4 day washout period between them. the intraocular pressure was measured before the exercise and after the exercise in 5 minute periods up until 30 minutes post exercise. the intraocular pressure was measured using a handheld rebound tonometer.

Eligibility criteria:
inclusion criteria: * all university hospital staff exclusion criteria: * previous ocular trauma * surgery in the eligible eye * known case of glaucoma or glaucoma suspect (iop \> 21mmhg) * history of glaucoma laser procedure/surgery within 6 months in eligible eye * unable to undergo iop measurements * undiagnosed visual condition * any uncontrolled medical condition such as end stage renal failure, uncontrolled diabetes and uncontrolled hypertension