Kornimate/medical-research-clean huggingface dataset:
effect of an antioxidant-rich diet during moderate altitude training

Conditions: Oxidative Stress; Adaptation Reaction; Inflammation

Summary: athletes, especially in endurance sports, are at increased risk of oxidative stress and inflammation-related diseases and injuries. the production of reactive oxygen and nitrogen species (rons) and inflammatory markers increase during exercise and especially during altitude training. antioxidant supplementation is commonly used among athletes in the belief that it prevents oxidative stress and oxidative damage. a transient increase of rons is however necessary to activate signaling cascades initiating training adaptation. antioxidant supplementation has been shown to inhibit the exercise effects in several independent studies, possibly by interfering/reducing the signal cascades initiated by rons. however, it is unknown whether a high intake of antioxidant rich foods can affect the amount of rons, inflammation markers and/or training adaptation. the investigators want to examine whether an increased intake of natural antioxidants in the form of antioxidant-rich foods fruits, vegetables and berries, in line with the official norwegian dietary advice can affect antioxidant status, immune function and training adaptation associated with altitude training in norwegian elite athletes.


Eligibility criteria:
inclusion criteria: * national team athletes, summer endurance sports exclusion criteria: * allergies in conflict with the intervention foods * use of medication that could affect training and performance * injuries that could affect training and performance

Keywords: altitude training antioxidants oxidative stress elite athletes inflammation diet
4 cities for assessing calcification prognostic impact after tavi

Conditions: Heart Disease

Summary: transcatheter aortic valve implantation (tavi) indications are progressing rapidly as an alternative to conventional surgery for aortic stenosis cure. despite a high rate of procedural success, some patients do not benefit from the procedure. the investigators hypothesis is that aortic stiffness may be of major prognostic significance after stenosis relief. the aim of this study is to test the prognostic impact of aortic stiffness estimated by the volume of calcifications of the thoracic aorta on the ct-scan performed systematically before the procedure. this prognostic value will be assessed in 4 independent cohorts issued from 4 french cities (lyon, rouen, paris, clermont-ferrand).


Eligibility criteria:
inclusion criteria: * age \> 18 * patient who underwent a transcatheter aortic valve implantation * patient who provided informed, written consent to participate to france tavi study * patient for whom a ct-scan performed before tavi procedure is available. exclusion criteria: * none

Keywords: tavi aortic stenosis aortic stiffness calcifications ct-scan vascular impedance
trial of paclitaxel/carboplatin + pf-3512676 vs paclitaxel/carboplatin alone in patients with advanced non-small cell lung cancer

Conditions: Carcinoma, Non-Small-Cell Lung

Summary: to assess the efficacy and safety of pf-3512676 administered in combination with paclitaxel/carboplatin chemotherapy as first-line treatment in patients with locally advanced or metastatic non-small-cell lung cancer (nsclc) and to compare it to the efficacy and safety of paclitaxel

pf-3512676 dosing was stopped 20 june 2007 in response to dsmc recommendation to close the trial, citing lack of efficacy concerns as the primary reason with a safety issue (sepsis) also contributing to the decision. subjects were allowed to complete standard of care treatment/survival follow-up. data collection was completed on 17 july 2008.

Eligibility criteria:
inclusion criteria: * advanced non-small-cell lung cancer (nsclc) stage iiib with pleural effusion or stage iv * no prior systemic treatment for non-small-cell lung cancer (nsclc)with chemotherapy, immunotherapy, biologic response modifiers or other investigational drugs * eastern cooperative oncology performance status (ecog ps) 0 or 1 exclusion criteria: * small cell or carcinoid lung cancer * known central nervous system (cns) metastasis * pre-existing auto-immune or antibody mediated diseases

Keywords: advanced carcinoma, non-small cell lung, phase iii, paclitaxel, taxol, carboplatin, paraplatin, pf-3512676, immunotherapy, immune modulator
impact of school based intervention on psychosocial factors associated with trauma among adolescents

Conditions: Interventional Study

Summary: the present study is designed to identifying the post-traumatic stress symptoms in children experiencing some traumatic event and to adapt and apply school based intervention (support for students exposed to trauma sset) to students who shows the symptoms of post-traumatic stress disorder.

childhood trauma is a major mental health problem in recent era. children who experienced sudden trauma have difficulty in learning, poor concentration in schools, and faced emotional and behavioral difficulties (holt, finkelhor, kantor, 2007). children who have been exposed to traumatic event are at a higher risk of developing psychopathology followed by trauma (alisic et al.,2014). the present study is designed to identifying the post-traumatic stress symptoms in children experiencing some traumatic event and to adapt and apply school based intervention (support for students exposed to trauma sset) to students who shows the symptoms of post-traumatic stress disorder. this school based intervention (sset) will provides a basis for how students can address overwhelming emotions, can deal with their daily life stressors and proactively learn to address unhelpful or maladaptive cognitions in positive way. this study will help to aware parents and teachers about mental health needs of children and adolescents.

Eligibility criteria:
inclusion criteria of the study is: * meets the cut off score on scale cats (child and adolescent trauma screen). * students availability for intervention phase * age range 10-16 years exclusion criteria: * students above 16 years and below 10 years will not be included in the study. * receiving any psychological/mental health services or taking antidepressants * students whose primary problem is child abuse .
psychosocial characteristics and non-pharmacological intervention of patients with treatment-resistant depression

Conditions: Treatment-resistant Depression

Summary: pharmacotherapy and psychotherapy, effective management strategies for treatment-resistant depression are limited and yet to be developed. however, nursing interventions focusing on adherence enhancement, symptom reduction, and stress management may be strategic for a better disease management. this study aimed to define the rarely-studied concept of trd under the cultural context of taiwan and to identify new feasible and complementary treatment model from nursing perspectives. the project had established important basis on the descriptions of psychosocial features and need assessment of people with trd over psychiatrist's validation. the findings also built up a cultural-specific non-pharmacological intervention module for effective trd management in taiwan. the nursing model of trd management will further promote the development of integrative depression care in the future and complement current modalities, while providing important evidence-based information for future research and services.

the three-year pioneering project began with observing the psychosocial characteristics and demographic profile of a group of trd cohort, followed by validating the cultural meanings and recovery constructs of trd through professional and lay focus groups in the first year. in the second to third year, we examined the effectiveness of a 8-week, nurse-led psychosocial intervention with group approach in a randomized control trial (rct) compared to the controls receiving usual care with three follow-ups. detailed psychiatric assessment and study interviews have been performed at baseline, 3, 6, and 9 months after the intervention by a senior psychiatrist and a research assistant using standardized operation forms.structured measurements have been utilized to collect primary outcome variables of psychological distress, suicide risk and resilience as well as secondary outcome measures of quality of life, community reintegration level, perceived satisfaction, and main clinical variables (e.g., treatment adherence, service use such as er/opd attendance or hospitalization days). the control group receives usual care of pharmacological therapy provided by the psychiatrists in the psychiatric department of the study hospital in northern taiwan.

Eligibility criteria:
inclusion criteria: 1. aged 20-85 ; 2. to be diagnosed with major depressive disorder or bipolar ii disorder; 3. failed to respond to at least three weeks of two antidepressant trials ; 4. able to communicate with mandarin or taiwanese ; 5. no severe or foreseeing cognitive impairment during study period judged by the co-pi； 6. willing to sign the informed consent. exclusion criteria: 1. unable to cooperate due to psychiatric symptom disturbance ; 2. unwilling to provide most information in the questionnaire ; 3. severely suicidal during study period

Keywords: psychosocial model,nursing intervention
the impact of free fatty acid reduction on vascular function in the metabolic syndrome

Conditions: Metabolic Syndrome

Summary: this study will test the hypothesis that reducing the release of free fatty acids (ffa) from fat cells will restore insulin-mediated, endothelium-dependent vasodilation in people with the metabolic syndrome.

we hypothesize that acipimox, by decreasing plasma ffa concentrations, will augment endothelium-dependent vasodilation in conduit vessels and insulin-mediated vasodilation in forearm resistance arterioles in vivo, whole-body insulin sensitivity, and akt (also known as protein kinase b) and endothelial nitric oxide synthase (enos) phosphorylation in skin biopsy specimens ex vivo, when compared with placebo.

Eligibility criteria:
inclusion criteria: * adults with metabolic syndrome, defined as the presence of 3 of 5 components of the syndrome as defined by the national cholesterol education program including: * abdominal obesity * elevated fasting blood sugar (110 mg/dl\< glucose \< 126 mg/dl) * low hdl * elevated fasting blood triglycerides (\> 150 mg/dl) * hypertension (bp \> 140/90 mm hg) * normal cardiovascular examination exclusion criteria: * diabetes mellitus * untreated hypercholesterolemia (ldl \> 75th percentile for age) * cigarette smoking within 1 year * renal insufficiency (creatinine \> 1.4 mg/dl) * blood dyscrasia * hepatic dysfunction (alt \> 2x normal) * evident coronary/peripheral atherosclerosis

Keywords: free fatty acids insulin-mediated endothelium-dependent vasodilation metabolic syndrome
fmri of vulnerable brain regions in persons at risk for alzheimer's disease

Conditions: Magnetic Resonance Imaging; Alzheimer's Disease; Dementia; Adult Children; Risk

Summary: the purpose of this study is to investigate the organization of memory and develop future methods for early detection of ad. using functional magnetic resonance imaging (fmri), we examine the responsiveness of the brain to memory tasks, specifically focusing on regions of the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved in early stages of alzheimer's disease (ad). of interest are differences in brain activation between people with and without a family history of ad and other risk factors.


Eligibility criteria:
inclusion criteria: * mci group: diagnosis of mild cognitive impairment * ad family history group: confirmed family history of alzheimer's and concurrent enrollment in the wisconsin registry for alzheimer's prevention (wrap) * control groups: cognitively healthy and both parents survived past age 70 with no memory problems exclusion criteria: * claustrophobia * metallic or electronic implants or devices that are not mri-safe
oxford classification and clinical remission after initial treatments in patients with iga nephropathy

Conditions: IgA Nephropathy

Summary: iga nephropathy (igan) is the most common form of primary glomerulonephritis and one of the leading causes of end-stage renal disease in china. the clinical manifestations of igan varies widely among individuals, and renal pathology is crucial for determining the severity of renal damage and predicting the renal progression. however, the association between renal pathology and patient response to medication has not been reported, and the majority of earlier rct studies have not taken renal pathology into consideration when enrolling patients. the kidney disease: improving global outcomes (kdigo) glomerular diseases work group, one of the most prestigious kidney disease organizations in the world, claims that there is not enough evidence to support the use of oxford classification to decide whether to administer immunosuppressive therapy to patients with igan.therefore, the goal of this study was to investigate the relationship between oxford classification and clinical remission rates following initial teatments in patients with igan, with the aim of providing a basis for individualized clinical treatment plans. this study was a single-center prospective cohort study, and patients who were hospitalized in shenzhen second people's hospital from january 2011 to january 2021 and diagnosed as igan by renal biopsy were collected continuously and followed up until december 2022. cox regression models were used to analyze the effect of different oxford classifications on the clinical remission rates of patients at 6, 12, 18, and 24 months of treatments, and the relationship between oxford classification and secondary outcome indicators such as long-term renal function and urinary protein changes were analyzed using generalized additive mixed models.


Eligibility criteria:
inclusion criteria: * age≥18 years； * initial renal biopsy； * glomeruli\>8； * egfr\>15ml/min； * proteinuria/creatinine ratio（pcr）\>0.5g/g exclusion criteria: * secondary igan * combined with other kidney diseases * combined with acute kidney injury * combined with tumor * followed-up time \<6 months

Keywords: iga nephropathy oxford classification clinical remission rate
topical 15% trichloroacetic acid versus silver nitrate cauterization in the management of idiopathic childhood epistaxis: a prospective double-blinded, randomized clinical trial

Conditions: Anterior Epistaxis

Summary: the invistigators aim to explore the efficacy of trichloroacetic acid as a chemical cauterization agent and compare it with that of silver nitrate in the treatment of idiopathic epistaxis in children.

epistaxis is a very distressing complaint in otorhinolaryngology that affects nearly 10-12% of the population worldwide . epistaxis in children is even more common. approximately half of the children had one or more episodes of epistaxis by the age of 10 . the source of epistaxis may be anterior or posterior; in children, epistaxis is commonly anterior, originating mainly from the anterior part of the nasal septum called little's area, in which a confluence of veins named kiesselbach's plexus is the main area to blame . anterior epistaxis is commonly related to local trauma, such as nose picking or crust formation, or local inflammation, such as upper airway infection and vestibulitis, due to bacterial inhabitants that lead to crusting and precipitation of epistaxis episodes. in the literature, there are various modalities for the treatment of anterior epistaxis, such as nose pinching and anterior nasal packing in emergent cases and medical treatment in between attacks, which are considered first aid, and whenever they fail, we shift to alternative methods that are considered invasive but more effective . one of the currently utilized modalities that has been shown to be effective in the management of epistaxis is chemical cauterization of the prominent vessels in little's area . in 1932, little was the first to introduce the idea of using silver nitrate as a chemical cautery agent in the treatment of anterior epistaxis, which results in coagulation of bleeding vessels and tissue destruction . another option for chemical cauterization is trichloroacetic acid (tca), which causes protein denaturation . trichloroacetic acid is available, inexpensive, and easy to use as a chemical cautery solution. however, there is not yet adequate evidence in the literature for the use of tca in the treatment of epistaxis. therefore, the invistigators aimed to explore the efficacy of trichloroacetic acid as a chemical cauterization agent and compare it with that of silver nitrate in the treatment of idiopathic epistaxis in children.

Eligibility criteria:
inclusion criteria: * all patients aged between 4 and 16 years at least once weekly in the last 4 weeks with visible anterior bleeding sources either unilateral or bilateral from little's area were included in the study. exclusion criteria: * all patients with documented coagulopathy, those with sinonasal or nasopharyngeal masses, those with active rhinosinusitis or severe allergic rhinitis or severe septal deviation
rehabilitative training for older people with schizophrenia

Conditions: Schizophrenia

Summary: this study will evaluate the effectiveness of a rehabilitation program called functional adaptation skills training (fast) in treating older patients with schizophrenia.

people with schizophrenia often have problems functioning in everyday life. as people with schizophrenia get older, resources for effective health care and social services may become more limited. there is a need to develop effective rehabilitation programs that are sensitive to the special needs of older persons with schizophrenia. patients are randomly assigned to either 1 of 2 groups. the fast group will involve 24 sessions of group intervention designed to enhance daily functioning of older patients with schizophrenia. the placebo group will involve participation in a psychosocial support group for an equivalent amount of time. treatment is followed by 6 monthly maintenance sessions. patients will be assessed at 6, 12, and 18 months after the study start. assessments include clinical and functional measures.

Eligibility criteria:
inclusion criteria: * have schizophrenia or schizoaffective disorder
single-cell landscape of balf in patients with severe ards and cards

Conditions: ARDS: Acute Respiratory Distress Syndrome; Covid19

Summary: the goal of this observational study is to learn about the effect of steroid therapy in patients with covid-19 ards. the main questions it aims to answer are: * differences between patients with covid-19 ards before and after steroid treatment in balf single cell landscape, as well as patients with different prognosis. * differences between covid-19 and non covid-19 ards patients in balf single cell landscape. participants will choose whether to use or not to utilize steroid treatment based on conditions.

collect balf from covid-19 and non-covid-19 ards patients both before and during remission, then perform single-cell sequencing.

Eligibility criteria:
inclusion criteria: * severe ards patients exclusion criteria: * none
observational prospective study to identify intestinal microbial profiles in newly diagnosed crohn's disease patients

Conditions: Crohn Disease

Summary: crohn's disease (cd), a chronic inflammatory disease affecting the intestine, is characterised by a relapsing course. in 25% of cases, the onset of this disease occurs in childhood. relevant studies have provided evidence of a key role of gut microbial communities (the microbiota) in triggering or maintaining active gut inflammation, pointing to gut dysbiosis as the main event disrupting the balance of microbial communities recent evidence suggests that, in addition to the bacterial component, the commensal fungal component also plays a crucial role in cd. the purpose of this prospective, longitudinal, study is to characterise the composition of intestinal bacterial and fungal communities in patients 6-18 years newly diagnosed with crohn disease in order to identify a possible association of specific faecal microbial profiles with a severe or mild-to-moderate disease course.


Eligibility criteria:
inclusion criteria: * children/young people aged between 6 and 18 years with newly diagnosed cm according to recognised diagnostic criteria * obtaining informed consent exclusion criteria: * refusal to participate in the study.
phase i irinotecan, 5-fluorouracil and leucovorin combination

Conditions: Metastatic; Colorectal; Adenocarcinoma

Summary: a phase i open label study to asses the safety and tolerability of zd6474 in combination with irinotecan, 5-fluorouracil and leucovorin (folfiri) as first or second line therapy in patients with metastatic colorectal adenocarcinoma.


Eligibility criteria:
inclusion criteria: 1. confirmed metastatic colorectal adenocarcinoma 2. not amenable to surgery or radiation therapy 3. eligible for first or second line chemotherapy exclusion criteria: 1. brain metastases or spinal compression 2. last prior chemotherapy discontinued within 4 weeks before start 3. last dose radiotherapy within 4 weeks of start

Keywords: zd6474 irinotecan 5-fluorouracil leucovorin colorectal
study of topical superoxide dismutase to treat radiation induced fibrosis

Conditions: Radiation Induced Fibrosis to the Head and Neck

Summary: the purpose of this study is to determine if topical superoxide dismutase is an effective treatment of radiation related neck fibrosis, and to determine the quality of life impact from radiation related fibrosis in the head and neck cancer patients at sanford health.

the primary goal of this study is to evaluate the effect of topical superoxide dismutase (sod) on the radiation induced fibrosis in head and neck cancer patients. a prospective, blinded, two group control design will be used with pretest and post test quality of life as well as objective fibrosis assessment. patients will be randomized to alternatively receive topical sod or placebo as instructed on twice daily use for 3 months. pre and post treatment quality of life surveys and objective assessment will determine if the topical sod improves neck fibrosis/function and global quality of life. this study will increase clinical trial awareness and participation while potentially improving the long term functional outcomes of head and neck cancer patients.

Eligibility criteria:
inclusion criteria: * must have evidence of neck fibrosis * previous radiation treatment to the neck for cancer * age greater than or equal to 18 years * life expectancy of greater than 12 weeks * ability to understand the purpose of the study and the willingness to sign a written informed consent document. exclusion criteria: * history of allergic reactions attributed to compounds of similar chemical or biologic composition to sod or cetaphil cram. * any psychological, familial, sociological or geographical conditions that do not permit medical follow-up and compliance with the study protocol.

Keywords: fibrosis radiation neck cancer sodermix