Kornimate/medical-research-clean huggingface dataset:
development of dysphagia evaluation via video analysis based on deep learning method in neonates and infants and correlation between the evaluation and the development

Conditions: Dysphagia of Newborn

Summary: the purpose of this study is to develop an evaluation of dysphagia through deep learning-based video analysis in newborns and infants, and to report the correlation with future development.

although the exact frequency of dysphagia in newborns is not known, according to a paper published by motion et al. in 2001, the prevalence of eating problems in premature infants under 37 weeks of age was 10.5%, and in 2001, mercado-deane et al. reported that about 26% had dysphagia. in 1996, reilly et al. reported that more than 90% of children with polio had oral movement disorders and 38% had dysphagia. it is known that the frequency of dysphagia in newborns and infants is not low. the risk factors that cause these dysphagia are very diverse, and dysphagia in children can be induced by causes that can affect the whole process of swallowing. the evaluation of dysphagia can be divided into an evaluation method that does not use an instrument such as soma, sds, and quality of life measurement, and an evaluation method that uses an instrument such as vfss and fees. however, it is difficult to conduct tests such as vfss in newborns and infants due to poor coordination, and there is also a risk of radiation exposure. in addition, there are practical difficulties in applying the evaluation in all medical institutions because special facilities are required to implement vfss and specialized clinical personnel are required. the neonatal oral-motor assessment scale (nomas), developed by marjorie meyer palmer in 1983, is an evaluation method for dysphagia applicable to infants under 48 weeks of pma that evaluates whether there are abnormal findings by observing sucking for 5 minutes. however, nomas has the disadvantage that a person has to directly observe the sucking and may show differences in results between raters. therefore, in this study, inspired by the evaluation method of nomas, investigators try to develop an evaluation method to evaluate swallowing disorders by videotaping bottle feeding in newborns and infants, then calculating and analyzing the features of the baby's face related to swallowing with artificial intelligence. investigators would like to analyze the relationship between this evaluation result and future development.

Eligibility criteria:
inclusion criteria: * newborns and infants under 6 months of correctional age * clinically suspected to have dysphagia * in case parental consent is obtained exclusion criteria: * in case of cardiopulmonary instability (ecmo, ventilator, etc. are being applied) * when it is not possible to secure sufficient fields for artificial intelligence analysis of images due to factors such as anatomical abnormalities of the head and neck
dna analysis of tissue from patients with t-cell acute lymphoblastic leukemia

Conditions: Leukemia

Summary: rationale: studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in dna and identify biomarkers related to cancer. purpose: this laboratory study is looking at tissue samples from patients with t-cell acute lymphoblastic leukemia.

objectives: * identify the transcriptional signatures associated with the presence of notch1 mutations in primary t-cell acute lymphoblastic leukemia (t-all) cells using oligonucleotide microarrays. * characterize the global changes on gene expression resulting from the inactivation of notch signaling in human t-all lymphoblasts. outline: this is a multicenter study. frozen lymphoblast samples from patients with t-cell acute lymphoblastic leukemia (notch1-mutated and wild type) are assessed for genetic expression profiles and mutations by microarray analysis and activated notch1 protein by western blot analysis. projected accrual: a total of 48 samples from patients will be accrued for this study.

Eligibility criteria:
disease characteristics: * confirmed diagnosis of t-cell acute lymphoblastic leukemia * frozen lymphoblast samples available * notch1-mutated or wild type sample available patient characteristics: * not specified prior concurrent therapy: * not specified exclusion criteria: * not applicable

Keywords: t-cell adult acute lymphoblastic leukemia t-cell childhood acute lymphoblastic leukemia untreated adult acute lymphoblastic leukemia untreated childhood acute lymphoblastic leukemia recurrent adult acute lymphoblastic leukemia recurrent childhood acute lymphoblastic leukemia adult acute lymphoblastic leukemia in remission childhood acute lymphoblastic leukemia in remission
evaluation of osteopathic care after rupture of the antero-external cruciate ligament of the knee (didt osteo)

Conditions: Cruciate Ligament Rupture; Knee Ligament Injury; Osteopathia

Summary: the antero-external cruciate ligament (acl) is the ligament located inside the knee, which allows the rotation of the knee by stabilizing the femur and the tibia. rupture of the acl is common during the practice of certain so-called "pivot" sports, whether contact or not. it is manifested by acute pain or instability of the knee, following a crack during a twist and/or a blockage of the joint. the diagnosis will be confirmed by a clinical examination and x-rays to eliminate any fracture or tearing and by mri to visualize the ligament rupture and the associated lesions, in particular a lesion of the meniscus. treatment is required because the ruptured ligament does not heal on its own and the rupture of the ligament may eventually promote the appearance of osteoarthritis. two types of treatment can be considered, rehabilitation or surgery, depending on the patient's age and motivation to resume sports. there are several surgical techniques, the most common is to reconstruct the ruptured ligament by arthroscopy using a graft taken from the tendons of the internal rectus and demi muscles tendinous (didt). rehabilitation by physiotherapy is often started preoperatively and immediately after the operation, as soon as you wake up, to find a functional and painless knee. functional recovery often depends on patient motivation. the main objective is to show that osteopathic care in addition to physiotherapy rehabilitation improves knee functionality in patients 6 months after reconstruction of the acl by didt.


Eligibility criteria:
inclusion criteria: * patient, male or female, aged 18 to 35 inclusive * patient with a bmi between 18.5 and 30 kg/m² (limits included). * patient presenting with a total rupture of the unilateral anterior cruciate ligament (acl). * candidate patient for reconstruction of the acl with the didt method. * affiliated patient or beneficiary of a social security scheme. * patient having been informed and having given their free consent, enlightened and written. exclusion criteria: * patient with damage to another structure of the knee, other than meniscal lesions. * patient with a contraindication to osteopathic intervention. * patient for whom a method other than didt has been proposed. * patient with iterative rupture of the acl. * patient having undergone ligamentoplasty of the contralateral knee * patient participating in another research. * patient in period of exclusion from another research still in progress at the time of inclusion. * protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision. * pregnant, breastfeeding or parturient women. * patient hospitalized without consent.
dairy lipids, proteins, and the metabolic syndrome - "dairyhealth"

Conditions: Metabolic Syndrome; Type 2 Diabetes; Cardiovascular Disease; Abdominal Obesity

Summary: dairy food contains a large amount of long-chain saturated fat, which traditionally has been linked to increased risk of cardiovascular disease (cvd). however, recent data indicates a more neutral role. milk fat contains large amounts of medium-chain saturated fatty acids (mc-sfa), which may have beneficial effects on human health. in addition, milk proteins and in particular whey proteins have been shown to have a beneficial effect on glucose disposal as well as anti-inflammatory properties. therefore dairy products have a potential role in the treatment of the metabolic abnormalities of metabolic syndrome (mes). however, human data from intervention studies are lacking. aims of this project is to explore and understand the influence on human health of both medium-chain saturated fatty acids from milk fat and bioactive milk proteins per se as well as their interaction and potential positive synergy on the mes. the investigators hypothesize that whey protein and medium-chain saturated fatty acids improve insulin sensitivity, postprandial lipid metabolism, blood pressure and inflammatory stress in humans and that they possess preventive effects on the risk of developing cvd and type 2 diabetes mellitus (t2dm). a total of 64 people with mes or abdominal obesity will be included. the design is a randomized double-blinded, controlled parallel diet-intervention trial. subjects are assigned one of four experimental diets for 12 weeks. the diets consist of either a diet with low levels of mc-sfa + whey protein (lf + whey), a diet high in mc-sfa + whey protein (hf + whey), a diet high in mc-sfa + casein protein (hf + casein) or a diets with low levels of mc-sfa + casein protein (lf + casein). the subjects are advised how to integrate the test foods in their habitual diet, which also continues unchanged. the subjects' energy intake is matched so they are kept weight stable throughout the study.

see above.

Eligibility criteria:
inclusion criteria: metabolic syndrome * central obesity (waist: female ≥ 80 cm; male ≥ 94 cm) * with two or more of the following * fasting triglyceride \> 1.7 mmol/l * hdl-cholesterol; male \< 1.03 mmol/l, female \< 1.29 mmol/l * bp ≥ 130/85 * fasting plasma glucose ≥ 5,6 mmol/l (but not diabetes) or abdominal obesity (waist: female ≥ 80 cm; male ≥ 94 cm) exclusion criteria: * significant cardiovascular, renal or endocrine disease * psychiatric history * treatment with steroids * alcohol- or drug-addiction * pregnancy or lactation

Keywords: medium chain fatty acids saturated fatty acids whey protein casein protein metabolic syndrome type 2 diabetes cardiovascular disease dairy products dietary intervention
ultrasound evaluation of the ivc in addition to clinical assessment to guide decongestion in adhf

Conditions: Heart Failure

Summary: cava-adhf is designed as a prospective, randomized, controlled, patient-blinded, multicenter, parallel-group trial. the objective is to test whether evaluation of the inferior vena cava diameter in addition to clinical assessment is superior compared to clinical assessment alone with respect to the surrogate endpoint of change in nt-probnp from baseline to discharge. the cava-adhf trial is supported by the deutsches zentrum für herz-kreislauf-forschung (dzhk).

only limited evidence is available on the best method to monitor and guide decongestion in acute decompensated heart failure. therefore, no specific guideline recommendations are made in this regard. it is unknown whether an objective congestion marker can be used to guide decongestion or such marker is only of prognostic value by identifying high-risk patients with an advanced disease state. cava-adhf is designed as prospective, randomized, controlled, patient-blinded, multicenter, parallel-group trial and aims to demonstrate effectiveness of inferior vena cava (ivc)-guided decongestion, its feasibility, and to estimate effect size and variability of clinical endpoints following the intention-to-treat principle. after inclusion and exclusion criteria have been checked patients will be randomized: experimental intervention: decongesting treatment guided by clinical assessment and ultrasound evaluation of the ivc diameter. decongestion should lead to a maximal ivc diameter ≤2.1 cm and ivc collapsibility index \>50% in addition to relief of symptoms and signs of congestion before discharge. control intervention: decongesting treatment guided by clinical assessment alone. the ivc ultrasound evaluation is performed, but results are not reported to treating physicians. trial intervention will end with discharge from the index hospitalization. patients will be followed-up for 180 to 210 days after randomization. the cava-adhf trial is supported by the deutsches zentrum für herz-kreislauf-forschung (dzhk).

Eligibility criteria:
inclusion criteria: * hospitalization for adhf with dyspnea ≥nyha iii, peripheral edema, and pulmonary congestion (rales on auscultation or pulmonary vascular congestion on chest radiograph) * age ≥18 years * nt-probnp \>300 ng/l within 24 h after admission * sufficient ultrasound visualization to evaluate ivc * ivcmax \>2.1 cm and ivcci ≤50 % in the baseline assessment within 24 h after admission * capability to sign informed consent personally exclusion criteria: * cardiogenic shock with systolic blood pressure \<90 mmhg plus end-organ hypoperfusion * adhf due to significant arrhythmias * severe pulmonary disease as primary cause of dyspnea * simplified modification of diet in renal disease estimated glomerular filtration rate \<30 ml/min/1.73 m² * need for non-invasive or invasive ventilation support at baseline * pregnancy * participation in another interventional trial regarding heart failure treatment

Keywords: heart failure acute decompensated heart failure congestion inferior vena cava
evaluation of thoracic ultrasound in monitoring pleural drainage in postoperative thoracic surgery

Conditions: Thoracic Ultrasound; Pleural Drain Removal

Summary: the investigator would like to conduct a study in patients undergoing thoracic surgery to evaluate the effectiveness of thoracic ultrasound in the decision to discharge the patient after pleural drain removal.

thoracic drainage is a common and almost systematic practice after thoracic surgery requiring daily management and monitoring until and after its removal. it allows, after opening the pleura, the evacuation of liquid and/or air retained in the pleural cavity. the overall monitoring of the patient after thoracic surgery is based on clinical vigilance combined with thoracic imaging, in particular the chest x-ray which remains the gold standard (reference examination). the removal of the drain is decided according to the quantity and appearance of the evacuated fluid, the persistence of air leaks, etc... a few hours after the removal of the drain, it is routine to perform a chest x-ray before authorizing a possible discharge from the department. this practice does not correspond to an established scientific protocol but is systematically performed in our department before discharge. several studies have defended the place of ultrasound in thoracic imaging and its contribution to the detection of postoperative and intensive care complications. unlike radiography, this technique is non-irradiating, less expensive and more readily available. it allows the detection of pneumothorax, pleural effusions and other complications detectable on x-ray. to our knowledge, the contribution of thoracic ultrasound has not been studied in the decision to authorize the discharge of the patient after removal of the thoracic drain.

Eligibility criteria:
inclusion criteria: patients undergoing thoracic surgery (lung resection, pleural symphysis, biopsy or resection of a mediastinal tumor or ganglion, pleural decortication/decalcification) admitted immediately after surgery in the thoracic surgery department (standard care or continuous care) of the university hospital of limoges. exclusion criteria: * admission to the intensive care unit after thoracic surgery. * pneumonectomy * chest wall surgery * patients \<18 years old * not affiliated to social security * under guardianship or curatorship * pregnant women * not knowing the french language

Keywords: postoperative thoracic surgery discharge decision thoracic ultrasound pleural drain removal chest x-ray thoracic surgery monitoring
evaluation of radiology resident anxiety when beginning emergency room (er) call

Conditions: Anxiety; Stress

Summary: the purpose of this study is to quantify levels of resident anxiety under the current system (take call alone) and compare results to a modified system.

the study purpose is to quantify resident perceptions and feelings under the current 1700 call system (take call alone) and compare those with resident perceptions and feelings under a modified system where two partial shifts are taken with an experienced resident ("buddy call") prior to taking call alone.

Eligibility criteria:
inclusion criteria: * first year radiology residents
comparison of methods of weaning from nasal cpap in preterm infants: a randomized controlled trial

Conditions: Respiratory Distress Syndrome, Newborn

Summary: this study aimed to determine the efficacy of different ncpap weaning strategies in pre-term infants presenting with respiratory distress, and ultimately establishing the best method to withdraw from ncpap.

pakistan, as well as other developing countries, lacks data regarding the weaning protocol of ncpap. ascertaining the best weaning method that could facilitate a shorter duration on nasal cpap and the least length of hospital stay is very much needed. findings of this study would help clinicians to achieve better outcomes for the patients receiving nasal cpap.

Eligibility criteria:
inclusion criteria: * preterm infants * any gender * low birth weight * gestational ages between 28 to below 37 weeks * presented with respiratory distress * neonates with radiological findings suggestive of respiratory distress, congenital pneumonia/sepsis, or transient tachypnea of the newborn (ttn) exclusion criteria: * complex congenital abnormalities like diaphragmatic hernia, cns malformations, intrapartum-related hypoxia, or congenital heart disease. * intraventricular hemorrhage grade iii or iv or low apgar scores (\<4 or 5 at 5 minutes)
a phase i study to assess the pharmacodynamics of oral ar-c165395xx in subjects with type 2 diabetes mellitus (t2dm)

Conditions: Type 2 Diabetes Mellitus

Summary: a study to assess the pharmacodynamics of oral ar-c165395xx after administration of repeated doses for 3 days in subjects with type 2 diabetes mellitus

a single centre, double-blind, randomised, placebo-controlled, cross-over phase i study to assess the pharmacodynamics of oral ar-c165395xx after administration of repeated doses for 3 days in subjects with type 2 diabetes mellitus

Eligibility criteria:
inclusion criteria * provision of informed consent * male or female of non-childbearing potential (postmenopausal, and/or have undergone hysterectomy and/or bilateral oophorectomy or salpingectomy/tubal ligation) aged ≥18. * patients with hba1c ≥7.5 but ≤11% at enrolment visit (visit 1) * ody mass index \>19 to \<38 kg/m2 * he fasting plasma glucose should be in the range of 3-14 mmol/l (54-252 mg/dl, nclusive) on the morning of visit 1. * clinical diagnosis of type 2 diabetes mellitus * metformin as only anti-diabetic treatment, at least for the last 3 months exclusion criteria: * history or sign of any clinically significant disease or disorder which, in the opinion f the investigator, may either put the subject at risk because of participation in the sudy, or influence the results or the subject's ability to participate in the study * any clinically significant abnormalities in clinical chemistry, haematology or urinalysis results as judged by the investigator * aspartate aminotransferase (ast) or alanine aminotransferase (alt) laboratory results \>3x upper level of normal range (uln) clinical diagnosis of type 1 diabetes mellitus and/or history of diabetic ketoacidosis or positive glutamic acid decarboxylase autoantibodies test (gad antibodies test). * patients treated with single insulin therapy within the last 3 months

Keywords: patients glycaemic control on metformin
asymptomatic brain metastasis in non-small cell lung cancer (nsclc)

Conditions: Non-small Cell Lung Cancer

Summary: the prognosis of nsclc patients with asymptomatic brain metastasis, who are not treated with srs or wbrt has not been fully investigated yet. this randomized phase iii trial is conducted to determine the exact role of srs in nsclc patients with asymptomatic oligo brain metastases whether early treatment with srs would improve survival even in patients with asymptomatic brain metastasis.


Eligibility criteria:
inclusion criteria: * histologically confirmed non-small cell lung cancer with synchronous brain metastases (diagnosis of brain lesion before or within 2 months from diagnosis of the primary site tumor) * one to 4 intraparenchymal brain metastases by contrast-enhanced mri, meeting the following criteria: 1. well circumscribed tumor(s) with brain edema grade 0-1 2. maximum diameter ≤ 3.0 cm * no prior complete resection of all known brain metastases or rt ④ no leptomeningeal metastases by mri or cerebrospinal fluid evaluation * patients without any symptoms or signs from brain metastases (rtog neurologic functions status of 0) ⑥ age, 18 and over ⑦ ecog performance status 0-1 ⑧ written informed consent exclusion criteria: * severe co-morbid illness and/or active infections ② pregnant or lactating women * rtog neurologic function status of 1\~4 ④ uncontrollable extracranial metastases

Keywords: non-small cell lung cancer asymptomatic brain metastasis stereotactic radiosurgery (srs)
cognitive function and postoperative quality of recovery

Conditions: Perioperative Neurocognitive Disorders; Postoperative Quality of Recovery

Summary: this study aims to assess the association between perioperative cognitive function and postoperative quality of recovery.


Eligibility criteria:
inclusion criteria: * elective non-cardiac surgery * age ≥65 years * duration of surgery ≥60 years exclusion criteria: * inability to give informed consent

Keywords: cognitive function
cardioinsight 1 rbbb

Conditions: Heart Failure

Summary: cardiac resynchronization therapy (crt) is an established therapy for symptomatic heart failure patients. however, there are still 30 to 40% of studied patients being nonresponder to crt. the plausible reasons of lack of effect of crt in these patients include relative less baseline electrical dyssynchrony. the aim of our study is to investigate whether there is an optimal configuration of crt delivery that varies between patients with different pattern of activation delay.


Eligibility criteria:
inclusion criteria: * adult (aged 18 or above) of both sexes * ischemic or non-ischemic cause of heart failure * qrs duration \> 120 ms, non-left bundle branch block (lbbb) type of conduction disturbance * nyha class iii or above * informed consent by the patient * already received stable dose of guideline directed medical therapy for at least 3 months exclusion criteria: * lbbb patients * pregnant women * participation in another study * patient with contraindication to left ventricle catheterization by a retrograde aortic approach
clinical intervention psychosis and addiction

Conditions: Psychosis; Substance Abuse

Summary: the purpose of this study is to evaluate an integrative therapeutic concept for schizophrenic patients with comorbid substance use disorder.


Eligibility criteria:
inclusion criteria: * schizophrenia * addiction * written statement of agreement * majority exclusion criteria: * acute psychosis * further neuropsychiatric disorder

Keywords: klips