Kornimate/medical-research-clean huggingface dataset:
the effect of cycling off criteria during pressure support ventilation in chronic obstructive pulmonary disease (copd) patients

Conditions: Chronic Obstructive Pulmonary Disease

Summary: the investigators' aim is to study the effect of cycling off criteria during pressure support ventilation in copd patients at two levels of peep and psv.

in this study two levels of cycling off criteria at two levels of peep and psv were tested in term of gas exchange, respiratory mechanics, work of breathing and patient comfort.

Eligibility criteria:
inclusion criteria: * stable copd patients during invasive mechanical ventilation exclusion criteria: * hemodynamic instability, * paralysis

Keywords: gas exchange pressure support ventilation respiratory mechanics copd patients
c tracker, hepatitis c, care & collaboration - patient reported outcomes survey study

Conditions: Hepatitis C

Summary: today's mobile devices (especially smartphones) are powerful ways to communicate new information to medical researchers. for this study, researchers at boston children's hospital are asking people with hepatitis c to make use of their smartphones to help report information about themselves that may improve how hepatitis c is treated. this study uses a free app called c tracker that can be installed from the apple app store onto the participants iphone. the main goal of this research study is to use this app to report hepatitis c related health information to the researchers who are conducting this study. the investigators will ask participants about their health,activities, medications, and ways in which hepatitis c has impacted you. this information will be reported anonymously, which means that the researchers doing the study won't know who the participants are.

specific aims/objectives aim 1. develop a free iphone app ("c tracker") designed to anonymously record and report hepatitis c related health data to study investigators via periodic patient-reported surveys. aim 2. examine the feasibility of enrolling a large cohort of geographically dispersed cohort of subjects with hepatitis c who download and install the c tracker app, provide informed consent using the app, and complete study surveys using the app. the app will be made available to the public via the apple app store at no cost. aim 3. pilot usage of the app to track and analyze longitudinal measures of hepatitis c related health concerns, physical function, and physical activity via selected disease-specific as well as more broadly applicable patient-reported instruments, including regarding work productivity (wpai-hepatitis c), physical functioning (subsets/subscales of the mos sf-36), physical activity (collected through apple healthkit), and prescribed medications.

Eligibility criteria:
inclusion criteria: * self-report a diagnosis of hepatitis c * english speaking individuals * 18 years or older * must have access to an iphone that operates on ios version 8 or higher * be able to download apps from the u.s. apple iphone store, and enter data themselves or via a proxy on their behalf exclusion criteria: • individuals not meeting inclusion criteria will be excluded.

Keywords: hepatitis c smartphone app tracker c tracker
effectiveness of the nicotine patch in suppressing nicotine withdrawal symptoms in women versus men - 1

Conditions: Smoking Cessation; Tobacco Use Disorder

Summary: women typically have a more difficult time quitting smoking than men. little research has been done to understand the differences between men and women that may cause this distinction. this study will assess whether the reduced effectiveness of nicotine replacement therapy in women is caused by gender differences in the withdrawal suppression induced by nicotine replacement therapy.

smoking can cause a variety of cancers, cardiovascular disorders, and other health problems. quitting smoking greatly decreases one's risk for these problems. studies have shown, however, that quitting smoking is more difficult for women than men. despite that knowledge, little research has been done to try to understand the mechanistic differences between men and women that may cause this distinction. this study will assess whether the reduced effectiveness of nicotine replacement therapy in women is caused by physical and psychological gender differences in the withdrawal suppression induced by nicotine replacement therapy. participants in this double-blind study will attend 4 treatment sessions, each approximately 6.5 hours long and each corresponding to one of four transdermal nicotine replacement patch doses (0, 7, 21, or 42 mg). sessions will be separated by at least 48 hours to avoid carryover effects. immediately following arrival at each session, participants' expired air carbon monoxide (co) levels will be measured to verify that the participant has not smoked for at least 8 hours prior to the visit. if the co level meets the necessary criteria to proceed, a baseline blood sample will be obtained, followed by additional blood samples every 30 minutes. baseline nicotine withdrawal levels will be assessed using questionnaires. computerized recordings of physiological responses will also commence and will continue throughout the session. these response measures will include heart rate, percent oxygen saturation, skin temperature, systolic and diastolic blood pressure, and mean arterial pressure. upon completion of baseline measures, participants will receive a randomly assigned dose of nicotine replacement therapy, in the form of three patches placed on the participants' back. the patches will be removed after 6 hours and the participant will be assessed for any residual effects from the medication.

Eligibility criteria:
inclusion criteria: * smokes at least 15 cigarettes a day for at least 2 years prior to enrollment * has an afternoon carbon monoxide level of at least 15 ppm * agree to use an effective form of contraception for the duration of the study exclusion criteria: * history of chronic health problems * history of psychiatric conditions * history of or active cardiovascular disease * history of or active high or low blood pressure * history of or active seizure condition * history of or active peptic ulcers * history of or active diabetes * pregnant * score of greater than 17 on the beck depression inventory

Keywords: tobacco
retrospective evaluation of total hip replacement after acetabular fractures

Conditions: Total Hip; Acetabular Fracture

Summary: in 1965, emile letournel and robert judet reported their experiences on acetabular fractures at the 5th day of the raymond poincaré hospital in garches. classification letournel is still relevant and in use today. many studies have sought to determine if the treatment had to be surgical or orthopedic. although the standard treatment of displaced fractures of the acetabulum is the reduction and osteosynthesis, some advocate the tha in elderly patients with comminuted fracture of the acetabulum, impaction of the femoral head or acetabular impaction affecting more than 40% of the articular surface and including bearing zone. all these treatments and those supported have been studied in the literature. however the study of the laying of total hip remote trauma after acetabular fracture osteosynthesis or treated conservatively, is not rich in literature. only a few articles have been published in recent years. indeed, a recent review of the literature are nearly 11 series focusing on the results remotely hip prostheses for treatment of acetabular fracture. these two prospective series with between 21 and 63 patients. all authors report rates well above those reported complications for primary arthroplasty, with a revision of rates ranging between 0 and 26.5%. fractures of the acetabulum are covered in our service by one operator using the same release technique based on the stiffening. the objective of this study is to determine whether the systematic surgical treatment of these patients by an experienced operator reduces the high complication rate.

ii. objectives: 1. evaluation of the rate and type of complications intraoperative and postoperative, and revision rates. 2. evaluation of clinical results based on surgical strategies. iii. methodology this is a single-center retrospective study single-operator regarding the evaluation of surgical practice cited in goal. patients were aware of the potential use of their data for medical research through oral information provided by the doctor at the signing by the patient's consent related to the surgery. iv. nature of the data collected the data is anonymous and unidentifiable. data collected include: * the characteristics of the patient, as well as its history, * the particular technical operating data, * the nature of possible post-operative complications * the clinical and radiological assessment at follow: ap pelvic radiograph, harris score and score postel merle d'aubigné.

Eligibility criteria:
inclusion criteria: * patients who have had a fracture of the acetabulum ostéosynthèsée treated conservatively or who had a total hip replacement by secondary intention. * operated at st. joseph's hospital between 2005 and 2013 * decline minimum of one year. exclusion criteria: • total first-line hip arthroplasty following fracture of the acetabulum made within two months following the date of the initial trauma.
neurocognitive exercise program for children with attention deficit and hyperactivity disorder

Conditions: Attention Deficit Hyperactivity Disorder

Summary: the effects of neurocognitive exercise program (nep) on adhd symptoms and executive functions in children with attention deficit and hyperactivity disorder (adhd) will be investigated using the conners parent rating scale-revised short (cprs-rs), stroop test, wisconsin test and y-balance test.

the effects of neurocognitive exercise program (nep) on adhd symptoms and executive functions in children with attention deficit and hyperactivity disorder (adhd) will be investigated. material and methods: twenty-nine boys (14 adhd, 15 healthy controls) between 7 and 13 years of age will be recruited in the study and the conners parent rating scale-revised short (cprs-rs), stroop test, wisconsin test and y-balance test will be performed . all tests and measurements will be performed for adhd group before nep, after nep, 6 months and 12 months. the control group will be evaluated only once.

Eligibility criteria:
inclusion criteria: * children between 7-13 years old * diagnosis of adhd given by an experienced child psychiatrist based on the 5th edition of diagnostic and statistical manual of mental disorders (american psychiatric association, 2013) exclusion criteria: * presence of anxiety, * presence of depression, * presence of learning disability, * presence of intellectual disability, * presence of visual impairment, * presence of musculoskeletal or neurological disorders that may directly affect motor skill and cognition
multiple-ascending dose study

Conditions: Depression

Summary: the purpose of this study is to determine the safety and tolerability of bms-820836 after multiple doses


Eligibility criteria:
inclusion criteria: * panels 1-6: healthy male subjects * panel 7: females * ages 21 to 55, inclusive * body mass index (bmi) of 18 to 32 kg/m2, inclusive * healthy subjects as determined by no clinically significant deviation from normal in medical history, physical examination, ecgs, and clinical laboratory determinations exclusion criteria: * any major surgery within 4 weeks of study drug administration * history of cholecystectomy * history of glaucoma or a confirmed intraocular pressure indicative of glaucoma at screening. (normal iop \<21 mmhg) * confirmed qtc (fridericia) value ≥ 450 msec * confirmed qt ≥ 500 msec * confirmed pr ≥ 210 msec * confirmed qrs ≥ 120 msec * confirmed resting supine systolic blood pressure \> 140 mmhg * confirmed resting supine diastolic blood pressure \> 90 mmhg * confirmed resting heart rate \ 100 bpm * orthostatic vital sign changes (ie., a decrease in systolic blood pressure from supine to standing \> 40 mmhg and an increase in heart rate from supine to standing \> 20 bpm) or symptoms of orthostasis * history of peppermint allergies * exposure to any investigational drug or placebo within 12 weeks of study drug administration
impact of adipose tissue in covid-19

Conditions: Covid19

Summary: overweight or obese patients are particularly exposed to severe forms of covid-19. few data suggest that adipose tissue infected with sars-cov-2 could be involved in the onset of the cytokine storm seen in severe forms of covid-19. the aim of this study is to determine the pathogenesis of sars-cov-2-infection of adipose tissue. in particular the investigators will study how this virus enters the adipocyte and how it modulates metabolism and inflammation in the adipose tissue. from these data, the investigators hope to determine at the adipose tissue level, original therapeutic targets to modulate the effects of sars-cov-2 at the systemic level.


Eligibility criteria:
inclusion criteria: * age greater than or equal to 18 years * all patients who are obese or overweight (\> 25 kg/m2) or non-obese (\< or = 25 kg/m2) operated for abdominal vascular surgery * beneficiary or entitled to a social security scheme (except ame) exclusion criteria: * pregnant or breastfeeding woman * patient refusal * patient deprived of liberty or subject to a legal protection measure (guardianship, curatorship)

Keywords: adipose tissue covid19 sars-cov2
promoting community reintegration for young adults with stroke

Conditions: Stroke

Summary: this project will investigate the effects of a narrative and skills-building intervention on young stroke survivors' community reintegration and psychosocial outcomes. a randomised controlled trial will be conducted. this is a novel trial to test the short and long-term effects of a theory-based intervention on young stroke survivors' community reintegration.

this project will investigate the effects of a narrative and skills-building intervention on young stroke survivors' community reintegration and psychosocial outcomes. a randomised controlled trial will be conducted. participants will be facilitated to narrate their survival experiences and rebuild core life skills. outcomes including community reintegration, depressive symptoms, health-related quality of life, self-efficacy, outcome expectation and satisfaction with performance of self-management behaviours will be measured. this is a novel trial to test the short and long-term effects of a theory-based intervention on young stroke survivors' community reintegration.

Eligibility criteria:
inclusion criteria: * (1) are 18-64 years of age, * (2) have a clinical diagnosis of first-ever or recurrent ischaemic or haemorrhagic stroke, * (3) are living at home after discharge from hospital, * (4) have a montreal cognitive assessment score \>20, * (5) have a modified rankin scale score ≥3, * (6) can communicate in cantonese, and * (7) are able to attend all intervention sessions. exclusion criteria: * 1) transient ischaemic attack, subdural or epidural haemorrhage, * 2) experienced cerebrovascular events due to tumours or head trauma, * 3) mental condition such as depression, schizophrenia, bipolar or personality disorder, * 4) incomprehensible speech or difficulty in comprehending conversations, or * 5) have received a self-management programme in the past.

Keywords: stroke community reintegration narrative skill building
saline-controlled study of nstride aps for knee osteoarthritis

Conditions: Osteoarthritis

Summary: a double-blind, multicenter, randomized, controlled trial (rct) that will evaluate the efficacy of a single dose of autologous protein solution (aps) in patients with osteoarthritis (oa) of the knee.

a double-blind, multicenter, randomized, saline-controlled trial (rct) that will evaluate the efficacy of a single dose of autologous protein solution (aps) in patients with symptomatic osteoarthritis (oa) of the knee who have not been able to get satisfactory pain relief with prior treatment.

Eligibility criteria:
inclusion criteria: * male or female ≥ 21 and ≤ 80 years old at the time of screening * willingness and ability to comply with the study procedures and visit schedules and ability to follow oral and written instructions * a standing radiograph of the knee showing a kellgren-lawrence grade of 2 to 4 and an absence of severe osteoarthritis * body mass index ≤ 40 * a qualifying womac lk 3.1 pain subscale total score * has undergone at least one prior conservative osteoarthritis treatment * signed an institutional review board approved informed consent exclusion criteria: * presence of clinically observed active infection in the index knee * presence of symptomatic osteoarthritis in the non-study knee * diagnosed with rheumatoid arthritis, reiter's syndrome, psoriatic arthritis, gout, ankylosing spondylitis, or arthritis secondary to other inflammatory diseases; hiv, viral hepatitis; chondrocalcinosis, paget's disease, or villonodular synovitis * diagnosed with leukemia, known presence of metastatic malignant cells, or ongoing or planned chemotherapeutic treatment * untreated symptomatic injury of the index knee * presence of surgical hardware or other foreign body intended to treat arthritis or cartilage-related pathology in the index knee * previous cartilage repair procedure on the injured cartilage surface of the index knee * arthroplasty or open surgery of the index knee within 6 months of screening * intra-articular steroid injection in the index knee within 3 months of screening * intra-articular hyaluronic acid injection in the index knee within 6 months of screening * other intra-articular therapy in the index knee within 6 months prior to screening * orally administered systemic steroid use within 2 weeks of screening * planned/anticipated surgery of the index knee during the study period * skin breakdown at the knee where the injection is planned to take place * pregnant or nursing mothers or women planning on getting pregnant during the time they will be participating in the study * participated in any investigational drug or device trial within 30 days prior to screening * participated in any investigational biologic trial within 60 days prior to screening

Keywords: autologous protein solution aps intra-articular injection osteoarthritis
application of genexpert on bronchoscopic samples in the clinical management of patients suspicious of tb

Conditions: Tuberculosis

Summary: this is a case control observational study using bronchial-alveolar lavage (bal) as specimen for genexpert, a real time polymerase chain reaction (pcr) test for detection of tuberculosis (tb). patients suspicious of tb, who require bronchoscopy as part of the investigation procedures, will be recruited for this study over a period of 18 months. clinical likelihood of tb will be systematically scored according to various clinical parameters. this will determine the pre-test probability. clinician will decide if anti-tb treatment is to be started and patients will be followed up for a minimal of 18 months. sensitivity, specificity, positive, negative predictive values and the respective likelihood ratio will be calculated accordingly.


Eligibility criteria:
inclusion criteria: 1. patients \> 18 years old suspected of tb clinically. 2. patients suspected of tb but both smear microscopy and tb pcr of sputum are negative or sputum cannot be produced. 3. bal samples obtained following standard investigation procedure 4. cxr or ct imaging available. exclusion criteria: 1. bronchoscopy is not planned as a necessary procedure for investigation. 2. diagnosis of active tb has been made by other means.
movicol in childhood constipation (promotion study)

Conditions: Chronic Constipation

Summary: this was a single centre study comprised of two stages (parts i and ii). part ii was a 12 week randomised double blind comparison of movicol and lactulose dry as maintenance therapy on an out-patient basis. the aim was to evaluate the safety and efficacy of movicol in the treatment of faecal impaction in children

two days following disimpaction (part i of the clinical trial) patients were assigned (based on their randomisation number) to receive either movicol or lactulose as maintenance therapy for the remainder of the study. at discharge all patients received the appropriate supply of study medication. this includes 1 week's overage should they miss their next visit to the promotion clinic. they did not know whether they have been randomised to receive movicol or lactulose dry. following discharge patients were contacted after 3-5 days by telephone or home visit (whichever was appropriate) to encourage treatment and to ensure compliance. parents were instructed to contact the pro-motion team who would advise appropriately if patients had any difficulty i.e. none, irregular and/ or uncomfortable or very loose bowel movements. the daily use of movicol or lactulose dry during part ii was recorded in the diary. if the dose of movicol or lactulose was changed by the pro-motion team at any time then it was documented appropriately in the patient notes and the case report form.

Eligibility criteria:
inclusion criteria: * patients that, in the opinion of the investigator, are constipated/faecally impacted as to require hospital stay to treat and/or relieve the impaction * children aged 2 - 11 years old inclusive * patients of either sex exclusion criteria: patients with * intestinal perforation or obstruction * severe inflammatory conditions of the intestinal tract * uncontrolled renal/hepatic/cardiac diseases * uncontrolled endocrine disorder(s) * any neuromuscular condition affecting bowel function * hypersensitivity to lactulose or peg or other constituent of movicol * patients who have taken any investigational drug in the three months * patients or patients whose parents would in the opinion of the investigator are unable to comply with requirements of the study
shoe inserts for treating osteoarthritis of the knee

Conditions: Osteoarthritis, Knee

Summary: this trial will test shoe inserts for the treatment of knee osteoarthritis, the most common form of knee arthritis. those with disease on the inner (medial) aspect of the knee will be studied.


Eligibility criteria:
inclusion criteria: * medial knee osteoarthritis * pain * no foot problems * lives in boston, massachusetts metro area

Keywords: biomechanics
the efficacy of metformin produced by pars mino co in comparison with canadian apotex co.

Conditions: Diabetes Mellitus, Type 2 AND Metformin

Summary: background: metformin is usually using for glycemic control in type 2 diabetes mellitus. different pharmaceutical types of metformin are available. as a clinical trial, we compared the efficacy and complications of metformin produced by "pars mino pharmaceutical company, iran" with "apotex pharmaceutical company, canada", in type 2 diabetic patients. method: 18 eligible women with type 2 diabetes were given metformin "pars mino" or "apotex" (500 mg twice a day) each for 6 weeks period in a randomized, double blind, crossover study. these two groups randomly under treatment with generic metformin (manufactured by pars mino company) or non-generic (manufactured by apotex canada). after 2 weeks washout period another 6 weeks period with another brand of metformin was prescribed. fbs, hba1c, lipid profile (cholesterol, tg, hdl, and ldl), weight, and bmi were assessed before and after each treatment phase. the results were compared with each other by paired sample t-test, independent sample t-test.


Eligibility criteria:
inclusion criteria: * mild hyperglycemia, no contraindication for metformin, poor controlled diabetes exclusion criteria: * creatinine more than 1.5, severe organ damage

Keywords: diabetes mellitus, type 2, metformin, generic, efficacy