Kornimate/medical-research-clean huggingface dataset:
physical condition in lipedema and obesity

Conditions: Lipoedema; Obesity

Summary: the diagnosis of lipoedema and obesity are often mixed up, unclear stated and often there is a misdiagnosis. the primary aim is to investigate whether there is a difference in muscle strength between women with lipedema and women with obesity. the secondary aim is to investigate whether there is a difference in physical fitness between women with lipedema and women with obesity.

lipedema is a genetically mediated disorder of adipose tissue that occurs exclusively in women. lipedema is an under-recognized condition, often misdiagnosed as lymfedema or dismissed as simple obesity. the diagnosis of lipedema is a clinical diagnosis and may be challenging to determine among patients who are obese. measurements of muscle strength and physical fitness may give more clarity to differentiate between lipedema and obesity. this may lead to improvements in the criteria of diagnosing lipedema. the research question of the study is: is there a difference in muscle strength between adult women with lipedema and adult women with obesity? in this study 40 patients will be studied; 20 patients in every group. besides the general data as length, weight, age, abdominal circumference, volume of the legs additional muscle strength and physical fitness of women with lipedema and women with obesity will be measured and analysis. this study doesn't involve a negligible risk for participants. the study will not have direct benefit for the participants, but may be useful in giving more clarity in defining the phenotype for patients with lipedema.

Eligibility criteria:
inclusion criteria: in order to be eligible to participate in this study, a subject must meet all of the following criteria: lipedema group: * diagnosed with lipedema following the criteria of wold et al3 * women * age ≥ 18 years obesity group: * bmi ≥ 30 * women * age ≥ 18 years exclusion criteria: a potential subject who meets any of the following criteria will be excluded from participation in this study: lipedema group: - none obesity group: - an obesity intervention with physical training in the ≤12 months prior to the measurement

Keywords: lipoedema obesity
intracardiac versus transesophageal echocardiography for left atrial appendage occlusion combined with radiofrequency ablation

Conditions: Atrial Fibrillation

Summary: a total of 60 patients with atrial fibrillation were scheduled to receive left atrial appendage occlusion combined with radiofrequency ablation, which were divided into two groups. the operation was performed under the guidance of intracardiac echocardiography and transesophageal echocardiography respectively (allocation ratio 1:1). during the operation, the total amount of contrast medium injected, the fluoroscopy time and the time from femoral vein puncture to transseptal puncture to closure were recorded in all patients. all patients underwent transesophageal echocardiography before and 3 months after operation, and the results were explained by two experienced ultrasound doctors to measure the presence of left atrial thrombus, residual shunt and device-related thrombus. all patients were examined by transthoracic echocardiography 3 months after operation to evaluate new pericardial effusion, pericardial tamponade, instrument embolization / displacement and so on. the baseline clinical and surgical features and hospitalization outcomes of patients guided by ice and tee were recorded and compared. clinical endpoints include death, new pericardial effusion that does not require pericardiocentesis, tamponade with pericardiocentesis, instrument embolism / displacement, bleeding at the entry site, thromboembolic events (stroke / transient ischemic attack \[tia\]), and renal failure requiring dialysis. the purpose of this study was to evaluate the feasibility, safety and effectiveness of intracardiac echocardiographic (ice)-guided and transesophageal echocardiographic (tee)-guided left atrial appendage occlusion combined with radiofrequency ablation. and try to analyze whether intracardiac echocardiography can be used as an alternative to transesophageal echocardiography in transcatheter closure of left atrial appendage. the average follow-up time was 1 year.


Eligibility criteria:
inclusion criteria: sustained af attack occurred in patients with a duration of more than one year, patients taking class i and class iii antiarrhythmic drugs could not prevent af, patients younger than 80 years old cha2ds2-vasc score ≥2, not suitable for long-term oral anticoagulant drugs. exclusion criteria: patients with a history of atrial thrombosis or valvular heart disease (moderate or severe valve stenosis or severe valve regurgitation), patients undergoing prosthetic heart valve replacement, pregnant women, patients with previous liver and kidney diseases, malignant tumors or blood system diseases.

Keywords: transesophageal echocardiography intracardiac echocardiography left atrial appendage closure combined with radiofrequency ablation atrial fibrillation
the efficacy of pain control after total hip replacement between ultrasound guided supra-inguinal fascia iliaca block and intrathecal morphine

Conditions: Total Hip Replacement; Ultrasound Guided Supra-inguinal Fascia Iliaca Block; Intrathecal Morphine; Postoperative Pain

Summary: total hip replacement is one of major orthopedic surgery which result in severe postoperative pain especially at first 24 hours. ultrasound guided regional anesthesia has become a part of multimodal analgesia.ultrasound guided supra-inguinal fascia iliaca block is a new technique which can consistently cover femoral and lateral femoral cutaneous nerve. and with large volume (40ml), it may cover obturator nerve. this technique already proved to be useful for acute pain control in hip fracture or postoperative control in dynamic hip screw or nail insertion operation. however, it has not been compared with intrathecal morphine for total hip replacement yet.

by using combine ultrasound guided supra-inguinal fascia iliaca block with periarticular infiltration with mutimodal analgesic drugs will have longer duration time to first rescue analgesic drug compared with combine intrathecal morphine with periarticular infiltration with multimodal analgesic drugs.

Eligibility criteria:
inclusion criteria: * elective surgery of primary total hip replacement, body weight ≥40kg and bmi ≤35 kg/m2, competence to consent exclusion criteria: * contraindication to regional anesthesia, allergy to study drugs, skin infection at supra-inguinal fascia iliaca injection point, neurological deficit affecting the lower extremities, inability to use patient-controlled analgesia, gfr \<50 ml/min

Keywords: total hip replacement ultrasound guided supra-inguinal fascia iliaca block intrathecal morphine postoperative pain
evaluation of a resident curriculum in firearm injury prevention

Conditions: Injury; Training

Summary: the purpose of this project is to evaluate the efficacy of a web-based curriculum designed to teach pediatric practitioners how to provide injury prevention anticipatory guidance, emphasizing firearm injury prevention in a clinic setting. data will be collected regarding the curriculum's effectiveness using a web-based questionnaire which will be administered to pediatric residents prior to, immediately post, and six months following completion of the curriculum. pre- and post-test questionnaires will be compared. residents will also be asked to evaluate the curriculum by completing a survey. we hypothesize that the curriculum will improve residents' knowledge, attitudes and beliefs, and self-efficacy regarding firearm injury prevention anticipatory guidance.


Eligibility criteria:
inclusion criteria: * pediatric resident at children's memorial hospital exclusion criteria: * none

Keywords: injury prevention firearms training counseling medical education safety anticipatory guidance firearm injury prevention anticipatory guidance
peng block for arthroscopic hip surgery

Conditions: Postoperative Pain; Hip Arthroscopy

Summary: this randomized, double-blinded, placebo-controlled trial seeks to evaluate the analgesic efficacy of the pericapsular nerve group block in the setting of outpatient hip arthroscopy.

the pericapsular nerve group, or peng block, has been recently described and shows promise in providing analgesia to the hip joint. the analgesic value of this block in the setting of hip arthroscopy is unknown. this study aims to compare a preoperative peng block to placebo block prior to outpatient hip arthroscopy under general anesthesia. the primary outcome measure is immediate postoperative pain as measured by numerical rating score in the post-anesthesia care unit (pacu). secondary outcomes include opioid consumption, opioid-related adverse events, patient satisfaction, chronic opioid usage, and pain scores at other time points.

Eligibility criteria:
inclusion criteria: * patients \> 18 years old undergoing unilateral hip arthroscopy at the outpatient surgery center. exclusion criteria: * refusal to participate * \< 18 yo * chronic opioid use * localized infection

Keywords: pericapsular nerve group block, peng, hip arthroscopy, pain
chronic effects of local vibration on neuromuscular reconditioning after anterior cruciate ligament reconstruction

Conditions: Anterior Cruciate Ligament Reconstruction

Summary: these last years, it has been proven that the solicitation of a muscle using vibration may lead to positive effects on the neuromuscular function. thus, the aim of the current study is to assess if the addition of local vibration training sessions on the quadriceps muscle to the classic readaptation program (i.e. physiotherapist sessions) may allow a better recuperation 2 months after the surgery and the reconstruction of the anterior cruciate ligament. the aim of the vibration training proposed in the current study is to allow a better recuperation 2 months after the anterior cruciate ligament reconstruction when compared with conventional physiotherapy alone.


Eligibility criteria:
inclusion criteria: * undergoing to surgery (i.e. ligamentoplasty) of the anterior cruciate ligament exclusion criteria: * taking neuro-active substances which can lead to alteration of the corticospinal excitability * contra indications for using magnetic stimulation * participating in another study in the same time

Keywords: anterior cruciate ligament reconstruction local vibration training ligamentoplasty anterior cruciate ligament corticospinal excitability elastography knee extensor muscles readaptation
7-day compared with 10-day antibiotic treatment for febrile urinary tract infections in children

Conditions: Urinary Tract Infections in Children

Summary: the investigators aim to assess the effectiveness of a 7-day compared with a 10-day course of antibiotic treatment for febrile urinary tract infections (utis) in children. it is formulated a hypothesis that a 7-day course of antibiotic therapy is equally effective as a 10-day course of therapy and would entail a lower risk of adverse events and better compliance.

in previously published european and global guidelines, there has been no consensus among experts regarding the duration of therapy for a febrile uti. depending on the recommendation, the duration of treatment should be between 7-14 days. 221 patients aged 3 months to 7 years with febrile utis (defined as a combination of fever and leukocyturia in urine sediment) will be randomly assigned to receive a 7-day treatment arm (7 days of cefuroxime/cefuroxime axetil followed by 3 days of blinded placebo) or a 10-day treatment arm (7 days of cefuroxime/cefuroxime axetil followed by 3 days of blinded cefuroxime axetil). the primary outcome measure will be frequencies of recurrence and reinfection of uti during the 6 months after the intervention. the secondary outcome measures will be antibiotic-associated diarrhea and compliance.

Eligibility criteria:
inclusion criteria (must have all): * children aged from 3 months to 7 years * clinical diagnosis of a febrile uti at presentation according to urinalysis (white blood cells in the sediment \>10 in the field of view); * fever ≥38°c * positive urine collection with sensitivity for cefuroxime * treatment cefuroxime or cefuroxime axetil for 7 days exclusion criteria (must have one): * history of a uti in the last 3 months * prophylaxis for uti * antibiotic therapy in the last month * known allergy to the study drugs * immunosuppression therapy * disease with immune deficiency * children with other coexisting infection, e.g. meningitis, sepsis, pneumonia, otitis * severe obstructive uropathy

Keywords: urinary tract infections pyelonephritis cefuroxime children
cancer experience registry (cer) for cancer patients and caregivers

Conditions: Neoplasms; Cancer; Caregiver

Summary: the cancer experience registry®: an online survey research study to understand the experiences of those impacted by a cancer diagnosis. the registry is a web-based platform to distribute cross-sectional and longitudinal surveys. study surveys are designed based on input from advisor experts, including patients and caregivers, and focus on the social, emotional, physical, financial and decision-making experiences of those who have been diagnosed with cancer and their caregivers. findings contribute toward enhancing care for patients, survivors and caregivers via programming and policy initiatives.

the aims of the registry are to: 1) better understand the psychosocial experiences and needs of people who have been impacted by cancer, including patients, survivors and caregivers; 2) inform the research community, healthcare providers, patient advocates and policy makers around gaps in care and the psychosocial challenges of people affected by cancer; 3) use the findings to develop and disseminate tailored (data-guided) programs and services that will address the emotional and social needs and ultimately improve the long-term quality of life of people affected by cancer; 4) link registrants to cancer related resources and programs via an online, modifiable platform; and 5) provide collaborating sites (e.g., hospitals/health networks/csc affiliates) with aggregated reports on quality and needs of members or customers to enhance or improve quality of care. findings from the registry are disseminated online at https://www.cancersupportcommunity.org/sites/default/files/file/2020-07/csc_registry_report_june_2020.pdf

Eligibility criteria:
inclusion criteria: * have received a cancer diagnosis or have been a family caregiver or informal caregiver (i.e., a relative or friend) for someone diagnosed with cancer * live in united states, a us territory, or canada * able to read and understand english exclusion criteria: * none

Keywords: cancer cancer survivorship psychosocial needs cancer experience acute myelogenous leukemia breast cancer breast cancer, metastatic chronic lymphocytic leukemia chronic myeloid leukemia liver cancer lung cancer melanoma multiple myeloma myelodysplastic syndrome ovarian cancer prostate cancer stomach cancer bladder cancer colorectal cancer patient insights
bicalutamide (casodex™) versus placebo in patients with early prostate cancer

Conditions: Non-metastatic Prostate Cancer

Summary: the purpose of this trial is to study the effect - in terms of time to progression and overall survival - of 2 years of adjuvant bicalutamide 150mg monotherapy, versus placebo, in subjects with histologically or cytologically confirmed non-metastatic adenocarcinoma of the prostate gland.


Eligibility criteria:
inclusion criteria: * prostate cancer in the early stage of disease * prostate removed and/or radiation therapy to the prostate area exclusion criteria: * previous systemic therapy for prostate cancer * previous history of another form of cancer (not prostate) within 5 years of study start.

Keywords: androgen antagonists prostate neoplasms
cataract surgery on advanced age related macular degeneration patients

Conditions: Cataract; Macular Degeneration Advanced

Summary: the degree at which cataract surgery improves visual function in patients with advanced age-related macular degeneration (advanced amd) has been an on-going topic of discussion. our objective in this study is to determine if patients with advanced amd and concurrent cataracts will experience greater improvement in their quality of life from having cataract surgery on one or both eyes. the findings from this project will provide evidence for clinical decision making on whether performing bilateral cataract surgery on advanced amd patients is cost-effective and worth the second surgical intervention.


Eligibility criteria:
inclusion criteria: patients above the age of fifty with both advanced amd and cataracts bilaterally from the okanagan valley will be selected for this study. patients who chose to have bilateral cataract surgery, were able to understand the research parameters, and had no other severe eye disease that may distort the studies results. patients will be selected for the study according to the national eye institute definition of advanced amd. "advanced amd (areds category 4) is characterized by one or more of the following (in the absence of other causes) in one eye: geographic atrophy of the rpe involving the foveal center. neovascular maculopathy that includes the following: * choroidal neovascularization (cnv) defined as pathologic angiogenesis originating from the choroidal vasculature that extends through a defect in bruch's membrane * serous and/or hemorrhagic detachment of the neurosensory retina or rpe * retinal hard exudates (a secondary phenomenon resulting from chronic intravascular leakage) * subretinal and sub-rpe fibrovascular proliferation * disciform scar (subretinal fibrosis)" exclusion criteria: * severe intraoperative or postoperative complications such as retinal detachments, and capsule ruptures * inability to complete the required testing (auto-refractive and visual acuity) * inability to attend appointments * inability to complete the questionnaire with co-i assistance * severe eye disease that may distort the studies results such as but not limited to epithelial basement membrane dystrophy (ebmd) and retinal detachments.
the influence of complex correction of dental and musculoskeletal systems on the frequency of relapses of functional disorders in patients with dental pathologies.

Conditions: Malocclusion; Musculoskeletal Disorder

Summary: in influence of complex correction of dental and musculoskeletal systems on the frequency of relapses of functional disorders in patients with somatic pathologies: a randomized pilot study there will be two groups: group 1 (control group): patients in this group will receive standard treatment aimed solely at correcting malocclusions or restoring the integrity of the dentition without interfering with the musculoskeletal system. group 2 (experimental group): patients will receive comprehensive treatment, including not only dental correction of bite or restoration of the integrity of the dentition, but also correction of disorders of the musculoskeletal system. the endpoints will be : primary endpoint: • frequency of relapses and repeated requests for correction of disorders bite or restoration of the integrity of the dentition within 12 months after treatment. secondary endpoints: * change in pain intensity measured by visual analog scale (vas). * improvement of functional indicators of the temporomandibular joint, including range of motion. * improved quality of life, assessed using the ohrqol (oral health related quality) scale all endpoints will be evaluated within 12 months.


Eligibility criteria:
inclusion criteria: * diagnosed malocclusion or dentition insufficiency, confirmed by a dentist. * presence of diseases of the musculoskeletal system, confirmed orthopedist or rheumatologist. * acquired limb deformities (for example, flat feet, valgus or varus deformity). * deforming dorsopathies (kyphosis, lordosis, scoliosis, osteochondrosis). * consent to participate in the study and follow the treatment protocol. * sufficient general physical and mental fitness to participate in the study exclusion criteria: * systemic diseases affecting bone metabolism (eg osteoporosis). * progressive neurological diseases. * current treatment with steroids or immunosuppressive drugs. * presence of malignant neoplasms. * psychiatric disorders that prevent compliance protocol. * pregnancy or lactation period. * carrying out dental or orthopedic treatment in recent 6 months. * skeletal malocclusions. * diseases of the temporomandibular joint. * congenital pathologies of the musculoskeletal system. * arthropathy. * systemic connective tissue diseases. * biomechanical lesions of the musculoskeletal system.

Keywords: malocclusion musculoskeletal disorders orthodontics dental prosthetics complex correction of the dental system
a comparative study between intrathecal dexmedetomidine vs ketamine with intrathecal bupivacaine in orthopedic lower limb surgeries.

Conditions: Bone Fracture

Summary: orthopedic anaesthesia and acute postoperative pain management, two anesthesiology subspecialties,are getting more credit for reducing hospital stays, promoting functional recovery and improving patient satisfaction.


Eligibility criteria:
inclusion criteria: -the study will include 100 adult patients (18 to 50 years old) with asa physical status class i and class ii undergoing orthopedic lower limb surgeries under itrathecal anathesia . exclusion criteria: * patient refusal. * drug abuse. * patient with neurological, psychiatric or neuromuscular disease. * chronic pain on medicine. * known allergy to the study medications. * patients e contraindications to intrathecal anesthesia .