Kornimate/medical-research-clean huggingface dataset:
use of viscoelastic tests in the treatment of traumatic induced coagulopathy: a pragmatic randomized clinical trial.

Conditions: Trauma, Multiple; Coagulopathy; Massive Hemorrhage

Summary: trauma is the leading cause of death in young people. trauma-induced coagulopathy (tic) encompasses several aspects of traumatic bleeding. monitoring of coagulopathy comprises use of point-of-care (poc) methods, such as thromboelastography (teg) or thromboelastometry (rotem) and conventional laboratory assays (platelet count, fibrinogen level, and pt or inr). poc tests are thought to have a better performance on mortality and bleeding control than conventional tests. the aim of this study is to compare poc and conventional assays with plasma consumption as a primary outcome and 28 days mortality as a secondary one.


Eligibility criteria:
inclusion criteria: all adult (\> 18 years old) trauma patients treated in our emergency department with a tash score \> 18 exclusion criteria: * dead on arrival * no blood product administered after randomization

Keywords: trauma-induced coagulopathy
study evaluating the efficacy and safety of povorcitinib in adults with chronic spontaneous urticaria

Conditions: Urticaria; Chronic Spontaneous Urticaria; Chronic Idiopathic Urticaria; Hives; Angioedema; Pruritis

Summary: this study is being conducted to evaluate the efficacy and safety of povorcitinib in adults with csu that is inadequately controlled using soc treatments.


Eligibility criteria:
inclusion criteria: participants are eligible to be included in the study only if all of the following criteria apply: * csu diagnosis for ≥ 3 months prior to screening. * csu refractory to second-generation h1 antihistamines * participants must have been on a stable dose of second-generation h1 antihistamine, and must agree to maintain the stable dose of second-generation h1 antihistamine throughout study. * willingness and ability to comply with the study protocol and procedures. * further inclusion criteria apply exclusion criteria: * treatment with an anti-ige biologic (eg, omalizumab) within 8 weeks prior to screening. * clearly defined underlying etiology for chronic urticarias other than csu * other cutaneous or systemic diseases with chronic itching or with symptoms of urticaria or angioedema. * women who are pregnant (or who are considering pregnancy) or breastfeeding. * concurrent or history of thrombocytopenia, coagulopathy, or platelet dysfunction, venous and arterial thrombosis, deep vein thrombosis, pulmonary embolism, stroke, moderate to severe heart failure (nyha class iii or iv), cerebrovascular accident, mi, coronary stenting, or cabg surgery, other significant cardiovascular diseases or uncontrolled hypertension * recipient of an organ transplant that requires continued immunosuppression. * any malignancies or history of malignancies with the exception of adequately treated or excised nonmetastatic basal cell or squamous cell cancer of the skin, or cervical carcinoma in situ. * chronic or recurrent infectious disease. * further exclusion criteria apply.
evaluating vertebroplasty and kyphoplasty for reducing trauma-related fractures

Conditions: Vertebral Body Compression Fractures

Summary: the primary objective of this study is to compare the volume of injected ciment (polymethyl methacrylate) between a group of patients treated with vertebroplasty and a group of patients treated via kyphoplasty. secondary evaluation will compare the restoration of vertebral height, volume and cyphotic angle between the two techniques, as well as extravation of ciment and functional and quality of life aspects related to these techniques.


Eligibility criteria:
inclusion criteria: * the patient must have given his/her informed and signed consent * the patient must be insured or beneficiary of a health insurance plan * the patient is available for 3 months of follow-up * fracture type according to magerl classification (1994) must be one of the following: a1, a2.1, a3.1, a3.2 * cyphose of \>10° * spinal pain * vertebral fracture \< 3 weeks old located between d5 and l5 * if fragments in the canal, they must protrude less than 40% * absence of other lesions, including cancer exclusion criteria: * the patient is participating in another study * the patient is in an exclusion period determined by a previous study * the patient is under judicial protection, under tutorship or curatorship * the patient refuses to sign the consent * it is impossible to correctly inform the patient * patient cannot read french * patient is pregnant or breast feeding * patient has a fracture on an adjacent vertebra * patient has a contra-indication for a treatment used in this study * asa class iv or v * patient has a neurological deficit * previous spinal surgery
a new way for laparoscopic inguinal hernia repair in pediatric

Conditions: Complications of Surgical and Medical Care: General Terms

Summary: laparoscopic hernia sac high-ligation * has a high recurrence rate laparoscopic hernia sac high-ligation and the lateral umbilicus ligament covering the hernia opening * the investigators developed a method of laparoscopic hernia repair by applying a new concept in hernia repair. the hernia opening was tightened, and hernia opening region repaired with a lateral umbilicus ligament in a tension-free manner. this method combines the advantages of a secure repair achieved by the open method with the minimal invasiveness of the laparoscopic method. the investigators hypothesized that the lateral umbilicus ligament covering the internal hernia opening region after the laparoscopic purse-string knot would result in lower recurrence and the same operation relative complication.

the primary outcome measure was the recurrence rate after surgery, and the secondary outcome measures included degree of postoperative pain, the amount of postoperative analgesia, procedural duration, number of days to recovery normal activity, surgical complications, cosmetic results, and patient satisfaction. the outcome was recorded at the outpatient visits 10 days, 6 months, 1 year, 3 years and 5 years after the surgery. the cosmetic result was scored (unsatisfactory = 0, satisfactory = 1, good = 2, and excellent = 3) by the patients or parents, the attending nurse, and the surgeon (maximum points = 9). the patient satisfaction was scored similarly (unsatisfactory = 0, satisfactory = 1, good = 2, and excellent = 3). the long axis of the testes was measured.

Eligibility criteria:
inclusion criteria: * unilateral inguinal hernia age between 2 and 17 years the absence of a history of abdominal or inguinal operations. of the male patients, only those with completely descended testes were included. exclusion criteria: * the bilateral cases

Keywords: inguinal hernia lateral umbilicus ligament recurrence
detect and retinal outcomes in hypertension

Conditions: Hypertension; Retinal Disorder; Cognitive Impairment

Summary: the purpose of this study is to study the impact of blood pressure on cognitive performance.

four groups will be evaluated for possible impact of blood pressure on cognitive performance and retinal damage.

Eligibility criteria:
inclusion criteria: 1. patients triaged to the grady memorial hospital emergency department or marcus trauma unit 2. age \>18 and \<65 3. documented history of hypertension plus one or more of the following: * current antihypertensive use with controlled blood pressure * elevated emergency department systolic blood pressure or diastolic blood pressure * or - 4. acutely elevated emergency department systolic blood pressure or diastolic blood pressure on 2 separate emergency department measurements in the absence of a history of hypertension * or - 5. normal systolic blood pressure or diastolic blood pressure in the absence of hypertension. exclusion criteria: 1. non-english speaking 2. pre-visit cognitive impairment 3. physical or psychological impairments that would prohibit comprehension and completion of detect testing 4. inability to obtain adequate fundoscopic photos 5. acute intoxication, altered mental status, or head injury within the last 6 months 6. opiate or benzodiazepine administration by treating providers 7. clinical condition not allowing testing.

Keywords: hypertension retinal disorder cognitive impairment
enhancing fitness before pancreatic surgery

Conditions: Pancreatic Cancer; Pancreatitis, Chronic

Summary: this is a pilot study to investigate the effect of prehabilitation on patients undergoing elective surgery for pancreatic disease.

pancreatic surgery is high risk. the injury associated with surgery causes a stress response, comprising a variety of hormonal and metabolic effects. patients undergoing pancreatic surgery experience one of the largest stress responses. prehabilitation is the process of enhancing an individual's fitness, thereby improving tolerance to an upcoming physiological stress such as surgery. studies involving prehabilitation have been shown to improve recovery after surgery and reduce complication rates. there are currently no published reports of prehabilitation involving patients undergoing pancreatic surgery. this research study will explore the effect of prehabilitation in these patients. patients with pancreatic disease are some of the least fit surgical candidates due to the disease process. exercise training can improve physical fitness before elective abdominal surgery and nutritional supplementation can also influence clinical course via different mechanisms. patients with pancreatic disease are often malnourished for several reasons. we propose a multimodal approach to prehabilitation involving dietary and exercise interventions during a four-week period preceding elective surgery. core data will be collected from cardiopulmonary exercise tests and blood tests (to assess insulin sensitivity), before and after prehabilitation. secondary outcomes such as length of stay and complications will also be measured postoperatively.

Eligibility criteria:
inclusion criteria: elective pancreatic resection exclusion criteria: contraindication to cardiopulmonary exercise testing: unstable cardiac disease, lower limb dysfunction emergency surgery ischaemic ecg during cardiopulmonary exercise test allergy to fish oil or olive oil

Keywords: prehabilitation pancreatectomy nutrition exercise
nebulized 3% hypertonic saline in the treatment of acute bronchiolitis in the emergency department

Conditions: Acute Bronchiolitis

Summary: this is a prospective, randomized, controlled, double-blinded, clinical trial subject : 3mo \~ 24mo. aged infants with bronchiolitis the effect of 3 % nacl nebulizer or dexamethasone on admission rate of these infants in ed.

randomly assigned to one of three groups * group i : nebulized epinephrine + 0.9% saline + placebo * group ii : nebulized epinephrine + 3% saline + placebo * group iii : nebulized epinephrine + 0.9% saline + dexamethasone group i received two treatments of nebulized epinephrine mixed 0.9% saline and a total of six oral doses of placebo, group ii received nebulized epinephrine mixed 3% saline and oral placebo, and group iii received nebulized epinephrine mixed 0.9% saline and oral dexamethasone. the primary outcome is hospital admission within 7 days after the day of enrollment

Eligibility criteria:
inclusion criteria: * 3mo \~ 24mo aged patients with bronchiolitis visit to emergency departments * rdai score 4-15 exclusion criteria: * \ 24mo * infants who had received oral or inhaled corticosteroids during the preceding 2 weeks * infants with a previous episode of wheezing or a diagnosis of asthma * any chronic cardiopulmonary disease * immunodeficiency * infants needed intubation * infants with a previous history of apnea or intubation * infants with side effect of dexamethasone * infants born at less than 37 weeks of gestation who had a corrected age of less than 6 weeks at presentation

Keywords: hospital admission within 7 days of 3% nacl nebulizer vs dexamethasone
prevalence of pressure ulcers among critically ill patients and factors associated with their occurrence in the icu

Conditions: Pressure Ulcer; Critical Care; Intensive Care Unit Syndrome

Summary: the prevalence of and risk factors for pressure ulcers (pus) in critically ill patients have been poorly studied. the main objective of this study was to describe the prevalence of pus in critically ill patients. secondary objectives were to describe pus, means of prevention of pus, and factors associated with occurrence of pus in the icu.

pressure ulcers (pus) among hospitalized patients are associated with a poor prognosis and with a high cost of care. hospitalization in the icu is a context where there is a high risk of occurrence of pus, prevention of which is a priority for icu teams caring for critically ill patients. however, the literature is inconclusive regarding the prevalence of pus among critically ill patients and the associated risk factors. the main objective of this study was to describe the prevalence of pus among critically ill patients hospitalized in the icu. secondary objectives were to describe means of prevention of pus in the icu and the characteristics of pus, and to identify factors either related to the icu or patient characteristics associated with occurrence of pus in the icu.

Eligibility criteria:
the inclusion criteria were : * hospitalization in the icu * age ≥ 18 years. the exclusion criterion was: - refusal to participate in the study by the patient or by the patient's family when the patient was unable to consent.
digital 3d reconstruction predicts small bowel length

Conditions: Small Intestine Length Measurement

Summary: the prevalence of type 2 diabetes mellitus (t2dm) has been increasing annually worldwide, and the prevalence of diabetes has reached 11.6% in china. laparoscopic roux-en-y gastric bypass (rygb) is still widely accepted as a valid surgery in the treatment of obesity and t2dm. but still, there is no consensus on the ideal of the gastric bypass limb lengths. reported lengths of biliopancreatic limb (bpl) and alimentary limb (al) varied widely from 10-250 to 35-250 cm, and anatomical data show that the length of small intestine varies greatly among adults. choosing the same small bowel bypass length for different individuals obviously cannot achieve the expected weight loss effect, and individuals with too short small intestine can cause severe malnutrition complications and even life-threatening conditions. therefore, measurement of small bowel length is one of the prerequisites for performing precise rygb. intraoperative measurement of small bowel length can increase the operative time and the risk of surgical complications such as intestinal perforation. so, predicting the total length of the small intestine is very important for accurately performing bariatric surgery and avoiding the risk of surgical complications. in this study, we propose to perform 3d segmentation and reconstruction of the small intestine by acquiring abdominal ct data through digital technology, and predict the small intestine length by 3d digital measurement of the small intestine, and verify the digital measurement data by performing digital measurement data. establish a small bowel length prediction model for bariatric surgery to develop a more accurate and personalized gastric bypass surgery plan for patients to obtain weight loss and glucose control.


Eligibility criteria:
inclusion criteria: * patients eligible for surgical treatment of t2dm were selected based on the chinese guidelines for the surgical treatment of obesity and type 2 diabetes (2019 ) exclusion criteria: * adhesions, peritonitis, and patients who have had bowel resection (small intestine, colon or rectum) that hinder the measurement of the entire intestinal length * non-weight loss surgery patients whose incision is less than 6 cm are not suitable for measuring the length of the small intestine.

Keywords: bariatric surgery roux-en-y gastric bypass type 2 diabetes mellitus three-dimensional reconstruction
electrophysiological study of interindividual differences in speech-understanding among cochlear implant patients

Conditions: Hearing Loss

Summary: differences in speech-understanding and the quality of the subjective perception among cochlear implant patients (digisonic sp) depends on numerous factors. the electrical field distribution (interaction between electrodes) could also explain the disparity of the performances? the objective of our study was to quantify the influence of the electrical field interactions between the channels of stimulation according to the vocal performances of the implanted subjects, for various subjective levels of electric stimulation.


Eligibility criteria:
inclusion criteria: * subject of french language * subject with a moderate bilateral sensorineural hearing loss, severe to profound * sensorineural hearing loss post-lingual (after onset of language acquisition) * subject paired with the implant neurelec (appendix 1) for more than 9 months * subject has received an appropriate setting under usual clinical follow-up * elderly 18 to 75 years * subject giving consent exclusion criteria: * sensorineural hearing loss pre-lingual * deafness following a meningitis, or neurodegenerative diseases * illiteracy * pregnant women * subject blind * subject enjoying a measure of legal protection * subject incapable of giving consent * subject vulnerable

Keywords: subject with cochlear implant
community-based smoking cessation treatment for adults with high stress sensitivity.

Conditions: Nicotine Dependence

Summary: anxiety sensitivity, reflecting the fear of bodily sensations, is a risk factor for the maintenance and relapse of smoking. this study is designed to address the question - is a smoking cessation intervention personalized to high anxiety sensitive smokers and adapted for implementation by the ymca effective among racially/ethnically diverse samples?

this protocol provides the recommended treatment to achieve smoking cessation (i.e., counseling and nicotine replacement therapy) and randomly assigns individuals to a high-intensity exercise or low-intensity exercise intervention as a strategy to engage the mechanisms relevant to high anxiety sensitive smokers to improve smoking cessation outcomes.

Eligibility criteria:
inclusion criteria: * adult (age ≥ 18); * high anxiety sensitivity (≥5 on the short scale anxiety sensitivity index \[ssasi\]); * daily smoker, ≥5 cigarettes (including e-cigarettes, little cigars/cigarillos) for ≥1 year; * motivated to quit smoking as evidenced by a score of ≥5 on a 0-10 likert scale; * body mass index \&lt;40; * medical clearance to participate. * located near a participating ymca site (within 50 miles) exclusion criteria: * regular exercise defined as engaging in vigorous-intensity exercise for at least 75 minutes per week for the last 3 months * receiving current intervention for smoking cessation. * outstanding debt to the ymca * listed as a sex offender on the national sex offender registry
ivf versus surgery for endometriosis related infertility

Conditions: Endometriosis

Summary: the management of endometriosis-related infertility remains controversial. in particular, there is an equipoise for infertile women with endometriotic lesions detected at ultrasound. these women can be managed with either surgery or in vitro fertilization (ivf). the two approaches radically differ and they have never been compared with a randomized trial. as a consequence, affected women currently receive contrasting information and the mode of treatment substantially differ among centres, reflecting the local expertise of physicians rather than clinical needs. the present study aims at clarify whether ivf could be superior to surgery in infertile women with endometriotic lesions detected at ultrasound. this topic will be addressed comparing the two approaches in terms of effectiveness and cost-effectiveness. in addition, the study will disentangling whether the endometriosis-related systemic inflammatory mechanisms may have an impact on the quality of folliculogenesis and on ivf outcomes. this specific objective will be pursued through the characterization and analysis of circulating extracellular vesicles (ev)-immunologic, proteomic and mirna signatures and measurement of steroid hormones in follicular fluid.

women accepting to enter the study will be randomized to either surgery and then natural pregnancy seeking or a program of three complete ivf cycles (i.e. three oocytes retrievals regardless of the number of embryo transfers performed). the initial time point will be the time of randomization. women of both study groups will initiate treatment (surgery or ivf) in a shortest delay, maximum 3 months. only live birth pregnancies and initiating within a 12-months period starting from this time point will be included in the primary outcome.

Eligibility criteria:
inclusion criteria: * age \< 40 years * pregnancy seeking for more than 12 months * regular menstrual cycle, i.e. mean cycle interval between 21 and 35 days * ultrasonographic diagnosis of ovarian endometriomas or deep peritoneal endometriosis. * normal seminal analysis based on who criteria * absence of ureteral stenosis or intestinal subocclusive symptoms exclusion criteria: * previous surgery for endometriosis * previous ivf cycles * contraindication to pregnancy * hydrosalpinx * endometriomas with a mean diameter \> 4 cm * submucosal fibroids or large intramural or subserosal fibroids (≥ 5 cm). * doubtful sonographic findings that do not allow to reliably rule out malignancy. * obstacles to regular sexual intercourses (sexual disturbances or logistic problems)

Keywords: ivf surgery endometriosis
cervicothoracic junction mobilization versus eccentric muscle energy technique in mechanical cervical pain

Conditions: Neck Pain

Summary: 1. to compare the effectiveness of the cervicothoracic junction mobilization and eccentric muscle energy technique on mechanical cervical pain. 2. to compare the effectiveness of the cervicothoracic junction mobilization and eccentric muscle energy technique on cervical disability. 3. to compare the effectiveness of the cervicothoracic junction mobilization and eccentric muscle energy technique on cervical rom.


Eligibility criteria:
inclusion criteria: * participants falling in this category would be recruited into the study. 1. females 2. age between 18-45 years. 3. diagnosed with mechanical cervical pain. exclusion criteria: * participant failing to fall in this category would be excluded of the study. 1. pregnant females 2. any previous history of trauma or surgery 3. diagnosed with mechanical cervical pain due to disc herniation, radiculopathy or any other cervical malignancy.
improving work outcomes for veterans with traumatic brain injury

Conditions: Traumatic Brain Injury

Summary: the 12-month study will investigate a cognitive training augmentation of supported employment to improve cognitive performance and work outcomes, which are expected to result in improved quality of life and community integration for veterans with mild to moderate traumatic brain injuries. the primary hypothesis is that compared to veterans who receive enhanced supported employment, those who receive supported employment plus cognitive training will work more weeks during the 12 months.


Eligibility criteria:
inclusion criteria: * oef/oif veteran * history of mild-to-moderate tbi (loss of consciousness \<6 hours; post-traumatic amnesia \<7 days) * documented impairment in at least one neuropsychological domain * unemployed, but stating a goal of work * written informed consent to participate in the study exclusion criteria: * current alcohol/substance abuse or dependence * participation in other intervention studies

Keywords: vocational rehabilitation supported employment cognitive training cognitive remediation cognitive rehabilitation veterans