Kornimate/medical-research-clean huggingface dataset:
study of clinical, biological characteristics and quality of life of patients with hereditary or acquired non drug-induced bradykinin-mediated angioedema, monitored in besançon's partner site reference center for studies of kinin-mediated angioedema (creak)

Conditions: Angioedema

Summary: this study aims to describe quality of life in hereditary or acquired non drug-related bradykinin-mediated angioedema patients, using validated questionnaires


Eligibility criteria:
inclusion criteria: * clinically documented angioedema due to c1 inhibitor deficiency, hereditary (type i et ii) or acquired * clinically documented angioedema with normal c1 inhibitor activity (hereditary type iii) exclusion criteria: * acquired angioedema with normal c1 inhibitor activity (former "drug-induced") * minor subjects * vulnerable subjects (under guardianship/curatorship/tutorship) * pregnant women

Keywords: bradykinin-mediated angiodema quality of life
using different amplitude-modulated frequencies of ifc for the treatment of trigger points

Conditions: Trigger Point Pain

Summary: the authors of this work will conduct a randomized controlled trial intended to examine different amplitude-modulated frequencies of interferential current on different measures related to chronic trigger points located in the upper trapezius muscle.

this randomized controlled trial was designed to fill a gap in the literature regarding the most effective amplitude-modulated frequency of interferential current on pain pressure threshold, cervical rom, and function of the neck region. this study will be consisted of 4 groups, all groups will receive standard manual treatment commonly used for the treatment of chronic trigger points. this treatment will be conducted 3 times per week for 4 weeks. the standard treatment will consist of an intermittent neuromuscular inhibition technique. the 3 experimental groups will receive interferential current sessions (3/week) for 4 weeks with the same parameters except for the amplitude-modulated frequency. outcome measurements will be assessed at baseline, at 4 weeks, and at 4 weeks of the end of the treatment (follow-up).

Eligibility criteria:
inclusion criteria: * males or females, * 17 - 50 years of age, * unilateral pain in the cervical, neck, and upper shoulder, pain persists for 3 months or more, * pain should be not less than 2 on the visual analog scale (vas), * having positive signs of chronic (latent) trigger point(s) in the upper trapezius muscle exclusion criteria: * cervical and or shoulder pathologies such as disc lesions, arthritis, or compression problems. * neurological symptoms in the upper limb such as radiculopathy. * previous cervical, thoracic, or shoulder surgery. * regular sports practice. * heavy work-related activities. * trauma to the cervical spine (whiplash injury). * osteoporosis. * complex regional pain syndrome. * thoracic outlet syndrome * regular analgesic drugs.
the impact of respiratory training of dibh radiotherapy for breast cancer

Conditions: Breast Cancer

Summary: breast cancer dibh (deep inspiration breath hold) radiotherapy represents a high-precision treatment approach that substantially minimizes radiation exposure to vital organs such as the heart, thus enhancing protection of the patient's heart, lungs, contralateral breast, and other normal tissues compared to conventional radiotherapy techniques. this method requires meticulous precision, necessitating that patients possess exceptional respiratory control, which is facilitated through specialized equipment. without such control, patients may encounter issues like missed targets, significant setup errors, and extended treatment durations. in this study, the research team employed portable devices to enable patients to independently perform daily respiratory training exercises. the control group received no such devices; instead, these patients were merely instructed verbally on the importance of improving their breath-holding capabilities. the effectiveness of this intervention was evaluated by comparing the daily setup errors between the two groups. additionally, the intervention's influence on patient outcomes was assessed by monitoring the toxicity and side effects experienced by the patients.


Eligibility criteria:
inclusion criteria: * breast cancer radiotherapy patients * a single breath-hold can last for more than 10 seconds exclusion criteria: * a single breath-hold can last for more than 10 seconds
efficacy of lumiracoxib in relieving moderate to severe post-dental surgery pain, compared to both placebo and celecoxib

Conditions: Pain

Summary: this study will assess the safety and efficacy of lumiracoxib 400 mg in relieving moderate to severe post-dental surgery pain, compared to both placebo and celecoxib 400 mg.


Eligibility criteria:
inclusion criteria: * requiring extraction of two or more partially impacted or fully bony impacted third molars. at least one of the extractions must be mandibular * moderate to severe post-dental surgery pain intensity (as rated by the patient on the categorical pain intensity scale within five hours of surgery exclusion criteria: * evidence or history of any cardiac and cerebral thrombotic/ ischemic diseases and/ or events other protocol-defined inclusion/exclusion criteria may apply

Keywords: dental surgery acute pain lumiracoxib celecoxib moderate to severe pain following dental surgery
deep brain stimulation (dbs) frequency effects on gait in parkinson's disease(pd)

Conditions: Parkinson Disease

Summary: in this study the investigators will evaluate the effect of both low and high frequency deep brain stimulation of the subthalamic nucleus (stn) in parkinson's patients who have noted a change in their walking. the investigators' hypothesis is: 1. stimulation at 60 hertz (hz) is associated with improved gait with increased stride length and faster time on the stand walk sit test. 2. there is no worsening of the unified parkinson's disease rating scale (updrs) at 60 hz.


Eligibility criteria:
inclusion criteria: * be a patient at the vanderbilt movement disorders clinic. * report a change in their gait. * be able to walk independently when off pd medications for 12-16 hours. * have a stable dose of pd medications for the prior three months . * not cognitively impaired, so as to give informed consent. * mmse \> 24. exclusion criteria: * see inclusion criteria.

Keywords: parkinson's disease dbs frequency deep brain stimulation
emerge mothers and kids

Conditions: Gestational Diabetes

Summary: the emerge mothers and kids study is a follow-up to the emerge trial of women with gdm (n=535) that aimed to determine the effect of the addition of metformin compared to placebo on insulin initiation rates, maternal weight gain and perinatal morbidity and mortality. the primary objectives of the emerge mothers and kids follow up study are: 1. to determine whether treatment with metformin leads to a reduction in maternal disorders of glucose, metabolic syndrome, obesity, hypertension and lipids at up to 10 years post the index pregnancy; 2. to examine the impact of metformin on maternal anxiety, depression, quality of life and breast feeding duration; 3. to examine whether exposure to metformin leads to a reduction in obesity in the offspring at follow up; 4. to determine whether treatment with metformin during pregnancy, in women with gdm, leads to a reduction in adiposity in the offspring at follow up as measured by anthropometric measurements and sum of skinfolds.


Eligibility criteria:
inclusion criteria: * participation in the original emerge trial and consenting to further follow up. exclusion criteria: * emerge trial participants who did not provide consent for further follow up studies.
blood test for early detection of breast cancer using todos medical -breast 1(tm-b1) assay

Conditions: Breast Cancer

Summary: blood samples from a total of 200 women in two cohorts will be collected and analyzed by tm-b1 assay, which is based on tbia (total biochemical infrared analysis) to confirm the presence of cancer. these two cohorts will yield 75 healthy women with no pathological findings, 75 women diagnosed as having benign breast tumor and 50 women diagnosed as having breast cancer.

prospective, two arms, observational, blinded, cohort study enrolling 200 women which intended to validate the cut-off points between women with malignant tumors, benign tumors, and women without tumors (controls) and to validate the sensitivity and specificity of tm-b1 for the detection of an invasive breast tumor. two cohorts will be tested with tm-b1. the cohorts will differ in the percentage of women that are expected to yield a positive finding for breast cancer. any finding in tm-b1 will not influence medical standards of care.

Eligibility criteria:
inclusion criteria: screening population: * subject signed the informed consent. * subject is aged 25 years and older. * subject is presenting for routine screening or diagnostic xrm and / or breast us. breast cancer population * subject signed the informed consent form. * subject is aged 25 years and older. * subject was diagnosed with a malignant breast tumor, and has not yet started treatment. exclusion criteria: all subjects: * subject has been diagnosed with any type of malignancy apart from breast cancer. * subject has been previously treated for breast cancer. * subject underwent any surgery within the previous year (apart from benign nevus removal). * subject was treated for benign tumor within the previous year (e.g. polyps or cysts). * subject has an active infection or inflammation from any type of infection (bacterial or viral) as determined clinically at screening. * subject is currently taking medications related directly to, or that can affect, the immune system such as steroids. * subject has any type of active autoimmune disease such as lupus or rheumatoid arthritis. * diagnostic drugs (e.g. contrast materials) were injected or given orally to subject within the last 7 days prior to sample collection for tm-b1 analysis. * subject has been taking any investigational drug which influence her health status within 30 days prior to sample collection for tm-b1 analysis. * subject is not feeling well at the time of blood collection for tm-b1 analysis due to suspected bacterial or viral infection or subject has symptoms such as high fever, diarrhea, headache, vomiting, dizziness etc. * subject is pregnant, lactating, or undergoing fertility treatment. * subject has participated in this study, in another cohort, and the tm-b1 test was performed. breast cancer population only: * the subject's tumor has been surgically removed before sample collection for tm-b1 analysis.
mobile instant messaging-based lifestyle intervention for gestational diabetes prevention

Conditions: Gestational Diabetes

Summary: the goal of this randomised controlled trial is to test the effectiveness of a mobile instant messaging-based lifestyle intervention in pregnant women at risk of gestational diabetes

gestational diabetes mellitus (gdm) is one of the most common medical conditions during pregnancy, affecting about 1 in 7 live births worldwide. there remains a lack of proven preventive strategies for gdm that could be readily adopted in clinical practice. recent studies have suggested that lifestyle intervention delivered via mobile phone could help pregnant women prevent gdm, but more evidence is needed. this study aims to test a mobile instant messaging-based lifestyle intervention for gdm prevention in pregnant women at risk of gdm.

Eligibility criteria:
inclusion criteria: 1. ethnic chinese singleton pregnant woman in \<14 weeks of gestation 2. aged 18 years or above 3. own a mobile phone with an instant messaging app 4. not participating in similar trials on diabetes or lifestyle modifications 5. have at least one of the following risk factors for gdm: * age ≥35 years at the expected date of delivery * body mass index (bmi) ≥ 25 kg/m2 pre-pregnancy or in the first trimester * family history of diabetes in first-degree relative * previous gdm or delivered a baby with birthweight ≥4 kg exclusion criteria: * pre-existing diabetes or other medical conditions that may affect metabolism (e.g., thyroid disorders) or psychiatric disorders

Keywords: lifestyle modification gestational weight gain chinese digital health mhealth whatsapp
a new method for deltoid ruptures: gap sign

Conditions: Ankle Fractures; Ligament Rupture; Ligament Injury

Summary: "deltoid gap sign" which would be a new method of examination for deltoid ligament injuries will be investigated. it will be analyzed if it is correlated with the external rotation stress test. the study is designed as a blinded, comparative and prospective trial.

ankle fracture patients who applied to our clinic agreed to be included in the study and underwent surgical intervention will participate in the study. the pediatric age group will not be included in the study, since deltoid ligament tears are not common in ankle fractures in pediatric age. however, since this fracture can also be seen in pregnant women, if there is a pregnant patient who will require surgical treatment, they can be included in the study. "deltoid gap sign" which is the main subject of this study, will be performed in patients firstly at patients' ward i) without pre-operative anesthesia, secondly at operating theatre ii) under anesthesia before the operation. the examination will be carried out by two different physicians and the opinion of both physicians will be noted. physicians will be blinded and will not know others' decisions. external rotation stress test (erst) in dorsiflexion, which is another examination method accepted in the literature in the evaluation of the deltoid ligament, will also be performed by two physicians and the opinions of the physicians will be noted. erst will be analyzed under fluoroscopy control. after the examination, open surgery will be performed around the medial malleolus. it will be noted whether the deltoid ligament was injured (ruptured/ not ruptured), which fibers of the deltoid ligament (superficial/deep/superficial + deep fibers) were ruptured. statistical ratios such as positive predictive value, negative predictive value, sensitivity, specificity, and likelihood ratio will be calculated based on the results obtained. deltoid gap sign will be checked whether it is correlated with erst and the results will be compared with the erst.

Eligibility criteria:
inclusion criteria: * patients who had operated on because of ankle trauma * patients who had been performed an open surgery at the medial malleolus region * patients with maisonneuve fractures exclusion criteria: * medial malleolus fractures * talus fractures * patients in pediatric age
application of tms coupled with vr for slowing the rate of cognitive decline in patients with alzheimer's disease

Conditions: Alzheimer Disease

Summary: this is a randomized sham control study to evaluate how repetitive transcranial magnetic stimulation (rtms), interactive cognitive training, or the combination of rtms and cognitive training reduce the cognitive decline of patients diagnosed with alzheimer's disease

participants may be assigned to one of four experimental arms (1-tms-stimulation with x-torp task, 2-tms-stimulation with mindmotion go, 3-tms-sham with x-torp task, 4-tms-sham with mindmotion go.) the study will be conducted in two phases. during phase 1, participants will be randomized between experimental conditions 1 and 4. data will be analyzed upon completion of phase1 and phase 2 will commence only if there is efficacy in the tms arm. during phase2, participants will be randomized to arms 2 and 3.

Eligibility criteria:
inclusion criteria: male or female between 50-85 years of age * able and willing to give informed consent * probable ad consistent with nia/aa criteria * modified hachinski ischemia scale (mhis) score of \<= 4 * geriatric depression scale (gds) score of \<= 6 * mini mental state exam (mmse) score 18-26. the mmse adjusted scoring instructions may be followed for screening patients as applicable. exclusion criteria: * unstable medical conditions * visual impairments * mobility limitations * cognition-enhancing medication unless on a stable dosage for at least 3 months before the start of the trial. * history of epilepsy or seizure disorder * history of psychosis * current thoughts of suicidal ideation or self-harm as assessed by the columbia-suicide severity rating scale score * progressive neurological disorder or focal signs of abnormality on neurological exam as conducted by a neurologist (other than current diagnosis of ad) * tinnitus * metal implants (excluding dental fillings) * possible pregnancy * substance use disorder within the past six months * have other mental or physical conditions that are inappropriate for study participation at pi's or delegated sub investigator's discretion. * intake of one or a combination of the drugs that may due to their significant seizure threshold lowering potential
treatment outcome with a revascularization protocol using the triple versus double antibiotic paste

Conditions: Pulp Necrosis

Summary: the purpose of this study is to determine the treatment outcomes in permanent teeth with necrotic pulp and immature root development that undergo a regenerative procedure using a triple antibiotic paste (ciprofloxacin, metronidazole, minocycline) versus a double antibiotic paste (ciprofloxacin, metronidazole)compared to the commonly used mineral trioxide aggregate (mta) apexification treatment.

recent case series have reported positive outcomes treating necrotic immature permanent teeth with a regenerative procedure using a triple antibiotic paste (ciprofloxacin, metronidazole, minocycline). however, this method can result in considerable staining due to minocycline. in this randomized clinical trial, we will compare clinical outcomes of a triple antibiotic paste versus a double antibiotic paste (ciprofloxacin, metronidazole) intracanal medicament as compared to a standard treatment (immediate apexification with mta) in permanent teeth with necrotic pulps and immature root development. we hypothesize there will be no significant differences between radiographic measures of root development after treatment with either the double versus triple antibiotic paste, and that both methods will produce significantly greater increases in root length and width compared to standard treatment. the primary outcome measures will be radiographic measurement of root length and dentinal wall thickness and the secondary outcomes will be lack of clinical symptoms and crown staining.

Eligibility criteria:
inclusion criteria: * diagnosis of pulpal necrosis with apical periodontitis * patients 7-60 years of age * maxillary or mandibular restorable single rooted immature permanent tooth with open apices * acceptance of treatment plan with revascularization procedure * healthy patient (asa class i or ii physical status) with no systemic health problems exclusion criteria: * non-restorable teeth * patients with asa class iii or iv physical status (immuno-compromised patients including patients who self-report to be a carrier of hiv, undergoing steroid therapy, or those who self-report with genetic or systemic diseases that could result in reduced immune response. * child subjects unable to give assent

Keywords: regeneration (revascularization) of dental pulp immature permanent tooth with a diagnosis of
cbt versus a return to work intervention for patients with common mental illness in primary care

Conditions: Anxiety Disorders; Major Depression; Stress Disorders; Primary Insomnia

Summary: background: common mental illness, such as anxiety disorders and depression, is the main cause for sick leave in sweden. cognitive behavior therapy (cbt) has been shown to be effective in alleviating target symptoms of these disorders, but its effect on sick leave rates has not been sufficiently addressed. the investigators have developed an intervention called return to work (rtw), which is based in cognitive behavioral theory, that has a primary aim of helping sick-listed patients with common mental illness return to work. this new treatment has not been evaluated in a randomized controlled trial. aims: the aim of this study is to investigate the effect of cbt and rtw for common mental illness in a randomized controlled trial conducted in primary care. participants will be randomized to diagnosis specific cbt (n=70), rtw (n=70), or a combination of the two treatments (n=70). main outcomes are days of sick leave and clinician severity rating of psychiatric symptoms. this study could contribute to new knowledge regarding how to best treat patients on sick leave with common mental illness.


Eligibility criteria:
inclusion criteria: * have been on sick leave (at least 50%) for at least 1 month and not more than 6 months * have an anxiety disorder diagnosis (obsessive compulsive disorder, social phobia, panic disorder, generalized anxiety disorder, post-traumatic stress disorder, specific phobia), or/and major depression, or/and maladaptive stress reaction, or/and primary insomnia exclusion criteria: * a lower score than 4 on the clinician severity rating scale * a higher score than 6 on the clinician severity rating scale