Kornimate/medical-research-clean huggingface dataset:
long-term outcome of pediatric traumatic wound repair: suture versus tissue adhesive

Conditions: Tissue Adhesives; Laceration; Sutures; Wounds and Injuries; Child

Summary: this project is an observational trial investigating wound cosmetic appearance after repair of traumatic skin lacerations in the head area of pediatric patients with two different approaches to skin closure: sutures versus tissue adhesive. photographs will be taken at two follow-up visits after repair and later assessed by external blinded plastic surgeon using standard cosmetic assessment scales. the investigators hypothesize that cosmetic wound outcome will be equivalent in these two wound repair treatment options.

investigation of the long-term outcome of 300 pediatric patients with traumatic skin lacerations in the head area. after primary wound repair with suture or with tissue adhesive, eligible patients will be enrolled on the emergency department (baseline visit). the second follow-up visit will take place 5-10 days after the baseline visit and the third follow-up visit will be completed 6-12 months after trauma. at both follow-up visits, clinical examination and a brief interview will be performed. photo documentation is completed at both the baseline and the follow-up visit. encrypted photo documentation will be evaluated by blinded external plastic surgeons. primary outcome is the cosmetic appearance using standard assessment scales, secondary outcomes are the occurrence of complications, cost-effectiveness and patient's satisfaction.

Eligibility criteria:
inclusion criteria: * 0 till16 years of age * any primary wound repair treatment of a laceration caused by trauma and involving the skin of the head area * patient or caregiver must be able to understand and sign an informed consent exclusion criteria: * pre-existing conditions that affect wound healing adversely * patients who demonstrate severe or life-threatening injuries * patients / caregivers with communication / logistic barriers that would make them unfit to provide informed consent or to attend the follow-up visits

Keywords: trauma laceration suture cosmesis ethyl-2-cyanoacrylate tissue adhesive lip lacerations skalp lacerations facial injuries
pharmacoinvasive therapy with prourokinase

Conditions: ST-segment Elevation Myocardial Infarction (STEMI)

Summary: the aim of this study is to elucidate the efficacy and safety of pharmacoinvasive therapy by using prourokinase (prouk), a unique fibrin-specific agent, in patients with st-segment elevation myocardial infarction (stemi)


Eligibility criteria:
inclusion criteria: * age 75 years or younger, symptom onset 6 h or less before randomization, intention to undertake primary pci, st-segment elevation of 2 mm or more in two anterior leads or of 1 mm or more in two inferior leads if they had st-segment elevation, or new left bundle-branch block. exclusion criteria: * expected arrival at the catheterization laboratory less than 1 h or more than 3 h after randomization, anticipated problems with vascular access, previous enrollment to other studies, and the usual contraindications to thrombolytic therapy.
the prevention of contrast induced nephropathy by sarpogrelate in patients with chronic kidney disease

Conditions: Chronic Kidney Disease

Summary: background: contrast-induced nephropathy (cin) is a serious clinical problem associated with increased morbidity and mortality, particularly in patients with chronic renal insufficiency. although some agents including hydration with saline are being prescribed to prevent renal deterioration in these high risk patients, their efficacy is not clear defined and debatable. therefore additional prophylactic pretreatments are needed. methods/design: present study aims to investigate differences in occurrence of cin after sarpogrelate premedication in patients with chronic kidney disease (ckd). 268 participants, aged 20-85 years with a clinical diagnosis of ckd will be recruited. they will be randomly allocated to one of two conditions: (i) a routine treatment without sarpogrelate group (ii) routine treatment with sarpogrelate (a fixed-flexible dose of 300 mg/day). the primary outcome is the occurrence of cin during 4 weeks after receiving contrast agent. discussion: as of may 2010, there were no registered trials evaluating the therapeutic potentials of sarpogrelate in preventing for cin. if sarpogrelate decreases the worsening of renal function and occurrence of cin, it will provide a safe, easy and inexpensive treatment option.

all patients with ckd scheduled for cag will be eligible, assuming their ability to understand the character and individual consequences of participation as well as giving written informed consent. ckd is defined as estimated glomerular filtration rate (egfr) \ 1.5 mg/dl. the mdrd formula was defined in the following way. where the cr concentration is in mg/dl: egfr = 186 × serum cr-1.154 × age-0.203 × (0.742 if female) exclusion criteria are age less than 20 years or more than 85 years, liver cirrhosis greater than or equal to child class b, decreased serum platelet level (\< 100,000/ul), patients who received or are schedule to receive percutaneous renal intervention, currently are taking anticoagulation drugs, unable to give informed consent. patients in shock, maintaining hemodialysis, hemofiltration, peritoneal dialysis will be excluded.

Eligibility criteria:
inclusion criteria: * patient with chronic kidney disease scheduled for coronary angiogram exclusion criteria: * age less than 20 years or more than 85 years * liver cirrhosis greater than or equal to child class b * decreased serum platelet level (\< 100,000/ul) * patients who received or are schedule to receive percutaneous renal intervention * currently are taking anticoagulation drugs * unable to give informed consent
effects of receptive music therapy combined with virtual reality on prevalent symptoms in patients with advanced cancer

Conditions: Music Therapy

Summary: the present research seeks to determine whether a single responsive music therapy intervention combined with virtual reality (rmt+vr) reduces prevalent symptoms and improves their overall well-being in hospitalized adult patients with advanced oncologic disease receiving palliative care. this is a prospective study of a randomized clinical trial with a control group. the main variables are pain, exhaustion, drowsiness, nausea, loss of appetite, dyspnea, depression, anxiety, sleep and well-being as well as heart rate.

music therapy has been shown to be effective in hospitalized patients, reducing the level of stress and anxiety, lowering tension, regulating breathing and relieving pain. however, despite the fact that there are many precedents of this type in palliative care, the quality of the evidence is low. the present research seeks to determine whether a single responsive music therapy intervention combined with virtual reality (rmt+vr) reduces prevalent symptoms and improves their overall well-being in hospitalized adult patients with advanced oncologic disease receiving palliative care. this is a prospective study of a randomized clinical trial with a control group. the main variables are pain, exhaustion, drowsiness, nausea, loss of appetite, dyspnea, depression, anxiety, sleep and well-being as well as heart rate. the duration of the study will be 48 hours. after signing the informed consent, patients will be randomized on the first day receiving rmt+vr, or no intervention at all. the variables will be measured on three occasions, before and after each condition, and 24 hours later.

Eligibility criteria:
inclusion criteria: * all of them are treated by the palliative care unit of the austral university hospital. * individuals ≥ 18 years of age with advanced cancer defined from the use of the necpal-ccoms instrument * they can be hospitalized in the medical clinic service (auh) or in the integral care unit (icua) within the hospital, and must sign the informed consent after being duly explained by the principal investigator. * likewise, they must have a minimum previous esas-r of at least 7 points in a symptom, * they must be able to adopt a posture of at least 45º in bed and a state of alertness and adequate response. exclusion criteria: * they should not present cognitive impairment (measured by pfeiffer scale \[21\] \> 2 errors) * have functional hearing (with or without hearing aids or other devices).

Keywords: virtual reality paliative care anxiety emotional distress advanced cancer prevalent symptoms
effect of sorting of apoptotic spermatozoa on the outcome of assisted reproduction

Conditions: Male Infertility

Summary: in assisted reproductive technology (art) semen needs to be processed. commonly used methods rely on physical properties of the spermatozoa, such as the swim-up methods and density gradient centrifugation. it is now known that current processing of spermatozoa does not prevent the admixture of spermatozoa with damaged genetic material. the latter have a negative impact on the outcome of art. the investigators developed a new method for the processing of spermatozoa with intact genetic material based on flow cytometry and sorting (facs) and on staining using a deye, yopro. the investigators aim at examining the effect of this novel method of sperm sorting on the outcome of art.


Eligibility criteria:
inclusion criteria: * infertile couples needing treatment with icsi * male infertility as defined by the who 2010 criteria * age of the treated women should be between 22 and 39 years of age. * normal ovarian reserve, as defined by basal fsh-concentration below 10 iu/l and amh-concentration above 10 pmol/l. * signed consent form. exclusion criteria: * normal male infertility, as defined by the who 2010 criteria * age of the treated women below 22 years and above 39 years * reduced ovarian reserve, as defined by an elevated basal fsh-concentration or reduced amh-concentration. * not more than two preceding unsuccessfull treatments with icsi * severe disease of the male or female partner, such as hiv, hepatitis, or psychiatric illness. * participation in another study. * lack of a signed consent form.

Keywords: intracytoplasmic sperm injection male infertility apoptosis flow cytometry and sorting dna fragmentation
moderate alcohol consumption, fat and carbohydrate metabolism and insulin sensitivity

Conditions: Diabetes Mellitus, Type 2; Cardiovascular Disease

Summary: moderate alcohol consumption is associated with a decreased risk of diabetes type 2. this association could be mediated by an improvement of insulin sensitivity with moderate alcohol consumption. patients with diabetes type 2 or impaired glucose tolerance often may have decreased fat oxidative capacity or oxidative phosphorylation in tissue such as muscle. this could lead to accumulation triglyceride storage in muscle, which could interfere with insulin signaling. whether such mechanism can also play a role with moderate alcohol consumption is unknown and will be investigated in this study. in addition, moderate alcohol consumption with a meal can lead to delayed hypoglycemia in type 1 diabetes patients. how moderate alcohol consumption affects postprandial glycemic response in healthy subjects is unknown. this is a secondary objective of this trial.

to investigate the effect of moderate alcohol consumption on * enzymes involved in fatty acid oxidation, oxidative phosphorylation and glycolysis in skeletal muscle * transporters of fatty acids and glucose in fat tissue * post-prandial glycemic response in healthy, lean or overweight, young men design : open, randomized, partially diet-controlled, placebo controlled cross-over design participants * description : healthy, lean and overweight young (18-40 years) men * number : 20 study substances * test substance : 100 ml whiskey (famous grouse, 40% v/v alcohol: ≈ 32 g alcohol) * reference substance : 100 ml mineral water (spa blauw) duration: 2 treatment periods of 4 weeks (28 days) test parameters: * muscle biopsy for activity of 3-hydroxy fatty-acyl coa dehydrogenase, citrate synthase, cytochrome c oxidase * postprandial glycemic response (glucose, insulin, glp-1, glp-2, gip, glucagon, ffa etc.) * insulin sensitivity and related factors (oral glucose tolerance test, adiponectin, hba1c) * liver enzymes (safety) * body weight * urinary ethyl glucuronide (compliance)

Eligibility criteria:
inclusion criteria: * healthy men aged between 18 and 40 years * lean subjects bmi 18.5-25 kg/m2 and overweight/obese subjects bmi \>27 kg/m2 (including 18.5, 25 and 27) * alcohol consumption between 7 and 28 units/week (including 7 and 28) exclusion criteria: * smoking * family history of alcoholism * history of medical or surgical events that may significantly affect the study outcome, particularly metabolic or endocrine disorders and gastrointestinal disorders * recent blood donation * more than 8 hours/week of intense exercise * blood haemoglobin concentration below 8.4 mmol/l * allergic to betadine or lidocaine.

Keywords: moderate alcohol consumption fat and carbohydrate oxidative capacity postprandial glycemic response
the impact of an immersive digital therapeutic tool on pain perception

Conditions: Pain Perception

Summary: the goal of this experimental study is to examine the impact of a virtual reality paradigm on heat pain perception in healthy volunteers. the main question it aims to answer is to determine if the virtual reality paradigm reduces pain intensity and unpleasantness evoked by tonic heat pain stimulation. tonic heat pain stimulation is applied on the left forearm of participants using a peltier thermode immediately before, during and immediately after virtual reality exposure. using a with-subject design, participants are sequentially exposed to both the virtual reality condition and an active control condition. the order of administration of the virtual reality and control conditions is randomized.

pain is a complex and multifaced sensory and emotional experience. virtual reality has shown promise in reducing experimental pain and chronic pain. however, many previous trials in the field lacked proper control conditions. this experimental study examines an immersive virtual environment initially designed for the treatment of endometriosis patients, which demonstrated promising analgesic effects. the current study aims to determine the impact of the virtual reality paradigm on experimental pain perception both during and after virtual reality exposure, while using an active control condition. this study involves healthy individuals with no chronic pain and uses a within-subject design, comparing a virtual reality paradigm with an active control condition. continuous heat pain stimulation is applied to the left forearm of participants with a peltier thermode, before, during and immediately after virtual reality exposure. for each continuous heat pain stimulation, pain intensity and unpleasantness are measured using a scale from 0 (no pain) to 100 (worst pain). using a with-subject design, participants are sequentially exposed to both the virtual reality condition and an active control condition. the order of administration of the virtual reality and control conditions is randomized. both conditions are administered in a single experimental session at the laboratory.

Eligibility criteria:
inclusion criteria: * healthy men and women * between 18 and 50 years old * willing to participate in the study * able to sign the informed consent form exclusion criteria: * neurological disorders * substance use disorders * severe mental health disorder * chronic pain * any acute and unstable medical condition * taking medication that acts on the central nervous system

Keywords: pain emotions virtual reality within-subject design
multicomponent exercise in the functionality of the elderly in the community

Conditions: Aging; Cognition; Balance; Mobility Limitation

Summary: evaluate the results of the implementation of a multicomponent exercise program (16 weeks) for elder community dwelling population on their functionality (via cognitive, balance and mobility status).

a quasi-experimental study, of the pre-test-post-test type, with a sample for convenience from in a cohort of elderly community dwelling people, carried out between 2009 and 2011. the general objective is to verify the impact of a physical exercise program organized in classes, under the supervision of physiotherapists.the specific objectives are to analyze the effect after 8 and 16 weeks, on the functionality of the elderly person, discriminating three conditions: cognitive state, balance and functional mobility.

Eligibility criteria:
inclusion criteria: * be supported by day centers or collective residences linked to the "project + city", * not having regular exercise habits, * ability to walk (with or without assistance). exclusion criteria: * not being collaborative, * missing the classes three times.

Keywords: aging community exercise program physiotherapy functionality
effect of transcutaneous auricular neurostimulation on cognitive performance in a laboratory model of acute stress reaction

Conditions: Acute Stress Reaction; Cognitive Performance

Summary: the objective of this study is to test the effects of transcutaneous auricular neurostimulation (tan) in treating or preventing performance degradation after an acute stressor.

this study is designed as a randomized, double-blind, sham-controlled trial. sixty healthy, able-bodied participants will be randomized 1:1:2:2 into one of four experimental groups: group 1: active tan for prophylactic treatment prior to acute stress exposure (n=10) group 2: sham stimulation for prophylactic treatment prior to acute stress exposure (n=10) group 3: active tan for acute treatment during acute stress exposure (n=20) group 4: sham stimulation for acute treatment during acute stress exposure (n=20) participants will complete a baseline performance of three tasks. tan treatment will then be administered prior to or during an acute stress test. participants will complete the same three tasks preformed at baseline. in addition to the tan therapy earpiece, subjects will have biosensors attached to them to collect biomarker information.

Eligibility criteria:
inclusion criteria: 1. adults 18 to 41 years old 2. participant has the cognitive and physical abilities to carry out the study tasks 3. proficient in the english language 4. ability to understand the explanations and instructions given by the study personnel exclusion criteria: 1. participant presents current evidence of an uncontrolled and/or clinically significant medical condition or psychiatric condition 2. participant has used any psychological stress-management intervention within the last 4 weeks 3. participant is participating in another interventional trial within 90 days prior to or throughout duration of trial 4. participant has a prior diagnosis of post-traumatic stress disorder, acute stress disorder, or generalized anxiety disorder 5. participant is currently using anti-anxiety medications such as xanax or beta blockers 6. participant has a diagnosis of attention deficit hyperactivity disorder (adhd) and/or is currently taking medications for the treatment of adhd. 7. history of substance abuse or drug dependence including nicotine and alcohol in the past 3 months 8. participant has abnormal ear anatomy, ear infection present, or earpiercing that could interfere with stimulation 9. participant has a history of epileptic seizures 10. participant has a history of neurologic diseases or traumatic brain injury 11. participant wears or utilized other devices that cannot be removed during the study (e.g., pacemakers, cochlear prostheses, neurostimulators) 12. females who are pregnant or lactating 13. participant has any other significant disease or disorder which, in the opinion of the investigator, may either put the participants are risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial

Keywords: healthy human performance stress vagus nerve stimulation neurostimulation transcutaneous auricular neurostimulation military
acute myocardial infarction study in northeastern china

Conditions: Acute Myocardial Infarction

Summary: this is a real-world prospective cohort study aiming to generate knowledge about the characteristics, treatments, and outcomes of hospitalized ami patients in jilin province. the study includes hospitalizations diagnosed of ami, including st segment-elevation myocardial infarction (stemi) and non-st-segment-elevation myocardial infarction (nstemi).


Eligibility criteria:
inclusion criteria: * patients admitted within 7 days of acute myocardial ischemic symptoms with a primary clinical diagnosis of ami, meet fourth universal definition for myocardial infarction (2018) exclusion criteria: * types 4a and type 5 ami
restrictive versus liberal oxygen strategy and its effect on pulmonary hypertension after out-of-hospital cardiac arrest (relieph-study)

Conditions: Hypertension, Pulmonary Arterial; Out-Of-Hospital Cardiac Arrest; Intensive Care Unit; Oxygen Therapy; Mechanical Ventilation; Resuscitation

Summary: background: for patients with out-of-hospital cardiac arrest (ohca) at the intensive care unit (icu), oxygen therapy plays an important role in post resuscitation care. during hospitalisation, a lot of these patients occur with pulmonary arterial hypertension (pah). currently a wide oxygen target is recommended but no evidence regarding optimal treatment targets to minimise the prevalence of pah exists. methods: the relieph trial is a substudy within the box (blood pressure and oxygenation targets in post resuscitation care) trial. it is a single-center, parallel-group randomised controlled clinical trial. 300 patients with ohca hospitalised at the icu are allocated to one of the two oxygenation interventions, either a restrictive- (9-10 kpa) or liberal (13-14 kpa) oxygen target both within the recommended range. the primary outcome is the fraction of time with pulmonary hypertension (mpap \>25 mmhg) out of total time with mechanical ventilation. secondary outcomes are: length of icu stay among survivors, lactate clearance, right ventricular failure, 30 days mortality and plasma brain natriuretic peptide (bnp) level 48 hours from randomisation. discussion: this study hypothesises that a liberal target of oxygen reduces the time with pah during mechanical ventilation compared to a restrictive oxygen target in patients with ohca at the icu. when completed, this study hopes to provide new knowledge regarding which oxygen target is beneficial for this group of patients.


Eligibility criteria:
inclusion criteria: * age ≥18 years * ohca of presumed cardiac cause * sustained rosc * unconsciousness (glasgow coma scale \<8) after sustained rosc exclusion criteria: * conscious patients (obeying verbal commands) * females of childbearing potential (unless a negative hcg test can rule out pregnancy within the inclusion window) * in-hospital cardiac arrest * ohca of presumed non-cardiac cause e.g. after trauma or dissection/rupture of major artery or cardiac arrest caused by initial hypoxia (i.e. drowning, suffocation, hanging). * known bleeding diathesis (medically induced coagulopathy (e.g. warfarin, noac, clopidogrel) does not exclude the patient) * suspected or confirmed acute intracranial bleeding * suspected or confirmed acute stroke * unwitnessed asystole * known limitations in therapy and do not resuscitate-order * known disease making 180 days survival unlikely * known pre-arrest cerebral performance category 3 or 4 * \>4 hours (240 minutes) from rosc to screening * systolic blood pressure \<80 mmhg in spite of fluid loading/vasopressor and/or inotropic medication/intra-aortic balloon pump/axial flow device * temperature on admission \<30°c

Keywords: out-of-hospital cardiac arrest resuscitation oxygen intensive care unit mechanical ventilation pulmonary hypertension