Kornimate/medical-research-clean huggingface dataset:
molecular phenotyping of migraine patients according to sex and age through cgrp quantification

Conditions: Headache (Migraine); Migraine; Migraine Headache; Migraine with Aura; Migraine Without Aura; Episodic Migraine; Chronic Migraine Headache; Chronic Migraine, Headache; Episodic Migraine Headache

Summary: patients will be asked to visit the study center 2 times, the first time for clinical assessment and a second time for sample collection. healthy controls will only be asked to visit the study center for sample collection. a sample of blood and saliva will be collected in order to measure cgrp levels and dna and hormone testing.

cgrp is a neuropeptide related to migraine pathophysiology, which can be found in human saliva in both patients and healthy controls. the differences in cgrp levels may help us explain the differences in the treatment response. a sample of saliva will be collected in order to measure cgrp levels and a blood sample will be collected in order to conduct a dna test and hormones test.

Eligibility criteria:
inclusion criteria: * migraine patients according to ichd-3 criteria * healthy controls paired to patient age and sex, without headache and without first degree family history of headache. exclusion criteria: * presence of any major medical or neurological illness. * presence of any salivary gland malfunction. * abuse or dependence to tobacco, alcohol or any drug in the previous 12 months before the enrollment. * active migraine preventive treatment. * pregnant or breastfeeding female.

Keywords: migraine cgrp saliva
comparison of hyaluronic acid and platelet-rich plasma injections

Conditions: Knee Osteoarthritis

Summary: this study aims to compare the effects of hyaluronic acid injection and platelet rich plasma injection in terms of pain, physical function and femoral cartilage thickness in short term treatment in patients with knee osteoarthritis.

platelet-rich plasma and hyaluronic acid injections are both popular treatments and commonly used for treatment of knee osteoarthritis. even though there are many studies investigating the effectiveness of these treatments, the results are mostly qualitative. also there are a few studies comparing these two treatment modalities. in this study the investigators aim to compare these modalities both for self-reported data (pain, physical function) and objective measurement data (femoral cartilage thickness via ultrasonography). patients with unilateral osteoarthritis/unilateral complaint will be included in the study. unaffected side will be controls for each group.

Eligibility criteria:
inclusion criteria: * subject is able to consent * subject meets osteoarthritis research society international (oarsi) criteria for knee osteoarthritis * subject has radiographic kellgren-lawrence grade 2-3 osteoarthritis * unilateral osteoarthritis/complaint exclusion criteria: * past or actual knee infection * history of surgery, fracture on knee * collagen tissue disease * systemic inflammatory disease (rheumatoid arthritis, spondyloarthritis etc.) * systemic diseases (diabetes, hematologic diseases, endocrinopathies, renal failure, liver failure) * knee injection in past 6 months * immunodeficiency * pregnant/breastfeeding * malignancy

Keywords: osteoarthritis hyaluronic acid platelet-rich plasma injection
reliability of self-reported concussion history in current rugby union players

Conditions: Concussion, Mild

Summary: perhaps no issue in sports medicine has attracted so much media attention and academic interest in recent years as the potential long-term neurodegenerative sequelae of sports-related concussion on athlete's brain health. rugby has a high incidence of concussion. recent research findings from a cohort of former professional players found that the number of concussions sustained during their professional careers was associated with the rate of diagnosed clinical depression and late-life cognitive impairment. a limitation of these studies is the use of a self-reported history of concussion. the reliability of professional rugby players to recall and self-report concussion history has never been quantified in the literature to date. imperfect recall can generate bias in epidemiologic studies when the proportion of events recalled is associated with the health end points of interest. associations observed may be spurious and due to recall bias if athletes differ in their knowledge and recognition of concussion symptomology in a manner that is associated with the health outcome of interest ie. under/overreporting of concussion. it is difficult to estimate the magnitude of the bias in the absence of any "gold-standard" measure of concussion history. due to these concerns about the quality of self-reported concussion history, the investigators considered that it was important to evaluate the reliability of self-reported concussion history.

the primary aim of this study is to investigate the reliability of self-reported concussion history in current rugby union players objectives: the objectives will be to: investigate player's self-report history of sports-related concussion (number and nature of concussions) in this elite rugby playing group. correlate player self-report with established individual player medical data. repeat this process approximately 6 months later on a sub sample of this cohort, in order to test the reliability of player's reported concussion.

Eligibility criteria:
inclusion criteria: •\> 18 years old * contracted to leinster rugby as a professional rugby player * players who have given informed consent and are willing to participate in the study. * players with a history of sports-related concussion/mild traumatic brain injury. exclusion criteria: • any players with a history of non-sports related concussion/severe traumatic brain injury due to road traffic collisions etc. will be excluded.

Keywords: concussion, rugby, self-report, concussion history, reliability
continuous infusion of terlipressin in septic shock

Conditions: Septic Shock

Summary: the purpose of this study is to determine whether: a)the continuous infusion ultra-low dose of terlipressin (1.3 micrograms/kg/h) is able to stabilize hemodynamic in patients with septic shock, reducing the risk of adverse effects related to the bolus dose.b)the continuous infusion ultra-low dose of terlipressin may be use in lieu of vasopressin.

forty-five septic shock patients requiring vasopressor support to maintain mean arterial pressure between 65 and 75 mmhg despite adequate volume resuscitation were enrolled in the study. patients were randomly allocated to be treated with either a) a continuous terlipressin infusion (1.3 µg•kg-1), b) vasopressin (0.03 u•min-1), or c) titrated norepinephrine (control; each n = 15). in both the terlipressin and vasopressin group, norepinephrine was additionally administered to achieve a mean arterial pressure (map) between 65 and 75 mmhg, if necessary. data from right heart catheterization, thermo-dye dilution catheter, gastric tonometry as well as data from organ function, cytokines concentrations, were obtained at baseline and after 12, 24, 36 and 48 hours.

Eligibility criteria:
inclusion criteria: * clinical diagnosis of septic shock * vasopressor support to maintain mean arterial pressure (map) between 65 and 75 mmhg despite adequate volume resuscitation (pulmonary artery occlusion pressure = 13-18 mmhg and central venous pressure = 8-12 mmhg) exclusion criteria: * pregnancy * present cardiac dysfunction * present or suspected acute mesenteric ischemia

Keywords: sepsis septic shock vasopressin terlipressin
feasibility of delivering a complex behavioral intervention for young adults with diabetes via telehealth

Conditions: Diabetes Mellitus

Summary: feasibility of a complex behavioral intervention for young adults with diabetes: the resilient, empowered, active living-telehealth (real-t) study will evaluate the feasibility of implementing a diabetes management intervention via telehealth in preparation for a large-scale randomized controlled trial (rct) entitled evaluation of a complex behavioral intervention for young adults with diabetes: the resilient, empowered, active living-telehealth (real-t) study.

feasibility of a complex behavioral intervention for young adults with diabetes: the resilient, empowered, active living-telehealth (real-t) feasibility study will evaluate the feasibility of implementing a diabetes management intervention via telehealth in preparation for a large-scale rct. young adulthood is a challenging life stage for many individuals with diabetes; only 17% of yas age 18-25 and 30% age 26-30 attain recommended a1c targets, and fewer than 1/3 perform self-care in accordance with national guidelines. yet, it is a crucial stage for establishing health habits that persist throughout adulthood. to address these issues, our research team developed real diabetes (resilient, empowered, active living with diabetes), a 6-month individually tailored occupational therapy intervention focused on incorporating diabetes self-care into participants' daily habits and routines, and evaluated its efficacy in a pilot randomized controlled trial (n=81). real was shown in intention-to-treat analysis to significantly improve a1c (0.9% reduction; p=0.01) and diabetes-related quality of life (p=0.04). while real was highly promising in terms of its positive impact on health and quality of life, the intervention was delivered through home visits, limiting its potential for broad dissemination. given that our target population experiences significant logistical barriers to clinic attendance (the impetus for our in-home treatment model), we therefore will adapt real to be delivered via telehealth (real-t), a highly promising care delivery model, and evaluate real-t in a large-scale rct. the current feasibility study will evaluate the feasibility of implementing the real-t intervention via telehealth by enrolling 10 participants who are 18-30 years of age, conducting the real-t intervention with all participants over a 3-month period, and assessing the process of implementing the study (feasibility and participant satisfaction).

Eligibility criteria:
inclusion criteria: * diagnosed with either type 1 diabetes or type 2 diabetes for at least 12 months * hemoglobin a1c \>7.5% * resident of los angeles county with no imminent plans to relocate * fluent in english * previous participant in real diabetes study exclusion criteria: * pregnant or planning to become pregnant within the next 4 months * diagnosed with a comorbid cognitive or intellectual disability
alzheimer's plasma extension

Conditions: Preclinical Alzheimer's Disease; Early Preclinical Alzheimer's Disease

Summary: the apex study is a multicenter, observational study designed to capture longitudinal follow-up of plasma biomarkers and cognitive and functional assessments on individuals who screen failed in the ahead study over approximately 4 years. approximately 1000 participants will be enrolled across three groups: * group a: approximately 500 participants who are discordant on screening (plasma positive / positron emission tomography (pet) negative), * group b: approximately 250 participants who are concordant on screening (plasma negative / pet negative), and * group c: approximately 250 participants selected from the individuals who previously screen failed prior to pet for the ahead study with oversampling of racial and ethnic populations underrepresented in alzheimer's disease (ad) clinical trials. primary objectives: * collect longitudinal cognitive and functional assessments and blood-based biomarker data * evaluate, characterize, and compare the longitudinal cognitive and functional data between the three groups of participants * compare longitudinal change across race and ethnicity, sex, and apolipoprotein e (apoe) status exploratory objectives: • collect baseline amyloid pet on participants without prior amyloid pet data (group c)


Eligibility criteria:
inclusion criteria: 1. documentation of the participant's informed consent to study procedures and for the use of protected health information (hipaa authorization, if applicable). informed consent processes and documentation must adhere to state laws/local requirements, including consent provided by the participant's legally authorized representative (lar), responsible next of kin, surrogate consent with assent, etc. 2. previously consented to participate in a3-45 screening. 3. has a3-45 screening plasma biomarker results required for determining eligibility to participate in the a3-45 trial. 4. if an amyloid pet scan was conducted in a3-45, the scan was determined to be below the 20 centiloid cutpoint required for eligibility into the treatment arms of the a3 or a45 trial. 5. as assessed by the site pi, participant is likely to be able to comply with the protocol, including completion of all required procedures for the duration of the study, and has adequate vision, hearing (hearing aid permitted), and literacy in english or spanish sufficient for compliance with required testing procedures. exclusion criteria: 1. current treatment with an fda approved medication for alzheimer's disease, including prior or current treatment with a prohibited medication. 2. enrollment in another investigational study, or intake of investigational drug, within 30 days prior to screening, or five half-lives of the investigational drug, whichever is longer, unless it can be documented that the participant was in the placebo treatment arm. participants enrolled in other observational studies may be permitted with medical monitor review and approval. 3. screen failed from a3-45 due to not meeting basic inclusion criterion (i.e., age requirement; current diagnosis of ad dementia).
effect of combined use of ivermectin and colchicine in covid-19 patients

Conditions: COVID-19

Summary: the aim of this study will be to investigate the efficacy of use of combination of ivermectin and colchicine on severity and outcome of covid 19 infection.


Eligibility criteria:
inclusion criteria: * willing and able to provide written informed consent prior to performing study procedures. * currently hospitalized and requiring medical care for non-sever covid-19. * one or more of the following: (positive pcr test or positive antibodies) or (ct chest consistent with covid19 infection). exclusion criteria: * tocilizumab use. * mechanical ventilation * requirement of oxygen supplementation \>8l/min on admission
snv4818 in participants with advanced solid tumors

Conditions: Advanced Solid Tumors

Summary: this study is testing a new medicine, snv4818, for people with advanced cancers. the researchers want to find out if snv4818 is safe, well-tolerated, and effective in treating solid tumors. they are investigating different doses in order to find the safest and most effective one.


Eligibility criteria:
inclusion criteria: * advanced or metastatic solid tumor with an activating pik3ca mutation. * refractory to or intolerant of available therapies * disease measurable by recist 1.1 criteria, or disease evaluable by clinically relevant tumor biomarkers in blood. * eastern cooperative oncology group (ecog) performance status of 0 or 1 exclusion criteria: * diagnosis of a primary cns malignancy * active brain metastases or carcinomatous meningitis * type 1 diabetes mellitus or uncontrolled type 2 diabetes mellitus * inadequate organ function * clinically significant ecg abnormalities, including qtcf ≥ 470 ms
conversion to sadi-s, rygb or oagb after failed sleeve

Conditions: Weight Loss; Bariatric Surgery Candidate; Comorbidities and Coexisting Conditions; Nutrient Deficiency

Summary: assess what revisional surgery is superior and provides the best weight loss after primary lsg. what is the occurrence of complications and the nutritional laboratory status? and if the resolution and /or improvement of associated medical problems after the weight loss will occur.

laparoscopic sleeve gastrectomy (lsg) gained popularity and has become one of the most performed weight loss procedures worldwide. in the long-term follow-up, the literature states that the incidence of gastroesophageal reflux disease (gerd) accounts for 16%, and weight regains accounting for 70% after lsg. these are the two most common complications which can necessitate further surgical intervention. the hypotheses are that laparoscopic conversion from lsg to single anastomosis duodeno-ileal bypass (sadi-s), roux-en-y gastric bypass (rygb), or one anastomosis gastric bypass (oagb) will provide a new significant weight loss, improvement in obesity-related health problems and provide no nutritional deficiency in all cases. since the three types of procedures have other anatomical presentations, whereby these is not well tested next to each other in a blinded, controlled setting for the patient, this study is designed to discover if the procedures are superior to each other or not and what the best outcome is for the patient. a sample size is calculated and with a medium effect size of 0.5 corresponds to a mean difference in %ebmil between sadi-s, rygb, and oagb of at least 10%. using a power of 0.8 with an alpha of 0.05 resulted in a sample size of 64 patients per group. considering a possible loss of patients to follow-up, an additional 20% increase in sample size was included per group, resulting in a minimum of 78 patients per group. (total of 3 groups together of 234 patients).

Eligibility criteria:
inclusion criteria: * undergone primary laparoscopic sleeve gastrectomy in the past * weight regain * defined as any increase in weight above the nadir as reported by the patient * bmi at the time of revisional surgery was around 45 kg/m2 * weight regain was defined as an increase in bmi after bariatric surgery to exceed 35 * with or without gastroesophageal reflux disease (gerd) grade a and b o patients with grade c or higher gerd, according to the los angeles (la) classification \[7\] will be excluded from the study exclusion criteria: * didn't follow preoperative consultation * cannot give of sign informed consent

Keywords: rygb oagb sadi-s sleeve gastrectomy
infrapatellar versus suprapatellar reamed intramedullary nailing for fractures of the tibia

Conditions: Tibial Fractures; Anterior Knee Pain Syndrome

Summary: this study will investigate the incidence and severity of anterior knee pain comparing two different approaches to tibial nail fixation; infrapatellar versus percutaneous semi-extended suprapatellar incisions. half the patients will be randomized to the gold standard infrapatellar approach with the other half being randomized to treatment with the percutaneous semi-extended suprapatellar approach.

there are a number of ways to approach the tibial canal when using an intramedullary nail for fracture fixation. the gold standard is the infrapatellar approach (below the knee cap). this approach has the patient positioned with the knee flexed at 90 degrees or greater on the operating table. however, there are challenges with this approach, including imaging, placement of supplemental fixation, conversion to open reduction when necessary and malunion with apex anterior angulation for proximal tibial fractures. the positioning of the patient causes tension on the structures and soft tissues around the knee which can hinder the placement of the nail and can cause damage to the soft tissues that can result in significant long-term anterior knee pain for many patients. the semi-extended suprapatellar approach has the patient positioned in approximately 15-20 degrees of flexion, putting less tension on the structures and soft tissues about the knee and enables the surgeon to insert the nail in an optimal position with relative ease.

Eligibility criteria:
inclusion criteria: * all extra-articular tibial fractures * simple distal tibial intra-articular fractures amenable to imn * open and closed fractures * bilateral tibiae * willing and able to consent, follow protocol and attend follow-up visits * able to read and understand english or have interpreter available exclusion criteria: * patients with contralateral femur and/or hip fracture requiring retrograde imn * patients with contralateral knee injuries that would impair their ability to kneel during the follow-up period * associated knee injury * previous symptomatic knee pathology * ipsilateral injuries to the same limb that would interfere with rehab or outcome * neurovascular injuries at the level of the knee requiring surgery * open or closed fractures \> 14 days (times of injury to or) * non unions * pathologic fractures * periprosthetic fractures * spinal injury * non-ambulatory patients * incarceration * limited life expectancy due to significant medical co-morbidities or medical contra-indication to surgery (pregnancy) * likely problems, in the judgment of the investigators, with maintaining follow-up
exercise training in patients with heart failure and permanent atrial fibrillation

Conditions: Heart Failure; Atrial Fibrillation

Summary: the positive effect of physical training in patients with heart failure (hf) has been increasingly established. however, the presence of atrial fibrillation (af), mainly in its permanent form, makes the clinical condition of the patients more compromised.

the positive effect of physical training in patients with heart failure (hf) has been increasingly established. however, the presence of atrial fibrillation (af), mainly in its permanent form, makes the clinical picture of these patients more compromised. the literature has not yet demonstrated studies involving indication of physical exercise therapy when af is associated with hf. thus, the hypothesis is that physical training improves functional capacity, cerebral oxygenation, autonomic aspects, vascular aspects, cardiac function, plasma markers, quality of life and cognitive function of these patients.

Eligibility criteria:
inclusion criteria: * patients with clinically stable nyha class ii to iii heart failure with permanent atrial fibrillation (af); * left ventricular ejection fraction ≤40%; * patients refractory and / or no indication of the treatment of reversal to the rhythm; * patients in optimization specific drug therapy for hf and af. exclusion criteria: * high-frequency ventricular response; * neuromuscular / neuropathy disease; * physical and mental impairment; * chronic obstructive pulmonary disease; * diabetes mellitus; * decompensated arterial hypertension; * autonomic neuropathy; * recent myocardial infarction (\<6 months); * ventricular arrhythmias; * atrial flutter; * renal failure; * use implantable electronic cardiac device or indication for implantation; * pregnancy; * nyha functional class iv; * resting heart rate \<55 bpm; * wolff parkinson white syndrome; * thyroid dysfunction; * unstable angina; * recent history of thromboembolic event; * inability to sign the consent form; * participation in regular physical training program; * use of alcoholic beverages.

Keywords: heart failure, atrial fibrillation and exercise training
school-based program for the prevention of rheumatic heart disease in endemic regions

Conditions: Rheumatic Heart Disease in Children

Summary: the overall objective of the prevent trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (rhd) in regions with an endemic pattern of rhd. we conduct a stepped wedge cluster randomized trial in randomly selected schools in nepal and zambia. the intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about rhd, assessment, intervention, and follow-up of gabhs pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with rhd.


Eligibility criteria:
inclusion criteria: - children aged 5-16 years exclusion criteria: * children / primary caregivers not providing informed consent to participate * children not attending one of the selected schools

Keywords: rheumatic heart disease valvular heart disease prevention streptococcal pharyngitis rheumatic fever