Kornimate/medical-research-clean huggingface dataset:
determination of lymphocyte jam-c expression in patients with psoriasis vulgaris

Conditions: Psoriasis; Psoriasis Vulgaris

Summary: the stepwise process of leukocyte extravasation to inflamed tissues depends on the expression of a variety of cytokines and adhesion molecules. recently much attention has focused on the junctional adhesion molecules (jam). the three members of this adhesion molecule family, namely, jam-a, -b and -c, have been shown to govern the last step of leukocyte extravasation (transmigration) - the process of leukocytes passing between endothelial cells. in addition to transmigration, some members of this family seem to support additional steps in the leukocyte extravasation cascade. the investigators recently showed, that antibody-mediated inhibition of jam-c significantly reduced hapten induced skin inflammation (j invest dermatol;125(5):969). recent unpublished work from our laboratory showed, that jam-c expression of lymphocytes can be up-regulated through specific activators. hence, the investigators hypothesize, that jam-c expression is elevated in patients with psoriasis. as it is currently not know, which factors may influence the expression of jam-c, the investigators intend to analyse jam-c expression on cd3+cd41- cells at several time-points during the treatment of psoriatic patients. expression of jam-c will then be correlated to disease activity (pasi).

the stepwise process of leukocyte extravasation to inflamed tissues depends on the expression of a variety of cytokines and adhesion molecules. recently much attention has focused on the junctional adhesion molecules (jam). the three members of this adhesion molecule family, namely, jam-a, -b and -c, have been shown to govern the last step of leukocyte extravasation (transmigration) - the process of leukocytes passing between endothelial cells. in addition to transmigration, some members of this family seem to support additional steps in the leukocyte extravasation cascade. we recently showed, that antibody-mediated inhibition of jam-c significantly reduced hapten induced skin inflammation (j invest dermatol;125(5):969). recent unpublished work from our laboratory showed, that jam-c expression of lymphocytes can be up-regulated through specific activators. hence, we hypothesize, that jam-c expression is elevated in patients with psoriasis. as it is currently not know, which factors may influence the expression of jam-c, we intend to analyse jam-c expression on cd3+cd41- cells at several time-points during the treatment of psoriatic patients. expression of jam-c will then be correlated to disease activity (pasi). detailed in- and exclusion criteria are outlined below.

Eligibility criteria:
inclusion criteria: * psoriasis vulgaris * pasi \>/= 10 at inclusion exclusion criteria: * psoriasis arthritis * psoriasis pustulosa * psoriasis palmoplantaris * pregnancy * current infectious disease

Keywords: psoriasis jam3 protein, human cell adhesion molecules skin inflammation lymphocytes
efficacy of a mobile phone app for depression and anxiety in college students

Conditions: Depressive Symptoms; Anxiety Symptoms

Summary: the goal of this clinical trial is to evaluate the efficacy of a mobile phone application for the early intervention of depression and anxiety among young university students in chile. the main question it aims to answer is: - can a mobile app reduce depressive and anxious symptomatology in college students? researchers will compare the intervention arm (mobile app users) to the control group (receives psychoeducational material and mental health care resources) to see if the app leads to significant improvements in depressive and anxious symptoms and well-being. participants will: * be randomly assigned to either the intervention or control group. * use the mobile application, which includes psychoeducational materials, cognitive-behavioral therapy modules, and periodic personalized feedback. * complete assessments at baseline, post-intervention, and 3 and 6 months after randomization using online tools such as the phq-9 for depressive symptoms and the gad-7 for anxious symptoms.


Eligibility criteria:
inclusion criteria: * phq-9 and gad-7 score between 5 and 14 points * have a stable internet connection * to provide informed consent exclusion criteria: * high risk of suicide according to c-ssrs * currently undergoing psychological, psychiatric and/or psychopharmacological treatment * bipolar disorder, psychotic disorder or substance use disorder assessed with the respective modules of the mini interview.

Keywords: digital intervention depression anxiety app-based intervention university students well-being college students mobile phone app
treatment of depression with mindfulness, acceptance and commitment

Conditions: Psychotherapy; Depression

Summary: randomized trial to proof the effects and efficacy of a new mindfulness and acceptance based group-treatment for depressive patients

in this study, a randomized trial is conducted in which the participants are allocated to two different care services (mac-cbt® vs. progressive muscle relaxation). participants are patients with depression who have been made aware of the group therapy by their treating physicians or psychotherapists or who have read the advertising in waiting areas or on the investigators homepage. an extensive psychometric survey will be conducted at the start of the study in an interview session with a psychotherapist, who also judges if the participants are able to participate in a therapy group. the mac-cbt® group receives an eight-session group therapy, in which the aspects of mindfulness, acceptance and commitment are taught in detail. the control group will receive an eight-session treatment with progressive muscle relaxation. input and output results are determined using validated survey instruments. in addition, the investigators will check the data for moderating variables (e.g. age, gender, previous treatments...).

Eligibility criteria:
inclusion criteria: * depressive disorder exclusion criteria: * somatic disorder * psychotic disorder * personality disorder

Keywords: acceptance mindfulness commitment group-psychotherapy
the effectiveness of drawing interventions

Conditions: Older Adult

Summary: the study will consist of two stages. the first stage of the study expects to find associations within dependent variables: depression level, resourcefulness, spiritual resourcefulness, and spiritual health in older adults. the second stage estimated that art drawing interventions will be effective for improving depression levels, resourcefulness, spiritual resourcefulness, and spiritual health.

a cross-sectional research design will be used in the first stage, and the second stage of the research will be an intervention and longitudinal study with a randomized control trial design. in the first stage, four instruments will be applied, such as the geriatric depression scale (gds), resourcefulness scale (rs), spiritual resourcefulness scale (sprs), and spiritual screening tool for older adults (sstoa), to measure the levels of depression, resourcefulness, spiritual resourcefulness, and spiritual health of older adults at nursing homes in indonesia. three hundred older adults will be recruited through purposive sampling in the first stage of the study, while 128 participants will be recruited and randomized and assigned to both the experimental and control groups. there will be 64 subjects in each group. the art drawing intervention will be applied and last for 6 weeks in the experimental group. five times of examinations about the related variables will be performed at the first week before intervention implemented (t0); the second measure will be performed 3 weeks after the intervention started (t1); 6 weeks of drawing intervention, the third examine will be tested (t2); and 1 and 2 months after the intervention completed, the participants will be asked to test for the t3 and t4

Eligibility criteria:
inclusion criteria: 1. currently live in nursing home 2. have no physical impairment. 3. have been staying in nursing home for at least 6 months. 4. speak bahasa indonesia exclusion criteria: 1. have been diagnosed with psychiatric illness. 2. have been diagnosed with severe physical disorders such as advanced cancer or motor impairments

Keywords: drawing interventions depression resourcefulness spiritual health older adults
downhill walking in ipf

Conditions: Idiopathic Pulmonary Fibrosis (IPF)

Summary: in this study; will examine the effects of downhill walking (eccentric exercise training) on exercise capacity, quality of life, and blood lactate levels in individuals with ipf. after the initial assessment, patients will be randomized into two groups: downhill walking pr group and standard pr group.

individuals diagnosed with idiopathic pulmonary fibrosis who come to the pulmonary rehabilitation unit of istanbul süreyyapaşa chest diseases and chest surgery education and research hospital will be included in this study. those who meet the inclusion criteria will be randomized into two groups: downhill walking pr group (n=17) and standard pr group (n=17). patients will have exercise sessions twice a week for 8 weeks. patients will be evaluated immediately before the rehabilitation program and the end of 8 weeks exercise programme. in our study, downhill walking training will differ from traditional walking training only in terms of treadmill training protocol. traditional walking training involves walking on a motorized treadmill with a neutral incline, progressing with increases in speed, while downhill walking training will be performed at a constant -10% incline.

Eligibility criteria:
inclusion criteria: * having a diagnosis of ipf according to the clinical diagnostic criteria of the american thoracic society and/or the european respiratory society (ats-ers). * being between the ages of 18 and 75. * being able to walk on a treadmill. * having the ability to cooperate. * no change in current medication in the last month. * not participating in a structured activity program for at least six months. * accepting the purpose and method of this study voluntarily and give informed consent for the study. exclusion criteria: * presence of physical or mental impairment that prevents informed consent or compliance with the protocol. * inability to attend more than 20% of pulmonary rehabilitation sessions. * presence of major cardiovascular disease (coronary artery disease, uncontrolled hypertension, arrhythmias, or heart failure). * presence of existing orthopedic and neuromuscular exercise limitations. * acute exacerbation

Keywords: ipf eccentric exercise training pulmonary rehabilitation
empagliflozin (bi 10773) in type two diabetes (t2d) patients, open label extension

Conditions: Diabetes Mellitus, Type 2

Summary: the objective of the current study is to investigate the safety and efficacy of bi 10773 in 2 different doses compared to metformin or to sitagliptin given for 78 weeks in different modalities of treatment in patients with type 2 diabetes mellitus.


Eligibility criteria:
inclusion criteria: * patients completing one of double blind phase ii trials 1245.9 or 1245.10 * informed consent exclusion criteria: * patients meeting withdrawal criteria of preceding trial * significant hepatic impairment * significant renal impairment with creatinine clearance \< 50 ml/min * contraindication to metformin for all patients treated with metformin * premenopausal women that are nursing or pregnant or not practicing acceptable methods of birth control * drug or alcohol abuse
efficacy and safety of xav-19 for the treatment of moderate-to-severe covid-19

Conditions: COVID-19

Summary: the purpose of this study is to evaluate the efficacy and safety of xav-19 drug in patients with moderate-to-severe covid-19.


Eligibility criteria:
inclusion criteria: i1) male or female patient aged 18 years or over, weighing \>50 kg and \<120 kg, at the time of signing the informed consent, i2) patient presenting in a specialized or an emergency unit i3) patient presenting signs of pneumonia evidenced by at least 1 of the following: auscultation, chest x-ray, ct scan or presenting covid-19 related symptoms having started less than 10 days prior to screening visit, including at least 2 of the following: fever, cough, sore throat or nasal discharge, dyspnea (shortness of breath), thoracic pain, headache or fatigue, myalgia, anosmia, dysgeusia, diarrhea, nausea i4) patient with spo2 \> 90% (at ambient air) i5) patient with a first positive sars-cov-2 test (rt-pcr, rt-qpcr or antigen test) in the last 10 days or at screening i6) women of childbearing potential (wocbp) must have a negative urine pregnancy test at screening and use a highly effective birth control until 90 days after the administration of study drug i7) non-vasectomized male patients having a female partner of childbearing potential must agree to use a highly effective method of contraception until 90 days after the administration of study drug, i8) patient capable of giving signed informed consent. exclusion criteria: e1) patient with a positive sars cov-2 test (rt-pcr, rt-qpcr or antigen test) of more than 10 days before the screening visit e2) patient with multiorgan failure e3) patient requiring immediate intensive care unit (icu) hospitalization e4) patient participating in another clinical trial with an investigative agent e5) pregnancy or breastfeeding

Keywords: covid-19 sars-cov-2 polyclonal igg
reproducibility of fnirs parameters during walking

Conditions: Stroke

Summary: brain activation can be studied using the functional near infrared spectroscopy (fnirs). it was shown that cpf activation during walking and during dual task could be different in stroke patients and in healthy subjects. to date, fnirs reliability is not completely established during walking and during dual task. therefore, this study will examine the reproducibility of fnirs parameters during simple walking and during dual task in healthy subjects and in stroke patients.

a fnirs system will be used to measure the cpf activation. the subjects will walk at their preferred speed on 10 m 3 times and while doing a cognitive task (dual task) 3 times also (in a random order). the same test will be repeated five minutes later. the fnirs system will be retired and the same test will be repeated 10 min later.

Eligibility criteria:
inclusion criteria: * acute stroke group, subacute stroke group, and control group: * age 50 to 80 years * affiliated with a social security plan * able to walk 20 meters unassisted * acute stroke and subacute stroke group: * stroke onset less than 14 days (for the acute stroke group) or between 14 days and 6 months (for the subacute stroke group) * stroke located in the left or right middle cerebral artery. exclusion criteria: * acute stroke group, subacute stroke group, and control group: * person under guardianship or curatorship * refusal to sign informed consent * known rheumatologic or cardiologic history * medication that alters the vigilance and may affect walking (high dose psychotropic drugs, antispastic drugs). * acute stroke group and subacute stroke group: * history of symptomatic stroke * previous neurological disease limiting gait, aphasia or impaired cognitive function (mild cognitive dementia, alzheimer's or parkinson's disease) * ambulatory functional category \< 3 * control group: neurological medical history

Keywords: fnirs reproductibility stroke gait
accu-chek combo in young patients

Conditions: Type 1 Diabetes

Summary: this is an open, prospective, descriptive study aiming to evaluate the change in treatment satisfaction of primary care givers of young children who use the accu-chek combo system. patients will routinely be scheduled and start their therapy with the accu-chek combo system on visit 1. twelve weeks later the final acquisition of data will occur. diabetes treatment satisfaction questionnaires (dtsq) will be completed at baseline and after 12 weeks, a distinct acceptance questionnaires will be completed at final visit. in addition, diabetes related therapeutic information will be collected and data about the use of the device components will be downloaded from the accu-chek combo system


Eligibility criteria:
inclusion criteria: * diabetes mellitus type 1 * continuous subcutaneous insulin infusion(csii)therapy(for at least 6 months) * age below 6 years * planned and scheduled change to a accu-chek combo system within the next 3 weeks at least * signing on an inform consent form exclusion criteria: * patient has been diagnosed with progressive/serious diseases that in judgment of the physician preclude successful completion of the observational period * primary care giver not skilled enough to comment in a qualitative way

Keywords: insulin pump therapy type 1 diabetes treatment satisfaction
erector spinae plane block for cervical spine surgery

Conditions: Spine Fusion; Spine Disease; Spinal Disease

Summary: the study aims to assess the interfacial plane blocks' effect on pain level, course of postoperative rehabilitation, and anti-inflammatory analgesic effect.

this study evaluates the analgesic efficacy in adults of bilevel, bilateral erector spinae plane (esp) blocks after posterior cervical spinal fusion surgery by assessing postoperative pain scores and opiate requirements as the primary outcome measures. we aim to investigate how esp blocks, performed under ultrasound guidance at the two vertebral levels, contribute to postoperative pain control. this will be determined by measuring numerical rating pain scores repeatedly following surgery and opiate consumption until the patient is discharged from the hospital. these primary outcome measures will be compared between a treatment group of participants receiving esp blocks and a control group receiving a sham block. our primary hypothesis is that esp blocks significantly reduce postoperative pain and opiate requirements.

Eligibility criteria:
inclusion criteria: * patients undergoing primary posterior cervical decompression and stabilization with instrumentation involving multi-levels in the cervical region, * aged \>18 years and \<100 years * asa physical status 1, 2 or 3. exclusion criteria: * refuse to participate, * history of opioid abuse, * infection of the puncture site, * aged \ 100 years * asa 4 and 5
angiomammography and neoadjuvant chemotherapy

Conditions: Breast Neoplasms

Summary: the best prognostic factor following neoadjuvant chemotherapy is the pathological complete response (pcr). pcr is defined as the absence of invading cells in the breast and lymph nodes following neoadjuvant chemotherapy treatment. since patients with pcr have a better prognosis than those without pcr, some studies have evaluated different methods to predict pcr early in treatment. thus, patients who do not respond optimally to treatment could be identified early and changed treatment in order to maximize the chances of pcr and avoid the morbidity of poorly effective treatments. to do this, several modalities have been proposed, including mri, mammography, ultrasound, positron emission tomography, elastography, and serial biopsies, but these techniques have shown predictive and sometimes expensive. nevertheless, assessment of tumor response after cycle 2 has been suggested to be appropriate for the prediction of pcr. the main objective of this study is to compare the performance of two diagnostic modalities, namely cesm and mri, in the evaluation of the response of a malignant breast tumor to neoadjuvant chemotherapy and the prediction of pcr. the radiological response will also be compared to the clinical response.


Eligibility criteria:
inclusion criteria: * female aged 18 and over * histologically proven breast cancer by large gauge needle * no evidence of distant metastasis * neoadjuvant chemotherapy with or without concomitant targeted therapy * breast tumor initially measurable by clinical examination exclusion criteria: * refusal to perform the biopsy or surgery * pregnant or possibly pregnant woman * usual contraindication to contrast product * significant kidney failure * allergy to contrast medium * frank hyperthyroidism * usual contraindications to mri
malditof versus routine clinical microbiology for identifying pathogens; a randomized diagnostic trial

Conditions: Bacterial Infections; Fungal Infections

Summary: maldi-tof ms is capable of directly identifying bacteria and fungi in positive blood cultures, which may be beneficial to patient management. therefore, maldi-tof ms is an important new technology that is becoming routine in developed countries. it is currently unknown whether malditof ms improves diagnostics, costs and patient outcomes in developing countries. this study will assess the clinical impact of a malditof ms system (maldi biotyper, bruker, germany) in the resource constrained setting of vietnam and at what cost.

when an eligible specimen from a patient shows pathogen growth, the pathogen identification will be randomized to either malditof or routine diagnostics ('diagnostic pipelines'). randomization to malditof or routine diagnostics will be 1:1 with stratification by hospital and specimen type (blood vs. other). isolates grown from all eligible specimens of the same patient will be assigned to the same diagnostic pipeline as the first randomized specimen of that patient. allocation to diagnostic arm will be assigned by a web based randomization program. when a pathogen is isolated from a positive eligible specimen, the laboratory technician will log onto the secure randomization program and enter the patient and specimen code. the random diagnostic pipeline allocation will then be generated, informed to the laboratory technician and logged in the study database. in the case of multiple specimens with pathogen growth for a single patient, the unique patient code will trigger the randomization program to generate the same diagnostic arm allocation as the previous sample(s).

Eligibility criteria:
inclusion criteria: pathogen isolates from the following specimens: blood or diagnostic aspirates from normally sterile sites (including cerebrospinal fluid (csf), deep abscesses, joint fluid, peritoneal fluid, and pleural fluid, deep tissue biopsies). exclusion criteria: * specimens negative for all pathogens * specimens from sputum, respiratory or non-surgical wound swabs, nails, mucosal or skin biopsies, urine, fluid from drains, skin swabs and any others not listed in the inclusion criteria.

Keywords: malditof malditof ms matrix-assisted laser desorption ionization-time identifying pathogens randomized diagnostic trial
adrenaline during resuscitation from pulseless electrical activity

Conditions: Heart Arrest

Summary: this is a prospective observational study at st. olavs hospital in norway. data are gathered from defibrillators that have been in use during resuscitation from cardiac arrest. aim is to investigate the changes in electrocardiograms (ecg) during resuscitation from pulseless electrical activity (pea), which is a type of cardiac arrest. ecg changes may be useful as a prognostic marker during resuscitation from pea. in addition the researchers will describe the effect of adrenaline and chest compressions on clinical state transitions during resuscitation from pulseless electrical activity. clinical state transitions are changes between different types of cardiac arrest. this study is expected to increase our understanding of the dynamics during treatment of cardiac arrest.


Eligibility criteria:
inclusion criteria: cardiac arrest among hospitalized patients presenting with pea as the primary rhythm.

Keywords: epinephrine pulseless electrical activity